locus-tag	class	description
C4E16_00005	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
C4E16_00010	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4E16_00015	ENOG4105DJ0	Poly(A) Polymerase
C4E16_00020	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
C4E16_00025	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4E16_00030	ENOG4105PW4	Sugar fermentation stimulation protein homolog
C4E16_00040	ENOG4105CQ7	ATP-dependent helicase
C4E16_00045	ENOG4105BZ4	penicillin-binding protein
C4E16_00050	ENOG4105D78	K07001 NTE family protein
C4E16_00055	ENOG4107QIJ	Aconitate hydratase 2
C4E16_00060	ENOG4105XTV	UPF0231 protein
C4E16_00065	ENOG4108YZA	Nitrogen regulatory protein pii
C4E16_00085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
C4E16_00095	ENOG4105E2V	Glycosyltransferase 36
C4E16_00100	ENOG4105E2D	ec 3.2.1.52
C4E16_00105	ENOG4105RD7	BadF BadG BcrA BcrD
C4E16_00115	ENOG4108JQ7	(ABC) transporter
C4E16_00120	ENOG4105C3U	ABC transporter
C4E16_00125	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
C4E16_00135	ENOG4107QRA	Extracellular solute-binding protein, family 5
C4E16_00145	ENOG4105BZU	Histidine kinase
C4E16_00150	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
C4E16_00155	ENOG4105IPI	Membrane
C4E16_00160	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
C4E16_00165	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
C4E16_00180	ENOG4105DR5	peptidase
C4E16_00185	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
C4E16_00190	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
C4E16_00195	ENOG4105FCK	Membrane
C4E16_00200	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
C4E16_00205	ENOG4105HBR	Rna-binding protein
C4E16_00210	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
C4E16_00215	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C4E16_00220	ENOG4105EEI	dihydropteroate synthase
C4E16_00225	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
C4E16_00250	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
C4E16_00255	ENOG4105CHV	Transcription elongation factor NusA
C4E16_00260	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
C4E16_00265	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
C4E16_00270	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
C4E16_00275	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
C4E16_00280	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
C4E16_00285	ENOG4105RT1	May be involved in cell division (By similarity)
C4E16_00300	ENOG4106RZ4	Peptidase U32
C4E16_00305	ENOG4105CFP	Peptidase U32
C4E16_00310	ENOG4105BZU	Histidine kinase
C4E16_00315	ENOG4105XPQ	lipid carrier protein
C4E16_00320	ENOG4108YYD	acetyltransferase
C4E16_00335	ENOG4105BZU	Histidine kinase
C4E16_00340	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
C4E16_00425	ENOG4108R0M	Aminoglycoside
C4E16_00535	ENOG4105T95	Thiol disulfide interChange protein
C4E16_00590	ENOG4105RWS	endonuclease I
C4E16_00605	ENOG4108UUM	single-stranded DNA-binding protein
C4E16_00620	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
C4E16_00645	ENOG4108YGG	dna repair protein
C4E16_00670	ENOG4108KB1	transcriptional regulator, arac family
C4E16_00755	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
C4E16_00760	ENOG4105C1J	atp-dependent rna helicase
C4E16_00765	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
C4E16_00770	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
C4E16_00780	ENOG4105CRK	lysyL-tRNA synthetase
C4E16_00785	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_00795	ENOG4105CPC	Aldo Keto reductase
C4E16_00800	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
C4E16_00805	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
C4E16_00810	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
C4E16_00815	ENOG4105HF0	Membrane
C4E16_00820	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
C4E16_00825	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
C4E16_00835	ENOG41063Z6	transcriptional regulator, lysR family
C4E16_00840	ENOG41080HT	Transcriptional regulator, arsr family
C4E16_00845	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
C4E16_00850	ENOG4105CJR	Integral membrane protein (MviN
C4E16_00855	ENOG4105DTN	riboflavin biosynthesis protein ribF
C4E16_00860	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
C4E16_00865	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
C4E16_00870	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
C4E16_00875	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
C4E16_00895	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4E16_00900	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
C4E16_00905	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
C4E16_00910	ENOG4108NEV	two component transcriptional regulator, LytTR family
C4E16_00915	ENOG4108HRK	Histidine kinase
C4E16_00920	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
C4E16_00935	ENOG4105C5H	ABC transporter
C4E16_00940	ENOG4107SC1	transglycosylase
C4E16_00945	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
C4E16_00950	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
C4E16_00955	ENOG4108K0B	C-di-gmp phosphodiesterase
C4E16_00960	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
C4E16_00970	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
C4E16_00975	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4E16_00980	ENOG4105C34	Pseudouridine synthase
C4E16_00985	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
C4E16_00990	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C4E16_01030	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
C4E16_01035	ENOG4105CFP	Peptidase U32
C4E16_01040	ENOG4105DH7	May be involved in recombination (By similarity)
C4E16_01045	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C4E16_01050	ENOG4105BZU	Histidine kinase
C4E16_01060	ENOG4105C9X	ppx gppa phosphatase
C4E16_01065	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
C4E16_01070	ENOG4105C8U	phosphate abc transporter
C4E16_01075	ENOG4105E2Z	phosphate ABC transporter (Permease
C4E16_01080	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C4E16_01090	ENOG4105CSR	polyphosphate kinase 2
C4E16_01095	ENOG4106N3A	copper homeostasis protein cutc
C4E16_01100	ENOG4105D3R	alkyl hydroperoxide reductase
C4E16_01105	ENOG4105C5Q	Transcriptional regulator
C4E16_01110	ENOG4107QP3	malate synthase g
C4E16_01115	ENOG4108I9X	Isocitrate lyase
C4E16_01120	ENOG4105W87	Cbs domain
C4E16_01125	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
C4E16_01135	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
C4E16_01140	ENOG4105VIE	preprotein translocase, subunit YajC
C4E16_01145	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C4E16_01150	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C4E16_01155	ENOG4105ECY	inositol monophosphatase
C4E16_01160	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
C4E16_01165	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
C4E16_01170	ENOG4105C3J	Cysteine desulfurase
C4E16_01175	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
C4E16_01180	ENOG4108Z4V	iron-sulfur cluster assembly
C4E16_01185	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
C4E16_01190	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
C4E16_01195	ENOG4108ZIT	Ferredoxin, 2FE-2S
C4E16_01200	ENOG4105WVQ	Fe-S assembly protein IscX
C4E16_01205	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
C4E16_01210	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
C4E16_01215	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
C4E16_01225	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
C4E16_01230	ENOG4105CUT	histidyl-tRNA synthetase
C4E16_01235	ENOG4105N21	Membrane
C4E16_01240	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
C4E16_01245	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
C4E16_01260	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C4E16_01265	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
C4E16_01270	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
C4E16_01280	ENOG4106HK8	GPR1 FUN34 yaaH family protein
C4E16_01285	ENOG4105WQI	isochorismatase
C4E16_01290	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
C4E16_01295	ENOG4105E4F	Isochorismate synthase
C4E16_01300	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
C4E16_01310	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
C4E16_01315	ENOG4105DQ5	transport system permease protein
C4E16_01320	ENOG4105TVJ	transport system, permease
C4E16_01325	ENOG4105E0A	ABC, transporter
C4E16_01335	ENOG41064T2	transcriptional regulator, lysR family
C4E16_01340	ENOG4105EUZ	Beta-lactamase domain protein
C4E16_01345	ENOG4105BZG	amino acid carrier protein
C4E16_01350	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
C4E16_01370	ENOG4106YYS	transcriptional regulatory protein
C4E16_01375	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
C4E16_01380	ENOG4105D9Q	decarboxylase (Beta subunit)
C4E16_01385	ENOG4107QSA	Oxaloacetate decarboxylase
C4E16_01400	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
C4E16_01405	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
C4E16_01410	ENOG4105CI0	Citrate lyase
C4E16_01415	ENOG4105CHY	citrate lyase, alpha
C4E16_01420	ENOG4105YGP	holo-ACP synthase CitX
C4E16_01425	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
C4E16_01440	ENOG4108Z4U	Ferredoxin
C4E16_01445	ENOG4105DZ0	fad dependent oxidoreductase
C4E16_01510	ENOG4105C26	Dehydrogenase
C4E16_01530	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
C4E16_01535	ENOG4107RK6	Methyl-accepting chemotaxis
C4E16_01550	ENOG4105XB6	Toxin coregulated pilin
C4E16_01565	ENOG4105GRU	toxin co-regulated pilus biosynthesis outer membrane protein C
C4E16_01585	ENOG4107QHF	type ii secretion system protein e
C4E16_01590	ENOG4108VEY	type ii secretion system
C4E16_01605	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
C4E16_01610	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_01625	ENOG4105DR5	peptidase
C4E16_01635	ENOG4105F88	accessory colonization factor AcfD
C4E16_01640	ENOG4105DFP	Integrase
C4E16_01650	ENOG4105DFP	Integrase
C4E16_01660	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
C4E16_01665	ENOG4108Z1B	Cyclase dehydrase
C4E16_01670	ENOG4105VDB	UPF0125 protein
C4E16_01675	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
C4E16_01680	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
C4E16_01685	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
C4E16_01690	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4E16_01695	ENOG4105CFG	Acts as a chaperone (By similarity)
C4E16_01700	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
C4E16_01710	ENOG4106855	Competence protein
C4E16_01735	ENOG4105CFC	Transporter
C4E16_01740	ENOG4108Z6B	deaminase
C4E16_01745	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
C4E16_01755	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
C4E16_01760	ENOG4108RS6	transposase
C4E16_01785	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
C4E16_01790	ENOG4108R96	Methyltransferase, YaeB family
C4E16_01795	ENOG4105NRA	50s ribosomal protein l31 type b
C4E16_01805	ENOG4105CFC	Transporter
C4E16_01810	ENOG4108UPT	UPF0178 protein
C4E16_01820	ENOG4108428	Inherit from COG: -acetyltransferase
C4E16_01835	ENOG4105WP7	tRNA pseudouridine synthase C
C4E16_01840	ENOG4105DR9	pseudouridine synthase
C4E16_01845	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
C4E16_01850	ENOG4105CTB	Polyprenyl synthetase
C4E16_01860	ENOG4105E14	MotA TolQ exbB proton channel
C4E16_01865	ENOG4106VK6	Flagellar motor protein
C4E16_01870	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
C4E16_01875	ENOG4105ETT	transcriptional Regulator, LysR family
C4E16_01880	ENOG4105M08	Membrane
C4E16_01885	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
C4E16_01890	ENOG4105EWT	decarboxylase family
C4E16_01895	ENOG4105BZU	Histidine kinase
C4E16_01905	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
C4E16_01910	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
C4E16_01915	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
C4E16_01920	ENOG4105D01	(LipO)protein
C4E16_01925	ENOG4108UMI	ABC transporter, permease
C4E16_01930	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
C4E16_01935	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
C4E16_01940	ENOG4105D4X	repressor
C4E16_01945	ENOG4105C5Y	PTS System
C4E16_01950	ENOG4105CG3	alpha amylase, catalytic region
C4E16_01965	ENOG4105BZS	acriflavin resistance protein
C4E16_01970	ENOG4107ZF2	Phosphatase
C4E16_01975	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
C4E16_01985	ENOG4108UW5	maltose o-acetyltransferase
C4E16_02005	ENOG4105D7W	serine acetyltransferase
C4E16_02015	ENOG4105Q84	sucrose synthase
C4E16_02025	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
C4E16_02040	ENOG4108MA4	Peptidase M66
C4E16_02055	ENOG4105D3Q	Sugar transferase
C4E16_02065	ENOG4105DAY	polysaccharide export protein
C4E16_02070	ENOG4105D75	Capsular exopolysaccharide family
C4E16_02090	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
C4E16_02100	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
C4E16_02105	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
C4E16_02110	ENOG4108Z43	UPF0250 protein
C4E16_02115	ENOG4105DZ1	carboxypeptidase
C4E16_02120	ENOG4105K6T	rare lipoprotein A
C4E16_02125	ENOG4105CNI	cell division protein FtsW
C4E16_02130	ENOG4105CJN	penicillin-binding protein
C4E16_02135	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
C4E16_02140	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
C4E16_02145	ENOG4105DJF	DNA polymerase III, delta' subunit
C4E16_02150	ENOG4108U2H	Rare lipoprotein B
C4E16_02155	ENOG4105C8T	Leucyl-tRNA synthetase
C4E16_02160	ENOG4107PAI	alpha helical protein
C4E16_02165	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
C4E16_02170	ENOG4108JU5	Magnesium and cobalt efflux protein
C4E16_02175	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
C4E16_02180	ENOG4105C9A	Phoh family
C4E16_02185	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
C4E16_02190	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
C4E16_02195	ENOG4105C5Y	PTS System
C4E16_02205	ENOG4105KZ7	phosphocarrier protein hpr
C4E16_02215	ENOG4105C6T	cysteine synthase
C4E16_02220	ENOG4105EXN	Sulfate transport protein CysZ
C4E16_02225	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
C4E16_02230	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
C4E16_02240	ENOG41081QG	Porin Gram-negative type
C4E16_02250	ENOG4108Z6Z	Transcriptional regulator
C4E16_02255	ENOG4105G5H	Membrane
C4E16_02260	ENOG4107QX8	SPFH domain, Band 7 family protein
C4E16_02270	ENOG4107QR8	Thioredoxin
C4E16_02280	ENOG4105E1F	short-chain dehydrogenase reductase
C4E16_02285	ENOG4105ECP	epimerase
C4E16_02290	ENOG4108RE9	Phosphodiesterase
C4E16_02305	ENOG4108TU9	TRANSCRIPTIONal
C4E16_02310	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
C4E16_02315	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
C4E16_02320	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
C4E16_02325	ENOG4105DUX	Transporter
C4E16_02330	ENOG4105MDZ	Transcriptional activator rfaH
C4E16_02335	ENOG4105CAQ	asparagine synthetase
C4E16_02340	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
C4E16_02345	ENOG4105E2R	ROK family
C4E16_02350	ENOG4105CE4	GlcNAc 6-P deacetylase
C4E16_02355	ENOG4105CI1	PTS System
C4E16_02360	ENOG4105CX6	glutaminyL-tRNA synthetase
C4E16_02370	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
C4E16_02375	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
C4E16_02380	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
C4E16_02385	ENOG4108S3P	Sporulation domain protein
C4E16_02390	ENOG4105E96	Colicin v production protein
C4E16_02395	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
C4E16_02400	ENOG4105D3Y	Na H antiporter
C4E16_02405	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
C4E16_02410	ENOG4105EIY	sodium-type flagellar protein motY
C4E16_02415	ENOG4106WH9	Protein of unknown function (DUF2753)
C4E16_02420	ENOG4108UYE	Lactoylglutathione lyase
C4E16_02425	ENOG4105CSM	endonuclease III
C4E16_02430	ENOG4105DZB	Electron transport complex
C4E16_02435	ENOG4108UQQ	Electron transport complex
C4E16_02440	ENOG4105D6A	Electron transport complex
C4E16_02450	ENOG4108R3D	Electron transport complex
C4E16_02465	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
C4E16_02475	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_02485	ENOG4105CHW	UPF0052 protein
C4E16_02490	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C4E16_02495	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
C4E16_02500	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C4E16_02505	ENOG4105M00	molybdopterin converting factor, subunit 1
C4E16_02510	ENOG4108ZAF	Molybdopterin
C4E16_02515	ENOG4105BZU	Histidine kinase
C4E16_02535	ENOG4108I5U	Uridine phosphorylase
C4E16_02545	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
C4E16_02550	ENOG4105D1F	ATP-binding protein
C4E16_02560	ENOG4105DBI	uridine monophosphokinase
C4E16_02565	ENOG4108GAE	asmA family
C4E16_02570	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
C4E16_02580	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
C4E16_02585	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
C4E16_02605	ENOG4105CHU	acetyl-coa acetyltransferase
C4E16_02610	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
C4E16_02615	ENOG41069NU	Nitroreductase
C4E16_02620	ENOG4105EJC	lysr family transcriptional regulator
C4E16_02625	ENOG4105I93	response regulator
C4E16_02635	ENOG4105WD1	Membrane
C4E16_02640	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
C4E16_02645	ENOG4107QMP	dna polymerase iii subunits gamma and tau
C4E16_02650	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
C4E16_02655	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
C4E16_02660	ENOG4105KRS	Proteinase inhibitor
C4E16_02670	ENOG4105UBK	short-chain dehydrogenase reductase
C4E16_02675	ENOG4105ERU	peptidase
C4E16_02685	ENOG4108XM1	transcriptional regulator AsnC family
C4E16_02690	ENOG4105C29	acyl-CoA thioesterase
C4E16_02710	ENOG4105BZU	Histidine kinase
C4E16_02720	ENOG41082YX	Transcriptional regulator, arsr family
C4E16_02725	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
C4E16_02750	ENOG4108V1U	phospholipid-binding protein
C4E16_02770	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C4E16_02785	ENOG4107YTP	response regulator receiver protein
C4E16_02795	ENOG4105BZU	Histidine kinase
C4E16_02800	ENOG4105BZU	Histidine kinase
C4E16_02805	ENOG4105BZU	Histidine kinase
C4E16_02810	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_02825	ENOG4107QSI	ABC, transporter
C4E16_02830	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
C4E16_02835	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
C4E16_02840	ENOG4105C3U	ABC transporter
C4E16_02845	ENOG4108JQ7	(ABC) transporter
C4E16_02850	ENOG4105CHF	Glutathione S-transferase
C4E16_02855	ENOG4108DNC	Involved in acetate metabolism (By similarity)
C4E16_02860	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
C4E16_02865	ENOG4105PQ6	UPF0208 membrane protein
C4E16_02870	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
C4E16_02880	ENOG4105C7J	ABC transporter, permease
C4E16_02885	ENOG4108JJB	ABC transporter
C4E16_02890	ENOG4105BZU	Histidine kinase
C4E16_02895	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
C4E16_02900	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
C4E16_02910	ENOG4105D1H	recombination factor protein RarA
C4E16_02915	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
C4E16_02920	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
C4E16_02925	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
C4E16_02930	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
C4E16_02935	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
C4E16_02940	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
C4E16_02950	ENOG4105D0M	Protease HtpX homolog
C4E16_02960	ENOG4107FW0	short-chain dehydrogenase reductase
C4E16_02975	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
C4E16_02985	ENOG4105RHG	
C4E16_02995	ENOG4107QTF	adenylosuccinate lyase
C4E16_03000	ENOG41075W9	High frequency lysogenization protein HflD homolog
C4E16_03005	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
C4E16_03010	ENOG4107RE1	Inosine-guanosine kinase
C4E16_03020	ENOG4107S6Z	Na H antiporter
C4E16_03025	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
C4E16_03030	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
C4E16_03035	ENOG4105CIH	Imidazole acetol-phosphate transaminase
C4E16_03040	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
C4E16_03045	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
C4E16_03050	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
C4E16_03055	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
C4E16_03060	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
C4E16_03065	ENOG4108R99	pseudouridine synthase
C4E16_03075	ENOG4105VEQ	Cold shock protein
C4E16_03080	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
C4E16_03085	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C4E16_03095	ENOG41090BQ	Glutaredoxin
C4E16_03100	ENOG4108EKI	Dehydrogenase
C4E16_03105	ENOG4106KNT	transcriptional regulator
C4E16_03110	ENOG4105DY8	decarboxylase
C4E16_03120	ENOG4105DWU	Membrane
C4E16_03145	ENOG4105CUX	Signal transduction histidine kinase
C4E16_03155	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
C4E16_03175	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
C4E16_03180	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
C4E16_03185	ENOG41081XQ	Conserved Protein
C4E16_03190	ENOG4105C9M	aspartyl-trna synthetase
C4E16_03195	ENOG4107104	thymidine kinase
C4E16_03200	ENOG4105CK2	sodium dicarboxylate symporter
C4E16_03205	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
C4E16_03210	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
C4E16_03215	ENOG4105DK0	Indole-3-glycerol phosphate synthase
C4E16_03220	ENOG4108I0Q	anthranilate phosphoribosyltransferase
C4E16_03225	ENOG4105DDQ	anthranilate synthase
C4E16_03230	ENOG4105CRQ	synthase (Component I)
C4E16_03240	ENOG4105DB7	PHP domain protein
C4E16_03245	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
C4E16_03250	ENOG4105FE9	pseudouridine synthase
C4E16_03255	ENOG4108JJ8	(ABC) transporter
C4E16_03260	ENOG4108JJ9	ABC, transporter
C4E16_03265	ENOG4105C3M	thioredoxin reductase
C4E16_03275	ENOG4105C9B	Cysteine desulfurase
C4E16_03280	ENOG4105BZU	Histidine kinase
C4E16_03285	ENOG4107GZ4	SanA protein
C4E16_03295	ENOG4107R1I	NAD-dependent malic enzyme
C4E16_03305	ENOG4105C8V	SAICAR synthetase
C4E16_03325	ENOG4108ZG0	Ompa motb domain protein
C4E16_03340	ENOG4105CQB	FAD linked oxidase domain protein
C4E16_03350	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
C4E16_03360	ENOG4105C84	Histidine ammonia-lyase
C4E16_03365	ENOG4105CGP	Urocanate hydratase
C4E16_03370	ENOG41088SP	formiminoglutamate hydrolase
C4E16_03375	ENOG4105CI2	imidazolone-5-propionate hydrolase
C4E16_03380	ENOG4105CZE	histidine utilization repressor
C4E16_03395	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
C4E16_03405	ENOG4105BZU	Histidine kinase
C4E16_03410	ENOG4105CQ2	DNA polymerase
C4E16_03415	ENOG4105WH1	Two component transcriptional regulator luxr family
C4E16_03420	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
C4E16_03450	ENOG4105BZU	Histidine kinase
C4E16_03460	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
C4E16_03465	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
C4E16_03470	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
C4E16_03485	ENOG4105FQ6	thiopurine methyltransferase
C4E16_03505	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
C4E16_03510	ENOG41067MG	lrgb family
C4E16_03520	ENOG4105CJB	Exodeoxyribonuclease I
C4E16_03525	ENOG4108ETY	sodium dicarboxylate symporter
C4E16_03530	ENOG4105E0X	reductase
C4E16_03540	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
C4E16_03545	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
C4E16_03550	ENOG4108YZT	Adenosylcobinamide kinase
C4E16_03565	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
C4E16_03570	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
C4E16_03585	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_03615	ENOG4107QK7	reductase
C4E16_03620	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C4E16_03625	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C4E16_03630	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
C4E16_03635	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4E16_03640	ENOG4105C72	UPF0176 protein
C4E16_03650	ENOG4105S8Q	sugar efflux transporter
C4E16_03660	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
C4E16_03685	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
C4E16_03690	ENOG4105EAQ	(twin-arginine translocation) pathway signal
C4E16_03695	ENOG4105C5X	domain protein
C4E16_03710	ENOG4105CH5	extracellular solute-binding protein, family 7
C4E16_03720	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
C4E16_03740	ENOG41067TZ	transcriptional regulator, MarR family
C4E16_03745	ENOG4105C94	Transporter
C4E16_03755	ENOG4105VZJ	PTS System
C4E16_03765	ENOG4105VCP	PTS System
C4E16_03770	ENOG4105F8D	glycoside hydrolase family 4
C4E16_03775	ENOG410901P	UPF0249 protein
C4E16_03780	ENOG41060NJ	transcriptional regulator
C4E16_03785	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
C4E16_03790	ENOG4105DJ9	glucan biosynthesis protein
C4E16_03795	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_03810	ENOG4105CGF	Aromatic amino acid aminotransferase
C4E16_03820	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C4E16_03830	ENOG4105C5S	asparaginyl-tRNA synthetase
C4E16_03835	ENOG4108NVR	Methyl-accepting chemotaxis
C4E16_03840	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
C4E16_03845	ENOG4105EJQ	L-serine dehydratase
C4E16_03850	ENOG4105C44	Serine transporter
C4E16_03855	ENOG4105P8F	nudix hydrolase
C4E16_03860	ENOG4105CRQ	synthase (Component I)
C4E16_03875	ENOG4105CM6	amino acid regulated cytosolic protein
C4E16_03885	ENOG4108JU8	Transcriptional regulator
C4E16_03890	ENOG4105D9U	N-acetyltransferase
C4E16_03910	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C4E16_03915	ENOG4108NVR	Methyl-accepting chemotaxis
C4E16_03920	ENOG4105C8P	)-transporter
C4E16_03925	ENOG4105BZU	Histidine kinase
C4E16_03930	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_03935	ENOG4108MJ5	VirK protein
C4E16_03940	ENOG4105RW8	MltA-interacting MipA family protein
C4E16_03945	ENOG4105EB3	Histidine kinase
C4E16_03950	ENOG4107EXC	regulatoR
C4E16_03980	ENOG4105C2J	ABC transporter
C4E16_03985	ENOG4107SDZ	Galactoside transport system permease protein mglC
C4E16_04015	ENOG41073TP	transcriptional regulator
C4E16_04020	ENOG4105CR4	methylisocitrate lyase
C4E16_04025	ENOG4105BZN	citrate synthase
C4E16_04030	ENOG4108I0Z	Aconitate hydratase
C4E16_04035	ENOG4105C7F	AcnD-accessory protein PrpF
C4E16_04040	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
C4E16_04055	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
C4E16_04060	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
C4E16_04065	ENOG4105F1J	Homogentisate 1,2-dioxygenase
C4E16_04075	ENOG4108RXX	maleylacetoacetate isomerase
C4E16_04080	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C4E16_04085	ENOG4105BZU	Histidine kinase
C4E16_04100	ENOG4106TD9	Diguanylate cyclase
C4E16_04105	ENOG4105DR4	Methyltransferase
C4E16_04110	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
C4E16_04115	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
C4E16_04120	ENOG4108MN8	Membrane
C4E16_04125	ENOG4105CDA	abc transporter atp-binding protein
C4E16_04130	ENOG4105DRP	amino acid AbC transporter
C4E16_04135	ENOG4105EZ7	amino acid ABC transporter
C4E16_04140	ENOG4107QXX	ABC transporter
C4E16_04150	ENOG410667J	hydrolase
C4E16_04155	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
C4E16_04160	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
C4E16_04180	ENOG4105BZU	Histidine kinase
C4E16_04190	ENOG4105BZU	Histidine kinase
C4E16_04195	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
C4E16_04200	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
C4E16_04215	ENOG4105BZU	Histidine kinase
C4E16_04235	ENOG4105CQ7	ATP-dependent helicase
C4E16_04245	ENOG4105R8A	Heat shock protein
C4E16_04250	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
C4E16_04260	ENOG4105EJC	lysr family transcriptional regulator
C4E16_04265	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4E16_04270	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
C4E16_04275	ENOG4105KPY	Small multidrug resistance protein
C4E16_04280	ENOG4108NVR	Methyl-accepting chemotaxis
C4E16_04285	ENOG4108VYJ	response regulator receiver protein
C4E16_04295	ENOG4105CBS	Chea signal transduction histidine kinase
C4E16_04300	ENOG4105CBS	Chea signal transduction histidine kinase
C4E16_04305	ENOG4105BZU	Histidine kinase
C4E16_04315	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
C4E16_04320	ENOG4108V3W	Chemotaxis protein, CheW
C4E16_04325	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_04330	ENOG4108N3W	hemolysin secretion protein
C4E16_04335	ENOG4107SDU	Methyl-accepting chemotaxis
C4E16_04340	ENOG4105C1J	atp-dependent rna helicase
C4E16_04350	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
C4E16_04355	ENOG4105CW7	secretion protein, HlyD family
C4E16_04360	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4E16_04365	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_04370	ENOG4105CTD	carboxy-peptidase
C4E16_04375	ENOG4108WC9	type VI secretion system effector, hcp1 family
C4E16_04380	ENOG4105CS6	Rhs element vgr protein
C4E16_04405	ENOG410829K	Lysine exporter protein (Lyse ygga)
C4E16_04410	ENOG4105BZG	amino acid carrier protein
C4E16_04425	ENOG4107RUE	extracellular solute-binding protein family 1
C4E16_04430	ENOG4107RUE	extracellular solute-binding protein family 1
C4E16_04435	ENOG4105D38	putrescine abc transporter
C4E16_04440	ENOG4105F38	ABC transporter, permease
C4E16_04445	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
C4E16_04465	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
C4E16_04470	ENOG4105Q9Y	Universal stress protein
C4E16_04475	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
C4E16_04490	ENOG4105C59	p-type ATPase
C4E16_04500	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
C4E16_04515	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
C4E16_04530	ENOG4105BZU	Histidine kinase
C4E16_04555	ENOG4108RC6	RTX toxin
C4E16_04560	ENOG4105EUK	rtx toxin RtxA
C4E16_04570	ENOG4107927	Cholera enterotoxin, A subunit
C4E16_04575	ENOG4105MQ5	zona occludens toxin
C4E16_04605	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
C4E16_04630	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
C4E16_04695	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
C4E16_04700	ENOG4105DAN	ATP-dependent protease
C4E16_04705	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
C4E16_04720	ENOG4105C5H	ABC transporter
C4E16_04730	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
C4E16_04735	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
C4E16_04740	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
C4E16_04745	ENOG4105C7I	Dehydrogenase
C4E16_04755	ENOG4105CD8	aminopeptidase N
C4E16_04765	ENOG4105CN1	protease
C4E16_04770	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
C4E16_04775	ENOG4108ZGC	gaf domain protein
C4E16_04780	ENOG4105BZ1	(ABC) transporter
C4E16_04785	ENOG4105H2K	paraquat-inducible protein a
C4E16_04790	ENOG4105DY2	Paraquat-inducible protein b
C4E16_04795	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
C4E16_04800	ENOG4105QNR	S1 RNA binding domain protein
C4E16_04815	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
C4E16_04825	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
C4E16_04840	ENOG4105QAX	Iron-sulfur
C4E16_04845	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
C4E16_04855	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
C4E16_04875	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
C4E16_04880	ENOG4105C5H	ABC transporter
C4E16_04885	ENOG4105BZU	Histidine kinase
C4E16_04890	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_04900	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
C4E16_04905	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
C4E16_04910	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
C4E16_04915	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
C4E16_04945	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
C4E16_04950	ENOG4106IUH	DTW domain containing protein
C4E16_04960	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_04965	ENOG4107TT5	NLP P60 protein
C4E16_04975	ENOG4105FGM	Fructosamine kinase
C4E16_04985	ENOG4107QI1	Mate efflux family protein
C4E16_05010	ENOG41067XB	TonB family
C4E16_05015	ENOG4109015	Biopolymer transport protein exbD tolR
C4E16_05045	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
C4E16_05050	ENOG4108IJ9	(ABC) transporter
C4E16_05055	ENOG4105E98	transcriptional regulator DeoR family
C4E16_05060	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
C4E16_05065	ENOG4105XEP	YhcH YjgK YiaL family protein
C4E16_05070	ENOG4105M4H	endoribonuclease L-psp
C4E16_05075	ENOG4105DDV	Transcriptional regulator (LacI family
C4E16_05080	ENOG4105CS2	ec 3.2.1.21
C4E16_05085	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
C4E16_05100	ENOG4107QZV	Type I secretion membrane fusion protein
C4E16_05110	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C4E16_05115	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C4E16_05120	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C4E16_05125	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
C4E16_05130	ENOG4105C4M	(Ubiquinol oxidase) subunit I
C4E16_05145	ENOG4105C9Q	fumarate hydratase class II
C4E16_05175	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
C4E16_05180	ENOG4105DUM	transcriptional regulator, lysR family
C4E16_05185	ENOG4108TWJ	NADH dehydrogenase subunit 5
C4E16_05195	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
C4E16_05205	ENOG4105CH6	catalase
C4E16_05225	ENOG4105C7K	acetolactate synthase
C4E16_05235	ENOG4105BZU	Histidine kinase
C4E16_05240	ENOG4106TD9	Diguanylate cyclase
C4E16_05245	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
C4E16_05250	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
C4E16_05255	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
C4E16_05280	ENOG4105BZU	Histidine kinase
C4E16_05300	ENOG4107R88	Chemotaxis protein (CheV)
C4E16_05310	ENOG4106YYS	transcriptional regulatory protein
C4E16_05315	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
C4E16_05330	ENOG4107V40	secretion protein, HlyD family
C4E16_05350	ENOG4105CVG	Homoserine O-transsuccinylase
C4E16_05355	ENOG41090FY	type IV pilus biogenesis stability protein PilW
C4E16_05365	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
C4E16_05370	ENOG4108VKG	metal-dependent hydrolase
C4E16_05380	ENOG4105F04	LysR family Transcriptional regulator
C4E16_05400	ENOG4105DFG	type I secretion outer membrane protein
C4E16_05405	ENOG4105CDV	Ompa motb domain protein
C4E16_05410	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
C4E16_05415	ENOG4105E3Q	saccharopine dehydrogenase
C4E16_05430	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
C4E16_05445	ENOG4108I0Y	(ABC) transporter
C4E16_05450	ENOG4105UQX	Mate efflux family protein
C4E16_05455	ENOG4105CGD	Nad-dependent epimerase dehydratase
C4E16_05465	ENOG4105C2C	drug resistance transporter, Bcr CflA
C4E16_05470	ENOG4105I08	Pseudouridine synthase
C4E16_05475	ENOG4105CFI	type iii restriction protein res subunit
C4E16_05495	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
C4E16_05515	ENOG4108N3W	hemolysin secretion protein
C4E16_05545	ENOG4105KXC	Collagenase
C4E16_05555	ENOG4105BZU	Histidine kinase
C4E16_05560	ENOG4105BZU	Histidine kinase
C4E16_05565	ENOG4105CJW	magnesium transporter
C4E16_05575	ENOG4105C44	Serine transporter
C4E16_05585	ENOG4105CJ1	ABC, transporter
C4E16_05590	ENOG4107QWP	ABC-2 type transporter
C4E16_05600	ENOG4105XZD	Fe-S protein
C4E16_05610	ENOG4105VNH	ABC transporter solute-binding protein
C4E16_05615	ENOG4105CXZ	ABC transporter, permease
C4E16_05620	ENOG4108VGW	abc transporter atp-binding protein
C4E16_05625	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
C4E16_05630	ENOG4108W1A	pseudouridine synthase
C4E16_05635	ENOG4105C8J	)-transporter
C4E16_05645	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
C4E16_05650	ENOG4105C28	cystathionine
C4E16_05655	ENOG4108R3E	Dna-3-methyladenine glycosylase i
C4E16_05670	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
C4E16_05685	ENOG41087YS	Phage shock protein A
C4E16_05690	ENOG4105E51	psp operon transcriptional activator
C4E16_05695	ENOG4108J59	Extracellular solute-binding protein, family 5
C4E16_05700	ENOG4108I5W	peptide transport system, permease protein
C4E16_05705	ENOG4108EU3	peptide transport system, permease
C4E16_05710	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
C4E16_05715	ENOG4108JQ2	peptide transport system atp-binding protein
C4E16_05730	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
C4E16_05755	ENOG4107QY8	reductase
C4E16_05775	ENOG4105TMB	Formate nitrite transporter
C4E16_05790	ENOG4108535	NAD dependent epimerase/dehydratase family
C4E16_05795	ENOG4105GFG	DUF218 domain
C4E16_05805	ENOG4107835	probably involved in intracellular septation (By similarity)
C4E16_05810	ENOG4105NAU	thioesterase Superfamily protein
C4E16_05815	ENOG4105K9H	YciI-like protein
C4E16_05825	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
C4E16_05830	ENOG4105DZ2	Transcriptional regulator
C4E16_05850	ENOG4105BZU	Histidine kinase
C4E16_05855	ENOG4105CCT	upf0313 protein
C4E16_05865	ENOG4105EW9	transcriptional regulator AsnC family
C4E16_05870	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
C4E16_05875	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
C4E16_05880	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
C4E16_05885	ENOG4106371	Methyltransferase
C4E16_05890	ENOG4107S90	membrAne
C4E16_05895	ENOG4106WF9	DNA-binding transcriptional regulator TorR
C4E16_05900	ENOG4108SBI	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
C4E16_05910	ENOG4105ETE	Transcriptional regulator (LacI family
C4E16_05915	ENOG4105HP8	regulator of competence-specific genes
C4E16_05935	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
C4E16_05940	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
C4E16_05945	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
C4E16_05950	ENOG4105RKX	Protein of unknown function (DUF2498)
C4E16_05955	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
C4E16_05965	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
C4E16_05970	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
C4E16_05975	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
C4E16_05990	ENOG4107QPN	acyl-Coa dehydrogenase
C4E16_05995	ENOG41067SE	Tetr family transcriptional regulator
C4E16_06005	ENOG4105MTM	Protein of unknown function (DUF1496)
C4E16_06010	ENOG4105C26	Dehydrogenase
C4E16_06015	ENOG4108R86	Transcriptional regulator
C4E16_06045	ENOG4105F1S	paraquat-inducible protein a
C4E16_06050	ENOG4105DY2	Paraquat-inducible protein b
C4E16_06075	ENOG4105DFP	Integrase
C4E16_06080	ENOG4105DFP	Integrase
C4E16_06085	ENOG4105C0D	helicase
C4E16_06105	ENOG4105DZR	Type I site-specific deoxyribonuclease
C4E16_06125	ENOG4105CVR	type I restriction-modification system
C4E16_06145	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
C4E16_06150	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
C4E16_06155	ENOG4105QEK	Transcriptional regulator
C4E16_06165	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
C4E16_06170	ENOG41069H7	transport system small permease component
C4E16_06175	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
C4E16_06185	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
C4E16_06190	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
C4E16_06195	ENOG4105CE4	GlcNAc 6-P deacetylase
C4E16_06200	ENOG4108478	ec 3.2.1.18
C4E16_06210	ENOG4108YGG	dna repair protein
C4E16_06225	ENOG4108NYK	Tape measure protein
C4E16_06350	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
C4E16_06360	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
C4E16_06365	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
C4E16_06370	ENOG4105C26	Dehydrogenase
C4E16_06380	ENOG4105DM4	PTS System
C4E16_06385	ENOG4105DM4	PTS System
C4E16_06390	ENOG4108YRF	PTS System
C4E16_06400	ENOG4106R3P	AraC family transcriptional regulator
C4E16_06405	ENOG4105DM4	PTS System
C4E16_06410	ENOG4105EIP	mannose-6-phosphate isomerase
C4E16_06415	ENOG4108RNS	Exports L-alanine (By similarity)
C4E16_06420	ENOG4105BZU	Histidine kinase
C4E16_06430	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
C4E16_06440	ENOG4105KCK	Peptidoglycan-associated lipoprotein
C4E16_06445	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
C4E16_06455	ENOG4105M8F	Biopolymer transport protein exbD tolR
C4E16_06460	ENOG4105E02	MotA TolQ exbB proton channel
C4E16_06465	ENOG4107YD3	Thioesterase
C4E16_06470	ENOG4105KJB	cyd operon protein YbgE
C4E16_06480	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
C4E16_06485	ENOG4105C4M	(Ubiquinol oxidase) subunit I
C4E16_06490	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
C4E16_06495	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
C4E16_06500	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
C4E16_06505	ENOG4105C8N	cysteinyl-tRNA synthetase
C4E16_06510	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
C4E16_06515	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
C4E16_06520	ENOG4105D58	Diguanylate phosphodiesterase
C4E16_06535	ENOG4105ZU8	porin-like protein H
C4E16_06540	ENOG4105DVT	helicase
C4E16_06545	ENOG4105EJ9	Membrane
C4E16_06550	ENOG4108URS	primosomal replication protein n''
C4E16_06555	ENOG4106428	Protein of unknown function (DUF2496)
C4E16_06560	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_06565	ENOG4105CGK	Exodeoxyribonuclease III
C4E16_06570	ENOG4106YG3	ABC transporter
C4E16_06575	ENOG4105DSP	amino acid AbC transporter
C4E16_06580	ENOG4105E89	ABC transporter
C4E16_06585	ENOG4108JEH	abc transporter atp-binding protein
C4E16_06600	ENOG4105C6N	Formate acetyltransferase
C4E16_06610	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_06615	ENOG4105F1A	Pyruvate formate-lyase
C4E16_06625	ENOG4105XWI	UPF0304 protein
C4E16_06630	ENOG4105CYN	Serine protein kinase
C4E16_06635	ENOG4106AKX	UPF0229 protein
C4E16_06640	ENOG4105ED1	spovr family
C4E16_06645	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
C4E16_06655	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
C4E16_06660	ENOG4105BZ1	(ABC) transporter
C4E16_06665	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
C4E16_06675	ENOG4105D60	lipoprotein releasing system transmembrane protein
C4E16_06680	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C4E16_06685	ENOG4105D60	lipoprotein releasing system transmembrane protein
C4E16_06695	ENOG4108JA2	transcriptioN-repair coupling factor
C4E16_06705	ENOG4106M3D	hemolysin
C4E16_06715	ENOG4105CEP	NADH dehydrogenase
C4E16_06745	ENOG4105K59	histidine triad (HIT) protein
C4E16_06750	ENOG4108NVR	Methyl-accepting chemotaxis
C4E16_06760	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
C4E16_06765	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
C4E16_06770	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
C4E16_06775	ENOG4105CNU	cell division protein FtsK
C4E16_06780	ENOG4105EW9	transcriptional regulator AsnC family
C4E16_06785	ENOG4105DCF	alanine dehydrogenase
C4E16_06795	ENOG4107R11	Transcriptional regulator
C4E16_06805	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
C4E16_06810	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
C4E16_06815	ENOG4105CFV	Tetratricopeptide repeat protein
C4E16_06820	ENOG4105Q4A	inner membrane protein yciS
C4E16_06825	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
C4E16_06830	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
C4E16_06835	ENOG4105CAT	Cytidine monophosphate kinase
C4E16_06840	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
C4E16_06845	ENOG4105EIN	peptidylprolyl cis-trans isomerase
C4E16_06850	ENOG4105K70	DNA-binding protein
C4E16_06855	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
C4E16_06860	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
C4E16_06865	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
C4E16_06870	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
C4E16_06885	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_06890	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
C4E16_06895	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
C4E16_06900	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
C4E16_06905	ENOG4105CNG	UPF0061 protein
C4E16_06920	ENOG4105BZU	Histidine kinase
C4E16_06930	ENOG4108HPI	phosphatidate Cytidylyltransferase
C4E16_06970	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
C4E16_06985	ENOG4105JQN	Transcriptional regulator
C4E16_07000	ENOG4107QY8	reductase
C4E16_07005	ENOG4105CUW	cytochrome C-TYPE protein
C4E16_07010	ENOG410662T	chitinase
C4E16_07015	ENOG4105D9N	nucleoside
C4E16_07020	ENOG4105JQN	Transcriptional regulator
C4E16_07025	ENOG4105CVE	Lytic murein transglycosylase
C4E16_07030	ENOG4105VNG	YcgL domain-containing protein
C4E16_07035	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
C4E16_07040	ENOG4107QMS	site-determining protein
C4E16_07045	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
C4E16_07070	ENOG4107S74	Lysophospholipid transporter LplT
C4E16_07075	ENOG4108N3W	hemolysin secretion protein
C4E16_07080	ENOG4108JCI	Transcriptional regulator
C4E16_07085	ENOG4105DKK	Benzoate
C4E16_07090	ENOG4105CEY	Amp-dependent synthetase and ligase
C4E16_07095	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
C4E16_07100	ENOG4108IPT	Naphthoate synthase
C4E16_07105	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
C4E16_07110	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
C4E16_07115	ENOG4105E4F	Isochorismate synthase
C4E16_07120	ENOG4105CHM	Aminotransferase
C4E16_07125	ENOG4105DK2	UPF0207 protein
C4E16_07130	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
C4E16_07150	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
C4E16_07155	ENOG4105CEY	Amp-dependent synthetase and ligase
C4E16_07160	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
C4E16_07175	ENOG41072GX	Peptidase M22 Glycoprotease
C4E16_07180	ENOG4105DVT	helicase
C4E16_07195	ENOG4105CIY	formyltetrahydrofolate deformylase
C4E16_07200	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
C4E16_07205	ENOG4105D07	Signal peptide peptidase, SppA
C4E16_07210	ENOG4105HDK	L-asparaginase
C4E16_07215	ENOG4105VUT	cytoplasmic protein
C4E16_07225	ENOG4105E0X	reductase
C4E16_07230	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
C4E16_07235	ENOG4105DSB	aldose 1-epimerase
C4E16_07255	ENOG4105DHI	Methyltransferase
C4E16_07270	ENOG4107R88	Chemotaxis protein (CheV)
C4E16_07275	ENOG4105DAG	ROK family
C4E16_07280	ENOG4105CA9	Pyruvate kinase
C4E16_07285	ENOG4108NRW	Phospholipase, patatin family
C4E16_07300	ENOG4105C8J	)-transporter
C4E16_07310	ENOG4105CI1	PTS System
C4E16_07315	ENOG4105F8V	Hydrolase, tatD family
C4E16_07320	ENOG4107QRG	dna polymerase iii
C4E16_07325	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
C4E16_07330	ENOG4105HHA	aminodeoxychorismate lyase
C4E16_07335	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
C4E16_07340	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
C4E16_07345	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
C4E16_07350	ENOG4105CHR	reductase
C4E16_07355	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
C4E16_07360	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
C4E16_07365	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
C4E16_07370	ENOG4105VGS	50s ribosomal protein l32
C4E16_07375	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
C4E16_07380	ENOG4108UHJ	MAF-like protein
C4E16_07385	ENOG4105EI2	Pseudouridine synthase
C4E16_07400	ENOG4105C03	ribonuclease
C4E16_07405	ENOG4105CHH	sulfate transporter
C4E16_07420	ENOG4108EKI	Dehydrogenase
C4E16_07425	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
C4E16_07430	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
C4E16_07435	ENOG4105DFD	Na H antiporter
C4E16_07445	ENOG4106V8H	Nucleoid-associated protein
C4E16_07455	ENOG4105E68	Sulfatase
C4E16_07470	ENOG4105DGU	Histone deacetylase
C4E16_07475	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
C4E16_07480	ENOG4105M2J	Glutaredoxin
C4E16_07485	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
C4E16_07500	ENOG410903C	(LipO)protein
C4E16_07510	ENOG4105KWW	Biogenesis protein
C4E16_07515	ENOG4107QX9	Thiol disulfide interChange protein
C4E16_07520	ENOG4105DA4	cytochrome c-type biogenesis protein
C4E16_07525	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
C4E16_07530	ENOG41067VX	Heme exporter protein
C4E16_07535	ENOG41060IM	Heme exporter protein
C4E16_07540	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
C4E16_07545	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
C4E16_07555	ENOG4108V3W	Chemotaxis protein, CheW
C4E16_07565	ENOG4107QJE	Chromosome Partitioning Protein
C4E16_07570	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
C4E16_07575	ENOG4105CBS	Chea signal transduction histidine kinase
C4E16_07580	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
C4E16_07585	ENOG4108VYJ	response regulator receiver protein
C4E16_07590	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4E16_07595	ENOG4107R21	site-determining protein
C4E16_07600	ENOG4105FZW	flagellar biosynthesis regulator FlhF
C4E16_07605	ENOG4105D7B	Flagellar biosynthesis protein flha
C4E16_07610	ENOG4108BY2	phosphohistidine phosphatase
C4E16_07615	ENOG4108JQM	Insulinase (Peptidase family M16)
C4E16_07625	ENOG4105C75	arginyL-tRNA synthetase
C4E16_07645	ENOG4105XFK	Ferrous iron transport protein A
C4E16_07650	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
C4E16_07655	ENOG4105NXV	High-affinity zinc uptake system protein
C4E16_07660	ENOG4105FDK	ABC transporter
C4E16_07665	ENOG4105FAV	ABC, transporter
C4E16_07670	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
C4E16_07675	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
C4E16_07680	ENOG4105C7S	Dehydrogenase
C4E16_07685	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
C4E16_07690	ENOG4105E33	succinate dehydrogenase
C4E16_07695	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
C4E16_07700	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
C4E16_07705	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
C4E16_07710	ENOG4105BZN	citrate synthase
C4E16_07715	ENOG4107QNR	UPF0135 protein
C4E16_07725	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
C4E16_07730	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
C4E16_07735	ENOG4105EV9	Alpha Beta Hydrolase
C4E16_07745	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
C4E16_07750	ENOG41067MG	lrgb family
C4E16_07755	ENOG4105VAW	lrga family
C4E16_07760	ENOG4105CMU	LysR family (Transcriptional regulator
C4E16_07770	ENOG41090R7	Ferric uptake
C4E16_07775	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
C4E16_07780	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
C4E16_07785	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
C4E16_07790	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
C4E16_07795	ENOG4105Q8W	reductase
C4E16_07800	ENOG4105MH2	YfcL protein
C4E16_07805	ENOG4108BPE	-transporting atpase
C4E16_07810	ENOG4105EN6	Membrane
C4E16_07815	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
C4E16_07825	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
C4E16_07835	ENOG4105D00	flagellar biosynthetic protein flhB
C4E16_07840	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
C4E16_07845	ENOG4105VS8	Flagellar biosynthetic protein fliq
C4E16_07850	ENOG4105CN7	Flagellar biosynthetic protein FliP
C4E16_07855	ENOG4105VTB	flagellar biosynthesis protein fliO
C4E16_07860	ENOG4105DD5	Flagellar motor switch protein
C4E16_07865	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
C4E16_07870	ENOG4105X6C	Flagellar basal body-associated protein FliL
C4E16_07890	ENOG4108JIR	Flagellum-specific ATP synthase
C4E16_07895	ENOG4105W2B	Flagellar assembly protein
C4E16_07900	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
C4E16_07905	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
C4E16_07910	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
C4E16_07915	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_07920	ENOG4105BZU	Histidine kinase
C4E16_07925	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_07930	ENOG4105MQ3	flagellar protein FliS
C4E16_07940	ENOG4107W9T	flagellar hook-associated
C4E16_07945	ENOG41063QE	flagellar protein FlaG
C4E16_07950	ENOG4105I03	Flagellin
C4E16_07955	ENOG4105I03	Flagellin
C4E16_07960	ENOG4105I03	Flagellin
C4E16_07965	ENOG4105EZR	dyp-type peroxidase family protein
C4E16_07970	ENOG4105QZU	Inner membrane protein YfeZ
C4E16_07985	ENOG4105KUZ	arsenate reductase
C4E16_07990	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
C4E16_08005	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
C4E16_08010	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
C4E16_08020	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4E16_08025	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_08040	ENOG4105ERG	peptidase m48, ste24p
C4E16_08045	ENOG4105K89	arsenate reductase
C4E16_08050	ENOG4105CS1	NAD(P)H quinone oxidoreductase
C4E16_08065	ENOG4105C2W	permease
C4E16_08070	ENOG4108Z66	YbaK ebsC protein
C4E16_08075	ENOG4105CGH	5'-nucleotidase
C4E16_08080	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
C4E16_08085	ENOG41063JG	Transcriptional regulator
C4E16_08090	ENOG4108YY7	Invasion gene expression up-regulator SirB
C4E16_08095	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
C4E16_08100	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
C4E16_08105	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
C4E16_08110	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
C4E16_08115	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
C4E16_08120	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
C4E16_08125	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
C4E16_08130	ENOG4105C3G	gtp-binding protein
C4E16_08160	ENOG4105I03	Flagellin
C4E16_08165	ENOG4105I03	Flagellin
C4E16_08180	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
C4E16_08185	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
C4E16_08190	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
C4E16_08195	ENOG4105CGA	flagellar basal-body rod protein FlgG
C4E16_08200	ENOG4108KPB	Flagellar basal-body rod protein FlgF
C4E16_08205	ENOG4105BZE	flagellar hook protein, FlgE
C4E16_08210	ENOG4105W00	Flagellar hook capping protein
C4E16_08215	ENOG4108ZC9	flagellar basal-body rod protein flgc
C4E16_08220	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
C4E16_08225	ENOG4105BZU	Histidine kinase
C4E16_08230	ENOG4107R88	Chemotaxis protein (CheV)
C4E16_08265	ENOG4105C0W	non-ribosomal peptide synthetase
C4E16_08270	ENOG4105Q26	Siderophore-interacting protein
C4E16_08275	ENOG4107RBR	Receptor
C4E16_08285	ENOG4105UYK	outer membrane protein a
C4E16_08290	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
C4E16_08295	ENOG4105C59	p-type ATPase
C4E16_08305	ENOG4105E2D	ec 3.2.1.52
C4E16_08310	ENOG4105MBR	gumn family
C4E16_08325	ENOG4108DG9	Smr protein MutS2
C4E16_08330	ENOG4105FE9	pseudouridine synthase
C4E16_08335	ENOG4105BZU	Histidine kinase
C4E16_08340	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
C4E16_08345	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
C4E16_08350	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
C4E16_08355	ENOG4105E7A	Glutamine amidotransferase
C4E16_08360	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
C4E16_08365	ENOG4107QPN	acyl-Coa dehydrogenase
C4E16_08375	ENOG4108JDX	DNA polymerase iii, epsilon subunit
C4E16_08380	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C4E16_08385	ENOG4105D1A	Methyltransferase
C4E16_08390	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
C4E16_08395	ENOG4105E9H	Lytic Murein transglycosylase
C4E16_08405	ENOG4108YZA	Nitrogen regulatory protein pii
C4E16_08410	ENOG4105PY6	Phenolic acid decarboxylase
C4E16_08415	ENOG4105N7H	Cytochrome
C4E16_08420	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
C4E16_08425	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
C4E16_08430	ENOG4105C0B	DNA polymerase III (alpha subunit)
C4E16_08435	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C4E16_08440	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C4E16_08445	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C4E16_08450	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
C4E16_08455	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C4E16_08460	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
C4E16_08470	ENOG4105DZP	Membrane-associated zinc metalloprotease
C4E16_08475	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
C4E16_08480	ENOG4105KNE	Phosphatidate cytidylyltransferase
C4E16_08485	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
C4E16_08490	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
C4E16_08495	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
C4E16_08500	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
C4E16_08505	ENOG4105CE9	30S ribosomal protein S2
C4E16_08510	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
C4E16_08515	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
C4E16_08525	ENOG4108T8E	UPF0325 protein
C4E16_08530	ENOG4108ZAI	phosphatidylglycerophosphatase a
C4E16_08535	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
C4E16_08540	ENOG4107YIM	Involved in the transcription termination process (By similarity)
C4E16_08545	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
C4E16_08560	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
C4E16_08565	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
C4E16_08570	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
C4E16_08575	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
C4E16_08580	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
C4E16_08590	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
C4E16_08595	ENOG4105C7N	Xanthine uracil vitamin C permease
C4E16_08600	ENOG4105CIN	aminoacyl-histidine dipeptidase
C4E16_08605	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
C4E16_08610	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
C4E16_08620	ENOG4105C8J	)-transporter
C4E16_08635	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
C4E16_08645	ENOG4105CJ2	(LipO)protein
C4E16_08650	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
C4E16_08655	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C4E16_08660	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C4E16_08665	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C4E16_08670	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C4E16_08675	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C4E16_08680	ENOG4105M85	Bola protein
C4E16_08685	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
C4E16_08695	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
C4E16_08705	ENOG4105EYM	Major Facilitator superfamily
C4E16_08715	ENOG4105K6V	RNA polymerase
C4E16_08725	ENOG4105DRB	nucleoside-specific channel-forming protein
C4E16_08730	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
C4E16_08735	ENOG4107S0N	DJ-1 family
C4E16_08740	ENOG4105C9B	Cysteine desulfurase
C4E16_08745	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
C4E16_08750	ENOG4105CUZ	uba thif-type nad fad binding protein
C4E16_08755	ENOG4105CA3	membrane-bound lytic murein transglycosylase
C4E16_08765	ENOG4107QZM	n-acetylglutamate synthase
C4E16_08775	ENOG4107QYX	exodeoxyribonuclease v alpha
C4E16_08780	ENOG4107QKA	exodeoxyribonuclease V beta
C4E16_08785	ENOG4105DSY	exodeoxyribonuclease V, gamma
C4E16_08800	ENOG4105X2V	dna damage-inducible protein
C4E16_08805	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
C4E16_08815	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
C4E16_08820	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
C4E16_08835	ENOG4108Y51	tRNA-binding protein
C4E16_08840	ENOG41060NJ	transcriptional regulator
C4E16_08845	ENOG4105CNT	hydrolase family 2
C4E16_08855	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C4E16_08860	ENOG4108IQE	Amp-dependent synthetase and ligase
C4E16_08865	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
C4E16_08870	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
C4E16_08885	ENOG4105EAC	phosphoserine phosphatase
C4E16_08895	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
C4E16_08900	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
C4E16_08905	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
C4E16_08910	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
C4E16_08920	ENOG4105D9N	nucleoside
C4E16_08925	ENOG4105EYA	deoxyribonuclease
C4E16_08935	ENOG4105BZG	amino acid carrier protein
C4E16_08950	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
C4E16_08955	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
C4E16_08960	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
C4E16_08965	ENOG4105D98	threonine synthase
C4E16_08970	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
C4E16_08990	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
C4E16_09000	ENOG41065U4	response regulator
C4E16_09005	ENOG4105BZU	Histidine kinase
C4E16_09015	ENOG4105N5T	Radical SAM Protein
C4E16_09030	ENOG4105CBC	glutamate synthase
C4E16_09035	ENOG4105BZ8	glutamate synthase
C4E16_09045	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
C4E16_09055	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
C4E16_09060	ENOG4105EN6	Membrane
C4E16_09065	ENOG4105VP0	transcriptional regulator, lysR family
C4E16_09070	ENOG4105EJ9	Membrane
C4E16_09075	ENOG4107RRE	RNA-directed DNA polymerase
C4E16_09100	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
C4E16_09105	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
C4E16_09115	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
C4E16_09120	ENOG4105M6F	mutator MutT protein
C4E16_09125	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
C4E16_09135	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C4E16_09140	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
C4E16_09145	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
C4E16_09150	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
C4E16_09155	ENOG4105DFU	Cell wall formation (By similarity)
C4E16_09160	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
C4E16_09170	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
C4E16_09175	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
C4E16_09180	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
C4E16_09185	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
C4E16_09190	ENOG4105CJN	penicillin-binding protein
C4E16_09195	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
C4E16_09200	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
C4E16_09210	ENOG4107QN2	dihydrolipoyl dehydrogenase
C4E16_09215	ENOG4107QSN	dihydrolipoamide acetyltransferase
C4E16_09220	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
C4E16_09225	ENOG41073TP	transcriptional regulator
C4E16_09235	ENOG4105CGH	5'-nucleotidase
C4E16_09240	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
C4E16_09245	ENOG4105T95	Thiol disulfide interChange protein
C4E16_09250	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C4E16_09255	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
C4E16_09265	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
C4E16_09275	ENOG4107QHF	type ii secretion system protein e
C4E16_09280	ENOG4105D7Q	type ii secretion system
C4E16_09285	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
C4E16_09290	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
C4E16_09295	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
C4E16_09300	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
C4E16_09305	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4E16_09310	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4E16_09315	ENOG4105IPS	esterase
C4E16_09320	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
C4E16_09325	ENOG4108SX3	cytoplasmic protein
C4E16_09330	ENOG41087AY	ADP-Ribose pyrophosphatase
C4E16_09335	ENOG4105DFG	type I secretion outer membrane protein
C4E16_09345	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
C4E16_09350	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_09355	ENOG4105I7R	Adenylate cyclase
C4E16_09360	ENOG4107IX6	phosphate transport regulator
C4E16_09365	ENOG4105CJ3	phosphate transporter
C4E16_09370	ENOG4106MWK	domain protein
C4E16_09385	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
C4E16_09390	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
C4E16_09395	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
C4E16_09400	ENOG4105DXN	mazG family
C4E16_09405	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
C4E16_09410	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
C4E16_09415	ENOG4105BZU	Histidine kinase
C4E16_09420	ENOG4108K0B	C-di-gmp phosphodiesterase
C4E16_09435	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
C4E16_09440	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
C4E16_09445	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
C4E16_09450	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
C4E16_09455	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
C4E16_09460	ENOG4105C3F	Signal peptidase i
C4E16_09465	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
C4E16_09470	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
C4E16_09475	ENOG4105VQK	sigma E regulatory protein, MucB RseB
C4E16_09485	ENOG4105EMN	RNA polymerase sigma factor
C4E16_09495	ENOG4108IYU	L-aspartate oxidase
C4E16_09505	ENOG4105Y75	tpr repeat protein
C4E16_09510	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
C4E16_09520	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
C4E16_09525	ENOG4105D0A	hydroxylase
C4E16_09535	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
C4E16_09545	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
C4E16_09550	ENOG4105E66	phosphoriboisomerase A
C4E16_09555	ENOG4108JQ1	Dehydrogenase
C4E16_09560	ENOG4108ZP8	Acetolactate synthase small subunit
C4E16_09565	ENOG4105C7K	acetolactate synthase
C4E16_09570	ENOG4108IQE	Amp-dependent synthetase and ligase
C4E16_09575	ENOG41064T2	transcriptional regulator, lysR family
C4E16_09595	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C4E16_09600	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
C4E16_09605	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C4E16_09610	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C4E16_09655	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C4E16_09670	ENOG4108K5H	permease YjgP YjgQ family protein
C4E16_09675	ENOG4108M8S	permease YjgP YjgQ family protein
C4E16_09680	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
C4E16_09685	ENOG4105MYG	DNA polymerase iii, chi subunit
C4E16_09690	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
C4E16_09695	ENOG4105C5I	Dehydrogenase
C4E16_09700	ENOG4105D3G	Pseudouridine synthase
C4E16_09705	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
C4E16_09715	ENOG4108IAB	Phoh family
C4E16_09720	ENOG4105DBV	ornithine carbamoyltransferase
C4E16_09725	ENOG4105CXT	aspartate transcarbamylase
C4E16_09730	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
C4E16_09735	ENOG4105KME	endoribonuclease L-psp
C4E16_09740	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
C4E16_09745	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
C4E16_09750	ENOG4105VFK	BolA family
C4E16_09760	ENOG4105E3I	toluene tolerance
C4E16_09765	ENOG4107PE3	Mammalian cell entry related domain protein
C4E16_09770	ENOG4105CY3	ABC transporter, permease
C4E16_09775	ENOG4105DHJ	ABC, transporter
C4E16_09790	ENOG4105C2X	Arabinose 5-phosphate isomerase
C4E16_09795	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
C4E16_09805	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
C4E16_09810	ENOG4108IUZ	ABC transporter
C4E16_09815	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4E16_09820	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
C4E16_09825	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
C4E16_09830	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
C4E16_09835	ENOG41080Z8	PHOSPHOCARRIER protein
C4E16_09840	ENOG4105CJW	magnesium transporter
C4E16_09845	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
C4E16_09850	ENOG4105N42	UPF0307 protein
C4E16_09855	ENOG4107T0D	ABC, transporter
C4E16_09860	ENOG4106SMU	thiamine transporter membrane protein
C4E16_09865	ENOG4105DP9	ABC transporter
C4E16_09870	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
C4E16_09875	ENOG4105DFU	Cell wall formation (By similarity)
C4E16_09885	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4E16_09890	ENOG4105F0N	pyrophosphate phospho-hydrolase
C4E16_09895	ENOG41066HZ	AIG2-like family
C4E16_09905	ENOG4105CFU	surface antigen
C4E16_09910	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
C4E16_09915	ENOG4108UUE	Transcriptional regulator
C4E16_09930	ENOG4105C19	ABC transporter
C4E16_09950	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
C4E16_09955	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
C4E16_09960	ENOG4105C11	sulfate adenylyltransferase), subunit 2
C4E16_09965	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
C4E16_09970	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
C4E16_09980	ENOG4105C1J	atp-dependent rna helicase
C4E16_09985	ENOG4107YB6	acetyltransferase, (GNAT) family
C4E16_09990	ENOG4108SXK	Transporter Drug Metabolite Exporter family
C4E16_09995	ENOG4108UBT	opacity-associated protein
C4E16_10000	ENOG4108V1T	peptidylprolyl cis-trans isomerase
C4E16_10010	ENOG4108ZT0	50S ribosomal protein l17
C4E16_10015	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4E16_10020	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
C4E16_10025	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
C4E16_10030	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4E16_10040	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
C4E16_10045	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
C4E16_10050	ENOG4105VPB	50S ribosomal protein L30
C4E16_10055	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
C4E16_10060	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
C4E16_10065	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
C4E16_10070	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
C4E16_10075	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
C4E16_10080	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4E16_10085	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
C4E16_10090	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
C4E16_10095	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
C4E16_10100	ENOG41083MP	50s ribosomal protein l29
C4E16_10105	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
C4E16_10110	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
C4E16_10115	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
C4E16_10120	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
C4E16_10125	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4E16_10130	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
C4E16_10135	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
C4E16_10140	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
C4E16_10145	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
C4E16_10150	ENOG4105C2N	RNA methyltransferase TrmH family group 3
C4E16_10155	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
C4E16_10160	ENOG4105E68	Sulfatase
C4E16_10165	ENOG4108UV7	flagellar protein motX
C4E16_10175	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
C4E16_10180	ENOG4105D44	asparaginase
C4E16_10185	ENOG4108YZY	peptidylprolyl cis-trans isomerase
C4E16_10200	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
C4E16_10205	ENOG4105C5H	ABC transporter
C4E16_10215	ENOG4105DNZ	Alpha Beta Hydrolase
C4E16_10225	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
C4E16_10230	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
C4E16_10240	ENOG4105C26	Dehydrogenase
C4E16_10250	ENOG4105C8Y	Acetylornithine aminotransferase
C4E16_10255	ENOG4105DDQ	anthranilate synthase
C4E16_10260	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
C4E16_10275	ENOG4105C31	Tryptophanyl-tRNA synthetase
C4E16_10280	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C4E16_10285	ENOG4105DJV	ribulose-phosphate 3-epimerase
C4E16_10290	ENOG4105DFE	Dna adenine methylase
C4E16_10300	ENOG4105D49	3-dehydroquinate synthase
C4E16_10305	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
C4E16_10310	ENOG4105E4G	Type IV pilus
C4E16_10335	ENOG4108JQC	penicillin-binding protein 1A
C4E16_10345	ENOG4105EHV	domain protein
C4E16_10350	ENOG4107QN2	dihydrolipoyl dehydrogenase
C4E16_10360	ENOG4105CH7	arginosuccinase
C4E16_10370	ENOG4105CDH	Citrulline--aspartate ligase
C4E16_10375	ENOG4105CAS	nag kinase
C4E16_10380	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
C4E16_10385	ENOG4105CWC	Acetylornithine deacetylase
C4E16_10390	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
C4E16_10400	ENOG4105D7W	serine acetyltransferase
C4E16_10405	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
C4E16_10410	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
C4E16_10415	ENOG4107YZP	Rhodanese domain protein
C4E16_10420	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
C4E16_10430	ENOG4105E33	succinate dehydrogenase
C4E16_10435	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
C4E16_10440	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
C4E16_10445	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
C4E16_10450	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
C4E16_10460	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
C4E16_10465	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
C4E16_10495	ENOG4105CP7	Triose-phosphate isomerase
C4E16_10505	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
C4E16_10510	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
C4E16_10515	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
C4E16_10520	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
C4E16_10525	ENOG41063M6	Cell Division Protein
C4E16_10530	ENOG4105ETE	Transcriptional regulator (LacI family
C4E16_10535	ENOG4105C25	Primosomal protein n'
C4E16_10540	ENOG4105VFB	Binds the 23S rRNA (By similarity)
C4E16_10545	ENOG4105C6K	Malic enzyme
C4E16_10550	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
C4E16_10555	ENOG4105C28	cystathionine
C4E16_10560	ENOG4105CFH	Aspartokinase
C4E16_10565	ENOG4105SYT	Methylenetetrahydrofolate reductase
C4E16_10570	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
C4E16_10575	ENOG4105CBT	Fructose-1,6-bisphosphatase
C4E16_10580	ENOG4105CTQ	phosphohexokinase
C4E16_10585	ENOG41076HS	cation diffusion facilitator family transporter
C4E16_10595	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
C4E16_10600	ENOG4105E0F	Histidine kinase
C4E16_10610	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
C4E16_10615	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
C4E16_10620	ENOG4105BZU	Histidine kinase
C4E16_10625	ENOG4108IJ0	Aspartate ammonia-lyase
C4E16_10630	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
C4E16_10640	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
C4E16_10650	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
C4E16_10660	ENOG4107QN1	sodium solute
C4E16_10665	ENOG4105EX9	Membrane
C4E16_10670	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
C4E16_10675	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
C4E16_10680	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
C4E16_10685	ENOG4105CB5	ATP-dependent DNA helicase recG
C4E16_10690	ENOG4105C2W	permease
C4E16_10695	ENOG4105E0F	Histidine kinase
C4E16_10700	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
C4E16_10705	ENOG4108RRZ	Transcription elongation factor GreB
C4E16_10710	ENOG4105BZM	domain protein
C4E16_10720	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
C4E16_10725	ENOG4105MJ2	Competence protein
C4E16_10730	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
C4E16_10735	ENOG4107RK2	ADP-ribose diphosphatase NudE
C4E16_10740	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
C4E16_10745	ENOG4105PIC	general secretion pathway protein N
C4E16_10750	ENOG4105U1E	general secretion pathway protein M
C4E16_10755	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
C4E16_10760	ENOG4108RTD	type II secretion system protein K
C4E16_10765	ENOG4108WWZ	General secretion pathway protein J
C4E16_10770	ENOG4105X5Z	General secretion pathway protein I
C4E16_10775	ENOG4105VWV	general secretion pathway protein h
C4E16_10780	ENOG4108VAU	general secretion pathway protein G
C4E16_10785	ENOG4105D7Q	type ii secretion system
C4E16_10790	ENOG4107QHF	type ii secretion system protein e
C4E16_10800	ENOG4108XKW	General secretion pathway protein C
C4E16_10805	ENOG4105VEJ	Heat shock protein
C4E16_10810	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
C4E16_10815	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
C4E16_10825	ENOG4105SUU	thioesterase domain
C4E16_10830	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
C4E16_10840	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
C4E16_10855	ENOG4105C5F	glutamine synthetase
C4E16_10865	ENOG4105CUX	Signal transduction histidine kinase
C4E16_10870	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_10875	ENOG4105BZU	Histidine kinase
C4E16_10880	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
C4E16_10915	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
C4E16_10920	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
C4E16_10925	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
C4E16_10930	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
C4E16_10950	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
C4E16_10955	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4E16_10960	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
C4E16_10965	ENOG4105CAK	Cell division ATP-binding protein ftsE
C4E16_10970	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
C4E16_10975	ENOG4106H78	methyltransferase
C4E16_11015	ENOG4108RMU	ferritin dps family protein
C4E16_11020	ENOG4105D58	Diguanylate phosphodiesterase
C4E16_11025	ENOG410829K	Lysine exporter protein (Lyse ygga)
C4E16_11030	ENOG4108EUD	Lysophospholipase
C4E16_11035	ENOG4105DQF	Hydrolase
C4E16_11055	ENOG4105BZU	Histidine kinase
C4E16_11060	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
C4E16_11065	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C4E16_11070	ENOG4105CT0	Protein of unknown function, DUF484
C4E16_11075	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
C4E16_11080	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
C4E16_11090	ENOG4105XQ6	frataxin-like protein
C4E16_11095	ENOG4107T0K	Adenylate cyclase
C4E16_11105	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
C4E16_11110	ENOG41076E6	Uroporphyrinogen-III Synthase
C4E16_11115	ENOG4105ECF	c-methyltransferase
C4E16_11120	ENOG410601J	HemY protein
C4E16_11125	ENOG4105D4P	Coproporphyrinogen iii oxidase
C4E16_11130	ENOG4105XCT	Protein of unknown function (DUF2489)
C4E16_11135	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
C4E16_11145	ENOG4106RE7	Cytochrome
C4E16_11150	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
C4E16_11155	ENOG4105C2M	dna polymerase I
C4E16_11165	ENOG4105D52	delta-aminolevulinic acid dehydratase
C4E16_11170	ENOG4105F8V	Hydrolase, tatD family
C4E16_11180	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
C4E16_11190	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_11195	ENOG4105X6C	Flagellar basal body-associated protein FliL
C4E16_11205	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
C4E16_11210	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
C4E16_11215	ENOG4105E55	glycerol-3-phosphate acyltransferase
C4E16_11225	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
C4E16_11235	ENOG4107R73	Mate efflux family protein
C4E16_11240	ENOG4105CA0	peroxidase
C4E16_11245	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
C4E16_11250	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
C4E16_11255	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
C4E16_11260	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
C4E16_11265	ENOG4105JC1	sterol-binding domain protein
C4E16_11270	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
C4E16_11275	ENOG4105CGY	Dna recombination protein
C4E16_11285	ENOG4105CBX	hi0933 family
C4E16_11290	ENOG4108V6B	universal stress protein B
C4E16_11295	ENOG41090A1	ferritin
C4E16_11305	ENOG4108M6U	Universal stress protein A
C4E16_11310	ENOG4105EMK	carboxylate amino acid amine transporter
C4E16_11320	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
C4E16_11325	ENOG4105BZU	Histidine kinase
C4E16_11330	ENOG4108VVK	transcriptional Regulator, AsnC
C4E16_11340	ENOG4105CNH	Multidrug resistance protein MdtL
C4E16_11350	ENOG4105DC7	peptidase M24
C4E16_11350	ENOG4105DC7	peptidase M24
C4E16_11355	ENOG4105D41	biosynthesis protein thiH
C4E16_11360	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
C4E16_11365	ENOG4105WHD	thiamine biosynthesis protein ThiS
C4E16_11370	ENOG4105D06	uba thif-type nad fad binding protein
C4E16_11380	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
C4E16_11385	ENOG4105WMR	Protein CrcB homolog
C4E16_11425	ENOG4108Z0R	Transferase
C4E16_11435	ENOG4105E2X	shikimate dehydrogenase
C4E16_11440	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
C4E16_11445	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C4E16_11450	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
C4E16_11455	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
C4E16_11460	ENOG4108WI1	Dna topoisomerase
C4E16_11465	ENOG4108RPN	Protein smg homolog
C4E16_11470	ENOG4105C79	DNA protecting protein DprA
C4E16_11475	ENOG4108WZM	domain protein
C4E16_11480	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
C4E16_11485	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
C4E16_11490	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
C4E16_11495	ENOG4105C1A	potassium transporter peripheral membrane
C4E16_11500	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
C4E16_11510	ENOG4108UT2	hemolysin iii
C4E16_11515	ENOG4108N23	SpoOM-related protein
C4E16_11525	ENOG4105PC1	Conserved Protein
C4E16_11540	ENOG4105E27	serine threonine protein kinase
C4E16_11545	ENOG4108Z33	Thiol disulfide Interchange Protein
C4E16_11550	ENOG4106HNH	Acyl-transferase
C4E16_11555	ENOG4105C0P	Mg chelatase subunit ChlI
C4E16_11570	ENOG4105CM2	brancheD-chain amino acid aminotransferase
C4E16_11575	ENOG4105C01	Dihydroxy-acid dehydratase
C4E16_11580	ENOG4105C7B	Threonine dehydratase
C4E16_11585	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
C4E16_11595	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
C4E16_11615	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
C4E16_11620	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
C4E16_11630	ENOG4105JKW	Valine--pyruvate aminotransferase
C4E16_11635	ENOG4108ZNX	Heat shock protein
C4E16_11650	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4E16_11655	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
C4E16_11660	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
C4E16_11665	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
C4E16_11670	ENOG4105EAB	amino acid AbC transporter
C4E16_11675	ENOG4105E5Q	amino acid AbC transporter
C4E16_11690	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
C4E16_11695	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
C4E16_11700	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
C4E16_11705	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
C4E16_11710	ENOG4105QTB	Flavodoxin
C4E16_11720	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
C4E16_11725	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
C4E16_11730	ENOG4107QJE	Chromosome Partitioning Protein
C4E16_11735	ENOG4105FA0	parb-like partition protein
C4E16_11740	ENOG410684E	atp synthase
C4E16_11745	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
C4E16_11750	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C4E16_11755	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C4E16_11760	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C4E16_11765	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
C4E16_11770	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
C4E16_11775	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
C4E16_11780	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
C4E16_11785	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
C4E16_11790	ENOG4105CZQ	inner membrane transport protein YdhC
C4E16_11795	ENOG4105F52	Transcriptional regulator
C4E16_11800	ENOG4105CHU	acetyl-coa acetyltransferase
C4E16_11805	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
C4E16_11810	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
C4E16_11815	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
C4E16_11820	ENOG4108RR8	protoporphyrinogen oxidase
C4E16_11865	ENOG4105EMY	transcriptional regulator
C4E16_11870	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
C4E16_11875	ENOG4105W0Z	cytoplasmic protein
C4E16_11880	ENOG4105BZS	acriflavin resistance protein
C4E16_11885	ENOG410624X	efflux transporter, rnd family, mfp subunit
C4E16_11890	ENOG4105Y7M	Transcriptional regulator, TetR family
C4E16_11895	ENOG4105C4R	Atp-dependent dna helicase
C4E16_11900	ENOG4105MPD	Cytochrome
C4E16_11935	ENOG4105DEF	Extracellular solute-binding protein, family 5
C4E16_11940	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
C4E16_11945	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
C4E16_11955	ENOG4108UK2	deaminase
C4E16_11985	ENOG4108ZXE	
C4E16_12020	ENOG4105DC8	reductase
C4E16_12025	ENOG4105D6S	protein involved in catabolism of external DNA
C4E16_12030	ENOG4105DGW	oligopeptidase A
C4E16_12035	ENOG4105C4R	Atp-dependent dna helicase
C4E16_12055	ENOG4108DMH	HTH_ARAC
C4E16_12065	ENOG4105FR1	rard protein
C4E16_12070	ENOG4105C9U	ATP-dependent DNA helicase RecQ
C4E16_12085	ENOG4105BZ1	(ABC) transporter
C4E16_12090	ENOG4105E0K	tonB-dependent siderophore receptor
C4E16_12095	ENOG4105E0A	ABC, transporter
C4E16_12100	ENOG4105J76	Periplasmic binding protein
C4E16_12105	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
C4E16_12110	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
C4E16_12120	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4E16_12125	ENOG4105C5Y	PTS System
C4E16_12135	ENOG4105DSJ	YicC domain protein
C4E16_12140	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
C4E16_12145	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
C4E16_12150	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
C4E16_12155	ENOG4105D1S	lipid A biosynthesis
C4E16_12160	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
C4E16_12170	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
C4E16_12175	ENOG4108NVR	Methyl-accepting chemotaxis
C4E16_12185	ENOG4105KDC	50s ribosomal protein l28
C4E16_12190	ENOG4105W0E	50S ribosomal protein L33
C4E16_12200	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
C4E16_12205	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
C4E16_12210	ENOG4105M5K	heptosyltransferase
C4E16_12215	ENOG4106WTF	Glycosyl transferase, family 2
C4E16_12220	ENOG4105DKP	glycosyl transferase, family 9
C4E16_12225	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
C4E16_12255	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
C4E16_12260	ENOG4108ST3	glycosyltransferase
C4E16_12270	ENOG4105XA0	heptosyltransferase ii
C4E16_12285	ENOG4107T94	Endo-14-beta-xylanase
C4E16_12290	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
C4E16_12295	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
C4E16_12300	ENOG4107QKV	phosphomannomutase
C4E16_12305	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
C4E16_12310	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
C4E16_12325	ENOG4105EY8	ABC transporter
C4E16_12335	ENOG4105CEY	Amp-dependent synthetase and ligase
C4E16_12340	ENOG4108EKI	Dehydrogenase
C4E16_12350	ENOG4108UT6	Transferase hexapeptide repeat containing protein
C4E16_12390	ENOG4105D3Q	Sugar transferase
C4E16_12395	ENOG4105CY0	Metallo-Beta-Lactamase
C4E16_12400	ENOG4105CUY	Mechanosensitive ion channel
C4E16_12405	ENOG4108RG0	uracil-dna glycosylase
C4E16_12410	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
C4E16_12415	ENOG4105R2J	Conserved Protein
C4E16_12420	ENOG4105EIP	mannose-6-phosphate isomerase
C4E16_12425	ENOG4105DKQ	ROK family
C4E16_12435	ENOG4105K70	DNA-binding protein
C4E16_12445	ENOG4105C12	Phosphoribosylglycinamide synthetase
C4E16_12450	ENOG4105DC1	bifunctional purine biosynthesis protein purh
C4E16_12460	ENOG4105W1Y	Transcriptional regulator
C4E16_12465	ENOG4108M3R	transcriptional activator CadC
C4E16_12470	ENOG4105D5Q	Arginine ornithine antiporter
C4E16_12475	ENOG4105CXN	decarboxylase
C4E16_12480	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_12495	ENOG4108UHU	Aldolase
C4E16_12500	ENOG4105C6Z	Gluconate
C4E16_12505	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
C4E16_12510	ENOG4105C01	Dihydroxy-acid dehydratase
C4E16_12515	ENOG4105DIQ	Transcriptional regulator
C4E16_12520	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
C4E16_12525	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
C4E16_12530	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
C4E16_12535	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
C4E16_12540	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
C4E16_12545	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
C4E16_12550	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
C4E16_12570	ENOG4105D8G	Major Facilitator superfamily
C4E16_12575	ENOG4105BZU	Histidine kinase
C4E16_12580	ENOG4105C9X	ppx gppa phosphatase
C4E16_12585	ENOG4105C1J	atp-dependent rna helicase
C4E16_12590	ENOG4105K63	Thioredoxin
C4E16_12595	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
C4E16_12605	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
C4E16_12615	ENOG4107QK7	reductase
C4E16_12650	ENOG4105JIM	Phosphatidylserine synthase
C4E16_12660	ENOG4105D4A	Cell wall formation (By similarity)
C4E16_12665	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
C4E16_12670	ENOG4105CS9	pantothenic acid kinase
C4E16_12695	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C4E16_12700	ENOG4105PM1	preprotein translocase subunit SecE
C4E16_12705	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
C4E16_12710	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
C4E16_12715	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
C4E16_12720	ENOG4108VZM	50s ribosomal protein L10
C4E16_12725	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
C4E16_12730	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4E16_12735	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4E16_12740	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
C4E16_12745	ENOG4105E09	nadh pyrophosphatase
C4E16_12750	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
C4E16_12755	ENOG41062JF	Transcriptional regulator
C4E16_12765	ENOG41063SB	peptidase
C4E16_12770	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
C4E16_12780	ENOG4107QWE	)-transporter
C4E16_12785	ENOG4105DJ4	phosphatidylserine decarboxylase
C4E16_12790	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
C4E16_12795	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
C4E16_12840	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
C4E16_12845	ENOG4105K8N	protein family UPF0079, ATPase
C4E16_12850	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
C4E16_12855	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
C4E16_12860	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
C4E16_12865	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
C4E16_12870	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
C4E16_12875	ENOG4107QJR	hflk protein
C4E16_12880	ENOG4105EPW	hflc protein
C4E16_12890	ENOG41069P5	Protein slyX homolog
C4E16_12900	ENOG4108V1T	peptidylprolyl cis-trans isomerase
C4E16_12905	ENOG4105WWK	YheO domain protein
C4E16_12910	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
C4E16_12915	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
C4E16_12925	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
C4E16_12930	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
C4E16_12935	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
C4E16_12940	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C4E16_12945	ENOG4105W53	bacterioferritin-associated ferredoxin
C4E16_12950	ENOG4108UQY	Iron-storage protein
C4E16_12955	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
C4E16_12960	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
C4E16_12965	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
C4E16_12970	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
C4E16_12980	ENOG4105CDU	Replicative dna helicase
C4E16_12985	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C4E16_12990	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
C4E16_12995	ENOG4107QP8	phosphohexose isomerase
C4E16_13010	ENOG4105MYN	Zinc uptake regulation protein
C4E16_13015	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
C4E16_13020	ENOG4105P4Z	Phage shock protein G
C4E16_13040	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
C4E16_13045	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
C4E16_13050	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
C4E16_13090	ENOG4105EEQ	Na H antiporter
C4E16_13095	ENOG4105C3R	Methionine synthase
C4E16_13100	ENOG4105CFH	Aspartokinase
C4E16_13105	ENOG4105C5R	Aminotransferase
C4E16_13115	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
C4E16_13120	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
C4E16_13125	ENOG41086KC	Transcriptional regulator
C4E16_13130	ENOG4108UUM	single-stranded DNA-binding protein
C4E16_13135	ENOG41062P1	Diguanylate cyclase phosphodiesterase
C4E16_13155	ENOG4105E4G	Type IV pilus
C4E16_13170	ENOG4107QHF	type ii secretion system protein e
C4E16_13175	ENOG4105D7Q	type ii secretion system
C4E16_13185	ENOG4105X0D	Fimbrial protein
C4E16_13220	ENOG4105DFF	Rod shape-determining protein mreb
C4E16_13225	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
C4E16_13230	ENOG4105VQ7	Rod shape-determining protein MreD
C4E16_13235	ENOG4108Z03	MAF-like protein
C4E16_13240	ENOG4105C03	ribonuclease
C4E16_13245	ENOG4105QD6	exported protein
C4E16_13255	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
C4E16_13260	ENOG4105CEU	Arginine dihydrolase
C4E16_13280	ENOG41081QV	Universal stress protein
C4E16_13300	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
C4E16_13305	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
C4E16_13310	ENOG4105D5Q	Arginine ornithine antiporter
C4E16_13315	ENOG4105D5Q	Arginine ornithine antiporter
C4E16_13320	ENOG4105EAH	synthase
C4E16_13325	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
C4E16_13330	ENOG4105K46	50S ribosomal protein l27
C4E16_13335	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4E16_13340	ENOG4105DWK	Membrane
C4E16_13345	ENOG4107XM3	UPF0442 protein
C4E16_13355	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
C4E16_13360	ENOG4105NWN	ApaG protein
C4E16_13365	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
C4E16_13370	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
C4E16_13375	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
C4E16_13380	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
C4E16_13385	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
C4E16_13440	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
C4E16_13445	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
C4E16_13450	ENOG4105CEN	a g-specific adenine glycosylase
C4E16_13455	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
C4E16_13460	ENOG4105CSV	Glutaminase
C4E16_13465	ENOG4105CSA	Coproporphyrinogen iii oxidase
C4E16_13470	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
C4E16_13480	ENOG4105VZ9	UPF0235 protein
C4E16_13485	ENOG4108VIA	integral membrane protein
C4E16_13490	ENOG4105II7	pyrroline-5-carboxylate reductase
C4E16_13495	ENOG4105DFA	alanine racemase domain protein
C4E16_13500	ENOG4105CZX	twitching motility protein
C4E16_13505	ENOG4105CZX	twitching motility protein
C4E16_13515	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
C4E16_13520	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
C4E16_13525	ENOG4108UJU	UPF0301 protein
C4E16_13530	ENOG4105D7Z	glutathione synthase
C4E16_13535	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
C4E16_13540	ENOG4105RWS	endonuclease I
C4E16_13545	ENOG4105GPY	SprT protein
C4E16_13550	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
C4E16_13555	ENOG4105CV1	Transketolase (EC 2.2.1.1)
C4E16_13560	ENOG4108R4R	Iron-regulated virulence regulatory protein
C4E16_13565	ENOG4105D05	Receptor
C4E16_13570	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
C4E16_13575	ENOG4105BZA	Phosphoglycerate kinase
C4E16_13580	ENOG4105D2N	Aldolase
C4E16_13590	ENOG4105D64	Mechanosensitive ion channel
C4E16_13595	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
C4E16_13600	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
C4E16_13605	ENOG4105MPN	Membrane
C4E16_13610	ENOG4105CA9	Pyruvate kinase
C4E16_13615	ENOG410804X	Transcriptional regulator
C4E16_13620	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
C4E16_13625	ENOG4105CH5	extracellular solute-binding protein, family 7
C4E16_13670	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_13675	ENOG4105D58	Diguanylate phosphodiesterase
C4E16_13680	ENOG4105DFP	Integrase
C4E16_13690	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4E16_13695	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
C4E16_13700	ENOG4105KTH	gatB Yqey
C4E16_13705	ENOG4105VCC	30S ribosomal protein S21
C4E16_13710	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C4E16_13720	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
C4E16_13730	ENOG4107ZVW	dihydroneopterin aldolase
C4E16_13735	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4E16_13740	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
C4E16_13750	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
C4E16_13755	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
C4E16_13760	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
C4E16_13765	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
C4E16_13770	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
C4E16_13775	ENOG4108K5P	(LipO)protein
C4E16_13780	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4E16_13785	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
C4E16_13790	ENOG4105C6T	cysteine synthase
C4E16_13795	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
C4E16_13800	ENOG4108I5D	sulfate abc transporter
C4E16_13805	ENOG4105ECW	sulfate abc transporter
C4E16_13810	ENOG4108IJ6	ABC transporter
C4E16_13820	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
C4E16_13825	ENOG4105Y3E	Modulates RecA activity (By similarity)
C4E16_13830	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
C4E16_13835	ENOG4105CFH	Aspartokinase
C4E16_13840	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
C4E16_13890	ENOG4107QSA	Oxaloacetate decarboxylase
C4E16_13895	ENOG4105D9Q	decarboxylase (Beta subunit)
C4E16_13905	ENOG4105W39	Membrane
C4E16_13915	ENOG4105D9M	gamma-glutamylcysteine synthetase
C4E16_13920	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
C4E16_13925	ENOG4108JU6	CBS domain protein
C4E16_13930	ENOG4106KVJ	cytochrome C assembly protein
C4E16_13935	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4E16_13940	ENOG4105K5M	30s ribosomal protein S16
C4E16_13945	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
C4E16_13950	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
C4E16_13955	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
C4E16_13960	ENOG4105C0H	protease
C4E16_13965	ENOG4105C0H	protease
C4E16_13975	ENOG4105D6Z	AFG1 family ATPase
C4E16_13980	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
C4E16_13985	ENOG4108UJD	30S ribosomal protein S9
C4E16_13990	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
C4E16_13995	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
C4E16_14000	ENOG4105EIX	cytochrome c1
C4E16_14005	ENOG4107MKT	Stringent starvation protein a
C4E16_14010	ENOG4105KB2	stringent starvation protein b
C4E16_14015	ENOG4105W4M	Transport-associated protein
C4E16_14020	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
C4E16_14025	ENOG41082RQ	UPF0102 protein
C4E16_14030	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
C4E16_14035	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
C4E16_14045	ENOG410630P	Transcriptional regulator
C4E16_14050	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
C4E16_14055	ENOG41077A9	carbonic anhydrase
C4E16_14060	ENOG4105CHH	sulfate transporter
C4E16_14065	ENOG4105DA5	(ABC) transporter
C4E16_14070	ENOG4105E3A	(ABC) transporter
C4E16_14075	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
C4E16_14090	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
C4E16_14095	ENOG4105BZU	Histidine kinase
C4E16_14120	ENOG4107QVI	Methyltransferase, type 11
C4E16_14135	ENOG4105C2C	drug resistance transporter, Bcr CflA
C4E16_14140	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_14150	ENOG4105DZ1	carboxypeptidase
C4E16_14170	ENOG4108RS6	transposase
C4E16_14180	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4E16_14185	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
C4E16_14190	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
C4E16_14200	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
C4E16_14210	ENOG4105F2I	Transposase
C4E16_14235	ENOG4105C22	threonyL-tRNA synthetase
C4E16_14240	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
C4E16_14245	ENOG41082NX	50s ribosomal protein l35
C4E16_14250	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
C4E16_14320	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
C4E16_14360	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
C4E16_14415	ENOG4105D9U	N-acetyltransferase
C4E16_14420	ENOG4105QNF	Outer membrane lipoprotein
C4E16_14450	ENOG4105VXN	addiction module toxin, RelE StbE family
C4E16_14475	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
C4E16_14560	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
C4E16_14580	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
C4E16_14620	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
C4E16_14635	ENOG4105QNF	Outer membrane lipoprotein
C4E16_14655	ENOG4105YGK	Pfam:UPF0157
C4E16_14665	ENOG4105N14	lysine exporter protein LysE YggA
C4E16_14895	ENOG41080ET	plasmid maintenance system killer protein
C4E16_14900	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
C4E16_14925	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
C4E16_14950	ENOG4105QNF	Outer membrane lipoprotein
C4E16_15075	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
C4E16_15125	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
C4E16_15130	ENOG4105W08	virulence gene repressor rsal
C4E16_15140	ENOG4105F2I	Transposase
C4E16_15145	ENOG4105EQK	-acetyltransferase
C4E16_15165	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
C4E16_15265	ENOG4108RS6	transposase
C4E16_15335	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
C4E16_15355	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
C4E16_15360	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
C4E16_15365	ENOG4105CGF	Aromatic amino acid aminotransferase
C4E16_15370	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
C4E16_15375	ENOG4105DM4	PTS System
C4E16_15380	ENOG4105DE4	1-phosphofructokinase
C4E16_15385	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
C4E16_15390	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
C4E16_15395	ENOG4107RFY	SbcCD D subunit
C4E16_15400	ENOG4105EYH	Exonuclease
C4E16_15405	ENOG4108MGY	Histidine kinase
C4E16_15415	ENOG4107KBT	8-Amino-7-oxononanoate synthase
C4E16_15425	ENOG4105CMQ	Chloride channel
C4E16_15430	ENOG4105CKI	cobalamin synthesis protein
C4E16_15435	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
C4E16_15440	ENOG4105DFH	Transport of potassium into the cell (By similarity)
C4E16_15445	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
C4E16_15450	ENOG4105C08	Histidine kinase
C4E16_15455	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
C4E16_15460	ENOG410607N	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity)
C4E16_15465	ENOG4108RHM	integral membrane protein
C4E16_15475	ENOG4105EPM	Diguanylate phosphodiesterase
C4E16_15485	ENOG4105DS1	cytochrome b561
C4E16_15495	ENOG4105TMB	Formate nitrite transporter
C4E16_15500	ENOG4105DUM	transcriptional regulator, lysR family
C4E16_15505	ENOG4108UQ5	membrane protein YcdZ
C4E16_15510	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
C4E16_15515	ENOG4105CGH	5'-nucleotidase
C4E16_15520	ENOG4105DU1	integral membrane protein, terc
C4E16_15530	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
C4E16_15565	ENOG4105BZU	Histidine kinase
C4E16_15575	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
C4E16_15585	ENOG4105BZU	Histidine kinase
C4E16_15600	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
C4E16_15605	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
C4E16_15615	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C4E16_15635	ENOG4108ZJT	translation initiation factor, Sui1
C4E16_15645	ENOG4105CPF	Cell wall formation (By similarity)
C4E16_15655	ENOG4105CD5	CoA-binding domain protein
C4E16_15660	ENOG4105CWB	LysR family transcriptional Regulator
C4E16_15680	ENOG4105KA0	thioesterase Superfamily protein
C4E16_15705	ENOG4105CYM	Glutathione S-transferase
C4E16_15720	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
C4E16_15725	ENOG4108JQ5	ABC transporter
C4E16_15730	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
C4E16_15735	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
C4E16_15740	ENOG4105E43	Extracellular solute-binding protein, family 5
C4E16_15765	ENOG4105DUX	Transporter
C4E16_15780	ENOG4107RCV	ABC transporter, permease
C4E16_15795	ENOG4107STF	Involved in phosphonate degradation (By similarity)
C4E16_15800	ENOG4108JPW	Aminotransferase
C4E16_15805	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
C4E16_15810	ENOG4105NXH	GreA GreB family elongation factor
C4E16_15815	ENOG4105PAD	Hydrolase
C4E16_15825	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
C4E16_15830	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
C4E16_15835	ENOG4105CKU	formyltetrahydrofolate synthetase
C4E16_15840	ENOG4105E0X	reductase
C4E16_15845	ENOG4105EUJ	GTP cyclohydrolase i
C4E16_15850	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
C4E16_15855	ENOG4105D06	uba thif-type nad fad binding protein
C4E16_15865	ENOG4105KHC	sulfurtransferase
C4E16_15870	ENOG4107RHR	regulatoR
C4E16_15880	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
C4E16_15885	ENOG4105CV1	Transketolase (EC 2.2.1.1)
C4E16_15910	ENOG4108M3J	Dehydrogenase
C4E16_15925	ENOG4105RA2	Membrane
C4E16_15935	ENOG4105ETT	transcriptional Regulator, LysR family
C4E16_15940	ENOG41067V3	Antibiotic biosynthesis monooxygenase
C4E16_15975	ENOG41080HT	Transcriptional regulator, arsr family
C4E16_15985	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
C4E16_16030	ENOG4105C5Y	PTS System
C4E16_16035	ENOG4105ETE	Transcriptional regulator (LacI family
C4E16_16040	ENOG4107R3K	hydrolase
C4E16_16045	ENOG4105D7K	pfkb domain protein
C4E16_16050	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
C4E16_16055	ENOG4108NVR	Methyl-accepting chemotaxis
C4E16_16060	ENOG4108ZG0	Ompa motb domain protein
C4E16_16065	ENOG4108V1T	peptidylprolyl cis-trans isomerase
C4E16_16070	ENOG4107VXZ	Hydrolase
C4E16_16075	ENOG4108N3W	hemolysin secretion protein
C4E16_16085	ENOG4105CEE	C4-dicarboxylate transporter
C4E16_16090	ENOG4105EJQ	L-serine dehydratase
C4E16_16110	ENOG4105ETE	Transcriptional regulator (LacI family
C4E16_16115	ENOG4105WH1	Two component transcriptional regulator luxr family
C4E16_16120	ENOG4105BZU	Histidine kinase
C4E16_16135	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
C4E16_16155	ENOG4105DHT	Metal Dependent Phosphohydrolase
C4E16_16160	ENOG4108KX4	response regulator
C4E16_16165	ENOG4105BZU	Histidine kinase
C4E16_16170	ENOG4105CXY	transporter
C4E16_16175	ENOG4105C4Y	ABC transporter
C4E16_16180	ENOG4107RCV	ABC transporter, permease
C4E16_16185	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
C4E16_16190	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
C4E16_16200	ENOG4105CHU	acetyl-coa acetyltransferase
C4E16_16210	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C4E16_16215	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C4E16_16230	ENOG4105BZU	Histidine kinase
C4E16_16235	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
C4E16_16245	ENOG4108I6A	alcohol dehydrogenase
C4E16_16255	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
C4E16_16265	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
C4E16_16270	ENOG4105CXY	transporter
C4E16_16275	ENOG4105CA9	Pyruvate kinase
C4E16_16280	ENOG4105BZU	Histidine kinase
C4E16_16285	ENOG4108SV3	Tmao reductase system periplasmic protein tort
C4E16_16290	ENOG4108Z5K	methylglyoxal synthase
C4E16_16295	ENOG4108RWI	nicotinamidase
C4E16_16300	ENOG41080IJ	Diacylglycerol kinase
C4E16_16315	ENOG41088T4	Helicase IV
C4E16_16320	ENOG4105EM2	membrane
C4E16_16350	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
C4E16_16355	ENOG4105E0C	molybdate abc transporter
C4E16_16360	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
C4E16_16365	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
C4E16_16410	ENOG4105BZU	Histidine kinase
C4E16_16415	ENOG4108QGH	periplasmic
C4E16_16450	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
C4E16_16455	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
C4E16_16460	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
C4E16_16465	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
C4E16_16470	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
C4E16_16475	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
C4E16_16480	ENOG4105K63	Thioredoxin
C4E16_16510	ENOG4105DUM	transcriptional regulator, lysR family
C4E16_16515	ENOG4105DMR	ABC, transporter
C4E16_16520	ENOG4105GBT	ABC transporter
C4E16_16525	ENOG4106PMH	Extracellular solute-binding protein family 3
C4E16_16530	ENOG4105E5Z	arginine transporter ATP-binding subunit
C4E16_16540	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
C4E16_16550	ENOG4108YZ4	nudix hydrolase
C4E16_16555	ENOG4105C5W	Aldolase
C4E16_16560	ENOG4106RE7	Cytochrome
C4E16_16565	ENOG4108IG5	Transcriptional regulator
C4E16_16570	ENOG4105C1J	atp-dependent rna helicase
C4E16_16575	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
C4E16_16585	ENOG4105E0U	tyrosine-specific transport protein
C4E16_16590	ENOG4108N3W	hemolysin secretion protein
C4E16_16595	ENOG4105CMR	udp-glucose 4-epimerase
C4E16_16605	ENOG4105E7W	lamb ycsf family protein
C4E16_16615	ENOG4107R7A	Allophanate hydrolase subunit 2
C4E16_16625	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
C4E16_16630	ENOG4105CV6	ABC transporter, permease
C4E16_16635	ENOG4108I0Y	(ABC) transporter
C4E16_16645	ENOG4105RKW	reductase (By
C4E16_16665	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
C4E16_16705	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C4E16_16720	ENOG4107RE1	Inosine-guanosine kinase
C4E16_16725	ENOG4105E0M	Sulfatase
C4E16_16735	ENOG4105C1J	atp-dependent rna helicase
C4E16_16740	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
C4E16_16750	ENOG4105CVA	phosphate
C4E16_16760	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
C4E16_16765	ENOG4108M1A	Chitin-binding protein
C4E16_16770	ENOG4105D4Y	metalloprotease
C4E16_16780	ENOG4105CYW	agmatinase
C4E16_16785	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
C4E16_16795	ENOG4105CJW	magnesium transporter
C4E16_16800	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
C4E16_16805	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
C4E16_16815	ENOG4105CZK	Aspartate kinase
C4E16_16820	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
C4E16_16825	ENOG4108JPW	Aminotransferase
C4E16_16830	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
C4E16_16835	ENOG41090A4	Pterin carbinolamine dehydratase
C4E16_16840	ENOG4105MIR	Phenylalanine 4-monooxygenase
C4E16_16845	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
C4E16_16865	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
C4E16_16870	ENOG4105EGI	Transcriptional regulator
C4E16_16885	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
C4E16_16890	ENOG4105C37	(CBS) domain
C4E16_16895	ENOG4108UKZ	OsmC family
C4E16_16900	ENOG4107YWA	deoxycytidylate deaminase
C4E16_16920	ENOG4105DVH	amino acid
C4E16_16925	ENOG4106TD9	Diguanylate cyclase
C4E16_16935	ENOG4108VAC	response regulator
C4E16_16940	ENOG4108HRK	Histidine kinase
C4E16_16955	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C4E16_16960	ENOG4105C19	ABC transporter
C4E16_16975	ENOG4107RGM	aldo keto reductase
C4E16_16980	ENOG4107T9C	Alpha amylase catalytic region
C4E16_16990	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
C4E16_16995	ENOG4108M0H	Extracellular lipase
C4E16_17000	ENOG4107SDU	Methyl-accepting chemotaxis
C4E16_17005	ENOG4105D4Y	metalloprotease
C4E16_17015	ENOG4105EIF	outer membrane protein W
C4E16_17025	ENOG41061WM	D-Alanyl-D-Alanine
C4E16_17030	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
C4E16_17035	ENOG4105C4M	(Ubiquinol oxidase) subunit I
C4E16_17040	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
C4E16_17055	ENOG4105BZC	d-serine deaminase
C4E16_17060	ENOG4105W8I	Transcriptional regulator
C4E16_17110	ENOG4105CPQ	Dehydrogenase
C4E16_17115	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
C4E16_17135	ENOG4105EXG	Transcriptional regulator
C4E16_17140	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
C4E16_17160	ENOG4107SSZ	Phosphatase
C4E16_17165	ENOG4105DHT	Metal Dependent Phosphohydrolase
C4E16_17170	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
C4E16_17175	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
C4E16_17180	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
C4E16_17205	ENOG4105BZW	Glycerate kinase
C4E16_17210	ENOG4105C6Z	Gluconate
C4E16_17215	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
C4E16_17220	ENOG4108NVR	Methyl-accepting chemotaxis
C4E16_17225	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
C4E16_17230	ENOG41090JE	Utilization Protein
C4E16_17235	ENOG4105D4P	Coproporphyrinogen iii oxidase
C4E16_17240	ENOG4105WQ5	TonB family
C4E16_17245	ENOG41090AP	transport protein
C4E16_17250	ENOG4106GFD	transport protein
C4E16_17255	ENOG4107R4I	Periplasmic binding protein
C4E16_17260	ENOG4105EHG	Permease protein
C4E16_17265	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
C4E16_17295	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_17300	ENOG4105QVC	MOSC domain-containing protein
C4E16_17300	ENOG4105QVC	MOSC domain-containing protein
C4E16_17310	ENOG4105EKE	dihydroorotase
C4E16_17320	ENOG4105KAF	membrAne
C4E16_17330	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
C4E16_17335	ENOG4105CKW	Inner membrane protein yedI
C4E16_17340	ENOG4108ESY	Metal dependent phosphohydrolase
C4E16_17345	ENOG4105VEQ	Cold shock protein
C4E16_17375	ENOG4105BZU	Histidine kinase
C4E16_17380	ENOG4105E98	transcriptional regulator DeoR family
C4E16_17395	ENOG4105EG2	ABC transporter, permease
C4E16_17400	ENOG4105D56	permease protein
C4E16_17405	ENOG4107FKK	extracellular solute-binding protein family 1
C4E16_17410	ENOG4108IJ9	(ABC) transporter
C4E16_17415	ENOG4108HK0	-acetyltransferase
C4E16_17430	ENOG4105K8R	UPF0145 protein
C4E16_17435	ENOG41086KC	Transcriptional regulator
C4E16_17440	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
C4E16_17445	ENOG4107R88	Chemotaxis protein (CheV)
C4E16_17450	ENOG4105K56	Transcriptional regulator
C4E16_17455	ENOG4106TD9	Diguanylate cyclase
C4E16_17475	ENOG4105BZU	Histidine kinase
C4E16_17495	ENOG4105ETT	transcriptional Regulator, LysR family
C4E16_17500	ENOG4108K0B	C-di-gmp phosphodiesterase
C4E16_17510	ENOG4105EUB	pirin domain protein
C4E16_17515	ENOG4105NBK	UPF0345 protein
C4E16_17525	ENOG4105E5W	Transporter
C4E16_17535	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_17540	ENOG4105DAN	ATP-dependent protease
C4E16_17550	ENOG4108JQ5	ABC transporter
C4E16_17555	ENOG4105E89	ABC transporter
C4E16_17560	ENOG4107SDU	Methyl-accepting chemotaxis
C4E16_17575	ENOG4105CC0	LysR family Transcriptional regulator
C4E16_17580	ENOG4105DAA	L-lactate
C4E16_17585	ENOG4105DMF	Dehydrogenase
C4E16_17595	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
C4E16_17605	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
C4E16_17615	ENOG4105C1J	atp-dependent rna helicase
C4E16_17620	ENOG4105CR8	Transcriptional regulator
C4E16_17630	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
C4E16_17640	ENOG4105BZ1	(ABC) transporter
C4E16_17650	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
C4E16_17685	ENOG4105K56	Transcriptional regulator
C4E16_17690	ENOG4108ZHJ	Organic hydroperoxide resistance protein
C4E16_17700	ENOG4108SXK	Transporter Drug Metabolite Exporter family
C4E16_17705	ENOG4105VW4	glutaredoxin 3
C4E16_17710	ENOG4108P2H	Inner membrane protein YjiG
C4E16_17715	ENOG41074DU	domain protein
C4E16_17720	ENOG4105DN9	Na H antiporter
C4E16_17730	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
C4E16_17735	ENOG4105D03	DNA-3-methyladenine glycosylase II
C4E16_17740	ENOG4108VGI	doxx family
C4E16_17765	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
C4E16_17775	ENOG4107W52	maltose operon periplasmic protein
C4E16_17780	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
C4E16_17795	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_17810	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_17820	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
C4E16_17825	ENOG4105CDA	abc transporter atp-binding protein
C4E16_17835	ENOG4106TNF	Periplasmic binding protein
C4E16_17840	ENOG4105EZ7	amino acid ABC transporter
C4E16_17845	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
C4E16_17855	ENOG4105DR5	peptidase
C4E16_17865	ENOG4105CTS	PTS system mannitol-specific
C4E16_17870	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
C4E16_17875	ENOG4105E61	Mannitol repressor protein
C4E16_17880	ENOG4105EP9	oxidoreductase
C4E16_17910	ENOG4108RYK	Nad-dependent epimerase dehydratase
C4E16_17915	ENOG4105JQN	Transcriptional regulator
C4E16_17920	ENOG41069D7	Methyl-accepting chemotaxis
C4E16_17930	ENOG4105EMU	Dehydrogenase
C4E16_17935	ENOG4105JQN	Transcriptional regulator
C4E16_17945	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
C4E16_17955	ENOG4105D5Q	Arginine ornithine antiporter
C4E16_17960	ENOG4105CXN	decarboxylase
C4E16_17975	ENOG4107RGH	Aldehyde dehydrogenase
C4E16_17980	ENOG4105EW9	transcriptional regulator AsnC family
C4E16_17985	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_17995	ENOG4105CK7	Sodium proline symporter
C4E16_18005	ENOG4105C26	Dehydrogenase
C4E16_18020	ENOG4105E6M	Sulphatase-modifying factor protein
C4E16_18030	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
C4E16_18035	ENOG4107QZV	Type I secretion membrane fusion protein
C4E16_18050	ENOG4108JJA	ABC, transporter
C4E16_18060	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C4E16_18070	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_18075	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
C4E16_18080	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
C4E16_18085	ENOG4105BZU	Histidine kinase
C4E16_18090	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_18095	ENOG4108V3W	Chemotaxis protein, CheW
C4E16_18100	ENOG4108V3W	Chemotaxis protein, CheW
C4E16_18110	ENOG4108VYJ	response regulator receiver protein
C4E16_18125	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
C4E16_18130	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
C4E16_18135	ENOG4108JQ6	ABC transporter
C4E16_18140	ENOG4105DIJ	Phosphoethanolamine transferase
C4E16_18145	ENOG4105DHQ	Histidine kinase
C4E16_18150	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
C4E16_18180	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
C4E16_18185	ENOG4107RUE	extracellular solute-binding protein family 1
C4E16_18190	ENOG4106RMF	ParB family
C4E16_18225	ENOG4105CDY	transcriptional regulatory protein
C4E16_18230	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
C4E16_18235	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_18245	ENOG4108YYI	Protein of unknown function (DUF2810)
C4E16_18250	ENOG41061ZR	Transcriptional regulator
C4E16_18255	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
C4E16_18260	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
C4E16_18265	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
C4E16_18275	ENOG4108WC9	type VI secretion system effector, hcp1 family
C4E16_18280	ENOG4105CS6	Rhs element vgr protein
C4E16_18305	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C4E16_18315	ENOG4105C8P	)-transporter
C4E16_18320	ENOG4108Q67	UPF0319 protein
C4E16_18345	ENOG4105C8Q	Methyl-accepting chemotaxis
C4E16_18365	ENOG4105EYK	Phosphatidylglycerophosphatase B
C4E16_18370	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
C4E16_18395	ENOG4105D6U	Sodium Glutamate Symporter
C4E16_18400	ENOG4105YE1	PilZ domain
C4E16_18415	ENOG4105EFX	secretion protein, HlyD family
C4E16_18420	ENOG4105KK7	inner membrane protein YiaW
C4E16_18425	ENOG4106TD9	Diguanylate cyclase
C4E16_18440	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
C4E16_18450	ENOG4107SEY	Conserved Protein
C4E16_18460	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
C4E16_18465	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
C4E16_18475	ENOG4105C1J	atp-dependent rna helicase
C4E16_18480	ENOG4105CUG	Oligopeptidase b
C4E16_18510	ENOG4105CVA	phosphate
C4E16_18515	ENOG4105C8U	phosphate abc transporter
C4E16_18520	ENOG4105E2Z	phosphate ABC transporter (Permease
C4E16_18525	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C4E16_18530	ENOG4105BZU	Histidine kinase
C4E16_18545	ENOG4105DWD	nucleoside recognition domain protein
C4E16_18550	ENOG4105CHH	sulfate transporter
C4E16_18560	ENOG4105DR5	peptidase
C4E16_18565	ENOG4105BZU	Histidine kinase
C4E16_18570	ENOG4105EQ2	LysR family Transcriptional regulator
C4E16_18575	ENOG4105E5M	Multidrug resistance protein D
C4E16_18580	ENOG4108Z4X	TRANSCRIPTIONal
C4E16_18600	ENOG4105CK2	sodium dicarboxylate symporter
C4E16_18645	ENOG4107RH7	Nicotinate phosphoribosyltransferase
C4E16_18650	ENOG4105D9R	oxidoreductase
C4E16_18660	ENOG4105BZU	Histidine kinase
C4E16_18665	ENOG4107VXZ	Hydrolase
C4E16_18675	ENOG4105D3G	Pseudouridine synthase
C4E16_18735	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C4E16_18740	ENOG4108JUB	Transcriptional regulator
C4E16_18770	ENOG4105CS6	Rhs element vgr protein
C4E16_18785	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
C4E16_18790	ENOG4105C2J	ABC transporter
C4E16_18795	ENOG4105CNN	ABC, transporter
C4E16_18800	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
C4E16_18805	ENOG4108RVA	ribokinase
C4E16_18810	ENOG4105ETE	Transcriptional regulator (LacI family
C4E16_18815	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
C4E16_18820	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
C4E16_18825	ENOG4108I5U	Uridine phosphorylase
C4E16_18835	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
C4E16_18840	ENOG4105CXY	transporter
C4E16_18855	ENOG4105CQZ	Histidine kinase
C4E16_18860	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4E16_18880	ENOG4105D5U	fad dependent oxidoreductase
C4E16_18890	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
C4E16_18900	ENOG4105KJM	monovalent cation h antiporter subunit g
C4E16_18905	ENOG41080TA	Multiple resistance and ph regulation protein f
C4E16_18910	ENOG4105SC1	monovalent cation H antiporter subunit E
C4E16_18915	ENOG4108JPZ	Monovalent cation H antiporter subunit D
C4E16_18920	ENOG4105MKQ	Monovalent cation H antiporter subunit C
C4E16_18925	ENOG4105D65	subunit l
C4E16_18935	ENOG4105Q9Y	Universal stress protein
C4E16_18940	ENOG4105CIC	tryptophan-specific transport protein
C4E16_18945	ENOG4105C0F	tryptophanase EC 4.1.99.1
C4E16_18955	ENOG4105VRT	cytoplasmic protein
C4E16_18965	ENOG4105BZU	Histidine kinase
C4E16_18970	ENOG4105VEQ	Cold shock protein
C4E16_19005	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
C4E16_19010	ENOG41069D7	Methyl-accepting chemotaxis
C4E16_19025	ENOG4105D9N	nucleoside
C4E16_19030	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
C4E16_19040	ENOG4108JUA	Transcriptional regulator
C4E16_19045	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
C4E16_19050	ENOG4105VEQ	Cold shock protein
C4E16_19070	ENOG4108UNF	response regulator
C4E16_19080	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
C4E16_19085	ENOG4105C5I	Dehydrogenase
C4E16_19110	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
C4E16_19135	ENOG4108RS6	transposase
C4E16_19150	ENOG4105C1J	atp-dependent rna helicase
C4E16_19155	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
C4E16_19160	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
C4E16_19165	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
C4E16_19175	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C4E16_19180	ENOG4105BZU	Histidine kinase
C4E16_19190	ENOG4107S6Z	Na H antiporter
C4E16_19195	ENOG4105E5M	Multidrug resistance protein D
C4E16_19205	ENOG4105BZU	Histidine kinase
C4E16_19210	ENOG4105KUU	lipolytic protein G-D-S-L family
C4E16_19215	ENOG4106M3D	hemolysin
C4E16_19220	ENOG4108N3W	hemolysin secretion protein
C4E16_19225	ENOG4107IFA	Lipase (EC 3.1.1.3)
C4E16_19235	ENOG4107G87	m6 family metalloprotease domain protein
C4E16_19255	ENOG4105DHS	permease protein
C4E16_19260	ENOG4105CM4	permease protein
C4E16_19265	ENOG4108IPW	abc transporter atp-binding protein
C4E16_19285	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
C4E16_19305	ENOG4105ETX	regulatoR
C4E16_19315	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
C4E16_19325	ENOG410667J	hydrolase
C4E16_19355	ENOG4105DS1	cytochrome b561