locus-tag class description VC0395_0001 ENOG4105CXY transporter VC0395_0002 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase VC0395_0004 ENOG4108I5U Uridine phosphorylase VC0395_0005 ENOG4106Z1T Nicotinamide Mononucleotide Transporter VC0395_0006 ENOG4105ETE Transcriptional regulator (LacI family VC0395_0007 ENOG4108RVA ribokinase VC0395_0008 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VC0395_0009 ENOG4105CNN ABC, transporter VC0395_0010 ENOG4105C2J ABC transporter VC0395_0011 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) VC0395_0014 ENOG4105CS6 Rhs element vgr protein VC0395_0020 ENOG4108JUB Transcriptional regulator VC0395_0021 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VC0395_0035 ENOG4105D3G Pseudouridine synthase VC0395_0037 ENOG4107VXZ Hydrolase VC0395_0038 ENOG4105BZU Histidine kinase VC0395_0040 ENOG4105D9R oxidoreductase VC0395_0041 ENOG4107RH7 Nicotinate phosphoribosyltransferase VC0395_0052 ENOG4105CK2 sodium dicarboxylate symporter VC0395_0056 ENOG4108Z4X TRANSCRIPTIONal VC0395_0057 ENOG4105E5M Multidrug resistance protein D VC0395_0058 ENOG4105EQ2 LysR family Transcriptional regulator VC0395_0059 ENOG4105BZU Histidine kinase VC0395_0060 ENOG4105DR5 peptidase VC0395_0062 ENOG4105CHH sulfate transporter VC0395_0063 ENOG4105DWD nucleoside recognition domain protein VC0395_0065 ENOG4105BZU Histidine kinase VC0395_0066 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VC0395_0067 ENOG4105E2Z phosphate ABC transporter (Permease VC0395_0068 ENOG4105C8U phosphate abc transporter VC0395_0069 ENOG4105CVA phosphate VC0395_0075 ENOG4105CUG Oligopeptidase b VC0395_0076 ENOG4105C1J atp-dependent rna helicase VC0395_0079 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein VC0395_0080 ENOG4105CVP deoxyribo-dipyrimidine photolyase VC0395_0082 ENOG4107SEY Conserved Protein VC0395_0083 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VC0395_0086 ENOG4106TD9 Diguanylate cyclase VC0395_0087 ENOG4105KK7 inner membrane protein YiaW VC0395_0088 ENOG4105EFX secretion protein, HlyD family VC0395_0091 ENOG4105YE1 PilZ domain VC0395_0092 ENOG4105D6U Sodium Glutamate Symporter VC0395_0098 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) VC0395_0099 ENOG4105EYK Phosphatidylglycerophosphatase B VC0395_0103 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0107 ENOG4108Q67 UPF0319 protein VC0395_0108 ENOG4105C8P )-transporter VC0395_0110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VC0395_0115 ENOG4105CS6 Rhs element vgr protein VC0395_0116 ENOG4108WC9 type VI secretion system effector, hcp1 family VC0395_0117 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) VC0395_0118 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) VC0395_0119 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) VC0395_0120 ENOG41061ZR Transcriptional regulator VC0395_0121 ENOG4108YYI Protein of unknown function (DUF2810) VC0395_0122 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0123 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VC0395_0124 ENOG4105CDY transcriptional regulatory protein VC0395_0131 ENOG4106RMF ParB family VC0395_0132 ENOG4107RUE extracellular solute-binding protein family 1 VC0395_0133 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) VC0395_0139 ENOG4105XJC Two component transcriptional regulator (Winged helix family VC0395_0140 ENOG4105DHQ Histidine kinase VC0395_0141 ENOG4105DIJ Phosphoethanolamine transferase VC0395_0142 ENOG4108JQ6 ABC transporter VC0395_0143 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VC0395_0144 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VC0395_0147 ENOG4108VYJ response regulator receiver protein VC0395_0148 ENOG4105CBS Chea signal transduction histidine kinase VC0395_0149 ENOG4108V3W Chemotaxis protein, CheW VC0395_0150 ENOG4108V3W Chemotaxis protein, CheW VC0395_0151 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0152 ENOG4105BZU Histidine kinase VC0395_0153 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) VC0395_0154 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VC0395_0155 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0157 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VC0395_0159 ENOG4108JJA ABC, transporter VC0395_0162 ENOG4107QZV Type I secretion membrane fusion protein VC0395_0163 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) VC0395_0165 ENOG4105E6M Sulphatase-modifying factor protein VC0395_0169 ENOG4105C26 Dehydrogenase VC0395_0171 ENOG4105CK7 Sodium proline symporter VC0395_0173 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0174 ENOG4105EW9 transcriptional regulator AsnC family VC0395_0175 ENOG4107RGH Aldehyde dehydrogenase VC0395_0179 ENOG4105CXN decarboxylase VC0395_0180 ENOG4105D5Q Arginine ornithine antiporter VC0395_0181 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) VC0395_0183 ENOG4105JQN Transcriptional regulator VC0395_0184 ENOG4105EMU Dehydrogenase VC0395_0185 ENOG41069D7 Methyl-accepting chemotaxis VC0395_0186 ENOG4105JQN Transcriptional regulator VC0395_0187 ENOG4108RYK Nad-dependent epimerase dehydratase VC0395_0193 ENOG4105EP9 oxidoreductase VC0395_0194 ENOG4105E61 Mannitol repressor protein VC0395_0195 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase VC0395_0196 ENOG4105CTS PTS system mannitol-specific VC0395_0198 ENOG4105DR5 peptidase VC0395_0200 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain VC0395_0201 ENOG4105EZ7 amino acid ABC transporter VC0395_0202 ENOG4106TNF Periplasmic binding protein VC0395_0204 ENOG4105CDA abc transporter atp-binding protein VC0395_0205 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VC0395_0207 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0210 ENOG4108N3W hemolysin secretion protein VC0395_0213 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) VC0395_0214 ENOG4107W52 maltose operon periplasmic protein VC0395_0216 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) VC0395_0221 ENOG4108VGI doxx family VC0395_0222 ENOG4105D03 DNA-3-methyladenine glycosylase II VC0395_0223 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) VC0395_0225 ENOG4105DN9 Na H antiporter VC0395_0226 ENOG41074DU domain protein VC0395_0227 ENOG4108P2H Inner membrane protein YjiG VC0395_0228 ENOG4105VW4 glutaredoxin 3 VC0395_0229 ENOG4108SXK Transporter Drug Metabolite Exporter family VC0395_0231 ENOG4108ZHJ Organic hydroperoxide resistance protein VC0395_0232 ENOG4105K56 Transcriptional regulator VC0395_0240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VC0395_0242 ENOG4105BZ1 (ABC) transporter VC0395_0244 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VC0395_0246 ENOG4105CR8 Transcriptional regulator VC0395_0248 ENOG4105C1J atp-dependent rna helicase VC0395_0250 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VC0395_0252 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) VC0395_0254 ENOG4105DMF Dehydrogenase VC0395_0255 ENOG4105DAA L-lactate VC0395_0257 ENOG4105CC0 LysR family Transcriptional regulator VC0395_0259 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0260 ENOG4105E89 ABC transporter VC0395_0261 ENOG4108JQ5 ABC transporter VC0395_0263 ENOG4105DAN ATP-dependent protease VC0395_0265 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0267 ENOG4105E5W Transporter VC0395_0270 ENOG4105NBK UPF0345 protein VC0395_0271 ENOG4105EUB pirin domain protein VC0395_0273 ENOG4108K0B C-di-gmp phosphodiesterase VC0395_0274 ENOG4105ETT transcriptional Regulator, LysR family VC0395_0279 ENOG4105BZU Histidine kinase VC0395_0283 ENOG4106TD9 Diguanylate cyclase VC0395_0284 ENOG4105K56 Transcriptional regulator VC0395_0285 ENOG4107R88 Chemotaxis protein (CheV) VC0395_0286 ENOG4105KQ5 peptidylprolyl cis-trans isomerase VC0395_0287 ENOG41086KC Transcriptional regulator VC0395_0288 ENOG4105K8R UPF0145 protein VC0395_0291 ENOG4108HK0 -acetyltransferase VC0395_0292 ENOG4108IJ9 (ABC) transporter VC0395_0294 ENOG4107FKK extracellular solute-binding protein family 1 VC0395_0295 ENOG4105D56 permease protein VC0395_0296 ENOG4105EG2 ABC transporter, permease VC0395_0299 ENOG4105E98 transcriptional regulator DeoR family VC0395_0300 ENOG4105BZU Histidine kinase VC0395_0303 ENOG4105EQD regulatoR VC0395_0306 ENOG4105VEQ Cold shock protein VC0395_0307 ENOG4108ESY Metal dependent phosphohydrolase VC0395_0308 ENOG4105CKW Inner membrane protein yedI VC0395_0309 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) VC0395_0311 ENOG4105KAF membrAne VC0395_0313 ENOG4105EKE dihydroorotase VC0395_0315 ENOG4105QVC MOSC domain-containing protein VC0395_0315 ENOG4105QVC MOSC domain-containing protein VC0395_0316 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0322 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) VC0395_0323 ENOG4105EHG Permease protein VC0395_0324 ENOG4107R4I Periplasmic binding protein VC0395_0325 ENOG4106GFD transport protein VC0395_0326 ENOG41090AP transport protein VC0395_0327 ENOG4105WQ5 TonB family VC0395_0328 ENOG4105D4P Coproporphyrinogen iii oxidase VC0395_0329 ENOG41090JE Utilization Protein VC0395_0330 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related VC0395_0331 ENOG4108NVR Methyl-accepting chemotaxis VC0395_0332 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR VC0395_0333 ENOG4105C6Z Gluconate VC0395_0334 ENOG4105BZW Glycerate kinase VC0395_0339 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) VC0395_0340 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) VC0395_0341 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase VC0395_0342 ENOG4105DHT Metal Dependent Phosphohydrolase VC0395_0348 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase VC0395_0349 ENOG4105EXG Transcriptional regulator VC0395_0351 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) VC0395_0352 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VC0395_0353 ENOG4105CPQ Dehydrogenase VC0395_0361 ENOG4105W8I Transcriptional regulator VC0395_0362 ENOG4105BZC d-serine deaminase VC0395_0364 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VC0395_0365 ENOG4105C4M (Ubiquinol oxidase) subunit I VC0395_0367 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VC0395_0368 ENOG41061WM D-Alanyl-D-Alanine VC0395_0370 ENOG4105EIF outer membrane protein W VC0395_0371 ENOG4105D4Y metalloprotease VC0395_0372 ENOG4107SDU Methyl-accepting chemotaxis VC0395_0373 ENOG4108M0H Extracellular lipase VC0395_0374 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VC0395_0377 ENOG4107T9C Alpha amylase catalytic region VC0395_0378 ENOG4107RGM aldo keto reductase VC0395_0382 ENOG4105C19 ABC transporter VC0395_0383 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VC0395_0386 ENOG4108HRK Histidine kinase VC0395_0387 ENOG4108VAC response regulator VC0395_0389 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria VC0395_0390 ENOG4105DVH amino acid VC0395_0395 ENOG4107YWA deoxycytidylate deaminase VC0395_0397 ENOG4108UKZ OsmC family VC0395_0398 ENOG4105C37 (CBS) domain VC0395_0399 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) VC0395_0402 ENOG4105EGI Transcriptional regulator VC0395_0403 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VC0395_0406 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VC0395_0407 ENOG4105MIR Phenylalanine 4-monooxygenase VC0395_0408 ENOG41090A4 Pterin carbinolamine dehydratase VC0395_0409 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase VC0395_0410 ENOG4108JPW Aminotransferase VC0395_0411 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) VC0395_0412 ENOG4105CZK Aspartate kinase VC0395_0414 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VC0395_0415 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VC0395_0416 ENOG4105CJW magnesium transporter VC0395_0419 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) VC0395_0420 ENOG4105CYW agmatinase VC0395_0422 ENOG4105D4Y metalloprotease VC0395_0423 ENOG4108M1A Chitin-binding protein VC0395_0425 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein VC0395_0427 ENOG4105CVA phosphate VC0395_0429 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) VC0395_0430 ENOG4105C1J atp-dependent rna helicase VC0395_0432 ENOG4105E0M Sulfatase VC0395_0433 ENOG4107RE1 Inosine-guanosine kinase VC0395_0436 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VC0395_0445 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase VC0395_0446 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) VC0395_0447 ENOG4105CGF Aromatic amino acid aminotransferase VC0395_0448 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VC0395_0449 ENOG4105DM4 PTS System VC0395_0450 ENOG4105DE4 1-phosphofructokinase VC0395_0451 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein VC0395_0452 ENOG4107B7Y DNA-binding transcriptional regulator FruR VC0395_0454 ENOG4105EYH Exonuclease VC0395_0455 ENOG4108MGY Histidine kinase VC0395_0456 ENOG4107KBT 8-Amino-7-oxononanoate synthase VC0395_0459 ENOG4105CMQ Chloride channel VC0395_0460 ENOG4105CKI cobalamin synthesis protein VC0395_0461 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) VC0395_0462 ENOG4105DFH Transport of potassium into the cell (By similarity) VC0395_0463 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) VC0395_0464 ENOG4105C08 Histidine kinase VC0395_0467 ENOG4108RHM integral membrane protein VC0395_0470 ENOG4105EPM Diguanylate phosphodiesterase VC0395_0472 ENOG4105DS1 cytochrome b561 VC0395_0473 ENOG4108YYC ycei family VC0395_0474 ENOG4105TMB Formate nitrite transporter VC0395_0475 ENOG4105DUM transcriptional regulator, lysR family VC0395_0476 ENOG4108UQ5 membrane protein YcdZ VC0395_0477 ENOG4105CPB ATP-dependent endonuclease of the OLD family VC0395_0478 ENOG4105CGH 5'-nucleotidase VC0395_0479 ENOG4105DU1 integral membrane protein, terc VC0395_0481 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA VC0395_0489 ENOG4105BZU Histidine kinase VC0395_0492 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VC0395_0493 ENOG4105BZU Histidine kinase VC0395_0497 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VC0395_0498 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VC0395_0500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VC0395_0505 ENOG41067QW Transcriptional regulator VC0395_0511 ENOG4105MQ5 zona occludens toxin VC0395_0512 ENOG4107927 Cholera enterotoxin, A subunit VC0395_0513 ENOG4108ZJT translation initiation factor, Sui1 VC0395_0515 ENOG4105CPF Cell wall formation (By similarity) VC0395_0517 ENOG4105CD5 CoA-binding domain protein VC0395_0518 ENOG4105CWB LysR family transcriptional Regulator VC0395_0523 ENOG4105KA0 thioesterase Superfamily protein VC0395_0528 ENOG4105CYM Glutathione S-transferase VC0395_0531 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VC0395_0532 ENOG4108JQ5 ABC transporter VC0395_0533 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component VC0395_0534 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component VC0395_0535 ENOG4105E43 Extracellular solute-binding protein, family 5 VC0395_0540 ENOG4105DUX Transporter VC0395_0543 ENOG4107RCV ABC transporter, permease VC0395_0546 ENOG4107STF Involved in phosphonate degradation (By similarity) VC0395_0547 ENOG4108JPW Aminotransferase VC0395_0548 ENOG4108KAZ Involved in phosphonate degradation (By similarity) VC0395_0549 ENOG4105NXH GreA GreB family elongation factor VC0395_0550 ENOG4105PAD Hydrolase VC0395_0552 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain VC0395_0554 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) VC0395_0556 ENOG4105CKU formyltetrahydrofolate synthetase VC0395_0557 ENOG4105E0X reductase VC0395_0558 ENOG4105EUJ GTP cyclohydrolase i VC0395_0559 ENOG4105CVM Molybdenum cofactor synthesis domain protein VC0395_0560 ENOG4105D06 uba thif-type nad fad binding protein VC0395_0562 ENOG4105KHC sulfurtransferase VC0395_0563 ENOG4107RHR regulatoR VC0395_0564 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VC0395_0565 ENOG4105CV1 Transketolase (EC 2.2.1.1) VC0395_0569 ENOG4105F2I Transposase VC0395_0573 ENOG4108M3J Dehydrogenase VC0395_0576 ENOG4105RA2 Membrane VC0395_0579 ENOG41067V3 Antibiotic biosynthesis monooxygenase VC0395_0580 ENOG4105ETT transcriptional Regulator, LysR family VC0395_0581 ENOG4108RCM Nitroreductase VC0395_0586 ENOG41080HT Transcriptional regulator, arsr family VC0395_0588 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase VC0395_0597 ENOG4105C5Y PTS System VC0395_0598 ENOG4105ETE Transcriptional regulator (LacI family VC0395_0599 ENOG4108HKT sucrose-6-phosphate hydrolase VC0395_0600 ENOG4105D7K pfkb domain protein VC0395_0601 ENOG4105C6V Glycerol-3-phosphate dehydrogenase VC0395_0602 ENOG4108NVR Methyl-accepting chemotaxis VC0395_0603 ENOG4108ZG0 Ompa motb domain protein VC0395_0604 ENOG4108V1T peptidylprolyl cis-trans isomerase VC0395_0605 ENOG4107VXZ Hydrolase VC0395_0606 ENOG4108N3W hemolysin secretion protein VC0395_0607 ENOG4105CEE C4-dicarboxylate transporter VC0395_0608 ENOG4105EJQ L-serine dehydratase VC0395_0612 ENOG4105ETE Transcriptional regulator (LacI family VC0395_0613 ENOG4105WH1 Two component transcriptional regulator luxr family VC0395_0614 ENOG4105BZU Histidine kinase VC0395_0617 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VC0395_0621 ENOG4105DHT Metal Dependent Phosphohydrolase VC0395_0622 ENOG4108KX4 response regulator VC0395_0623 ENOG4105BZU Histidine kinase VC0395_0624 ENOG4105CXY transporter VC0395_0625 ENOG4105C4Y ABC transporter VC0395_0626 ENOG4107RCV ABC transporter, permease VC0395_0627 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VC0395_0628 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class VC0395_0630 ENOG4105CHU acetyl-coa acetyltransferase VC0395_0632 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VC0395_0633 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VC0395_0636 ENOG4105BZU Histidine kinase VC0395_0637 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VC0395_0640 ENOG4108I6A alcohol dehydrogenase VC0395_0641 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta VC0395_0644 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC VC0395_0646 ENOG4105CXY transporter VC0395_0647 ENOG4105CA9 Pyruvate kinase VC0395_0648 ENOG4105BZU Histidine kinase VC0395_0649 ENOG4108SV3 Tmao reductase system periplasmic protein tort VC0395_0650 ENOG4108Z5K methylglyoxal synthase VC0395_0651 ENOG4108RWI nicotinamidase VC0395_0653 ENOG41080IJ Diacylglycerol kinase VC0395_0656 ENOG41088T4 Helicase IV VC0395_0657 ENOG4105EM2 membrane VC0395_0663 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) VC0395_0664 ENOG4105E0C molybdate abc transporter VC0395_0665 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein VC0395_0666 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) VC0395_0671 ENOG4105BZU Histidine kinase VC0395_0673 ENOG4108QGH periplasmic VC0395_0675 ENOG41082IR Excinuclease ABC C subunit domain protein VC0395_0676 ENOG4108YXG UPF0502 protein VC0395_0682 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) VC0395_0683 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VC0395_0686 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A VC0395_0687 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B VC0395_0688 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) VC0395_0689 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VC0395_0690 ENOG4105K63 Thioredoxin VC0395_0697 ENOG4105DUM transcriptional regulator, lysR family VC0395_0698 ENOG4105DMR ABC, transporter VC0395_0699 ENOG4105GBT ABC transporter VC0395_0700 ENOG4106PMH Extracellular solute-binding protein family 3 VC0395_0701 ENOG4105E5Z arginine transporter ATP-binding subunit VC0395_0703 ENOG4105EV2 VWA domain protein interacting with AAA ATPase VC0395_0705 ENOG4108YZ4 nudix hydrolase VC0395_0706 ENOG4105C5W Aldolase VC0395_0707 ENOG4106RE7 Cytochrome VC0395_0708 ENOG4108IG5 Transcriptional regulator VC0395_0709 ENOG4105C1J atp-dependent rna helicase VC0395_0710 ENOG4108ZYK Acyl carrier protein phosphodiesterase VC0395_0712 ENOG4105E0U tyrosine-specific transport protein VC0395_0713 ENOG4108N3W hemolysin secretion protein VC0395_0714 ENOG4105CMR udp-glucose 4-epimerase VC0395_0716 ENOG4105E7W lamb ycsf family protein VC0395_0718 ENOG4107R7A Allophanate hydrolase subunit 2 VC0395_0720 ENOG4105C6Y Udp-glucose 6-dehydrogenase VC0395_0722 ENOG4105CV6 ABC transporter, permease VC0395_0723 ENOG4108I0Y (ABC) transporter VC0395_0725 ENOG4105RKW reductase (By VC0395_0728 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VC0395_0740 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase VC0395_0751 ENOG4108RS6 transposase VC0395_0796 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase VC0395_0799 ENOG4105EQK -acetyltransferase VC0395_0800 ENOG4105F2I Transposase VC0395_0803 ENOG4105W08 virulence gene repressor rsal VC0395_0804 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system VC0395_0814 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein VC0395_0824 ENOG4105QNF Outer membrane lipoprotein VC0395_0829 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VC0395_0837 ENOG4105YGK Pfam:UPF0157 VC0395_0868 ENOG4105QNF Outer membrane lipoprotein VC0395_0872 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase VC0395_0878 ENOG4105QNF Outer membrane lipoprotein VC0395_0886 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VC0395_0905 ENOG4105N14 lysine exporter protein LysE YggA VC0395_0906 ENOG4105YGK Pfam:UPF0157 VC0395_0912 ENOG4105YGK Pfam:UPF0157 VC0395_0920 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase VC0395_0927 ENOG4108S58 Phenazine biosynthesis protein PhzF VC0395_0929 ENOG4105VDM plasmid maintenance system antidote protein, xre family VC0395_0930 ENOG41080ET plasmid maintenance system killer protein VC0395_0933 ENOG4105YGK Pfam:UPF0157 VC0395_0939 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) VC0395_0940 ENOG41082NX 50s ribosomal protein l35 VC0395_0941 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) VC0395_0942 ENOG4105C22 threonyL-tRNA synthetase VC0395_0947 ENOG4105F2I Transposase VC0395_0949 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) VC0395_0952 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VC0395_0953 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) VC0395_0955 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor VC0395_0956 ENOG4108RS6 transposase VC0395_0960 ENOG4105DZ1 carboxypeptidase VC0395_0962 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_0963 ENOG4105C2C drug resistance transporter, Bcr CflA VC0395_0966 ENOG4107QVI Methyltransferase, type 11 VC0395_0972 ENOG4105BZU Histidine kinase VC0395_0973 ENOG4105XJC Two component transcriptional regulator (Winged helix family VC0395_0980 ENOG4105DS1 cytochrome b561 VC0395_0986 ENOG410667J hydrolase VC0395_0988 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase VC0395_0990 ENOG4105ETX regulatoR VC0395_0994 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VC0395_0998 ENOG4108IPW abc transporter atp-binding protein VC0395_0999 ENOG4105CM4 permease protein VC0395_1000 ENOG4105DHS permease protein VC0395_1004 ENOG4107G87 m6 family metalloprotease domain protein VC0395_1006 ENOG4107IFA Lipase (EC 3.1.1.3) VC0395_1007 ENOG4108N3W hemolysin secretion protein VC0395_1008 ENOG4106M3D hemolysin VC0395_1009 ENOG4106M3D hemolysin VC0395_1011 ENOG4105KUU lipolytic protein G-D-S-L family VC0395_1013 ENOG4105BZU Histidine kinase VC0395_1015 ENOG4105E5M Multidrug resistance protein D VC0395_1016 ENOG4107S6Z Na H antiporter VC0395_1018 ENOG4105BZU Histidine kinase VC0395_1019 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VC0395_1020 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) VC0395_1021 ENOG4107RA1 nh(3)-dependent nad( ) synthetase VC0395_1023 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VC0395_1024 ENOG4105C1J atp-dependent rna helicase VC0395_1025 ENOG4108RS6 transposase VC0395_1030 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VC0395_1059 ENOG4105ED4 portal protein VC0395_1066 ENOG4105VZ1 Replication Protein VC0395_1075 ENOG4105MEH VC0395_1079 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VC0395_1080 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VC0395_1084 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) VC0395_1085 ENOG4105C5I Dehydrogenase VC0395_1087 ENOG4108UNF response regulator VC0395_1092 ENOG4105VEQ Cold shock protein VC0395_1093 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VC0395_1095 ENOG4108JUA Transcriptional regulator VC0395_1096 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VC0395_1098 ENOG4105D9N nucleoside VC0395_1102 ENOG41069D7 Methyl-accepting chemotaxis VC0395_1103 ENOG4105C7R Atpase associated with various cellular activities aaa_3 VC0395_1111 ENOG4105VEQ Cold shock protein VC0395_1112 ENOG4105BZU Histidine kinase VC0395_1114 ENOG4105VRT cytoplasmic protein VC0395_1117 ENOG4105C0F tryptophanase EC 4.1.99.1 VC0395_1118 ENOG4105CIC tryptophan-specific transport protein VC0395_1119 ENOG4105Q9Y Universal stress protein VC0395_1121 ENOG4105D65 subunit l VC0395_1122 ENOG4105MKQ Monovalent cation H antiporter subunit C VC0395_1123 ENOG4108JPZ Monovalent cation H antiporter subunit D VC0395_1124 ENOG4105SC1 monovalent cation H antiporter subunit E VC0395_1125 ENOG41080TA Multiple resistance and ph regulation protein f VC0395_1126 ENOG4105KJM monovalent cation h antiporter subunit g VC0395_1127 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VC0395_1128 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VC0395_1130 ENOG4105D5U fad dependent oxidoreductase VC0395_1135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_1136 ENOG4105CQZ Histidine kinase VC0395_A0002 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) VC0395_A0003 ENOG4105CEN a g-specific adenine glycosylase VC0395_A0005 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) VC0395_A0006 ENOG4105CSV Glutaminase VC0395_A0007 ENOG4105CSA Coproporphyrinogen iii oxidase VC0395_A0008 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VC0395_A0010 ENOG4105VZ9 UPF0235 protein VC0395_A0011 ENOG4108VIA integral membrane protein VC0395_A0012 ENOG4105II7 pyrroline-5-carboxylate reductase VC0395_A0013 ENOG4105DFA alanine racemase domain protein VC0395_A0014 ENOG4105CZX twitching motility protein VC0395_A0015 ENOG4105CZX twitching motility protein VC0395_A0017 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VC0395_A0018 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) VC0395_A0019 ENOG4108UJU UPF0301 protein VC0395_A0020 ENOG4105D7Z glutathione synthase VC0395_A0021 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) VC0395_A0022 ENOG4105RWS endonuclease I VC0395_A0023 ENOG4105GPY SprT protein VC0395_A0024 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP VC0395_A0026 ENOG4105CV1 Transketolase (EC 2.2.1.1) VC0395_A0027 ENOG4108R4R Iron-regulated virulence regulatory protein VC0395_A0028 ENOG4105D05 Receptor VC0395_A0029 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VC0395_A0030 ENOG4105BZA Phosphoglycerate kinase VC0395_A0031 ENOG4105D2N Aldolase VC0395_A0032 ENOG4105D64 Mechanosensitive ion channel VC0395_A0033 ENOG4108ZUB Lysine exporter protein (Lyse ygga) VC0395_A0034 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) VC0395_A0035 ENOG4105MPN Membrane VC0395_A0037 ENOG4105CA9 Pyruvate kinase VC0395_A0038 ENOG410804X Transcriptional regulator VC0395_A0039 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) VC0395_A0040 ENOG4105CH5 extracellular solute-binding protein, family 7 VC0395_A0044 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VC0395_A0045 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) VC0395_A0046 ENOG4105KTH gatB Yqey VC0395_A0047 ENOG4105VCC 30S ribosomal protein S21 VC0395_A0049 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VC0395_A0051 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) VC0395_A0052 ENOG4107ZVW dihydroneopterin aldolase VC0395_A0053 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VC0395_A0054 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) VC0395_A0056 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) VC0395_A0057 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) VC0395_A0058 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) VC0395_A0059 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) VC0395_A0060 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) VC0395_A0061 ENOG4108K5P (LipO)protein VC0395_A0062 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VC0395_A0063 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) VC0395_A0064 ENOG4105C6T cysteine synthase VC0395_A0065 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein VC0395_A0066 ENOG4108I5D sulfate abc transporter VC0395_A0067 ENOG4105ECW sulfate abc transporter VC0395_A0068 ENOG4108IJ6 ABC transporter VC0395_A0070 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) VC0395_A0071 ENOG4105Y3E Modulates RecA activity (By similarity) VC0395_A0072 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VC0395_A0074 ENOG4105CFH Aspartokinase VC0395_A0075 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) VC0395_A0085 ENOG4107QSA Oxaloacetate decarboxylase VC0395_A0086 ENOG4105D9Q decarboxylase (Beta subunit) VC0395_A0088 ENOG4105W39 Membrane VC0395_A0090 ENOG4105D9M gamma-glutamylcysteine synthetase VC0395_A0091 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) VC0395_A0092 ENOG4108JU6 CBS domain protein VC0395_A0093 ENOG4106KVJ cytochrome C assembly protein VC0395_A0094 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY VC0395_A0095 ENOG4105K5M 30s ribosomal protein S16 VC0395_A0096 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) VC0395_A0097 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) VC0395_A0098 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) VC0395_A0099 ENOG4105C0H protease VC0395_A0100 ENOG4105C0H protease VC0395_A0102 ENOG4105D6Z AFG1 family ATPase VC0395_A0103 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) VC0395_A0104 ENOG4108UJD 30S ribosomal protein S9 VC0395_A0105 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VC0395_A0106 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) VC0395_A0107 ENOG4105EIX cytochrome c1 VC0395_A0108 ENOG4107MKT Stringent starvation protein a VC0395_A0109 ENOG4105KB2 stringent starvation protein b VC0395_A0110 ENOG4105W4M Transport-associated protein VC0395_A0111 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VC0395_A0112 ENOG41082RQ UPF0102 protein VC0395_A0113 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) VC0395_A0114 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VC0395_A0115 ENOG410630P Transcriptional regulator VC0395_A0116 ENOG410630P Transcriptional regulator VC0395_A0117 ENOG4108UGV hypoxanthine phosphoribosyltransferase VC0395_A0118 ENOG41077A9 carbonic anhydrase VC0395_A0119 ENOG4105CHH sulfate transporter VC0395_A0120 ENOG4105DA5 (ABC) transporter VC0395_A0121 ENOG4105E3A (ABC) transporter VC0395_A0122 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) VC0395_A0123 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) VC0395_A0124 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VC0395_A0125 ENOG4105DJ0 Poly(A) Polymerase VC0395_A0126 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) VC0395_A0127 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters VC0395_A0128 ENOG4105PW4 Sugar fermentation stimulation protein homolog VC0395_A0130 ENOG4105CQ7 ATP-dependent helicase VC0395_A0131 ENOG4105BZ4 penicillin-binding protein VC0395_A0132 ENOG4105D78 K07001 NTE family protein VC0395_A0133 ENOG4107QIJ Aconitate hydratase 2 VC0395_A0134 ENOG4105XTV UPF0231 protein VC0395_A0135 ENOG4108YZA Nitrogen regulatory protein pii VC0395_A0139 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VC0395_A0140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VC0395_A0141 ENOG4105E2V Glycosyltransferase 36 VC0395_A0142 ENOG4105E2D ec 3.2.1.52 VC0395_A0143 ENOG4105RD7 BadF BadG BcrA BcrD VC0395_A0145 ENOG4108JQ7 (ABC) transporter VC0395_A0146 ENOG4105C3U ABC transporter VC0395_A0147 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VC0395_A0149 ENOG4107QRA Extracellular solute-binding protein, family 5 VC0395_A0150 ENOG4105BZU Histidine kinase VC0395_A0151 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VC0395_A0152 ENOG4105IPI Membrane VC0395_A0154 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase VC0395_A0156 ENOG4108YX9 iron--sulfur cluster insertion protein erpA VC0395_A0159 ENOG4105DR5 peptidase VC0395_A0160 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) VC0395_A0161 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase VC0395_A0163 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) VC0395_A0164 ENOG4105HBR Rna-binding protein VC0395_A0165 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) VC0395_A0166 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VC0395_A0167 ENOG4105EEI dihydropteroate synthase VC0395_A0168 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) VC0395_A0172 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) VC0395_A0173 ENOG4105CHV Transcription elongation factor NusA VC0395_A0174 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) VC0395_A0175 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) VC0395_A0176 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) VC0395_A0177 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) VC0395_A0178 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) VC0395_A0179 ENOG4105RT1 May be involved in cell division (By similarity) VC0395_A0182 ENOG4106RZ4 Peptidase U32 VC0395_A0183 ENOG4105CFP Peptidase U32 VC0395_A0184 ENOG4105BZU Histidine kinase VC0395_A0185 ENOG4105XPQ lipid carrier protein VC0395_A0186 ENOG4108YYD acetyltransferase VC0395_A0188 ENOG4105BZU Histidine kinase VC0395_A0190 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) VC0395_A0191 ENOG4105C1J atp-dependent rna helicase VC0395_A0192 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) VC0395_A0193 ENOG4105CWM branched-chain amino acid transport system II carrier protein VC0395_A0194 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) VC0395_A0195 ENOG4105CRK lysyL-tRNA synthetase VC0395_A0196 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A0199 ENOG4105CPC Aldo Keto reductase VC0395_A0200 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) VC0395_A0203 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) VC0395_A0204 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase VC0395_A0205 ENOG4105HF0 Membrane VC0395_A0206 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) VC0395_A0207 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) VC0395_A0209 ENOG41063Z6 transcriptional regulator, lysR family VC0395_A0210 ENOG41080HT Transcriptional regulator, arsr family VC0395_A0211 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) VC0395_A0212 ENOG4105CJR Integral membrane protein (MviN VC0395_A0213 ENOG4105DTN riboflavin biosynthesis protein ribF VC0395_A0214 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) VC0395_A0215 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) VC0395_A0216 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase VC0395_A0217 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) VC0395_A0221 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VC0395_A0222 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) VC0395_A0223 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) VC0395_A0224 ENOG4108NEV two component transcriptional regulator, LytTR family VC0395_A0225 ENOG4108HRK Histidine kinase VC0395_A0226 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VC0395_A0229 ENOG4105C5H ABC transporter VC0395_A0230 ENOG4107SC1 transglycosylase VC0395_A0231 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) VC0395_A0232 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VC0395_A0233 ENOG4108K0B C-di-gmp phosphodiesterase VC0395_A0234 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein VC0395_A0236 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA VC0395_A0237 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane VC0395_A0238 ENOG4105C34 Pseudouridine synthase VC0395_A0239 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase VC0395_A0240 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VC0395_A0250 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding VC0395_A0251 ENOG4105CFP Peptidase U32 VC0395_A0252 ENOG4105DH7 May be involved in recombination (By similarity) VC0395_A0253 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VC0395_A0254 ENOG4105BZU Histidine kinase VC0395_A0256 ENOG4105C9X ppx gppa phosphatase VC0395_A0257 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) VC0395_A0258 ENOG4105C8U phosphate abc transporter VC0395_A0259 ENOG4105E2Z phosphate ABC transporter (Permease VC0395_A0260 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VC0395_A0262 ENOG4105CSR polyphosphate kinase 2 VC0395_A0263 ENOG4106N3A copper homeostasis protein cutc VC0395_A0264 ENOG4105D3R alkyl hydroperoxide reductase VC0395_A0265 ENOG4105C5Q Transcriptional regulator VC0395_A0266 ENOG4107QP3 malate synthase g VC0395_A0267 ENOG4108I9X Isocitrate lyase VC0395_A0268 ENOG4105W87 Cbs domain VC0395_A0269 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) VC0395_A0270 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) VC0395_A0271 ENOG4105VIE preprotein translocase, subunit YajC VC0395_A0272 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VC0395_A0273 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VC0395_A0274 ENOG4105ECY inositol monophosphatase VC0395_A0275 ENOG4105CVS RNA methyltransferase TrmH family, group 1 VC0395_A0276 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family VC0395_A0277 ENOG4105C3J Cysteine desulfurase VC0395_A0278 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins VC0395_A0279 ENOG4108Z4V iron-sulfur cluster assembly VC0395_A0280 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) VC0395_A0281 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VC0395_A0282 ENOG4108ZIT Ferredoxin, 2FE-2S VC0395_A0283 ENOG4105WVQ Fe-S assembly protein IscX VC0395_A0284 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VC0395_A0285 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) VC0395_A0286 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs VC0395_A0288 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) VC0395_A0289 ENOG4105CUT histidyl-tRNA synthetase VC0395_A0290 ENOG4105N21 Membrane VC0395_A0291 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VC0395_A0292 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) VC0395_A0294 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VC0395_A0296 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VC0395_A0297 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VC0395_A0299 ENOG4106HK8 GPR1 FUN34 yaaH family protein VC0395_A0300 ENOG4105WQI isochorismatase VC0395_A0301 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase VC0395_A0302 ENOG4105E4F Isochorismate synthase VC0395_A0303 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase VC0395_A0305 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein VC0395_A0306 ENOG4105DQ5 transport system permease protein VC0395_A0307 ENOG4105TVJ transport system, permease VC0395_A0308 ENOG4105E0A ABC, transporter VC0395_A0310 ENOG41064T2 transcriptional regulator, lysR family VC0395_A0311 ENOG4105EUZ Beta-lactamase domain protein VC0395_A0312 ENOG4105BZG amino acid carrier protein VC0395_A0313 ENOG4105MWK D-amino acid dehydrogenase, small subunit VC0395_A0317 ENOG4106YYS transcriptional regulatory protein VC0395_A0318 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VC0395_A0319 ENOG4105D9Q decarboxylase (Beta subunit) VC0395_A0320 ENOG4107QSA Oxaloacetate decarboxylase VC0395_A0323 ENOG4105DUA (citrate (pro-3S)-lyase ligase VC0395_A0324 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) VC0395_A0325 ENOG4105CI0 Citrate lyase VC0395_A0326 ENOG4105CHY citrate lyase, alpha VC0395_A0327 ENOG4105YGP holo-ACP synthase CitX VC0395_A0328 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase VC0395_A0331 ENOG4108Z4U Ferredoxin VC0395_A0332 ENOG4105DZ0 fad dependent oxidoreductase VC0395_A0344 ENOG4105C26 Dehydrogenase VC0395_A0349 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) VC0395_A0353 ENOG4105XB6 Toxin coregulated pilin VC0395_A0356 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C VC0395_A0360 ENOG4107QHF type ii secretion system protein e VC0395_A0361 ENOG4108VEY type ii secretion system VC0395_A0364 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) VC0395_A0365 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A0367 ENOG4105DR5 peptidase VC0395_A0369 ENOG4105F88 accessory colonization factor AcfD VC0395_A0370 ENOG4105F88 accessory colonization factor AcfD VC0395_A0372 ENOG4105DFP Integrase VC0395_A0374 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) VC0395_A0375 ENOG4108Z1B Cyclase dehydrase VC0395_A0376 ENOG4105VDB UPF0125 protein VC0395_A0377 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VC0395_A0378 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) VC0395_A0379 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) VC0395_A0381 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ VC0395_A0382 ENOG4105CFG Acts as a chaperone (By similarity) VC0395_A0383 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) VC0395_A0385 ENOG4106855 Competence protein VC0395_A0389 ENOG4105CFC Transporter VC0395_A0390 ENOG4108Z6B deaminase VC0395_A0392 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) VC0395_A0395 ENOG4107QIK phosphoribosylformylglycinamidine synthase VC0395_A0396 ENOG4108RS6 transposase VC0395_A0400 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) VC0395_A0401 ENOG4108R96 Methyltransferase, YaeB family VC0395_A0402 ENOG4105NRA 50s ribosomal protein l31 type b VC0395_A0404 ENOG4105CFC Transporter VC0395_A0405 ENOG4108UPT UPF0178 protein VC0395_A0408 ENOG4108428 Inherit from COG: -acetyltransferase VC0395_A0410 ENOG4105WP7 tRNA pseudouridine synthase C VC0395_A0411 ENOG4105DR9 pseudouridine synthase VC0395_A0412 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) VC0395_A0413 ENOG4105CTB Polyprenyl synthetase VC0395_A0415 ENOG4105E14 MotA TolQ exbB proton channel VC0395_A0416 ENOG4106VK6 Flagellar motor protein VC0395_A0417 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) VC0395_A0418 ENOG4105ETT transcriptional Regulator, LysR family VC0395_A0419 ENOG4105M08 Membrane VC0395_A0420 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease VC0395_A0421 ENOG4105EWT decarboxylase family VC0395_A0422 ENOG4105BZU Histidine kinase VC0395_A0424 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) VC0395_A0425 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) VC0395_A0426 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein VC0395_A0427 ENOG4105D01 (LipO)protein VC0395_A0428 ENOG4108UMI ABC transporter, permease VC0395_A0429 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VC0395_A0430 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase VC0395_A0431 ENOG4105D4X repressor VC0395_A0432 ENOG4105C5Y PTS System VC0395_A0433 ENOG4105CG3 alpha amylase, catalytic region VC0395_A0439 ENOG4105BZS acriflavin resistance protein VC0395_A0440 ENOG4107ZF2 Phosphatase VC0395_A0441 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase VC0395_A0443 ENOG4108UW5 maltose o-acetyltransferase VC0395_A0448 ENOG4105D7W serine acetyltransferase VC0395_A0450 ENOG4105Q84 sucrose synthase VC0395_A0452 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family VC0395_A0455 ENOG4108MA4 Peptidase M66 VC0395_A0458 ENOG4105D3Q Sugar transferase VC0395_A0460 ENOG4105DAY polysaccharide export protein VC0395_A0461 ENOG4105D75 Capsular exopolysaccharide family VC0395_A0465 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) VC0395_A0467 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) VC0395_A0468 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) VC0395_A0469 ENOG4108Z43 UPF0250 protein VC0395_A0470 ENOG4105DZ1 carboxypeptidase VC0395_A0471 ENOG4105K6T rare lipoprotein A VC0395_A0472 ENOG4105CNI cell division protein FtsW VC0395_A0473 ENOG4105CJN penicillin-binding protein VC0395_A0474 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) VC0395_A0475 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) VC0395_A0476 ENOG4105DJF DNA polymerase III, delta' subunit VC0395_A0477 ENOG4108U2H Rare lipoprotein B VC0395_A0478 ENOG4105C8T Leucyl-tRNA synthetase VC0395_A0479 ENOG4107PAI alpha helical protein VC0395_A0480 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) VC0395_A0481 ENOG4108JU5 Magnesium and cobalt efflux protein VC0395_A0482 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) VC0395_A0483 ENOG4105C9A Phoh family VC0395_A0484 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) VC0395_A0485 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VC0395_A0486 ENOG4105C5Y PTS System VC0395_A0488 ENOG4105KZ7 phosphocarrier protein hpr VC0395_A0489 ENOG4105C6T cysteine synthase VC0395_A0490 ENOG4105EXN Sulfate transport protein CysZ VC0395_A0491 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) VC0395_A0492 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) VC0395_A0493 ENOG41081QG Porin Gram-negative type VC0395_A0495 ENOG4108Z6Z Transcriptional regulator VC0395_A0496 ENOG4105G5H Membrane VC0395_A0497 ENOG4107QX8 SPFH domain, Band 7 family protein VC0395_A0498 ENOG4107QR8 Thioredoxin VC0395_A0500 ENOG4105E1F short-chain dehydrogenase reductase VC0395_A0501 ENOG4105ECP epimerase VC0395_A0502 ENOG4108RE9 Phosphodiesterase VC0395_A0505 ENOG4108TU9 TRANSCRIPTIONal VC0395_A0506 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) VC0395_A0507 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) VC0395_A0508 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) VC0395_A0509 ENOG4105DUX Transporter VC0395_A0511 ENOG4105MDZ Transcriptional activator rfaH VC0395_A0512 ENOG4105CAQ asparagine synthetase VC0395_A0513 ENOG4105CKD glutathione-regulated potassium-efflux system protein VC0395_A0514 ENOG4105E2R ROK family VC0395_A0515 ENOG4105CE4 GlcNAc 6-P deacetylase VC0395_A0516 ENOG4105CI1 PTS System VC0395_A0517 ENOG4105CX6 glutaminyL-tRNA synthetase VC0395_A0520 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) VC0395_A0521 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) VC0395_A0522 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase VC0395_A0523 ENOG4108S3P Sporulation domain protein VC0395_A0524 ENOG4105E96 Colicin v production protein VC0395_A0525 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase VC0395_A0526 ENOG4105D3Y Na H antiporter VC0395_A0527 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) VC0395_A0529 ENOG4105EIY sodium-type flagellar protein motY VC0395_A0530 ENOG4106WH9 Protein of unknown function (DUF2753) VC0395_A0531 ENOG4108UYE Lactoylglutathione lyase VC0395_A0532 ENOG4105CSM endonuclease III VC0395_A0533 ENOG4105DZB Electron transport complex VC0395_A0534 ENOG4108UQQ Electron transport complex VC0395_A0535 ENOG4105D6A Electron transport complex VC0395_A0537 ENOG4108R3D Electron transport complex VC0395_A0540 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) VC0395_A0541 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A0542 ENOG4105CHW UPF0052 protein VC0395_A0544 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VC0395_A0545 ENOG4108RIR Molybdenum cofactor biosynthesis protein VC0395_A0546 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) VC0395_A0547 ENOG4105M00 molybdopterin converting factor, subunit 1 VC0395_A0548 ENOG4108ZAF Molybdopterin VC0395_A0549 ENOG4105BZU Histidine kinase VC0395_A0552 ENOG4108I5U Uridine phosphorylase VC0395_A0554 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) VC0395_A0555 ENOG4105D1F ATP-binding protein VC0395_A0556 ENOG4105DBI uridine monophosphokinase VC0395_A0557 ENOG4108GAE asmA family VC0395_A0558 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase VC0395_A0560 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VC0395_A0561 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VC0395_A0564 ENOG4105CHU acetyl-coa acetyltransferase VC0395_A0565 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VC0395_A0566 ENOG41069NU Nitroreductase VC0395_A0567 ENOG4105EJC lysr family transcriptional regulator VC0395_A0568 ENOG4105I93 response regulator VC0395_A0570 ENOG4105WD1 Membrane VC0395_A0571 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) VC0395_A0572 ENOG4107QMP dna polymerase iii subunits gamma and tau VC0395_A0573 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) VC0395_A0574 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) VC0395_A0575 ENOG4105KRS Proteinase inhibitor VC0395_A0577 ENOG4105UBK short-chain dehydrogenase reductase VC0395_A0578 ENOG4105ERU peptidase VC0395_A0580 ENOG4108XM1 transcriptional regulator AsnC family VC0395_A0581 ENOG4105C29 acyl-CoA thioesterase VC0395_A0585 ENOG4105BZU Histidine kinase VC0395_A0586 ENOG41082YX Transcriptional regulator, arsr family VC0395_A0587 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VC0395_A0594 ENOG4108V1U phospholipid-binding protein VC0395_A0598 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VC0395_A0601 ENOG4107YTP response regulator receiver protein VC0395_A0603 ENOG4105BZU Histidine kinase VC0395_A0604 ENOG4105BZU Histidine kinase VC0395_A0605 ENOG4105BZU Histidine kinase VC0395_A0606 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A0609 ENOG4107QSI ABC, transporter VC0395_A0610 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VC0395_A0611 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VC0395_A0612 ENOG4105C3U ABC transporter VC0395_A0613 ENOG4108JQ7 (ABC) transporter VC0395_A0614 ENOG4105CHF Glutathione S-transferase VC0395_A0615 ENOG4108DNC Involved in acetate metabolism (By similarity) VC0395_A0616 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VC0395_A0617 ENOG4105PQ6 UPF0208 membrane protein VC0395_A0618 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VC0395_A0620 ENOG4105C7J ABC transporter, permease VC0395_A0621 ENOG4108JJB ABC transporter VC0395_A0622 ENOG4105BZU Histidine kinase VC0395_A0623 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) VC0395_A0624 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) VC0395_A0625 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VC0395_A0627 ENOG4105D1H recombination factor protein RarA VC0395_A0628 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) VC0395_A0629 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VC0395_A0630 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) VC0395_A0631 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VC0395_A0632 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VC0395_A0633 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VC0395_A0635 ENOG4105D0M Protease HtpX homolog VC0395_A0637 ENOG4107FW0 short-chain dehydrogenase reductase VC0395_A0640 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase VC0395_A0642 ENOG4105RHG VC0395_A0644 ENOG4107QTF adenylosuccinate lyase VC0395_A0645 ENOG41075W9 High frequency lysogenization protein HflD homolog VC0395_A0646 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) VC0395_A0647 ENOG4107RE1 Inosine-guanosine kinase VC0395_A0649 ENOG4105R8V Transcriptional regulator VC0395_A0650 ENOG4106YXT transposase VC0395_A0651 ENOG4108WTW DNA transposition protein VC0395_A0661 ENOG41065S5 VC0395_A0672 ENOG4108Z6H mu-like prophage Flumu protein gp27 VC0395_A0673 ENOG4105CF2 Mu-like prophage FluMu protein GP28 VC0395_A0674 ENOG4105QIB mu-like prophage Flumu protein gp29 VC0395_A0682 ENOG4105EFV Major head subunit VC0395_A0684 ENOG4105Y5J prophage protein VC0395_A0688 ENOG4105TKZ Tail Sheath VC0395_A0690 ENOG41062PQ Mu-like prophage FluMu protein gp41 VC0395_A0694 ENOG4105PZ7 Baseplate assembly protein VC0395_A0696 ENOG4108T86 baseplate J family protein VC0395_A0697 ENOG41061A0 Mu-like prophage Flumu protein VC0395_A0701 ENOG4107S6Z Na H antiporter VC0395_A0702 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) VC0395_A0703 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) VC0395_A0704 ENOG4105CIH Imidazole acetol-phosphate transaminase VC0395_A0705 ENOG4105ECC imidazole-glycerol-phosphate dehydratase VC0395_A0706 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) VC0395_A0707 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase VC0395_A0708 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) VC0395_A0709 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase VC0395_A0710 ENOG4108R99 pseudouridine synthase VC0395_A0712 ENOG4105VEQ Cold shock protein VC0395_A0713 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) VC0395_A0714 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VC0395_A0716 ENOG41090BQ Glutaredoxin VC0395_A0717 ENOG4108EKI Dehydrogenase VC0395_A0718 ENOG4106KNT transcriptional regulator VC0395_A0719 ENOG4105DY8 decarboxylase VC0395_A0721 ENOG4105DWU Membrane VC0395_A0726 ENOG4105CUX Signal transduction histidine kinase VC0395_A0728 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) VC0395_A0731 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VC0395_A0732 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) VC0395_A0733 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) VC0395_A0734 ENOG41081XQ Conserved Protein VC0395_A0735 ENOG4105C9M aspartyl-trna synthetase VC0395_A0736 ENOG4107104 thymidine kinase VC0395_A0740 ENOG41061A0 Mu-like prophage Flumu protein VC0395_A0741 ENOG4108T86 baseplate J family protein VC0395_A0743 ENOG4105PZ7 Baseplate assembly protein VC0395_A0747 ENOG41062PQ Mu-like prophage FluMu protein gp41 VC0395_A0749 ENOG4105TKZ Tail Sheath VC0395_A0753 ENOG4105Y5J prophage protein VC0395_A0755 ENOG4105EFV Major head subunit VC0395_A0763 ENOG4105QIB mu-like prophage Flumu protein gp29 VC0395_A0764 ENOG4105CF2 Mu-like prophage FluMu protein GP28 VC0395_A0765 ENOG4108Z6H mu-like prophage Flumu protein gp27 VC0395_A0776 ENOG41065S5 VC0395_A0786 ENOG4108WTW DNA transposition protein VC0395_A0787 ENOG4106YXT transposase VC0395_A0788 ENOG4105R8V Transcriptional regulator VC0395_A0790 ENOG4105CK2 sodium dicarboxylate symporter VC0395_A0791 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) VC0395_A0792 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) VC0395_A0793 ENOG4105DK0 Indole-3-glycerol phosphate synthase VC0395_A0794 ENOG4108I0Q anthranilate phosphoribosyltransferase VC0395_A0795 ENOG4105DDQ anthranilate synthase VC0395_A0796 ENOG4105CRQ synthase (Component I) VC0395_A0798 ENOG4105DB7 PHP domain protein VC0395_A0799 ENOG4107RTD sua5 ycio yrdc ywlc family protein VC0395_A0800 ENOG4105FE9 pseudouridine synthase VC0395_A0801 ENOG4108JJ8 (ABC) transporter VC0395_A0802 ENOG4108JJ9 ABC, transporter VC0395_A0803 ENOG4105C3M thioredoxin reductase VC0395_A0805 ENOG4105C9B Cysteine desulfurase VC0395_A0806 ENOG4105BZU Histidine kinase VC0395_A0807 ENOG4107GZ4 SanA protein VC0395_A0809 ENOG4107R1I NAD-dependent malic enzyme VC0395_A0811 ENOG4105C8V SAICAR synthetase VC0395_A0815 ENOG4108ZG0 Ompa motb domain protein VC0395_A0818 ENOG4105CQB FAD linked oxidase domain protein VC0395_A0820 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap VC0395_A0822 ENOG4105C84 Histidine ammonia-lyase VC0395_A0823 ENOG4105CGP Urocanate hydratase VC0395_A0824 ENOG41088SP formiminoglutamate hydrolase VC0395_A0825 ENOG4105CI2 imidazolone-5-propionate hydrolase VC0395_A0826 ENOG4105CZE histidine utilization repressor VC0395_A0829 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VC0395_A0831 ENOG4105CQ2 DNA polymerase VC0395_A0832 ENOG4105BZU Histidine kinase VC0395_A0833 ENOG4105WH1 Two component transcriptional regulator luxr family VC0395_A0834 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) VC0395_A0841 ENOG4105BZU Histidine kinase VC0395_A0843 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) VC0395_A0844 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) VC0395_A0846 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VC0395_A0849 ENOG4105FQ6 thiopurine methyltransferase VC0395_A0852 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) VC0395_A0853 ENOG41067MG lrgb family VC0395_A0855 ENOG4105CJB Exodeoxyribonuclease I VC0395_A0856 ENOG4108ETY sodium dicarboxylate symporter VC0395_A0857 ENOG4105E0X reductase VC0395_A0859 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) VC0395_A0860 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) VC0395_A0861 ENOG4108YZT Adenosylcobinamide kinase VC0395_A0864 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) VC0395_A0865 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) VC0395_A0868 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A0873 ENOG4107QK7 reductase VC0395_A0874 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VC0395_A0875 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VC0395_A0876 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) VC0395_A0877 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VC0395_A0878 ENOG4105C72 UPF0176 protein VC0395_A0880 ENOG4105S8Q sugar efflux transporter VC0395_A0882 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) VC0395_A0888 ENOG4105EAQ (twin-arginine translocation) pathway signal VC0395_A0890 ENOG4105C5X domain protein VC0395_A0892 ENOG4105CH5 extracellular solute-binding protein, family 7 VC0395_A0894 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VC0395_A0897 ENOG41067TZ transcriptional regulator, MarR family VC0395_A0898 ENOG4105C94 Transporter VC0395_A0900 ENOG4105VZJ PTS System VC0395_A0902 ENOG4105VCP PTS System VC0395_A0903 ENOG4105F8D glycoside hydrolase family 4 VC0395_A0904 ENOG410901P UPF0249 protein VC0395_A0905 ENOG41060NJ transcriptional regulator VC0395_A0906 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) VC0395_A0907 ENOG4105DJ9 glucan biosynthesis protein VC0395_A0908 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A0911 ENOG4105CGF Aromatic amino acid aminotransferase VC0395_A0913 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VC0395_A0914 ENOG4105DWF phosphomethylpyrimidine kinase VC0395_A0915 ENOG4105C5S asparaginyl-tRNA synthetase VC0395_A0916 ENOG4108NVR Methyl-accepting chemotaxis VC0395_A0917 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase VC0395_A0918 ENOG4105EJQ L-serine dehydratase VC0395_A0919 ENOG4105C44 Serine transporter VC0395_A0920 ENOG4105P8F nudix hydrolase VC0395_A0921 ENOG4105CRQ synthase (Component I) VC0395_A0924 ENOG4105CM6 amino acid regulated cytosolic protein VC0395_A0926 ENOG4108JU8 Transcriptional regulator VC0395_A0927 ENOG4105D9U N-acetyltransferase VC0395_A0930 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VC0395_A0931 ENOG4108NVR Methyl-accepting chemotaxis VC0395_A0932 ENOG4105C8P )-transporter VC0395_A0933 ENOG4105BZU Histidine kinase VC0395_A0934 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A0935 ENOG4108MJ5 VirK protein VC0395_A0936 ENOG4105RW8 MltA-interacting MipA family protein VC0395_A0937 ENOG4105EB3 Histidine kinase VC0395_A0938 ENOG4107EXC regulatoR VC0395_A0944 ENOG4105C2J ABC transporter VC0395_A0945 ENOG4107SDZ Galactoside transport system permease protein mglC VC0395_A0951 ENOG41073TP transcriptional regulator VC0395_A0952 ENOG4105CR4 methylisocitrate lyase VC0395_A0953 ENOG4105BZN citrate synthase VC0395_A0954 ENOG4108I0Z Aconitate hydratase VC0395_A0955 ENOG4105C7F AcnD-accessory protein PrpF VC0395_A0956 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VC0395_A0959 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) VC0395_A0960 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase VC0395_A0961 ENOG4105F1J Homogentisate 1,2-dioxygenase VC0395_A0963 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VC0395_A0964 ENOG4108RXX maleylacetoacetate isomerase VC0395_A0965 ENOG4105BZU Histidine kinase VC0395_A0967 ENOG4106TD9 Diguanylate cyclase VC0395_A0968 ENOG4105DR4 Methyltransferase VC0395_A0970 ENOG4108Z0T Part of a sulfur-relay system (By similarity) VC0395_A0971 ENOG4108MN8 Membrane VC0395_A0972 ENOG4105CDA abc transporter atp-binding protein VC0395_A0973 ENOG4105DRP amino acid AbC transporter VC0395_A0974 ENOG4105EZ7 amino acid ABC transporter VC0395_A0975 ENOG4107QXX ABC transporter VC0395_A0977 ENOG410667J hydrolase VC0395_A0978 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) VC0395_A0980 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) VC0395_A0983 ENOG4105BZU Histidine kinase VC0395_A0985 ENOG4105BZU Histidine kinase VC0395_A0986 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB VC0395_A0987 ENOG4105CFG Acts as a chaperone (By similarity) VC0395_A0991 ENOG4105BZU Histidine kinase VC0395_A0997 ENOG4105CQ7 ATP-dependent helicase VC0395_A0999 ENOG4105R8A Heat shock protein VC0395_A1000 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) VC0395_A1001 ENOG4105EJC lysr family transcriptional regulator VC0395_A1003 ENOG4105C0R drug resistance transporter emrb qaca subfamily VC0395_A1004 ENOG4105CVP deoxyribo-dipyrimidine photolyase VC0395_A1005 ENOG4105KPY Small multidrug resistance protein VC0395_A1006 ENOG4108NVR Methyl-accepting chemotaxis VC0395_A1007 ENOG4108VYJ response regulator receiver protein VC0395_A1009 ENOG4105CBS Chea signal transduction histidine kinase VC0395_A1010 ENOG4105CBS Chea signal transduction histidine kinase VC0395_A1011 ENOG4105BZU Histidine kinase VC0395_A1013 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VC0395_A1014 ENOG4108V3W Chemotaxis protein, CheW VC0395_A1015 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A1016 ENOG4108N3W hemolysin secretion protein VC0395_A1017 ENOG4107SDU Methyl-accepting chemotaxis VC0395_A1018 ENOG4105C1J atp-dependent rna helicase VC0395_A1020 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VC0395_A1021 ENOG4105CW7 secretion protein, HlyD family VC0395_A1022 ENOG4105C0R drug resistance transporter emrb qaca subfamily VC0395_A1023 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A1024 ENOG4105CTD carboxy-peptidase VC0395_A1025 ENOG4108WC9 type VI secretion system effector, hcp1 family VC0395_A1031 ENOG410829K Lysine exporter protein (Lyse ygga) VC0395_A1032 ENOG4105BZG amino acid carrier protein VC0395_A1035 ENOG4107RUE extracellular solute-binding protein family 1 VC0395_A1036 ENOG4107RUE extracellular solute-binding protein family 1 VC0395_A1037 ENOG4105D38 putrescine abc transporter VC0395_A1038 ENOG4105F38 ABC transporter, permease VC0395_A1039 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VC0395_A1043 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) VC0395_A1044 ENOG4105Q9Y Universal stress protein VC0395_A1045 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VC0395_A1048 ENOG4105C59 p-type ATPase VC0395_A1050 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) VC0395_A1053 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i VC0395_A1055 ENOG4105BZU Histidine kinase VC0395_A1059 ENOG4105EUK rtx toxin RtxA VC0395_A1060 ENOG4107927 Cholera enterotoxin, A subunit VC0395_A1061 ENOG4105MQ5 zona occludens toxin VC0395_A1067 ENOG41067QW Transcriptional regulator VC0395_A1070 ENOG41067QW Transcriptional regulator VC0395_A1089 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) VC0395_A1090 ENOG4105DAN ATP-dependent protease VC0395_A1091 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) VC0395_A1093 ENOG4105C5H ABC transporter VC0395_A1095 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) VC0395_A1097 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) VC0395_A1098 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) VC0395_A1099 ENOG4105C7I Dehydrogenase VC0395_A1100 ENOG4105C7I Dehydrogenase VC0395_A1102 ENOG4105CD8 aminopeptidase N VC0395_A1104 ENOG4105CN1 protease VC0395_A1105 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) VC0395_A1106 ENOG4108ZGC gaf domain protein VC0395_A1107 ENOG4105BZ1 (ABC) transporter VC0395_A1108 ENOG4105H2K paraquat-inducible protein a VC0395_A1109 ENOG4105DY2 Paraquat-inducible protein b VC0395_A1110 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VC0395_A1111 ENOG4105QNR S1 RNA binding domain protein VC0395_A1114 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VC0395_A1116 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) VC0395_A1119 ENOG4105QAX Iron-sulfur VC0395_A1120 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) VC0395_A1122 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VC0395_A1126 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VC0395_A1127 ENOG4105C5H ABC transporter VC0395_A1128 ENOG4105BZU Histidine kinase VC0395_A1129 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A1131 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component VC0395_A1132 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VC0395_A1133 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) VC0395_A1134 ENOG4105CVM Molybdenum cofactor synthesis domain protein VC0395_A1138 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) VC0395_A1139 ENOG4106IUH DTW domain containing protein VC0395_A1141 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A1142 ENOG4107TT5 NLP P60 protein VC0395_A1144 ENOG4105FGM Fructosamine kinase VC0395_A1146 ENOG4107QI1 Mate efflux family protein VC0395_A1150 ENOG41067XB TonB family VC0395_A1151 ENOG4109015 Biopolymer transport protein exbD tolR VC0395_A1156 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component VC0395_A1157 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component VC0395_A1158 ENOG4108IJ9 (ABC) transporter VC0395_A1159 ENOG4105E98 transcriptional regulator DeoR family VC0395_A1160 ENOG4107VXM glycerophosphoryl diester phosphodiesterase VC0395_A1161 ENOG4105XEP YhcH YjgK YiaL family protein VC0395_A1162 ENOG4105M4H endoribonuclease L-psp VC0395_A1164 ENOG4105DDV Transcriptional regulator (LacI family VC0395_A1165 ENOG4105CS2 ec 3.2.1.21 VC0395_A1166 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) VC0395_A1169 ENOG4107QZV Type I secretion membrane fusion protein VC0395_A1171 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VC0395_A1172 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VC0395_A1173 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VC0395_A1174 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VC0395_A1175 ENOG4105C4M (Ubiquinol oxidase) subunit I VC0395_A1177 ENOG4105C9Q fumarate hydratase class II VC0395_A1180 ENOG4105V0I UPF0267 protein VC0395_A1182 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) VC0395_A1183 ENOG4105DUM transcriptional regulator, lysR family VC0395_A1184 ENOG4108TWJ NADH dehydrogenase subunit 5 VC0395_A1186 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VC0395_A1188 ENOG4105CH6 catalase VC0395_A1191 ENOG4107FQX Alpha-acetolactate decarboxylase VC0395_A1192 ENOG4105C7K acetolactate synthase VC0395_A1194 ENOG4105BZU Histidine kinase VC0395_A1195 ENOG4106TD9 Diguanylate cyclase VC0395_A1196 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) VC0395_A1197 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) VC0395_A1198 ENOG4105F0Z galactose-1-phosphate uridylyltransferase VC0395_A1204 ENOG4105BZU Histidine kinase VC0395_A1207 ENOG4107R88 Chemotaxis protein (CheV) VC0395_A1209 ENOG4106YYS transcriptional regulatory protein VC0395_A1210 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VC0395_A1212 ENOG4107V40 secretion protein, HlyD family VC0395_A1216 ENOG4105CVG Homoserine O-transsuccinylase VC0395_A1217 ENOG41090FY type IV pilus biogenesis stability protein PilW VC0395_A1219 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) VC0395_A1220 ENOG4108RS6 transposase VC0395_A1221 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) VC0395_A1222 ENOG4108VKG metal-dependent hydrolase VC0395_A1224 ENOG4105F04 LysR family Transcriptional regulator VC0395_A1228 ENOG4105DFG type I secretion outer membrane protein VC0395_A1229 ENOG4105CDV Ompa motb domain protein VC0395_A1230 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) VC0395_A1231 ENOG4105E3Q saccharopine dehydrogenase VC0395_A1233 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VC0395_A1236 ENOG4108I0Y (ABC) transporter VC0395_A1237 ENOG4105UQX Mate efflux family protein VC0395_A1238 ENOG4105CGD Nad-dependent epimerase dehydratase VC0395_A1240 ENOG4105C2C drug resistance transporter, Bcr CflA VC0395_A1241 ENOG4105I08 Pseudouridine synthase VC0395_A1242 ENOG4105CFI type iii restriction protein res subunit VC0395_A1246 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) VC0395_A1249 ENOG4108N3W hemolysin secretion protein VC0395_A1255 ENOG4105KXC Collagenase VC0395_A1256 ENOG4105KXC Collagenase VC0395_A1258 ENOG4105BZU Histidine kinase VC0395_A1259 ENOG4105BZU Histidine kinase VC0395_A1260 ENOG4105CJW magnesium transporter VC0395_A1262 ENOG4105C44 Serine transporter VC0395_A1264 ENOG4105CJ1 ABC, transporter VC0395_A1265 ENOG4107QWP ABC-2 type transporter VC0395_A1267 ENOG4105XZD Fe-S protein VC0395_A1269 ENOG4105VNH ABC transporter solute-binding protein VC0395_A1270 ENOG4105CXZ ABC transporter, permease VC0395_A1271 ENOG4108VGW abc transporter atp-binding protein VC0395_A1272 ENOG4108T9J Cdp-alcohol phosphatidyltransferase VC0395_A1273 ENOG4108W1A pseudouridine synthase VC0395_A1274 ENOG4105C8J )-transporter VC0395_A1275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) VC0395_A1276 ENOG4105C28 cystathionine VC0395_A1277 ENOG4108R3E Dna-3-methyladenine glycosylase i VC0395_A1280 ENOG4105C1P efflux transporter, rnd family, mfp subunit VC0395_A1283 ENOG41087YS Phage shock protein A VC0395_A1284 ENOG4105E51 psp operon transcriptional activator VC0395_A1285 ENOG4105DEF Extracellular solute-binding protein, family 5 VC0395_A1286 ENOG4108I5W peptide transport system, permease protein VC0395_A1287 ENOG4108EU3 peptide transport system, permease VC0395_A1288 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein VC0395_A1289 ENOG4108JQ2 peptide transport system atp-binding protein VC0395_A1292 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase VC0395_A1296 ENOG4107QY8 reductase VC0395_A1299 ENOG4105TMB Formate nitrite transporter VC0395_A1301 ENOG4108535 NAD dependent epimerase/dehydratase family VC0395_A1302 ENOG4105GFG DUF218 domain VC0395_A1304 ENOG4107835 probably involved in intracellular septation (By similarity) VC0395_A1305 ENOG4105NAU thioesterase Superfamily protein VC0395_A1306 ENOG4105K9H YciI-like protein VC0395_A1308 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) VC0395_A1309 ENOG4105DZ2 Transcriptional regulator VC0395_A1314 ENOG4105CCT upf0313 protein VC0395_A1317 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) VC0395_A1318 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) VC0395_A1319 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) VC0395_A1320 ENOG4106371 Methyltransferase VC0395_A1321 ENOG4107S90 membrAne VC0395_A1322 ENOG4106WF9 DNA-binding transcriptional regulator TorR VC0395_A1323 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VC0395_A1324 ENOG4105ETE Transcriptional regulator (LacI family VC0395_A1325 ENOG4105HP8 regulator of competence-specific genes VC0395_A1329 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) VC0395_A1330 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) VC0395_A1332 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VC0395_A1333 ENOG4105RKX Protein of unknown function (DUF2498) VC0395_A1334 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase VC0395_A1336 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) VC0395_A1337 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate VC0395_A1338 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) VC0395_A1340 ENOG4107QPN acyl-Coa dehydrogenase VC0395_A1341 ENOG41067SE Tetr family transcriptional regulator VC0395_A1344 ENOG4105C26 Dehydrogenase VC0395_A1345 ENOG4105MTM Protein of unknown function (DUF1496) VC0395_A1346 ENOG4108R86 Transcriptional regulator VC0395_A1351 ENOG4105F1S paraquat-inducible protein a VC0395_A1352 ENOG4105DY2 Paraquat-inducible protein b VC0395_A1357 ENOG4105DFP Integrase VC0395_A1358 ENOG4105DFP Integrase VC0395_A1359 ENOG4105C0D helicase VC0395_A1363 ENOG4105DZR Type I site-specific deoxyribonuclease VC0395_A1367 ENOG4105CVR type I restriction-modification system VC0395_A1371 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) VC0395_A1372 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) VC0395_A1373 ENOG4105QEK Transcriptional regulator VC0395_A1375 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VC0395_A1376 ENOG41069H7 transport system small permease component VC0395_A1377 ENOG4108ERU trap dicarboxylate transporter subunit DctP VC0395_A1378 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) VC0395_A1379 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) VC0395_A1380 ENOG4105CE4 GlcNAc 6-P deacetylase VC0395_A1381 ENOG4108478 ec 3.2.1.18 VC0395_A1383 ENOG4108YGG dna repair protein VC0395_A1388 ENOG4108NYK Tape measure protein VC0395_A1410 ENOG4105CVP deoxyribo-dipyrimidine photolyase VC0395_A1412 ENOG4105VYA Uncharacterized conserved protein (DUF2132) VC0395_A1413 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VC0395_A1414 ENOG4105C26 Dehydrogenase VC0395_A1416 ENOG4105DM4 PTS System VC0395_A1417 ENOG4105DM4 PTS System VC0395_A1418 ENOG4108YRF PTS System VC0395_A1419 ENOG4106R3P AraC family transcriptional regulator VC0395_A1421 ENOG4105DM4 PTS System VC0395_A1422 ENOG4105EIP mannose-6-phosphate isomerase VC0395_A1423 ENOG4108RNS Exports L-alanine (By similarity) VC0395_A1424 ENOG4105BZU Histidine kinase VC0395_A1426 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) VC0395_A1428 ENOG4105KCK Peptidoglycan-associated lipoprotein VC0395_A1429 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) VC0395_A1431 ENOG4105M8F Biopolymer transport protein exbD tolR VC0395_A1432 ENOG4105E02 MotA TolQ exbB proton channel VC0395_A1434 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VC0395_A1435 ENOG4105C4M (Ubiquinol oxidase) subunit I VC0395_A1436 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) VC0395_A1437 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) VC0395_A1438 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) VC0395_A1439 ENOG4105C8N cysteinyl-tRNA synthetase VC0395_A1440 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VC0395_A1441 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) VC0395_A1442 ENOG4105D58 Diguanylate phosphodiesterase VC0395_A1445 ENOG4105ZU8 porin-like protein H VC0395_A1446 ENOG4105DVT helicase VC0395_A1447 ENOG4105EJ9 Membrane VC0395_A1448 ENOG4108URS primosomal replication protein n'' VC0395_A1449 ENOG4106428 Protein of unknown function (DUF2496) VC0395_A1450 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A1451 ENOG4105CGK Exodeoxyribonuclease III VC0395_A1452 ENOG4106YG3 ABC transporter VC0395_A1453 ENOG4105DSP amino acid AbC transporter VC0395_A1454 ENOG4105E89 ABC transporter VC0395_A1455 ENOG4108JEH abc transporter atp-binding protein VC0395_A1457 ENOG4105C6N Formate acetyltransferase VC0395_A1459 ENOG4108N3W hemolysin secretion protein VC0395_A1460 ENOG4105F1A Pyruvate formate-lyase VC0395_A1462 ENOG4105XWI UPF0304 protein VC0395_A1463 ENOG4105CYN Serine protein kinase VC0395_A1464 ENOG4106AKX UPF0229 protein VC0395_A1465 ENOG4105ED1 spovr family VC0395_A1466 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) VC0395_A1468 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) VC0395_A1469 ENOG4105BZ1 (ABC) transporter VC0395_A1470 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 VC0395_A1472 ENOG4105D60 lipoprotein releasing system transmembrane protein VC0395_A1473 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VC0395_A1474 ENOG4105D60 lipoprotein releasing system transmembrane protein VC0395_A1476 ENOG4108JA2 transcriptioN-repair coupling factor VC0395_A1478 ENOG4106M3D hemolysin VC0395_A1480 ENOG4105CEP NADH dehydrogenase VC0395_A1487 ENOG4105K59 histidine triad (HIT) protein VC0395_A1488 ENOG4108NVR Methyl-accepting chemotaxis VC0395_A1490 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) VC0395_A1491 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) VC0395_A1492 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) VC0395_A1493 ENOG4105CNU cell division protein FtsK VC0395_A1494 ENOG4105EW9 transcriptional regulator AsnC family VC0395_A1495 ENOG4105DCF alanine dehydrogenase VC0395_A1497 ENOG4107R11 Transcriptional regulator VC0395_A1500 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase VC0395_A1501 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) VC0395_A1502 ENOG4105CFV Tetratricopeptide repeat protein VC0395_A1503 ENOG4105Q4A inner membrane protein yciS VC0395_A1504 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) VC0395_A1505 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) VC0395_A1506 ENOG4105CAT Cytidine monophosphate kinase VC0395_A1507 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein VC0395_A1508 ENOG4105EIN peptidylprolyl cis-trans isomerase VC0395_A1509 ENOG4105K70 DNA-binding protein VC0395_A1510 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VC0395_A1511 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) VC0395_A1512 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VC0395_A1513 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation VC0395_A1516 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A1517 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VC0395_A1518 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ VC0395_A1519 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VC0395_A1520 ENOG4105CNG UPF0061 protein VC0395_A1523 ENOG4105BZU Histidine kinase VC0395_A1525 ENOG4108HPI phosphatidate Cytidylyltransferase VC0395_A1533 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) VC0395_A1536 ENOG4105JQN Transcriptional regulator VC0395_A1538 ENOG4107QY8 reductase VC0395_A1539 ENOG4105CUW cytochrome C-TYPE protein VC0395_A1540 ENOG410662T chitinase VC0395_A1541 ENOG4105D9N nucleoside VC0395_A1542 ENOG4105JQN Transcriptional regulator VC0395_A1543 ENOG4105CVE Lytic murein transglycosylase VC0395_A1544 ENOG4105VNG YcgL domain-containing protein VC0395_A1545 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) VC0395_A1546 ENOG4107QMS site-determining protein VC0395_A1547 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) VC0395_A1552 ENOG4107S74 Lysophospholipid transporter LplT VC0395_A1554 ENOG4108N3W hemolysin secretion protein VC0395_A1555 ENOG4108JCI Transcriptional regulator VC0395_A1556 ENOG4105DKK Benzoate VC0395_A1557 ENOG4105CEY Amp-dependent synthetase and ligase VC0395_A1558 ENOG4105DNI Converts SHCHC to OSB (By similarity) VC0395_A1559 ENOG4108IPT Naphthoate synthase VC0395_A1560 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) VC0395_A1561 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) VC0395_A1562 ENOG4105E4F Isochorismate synthase VC0395_A1563 ENOG4105CHM Aminotransferase VC0395_A1564 ENOG4105DK2 UPF0207 protein VC0395_A1566 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein VC0395_A1569 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) VC0395_A1570 ENOG4105CEY Amp-dependent synthetase and ligase VC0395_A1571 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VC0395_A1574 ENOG41072GX Peptidase M22 Glycoprotease VC0395_A1575 ENOG4105DVT helicase VC0395_A1577 ENOG4105CIY formyltetrahydrofolate deformylase VC0395_A1578 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VC0395_A1579 ENOG4105D07 Signal peptide peptidase, SppA VC0395_A1580 ENOG4105HDK L-asparaginase VC0395_A1581 ENOG4105VUT cytoplasmic protein VC0395_A1584 ENOG4105E0X reductase VC0395_A1586 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VC0395_A1587 ENOG4105DSB aldose 1-epimerase VC0395_A1589 ENOG4105DHI Methyltransferase VC0395_A1592 ENOG4107R88 Chemotaxis protein (CheV) VC0395_A1593 ENOG4105DAG ROK family VC0395_A1594 ENOG4105CA9 Pyruvate kinase VC0395_A1595 ENOG4108NRW Phospholipase, patatin family VC0395_A1598 ENOG4105C8J )-transporter VC0395_A1599 ENOG4105CI1 PTS System VC0395_A1600 ENOG4105F8V Hydrolase, tatD family VC0395_A1601 ENOG4107QRG dna polymerase iii VC0395_A1602 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) VC0395_A1603 ENOG4105HHA aminodeoxychorismate lyase VC0395_A1604 ENOG4105YAZ 4-amino-4-deoxychorismate lyase VC0395_A1605 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VC0395_A1606 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VC0395_A1607 ENOG4105CHR reductase VC0395_A1608 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase VC0395_A1609 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) VC0395_A1610 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) VC0395_A1611 ENOG4105VGS 50s ribosomal protein l32 VC0395_A1612 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein VC0395_A1613 ENOG4108UHJ MAF-like protein VC0395_A1614 ENOG4105EI2 Pseudouridine synthase VC0395_A1615 ENOG4105C03 ribonuclease VC0395_A1617 ENOG4105CHH sulfate transporter VC0395_A1619 ENOG4108EKI Dehydrogenase VC0395_A1620 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein VC0395_A1621 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VC0395_A1622 ENOG4105DFD Na H antiporter VC0395_A1624 ENOG4106V8H Nucleoid-associated protein VC0395_A1626 ENOG4105E68 Sulfatase VC0395_A1629 ENOG4105DGU Histone deacetylase VC0395_A1630 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VC0395_A1631 ENOG4105M2J Glutaredoxin VC0395_A1632 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VC0395_A1636 ENOG410903C (LipO)protein VC0395_A1638 ENOG4105KWW Biogenesis protein VC0395_A1639 ENOG4107QX9 Thiol disulfide interChange protein VC0395_A1640 ENOG4105DA4 cytochrome c-type biogenesis protein VC0395_A1641 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) VC0395_A1642 ENOG41067VX Heme exporter protein VC0395_A1643 ENOG41060IM Heme exporter protein VC0395_A1644 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) VC0395_A1645 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) VC0395_A1647 ENOG4108V3W Chemotaxis protein, CheW VC0395_A1649 ENOG4107QJE Chromosome Partitioning Protein VC0395_A1650 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) VC0395_A1651 ENOG4105CBS Chea signal transduction histidine kinase VC0395_A1652 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) VC0395_A1653 ENOG4108VYJ response regulator receiver protein VC0395_A1654 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VC0395_A1655 ENOG4107R21 site-determining protein VC0395_A1656 ENOG4105FZW flagellar biosynthesis regulator FlhF VC0395_A1657 ENOG4105D7B Flagellar biosynthesis protein flha VC0395_A1658 ENOG4108BY2 phosphohistidine phosphatase VC0395_A1660 ENOG4108JQM Insulinase (Peptidase family M16) VC0395_A1661 ENOG4105C75 arginyL-tRNA synthetase VC0395_A1665 ENOG4105XFK Ferrous iron transport protein A VC0395_A1666 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) VC0395_A1667 ENOG4105NXV High-affinity zinc uptake system protein VC0395_A1668 ENOG4105FDK ABC transporter VC0395_A1669 ENOG4105FAV ABC, transporter VC0395_A1670 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha VC0395_A1671 ENOG4105CMV Succinyl-CoA synthetase subunit beta VC0395_A1672 ENOG4105C7S Dehydrogenase VC0395_A1673 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 VC0395_A1674 ENOG4105E33 succinate dehydrogenase VC0395_A1675 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VC0395_A1676 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein VC0395_A1677 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit VC0395_A1678 ENOG4105BZN citrate synthase VC0395_A1679 ENOG4107QNR UPF0135 protein VC0395_A1681 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 VC0395_A1682 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) VC0395_A1683 ENOG4105EV9 Alpha Beta Hydrolase VC0395_A1685 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) VC0395_A1686 ENOG41067MG lrgb family VC0395_A1687 ENOG4105VAW lrga family VC0395_A1688 ENOG4105CMU LysR family (Transcriptional regulator VC0395_A1690 ENOG41090R7 Ferric uptake VC0395_A1691 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VC0395_A1692 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) VC0395_A1693 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VC0395_A1694 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) VC0395_A1695 ENOG4105Q8W reductase VC0395_A1696 ENOG4105MH2 YfcL protein VC0395_A1697 ENOG4108BPE -transporting atpase VC0395_A1698 ENOG4105EN6 Membrane VC0395_A1699 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase VC0395_A1700 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) VC0395_A1702 ENOG4105D00 flagellar biosynthetic protein flhB VC0395_A1703 ENOG4105D19 Role in flagellar biosynthesis (By similarity) VC0395_A1704 ENOG4105VS8 Flagellar biosynthetic protein fliq VC0395_A1705 ENOG4105CN7 Flagellar biosynthetic protein FliP VC0395_A1706 ENOG4105VTB flagellar biosynthesis protein fliO VC0395_A1708 ENOG4105DD5 Flagellar motor switch protein VC0395_A1709 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VC0395_A1710 ENOG4105X6C Flagellar basal body-associated protein FliL VC0395_A1714 ENOG4108JIR Flagellum-specific ATP synthase VC0395_A1715 ENOG4105W2B Flagellar assembly protein VC0395_A1716 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VC0395_A1717 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) VC0395_A1718 ENOG4105VQ0 flagellar hook-basal body complex protein fliE VC0395_A1719 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A1720 ENOG4105BZU Histidine kinase VC0395_A1721 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A1722 ENOG4105MQ3 flagellar protein FliS VC0395_A1724 ENOG4107W9T flagellar hook-associated VC0395_A1725 ENOG41063QE flagellar protein FlaG VC0395_A1726 ENOG4105I03 Flagellin VC0395_A1727 ENOG4105I03 Flagellin VC0395_A1728 ENOG4105I03 Flagellin VC0395_A1729 ENOG4105EZR dyp-type peroxidase family protein VC0395_A1730 ENOG4105QZU Inner membrane protein YfeZ VC0395_A1733 ENOG4105KUZ arsenate reductase VC0395_A1734 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) VC0395_A1737 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VC0395_A1738 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) VC0395_A1740 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VC0395_A1741 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A1744 ENOG4105ERG peptidase m48, ste24p VC0395_A1745 ENOG4105K89 arsenate reductase VC0395_A1746 ENOG4105CS1 NAD(P)H quinone oxidoreductase VC0395_A1749 ENOG4105C2W permease VC0395_A1750 ENOG4108Z66 YbaK ebsC protein VC0395_A1751 ENOG4105CGH 5'-nucleotidase VC0395_A1752 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase VC0395_A1753 ENOG41063JG Transcriptional regulator VC0395_A1754 ENOG4108YY7 Invasion gene expression up-regulator SirB VC0395_A1755 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) VC0395_A1756 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) VC0395_A1757 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) VC0395_A1758 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) VC0395_A1759 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) VC0395_A1760 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VC0395_A1761 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) VC0395_A1762 ENOG4105C3G gtp-binding protein VC0395_A1777 ENOG4108RS6 transposase VC0395_A1779 ENOG4105I03 Flagellin VC0395_A1780 ENOG4105I03 Flagellin VC0395_A1784 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj VC0395_A1785 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VC0395_A1786 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) VC0395_A1787 ENOG4105CGA flagellar basal-body rod protein FlgG VC0395_A1788 ENOG4108KPB Flagellar basal-body rod protein FlgF VC0395_A1789 ENOG4105BZE flagellar hook protein, FlgE VC0395_A1790 ENOG4105W00 Flagellar hook capping protein VC0395_A1791 ENOG4108ZC9 flagellar basal-body rod protein flgc VC0395_A1792 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) VC0395_A1793 ENOG4105BZU Histidine kinase VC0395_A1794 ENOG4107R88 Chemotaxis protein (CheV) VC0395_A1801 ENOG4105C0W non-ribosomal peptide synthetase VC0395_A1802 ENOG4105Q26 Siderophore-interacting protein VC0395_A1803 ENOG4107RBR Receptor VC0395_A1805 ENOG4105UYK outer membrane protein a VC0395_A1806 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) VC0395_A1807 ENOG4105C59 p-type ATPase VC0395_A1809 ENOG4105E2D ec 3.2.1.52 VC0395_A1812 ENOG4105MBR gumn family VC0395_A1815 ENOG4108DG9 Smr protein MutS2 VC0395_A1816 ENOG4105FE9 pseudouridine synthase VC0395_A1817 ENOG4105BZU Histidine kinase VC0395_A1818 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) VC0395_A1819 ENOG4105CXB phosphoribosylaminoimidazole synthetase VC0395_A1820 ENOG4108V3E phosphoribosylglycinamide formyltransferase VC0395_A1821 ENOG4105E7A Glutamine amidotransferase VC0395_A1822 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) VC0395_A1823 ENOG4107QPN acyl-Coa dehydrogenase VC0395_A1825 ENOG4108JDX DNA polymerase iii, epsilon subunit VC0395_A1826 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VC0395_A1827 ENOG4105D1A Methyltransferase VC0395_A1828 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) VC0395_A1829 ENOG4105E9H Lytic Murein transglycosylase VC0395_A1831 ENOG4108YZA Nitrogen regulatory protein pii VC0395_A1832 ENOG4105PY6 Phenolic acid decarboxylase VC0395_A1833 ENOG4105N7H Cytochrome VC0395_A1834 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) VC0395_A1835 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) VC0395_A1836 ENOG4105C0B DNA polymerase III (alpha subunit) VC0395_A1837 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) VC0395_A1838 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VC0395_A1839 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VC0395_A1840 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) VC0395_A1841 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VC0395_A1842 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) VC0395_A1844 ENOG4105DZP Membrane-associated zinc metalloprotease VC0395_A1845 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) VC0395_A1846 ENOG4105KNE Phosphatidate cytidylyltransferase VC0395_A1847 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) VC0395_A1848 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) VC0395_A1849 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) VC0395_A1850 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) VC0395_A1851 ENOG4105CE9 30S ribosomal protein S2 VC0395_A1852 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) VC0395_A1853 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) VC0395_A1854 ENOG4108T8E UPF0325 protein VC0395_A1855 ENOG4108ZAI phosphatidylglycerophosphatase a VC0395_A1856 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) VC0395_A1857 ENOG4107YIM Involved in the transcription termination process (By similarity) VC0395_A1858 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) VC0395_A1861 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VC0395_A1862 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) VC0395_A1863 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) VC0395_A1864 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) VC0395_A1865 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) VC0395_A1867 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) VC0395_A1868 ENOG4105C7N Xanthine uracil vitamin C permease VC0395_A1869 ENOG4105CIN aminoacyl-histidine dipeptidase VC0395_A1870 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VC0395_A1871 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VC0395_A1873 ENOG4105C8J )-transporter VC0395_A1874 ENOG4105BZU Histidine kinase VC0395_A1876 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VC0395_A1878 ENOG4105CJ2 (LipO)protein VC0395_A1879 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) VC0395_A1880 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VC0395_A1881 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VC0395_A1882 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VC0395_A1883 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VC0395_A1884 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) VC0395_A1885 ENOG4105M85 Bola protein VC0395_A1886 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VC0395_A1888 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VC0395_A1889 ENOG4105EYM Major Facilitator superfamily VC0395_A1891 ENOG4105K6V RNA polymerase VC0395_A1893 ENOG4105DRB nucleoside-specific channel-forming protein VC0395_A1894 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VC0395_A1895 ENOG4107S0N DJ-1 family VC0395_A1896 ENOG4105C9B Cysteine desulfurase VC0395_A1897 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) VC0395_A1898 ENOG4105CUZ uba thif-type nad fad binding protein VC0395_A1899 ENOG4105CA3 membrane-bound lytic murein transglycosylase VC0395_A1901 ENOG4107QZM n-acetylglutamate synthase VC0395_A1903 ENOG4107QYX exodeoxyribonuclease v alpha VC0395_A1904 ENOG4107QKA exodeoxyribonuclease V beta VC0395_A1905 ENOG4105DSY exodeoxyribonuclease V, gamma VC0395_A1908 ENOG4105X2V dna damage-inducible protein VC0395_A1909 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) VC0395_A1911 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) VC0395_A1912 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) VC0395_A1914 ENOG4108Y51 tRNA-binding protein VC0395_A1917 ENOG4105CNT hydrolase family 2 VC0395_A1919 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VC0395_A1920 ENOG4108IQE Amp-dependent synthetase and ligase VC0395_A1921 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VC0395_A1922 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) VC0395_A1924 ENOG4105EAC phosphoserine phosphatase VC0395_A1926 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VC0395_A1927 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) VC0395_A1928 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) VC0395_A1929 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) VC0395_A1931 ENOG4105D9N nucleoside VC0395_A1932 ENOG4105EYA deoxyribonuclease VC0395_A1935 ENOG4105BZG amino acid carrier protein VC0395_A1938 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) VC0395_A1939 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) VC0395_A1940 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) VC0395_A1941 ENOG4105D98 threonine synthase VC0395_A1942 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) VC0395_A1944 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VC0395_A1947 ENOG41065U4 response regulator VC0395_A1948 ENOG4105BZU Histidine kinase VC0395_A1950 ENOG4105N5T Radical SAM Protein VC0395_A1954 ENOG4105CBC glutamate synthase VC0395_A1955 ENOG4105BZ8 glutamate synthase VC0395_A1957 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) VC0395_A1959 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) VC0395_A1960 ENOG4105EN6 Membrane VC0395_A1961 ENOG4105EJ9 Membrane VC0395_A1962 ENOG4107RRE RNA-directed DNA polymerase VC0395_A1967 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain VC0395_A1968 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain VC0395_A1970 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) VC0395_A1971 ENOG4105M6F mutator MutT protein VC0395_A1972 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving VC0395_A1974 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VC0395_A1975 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) VC0395_A1976 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) VC0395_A1977 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) VC0395_A1978 ENOG4105DFU Cell wall formation (By similarity) VC0395_A1979 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) VC0395_A1981 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) VC0395_A1982 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) VC0395_A1983 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) VC0395_A1984 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) VC0395_A1985 ENOG4105CJN penicillin-binding protein VC0395_A1986 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VC0395_A1987 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) VC0395_A1988 ENOG4107QN2 dihydrolipoyl dehydrogenase VC0395_A1989 ENOG4107QSN dihydrolipoamide acetyltransferase VC0395_A1990 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) VC0395_A1991 ENOG41073TP transcriptional regulator VC0395_A1992 ENOG4105CGH 5'-nucleotidase VC0395_A1993 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) VC0395_A1994 ENOG4105T95 Thiol disulfide interChange protein VC0395_A1995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VC0395_A1996 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) VC0395_A1998 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase VC0395_A2000 ENOG4107QHF type ii secretion system protein e VC0395_A2001 ENOG4105D7Q type ii secretion system VC0395_A2002 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) VC0395_A2003 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) VC0395_A2005 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) VC0395_A2006 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) VC0395_A2007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VC0395_A2008 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VC0395_A2009 ENOG4105IPS esterase VC0395_A2010 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VC0395_A2011 ENOG4108SX3 cytoplasmic protein VC0395_A2012 ENOG41087AY ADP-Ribose pyrophosphatase VC0395_A2013 ENOG4105DFG type I secretion outer membrane protein VC0395_A2014 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) VC0395_A2015 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) VC0395_A2016 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A2018 ENOG4105I7R Adenylate cyclase VC0395_A2019 ENOG4107IX6 phosphate transport regulator VC0395_A2020 ENOG4105CJ3 phosphate transporter VC0395_A2021 ENOG4106MWK domain protein VC0395_A2024 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate VC0395_A2025 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) VC0395_A2026 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) VC0395_A2028 ENOG4105DXN mazG family VC0395_A2029 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VC0395_A2030 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VC0395_A2032 ENOG4105BZU Histidine kinase VC0395_A2035 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) VC0395_A2036 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) VC0395_A2037 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) VC0395_A2038 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) VC0395_A2039 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) VC0395_A2040 ENOG4105C3F Signal peptidase i VC0395_A2041 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) VC0395_A2042 ENOG4105WMJ Positive regulator of sigma E, RseC MucC VC0395_A2043 ENOG4105VQK sigma E regulatory protein, MucB RseB VC0395_A2045 ENOG4105EMN RNA polymerase sigma factor VC0395_A2046 ENOG4108IYU L-aspartate oxidase VC0395_A2048 ENOG4105Y75 tpr repeat protein VC0395_A2049 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) VC0395_A2051 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VC0395_A2052 ENOG4105D0A hydroxylase VC0395_A2054 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) VC0395_A2055 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase VC0395_A2056 ENOG4105E66 phosphoriboisomerase A VC0395_A2057 ENOG4108JQ1 Dehydrogenase VC0395_A2058 ENOG4108ZP8 Acetolactate synthase small subunit VC0395_A2059 ENOG4105C7K acetolactate synthase VC0395_A2060 ENOG4108IQE Amp-dependent synthetase and ligase VC0395_A2061 ENOG41064T2 transcriptional regulator, lysR family VC0395_A2065 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) VC0395_A2066 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VC0395_A2067 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VC0395_A2068 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) VC0395_A2078 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase VC0395_A2081 ENOG4108K5H permease YjgP YjgQ family protein VC0395_A2082 ENOG4108M8S permease YjgP YjgQ family protein VC0395_A2083 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) VC0395_A2084 ENOG4105MYG DNA polymerase iii, chi subunit VC0395_A2085 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) VC0395_A2086 ENOG4105C5I Dehydrogenase VC0395_A2087 ENOG4105D3G Pseudouridine synthase VC0395_A2088 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) VC0395_A2090 ENOG4108IAB Phoh family VC0395_A2091 ENOG4105DBV ornithine carbamoyltransferase VC0395_A2092 ENOG4105CXT aspartate transcarbamylase VC0395_A2093 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) VC0395_A2094 ENOG4105KME endoribonuclease L-psp VC0395_A2095 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase VC0395_A2096 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) VC0395_A2097 ENOG4105VFK BolA family VC0395_A2099 ENOG4105E3I toluene tolerance VC0395_A2100 ENOG4107PE3 Mammalian cell entry related domain protein VC0395_A2101 ENOG4105CY3 ABC transporter, permease VC0395_A2102 ENOG4105DHJ ABC, transporter VC0395_A2104 ENOG4105C2X Arabinose 5-phosphate isomerase VC0395_A2105 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase VC0395_A2107 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA VC0395_A2108 ENOG4108IUZ ABC transporter VC0395_A2109 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VC0395_A2110 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA VC0395_A2111 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN VC0395_A2113 ENOG41080Z8 PHOSPHOCARRIER protein VC0395_A2114 ENOG4105CJW magnesium transporter VC0395_A2115 ENOG4105CMS peptidase U62, modulator of DNA gyrase VC0395_A2116 ENOG4105N42 UPF0307 protein VC0395_A2117 ENOG4107T0D ABC, transporter VC0395_A2118 ENOG4106SMU thiamine transporter membrane protein VC0395_A2119 ENOG4105DP9 ABC transporter VC0395_A2120 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase VC0395_A2121 ENOG4105DFU Cell wall formation (By similarity) VC0395_A2122 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 VC0395_A2123 ENOG4105F0N pyrophosphate phospho-hydrolase VC0395_A2124 ENOG41066HZ AIG2-like family VC0395_A2126 ENOG4105CFU surface antigen VC0395_A2127 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) VC0395_A2128 ENOG4108UUE Transcriptional regulator VC0395_A2131 ENOG4107R39 (ABC) transporter VC0395_A2135 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) VC0395_A2136 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) VC0395_A2137 ENOG4105C11 sulfate adenylyltransferase), subunit 2 VC0395_A2138 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) VC0395_A2139 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic VC0395_A2141 ENOG4105C1J atp-dependent rna helicase VC0395_A2142 ENOG4107YB6 acetyltransferase, (GNAT) family VC0395_A2143 ENOG4108SXK Transporter Drug Metabolite Exporter family VC0395_A2145 ENOG4108V1T peptidylprolyl cis-trans isomerase VC0395_A2146 ENOG4108RS6 transposase VC0395_A2148 ENOG4108ZT0 50S ribosomal protein l17 VC0395_A2149 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VC0395_A2150 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) VC0395_A2151 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) VC0395_A2152 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits VC0395_A2154 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) VC0395_A2155 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) VC0395_A2156 ENOG4105VPB 50S ribosomal protein L30 VC0395_A2157 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) VC0395_A2158 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) VC0395_A2159 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) VC0395_A2160 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) VC0395_A2161 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) VC0395_A2162 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits VC0395_A2163 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) VC0395_A2164 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) VC0395_A2165 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal VC0395_A2166 ENOG41083MP 50s ribosomal protein l29 VC0395_A2167 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) VC0395_A2168 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) VC0395_A2169 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) VC0395_A2170 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) VC0395_A2171 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity VC0395_A2172 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) VC0395_A2173 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) VC0395_A2174 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) VC0395_A2175 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) VC0395_A2176 ENOG4105C2N RNA methyltransferase TrmH family group 3 VC0395_A2177 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VC0395_A2178 ENOG4105E68 Sulfatase VC0395_A2179 ENOG4108UV7 flagellar protein motX VC0395_A2180 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis VC0395_A2181 ENOG4105D44 asparaginase VC0395_A2182 ENOG4108YZY peptidylprolyl cis-trans isomerase VC0395_A2185 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein VC0395_A2186 ENOG4105C5H ABC transporter VC0395_A2188 ENOG4105DNZ Alpha Beta Hydrolase VC0395_A2190 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) VC0395_A2191 ENOG4107RYR Transcriptional regulator, Crp Fnr family VC0395_A2193 ENOG4105C26 Dehydrogenase VC0395_A2195 ENOG4105C8Y Acetylornithine aminotransferase VC0395_A2196 ENOG4105DDQ anthranilate synthase VC0395_A2197 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) VC0395_A2200 ENOG4105C31 Tryptophanyl-tRNA synthetase VC0395_A2201 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VC0395_A2202 ENOG4105DJV ribulose-phosphate 3-epimerase VC0395_A2203 ENOG4105DFE Dna adenine methylase VC0395_A2205 ENOG4105D49 3-dehydroquinate synthase VC0395_A2206 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) VC0395_A2207 ENOG4105E4G Type IV pilus VC0395_A2212 ENOG4108JQC penicillin-binding protein 1A VC0395_A2214 ENOG4105EHV domain protein VC0395_A2215 ENOG4107QN2 dihydrolipoyl dehydrogenase VC0395_A2217 ENOG4105CH7 arginosuccinase VC0395_A2218 ENOG4105CDH Citrulline--aspartate ligase VC0395_A2219 ENOG4105CAS nag kinase VC0395_A2220 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase VC0395_A2221 ENOG4105CWC Acetylornithine deacetylase VC0395_A2222 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) VC0395_A2225 ENOG4105D7W serine acetyltransferase VC0395_A2226 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase VC0395_A2227 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) VC0395_A2228 ENOG4107YZP Rhodanese domain protein VC0395_A2229 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) VC0395_A2231 ENOG4105E33 succinate dehydrogenase VC0395_A2232 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VC0395_A2233 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) VC0395_A2234 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) VC0395_A2235 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein VC0395_A2237 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) VC0395_A2238 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) VC0395_A2243 ENOG4105CP7 Triose-phosphate isomerase VC0395_A2245 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) VC0395_A2246 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase VC0395_A2247 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) VC0395_A2248 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) VC0395_A2249 ENOG41063M6 Cell Division Protein VC0395_A2250 ENOG4105ETE Transcriptional regulator (LacI family VC0395_A2251 ENOG4105C25 Primosomal protein n' VC0395_A2252 ENOG4105VFB Binds the 23S rRNA (By similarity) VC0395_A2254 ENOG4105C6K Malic enzyme VC0395_A2255 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) VC0395_A2256 ENOG4105C28 cystathionine VC0395_A2257 ENOG4105CFH Aspartokinase VC0395_A2258 ENOG4105SYT Methylenetetrahydrofolate reductase VC0395_A2259 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) VC0395_A2260 ENOG4105CBT Fructose-1,6-bisphosphatase VC0395_A2261 ENOG4105CTQ phosphohexokinase VC0395_A2262 ENOG41076HS cation diffusion facilitator family transporter VC0395_A2264 ENOG4105E3W Two component transcriptional regulator (Winged helix family VC0395_A2265 ENOG4105E0F Histidine kinase VC0395_A2267 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) VC0395_A2268 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 VC0395_A2269 ENOG4105BZU Histidine kinase VC0395_A2270 ENOG4108IJ0 Aspartate ammonia-lyase VC0395_A2271 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VC0395_A2274 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) VC0395_A2276 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) VC0395_A2278 ENOG4107QN1 sodium solute VC0395_A2279 ENOG4105EX9 Membrane VC0395_A2280 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) VC0395_A2281 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) VC0395_A2282 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VC0395_A2283 ENOG4105CB5 ATP-dependent DNA helicase recG VC0395_A2284 ENOG4105C2W permease VC0395_A2285 ENOG4105E0F Histidine kinase VC0395_A2286 ENOG4105DPZ Two component transcriptional regulator (Winged helix family VC0395_A2287 ENOG4108RRZ Transcription elongation factor GreB VC0395_A2288 ENOG4105BZM domain protein VC0395_A2290 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) VC0395_A2292 ENOG4105MJ2 Competence protein VC0395_A2293 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) VC0395_A2294 ENOG4107RK2 ADP-ribose diphosphatase NudE VC0395_A2295 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase VC0395_A2296 ENOG4105PIC general secretion pathway protein N VC0395_A2297 ENOG4105U1E general secretion pathway protein M VC0395_A2298 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) VC0395_A2299 ENOG4108RTD type II secretion system protein K VC0395_A2300 ENOG4108WWZ General secretion pathway protein J VC0395_A2301 ENOG4105X5Z General secretion pathway protein I VC0395_A2302 ENOG4105VWV general secretion pathway protein h VC0395_A2303 ENOG4108VAU general secretion pathway protein G VC0395_A2304 ENOG4105D7Q type ii secretion system VC0395_A2305 ENOG4107QHF type ii secretion system protein e VC0395_A2307 ENOG4108XKW General secretion pathway protein C VC0395_A2308 ENOG4105VEJ Heat shock protein VC0395_A2309 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) VC0395_A2310 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase VC0395_A2312 ENOG4105SUU thioesterase domain VC0395_A2313 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) VC0395_A2315 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) VC0395_A2318 ENOG4105C5F glutamine synthetase VC0395_A2320 ENOG4105CUX Signal transduction histidine kinase VC0395_A2321 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VC0395_A2322 ENOG4105BZU Histidine kinase VC0395_A2323 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) VC0395_A2339 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) VC0395_A2341 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin VC0395_A2342 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) VC0395_A2351 ENOG4105CAF HipA N-terminal domain protein VC0395_A2362 ENOG4108C33 Resolvase VC0395_A2367 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) VC0395_A2370 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) VC0395_A2371 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VC0395_A2372 ENOG4105CRP Part of the ABC transporter FtsEX involved in VC0395_A2373 ENOG4105CAK Cell division ATP-binding protein ftsE VC0395_A2374 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) VC0395_A2375 ENOG4106H78 methyltransferase VC0395_A2381 ENOG4108RMU ferritin dps family protein VC0395_A2383 ENOG4105D58 Diguanylate phosphodiesterase VC0395_A2384 ENOG410829K Lysine exporter protein (Lyse ygga) VC0395_A2385 ENOG4108EUD Lysophospholipase VC0395_A2386 ENOG4105DQF Hydrolase VC0395_A2389 ENOG4105BZU Histidine kinase VC0395_A2390 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant VC0395_A2391 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VC0395_A2392 ENOG4105CT0 Protein of unknown function, DUF484 VC0395_A2393 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) VC0395_A2394 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) VC0395_A2396 ENOG4105XQ6 frataxin-like protein VC0395_A2397 ENOG4107T0K Adenylate cyclase VC0395_A2398 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) VC0395_A2399 ENOG41076E6 Uroporphyrinogen-III Synthase VC0395_A2400 ENOG4105ECF c-methyltransferase VC0395_A2401 ENOG410601J HemY protein VC0395_A2402 ENOG4105D4P Coproporphyrinogen iii oxidase VC0395_A2403 ENOG4105XCT Protein of unknown function (DUF2489) VC0395_A2404 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) VC0395_A2406 ENOG4106RE7 Cytochrome VC0395_A2407 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) VC0395_A2409 ENOG4105C2M dna polymerase I VC0395_A2413 ENOG4105D52 delta-aminolevulinic acid dehydratase VC0395_A2415 ENOG4105F8V Hydrolase, tatD family VC0395_A2416 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) VC0395_A2418 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A2419 ENOG4105X6C Flagellar basal body-associated protein FliL VC0395_A2420 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) VC0395_A2421 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) VC0395_A2422 ENOG4105E55 glycerol-3-phosphate acyltransferase VC0395_A2423 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) VC0395_A2425 ENOG4107R73 Mate efflux family protein VC0395_A2426 ENOG4105CA0 peroxidase VC0395_A2427 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) VC0395_A2428 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) VC0395_A2429 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VC0395_A2430 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) VC0395_A2431 ENOG4105JC1 sterol-binding domain protein VC0395_A2432 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) VC0395_A2433 ENOG4105CGY Dna recombination protein VC0395_A2434 ENOG4105CBX hi0933 family VC0395_A2436 ENOG4108V6B universal stress protein B VC0395_A2437 ENOG41090A1 ferritin VC0395_A2438 ENOG4108M6U Universal stress protein A VC0395_A2439 ENOG4105EMK carboxylate amino acid amine transporter VC0395_A2441 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) VC0395_A2442 ENOG4105BZU Histidine kinase VC0395_A2443 ENOG4108VVK transcriptional Regulator, AsnC VC0395_A2445 ENOG4105CNH Multidrug resistance protein MdtL VC0395_A2447 ENOG4105DC7 peptidase M24 VC0395_A2447 ENOG4105DC7 peptidase M24 VC0395_A2448 ENOG4105D41 biosynthesis protein thiH VC0395_A2449 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) VC0395_A2450 ENOG4105D06 uba thif-type nad fad binding protein VC0395_A2452 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) VC0395_A2453 ENOG4105WMR Protein CrcB homolog VC0395_A2463 ENOG4108Z0R Transferase VC0395_A2464 ENOG4105E2X shikimate dehydrogenase VC0395_A2465 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) VC0395_A2466 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VC0395_A2467 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) VC0395_A2468 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit VC0395_A2469 ENOG4108WI1 Dna topoisomerase VC0395_A2470 ENOG4108RPN Protein smg homolog VC0395_A2471 ENOG4105C79 DNA protecting protein DprA VC0395_A2472 ENOG4108WZM domain protein VC0395_A2473 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) VC0395_A2474 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) VC0395_A2475 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B VC0395_A2476 ENOG4105C1A potassium transporter peripheral membrane VC0395_A2477 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VC0395_A2479 ENOG4108UT2 hemolysin iii VC0395_A2480 ENOG4108N23 SpoOM-related protein VC0395_A2482 ENOG4105PC1 Conserved Protein VC0395_A2484 ENOG4105E27 serine threonine protein kinase VC0395_A2485 ENOG4108Z33 Thiol disulfide Interchange Protein VC0395_A2486 ENOG4106HNH Acyl-transferase VC0395_A2487 ENOG4105C0P Mg chelatase subunit ChlI VC0395_A2490 ENOG4105CM2 brancheD-chain amino acid aminotransferase VC0395_A2491 ENOG4105C01 Dihydroxy-acid dehydratase VC0395_A2492 ENOG4105C7B Threonine dehydratase VC0395_A2493 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family VC0395_A2495 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) VC0395_A2498 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit VC0395_A2499 ENOG4105C38 Glycyl-tRNA synthetase beta subunit VC0395_A2500 ENOG4105JKW Valine--pyruvate aminotransferase VC0395_A2501 ENOG4108ZNX Heat shock protein VC0395_A2504 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VC0395_A2505 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) VC0395_A2506 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) VC0395_A2507 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) VC0395_A2509 ENOG4105EAB amino acid AbC transporter VC0395_A2510 ENOG4105E5Q amino acid AbC transporter VC0395_A2513 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) VC0395_A2514 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins VC0395_A2515 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VC0395_A2516 ENOG4105QTB Flavodoxin VC0395_A2517 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) VC0395_A2518 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) VC0395_A2519 ENOG4107QJE Chromosome Partitioning Protein VC0395_A2520 ENOG4105FA0 parb-like partition protein VC0395_A2521 ENOG410684E atp synthase VC0395_A2522 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) VC0395_A2523 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VC0395_A2524 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VC0395_A2525 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) VC0395_A2526 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) VC0395_A2527 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) VC0395_A2528 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) VC0395_A2529 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) VC0395_A2530 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) VC0395_A2531 ENOG4105CZQ inner membrane transport protein YdhC VC0395_A2532 ENOG4105F52 Transcriptional regulator VC0395_A2533 ENOG4105CHU acetyl-coa acetyltransferase VC0395_A2534 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VC0395_A2535 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein VC0395_A2536 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VC0395_A2537 ENOG4108RR8 protoporphyrinogen oxidase VC0395_A2549 ENOG4105EMY transcriptional regulator VC0395_A2550 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase VC0395_A2551 ENOG4105W0Z cytoplasmic protein VC0395_A2552 ENOG4105BZS acriflavin resistance protein VC0395_A2553 ENOG410624X efflux transporter, rnd family, mfp subunit VC0395_A2554 ENOG4105Y7M Transcriptional regulator, TetR family VC0395_A2555 ENOG4105C4R Atp-dependent dna helicase VC0395_A2556 ENOG4105MPD Cytochrome VC0395_A2564 ENOG4105DEF Extracellular solute-binding protein, family 5 VC0395_A2565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VC0395_A2566 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VC0395_A2568 ENOG4105DC8 reductase VC0395_A2569 ENOG4105D6S protein involved in catabolism of external DNA VC0395_A2570 ENOG4105DGW oligopeptidase A VC0395_A2571 ENOG4105C4R Atp-dependent dna helicase VC0395_A2573 ENOG4108DMH HTH_ARAC VC0395_A2575 ENOG4105FR1 rard protein VC0395_A2576 ENOG4105C9U ATP-dependent DNA helicase RecQ VC0395_A2579 ENOG4105BZ1 (ABC) transporter VC0395_A2580 ENOG4105E0K tonB-dependent siderophore receptor VC0395_A2581 ENOG4105E0A ABC, transporter VC0395_A2582 ENOG4105J76 Periplasmic binding protein VC0395_A2583 ENOG4105S6R Iron-hydroxamate transporter permease subunit VC0395_A2584 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) VC0395_A2585 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate VC0395_A2586 ENOG4105C5Y PTS System VC0395_A2588 ENOG4105DSJ YicC domain protein VC0395_A2589 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) VC0395_A2590 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) VC0395_A2591 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase VC0395_A2592 ENOG4105D1S lipid A biosynthesis VC0395_A2593 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) VC0395_A2595 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase VC0395_A2596 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A2599 ENOG4105KDC 50s ribosomal protein l28 VC0395_A2600 ENOG4105W0E 50S ribosomal protein L33 VC0395_A2602 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) VC0395_A2603 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) VC0395_A2604 ENOG4105M5K heptosyltransferase VC0395_A2605 ENOG4106WTF Glycosyl transferase, family 2 VC0395_A2606 ENOG4105DKP glycosyl transferase, family 9 VC0395_A2607 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) VC0395_A2613 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase VC0395_A2614 ENOG4108ST3 glycosyltransferase VC0395_A2616 ENOG4105XA0 heptosyltransferase ii VC0395_A2619 ENOG4107T94 Endo-14-beta-xylanase VC0395_A2620 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) VC0395_A2621 ENOG4105CJT Mannose-1-phosphate guanylyltransferase VC0395_A2622 ENOG4107QKV phosphomannomutase VC0395_A2623 ENOG4105C0K Gdp-mannose 4,6-dehydratase VC0395_A2624 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VC0395_A2627 ENOG4105EY8 ABC transporter VC0395_A2629 ENOG4105CEY Amp-dependent synthetase and ligase VC0395_A2630 ENOG4108EKI Dehydrogenase VC0395_A2632 ENOG4108UT6 Transferase hexapeptide repeat containing protein VC0395_A2634 ENOG410600T transposase VC0395_A2635 ENOG410600T transposase VC0395_A2640 ENOG4105D3Q Sugar transferase VC0395_A2642 ENOG4105CY0 Metallo-Beta-Lactamase VC0395_A2643 ENOG4105CUY Mechanosensitive ion channel VC0395_A2644 ENOG4108RG0 uracil-dna glycosylase VC0395_A2645 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase VC0395_A2646 ENOG4105R2J Conserved Protein VC0395_A2647 ENOG4105EIP mannose-6-phosphate isomerase VC0395_A2648 ENOG4105DKQ ROK family VC0395_A2650 ENOG4105K70 DNA-binding protein VC0395_A2652 ENOG4105C12 Phosphoribosylglycinamide synthetase VC0395_A2653 ENOG4105DC1 bifunctional purine biosynthesis protein purh VC0395_A2655 ENOG4105W1Y Transcriptional regulator VC0395_A2656 ENOG4108M3R transcriptional activator CadC VC0395_A2657 ENOG4105D5Q Arginine ornithine antiporter VC0395_A2658 ENOG4105CXN decarboxylase VC0395_A2659 ENOG4105C8Q Methyl-accepting chemotaxis VC0395_A2662 ENOG4105E0K tonB-dependent siderophore receptor VC0395_A2663 ENOG4108UHU Aldolase VC0395_A2664 ENOG4105C6Z Gluconate VC0395_A2665 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family VC0395_A2666 ENOG4105C01 Dihydroxy-acid dehydratase VC0395_A2667 ENOG4105DIQ Transcriptional regulator VC0395_A2669 ENOG4107R3N Filamentation induced by cAMP protein fic VC0395_A2674 ENOG41060M0 Crispr-associated protein, cse4 family VC0395_A2676 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) VC0395_A2685 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) VC0395_A2686 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VC0395_A2687 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) VC0395_A2688 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VC0395_A2689 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein VC0395_A2690 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) VC0395_A2691 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VC0395_A2694 ENOG4105D8G Major Facilitator superfamily VC0395_A2695 ENOG4105BZU Histidine kinase VC0395_A2696 ENOG4105C9X ppx gppa phosphatase VC0395_A2697 ENOG4105C1J atp-dependent rna helicase VC0395_A2698 ENOG4105K63 Thioredoxin VC0395_A2699 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) VC0395_A2702 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) VC0395_A2704 ENOG4107QK7 reductase VC0395_A2714 ENOG4105JIM Phosphatidylserine synthase VC0395_A2716 ENOG4105D4A Cell wall formation (By similarity) VC0395_A2717 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase VC0395_A2718 ENOG4105CS9 pantothenic acid kinase VC0395_A2723 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VC0395_A2724 ENOG4105PM1 preprotein translocase subunit SecE VC0395_A2725 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) VC0395_A2726 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) VC0395_A2727 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) VC0395_A2728 ENOG4108VZM 50s ribosomal protein L10 VC0395_A2729 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) VC0395_A2730 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VC0395_A2731 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) VC0395_A2732 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor VC0395_A2733 ENOG4105E09 nadh pyrophosphatase VC0395_A2734 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) VC0395_A2735 ENOG41062JF Transcriptional regulator VC0395_A2736 ENOG41063SB peptidase VC0395_A2738 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) VC0395_A2740 ENOG4107QWE )-transporter VC0395_A2741 ENOG4105DJ4 phosphatidylserine decarboxylase VC0395_A2742 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) VC0395_A2743 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) VC0395_A2753 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VC0395_A2754 ENOG4105K8N protein family UPF0079, ATPase VC0395_A2755 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VC0395_A2756 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) VC0395_A2757 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) VC0395_A2758 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) VC0395_A2759 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) VC0395_A2760 ENOG4107QJR hflk protein VC0395_A2761 ENOG4105EPW hflc protein VC0395_A2763 ENOG41069P5 Protein slyX homolog VC0395_A2766 ENOG4108V1T peptidylprolyl cis-trans isomerase VC0395_A2767 ENOG4105WWK YheO domain protein VC0395_A2768 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) VC0395_A2769 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) VC0395_A2771 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) VC0395_A2772 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) VC0395_A2773 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) VC0395_A2774 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) VC0395_A2775 ENOG4105W53 bacterioferritin-associated ferredoxin VC0395_A2776 ENOG4108UQY Iron-storage protein VC0395_A2777 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) VC0395_A2778 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) VC0395_A2779 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) VC0395_A2780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) VC0395_A2782 ENOG4105CDU Replicative dna helicase VC0395_A2783 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VC0395_A2784 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme VC0395_A2785 ENOG4107QP8 phosphohexose isomerase VC0395_A2788 ENOG4105MYN Zinc uptake regulation protein VC0395_A2790 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VC0395_A2791 ENOG4105P4Z Phage shock protein G VC0395_A2795 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) VC0395_A2796 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) VC0395_A2797 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) VC0395_A2807 ENOG4105EEQ Na H antiporter VC0395_A2808 ENOG4105C3R Methionine synthase VC0395_A2809 ENOG4105CFH Aspartokinase VC0395_A2810 ENOG4105C5R Aminotransferase VC0395_A2812 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VC0395_A2813 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase VC0395_A2814 ENOG41086KC Transcriptional regulator VC0395_A2815 ENOG4108UUM single-stranded DNA-binding protein VC0395_A2816 ENOG41062P1 Diguanylate cyclase phosphodiesterase VC0395_A2820 ENOG4105E4G Type IV pilus VC0395_A2823 ENOG4107QHF type ii secretion system protein e VC0395_A2824 ENOG4105D7Q type ii secretion system VC0395_A2826 ENOG4105X0D Fimbrial protein VC0395_A2834 ENOG4105DFF Rod shape-determining protein mreb VC0395_A2835 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) VC0395_A2836 ENOG4105VQ7 Rod shape-determining protein MreD VC0395_A2837 ENOG4108Z03 MAF-like protein VC0395_A2838 ENOG4105C03 ribonuclease VC0395_A2839 ENOG4105QD6 exported protein VC0395_A2841 ENOG4105D1U peptidase U62 modulator of DNA gyrase VC0395_A2842 ENOG4105CEU Arginine dihydrolase VC0395_A2846 ENOG41081QV Universal stress protein VC0395_A2849 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) VC0395_A2850 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) VC0395_A2851 ENOG4105D5Q Arginine ornithine antiporter VC0395_A2852 ENOG4105EAH synthase VC0395_A2853 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) VC0395_A2854 ENOG4105K46 50S ribosomal protein l27 VC0395_A2855 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control VC0395_A2856 ENOG4105DWK Membrane VC0395_A2857 ENOG4107XM3 UPF0442 protein VC0395_A2859 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) VC0395_A2860 ENOG4105NWN ApaG protein VC0395_A2861 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) VC0395_A2862 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) VC0395_A2863 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) VC0395_A2864 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) VC0395_A2865 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)