locus-tag	class	description
N16961_VC00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N16961_VC00003	COG0592	DNA-directed DNA polymerase activity
N16961_VC00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N16961_VC00005	COG0187	DNA topoisomerase II activity
N16961_VC00008	COG0071	Belongs to the small heat shock protein (HSP20) family
N16961_VC00009	COG3977	Valine--pyruvate aminotransferase
N16961_VC00010	COG0751	glycine-tRNA ligase activity
N16961_VC00011	COG0752	glycyl-tRNA synthetase alpha subunit
N16961_VC00013	COG2119	membrane
N16961_VC00015	COG0425	Belongs to the sulfur carrier protein TusA family
N16961_VC00017	COG0604	alcohol dehydrogenase
N16961_VC00019	COG0129	dihydroxy-acid dehydratase activity
N16961_VC00020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N16961_VC00023	COG0606	chelatase, subunit chli
N16961_VC00024	COG0204	Acyl-transferase
N16961_VC00025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N16961_VC00026	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N16961_VC00028	COG3084	Protein conserved in bacteria
N16961_VC00029	COG4326	sporulation control protein
N16961_VC00030	COG1272	protein, Hemolysin III
N16961_VC00032	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N16961_VC00033	COG0569	domain protein
N16961_VC00034	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N16961_VC00034	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N16961_VC00035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N16961_VC00036	COG0242	peptide deformylase activity
N16961_VC00037	COG1652	LysM domain
N16961_VC00038	COG0758	DNA mediated transformation
N16961_VC00039	COG2922	Belongs to the Smg family
N16961_VC00040	COG0551	DNA topoisomerase type I activity
N16961_VC00041	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N16961_VC00042	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N16961_VC00043	COG0009	L-threonylcarbamoyladenylate synthase
N16961_VC00044	COG0408	coproporphyrinogen oxidase activity
N16961_VC00045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N16961_VC00047	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N16961_VC00053	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N16961_VC00055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N16961_VC00057	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N16961_VC00058	COG2104	thiamine diphosphate biosynthetic process
N16961_VC00059	COG2022	thiamine diphosphate biosynthetic process
N16961_VC00060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N16961_VC00061	COG0006	proline dipeptidase activity
N16961_VC00061	COG0006	proline dipeptidase activity
N16961_VC00065	COG1522	sequence-specific DNA binding
N16961_VC00066	COG5002	protein histidine kinase activity
N16961_VC00066	COG5001	Diguanylate cyclase
N16961_VC00067	COG0742	ribosomal rna small subunit methyltransferase
N16961_VC00069	COG0697	spore germination
N16961_VC00070	COG0589	response to stress
N16961_VC00071	COG1528	Iron-storage protein
N16961_VC00073	COG2081	HI0933 family
N16961_VC00075	COG1322	Protein conserved in bacteria
N16961_VC00076	COG2226	methyltransferase
N16961_VC00078	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N16961_VC00079	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N16961_VC00080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N16961_VC00081	COG0805	protein transport
N16961_VC00082	COG1858	cytochrome C peroxidase
N16961_VC00083	COG0534	Mate efflux family protein
N16961_VC00085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N16961_VC00086	COG2937	Belongs to the GPAT DAPAT family
N16961_VC00087	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N16961_VC00088	COG3161	chorismate lyase activity
N16961_VC00089	COG1580	Controls the rotational direction of flagella during chemotaxis
N16961_VC00090	COG0840	transmembrane signaling receptor activity
N16961_VC00092	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N16961_VC00093	COG0084	hydrolase, TatD family'
N16961_VC00097	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N16961_VC00097	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N16961_VC00099	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N16961_VC00102	COG3078	GTPase activator activity
N16961_VC00104	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N16961_VC00105	COG3071	HemY protein
N16961_VC00106	COG2959	enzyme of heme biosynthesis
N16961_VC00107	COG1587	Uroporphyrinogen-III synthase
N16961_VC00108	COG0181	hydroxymethylbilane synthase activity
N16961_VC00109	COG3072	Adenylate cyclase
N16961_VC00110	COG1965	Belongs to the frataxin family
N16961_VC00111	COG0019	diaminopimelate decarboxylase activity
N16961_VC00112	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N16961_VC00114	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N16961_VC00115	COG1011	Hydrolase
N16961_VC00116	COG2199	diguanylate cyclase activity
N16961_VC00116	COG2200	EAL domain
N16961_VC00116	COG3287	FIST C domain
N16961_VC00119	COG0561	phosphatase activity
N16961_VC00120	COG2267	carboxylic ester hydrolase activity
N16961_VC00121	COG1280	lysine exporter protein (LysE YggA)
N16961_VC00122	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N16961_VC00123	COG0783	Belongs to the Dps family
N16961_VC00128	COG0742	ribosomal rna small subunit methyltransferase
N16961_VC00129	COG0552	protein localization to endoplasmic reticulum
N16961_VC00130	COG2884	Cell division ATP-binding protein ftsE
N16961_VC00131	COG2177	Part of the ABC transporter FtsEX involved in
N16961_VC00132	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N16961_VC00133	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_VC00136	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N16961_VC00138	COG4206	TonB-dependent receptor
N16961_VC00139	COG1404	Belongs to the peptidase S8 family
N16961_VC00140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N16961_VC00152	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N16961_VC00153	COG5001	Diguanylate cyclase
N16961_VC00153	COG3300	MHYT domain
N16961_VC00155	COG3852	Histidine kinase
N16961_VC00157	COG0174	glutamine synthetase
N16961_VC00162	COG1490	D-aminoacyl-tRNA deacylase activity
N16961_VC00163	COG0456	acetyltransferase
N16961_VC00165	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N16961_VC00166	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N16961_VC00167	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N16961_VC00168	COG3031	protein transport across the cell outer membrane
N16961_VC00170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_VC00171	COG1459	type II secretion system
N16961_VC00172	COG2165	general secretion pathway protein
N16961_VC00173	COG2165	general secretion pathway protein
N16961_VC00174	COG2165	general secretion pathway protein
N16961_VC00175	COG4795	General secretion pathway protein
N16961_VC00176	COG3156	type II secretion system protein K
N16961_VC00177	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N16961_VC00178	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N16961_VC00180	COG1218	3'(2'),5'-bisphosphate nucleotidase
N16961_VC00181	COG0494	nUDIX hydrolase
N16961_VC00182	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N16961_VC00182	COG0316	Belongs to the HesB IscA family
N16961_VC00183	COG1040	competence protein
N16961_VC00184	COG0596	Alpha beta hydrolase
N16961_VC00186	COG2183	response to ionizing radiation
N16961_VC00187	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N16961_VC00188	COG0745	RESPONSE REGULATOR receiver
N16961_VC00190	COG2233	PERMEase
N16961_VC00191	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N16961_VC00193	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N16961_VC00194	COG1758	RNA polymerase activity
N16961_VC00195	COG0194	GDP metabolic process
N16961_VC00196	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N16961_VC00197	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N16961_VC00199	COG3263	regulation of cellular component size
N16961_VC00201	COG4232	protein-disulfide reductase activity
N16961_VC00204	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N16961_VC00205	COG1027	Aspartate ammonia-lyase
N16961_VC00206	COG3706	GGDEF domain
N16961_VC00207	COG3030	protein affecting phage T7 exclusion by the F plasmid
N16961_VC00208	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N16961_VC00210	COG2205	protein histidine kinase activity
N16961_VC00211	COG0745	RESPONSE REGULATOR receiver
N16961_VC00213	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N16961_VC00214	COG0205	6-phosphofructokinase activity
N16961_VC00215	COG1494	fructose-1,6-bisphosphatase
N16961_VC00216	COG3074	FtsZ-dependent cytokinesis
N16961_VC00217	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N16961_VC00218	COG0527	aspartate kinase activity
N16961_VC00218	COG0460	homoserine dehydrogenase
N16961_VC00219	COG0626	cystathionine gamma-synthase activity
N16961_VC00220	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
N16961_VC00221	COG0281	malic enzyme
N16961_VC00222	COG0254	rRNA binding
N16961_VC00223	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N16961_VC00224	COG1609	Transcriptional regulator
N16961_VC00225	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N16961_VC00226	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N16961_VC00227	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N16961_VC00228	COG1575	Belongs to the MenA family. Type 1 subfamily
N16961_VC00229	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N16961_VC00231	COG0149	triose-phosphate isomerase activity
N16961_VC00236	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N16961_VC00237	COG0459	protein refolding
N16961_VC00239	COG1509	lysine 2,3-aminomutase activity
N16961_VC00240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N16961_VC00241	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N16961_VC00242	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N16961_VC00243	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N16961_VC00244	COG1053	succinate dehydrogenase
N16961_VC00245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N16961_VC00246	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N16961_VC00247	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N16961_VC00248	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N16961_VC00249	COG1045	serine acetyltransferase
N16961_VC00251	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N16961_VC00252	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N16961_VC00253	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N16961_VC00254	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N16961_VC00255	COG0137	argininosuccinate synthase activity
N16961_VC00256	COG0165	Argininosuccinate lyase
N16961_VC00258	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_VC00259	COG0678	peroxiredoxin activity
N16961_VC00259	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N16961_VC00261	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N16961_VC00267	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N16961_VC00268	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N16961_VC00270	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N16961_VC00271	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N16961_VC00272	COG0546	phosphoglycolate phosphatase activity
N16961_VC00273	COG0180	Tryptophanyl-tRNA synthetase
N16961_VC00276	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N16961_VC00278	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N16961_VC00280	COG1012	belongs to the aldehyde dehydrogenase family
N16961_VC00282	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N16961_VC00283	COG3954	Phosphoribulokinase
N16961_VC00285	COG0429	hydrolase of the alpha beta-hydrolase fold
N16961_VC00287	COG0488	(ABC) transporter
N16961_VC00288	COG2249	NAD(P)H dehydrogenase (quinone) activity
N16961_VC00291	COG1047	Peptidyl-prolyl cis-trans
N16961_VC00293	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N16961_VC00294	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N16961_VC00295	COG3083	sulfuric ester hydrolase activity
N16961_VC00296	COG0557	exoribonuclease II activity
N16961_VC00297	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N16961_VC00298	COG0051	transcription antitermination factor activity, RNA binding
N16961_VC00299	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N16961_VC00300	COG0088	Forms part of the polypeptide exit tunnel
N16961_VC00301	COG0089	rRNA binding
N16961_VC00302	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N16961_VC00303	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N16961_VC00304	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N16961_VC00305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N16961_VC00306	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N16961_VC00307	COG0255	Belongs to the universal ribosomal protein uL29 family
N16961_VC00308	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N16961_VC00309	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N16961_VC00310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N16961_VC00311	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N16961_VC00312	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N16961_VC00313	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N16961_VC00314	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N16961_VC00315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N16961_VC00316	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N16961_VC00317	COG1841	ribosomal large subunit assembly
N16961_VC00318	COG0200	Binds to the 23S rRNA
N16961_VC00319	COG0201	protein transport
N16961_VC00322	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N16961_VC00323	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N16961_VC00324	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N16961_VC00325	COG0202	RNA polymerase activity
N16961_VC00326	COG0203	ribosomal protein L17
N16961_VC00328	COG0545	Peptidyl-prolyl cis-trans isomerase
N16961_VC00329	COG3061	Opacity-associated protein A
N16961_VC00329	COG3266	domain, Protein
N16961_VC00330	COG0697	spore germination
N16961_VC00331	COG2153	protein acetylation
N16961_VC00332	COG0513	Belongs to the DEAD box helicase family
N16961_VC00334	COG0737	Belongs to the 5'-nucleotidase family
N16961_VC00335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N16961_VC00335	COG1648	precorrin-2 dehydrogenase activity
N16961_VC00336	COG0175	sulfate reduction
N16961_VC00337	COG2895	sulfate adenylyltransferase (ATP) activity
N16961_VC00338	COG0529	Catalyzes the synthesis of activated sulfate
N16961_VC00342	COG1136	(ABC) transporter
N16961_VC00345	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N16961_VC00346	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_VC00347	COG0729	surface antigen
N16961_VC00349	COG2105	PFAM AIG2 family protein
N16961_VC00350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N16961_VC00351	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N16961_VC00352	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N16961_VC00353	COG0163	prenyltransferase activity
N16961_VC00354	COG4143	(ABC) transporter
N16961_VC00355	COG1178	ABC-type Fe3 transport system permease component
N16961_VC00356	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N16961_VC00357	COG3028	Belongs to the UPF0307 family
N16961_VC00358	COG0312	modulator of DNA gyrase
N16961_VC00359	COG2239	Acts as a magnesium transporter
N16961_VC00360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_VC00361	COG1660	Displays ATPase and GTPase activities
N16961_VC00362	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_VC00363	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N16961_VC00365	COG1137	ATPase activity
N16961_VC00366	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N16961_VC00369	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N16961_VC00369	COG0517	IMP dehydrogenase activity
N16961_VC00371	COG1127	ABC transporter
N16961_VC00372	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N16961_VC00373	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N16961_VC00374	COG2854	intermembrane phospholipid transfer
N16961_VC00376	COG5007	Belongs to the BolA IbaG family
N16961_VC00377	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N16961_VC00378	COG0204	Acyl-transferase
N16961_VC00379	COG0251	oxidation-reduction process
N16961_VC00380	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
N16961_VC00381	COG0540	Belongs to the ATCase OTCase family
N16961_VC00382	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N16961_VC00383	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N16961_VC00384	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N16961_VC00385	COG0564	pseudouridine synthase activity
N16961_VC00386	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N16961_VC00387	COG0525	valine-tRNA ligase activity
N16961_VC00388	COG2927	DNA polymerase III (CHI subunit)
N16961_VC00389	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N16961_VC00390	COG0795	lipopolysaccharide-transporting ATPase activity
N16961_VC00391	COG0795	lipopolysaccharide-transporting ATPase activity
N16961_VC00394	COG3437	response regulator, receiver
N16961_VC00402	COG0066	3-isopropylmalate dehydratase activity
N16961_VC00403	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N16961_VC00404	COG0473	3-isopropylmalate dehydrogenase activity
N16961_VC00405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N16961_VC00409	COG0583	DNA-binding transcription factor activity
N16961_VC00410	COG1022	Amp-dependent synthetase and ligase
N16961_VC00411	COG0028	Belongs to the TPP enzyme family
N16961_VC00412	COG0440	acetolactate synthase activity
N16961_VC00413	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N16961_VC00414	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N16961_VC00415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N16961_VC00417	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N16961_VC00419	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_VC00420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_VC00422	COG0354	folic acid binding
N16961_VC00423	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N16961_VC00425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N16961_VC00426	COG1595	DNA-templated transcription, initiation
N16961_VC00428	COG3026	antisigma factor binding
N16961_VC00429	COG3086	response to oxidative stress
N16961_VC00430	COG0481	GTPase activity
N16961_VC00431	COG0681	Belongs to the peptidase S26 family
N16961_VC00432	COG0571	ribonuclease III activity
N16961_VC00433	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N16961_VC00434	COG1381	Involved in DNA repair and RecF pathway recombination
N16961_VC00435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N16961_VC00436	COG0736	holo-[acyl-carrier-protein] synthase activity
N16961_VC00439	COG5001	Diguanylate cyclase
N16961_VC00441	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N16961_VC00442	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N16961_VC00443	COG3956	TIGRFAM MazG family protein
N16961_VC00444	COG0504	CTP synthase activity
N16961_VC00445	COG0148	phosphopyruvate hydratase activity
N16961_VC00446	COG0617	tRNA 3'-terminal CCA addition
N16961_VC00447	COG3409	Peptidoglycan-binding domain 1 protein
N16961_VC00447	COG3267	Type II secretory pathway component ExeA
N16961_VC00449	COG4991	sh3 domain protein
N16961_VC00450	COG0306	phosphate transporter
N16961_VC00451	COG1392	Phosphate transport regulator
N16961_VC00452	COG3025	triphosphatase activity
N16961_VC00454	COG0840	transmembrane signaling receptor activity
N16961_VC00455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N16961_VC00457	COG1538	Outer membrane efflux protein
N16961_VC00458	COG0494	nUDIX hydrolase
N16961_VC00459	COG3151	Protein conserved in bacteria
N16961_VC00461	COG3150	esterase
N16961_VC00462	COG0187	DNA topoisomerase II activity
N16961_VC00463	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N16961_VC00464	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N16961_VC00465	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
N16961_VC00466	COG0237	dephospho-CoA kinase activity
N16961_VC00468	COG1459	type II secretion system
N16961_VC00469	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_VC00473	COG0716	FMN binding
N16961_VC00474	COG4974	Belongs to the 'phage' integrase family
N16961_VC00475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N16961_VC00476	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N16961_VC00477	COG0737	Belongs to the 5'-nucleotidase family
N16961_VC00478	COG2186	Transcriptional regulator
N16961_VC00479	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N16961_VC00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
N16961_VC00481	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_VC00485	COG0275	rRNA processing
N16961_VC00486	COG3116	cell division
N16961_VC00487	COG0768	penicillin binding
N16961_VC00488	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N16961_VC00489	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N16961_VC00490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N16961_VC00491	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N16961_VC00492	COG0772	Belongs to the SEDS family
N16961_VC00493	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N16961_VC00494	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N16961_VC00495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N16961_VC00496	COG0849	cell division
N16961_VC00497	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N16961_VC00498	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N16961_VC00500	COG0653	protein targeting
N16961_VC00501	COG0494	nUDIX hydrolase
N16961_VC00502	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N16961_VC00503	COG0505	Belongs to the CarA family
N16961_VC00504	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N16961_VC00508	COG4172	Belongs to the ABC transporter superfamily
N16961_VC00512	COG0730	response to heat
N16961_VC00513	COG0583	DNA-binding transcription factor activity
N16961_VC00514	COG2860	membrane
N16961_VC00515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N16961_VC00517	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N16961_VC00519	COG0493	'glutamate synthase
N16961_VC00520	COG0070	glutamate synthase
N16961_VC00520	COG0069	glutamate synthase activity
N16961_VC00520	COG0067	glutamate synthase
N16961_VC00522	COG0067	glutamate synthase
N16961_VC00522	COG0070	glutamate synthase
N16961_VC00522	COG0069	glutamate synthase activity
N16961_VC00523	COG1242	4 iron, 4 sulfur cluster binding
N16961_VC00524	COG3706	GGDEF domain
N16961_VC00524	COG4251	negative regulation of phosphorylation
N16961_VC00524	COG5001	Diguanylate cyclase
N16961_VC00524	COG2203	Gaf domain
N16961_VC00525	COG0784	Response regulator, receiver
N16961_VC00525	COG2198	Histidine kinase
N16961_VC00525	COG5002	protein histidine kinase activity
N16961_VC00526	COG0745	RESPONSE REGULATOR receiver
N16961_VC00528	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N16961_VC00532	COG0083	homoserine kinase activity
N16961_VC00533	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N16961_VC00534	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
N16961_VC00535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N16961_VC00536	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N16961_VC00539	COG1115	amino acid carrier protein
N16961_VC00542	COG0084	hydrolase, TatD family'
N16961_VC00543	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N16961_VC00544	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N16961_VC00545	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N16961_VC00546	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N16961_VC00547	COG0813	purine-nucleoside phosphorylase activity
N16961_VC00549	COG0560	Phosphoserine phosphatase
N16961_VC00551	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N16961_VC00552	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N16961_VC00553	COG1022	Amp-dependent synthetase and ligase
N16961_VC00556	COG3250	beta-galactosidase activity
N16961_VC00557	COG1609	Transcriptional regulator
N16961_VC00558	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_VC00561	COG0569	domain protein
N16961_VC00561	COG0189	ligase activity
N16961_VC00563	COG0456	acetyltransferase
N16961_VC00565	COG2171	N-acyltransferase activity
N16961_VC00566	COG3141	response to X-ray
N16961_VC00569	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N16961_VC00570	COG1074	ATP-dependent DNA helicase activity
N16961_VC00571	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N16961_VC00573	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N16961_VC00573	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N16961_VC00575	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N16961_VC00576	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N16961_VC00577	COG2166	iron-sulfur cluster assembly
N16961_VC00578	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N16961_VC00579	COG0693	protein deglycase activity
N16961_VC00580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N16961_VC00581	COG3248	Nucleoside-binding outer membrane protein
N16961_VC00583	COG1595	DNA-templated transcription, initiation
N16961_VC00585	COG2211	Major facilitator Superfamily
N16961_VC00586	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N16961_VC00588	COG2813	Specifically methylates the guanine in position
N16961_VC00589	COG0271	Belongs to the BolA IbaG family
N16961_VC00590	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_VC00591	COG1805	sodium ion transport
N16961_VC00592	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_VC00593	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_VC00594	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_VC00595	COG2871	sodium ion transport
N16961_VC00596	COG1477	protein flavinylation
N16961_VC00598	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N16961_VC00600	COG3706	GGDEF domain
N16961_VC00601	COG0733	neurotransmitter:sodium symporter activity
N16961_VC00603	COG0189	ligase activity
N16961_VC00604	COG4067	protein conserved in archaea
N16961_VC00604	COG0189	ligase activity
N16961_VC00605	COG2195	Cleaves the N-terminal amino acid of tripeptides
N16961_VC00606	COG2252	PERMEase
N16961_VC00607	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N16961_VC00610	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N16961_VC00611	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N16961_VC00612	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N16961_VC00613	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N16961_VC00613	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N16961_VC00616	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N16961_VC00617	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N16961_VC00618	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N16961_VC00619	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N16961_VC00621	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N16961_VC00622	COG0024	Methionine aminopeptidase
N16961_VC00624	COG0052	Belongs to the universal ribosomal protein uS2 family
N16961_VC00625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N16961_VC00626	COG0528	UMP kinase activity
N16961_VC00627	COG0233	cytoplasmic translational termination
N16961_VC00628	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N16961_VC00629	COG0575	Belongs to the CDS family
N16961_VC00630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N16961_VC00631	COG0750	zinc metalloprotease
N16961_VC00633	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N16961_VC00634	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_VC00635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N16961_VC00636	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_VC00637	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_VC00638	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N16961_VC00639	COG0587	DNA-directed DNA polymerase activity
N16961_VC00640	COG0825	malonyl-CoA metabolic process
N16961_VC00641	COG0037	tRNA processing
N16961_VC00643	COG3479	Phenolic acid decarboxylase
N16961_VC00644	COG0347	Belongs to the P(II) protein family
N16961_VC00646	COG0741	lytic transglycosylase activity
N16961_VC00646	COG1388	LysM domain
N16961_VC00647	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N16961_VC00648	COG2226	methyltransferase
N16961_VC00649	COG0328	RNA-DNA hybrid ribonuclease activity
N16961_VC00650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N16961_VC00652	COG1960	acyl-CoA dehydrogenase activity
N16961_VC00653	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N16961_VC00654	COG0121	glutamine amidotransferase
N16961_VC00655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N16961_VC00656	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N16961_VC00657	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N16961_VC00659	COG3706	GGDEF domain
N16961_VC00660	COG1187	pseudouridine synthase activity
N16961_VC00661	COG2840	Smr protein MutS2
N16961_VC00664	COG3735	TraB family
N16961_VC00667	COG2608	mercury ion transmembrane transporter activity
N16961_VC00667	COG2217	Heavy metal translocating P-type atpase
N16961_VC00668	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N16961_VC00671	COG4774	siderophore transport
N16961_VC00671	COG1629	transport
N16961_VC00672	COG2375	cellular response to nickel ion
N16961_VC00673	COG3433	isochorismatase activity
N16961_VC00673	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N16961_VC00673	COG2226	methyltransferase
N16961_VC00680	COG0784	Response regulator, receiver
N16961_VC00680	COG0835	chemotaxis
N16961_VC00681	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N16961_VC00682	COG1815	bacterial-type flagellum-dependent cell motility
N16961_VC00683	COG1558	bacterial-type flagellum-dependent cell motility
N16961_VC00684	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N16961_VC00685	COG1749	Flagellar hook protein flgE
N16961_VC00686	COG4787	bacterial-type flagellum-dependent cell motility
N16961_VC00687	COG4786	Flagellar basal body rod
N16961_VC00688	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N16961_VC00689	COG1706	bacterial-type flagellum-dependent cell motility
N16961_VC00690	COG1705	Flagellar rod assembly protein muramidase FlgJ
N16961_VC00690	COG3951	Flagellar rod assembly protein muramidase FlgJ
N16961_VC00693	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_VC00694	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_VC00711	COG0012	GTP binding
N16961_VC00712	COG0193	aminoacyl-tRNA hydrolase activity
N16961_VC00713	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N16961_VC00714	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N16961_VC00715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N16961_VC00716	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N16961_VC00717	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N16961_VC00718	COG2890	protein-(glutamine-N5) methyltransferase activity
N16961_VC00719	COG3094	Invasion gene expression up-regulator, SirB
N16961_VC00720	COG2912	Transglutaminase-like superfamily
N16961_VC00721	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N16961_VC00722	COG0737	Belongs to the 5'-nucleotidase family
N16961_VC00723	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N16961_VC00724	COG2233	PERMEase
N16961_VC00728	COG1393	Belongs to the ArsC family
N16961_VC00729	COG4783	chaperone-mediated protein folding
N16961_VC00733	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N16961_VC00735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N16961_VC00736	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
N16961_VC00738	COG1876	peptidase activity
N16961_VC00739	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N16961_VC00740	COG1393	Belongs to the ArsC family
N16961_VC00744	COG2837	iron assimilation
N16961_VC00745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_VC00746	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_VC00747	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_VC00748	COG1334	flagellar protein FlaG
N16961_VC00749	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N16961_VC00751	COG1516	flagellar protein fliS
N16961_VC00752	COG2204	response regulator
N16961_VC00753	COG4191	Histidine kinase
N16961_VC00754	COG2204	response regulator
N16961_VC00755	COG1677	Flagellar hook-basal body complex protein FliE
N16961_VC00757	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N16961_VC00758	COG1317	bacterial-type flagellum organization
N16961_VC00762	COG1580	Controls the rotational direction of flagella during chemotaxis
N16961_VC00767	COG1987	bacterial-type flagellum assembly
N16961_VC00768	COG1684	flagellar biosynthetic protein fliR
N16961_VC00771	COG2890	protein-(glutamine-N5) methyltransferase activity
N16961_VC00772	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N16961_VC00773	COG2860	membrane
N16961_VC00774	COG3101	peptidyl-lysine hydroxylation
N16961_VC00776	COG0431	NADPH-dependent FMN reductase
N16961_VC00777	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N16961_VC00777	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N16961_VC00778	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N16961_VC00779	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N16961_VC00780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N16961_VC00781	COG0735	belongs to the Fur family
N16961_VC00783	COG0583	DNA-binding transcription factor activity
N16961_VC00785	COG1346	cytolysis
N16961_VC00788	COG0596	Alpha beta hydrolase
N16961_VC00789	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N16961_VC00790	COG0033	Phosphoglucomutase
N16961_VC00792	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N16961_VC00793	COG0372	Belongs to the citrate synthase family
N16961_VC00794	COG2009	succinate dehydrogenase
N16961_VC00795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N16961_VC00796	COG1053	succinate dehydrogenase
N16961_VC00798	COG0567	Dehydrogenase, E1 component
N16961_VC00799	COG0508	dehydrogenase complex catalyzes the overall conversion of
N16961_VC00800	COG0045	succinate-CoA ligase (ADP-forming) activity
N16961_VC00802	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N16961_VC00803	COG1121	(ABC) transporter
N16961_VC00804	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N16961_VC00805	COG4977	sequence-specific DNA binding
N16961_VC00807	COG1918	ferrous iron import across plasma membrane
N16961_VC00811	COG0018	arginyl-trna synthetase
N16961_VC00813	COG1025	Belongs to the peptidase M16 family
N16961_VC00814	COG2062	phosphohistidine phosphatase, SixA
N16961_VC00817	COG0455	bacterial-type flagellum organization
N16961_VC00820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N16961_VC00821	COG2198	Histidine kinase
N16961_VC00821	COG0643	Histidine kinase
N16961_VC00822	COG2201	protein-glutamate methylesterase activity
N16961_VC00823	COG1192	Involved in chromosome partitioning
N16961_VC00825	COG0835	chemotaxis
N16961_VC00827	COG4133	protoheme IX ABC transporter activity
N16961_VC00828	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N16961_VC00829	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N16961_VC00831	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N16961_VC00832	COG1138	Cytochrome C-type biogenesis protein
N16961_VC00833	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N16961_VC00834	COG3088	subunit of a heme lyase
N16961_VC00834	COG4235	cytochrome complex assembly
N16961_VC00836	COG2853	Lipoprotein
N16961_VC00840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N16961_VC00841	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N16961_VC00842	COG0123	including yeast histone deacetylase and acetoin utilization protein
N16961_VC00845	COG3083	sulfuric ester hydrolase activity
N16961_VC00847	COG3081	Nucleoid-associated protein
N16961_VC00849	COG1757	Na H antiporter
N16961_VC00850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N16961_VC00851	COG2095	MarC family integral membrane protein
N16961_VC00852	COG1012	belongs to the aldehyde dehydrogenase family
N16961_VC00852	COG1454	alcohol dehydrogenase
N16961_VC00854	COG0659	secondary active sulfate transmembrane transporter activity
N16961_VC00855	COG1530	ribonuclease E activity
N16961_VC00856	COG0564	pseudouridine synthase activity
N16961_VC00857	COG0424	maF-like protein
N16961_VC00858	COG1399	metal-binding, possibly nucleic acid-binding protein
N16961_VC00859	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N16961_VC00860	COG0416	fatty acid biosynthetic process
N16961_VC00861	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N16961_VC00862	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N16961_VC00863	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_VC00864	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N16961_VC00865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N16961_VC00866	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N16961_VC00867	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N16961_VC00868	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N16961_VC00870	COG0084	hydrolase, TatD family'
N16961_VC00871	COG1263	PTS System
N16961_VC00871	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_VC00873	COG0733	neurotransmitter:sodium symporter activity
N16961_VC00876	COG4667	esterase of the alpha-beta hydrolase superfamily
N16961_VC00878	COG1940	carbohydrate kinase activity
N16961_VC00879	COG0784	Response regulator, receiver
N16961_VC00879	COG0835	chemotaxis
N16961_VC00882	COG2226	methyltransferase
N16961_VC00884	COG0676	glucose-6-phosphate 1-epimerase activity
N16961_VC00885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N16961_VC00886	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_VC00888	COG3139	Protein of unknown function (DUF1315)
N16961_VC00889	COG0252	asparaginase activity
N16961_VC00890	COG0616	signal peptide processing
N16961_VC00891	COG1902	pentaerythritol trinitrate reductase activity
N16961_VC00891	COG0446	pyridine nucleotide-disulphide oxidoreductase
N16961_VC00892	COG0788	formyltetrahydrofolate deformylase activity
N16961_VC00894	COG1199	ATP-dependent helicase activity
N16961_VC00895	COG1214	PFAM Peptidase M22, glycoprotease
N16961_VC00898	COG0596	Alpha beta hydrolase
N16961_VC00899	COG0318	PFAM AMP-dependent synthetase and ligase
N16961_VC00900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N16961_VC00904	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N16961_VC00905	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N16961_VC00906	COG0436	Aminotransferase
N16961_VC00907	COG1169	isochorismate synthase
N16961_VC00908	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N16961_VC00909	COG0596	Alpha beta hydrolase
N16961_VC00911	COG1441	menaquinone biosynthetic process
N16961_VC00913	COG3135	benzoate transporter
N16961_VC00914	COG1396	sequence-specific DNA binding
N16961_VC00915	COG0840	transmembrane signaling receptor activity
N16961_VC00916	COG0477	Major facilitator Superfamily
N16961_VC00921	COG3015	lipoprotein NlpE involved in copper resistance
N16961_VC00922	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N16961_VC00923	COG2894	cell division
N16961_VC00924	COG0850	regulation of cytokinetic process
N16961_VC00925	COG3100	YcgL domain-containing protein
N16961_VC00926	COG2951	lytic endotransglycosylase activity
N16961_VC00928	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N16961_VC00929	COG3469	chitinase activity
N16961_VC00929	COG3325	Belongs to the glycosyl hydrolase 18 family
N16961_VC00930	COG3005	denitrification pathway
N16961_VC00931	COG0243	molybdopterin cofactor binding
N16961_VC00935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_VC00937	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N16961_VC00944	COG4589	Belongs to the CDS family
N16961_VC00946	COG5001	Diguanylate cyclase
N16961_VC00946	COG3300	MHYT domain
N16961_VC00949	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N16961_VC00950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N16961_VC00951	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N16961_VC00952	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N16961_VC00954	COG4191	Histidine kinase
N16961_VC00955	COG0544	peptidyl-prolyl cis-trans isomerase activity
N16961_VC00957	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N16961_VC00958	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N16961_VC00959	COG0776	regulation of translation
N16961_VC00961	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N16961_VC00962	COG1555	photosystem II stabilization
N16961_VC00963	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N16961_VC00964	COG0539	negative regulation of cytoplasmic translation
N16961_VC00965	COG0776	regulation of translation
N16961_VC00966	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N16961_VC00967	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N16961_VC00968	COG0284	orotidine-5'-phosphate decarboxylase activity
N16961_VC00971	COG0583	DNA-binding transcription factor activity
N16961_VC00973	COG0686	Belongs to the AlaDH PNT family
N16961_VC00975	COG1674	ftsk spoiiie
N16961_VC00976	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N16961_VC00977	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N16961_VC00978	COG2186	Transcriptional regulator
N16961_VC00981	COG0537	adenosine 5'-monophosphoramidase activity
N16961_VC00987	COG1252	NADH dehydrogenase
N16961_VC00991	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N16961_VC00993	COG4591	ABC-type transport system involved in lipoprotein release permease component
N16961_VC00994	COG1136	(ABC) transporter
N16961_VC00995	COG4591	ABC-type transport system involved in lipoprotein release permease component
N16961_VC00997	COG0658	competence protein
N16961_VC00997	COG2333	competence protein COMEC
N16961_VC00998	COG1132	(ABC) transporter
N16961_VC00999	COG1663	tetraacyldisaccharide 4'-kinase activity
N16961_VC01001	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N16961_VC01002	COG2719	SpoVR family
N16961_VC01003	COG2718	Belongs to the UPF0229 family
N16961_VC01004	COG2766	serine protein kinase
N16961_VC01005	COG3013	Belongs to the UPF0304 family
N16961_VC01007	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N16961_VC01008	COG0840	transmembrane signaling receptor activity
N16961_VC01010	COG1882	Formate acetyltransferase
N16961_VC01015	COG4215	(ABC) transporter
N16961_VC01016	COG4160	amino acid transport
N16961_VC01017	COG0708	Exodeoxyribonuclease III
N16961_VC01018	COG0840	transmembrane signaling receptor activity
N16961_VC01020	COG3923	Primosomal replication protein n
N16961_VC01021	COG0730	response to heat
N16961_VC01022	COG1199	ATP-dependent helicase activity
N16961_VC01023	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N16961_VC01024	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N16961_VC01026	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N16961_VC01027	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_VC01028	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N16961_VC01029	COG0215	cysteine-tRNA ligase activity
N16961_VC01030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N16961_VC01031	COG0632	four-way junction helicase activity
N16961_VC01032	COG2255	four-way junction helicase activity
N16961_VC01034	COG1271	oxidase subunit
N16961_VC01035	COG1294	oxidase, subunit
N16961_VC01036	COG4890	Cyd operon protein YbgT
N16961_VC01037	COG0824	Thioesterase
N16961_VC01038	COG0811	peptide transport
N16961_VC01041	COG0823	Involved in the tonB-independent uptake of proteins
N16961_VC01042	COG2885	chlorophyll binding
N16961_VC01044	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N16961_VC01046	COG5002	protein histidine kinase activity
N16961_VC01046	COG0784	Response regulator, receiver
N16961_VC01048	COG1482	cell wall glycoprotein biosynthetic process
N16961_VC01049	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_VC01049	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_VC01049	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_VC01050	COG2207	Transcriptional regulator
N16961_VC01052	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_VC01053	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_VC01054	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_VC01056	COG1012	belongs to the aldehyde dehydrogenase family
N16961_VC01057	COG3284	Transcriptional regulator
N16961_VC01058	COG4628	conserved protein (DUF2132)
N16961_VC01060	COG0415	Belongs to the DNA photolyase family
N16961_VC01075	COG0488	(ABC) transporter
N16961_VC01083	COG3941	tape measure
N16961_VC01088	COG2003	Belongs to the UPF0758 family
N16961_VC01090	COG4409	exo-alpha-(2->6)-sialidase activity
N16961_VC01091	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N16961_VC01092	COG1940	carbohydrate kinase activity
N16961_VC01093	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N16961_VC01094	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N16961_VC01095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N16961_VC01096	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N16961_VC01097	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N16961_VC01098	COG1737	Transcriptional regulator
N16961_VC01099	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
N16961_VC01100	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
N16961_VC01104	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N16961_VC01108	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N16961_VC01112	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N16961_VC01113	COG0582	viral genome integration into host DNA
N16961_VC01114	COG0582	viral genome integration into host DNA
N16961_VC01117	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_VC01119	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N16961_VC01119	COG3008	intermembrane lipid transfer
N16961_VC01120	COG2995	paraquat-inducible protein a
N16961_VC01121	COG0668	transmembrane transport
N16961_VC01125	COG1309	transcriptional regulator
N16961_VC01126	COG1012	belongs to the aldehyde dehydrogenase family
N16961_VC01132	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N16961_VC01133	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N16961_VC01134	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N16961_VC01135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N16961_VC01136	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N16961_VC01138	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N16961_VC01139	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N16961_VC01140	COG0297	glycogen (starch) synthase activity
N16961_VC01144	COG3070	regulator of competence-specific genes
N16961_VC01146	COG1609	Transcriptional regulator
N16961_VC01147	COG3381	protein complex oligomerization
N16961_VC01148	COG0745	RESPONSE REGULATOR receiver
N16961_VC01149	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N16961_VC01150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N16961_VC01151	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
N16961_VC01152	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N16961_VC01153	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N16961_VC01156	COG1032	radical SAM domain protein
N16961_VC01158	COG0612	Peptidase, M16
N16961_VC01161	COG0583	DNA-binding transcription factor activity
N16961_VC01162	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N16961_VC01164	COG2350	Protein conserved in bacteria
N16961_VC01165	COG1607	acyl-coa hydrolase
N16961_VC01166	COG2917	probably involved in intracellular septation
N16961_VC01168	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N16961_VC01169	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N16961_VC01171	COG2116	formate transmembrane transporter activity
N16961_VC01172	COG4459	periplasmic nitrate reductase
N16961_VC01173	COG3005	denitrification pathway
N16961_VC01174	COG0243	molybdopterin cofactor binding
N16961_VC01178	COG1227	inorganic diphosphatase activity
N16961_VC01181	COG4172	Belongs to the ABC transporter superfamily
N16961_VC01183	COG4171	peptide transport system, permease
N16961_VC01184	COG4168	peptide transport system, permease
N16961_VC01186	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N16961_VC01187	COG1842	Phage shock protein A
N16961_VC01190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_VC01193	COG2818	Glycosylase
N16961_VC01194	COG0626	cystathionine gamma-synthase activity
N16961_VC01196	COG0733	neurotransmitter:sodium symporter activity
N16961_VC01197	COG0564	pseudouridine synthase activity
N16961_VC01198	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N16961_VC01199	COG4136	ATPase activity
N16961_VC01200	COG4135	transport system, permease component
N16961_VC01201	COG4134	Bacterial extracellular solute-binding protein
N16961_VC01203	COG3313	Fe-S protein
N16961_VC01205	COG0842	Transport permease protein
N16961_VC01206	COG1131	(ABC) transporter
N16961_VC01207	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_VC01208	COG0814	amino acid
N16961_VC01211	COG2239	Acts as a magnesium transporter
N16961_VC01216	COG4934	collagen metabolic process
N16961_VC01222	COG0840	transmembrane signaling receptor activity
N16961_VC01224	COG4251	negative regulation of phosphorylation
N16961_VC01224	COG5001	Diguanylate cyclase
N16961_VC01224	COG3706	GGDEF domain
N16961_VC01224	COG2203	Gaf domain
N16961_VC01225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N16961_VC01229	COG1061	Type III restriction enzyme res subunit
N16961_VC01230	COG1187	pseudouridine synthase activity
N16961_VC01231	COG2814	Major facilitator Superfamily
N16961_VC01233	COG0702	epimerase
N16961_VC01234	COG0534	Mate efflux family protein
N16961_VC01235	COG4181	ATPase activity
N16961_VC01238	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N16961_VC01240	COG1748	Saccharopine dehydrogenase
N16961_VC01241	COG0019	diaminopimelate decarboxylase activity
N16961_VC01243	COG1538	Outer membrane efflux protein
N16961_VC01247	COG0583	DNA-binding transcription factor activity
N16961_VC01249	COG1451	nucleotide metabolic process
N16961_VC01250	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
N16961_VC01252	COG3063	Type IV pilus biogenesis stability protein PilW
N16961_VC01253	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N16961_VC01257	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_VC01260	COG3290	protein histidine kinase activity
N16961_VC01261	COG4565	transcriptional regulatory protein
N16961_VC01263	COG0784	Response regulator, receiver
N16961_VC01263	COG0835	chemotaxis
N16961_VC01266	COG0745	RESPONSE REGULATOR receiver
N16961_VC01266	COG3706	GGDEF domain
N16961_VC01271	COG1085	galactose-1-phosphate uridylyltransferase
N16961_VC01272	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N16961_VC01273	COG2017	converts alpha-aldose to the beta-anomer
N16961_VC01274	COG3706	GGDEF domain
N16961_VC01275	COG2199	diguanylate cyclase activity
N16961_VC01275	COG2200	EAL domain
N16961_VC01278	COG3527	Alpha-acetolactate decarboxylase
N16961_VC01281	COG0753	catalase activity
N16961_VC01285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N16961_VC01287	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N16961_VC01295	COG1271	oxidase subunit
N16961_VC01296	COG1294	oxidase, subunit
N16961_VC01297	COG1136	(ABC) transporter
N16961_VC01297	COG4591	ABC-type transport system involved in lipoprotein release permease component
N16961_VC01298	COG0577	efflux transmembrane transporter activity
N16961_VC01298	COG1136	(ABC) transporter
N16961_VC01299	COG1136	(ABC) transporter
N16961_VC01299	COG0577	efflux transmembrane transporter activity
N16961_VC01303	COG0583	DNA-binding transcription factor activity
N16961_VC01304	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N16961_VC01305	COG2723	6-phospho-beta-galactosidase activity
N16961_VC01306	COG1609	Transcriptional regulator
N16961_VC01307	COG0251	oxidation-reduction process
N16961_VC01308	COG2731	YhcH YjgK YiaL family protein
N16961_VC01309	COG0584	glycerophosphoryl diester phosphodiesterase
N16961_VC01310	COG1349	DNA-binding transcription factor activity
N16961_VC01311	COG3842	ATPase activity
N16961_VC01312	COG0395	ABC-type sugar transport system, permease component
N16961_VC01313	COG1175	transmembrane transport
N16961_VC01316	COG0811	peptide transport
N16961_VC01317	COG0811	peptide transport
N16961_VC01318	COG0848	biopolymer transport protein
N16961_VC01319	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N16961_VC01321	COG1793	dna ligase
N16961_VC01323	COG0534	Mate efflux family protein
N16961_VC01327	COG0791	NLP P60 protein
N16961_VC01328	COG0840	transmembrane signaling receptor activity
N16961_VC01331	COG1940	carbohydrate kinase activity
N16961_VC01336	COG0746	molybdenum cofactor guanylyltransferase activity
N16961_VC01337	COG3842	ATPase activity
N16961_VC01338	COG4662	Binding-protein-dependent transport system inner membrane component
N16961_VC01340	COG2204	response regulator
N16961_VC01341	COG3852	Histidine kinase
N16961_VC01342	COG0488	(ABC) transporter
N16961_VC01343	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N16961_VC01349	COG3383	formate dehydrogenase (NAD+) activity
N16961_VC01349	COG0243	molybdopterin cofactor binding
N16961_VC01350	COG0437	4 iron, 4 sulfur cluster binding
N16961_VC01353	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N16961_VC01355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N16961_VC01358	COG2996	Protein conserved in bacteria
N16961_VC01359	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
N16961_VC01359	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N16961_VC01360	COG3008	intermembrane lipid transfer
N16961_VC01361	COG2995	paraquat-inducible protein a
N16961_VC01362	COG1132	(ABC) transporter
N16961_VC01363	COG1956	GAF domain-containing protein
N16961_VC01364	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
N16961_VC01367	COG0308	aminopeptidase N
N16961_VC01369	COG0167	dihydroorotate dehydrogenase activity
N16961_VC01372	COG0116	Belongs to the methyltransferase superfamily
N16961_VC01372	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N16961_VC01377	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N16961_VC01378	COG1067	ATP-dependent peptidase activity
N16961_VC01379	COG3120	sequence-specific DNA binding
N16961_VC01396	COG1476	TRANSCRIPTIONal
N16961_VC01403	COG4128	Pfam Zonular occludens toxin
N16961_VC01406	COG1476	TRANSCRIPTIONal
N16961_VC01410	COG1476	TRANSCRIPTIONal
N16961_VC01414	COG3064	Membrane
N16961_VC01414	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
N16961_VC01414	COG1073	alpha beta
N16961_VC01415	COG2994	toxin metabolic process
N16961_VC01420	COG0784	Response regulator, receiver
N16961_VC01420	COG2205	protein histidine kinase activity
N16961_VC01423	COG3278	Belongs to the heme-copper respiratory oxidase family
N16961_VC01426	COG2010	Cytochrome c
N16961_VC01428	COG2217	Heavy metal translocating P-type atpase
N16961_VC01431	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N16961_VC01432	COG0589	response to stress
N16961_VC01433	COG0037	tRNA processing
N16961_VC01437	COG3842	ATPase activity
N16961_VC01438	COG1176	ABC-type spermidine putrescine transport system, permease component I
N16961_VC01439	COG1177	transmembrane transport
N16961_VC01440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N16961_VC01441	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N16961_VC01445	COG1115	amino acid carrier protein
N16961_VC01446	COG1280	lysine exporter protein (LysE YggA)
N16961_VC01451	COG3501	Rhs element vgr protein
N16961_VC01453	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N16961_VC01454	COG0840	transmembrane signaling receptor activity
N16961_VC01455	COG2814	Major facilitator Superfamily
N16961_VC01456	COG1566	PFAM secretion protein HlyD family protein
N16961_VC01457	COG1538	Outer membrane efflux protein
N16961_VC01459	COG0513	Belongs to the DEAD box helicase family
N16961_VC01461	COG0840	transmembrane signaling receptor activity
N16961_VC01462	COG3290	protein histidine kinase activity
N16961_VC01462	COG0840	transmembrane signaling receptor activity
N16961_VC01463	COG0835	chemotaxis
N16961_VC01464	COG2201	protein-glutamate methylesterase activity
N16961_VC01466	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N16961_VC01468	COG0643	Histidine kinase
N16961_VC01468	COG2198	Histidine kinase
N16961_VC01472	COG2076	Multidrug Resistance protein
N16961_VC01473	COG0415	Belongs to the DNA photolyase family
N16961_VC01474	COG0477	Major facilitator Superfamily
N16961_VC01475	COG0583	DNA-binding transcription factor activity
N16961_VC01476	COG0095	Lipoate-protein ligase
N16961_VC01477	COG0443	Heat shock 70 kDa protein
N16961_VC01479	COG1643	Atp-dependent helicase
N16961_VC01486	COG0443	Heat shock 70 kDa protein
N16961_VC01487	COG0443	Heat shock 70 kDa protein
N16961_VC01488	COG3706	GGDEF domain
N16961_VC01494	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N16961_VC01495	COG0602	queuosine metabolic process
N16961_VC01497	COG0561	phosphatase activity
N16961_VC01499	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_VC01500	COG4597	amino acid ABC transporter
N16961_VC01501	COG0765	amino acid transport
N16961_VC01502	COG1126	abc transporter atp-binding protein
N16961_VC01503	COG0670	Belongs to the BI1 family
N16961_VC01504	COG2920	part of a sulfur-relay system
N16961_VC01505	COG1254	Belongs to the acylphosphatase family
N16961_VC01506	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N16961_VC01507	COG3706	GGDEF domain
N16961_VC01510	COG3437	response regulator, receiver
N16961_VC01511	COG0625	glutathione transferase activity
N16961_VC01513	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N16961_VC01515	COG2195	Cleaves the N-terminal amino acid of tripeptides
N16961_VC01521	COG0372	Belongs to the citrate synthase family
N16961_VC01522	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N16961_VC01523	COG2186	Transcriptional regulator
N16961_VC01531	COG1129	ABC transporter
N16961_VC01536	COG0745	RESPONSE REGULATOR receiver
N16961_VC01537	COG2205	protein histidine kinase activity
N16961_VC01538	COG3713	MltA-interacting MipA family protein
N16961_VC01539	COG2990	Protein conserved in bacteria
N16961_VC01541	COG4191	Histidine kinase
N16961_VC01541	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_VC01542	COG0471	metal ion transport
N16961_VC01544	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N16961_VC01547	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_VC01548	COG3283	Transcriptional regulator of aromatic amino acids metabolism
N16961_VC01549	COG3768	UPF0283 membrane protein
N16961_VC01550	COG3106	COG3106 Predicted ATPase
N16961_VC01553	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N16961_VC01554	COG0494	nUDIX hydrolase
N16961_VC01555	COG0814	amino acid
N16961_VC01556	COG1760	l-serine dehydratase
N16961_VC01557	COG0720	synthase
N16961_VC01559	COG0017	Asparaginyl-tRNA synthetase
N16961_VC01560	COG0351	phosphomethylpyrimidine kinase
N16961_VC01561	COG2770	Histidine kinase
N16961_VC01561	COG3437	response regulator, receiver
N16961_VC01562	COG1448	Aminotransferase
N16961_VC01566	COG0840	transmembrane signaling receptor activity
N16961_VC01567	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
N16961_VC01568	COG2943	transferase activity, transferring hexosyl groups
N16961_VC01569	COG1609	Transcriptional regulator
N16961_VC01570	COG3394	polysaccharide catabolic process
N16961_VC01571	COG1486	melibiose metabolic process
N16961_VC01572	COG1447	Phosphotransferase system cellobiose-specific component IIA
N16961_VC01574	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N16961_VC01575	COG0726	polysaccharide deacetylase
N16961_VC01576	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N16961_VC01577	COG1846	Transcriptional regulator
N16961_VC01582	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N16961_VC01585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N16961_VC01586	COG3108	Peptidase M15
N16961_VC01587	COG2989	Protein conserved in bacteria
N16961_VC01592	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N16961_VC01594	COG2814	Major facilitator Superfamily
N16961_VC01598	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N16961_VC01599	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N16961_VC01600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N16961_VC01609	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
N16961_VC01610	COG4139	cobalamin transport
N16961_VC01611	COG2988	succinylglutamate desuccinylase activity
N16961_VC01614	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N16961_VC01615	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N16961_VC01616	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_VC01618	COG2925	Exonuclease
N16961_VC01620	COG1346	cytolysis
N16961_VC01621	COG0295	cytidine deaminase activity
N16961_VC01623	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N16961_VC01624	COG0500	methyltransferase
N16961_VC01627	COG0776	regulation of translation
N16961_VC01628	COG0072	phenylalanine-tRNA ligase activity
N16961_VC01628	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_VC01629	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N16961_VC01631	COG3706	GGDEF domain
N16961_VC01631	COG0745	RESPONSE REGULATOR receiver
N16961_VC01637	COG0322	excinuclease ABC activity
N16961_VC01638	COG2197	response regulator
N16961_VC01639	COG0417	DNA replication proofreading
N16961_VC01640	COG5001	Diguanylate cyclase
N16961_VC01642	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N16961_VC01646	COG1228	amidohydrolase
N16961_VC01647	COG0010	Belongs to the arginase family
N16961_VC01648	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N16961_VC01649	COG2986	histidine ammonia-lyase
N16961_VC01653	COG0277	FAD linked oxidase domain protein
N16961_VC01653	COG0247	lactate metabolic process
N16961_VC01656	COG2885	chlorophyll binding
N16961_VC01660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N16961_VC01662	COG0281	malic enzyme
N16961_VC01664	COG2949	membrane
N16961_VC01665	COG3706	GGDEF domain
N16961_VC01666	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N16961_VC01668	COG0492	ferredoxin-NADP+ reductase activity
N16961_VC01669	COG4988	ABC transporter
N16961_VC01670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N16961_VC01671	COG1187	pseudouridine synthase activity
N16961_VC01672	COG0009	L-threonylcarbamoyladenylate synthase
N16961_VC01673	COG0613	PHP domain protein
N16961_VC01675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N16961_VC01676	COG0512	Glutamine amidotransferase of anthranilate synthase
N16961_VC01677	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N16961_VC01678	COG0134	indole-3-glycerol-phosphate synthase activity
N16961_VC01678	COG0135	phosphoribosylanthranilate isomerase activity
N16961_VC01679	COG0133	tryptophan synthase activity
N16961_VC01680	COG0159	tryptophan synthase activity
N16961_VC01682	COG1435	thymidine kinase activity
N16961_VC01683	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N16961_VC01684	COG1801	Protein of unknown function DUF72
N16961_VC01685	COG4106	trans-aconitate 2-methyltransferase activity
N16961_VC01686	COG0500	methyltransferase
N16961_VC01687	COG0189	ligase activity
N16961_VC01687	COG4067	protein conserved in archaea
N16961_VC01690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N16961_VC01692	COG3852	Histidine kinase
N16961_VC01695	COG3070	regulator of competence-specific genes
N16961_VC01697	COG2431	L-lysine efflux transmembrane transporter activity
N16961_VC01699	COG0076	glutamate decarboxylase activity
N16961_VC01700	COG1737	Transcriptional regulator
N16961_VC01701	COG1012	belongs to the aldehyde dehydrogenase family
N16961_VC01701	COG1454	alcohol dehydrogenase
N16961_VC01702	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N16961_VC01704	COG0542	response to heat
N16961_VC01705	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N16961_VC01706	COG1278	Cold shock
N16961_VC01708	COG1187	pseudouridine synthase activity
N16961_VC01709	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N16961_VC01709	COG0140	phosphoribosyl-ATP diphosphatase activity
N16961_VC01710	COG0107	imidazoleglycerol-phosphate synthase activity
N16961_VC01711	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N16961_VC01712	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N16961_VC01713	COG0131	Imidazoleglycerol-phosphate dehydratase
N16961_VC01713	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N16961_VC01714	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N16961_VC01715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N16961_VC01716	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N16961_VC01718	COG1757	Na H antiporter
N16961_VC01720	COG2916	Histone family protein nucleoid-structuring protein H-NS
N16961_VC01721	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_VC01722	COG0482	sulfurtransferase activity
N16961_VC01723	COG2915	High frequency lysogenization protein hflD homolog
N16961_VC01724	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N16961_VC01726	COG2268	Band 7 protein
N16961_VC01728	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N16961_VC01731	COG0300	oxidoreductase activity
N16961_VC01733	COG0501	Belongs to the peptidase M48B family
N16961_VC01735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N16961_VC01736	COG2226	methyltransferase
N16961_VC01737	COG0156	8-amino-7-oxononanoate synthase activity
N16961_VC01738	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N16961_VC01739	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N16961_VC01740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N16961_VC01741	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N16961_VC01742	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N16961_VC01744	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N16961_VC01745	COG2199	diguanylate cyclase activity
N16961_VC01745	COG2203	Gaf domain
N16961_VC01747	COG4120	Belongs to the binding-protein-dependent transport system permease family
N16961_VC01749	COG4628	conserved protein (DUF2132)
N16961_VC01750	COG3092	negative regulation of chromosome organization
N16961_VC01751	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N16961_VC01752	COG0857	belongs to the CobB CobQ family
N16961_VC01752	COG0280	phosphate acetyltransferase
N16961_VC01753	COG0435	Glutathione S-transferase
N16961_VC01754	COG4608	Belongs to the ABC transporter superfamily
N16961_VC01755	COG0444	Belongs to the ABC transporter superfamily
N16961_VC01756	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_VC01757	COG0601	transmembrane transport
N16961_VC01761	COG2204	response regulator
N16961_VC01762	COG3300	MHYT domain
N16961_VC01762	COG5001	Diguanylate cyclase
N16961_VC01763	COG4191	Histidine kinase
N16961_VC01764	COG5002	protein histidine kinase activity
N16961_VC01766	COG2201	protein-glutamate methylesterase activity
N16961_VC01769	COG0009	L-threonylcarbamoyladenylate synthase
N16961_VC01772	COG1881	PFAM PEBP family protein
N16961_VC01777	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N16961_VC01778	COG0640	Transcriptional regulator
N16961_VC01780	COG3706	GGDEF domain
N16961_VC01784	COG1946	Acyl-CoA thioesterase
N16961_VC01785	COG1522	sequence-specific DNA binding
N16961_VC01787	COG0616	signal peptide processing
N16961_VC01788	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_VC01791	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N16961_VC01792	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N16961_VC01794	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N16961_VC01795	COG2832	Protein of unknown function (DUF454)
N16961_VC01797	COG0745	RESPONSE REGULATOR receiver
N16961_VC01798	COG0583	DNA-binding transcription factor activity
N16961_VC01799	COG0778	Nitroreductase
N16961_VC01800	COG1024	Enoyl-CoA hydratase
N16961_VC01800	COG1250	3-hydroxyacyl-CoA dehydrogenase
N16961_VC01801	COG0183	Belongs to the thiolase family
N16961_VC01804	COG2067	long-chain fatty acid transport protein
N16961_VC01806	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N16961_VC01807	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
N16961_VC01808	COG2982	Protein involved in outer membrane biogenesis
N16961_VC01809	COG0572	uridine kinase
N16961_VC01810	COG0489	protein tyrosine kinase activity
N16961_VC01811	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_VC01811	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_VC01813	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N16961_VC01815	COG4109	DRTGG domain
N16961_VC01816	COG2199	diguanylate cyclase activity
N16961_VC01817	COG0314	molybdopterin synthase activity
N16961_VC01818	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N16961_VC01819	COG0315	cyclic pyranopterin monophosphate synthase activity
N16961_VC01820	COG0521	Mo-molybdopterin cofactor biosynthetic process
N16961_VC01821	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N16961_VC01823	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N16961_VC01824	COG2198	Histidine kinase
N16961_VC01825	COG2204	response regulator
N16961_VC01827	COG0556	nucleotide-excision repair
N16961_VC01829	COG4657	Part of a membrane complex involved in electron transport
N16961_VC01830	COG2878	Part of a membrane complex involved in electron transport
N16961_VC01831	COG4656	Part of a membrane complex involved in electron transport
N16961_VC01832	COG4658	electron transport chain
N16961_VC01833	COG4659	FMN binding
N16961_VC01834	COG4660	Part of a membrane complex involved in electron transport
N16961_VC01835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N16961_VC01836	COG0346	lactoylglutathione lyase activity
N16961_VC01839	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N16961_VC01840	COG2056	Na+-H+ antiporter family
N16961_VC01841	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N16961_VC01842	COG1286	toxin biosynthetic process
N16961_VC01843	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
N16961_VC01844	COG0285	dihydrofolate synthase activity
N16961_VC01845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N16961_VC01846	COG0101	tRNA pseudouridine synthase activity
N16961_VC01848	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N16961_VC01849	COG1263	PTS System
N16961_VC01849	COG2190	(PTS) system
N16961_VC01849	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_VC01850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N16961_VC01851	COG1846	Transcriptional regulator
N16961_VC01851	COG1940	carbohydrate kinase activity
N16961_VC01852	COG4651	solute:proton antiporter activity
N16961_VC01852	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N16961_VC01853	COG0367	asparagine synthase
N16961_VC01856	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N16961_VC01857	COG0563	adenylate kinase activity
N16961_VC01858	COG0326	Molecular chaperone. Has ATPase activity
N16961_VC01859	COG3710	Transcriptional regulator
N16961_VC01862	COG0622	Phosphoesterase
N16961_VC01863	COG1090	epimerase
N16961_VC01864	COG0300	oxidoreductase activity
N16961_VC01865	COG3118	belongs to the thioredoxin family
N16961_VC01866	COG0330	HflC and HflK could
N16961_VC01867	COG1585	Membrane protein implicated in regulation of membrane protease activity
N16961_VC01868	COG0789	Transcriptional regulator
N16961_VC01871	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N16961_VC01872	COG3115	cell septum assembly
N16961_VC01873	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
N16961_VC01874	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N16961_VC01875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_VC01877	COG2190	(PTS) system
N16961_VC01878	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_VC01879	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N16961_VC01880	COG1702	phosphate starvation-inducible protein PhoH
N16961_VC01881	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N16961_VC01882	COG4535	Mg2 and Co2 transporter CorC
N16961_VC01883	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N16961_VC01884	COG2888	peptidyl-tyrosine sulfation
N16961_VC01885	COG0495	leucyl-tRNA aminoacylation
N16961_VC01886	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N16961_VC01887	COG1466	dna polymerase III delta subunit
N16961_VC01888	COG0799	negative regulation of ribosome biogenesis
N16961_VC01889	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N16961_VC01890	COG0768	penicillin binding
N16961_VC01891	COG0772	Belongs to the SEDS family
N16961_VC01892	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N16961_VC01893	COG1686	Belongs to the peptidase S11 family
N16961_VC01894	COG2921	Belongs to the UPF0250 family
N16961_VC01895	COG0321	lipoyl(octanoyl) transferase activity
N16961_VC01896	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N16961_VC01898	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N16961_VC01903	COG1596	polysaccharide export
N16961_VC01905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N16961_VC01911	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N16961_VC01913	COG0438	transferase activity, transferring glycosyl groups
N16961_VC01915	COG1045	serine acetyltransferase
N16961_VC01919	COG0110	maltose O-acetyltransferase activity
N16961_VC01920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N16961_VC01921	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N16961_VC01924	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N16961_VC01930	COG0366	Alpha amylase catalytic
N16961_VC01931	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_VC01931	COG1263	PTS System
N16961_VC01932	COG1609	Transcriptional regulator
N16961_VC01933	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N16961_VC01934	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N16961_VC01935	COG2011	ABC-type metal ion transport system permease component
N16961_VC01936	COG1464	Belongs to the NlpA lipoprotein family
N16961_VC01937	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N16961_VC01939	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N16961_VC01939	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N16961_VC01941	COG3706	GGDEF domain
N16961_VC01942	COG1611	Belongs to the LOG family
N16961_VC01943	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N16961_VC01944	COG2363	Small membrane protein
N16961_VC01945	COG0583	DNA-binding transcription factor activity
N16961_VC01947	COG0301	tRNA thio-modification
N16961_VC01947	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N16961_VC01949	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N16961_VC01950	COG1722	exodeoxyribonuclease VII activity
N16961_VC01951	COG0142	geranyltranstransferase activity
N16961_VC01952	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N16961_VC01953	COG0564	pseudouridine synthase activity
N16961_VC01954	COG3098	single-species biofilm formation
N16961_VC01957	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_VC01960	COG1671	Belongs to the UPF0178 family
N16961_VC01961	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N16961_VC01962	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N16961_VC01963	COG0254	rRNA binding
N16961_VC01964	COG1720	tRNA m6t6A37 methyltransferase activity
N16961_VC01965	COG0442	prolyl-tRNA aminoacylation
N16961_VC01969	COG1943	Transposase
N16961_VC01970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N16961_VC01970	COG0047	phosphoribosylformylglycinamidine synthase activity
N16961_VC01971	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N16961_VC01973	COG0590	tRNA wobble adenosine to inosine editing
N16961_VC01974	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N16961_VC01980	COG0484	heat shock protein binding
N16961_VC01981	COG0443	Heat shock 70 kDa protein
N16961_VC01982	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N16961_VC01983	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N16961_VC01984	COG0497	DNA recombination
N16961_VC01985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N16961_VC01986	COG2914	Belongs to the UPF0125 (RnfH) family
N16961_VC01987	COG2867	negative regulation of translational initiation
N16961_VC01988	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N16961_VC01991	COG0582	viral genome integration into host DNA
N16961_VC01993	COG3064	Membrane
N16961_VC01995	COG0739	heme binding
N16961_VC02000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
N16961_VC02001	COG2207	Transcriptional regulator
N16961_VC02003	COG1459	type II secretion system
N16961_VC02004	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_VC02008	COG4796	Type ii and iii secretion system protein
N16961_VC02011	COG2165	general secretion pathway protein
N16961_VC02013	COG3710	Transcriptional regulator
N16961_VC02015	COG0840	transmembrane signaling receptor activity
N16961_VC02016	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N16961_VC02021	COG1012	belongs to the aldehyde dehydrogenase family
N16961_VC02032	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N16961_VC02033	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N16961_VC02034	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N16961_VC02036	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N16961_VC02037	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
N16961_VC02038	COG3051	citrate lyase alpha subunit
N16961_VC02039	COG2301	Belongs to the HpcH HpaI aldolase family
N16961_VC02040	COG3052	prosthetic group binding
N16961_VC02041	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
N16961_VC02043	COG3630	sodium ion export across plasma membrane
N16961_VC02044	COG0511	ligase activity, forming carbon-carbon bonds
N16961_VC02044	COG5016	pyruvate
N16961_VC02045	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N16961_VC02047	COG4565	transcriptional regulatory protein
N16961_VC02050	COG0583	DNA-binding transcription factor activity
N16961_VC02051	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N16961_VC02052	COG1115	amino acid carrier protein
N16961_VC02053	COG2015	COG2015, Alkyl sulfatase and related hydrolases
N16961_VC02054	COG0583	DNA-binding transcription factor activity
N16961_VC02056	COG1120	ATPase activity
N16961_VC02057	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_VC02058	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_VC02059	COG4592	Periplasmic binding protein
N16961_VC02061	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_VC02062	COG1169	isochorismate synthase
N16961_VC02063	COG1021	2,3-dihydroxybenzoate-AMP ligase
N16961_VC02064	COG3433	isochorismatase activity
N16961_VC02064	COG1535	isochorismatase
N16961_VC02065	COG1584	GPR1 FUN34 yaaH family protein
N16961_VC02067	COG0519	Catalyzes the synthesis of GMP from XMP
N16961_VC02067	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N16961_VC02068	COG0516	GMP reductase activity
N16961_VC02068	COG0517	IMP dehydrogenase activity
N16961_VC02069	COG1570	exodeoxyribonuclease VII activity
N16961_VC02072	COG1160	GTP binding
N16961_VC02073	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N16961_VC02074	COG2976	Protein conserved in bacteria
N16961_VC02075	COG0124	histidyl-tRNA synthetase
N16961_VC02076	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N16961_VC02078	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N16961_VC02079	COG0105	UTP biosynthetic process
N16961_VC02080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N16961_VC02081	COG2975	iron-sulfur cluster assembly
N16961_VC02082	COG0633	Ferredoxin
N16961_VC02083	COG0443	Heat shock 70 kDa protein
N16961_VC02084	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N16961_VC02086	COG0822	iron-sulfur transferase activity
N16961_VC02087	COG1104	cysteine desulfurase activity
N16961_VC02088	COG1959	2 iron, 2 sulfur cluster binding
N16961_VC02090	COG0483	inositol monophosphate 1-phosphatase activity
N16961_VC02091	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_VC02092	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_VC02093	COG1862	Preprotein translocase
N16961_VC02094	COG0343	queuine tRNA-ribosyltransferase activity
N16961_VC02095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N16961_VC02096	COG0517	IMP dehydrogenase activity
N16961_VC02098	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N16961_VC02099	COG0583	DNA-binding transcription factor activity
N16961_VC02100	COG0450	alkyl hydroperoxide reductase
N16961_VC02101	COG3142	Participates in the control of copper homeostasis
N16961_VC02104	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N16961_VC02105	COG0581	inorganic phosphate transmembrane transporter activity
N16961_VC02107	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N16961_VC02108	COG0248	Ppx GppA phosphatase
N16961_VC02110	COG5002	protein histidine kinase activity
N16961_VC02111	COG0745	RESPONSE REGULATOR receiver
N16961_VC02112	COG2974	May be involved in recombination
N16961_VC02114	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N16961_VC02121	COG0542	response to heat
N16961_VC02123	COG0564	pseudouridine synthase activity
N16961_VC02124	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N16961_VC02125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N16961_VC02127	COG1605	Chorismate mutase
N16961_VC02127	COG0077	Prephenate dehydratase
N16961_VC02128	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N16961_VC02129	COG5001	Diguanylate cyclase
N16961_VC02130	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
N16961_VC02131	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
N16961_VC02133	COG0488	(ABC) transporter
N16961_VC02135	COG0287	Prephenate dehydrogenase
N16961_VC02135	COG1605	Chorismate mutase
N16961_VC02136	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N16961_VC02137	COG3275	phosphorelay sensor kinase activity
N16961_VC02138	COG3279	Response regulator of the LytR AlgR family
N16961_VC02139	COG1472	Belongs to the glycosyl hydrolase 3 family
N16961_VC02140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N16961_VC02141	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N16961_VC02144	COG1966	Carbon starvation protein
N16961_VC02145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N16961_VC02146	COG1047	Peptidyl-prolyl cis-trans
N16961_VC02147	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N16961_VC02148	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N16961_VC02149	COG0196	riboflavin kinase activity
N16961_VC02150	COG0728	peptidoglycan biosynthetic process
N16961_VC02151	COG0268	Binds directly to 16S ribosomal RNA
N16961_VC02152	COG0640	Transcriptional regulator
N16961_VC02153	COG0583	DNA-binding transcription factor activity
N16961_VC02154	COG1283	sodium-dependent phosphate transmembrane transporter activity
N16961_VC02155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N16961_VC02156	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N16961_VC02157	COG0730	response to heat
N16961_VC02158	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
N16961_VC02159	COG0494	nUDIX hydrolase
N16961_VC02160	COG3066	DNA modification
N16961_VC02161	COG0667	Aldo Keto reductase
N16961_VC02163	COG2204	response regulator
N16961_VC02164	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N16961_VC02165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N16961_VC02167	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N16961_VC02168	COG0513	Belongs to the DEAD box helicase family
N16961_VC02169	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N16961_VC02173	COG3153	acetyltransferase
N16961_VC02180	COG4785	May be involved in cell division
N16961_VC02181	COG1185	polyribonucleotide nucleotidyltransferase activity
N16961_VC02182	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N16961_VC02184	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N16961_VC02185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N16961_VC02186	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N16961_VC02187	COG0195	Participates in both transcription termination and antitermination
N16961_VC02188	COG0779	Required for maturation of 30S ribosomal subunits
N16961_VC02192	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N16961_VC02194	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N16961_VC02195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N16961_VC02196	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N16961_VC02197	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N16961_VC02198	COG1534	Rna-binding protein
N16961_VC02199	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N16961_VC02200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N16961_VC02201	COG2027	D-alanyl-D-alanine carboxypeptidase
N16961_VC02202	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N16961_VC02203	COG0739	heme binding
N16961_VC02206	COG0316	Belongs to the HesB IscA family
N16961_VC02207	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N16961_VC02209	COG0628	permease
N16961_VC02210	COG2813	Specifically methylates the guanine in position
N16961_VC02212	COG0747	negative chemotaxis
N16961_VC02213	COG0601	transmembrane transport
N16961_VC02214	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_VC02215	COG0444	Belongs to the ABC transporter superfamily
N16961_VC02216	COG4608	Belongs to the ABC transporter superfamily
N16961_VC02218	COG2971	BadF BadG BcrA BcrD
N16961_VC02222	COG3842	ATPase activity
N16961_VC02224	COG1840	ABC-type Fe3 transport system, periplasmic component
N16961_VC02225	COG0004	ammonium transporteR
N16961_VC02226	COG0347	Belongs to the P(II) protein family
N16961_VC02227	COG3112	Uncharacterised protein family (UPF0231)
N16961_VC02228	COG1049	propionate catabolic process, 2-methylcitrate cycle
N16961_VC02229	COG1752	Esterase of the alpha-beta hydrolase superfamily
N16961_VC02230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N16961_VC02231	COG1643	Atp-dependent helicase
N16961_VC02233	COG1489	DNA binding
N16961_VC02234	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N16961_VC02235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N16961_VC02237	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N16961_VC02238	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N16961_VC02239	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N16961_VC02240	COG0842	Transport permease protein
N16961_VC02241	COG1131	(ABC) transporter
N16961_VC02242	COG0659	secondary active sulfate transmembrane transporter activity
N16961_VC02243	COG0288	reversible hydration of carbon dioxide
N16961_VC02247	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N16961_VC02248	COG3107	peptidoglycan biosynthetic process
N16961_VC02249	COG0792	nuclease activity
N16961_VC02250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N16961_VC02251	COG2823	Periplasmic or secreted lipoprotein
N16961_VC02252	COG2969	positive regulation of protein catabolic process
N16961_VC02253	COG0625	glutathione transferase activity
N16961_VC02254	COG2857	Cytochrome c1
N16961_VC02255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N16961_VC02256	COG0723	plastoquinol--plastocyanin reductase activity
N16961_VC02257	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N16961_VC02258	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N16961_VC02259	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N16961_VC02261	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N16961_VC02262	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N16961_VC02263	COG0335	large ribosomal subunit rRNA binding
N16961_VC02264	COG0336	Belongs to the RNA methyltransferase TrmD family
N16961_VC02265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N16961_VC02266	COG0228	four-way junction DNA binding
N16961_VC02267	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N16961_VC02268	COG4137	Cytochrome C assembly protein
N16961_VC02269	COG4536	flavin adenine dinucleotide binding
N16961_VC02270	COG1854	S-ribosylhomocysteine lyase activity
N16961_VC02271	COG2918	glutathione biosynthetic process
N16961_VC02272	COG0612	Peptidase, M16
N16961_VC02273	COG1238	metal cluster binding
N16961_VC02275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N16961_VC02276	COG0511	ligase activity, forming carbon-carbon bonds
N16961_VC02276	COG5016	pyruvate
N16961_VC02277	COG3630	sodium ion export across plasma membrane
N16961_VC02286	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N16961_VC02287	COG0527	aspartate kinase activity
N16961_VC02288	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N16961_VC02289	COG2137	regulation of response to DNA damage stimulus
N16961_VC02290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N16961_VC02292	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N16961_VC02293	COG4208	sulfate ABC transporter
N16961_VC02297	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N16961_VC02298	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N16961_VC02299	COG4942	peptidase
N16961_VC02299	COG1388	LysM domain
N16961_VC02300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N16961_VC02301	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N16961_VC02302	COG0585	pseudouridine synthase activity
N16961_VC02303	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N16961_VC02304	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N16961_VC02305	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N16961_VC02306	COG1968	undecaprenyl-diphosphatase activity
N16961_VC02307	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N16961_VC02308	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N16961_VC02309	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N16961_VC02311	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N16961_VC02312	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N16961_VC02313	COG1610	YqeY-like protein
N16961_VC02314	COG0358	DNA primase activity
N16961_VC02315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N16961_VC02317	COG0582	viral genome integration into host DNA
N16961_VC02318	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N16961_VC02320	COG2207	Transcriptional regulator
N16961_VC02321	COG0840	transmembrane signaling receptor activity
N16961_VC02323	COG2003	Belongs to the UPF0758 family
N16961_VC02329	COG0739	heme binding
N16961_VC02334	COG0328	RNA-DNA hybrid ribonuclease activity
N16961_VC02344	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N16961_VC02345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N16961_VC02346	COG1349	DNA-binding transcription factor activity
N16961_VC02347	COG0469	pyruvate kinase activity
N16961_VC02350	COG0583	DNA-binding transcription factor activity
N16961_VC02351	COG1279	arginine transmembrane transporter activity
N16961_VC02352	COG0668	transmembrane transport
N16961_VC02353	COG0191	fructose-bisphosphate aldolase activity
N16961_VC02354	COG0126	phosphoglycerate kinase activity
N16961_VC02355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N16961_VC02356	COG4771	TonB-dependent receptor
N16961_VC02357	COG0583	DNA-binding transcription factor activity
N16961_VC02358	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N16961_VC02359	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N16961_VC02360	COG3091	SprT-like family
N16961_VC02361	COG2356	endonuclease I
N16961_VC02362	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N16961_VC02363	COG0189	ligase activity
N16961_VC02364	COG1678	Uncharacterized ACR, COG1678
N16961_VC02365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N16961_VC02366	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N16961_VC02370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N16961_VC02371	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N16961_VC02372	COG0762	integral membrane protein
N16961_VC02373	COG1872	DUF167
N16961_VC02375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N16961_VC02376	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N16961_VC02377	COG2066	Belongs to the glutaminase family
N16961_VC02378	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N16961_VC02379	COG1194	a g-specific adenine glycosylase
N16961_VC02380	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N16961_VC02381	COG0741	lytic transglycosylase activity
N16961_VC02392	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N16961_VC02393	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N16961_VC02394	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N16961_VC02395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N16961_VC02396	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N16961_VC02397	COG2967	ApaG domain
N16961_VC02398	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N16961_VC02400	COG3610	response to peptide
N16961_VC02401	COG2966	Psort location CytoplasmicMembrane, score
N16961_VC02402	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N16961_VC02403	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N16961_VC02404	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N16961_VC02405	COG0142	geranyltranstransferase activity
N16961_VC02406	COG0531	amino acid
N16961_VC02407	COG0039	L-malate dehydrogenase activity
N16961_VC02408	COG1438	arginine binding
N16961_VC02411	COG0589	response to stress
N16961_VC02415	COG2235	arginine
N16961_VC02416	COG0312	modulator of DNA gyrase
N16961_VC02417	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N16961_VC02418	COG3164	Protein of unknown function
N16961_VC02419	COG1530	ribonuclease E activity
N16961_VC02420	COG0424	maF-like protein
N16961_VC02421	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N16961_VC02422	COG1792	Involved in formation and maintenance of cell shape
N16961_VC02423	COG1077	Cell shape determining protein MreB Mrl
N16961_VC02432	COG1459	type II secretion system
N16961_VC02433	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_VC02435	COG3409	Peptidoglycan-binding domain 1 protein
N16961_VC02435	COG3267	Type II secretory pathway component ExeA
N16961_VC02440	COG2200	EAL domain
N16961_VC02440	COG2199	diguanylate cyclase activity
N16961_VC02441	COG0629	single-stranded DNA binding
N16961_VC02444	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N16961_VC02446	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N16961_VC02448	COG0527	aspartate kinase activity
N16961_VC02449	COG1410	methionine synthase
N16961_VC02449	COG0646	methionine synthase
N16961_VC02465	COG0175	sulfate reduction
N16961_VC02466	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N16961_VC02467	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N16961_VC02471	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N16961_VC02472	COG0735	belongs to the Fur family
N16961_VC02475	COG0166	Belongs to the GPI family
N16961_VC02476	COG0432	Pfam Uncharacterised protein family UPF0047
N16961_VC02477	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N16961_VC02478	COG0305	Participates in initiation and elongation during chromosome replication
N16961_VC02480	COG0359	binds to the 23S rRNA
N16961_VC02481	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N16961_VC02482	COG2965	DNA replication, synthesis of RNA primer
N16961_VC02483	COG0360	Binds together with S18 to 16S ribosomal RNA
N16961_VC02485	COG2906	2 iron, 2 sulfur cluster binding
N16961_VC02486	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N16961_VC02487	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N16961_VC02488	COG0049	tRNA binding
N16961_VC02489	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N16961_VC02491	COG2923	Belongs to the DsrF TusC family
N16961_VC02492	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N16961_VC02493	COG2964	Protein conserved in bacteria
N16961_VC02494	COG0545	Peptidyl-prolyl cis-trans isomerase
N16961_VC02496	COG2900	Belongs to the SlyX family
N16961_VC02497	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
N16961_VC02498	COG0330	HflC and HflK could
N16961_VC02499	COG0330	HflC and HflK could
N16961_VC02500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N16961_VC02501	COG1923	regulation of RNA biosynthetic process
N16961_VC02502	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N16961_VC02503	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N16961_VC02505	COG0802	atpase or kinase
N16961_VC02506	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N16961_VC02515	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N16961_VC02516	COG1162	GTPase activity
N16961_VC02517	COG0688	phosphatidylethanolamine metabolic process
N16961_VC02518	COG0471	metal ion transport
N16961_VC02520	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N16961_VC02521	COG4942	peptidase
N16961_VC02524	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N16961_VC02525	COG2816	NAD+ diphosphatase activity
N16961_VC02526	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
N16961_VC02527	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N16961_VC02528	COG0085	RNA polymerase activity
N16961_VC02530	COG0222	ribosome binding
N16961_VC02531	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N16961_VC02532	COG0081	regulation of translation
N16961_VC02533	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N16961_VC02534	COG0250	Participates in transcription elongation, termination and antitermination
N16961_VC02535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N16961_VC02536	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N16961_VC02541	COG1072	(Pantothenic acid kinase))
N16961_VC02543	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N16961_VC02545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N16961_VC02553	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N16961_VC02555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N16961_VC02556	COG3118	belongs to the thioredoxin family
N16961_VC02557	COG0513	Belongs to the DEAD box helicase family
N16961_VC02558	COG0248	Ppx GppA phosphatase
N16961_VC02559	COG2205	protein histidine kinase activity
N16961_VC02559	COG0784	Response regulator, receiver
N16961_VC02560	COG2814	Major facilitator Superfamily
N16961_VC02563	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N16961_VC02564	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N16961_VC02565	COG0511	ligase activity, forming carbon-carbon bonds
N16961_VC02566	COG0439	Biotin carboxylase
N16961_VC02567	COG2264	protein methyltransferase activity
N16961_VC02568	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N16961_VC02569	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N16961_VC02570	COG1609	Transcriptional regulator
N16961_VC02571	COG0129	dihydroxy-acid dehydratase activity
N16961_VC02572	COG3265	gluconokinase activity
N16961_VC02574	COG0800	Aldolase
N16961_VC02578	COG0840	transmembrane signaling receptor activity
N16961_VC02579	COG1982	Orn Lys Arg decarboxylase major
N16961_VC02580	COG0531	amino acid
N16961_VC02581	COG3710	Transcriptional regulator
N16961_VC02582	COG0789	Transcriptional regulator
N16961_VC02583	COG0138	bifunctional purine biosynthesis protein purh
N16961_VC02584	COG0151	Belongs to the GarS family
N16961_VC02586	COG0776	regulation of translation
N16961_VC02588	COG1253	flavin adenine dinucleotide binding
N16961_VC02589	COG1940	carbohydrate kinase activity
N16961_VC02591	COG3068	Protein conserved in bacteria
N16961_VC02593	COG1573	uracil-dna glycosylase
N16961_VC02594	COG0668	transmembrane transport
N16961_VC02595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N16961_VC02596	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N16961_VC02604	COG5433	transposase activity
N16961_VC02605	COG5433	transposase activity
N16961_VC02608	COG1454	alcohol dehydrogenase
N16961_VC02608	COG1012	belongs to the aldehyde dehydrogenase family
N16961_VC02609	COG0318	PFAM AMP-dependent synthetase and ligase
N16961_VC02615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
N16961_VC02616	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N16961_VC02617	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
N16961_VC02617	COG0662	Cupin 2, conserved barrel domain protein
N16961_VC02618	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N16961_VC02625	COG1519	Transferase
N16961_VC02631	COG3642	lipopolysaccharide core region biosynthetic process
N16961_VC02632	COG0859	PFAM glycosyl transferase family 9
N16961_VC02633	COG0463	Glycosyl transferase, family 2
N16961_VC02634	COG0859	PFAM glycosyl transferase family 9
N16961_VC02635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N16961_VC02636	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N16961_VC02638	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N16961_VC02639	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N16961_VC02642	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N16961_VC02643	COG1309	transcriptional regulator
N16961_VC02644	COG1560	Kdo2-lipid A biosynthetic process
N16961_VC02645	COG1560	Kdo2-lipid A biosynthetic process
N16961_VC02646	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N16961_VC02647	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N16961_VC02648	COG1561	YicC-like family, N-terminal region
N16961_VC02650	COG1263	PTS System
N16961_VC02650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_VC02651	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N16961_VC02655	COG1120	ATPase activity
N16961_VC02656	COG4774	siderophore transport
N16961_VC02657	COG1132	(ABC) transporter
N16961_VC02660	COG0514	ATP-dependent DNA helicase (RecQ)
N16961_VC02661	COG2962	Rard protein
N16961_VC02664	COG1280	lysine exporter protein (LysE YggA)
N16961_VC02666	COG0210	DNA helicase
N16961_VC02668	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N16961_VC02669	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_VC02682	COG2131	deaminase
N16961_VC02684	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_VC02686	COG0747	negative chemotaxis
N16961_VC02695	COG1309	transcriptional regulator
N16961_VC02696	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_VC02697	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N16961_VC02698	COG2960	long-chain fatty acid transporting porin activity
N16961_VC02699	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N16961_VC02700	COG0583	DNA-binding transcription factor activity
N16961_VC02707	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
N16961_VC02708	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N16961_VC02709	COG1739	Uncharacterized protein family UPF0029
N16961_VC02710	COG1024	Enoyl-CoA hydratase
N16961_VC02710	COG1250	3-hydroxyacyl-CoA dehydrogenase
N16961_VC02711	COG0183	Belongs to the thiolase family
N16961_VC02712	COG0583	DNA-binding transcription factor activity
N16961_VC02713	COG2814	Major facilitator Superfamily
N16961_VC02714	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N16961_VC02715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N16961_VC02716	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N16961_VC02717	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N16961_VC02718	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N16961_VC02719	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N16961_VC02720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N16961_VC02722	COG0356	it plays a direct role in the translocation of protons across the membrane
N16961_VC02723	COG3312	ion transport
N16961_VC02724	COG1475	DNA binding
N16961_VC02725	COG1192	Involved in chromosome partitioning
N16961_VC02726	COG0357	Ribosomal RNA small subunit methyltransferase G
N16961_VC02727	COG0445	tRNA wobble uridine modification
N16961_VC02728	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N16961_VC02729	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N16961_VC02730	COG0706	membrane insertase activity
N16961_VC02731	COG0594	ribonuclease P activity
N16961_VC02732	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N16961_VC02733	COG1126	abc transporter atp-binding protein
N16961_VCA02743	COG0217	transcriptional regulatory protein
N16961_VCA02744	COG2084	Dehydrogenase
N16961_VCA02747	COG2909	trisaccharide binding
N16961_VCA02748	COG0058	SHG alpha-glucan phosphorylase activity
N16961_VCA02749	COG1640	4-alpha-glucanotransferase
N16961_VCA02750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N16961_VCA02752	COG3501	Rhs element vgr protein
N16961_VCA02762	COG0471	metal ion transport
N16961_VCA02763	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N16961_VCA02772	COG0671	phosphoesterase, PA-phosphatase related
N16961_VCA02773	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N16961_VCA02775	COG1999	signal sequence binding
N16961_VCA02779	COG0786	glutamate:sodium symporter activity
N16961_VCA02783	COG1566	PFAM secretion protein HlyD family protein
N16961_VCA02785	COG3706	GGDEF domain
N16961_VCA02788	COG0813	purine-nucleoside phosphorylase activity
N16961_VCA02789	COG3272	Protein of unknown function (DUF1722)
N16961_VCA02791	COG0415	Belongs to the DNA photolyase family
N16961_VCA02792	COG1388	LysM domain
N16961_VCA02792	COG1376	ErfK ybiS ycfS ynhG family protein
N16961_VCA02794	COG0513	Belongs to the DEAD box helicase family
N16961_VCA02795	COG1770	oligopeptidase
N16961_VCA02801	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N16961_VCA02802	COG0573	inorganic phosphate transmembrane transporter activity
N16961_VCA02803	COG0581	inorganic phosphate transmembrane transporter activity
N16961_VCA02804	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N16961_VCA02808	COG0659	secondary active sulfate transmembrane transporter activity
N16961_VCA02810	COG0739	heme binding
N16961_VCA02811	COG5001	Diguanylate cyclase
N16961_VCA02811	COG3300	MHYT domain
N16961_VCA02813	COG0583	DNA-binding transcription factor activity
N16961_VCA02814	COG2814	Major facilitator Superfamily
N16961_VCA02819	COG1301	dicarboxylic acid transport
N16961_VCA02821	COG1342	Belongs to the UPF0251 family
N16961_VCA02827	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N16961_VCA02828	COG0673	inositol 2-dehydrogenase activity
N16961_VCA02830	COG2771	luxR family
N16961_VCA02830	COG2200	EAL domain
N16961_VCA02831	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N16961_VCA02833	COG0564	pseudouridine synthase activity
N16961_VCA02851	COG3501	Rhs element vgr protein
N16961_VCA02854	COG1869	D-ribose catabolic process
N16961_VCA02855	COG1129	ABC transporter
N16961_VCA02856	COG1172	Belongs to the binding-protein-dependent transport system permease family
N16961_VCA02857	COG1879	ABC-type sugar transport system periplasmic component
N16961_VCA02858	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_VCA02859	COG1609	Transcriptional regulator
N16961_VCA02861	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N16961_VCA02863	COG0584	glycerophosphoryl diester phosphodiesterase
N16961_VCA02864	COG2271	Major facilitator Superfamily
N16961_VCA02871	COG0579	oxidoreductase
N16961_VCA02873	COG0242	peptide deformylase activity
N16961_VCA02875	COG1320	monovalent cation:proton antiporter activity
N16961_VCA02876	COG2212	antiporter activity
N16961_VCA02880	COG2111	Na H antiporter
N16961_VCA02880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N16961_VCA02882	COG0589	response to stress
N16961_VCA02883	COG0814	amino acid
N16961_VCA02884	COG3033	Beta-eliminating lyase
N16961_VCA02886	COG3530	Putative quorum-sensing-regulated virulence factor
N16961_VCA02888	COG5002	protein histidine kinase activity
N16961_VCA02888	COG5001	Diguanylate cyclase
N16961_VCA02890	COG1278	Cold shock
N16961_VCA02893	COG2304	oxidoreductase activity
N16961_VCA02897	COG0714	Associated with various cellular activities
N16961_VCA02898	COG0840	transmembrane signaling receptor activity
N16961_VCA02901	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N16961_VCA02902	COG2195	Cleaves the N-terminal amino acid of tripeptides
N16961_VCA02904	COG3604	Transcriptional regulator
N16961_VCA02905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N16961_VCA02905	COG1017	nitric oxide dioxygenase activity
N16961_VCA02907	COG1278	Cold shock
N16961_VCA02908	COG3036	rescue of stalled ribosome
N16961_VCA02913	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N16961_VCA02913	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N16961_VCA02914	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N16961_VCA02916	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N16961_VCA02918	COG0516	GMP reductase activity
N16961_VCA02923	COG1943	Transposase
N16961_VCA02924	COG0513	Belongs to the DEAD box helicase family
N16961_VCA02925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N16961_VCA02926	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N16961_VCA02927	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N16961_VCA02929	COG3437	response regulator, receiver
N16961_VCA02929	COG0784	Response regulator, receiver
N16961_VCA02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_VCA02930	COG4191	Histidine kinase
N16961_VCA02932	COG1757	Na H antiporter
N16961_VCA02934	COG2814	Major facilitator Superfamily
N16961_VCA02935	COG3706	GGDEF domain
N16961_VCA02936	COG3240	lipase activity
N16961_VCA02938	COG0840	transmembrane signaling receptor activity
N16961_VCA02939	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N16961_VCA02940	COG5380	lipid catabolic process
N16961_VCA02941	COG4412	M6 family metalloprotease domain protein
N16961_VCA02941	COG3291	Pkd domain containing protein
N16961_VCA02945	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_VCA02946	COG4605	iron ion homeostasis
N16961_VCA02947	COG4604	ABC transporter, ATP-binding protein
N16961_VCA02951	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N16961_VCA02955	COG0745	RESPONSE REGULATOR receiver
N16961_VCA02957	COG3623	hexulose-6-phosphate isomerase
N16961_VCA02958	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N16961_VCA02959	COG0561	phosphatase activity
N16961_VCA02965	COG3038	cytochrome b561
N16961_VCA02966	COG0366	Alpha amylase catalytic
N16961_VCA02971	COG0745	RESPONSE REGULATOR receiver
N16961_VCA02972	COG5002	protein histidine kinase activity
N16961_VCA02977	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N16961_VCA02980	COG2814	Major facilitator Superfamily
N16961_VCA02983	COG1686	Belongs to the peptidase S11 family
N16961_VCA02987	COG1943	Transposase
N16961_VCA02988	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N16961_VCA02988	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N16961_VCA02989	COG0509	glycine decarboxylation via glycine cleavage system
N16961_VCA02990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N16961_VCA02992	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N16961_VCA02994	COG3039	Transposase
N16961_VCA02999	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N16961_VCA03001	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N16961_VCA03002	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N16961_VCA03011	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_VCA03014	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N16961_VCA03019	COG0494	nUDIX hydrolase
N16961_VCA03021	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_VCA03022	COG3040	lipid binding
N16961_VCA03026	COG3041	Addiction module toxin RelE StbE family
N16961_VCA03035	COG1619	proteins homologs of microcin C7 resistance protein MccF
N16961_VCA03044	COG0346	lactoylglutathione lyase activity
N16961_VCA03047	COG3040	lipid binding
N16961_VCA03049	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N16961_VCA03050	COG1280	lysine exporter protein (LysE YggA)
N16961_VCA03077	COG3549	Plasmid maintenance system killer
N16961_VCA03078	COG3093	addiction module antidote protein HigA
N16961_VCA03079	COG0384	phenazine biosynthesis protein PhzF
N16961_VCA03085	COG0346	lactoylglutathione lyase activity
N16961_VCA03088	COG3040	lipid binding
N16961_VCA03095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_VCA03109	COG1619	proteins homologs of microcin C7 resistance protein MccF
N16961_VCA03113	COG3040	lipid binding
N16961_VCA03124	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N16961_VCA03125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N16961_VCA03126	COG4977	sequence-specific DNA binding
N16961_VCA03137	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
N16961_VCA03138	COG2944	sequence-specific DNA binding
N16961_VCA03141	COG3039	Transposase
N16961_VCA03142	COG0110	maltose O-acetyltransferase activity
N16961_VCA03145	COG0346	lactoylglutathione lyase activity
N16961_VCA03161	COG1943	Transposase
N16961_VCA03171	COG0346	lactoylglutathione lyase activity
N16961_VCA03176	COG1328	CTP reductase activity
N16961_VCA03177	COG0602	queuosine metabolic process
N16961_VCA03179	COG0189	ligase activity
N16961_VCA03179	COG4067	protein conserved in archaea
N16961_VCA03180	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N16961_VCA03180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_VCA03180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_VCA03181	COG1105	Belongs to the carbohydrate kinase PfkB family
N16961_VCA03182	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_VCA03182	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_VCA03183	COG1609	Transcriptional regulator
N16961_VCA03184	COG0420	3'-5' exonuclease activity
N16961_VCA03185	COG0419	ATPase involved in DNA repair
N16961_VCA03186	COG0784	Response regulator, receiver
N16961_VCA03186	COG2205	protein histidine kinase activity
N16961_VCA03187	COG0156	8-amino-7-oxononanoate synthase activity
N16961_VCA03189	COG0038	chloride channel
N16961_VCA03190	COG0523	cobalamin synthesis protein
N16961_VCA03192	COG3158	transport of potassium into the cell
N16961_VCA03193	COG0674	pyruvate-flavodoxin oxidoreductase activity
N16961_VCA03193	COG1013	pyruvate-flavodoxin oxidoreductase activity
N16961_VCA03193	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N16961_VCA03193	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N16961_VCA03194	COG2205	protein histidine kinase activity
N16961_VCA03195	COG0745	RESPONSE REGULATOR receiver
N16961_VCA03196	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N16961_VCA03197	COG0586	Pfam SNARE associated Golgi protein
N16961_VCA03199	COG2200	EAL domain
N16961_VCA03201	COG3038	cytochrome b561
N16961_VCA03203	COG2116	formate transmembrane transporter activity
N16961_VCA03204	COG0583	DNA-binding transcription factor activity
N16961_VCA03206	COG3593	DNA synthesis involved in DNA repair
N16961_VCA03207	COG0737	Belongs to the 5'-nucleotidase family
N16961_VCA03211	COG2824	Alkylphosphonate utilization operon protein PhnA
N16961_VCA03221	COG3706	GGDEF domain
N16961_VCA03224	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N16961_VCA03225	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N16961_VCA03227	COG0745	RESPONSE REGULATOR receiver
N16961_VCA03231	COG0023	Translation Initiation Factor
N16961_VCA03233	COG1181	Belongs to the D-alanine--D-alanine ligase family
N16961_VCA03235	COG1042	CoA-binding domain protein
N16961_VCA03235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_VCA03235	COG0045	succinate-CoA ligase (ADP-forming) activity
N16961_VCA03236	COG0583	DNA-binding transcription factor activity
N16961_VCA03237	COG4771	TonB-dependent receptor
N16961_VCA03237	COG1629	transport
N16961_VCA03240	COG2050	protein possibly involved in aromatic compounds catabolism
N16961_VCA03244	COG0625	glutathione transferase activity
N16961_VCA03247	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N16961_VCA03248	COG4172	Belongs to the ABC transporter superfamily
N16961_VCA03249	COG4239	(ABC) transporter, permease
N16961_VCA03250	COG4174	ABC transporter (Permease)
N16961_VCA03251	COG4166	transmembrane transport
N16961_VCA03260	COG3842	ATPase activity
N16961_VCA03262	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N16961_VCA03264	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N16961_VCA03265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N16961_VCA03266	COG1011	Hydrolase
N16961_VCA03268	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
N16961_VCA03269	COG1970	mechanosensitive ion channel activity
N16961_VCA03270	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N16961_VCA03271	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_VCA03271	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_VCA03272	COG0302	gtp cyclohydrolase
N16961_VCA03274	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N16961_VCA03276	COG2897	thiosulfate sulfurtransferase activity
N16961_VCA03277	COG2390	Transcriptional regulator
N16961_VCA03278	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N16961_VCA03279	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N16961_VCA03284	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N16961_VCA03289	COG0583	DNA-binding transcription factor activity
N16961_VCA03290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N16961_VCA03291	COG0778	Nitroreductase
N16961_VCA03296	COG0640	Transcriptional regulator
N16961_VCA03298	COG0446	pyridine nucleotide-disulphide oxidoreductase
N16961_VCA03307	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_VCA03307	COG1263	PTS System
N16961_VCA03309	COG1621	beta-fructofuranosidase activity
N16961_VCA03310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_VCA03311	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N16961_VCA03313	COG2885	chlorophyll binding
N16961_VCA03314	COG0545	Peptidyl-prolyl cis-trans isomerase
N16961_VCA03315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N16961_VCA03316	COG0840	transmembrane signaling receptor activity
N16961_VCA03317	COG3069	C4-dicarboxylate transmembrane transporter activity
N16961_VCA03318	COG1760	l-serine dehydratase
N16961_VCA03323	COG1609	Transcriptional regulator
N16961_VCA03324	COG2197	response regulator
N16961_VCA03325	COG3850	Histidine kinase
N16961_VCA03326	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N16961_VCA03328	COG0243	molybdopterin cofactor binding
N16961_VCA03332	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N16961_VCA03333	COG2197	response regulator
N16961_VCA03334	COG3851	Histidine kinase
N16961_VCA03335	COG2271	Major facilitator Superfamily
N16961_VCA03336	COG1840	ABC-type Fe3 transport system, periplasmic component
N16961_VCA03338	COG3842	ATPase activity
N16961_VCA03339	COG3243	poly(R)-hydroxyalkanoic acid synthase
N16961_VCA03341	COG0183	Belongs to the thiolase family
N16961_VCA03343	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_VCA03344	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_VCA03347	COG3706	GGDEF domain
N16961_VCA03348	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N16961_VCA03350	COG1979	alcohol dehydrogenase
N16961_VCA03353	COG4191	Histidine kinase
N16961_VCA03354	COG1840	ABC-type Fe3 transport system, periplasmic component
N16961_VCA03355	COG2271	Major facilitator Superfamily
N16961_VCA03356	COG0469	pyruvate kinase activity
N16961_VCA03357	COG0784	Response regulator, receiver
N16961_VCA03357	COG2198	Histidine kinase
N16961_VCA03357	COG2205	protein histidine kinase activity
N16961_VCA03358	COG1879	ABC-type sugar transport system periplasmic component
N16961_VCA03359	COG1803	Methylglyoxal synthase
N16961_VCA03360	COG1335	isochorismatase
N16961_VCA03361	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N16961_VCA03364	COG0210	DNA helicase
N16961_VCA03365	COG1289	transmembrane transporter activity
N16961_VCA03371	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N16961_VCA03372	COG4149	molybdate abc transporter
N16961_VCA03373	COG0725	ABC transporter, periplasmic molybdate-binding protein
N16961_VCA03374	COG1492	cobalamin metabolic process
N16961_VCA03382	COG0784	Response regulator, receiver
N16961_VCA03382	COG5002	protein histidine kinase activity
N16961_VCA03383	COG1879	ABC-type sugar transport system periplasmic component
N16961_VCA03385	COG2827	Endonuclease containing a URI domain
N16961_VCA03391	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N16961_VCA03392	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N16961_VCA03395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N16961_VCA03396	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
N16961_VCA03397	COG0247	lactate metabolic process
N16961_VCA03398	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N16961_VCA03399	COG3118	belongs to the thioredoxin family
N16961_VCA03405	COG0583	DNA-binding transcription factor activity
N16961_VCA03406	COG4160	amino acid transport
N16961_VCA03407	COG4215	(ABC) transporter
N16961_VCA03408	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_VCA03409	COG1126	abc transporter atp-binding protein
N16961_VCA03411	COG2425	protein containing a von Willebrand factor type A (vWA) domain
N16961_VCA03413	COG0494	nUDIX hydrolase
N16961_VCA03414	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
N16961_VCA03416	COG1309	transcriptional regulator
N16961_VCA03417	COG0513	Belongs to the DEAD box helicase family
N16961_VCA03418	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
N16961_VCA03420	COG0814	amino acid
N16961_VCA03421	COG0840	transmembrane signaling receptor activity
N16961_VCA03422	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N16961_VCA03423	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N16961_VCA03425	COG1984	allophanate hydrolase subunit 2
N16961_VCA03428	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N16961_VCA03429	COG4181	ATPase activity
N16961_VCA03431	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N16961_VCA03432	COG1716	ATPase activity
N16961_VCA03432	COG5001	Diguanylate cyclase
N16961_VCA03434	COG0484	heat shock protein binding
N16961_VCA03443	COG0546	phosphoglycolate phosphatase activity
N16961_VCA03446	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_VCA03447	COG1368	sulfuric ester hydrolase activity
N16961_VCA03449	COG0513	Belongs to the DEAD box helicase family
N16961_VCA03450	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
N16961_VCA03452	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N16961_VCA03454	COG3046	protein related to deoxyribodipyrimidine photolyase
N16961_VCA03456	COG3397	chitin binding
N16961_VCA03457	COG3227	Zinc metalloprotease (Elastase)
N16961_VCA03459	COG0010	Belongs to the arginase family
N16961_VCA03460	COG1166	arginine decarboxylase activity
N16961_VCA03462	COG2239	Acts as a magnesium transporter
N16961_VCA03463	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N16961_VCA03464	COG0459	protein refolding
N16961_VCA03466	COG0527	aspartate kinase activity
N16961_VCA03467	COG0662	Cupin 2, conserved barrel domain protein
N16961_VCA03468	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N16961_VCA03469	COG0456	acetyltransferase
N16961_VCA03471	COG2154	pterin-4-alpha-carbinolamine dehydratase
N16961_VCA03472	COG3186	Phenylalanine-4-hydroxylase
N16961_VCA03473	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N16961_VCA03476	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N16961_VCA03477	COG0583	DNA-binding transcription factor activity
N16961_VCA03480	COG2171	N-acyltransferase activity
N16961_VCA03481	COG1253	flavin adenine dinucleotide binding
N16961_VCA03482	COG1765	OsmC-like protein
N16961_VCA03488	COG0531	amino acid
N16961_VCA03489	COG3706	GGDEF domain
N16961_VCA03491	COG3279	Response regulator of the LytR AlgR family
N16961_VCA03492	COG3275	phosphorelay sensor kinase activity
N16961_VCA03495	COG0577	efflux transmembrane transporter activity
N16961_VCA03495	COG1136	(ABC) transporter
N16961_VCA03496	COG1136	(ABC) transporter
N16961_VCA03498	COG4989	oxidoreductase activity
N16961_VCA03499	COG0366	Alpha amylase catalytic
N16961_VCA03500	COG2067	long-chain fatty acid transport protein
N16961_VCA03501	COG2267	carboxylic ester hydrolase activity
N16961_VCA03503	COG3227	Zinc metalloprotease (Elastase)
N16961_VCA03504	COG3047	cAMP biosynthetic process
N16961_VCA03506	COG1686	Belongs to the peptidase S11 family
N16961_VCA03507	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N16961_VCA03508	COG1271	oxidase subunit
N16961_VCA03509	COG1294	oxidase, subunit
N16961_VCA03512	COG3048	D-serine ammonia-lyase activity
N16961_VCA03513	COG0583	DNA-binding transcription factor activity
N16961_VCA03520	COG1063	alcohol dehydrogenase
N16961_VCA03523	COG0693	protein deglycase activity
N16961_VCA03526	COG0346	lactoylglutathione lyase activity
N16961_VCA03530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N16961_VCA03531	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N16961_VCA03532	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N16961_VCA03533	COG0363	glucosamine-6-phosphate deaminase activity
N16961_VCA03534	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N16961_VCA03539	COG1929	Belongs to the glycerate kinase type-1 family
N16961_VCA03540	COG2610	gluconate transmembrane transporter activity
N16961_VCA03541	COG3835	regulator
N16961_VCA03543	COG0748	coenzyme F420 binding
N16961_VCA03544	COG3721	Heme iron utilization protein
N16961_VCA03546	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N16961_VCA03547	COG0811	peptide transport
N16961_VCA03548	COG0848	biopolymer transport protein
N16961_VCA03549	COG4558	Periplasmic binding protein
N16961_VCA03550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_VCA03551	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N16961_VCA03558	COG3217	Mosc domain protein beta barrel domain protein
N16961_VCA03558	COG0633	Ferredoxin
N16961_VCA03558	COG3217	Mosc domain protein beta barrel domain protein
N16961_VCA03558	COG0633	Ferredoxin
N16961_VCA03559	COG0418	dihydroorotase activity
N16961_VCA03561	COG3152	Membrane
N16961_VCA03563	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N16961_VCA03564	COG2354	Protein conserved in bacteria
N16961_VCA03565	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N16961_VCA03567	COG1278	Cold shock
N16961_VCA03570	COG4753	response regulator
N16961_VCA03570	COG2207	Transcriptional regulator
N16961_VCA03572	COG3706	GGDEF domain
N16961_VCA03573	COG1349	DNA-binding transcription factor activity
N16961_VCA03577	COG3833	ABC-type maltose transport systems, permease component
N16961_VCA03578	COG1175	transmembrane transport
N16961_VCA03580	COG3842	ATPase activity
N16961_VCA03581	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_VCA03584	COG0393	Putative heavy-metal-binding
N16961_VCA03585	COG2197	response regulator
N16961_VCA03586	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N16961_VCA03587	COG0835	chemotaxis
N16961_VCA03587	COG0784	Response regulator, receiver
N16961_VCA03588	COG1846	Transcriptional regulator
N16961_VCA03589	COG3706	GGDEF domain
N16961_VCA03597	COG0583	DNA-binding transcription factor activity
N16961_VCA03598	COG5001	Diguanylate cyclase
N16961_VCA03600	COG1741	Belongs to the pirin family
N16961_VCA03601	COG3123	guanosine phosphorylase activity
N16961_VCA03603	COG2211	Major facilitator Superfamily
N16961_VCA03605	COG0840	transmembrane signaling receptor activity
N16961_VCA03606	COG1067	ATP-dependent peptidase activity
N16961_VCA03608	COG4172	Belongs to the ABC transporter superfamily
N16961_VCA03613	COG0583	DNA-binding transcription factor activity
N16961_VCA03614	COG1620	l-lactate permease
N16961_VCA03615	COG1304	FMN binding
N16961_VCA03617	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N16961_VCA03619	COG0840	transmembrane signaling receptor activity
N16961_VCA03621	COG0513	Belongs to the DEAD box helicase family
N16961_VCA03622	COG0583	DNA-binding transcription factor activity
N16961_VCA03624	COG1902	pentaerythritol trinitrate reductase activity
N16961_VCA03626	COG1132	(ABC) transporter
N16961_VCA03628	COG1902	pentaerythritol trinitrate reductase activity
N16961_VCA03630	COG1280	lysine exporter protein (LysE YggA)
N16961_VCA03631	COG2207	Transcriptional regulator
N16961_VCA03635	COG1846	Transcriptional regulator
N16961_VCA03636	COG1764	response to oxidative stress
N16961_VCA03637	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N16961_VCA03638	COG0697	spore germination
N16961_VCA03640	COG0700	Nucleoside recognition
N16961_VCA03641	COG3366	ferrous iron transmembrane transporter activity
N16961_VCA03642	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N16961_VCA03644	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N16961_VCA03645	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N16961_VCA03646	COG2259	Doxx family
N16961_VCA03651	COG0363	glucosamine-6-phosphate deaminase activity
N16961_VCA03654	COG4580	involved in the transport of maltose and maltodextrins
N16961_VCA03657	COG0840	transmembrane signaling receptor activity
N16961_VCA03660	COG0840	transmembrane signaling receptor activity
N16961_VCA03662	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N16961_VCA03663	COG1126	abc transporter atp-binding protein
N16961_VCA03665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_VCA03666	COG4597	amino acid ABC transporter
N16961_VCA03667	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N16961_VCA03668	COG0739	heme binding
N16961_VCA03671	COG2213	PTS system mannitol-specific
N16961_VCA03671	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_VCA03672	COG0246	Mannitol dehydrogenase
N16961_VCA03673	COG3722	fumarate hydratase activity
N16961_VCA03674	COG0673	inositol 2-dehydrogenase activity
N16961_VCA03680	COG2910	NAD(P)H-binding
N16961_VCA03682	COG0840	transmembrane signaling receptor activity
N16961_VCA03683	COG4221	oxidoreductase activity
N16961_VCA03685	COG1901	pseudouridine methyltransferase
N16961_VCA03686	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N16961_VCA03688	COG0531	amino acid
N16961_VCA03689	COG1982	Orn Lys Arg decarboxylase major
N16961_VCA03694	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N16961_VCA03699	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N16961_VCA03701	COG0259	pyridoxamine-phosphate oxidase activity
N16961_VCA03707	COG0745	RESPONSE REGULATOR receiver
N16961_VCA03711	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N16961_VCA03712	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N16961_VCA03713	COG0840	transmembrane signaling receptor activity
N16961_VCA03714	COG0835	chemotaxis
N16961_VCA03715	COG0835	chemotaxis
N16961_VCA03716	COG0643	Histidine kinase
N16961_VCA03716	COG2198	Histidine kinase
N16961_VCA03720	COG0601	transmembrane transport
N16961_VCA03721	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_VCA03723	COG2194	sulfuric ester hydrolase activity
N16961_VCA03724	COG0642	Histidine kinase
N16961_VCA03725	COG0745	RESPONSE REGULATOR receiver
N16961_VCA03731	COG1444	tRNA N-acetyltransferase activity
N16961_VCA03732	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine