locus-tag	class	description
MS6_0004	COG1126	abc transporter atp-binding protein
MS6_0005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MS6_0006	COG0594	ribonuclease P activity
MS6_0007	COG0706	membrane insertase activity
MS6_0008	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MS6_0009	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MS6_0010	COG0445	tRNA wobble uridine modification
MS6_0011	COG0357	Ribosomal RNA small subunit methyltransferase G
MS6_0012	COG1192	Involved in chromosome partitioning
MS6_0013	COG1475	DNA binding
MS6_0014	COG3312	ion transport
MS6_0015	COG0356	it plays a direct role in the translocation of protons across the membrane
MS6_0017	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MS6_0018	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MS6_0019	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MS6_0020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MS6_0021	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MS6_0022	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MS6_0023	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MS6_0024	COG2814	Major facilitator Superfamily
MS6_0025	COG0583	DNA-binding transcription factor activity
MS6_0026	COG0183	Belongs to the thiolase family
MS6_0027	COG1250	3-hydroxyacyl-CoA dehydrogenase
MS6_0027	COG1024	Enoyl-CoA hydratase
MS6_0028	COG1739	Uncharacterized protein family UPF0029
MS6_0029	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MS6_0030	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MS6_0032	COG0583	DNA-binding transcription factor activity
MS6_0033	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MS6_0034	COG2960	long-chain fatty acid transporting porin activity
MS6_0035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_0036	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_0037	COG1309	transcriptional regulator
MS6_0042	COG0747	negative chemotaxis
MS6_0044	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MS6_0046	COG2131	deaminase
MS6_0055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_0056	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MS6_0058	COG0210	DNA helicase
MS6_0059	COG1280	lysine exporter protein (LysE YggA)
MS6_0062	COG2962	Rard protein
MS6_0064	COG0514	ATP-dependent DNA helicase (RecQ)
MS6_0067	COG1132	(ABC) transporter
MS6_0068	COG4774	siderophore transport
MS6_0069	COG1120	ATPase activity
MS6_0073	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MS6_0074	COG1263	PTS System
MS6_0074	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_0076	COG1561	YicC-like family, N-terminal region
MS6_0077	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MS6_0078	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MS6_0079	COG1560	Kdo2-lipid A biosynthetic process
MS6_0080	COG1560	Kdo2-lipid A biosynthetic process
MS6_0081	COG1309	transcriptional regulator
MS6_0083	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MS6_0087	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MS6_0088	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MS6_0090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MS6_0091	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MS6_0092	COG0859	PFAM glycosyl transferase family 9
MS6_0093	COG0463	Glycosyl transferase, family 2
MS6_0094	COG0859	PFAM glycosyl transferase family 9
MS6_0095	COG3642	lipopolysaccharide core region biosynthetic process
MS6_0101	COG1519	Transferase
MS6_0108	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MS6_0109	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MS6_0109	COG0662	Cupin 2, conserved barrel domain protein
MS6_0110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MS6_0111	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MS6_0117	COG0318	PFAM AMP-dependent synthetase and ligase
MS6_0118	COG1454	alcohol dehydrogenase
MS6_0118	COG1012	belongs to the aldehyde dehydrogenase family
MS6_0120	COG5433	transposase activity
MS6_0121	COG5433	transposase activity
MS6_0126	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MS6_0128	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MS6_0129	COG0668	transmembrane transport
MS6_0130	COG1573	uracil-dna glycosylase
MS6_0132	COG3068	Protein conserved in bacteria
MS6_0134	COG1940	carbohydrate kinase activity
MS6_0135	COG1253	flavin adenine dinucleotide binding
MS6_0136	COG0776	regulation of translation
MS6_0138	COG0151	Belongs to the GarS family
MS6_0139	COG0138	bifunctional purine biosynthesis protein purh
MS6_0141	COG0789	Transcriptional regulator
MS6_0142	COG3710	Transcriptional regulator
MS6_0144	COG0531	amino acid
MS6_0145	COG1982	Orn Lys Arg decarboxylase major
MS6_0146	COG0840	transmembrane signaling receptor activity
MS6_0149	COG0800	Aldolase
MS6_0151	COG3265	gluconokinase activity
MS6_0152	COG0129	dihydroxy-acid dehydratase activity
MS6_0153	COG1609	Transcriptional regulator
MS6_0154	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MS6_0155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MS6_0157	COG0439	Biotin carboxylase
MS6_0158	COG0511	ligase activity, forming carbon-carbon bonds
MS6_0159	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MS6_0160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MS6_0163	COG2814	Major facilitator Superfamily
MS6_0164	COG0784	Response regulator, receiver
MS6_0164	COG2205	protein histidine kinase activity
MS6_0165	COG0248	Ppx GppA phosphatase
MS6_0166	COG0513	Belongs to the DEAD box helicase family
MS6_0167	COG3118	belongs to the thioredoxin family
MS6_0168	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MS6_0170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MS6_0173	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MS6_0175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MS6_0177	COG1072	(Pantothenic acid kinase))
MS6_0178	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MS6_0179	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MS6_0180	COG0250	Participates in transcription elongation, termination and antitermination
MS6_0181	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MS6_0182	COG0081	regulation of translation
MS6_0183	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MS6_0184	COG0222	ribosome binding
MS6_0185	COG0085	RNA polymerase activity
MS6_0186	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MS6_0187	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MS6_0188	COG2816	NAD+ diphosphatase activity
MS6_0189	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MS6_0192	COG4942	peptidase
MS6_0193	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MS6_0195	COG0471	metal ion transport
MS6_0196	COG0688	phosphatidylethanolamine metabolic process
MS6_0197	COG1162	GTPase activity
MS6_0198	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MS6_0199	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MS6_0200	COG0802	atpase or kinase
MS6_0202	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MS6_0203	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MS6_0204	COG1923	regulation of RNA biosynthetic process
MS6_0205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MS6_0206	COG0330	HflC and HflK could
MS6_0207	COG0330	HflC and HflK could
MS6_0208	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MS6_0209	COG2900	Belongs to the SlyX family
MS6_0211	COG0545	Peptidyl-prolyl cis-trans isomerase
MS6_0212	COG2964	Protein conserved in bacteria
MS6_0213	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MS6_0214	COG2923	Belongs to the DsrF TusC family
MS6_0216	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MS6_0217	COG0049	tRNA binding
MS6_0218	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MS6_0219	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MS6_0220	COG2906	2 iron, 2 sulfur cluster binding
MS6_0222	COG0360	Binds together with S18 to 16S ribosomal RNA
MS6_0223	COG2965	DNA replication, synthesis of RNA primer
MS6_0224	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MS6_0225	COG0359	binds to the 23S rRNA
MS6_0227	COG0305	Participates in initiation and elongation during chromosome replication
MS6_0228	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MS6_0229	COG0432	Pfam Uncharacterised protein family UPF0047
MS6_0230	COG0166	Belongs to the GPI family
MS6_0233	COG0735	belongs to the Fur family
MS6_0234	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MS6_0240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MS6_0241	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MS6_0242	COG0175	sulfate reduction
MS6_0244	COG0646	methionine synthase
MS6_0244	COG1410	methionine synthase
MS6_0245	COG0527	aspartate kinase activity
MS6_0246	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MS6_0248	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MS6_0251	COG0629	single-stranded DNA binding
MS6_0252	COG2200	EAL domain
MS6_0252	COG2199	diguanylate cyclase activity
MS6_0257	COG3409	Peptidoglycan-binding domain 1 protein
MS6_0257	COG3267	Type II secretory pathway component ExeA
MS6_0259	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_0260	COG1459	type II secretion system
MS6_0269	COG1077	Cell shape determining protein MreB Mrl
MS6_0270	COG1792	Involved in formation and maintenance of cell shape
MS6_0271	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MS6_0272	COG0424	maF-like protein
MS6_0273	COG1530	ribonuclease E activity
MS6_0274	COG3164	Protein of unknown function
MS6_0275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MS6_0276	COG0312	modulator of DNA gyrase
MS6_0277	COG2235	arginine
MS6_0281	COG0589	response to stress
MS6_0284	COG1438	arginine binding
MS6_0285	COG0039	L-malate dehydrogenase activity
MS6_0286	COG0531	amino acid
MS6_0287	COG0142	geranyltranstransferase activity
MS6_0288	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MS6_0289	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MS6_0290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MS6_0291	COG2966	Psort location CytoplasmicMembrane, score
MS6_0292	COG3610	response to peptide
MS6_0294	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MS6_0295	COG2967	ApaG domain
MS6_0296	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MS6_0297	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MS6_0298	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MS6_0299	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MS6_0300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MS6_0302	COG0741	lytic transglycosylase activity
MS6_0303	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MS6_0304	COG1194	a g-specific adenine glycosylase
MS6_0305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MS6_0306	COG2066	Belongs to the glutaminase family
MS6_0307	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MS6_0308	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MS6_0311	COG0762	integral membrane protein
MS6_0312	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MS6_0313	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MS6_0317	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MS6_0318	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MS6_0319	COG1678	Uncharacterized ACR, COG1678
MS6_0320	COG0189	ligase activity
MS6_0321	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MS6_0322	COG2356	endonuclease I
MS6_0323	COG3091	SprT-like family
MS6_0324	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MS6_0326	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MS6_0327	COG0583	DNA-binding transcription factor activity
MS6_0328	COG4771	TonB-dependent receptor
MS6_0329	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MS6_0330	COG0126	phosphoglycerate kinase activity
MS6_0331	COG0191	fructose-bisphosphate aldolase activity
MS6_0332	COG0668	transmembrane transport
MS6_0333	COG1279	arginine transmembrane transporter activity
MS6_0334	COG0583	DNA-binding transcription factor activity
MS6_0337	COG0469	pyruvate kinase activity
MS6_0338	COG1349	DNA-binding transcription factor activity
MS6_0339	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MS6_0340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MS6_0342	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MS6_0343	COG0358	DNA primase activity
MS6_0344	COG1610	YqeY-like protein
MS6_0345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MS6_0347	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MS6_0349	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MS6_0350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MS6_0351	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MS6_0352	COG1968	undecaprenyl-diphosphatase activity
MS6_0353	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MS6_0354	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MS6_0355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MS6_0356	COG0585	pseudouridine synthase activity
MS6_0357	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MS6_0358	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MS6_0359	COG4942	peptidase
MS6_0359	COG1388	LysM domain
MS6_0360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MS6_0361	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MS6_0365	COG4208	sulfate ABC transporter
MS6_0366	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MS6_0368	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MS6_0369	COG2137	regulation of response to DNA damage stimulus
MS6_0370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MS6_0372	COG0527	aspartate kinase activity
MS6_0373	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MS6_0374	COG3630	sodium ion export across plasma membrane
MS6_0375	COG5016	pyruvate
MS6_0375	COG0511	ligase activity, forming carbon-carbon bonds
MS6_0376	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MS6_0378	COG1238	metal cluster binding
MS6_0379	COG0612	Peptidase, M16
MS6_0380	COG2918	glutathione biosynthetic process
MS6_0381	COG1854	S-ribosylhomocysteine lyase activity
MS6_0382	COG4536	flavin adenine dinucleotide binding
MS6_0383	COG4137	Cytochrome C assembly protein
MS6_0384	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MS6_0385	COG0228	four-way junction DNA binding
MS6_0386	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MS6_0387	COG0336	Belongs to the RNA methyltransferase TrmD family
MS6_0388	COG0335	large ribosomal subunit rRNA binding
MS6_0389	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MS6_0390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MS6_0392	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MS6_0393	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MS6_0394	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MS6_0395	COG0723	plastoquinol--plastocyanin reductase activity
MS6_0396	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MS6_0397	COG2857	Cytochrome c1
MS6_0398	COG0625	glutathione transferase activity
MS6_0399	COG2969	positive regulation of protein catabolic process
MS6_0400	COG2823	Periplasmic or secreted lipoprotein
MS6_0401	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MS6_0402	COG0792	nuclease activity
MS6_0403	COG3107	peptidoglycan biosynthetic process
MS6_0404	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MS6_0407	COG0288	reversible hydration of carbon dioxide
MS6_0408	COG0659	secondary active sulfate transmembrane transporter activity
MS6_0409	COG1131	(ABC) transporter
MS6_0410	COG0842	Transport permease protein
MS6_0411	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MS6_0412	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MS6_0413	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MS6_0415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MS6_0416	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MS6_0417	COG1489	DNA binding
MS6_0419	COG1643	Atp-dependent helicase
MS6_0420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MS6_0421	COG1752	Esterase of the alpha-beta hydrolase superfamily
MS6_0422	COG1049	propionate catabolic process, 2-methylcitrate cycle
MS6_0423	COG3112	Uncharacterised protein family (UPF0231)
MS6_0424	COG0347	Belongs to the P(II) protein family
MS6_0425	COG0004	ammonium transporteR
MS6_0426	COG1840	ABC-type Fe3 transport system, periplasmic component
MS6_0428	COG3842	ATPase activity
MS6_0432	COG2971	BadF BadG BcrA BcrD
MS6_0434	COG4608	Belongs to the ABC transporter superfamily
MS6_0435	COG0444	Belongs to the ABC transporter superfamily
MS6_0436	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MS6_0437	COG0601	transmembrane transport
MS6_0438	COG0747	negative chemotaxis
MS6_0440	COG2813	Specifically methylates the guanine in position
MS6_0441	COG0628	permease
MS6_0443	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MS6_0445	COG0316	Belongs to the HesB IscA family
MS6_0448	COG0739	heme binding
MS6_0449	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MS6_0450	COG2027	D-alanyl-D-alanine carboxypeptidase
MS6_0451	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MS6_0452	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MS6_0453	COG1534	Rna-binding protein
MS6_0454	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MS6_0455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MS6_0456	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MS6_0457	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MS6_0458	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MS6_0459	COG0779	Required for maturation of 30S ribosomal subunits
MS6_0460	COG0195	Participates in both transcription termination and antitermination
MS6_0461	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MS6_0462	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MS6_0463	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MS6_0464	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MS6_0465	COG1185	polyribonucleotide nucleotidyltransferase activity
MS6_0466	COG4785	May be involved in cell division
MS6_0474	COG3153	acetyltransferase
MS6_0478	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MS6_0479	COG0513	Belongs to the DEAD box helicase family
MS6_0480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MS6_0482	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MS6_0483	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MS6_0484	COG2204	response regulator
MS6_0488	COG0667	Aldo Keto reductase
MS6_0489	COG3066	DNA modification
MS6_0492	COG0494	nUDIX hydrolase
MS6_0493	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
MS6_0494	COG0730	response to heat
MS6_0495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MS6_0496	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MS6_0497	COG1283	sodium-dependent phosphate transmembrane transporter activity
MS6_0498	COG0583	DNA-binding transcription factor activity
MS6_0499	COG0640	Transcriptional regulator
MS6_0500	COG0268	Binds directly to 16S ribosomal RNA
MS6_0501	COG0728	peptidoglycan biosynthetic process
MS6_0502	COG0196	riboflavin kinase activity
MS6_0503	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MS6_0504	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MS6_0505	COG1047	Peptidyl-prolyl cis-trans
MS6_0506	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MS6_0507	COG1966	Carbon starvation protein
MS6_0510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MS6_0511	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MS6_0512	COG1472	Belongs to the glycosyl hydrolase 3 family
MS6_0513	COG3279	Response regulator of the LytR AlgR family
MS6_0514	COG3275	phosphorelay sensor kinase activity
MS6_0515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MS6_0516	COG0287	Prephenate dehydrogenase
MS6_0516	COG1605	Chorismate mutase
MS6_0518	COG0488	(ABC) transporter
MS6_0520	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
MS6_0521	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MS6_0522	COG5001	Diguanylate cyclase
MS6_0523	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MS6_0524	COG0077	Prephenate dehydratase
MS6_0524	COG1605	Chorismate mutase
MS6_0525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MS6_0527	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MS6_0528	COG0564	pseudouridine synthase activity
MS6_0530	COG0542	response to heat
MS6_0533	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MS6_0535	COG2974	May be involved in recombination
MS6_0536	COG0745	RESPONSE REGULATOR receiver
MS6_0537	COG5002	protein histidine kinase activity
MS6_0539	COG0248	Ppx GppA phosphatase
MS6_0540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MS6_0542	COG0581	inorganic phosphate transmembrane transporter activity
MS6_0543	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MS6_0546	COG3142	Participates in the control of copper homeostasis
MS6_0547	COG0450	alkyl hydroperoxide reductase
MS6_0548	COG0583	DNA-binding transcription factor activity
MS6_0549	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MS6_0551	COG0517	IMP dehydrogenase activity
MS6_0552	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MS6_0553	COG0343	queuine tRNA-ribosyltransferase activity
MS6_0554	COG1862	Preprotein translocase
MS6_0555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MS6_0556	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MS6_0557	COG0483	inositol monophosphate 1-phosphatase activity
MS6_0559	COG1959	2 iron, 2 sulfur cluster binding
MS6_0560	COG1104	cysteine desulfurase activity
MS6_0561	COG0822	iron-sulfur transferase activity
MS6_0562	COG0316	Belongs to the HesB IscA family
MS6_0563	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MS6_0564	COG0443	Heat shock 70 kDa protein
MS6_0565	COG0633	Ferredoxin
MS6_0566	COG2975	iron-sulfur cluster assembly
MS6_0567	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MS6_0568	COG0105	UTP biosynthetic process
MS6_0569	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MS6_0571	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MS6_0572	COG0124	histidyl-tRNA synthetase
MS6_0573	COG2976	Protein conserved in bacteria
MS6_0574	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MS6_0575	COG1160	GTP binding
MS6_0578	COG1570	exodeoxyribonuclease VII activity
MS6_0579	COG0517	IMP dehydrogenase activity
MS6_0579	COG0516	GMP reductase activity
MS6_0580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MS6_0580	COG0519	Catalyzes the synthesis of GMP from XMP
MS6_0582	COG1584	GPR1 FUN34 yaaH family protein
MS6_0583	COG3433	isochorismatase activity
MS6_0583	COG1535	isochorismatase
MS6_0584	COG1021	2,3-dihydroxybenzoate-AMP ligase
MS6_0585	COG1169	isochorismate synthase
MS6_0586	COG1028	Short-chain dehydrogenase reductase Sdr
MS6_0588	COG4592	Periplasmic binding protein
MS6_0589	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MS6_0590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MS6_0591	COG1120	ATPase activity
MS6_0593	COG0583	DNA-binding transcription factor activity
MS6_0594	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MS6_0595	COG1115	amino acid carrier protein
MS6_0596	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MS6_0597	COG0583	DNA-binding transcription factor activity
MS6_0600	COG4565	transcriptional regulatory protein
MS6_0602	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MS6_0603	COG0511	ligase activity, forming carbon-carbon bonds
MS6_0603	COG5016	pyruvate
MS6_0604	COG3630	sodium ion export across plasma membrane
MS6_0606	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MS6_0607	COG3052	prosthetic group binding
MS6_0608	COG2301	Belongs to the HpcH HpaI aldolase family
MS6_0609	COG3051	citrate lyase alpha subunit
MS6_0610	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
MS6_0611	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
MS6_0613	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MS6_0614	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MS6_0615	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MS6_0626	COG1012	belongs to the aldehyde dehydrogenase family
MS6_0630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MS6_0631	COG0840	transmembrane signaling receptor activity
MS6_0632	COG3710	Transcriptional regulator
MS6_0634	COG2165	general secretion pathway protein
MS6_0637	COG4796	Type ii and iii secretion system protein
MS6_0641	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_0642	COG1459	type II secretion system
MS6_0644	COG2207	Transcriptional regulator
MS6_0645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MS6_0648	COG0739	heme binding
MS6_0650	COG3064	Membrane
MS6_0652	COG0582	viral genome integration into host DNA
MS6_0653	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MS6_0654	COG2867	negative regulation of translational initiation
MS6_0655	COG2914	Belongs to the UPF0125 (RnfH) family
MS6_0656	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MS6_0657	COG0497	DNA recombination
MS6_0658	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MS6_0659	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MS6_0661	COG0443	Heat shock 70 kDa protein
MS6_0662	COG0484	heat shock protein binding
MS6_0668	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MS6_0669	COG0590	tRNA wobble adenosine to inosine editing
MS6_0671	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MS6_0674	COG0047	phosphoribosylformylglycinamidine synthase activity
MS6_0674	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MS6_0678	COG0442	prolyl-tRNA aminoacylation
MS6_0679	COG1720	tRNA m6t6A37 methyltransferase activity
MS6_0680	COG0254	rRNA binding
MS6_0681	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MS6_0682	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MS6_0683	COG1671	Belongs to the UPF0178 family
MS6_0685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_0688	COG3098	single-species biofilm formation
MS6_0689	COG0564	pseudouridine synthase activity
MS6_0690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MS6_0691	COG0142	geranyltranstransferase activity
MS6_0692	COG1722	exodeoxyribonuclease VII activity
MS6_0693	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MS6_0695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MS6_0695	COG0301	tRNA thio-modification
MS6_0696	COG0583	DNA-binding transcription factor activity
MS6_0697	COG2363	Small membrane protein
MS6_0698	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MS6_0699	COG1611	Belongs to the LOG family
MS6_0700	COG3706	GGDEF domain
MS6_0702	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MS6_0702	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MS6_0704	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
MS6_0705	COG1464	Belongs to the NlpA lipoprotein family
MS6_0706	COG2011	ABC-type metal ion transport system permease component
MS6_0707	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MS6_0708	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MS6_0709	COG1609	Transcriptional regulator
MS6_0710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_0710	COG1263	PTS System
MS6_0711	COG0366	Alpha amylase catalytic
MS6_0713	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_0714	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MS6_0715	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MS6_0716	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MS6_0717	COG0110	maltose O-acetyltransferase activity
MS6_0721	COG1045	serine acetyltransferase
MS6_0723	COG0438	transferase activity, transferring glycosyl groups
MS6_0725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MS6_0731	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MS6_0733	COG1596	polysaccharide export
MS6_0738	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MS6_0740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MS6_0741	COG0321	lipoyl(octanoyl) transferase activity
MS6_0742	COG2921	Belongs to the UPF0250 family
MS6_0743	COG1686	Belongs to the peptidase S11 family
MS6_0744	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MS6_0745	COG0772	Belongs to the SEDS family
MS6_0746	COG0768	penicillin binding
MS6_0747	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MS6_0748	COG0799	negative regulation of ribosome biogenesis
MS6_0749	COG1466	dna polymerase III delta subunit
MS6_0750	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MS6_0751	COG0495	leucyl-tRNA aminoacylation
MS6_0752	COG2888	peptidyl-tyrosine sulfation
MS6_0753	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MS6_0754	COG4535	Mg2 and Co2 transporter CorC
MS6_0755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MS6_0756	COG1702	phosphate starvation-inducible protein PhoH
MS6_0757	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MS6_0758	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_0759	COG2190	(PTS) system
MS6_0761	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_0762	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MS6_0763	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MS6_0764	COG3115	cell septum assembly
MS6_0765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MS6_0768	COG0789	Transcriptional regulator
MS6_0769	COG1585	Membrane protein implicated in regulation of membrane protease activity
MS6_0770	COG0330	HflC and HflK could
MS6_0771	COG3118	belongs to the thioredoxin family
MS6_0773	COG0300	oxidoreductase activity
MS6_0774	COG1090	epimerase
MS6_0775	COG0622	Phosphoesterase
MS6_0778	COG3710	Transcriptional regulator
MS6_0779	COG0326	Molecular chaperone. Has ATPase activity
MS6_0780	COG0563	adenylate kinase activity
MS6_0781	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MS6_0785	COG0367	asparagine synthase
MS6_0786	COG4651	solute:proton antiporter activity
MS6_0786	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MS6_0787	COG1846	Transcriptional regulator
MS6_0787	COG1940	carbohydrate kinase activity
MS6_0788	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MS6_0789	COG1263	PTS System
MS6_0789	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_0789	COG2190	(PTS) system
MS6_0790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MS6_0793	COG0101	tRNA pseudouridine synthase activity
MS6_0794	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MS6_0795	COG0285	dihydrofolate synthase activity
MS6_0796	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MS6_0797	COG1286	toxin biosynthetic process
MS6_0798	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MS6_0799	COG2056	Na+-H+ antiporter family
MS6_0800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MS6_0804	COG0346	lactoylglutathione lyase activity
MS6_0805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MS6_0806	COG4660	Part of a membrane complex involved in electron transport
MS6_0807	COG4659	FMN binding
MS6_0808	COG4658	electron transport chain
MS6_0809	COG4656	Part of a membrane complex involved in electron transport
MS6_0810	COG2878	Part of a membrane complex involved in electron transport
MS6_0811	COG4657	Part of a membrane complex involved in electron transport
MS6_0813	COG0556	nucleotide-excision repair
MS6_0814	COG2204	response regulator
MS6_0815	COG2198	Histidine kinase
MS6_0816	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MS6_0817	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MS6_0818	COG0521	Mo-molybdopterin cofactor biosynthetic process
MS6_0819	COG0315	cyclic pyranopterin monophosphate synthase activity
MS6_0820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MS6_0821	COG0314	molybdopterin synthase activity
MS6_0822	COG2199	diguanylate cyclase activity
MS6_0823	COG4109	DRTGG domain
MS6_0825	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MS6_0827	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_0827	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_0828	COG0489	protein tyrosine kinase activity
MS6_0829	COG0572	uridine kinase
MS6_0830	COG2982	Protein involved in outer membrane biogenesis
MS6_0831	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MS6_0832	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MS6_0834	COG2067	long-chain fatty acid transport protein
MS6_0838	COG0183	Belongs to the thiolase family
MS6_0839	COG1250	3-hydroxyacyl-CoA dehydrogenase
MS6_0839	COG1024	Enoyl-CoA hydratase
MS6_0840	COG0778	Nitroreductase
MS6_0841	COG0583	DNA-binding transcription factor activity
MS6_0842	COG0745	RESPONSE REGULATOR receiver
MS6_0845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MS6_0847	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MS6_0848	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MS6_0851	COG1028	Short-chain dehydrogenase reductase Sdr
MS6_0852	COG0616	signal peptide processing
MS6_0854	COG1522	sequence-specific DNA binding
MS6_0855	COG1946	Acyl-CoA thioesterase
MS6_0859	COG3706	GGDEF domain
MS6_0860	COG0640	Transcriptional regulator
MS6_0861	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MS6_0867	COG1881	PFAM PEBP family protein
MS6_0871	COG0009	L-threonylcarbamoyladenylate synthase
MS6_0874	COG2201	protein-glutamate methylesterase activity
MS6_0876	COG5002	protein histidine kinase activity
MS6_0877	COG4191	Histidine kinase
MS6_0878	COG5001	Diguanylate cyclase
MS6_0878	COG3300	MHYT domain
MS6_0879	COG2204	response regulator
MS6_0883	COG0601	transmembrane transport
MS6_0884	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MS6_0885	COG0444	Belongs to the ABC transporter superfamily
MS6_0886	COG4608	Belongs to the ABC transporter superfamily
MS6_0887	COG0435	Glutathione S-transferase
MS6_0888	COG0857	belongs to the CobB CobQ family
MS6_0888	COG0280	phosphate acetyltransferase
MS6_0889	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MS6_0890	COG3092	negative regulation of chromosome organization
MS6_0891	COG4628	conserved protein (DUF2132)
MS6_0893	COG4120	Belongs to the binding-protein-dependent transport system permease family
MS6_0895	COG2203	Gaf domain
MS6_0895	COG2199	diguanylate cyclase activity
MS6_0896	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MS6_0898	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MS6_0899	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MS6_0900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MS6_0901	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MS6_0902	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MS6_0903	COG0156	8-amino-7-oxononanoate synthase activity
MS6_0904	COG2226	methyltransferase
MS6_0905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MS6_0907	COG0501	Belongs to the peptidase M48B family
MS6_0909	COG0300	oxidoreductase activity
MS6_0912	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MS6_0914	COG2268	Band 7 protein
MS6_0916	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MS6_0917	COG2915	High frequency lysogenization protein hflD homolog
MS6_0918	COG0482	sulfurtransferase activity
MS6_0919	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MS6_0920	COG2916	Histone family protein nucleoid-structuring protein H-NS
MS6_0921	COG1757	Na H antiporter
MS6_0922	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MS6_0923	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MS6_0924	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MS6_0925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MS6_0925	COG0131	Imidazoleglycerol-phosphate dehydratase
MS6_0926	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MS6_0927	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MS6_0928	COG0107	imidazoleglycerol-phosphate synthase activity
MS6_0929	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MS6_0929	COG0140	phosphoribosyl-ATP diphosphatase activity
MS6_0930	COG1187	pseudouridine synthase activity
MS6_0932	COG1278	Cold shock
MS6_0933	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MS6_0934	COG0542	response to heat
MS6_0936	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MS6_0937	COG1012	belongs to the aldehyde dehydrogenase family
MS6_0937	COG1454	alcohol dehydrogenase
MS6_0938	COG1737	Transcriptional regulator
MS6_0940	COG0076	glutamate decarboxylase activity
MS6_0942	COG2431	L-lysine efflux transmembrane transporter activity
MS6_0944	COG3070	regulator of competence-specific genes
MS6_0947	COG3852	Histidine kinase
MS6_0949	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MS6_0952	COG0189	ligase activity
MS6_0952	COG4067	protein conserved in archaea
MS6_0953	COG0500	methyltransferase
MS6_0954	COG4106	trans-aconitate 2-methyltransferase activity
MS6_0955	COG1801	Protein of unknown function DUF72
MS6_0956	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MS6_0957	COG1435	thymidine kinase activity
MS6_0958	COG1301	dicarboxylic acid transport
MS6_0959	COG0159	tryptophan synthase activity
MS6_0960	COG0133	tryptophan synthase activity
MS6_0961	COG0134	indole-3-glycerol-phosphate synthase activity
MS6_0961	COG0135	phosphoribosylanthranilate isomerase activity
MS6_0962	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MS6_0963	COG0512	Glutamine amidotransferase of anthranilate synthase
MS6_0964	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MS6_0966	COG0613	PHP domain protein
MS6_0967	COG0009	L-threonylcarbamoyladenylate synthase
MS6_0968	COG1187	pseudouridine synthase activity
MS6_0969	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MS6_0970	COG4988	ABC transporter
MS6_0971	COG0492	ferredoxin-NADP+ reductase activity
MS6_0973	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MS6_0974	COG3706	GGDEF domain
MS6_0974	COG0745	RESPONSE REGULATOR receiver
MS6_0975	COG2949	membrane
MS6_0977	COG0281	malic enzyme
MS6_0979	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MS6_0983	COG2885	chlorophyll binding
MS6_0986	COG0247	lactate metabolic process
MS6_0986	COG0277	FAD linked oxidase domain protein
MS6_0990	COG2986	histidine ammonia-lyase
MS6_0991	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MS6_0992	COG0010	Belongs to the arginase family
MS6_0993	COG1228	amidohydrolase
MS6_0997	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MS6_0999	COG5001	Diguanylate cyclase
MS6_1000	COG0417	DNA replication proofreading
MS6_1001	COG2197	response regulator
MS6_1002	COG0322	excinuclease ABC activity
MS6_1004	COG3706	GGDEF domain
MS6_1004	COG0745	RESPONSE REGULATOR receiver
MS6_1007	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MS6_1008	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_1008	COG0072	phenylalanine-tRNA ligase activity
MS6_1009	COG0776	regulation of translation
MS6_1011	COG0500	methyltransferase
MS6_1012	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MS6_1014	COG0295	cytidine deaminase activity
MS6_1015	COG1346	cytolysis
MS6_1017	COG2925	Exonuclease
MS6_1019	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_1021	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MS6_1022	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MS6_1025	COG2988	succinylglutamate desuccinylase activity
MS6_1026	COG4139	cobalamin transport
MS6_1027	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
MS6_1036	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MS6_1037	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MS6_1038	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MS6_1042	COG2814	Major facilitator Superfamily
MS6_1044	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MS6_1049	COG2989	Protein conserved in bacteria
MS6_1050	COG3108	Peptidase M15
MS6_1051	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MS6_1054	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MS6_1059	COG1846	Transcriptional regulator
MS6_1060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MS6_1061	COG0726	polysaccharide deacetylase
MS6_1062	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MS6_1064	COG1447	Phosphotransferase system cellobiose-specific component IIA
MS6_1065	COG1486	melibiose metabolic process
MS6_1066	COG3394	polysaccharide catabolic process
MS6_1067	COG1609	Transcriptional regulator
MS6_1068	COG2943	transferase activity, transferring hexosyl groups
MS6_1069	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MS6_1070	COG0840	transmembrane signaling receptor activity
MS6_1073	COG1448	Aminotransferase
MS6_1075	COG2770	Histidine kinase
MS6_1075	COG3437	response regulator, receiver
MS6_1076	COG0351	phosphomethylpyrimidine kinase
MS6_1077	COG0017	Asparaginyl-tRNA synthetase
MS6_1079	COG0720	synthase
MS6_1080	COG1760	l-serine dehydratase
MS6_1081	COG0814	amino acid
MS6_1082	COG0494	nUDIX hydrolase
MS6_1083	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MS6_1086	COG3106	COG3106 Predicted ATPase
MS6_1087	COG3768	UPF0283 membrane protein
MS6_1088	COG3283	Transcriptional regulator of aromatic amino acids metabolism
MS6_1089	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_1092	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MS6_1094	COG0471	metal ion transport
MS6_1095	COG4191	Histidine kinase
MS6_1095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MS6_1097	COG2990	Protein conserved in bacteria
MS6_1098	COG3713	MltA-interacting MipA family protein
MS6_1099	COG2205	protein histidine kinase activity
MS6_1100	COG0745	RESPONSE REGULATOR receiver
MS6_1106	COG1129	ABC transporter
MS6_1113	COG2186	Transcriptional regulator
MS6_1114	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MS6_1115	COG0372	Belongs to the citrate synthase family
MS6_1121	COG2195	Cleaves the N-terminal amino acid of tripeptides
MS6_1123	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MS6_1125	COG0625	glutathione transferase activity
MS6_1126	COG3437	response regulator, receiver
MS6_1127	COG3850	Histidine kinase
MS6_1127	COG4999	Histidine kinase
MS6_1127	COG3437	response regulator, receiver
MS6_1127	COG2205	protein histidine kinase activity
MS6_1129	COG3706	GGDEF domain
MS6_1130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MS6_1131	COG1254	Belongs to the acylphosphatase family
MS6_1132	COG2920	part of a sulfur-relay system
MS6_1133	COG0670	Belongs to the BI1 family
MS6_1134	COG1126	abc transporter atp-binding protein
MS6_1135	COG0765	amino acid transport
MS6_1136	COG4597	amino acid ABC transporter
MS6_1137	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MS6_1139	COG0561	phosphatase activity
MS6_1140	COG0602	queuosine metabolic process
MS6_1141	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MS6_1147	COG3706	GGDEF domain
MS6_1148	COG0443	Heat shock 70 kDa protein
MS6_1157	COG1643	Atp-dependent helicase
MS6_1159	COG0443	Heat shock 70 kDa protein
MS6_1160	COG0095	Lipoate-protein ligase
MS6_1162	COG0583	DNA-binding transcription factor activity
MS6_1163	COG0477	Major facilitator Superfamily
MS6_1164	COG0415	Belongs to the DNA photolyase family
MS6_1165	COG2076	Multidrug Resistance protein
MS6_1169	COG2198	Histidine kinase
MS6_1169	COG0643	Histidine kinase
MS6_1171	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MS6_1173	COG2201	protein-glutamate methylesterase activity
MS6_1174	COG0835	chemotaxis
MS6_1175	COG3290	protein histidine kinase activity
MS6_1175	COG0840	transmembrane signaling receptor activity
MS6_1177	COG0840	transmembrane signaling receptor activity
MS6_1179	COG0513	Belongs to the DEAD box helicase family
MS6_1181	COG1538	Outer membrane efflux protein
MS6_1182	COG1566	PFAM secretion protein HlyD family protein
MS6_1183	COG2814	Major facilitator Superfamily
MS6_1184	COG0840	transmembrane signaling receptor activity
MS6_1185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MS6_1187	COG3501	Rhs element vgr protein
MS6_1192	COG1280	lysine exporter protein (LysE YggA)
MS6_1193	COG1115	amino acid carrier protein
MS6_1196	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MS6_1197	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MS6_1198	COG1177	transmembrane transport
MS6_1199	COG1176	ABC-type spermidine putrescine transport system, permease component I
MS6_1200	COG3842	ATPase activity
MS6_1204	COG0037	tRNA processing
MS6_1205	COG0589	response to stress
MS6_1206	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MS6_1209	COG2217	Heavy metal translocating P-type atpase
MS6_1211	COG2010	Cytochrome c
MS6_1214	COG3278	Belongs to the heme-copper respiratory oxidase family
MS6_1216	COG0784	Response regulator, receiver
MS6_1216	COG2205	protein histidine kinase activity
MS6_1221	COG2994	toxin metabolic process
MS6_1222	COG1073	alpha beta
MS6_1222	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MS6_1222	COG3064	Membrane
MS6_1232	COG4128	Pfam Zonular occludens toxin
MS6_1239	COG1476	TRANSCRIPTIONal
MS6_1243	COG4128	Pfam Zonular occludens toxin
MS6_1250	COG1476	TRANSCRIPTIONal
MS6_1268	COG3120	sequence-specific DNA binding
MS6_1269	COG1067	ATP-dependent peptidase activity
MS6_1270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MS6_1274	COG0116	Belongs to the methyltransferase superfamily
MS6_1274	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MS6_1277	COG0167	dihydroorotate dehydrogenase activity
MS6_1280	COG0308	aminopeptidase N
MS6_1283	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MS6_1284	COG1956	GAF domain-containing protein
MS6_1285	COG1132	(ABC) transporter
MS6_1286	COG2995	paraquat-inducible protein a
MS6_1287	COG3008	intermembrane lipid transfer
MS6_1288	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MS6_1288	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MS6_1289	COG2996	Protein conserved in bacteria
MS6_1292	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MS6_1294	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MS6_1297	COG0437	4 iron, 4 sulfur cluster binding
MS6_1298	COG0243	molybdopterin cofactor binding
MS6_1298	COG3383	formate dehydrogenase (NAD+) activity
MS6_1304	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MS6_1305	COG0488	(ABC) transporter
MS6_1306	COG3852	Histidine kinase
MS6_1307	COG2204	response regulator
MS6_1309	COG4662	Binding-protein-dependent transport system inner membrane component
MS6_1310	COG3842	ATPase activity
MS6_1311	COG0746	molybdenum cofactor guanylyltransferase activity
MS6_1312	COG0303	'Molybdopterin
MS6_1317	COG1940	carbohydrate kinase activity
MS6_1320	COG0840	transmembrane signaling receptor activity
MS6_1321	COG0791	NLP P60 protein
MS6_1325	COG0534	Mate efflux family protein
MS6_1327	COG1793	dna ligase
MS6_1329	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MS6_1330	COG0848	biopolymer transport protein
MS6_1331	COG0811	peptide transport
MS6_1332	COG0811	peptide transport
MS6_1335	COG1175	transmembrane transport
MS6_1336	COG0395	ABC-type sugar transport system, permease component
MS6_1337	COG3842	ATPase activity
MS6_1338	COG1349	DNA-binding transcription factor activity
MS6_1339	COG0584	glycerophosphoryl diester phosphodiesterase
MS6_1340	COG2731	YhcH YjgK YiaL family protein
MS6_1341	COG0251	oxidation-reduction process
MS6_1343	COG1609	Transcriptional regulator
MS6_1344	COG2723	6-phospho-beta-galactosidase activity
MS6_1345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MS6_1346	COG0583	DNA-binding transcription factor activity
MS6_1350	COG1136	(ABC) transporter
MS6_1350	COG0577	efflux transmembrane transporter activity
MS6_1351	COG1136	(ABC) transporter
MS6_1351	COG0577	efflux transmembrane transporter activity
MS6_1352	COG4591	ABC-type transport system involved in lipoprotein release permease component
MS6_1352	COG1136	(ABC) transporter
MS6_1353	COG1294	oxidase, subunit
MS6_1354	COG1271	oxidase subunit
MS6_1362	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MS6_1364	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MS6_1368	COG0753	catalase activity
MS6_1371	COG3527	Alpha-acetolactate decarboxylase
MS6_1374	COG2199	diguanylate cyclase activity
MS6_1374	COG2200	EAL domain
MS6_1375	COG3706	GGDEF domain
MS6_1376	COG2017	converts alpha-aldose to the beta-anomer
MS6_1377	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MS6_1378	COG1085	galactose-1-phosphate uridylyltransferase
MS6_1381	COG0745	RESPONSE REGULATOR receiver
MS6_1381	COG3706	GGDEF domain
MS6_1384	COG0835	chemotaxis
MS6_1384	COG0784	Response regulator, receiver
MS6_1386	COG4565	transcriptional regulatory protein
MS6_1387	COG3290	protein histidine kinase activity
MS6_1389	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_1393	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MS6_1394	COG3063	Type IV pilus biogenesis stability protein PilW
MS6_1397	COG1451	nucleotide metabolic process
MS6_1399	COG0583	DNA-binding transcription factor activity
MS6_1403	COG1538	Outer membrane efflux protein
MS6_1405	COG0019	diaminopimelate decarboxylase activity
MS6_1406	COG1748	Saccharopine dehydrogenase
MS6_1408	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MS6_1411	COG4181	ATPase activity
MS6_1412	COG0534	Mate efflux family protein
MS6_1413	COG0702	epimerase
MS6_1415	COG2814	Major facilitator Superfamily
MS6_1416	COG1187	pseudouridine synthase activity
MS6_1417	COG1061	Type III restriction enzyme res subunit
MS6_1421	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MS6_1422	COG5001	Diguanylate cyclase
MS6_1422	COG4251	negative regulation of phosphorylation
MS6_1422	COG3706	GGDEF domain
MS6_1422	COG2203	Gaf domain
MS6_1424	COG0840	transmembrane signaling receptor activity
MS6_1430	COG4934	collagen metabolic process
MS6_1434	COG2239	Acts as a magnesium transporter
MS6_1437	COG0814	amino acid
MS6_1438	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_1439	COG1131	(ABC) transporter
MS6_1440	COG0842	Transport permease protein
MS6_1442	COG3313	Fe-S protein
MS6_1444	COG4134	Bacterial extracellular solute-binding protein
MS6_1445	COG4135	transport system, permease component
MS6_1446	COG4136	ATPase activity
MS6_1447	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MS6_1448	COG0564	pseudouridine synthase activity
MS6_1450	COG0733	neurotransmitter:sodium symporter activity
MS6_1452	COG0626	cystathionine gamma-synthase activity
MS6_1453	COG2818	Glycosylase
MS6_1456	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_1459	COG1842	Phage shock protein A
MS6_1460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MS6_1462	COG4168	peptide transport system, permease
MS6_1463	COG4171	peptide transport system, permease
MS6_1465	COG4172	Belongs to the ABC transporter superfamily
MS6_1468	COG1227	inorganic diphosphatase activity
MS6_1471	COG0243	molybdopterin cofactor binding
MS6_1472	COG3005	denitrification pathway
MS6_1473	COG4459	periplasmic nitrate reductase
MS6_1475	COG2116	formate transmembrane transporter activity
MS6_1477	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MS6_1478	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MS6_1480	COG2917	probably involved in intracellular septation
MS6_1481	COG1607	acyl-coa hydrolase
MS6_1482	COG2350	Protein conserved in bacteria
MS6_1484	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MS6_1485	COG0583	DNA-binding transcription factor activity
MS6_1488	COG0612	Peptidase, M16
MS6_1489	COG5001	Diguanylate cyclase
MS6_1490	COG1032	radical SAM domain protein
MS6_1493	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MS6_1494	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MS6_1495	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
MS6_1496	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MS6_1497	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MS6_1498	COG0745	RESPONSE REGULATOR receiver
MS6_1500	COG1609	Transcriptional regulator
MS6_1501	COG3070	regulator of competence-specific genes
MS6_1505	COG0297	glycogen (starch) synthase activity
MS6_1506	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MS6_1508	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MS6_1510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MS6_1512	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MS6_1513	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MS6_1514	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MS6_1515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MS6_1516	COG1960	acyl-CoA dehydrogenase activity
MS6_1521	COG1012	belongs to the aldehyde dehydrogenase family
MS6_1522	COG1309	transcriptional regulator
MS6_1526	COG0668	transmembrane transport
MS6_1527	COG2995	paraquat-inducible protein a
MS6_1528	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MS6_1528	COG3008	intermembrane lipid transfer
MS6_1530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_1531	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_1532	COG0582	viral genome integration into host DNA
MS6_1533	COG0582	viral genome integration into host DNA
MS6_1534	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MS6_1538	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MS6_1542	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MS6_1546	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
MS6_1547	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
MS6_1548	COG1737	Transcriptional regulator
MS6_1549	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MS6_1550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MS6_1551	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MS6_1552	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MS6_1553	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MS6_1554	COG1940	carbohydrate kinase activity
MS6_1555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MS6_1556	COG4409	exo-alpha-(2->6)-sialidase activity
MS6_1558	COG2003	Belongs to the UPF0758 family
MS6_1563	COG3941	tape measure
MS6_1569	COG0488	(ABC) transporter
MS6_1582	COG0415	Belongs to the DNA photolyase family
MS6_1584	COG4628	conserved protein (DUF2132)
MS6_1585	COG3284	Transcriptional regulator
MS6_1586	COG1012	belongs to the aldehyde dehydrogenase family
MS6_1588	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_1589	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_1590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_1592	COG2207	Transcriptional regulator
MS6_1593	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_1593	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_1593	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_1594	COG1482	cell wall glycoprotein biosynthetic process
MS6_1596	COG0784	Response regulator, receiver
MS6_1596	COG5002	protein histidine kinase activity
MS6_1598	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MS6_1600	COG2885	chlorophyll binding
MS6_1601	COG0823	Involved in the tonB-independent uptake of proteins
MS6_1604	COG0811	peptide transport
MS6_1605	COG0824	Thioesterase
MS6_1606	COG1294	oxidase, subunit
MS6_1607	COG1271	oxidase subunit
MS6_1608	COG2255	four-way junction helicase activity
MS6_1609	COG0632	four-way junction helicase activity
MS6_1610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MS6_1611	COG0215	cysteine-tRNA ligase activity
MS6_1612	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MS6_1613	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_1614	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MS6_1616	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MS6_1617	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MS6_1618	COG1199	ATP-dependent helicase activity
MS6_1619	COG0730	response to heat
MS6_1620	COG3923	Primosomal replication protein n
MS6_1622	COG0840	transmembrane signaling receptor activity
MS6_1623	COG0708	Exodeoxyribonuclease III
MS6_1624	COG4160	amino acid transport
MS6_1625	COG4215	(ABC) transporter
MS6_1629	COG1882	Formate acetyltransferase
MS6_1631	COG0840	transmembrane signaling receptor activity
MS6_1632	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MS6_1634	COG3013	Belongs to the UPF0304 family
MS6_1635	COG2766	serine protein kinase
MS6_1636	COG2718	Belongs to the UPF0229 family
MS6_1637	COG2719	SpoVR family
MS6_1638	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MS6_1640	COG1663	tetraacyldisaccharide 4'-kinase activity
MS6_1641	COG1132	(ABC) transporter
MS6_1642	COG2333	competence protein COMEC
MS6_1642	COG0658	competence protein
MS6_1644	COG4591	ABC-type transport system involved in lipoprotein release permease component
MS6_1645	COG1136	(ABC) transporter
MS6_1646	COG4591	ABC-type transport system involved in lipoprotein release permease component
MS6_1648	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MS6_1652	COG1252	NADH dehydrogenase
MS6_1659	COG0537	adenosine 5'-monophosphoramidase activity
MS6_1662	COG2186	Transcriptional regulator
MS6_1663	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MS6_1664	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MS6_1665	COG1674	ftsk spoiiie
MS6_1667	COG0686	Belongs to the AlaDH PNT family
MS6_1669	COG0583	DNA-binding transcription factor activity
MS6_1673	COG0284	orotidine-5'-phosphate decarboxylase activity
MS6_1674	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MS6_1675	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
MS6_1676	COG0776	regulation of translation
MS6_1677	COG0539	negative regulation of cytoplasmic translation
MS6_1678	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MS6_1679	COG1555	photosystem II stabilization
MS6_1680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MS6_1681	COG0776	regulation of translation
MS6_1682	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MS6_1683	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MS6_1685	COG0544	peptidyl-prolyl cis-trans isomerase activity
MS6_1687	COG4191	Histidine kinase
MS6_1689	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MS6_1690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MS6_1691	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MS6_1692	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MS6_1695	COG5001	Diguanylate cyclase
MS6_1695	COG3300	MHYT domain
MS6_1697	COG4589	Belongs to the CDS family
MS6_1703	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MS6_1706	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_1709	COG0243	molybdopterin cofactor binding
MS6_1710	COG3005	denitrification pathway
MS6_1711	COG3469	chitinase activity
MS6_1711	COG3325	Belongs to the glycosyl hydrolase 18 family
MS6_1712	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MS6_1714	COG2951	lytic endotransglycosylase activity
MS6_1715	COG3100	YcgL domain-containing protein
MS6_1716	COG0850	regulation of cytokinetic process
MS6_1717	COG2894	cell division
MS6_1718	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MS6_1719	COG3015	lipoprotein NlpE involved in copper resistance
MS6_1723	COG0477	Major facilitator Superfamily
MS6_1725	COG0840	transmembrane signaling receptor activity
MS6_1726	COG1396	sequence-specific DNA binding
MS6_1727	COG3135	benzoate transporter
MS6_1729	COG1441	menaquinone biosynthetic process
MS6_1731	COG0596	Alpha beta hydrolase
MS6_1732	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MS6_1733	COG1169	isochorismate synthase
MS6_1734	COG0436	Aminotransferase
MS6_1735	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MS6_1736	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MS6_1740	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MS6_1741	COG0318	PFAM AMP-dependent synthetase and ligase
MS6_1742	COG0596	Alpha beta hydrolase
MS6_1745	COG1214	PFAM Peptidase M22, glycoprotease
MS6_1746	COG1199	ATP-dependent helicase activity
MS6_1748	COG0788	formyltetrahydrofolate deformylase activity
MS6_1749	COG0446	pyridine nucleotide-disulphide oxidoreductase
MS6_1749	COG1902	pentaerythritol trinitrate reductase activity
MS6_1750	COG0616	signal peptide processing
MS6_1751	COG0252	asparaginase activity
MS6_1753	COG3139	Protein of unknown function (DUF1315)
MS6_1756	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_1757	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MS6_1758	COG0676	glucose-6-phosphate 1-epimerase activity
MS6_1760	COG2226	methyltransferase
MS6_1763	COG0784	Response regulator, receiver
MS6_1763	COG0835	chemotaxis
MS6_1764	COG1940	carbohydrate kinase activity
MS6_1766	COG4667	esterase of the alpha-beta hydrolase superfamily
MS6_1769	COG0733	neurotransmitter:sodium symporter activity
MS6_1770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_1770	COG1263	PTS System
MS6_1771	COG0084	hydrolase, TatD family'
MS6_1773	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MS6_1774	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MS6_1775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MS6_1776	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MS6_1777	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MS6_1778	COG1028	Short-chain dehydrogenase reductase Sdr
MS6_1779	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MS6_1780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MS6_1781	COG0416	fatty acid biosynthetic process
MS6_1782	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MS6_1783	COG1399	metal-binding, possibly nucleic acid-binding protein
MS6_1790	COG0424	maF-like protein
MS6_1791	COG0564	pseudouridine synthase activity
MS6_1792	COG1530	ribonuclease E activity
MS6_1793	COG0659	secondary active sulfate transmembrane transporter activity
MS6_1795	COG1012	belongs to the aldehyde dehydrogenase family
MS6_1795	COG1454	alcohol dehydrogenase
MS6_1796	COG2095	MarC family integral membrane protein
MS6_1797	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MS6_1798	COG1757	Na H antiporter
MS6_1800	COG3081	Nucleoid-associated protein
MS6_1802	COG3083	sulfuric ester hydrolase activity
MS6_1803	COG0123	including yeast histone deacetylase and acetoin utilization protein
MS6_1804	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MS6_1805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MS6_1810	COG2853	Lipoprotein
MS6_1813	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MS6_1814	COG1138	Cytochrome C-type biogenesis protein
MS6_1815	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MS6_1817	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MS6_1818	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MS6_1819	COG4133	protoheme IX ABC transporter activity
MS6_1821	COG0835	chemotaxis
MS6_1823	COG1192	Involved in chromosome partitioning
MS6_1824	COG2201	protein-glutamate methylesterase activity
MS6_1825	COG0643	Histidine kinase
MS6_1825	COG2198	Histidine kinase
MS6_1826	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MS6_1829	COG0455	bacterial-type flagellum organization
MS6_1832	COG2062	phosphohistidine phosphatase, SixA
MS6_1833	COG1025	Belongs to the peptidase M16 family
MS6_1835	COG0018	arginyl-trna synthetase
MS6_1839	COG1918	ferrous iron import across plasma membrane
MS6_1840	COG4977	sequence-specific DNA binding
MS6_1841	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MS6_1842	COG1121	(ABC) transporter
MS6_1843	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MS6_1845	COG0045	succinate-CoA ligase (ADP-forming) activity
MS6_1846	COG0508	dehydrogenase complex catalyzes the overall conversion of
MS6_1847	COG0567	Dehydrogenase, E1 component
MS6_1849	COG1053	succinate dehydrogenase
MS6_1850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MS6_1851	COG2009	succinate dehydrogenase
MS6_1852	COG0372	Belongs to the citrate synthase family
MS6_1853	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MS6_1855	COG0033	Phosphoglucomutase
MS6_1856	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MS6_1857	COG0596	Alpha beta hydrolase
MS6_1860	COG1346	cytolysis
MS6_1862	COG0583	DNA-binding transcription factor activity
MS6_1864	COG0735	belongs to the Fur family
MS6_1865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MS6_1866	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MS6_1867	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MS6_1868	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MS6_1868	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MS6_1869	COG0431	NADPH-dependent FMN reductase
MS6_1871	COG3101	peptidyl-lysine hydroxylation
MS6_1872	COG2860	membrane
MS6_1873	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MS6_1874	COG2890	protein-(glutamine-N5) methyltransferase activity
MS6_1876	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MS6_1877	COG1684	flagellar biosynthetic protein fliR
MS6_1878	COG1987	bacterial-type flagellum assembly
MS6_1884	COG1580	Controls the rotational direction of flagella during chemotaxis
MS6_1889	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MS6_1891	COG1677	Flagellar hook-basal body complex protein FliE
MS6_1892	COG2204	response regulator
MS6_1893	COG4191	Histidine kinase
MS6_1894	COG2204	response regulator
MS6_1895	COG1516	flagellar protein fliS
MS6_1897	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MS6_1898	COG1334	flagellar protein FlaG
MS6_1899	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_1900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_1901	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_1902	COG2837	iron assimilation
MS6_1906	COG1393	Belongs to the ArsC family
MS6_1907	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MS6_1908	COG1876	peptidase activity
MS6_1910	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MS6_1911	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MS6_1913	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MS6_1917	COG4783	chaperone-mediated protein folding
MS6_1918	COG1393	Belongs to the ArsC family
MS6_1922	COG2233	PERMEase
MS6_1923	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MS6_1924	COG0737	Belongs to the 5'-nucleotidase family
MS6_1925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MS6_1926	COG2912	Transglutaminase-like superfamily
MS6_1927	COG3094	Invasion gene expression up-regulator, SirB
MS6_1928	COG2890	protein-(glutamine-N5) methyltransferase activity
MS6_1929	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MS6_1930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MS6_1931	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MS6_1932	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MS6_1933	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MS6_1934	COG0193	aminoacyl-tRNA hydrolase activity
MS6_1935	COG0012	GTP binding
MS6_1936	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_1937	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_1940	COG3951	Flagellar rod assembly protein muramidase FlgJ
MS6_1940	COG1705	Flagellar rod assembly protein muramidase FlgJ
MS6_1941	COG1706	bacterial-type flagellum-dependent cell motility
MS6_1942	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MS6_1943	COG4786	Flagellar basal body rod
MS6_1944	COG4787	bacterial-type flagellum-dependent cell motility
MS6_1945	COG1749	Flagellar hook protein flgE
MS6_1946	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MS6_1947	COG1558	bacterial-type flagellum-dependent cell motility
MS6_1948	COG1815	bacterial-type flagellum-dependent cell motility
MS6_1949	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MS6_1950	COG0784	Response regulator, receiver
MS6_1950	COG0835	chemotaxis
MS6_1957	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MS6_1957	COG2226	methyltransferase
MS6_1957	COG3433	isochorismatase activity
MS6_1958	COG2375	cellular response to nickel ion
MS6_1959	COG1629	transport
MS6_1959	COG4774	siderophore transport
MS6_1962	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MS6_1963	COG2217	Heavy metal translocating P-type atpase
MS6_1963	COG2608	mercury ion transmembrane transporter activity
MS6_1968	COG3735	TraB family
MS6_1970	COG2840	Smr protein MutS2
MS6_1971	COG1187	pseudouridine synthase activity
MS6_1972	COG3706	GGDEF domain
MS6_1973	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MS6_1974	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MS6_1975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MS6_1976	COG0121	glutamine amidotransferase
MS6_1977	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MS6_1978	COG1960	acyl-CoA dehydrogenase activity
MS6_1980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MS6_1981	COG0328	RNA-DNA hybrid ribonuclease activity
MS6_1982	COG2226	methyltransferase
MS6_1983	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MS6_1984	COG1388	LysM domain
MS6_1984	COG0741	lytic transglycosylase activity
MS6_1986	COG0347	Belongs to the P(II) protein family
MS6_1987	COG3479	Phenolic acid decarboxylase
MS6_1989	COG0037	tRNA processing
MS6_1990	COG0825	malonyl-CoA metabolic process
MS6_1991	COG0587	DNA-directed DNA polymerase activity
MS6_1992	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MS6_1993	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_1994	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_1995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MS6_1996	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_1997	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
MS6_1999	COG0750	zinc metalloprotease
MS6_2000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MS6_2001	COG0575	Belongs to the CDS family
MS6_2002	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MS6_2003	COG0233	cytoplasmic translational termination
MS6_2004	COG0528	UMP kinase activity
MS6_2005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MS6_2006	COG0052	Belongs to the universal ribosomal protein uS2 family
MS6_2007	COG0024	Methionine aminopeptidase
MS6_2008	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MS6_2010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MS6_2011	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MS6_2012	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MS6_2013	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MS6_2016	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MS6_2016	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MS6_2017	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MS6_2018	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MS6_2019	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MS6_2022	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MS6_2023	COG2252	PERMEase
MS6_2024	COG2195	Cleaves the N-terminal amino acid of tripeptides
MS6_2025	COG0189	ligase activity
MS6_2025	COG4067	protein conserved in archaea
MS6_2026	COG0189	ligase activity
MS6_2028	COG0733	neurotransmitter:sodium symporter activity
MS6_2029	COG3706	GGDEF domain
MS6_2031	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MS6_2033	COG1477	protein flavinylation
MS6_2034	COG2871	sodium ion transport
MS6_2035	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_2036	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_2037	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_2038	COG1805	sodium ion transport
MS6_2039	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_2040	COG0271	Belongs to the BolA IbaG family
MS6_2041	COG2813	Specifically methylates the guanine in position
MS6_2043	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MS6_2044	COG2211	Major facilitator Superfamily
MS6_2046	COG1595	DNA-templated transcription, initiation
MS6_2048	COG3248	Nucleoside-binding outer membrane protein
MS6_2049	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MS6_2050	COG0693	protein deglycase activity
MS6_2051	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MS6_2052	COG2166	iron-sulfur cluster assembly
MS6_2053	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MS6_2054	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MS6_2056	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MS6_2056	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MS6_2058	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MS6_2059	COG1074	ATP-dependent DNA helicase activity
MS6_2060	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MS6_2063	COG3141	response to X-ray
MS6_2064	COG2171	N-acyltransferase activity
MS6_2066	COG0456	acetyltransferase
MS6_2067	COG0189	ligase activity
MS6_2067	COG0569	domain protein
MS6_2070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_2071	COG1609	Transcriptional regulator
MS6_2072	COG3250	beta-galactosidase activity
MS6_2075	COG1022	Amp-dependent synthetase and ligase
MS6_2076	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MS6_2077	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MS6_2079	COG0560	Phosphoserine phosphatase
MS6_2081	COG0813	purine-nucleoside phosphorylase activity
MS6_2082	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MS6_2083	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MS6_2084	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MS6_2086	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MS6_2087	COG0084	hydrolase, TatD family'
MS6_2090	COG1115	amino acid carrier protein
MS6_2093	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MS6_2094	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MS6_2095	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
MS6_2096	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MS6_2097	COG0083	homoserine kinase activity
MS6_2100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MS6_2102	COG0745	RESPONSE REGULATOR receiver
MS6_2103	COG0784	Response regulator, receiver
MS6_2103	COG2198	Histidine kinase
MS6_2103	COG5002	protein histidine kinase activity
MS6_2104	COG5001	Diguanylate cyclase
MS6_2104	COG2203	Gaf domain
MS6_2104	COG4251	negative regulation of phosphorylation
MS6_2104	COG3706	GGDEF domain
MS6_2105	COG1242	4 iron, 4 sulfur cluster binding
MS6_2107	COG0069	glutamate synthase activity
MS6_2107	COG0070	glutamate synthase
MS6_2107	COG0067	glutamate synthase
MS6_2109	COG0067	glutamate synthase
MS6_2109	COG0070	glutamate synthase
MS6_2109	COG0069	glutamate synthase activity
MS6_2110	COG0493	'glutamate synthase
MS6_2112	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MS6_2114	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MS6_2115	COG2860	membrane
MS6_2116	COG0730	response to heat
MS6_2118	COG4172	Belongs to the ABC transporter superfamily
MS6_2121	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MS6_2122	COG0505	Belongs to the CarA family
MS6_2124	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MS6_2125	COG0494	nUDIX hydrolase
MS6_2126	COG0653	protein targeting
MS6_2128	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MS6_2129	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MS6_2130	COG0849	cell division
MS6_2131	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MS6_2132	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MS6_2133	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MS6_2134	COG0772	Belongs to the SEDS family
MS6_2135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MS6_2136	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MS6_2137	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MS6_2138	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MS6_2139	COG0768	penicillin binding
MS6_2140	COG3116	cell division
MS6_2141	COG0275	rRNA processing
MS6_2142	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_2143	COG0508	dehydrogenase complex catalyzes the overall conversion of
MS6_2144	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MS6_2145	COG2186	Transcriptional regulator
MS6_2146	COG0737	Belongs to the 5'-nucleotidase family
MS6_2147	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MS6_2148	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MS6_2149	COG4974	Belongs to the 'phage' integrase family
MS6_2150	COG0716	FMN binding
MS6_2154	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_2155	COG1459	type II secretion system
MS6_2157	COG0237	dephospho-CoA kinase activity
MS6_2158	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MS6_2159	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MS6_2160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MS6_2161	COG0187	DNA topoisomerase II activity
MS6_2163	COG3150	esterase
MS6_2165	COG3151	Protein conserved in bacteria
MS6_2166	COG0494	nUDIX hydrolase
MS6_2167	COG1538	Outer membrane efflux protein
MS6_2169	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MS6_2170	COG0840	transmembrane signaling receptor activity
MS6_2171	COG3025	triphosphatase activity
MS6_2172	COG1392	Phosphate transport regulator
MS6_2173	COG0306	phosphate transporter
MS6_2174	COG4991	sh3 domain protein
MS6_2176	COG3267	Type II secretory pathway component ExeA
MS6_2176	COG3409	Peptidoglycan-binding domain 1 protein
MS6_2177	COG0617	tRNA 3'-terminal CCA addition
MS6_2178	COG0148	phosphopyruvate hydratase activity
MS6_2179	COG0504	CTP synthase activity
MS6_2181	COG3956	TIGRFAM MazG family protein
MS6_2182	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MS6_2183	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MS6_2189	COG0736	holo-[acyl-carrier-protein] synthase activity
MS6_2190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MS6_2191	COG1381	Involved in DNA repair and RecF pathway recombination
MS6_2192	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MS6_2193	COG0571	ribonuclease III activity
MS6_2194	COG0681	Belongs to the peptidase S26 family
MS6_2195	COG0481	GTPase activity
MS6_2196	COG3086	response to oxidative stress
MS6_2197	COG3026	antisigma factor binding
MS6_2199	COG1595	DNA-templated transcription, initiation
MS6_2200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MS6_2202	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MS6_2203	COG0354	folic acid binding
MS6_2205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_2206	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_2208	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MS6_2209	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MS6_2210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MS6_2211	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MS6_2212	COG0440	acetolactate synthase activity
MS6_2213	COG0028	Belongs to the TPP enzyme family
MS6_2214	COG1022	Amp-dependent synthetase and ligase
MS6_2215	COG0583	DNA-binding transcription factor activity
MS6_2219	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MS6_2220	COG0473	3-isopropylmalate dehydrogenase activity
MS6_2221	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MS6_2222	COG0066	3-isopropylmalate dehydratase activity
MS6_2224	COG3437	response regulator, receiver
MS6_2226	COG0795	lipopolysaccharide-transporting ATPase activity
MS6_2227	COG0795	lipopolysaccharide-transporting ATPase activity
MS6_2228	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MS6_2229	COG2927	DNA polymerase III (CHI subunit)
MS6_2230	COG0525	valine-tRNA ligase activity
MS6_2231	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MS6_2232	COG0564	pseudouridine synthase activity
MS6_2233	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MS6_2235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MS6_2236	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MS6_2237	COG0540	Belongs to the ATCase OTCase family
MS6_2238	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MS6_2239	COG0251	oxidation-reduction process
MS6_2240	COG0204	Acyl-transferase
MS6_2241	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MS6_2242	COG5007	Belongs to the BolA IbaG family
MS6_2244	COG2854	intermembrane phospholipid transfer
MS6_2245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MS6_2246	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MS6_2247	COG1127	ABC transporter
MS6_2249	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MS6_2249	COG0517	IMP dehydrogenase activity
MS6_2252	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MS6_2253	COG1137	ATPase activity
MS6_2255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MS6_2256	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_2258	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_2259	COG2239	Acts as a magnesium transporter
MS6_2260	COG0312	modulator of DNA gyrase
MS6_2261	COG3028	Belongs to the UPF0307 family
MS6_2262	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MS6_2263	COG1178	ABC-type Fe3 transport system permease component
MS6_2264	COG4143	(ABC) transporter
MS6_2265	COG0163	prenyltransferase activity
MS6_2266	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MS6_2267	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MS6_2268	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MS6_2269	COG2105	PFAM AIG2 family protein
MS6_2271	COG0729	surface antigen
MS6_2272	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_2273	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
MS6_2276	COG1136	(ABC) transporter
MS6_2280	COG0529	Catalyzes the synthesis of activated sulfate
MS6_2281	COG2895	sulfate adenylyltransferase (ATP) activity
MS6_2282	COG0175	sulfate reduction
MS6_2283	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MS6_2283	COG1648	precorrin-2 dehydrogenase activity
MS6_2284	COG0737	Belongs to the 5'-nucleotidase family
MS6_2286	COG0513	Belongs to the DEAD box helicase family
MS6_2287	COG2153	protein acetylation
MS6_2288	COG0697	spore germination
MS6_2290	COG0545	Peptidyl-prolyl cis-trans isomerase
MS6_2292	COG0203	ribosomal protein L17
MS6_2293	COG0202	RNA polymerase activity
MS6_2294	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MS6_2295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MS6_2296	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MS6_2298	COG0201	protein transport
MS6_2299	COG0200	Binds to the 23S rRNA
MS6_2300	COG1841	ribosomal large subunit assembly
MS6_2301	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MS6_2302	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MS6_2303	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MS6_2304	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MS6_2305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MS6_2306	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MS6_2307	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MS6_2308	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MS6_2309	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MS6_2310	COG0255	Belongs to the universal ribosomal protein uL29 family
MS6_2311	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MS6_2312	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MS6_2313	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MS6_2314	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MS6_2315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MS6_2316	COG0089	rRNA binding
MS6_2317	COG0088	Forms part of the polypeptide exit tunnel
MS6_2318	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MS6_2319	COG0051	transcription antitermination factor activity, RNA binding
MS6_2320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MS6_2321	COG0557	exoribonuclease II activity
MS6_2322	COG3083	sulfuric ester hydrolase activity
MS6_2323	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MS6_2324	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MS6_2326	COG1047	Peptidyl-prolyl cis-trans
MS6_2329	COG2249	NAD(P)H dehydrogenase (quinone) activity
MS6_2330	COG0488	(ABC) transporter
MS6_2332	COG0429	hydrolase of the alpha beta-hydrolase fold
MS6_2334	COG3954	Phosphoribulokinase
MS6_2335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MS6_2339	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MS6_2341	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MS6_2344	COG0180	Tryptophanyl-tRNA synthetase
MS6_2345	COG0546	phosphoglycolate phosphatase activity
MS6_2346	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MS6_2347	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MS6_2349	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MS6_2350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MS6_2356	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MS6_2358	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MS6_2358	COG0678	peroxiredoxin activity
MS6_2359	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_2361	COG0165	Argininosuccinate lyase
MS6_2362	COG0137	argininosuccinate synthase activity
MS6_2363	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MS6_2364	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MS6_2365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MS6_2366	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MS6_2368	COG1045	serine acetyltransferase
MS6_2369	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MS6_2370	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MS6_2371	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MS6_2372	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MS6_2373	COG1053	succinate dehydrogenase
MS6_2374	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MS6_2375	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MS6_2376	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MS6_2377	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MS6_2378	COG1509	lysine 2,3-aminomutase activity
MS6_2380	COG0459	protein refolding
MS6_2381	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MS6_2386	COG0149	triose-phosphate isomerase activity
MS6_2388	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MS6_2389	COG1575	Belongs to the MenA family. Type 1 subfamily
MS6_2390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MS6_2391	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MS6_2392	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MS6_2394	COG1609	Transcriptional regulator
MS6_2395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MS6_2396	COG0254	rRNA binding
MS6_2398	COG0281	malic enzyme
MS6_2399	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
MS6_2400	COG0626	cystathionine gamma-synthase activity
MS6_2401	COG0527	aspartate kinase activity
MS6_2401	COG0460	homoserine dehydrogenase
MS6_2402	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MS6_2403	COG3074	FtsZ-dependent cytokinesis
MS6_2404	COG1494	fructose-1,6-bisphosphatase
MS6_2405	COG0205	6-phosphofructokinase activity
MS6_2406	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MS6_2408	COG0745	RESPONSE REGULATOR receiver
MS6_2409	COG2205	protein histidine kinase activity
MS6_2411	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MS6_2412	COG3030	protein affecting phage T7 exclusion by the F plasmid
MS6_2413	COG3706	GGDEF domain
MS6_2414	COG1027	Aspartate ammonia-lyase
MS6_2415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MS6_2417	COG4232	protein-disulfide reductase activity
MS6_2419	COG3263	regulation of cellular component size
MS6_2421	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MS6_2422	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MS6_2423	COG0194	GDP metabolic process
MS6_2424	COG1758	RNA polymerase activity
MS6_2425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MS6_2426	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MS6_2427	COG2233	PERMEase
MS6_2429	COG0745	RESPONSE REGULATOR receiver
MS6_2430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MS6_2431	COG2183	response to ionizing radiation
MS6_2433	COG0596	Alpha beta hydrolase
MS6_2435	COG1040	competence protein
MS6_2436	COG0316	Belongs to the HesB IscA family
MS6_2436	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MS6_2437	COG0494	nUDIX hydrolase
MS6_2438	COG1218	3'(2'),5'-bisphosphate nucleotidase
MS6_2440	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MS6_2441	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MS6_2442	COG3156	type II secretion system protein K
MS6_2443	COG4795	General secretion pathway protein
MS6_2444	COG2165	general secretion pathway protein
MS6_2445	COG2165	general secretion pathway protein
MS6_2446	COG2165	general secretion pathway protein
MS6_2447	COG1459	type II secretion system
MS6_2448	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_2450	COG3031	protein transport across the cell outer membrane
MS6_2451	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MS6_2452	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MS6_2453	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MS6_2455	COG0456	acetyltransferase
MS6_2456	COG1490	D-aminoacyl-tRNA deacylase activity
MS6_2461	COG0174	glutamine synthetase
MS6_2463	COG3852	Histidine kinase
MS6_2465	COG5001	Diguanylate cyclase
MS6_2465	COG3300	MHYT domain
MS6_2466	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MS6_2468	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MS6_2469	COG1404	Belongs to the peptidase S8 family
MS6_2470	COG4206	TonB-dependent receptor
MS6_2471	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MS6_2474	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_2475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MS6_2476	COG2177	Part of the ABC transporter FtsEX involved in
MS6_2477	COG2884	Cell division ATP-binding protein ftsE
MS6_2478	COG0552	protein localization to endoplasmic reticulum
MS6_2479	COG0742	ribosomal rna small subunit methyltransferase
MS6_2485	COG0783	Belongs to the Dps family
MS6_2487	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MS6_2488	COG1280	lysine exporter protein (LysE YggA)
MS6_2489	COG2267	carboxylic ester hydrolase activity
MS6_2490	COG0561	phosphatase activity
MS6_2493	COG2199	diguanylate cyclase activity
MS6_2493	COG2200	EAL domain
MS6_2493	COG3287	FIST C domain
MS6_2494	COG1011	Hydrolase
MS6_2495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MS6_2497	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MS6_2498	COG0019	diaminopimelate decarboxylase activity
MS6_2500	COG1965	Belongs to the frataxin family
MS6_2501	COG3072	Adenylate cyclase
MS6_2503	COG0181	hydroxymethylbilane synthase activity
MS6_2504	COG1587	Uroporphyrinogen-III synthase
MS6_2505	COG2959	enzyme of heme biosynthesis
MS6_2506	COG3071	HemY protein
MS6_2507	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MS6_2509	COG3078	GTPase activator activity
MS6_2512	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MS6_2514	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MS6_2514	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MS6_2519	COG0084	hydrolase, TatD family'
MS6_2520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MS6_2522	COG0840	transmembrane signaling receptor activity
MS6_2523	COG1580	Controls the rotational direction of flagella during chemotaxis
MS6_2524	COG3161	chorismate lyase activity
MS6_2525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MS6_2526	COG2937	Belongs to the GPAT DAPAT family
MS6_2527	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MS6_2529	COG0534	Mate efflux family protein
MS6_2530	COG1858	cytochrome C peroxidase
MS6_2531	COG0805	protein transport
MS6_2532	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MS6_2533	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MS6_2534	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MS6_2536	COG2226	methyltransferase
MS6_2537	COG1322	Protein conserved in bacteria
MS6_2539	COG2081	HI0933 family
MS6_2541	COG1528	Iron-storage protein
MS6_2542	COG0589	response to stress
MS6_2543	COG0697	spore germination
MS6_2545	COG0742	ribosomal rna small subunit methyltransferase
MS6_2546	COG5002	protein histidine kinase activity
MS6_2546	COG5001	Diguanylate cyclase
MS6_2547	COG1522	sequence-specific DNA binding
MS6_2551	COG0006	proline dipeptidase activity
MS6_2551	COG0006	proline dipeptidase activity
MS6_2552	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MS6_2553	COG2022	thiamine diphosphate biosynthetic process
MS6_2554	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MS6_2556	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MS6_2557	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MS6_2559	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MS6_2561	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MS6_2562	COG0408	coproporphyrinogen oxidase activity
MS6_2563	COG0009	L-threonylcarbamoyladenylate synthase
MS6_2564	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MS6_2565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MS6_2566	COG0551	DNA topoisomerase type I activity
MS6_2567	COG2922	Belongs to the Smg family
MS6_2568	COG0758	DNA mediated transformation
MS6_2569	COG1652	LysM domain
MS6_2570	COG0242	peptide deformylase activity
MS6_2571	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MS6_2572	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MS6_2572	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MS6_2573	COG0569	domain protein
MS6_2574	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MS6_2576	COG1272	protein, Hemolysin III
MS6_2577	COG4326	sporulation control protein
MS6_2579	COG3084	Protein conserved in bacteria
MS6_2581	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MS6_2582	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MS6_2583	COG0204	Acyl-transferase
MS6_2584	COG0606	chelatase, subunit chli
MS6_2587	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MS6_2588	COG0129	dihydroxy-acid dehydratase activity
MS6_2590	COG0604	alcohol dehydrogenase
MS6_2592	COG0425	Belongs to the sulfur carrier protein TusA family
MS6_2594	COG2119	membrane
MS6_2595	COG0752	glycyl-tRNA synthetase alpha subunit
MS6_2596	COG0751	glycine-tRNA ligase activity
MS6_2597	COG3977	Valine--pyruvate aminotransferase
MS6_2598	COG0071	Belongs to the small heat shock protein (HSP20) family
MS6_2601	COG0187	DNA topoisomerase II activity
MS6_2602	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MS6_2603	COG0592	DNA-directed DNA polymerase activity
MS6_2604	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MS6_A0003	COG2909	trisaccharide binding
MS6_A0004	COG0058	SHG alpha-glucan phosphorylase activity
MS6_A0005	COG1640	4-alpha-glucanotransferase
MS6_A0006	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MS6_A0008	COG3501	Rhs element vgr protein
MS6_A0015	COG0471	metal ion transport
MS6_A0016	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MS6_A0024	COG0671	phosphoesterase, PA-phosphatase related
MS6_A0025	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MS6_A0027	COG1999	signal sequence binding
MS6_A0031	COG0786	glutamate:sodium symporter activity
MS6_A0035	COG1566	PFAM secretion protein HlyD family protein
MS6_A0037	COG3706	GGDEF domain
MS6_A0040	COG0813	purine-nucleoside phosphorylase activity
MS6_A0041	COG3272	Protein of unknown function (DUF1722)
MS6_A0043	COG0415	Belongs to the DNA photolyase family
MS6_A0044	COG1388	LysM domain
MS6_A0044	COG1376	ErfK ybiS ycfS ynhG family protein
MS6_A0047	COG0513	Belongs to the DEAD box helicase family
MS6_A0048	COG1770	oligopeptidase
MS6_A0054	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MS6_A0055	COG0573	inorganic phosphate transmembrane transporter activity
MS6_A0056	COG0581	inorganic phosphate transmembrane transporter activity
MS6_A0057	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MS6_A0062	COG0659	secondary active sulfate transmembrane transporter activity
MS6_A0064	COG0739	heme binding
MS6_A0065	COG5001	Diguanylate cyclase
MS6_A0065	COG3300	MHYT domain
MS6_A0066	COG0583	DNA-binding transcription factor activity
MS6_A0067	COG2814	Major facilitator Superfamily
MS6_A0072	COG1301	dicarboxylic acid transport
MS6_A0074	COG1342	Belongs to the UPF0251 family
MS6_A0081	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MS6_A0082	COG0673	inositol 2-dehydrogenase activity
MS6_A0084	COG2200	EAL domain
MS6_A0084	COG2771	luxR family
MS6_A0085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MS6_A0087	COG0564	pseudouridine synthase activity
MS6_A0105	COG3501	Rhs element vgr protein
MS6_A0109	COG1869	D-ribose catabolic process
MS6_A0110	COG1129	ABC transporter
MS6_A0111	COG1172	Belongs to the binding-protein-dependent transport system permease family
MS6_A0112	COG1879	ABC-type sugar transport system periplasmic component
MS6_A0113	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MS6_A0114	COG1609	Transcriptional regulator
MS6_A0116	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MS6_A0118	COG0584	glycerophosphoryl diester phosphodiesterase
MS6_A0119	COG2271	Major facilitator Superfamily
MS6_A0128	COG0579	oxidoreductase
MS6_A0130	COG0242	peptide deformylase activity
MS6_A0132	COG1320	monovalent cation:proton antiporter activity
MS6_A0133	COG2212	antiporter activity
MS6_A0137	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MS6_A0137	COG2111	Na H antiporter
MS6_A0139	COG0589	response to stress
MS6_A0140	COG0814	amino acid
MS6_A0141	COG3033	Beta-eliminating lyase
MS6_A0144	COG3530	Putative quorum-sensing-regulated virulence factor
MS6_A0146	COG5002	protein histidine kinase activity
MS6_A0146	COG5001	Diguanylate cyclase
MS6_A0147	COG1278	Cold shock
MS6_A0151	COG2304	oxidoreductase activity
MS6_A0155	COG0714	Associated with various cellular activities
MS6_A0156	COG0840	transmembrane signaling receptor activity
MS6_A0160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MS6_A0161	COG2195	Cleaves the N-terminal amino acid of tripeptides
MS6_A0163	COG3604	Transcriptional regulator
MS6_A0164	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MS6_A0164	COG1017	nitric oxide dioxygenase activity
MS6_A0165	COG1278	Cold shock
MS6_A0166	COG3036	rescue of stalled ribosome
MS6_A0172	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MS6_A0172	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MS6_A0173	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MS6_A0175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MS6_A0177	COG0516	GMP reductase activity
MS6_A0182	COG1943	Transposase
MS6_A0184	COG0513	Belongs to the DEAD box helicase family
MS6_A0185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MS6_A0187	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MS6_A0188	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MS6_A0189	COG3437	response regulator, receiver
MS6_A0189	COG0784	Response regulator, receiver
MS6_A0190	COG4191	Histidine kinase
MS6_A0190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MS6_A0192	COG1757	Na H antiporter
MS6_A0193	COG2814	Major facilitator Superfamily
MS6_A0196	COG3706	GGDEF domain
MS6_A0197	COG3240	lipase activity
MS6_A0199	COG0840	transmembrane signaling receptor activity
MS6_A0200	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MS6_A0201	COG5380	lipid catabolic process
MS6_A0202	COG4412	M6 family metalloprotease domain protein
MS6_A0202	COG3291	Pkd domain containing protein
MS6_A0208	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MS6_A0209	COG4605	iron ion homeostasis
MS6_A0210	COG4604	ABC transporter, ATP-binding protein
MS6_A0214	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MS6_A0218	COG0745	RESPONSE REGULATOR receiver
MS6_A0220	COG3623	hexulose-6-phosphate isomerase
MS6_A0221	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MS6_A0222	COG0561	phosphatase activity
MS6_A0228	COG3038	cytochrome b561
MS6_A0229	COG0366	Alpha amylase catalytic
MS6_A0234	COG0745	RESPONSE REGULATOR receiver
MS6_A0235	COG5002	protein histidine kinase activity
MS6_A0242	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MS6_A0245	COG2814	Major facilitator Superfamily
MS6_A0248	COG1686	Belongs to the peptidase S11 family
MS6_A0254	COG1943	Transposase
MS6_A0255	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MS6_A0255	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MS6_A0257	COG0509	glycine decarboxylation via glycine cleavage system
MS6_A0258	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MS6_A0261	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MS6_A0263	COG3039	Transposase
MS6_A0268	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MS6_A0270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MS6_A0271	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MS6_A0274	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_A0286	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MS6_A0302	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MS6_A0319	COG4977	sequence-specific DNA binding
MS6_A0323	COG1357	PFAM Pentapeptide repeats (8 copies)
MS6_A0324	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_A0332	COG1619	proteins homologs of microcin C7 resistance protein MccF
MS6_A0338	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MS6_A0342	COG3040	lipid binding
MS6_A0347	COG0456	acetyltransferase
MS6_A0365	COG0456	acetyltransferase
MS6_A0366	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MS6_A0374	COG0346	lactoylglutathione lyase activity
MS6_A0379	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MS6_A0391	COG0494	nUDIX hydrolase
MS6_A0394	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_A0396	COG3040	lipid binding
MS6_A0403	COG3041	Addiction module toxin RelE StbE family
MS6_A0413	COG1619	proteins homologs of microcin C7 resistance protein MccF
MS6_A0415	COG3549	Plasmid maintenance system killer
MS6_A0416	COG3093	addiction module antidote protein HigA
MS6_A0440	COG1619	proteins homologs of microcin C7 resistance protein MccF
MS6_A0443	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MS6_A0465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_A0479	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MS6_A0490	COG1619	proteins homologs of microcin C7 resistance protein MccF
MS6_A0495	COG3040	lipid binding
MS6_A0521	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
MS6_A0522	COG2944	sequence-specific DNA binding
MS6_A0525	COG3039	Transposase
MS6_A0526	COG0110	maltose O-acetyltransferase activity
MS6_A0529	COG0346	lactoylglutathione lyase activity
MS6_A0545	COG1943	Transposase
MS6_A0558	COG0346	lactoylglutathione lyase activity
MS6_A0563	COG1328	CTP reductase activity
MS6_A0564	COG0602	queuosine metabolic process
MS6_A0566	COG0189	ligase activity
MS6_A0566	COG4067	protein conserved in archaea
MS6_A0568	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_A0568	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MS6_A0568	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_A0569	COG1105	Belongs to the carbohydrate kinase PfkB family
MS6_A0570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_A0570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_A0571	COG1609	Transcriptional regulator
MS6_A0572	COG0420	3'-5' exonuclease activity
MS6_A0573	COG0419	ATPase involved in DNA repair
MS6_A0574	COG2205	protein histidine kinase activity
MS6_A0574	COG0784	Response regulator, receiver
MS6_A0575	COG0156	8-amino-7-oxononanoate synthase activity
MS6_A0577	COG0038	chloride channel
MS6_A0578	COG0523	cobalamin synthesis protein
MS6_A0580	COG3158	transport of potassium into the cell
MS6_A0581	COG0674	pyruvate-flavodoxin oxidoreductase activity
MS6_A0581	COG1013	pyruvate-flavodoxin oxidoreductase activity
MS6_A0581	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MS6_A0581	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MS6_A0582	COG2205	protein histidine kinase activity
MS6_A0583	COG0745	RESPONSE REGULATOR receiver
MS6_A0584	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MS6_A0585	COG0586	Pfam SNARE associated Golgi protein
MS6_A0587	COG2200	EAL domain
MS6_A0589	COG3038	cytochrome b561
MS6_A0591	COG2116	formate transmembrane transporter activity
MS6_A0592	COG0583	DNA-binding transcription factor activity
MS6_A0594	COG3593	DNA synthesis involved in DNA repair
MS6_A0595	COG0737	Belongs to the 5'-nucleotidase family
MS6_A0599	COG2824	Alkylphosphonate utilization operon protein PhnA
MS6_A0609	COG3706	GGDEF domain
MS6_A0612	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MS6_A0613	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MS6_A0615	COG0745	RESPONSE REGULATOR receiver
MS6_A0619	COG1943	Transposase
MS6_A0620	COG0023	Translation Initiation Factor
MS6_A0622	COG1181	Belongs to the D-alanine--D-alanine ligase family
MS6_A0624	COG1042	CoA-binding domain protein
MS6_A0624	COG0045	succinate-CoA ligase (ADP-forming) activity
MS6_A0624	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_A0625	COG0583	DNA-binding transcription factor activity
MS6_A0626	COG1629	transport
MS6_A0626	COG4771	TonB-dependent receptor
MS6_A0630	COG2050	protein possibly involved in aromatic compounds catabolism
MS6_A0635	COG0625	glutathione transferase activity
MS6_A0638	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MS6_A0639	COG4172	Belongs to the ABC transporter superfamily
MS6_A0640	COG4239	(ABC) transporter, permease
MS6_A0641	COG4174	ABC transporter (Permease)
MS6_A0642	COG4166	transmembrane transport
MS6_A0651	COG3842	ATPase activity
MS6_A0653	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MS6_A0655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MS6_A0656	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MS6_A0657	COG1011	Hydrolase
MS6_A0660	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MS6_A0662	COG1970	mechanosensitive ion channel activity
MS6_A0664	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MS6_A0665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_A0665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_A0666	COG0302	gtp cyclohydrolase
MS6_A0668	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MS6_A0670	COG2897	thiosulfate sulfurtransferase activity
MS6_A0671	COG2390	Transcriptional regulator
MS6_A0672	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MS6_A0673	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MS6_A0679	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MS6_A0685	COG0583	DNA-binding transcription factor activity
MS6_A0686	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MS6_A0687	COG0778	Nitroreductase
MS6_A0692	COG0640	Transcriptional regulator
MS6_A0703	COG1263	PTS System
MS6_A0703	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_A0705	COG1621	beta-fructofuranosidase activity
MS6_A0706	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MS6_A0707	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MS6_A0709	COG2885	chlorophyll binding
MS6_A0710	COG0545	Peptidyl-prolyl cis-trans isomerase
MS6_A0711	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MS6_A0712	COG0840	transmembrane signaling receptor activity
MS6_A0713	COG3069	C4-dicarboxylate transmembrane transporter activity
MS6_A0714	COG1760	l-serine dehydratase
MS6_A0719	COG1609	Transcriptional regulator
MS6_A0720	COG2197	response regulator
MS6_A0721	COG3850	Histidine kinase
MS6_A0722	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MS6_A0724	COG0243	molybdopterin cofactor binding
MS6_A0728	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MS6_A0729	COG2197	response regulator
MS6_A0730	COG3851	Histidine kinase
MS6_A0731	COG2271	Major facilitator Superfamily
MS6_A0732	COG1840	ABC-type Fe3 transport system, periplasmic component
MS6_A0734	COG3842	ATPase activity
MS6_A0735	COG3243	poly(R)-hydroxyalkanoic acid synthase
MS6_A0737	COG0183	Belongs to the thiolase family
MS6_A0739	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MS6_A0740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MS6_A0743	COG3706	GGDEF domain
MS6_A0744	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MS6_A0747	COG1979	alcohol dehydrogenase
MS6_A0750	COG4191	Histidine kinase
MS6_A0751	COG1840	ABC-type Fe3 transport system, periplasmic component
MS6_A0753	COG2271	Major facilitator Superfamily
MS6_A0754	COG0469	pyruvate kinase activity
MS6_A0755	COG2205	protein histidine kinase activity
MS6_A0755	COG2198	Histidine kinase
MS6_A0755	COG0784	Response regulator, receiver
MS6_A0756	COG1879	ABC-type sugar transport system periplasmic component
MS6_A0757	COG1803	Methylglyoxal synthase
MS6_A0758	COG1335	isochorismatase
MS6_A0760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MS6_A0763	COG0210	DNA helicase
MS6_A0764	COG1289	transmembrane transporter activity
MS6_A0770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MS6_A0771	COG4149	molybdate abc transporter
MS6_A0772	COG0725	ABC transporter, periplasmic molybdate-binding protein
MS6_A0773	COG1492	cobalamin metabolic process
MS6_A0781	COG0784	Response regulator, receiver
MS6_A0781	COG5002	protein histidine kinase activity
MS6_A0782	COG1879	ABC-type sugar transport system periplasmic component
MS6_A0784	COG2827	Endonuclease containing a URI domain
MS6_A0785	COG3132	Protein of unknown function, DUF480
MS6_A0791	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MS6_A0792	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MS6_A0794	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MS6_A0795	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
MS6_A0796	COG0247	lactate metabolic process
MS6_A0797	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MS6_A0798	COG3118	belongs to the thioredoxin family
MS6_A0802	COG0583	DNA-binding transcription factor activity
MS6_A0803	COG4160	amino acid transport
MS6_A0804	COG4215	(ABC) transporter
MS6_A0805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MS6_A0806	COG1126	abc transporter atp-binding protein
MS6_A0807	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MS6_A0809	COG0494	nUDIX hydrolase
MS6_A0810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
MS6_A0812	COG1309	transcriptional regulator
MS6_A0813	COG0513	Belongs to the DEAD box helicase family
MS6_A0814	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
MS6_A0816	COG0814	amino acid
MS6_A0817	COG0840	transmembrane signaling receptor activity
MS6_A0819	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MS6_A0820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MS6_A0822	COG1984	allophanate hydrolase subunit 2
MS6_A0826	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MS6_A0827	COG4181	ATPase activity
MS6_A0829	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MS6_A0830	COG5001	Diguanylate cyclase
MS6_A0830	COG1716	ATPase activity
MS6_A0832	COG0484	heat shock protein binding
MS6_A0841	COG0546	phosphoglycolate phosphatase activity
MS6_A0844	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MS6_A0845	COG1368	sulfuric ester hydrolase activity
MS6_A0847	COG0513	Belongs to the DEAD box helicase family
MS6_A0848	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MS6_A0850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MS6_A0852	COG3046	protein related to deoxyribodipyrimidine photolyase
MS6_A0853	COG3397	chitin binding
MS6_A0854	COG3227	Zinc metalloprotease (Elastase)
MS6_A0856	COG0010	Belongs to the arginase family
MS6_A0857	COG1166	arginine decarboxylase activity
MS6_A0860	COG2239	Acts as a magnesium transporter
MS6_A0861	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MS6_A0862	COG0459	protein refolding
MS6_A0864	COG0527	aspartate kinase activity
MS6_A0865	COG0662	Cupin 2, conserved barrel domain protein
MS6_A0866	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MS6_A0867	COG0456	acetyltransferase
MS6_A0868	COG2154	pterin-4-alpha-carbinolamine dehydratase
MS6_A0869	COG3186	Phenylalanine-4-hydroxylase
MS6_A0870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MS6_A0873	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MS6_A0874	COG0583	DNA-binding transcription factor activity
MS6_A0877	COG2171	N-acyltransferase activity
MS6_A0878	COG1253	flavin adenine dinucleotide binding
MS6_A0879	COG1765	OsmC-like protein
MS6_A0885	COG0531	amino acid
MS6_A0886	COG3706	GGDEF domain
MS6_A0888	COG3279	Response regulator of the LytR AlgR family
MS6_A0889	COG3275	phosphorelay sensor kinase activity
MS6_A0892	COG1136	(ABC) transporter
MS6_A0892	COG0577	efflux transmembrane transporter activity
MS6_A0893	COG1136	(ABC) transporter
MS6_A0897	COG4989	oxidoreductase activity
MS6_A0898	COG0366	Alpha amylase catalytic
MS6_A0900	COG2067	long-chain fatty acid transport protein
MS6_A0901	COG2267	carboxylic ester hydrolase activity
MS6_A0903	COG3227	Zinc metalloprotease (Elastase)
MS6_A0904	COG3047	cAMP biosynthetic process
MS6_A0907	COG3047	cAMP biosynthetic process
MS6_A0910	COG1686	Belongs to the peptidase S11 family
MS6_A0911	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MS6_A0913	COG1271	oxidase subunit
MS6_A0914	COG1294	oxidase, subunit
MS6_A0916	COG3048	D-serine ammonia-lyase activity
MS6_A0917	COG0583	DNA-binding transcription factor activity
MS6_A0925	COG1063	alcohol dehydrogenase
MS6_A0927	COG2873	o-acetylhomoserine
MS6_A0929	COG0346	lactoylglutathione lyase activity
MS6_A0934	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MS6_A0935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MS6_A0936	COG0363	glucosamine-6-phosphate deaminase activity
MS6_A0937	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MS6_A0942	COG1929	Belongs to the glycerate kinase type-1 family
MS6_A0943	COG2610	gluconate transmembrane transporter activity
MS6_A0944	COG3835	regulator
MS6_A0946	COG0748	coenzyme F420 binding
MS6_A0947	COG3721	Heme iron utilization protein
MS6_A0949	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MS6_A0950	COG0811	peptide transport
MS6_A0951	COG0848	biopolymer transport protein
MS6_A0952	COG4558	Periplasmic binding protein
MS6_A0953	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MS6_A0954	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MS6_A0961	COG3217	Mosc domain protein beta barrel domain protein
MS6_A0961	COG0633	Ferredoxin
MS6_A0961	COG3217	Mosc domain protein beta barrel domain protein
MS6_A0961	COG0633	Ferredoxin
MS6_A0963	COG0418	dihydroorotase activity
MS6_A0965	COG3152	Membrane
MS6_A0967	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MS6_A0968	COG2354	Protein conserved in bacteria
MS6_A0969	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MS6_A0970	COG1278	Cold shock
MS6_A0973	COG2207	Transcriptional regulator
MS6_A0973	COG4753	response regulator
MS6_A0975	COG3706	GGDEF domain
MS6_A0976	COG1349	DNA-binding transcription factor activity
MS6_A0979	COG3833	ABC-type maltose transport systems, permease component
MS6_A0980	COG1175	transmembrane transport
MS6_A0983	COG3842	ATPase activity
MS6_A0984	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_A0987	COG0393	Putative heavy-metal-binding
MS6_A0988	COG2197	response regulator
MS6_A0989	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MS6_A0990	COG0835	chemotaxis
MS6_A0990	COG0784	Response regulator, receiver
MS6_A0991	COG1846	Transcriptional regulator
MS6_A0992	COG3706	GGDEF domain
MS6_A0999	COG0583	DNA-binding transcription factor activity
MS6_A1000	COG5001	Diguanylate cyclase
MS6_A1002	COG1741	Belongs to the pirin family
MS6_A1003	COG3123	guanosine phosphorylase activity
MS6_A1005	COG2211	Major facilitator Superfamily
MS6_A1006	COG0840	transmembrane signaling receptor activity
MS6_A1007	COG1067	ATP-dependent peptidase activity
MS6_A1009	COG4172	Belongs to the ABC transporter superfamily
MS6_A1013	COG0583	DNA-binding transcription factor activity
MS6_A1015	COG1620	l-lactate permease
MS6_A1016	COG1304	FMN binding
MS6_A1018	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MS6_A1020	COG0840	transmembrane signaling receptor activity
MS6_A1022	COG0513	Belongs to the DEAD box helicase family
MS6_A1024	COG0583	DNA-binding transcription factor activity
MS6_A1026	COG1902	pentaerythritol trinitrate reductase activity
MS6_A1028	COG1132	(ABC) transporter
MS6_A1030	COG1902	pentaerythritol trinitrate reductase activity
MS6_A1032	COG1280	lysine exporter protein (LysE YggA)
MS6_A1033	COG2207	Transcriptional regulator
MS6_A1037	COG1846	Transcriptional regulator
MS6_A1038	COG1764	response to oxidative stress
MS6_A1039	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MS6_A1041	COG0697	spore germination
MS6_A1043	COG0700	Nucleoside recognition
MS6_A1044	COG3366	ferrous iron transmembrane transporter activity
MS6_A1045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MS6_A1047	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MS6_A1048	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MS6_A1049	COG2259	Doxx family
MS6_A1054	COG0363	glucosamine-6-phosphate deaminase activity
MS6_A1057	COG4580	involved in the transport of maltose and maltodextrins
MS6_A1060	COG0840	transmembrane signaling receptor activity
MS6_A1064	COG0840	transmembrane signaling receptor activity
MS6_A1066	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MS6_A1067	COG1126	abc transporter atp-binding protein
MS6_A1069	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MS6_A1070	COG4597	amino acid ABC transporter
MS6_A1071	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MS6_A1073	COG0739	heme binding
MS6_A1075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_A1075	COG2213	PTS system mannitol-specific
MS6_A1076	COG0246	Mannitol dehydrogenase
MS6_A1077	COG3722	fumarate hydratase activity
MS6_A1078	COG0673	inositol 2-dehydrogenase activity
MS6_A1084	COG2910	NAD(P)H-binding
MS6_A1086	COG0840	transmembrane signaling receptor activity
MS6_A1087	COG4221	oxidoreductase activity
MS6_A1089	COG1901	pseudouridine methyltransferase
MS6_A1090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MS6_A1092	COG0531	amino acid
MS6_A1093	COG1982	Orn Lys Arg decarboxylase major
MS6_A1101	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MS6_A1107	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MS6_A1109	COG0259	pyridoxamine-phosphate oxidase activity
MS6_A1115	COG0745	RESPONSE REGULATOR receiver
MS6_A1119	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MS6_A1120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MS6_A1121	COG0840	transmembrane signaling receptor activity
MS6_A1122	COG0835	chemotaxis
MS6_A1123	COG0835	chemotaxis
MS6_A1124	COG2198	Histidine kinase
MS6_A1124	COG0643	Histidine kinase
MS6_A1128	COG0601	transmembrane transport
MS6_A1129	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MS6_A1131	COG2194	sulfuric ester hydrolase activity
MS6_A1132	COG0642	Histidine kinase
MS6_A1133	COG0745	RESPONSE REGULATOR receiver
MS6_A1135	COG4221	oxidoreductase activity
MS6_A1139	COG1444	tRNA N-acetyltransferase activity
MS6_A1140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MS6_A1147	COG0217	transcriptional regulatory protein
MS6_A1148	COG2084	Dehydrogenase