locus-tag	class	description
GTH07_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GTH07_00010	COG0592	DNA-directed DNA polymerase activity
GTH07_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTH07_00020	COG0187	DNA topoisomerase II activity
GTH07_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
GTH07_00035	COG3977	Valine--pyruvate aminotransferase
GTH07_00040	COG0751	glycine-tRNA ligase activity
GTH07_00045	COG0752	glycyl-tRNA synthetase alpha subunit
GTH07_00050	COG2119	membrane
GTH07_00060	COG0425	Belongs to the sulfur carrier protein TusA family
GTH07_00070	COG0604	alcohol dehydrogenase
GTH07_00080	COG0129	dihydroxy-acid dehydratase activity
GTH07_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTH07_00100	COG0606	chelatase, subunit chli
GTH07_00105	COG0204	Acyl-transferase
GTH07_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTH07_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTH07_00125	COG3084	Protein conserved in bacteria
GTH07_00130	COG4326	sporulation control protein
GTH07_00135	COG1272	protein, Hemolysin III
GTH07_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTH07_00150	COG0569	domain protein
GTH07_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTH07_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTH07_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GTH07_00165	COG0242	peptide deformylase activity
GTH07_00170	COG1652	LysM domain
GTH07_00175	COG0758	DNA mediated transformation
GTH07_00180	COG2922	Belongs to the Smg family
GTH07_00185	COG0551	DNA topoisomerase type I activity
GTH07_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GTH07_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GTH07_00200	COG0009	L-threonylcarbamoyladenylate synthase
GTH07_00205	COG0408	coproporphyrinogen oxidase activity
GTH07_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GTH07_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTH07_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTH07_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GTH07_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTH07_00280	COG2104	thiamine diphosphate biosynthetic process
GTH07_00285	COG2022	thiamine diphosphate biosynthetic process
GTH07_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTH07_00295	COG0006	proline dipeptidase activity
GTH07_00295	COG0006	proline dipeptidase activity
GTH07_00315	COG1522	sequence-specific DNA binding
GTH07_00320	COG5001	Diguanylate cyclase
GTH07_00320	COG5002	protein histidine kinase activity
GTH07_00340	COG0589	response to stress
GTH07_00345	COG1528	Iron-storage protein
GTH07_00355	COG2081	HI0933 family
GTH07_00365	COG1322	Protein conserved in bacteria
GTH07_00370	COG2226	methyltransferase
GTH07_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTH07_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTH07_00395	COG0805	protein transport
GTH07_00400	COG1858	cytochrome C peroxidase
GTH07_00405	COG0534	Mate efflux family protein
GTH07_00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTH07_00420	COG2937	Belongs to the GPAT DAPAT family
GTH07_00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GTH07_00430	COG3161	chorismate lyase activity
GTH07_00435	COG1580	Controls the rotational direction of flagella during chemotaxis
GTH07_00440	COG0840	transmembrane signaling receptor activity
GTH07_00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTH07_00455	COG0084	hydrolase, TatD family'
GTH07_00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTH07_00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTH07_00490	COG3078	GTPase activator activity
GTH07_00505	COG3071	HemY protein
GTH07_00510	COG2959	enzyme of heme biosynthesis
GTH07_00515	COG1587	Uroporphyrinogen-III synthase
GTH07_00520	COG0181	hydroxymethylbilane synthase activity
GTH07_00530	COG1965	Belongs to the frataxin family
GTH07_00540	COG0019	diaminopimelate decarboxylase activity
GTH07_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GTH07_00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GTH07_00560	COG1011	Hydrolase
GTH07_00565	COG2199	diguanylate cyclase activity
GTH07_00565	COG2200	EAL domain
GTH07_00565	COG3287	FIST C domain
GTH07_00580	COG0561	phosphatase activity
GTH07_00585	COG2267	carboxylic ester hydrolase activity
GTH07_00590	COG1280	lysine exporter protein (LysE YggA)
GTH07_00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTH07_00600	COG0783	Belongs to the Dps family
GTH07_00630	COG0742	ribosomal rna small subunit methyltransferase
GTH07_00635	COG0552	protein localization to endoplasmic reticulum
GTH07_00640	COG2884	Cell division ATP-binding protein ftsE
GTH07_00645	COG2177	Part of the ABC transporter FtsEX involved in
GTH07_00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTH07_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTH07_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTH07_00675	COG4206	TonB-dependent receptor
GTH07_00680	COG1404	Belongs to the peptidase S8 family
GTH07_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTH07_00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GTH07_00755	COG5001	Diguanylate cyclase
GTH07_00755	COG3300	MHYT domain
GTH07_00765	COG3852	Histidine kinase
GTH07_00775	COG0174	glutamine synthetase
GTH07_00785	COG1217	gtp-binding protein TYPA
GTH07_00795	COG1295	ribonuclease BN
GTH07_00800	COG1490	D-aminoacyl-tRNA deacylase activity
GTH07_00805	COG0456	acetyltransferase
GTH07_00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GTH07_00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GTH07_00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTH07_00830	COG3031	protein transport across the cell outer membrane
GTH07_00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTH07_00845	COG1459	type II secretion system
GTH07_00850	COG2165	general secretion pathway protein
GTH07_00855	COG2165	general secretion pathway protein
GTH07_00860	COG2165	general secretion pathway protein
GTH07_00865	COG4795	General secretion pathway protein
GTH07_00870	COG3156	type II secretion system protein K
GTH07_00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GTH07_00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GTH07_00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
GTH07_00895	COG0494	nUDIX hydrolase
GTH07_00905	COG1040	competence protein
GTH07_00915	COG0596	Alpha beta hydrolase
GTH07_00925	COG2183	response to ionizing radiation
GTH07_00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTH07_00945	COG2233	PERMEase
GTH07_00950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTH07_00955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTH07_00960	COG1758	RNA polymerase activity
GTH07_00965	COG0194	GDP metabolic process
GTH07_00970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GTH07_00975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTH07_00985	COG3263	regulation of cellular component size
GTH07_00995	COG4232	protein-disulfide reductase activity
GTH07_01005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTH07_01010	COG1027	Aspartate ammonia-lyase
GTH07_01015	COG3706	GGDEF domain
GTH07_01020	COG3030	protein affecting phage T7 exclusion by the F plasmid
GTH07_01025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GTH07_01035	COG2205	protein histidine kinase activity
GTH07_01040	COG0745	RESPONSE REGULATOR receiver
GTH07_01050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTH07_01055	COG0205	6-phosphofructokinase activity
GTH07_01060	COG1494	fructose-1,6-bisphosphatase
GTH07_01065	COG3074	FtsZ-dependent cytokinesis
GTH07_01070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GTH07_01075	COG0460	homoserine dehydrogenase
GTH07_01075	COG0527	aspartate kinase activity
GTH07_01080	COG0626	cystathionine gamma-synthase activity
GTH07_01085	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GTH07_01090	COG0281	malic enzyme
GTH07_01095	COG0254	rRNA binding
GTH07_01100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTH07_01105	COG1609	Transcriptional regulator
GTH07_01110	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTH07_01115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GTH07_01120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GTH07_01125	COG1575	Belongs to the MenA family. Type 1 subfamily
GTH07_01130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTH07_01135	COG0534	Mate efflux family protein
GTH07_01140	COG0149	triose-phosphate isomerase activity
GTH07_01165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTH07_01170	COG0459	protein refolding
GTH07_01180	COG1509	lysine 2,3-aminomutase activity
GTH07_01185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTH07_01195	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GTH07_01200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GTH07_01205	COG1053	succinate dehydrogenase
GTH07_01210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GTH07_01215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTH07_01220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GTH07_01225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GTH07_01230	COG1045	serine acetyltransferase
GTH07_01240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GTH07_01245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTH07_01250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GTH07_01255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GTH07_01260	COG0137	argininosuccinate synthase activity
GTH07_01265	COG0165	Argininosuccinate lyase
GTH07_01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTH07_01280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTH07_01280	COG0678	peroxiredoxin activity
GTH07_01290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GTH07_01320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GTH07_01325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GTH07_01335	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GTH07_01340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTH07_01345	COG0546	phosphoglycolate phosphatase activity
GTH07_01350	COG0180	Tryptophanyl-tRNA synthetase
GTH07_01365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTH07_01375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTH07_01385	COG1012	belongs to the aldehyde dehydrogenase family
GTH07_01400	COG3954	Phosphoribulokinase
GTH07_01410	COG0429	hydrolase of the alpha beta-hydrolase fold
GTH07_01420	COG0488	(ABC) transporter
GTH07_01425	COG2249	NAD(P)H dehydrogenase (quinone) activity
GTH07_01440	COG1047	Peptidyl-prolyl cis-trans
GTH07_01455	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GTH07_01460	COG3083	sulfuric ester hydrolase activity
GTH07_01465	COG0557	exoribonuclease II activity
GTH07_01470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTH07_01475	COG0051	transcription antitermination factor activity, RNA binding
GTH07_01480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GTH07_01485	COG0088	Forms part of the polypeptide exit tunnel
GTH07_01490	COG0089	rRNA binding
GTH07_01495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GTH07_01500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GTH07_01505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GTH07_01510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GTH07_01515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTH07_01520	COG0255	Belongs to the universal ribosomal protein uL29 family
GTH07_01525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GTH07_01530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GTH07_01535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GTH07_01540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GTH07_01545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GTH07_01550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GTH07_01555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GTH07_01560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GTH07_01565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GTH07_01570	COG1841	ribosomal large subunit assembly
GTH07_01575	COG0200	Binds to the 23S rRNA
GTH07_01580	COG0201	protein transport
GTH07_01585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTH07_01590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GTH07_01595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GTH07_01600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GTH07_01605	COG0202	RNA polymerase activity
GTH07_01610	COG0203	ribosomal protein L17
GTH07_01630	COG0545	Peptidyl-prolyl cis-trans isomerase
GTH07_01635	COG3266	domain, Protein
GTH07_01635	COG3061	Opacity-associated protein A
GTH07_01640	COG0697	spore germination
GTH07_01645	COG2153	protein acetylation
GTH07_01650	COG0513	Belongs to the DEAD box helicase family
GTH07_01660	COG0737	Belongs to the 5'-nucleotidase family
GTH07_01665	COG1648	precorrin-2 dehydrogenase activity
GTH07_01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTH07_01670	COG0175	sulfate reduction
GTH07_01675	COG2895	sulfate adenylyltransferase (ATP) activity
GTH07_01680	COG0529	Catalyzes the synthesis of activated sulfate
GTH07_01700	COG1136	(ABC) transporter
GTH07_01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GTH07_01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTH07_01725	COG0729	surface antigen
GTH07_01735	COG2105	PFAM AIG2 family protein
GTH07_01740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GTH07_01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTH07_01755	COG0163	prenyltransferase activity
GTH07_01765	COG1178	ABC-type Fe3 transport system permease component
GTH07_01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GTH07_01775	COG3028	Belongs to the UPF0307 family
GTH07_01780	COG0312	modulator of DNA gyrase
GTH07_01785	COG2239	Acts as a magnesium transporter
GTH07_01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH07_01795	COG1660	Displays ATPase and GTPase activities
GTH07_01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH07_01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTH07_01815	COG1137	ATPase activity
GTH07_01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GTH07_01835	COG0517	IMP dehydrogenase activity
GTH07_01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GTH07_01845	COG1127	ABC transporter
GTH07_01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GTH07_01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTH07_01860	COG2854	intermembrane phospholipid transfer
GTH07_01870	COG5007	Belongs to the BolA IbaG family
GTH07_01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTH07_01885	COG0251	oxidation-reduction process
GTH07_01890	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GTH07_01895	COG0540	Belongs to the ATCase OTCase family
