locus-tag	class	description
IR04_00025	ENOG4105CDY	transcriptional regulatory protein
IR04_00030	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
IR04_00035	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_00040	ENOG4108YYI	Protein of unknown function (DUF2810)
IR04_00045	ENOG41061ZR	Transcriptional regulator
IR04_00050	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
IR04_00055	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
IR04_00060	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
IR04_00065	ENOG4108WC9	type VI secretion system effector, hcp1 family
IR04_00070	ENOG4105CS6	Rhs element vgr protein
IR04_00095	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
IR04_00105	ENOG4105C8P	)-transporter
IR04_00110	ENOG4108Q67	UPF0319 protein
IR04_00135	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_00155	ENOG4105EYK	Phosphatidylglycerophosphatase B
IR04_00160	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
IR04_00185	ENOG4105D6U	Sodium Glutamate Symporter
IR04_00190	ENOG4105YE1	PilZ domain
IR04_00205	ENOG4105EFX	secretion protein, HlyD family
IR04_00210	ENOG4105KK7	inner membrane protein YiaW
IR04_00215	ENOG4106TD9	Diguanylate cyclase
IR04_00230	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
IR04_00235	ENOG4107SEY	Conserved Protein
IR04_00245	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
IR04_00250	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
IR04_00265	ENOG4105CUG	Oligopeptidase b
IR04_00295	ENOG4105CVA	phosphate
IR04_00300	ENOG4105C8U	phosphate abc transporter
IR04_00305	ENOG4105E2Z	phosphate ABC transporter (Permease
IR04_00310	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
IR04_00315	ENOG4105BZU	Histidine kinase
IR04_00325	ENOG4105DWD	nucleoside recognition domain protein
IR04_00330	ENOG4105CHH	sulfate transporter
IR04_00340	ENOG4105DR5	peptidase
IR04_00345	ENOG4105BZU	Histidine kinase
IR04_00350	ENOG4105EQ2	LysR family Transcriptional regulator
IR04_00355	ENOG4105E5M	Multidrug resistance protein D
IR04_00360	ENOG4108Z4X	TRANSCRIPTIONal
IR04_00380	ENOG4105CK2	sodium dicarboxylate symporter
IR04_00425	ENOG4107RH7	Nicotinate phosphoribosyltransferase
IR04_00430	ENOG4105D9R	oxidoreductase
IR04_00440	ENOG4105BZU	Histidine kinase
IR04_00445	ENOG4107VXZ	Hydrolase
IR04_00455	ENOG4105D3G	Pseudouridine synthase
IR04_00515	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
IR04_00520	ENOG4108JUB	Transcriptional regulator
IR04_00545	ENOG4105CS6	Rhs element vgr protein
IR04_00560	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
IR04_00565	ENOG4105C2J	ABC transporter
IR04_00570	ENOG4105CNN	ABC, transporter
IR04_00575	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
IR04_00580	ENOG4108RVA	ribokinase
IR04_00585	ENOG4105ETE	Transcriptional regulator (LacI family
IR04_00590	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
IR04_00595	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
IR04_00600	ENOG4108I5U	Uridine phosphorylase
IR04_00610	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
IR04_00615	ENOG4105CXY	transporter
IR04_00630	ENOG4105CQZ	Histidine kinase
IR04_00635	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_00655	ENOG4105D5U	fad dependent oxidoreductase
IR04_00665	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
IR04_00675	ENOG4105KJM	monovalent cation h antiporter subunit g
IR04_00680	ENOG41080TA	Multiple resistance and ph regulation protein f
IR04_00685	ENOG4105SC1	monovalent cation H antiporter subunit E
IR04_00690	ENOG4108JPZ	Monovalent cation H antiporter subunit D
IR04_00695	ENOG4105MKQ	Monovalent cation H antiporter subunit C
IR04_00700	ENOG4105D65	subunit l
IR04_00710	ENOG4105Q9Y	Universal stress protein
IR04_00715	ENOG4105CIC	tryptophan-specific transport protein
IR04_00720	ENOG4105C0F	tryptophanase EC 4.1.99.1
IR04_00725	ENOG4105VRT	cytoplasmic protein
IR04_00740	ENOG4105BZU	Histidine kinase
IR04_00745	ENOG4105VEQ	Cold shock protein
IR04_00780	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
IR04_00785	ENOG41069D7	Methyl-accepting chemotaxis
IR04_00800	ENOG4105D9N	nucleoside
IR04_00805	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
IR04_00815	ENOG4108JUA	Transcriptional regulator
IR04_00820	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
IR04_00825	ENOG4105VEQ	Cold shock protein
IR04_00855	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
IR04_00860	ENOG4105C5I	Dehydrogenase
IR04_00880	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
IR04_00905	ENOG4108RS6	transposase
IR04_00910	ENOG4105C1J	atp-dependent rna helicase
IR04_00915	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
IR04_00920	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
IR04_00925	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
IR04_00930	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
IR04_00935	ENOG4105BZU	Histidine kinase
IR04_00945	ENOG4107S6Z	Na H antiporter
IR04_00950	ENOG4105E5M	Multidrug resistance protein D
IR04_00960	ENOG4105BZU	Histidine kinase
IR04_00965	ENOG4105KUU	lipolytic protein G-D-S-L family
IR04_00970	ENOG4106M3D	hemolysin
IR04_00975	ENOG4108N3W	hemolysin secretion protein
IR04_00980	ENOG4107IFA	Lipase (EC 3.1.1.3)
IR04_00990	ENOG4107G87	m6 family metalloprotease domain protein
IR04_01010	ENOG4105DHS	permease protein
IR04_01015	ENOG4105CM4	permease protein
IR04_01020	ENOG4108IPW	abc transporter atp-binding protein
IR04_01040	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
IR04_01060	ENOG4105ETX	regulatoR
IR04_01075	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
IR04_01085	ENOG410667J	hydrolase
IR04_01115	ENOG4105DS1	cytochrome b561
IR04_01145	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
IR04_01150	ENOG4105BZU	Histidine kinase
IR04_01180	ENOG4107QVI	Methyltransferase, type 11
IR04_01195	ENOG4105C2C	drug resistance transporter, Bcr CflA
IR04_01200	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_01210	ENOG4105DZ1	carboxypeptidase
IR04_01230	ENOG4108RS6	transposase
IR04_01235	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IR04_01240	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
IR04_01245	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
IR04_01255	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
IR04_01265	ENOG4105F2I	Transposase
IR04_01290	ENOG4105C22	threonyL-tRNA synthetase
IR04_01295	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
IR04_01300	ENOG41082NX	50s ribosomal protein l35
IR04_01305	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
IR04_01340	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
IR04_01380	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
IR04_01410	ENOG4105D9U	N-acetyltransferase
IR04_01415	ENOG4105QNF	Outer membrane lipoprotein
IR04_01440	ENOG4105VXN	addiction module toxin, RelE StbE family
IR04_01450	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
IR04_01505	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
IR04_01520	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
IR04_01550	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
IR04_01565	ENOG4105QNF	Outer membrane lipoprotein
IR04_01580	ENOG4105YGK	Pfam:UPF0157
IR04_01585	ENOG4105N14	lysine exporter protein LysE YggA
IR04_01755	ENOG41080ET	plasmid maintenance system killer protein
IR04_01760	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
IR04_01775	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
IR04_01795	ENOG4105QNF	Outer membrane lipoprotein
IR04_01890	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
IR04_01905	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
IR04_01910	ENOG4105W08	virulence gene repressor rsal
IR04_01925	ENOG4105F2I	Transposase
IR04_01945	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
IR04_02030	ENOG4108RS6	transposase
IR04_02090	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
IR04_02115	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
IR04_02120	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
IR04_02125	ENOG4105CGF	Aromatic amino acid aminotransferase
IR04_02130	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
IR04_02140	ENOG4105DM4	PTS System
IR04_02145	ENOG4105DE4	1-phosphofructokinase
IR04_02150	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
IR04_02155	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
IR04_02160	ENOG4107RFY	SbcCD D subunit
IR04_02165	ENOG4105EYH	Exonuclease
IR04_02170	ENOG4108MGY	Histidine kinase
IR04_02175	ENOG4107KBT	8-Amino-7-oxononanoate synthase
IR04_02185	ENOG4105CMQ	Chloride channel
IR04_02190	ENOG4105CKI	cobalamin synthesis protein
IR04_02195	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
IR04_02200	ENOG4105DFH	Transport of potassium into the cell (By similarity)
IR04_02205	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
IR04_02210	ENOG4105C08	Histidine kinase
IR04_02215	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
IR04_02220	ENOG410607N	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity)
IR04_02225	ENOG4108RHM	integral membrane protein
IR04_02235	ENOG4105EPM	Diguanylate phosphodiesterase
IR04_02245	ENOG4105DS1	cytochrome b561
IR04_02265	ENOG4105DUM	transcriptional regulator, lysR family
IR04_02270	ENOG4108UQ5	membrane protein YcdZ
IR04_02275	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
IR04_02280	ENOG4105CGH	5'-nucleotidase
IR04_02285	ENOG4105DU1	integral membrane protein, terc
IR04_02295	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
IR04_02335	ENOG4105BZU	Histidine kinase
IR04_02345	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
IR04_02355	ENOG4105BZU	Histidine kinase
IR04_02370	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
IR04_02375	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
IR04_02385	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
IR04_02410	ENOG4108ZJT	translation initiation factor, Sui1
IR04_02420	ENOG4105CPF	Cell wall formation (By similarity)
IR04_02430	ENOG4105CD5	CoA-binding domain protein
IR04_02435	ENOG4105CWB	LysR family transcriptional Regulator
IR04_02455	ENOG4105KA0	thioesterase Superfamily protein
IR04_02475	ENOG4105CYM	Glutathione S-transferase
IR04_02490	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
IR04_02495	ENOG4108JQ5	ABC transporter
IR04_02500	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
IR04_02505	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
IR04_02510	ENOG4105E43	Extracellular solute-binding protein, family 5
IR04_02535	ENOG4105DUX	Transporter
IR04_02550	ENOG4107RCV	ABC transporter, permease
IR04_02565	ENOG4107STF	Involved in phosphonate degradation (By similarity)
IR04_02570	ENOG4108JPW	Aminotransferase
IR04_02575	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
IR04_02580	ENOG4105NXH	GreA GreB family elongation factor
IR04_02585	ENOG4105PAD	Hydrolase
IR04_02595	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
IR04_02600	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
IR04_02605	ENOG4105CKU	formyltetrahydrofolate synthetase
IR04_02610	ENOG4105E0X	reductase
IR04_02615	ENOG4105EUJ	GTP cyclohydrolase i
IR04_02620	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
IR04_02625	ENOG4105D06	uba thif-type nad fad binding protein
IR04_02635	ENOG4105KHC	sulfurtransferase
IR04_02650	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
IR04_02655	ENOG4105CV1	Transketolase (EC 2.2.1.1)
IR04_02680	ENOG4108M3J	Dehydrogenase
IR04_02695	ENOG4105RA2	Membrane
IR04_02705	ENOG4105ETT	transcriptional Regulator, LysR family
IR04_02710	ENOG41067V3	Antibiotic biosynthesis monooxygenase
IR04_02740	ENOG41080HT	Transcriptional regulator, arsr family
IR04_02750	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
IR04_02795	ENOG4105C5Y	PTS System
IR04_02800	ENOG4105ETE	Transcriptional regulator (LacI family
IR04_02805	ENOG4107R3K	hydrolase
IR04_02810	ENOG4105D7K	pfkb domain protein
IR04_02815	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
IR04_02820	ENOG4108NVR	Methyl-accepting chemotaxis
IR04_02825	ENOG4108ZG0	Ompa motb domain protein
IR04_02830	ENOG4108V1T	peptidylprolyl cis-trans isomerase
IR04_02835	ENOG4107VXZ	Hydrolase
IR04_02840	ENOG4108N3W	hemolysin secretion protein
IR04_02845	ENOG4105CEE	C4-dicarboxylate transporter
IR04_02850	ENOG4105EJQ	L-serine dehydratase
IR04_02870	ENOG4105ETE	Transcriptional regulator (LacI family
IR04_02875	ENOG4105WH1	Two component transcriptional regulator luxr family
IR04_02880	ENOG4105BZU	Histidine kinase
IR04_02895	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
IR04_02915	ENOG4105DHT	Metal Dependent Phosphohydrolase
IR04_02920	ENOG4108KX4	response regulator
IR04_02925	ENOG4105BZU	Histidine kinase
IR04_02930	ENOG4105CXY	transporter
IR04_02935	ENOG4105C4Y	ABC transporter
IR04_02940	ENOG4107RCV	ABC transporter, permease
IR04_02945	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
IR04_02950	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
IR04_02960	ENOG4105CHU	acetyl-coa acetyltransferase
IR04_02970	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
IR04_02975	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
IR04_02990	ENOG4105BZU	Histidine kinase
IR04_02995	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
IR04_03005	ENOG4108I6A	alcohol dehydrogenase
IR04_03015	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
IR04_03025	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
IR04_03030	ENOG4105CXY	transporter
IR04_03035	ENOG4105CA9	Pyruvate kinase
IR04_03040	ENOG4105BZU	Histidine kinase
IR04_03045	ENOG4108SV3	Tmao reductase system periplasmic protein tort
IR04_03050	ENOG4108Z5K	methylglyoxal synthase
IR04_03055	ENOG4108RWI	nicotinamidase
IR04_03060	ENOG41080IJ	Diacylglycerol kinase
IR04_03075	ENOG41088T4	Helicase IV
IR04_03080	ENOG4105EM2	membrane
IR04_03110	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
IR04_03115	ENOG4105E0C	molybdate abc transporter
IR04_03120	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
IR04_03125	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
IR04_03170	ENOG4105BZU	Histidine kinase
IR04_03175	ENOG4108QGH	periplasmic
IR04_03215	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
IR04_03220	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
IR04_03230	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
IR04_03235	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
IR04_03240	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
IR04_03245	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
IR04_03250	ENOG4105K63	Thioredoxin
IR04_03280	ENOG4105DUM	transcriptional regulator, lysR family
IR04_03285	ENOG4105DMR	ABC, transporter
IR04_03290	ENOG4105GBT	ABC transporter
IR04_03295	ENOG4106PMH	Extracellular solute-binding protein family 3
IR04_03300	ENOG4105E5Z	arginine transporter ATP-binding subunit
IR04_03310	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
IR04_03320	ENOG4108YZ4	nudix hydrolase
IR04_03325	ENOG4105C5W	Aldolase
IR04_03330	ENOG4106RE7	Cytochrome
IR04_03335	ENOG4108IG5	Transcriptional regulator
IR04_03340	ENOG4105C1J	atp-dependent rna helicase
IR04_03345	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
IR04_03355	ENOG4105E0U	tyrosine-specific transport protein
IR04_03360	ENOG4108N3W	hemolysin secretion protein
IR04_03365	ENOG4105CMR	udp-glucose 4-epimerase
IR04_03370	ENOG4105E7W	lamb ycsf family protein
IR04_03380	ENOG4107R7A	Allophanate hydrolase subunit 2
IR04_03390	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
IR04_03395	ENOG4105CV6	ABC transporter, permease
IR04_03400	ENOG4108I0Y	(ABC) transporter
IR04_03410	ENOG4105RKW	reductase (By
IR04_03430	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
IR04_03475	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
IR04_03490	ENOG4107RE1	Inosine-guanosine kinase
IR04_03495	ENOG4105E0M	Sulfatase
IR04_03505	ENOG4105C1J	atp-dependent rna helicase
IR04_03510	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
IR04_03520	ENOG4105CVA	phosphate
IR04_03530	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
IR04_03535	ENOG4108M1A	Chitin-binding protein
IR04_03540	ENOG4105D4Y	metalloprotease
IR04_03550	ENOG4105CYW	agmatinase
IR04_03555	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
IR04_03565	ENOG4105CJW	magnesium transporter
IR04_03570	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
IR04_03575	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
IR04_03585	ENOG4105CZK	Aspartate kinase
IR04_03590	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
IR04_03595	ENOG4108JPW	Aminotransferase
IR04_03600	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
IR04_03605	ENOG41090A4	Pterin carbinolamine dehydratase
IR04_03610	ENOG4105MIR	Phenylalanine 4-monooxygenase
IR04_03615	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
IR04_03630	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
IR04_03635	ENOG4105EGI	Transcriptional regulator
IR04_03650	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
IR04_03655	ENOG4105C37	(CBS) domain
IR04_03660	ENOG4108UKZ	OsmC family
IR04_03665	ENOG4107YWA	deoxycytidylate deaminase
IR04_03685	ENOG4105DVH	amino acid
IR04_03690	ENOG4106TD9	Diguanylate cyclase
IR04_03700	ENOG4108VAC	response regulator
IR04_03705	ENOG4108HRK	Histidine kinase
IR04_03720	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
IR04_03725	ENOG4105C19	ABC transporter
IR04_03740	ENOG4107RGM	aldo keto reductase
IR04_03745	ENOG4107T9C	Alpha amylase catalytic region
IR04_03760	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
IR04_03765	ENOG4108M0H	Extracellular lipase
IR04_03770	ENOG4107SDU	Methyl-accepting chemotaxis
IR04_03775	ENOG4105D4Y	metalloprotease
IR04_03780	ENOG4105EIF	outer membrane protein W
IR04_03790	ENOG41061WM	D-Alanyl-D-Alanine
IR04_03795	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
IR04_03800	ENOG4105C4M	(Ubiquinol oxidase) subunit I
IR04_03805	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
IR04_03815	ENOG4105BZC	d-serine deaminase
IR04_03820	ENOG4105W8I	Transcriptional regulator
IR04_03860	ENOG4105CPQ	Dehydrogenase
IR04_03865	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
IR04_03870	ENOG4105TMR	Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity)
IR04_03875	ENOG4105TMR	Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity)
IR04_03885	ENOG4105EXG	Transcriptional regulator
IR04_03890	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
IR04_03910	ENOG4107SSZ	Phosphatase
IR04_03915	ENOG4105DHT	Metal Dependent Phosphohydrolase
IR04_03920	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
IR04_03925	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
IR04_03930	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
IR04_03955	ENOG4105BZW	Glycerate kinase
IR04_03960	ENOG4105C6Z	Gluconate
IR04_03965	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
IR04_03970	ENOG4108NVR	Methyl-accepting chemotaxis
IR04_03975	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
IR04_03980	ENOG41090JE	Utilization Protein
IR04_03985	ENOG4105D4P	Coproporphyrinogen iii oxidase
IR04_03990	ENOG4105WQ5	TonB family
IR04_03995	ENOG41090AP	transport protein
IR04_04000	ENOG4106GFD	transport protein
IR04_04005	ENOG4107R4I	Periplasmic binding protein
IR04_04010	ENOG4105EHG	Permease protein
IR04_04015	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
IR04_04045	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_04050	ENOG4105QVC	MOSC domain-containing protein
IR04_04050	ENOG4105QVC	MOSC domain-containing protein
IR04_04055	ENOG4105EKE	dihydroorotase
IR04_04065	ENOG4105KAF	membrAne
IR04_04075	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
IR04_04080	ENOG4105CKW	Inner membrane protein yedI
IR04_04085	ENOG4108ESY	Metal dependent phosphohydrolase
IR04_04090	ENOG4105VEQ	Cold shock protein
IR04_04115	ENOG4105BZU	Histidine kinase
IR04_04120	ENOG4105E98	transcriptional regulator DeoR family
IR04_04135	ENOG4105EG2	ABC transporter, permease
IR04_04140	ENOG4105D56	permease protein
IR04_04145	ENOG4107FKK	extracellular solute-binding protein family 1
IR04_04150	ENOG4108IJ9	(ABC) transporter
IR04_04155	ENOG4108HK0	-acetyltransferase
IR04_04170	ENOG4105K8R	UPF0145 protein
IR04_04175	ENOG41086KC	Transcriptional regulator
IR04_04180	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
IR04_04185	ENOG4107R88	Chemotaxis protein (CheV)
IR04_04190	ENOG4105K56	Transcriptional regulator
IR04_04195	ENOG4106TD9	Diguanylate cyclase
IR04_04210	ENOG4105BZU	Histidine kinase
IR04_04230	ENOG4105ETT	transcriptional Regulator, LysR family
IR04_04235	ENOG4108K0B	C-di-gmp phosphodiesterase
IR04_04250	ENOG4105EUB	pirin domain protein
IR04_04255	ENOG4105NBK	UPF0345 protein
IR04_04265	ENOG4105E5W	Transporter
IR04_04275	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_04280	ENOG4105DAN	ATP-dependent protease
IR04_04290	ENOG4108JQ5	ABC transporter
IR04_04295	ENOG4105E89	ABC transporter
IR04_04300	ENOG4107SDU	Methyl-accepting chemotaxis
IR04_04315	ENOG4105CC0	LysR family Transcriptional regulator
IR04_04320	ENOG4105DAA	L-lactate
IR04_04325	ENOG4105DMF	Dehydrogenase
IR04_04335	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
IR04_04350	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
IR04_04360	ENOG4105C1J	atp-dependent rna helicase
IR04_04365	ENOG4105CR8	Transcriptional regulator
IR04_04375	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
IR04_04385	ENOG4105BZ1	(ABC) transporter
IR04_04430	ENOG4105K56	Transcriptional regulator
IR04_04435	ENOG4108ZHJ	Organic hydroperoxide resistance protein
IR04_04445	ENOG4108SXK	Transporter Drug Metabolite Exporter family
IR04_04450	ENOG4105VW4	glutaredoxin 3
IR04_04455	ENOG4108P2H	Inner membrane protein YjiG
IR04_04460	ENOG41074DU	domain protein
IR04_04465	ENOG4105DN9	Na H antiporter
IR04_04475	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
IR04_04480	ENOG4105D03	DNA-3-methyladenine glycosylase II
IR04_04485	ENOG4108VGI	doxx family
IR04_04510	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
IR04_04520	ENOG4107W52	maltose operon periplasmic protein
IR04_04525	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
IR04_04540	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_04555	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_04565	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
IR04_04570	ENOG4105CDA	abc transporter atp-binding protein
IR04_04580	ENOG4106TNF	Periplasmic binding protein
IR04_04585	ENOG4105EZ7	amino acid ABC transporter
IR04_04590	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
IR04_04600	ENOG4105DR5	peptidase
IR04_04610	ENOG4105CTS	PTS system mannitol-specific
IR04_04615	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
IR04_04620	ENOG4105E61	Mannitol repressor protein
IR04_04625	ENOG4105EP9	oxidoreductase
IR04_04655	ENOG4108RYK	Nad-dependent epimerase dehydratase
IR04_04660	ENOG4105JQN	Transcriptional regulator
IR04_04665	ENOG41069D7	Methyl-accepting chemotaxis
IR04_04670	ENOG4105EMU	Dehydrogenase
IR04_04675	ENOG4105JQN	Transcriptional regulator
IR04_04685	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
IR04_04695	ENOG4105D5Q	Arginine ornithine antiporter
IR04_04700	ENOG4105CXN	decarboxylase
IR04_04705	ENOG4107RGH	Aldehyde dehydrogenase
IR04_04710	ENOG4105EW9	transcriptional regulator AsnC family
IR04_04715	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_04725	ENOG4105CK7	Sodium proline symporter
IR04_04735	ENOG4105C26	Dehydrogenase
IR04_04750	ENOG4105E6M	Sulphatase-modifying factor protein
IR04_04765	ENOG4107QZV	Type I secretion membrane fusion protein
IR04_04780	ENOG4108JJA	ABC, transporter
IR04_04790	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
IR04_04800	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_04805	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
IR04_04810	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
IR04_04815	ENOG4105BZU	Histidine kinase
IR04_04820	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_04825	ENOG4108V3W	Chemotaxis protein, CheW
IR04_04830	ENOG4108V3W	Chemotaxis protein, CheW
IR04_04835	ENOG4105CBS	Chea signal transduction histidine kinase
IR04_04840	ENOG4108VYJ	response regulator receiver protein
IR04_04860	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
IR04_04865	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
IR04_04875	ENOG4105DIJ	Phosphoethanolamine transferase
IR04_04880	ENOG4105DHQ	Histidine kinase
IR04_04885	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
IR04_04915	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
IR04_04920	ENOG4107RUE	extracellular solute-binding protein family 1
IR04_04925	ENOG4106RMF	ParB family
IR04_04935	ENOG4105QTB	Flavodoxin
IR04_04940	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
IR04_04945	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
IR04_04950	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
IR04_04965	ENOG4105E5Q	amino acid AbC transporter
IR04_04970	ENOG4105EAB	amino acid AbC transporter
IR04_04975	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
IR04_04980	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
IR04_04985	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
IR04_04990	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IR04_05005	ENOG4108ZNX	Heat shock protein
IR04_05010	ENOG4105JKW	Valine--pyruvate aminotransferase
IR04_05015	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
IR04_05020	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
IR04_05035	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
IR04_05045	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
IR04_05050	ENOG4105C7B	Threonine dehydratase
IR04_05055	ENOG4105C01	Dihydroxy-acid dehydratase
IR04_05060	ENOG4105CM2	brancheD-chain amino acid aminotransferase
IR04_05075	ENOG4105C0P	Mg chelatase subunit ChlI
IR04_05080	ENOG4106HNH	Acyl-transferase
IR04_05085	ENOG4108Z33	Thiol disulfide Interchange Protein
IR04_05100	ENOG4105PC1	Conserved Protein
IR04_05110	ENOG4108N23	SpoOM-related protein
IR04_05115	ENOG4108UT2	hemolysin iii
IR04_05125	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
IR04_05130	ENOG4105C1A	potassium transporter peripheral membrane
IR04_05135	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
IR04_05140	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
IR04_05145	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
IR04_05150	ENOG4108WZM	domain protein
IR04_05155	ENOG4105C79	DNA protecting protein DprA
IR04_05160	ENOG4108RPN	Protein smg homolog
IR04_05165	ENOG4108WI1	Dna topoisomerase
IR04_05170	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
IR04_05175	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
IR04_05180	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
IR04_05185	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
IR04_05190	ENOG4105E2X	shikimate dehydrogenase
IR04_05200	ENOG4108Z0R	Transferase
IR04_05240	ENOG4105WMR	Protein CrcB homolog
IR04_05245	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
IR04_05255	ENOG4105D06	uba thif-type nad fad binding protein
IR04_05260	ENOG4105WHD	thiamine biosynthesis protein ThiS
IR04_05265	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
IR04_05270	ENOG4105D41	biosynthesis protein thiH
IR04_05275	ENOG4105DC7	peptidase M24
IR04_05275	ENOG4105DC7	peptidase M24
IR04_05285	ENOG4105CNH	Multidrug resistance protein MdtL
IR04_05295	ENOG4108VVK	transcriptional Regulator, AsnC
IR04_05300	ENOG4105BZU	Histidine kinase
IR04_05305	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
IR04_05315	ENOG4105EMK	carboxylate amino acid amine transporter
IR04_05320	ENOG4108M6U	Universal stress protein A
IR04_05325	ENOG41090A1	ferritin
IR04_05330	ENOG4108V6B	universal stress protein B
IR04_05335	ENOG4105CBX	hi0933 family
IR04_05345	ENOG4105CGY	Dna recombination protein
IR04_05350	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
IR04_05355	ENOG4105JC1	sterol-binding domain protein
IR04_05360	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
IR04_05365	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
IR04_05370	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
IR04_05375	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
IR04_05380	ENOG4105CA0	peroxidase
IR04_05385	ENOG4107R73	Mate efflux family protein
IR04_05395	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
IR04_05400	ENOG4105E55	glycerol-3-phosphate acyltransferase
IR04_05405	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
IR04_05410	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
IR04_05415	ENOG4105X6C	Flagellar basal body-associated protein FliL
IR04_05420	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_05435	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
IR04_05440	ENOG4105F8V	Hydrolase, tatD family
IR04_05445	ENOG4105D52	delta-aminolevulinic acid dehydratase
IR04_05455	ENOG4105C2M	dna polymerase I
IR04_05460	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
IR04_05475	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
IR04_05480	ENOG4105XCT	Protein of unknown function (DUF2489)
IR04_05485	ENOG4105D4P	Coproporphyrinogen iii oxidase
IR04_05490	ENOG410601J	HemY protein
IR04_05495	ENOG4105ECF	c-methyltransferase
IR04_05500	ENOG41076E6	Uroporphyrinogen-III Synthase
IR04_05505	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
IR04_05515	ENOG4107T0K	Adenylate cyclase
IR04_05520	ENOG4105XQ6	frataxin-like protein
IR04_05530	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
IR04_05535	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
IR04_05540	ENOG4105CT0	Protein of unknown function, DUF484
IR04_05545	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
IR04_05550	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
IR04_05555	ENOG4105BZU	Histidine kinase
IR04_05570	ENOG4105DQF	Hydrolase
IR04_05575	ENOG4108EUD	Lysophospholipase
IR04_05580	ENOG410829K	Lysine exporter protein (Lyse ygga)
IR04_05585	ENOG4105D58	Diguanylate phosphodiesterase
IR04_05590	ENOG4108RMU	ferritin dps family protein
IR04_05625	ENOG4106H78	methyltransferase
IR04_05630	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
IR04_05635	ENOG4105CAK	Cell division ATP-binding protein ftsE
IR04_05640	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
IR04_05645	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
IR04_05650	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
IR04_05665	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
IR04_05670	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
IR04_05675	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
IR04_05680	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
IR04_05715	ENOG4105EMY	transcriptional regulator
IR04_05720	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
IR04_05725	ENOG4105W0Z	cytoplasmic protein
IR04_05730	ENOG4105BZS	acriflavin resistance protein
IR04_05735	ENOG410624X	efflux transporter, rnd family, mfp subunit
IR04_05740	ENOG4105Y7M	Transcriptional regulator, TetR family
IR04_05745	ENOG4105C4R	Atp-dependent dna helicase
IR04_05750	ENOG4105MPD	Cytochrome
IR04_05790	ENOG4105DEF	Extracellular solute-binding protein, family 5
IR04_05795	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
IR04_05800	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
IR04_05810	ENOG4108UK2	deaminase
IR04_05840	ENOG4108ZXE	
IR04_05880	ENOG4105D6S	protein involved in catabolism of external DNA
IR04_05885	ENOG4105DGW	oligopeptidase A
IR04_05890	ENOG4105C4R	Atp-dependent dna helicase
IR04_05900	ENOG4108DMH	HTH_ARAC
IR04_05910	ENOG4105FR1	rard protein
IR04_05915	ENOG4105C9U	ATP-dependent DNA helicase RecQ
IR04_05930	ENOG4105BZ1	(ABC) transporter
IR04_05935	ENOG4105E0K	tonB-dependent siderophore receptor
IR04_05940	ENOG4105E0A	ABC, transporter
IR04_05945	ENOG4105J76	Periplasmic binding protein
IR04_05950	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
IR04_05955	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
IR04_05960	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR04_05965	ENOG4105C5Y	PTS System
IR04_05975	ENOG4105DSJ	YicC domain protein
IR04_05985	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
IR04_05990	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
IR04_05995	ENOG4105D1S	lipid A biosynthesis
IR04_06000	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
IR04_06005	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
IR04_06010	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_06020	ENOG4105KDC	50s ribosomal protein l28
IR04_06025	ENOG4105W0E	50S ribosomal protein L33
IR04_06035	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
IR04_06040	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
IR04_06045	ENOG4105M5K	heptosyltransferase
IR04_06050	ENOG4106WTF	Glycosyl transferase, family 2
IR04_06055	ENOG4105DKP	glycosyl transferase, family 9
IR04_06060	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
IR04_06090	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
IR04_06095	ENOG4108ST3	glycosyltransferase
IR04_06105	ENOG4105XA0	heptosyltransferase ii
IR04_06120	ENOG4107T94	Endo-14-beta-xylanase
IR04_06125	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
IR04_06130	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
IR04_06135	ENOG4107QKV	phosphomannomutase
IR04_06140	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
IR04_06145	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
IR04_06160	ENOG4105EY8	ABC transporter
IR04_06170	ENOG4105CEY	Amp-dependent synthetase and ligase
IR04_06175	ENOG4108EKI	Dehydrogenase
IR04_06185	ENOG4108UT6	Transferase hexapeptide repeat containing protein
IR04_06190	ENOG410600T	transposase
IR04_06220	ENOG4105D3Q	Sugar transferase
IR04_06225	ENOG4105CY0	Metallo-Beta-Lactamase
IR04_06230	ENOG4105CUY	Mechanosensitive ion channel
IR04_06235	ENOG4108RG0	uracil-dna glycosylase
IR04_06240	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
IR04_06245	ENOG4105R2J	Conserved Protein
IR04_06250	ENOG4105EIP	mannose-6-phosphate isomerase
IR04_06255	ENOG4105DKQ	ROK family
IR04_06265	ENOG4105K70	DNA-binding protein
IR04_06275	ENOG4105C12	Phosphoribosylglycinamide synthetase
IR04_06280	ENOG4105DC1	bifunctional purine biosynthesis protein purh
IR04_06290	ENOG4105W1Y	Transcriptional regulator
IR04_06295	ENOG4108M3R	transcriptional activator CadC
IR04_06300	ENOG4105D5Q	Arginine ornithine antiporter
IR04_06305	ENOG4105CXN	decarboxylase
IR04_06310	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_06325	ENOG4105E0K	tonB-dependent siderophore receptor
IR04_06330	ENOG4108UHU	Aldolase
IR04_06335	ENOG4105C6Z	Gluconate
IR04_06340	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
IR04_06345	ENOG4105C01	Dihydroxy-acid dehydratase
IR04_06350	ENOG4105DIQ	Transcriptional regulator
IR04_06355	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
IR04_06360	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
IR04_06365	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
IR04_06370	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
IR04_06375	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
IR04_06380	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
IR04_06385	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
IR04_06400	ENOG4105D8G	Major Facilitator superfamily
IR04_06405	ENOG4105BZU	Histidine kinase
IR04_06410	ENOG4105C9X	ppx gppa phosphatase
IR04_06415	ENOG4105C1J	atp-dependent rna helicase
IR04_06420	ENOG4105K63	Thioredoxin
IR04_06425	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
IR04_06435	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
IR04_06445	ENOG4107QK7	reductase
IR04_06480	ENOG4105JIM	Phosphatidylserine synthase
IR04_06490	ENOG4105D4A	Cell wall formation (By similarity)
IR04_06495	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
IR04_06500	ENOG4105CS9	pantothenic acid kinase
IR04_06525	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
IR04_06530	ENOG4105PM1	preprotein translocase subunit SecE
IR04_06535	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
IR04_06540	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
IR04_06545	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
IR04_06550	ENOG4108VZM	50s ribosomal protein L10
IR04_06555	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
IR04_06560	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IR04_06565	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IR04_06570	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
IR04_06575	ENOG4105E09	nadh pyrophosphatase
IR04_06580	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
IR04_06585	ENOG41062JF	Transcriptional regulator
IR04_06595	ENOG41063SB	peptidase
IR04_06600	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
IR04_06610	ENOG4105C8P	)-transporter
IR04_06615	ENOG4105DJ4	phosphatidylserine decarboxylase
IR04_06620	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
IR04_06625	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
IR04_06675	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
IR04_06680	ENOG4105K8N	protein family UPF0079, ATPase
IR04_06685	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
IR04_06690	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
IR04_06695	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
IR04_06700	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
IR04_06705	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
IR04_06710	ENOG4107QJR	hflk protein
IR04_06715	ENOG4105EPW	hflc protein
IR04_06725	ENOG41069P5	Protein slyX homolog
IR04_06735	ENOG4108V1T	peptidylprolyl cis-trans isomerase
IR04_06740	ENOG4105WWK	YheO domain protein
IR04_06745	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
IR04_06750	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
IR04_06760	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
IR04_06765	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
IR04_06770	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
IR04_06775	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
IR04_06780	ENOG4105W53	bacterioferritin-associated ferredoxin
IR04_06785	ENOG4108UQY	Iron-storage protein
IR04_06790	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
IR04_06795	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
IR04_06800	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
IR04_06805	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
IR04_06815	ENOG4105CDU	Replicative dna helicase
IR04_06820	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
IR04_06825	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
IR04_06830	ENOG4107QP8	phosphohexose isomerase
IR04_06845	ENOG4105MYN	Zinc uptake regulation protein
IR04_06850	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
IR04_06855	ENOG4105P4Z	Phage shock protein G
IR04_06870	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
IR04_06875	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
IR04_06880	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
IR04_06915	ENOG4105EEQ	Na H antiporter
IR04_06920	ENOG4105C3R	Methionine synthase
IR04_06925	ENOG4105CFH	Aspartokinase
IR04_06930	ENOG4105C5R	Aminotransferase
IR04_06940	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
IR04_06950	ENOG41086KC	Transcriptional regulator
IR04_06955	ENOG4108UUM	single-stranded DNA-binding protein
IR04_06960	ENOG41062P1	Diguanylate cyclase phosphodiesterase
IR04_06980	ENOG4105E4G	Type IV pilus
IR04_06995	ENOG4107QHF	type ii secretion system protein e
IR04_07000	ENOG4105D7Q	type ii secretion system
IR04_07010	ENOG4105X0D	Fimbrial protein
IR04_07045	ENOG4105DFF	Rod shape-determining protein mreb
IR04_07050	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
IR04_07055	ENOG4105VQ7	Rod shape-determining protein MreD
IR04_07060	ENOG4108Z03	MAF-like protein
IR04_07065	ENOG4105C03	ribonuclease
IR04_07070	ENOG4105QD6	exported protein
IR04_07080	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
IR04_07085	ENOG4105CEU	Arginine dihydrolase
IR04_07110	ENOG41081QV	Universal stress protein
IR04_07125	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
IR04_07130	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
IR04_07135	ENOG4105D5Q	Arginine ornithine antiporter
IR04_07140	ENOG4105D5Q	Arginine ornithine antiporter
IR04_07145	ENOG4105EAH	synthase
IR04_07150	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
IR04_07155	ENOG4105K46	50S ribosomal protein l27
IR04_07160	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IR04_07165	ENOG4105DWK	Membrane
IR04_07170	ENOG4107XM3	UPF0442 protein
IR04_07180	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
IR04_07185	ENOG4105NWN	ApaG protein
IR04_07190	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
IR04_07195	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
IR04_07200	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
IR04_07205	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
IR04_07210	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
IR04_07265	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
IR04_07270	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
IR04_07275	ENOG4105CEN	a g-specific adenine glycosylase
IR04_07280	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
IR04_07285	ENOG4105CSV	Glutaminase
IR04_07290	ENOG4105CSA	Coproporphyrinogen iii oxidase
IR04_07295	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
IR04_07305	ENOG4105VZ9	UPF0235 protein
IR04_07310	ENOG4108VIA	integral membrane protein
IR04_07315	ENOG4105II7	pyrroline-5-carboxylate reductase
IR04_07320	ENOG4105DFA	alanine racemase domain protein
IR04_07325	ENOG4105CZX	twitching motility protein
IR04_07330	ENOG4105CZX	twitching motility protein
IR04_07340	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
IR04_07345	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
IR04_07350	ENOG4108UJU	UPF0301 protein
IR04_07355	ENOG4105D7Z	glutathione synthase
IR04_07360	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
IR04_07365	ENOG4105RWS	endonuclease I
IR04_07370	ENOG4105GPY	SprT protein
IR04_07375	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
IR04_07385	ENOG4105CV1	Transketolase (EC 2.2.1.1)
IR04_07390	ENOG4108R4R	Iron-regulated virulence regulatory protein
IR04_07395	ENOG4105D05	Receptor
IR04_07400	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
IR04_07405	ENOG4105BZA	Phosphoglycerate kinase
IR04_07415	ENOG4105D2N	Aldolase
IR04_07425	ENOG4105D64	Mechanosensitive ion channel
IR04_07430	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
IR04_07435	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
IR04_07440	ENOG4105MPN	Membrane
IR04_07445	ENOG4105CA9	Pyruvate kinase
IR04_07450	ENOG410804X	Transcriptional regulator
IR04_07455	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
IR04_07460	ENOG4105CH5	extracellular solute-binding protein, family 7
IR04_07520	ENOG4105D58	Diguanylate phosphodiesterase
IR04_07525	ENOG4105DFP	Integrase
IR04_07535	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
IR04_07540	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
IR04_07545	ENOG4105KTH	gatB Yqey
IR04_07550	ENOG4105VCC	30S ribosomal protein S21
IR04_07555	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
IR04_07565	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
IR04_07570	ENOG4107ZVW	dihydroneopterin aldolase
IR04_07575	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR04_07580	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
IR04_07590	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
IR04_07595	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
IR04_07600	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
IR04_07605	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
IR04_07610	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
IR04_07615	ENOG4108K5P	(LipO)protein
IR04_07625	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
IR04_07630	ENOG4105C6T	cysteine synthase
IR04_07635	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
IR04_07640	ENOG4108I5D	sulfate abc transporter
IR04_07645	ENOG4105ECW	sulfate abc transporter
IR04_07650	ENOG4108IJ6	ABC transporter
IR04_07660	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
IR04_07665	ENOG4105Y3E	Modulates RecA activity (By similarity)
IR04_07670	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
IR04_07675	ENOG4105CFH	Aspartokinase
IR04_07680	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
IR04_07735	ENOG4107QSA	Oxaloacetate decarboxylase
IR04_07740	ENOG4105D9Q	decarboxylase (Beta subunit)
IR04_07750	ENOG4105W39	Membrane
IR04_07760	ENOG4105D9M	gamma-glutamylcysteine synthetase
IR04_07765	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
IR04_07770	ENOG4108JU6	CBS domain protein
IR04_07775	ENOG4106KVJ	cytochrome C assembly protein
IR04_07780	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IR04_07785	ENOG4105K5M	30s ribosomal protein S16
IR04_07790	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
IR04_07795	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
IR04_07800	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
IR04_07805	ENOG4105C0H	protease
IR04_07820	ENOG4105D6Z	AFG1 family ATPase
IR04_07825	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
IR04_07830	ENOG4108UJD	30S ribosomal protein S9
IR04_07835	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
IR04_07845	ENOG4105EIX	cytochrome c1
IR04_07850	ENOG4107MKT	Stringent starvation protein a
IR04_07855	ENOG4105KB2	stringent starvation protein b
IR04_07860	ENOG4105W4M	Transport-associated protein
IR04_07865	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
IR04_07870	ENOG41082RQ	UPF0102 protein
IR04_07875	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
IR04_07880	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
IR04_07885	ENOG410630P	Transcriptional regulator
IR04_07890	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
IR04_07895	ENOG41077A9	carbonic anhydrase
IR04_07900	ENOG4105CHH	sulfate transporter
IR04_07905	ENOG4105DA5	(ABC) transporter
IR04_07910	ENOG4105E3A	(ABC) transporter
IR04_07915	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
IR04_07920	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
IR04_07925	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR04_07930	ENOG4105DJ0	Poly(A) Polymerase
IR04_07935	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
IR04_07940	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IR04_07945	ENOG4105PW4	Sugar fermentation stimulation protein homolog
IR04_07955	ENOG4105CQ7	ATP-dependent helicase
IR04_07960	ENOG4105BZ4	penicillin-binding protein
IR04_07965	ENOG4105D78	K07001 NTE family protein
IR04_07970	ENOG4107QIJ	Aconitate hydratase 2
IR04_07975	ENOG4105XTV	UPF0231 protein
IR04_07980	ENOG4108YZA	Nitrogen regulatory protein pii
IR04_08000	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
IR04_08010	ENOG4105E2V	Glycosyltransferase 36
IR04_08015	ENOG4105E2D	ec 3.2.1.52
IR04_08020	ENOG4105RD7	BadF BadG BcrA BcrD
IR04_08030	ENOG4108JQ7	(ABC) transporter
IR04_08035	ENOG4105C3U	ABC transporter
IR04_08040	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
IR04_08050	ENOG4107QRA	Extracellular solute-binding protein, family 5
IR04_08055	ENOG4105BZU	Histidine kinase
IR04_08060	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
IR04_08065	ENOG4105IPI	Membrane
IR04_08070	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
IR04_08080	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
IR04_08095	ENOG4105DR5	peptidase
IR04_08100	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
IR04_08105	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
IR04_08110	ENOG4105FCK	Membrane
IR04_08115	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
IR04_08120	ENOG4105HBR	Rna-binding protein
IR04_08125	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
IR04_08130	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
IR04_08135	ENOG4105EEI	dihydropteroate synthase
IR04_08140	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
IR04_08160	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
IR04_08165	ENOG4105CHV	Transcription elongation factor NusA
IR04_08170	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
IR04_08175	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
IR04_08180	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
IR04_08185	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
IR04_08190	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
IR04_08195	ENOG4105RT1	May be involved in cell division (By similarity)
IR04_08210	ENOG4106RZ4	Peptidase U32
IR04_08215	ENOG4105CFP	Peptidase U32
IR04_08220	ENOG4105BZU	Histidine kinase
IR04_08225	ENOG4105XPQ	lipid carrier protein
IR04_08230	ENOG4108YYD	acetyltransferase
IR04_08245	ENOG4105BZU	Histidine kinase
IR04_08330	ENOG4108R0M	Aminoglycoside
IR04_08360	ENOG4105KT5	UmuD protein
IR04_08495	ENOG4105T95	Thiol disulfide interChange protein
IR04_08550	ENOG4105RWS	endonuclease I
IR04_08565	ENOG4108UUM	single-stranded DNA-binding protein
IR04_08585	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
IR04_08610	ENOG4108YGG	dna repair protein
IR04_08635	ENOG4108KB1	transcriptional regulator, arac family
IR04_08720	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
IR04_08725	ENOG4105C1J	atp-dependent rna helicase
IR04_08730	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
IR04_08735	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
IR04_08740	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
IR04_08745	ENOG4105CRK	lysyL-tRNA synthetase
IR04_08750	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_08760	ENOG4105CPC	Aldo Keto reductase
IR04_08765	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
IR04_08775	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
IR04_08780	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
IR04_08785	ENOG4105HF0	Membrane
IR04_08790	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
IR04_08795	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
IR04_08805	ENOG41063Z6	transcriptional regulator, lysR family
IR04_08810	ENOG41080HT	Transcriptional regulator, arsr family
IR04_08815	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
IR04_08820	ENOG4105CJR	Integral membrane protein (MviN
IR04_08825	ENOG4105DTN	riboflavin biosynthesis protein ribF
IR04_08830	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
IR04_08835	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
IR04_08840	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
IR04_08845	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
IR04_08865	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR04_08870	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
IR04_08875	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
IR04_08880	ENOG4108NEV	two component transcriptional regulator, LytTR family
IR04_08885	ENOG4108HRK	Histidine kinase
IR04_08890	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
IR04_08905	ENOG4105C5H	ABC transporter
IR04_08910	ENOG4107SC1	transglycosylase
IR04_08915	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
IR04_08920	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
IR04_08925	ENOG4108K0B	C-di-gmp phosphodiesterase
IR04_08930	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
IR04_08940	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
IR04_08945	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR04_08950	ENOG4105C34	Pseudouridine synthase
IR04_08955	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
IR04_08960	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
IR04_09000	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
IR04_09005	ENOG4105CFP	Peptidase U32
IR04_09010	ENOG4105DH7	May be involved in recombination (By similarity)
IR04_09015	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
IR04_09020	ENOG4105BZU	Histidine kinase
IR04_09030	ENOG4105C9X	ppx gppa phosphatase
IR04_09035	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
IR04_09040	ENOG4105C8U	phosphate abc transporter
IR04_09045	ENOG4105E2Z	phosphate ABC transporter (Permease
IR04_09050	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
IR04_09060	ENOG4105CSR	polyphosphate kinase 2
IR04_09065	ENOG4106N3A	copper homeostasis protein cutc
IR04_09070	ENOG4105D3R	alkyl hydroperoxide reductase
IR04_09075	ENOG4105C5Q	Transcriptional regulator
IR04_09080	ENOG4107QP3	malate synthase g
IR04_09085	ENOG4108I9X	Isocitrate lyase
IR04_09090	ENOG4105W87	Cbs domain
IR04_09095	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
IR04_09100	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
IR04_09105	ENOG4105VIE	preprotein translocase, subunit YajC
IR04_09110	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
IR04_09115	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
IR04_09120	ENOG4105ECY	inositol monophosphatase
IR04_09125	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
IR04_09130	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
IR04_09135	ENOG4105C3J	Cysteine desulfurase
IR04_09140	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
IR04_09145	ENOG4108Z4V	iron-sulfur cluster assembly
IR04_09150	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
IR04_09155	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
IR04_09160	ENOG4108ZIT	Ferredoxin, 2FE-2S
IR04_09165	ENOG4105WVQ	Fe-S assembly protein IscX
IR04_09170	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
IR04_09175	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
IR04_09180	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
IR04_09190	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
IR04_09195	ENOG4105CUT	histidyl-tRNA synthetase
IR04_09200	ENOG4105N21	Membrane
IR04_09205	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
IR04_09210	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
IR04_09225	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
IR04_09230	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
IR04_09235	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
IR04_09250	ENOG4106HK8	GPR1 FUN34 yaaH family protein
IR04_09255	ENOG4105WQI	isochorismatase
IR04_09260	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
IR04_09265	ENOG4105E4F	Isochorismate synthase
IR04_09270	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
IR04_09280	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
IR04_09285	ENOG4105DQ5	transport system permease protein
IR04_09290	ENOG4105TVJ	transport system, permease
IR04_09295	ENOG4105E0A	ABC, transporter
IR04_09305	ENOG41064T2	transcriptional regulator, lysR family
IR04_09310	ENOG4105EUZ	Beta-lactamase domain protein
IR04_09315	ENOG4105BZG	amino acid carrier protein
IR04_09320	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
IR04_09340	ENOG4106YYS	transcriptional regulatory protein
IR04_09345	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
IR04_09350	ENOG4105D9Q	decarboxylase (Beta subunit)
IR04_09355	ENOG4107QSA	Oxaloacetate decarboxylase
IR04_09370	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
IR04_09375	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
IR04_09380	ENOG4105CI0	Citrate lyase
IR04_09385	ENOG4105CHY	citrate lyase, alpha
IR04_09390	ENOG4105YGP	holo-ACP synthase CitX
IR04_09395	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
IR04_09410	ENOG4108Z4U	Ferredoxin
IR04_09415	ENOG4105DZ0	fad dependent oxidoreductase
IR04_09475	ENOG4105C26	Dehydrogenase
IR04_09495	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
IR04_09500	ENOG4107RK6	Methyl-accepting chemotaxis
IR04_09515	ENOG4105XB6	Toxin coregulated pilin
IR04_09530	ENOG4105GRU	toxin co-regulated pilus biosynthesis outer membrane protein C
IR04_09550	ENOG4107QHF	type ii secretion system protein e
IR04_09555	ENOG4108VEY	type ii secretion system
IR04_09570	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
IR04_09575	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_09595	ENOG4105DR5	peptidase
IR04_09605	ENOG4105F88	accessory colonization factor AcfD
IR04_09615	ENOG4105DFP	Integrase
IR04_09620	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
IR04_09625	ENOG4108Z1B	Cyclase dehydrase
IR04_09630	ENOG4105VDB	UPF0125 protein
IR04_09635	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
IR04_09640	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
IR04_09645	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
IR04_09650	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IR04_09655	ENOG4105CFG	Acts as a chaperone (By similarity)
IR04_09660	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
IR04_09690	ENOG4105CFC	Transporter
IR04_09695	ENOG4108Z6B	deaminase
IR04_09705	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
IR04_09720	ENOG4108RS6	transposase
IR04_09740	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
IR04_09745	ENOG4108R96	Methyltransferase, YaeB family
IR04_09750	ENOG4105NRA	50s ribosomal protein l31 type b
IR04_09760	ENOG4105CFC	Transporter
IR04_09765	ENOG4108UPT	UPF0178 protein
IR04_09775	ENOG4108428	Inherit from COG: -acetyltransferase
IR04_09790	ENOG4105WP7	tRNA pseudouridine synthase C
IR04_09795	ENOG4105DR9	pseudouridine synthase
IR04_09800	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
IR04_09805	ENOG4105CTB	Polyprenyl synthetase
IR04_09815	ENOG4105E14	MotA TolQ exbB proton channel
IR04_09825	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
IR04_09835	ENOG4105ETT	transcriptional Regulator, LysR family
IR04_09840	ENOG4105M08	Membrane
IR04_09850	ENOG4105EWT	decarboxylase family
IR04_09855	ENOG4105BZU	Histidine kinase
IR04_09865	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
IR04_09870	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
IR04_09875	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
IR04_09880	ENOG4105D01	(LipO)protein
IR04_09885	ENOG4108UMI	ABC transporter, permease
IR04_09890	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
IR04_09895	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
IR04_09900	ENOG4105D4X	repressor
IR04_09905	ENOG4105C5Y	PTS System
IR04_09910	ENOG4105CG3	alpha amylase, catalytic region
IR04_09940	ENOG4107ZF2	Phosphatase
IR04_09945	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
IR04_09955	ENOG4108UW5	maltose o-acetyltransferase
IR04_09975	ENOG4105D7W	serine acetyltransferase
IR04_09985	ENOG4105Q84	sucrose synthase
IR04_09995	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
IR04_10010	ENOG4108MA4	Peptidase M66
IR04_10025	ENOG4105D3Q	Sugar transferase
IR04_10035	ENOG4105DAY	polysaccharide export protein
IR04_10040	ENOG4105D75	Capsular exopolysaccharide family
IR04_10060	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
IR04_10070	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
IR04_10075	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
IR04_10080	ENOG4108Z43	UPF0250 protein
IR04_10085	ENOG4105DZ1	carboxypeptidase
IR04_10090	ENOG4105K6T	rare lipoprotein A
IR04_10095	ENOG4105CNI	cell division protein FtsW
IR04_10100	ENOG4105CJN	penicillin-binding protein
IR04_10105	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
IR04_10110	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
IR04_10115	ENOG4105DJF	DNA polymerase III, delta' subunit
IR04_10120	ENOG4108U2H	Rare lipoprotein B
IR04_10125	ENOG4105C8T	Leucyl-tRNA synthetase
IR04_10130	ENOG4107PAI	alpha helical protein
IR04_10135	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
IR04_10140	ENOG4108JU5	Magnesium and cobalt efflux protein
IR04_10145	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
IR04_10150	ENOG4105C9A	Phoh family
IR04_10155	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
IR04_10160	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
IR04_10165	ENOG4105C5Y	PTS System
IR04_10175	ENOG4105KZ7	phosphocarrier protein hpr
IR04_10180	ENOG4105C6T	cysteine synthase
IR04_10185	ENOG4105EXN	Sulfate transport protein CysZ
IR04_10190	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
IR04_10195	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
IR04_10200	ENOG41081QG	Porin Gram-negative type
IR04_10210	ENOG4108Z6Z	Transcriptional regulator
IR04_10215	ENOG4105G5H	Membrane
IR04_10220	ENOG4107QX8	SPFH domain, Band 7 family protein
IR04_10225	ENOG4107QR8	Thioredoxin
IR04_10235	ENOG4105E1F	short-chain dehydrogenase reductase
IR04_10240	ENOG4105ECP	epimerase
IR04_10245	ENOG4108RE9	Phosphodiesterase
IR04_10260	ENOG4108TU9	TRANSCRIPTIONal
IR04_10265	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
IR04_10270	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
IR04_10275	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
IR04_10280	ENOG4105DUX	Transporter
IR04_10285	ENOG4105MDZ	Transcriptional activator rfaH
IR04_10290	ENOG4105CAQ	asparagine synthetase
IR04_10295	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
IR04_10300	ENOG4105E2R	ROK family
IR04_10305	ENOG4105CE4	GlcNAc 6-P deacetylase
IR04_10310	ENOG4105CI1	PTS System
IR04_10315	ENOG4105CX6	glutaminyL-tRNA synthetase
IR04_10325	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
IR04_10330	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
IR04_10335	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
IR04_10340	ENOG4108S3P	Sporulation domain protein
IR04_10345	ENOG4105E96	Colicin v production protein
IR04_10350	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
IR04_10355	ENOG4105D3Y	Na H antiporter
IR04_10360	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
IR04_10370	ENOG4105EIY	sodium-type flagellar protein motY
IR04_10375	ENOG4106WH9	Protein of unknown function (DUF2753)
IR04_10380	ENOG4108UYE	Lactoylglutathione lyase
IR04_10385	ENOG4105CSM	endonuclease III
IR04_10390	ENOG4105DZB	Electron transport complex
IR04_10395	ENOG4108UQQ	Electron transport complex
IR04_10400	ENOG4105D6A	Electron transport complex
IR04_10410	ENOG4108R3D	Electron transport complex
IR04_10430	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
IR04_10440	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_10450	ENOG4105CHW	UPF0052 protein
IR04_10455	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
IR04_10460	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
IR04_10465	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
IR04_10470	ENOG4105M00	molybdopterin converting factor, subunit 1
IR04_10475	ENOG4108ZAF	Molybdopterin
IR04_10480	ENOG4105BZU	Histidine kinase
IR04_10495	ENOG4108I5U	Uridine phosphorylase
IR04_10505	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
IR04_10510	ENOG4105D1F	ATP-binding protein
IR04_10520	ENOG4105DBI	uridine monophosphokinase
IR04_10525	ENOG4108GAE	asmA family
IR04_10530	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
IR04_10540	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
IR04_10545	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
IR04_10570	ENOG4105CHU	acetyl-coa acetyltransferase
IR04_10575	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
IR04_10580	ENOG41069NU	Nitroreductase
IR04_10585	ENOG4105EJC	lysr family transcriptional regulator
IR04_10590	ENOG4105I93	response regulator
IR04_10600	ENOG4105WD1	Membrane
IR04_10605	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
IR04_10610	ENOG4107QMP	dna polymerase iii subunits gamma and tau
IR04_10615	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
IR04_10620	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
IR04_10625	ENOG4105KRS	Proteinase inhibitor
IR04_10635	ENOG4105UBK	short-chain dehydrogenase reductase
IR04_10640	ENOG4105ERU	peptidase
IR04_10650	ENOG4108XM1	transcriptional regulator AsnC family
IR04_10675	ENOG4105BZU	Histidine kinase
IR04_10680	ENOG41082YX	Transcriptional regulator, arsr family
IR04_10685	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
IR04_10710	ENOG4108V1U	phospholipid-binding protein
IR04_10730	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
IR04_10745	ENOG4107YTP	response regulator receiver protein
IR04_10755	ENOG4105BZU	Histidine kinase
IR04_10760	ENOG4105BZU	Histidine kinase
IR04_10765	ENOG4105BZU	Histidine kinase
IR04_10770	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_10785	ENOG4107QSI	ABC, transporter
IR04_10790	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
IR04_10795	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
IR04_10800	ENOG4105C3U	ABC transporter
IR04_10805	ENOG4108JQ7	(ABC) transporter
IR04_10810	ENOG4105CHF	Glutathione S-transferase
IR04_10815	ENOG4108DNC	Involved in acetate metabolism (By similarity)
IR04_10820	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
IR04_10825	ENOG4105PQ6	UPF0208 membrane protein
IR04_10830	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
IR04_10840	ENOG4105C7J	ABC transporter, permease
IR04_10845	ENOG4108JJB	ABC transporter
IR04_10850	ENOG4105BZU	Histidine kinase
IR04_10855	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
IR04_10860	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
IR04_10870	ENOG4105D1H	recombination factor protein RarA
IR04_10875	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
IR04_10880	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
IR04_10885	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
IR04_10890	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
IR04_10895	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
IR04_10900	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
IR04_10910	ENOG4105D0M	Protease HtpX homolog
IR04_10920	ENOG4107FW0	short-chain dehydrogenase reductase
IR04_10935	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
IR04_10945	ENOG4105RHG	
IR04_10955	ENOG4107QTF	adenylosuccinate lyase
IR04_10960	ENOG41075W9	High frequency lysogenization protein HflD homolog
IR04_10965	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
IR04_10970	ENOG4107RE1	Inosine-guanosine kinase
IR04_10980	ENOG4107S6Z	Na H antiporter
IR04_10985	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
IR04_10990	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
IR04_10995	ENOG4105CIH	Imidazole acetol-phosphate transaminase
IR04_11000	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
IR04_11005	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
IR04_11010	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
IR04_11015	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
IR04_11020	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
IR04_11025	ENOG4108R99	pseudouridine synthase
IR04_11035	ENOG4105VEQ	Cold shock protein
IR04_11040	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
IR04_11045	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
IR04_11055	ENOG41090BQ	Glutaredoxin
IR04_11060	ENOG4108EKI	Dehydrogenase
IR04_11065	ENOG4106KNT	transcriptional regulator
IR04_11070	ENOG4105DY8	decarboxylase
IR04_11080	ENOG4105DWU	Membrane
IR04_11105	ENOG4105CUX	Signal transduction histidine kinase
IR04_11115	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
IR04_11130	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
IR04_11135	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
IR04_11140	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
IR04_11145	ENOG41081XQ	Conserved Protein
IR04_11150	ENOG4105C9M	aspartyl-trna synthetase
IR04_11155	ENOG4107104	thymidine kinase
IR04_11160	ENOG4105CK2	sodium dicarboxylate symporter
IR04_11165	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
IR04_11170	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
IR04_11175	ENOG4105DK0	Indole-3-glycerol phosphate synthase
IR04_11180	ENOG4108I0Q	anthranilate phosphoribosyltransferase
IR04_11185	ENOG4105DDQ	anthranilate synthase
IR04_11190	ENOG4105CRQ	synthase (Component I)
IR04_11200	ENOG4105DB7	PHP domain protein
IR04_11205	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
IR04_11210	ENOG4105FE9	pseudouridine synthase
IR04_11215	ENOG4108JJ8	(ABC) transporter
IR04_11220	ENOG4108JJ9	ABC, transporter
IR04_11225	ENOG4105C3M	thioredoxin reductase
IR04_11235	ENOG4105C9B	Cysteine desulfurase
IR04_11240	ENOG4105BZU	Histidine kinase
IR04_11245	ENOG4107GZ4	SanA protein
IR04_11255	ENOG4107R1I	NAD-dependent malic enzyme
IR04_11265	ENOG4105C8V	SAICAR synthetase
IR04_11285	ENOG4108ZG0	Ompa motb domain protein
IR04_11305	ENOG4105CQB	FAD linked oxidase domain protein
IR04_11315	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
IR04_11325	ENOG4105C84	Histidine ammonia-lyase
IR04_11330	ENOG4105CGP	Urocanate hydratase
IR04_11335	ENOG41088SP	formiminoglutamate hydrolase
IR04_11340	ENOG4105CI2	imidazolone-5-propionate hydrolase
IR04_11345	ENOG4105CZE	histidine utilization repressor
IR04_11360	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
IR04_11370	ENOG4105BZU	Histidine kinase
IR04_11375	ENOG4105CQ2	DNA polymerase
IR04_11380	ENOG4105WH1	Two component transcriptional regulator luxr family
IR04_11385	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
IR04_11415	ENOG4105BZU	Histidine kinase
IR04_11425	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
IR04_11430	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
IR04_11435	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
IR04_11450	ENOG4105FQ6	thiopurine methyltransferase
IR04_11465	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
IR04_11470	ENOG41067MG	lrgb family
IR04_11480	ENOG4105CJB	Exodeoxyribonuclease I
IR04_11485	ENOG4108ETY	sodium dicarboxylate symporter
IR04_11490	ENOG4105E0X	reductase
IR04_11500	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
IR04_11505	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
IR04_11510	ENOG4108YZT	Adenosylcobinamide kinase
IR04_11525	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
IR04_11530	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
IR04_11545	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_11570	ENOG4107QK7	reductase
IR04_11575	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
IR04_11580	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
IR04_11585	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
IR04_11590	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IR04_11595	ENOG4105C72	UPF0176 protein
IR04_11605	ENOG4105S8Q	sugar efflux transporter
IR04_11615	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
IR04_11640	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
IR04_11645	ENOG4105EAQ	(twin-arginine translocation) pathway signal
IR04_11650	ENOG4105C5X	domain protein
IR04_11665	ENOG4105CH5	extracellular solute-binding protein, family 7
IR04_11675	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
IR04_11690	ENOG41067TZ	transcriptional regulator, MarR family
IR04_11695	ENOG4105C94	Transporter
IR04_11705	ENOG4105VZJ	PTS System
IR04_11715	ENOG4105VCP	PTS System
IR04_11720	ENOG4105F8D	glycoside hydrolase family 4
IR04_11725	ENOG410901P	UPF0249 protein
IR04_11730	ENOG41060NJ	transcriptional regulator
IR04_11735	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
IR04_11740	ENOG4105DJ9	glucan biosynthesis protein
IR04_11745	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_11760	ENOG4105CGF	Aromatic amino acid aminotransferase
IR04_11770	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
IR04_11780	ENOG4105C5S	asparaginyl-tRNA synthetase
IR04_11785	ENOG4108NVR	Methyl-accepting chemotaxis
IR04_11790	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
IR04_11795	ENOG4105EJQ	L-serine dehydratase
IR04_11800	ENOG4105C44	Serine transporter
IR04_11805	ENOG4105P8F	nudix hydrolase
IR04_11810	ENOG4105CRQ	synthase (Component I)
IR04_11825	ENOG4105CM6	amino acid regulated cytosolic protein
IR04_11835	ENOG4108JU8	Transcriptional regulator
IR04_11840	ENOG4105D9U	N-acetyltransferase
IR04_11855	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
IR04_11860	ENOG4108NVR	Methyl-accepting chemotaxis
IR04_11865	ENOG4105C8P	)-transporter
IR04_11870	ENOG4105BZU	Histidine kinase
IR04_11875	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_11880	ENOG4108MJ5	VirK protein
IR04_11885	ENOG4105RW8	MltA-interacting MipA family protein
IR04_11890	ENOG4105EB3	Histidine kinase
IR04_11895	ENOG4107EXC	regulatoR
IR04_11920	ENOG4105C2J	ABC transporter
IR04_11925	ENOG4107SDZ	Galactoside transport system permease protein mglC
IR04_11955	ENOG41073TP	transcriptional regulator
IR04_11960	ENOG4105CR4	methylisocitrate lyase
IR04_11965	ENOG4105BZN	citrate synthase
IR04_11970	ENOG4108I0Z	Aconitate hydratase
IR04_11975	ENOG4105C7F	AcnD-accessory protein PrpF
IR04_11980	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
IR04_11995	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
IR04_12005	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
IR04_12010	ENOG4105F1J	Homogentisate 1,2-dioxygenase
IR04_12020	ENOG4108RXX	maleylacetoacetate isomerase
IR04_12025	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
IR04_12030	ENOG4105BZU	Histidine kinase
IR04_12040	ENOG4106TD9	Diguanylate cyclase
IR04_12045	ENOG4105DR4	Methyltransferase
IR04_12050	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
IR04_12055	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
IR04_12060	ENOG4108MN8	Membrane
IR04_12070	ENOG4105DRP	amino acid AbC transporter
IR04_12075	ENOG4105EZ7	amino acid ABC transporter
IR04_12080	ENOG4107QXX	ABC transporter
IR04_12090	ENOG410667J	hydrolase
IR04_12095	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
IR04_12100	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
IR04_12120	ENOG4105BZU	Histidine kinase
IR04_12130	ENOG4105BZU	Histidine kinase
IR04_12135	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
IR04_12140	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
IR04_12150	ENOG4105BZU	Histidine kinase
IR04_12170	ENOG4105CQ7	ATP-dependent helicase
IR04_12180	ENOG4105R8A	Heat shock protein
IR04_12190	ENOG4105EJC	lysr family transcriptional regulator
IR04_12200	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
IR04_12205	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
IR04_12210	ENOG4105KPY	Small multidrug resistance protein
IR04_12215	ENOG4108NVR	Methyl-accepting chemotaxis
IR04_12220	ENOG4108VYJ	response regulator receiver protein
IR04_12230	ENOG4105CBS	Chea signal transduction histidine kinase
IR04_12235	ENOG4105CBS	Chea signal transduction histidine kinase
IR04_12240	ENOG4105BZU	Histidine kinase
IR04_12250	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
IR04_12255	ENOG4108V3W	Chemotaxis protein, CheW
IR04_12265	ENOG4108N3W	hemolysin secretion protein
IR04_12270	ENOG4107SDU	Methyl-accepting chemotaxis
IR04_12275	ENOG4105C1J	atp-dependent rna helicase
IR04_12285	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
IR04_12290	ENOG4105CW7	secretion protein, HlyD family
IR04_12295	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
IR04_12300	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_12305	ENOG4105CTD	carboxy-peptidase
IR04_12310	ENOG4108WC9	type VI secretion system effector, hcp1 family
IR04_12315	ENOG4105CS6	Rhs element vgr protein
IR04_12340	ENOG410829K	Lysine exporter protein (Lyse ygga)
IR04_12345	ENOG4105BZG	amino acid carrier protein
IR04_12360	ENOG4107RUE	extracellular solute-binding protein family 1
IR04_12365	ENOG4107RUE	extracellular solute-binding protein family 1
IR04_12370	ENOG4105D38	putrescine abc transporter
IR04_12375	ENOG4105F38	ABC transporter, permease
IR04_12380	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
IR04_12400	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
IR04_12405	ENOG4105Q9Y	Universal stress protein
IR04_12410	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
IR04_12425	ENOG4105C59	p-type ATPase
IR04_12435	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
IR04_12450	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
IR04_12465	ENOG4105BZU	Histidine kinase
IR04_12490	ENOG4108RC6	RTX toxin
IR04_12495	ENOG4105EUK	rtx toxin RtxA
IR04_12515	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
IR04_12525	ENOG4107927	Cholera enterotoxin, A subunit
IR04_12530	ENOG4105MQ5	zona occludens toxin
IR04_12565	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
IR04_12650	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
IR04_12655	ENOG4105DAN	ATP-dependent protease
IR04_12660	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
IR04_12670	ENOG4105C5H	ABC transporter
IR04_12680	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
IR04_12685	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
IR04_12690	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
IR04_12695	ENOG4105C7I	Dehydrogenase
IR04_12705	ENOG4105CD8	aminopeptidase N
IR04_12715	ENOG4105CN1	protease
IR04_12720	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
IR04_12725	ENOG4108ZGC	gaf domain protein
IR04_12730	ENOG4105BZ1	(ABC) transporter
IR04_12735	ENOG4105H2K	paraquat-inducible protein a
IR04_12740	ENOG4105DY2	Paraquat-inducible protein b
IR04_12745	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
IR04_12750	ENOG4105QNR	S1 RNA binding domain protein
IR04_12765	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
IR04_12775	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
IR04_12790	ENOG4105QAX	Iron-sulfur
IR04_12795	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
IR04_12805	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
IR04_12825	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
IR04_12830	ENOG4105C5H	ABC transporter
IR04_12835	ENOG4105BZU	Histidine kinase
IR04_12840	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_12850	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
IR04_12855	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
IR04_12860	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
IR04_12865	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
IR04_12890	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
IR04_12895	ENOG4106IUH	DTW domain containing protein
IR04_12905	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_12910	ENOG4107TT5	NLP P60 protein
IR04_12930	ENOG4107QI1	Mate efflux family protein
IR04_12950	ENOG41067XB	TonB family
IR04_12955	ENOG4109015	Biopolymer transport protein exbD tolR
IR04_12985	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
IR04_12990	ENOG4108IJ9	(ABC) transporter
IR04_12995	ENOG4105E98	transcriptional regulator DeoR family
IR04_13000	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
IR04_13005	ENOG4105XEP	YhcH YjgK YiaL family protein
IR04_13010	ENOG4105M4H	endoribonuclease L-psp
IR04_13015	ENOG4105DDV	Transcriptional regulator (LacI family
IR04_13020	ENOG4105CS2	ec 3.2.1.21
IR04_13040	ENOG4107QZV	Type I secretion membrane fusion protein
IR04_13050	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
IR04_13055	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
IR04_13060	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
IR04_13065	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
IR04_13070	ENOG4105C4M	(Ubiquinol oxidase) subunit I
IR04_13080	ENOG4105C9Q	fumarate hydratase class II
IR04_13110	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
IR04_13115	ENOG4105DUM	transcriptional regulator, lysR family
IR04_13120	ENOG4108TWJ	NADH dehydrogenase subunit 5
IR04_13130	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
IR04_13160	ENOG4105C7K	acetolactate synthase
IR04_13170	ENOG4105BZU	Histidine kinase
IR04_13175	ENOG4106TD9	Diguanylate cyclase
IR04_13180	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
IR04_13185	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
IR04_13190	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
IR04_13215	ENOG4105BZU	Histidine kinase
IR04_13230	ENOG4107R88	Chemotaxis protein (CheV)
IR04_13240	ENOG4106YYS	transcriptional regulatory protein
IR04_13245	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
IR04_13260	ENOG4107V40	secretion protein, HlyD family
IR04_13280	ENOG4105CVG	Homoserine O-transsuccinylase
IR04_13285	ENOG41090FY	type IV pilus biogenesis stability protein PilW
IR04_13295	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
IR04_13300	ENOG4108VKG	metal-dependent hydrolase
IR04_13310	ENOG4105F04	LysR family Transcriptional regulator
IR04_13330	ENOG4105DFG	type I secretion outer membrane protein
IR04_13335	ENOG4105CDV	Ompa motb domain protein
IR04_13340	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
IR04_13345	ENOG4105E3Q	saccharopine dehydrogenase
IR04_13355	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
IR04_13370	ENOG4108I0Y	(ABC) transporter
IR04_13375	ENOG4105UQX	Mate efflux family protein
IR04_13380	ENOG4105CGD	Nad-dependent epimerase dehydratase
IR04_13390	ENOG4105C2C	drug resistance transporter, Bcr CflA
IR04_13395	ENOG4105I08	Pseudouridine synthase
IR04_13400	ENOG4105CFI	type iii restriction protein res subunit
IR04_13420	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
IR04_13440	ENOG4108N3W	hemolysin secretion protein
IR04_13470	ENOG4105KXC	Collagenase
IR04_13480	ENOG4105BZU	Histidine kinase
IR04_13485	ENOG4105BZU	Histidine kinase
IR04_13490	ENOG4105CJW	magnesium transporter
IR04_13505	ENOG4105C44	Serine transporter
IR04_13515	ENOG4105CJ1	ABC, transporter
IR04_13520	ENOG4107QWP	ABC-2 type transporter
IR04_13530	ENOG4105XZD	Fe-S protein
IR04_13540	ENOG4105VNH	ABC transporter solute-binding protein
IR04_13545	ENOG4105CXZ	ABC transporter, permease
IR04_13550	ENOG4108VGW	abc transporter atp-binding protein
IR04_13555	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
IR04_13560	ENOG4108W1A	pseudouridine synthase
IR04_13565	ENOG4105C8J	)-transporter
IR04_13570	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
IR04_13575	ENOG4105C28	cystathionine
IR04_13580	ENOG4108R3E	Dna-3-methyladenine glycosylase i
IR04_13595	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
IR04_13610	ENOG41087YS	Phage shock protein A
IR04_13615	ENOG4105E51	psp operon transcriptional activator
IR04_13620	ENOG4108J59	Extracellular solute-binding protein, family 5
IR04_13625	ENOG4108I5W	peptide transport system, permease protein
IR04_13630	ENOG4108EU3	peptide transport system, permease
IR04_13635	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
IR04_13640	ENOG4108JQ2	peptide transport system atp-binding protein
IR04_13655	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
IR04_13675	ENOG4107QY8	reductase
IR04_13695	ENOG4105TMB	Formate nitrite transporter
IR04_13705	ENOG4108535	NAD dependent epimerase/dehydratase family
IR04_13710	ENOG4105GFG	DUF218 domain
IR04_13720	ENOG4107835	probably involved in intracellular septation (By similarity)
IR04_13725	ENOG4105NAU	thioesterase Superfamily protein
IR04_13730	ENOG4105K9H	YciI-like protein
IR04_13740	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
IR04_13745	ENOG4105DZ2	Transcriptional regulator
IR04_13765	ENOG4105BZU	Histidine kinase
IR04_13770	ENOG4105CCT	upf0313 protein
IR04_13780	ENOG4105EW9	transcriptional regulator AsnC family
IR04_13785	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
IR04_13790	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
IR04_13800	ENOG4106371	Methyltransferase
IR04_13805	ENOG4107S90	membrAne
IR04_13810	ENOG4106WF9	DNA-binding transcriptional regulator TorR
IR04_13815	ENOG4108SBI	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
IR04_13820	ENOG4105ETE	Transcriptional regulator (LacI family
IR04_13825	ENOG4105HP8	regulator of competence-specific genes
IR04_13845	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
IR04_13850	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
IR04_13860	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
IR04_13865	ENOG4105RKX	Protein of unknown function (DUF2498)
IR04_13870	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
IR04_13880	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
IR04_13885	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
IR04_13890	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
IR04_13900	ENOG4107QPN	acyl-Coa dehydrogenase
IR04_13905	ENOG41067SE	Tetr family transcriptional regulator
IR04_13915	ENOG4105MTM	Protein of unknown function (DUF1496)
IR04_13920	ENOG4105C26	Dehydrogenase
IR04_13925	ENOG4108R86	Transcriptional regulator
IR04_13950	ENOG4105F1S	paraquat-inducible protein a
IR04_13955	ENOG4105DY2	Paraquat-inducible protein b
IR04_13980	ENOG4105DFP	Integrase
IR04_13990	ENOG4105C0D	helicase
IR04_14010	ENOG4105DZR	Type I site-specific deoxyribonuclease
IR04_14030	ENOG4105CVR	type I restriction-modification system
IR04_14050	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
IR04_14055	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
IR04_14060	ENOG4105QEK	Transcriptional regulator
IR04_14070	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
IR04_14075	ENOG41069H7	transport system small permease component
IR04_14080	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
IR04_14085	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
IR04_14090	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
IR04_14095	ENOG4105CE4	GlcNAc 6-P deacetylase
IR04_14110	ENOG4108YGG	dna repair protein
IR04_14130	ENOG4108NYK	Tape measure protein
IR04_14250	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
IR04_14260	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
IR04_14265	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
IR04_14270	ENOG4105C26	Dehydrogenase
IR04_14280	ENOG4105DM4	PTS System
IR04_14285	ENOG4105DM4	PTS System
IR04_14290	ENOG4108YRF	PTS System
IR04_14300	ENOG4106R3P	AraC family transcriptional regulator
IR04_14305	ENOG4105DM4	PTS System
IR04_14310	ENOG4105EIP	mannose-6-phosphate isomerase
IR04_14315	ENOG4108RNS	Exports L-alanine (By similarity)
IR04_14320	ENOG4105BZU	Histidine kinase
IR04_14330	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
IR04_14340	ENOG4105KCK	Peptidoglycan-associated lipoprotein
IR04_14345	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
IR04_14355	ENOG4105M8F	Biopolymer transport protein exbD tolR
IR04_14360	ENOG4105E02	MotA TolQ exbB proton channel
IR04_14365	ENOG4107YD3	Thioesterase
IR04_14370	ENOG4105KJB	cyd operon protein YbgE
IR04_14380	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
IR04_14385	ENOG4105C4M	(Ubiquinol oxidase) subunit I
IR04_14395	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
IR04_14400	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
IR04_14405	ENOG4105C8N	cysteinyl-tRNA synthetase
IR04_14410	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
IR04_14415	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
IR04_14420	ENOG4105D58	Diguanylate phosphodiesterase
IR04_14435	ENOG4105ZU8	porin-like protein H
IR04_14440	ENOG4105DVT	helicase
IR04_14445	ENOG4105EJ9	Membrane
IR04_14450	ENOG4108URS	primosomal replication protein n''
IR04_14455	ENOG4106428	Protein of unknown function (DUF2496)
IR04_14460	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_14465	ENOG4105CGK	Exodeoxyribonuclease III
IR04_14470	ENOG4106YG3	ABC transporter
IR04_14475	ENOG4105DSP	amino acid AbC transporter
IR04_14480	ENOG4105E89	ABC transporter
IR04_14485	ENOG4108JEH	abc transporter atp-binding protein
IR04_14495	ENOG4105C6N	Formate acetyltransferase
IR04_14505	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_14510	ENOG4105F1A	Pyruvate formate-lyase
IR04_14520	ENOG4105XWI	UPF0304 protein
IR04_14525	ENOG4105CYN	Serine protein kinase
IR04_14530	ENOG4106AKX	UPF0229 protein
IR04_14535	ENOG4105ED1	spovr family
IR04_14540	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
IR04_14550	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
IR04_14555	ENOG4105BZ1	(ABC) transporter
IR04_14560	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
IR04_14570	ENOG4105D60	lipoprotein releasing system transmembrane protein
IR04_14575	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
IR04_14580	ENOG4105D60	lipoprotein releasing system transmembrane protein
IR04_14590	ENOG4108JA2	transcriptioN-repair coupling factor
IR04_14600	ENOG4106M3D	hemolysin
IR04_14610	ENOG4105CEP	NADH dehydrogenase
IR04_14640	ENOG4105K59	histidine triad (HIT) protein
IR04_14645	ENOG4108NVR	Methyl-accepting chemotaxis
IR04_14655	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
IR04_14660	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
IR04_14665	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
IR04_14670	ENOG4105CNU	cell division protein FtsK
IR04_14680	ENOG4105EW9	transcriptional regulator AsnC family
IR04_14685	ENOG4105DCF	alanine dehydrogenase
IR04_14695	ENOG4107R11	Transcriptional regulator
IR04_14710	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
IR04_14715	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
IR04_14720	ENOG4105CFV	Tetratricopeptide repeat protein
IR04_14725	ENOG4105Q4A	inner membrane protein yciS
IR04_14730	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
IR04_14735	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
IR04_14740	ENOG4105CAT	Cytidine monophosphate kinase
IR04_14745	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
IR04_14750	ENOG4105EIN	peptidylprolyl cis-trans isomerase
IR04_14755	ENOG4105K70	DNA-binding protein
IR04_14760	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
IR04_14765	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
IR04_14770	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
IR04_14775	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
IR04_14790	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_14795	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
IR04_14800	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
IR04_14805	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
IR04_14810	ENOG4105CNG	UPF0061 protein
IR04_14825	ENOG4105BZU	Histidine kinase
IR04_14835	ENOG4108HPI	phosphatidate Cytidylyltransferase
IR04_14870	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
IR04_14890	ENOG4105JQN	Transcriptional regulator
IR04_14900	ENOG4107QY8	reductase
IR04_14905	ENOG4105CUW	cytochrome C-TYPE protein
IR04_14910	ENOG410662T	chitinase
IR04_14915	ENOG4105D9N	nucleoside
IR04_14925	ENOG4105JQN	Transcriptional regulator
IR04_14930	ENOG4105CVE	Lytic murein transglycosylase
IR04_14935	ENOG4105VNG	YcgL domain-containing protein
IR04_14940	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
IR04_14945	ENOG4107QMS	site-determining protein
IR04_14950	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
IR04_14975	ENOG4107S74	Lysophospholipid transporter LplT
IR04_14985	ENOG4108N3W	hemolysin secretion protein
IR04_14990	ENOG4108JCI	Transcriptional regulator
IR04_14995	ENOG4105DKK	Benzoate
IR04_15000	ENOG4105CEY	Amp-dependent synthetase and ligase
IR04_15005	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
IR04_15010	ENOG4108IPT	Naphthoate synthase
IR04_15015	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
IR04_15020	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
IR04_15025	ENOG4105E4F	Isochorismate synthase
IR04_15030	ENOG4105CHM	Aminotransferase
IR04_15035	ENOG4105DK2	UPF0207 protein
IR04_15040	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
IR04_15060	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
IR04_15065	ENOG4105CEY	Amp-dependent synthetase and ligase
IR04_15070	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
IR04_15085	ENOG41072GX	Peptidase M22 Glycoprotease
IR04_15090	ENOG4105DVT	helicase
IR04_15100	ENOG4105CIY	formyltetrahydrofolate deformylase
IR04_15105	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
IR04_15110	ENOG4105D07	Signal peptide peptidase, SppA
IR04_15115	ENOG4105HDK	L-asparaginase
IR04_15120	ENOG4105VUT	cytoplasmic protein
IR04_15130	ENOG4105E0X	reductase
IR04_15135	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
IR04_15140	ENOG4105DSB	aldose 1-epimerase
IR04_15150	ENOG4105DHI	Methyltransferase
IR04_15165	ENOG4107R88	Chemotaxis protein (CheV)
IR04_15170	ENOG4105DAG	ROK family
IR04_15175	ENOG4105CA9	Pyruvate kinase
IR04_15180	ENOG4108NRW	Phospholipase, patatin family
IR04_15195	ENOG4105C8J	)-transporter
IR04_15205	ENOG4105CI1	PTS System
IR04_15210	ENOG4105F8V	Hydrolase, tatD family
IR04_15215	ENOG4107QRG	dna polymerase iii
IR04_15220	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
IR04_15225	ENOG4105HHA	aminodeoxychorismate lyase
IR04_15230	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
IR04_15235	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
IR04_15240	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
IR04_15245	ENOG4105CHR	reductase
IR04_15250	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
IR04_15255	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
IR04_15260	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
IR04_15265	ENOG4105VGS	50s ribosomal protein l32
IR04_15270	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
IR04_15275	ENOG4108UHJ	MAF-like protein
IR04_15280	ENOG4105EI2	Pseudouridine synthase
IR04_15290	ENOG4105C03	ribonuclease
IR04_15295	ENOG4105CHH	sulfate transporter
IR04_15305	ENOG4108EKI	Dehydrogenase
IR04_15310	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
IR04_15315	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
IR04_15320	ENOG4105DFD	Na H antiporter
IR04_15330	ENOG4106V8H	Nucleoid-associated protein
IR04_15340	ENOG4105E68	Sulfatase
IR04_15355	ENOG4105DGU	Histone deacetylase
IR04_15360	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
IR04_15365	ENOG4105M2J	Glutaredoxin
IR04_15370	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
IR04_15385	ENOG410903C	(LipO)protein
IR04_15395	ENOG4105KWW	Biogenesis protein
IR04_15400	ENOG4107QX9	Thiol disulfide interChange protein
IR04_15405	ENOG4105DA4	cytochrome c-type biogenesis protein
IR04_15410	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
IR04_15415	ENOG41067VX	Heme exporter protein
IR04_15420	ENOG41060IM	Heme exporter protein
IR04_15425	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
IR04_15430	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
IR04_15440	ENOG4108V3W	Chemotaxis protein, CheW
IR04_15450	ENOG4107QJE	Chromosome Partitioning Protein
IR04_15455	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
IR04_15460	ENOG4105CBS	Chea signal transduction histidine kinase
IR04_15465	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
IR04_15470	ENOG4108VYJ	response regulator receiver protein
IR04_15475	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
IR04_15480	ENOG4107R21	site-determining protein
IR04_15485	ENOG4105FZW	flagellar biosynthesis regulator FlhF
IR04_15490	ENOG4105D7B	Flagellar biosynthesis protein flha
IR04_15495	ENOG4108BY2	phosphohistidine phosphatase
IR04_15500	ENOG4108JQM	Insulinase (Peptidase family M16)
IR04_15510	ENOG4105C75	arginyL-tRNA synthetase
IR04_15530	ENOG4105XFK	Ferrous iron transport protein A
IR04_15535	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
IR04_15540	ENOG4105NXV	High-affinity zinc uptake system protein
IR04_15545	ENOG4105FDK	ABC transporter
IR04_15550	ENOG4105FAV	ABC, transporter
IR04_15555	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
IR04_15560	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
IR04_15565	ENOG4105C7S	Dehydrogenase
IR04_15570	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
IR04_15575	ENOG4105E33	succinate dehydrogenase
IR04_15580	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
IR04_15585	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
IR04_15590	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
IR04_15600	ENOG4105BZN	citrate synthase
IR04_15605	ENOG4107QNR	UPF0135 protein
IR04_15615	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
IR04_15620	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
IR04_15625	ENOG4105EV9	Alpha Beta Hydrolase
IR04_15635	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
IR04_15640	ENOG41067MG	lrgb family
IR04_15645	ENOG4105VAW	lrga family
IR04_15650	ENOG4105CMU	LysR family (Transcriptional regulator
IR04_15660	ENOG41090R7	Ferric uptake
IR04_15665	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
IR04_15670	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
IR04_15675	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
IR04_15680	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
IR04_15685	ENOG4105Q8W	reductase
IR04_15690	ENOG4105MH2	YfcL protein
IR04_15695	ENOG4108BPE	-transporting atpase
IR04_15700	ENOG4105EN6	Membrane
IR04_15705	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
IR04_15710	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
IR04_15720	ENOG4105D00	flagellar biosynthetic protein flhB
IR04_15725	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
IR04_15730	ENOG4105VS8	Flagellar biosynthetic protein fliq
IR04_15735	ENOG4105CN7	Flagellar biosynthetic protein FliP
IR04_15740	ENOG4105VTB	flagellar biosynthesis protein fliO
IR04_15745	ENOG4105DD5	Flagellar motor switch protein
IR04_15750	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
IR04_15755	ENOG4105X6C	Flagellar basal body-associated protein FliL
IR04_15770	ENOG4108JIR	Flagellum-specific ATP synthase
IR04_15775	ENOG4105W2B	Flagellar assembly protein
IR04_15780	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
IR04_15785	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
IR04_15790	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
IR04_15795	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_15800	ENOG4105BZU	Histidine kinase
IR04_15805	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_15810	ENOG4105MQ3	flagellar protein FliS
IR04_15820	ENOG4107W9T	flagellar hook-associated
IR04_15825	ENOG41063QE	flagellar protein FlaG
IR04_15830	ENOG4105I03	Flagellin
IR04_15835	ENOG4105I03	Flagellin
IR04_15840	ENOG4105I03	Flagellin
IR04_15845	ENOG4105EZR	dyp-type peroxidase family protein
IR04_15850	ENOG4105QZU	Inner membrane protein YfeZ
IR04_15865	ENOG4105KUZ	arsenate reductase
IR04_15870	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
IR04_15885	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
IR04_15890	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
IR04_15900	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IR04_15905	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_15920	ENOG4105ERG	peptidase m48, ste24p
IR04_15925	ENOG4105K89	arsenate reductase
IR04_15930	ENOG4105CS1	NAD(P)H quinone oxidoreductase
IR04_15945	ENOG4105C2W	permease
IR04_15950	ENOG4108Z66	YbaK ebsC protein
IR04_15955	ENOG4105CGH	5'-nucleotidase
IR04_15960	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
IR04_15965	ENOG41063JG	Transcriptional regulator
IR04_15970	ENOG4108YY7	Invasion gene expression up-regulator SirB
IR04_15975	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
IR04_15980	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
IR04_15985	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
IR04_15990	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
IR04_15995	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
IR04_16000	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
IR04_16005	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
IR04_16010	ENOG4105C3G	gtp-binding protein
IR04_16095	ENOG4105I03	Flagellin
IR04_16100	ENOG4105I03	Flagellin
IR04_16115	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
IR04_16120	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
IR04_16125	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
IR04_16130	ENOG4105CGA	flagellar basal-body rod protein FlgG
IR04_16135	ENOG4108KPB	Flagellar basal-body rod protein FlgF
IR04_16140	ENOG4105BZE	flagellar hook protein, FlgE
IR04_16145	ENOG4105W00	Flagellar hook capping protein
IR04_16150	ENOG4108ZC9	flagellar basal-body rod protein flgc
IR04_16155	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
IR04_16160	ENOG4105BZU	Histidine kinase
IR04_16165	ENOG4107R88	Chemotaxis protein (CheV)
IR04_16200	ENOG4105C0W	non-ribosomal peptide synthetase
IR04_16205	ENOG4105Q26	Siderophore-interacting protein
IR04_16210	ENOG4107RBR	Receptor
IR04_16220	ENOG4105UYK	outer membrane protein a
IR04_16225	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
IR04_16230	ENOG4105C59	p-type ATPase
IR04_16240	ENOG4105E2D	ec 3.2.1.52
IR04_16245	ENOG4105MBR	gumn family
IR04_16260	ENOG4108DG9	Smr protein MutS2
IR04_16265	ENOG4105FE9	pseudouridine synthase
IR04_16270	ENOG4105BZU	Histidine kinase
IR04_16275	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
IR04_16280	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
IR04_16285	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
IR04_16290	ENOG4105E7A	Glutamine amidotransferase
IR04_16295	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
IR04_16300	ENOG4107QPN	acyl-Coa dehydrogenase
IR04_16310	ENOG4108JDX	DNA polymerase iii, epsilon subunit
IR04_16315	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
IR04_16320	ENOG4105D1A	Methyltransferase
IR04_16325	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
IR04_16330	ENOG4105E9H	Lytic Murein transglycosylase
IR04_16340	ENOG4108YZA	Nitrogen regulatory protein pii
IR04_16345	ENOG4105PY6	Phenolic acid decarboxylase
IR04_16350	ENOG4105N7H	Cytochrome
IR04_16355	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
IR04_16360	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
IR04_16365	ENOG4105C0B	DNA polymerase III (alpha subunit)
IR04_16370	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
IR04_16375	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IR04_16380	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IR04_16385	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
IR04_16390	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IR04_16395	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
IR04_16405	ENOG4105DZP	Membrane-associated zinc metalloprotease
IR04_16410	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
IR04_16415	ENOG4105KNE	Phosphatidate cytidylyltransferase
IR04_16420	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
IR04_16425	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
IR04_16430	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
IR04_16435	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
IR04_16440	ENOG4105CE9	30S ribosomal protein S2
IR04_16445	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
IR04_16450	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
IR04_16455	ENOG4108T8E	UPF0325 protein
IR04_16460	ENOG4108ZAI	phosphatidylglycerophosphatase a
IR04_16465	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
IR04_16470	ENOG4107YIM	Involved in the transcription termination process (By similarity)
IR04_16475	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
IR04_16490	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
IR04_16495	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
IR04_16500	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
IR04_16505	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
IR04_16510	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
IR04_16520	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
IR04_16525	ENOG4105C7N	Xanthine uracil vitamin C permease
IR04_16530	ENOG4105CIN	aminoacyl-histidine dipeptidase
IR04_16535	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
IR04_16540	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
IR04_16550	ENOG4105C8J	)-transporter
IR04_16555	ENOG4105BZU	Histidine kinase
IR04_16580	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
IR04_16590	ENOG4105CJ2	(LipO)protein
IR04_16595	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
IR04_16600	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
IR04_16605	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
IR04_16610	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
IR04_16615	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
IR04_16620	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
IR04_16625	ENOG4105M85	Bola protein
IR04_16630	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
IR04_16640	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
IR04_16645	ENOG4105EYM	Major Facilitator superfamily
IR04_16655	ENOG4105K6V	RNA polymerase
IR04_16665	ENOG4105DRB	nucleoside-specific channel-forming protein
IR04_16670	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
IR04_16675	ENOG4107S0N	DJ-1 family
IR04_16680	ENOG4105C9B	Cysteine desulfurase
IR04_16685	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
IR04_16690	ENOG4105CUZ	uba thif-type nad fad binding protein
IR04_16695	ENOG4105CA3	membrane-bound lytic murein transglycosylase
IR04_16705	ENOG4107QZM	n-acetylglutamate synthase
IR04_16720	ENOG4107QYX	exodeoxyribonuclease v alpha
IR04_16725	ENOG4107QKA	exodeoxyribonuclease V beta
IR04_16730	ENOG4105DSY	exodeoxyribonuclease V, gamma
IR04_16745	ENOG4105X2V	dna damage-inducible protein
IR04_16750	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
IR04_16760	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
IR04_16770	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
IR04_16785	ENOG4108Y51	tRNA-binding protein
IR04_16790	ENOG41060NJ	transcriptional regulator
IR04_16795	ENOG4105CNT	hydrolase family 2
IR04_16805	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
IR04_16810	ENOG4108IQE	Amp-dependent synthetase and ligase
IR04_16815	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
IR04_16820	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
IR04_16830	ENOG4105EAC	phosphoserine phosphatase
IR04_16840	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
IR04_16845	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
IR04_16850	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
IR04_16855	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
IR04_16860	ENOG4105D9N	nucleoside
IR04_16865	ENOG4105EYA	deoxyribonuclease
IR04_16875	ENOG4105BZG	amino acid carrier protein
IR04_16890	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
IR04_16895	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
IR04_16900	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
IR04_16905	ENOG4105D98	threonine synthase
IR04_16910	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
IR04_16925	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
IR04_16935	ENOG41065U4	response regulator
IR04_16940	ENOG4105BZU	Histidine kinase
IR04_16950	ENOG4105N5T	Radical SAM Protein
IR04_16965	ENOG4105CBC	glutamate synthase
IR04_16970	ENOG4105BZ8	glutamate synthase
IR04_16980	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
IR04_16990	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
IR04_16995	ENOG4105EN6	Membrane
IR04_17000	ENOG4105VP0	transcriptional regulator, lysR family
IR04_17005	ENOG4105EJ9	Membrane
IR04_17010	ENOG4107RRE	RNA-directed DNA polymerase
IR04_17035	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
IR04_17040	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
IR04_17050	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
IR04_17055	ENOG4105M6F	mutator MutT protein
IR04_17060	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
IR04_17070	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IR04_17075	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
IR04_17080	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
IR04_17085	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
IR04_17090	ENOG4105DFU	Cell wall formation (By similarity)
IR04_17095	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
IR04_17105	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
IR04_17110	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
IR04_17115	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
IR04_17120	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
IR04_17125	ENOG4105CJN	penicillin-binding protein
IR04_17130	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
IR04_17135	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
IR04_17140	ENOG4107QN2	dihydrolipoyl dehydrogenase
IR04_17145	ENOG4107QSN	dihydrolipoamide acetyltransferase
IR04_17150	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
IR04_17155	ENOG41073TP	transcriptional regulator
IR04_17160	ENOG4105CGH	5'-nucleotidase
IR04_17165	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
IR04_17170	ENOG4105T95	Thiol disulfide interChange protein
IR04_17175	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
IR04_17180	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
IR04_17190	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
IR04_17200	ENOG4107QHF	type ii secretion system protein e
IR04_17205	ENOG4105D7Q	type ii secretion system
IR04_17210	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
IR04_17215	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
IR04_17220	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
IR04_17230	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
IR04_17235	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IR04_17240	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IR04_17245	ENOG4105IPS	esterase
IR04_17250	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
IR04_17255	ENOG4108SX3	cytoplasmic protein
IR04_17260	ENOG41087AY	ADP-Ribose pyrophosphatase
IR04_17265	ENOG4105DFG	type I secretion outer membrane protein
IR04_17275	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
IR04_17280	ENOG4105C8Q	Methyl-accepting chemotaxis
IR04_17290	ENOG4105I7R	Adenylate cyclase
IR04_17295	ENOG4107IX6	phosphate transport regulator
IR04_17300	ENOG4105CJ3	phosphate transporter
IR04_17305	ENOG4106MWK	domain protein
IR04_17320	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
IR04_17325	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
IR04_17330	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
IR04_17340	ENOG4105DXN	mazG family
IR04_17345	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
IR04_17350	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
IR04_17355	ENOG4105BZU	Histidine kinase
IR04_17360	ENOG4108K0B	C-di-gmp phosphodiesterase
IR04_17375	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
IR04_17380	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
IR04_17385	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
IR04_17390	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
IR04_17395	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
IR04_17400	ENOG4105C3F	Signal peptidase i
IR04_17405	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
IR04_17410	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
IR04_17415	ENOG4105VQK	sigma E regulatory protein, MucB RseB
IR04_17425	ENOG4105EMN	RNA polymerase sigma factor
IR04_17430	ENOG4108IYU	L-aspartate oxidase
IR04_17440	ENOG4105Y75	tpr repeat protein
IR04_17445	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
IR04_17455	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
IR04_17460	ENOG4105D0A	hydroxylase
IR04_17470	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
IR04_17480	ENOG4105E66	phosphoriboisomerase A
IR04_17485	ENOG4108JQ1	Dehydrogenase
IR04_17490	ENOG4108ZP8	Acetolactate synthase small subunit
IR04_17495	ENOG4105C7K	acetolactate synthase
IR04_17500	ENOG4108IQE	Amp-dependent synthetase and ligase
IR04_17505	ENOG41064T2	transcriptional regulator, lysR family
IR04_17525	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
IR04_17530	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
IR04_17535	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
IR04_17540	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
IR04_17585	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
IR04_17600	ENOG4108K5H	permease YjgP YjgQ family protein
IR04_17605	ENOG4108M8S	permease YjgP YjgQ family protein
IR04_17610	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
IR04_17615	ENOG4105MYG	DNA polymerase iii, chi subunit
IR04_17620	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
IR04_17625	ENOG4105C5I	Dehydrogenase
IR04_17630	ENOG4105D3G	Pseudouridine synthase
IR04_17635	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
IR04_17645	ENOG4108IAB	Phoh family
IR04_17650	ENOG4105DBV	ornithine carbamoyltransferase
IR04_17660	ENOG4105CXT	aspartate transcarbamylase
IR04_17665	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
IR04_17670	ENOG4105KME	endoribonuclease L-psp
IR04_17675	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
IR04_17680	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
IR04_17685	ENOG4105VFK	BolA family
IR04_17695	ENOG4105E3I	toluene tolerance
IR04_17700	ENOG4107PE3	Mammalian cell entry related domain protein
IR04_17705	ENOG4105CY3	ABC transporter, permease
IR04_17710	ENOG4105DHJ	ABC, transporter
IR04_17720	ENOG4105C2X	Arabinose 5-phosphate isomerase
IR04_17725	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
IR04_17735	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
IR04_17740	ENOG4108IUZ	ABC transporter
IR04_17745	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
IR04_17750	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
IR04_17755	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
IR04_17760	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
IR04_17765	ENOG41080Z8	PHOSPHOCARRIER protein
IR04_17770	ENOG4105CJW	magnesium transporter
IR04_17775	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
IR04_17780	ENOG4105N42	UPF0307 protein
IR04_17785	ENOG4107T0D	ABC, transporter
IR04_17790	ENOG4106SMU	thiamine transporter membrane protein
IR04_17795	ENOG4105DP9	ABC transporter
IR04_17800	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
IR04_17805	ENOG4105DFU	Cell wall formation (By similarity)
IR04_17810	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IR04_17815	ENOG4105F0N	pyrophosphate phospho-hydrolase
IR04_17820	ENOG41066HZ	AIG2-like family
IR04_17830	ENOG4105CFU	surface antigen
IR04_17835	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
IR04_17840	ENOG4108UUE	Transcriptional regulator
IR04_17855	ENOG4105C19	ABC transporter
IR04_17875	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
IR04_17880	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
IR04_17885	ENOG4105C11	sulfate adenylyltransferase), subunit 2
IR04_17890	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
IR04_17895	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
IR04_17905	ENOG4105C1J	atp-dependent rna helicase
IR04_17910	ENOG4107YB6	acetyltransferase, (GNAT) family
IR04_17915	ENOG4108SXK	Transporter Drug Metabolite Exporter family
IR04_17925	ENOG4108V1T	peptidylprolyl cis-trans isomerase
IR04_17935	ENOG4108ZT0	50S ribosomal protein l17
IR04_17940	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IR04_17945	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
IR04_17950	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
IR04_17955	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IR04_17965	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
IR04_17970	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
IR04_17975	ENOG4105VPB	50S ribosomal protein L30
IR04_17980	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
IR04_17985	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
IR04_17990	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
IR04_17995	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
IR04_18000	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
IR04_18005	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IR04_18010	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
IR04_18015	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
IR04_18020	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
IR04_18025	ENOG41083MP	50s ribosomal protein l29
IR04_18030	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
IR04_18035	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
IR04_18040	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
IR04_18045	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
IR04_18050	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IR04_18055	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
IR04_18060	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
IR04_18065	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
IR04_18070	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
IR04_18080	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
IR04_18085	ENOG4105E68	Sulfatase
IR04_18090	ENOG4108UV7	flagellar protein motX
IR04_18095	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
IR04_18100	ENOG4105D44	asparaginase
IR04_18105	ENOG4108YZY	peptidylprolyl cis-trans isomerase
IR04_18120	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
IR04_18125	ENOG4105C5H	ABC transporter
IR04_18135	ENOG4105DNZ	Alpha Beta Hydrolase
IR04_18145	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
IR04_18150	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
IR04_18170	ENOG4105C8Y	Acetylornithine aminotransferase
IR04_18175	ENOG4105DDQ	anthranilate synthase
IR04_18180	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
IR04_18195	ENOG4105C31	Tryptophanyl-tRNA synthetase
IR04_18200	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
IR04_18205	ENOG4105DJV	ribulose-phosphate 3-epimerase
IR04_18210	ENOG4105DFE	Dna adenine methylase
IR04_18220	ENOG4105D49	3-dehydroquinate synthase
IR04_18225	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
IR04_18230	ENOG4105E4G	Type IV pilus
IR04_18255	ENOG4108JQC	penicillin-binding protein 1A
IR04_18265	ENOG4105EHV	domain protein
IR04_18270	ENOG4107QN2	dihydrolipoyl dehydrogenase
IR04_18280	ENOG4105CH7	arginosuccinase
IR04_18285	ENOG4105CDH	Citrulline--aspartate ligase
IR04_18290	ENOG4105CAS	nag kinase
IR04_18295	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
IR04_18300	ENOG4105CWC	Acetylornithine deacetylase
IR04_18305	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
IR04_18315	ENOG4105D7W	serine acetyltransferase
IR04_18320	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
IR04_18325	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
IR04_18330	ENOG4107YZP	Rhodanese domain protein
IR04_18335	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
IR04_18345	ENOG4105E33	succinate dehydrogenase
IR04_18350	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
IR04_18355	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
IR04_18360	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
IR04_18365	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
IR04_18375	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
IR04_18380	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
IR04_18405	ENOG4105CP7	Triose-phosphate isomerase
IR04_18415	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
IR04_18420	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
IR04_18425	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
IR04_18430	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
IR04_18435	ENOG41063M6	Cell Division Protein
IR04_18440	ENOG4105ETE	Transcriptional regulator (LacI family
IR04_18445	ENOG4105C25	Primosomal protein n'
IR04_18450	ENOG4105VFB	Binds the 23S rRNA (By similarity)
IR04_18455	ENOG4105C6K	Malic enzyme
IR04_18460	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
IR04_18465	ENOG4105C28	cystathionine
IR04_18470	ENOG4105CFH	Aspartokinase
IR04_18480	ENOG4105SYT	Methylenetetrahydrofolate reductase
IR04_18485	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
IR04_18490	ENOG4105CBT	Fructose-1,6-bisphosphatase
IR04_18495	ENOG4105CTQ	phosphohexokinase
IR04_18500	ENOG41076HS	cation diffusion facilitator family transporter
IR04_18510	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
IR04_18515	ENOG4105E0F	Histidine kinase
IR04_18525	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
IR04_18530	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
IR04_18535	ENOG4105BZU	Histidine kinase
IR04_18540	ENOG4108IJ0	Aspartate ammonia-lyase
IR04_18545	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
IR04_18560	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
IR04_18570	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
IR04_18580	ENOG4107QN1	sodium solute
IR04_18585	ENOG4105EX9	Membrane
IR04_18590	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
IR04_18595	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
IR04_18600	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
IR04_18605	ENOG4105CB5	ATP-dependent DNA helicase recG
IR04_18610	ENOG4105C2W	permease
IR04_18620	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
IR04_18625	ENOG4108RRZ	Transcription elongation factor GreB
IR04_18630	ENOG4105BZM	domain protein
IR04_18640	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
IR04_18645	ENOG4105MJ2	Competence protein
IR04_18650	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
IR04_18655	ENOG4107RK2	ADP-ribose diphosphatase NudE
IR04_18660	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
IR04_18665	ENOG4105PIC	general secretion pathway protein N
IR04_18670	ENOG4105U1E	general secretion pathway protein M
IR04_18675	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
IR04_18680	ENOG4108RTD	type II secretion system protein K
IR04_18685	ENOG4108WWZ	General secretion pathway protein J
IR04_18690	ENOG4105X5Z	General secretion pathway protein I
IR04_18695	ENOG4105VWV	general secretion pathway protein h
IR04_18700	ENOG4108VAU	general secretion pathway protein G
IR04_18705	ENOG4105D7Q	type ii secretion system
IR04_18710	ENOG4107QHF	type ii secretion system protein e
IR04_18720	ENOG4108XKW	General secretion pathway protein C
IR04_18725	ENOG4105VEJ	Heat shock protein
IR04_18730	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
IR04_18735	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
IR04_18745	ENOG4105SUU	thioesterase domain
IR04_18750	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
IR04_18775	ENOG4105C5F	glutamine synthetase
IR04_18790	ENOG4105CUX	Signal transduction histidine kinase
IR04_18795	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IR04_18800	ENOG4105BZU	Histidine kinase
IR04_18805	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
IR04_18870	ENOG4108RR8	protoporphyrinogen oxidase
IR04_18875	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
IR04_18880	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
IR04_18885	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
IR04_18890	ENOG4105CHU	acetyl-coa acetyltransferase
IR04_18895	ENOG4105F52	Transcriptional regulator
IR04_18900	ENOG4105CZQ	inner membrane transport protein YdhC
IR04_18905	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
IR04_18910	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
IR04_18915	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
IR04_18920	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
IR04_18925	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
IR04_18930	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
IR04_18935	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
IR04_18940	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
IR04_18945	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
IR04_18950	ENOG410684E	atp synthase
IR04_18955	ENOG4105FA0	parb-like partition protein
IR04_18960	ENOG4107QJE	Chromosome Partitioning Protein
IR04_18965	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
IR04_18970	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)