GTH07_01905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GTH07_01910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTH07_01915	COG0564	pseudouridine synthase activity
GTH07_01920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTH07_01925	COG0525	valine-tRNA ligase activity
GTH07_01930	COG2927	DNA polymerase III (CHI subunit)
GTH07_01935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTH07_01940	COG0795	lipopolysaccharide-transporting ATPase activity
GTH07_01945	COG0795	lipopolysaccharide-transporting ATPase activity
GTH07_01960	COG3437	response regulator, receiver
GTH07_02005	COG0066	3-isopropylmalate dehydratase activity
GTH07_02010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GTH07_02015	COG0473	3-isopropylmalate dehydrogenase activity
GTH07_02040	COG0583	DNA-binding transcription factor activity
GTH07_02045	COG1022	Amp-dependent synthetase and ligase
GTH07_02050	COG0028	Belongs to the TPP enzyme family
GTH07_02055	COG0440	acetolactate synthase activity
GTH07_02060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTH07_02065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GTH07_02070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTH07_02080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GTH07_02085	COG3079	Belongs to the UPF0149 family
GTH07_02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTH07_02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTH07_02105	COG0354	folic acid binding
GTH07_02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GTH07_02120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GTH07_02125	COG1595	DNA-templated transcription, initiation
GTH07_02135	COG3026	antisigma factor binding
GTH07_02140	COG3086	response to oxidative stress
GTH07_02145	COG0481	GTPase activity
GTH07_02155	COG0571	ribonuclease III activity
GTH07_02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GTH07_02165	COG1381	Involved in DNA repair and RecF pathway recombination
GTH07_02170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GTH07_02175	COG0736	holo-[acyl-carrier-protein] synthase activity
GTH07_02200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTH07_02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTH07_02210	COG3956	TIGRFAM MazG family protein
GTH07_02215	COG0504	CTP synthase activity
GTH07_02220	COG0148	phosphopyruvate hydratase activity
GTH07_02225	COG0617	tRNA 3'-terminal CCA addition
GTH07_02240	COG4991	sh3 domain protein
GTH07_02245	COG0306	phosphate transporter
GTH07_02250	COG1392	Phosphate transport regulator
GTH07_02255	COG3025	triphosphatase activity
GTH07_02265	COG0840	transmembrane signaling receptor activity
GTH07_02270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GTH07_02275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GTH07_02275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GTH07_02280	COG1538	Outer membrane efflux protein
GTH07_02285	COG0494	nUDIX hydrolase
GTH07_02290	COG3151	Protein conserved in bacteria
GTH07_02300	COG3150	esterase
GTH07_02305	COG0187	DNA topoisomerase II activity
GTH07_02310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTH07_02320	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GTH07_02325	COG0237	dephospho-CoA kinase activity
GTH07_02335	COG1459	type II secretion system
GTH07_02340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTH07_02360	COG0716	FMN binding
GTH07_02365	COG4974	Belongs to the 'phage' integrase family
GTH07_02370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTH07_02375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTH07_02380	COG0737	Belongs to the 5'-nucleotidase family
GTH07_02385	COG2186	Transcriptional regulator
GTH07_02390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GTH07_02395	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTH07_02400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTH07_02415	COG3116	cell division
GTH07_02420	COG0768	penicillin binding
GTH07_02425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTH07_02430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTH07_02440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTH07_02445	COG0772	Belongs to the SEDS family
GTH07_02450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTH07_02455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTH07_02460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GTH07_02465	COG0849	cell division
GTH07_02470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTH07_02475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GTH07_02485	COG0653	protein targeting
GTH07_02490	COG0494	nUDIX hydrolase
GTH07_02495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GTH07_02505	COG0505	Belongs to the CarA family
GTH07_02510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTH07_02530	COG0730	response to heat
GTH07_02535	COG0583	DNA-binding transcription factor activity
GTH07_02540	COG2860	membrane
GTH07_02545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTH07_02555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GTH07_02565	COG0493	'glutamate synthase
GTH07_02570	COG0067	glutamate synthase
GTH07_02570	COG0069	glutamate synthase activity
GTH07_02570	COG0070	glutamate synthase
GTH07_02580	COG0067	glutamate synthase
GTH07_02580	COG0070	glutamate synthase
GTH07_02580	COG0069	glutamate synthase activity
GTH07_02585	COG1242	4 iron, 4 sulfur cluster binding
GTH07_02590	COG5001	Diguanylate cyclase
GTH07_02590	COG4251	negative regulation of phosphorylation
GTH07_02590	COG3706	GGDEF domain
GTH07_02590	COG2203	Gaf domain
GTH07_02595	COG5002	protein histidine kinase activity
GTH07_02595	COG2198	Histidine kinase
GTH07_02595	COG0784	Response regulator, receiver
GTH07_02600	COG0745	RESPONSE REGULATOR receiver
GTH07_02610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTH07_02630	COG0083	homoserine kinase activity
GTH07_02635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GTH07_02640	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GTH07_02645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GTH07_02650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GTH07_02665	COG1115	amino acid carrier protein
GTH07_02670	COG3022	response to hydroperoxide
GTH07_02680	COG0084	hydrolase, TatD family'
GTH07_02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTH07_02695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GTH07_02700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GTH07_02705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GTH07_02710	COG0813	purine-nucleoside phosphorylase activity
GTH07_02720	COG0560	Phosphoserine phosphatase
GTH07_02730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GTH07_02735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTH07_02740	COG1022	Amp-dependent synthetase and ligase
GTH07_02755	COG3250	beta-galactosidase activity
GTH07_02760	COG1609	Transcriptional regulator
GTH07_02765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTH07_02780	COG0569	domain protein
GTH07_02780	COG0189	ligase activity
GTH07_02785	COG0456	acetyltransferase
GTH07_02795	COG2171	N-acyltransferase activity
GTH07_02800	COG3141	response to X-ray
GTH07_02815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GTH07_02820	COG1074	ATP-dependent DNA helicase activity
GTH07_02825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTH07_02835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GTH07_02835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GTH07_02845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GTH07_02850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GTH07_02855	COG2166	iron-sulfur cluster assembly
GTH07_02860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTH07_02865	COG0693	protein deglycase activity
GTH07_02870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTH07_02875	COG3248	Nucleoside-binding outer membrane protein
GTH07_02885	COG1595	DNA-templated transcription, initiation
GTH07_02895	COG2211	Major facilitator Superfamily
GTH07_02900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTH07_02910	COG2813	Specifically methylates the guanine in position
GTH07_02915	COG0271	Belongs to the BolA IbaG family
GTH07_02920	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTH07_02925	COG1805	sodium ion transport
GTH07_02930	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTH07_02935	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTH07_02940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTH07_02945	COG2871	sodium ion transport
GTH07_02950	COG1477	protein flavinylation
GTH07_02970	COG3706	GGDEF domain
GTH07_02975	COG0733	neurotransmitter:sodium symporter activity
GTH07_02985	COG0189	ligase activity
GTH07_02990	COG4067	protein conserved in archaea
GTH07_02990	COG0189	ligase activity
GTH07_02995	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTH07_03000	COG2252	PERMEase
GTH07_03005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GTH07_03010	COG1073	alpha beta
GTH07_03020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GTH07_03025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GTH07_03030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GTH07_03035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTH07_03035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTH07_03050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GTH07_03055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTH07_03060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GTH07_03065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTH07_03075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GTH07_03080	COG0024	Methionine aminopeptidase
GTH07_03085	COG0052	Belongs to the universal ribosomal protein uS2 family
GTH07_03090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GTH07_03095	COG0528	UMP kinase activity
GTH07_03100	COG0233	cytoplasmic translational termination
GTH07_03105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GTH07_03110	COG0575	Belongs to the CDS family
GTH07_03115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GTH07_03120	COG0750	zinc metalloprotease
GTH07_03130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GTH07_03135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTH07_03140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTH07_03145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTH07_03150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTH07_03155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTH07_03160	COG0587	DNA-directed DNA polymerase activity
GTH07_03165	COG0825	malonyl-CoA metabolic process
GTH07_03170	COG0037	tRNA processing
GTH07_03180	COG3479	Phenolic acid decarboxylase
GTH07_03185	COG0347	Belongs to the P(II) protein family
GTH07_03190	COG3021	interspecies interaction between organisms
GTH07_03195	COG0741	lytic transglycosylase activity
GTH07_03195	COG1388	LysM domain
GTH07_03200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTH07_03205	COG2226	methyltransferase
GTH07_03210	COG0328	RNA-DNA hybrid ribonuclease activity
GTH07_03225	COG1960	acyl-CoA dehydrogenase activity
GTH07_03230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GTH07_03235	COG0121	glutamine amidotransferase
GTH07_03240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GTH07_03245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GTH07_03250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GTH07_03260	COG1187	pseudouridine synthase activity
GTH07_03265	COG2840	Smr protein MutS2
GTH07_03280	COG3735	TraB family
GTH07_03295	COG2608	mercury ion transmembrane transporter activity
GTH07_03295	COG2217	Heavy metal translocating P-type atpase
GTH07_03300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTH07_03315	COG4774	siderophore transport
GTH07_03315	COG1629	transport
GTH07_03320	COG2375	cellular response to nickel ion
GTH07_03325	COG3433	isochorismatase activity
GTH07_03325	COG2226	methyltransferase
GTH07_03325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTH07_03360	COG0835	chemotaxis
GTH07_03360	COG0784	Response regulator, receiver
GTH07_03365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTH07_03370	COG1815	bacterial-type flagellum-dependent cell motility
GTH07_03385	COG1749	Flagellar hook protein flgE
GTH07_03390	COG4787	bacterial-type flagellum-dependent cell motility
GTH07_03400	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GTH07_03405	COG1706	bacterial-type flagellum-dependent cell motility
GTH07_03410	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTH07_03410	COG3951	Flagellar rod assembly protein muramidase FlgJ
GTH07_03425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTH07_03430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTH07_03520	COG0012	GTP binding
GTH07_03525	COG0193	aminoacyl-tRNA hydrolase activity
GTH07_03530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GTH07_03535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GTH07_03540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GTH07_03545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GTH07_03550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GTH07_03555	COG2890	protein-(glutamine-N5) methyltransferase activity
GTH07_03565	COG2912	Transglutaminase-like superfamily
GTH07_03570	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GTH07_03575	COG0737	Belongs to the 5'-nucleotidase family
GTH07_03580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTH07_03585	COG2233	PERMEase
GTH07_03605	COG1393	Belongs to the ArsC family
GTH07_03610	COG4783	chaperone-mediated protein folding
GTH07_03630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GTH07_03640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTH07_03645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GTH07_03655	COG1876	peptidase activity
GTH07_03665	COG1393	Belongs to the ArsC family
GTH07_03685	COG2837	iron assimilation
GTH07_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTH07_03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTH07_03700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTH07_03705	COG1334	flagellar protein FlaG
GTH07_03710	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GTH07_03720	COG1516	flagellar protein fliS
GTH07_03740	COG1677	Flagellar hook-basal body complex protein FliE
GTH07_03750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTH07_03755	COG1317	bacterial-type flagellum organization
GTH07_03780	COG1580	Controls the rotational direction of flagella during chemotaxis
GTH07_03805	COG1987	bacterial-type flagellum assembly
GTH07_03810	COG1684	flagellar biosynthetic protein fliR
GTH07_03820	COG2840	Smr protein MutS2
GTH07_03825	COG2890	protein-(glutamine-N5) methyltransferase activity
GTH07_03830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GTH07_03835	COG2860	membrane
GTH07_03840	COG3101	peptidyl-lysine hydroxylation
GTH07_03850	COG0431	NADPH-dependent FMN reductase
GTH07_03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTH07_03855	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GTH07_03860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTH07_03865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTH07_03870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTH07_03875	COG0735	belongs to the Fur family
GTH07_03885	COG0583	DNA-binding transcription factor activity
GTH07_03895	COG1346	cytolysis
GTH07_03910	COG0596	Alpha beta hydrolase
GTH07_03915	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GTH07_03920	COG0033	Phosphoglucomutase
GTH07_03930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GTH07_03935	COG0372	Belongs to the citrate synthase family
GTH07_03940	COG2009	succinate dehydrogenase
GTH07_03945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GTH07_03950	COG1053	succinate dehydrogenase
GTH07_03960	COG0567	Dehydrogenase, E1 component
GTH07_03965	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTH07_03970	COG0045	succinate-CoA ligase (ADP-forming) activity
GTH07_03980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTH07_03985	COG1121	(ABC) transporter
GTH07_03990	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GTH07_03995	COG4977	sequence-specific DNA binding
GTH07_04000	COG1918	ferrous iron import across plasma membrane
GTH07_04020	COG0018	arginyl-trna synthetase
GTH07_04030	COG1025	Belongs to the peptidase M16 family
GTH07_04035	COG2062	phosphohistidine phosphatase, SixA
GTH07_04065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GTH07_04070	COG0643	Histidine kinase
GTH07_04070	COG0784	Response regulator, receiver
GTH07_04070	COG2198	Histidine kinase
GTH07_04075	COG2201	protein-glutamate methylesterase activity
GTH07_04080	COG1192	Involved in chromosome partitioning
GTH07_04090	COG0835	chemotaxis
GTH07_04100	COG4133	protoheme IX ABC transporter activity
GTH07_04105	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTH07_04110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTH07_04120	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GTH07_04125	COG1138	Cytochrome C-type biogenesis protein
GTH07_04130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTH07_04135	COG4235	cytochrome complex assembly
GTH07_04135	COG3088	subunit of a heme lyase
GTH07_04145	COG2853	Lipoprotein
GTH07_04165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GTH07_04170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTH07_04175	COG0123	including yeast histone deacetylase and acetoin utilization protein
GTH07_04190	COG3083	sulfuric ester hydrolase activity
GTH07_04195	COG3082	Protein of unknown function (DUF1414)
GTH07_04200	COG3081	Nucleoid-associated protein
GTH07_04210	COG1757	Na H antiporter
GTH07_04215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTH07_04220	COG2095	MarC family integral membrane protein
GTH07_04225	COG1454	alcohol dehydrogenase
GTH07_04225	COG1012	belongs to the aldehyde dehydrogenase family
GTH07_04235	COG0659	secondary active sulfate transmembrane transporter activity
GTH07_04240	COG1530	ribonuclease E activity
GTH07_04245	COG0564	pseudouridine synthase activity
GTH07_04250	COG0424	maF-like protein
GTH07_04255	COG1399	metal-binding, possibly nucleic acid-binding protein
GTH07_04260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GTH07_04265	COG0416	fatty acid biosynthetic process
GTH07_04270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTH07_04280	COG1028	Short-chain dehydrogenase reductase Sdr
GTH07_04285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTH07_04290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTH07_04295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTH07_04300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GTH07_04305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GTH07_04315	COG0084	hydrolase, TatD family'
GTH07_04320	COG1263	PTS System
GTH07_04320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH07_04330	COG0733	neurotransmitter:sodium symporter activity
GTH07_04345	COG4667	esterase of the alpha-beta hydrolase superfamily
GTH07_04355	COG1940	carbohydrate kinase activity
GTH07_04360	COG0835	chemotaxis
GTH07_04360	COG0784	Response regulator, receiver
GTH07_04375	COG2226	methyltransferase
GTH07_04385	COG0676	glucose-6-phosphate 1-epimerase activity
GTH07_04390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTH07_04395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTH07_04405	COG3139	Protein of unknown function (DUF1315)
GTH07_04410	COG0252	asparaginase activity
GTH07_04415	COG0616	signal peptide processing
GTH07_04420	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTH07_04420	COG1902	pentaerythritol trinitrate reductase activity
GTH07_04425	COG0788	formyltetrahydrofolate deformylase activity
GTH07_04435	COG1199	ATP-dependent helicase activity
GTH07_04440	COG1214	PFAM Peptidase M22, glycoprotease
GTH07_04455	COG0596	Alpha beta hydrolase
GTH07_04460	COG0318	PFAM AMP-dependent synthetase and ligase
GTH07_04465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GTH07_04485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GTH07_04490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GTH07_04495	COG0436	Aminotransferase
GTH07_04500	COG1169	isochorismate synthase
GTH07_04505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GTH07_04510	COG0596	Alpha beta hydrolase
GTH07_04530	COG3135	benzoate transporter
GTH07_04535	COG1396	sequence-specific DNA binding
GTH07_04540	COG0840	transmembrane signaling receptor activity
GTH07_04550	COG0477	Major facilitator Superfamily
GTH07_04570	COG3015	lipoprotein NlpE involved in copper resistance
GTH07_04575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GTH07_04585	COG0850	regulation of cytokinetic process
GTH07_04590	COG3100	YcgL domain-containing protein
GTH07_04595	COG2951	lytic endotransglycosylase activity
GTH07_04605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTH07_04610	COG3469	chitinase activity
GTH07_04610	COG3325	Belongs to the glycosyl hydrolase 18 family
GTH07_04615	COG3005	denitrification pathway
GTH07_04620	COG0243	molybdopterin cofactor binding
GTH07_04635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTH07_04645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GTH07_04680	COG4589	Belongs to the CDS family
GTH07_04690	COG5001	Diguanylate cyclase
GTH07_04690	COG3300	MHYT domain
GTH07_04700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GTH07_04705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTH07_04710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GTH07_04715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GTH07_04725	COG4191	Histidine kinase
GTH07_04735	COG0544	peptidyl-prolyl cis-trans isomerase activity
GTH07_04745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GTH07_04750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GTH07_04755	COG0776	regulation of translation
GTH07_04760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTH07_04765	COG1555	photosystem II stabilization
GTH07_04770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GTH07_04775	COG0539	negative regulation of cytoplasmic translation
GTH07_04780	COG0776	regulation of translation
GTH07_04785	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GTH07_04790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GTH07_04810	COG0583	DNA-binding transcription factor activity
GTH07_04820	COG0686	Belongs to the AlaDH PNT family
GTH07_04830	COG1674	ftsk spoiiie
GTH07_04835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GTH07_04840	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GTH07_04845	COG2186	Transcriptional regulator
GTH07_04860	COG0537	adenosine 5'-monophosphoramidase activity
GTH07_04885	COG3150	esterase
GTH07_04890	COG1252	NADH dehydrogenase
GTH07_04910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTH07_04920	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTH07_04925	COG1136	(ABC) transporter
GTH07_04930	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTH07_04940	COG2333	competence protein COMEC
GTH07_04940	COG0658	competence protein
GTH07_04945	COG1132	(ABC) transporter
GTH07_04950	COG1663	tetraacyldisaccharide 4'-kinase activity
GTH07_04955	COG2835	tetraacyldisaccharide 4'-kinase activity
GTH07_04960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GTH07_04965	COG2719	SpoVR family
GTH07_04970	COG2718	Belongs to the UPF0229 family
GTH07_04975	COG2766	serine protein kinase
GTH07_04980	COG3013	Belongs to the UPF0304 family
GTH07_04990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GTH07_04995	COG0840	transmembrane signaling receptor activity
GTH07_05005	COG1882	Formate acetyltransferase
GTH07_05030	COG4160	amino acid transport
GTH07_05035	COG0708	Exodeoxyribonuclease III
GTH07_05040	COG0840	transmembrane signaling receptor activity
GTH07_05050	COG3923	Primosomal replication protein n
GTH07_05055	COG0730	response to heat
GTH07_05060	COG1199	ATP-dependent helicase activity
GTH07_05065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTH07_05070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GTH07_05075	COG3012	SEC-C Motif Domain Protein
GTH07_05080	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTH07_05085	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTH07_05090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTH07_05095	COG0215	cysteine-tRNA ligase activity
GTH07_05100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GTH07_05105	COG0632	four-way junction helicase activity
GTH07_05115	COG1271	oxidase subunit
GTH07_05120	COG1294	oxidase, subunit
GTH07_05125	COG4890	Cyd operon protein YbgT
GTH07_05130	COG3790	cyd operon protein YbgE
GTH07_05135	COG0824	Thioesterase
GTH07_05140	COG0811	peptide transport
GTH07_05155	COG0823	Involved in the tonB-independent uptake of proteins
GTH07_05160	COG2885	chlorophyll binding
GTH07_05170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GTH07_05180	COG0784	Response regulator, receiver
GTH07_05180	COG5002	protein histidine kinase activity
GTH07_05190	COG1482	cell wall glycoprotein biosynthetic process
GTH07_05195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH07_05195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH07_05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH07_05200	COG2207	Transcriptional regulator
GTH07_05210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH07_05215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH07_05220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH07_05230	COG1012	belongs to the aldehyde dehydrogenase family
GTH07_05235	COG3284	Transcriptional regulator
GTH07_05240	COG4628	conserved protein (DUF2132)
GTH07_05250	COG0415	Belongs to the DNA photolyase family
GTH07_05330	COG0488	(ABC) transporter
GTH07_05370	COG3941	tape measure
GTH07_05390	COG2003	Belongs to the UPF0758 family
GTH07_05400	COG4409	exo-alpha-(2->6)-sialidase activity
GTH07_05405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTH07_05410	COG1940	carbohydrate kinase activity
GTH07_05420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTH07_05425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GTH07_05430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GTH07_05435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTH07_05440	COG1737	Transcriptional regulator
GTH07_05445	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GTH07_05450	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GTH07_05470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GTH07_05490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GTH07_05510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTH07_05515	COG0582	viral genome integration into host DNA
GTH07_05520	COG0582	viral genome integration into host DNA
GTH07_05535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH07_05545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTH07_05545	COG3008	intermembrane lipid transfer
GTH07_05550	COG2995	paraquat-inducible protein a
GTH07_05555	COG0668	transmembrane transport
GTH07_05575	COG1309	transcriptional regulator
GTH07_05580	COG1012	belongs to the aldehyde dehydrogenase family
GTH07_05600	COG1960	acyl-CoA dehydrogenase activity
GTH07_05605	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTH07_05610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GTH07_05615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GTH07_05620	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GTH07_05625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GTH07_05635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTH07_05640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTH07_05645	COG0297	glycogen (starch) synthase activity
GTH07_05665	COG3070	regulator of competence-specific genes
GTH07_05670	COG1609	Transcriptional regulator
GTH07_05675	COG3381	protein complex oligomerization
GTH07_05680	COG0745	RESPONSE REGULATOR receiver
GTH07_05685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTH07_05690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTH07_05695	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GTH07_05700	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GTH07_05705	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GTH07_05720	COG1032	radical SAM domain protein
GTH07_05725	COG5001	Diguanylate cyclase
GTH07_05730	COG0612	Peptidase, M16
GTH07_05745	COG0583	DNA-binding transcription factor activity
GTH07_05750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTH07_05760	COG2350	Protein conserved in bacteria
GTH07_05765	COG1607	acyl-coa hydrolase
GTH07_05780	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTH07_05785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTH07_05795	COG2116	formate transmembrane transporter activity
GTH07_05800	COG4459	periplasmic nitrate reductase
GTH07_05805	COG3005	denitrification pathway
GTH07_05810	COG0243	molybdopterin cofactor binding
GTH07_05830	COG1227	inorganic diphosphatase activity
GTH07_05845	COG4172	Belongs to the ABC transporter superfamily
GTH07_05860	COG4168	peptide transport system, permease
GTH07_05865	COG0747	negative chemotaxis
GTH07_05870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTH07_05875	COG1842	Phage shock protein A
GTH07_05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH07_05905	COG2818	Glycosylase
GTH07_05910	COG0626	cystathionine gamma-synthase activity
GTH07_05920	COG0733	neurotransmitter:sodium symporter activity
GTH07_05925	COG0564	pseudouridine synthase activity
GTH07_05930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTH07_05935	COG4136	ATPase activity
GTH07_05940	COG4135	transport system, permease component
GTH07_05945	COG4134	Bacterial extracellular solute-binding protein
GTH07_05955	COG3313	Fe-S protein
GTH07_05965	COG0842	Transport permease protein
GTH07_05970	COG1131	(ABC) transporter
GTH07_05975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH07_05980	COG0814	amino acid
GTH07_05990	COG2239	Acts as a magnesium transporter
GTH07_05995	COG0784	Response regulator, receiver
GTH07_05995	COG2205	protein histidine kinase activity
GTH07_06010	COG4934	collagen metabolic process
GTH07_06040	COG0840	transmembrane signaling receptor activity
GTH07_06050	COG4251	negative regulation of phosphorylation
GTH07_06050	COG3706	GGDEF domain
GTH07_06050	COG5001	Diguanylate cyclase
GTH07_06050	COG2203	Gaf domain
GTH07_06055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GTH07_06075	COG1061	Type III restriction enzyme res subunit
GTH07_06080	COG1187	pseudouridine synthase activity
GTH07_06085	COG2814	Major facilitator Superfamily
GTH07_06095	COG0702	epimerase
GTH07_06100	COG0534	Mate efflux family protein
GTH07_06105	COG4181	ATPase activity
GTH07_06110	COG0577	efflux transmembrane transporter activity
GTH07_06120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GTH07_06130	COG1748	Saccharopine dehydrogenase
GTH07_06145	COG1538	Outer membrane efflux protein
GTH07_06185	COG0583	DNA-binding transcription factor activity
GTH07_06195	COG1451	nucleotide metabolic process
GTH07_06210	COG3063	Type IV pilus biogenesis stability protein PilW
GTH07_06215	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GTH07_06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH07_06250	COG3290	protein histidine kinase activity
GTH07_06255	COG4565	transcriptional regulatory protein
GTH07_06265	COG0784	Response regulator, receiver
GTH07_06265	COG0835	chemotaxis
GTH07_06310	COG1085	galactose-1-phosphate uridylyltransferase
GTH07_06315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GTH07_06320	COG2017	converts alpha-aldose to the beta-anomer
GTH07_06330	COG2199	diguanylate cyclase activity
GTH07_06330	COG2200	EAL domain
GTH07_06345	COG3527	Alpha-acetolactate decarboxylase
GTH07_06360	COG0753	catalase activity
GTH07_06380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTH07_06390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTH07_06405	COG3097	Belongs to the UPF0267 family
GTH07_06430	COG1271	oxidase subunit
GTH07_06435	COG1294	oxidase, subunit
GTH07_06440	COG1136	(ABC) transporter
GTH07_06440	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTH07_06445	COG1136	(ABC) transporter
GTH07_06445	COG0577	efflux transmembrane transporter activity
GTH07_06450	COG1136	(ABC) transporter
GTH07_06450	COG0577	efflux transmembrane transporter activity
GTH07_06470	COG0583	DNA-binding transcription factor activity
GTH07_06480	COG2723	6-phospho-beta-galactosidase activity
GTH07_06485	COG1609	Transcriptional regulator
GTH07_06490	COG0251	oxidation-reduction process
GTH07_06495	COG2731	YhcH YjgK YiaL family protein
GTH07_06500	COG0584	glycerophosphoryl diester phosphodiesterase
GTH07_06505	COG1349	DNA-binding transcription factor activity
GTH07_06510	COG3842	ATPase activity
GTH07_06515	COG0395	ABC-type sugar transport system, permease component
GTH07_06520	COG1175	transmembrane transport
GTH07_06535	COG0811	peptide transport
GTH07_06540	COG0811	peptide transport
GTH07_06545	COG0848	biopolymer transport protein
GTH07_06550	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GTH07_06560	COG1793	dna ligase
GTH07_06570	COG0534	Mate efflux family protein
GTH07_06580	COG3001	Fructosamine kinase
GTH07_06590	COG0791	NLP P60 protein
GTH07_06595	COG0840	transmembrane signaling receptor activity
GTH07_06605	COG3148	PFAM DTW domain containing protein
GTH07_06610	COG1940	carbohydrate kinase activity
GTH07_06630	COG0746	molybdenum cofactor guanylyltransferase activity
GTH07_06635	COG3842	ATPase activity
GTH07_06640	COG4662	Binding-protein-dependent transport system inner membrane component
GTH07_06650	COG2204	response regulator
GTH07_06655	COG3852	Histidine kinase
GTH07_06660	COG0488	(ABC) transporter
GTH07_06665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GTH07_06695	COG3383	formate dehydrogenase (NAD+) activity
GTH07_06695	COG0243	molybdopterin cofactor binding
GTH07_06700	COG0437	4 iron, 4 sulfur cluster binding
GTH07_06715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTH07_06720	COG1666	GTP binding
GTH07_06725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTH07_06740	COG2996	Protein conserved in bacteria
GTH07_06750	COG3008	intermembrane lipid transfer
GTH07_06755	COG2995	paraquat-inducible protein a
GTH07_06760	COG1132	(ABC) transporter
GTH07_06765	COG1956	GAF domain-containing protein
GTH07_06770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GTH07_06785	COG0308	aminopeptidase N
GTH07_06800	COG0167	dihydroorotate dehydrogenase activity
GTH07_06810	COG0116	Belongs to the methyltransferase superfamily
GTH07_06810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTH07_06820	COG0488	(ABC) transporter
GTH07_06835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTH07_06840	COG1067	ATP-dependent peptidase activity
GTH07_06845	COG3120	sequence-specific DNA binding
GTH07_06920	COG1476	TRANSCRIPTIONal
GTH07_06985	COG1476	TRANSCRIPTIONal
GTH07_07015	COG4128	Pfam Zonular occludens toxin
GTH07_07030	COG1073	alpha beta
GTH07_07030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GTH07_07030	COG3064	Membrane
GTH07_07035	COG2994	toxin metabolic process
GTH07_07060	COG2205	protein histidine kinase activity
GTH07_07060	COG0784	Response regulator, receiver
GTH07_07075	COG3278	Belongs to the heme-copper respiratory oxidase family
GTH07_07090	COG2010	Cytochrome c
GTH07_07100	COG2217	Heavy metal translocating P-type atpase
GTH07_07115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTH07_07120	COG0589	response to stress
GTH07_07145	COG3842	ATPase activity
GTH07_07155	COG1177	transmembrane transport
GTH07_07165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTH07_07180	COG1115	amino acid carrier protein
GTH07_07185	COG1280	lysine exporter protein (LysE YggA)
GTH07_07200	COG3675	Pfam Lipase (class 3)
GTH07_07210	COG3501	Rhs element vgr protein
GTH07_07220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GTH07_07225	COG0840	transmembrane signaling receptor activity
GTH07_07230	COG2814	Major facilitator Superfamily
GTH07_07235	COG1566	PFAM secretion protein HlyD family protein
GTH07_07240	COG1538	Outer membrane efflux protein
GTH07_07250	COG0513	Belongs to the DEAD box helicase family
GTH07_07260	COG0840	transmembrane signaling receptor activity
GTH07_07265	COG0840	transmembrane signaling receptor activity
GTH07_07265	COG3290	protein histidine kinase activity
GTH07_07270	COG0835	chemotaxis
GTH07_07275	COG2201	protein-glutamate methylesterase activity
GTH07_07285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTH07_07290	COG0643	Histidine kinase
GTH07_07290	COG0784	Response regulator, receiver
GTH07_07290	COG2198	Histidine kinase
GTH07_07295	COG2198	Histidine kinase
GTH07_07295	COG0643	Histidine kinase
GTH07_07305	COG0745	RESPONSE REGULATOR receiver
GTH07_07320	COG0415	Belongs to the DNA photolyase family
GTH07_07325	COG0477	Major facilitator Superfamily
GTH07_07330	COG0583	DNA-binding transcription factor activity
GTH07_07340	COG0095	Lipoate-protein ligase
GTH07_07345	COG0443	Heat shock 70 kDa protein
GTH07_07355	COG1643	Atp-dependent helicase
GTH07_07385	COG0443	Heat shock 70 kDa protein
GTH07_07390	COG0443	Heat shock 70 kDa protein
GTH07_07395	COG3706	GGDEF domain
GTH07_07425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GTH07_07430	COG0602	queuosine metabolic process
GTH07_07435	COG0561	phosphatase activity
GTH07_07445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH07_07450	COG4597	amino acid ABC transporter
GTH07_07455	COG0765	amino acid transport
GTH07_07460	COG1126	abc transporter atp-binding protein
GTH07_07465	COG0670	Belongs to the BI1 family
GTH07_07470	COG2920	part of a sulfur-relay system
GTH07_07475	COG1254	Belongs to the acylphosphatase family
GTH07_07480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTH07_07485	COG3706	GGDEF domain
GTH07_07495	COG3437	response regulator, receiver
GTH07_07495	COG3850	Histidine kinase
GTH07_07495	COG4999	Histidine kinase
GTH07_07495	COG2205	protein histidine kinase activity
GTH07_07500	COG3437	response regulator, receiver
GTH07_07505	COG0625	glutathione transferase activity
GTH07_07515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GTH07_07525	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTH07_07555	COG0372	Belongs to the citrate synthase family
GTH07_07560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GTH07_07600	COG1129	ABC transporter
GTH07_07625	COG0745	RESPONSE REGULATOR receiver
GTH07_07630	COG2205	protein histidine kinase activity
GTH07_07635	COG3713	MltA-interacting MipA family protein
GTH07_07640	COG2990	Protein conserved in bacteria
GTH07_07650	COG4191	Histidine kinase
GTH07_07650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH07_07655	COG0471	metal ion transport
GTH07_07665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTH07_07680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH07_07690	COG3768	UPF0283 membrane protein
GTH07_07695	COG3106	COG3106 Predicted ATPase
GTH07_07710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTH07_07715	COG0494	nUDIX hydrolase
GTH07_07720	COG0814	amino acid
GTH07_07725	COG1760	l-serine dehydratase
GTH07_07730	COG0720	synthase
GTH07_07740	COG0017	Asparaginyl-tRNA synthetase
GTH07_07745	COG0351	phosphomethylpyrimidine kinase
GTH07_07745	COG0352	thiamine-phosphate diphosphorylase activity
GTH07_07750	COG3437	response regulator, receiver
GTH07_07750	COG2770	Histidine kinase
GTH07_07755	COG1448	Aminotransferase
GTH07_07770	COG0840	transmembrane signaling receptor activity
GTH07_07775	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GTH07_07780	COG2943	transferase activity, transferring hexosyl groups
GTH07_07785	COG1609	Transcriptional regulator
GTH07_07790	COG3394	polysaccharide catabolic process
GTH07_07795	COG1486	melibiose metabolic process
GTH07_07800	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTH07_07810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTH07_07815	COG0726	polysaccharide deacetylase
GTH07_07820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTH07_07825	COG1846	Transcriptional regulator
GTH07_07850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GTH07_07865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTH07_07870	COG3108	Peptidase M15
GTH07_07900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTH07_07910	COG2814	Major facilitator Superfamily
GTH07_07920	COG1054	Belongs to the UPF0176 family
GTH07_07930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTH07_07935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTH07_07940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTH07_07990	COG4139	cobalamin transport
GTH07_08010	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GTH07_08015	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GTH07_08020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTH07_08025	COG1823	symporter activity
GTH07_08030	COG2925	Exonuclease
GTH07_08035	COG1380	Effector of murein hydrolase LrgA
GTH07_08040	COG1346	cytolysis
GTH07_08045	COG0295	cytidine deaminase activity
GTH07_08060	COG0500	methyltransferase
GTH07_08070	COG0776	regulation of translation
GTH07_08075	COG0072	phenylalanine-tRNA ligase activity
GTH07_08075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTH07_08080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GTH07_08120	COG0322	excinuclease ABC activity
GTH07_08125	COG2197	response regulator
GTH07_08130	COG0417	DNA replication proofreading
GTH07_08135	COG5001	Diguanylate cyclase
GTH07_08145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTH07_08150	COG3099	Belongs to the UPF0263 family
GTH07_08165	COG1228	amidohydrolase
GTH07_08170	COG0010	Belongs to the arginase family
GTH07_08175	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GTH07_08180	COG2986	histidine ammonia-lyase
GTH07_08200	COG0247	lactate metabolic process
GTH07_08200	COG0277	FAD linked oxidase domain protein
GTH07_08215	COG2885	chlorophyll binding
GTH07_08235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GTH07_08245	COG0281	malic enzyme
GTH07_08255	COG2949	membrane
GTH07_08260	COG3706	GGDEF domain
GTH07_08275	COG0492	ferredoxin-NADP+ reductase activity
GTH07_08280	COG4988	ABC transporter
GTH07_08285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GTH07_08290	COG1187	pseudouridine synthase activity
GTH07_08295	COG0009	L-threonylcarbamoyladenylate synthase
GTH07_08300	COG0613	PHP domain protein
GTH07_08310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTH07_08315	COG0512	Glutamine amidotransferase of anthranilate synthase
GTH07_08320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GTH07_08325	COG0134	indole-3-glycerol-phosphate synthase activity
GTH07_08325	COG0135	phosphoribosylanthranilate isomerase activity
GTH07_08330	COG0133	tryptophan synthase activity
GTH07_08335	COG0159	tryptophan synthase activity
GTH07_08345	COG1435	thymidine kinase activity
GTH07_08350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GTH07_08355	COG1801	Protein of unknown function DUF72
GTH07_08360	COG4106	trans-aconitate 2-methyltransferase activity
GTH07_08365	COG0500	methyltransferase
GTH07_08370	COG4067	protein conserved in archaea
GTH07_08370	COG0189	ligase activity
GTH07_08385	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GTH07_08395	COG3852	Histidine kinase
GTH07_08410	COG3070	regulator of competence-specific genes
GTH07_08420	COG2431	L-lysine efflux transmembrane transporter activity
GTH07_08430	COG0076	glutamate decarboxylase activity
GTH07_08435	COG1737	Transcriptional regulator
GTH07_08440	COG1454	alcohol dehydrogenase
GTH07_08440	COG1012	belongs to the aldehyde dehydrogenase family
GTH07_08445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTH07_08450	COG3273	potassium ion transport
GTH07_08450	COG2985	domain, Protein
GTH07_08455	COG0542	response to heat
GTH07_08460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GTH07_08465	COG1278	Cold shock
GTH07_08475	COG1187	pseudouridine synthase activity
GTH07_08480	COG0140	phosphoribosyl-ATP diphosphatase activity
GTH07_08480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GTH07_08485	COG0107	imidazoleglycerol-phosphate synthase activity
GTH07_08490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GTH07_08495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GTH07_08500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GTH07_08500	COG0131	Imidazoleglycerol-phosphate dehydratase
GTH07_08505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GTH07_08510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GTH07_08515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GTH07_08520	COG1757	Na H antiporter
GTH07_08525	COG2916	Histone family protein nucleoid-structuring protein H-NS
GTH07_08530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH07_08535	COG0482	sulfurtransferase activity
GTH07_08540	COG2915	High frequency lysogenization protein hflD homolog
GTH07_08545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTH07_08555	COG2268	Band 7 protein
GTH07_08565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTH07_08580	COG0300	oxidoreductase activity
GTH07_08590	COG0501	Belongs to the peptidase M48B family
GTH07_08600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GTH07_08605	COG2226	methyltransferase
GTH07_08610	COG0156	8-amino-7-oxononanoate synthase activity
GTH07_08615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTH07_08620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTH07_08625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GTH07_08630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTH07_08635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GTH07_08640	COG0653	protein targeting
GTH07_08645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTH07_08650	COG2199	diguanylate cyclase activity
GTH07_08650	COG2203	Gaf domain
GTH07_08660	COG4120	Belongs to the binding-protein-dependent transport system permease family
GTH07_08670	COG4628	conserved protein (DUF2132)
GTH07_08675	COG3092	negative regulation of chromosome organization
GTH07_08680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTH07_08685	COG0857	belongs to the CobB CobQ family
GTH07_08685	COG0280	phosphate acetyltransferase
GTH07_08690	COG0435	Glutathione S-transferase
GTH07_08695	COG4608	Belongs to the ABC transporter superfamily
GTH07_08700	COG0444	Belongs to the ABC transporter superfamily
GTH07_08705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH07_08710	COG0601	transmembrane transport
GTH07_08730	COG2204	response regulator
GTH07_08735	COG3300	MHYT domain
GTH07_08735	COG5001	Diguanylate cyclase
GTH07_08740	COG4191	Histidine kinase
GTH07_08745	COG5002	protein histidine kinase activity
GTH07_08755	COG2201	protein-glutamate methylesterase activity
GTH07_08770	COG0009	L-threonylcarbamoyladenylate synthase
GTH07_08785	COG1881	PFAM PEBP family protein
GTH07_08810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTH07_08815	COG0640	Transcriptional regulator
GTH07_08825	COG3706	GGDEF domain
GTH07_08845	COG1946	Acyl-CoA thioesterase
GTH07_08850	COG1522	sequence-specific DNA binding
GTH07_08860	COG0616	signal peptide processing
GTH07_08865	COG1028	Short-chain dehydrogenase reductase Sdr
GTH07_08870	COG2983	Belongs to the UPF0260 family
GTH07_08880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GTH07_08885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GTH07_08895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTH07_08900	COG2832	Protein of unknown function (DUF454)
GTH07_08905	COG0745	RESPONSE REGULATOR receiver
GTH07_08910	COG0583	DNA-binding transcription factor activity
GTH07_08915	COG0778	Nitroreductase
GTH07_08920	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTH07_08920	COG1024	Enoyl-CoA hydratase
GTH07_08925	COG0183	Belongs to the thiolase family
GTH07_08940	COG2067	long-chain fatty acid transport protein
GTH07_08950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTH07_08955	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GTH07_08960	COG2982	Protein involved in outer membrane biogenesis
GTH07_08965	COG0572	uridine kinase
GTH07_08970	COG0489	protein tyrosine kinase activity
GTH07_08975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTH07_08975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTH07_08985	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GTH07_08995	COG0517	IMP dehydrogenase activity
GTH07_08995	COG0617	tRNA 3'-terminal CCA addition
GTH07_08995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GTH07_09000	COG2199	diguanylate cyclase activity
GTH07_09005	COG0314	molybdopterin synthase activity
GTH07_09010	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GTH07_09015	COG0315	cyclic pyranopterin monophosphate synthase activity
GTH07_09020	COG0521	Mo-molybdopterin cofactor biosynthetic process
GTH07_09025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GTH07_09030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GTH07_09035	COG2198	Histidine kinase
GTH07_09040	COG2204	response regulator
GTH07_09045	COG0556	nucleotide-excision repair
GTH07_09055	COG4657	Part of a membrane complex involved in electron transport
GTH07_09060	COG2878	Part of a membrane complex involved in electron transport
GTH07_09065	COG4656	Part of a membrane complex involved in electron transport
GTH07_09070	COG4658	electron transport chain
GTH07_09075	COG4659	FMN binding
GTH07_09080	COG4660	Part of a membrane complex involved in electron transport
GTH07_09085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTH07_09090	COG0346	lactoylglutathione lyase activity
GTH07_09105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTH07_09110	COG2056	Na+-H+ antiporter family
GTH07_09115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GTH07_09120	COG1286	toxin biosynthetic process
GTH07_09125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GTH07_09130	COG0285	dihydrofolate synthase activity
GTH07_09135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GTH07_09140	COG0101	tRNA pseudouridine synthase activity
GTH07_09155	COG1263	PTS System
GTH07_09155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH07_09155	COG2190	(PTS) system
GTH07_09160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTH07_09165	COG1846	Transcriptional regulator
GTH07_09165	COG1940	carbohydrate kinase activity
GTH07_09170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTH07_09170	COG4651	solute:proton antiporter activity
GTH07_09175	COG0367	asparagine synthase
GTH07_09190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GTH07_09195	COG0563	adenylate kinase activity
GTH07_09200	COG0326	Molecular chaperone. Has ATPase activity
GTH07_09205	COG3710	Transcriptional regulator
GTH07_09220	COG0622	Phosphoesterase
GTH07_09225	COG1090	epimerase
GTH07_09230	COG0300	oxidoreductase activity
GTH07_09235	COG3118	belongs to the thioredoxin family
GTH07_09240	COG0330	HflC and HflK could
GTH07_09245	COG1585	Membrane protein implicated in regulation of membrane protease activity
GTH07_09250	COG0789	Transcriptional regulator
GTH07_09265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GTH07_09270	COG3115	cell septum assembly
GTH07_09275	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GTH07_09280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTH07_09285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH07_09295	COG2190	(PTS) system
GTH07_09300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTH07_09305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTH07_09310	COG1702	phosphate starvation-inducible protein PhoH
GTH07_09315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GTH07_09320	COG4535	Mg2 and Co2 transporter CorC
GTH07_09325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GTH07_09330	COG2888	peptidyl-tyrosine sulfation
GTH07_09335	COG0495	leucyl-tRNA aminoacylation
GTH07_09340	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GTH07_09345	COG1466	dna polymerase III delta subunit
GTH07_09350	COG0799	negative regulation of ribosome biogenesis
GTH07_09355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GTH07_09360	COG0768	penicillin binding
GTH07_09365	COG0772	Belongs to the SEDS family
GTH07_09370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTH07_09375	COG1686	Belongs to the peptidase S11 family
GTH07_09380	COG2921	Belongs to the UPF0250 family
GTH07_09385	COG0321	lipoyl(octanoyl) transferase activity
GTH07_09390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GTH07_09400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTH07_09425	COG1596	polysaccharide export
GTH07_09435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTH07_09465	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GTH07_09475	COG0438	transferase activity, transferring glycosyl groups
GTH07_09485	COG1045	serine acetyltransferase
GTH07_09505	COG0110	maltose O-acetyltransferase activity
GTH07_09510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GTH07_09515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTH07_09520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTH07_09525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH07_09555	COG0366	Alpha amylase catalytic
GTH07_09560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH07_09560	COG1263	PTS System
GTH07_09565	COG1609	Transcriptional regulator
GTH07_09570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GTH07_09575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTH07_09580	COG2011	ABC-type metal ion transport system permease component
GTH07_09585	COG1464	Belongs to the NlpA lipoprotein family
GTH07_09590	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GTH07_09600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTH07_09600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTH07_09615	COG1611	Belongs to the LOG family
GTH07_09620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTH07_09625	COG2363	Small membrane protein
GTH07_09630	COG0583	DNA-binding transcription factor activity
GTH07_09635	COG0301	tRNA thio-modification
GTH07_09635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTH07_09645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GTH07_09650	COG1722	exodeoxyribonuclease VII activity
GTH07_09655	COG0142	geranyltranstransferase activity
GTH07_09660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GTH07_09665	COG0564	pseudouridine synthase activity
GTH07_09670	COG3098	single-species biofilm formation
GTH07_09685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH07_09695	COG1671	Belongs to the UPF0178 family
GTH07_09700	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GTH07_09705	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTH07_09710	COG0254	rRNA binding
GTH07_09715	COG1720	tRNA m6t6A37 methyltransferase activity
GTH07_09720	COG0442	prolyl-tRNA aminoacylation
GTH07_09745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTH07_09745	COG0047	phosphoribosylformylglycinamidine synthase activity
GTH07_09755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GTH07_09765	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GTH07_09795	COG0484	heat shock protein binding
GTH07_09800	COG0443	Heat shock 70 kDa protein
GTH07_09805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GTH07_09810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTH07_09815	COG0497	DNA recombination
GTH07_09820	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTH07_09825	COG2914	Belongs to the UPF0125 (RnfH) family
GTH07_09830	COG2867	negative regulation of translational initiation
GTH07_09835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GTH07_09845	COG0582	viral genome integration into host DNA
GTH07_09855	COG0582	viral genome integration into host DNA
GTH07_09860	COG3064	Membrane
GTH07_09870	COG0739	heme binding
GTH07_09890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GTH07_09895	COG2207	Transcriptional regulator
GTH07_09905	COG1459	type II secretion system
GTH07_09910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTH07_09930	COG4796	Type ii and iii secretion system protein
GTH07_09955	COG3710	Transcriptional regulator
GTH07_09960	COG0840	transmembrane signaling receptor activity
GTH07_09965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTH07_09985	COG1012	belongs to the aldehyde dehydrogenase family
GTH07_10040	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GTH07_10045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GTH07_10050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTH07_10070	COG3051	citrate lyase alpha subunit
GTH07_10075	COG2301	Belongs to the HpcH HpaI aldolase family
GTH07_10080	COG3052	prosthetic group binding
GTH07_10085	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GTH07_10095	COG3630	sodium ion export across plasma membrane
GTH07_10100	COG0511	ligase activity, forming carbon-carbon bonds
GTH07_10100	COG5016	pyruvate
GTH07_10105	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GTH07_10115	COG4565	transcriptional regulatory protein
GTH07_10130	COG0583	DNA-binding transcription factor activity
GTH07_10140	COG1115	amino acid carrier protein
GTH07_10145	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GTH07_10150	COG0583	DNA-binding transcription factor activity
GTH07_10160	COG1120	ATPase activity
GTH07_10165	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH07_10170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH07_10175	COG4592	Periplasmic binding protein
GTH07_10185	COG1028	Short-chain dehydrogenase reductase Sdr
GTH07_10190	COG1169	isochorismate synthase
GTH07_10195	COG1021	2,3-dihydroxybenzoate-AMP ligase
GTH07_10200	COG1535	isochorismatase
GTH07_10200	COG3433	isochorismatase activity
GTH07_10205	COG1584	GPR1 FUN34 yaaH family protein
GTH07_10215	COG0519	Catalyzes the synthesis of GMP from XMP
GTH07_10215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GTH07_10220	COG0516	GMP reductase activity
GTH07_10220	COG0517	IMP dehydrogenase activity
GTH07_10225	COG1570	exodeoxyribonuclease VII activity
GTH07_10240	COG1160	GTP binding
GTH07_10245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTH07_10250	COG2976	Protein conserved in bacteria
GTH07_10255	COG0124	histidyl-tRNA synthetase
GTH07_10260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GTH07_10275	COG0105	UTP biosynthetic process
GTH07_10280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTH07_10285	COG2975	iron-sulfur cluster assembly
GTH07_10290	COG0633	Ferredoxin
GTH07_10295	COG0443	Heat shock 70 kDa protein
GTH07_10300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GTH07_10310	COG0822	iron-sulfur transferase activity
GTH07_10315	COG1104	cysteine desulfurase activity
GTH07_10320	COG1959	2 iron, 2 sulfur cluster binding
GTH07_10330	COG0483	inositol monophosphate 1-phosphatase activity
GTH07_10335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTH07_10340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTH07_10345	COG1862	Preprotein translocase
GTH07_10350	COG0343	queuine tRNA-ribosyltransferase activity
GTH07_10355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GTH07_10360	COG0517	IMP dehydrogenase activity
GTH07_10370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GTH07_10375	COG0583	DNA-binding transcription factor activity
GTH07_10380	COG0450	alkyl hydroperoxide reductase
GTH07_10385	COG3142	Participates in the control of copper homeostasis
GTH07_10400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTH07_10405	COG0581	inorganic phosphate transmembrane transporter activity
GTH07_10415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GTH07_10420	COG0248	Ppx GppA phosphatase
GTH07_10430	COG5002	protein histidine kinase activity
GTH07_10435	COG0745	RESPONSE REGULATOR receiver
GTH07_10445	COG0826	peptidase U32
GTH07_10450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTH07_10490	COG0542	response to heat
GTH07_10495	COG1496	oxidoreductase activity
GTH07_10500	COG0564	pseudouridine synthase activity
GTH07_10505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTH07_10510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTH07_10515	COG0077	Prephenate dehydratase
GTH07_10515	COG1605	Chorismate mutase
GTH07_10520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTH07_10525	COG5001	Diguanylate cyclase
GTH07_10535	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GTH07_10545	COG0488	(ABC) transporter
GTH07_10555	COG0287	Prephenate dehydrogenase
GTH07_10555	COG1605	Chorismate mutase
GTH07_10560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTH07_10565	COG3275	phosphorelay sensor kinase activity
GTH07_10570	COG3279	Response regulator of the LytR AlgR family
GTH07_10575	COG1472	Belongs to the glycosyl hydrolase 3 family
GTH07_10580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GTH07_10585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTH07_10600	COG1966	Carbon starvation protein
GTH07_10605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GTH07_10610	COG1047	Peptidyl-prolyl cis-trans
GTH07_10615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GTH07_10620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GTH07_10625	COG0196	riboflavin kinase activity
GTH07_10630	COG0728	peptidoglycan biosynthetic process
GTH07_10635	COG0268	Binds directly to 16S ribosomal RNA
GTH07_10640	COG0640	Transcriptional regulator
GTH07_10645	COG0583	DNA-binding transcription factor activity
GTH07_10650	COG1283	sodium-dependent phosphate transmembrane transporter activity
GTH07_10655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GTH07_10660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GTH07_10665	COG0730	response to heat
GTH07_10670	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GTH07_10675	COG0494	nUDIX hydrolase
GTH07_10680	COG3066	DNA modification
GTH07_10685	COG0667	Aldo Keto reductase
GTH07_10695	COG2204	response regulator
GTH07_10700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GTH07_10720	COG0513	Belongs to the DEAD box helicase family
GTH07_10725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GTH07_10745	COG3153	acetyltransferase
GTH07_10750	COG3154	lipid carrier protein
GTH07_10760	COG0826	peptidase U32
GTH07_10765	COG0826	peptidase U32
GTH07_10785	COG1185	polyribonucleotide nucleotidyltransferase activity
GTH07_10790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GTH07_10800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GTH07_10805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GTH07_10810	COG0195	Participates in both transcription termination and antitermination
GTH07_10815	COG0779	Required for maturation of 30S ribosomal subunits
GTH07_10830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTH07_10840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GTH07_10845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GTH07_10850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GTH07_10855	COG1534	Rna-binding protein
GTH07_10860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTH07_10865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTH07_10870	COG2027	D-alanyl-D-alanine carboxypeptidase
GTH07_10875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTH07_10880	COG0739	heme binding
GTH07_10895	COG0316	Belongs to the HesB IscA family
GTH07_10900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTH07_10910	COG0628	permease
GTH07_10915	COG2813	Specifically methylates the guanine in position
GTH07_10920	COG0784	Response regulator, receiver
GTH07_10920	COG2205	protein histidine kinase activity
GTH07_10925	COG0747	negative chemotaxis
GTH07_10930	COG0601	transmembrane transport
GTH07_10935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH07_10940	COG0444	Belongs to the ABC transporter superfamily
GTH07_10945	COG4608	Belongs to the ABC transporter superfamily
GTH07_10955	COG2971	BadF BadG BcrA BcrD
GTH07_10975	COG3842	ATPase activity
GTH07_10985	COG1840	ABC-type Fe3 transport system, periplasmic component
GTH07_10990	COG0004	ammonium transporteR
GTH07_10995	COG0347	Belongs to the P(II) protein family
GTH07_11000	COG3112	Uncharacterised protein family (UPF0231)
GTH07_11005	COG1049	propionate catabolic process, 2-methylcitrate cycle
GTH07_11010	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTH07_11015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTH07_11020	COG1643	Atp-dependent helicase
GTH07_11030	COG1489	DNA binding
GTH07_11040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTH07_11050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTH07_11055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GTH07_11060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GTH07_11065	COG0842	Transport permease protein
GTH07_11070	COG1131	(ABC) transporter
GTH07_11075	COG0659	secondary active sulfate transmembrane transporter activity
GTH07_11080	COG0288	reversible hydration of carbon dioxide
GTH07_11095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GTH07_11100	COG3107	peptidoglycan biosynthetic process
GTH07_11105	COG0792	nuclease activity
GTH07_11110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GTH07_11115	COG2823	Periplasmic or secreted lipoprotein
GTH07_11120	COG2969	positive regulation of protein catabolic process
GTH07_11125	COG0625	glutathione transferase activity
GTH07_11130	COG2857	Cytochrome c1
GTH07_11135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GTH07_11140	COG0723	plastoquinol--plastocyanin reductase activity
GTH07_11145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GTH07_11150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GTH07_11155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GTH07_11165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTH07_11170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTH07_11175	COG0335	large ribosomal subunit rRNA binding
GTH07_11180	COG0336	Belongs to the RNA methyltransferase TrmD family
GTH07_11185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GTH07_11190	COG0228	four-way junction DNA binding
GTH07_11195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTH07_11200	COG4137	Cytochrome C assembly protein
GTH07_11205	COG4536	flavin adenine dinucleotide binding
GTH07_11210	COG1854	S-ribosylhomocysteine lyase activity
GTH07_11215	COG2918	glutathione biosynthetic process
GTH07_11220	COG0612	Peptidase, M16
GTH07_11225	COG1238	metal cluster binding
GTH07_11235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GTH07_11240	COG0511	ligase activity, forming carbon-carbon bonds
GTH07_11240	COG5016	pyruvate
GTH07_11245	COG3630	sodium ion export across plasma membrane
GTH07_11295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GTH07_11300	COG0527	aspartate kinase activity
GTH07_11305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTH07_11315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GTH07_11325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GTH07_11330	COG4208	sulfate ABC transporter
GTH07_11350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GTH07_11355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTH07_11365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GTH07_11370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GTH07_11375	COG0585	pseudouridine synthase activity
GTH07_11380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GTH07_11385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GTH07_11390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GTH07_11395	COG1968	undecaprenyl-diphosphatase activity
GTH07_11400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTH07_11405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTH07_11410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTH07_11420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GTH07_11425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTH07_11430	COG1610	YqeY-like protein
GTH07_11435	COG0358	DNA primase activity
GTH07_11455	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GTH07_11460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTH07_11465	COG1349	DNA-binding transcription factor activity
GTH07_11480	COG0583	DNA-binding transcription factor activity
GTH07_11485	COG1279	arginine transmembrane transporter activity
GTH07_11490	COG0668	transmembrane transport
GTH07_11495	COG0191	fructose-bisphosphate aldolase activity
GTH07_11500	COG0126	phosphoglycerate kinase activity
GTH07_11505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTH07_11510	COG4771	TonB-dependent receptor
GTH07_11515	COG0583	DNA-binding transcription factor activity
GTH07_11520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTH07_11525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GTH07_11530	COG3091	SprT-like family
GTH07_11535	COG2356	endonuclease I
GTH07_11540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GTH07_11545	COG0189	ligase activity
GTH07_11550	COG1678	Uncharacterized ACR, COG1678
GTH07_11555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GTH07_11560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTH07_11580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GTH07_11585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTH07_11590	COG0762	integral membrane protein
GTH07_11605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTH07_11610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTH07_11615	COG2066	Belongs to the glutaminase family
GTH07_11625	COG1194	a g-specific adenine glycosylase
GTH07_11630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GTH07_11635	COG0741	lytic transglycosylase activity
GTH07_11690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GTH07_11695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GTH07_11700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTH07_11705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GTH07_11710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GTH07_11715	COG2967	ApaG domain
GTH07_11720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GTH07_11730	COG3610	response to peptide
GTH07_11735	COG2966	Psort location CytoplasmicMembrane, score
GTH07_11740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GTH07_11745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GTH07_11750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GTH07_11755	COG0142	geranyltranstransferase activity
GTH07_11760	COG0531	amino acid
GTH07_11765	COG0039	L-malate dehydrogenase activity
GTH07_11770	COG1438	arginine binding
GTH07_11775	COG2358	TRAP transporter, solute receptor (TAXI family
GTH07_11785	COG0589	response to stress
GTH07_11805	COG2235	arginine
GTH07_11810	COG0312	modulator of DNA gyrase
GTH07_11815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTH07_11820	COG3164	Protein of unknown function
GTH07_11830	COG0424	maF-like protein
GTH07_11835	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GTH07_11840	COG1792	Involved in formation and maintenance of cell shape
GTH07_11845	COG1077	Cell shape determining protein MreB Mrl
GTH07_11875	COG2165	general secretion pathway protein
GTH07_11880	COG2165	general secretion pathway protein
GTH07_11890	COG1459	type II secretion system
GTH07_11895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTH07_11905	COG3267	Type II secretory pathway component ExeA
GTH07_11905	COG3409	Peptidoglycan-binding domain 1 protein
GTH07_11930	COG2199	diguanylate cyclase activity
GTH07_11930	COG2200	EAL domain
GTH07_11935	COG0629	single-stranded DNA binding
GTH07_11950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTH07_11960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTH07_11965	COG0527	aspartate kinase activity
GTH07_11970	COG1410	methionine synthase
GTH07_11970	COG0646	methionine synthase
GTH07_12040	COG0175	sulfate reduction
GTH07_12045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GTH07_12050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTH07_12075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTH07_12080	COG0735	belongs to the Fur family
GTH07_12095	COG0166	Belongs to the GPI family
GTH07_12100	COG0432	Pfam Uncharacterised protein family UPF0047
GTH07_12105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTH07_12120	COG0359	binds to the 23S rRNA
GTH07_12125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTH07_12130	COG2965	DNA replication, synthesis of RNA primer
GTH07_12135	COG0360	Binds together with S18 to 16S ribosomal RNA
GTH07_12145	COG2906	2 iron, 2 sulfur cluster binding
GTH07_12150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTH07_12155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTH07_12160	COG0049	tRNA binding
GTH07_12175	COG2923	Belongs to the DsrF TusC family
GTH07_12180	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GTH07_12185	COG2964	Protein conserved in bacteria
GTH07_12190	COG0545	Peptidyl-prolyl cis-trans isomerase
GTH07_12200	COG2900	Belongs to the SlyX family
GTH07_12205	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GTH07_12210	COG0330	HflC and HflK could
GTH07_12215	COG0330	HflC and HflK could
GTH07_12220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTH07_12225	COG1923	regulation of RNA biosynthetic process
GTH07_12230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GTH07_12235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GTH07_12245	COG0802	atpase or kinase
GTH07_12250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GTH07_12295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GTH07_12300	COG1162	GTPase activity
GTH07_12305	COG0688	phosphatidylethanolamine metabolic process
GTH07_12310	COG0471	metal ion transport
GTH07_12320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GTH07_12325	COG4942	peptidase
GTH07_12340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GTH07_12345	COG2816	NAD+ diphosphatase activity
GTH07_12350	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GTH07_12355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GTH07_12360	COG0085	RNA polymerase activity
GTH07_12365	COG0222	ribosome binding
GTH07_12370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GTH07_12380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GTH07_12385	COG0250	Participates in transcription elongation, termination and antitermination
GTH07_12390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTH07_12395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTH07_12420	COG1072	(Pantothenic acid kinase))
GTH07_12430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTH07_12440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTH07_12485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GTH07_12500	COG3118	belongs to the thioredoxin family
GTH07_12505	COG0513	Belongs to the DEAD box helicase family
GTH07_12510	COG0248	Ppx GppA phosphatase
GTH07_12515	COG0784	Response regulator, receiver
GTH07_12515	COG2205	protein histidine kinase activity
GTH07_12520	COG2814	Major facilitator Superfamily
GTH07_12535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTH07_12540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GTH07_12545	COG0511	ligase activity, forming carbon-carbon bonds
GTH07_12550	COG0439	Biotin carboxylase
GTH07_12555	COG2264	protein methyltransferase activity
GTH07_12560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTH07_12565	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GTH07_12570	COG1609	Transcriptional regulator
GTH07_12575	COG0129	dihydroxy-acid dehydratase activity
GTH07_12580	COG3265	gluconokinase activity
GTH07_12590	COG0800	Aldolase
GTH07_12610	COG0840	transmembrane signaling receptor activity
GTH07_12615	COG1982	Orn Lys Arg decarboxylase major
GTH07_12620	COG0531	amino acid
GTH07_12625	COG3710	Transcriptional regulator
GTH07_12630	COG0789	Transcriptional regulator
GTH07_12645	COG0151	Belongs to the GarS family
GTH07_12655	COG0776	regulation of translation
GTH07_12660	COG1253	flavin adenine dinucleotide binding
GTH07_12665	COG1940	carbohydrate kinase activity
GTH07_12675	COG3068	Protein conserved in bacteria
GTH07_12685	COG1573	uracil-dna glycosylase
GTH07_12690	COG0668	transmembrane transport
GTH07_12695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GTH07_12725	COG4584	PFAM Integrase catalytic
GTH07_12755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GTH07_12755	COG2755	lipolytic protein G-D-S-L family
GTH07_12775	COG1086	Polysaccharide biosynthesis protein
GTH07_12805	COG0438	transferase activity, transferring glycosyl groups
GTH07_12810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTH07_12845	COG1519	Transferase
GTH07_12875	COG3642	lipopolysaccharide core region biosynthetic process
GTH07_12880	COG0859	PFAM glycosyl transferase family 9
GTH07_12885	COG0463	Glycosyl transferase, family 2
GTH07_12890	COG0859	PFAM glycosyl transferase family 9
GTH07_12895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GTH07_12900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GTH07_12910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTH07_12915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GTH07_12920	COG2003	Belongs to the UPF0758 family
GTH07_12930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTH07_12940	COG1309	transcriptional regulator
GTH07_12945	COG1560	Kdo2-lipid A biosynthetic process
GTH07_12950	COG1560	Kdo2-lipid A biosynthetic process
GTH07_12955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GTH07_12960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GTH07_12965	COG1561	YicC-like family, N-terminal region
GTH07_12970	COG2862	Uncharacterized protein family, UPF0114
GTH07_12975	COG1263	PTS System
GTH07_12975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH07_12980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTH07_13000	COG1120	ATPase activity
GTH07_13005	COG4774	siderophore transport
GTH07_13010	COG1132	(ABC) transporter
GTH07_13025	COG0514	ATP-dependent DNA helicase (RecQ)
GTH07_13030	COG2962	Rard protein
GTH07_13045	COG1280	lysine exporter protein (LysE YggA)
GTH07_13050	COG0210	DNA helicase
GTH07_13060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GTH07_13065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTH07_13075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH07_13080	COG0601	transmembrane transport
GTH07_13085	COG0747	negative chemotaxis
GTH07_13135	COG1309	transcriptional regulator
GTH07_13140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTH07_13145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTH07_13150	COG2960	long-chain fatty acid transporting porin activity
GTH07_13155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GTH07_13160	COG0583	DNA-binding transcription factor activity
GTH07_13230	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GTH07_13235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTH07_13240	COG1739	Uncharacterized protein family UPF0029
GTH07_13245	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTH07_13245	COG1024	Enoyl-CoA hydratase
GTH07_13250	COG0183	Belongs to the thiolase family
GTH07_13255	COG0583	DNA-binding transcription factor activity
GTH07_13260	COG2814	Major facilitator Superfamily
GTH07_13265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTH07_13270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GTH07_13275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GTH07_13280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GTH07_13285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GTH07_13290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTH07_13295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GTH07_13305	COG0356	it plays a direct role in the translocation of protons across the membrane
GTH07_13310	COG3312	ion transport
GTH07_13315	COG1475	DNA binding
GTH07_13320	COG1192	Involved in chromosome partitioning
GTH07_13325	COG0357	Ribosomal RNA small subunit methyltransferase G
GTH07_13330	COG0445	tRNA wobble uridine modification
GTH07_13335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTH07_13340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GTH07_13345	COG0706	membrane insertase activity
GTH07_13355	COG0594	ribonuclease P activity
GTH07_13360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GTH07_13365	COG1126	abc transporter atp-binding protein
GTH07_13410	COG0217	transcriptional regulatory protein
GTH07_13415	COG2084	Dehydrogenase
GTH07_13430	COG2909	trisaccharide binding
GTH07_13435	COG0058	SHG alpha-glucan phosphorylase activity
GTH07_13440	COG1640	4-alpha-glucanotransferase
GTH07_13445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GTH07_13455	COG3501	Rhs element vgr protein
GTH07_13460	COG4104	PAAR repeat-containing protein
GTH07_13490	COG0471	metal ion transport
GTH07_13495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GTH07_13535	COG0671	phosphoesterase, PA-phosphatase related
GTH07_13540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GTH07_13550	COG1999	signal sequence binding
GTH07_13565	COG0786	glutamate:sodium symporter activity
GTH07_13585	COG1566	PFAM secretion protein HlyD family protein
GTH07_13610	COG0813	purine-nucleoside phosphorylase activity
GTH07_13615	COG3272	Protein of unknown function (DUF1722)
GTH07_13625	COG0415	Belongs to the DNA photolyase family
GTH07_13630	COG1388	LysM domain
GTH07_13630	COG1376	ErfK ybiS ycfS ynhG family protein
GTH07_13640	COG0513	Belongs to the DEAD box helicase family
GTH07_13645	COG1770	oligopeptidase
GTH07_13675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTH07_13680	COG0573	inorganic phosphate transmembrane transporter activity
GTH07_13685	COG0581	inorganic phosphate transmembrane transporter activity
GTH07_13690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTH07_13705	COG3314	Sporulation integral membrane protein YlbJ
GTH07_13710	COG0659	secondary active sulfate transmembrane transporter activity
GTH07_13720	COG0739	heme binding
GTH07_13725	COG5001	Diguanylate cyclase
GTH07_13725	COG3300	MHYT domain
GTH07_13730	COG0583	DNA-binding transcription factor activity
GTH07_13735	COG2814	Major facilitator Superfamily
GTH07_13755	COG1301	dicarboxylic acid transport
GTH07_13765	COG1342	Belongs to the UPF0251 family
GTH07_13795	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTH07_13800	COG0673	inositol 2-dehydrogenase activity
GTH07_13810	COG2200	EAL domain
GTH07_13810	COG2771	luxR family
GTH07_13815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH07_13825	COG0564	pseudouridine synthase activity
GTH07_13890	COG3829	transcription factor binding
GTH07_13915	COG3409	Peptidoglycan-binding domain 1 protein
GTH07_13915	COG3501	Rhs element vgr protein
GTH07_13930	COG1869	D-ribose catabolic process
GTH07_13935	COG1129	ABC transporter
GTH07_13940	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTH07_13945	COG1879	ABC-type sugar transport system periplasmic component
GTH07_13950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH07_13955	COG1609	Transcriptional regulator
GTH07_13965	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GTH07_13975	COG0584	glycerophosphoryl diester phosphodiesterase
GTH07_13980	COG2271	Major facilitator Superfamily
GTH07_14015	COG0579	oxidoreductase
GTH07_14025	COG0242	peptide deformylase activity
GTH07_14040	COG1017	nitric oxide dioxygenase activity
GTH07_14040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTH07_14045	COG1320	monovalent cation:proton antiporter activity
GTH07_14050	COG2212	antiporter activity
GTH07_14055	COG1863	multisubunit Na H antiporter MnhE subunit
GTH07_14060	COG0651	ATP synthesis coupled electron transport
GTH07_14065	COG1006	Multisubunit Na H antiporter MnhC subunit
GTH07_14070	COG2111	Na H antiporter
GTH07_14070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTH07_14080	COG0589	response to stress
GTH07_14085	COG0814	amino acid
GTH07_14100	COG3530	Putative quorum-sensing-regulated virulence factor
GTH07_14115	COG1278	Cold shock
GTH07_14130	COG2304	oxidoreductase activity
GTH07_14150	COG0714	Associated with various cellular activities
GTH07_14155	COG0840	transmembrane signaling receptor activity
GTH07_14170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTH07_14175	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTH07_14185	COG3604	Transcriptional regulator
GTH07_14190	COG1017	nitric oxide dioxygenase activity
GTH07_14190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTH07_14195	COG1278	Cold shock
GTH07_14200	COG3036	rescue of stalled ribosome
GTH07_14225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GTH07_14225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTH07_14230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTH07_14240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTH07_14250	COG0516	GMP reductase activity
GTH07_14290	COG0513	Belongs to the DEAD box helicase family
GTH07_14295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTH07_14300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GTH07_14305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GTH07_14310	COG0784	Response regulator, receiver
GTH07_14310	COG3437	response regulator, receiver
GTH07_14315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH07_14315	COG4191	Histidine kinase
GTH07_14325	COG1757	Na H antiporter
GTH07_14330	COG2814	Major facilitator Superfamily
GTH07_14340	COG3706	GGDEF domain
GTH07_14345	COG3240	lipase activity
GTH07_14355	COG0840	transmembrane signaling receptor activity
GTH07_14360	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GTH07_14365	COG5380	lipid catabolic process
GTH07_14390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH07_14395	COG4605	iron ion homeostasis
GTH07_14400	COG4604	ABC transporter, ATP-binding protein
GTH07_14405	COG2207	Transcriptional regulator
GTH07_14420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTH07_14440	COG0745	RESPONSE REGULATOR receiver
GTH07_14450	COG3623	hexulose-6-phosphate isomerase
GTH07_14455	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GTH07_14460	COG0561	phosphatase activity
GTH07_14495	COG0366	Alpha amylase catalytic
GTH07_14520	COG0745	RESPONSE REGULATOR receiver
GTH07_14525	COG5002	protein histidine kinase activity
GTH07_14550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTH07_14565	COG2814	Major facilitator Superfamily
GTH07_14580	COG1686	Belongs to the peptidase S11 family
GTH07_14610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTH07_14610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTH07_14615	COG0509	glycine decarboxylation via glycine cleavage system
GTH07_14620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTH07_14630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GTH07_14640	COG3039	Transposase
GTH07_14665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GTH07_14675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GTH07_14680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GTH07_14805	COG0456	acetyltransferase
GTH07_14825	COG0346	lactoylglutathione lyase activity
GTH07_14950	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTH07_15010	COG0346	lactoylglutathione lyase activity
GTH07_15030	COG3040	lipid binding
GTH07_15045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GTH07_15085	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTH07_15230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH07_15420	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTH07_15445	COG3040	lipid binding
GTH07_15495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GTH07_15500	COG4977	sequence-specific DNA binding
GTH07_15590	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GTH07_15595	COG2944	sequence-specific DNA binding
GTH07_15610	COG3039	Transposase
GTH07_15630	COG0346	lactoylglutathione lyase activity
GTH07_15790	COG0346	lactoylglutathione lyase activity
GTH07_15810	COG1328	CTP reductase activity
GTH07_15815	COG0602	queuosine metabolic process
GTH07_15825	COG4067	protein conserved in archaea
GTH07_15825	COG0189	ligase activity
GTH07_15830	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GTH07_15830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH07_15830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTH07_15835	COG1105	Belongs to the carbohydrate kinase PfkB family
GTH07_15840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH07_15840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH07_15845	COG1609	Transcriptional regulator
GTH07_15850	COG0420	3'-5' exonuclease activity
GTH07_15855	COG0419	ATPase involved in DNA repair
GTH07_15860	COG0784	Response regulator, receiver
GTH07_15860	COG2205	protein histidine kinase activity
GTH07_15865	COG0156	8-amino-7-oxononanoate synthase activity
GTH07_15880	COG0523	cobalamin synthesis protein
GTH07_15895	COG0674	pyruvate-flavodoxin oxidoreductase activity
GTH07_15895	COG1013	pyruvate-flavodoxin oxidoreductase activity
GTH07_15895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GTH07_15895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTH07_15900	COG2205	protein histidine kinase activity
GTH07_15905	COG0745	RESPONSE REGULATOR receiver
GTH07_15910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTH07_15915	COG0586	Pfam SNARE associated Golgi protein
GTH07_15925	COG2200	EAL domain
GTH07_15935	COG3038	cytochrome b561
GTH07_15945	COG2116	formate transmembrane transporter activity
GTH07_15950	COG0583	DNA-binding transcription factor activity
GTH07_15960	COG3593	DNA synthesis involved in DNA repair
GTH07_15965	COG0737	Belongs to the 5'-nucleotidase family
GTH07_15980	COG2824	Alkylphosphonate utilization operon protein PhnA
GTH07_16010	COG2199	diguanylate cyclase activity
GTH07_16030	COG3706	GGDEF domain
GTH07_16045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GTH07_16050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GTH07_16060	COG0745	RESPONSE REGULATOR receiver
GTH07_16075	COG3140	Belongs to the UPF0181 family
GTH07_16105	COG0023	Translation Initiation Factor
GTH07_16125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH07_16125	COG0045	succinate-CoA ligase (ADP-forming) activity
GTH07_16125	COG1042	CoA-binding domain protein
GTH07_16130	COG0583	DNA-binding transcription factor activity
GTH07_16135	COG1629	transport
GTH07_16135	COG4771	TonB-dependent receptor
GTH07_16155	COG2050	protein possibly involved in aromatic compounds catabolism
GTH07_16175	COG0625	glutathione transferase activity
GTH07_16190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTH07_16195	COG4172	Belongs to the ABC transporter superfamily
GTH07_16200	COG4239	(ABC) transporter, permease
GTH07_16205	COG4174	ABC transporter (Permease)
GTH07_16210	COG4166	transmembrane transport
GTH07_16235	COG3104	oligopeptide transport
GTH07_16255	COG3842	ATPase activity
GTH07_16265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTH07_16270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTH07_16275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH07_16280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTH07_16285	COG1011	Hydrolase
GTH07_16295	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GTH07_16300	COG1970	mechanosensitive ion channel activity
GTH07_16305	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GTH07_16310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTH07_16310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTH07_16315	COG0302	gtp cyclohydrolase
GTH07_16325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTH07_16335	COG2897	thiosulfate sulfurtransferase activity
GTH07_16340	COG2390	Transcriptional regulator
GTH07_16345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GTH07_16350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTH07_16370	COG3039	Transposase
GTH07_16385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTH07_16410	COG0583	DNA-binding transcription factor activity
GTH07_16415	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GTH07_16455	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTH07_16500	COG1263	PTS System
GTH07_16500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTH07_16505	COG1609	Transcriptional regulator
GTH07_16510	COG1621	beta-fructofuranosidase activity
GTH07_16515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH07_16520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTH07_16530	COG2885	chlorophyll binding
GTH07_16535	COG0545	Peptidyl-prolyl cis-trans isomerase
GTH07_16540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTH07_16545	COG0840	transmembrane signaling receptor activity
GTH07_16550	COG3069	C4-dicarboxylate transmembrane transporter activity
GTH07_16555	COG1760	l-serine dehydratase
GTH07_16575	COG1609	Transcriptional regulator
GTH07_16580	COG2197	response regulator
GTH07_16585	COG3850	Histidine kinase
GTH07_16590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTH07_16600	COG0243	molybdopterin cofactor binding
GTH07_16620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTH07_16625	COG2197	response regulator
GTH07_16630	COG3851	Histidine kinase
GTH07_16635	COG2271	Major facilitator Superfamily
GTH07_16640	COG1840	ABC-type Fe3 transport system, periplasmic component
GTH07_16650	COG3842	ATPase activity
GTH07_16655	COG3243	poly(R)-hydroxyalkanoic acid synthase
GTH07_16665	COG0183	Belongs to the thiolase family
GTH07_16675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTH07_16680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTH07_16700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTH07_16710	COG1979	alcohol dehydrogenase
GTH07_16725	COG4191	Histidine kinase
GTH07_16735	COG2271	Major facilitator Superfamily
GTH07_16740	COG0469	pyruvate kinase activity
GTH07_16745	COG0784	Response regulator, receiver
GTH07_16745	COG2198	Histidine kinase
GTH07_16745	COG2205	protein histidine kinase activity
GTH07_16750	COG1879	ABC-type sugar transport system periplasmic component
GTH07_16755	COG1803	Methylglyoxal synthase
GTH07_16760	COG1335	isochorismatase
GTH07_16765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GTH07_16780	COG0210	DNA helicase
GTH07_16785	COG1289	transmembrane transporter activity
GTH07_16815	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GTH07_16820	COG4149	molybdate abc transporter
GTH07_16825	COG0725	ABC transporter, periplasmic molybdate-binding protein
GTH07_16830	COG1492	cobalamin metabolic process
GTH07_16860	COG5002	protein histidine kinase activity
GTH07_16860	COG0784	Response regulator, receiver
GTH07_16865	COG1879	ABC-type sugar transport system periplasmic component
GTH07_16875	COG2827	Endonuclease containing a URI domain
GTH07_16880	COG3132	Protein of unknown function, DUF480
GTH07_16890	COG2926	Belongs to the UPF0265 family
GTH07_16900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GTH07_16905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTH07_16910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTH07_16915	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GTH07_16920	COG0247	lactate metabolic process
GTH07_16925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTH07_16930	COG3118	belongs to the thioredoxin family
GTH07_16960	COG0583	DNA-binding transcription factor activity
GTH07_16965	COG4160	amino acid transport
GTH07_16970	COG4215	(ABC) transporter
GTH07_16975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH07_16980	COG1126	abc transporter atp-binding protein
GTH07_16990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GTH07_17000	COG0494	nUDIX hydrolase
GTH07_17005	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GTH07_17015	COG1309	transcriptional regulator
GTH07_17020	COG0513	Belongs to the DEAD box helicase family
GTH07_17025	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GTH07_17030	COG0814	amino acid
GTH07_17035	COG0840	transmembrane signaling receptor activity
GTH07_17040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTH07_17045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GTH07_17055	COG1984	allophanate hydrolase subunit 2
GTH07_17070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GTH07_17075	COG4181	ATPase activity
GTH07_17085	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTH07_17090	COG1716	ATPase activity
GTH07_17090	COG5001	Diguanylate cyclase
GTH07_17100	COG0484	heat shock protein binding
GTH07_17140	COG0546	phosphoglycolate phosphatase activity
GTH07_17155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTH07_17160	COG1368	sulfuric ester hydrolase activity
GTH07_17170	COG0513	Belongs to the DEAD box helicase family
GTH07_17185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTH07_17195	COG3046	protein related to deoxyribodipyrimidine photolyase
GTH07_17200	COG3397	chitin binding
GTH07_17205	COG3227	Zinc metalloprotease (Elastase)
GTH07_17215	COG0010	Belongs to the arginase family
GTH07_17220	COG1166	arginine decarboxylase activity
GTH07_17230	COG2239	Acts as a magnesium transporter
GTH07_17235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTH07_17240	COG0459	protein refolding
GTH07_17250	COG0527	aspartate kinase activity
GTH07_17255	COG0662	Cupin 2, conserved barrel domain protein
GTH07_17260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTH07_17265	COG0456	acetyltransferase
GTH07_17270	COG2154	pterin-4-alpha-carbinolamine dehydratase
GTH07_17275	COG3186	Phenylalanine-4-hydroxylase
GTH07_17280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTH07_17295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTH07_17320	COG1253	flavin adenine dinucleotide binding
GTH07_17325	COG1765	OsmC-like protein
GTH07_17350	COG0531	amino acid
GTH07_17365	COG3279	Response regulator of the LytR AlgR family
GTH07_17370	COG3275	phosphorelay sensor kinase activity
GTH07_17385	COG0577	efflux transmembrane transporter activity
GTH07_17385	COG1136	(ABC) transporter
GTH07_17390	COG1136	(ABC) transporter
GTH07_17400	COG4989	oxidoreductase activity
GTH07_17405	COG0366	Alpha amylase catalytic
GTH07_17415	COG2067	long-chain fatty acid transport protein
GTH07_17420	COG2267	carboxylic ester hydrolase activity
GTH07_17430	COG3227	Zinc metalloprotease (Elastase)
GTH07_17440	COG3047	cAMP biosynthetic process
GTH07_17450	COG1686	Belongs to the peptidase S11 family
GTH07_17455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTH07_17460	COG1271	oxidase subunit
GTH07_17465	COG1294	oxidase, subunit
GTH07_17480	COG3048	D-serine ammonia-lyase activity
GTH07_17485	COG0583	DNA-binding transcription factor activity
GTH07_17530	COG1063	alcohol dehydrogenase
GTH07_17555	COG0346	lactoylglutathione lyase activity
GTH07_17580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTH07_17585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GTH07_17590	COG0363	glucosamine-6-phosphate deaminase activity
GTH07_17595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTH07_17620	COG1929	Belongs to the glycerate kinase type-1 family
GTH07_17625	COG2610	gluconate transmembrane transporter activity
GTH07_17630	COG3835	regulator
GTH07_17640	COG0748	coenzyme F420 binding
GTH07_17645	COG3721	Heme iron utilization protein
GTH07_17655	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GTH07_17660	COG0811	peptide transport
GTH07_17665	COG0848	biopolymer transport protein
GTH07_17670	COG4558	Periplasmic binding protein
GTH07_17675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTH07_17680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GTH07_17715	COG0633	Ferredoxin
GTH07_17715	COG3217	Mosc domain protein beta barrel domain protein
GTH07_17715	COG0633	Ferredoxin
GTH07_17715	COG3217	Mosc domain protein beta barrel domain protein
GTH07_17720	COG0418	dihydroorotase activity
GTH07_17730	COG3152	Membrane
GTH07_17740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTH07_17745	COG2354	Protein conserved in bacteria
GTH07_17750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTH07_17755	COG1278	Cold shock
GTH07_17780	COG2199	diguanylate cyclase activity
GTH07_17785	COG1349	DNA-binding transcription factor activity
GTH07_17800	COG3833	ABC-type maltose transport systems, permease component
GTH07_17805	COG1175	transmembrane transport
GTH07_17815	COG3842	ATPase activity
GTH07_17820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTH07_17835	COG0393	Putative heavy-metal-binding
GTH07_17845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTH07_17850	COG0784	Response regulator, receiver
GTH07_17850	COG0835	chemotaxis
GTH07_17855	COG1846	Transcriptional regulator
GTH07_17860	COG3706	GGDEF domain
GTH07_17895	COG0583	DNA-binding transcription factor activity
GTH07_17900	COG5001	Diguanylate cyclase
GTH07_17910	COG1741	Belongs to the pirin family
GTH07_17915	COG3123	guanosine phosphorylase activity
GTH07_17925	COG2211	Major facilitator Superfamily
GTH07_17930	COG0840	transmembrane signaling receptor activity
GTH07_17935	COG1067	ATP-dependent peptidase activity
GTH07_17945	COG4172	Belongs to the ABC transporter superfamily
GTH07_17965	COG0583	DNA-binding transcription factor activity
GTH07_17975	COG1620	l-lactate permease
GTH07_17990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GTH07_18000	COG0840	transmembrane signaling receptor activity
GTH07_18010	COG0513	Belongs to the DEAD box helicase family
GTH07_18015	COG0583	DNA-binding transcription factor activity
GTH07_18025	COG1902	pentaerythritol trinitrate reductase activity
GTH07_18035	COG1132	(ABC) transporter
GTH07_18045	COG1902	pentaerythritol trinitrate reductase activity
GTH07_18055	COG1280	lysine exporter protein (LysE YggA)
GTH07_18060	COG2207	Transcriptional regulator
GTH07_18080	COG1846	Transcriptional regulator
GTH07_18085	COG1764	response to oxidative stress
GTH07_18090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTH07_18095	COG0697	spore germination
GTH07_18105	COG0700	Nucleoside recognition
GTH07_18110	COG3366	ferrous iron transmembrane transporter activity
GTH07_18115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTH07_18125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTH07_18130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GTH07_18135	COG2259	Doxx family
GTH07_18160	COG0363	glucosamine-6-phosphate deaminase activity
GTH07_18175	COG4580	involved in the transport of maltose and maltodextrins
GTH07_18190	COG0840	transmembrane signaling receptor activity
GTH07_18205	COG0840	transmembrane signaling receptor activity
GTH07_18215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTH07_18220	COG1126	abc transporter atp-binding protein
GTH07_18230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTH07_18235	COG4597	amino acid ABC transporter
GTH07_18240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTH07_18250	COG0739	heme binding
GTH07_18255	COG2213	PTS system mannitol-specific
GTH07_18255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTH07_18260	COG0246	Mannitol dehydrogenase
GTH07_18265	COG3722	fumarate hydratase activity
GTH07_18270	COG0673	inositol 2-dehydrogenase activity
GTH07_18300	COG2910	NAD(P)H-binding
GTH07_18310	COG0840	transmembrane signaling receptor activity
GTH07_18315	COG4221	oxidoreductase activity
GTH07_18325	COG1901	pseudouridine methyltransferase
GTH07_18330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTH07_18340	COG0531	amino acid
GTH07_18345	COG1982	Orn Lys Arg decarboxylase major
GTH07_18375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTH07_18400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GTH07_18440	COG0745	RESPONSE REGULATOR receiver
GTH07_18465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTH07_18470	COG0840	transmembrane signaling receptor activity
GTH07_18475	COG0835	chemotaxis
GTH07_18480	COG0835	chemotaxis
GTH07_18485	COG0643	Histidine kinase
GTH07_18485	COG2198	Histidine kinase
GTH07_18505	COG0601	transmembrane transport
GTH07_18510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTH07_18520	COG2194	sulfuric ester hydrolase activity
GTH07_18525	COG0642	Histidine kinase
GTH07_18560	COG1444	tRNA N-acetyltransferase activity
GTH07_18565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine