locus-tag	class	description
VC395_0003	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VC395_0004	COG1404	Belongs to the peptidase S8 family
VC395_0005	COG4206	TonB-dependent receptor
VC395_0006	COG3335	DDE superfamily endonuclease
VC395_0010	COG3550	peptidyl-serine autophosphorylation
VC395_0021	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VC395_0026	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VC395_0029	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_0030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VC395_0031	COG2177	Part of the ABC transporter FtsEX involved in
VC395_0032	COG2884	Cell division ATP-binding protein ftsE
VC395_0033	COG0552	protein localization to endoplasmic reticulum
VC395_0034	COG0742	ribosomal rna small subunit methyltransferase
VC395_0041	COG0783	Belongs to the Dps family
VC395_0043	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VC395_0044	COG1280	lysine exporter protein (LysE YggA)
VC395_0045	COG2267	carboxylic ester hydrolase activity
VC395_0046	COG0561	phosphatase activity
VC395_0050	COG3287	FIST C domain
VC395_0050	COG2200	EAL domain
VC395_0050	COG2199	diguanylate cyclase activity
VC395_0051	COG1011	Hydrolase
VC395_0052	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VC395_0054	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VC395_0055	COG0019	diaminopimelate decarboxylase activity
VC395_0057	COG1965	Belongs to the frataxin family
VC395_0058	COG3072	Adenylate cyclase
VC395_0060	COG0181	hydroxymethylbilane synthase activity
VC395_0061	COG1587	Uroporphyrinogen-III synthase
VC395_0062	COG2959	enzyme of heme biosynthesis
VC395_0063	COG3071	HemY protein
VC395_0064	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VC395_0066	COG3078	GTPase activator activity
VC395_0069	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VC395_0072	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VC395_0072	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VC395_0077	COG0084	hydrolase, TatD family'
VC395_0080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VC395_0082	COG0840	transmembrane signaling receptor activity
VC395_0083	COG1580	Controls the rotational direction of flagella during chemotaxis
VC395_0085	COG3161	chorismate lyase activity
VC395_0086	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VC395_0087	COG2937	Belongs to the GPAT DAPAT family
VC395_0088	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VC395_0090	COG0534	Mate efflux family protein
VC395_0091	COG1858	cytochrome C peroxidase
VC395_0092	COG0805	protein transport
VC395_0093	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VC395_0094	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VC395_0095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VC395_0097	COG2226	methyltransferase
VC395_0098	COG1322	Protein conserved in bacteria
VC395_0100	COG2081	HI0933 family
VC395_0102	COG1528	Iron-storage protein
VC395_0104	COG0589	response to stress
VC395_0105	COG0697	spore germination
VC395_0107	COG0742	ribosomal rna small subunit methyltransferase
VC395_0108	COG5001	Diguanylate cyclase
VC395_0108	COG5002	protein histidine kinase activity
VC395_0109	COG1522	sequence-specific DNA binding
VC395_0113	COG0006	proline dipeptidase activity
VC395_0113	COG0006	proline dipeptidase activity
VC395_0114	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VC395_0115	COG2022	thiamine diphosphate biosynthetic process
VC395_0116	COG2104	thiamine diphosphate biosynthetic process
VC395_0117	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VC395_0119	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VC395_0120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VC395_0122	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VC395_0124	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VC395_0125	COG0408	coproporphyrinogen oxidase activity
VC395_0126	COG0009	L-threonylcarbamoyladenylate synthase
VC395_0128	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VC395_0129	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VC395_0130	COG0551	DNA topoisomerase type I activity
VC395_0131	COG2922	Belongs to the Smg family
VC395_0132	COG0758	DNA mediated transformation
VC395_0133	COG1652	LysM domain
VC395_0134	COG0242	peptide deformylase activity
VC395_0135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VC395_0136	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VC395_0136	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VC395_0137	COG0569	domain protein
VC395_0138	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VC395_0140	COG1272	protein, Hemolysin III
VC395_0141	COG4326	sporulation control protein
VC395_0143	COG3084	Protein conserved in bacteria
VC395_0145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VC395_0146	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VC395_0147	COG0204	Acyl-transferase
VC395_0148	COG0606	chelatase, subunit chli
VC395_0151	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VC395_0152	COG0129	dihydroxy-acid dehydratase activity
VC395_0154	COG0604	alcohol dehydrogenase
VC395_0156	COG0425	Belongs to the sulfur carrier protein TusA family
VC395_0158	COG2119	membrane
VC395_0159	COG0752	glycyl-tRNA synthetase alpha subunit
VC395_0160	COG0751	glycine-tRNA ligase activity
VC395_0161	COG3977	Valine--pyruvate aminotransferase
VC395_0162	COG0071	Belongs to the small heat shock protein (HSP20) family
VC395_0165	COG0187	DNA topoisomerase II activity
VC395_0166	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VC395_0167	COG0592	DNA-directed DNA polymerase activity
VC395_0168	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VC395_0172	COG1126	abc transporter atp-binding protein
VC395_0173	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VC395_0174	COG0594	ribonuclease P activity
VC395_0175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VC395_0176	COG0706	membrane insertase activity
VC395_0177	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VC395_0178	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VC395_0180	COG0445	tRNA wobble uridine modification
VC395_0181	COG0357	Ribosomal RNA small subunit methyltransferase G
VC395_0182	COG1192	Involved in chromosome partitioning
VC395_0183	COG1475	DNA binding
VC395_0184	COG3312	ion transport
VC395_0185	COG0356	it plays a direct role in the translocation of protons across the membrane
VC395_0187	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VC395_0188	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VC395_0189	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VC395_0190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VC395_0191	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VC395_0192	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VC395_0193	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VC395_0194	COG2814	Major facilitator Superfamily
VC395_0195	COG0583	DNA-binding transcription factor activity
VC395_0196	COG0183	Belongs to the thiolase family
VC395_0197	COG1250	3-hydroxyacyl-CoA dehydrogenase
VC395_0197	COG1024	Enoyl-CoA hydratase
VC395_0198	COG1739	Uncharacterized protein family UPF0029
VC395_0199	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VC395_0200	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VC395_0204	COG0583	DNA-binding transcription factor activity
VC395_0205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VC395_0206	COG2960	long-chain fatty acid transporting porin activity
VC395_0207	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VC395_0208	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_0209	COG1309	transcriptional regulator
VC395_0214	COG0747	negative chemotaxis
VC395_0216	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VC395_0218	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_0219	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VC395_0222	COG0210	DNA helicase
VC395_0223	COG1280	lysine exporter protein (LysE YggA)
VC395_0227	COG2962	Rard protein
VC395_0228	COG0514	ATP-dependent DNA helicase (RecQ)
VC395_0231	COG1132	(ABC) transporter
VC395_0232	COG4774	siderophore transport
VC395_0233	COG1120	ATPase activity
VC395_0238	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VC395_0239	COG1263	PTS System
VC395_0239	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_0241	COG1561	YicC-like family, N-terminal region
VC395_0242	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VC395_0243	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VC395_0244	COG1560	Kdo2-lipid A biosynthetic process
VC395_0245	COG1560	Kdo2-lipid A biosynthetic process
VC395_0246	COG1309	transcriptional regulator
VC395_0247	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VC395_0250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VC395_0251	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VC395_0253	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VC395_0254	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VC395_0255	COG0859	PFAM glycosyl transferase family 9
VC395_0256	COG0463	Glycosyl transferase, family 2
VC395_0257	COG0859	PFAM glycosyl transferase family 9
VC395_0259	COG3642	lipopolysaccharide core region biosynthetic process
VC395_0265	COG1519	Transferase
VC395_0272	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VC395_0273	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VC395_0273	COG0662	Cupin 2, conserved barrel domain protein
VC395_0274	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VC395_0275	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VC395_0281	COG0318	PFAM AMP-dependent synthetase and ligase
VC395_0282	COG1454	alcohol dehydrogenase
VC395_0282	COG1012	belongs to the aldehyde dehydrogenase family
VC395_0293	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VC395_0294	COG0668	transmembrane transport
VC395_0295	COG1573	uracil-dna glycosylase
VC395_0297	COG3068	Protein conserved in bacteria
VC395_0299	COG1940	carbohydrate kinase activity
VC395_0300	COG1253	flavin adenine dinucleotide binding
VC395_0302	COG0776	regulation of translation
VC395_0304	COG0151	Belongs to the GarS family
VC395_0305	COG0138	bifunctional purine biosynthesis protein purh
VC395_0306	COG0789	Transcriptional regulator
VC395_0307	COG3710	Transcriptional regulator
VC395_0309	COG0531	amino acid
VC395_0310	COG1982	Orn Lys Arg decarboxylase major
VC395_0311	COG0840	transmembrane signaling receptor activity
VC395_0314	COG0800	Aldolase
VC395_0316	COG3265	gluconokinase activity
VC395_0317	COG0129	dihydroxy-acid dehydratase activity
VC395_0318	COG1609	Transcriptional regulator
VC395_0325	COG1857	crispr-associated protein
VC395_0327	COG1518	maintenance of DNA repeat elements
VC395_0334	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VC395_0335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VC395_0337	COG2264	protein methyltransferase activity
VC395_0339	COG0439	Biotin carboxylase
VC395_0340	COG0511	ligase activity, forming carbon-carbon bonds
VC395_0341	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VC395_0342	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VC395_0346	COG2814	Major facilitator Superfamily
VC395_0347	COG2205	protein histidine kinase activity
VC395_0347	COG0784	Response regulator, receiver
VC395_0348	COG0248	Ppx GppA phosphatase
VC395_0349	COG0513	Belongs to the DEAD box helicase family
VC395_0350	COG3118	belongs to the thioredoxin family
VC395_0351	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VC395_0353	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VC395_0358	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VC395_0361	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VC395_0363	COG1072	(Pantothenic acid kinase))
VC395_0364	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VC395_0365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VC395_0366	COG0250	Participates in transcription elongation, termination and antitermination
VC395_0367	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VC395_0368	COG0081	regulation of translation
VC395_0369	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VC395_0370	COG0222	ribosome binding
VC395_0371	COG0085	RNA polymerase activity
VC395_0372	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VC395_0373	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VC395_0374	COG2816	NAD+ diphosphatase activity
VC395_0375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VC395_0378	COG4942	peptidase
VC395_0379	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VC395_0381	COG0471	metal ion transport
VC395_0381	COG0490	domain, Protein
VC395_0382	COG0688	phosphatidylethanolamine metabolic process
VC395_0383	COG1162	GTPase activity
VC395_0384	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VC395_0385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VC395_0386	COG0802	atpase or kinase
VC395_0388	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VC395_0389	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VC395_0390	COG1923	regulation of RNA biosynthetic process
VC395_0391	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VC395_0392	COG0330	HflC and HflK could
VC395_0393	COG0330	HflC and HflK could
VC395_0394	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VC395_0395	COG2900	Belongs to the SlyX family
VC395_0397	COG0545	Peptidyl-prolyl cis-trans isomerase
VC395_0398	COG2964	Protein conserved in bacteria
VC395_0399	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VC395_0400	COG2923	Belongs to the DsrF TusC family
VC395_0402	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VC395_0403	COG0049	tRNA binding
VC395_0404	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VC395_0405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VC395_0407	COG2906	2 iron, 2 sulfur cluster binding
VC395_0409	COG0360	Binds together with S18 to 16S ribosomal RNA
VC395_0410	COG2965	DNA replication, synthesis of RNA primer
VC395_0411	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VC395_0412	COG0359	binds to the 23S rRNA
VC395_0414	COG0305	Participates in initiation and elongation during chromosome replication
VC395_0415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VC395_0416	COG0432	Pfam Uncharacterised protein family UPF0047
VC395_0417	COG0166	Belongs to the GPI family
VC395_0421	COG0735	belongs to the Fur family
VC395_0422	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VC395_0428	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VC395_0429	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VC395_0430	COG0175	sulfate reduction
VC395_0434	COG1410	methionine synthase
VC395_0434	COG0646	methionine synthase
VC395_0435	COG0527	aspartate kinase activity
VC395_0436	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VC395_0438	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VC395_0441	COG0629	single-stranded DNA binding
VC395_0442	COG2199	diguanylate cyclase activity
VC395_0442	COG2200	EAL domain
VC395_0447	COG3267	Type II secretory pathway component ExeA
VC395_0447	COG3409	Peptidoglycan-binding domain 1 protein
VC395_0449	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_0450	COG1459	type II secretion system
VC395_0459	COG1077	Cell shape determining protein MreB Mrl
VC395_0460	COG1792	Involved in formation and maintenance of cell shape
VC395_0461	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VC395_0462	COG0424	maF-like protein
VC395_0463	COG1530	ribonuclease E activity
VC395_0464	COG3164	Protein of unknown function
VC395_0465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VC395_0466	COG0312	modulator of DNA gyrase
VC395_0467	COG2235	arginine
VC395_0472	COG0589	response to stress
VC395_0475	COG1438	arginine binding
VC395_0476	COG0039	L-malate dehydrogenase activity
VC395_0477	COG0531	amino acid
VC395_0478	COG0142	geranyltranstransferase activity
VC395_0479	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VC395_0480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VC395_0481	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VC395_0482	COG2966	Psort location CytoplasmicMembrane, score
VC395_0483	COG3610	response to peptide
VC395_0485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VC395_0486	COG2967	ApaG domain
VC395_0487	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VC395_0488	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VC395_0489	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VC395_0490	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VC395_0491	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VC395_0494	COG0741	lytic transglycosylase activity
VC395_0495	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VC395_0496	COG1194	a g-specific adenine glycosylase
VC395_0497	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VC395_0498	COG2066	Belongs to the glutaminase family
VC395_0499	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VC395_0500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VC395_0502	COG1872	DUF167
VC395_0503	COG0762	integral membrane protein
VC395_0504	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VC395_0505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VC395_0509	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VC395_0510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VC395_0511	COG1678	Uncharacterized ACR, COG1678
VC395_0512	COG0189	ligase activity
VC395_0513	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VC395_0514	COG2356	endonuclease I
VC395_0515	COG3091	SprT-like family
VC395_0516	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VC395_0517	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VC395_0518	COG0583	DNA-binding transcription factor activity
VC395_0519	COG4771	TonB-dependent receptor
VC395_0520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VC395_0521	COG0126	phosphoglycerate kinase activity
VC395_0522	COG0191	fructose-bisphosphate aldolase activity
VC395_0524	COG0668	transmembrane transport
VC395_0525	COG1279	arginine transmembrane transporter activity
VC395_0526	COG0583	DNA-binding transcription factor activity
VC395_0529	COG0469	pyruvate kinase activity
VC395_0530	COG1349	DNA-binding transcription factor activity
VC395_0531	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VC395_0532	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VC395_0534	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VC395_0535	COG0358	DNA primase activity
VC395_0536	COG1610	YqeY-like protein
VC395_0537	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VC395_0538	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VC395_0540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VC395_0541	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VC395_0542	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VC395_0543	COG1968	undecaprenyl-diphosphatase activity
VC395_0544	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VC395_0545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VC395_0546	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VC395_0547	COG0585	pseudouridine synthase activity
VC395_0548	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VC395_0549	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VC395_0550	COG4942	peptidase
VC395_0550	COG1388	LysM domain
VC395_0551	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VC395_0552	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VC395_0557	COG4208	sulfate ABC transporter
VC395_0558	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VC395_0560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VC395_0561	COG2137	regulation of response to DNA damage stimulus
VC395_0562	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VC395_0564	COG0527	aspartate kinase activity
VC395_0565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VC395_0566	COG3630	sodium ion export across plasma membrane
VC395_0567	COG5016	pyruvate
VC395_0567	COG0511	ligase activity, forming carbon-carbon bonds
VC395_0568	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VC395_0570	COG1238	metal cluster binding
VC395_0571	COG0612	Peptidase, M16
VC395_0573	COG2918	glutathione biosynthetic process
VC395_0574	COG1854	S-ribosylhomocysteine lyase activity
VC395_0575	COG4536	flavin adenine dinucleotide binding
VC395_0576	COG4137	Cytochrome C assembly protein
VC395_0577	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VC395_0578	COG0228	four-way junction DNA binding
VC395_0579	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VC395_0580	COG0336	Belongs to the RNA methyltransferase TrmD family
VC395_0581	COG0335	large ribosomal subunit rRNA binding
VC395_0582	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VC395_0583	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VC395_0585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VC395_0587	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VC395_0588	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VC395_0590	COG0723	plastoquinol--plastocyanin reductase activity
VC395_0591	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VC395_0592	COG2857	Cytochrome c1
VC395_0593	COG0625	glutathione transferase activity
VC395_0594	COG2969	positive regulation of protein catabolic process
VC395_0595	COG2823	Periplasmic or secreted lipoprotein
VC395_0596	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VC395_0597	COG0792	nuclease activity
VC395_0598	COG3107	peptidoglycan biosynthetic process
VC395_0599	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VC395_0603	COG0288	reversible hydration of carbon dioxide
VC395_0604	COG0659	secondary active sulfate transmembrane transporter activity
VC395_0606	COG1131	(ABC) transporter
VC395_0607	COG0842	Transport permease protein
VC395_0608	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VC395_0609	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VC395_0610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VC395_0612	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VC395_0613	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VC395_0614	COG1489	DNA binding
VC395_0618	COG1643	Atp-dependent helicase
VC395_0619	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VC395_0620	COG1752	Esterase of the alpha-beta hydrolase superfamily
VC395_0621	COG1049	propionate catabolic process, 2-methylcitrate cycle
VC395_0622	COG3112	Uncharacterised protein family (UPF0231)
VC395_0623	COG0347	Belongs to the P(II) protein family
VC395_0624	COG0004	ammonium transporteR
VC395_0625	COG1840	ABC-type Fe3 transport system, periplasmic component
VC395_0627	COG3842	ATPase activity
VC395_0628	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VC395_0631	COG2971	BadF BadG BcrA BcrD
VC395_0633	COG4608	Belongs to the ABC transporter superfamily
VC395_0634	COG0444	Belongs to the ABC transporter superfamily
VC395_0635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VC395_0636	COG0601	transmembrane transport
VC395_0637	COG0747	negative chemotaxis
VC395_0640	COG2813	Specifically methylates the guanine in position
VC395_0641	COG0628	permease
VC395_0643	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VC395_0644	COG0316	Belongs to the HesB IscA family
VC395_0647	COG0739	heme binding
VC395_0648	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VC395_0649	COG2027	D-alanyl-D-alanine carboxypeptidase
VC395_0650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VC395_0651	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VC395_0652	COG1534	Rna-binding protein
VC395_0653	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VC395_0654	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VC395_0655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VC395_0656	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VC395_0657	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VC395_0658	COG0779	Required for maturation of 30S ribosomal subunits
VC395_0659	COG0195	Participates in both transcription termination and antitermination
VC395_0660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VC395_0661	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VC395_0662	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VC395_0663	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VC395_0664	COG1185	polyribonucleotide nucleotidyltransferase activity
VC395_0665	COG4785	May be involved in cell division
VC395_0672	COG3153	acetyltransferase
VC395_0676	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VC395_0677	COG0513	Belongs to the DEAD box helicase family
VC395_0678	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VC395_0680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VC395_0681	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VC395_0682	COG2204	response regulator
VC395_0684	COG0667	Aldo Keto reductase
VC395_0685	COG3066	DNA modification
VC395_0688	COG0494	nUDIX hydrolase
VC395_0689	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VC395_0690	COG0730	response to heat
VC395_0691	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VC395_0692	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VC395_0693	COG1283	sodium-dependent phosphate transmembrane transporter activity
VC395_0694	COG0583	DNA-binding transcription factor activity
VC395_0695	COG0640	Transcriptional regulator
VC395_0696	COG0268	Binds directly to 16S ribosomal RNA
VC395_0697	COG0728	peptidoglycan biosynthetic process
VC395_0698	COG0196	riboflavin kinase activity
VC395_0699	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VC395_0700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VC395_0701	COG1047	Peptidyl-prolyl cis-trans
VC395_0702	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VC395_0704	COG1966	Carbon starvation protein
VC395_0707	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VC395_0708	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VC395_0709	COG1472	Belongs to the glycosyl hydrolase 3 family
VC395_0710	COG3279	Response regulator of the LytR AlgR family
VC395_0711	COG3275	phosphorelay sensor kinase activity
VC395_0712	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VC395_0713	COG0287	Prephenate dehydrogenase
VC395_0713	COG1605	Chorismate mutase
VC395_0715	COG0488	(ABC) transporter
VC395_0718	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VC395_0719	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VC395_0720	COG5001	Diguanylate cyclase
VC395_0721	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VC395_0722	COG0077	Prephenate dehydratase
VC395_0722	COG1605	Chorismate mutase
VC395_0723	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VC395_0725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VC395_0726	COG0564	pseudouridine synthase activity
VC395_0728	COG0542	response to heat
VC395_0733	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VC395_0735	COG2974	May be involved in recombination
VC395_0736	COG0745	RESPONSE REGULATOR receiver
VC395_0737	COG5002	protein histidine kinase activity
VC395_0739	COG0248	Ppx GppA phosphatase
VC395_0740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VC395_0742	COG0581	inorganic phosphate transmembrane transporter activity
VC395_0743	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VC395_0747	COG3142	Participates in the control of copper homeostasis
VC395_0748	COG0450	alkyl hydroperoxide reductase
VC395_0749	COG0583	DNA-binding transcription factor activity
VC395_0751	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VC395_0754	COG0517	IMP dehydrogenase activity
VC395_0756	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VC395_0758	COG0343	queuine tRNA-ribosyltransferase activity
VC395_0759	COG1862	Preprotein translocase
VC395_0760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VC395_0761	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VC395_0762	COG0483	inositol monophosphate 1-phosphatase activity
VC395_0764	COG1959	2 iron, 2 sulfur cluster binding
VC395_0765	COG1104	cysteine desulfurase activity
VC395_0766	COG0822	iron-sulfur transferase activity
VC395_0768	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VC395_0769	COG0443	Heat shock 70 kDa protein
VC395_0770	COG0633	Ferredoxin
VC395_0771	COG2975	iron-sulfur cluster assembly
VC395_0772	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VC395_0773	COG0105	UTP biosynthetic process
VC395_0774	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VC395_0776	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VC395_0777	COG0124	histidyl-tRNA synthetase
VC395_0778	COG2976	Protein conserved in bacteria
VC395_0779	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VC395_0780	COG1160	GTP binding
VC395_0783	COG1570	exodeoxyribonuclease VII activity
VC395_0784	COG0516	GMP reductase activity
VC395_0784	COG0517	IMP dehydrogenase activity
VC395_0785	COG0519	Catalyzes the synthesis of GMP from XMP
VC395_0785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VC395_0787	COG1584	GPR1 FUN34 yaaH family protein
VC395_0788	COG3433	isochorismatase activity
VC395_0788	COG1535	isochorismatase
VC395_0789	COG1021	2,3-dihydroxybenzoate-AMP ligase
VC395_0790	COG1169	isochorismate synthase
VC395_0791	COG1028	Short-chain dehydrogenase reductase Sdr
VC395_0793	COG4592	Periplasmic binding protein
VC395_0794	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VC395_0795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VC395_0796	COG1120	ATPase activity
VC395_0798	COG0583	DNA-binding transcription factor activity
VC395_0800	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VC395_0801	COG1115	amino acid carrier protein
VC395_0803	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VC395_0804	COG0583	DNA-binding transcription factor activity
VC395_0807	COG4565	transcriptional regulatory protein
VC395_0809	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VC395_0810	COG5016	pyruvate
VC395_0810	COG0511	ligase activity, forming carbon-carbon bonds
VC395_0811	COG3630	sodium ion export across plasma membrane
VC395_0813	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VC395_0814	COG3052	prosthetic group binding
VC395_0815	COG2301	Belongs to the HpcH HpaI aldolase family
VC395_0816	COG3051	citrate lyase alpha subunit
VC395_0817	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VC395_0818	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VC395_0820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VC395_0821	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VC395_0823	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VC395_0836	COG1012	belongs to the aldehyde dehydrogenase family
VC395_0840	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VC395_0841	COG0840	transmembrane signaling receptor activity
VC395_0842	COG3710	Transcriptional regulator
VC395_0847	COG4796	Type ii and iii secretion system protein
VC395_0851	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_0852	COG1459	type II secretion system
VC395_0854	COG2207	Transcriptional regulator
VC395_0855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VC395_0859	COG0739	heme binding
VC395_0861	COG3064	Membrane
VC395_0863	COG0582	viral genome integration into host DNA
VC395_0864	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VC395_0865	COG2867	negative regulation of translational initiation
VC395_0866	COG2914	Belongs to the UPF0125 (RnfH) family
VC395_0867	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VC395_0868	COG0497	DNA recombination
VC395_0869	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VC395_0870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VC395_0871	COG0443	Heat shock 70 kDa protein
VC395_0872	COG0484	heat shock protein binding
VC395_0874	COG4968	Prepilin-type N-terminal cleavage methylation domain
VC395_0879	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VC395_0880	COG0590	tRNA wobble adenosine to inosine editing
VC395_0882	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VC395_0885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VC395_0885	COG0047	phosphoribosylformylglycinamidine synthase activity
VC395_0886	COG1943	Transposase
VC395_0891	COG0442	prolyl-tRNA aminoacylation
VC395_0892	COG1720	tRNA m6t6A37 methyltransferase activity
VC395_0894	COG0254	rRNA binding
VC395_0895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VC395_0896	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VC395_0897	COG1671	Belongs to the UPF0178 family
VC395_0900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VC395_0903	COG3098	single-species biofilm formation
VC395_0904	COG0564	pseudouridine synthase activity
VC395_0905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VC395_0906	COG0142	geranyltranstransferase activity
VC395_0907	COG1722	exodeoxyribonuclease VII activity
VC395_0908	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VC395_0910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VC395_0910	COG0301	tRNA thio-modification
VC395_0912	COG0583	DNA-binding transcription factor activity
VC395_0913	COG2363	Small membrane protein
VC395_0914	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VC395_0915	COG1611	Belongs to the LOG family
VC395_0916	COG3706	GGDEF domain
VC395_0918	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VC395_0918	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VC395_0920	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VC395_0921	COG1464	Belongs to the NlpA lipoprotein family
VC395_0922	COG2011	ABC-type metal ion transport system permease component
VC395_0923	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VC395_0924	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VC395_0925	COG1609	Transcriptional regulator
VC395_0926	COG1263	PTS System
VC395_0926	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_0927	COG0366	Alpha amylase catalytic
VC395_0930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VC395_0932	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VC395_0933	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VC395_0934	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VC395_0935	COG0110	maltose O-acetyltransferase activity
VC395_0939	COG1045	serine acetyltransferase
VC395_0941	COG0438	transferase activity, transferring glycosyl groups
VC395_0943	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VC395_0949	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VC395_0951	COG1596	polysaccharide export
VC395_0956	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VC395_0958	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VC395_0959	COG0321	lipoyl(octanoyl) transferase activity
VC395_0960	COG2921	Belongs to the UPF0250 family
VC395_0962	COG1686	Belongs to the peptidase S11 family
VC395_0963	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VC395_0964	COG0772	Belongs to the SEDS family
VC395_0965	COG0768	penicillin binding
VC395_0966	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VC395_0967	COG0799	negative regulation of ribosome biogenesis
VC395_0968	COG1466	dna polymerase III delta subunit
VC395_0969	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VC395_0971	COG0495	leucyl-tRNA aminoacylation
VC395_0972	COG2888	peptidyl-tyrosine sulfation
VC395_0973	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VC395_0974	COG4535	Mg2 and Co2 transporter CorC
VC395_0975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VC395_0976	COG1702	phosphate starvation-inducible protein PhoH
VC395_0977	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VC395_0978	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_0979	COG2190	(PTS) system
VC395_0981	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_0983	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VC395_0984	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VC395_0985	COG3115	cell septum assembly
VC395_0986	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VC395_0989	COG0789	Transcriptional regulator
VC395_0990	COG1585	Membrane protein implicated in regulation of membrane protease activity
VC395_0991	COG0330	HflC and HflK could
VC395_0992	COG3118	belongs to the thioredoxin family
VC395_0994	COG0300	oxidoreductase activity
VC395_0995	COG1090	epimerase
VC395_0996	COG0622	Phosphoesterase
VC395_0999	COG3710	Transcriptional regulator
VC395_1000	COG0326	Molecular chaperone. Has ATPase activity
VC395_1001	COG0563	adenylate kinase activity
VC395_1002	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VC395_1006	COG0367	asparagine synthase
VC395_1007	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VC395_1007	COG4651	solute:proton antiporter activity
VC395_1008	COG1846	Transcriptional regulator
VC395_1008	COG1940	carbohydrate kinase activity
VC395_1009	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VC395_1010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_1010	COG1263	PTS System
VC395_1010	COG2190	(PTS) system
VC395_1012	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VC395_1014	COG0101	tRNA pseudouridine synthase activity
VC395_1015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VC395_1016	COG0285	dihydrofolate synthase activity
VC395_1017	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VC395_1018	COG1286	toxin biosynthetic process
VC395_1019	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VC395_1020	COG2056	Na+-H+ antiporter family
VC395_1021	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VC395_1025	COG0346	lactoylglutathione lyase activity
VC395_1026	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VC395_1027	COG4660	Part of a membrane complex involved in electron transport
VC395_1028	COG4659	FMN binding
VC395_1029	COG4658	electron transport chain
VC395_1030	COG4656	Part of a membrane complex involved in electron transport
VC395_1031	COG2878	Part of a membrane complex involved in electron transport
VC395_1032	COG4657	Part of a membrane complex involved in electron transport
VC395_1033	COG0556	nucleotide-excision repair
VC395_1035	COG2204	response regulator
VC395_1036	COG2198	Histidine kinase
VC395_1037	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VC395_1038	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VC395_1039	COG0521	Mo-molybdopterin cofactor biosynthetic process
VC395_1040	COG0315	cyclic pyranopterin monophosphate synthase activity
VC395_1041	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VC395_1042	COG0314	molybdopterin synthase activity
VC395_1043	COG2199	diguanylate cyclase activity
VC395_1045	COG4109	DRTGG domain
VC395_1048	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VC395_1050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_1050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_1051	COG0489	protein tyrosine kinase activity
VC395_1052	COG0572	uridine kinase
VC395_1053	COG2982	Protein involved in outer membrane biogenesis
VC395_1054	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VC395_1055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VC395_1057	COG2067	long-chain fatty acid transport protein
VC395_1060	COG0183	Belongs to the thiolase family
VC395_1061	COG1250	3-hydroxyacyl-CoA dehydrogenase
VC395_1061	COG1024	Enoyl-CoA hydratase
VC395_1062	COG0778	Nitroreductase
VC395_1063	COG0583	DNA-binding transcription factor activity
VC395_1064	COG0745	RESPONSE REGULATOR receiver
VC395_1066	COG2832	Protein of unknown function (DUF454)
VC395_1067	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VC395_1068	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VC395_1069	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VC395_1070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VC395_1073	COG1028	Short-chain dehydrogenase reductase Sdr
VC395_1074	COG0616	signal peptide processing
VC395_1076	COG1522	sequence-specific DNA binding
VC395_1077	COG1946	Acyl-CoA thioesterase
VC395_1081	COG3706	GGDEF domain
VC395_1083	COG0640	Transcriptional regulator
VC395_1084	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VC395_1090	COG1881	PFAM PEBP family protein
VC395_1094	COG0009	L-threonylcarbamoyladenylate synthase
VC395_1097	COG2201	protein-glutamate methylesterase activity
VC395_1099	COG5002	protein histidine kinase activity
VC395_1100	COG4191	Histidine kinase
VC395_1101	COG3300	MHYT domain
VC395_1101	COG5001	Diguanylate cyclase
VC395_1102	COG2204	response regulator
VC395_1107	COG0601	transmembrane transport
VC395_1108	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VC395_1109	COG0444	Belongs to the ABC transporter superfamily
VC395_1110	COG4608	Belongs to the ABC transporter superfamily
VC395_1111	COG0435	Glutathione S-transferase
VC395_1112	COG0857	belongs to the CobB CobQ family
VC395_1112	COG0280	phosphate acetyltransferase
VC395_1113	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VC395_1114	COG3092	negative regulation of chromosome organization
VC395_1115	COG4628	conserved protein (DUF2132)
VC395_1117	COG4120	Belongs to the binding-protein-dependent transport system permease family
VC395_1119	COG2199	diguanylate cyclase activity
VC395_1119	COG2203	Gaf domain
VC395_1121	COG0653	protein targeting
VC395_1122	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VC395_1123	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VC395_1125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VC395_1126	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VC395_1127	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VC395_1128	COG0156	8-amino-7-oxononanoate synthase activity
VC395_1129	COG2226	methyltransferase
VC395_1130	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VC395_1132	COG0501	Belongs to the peptidase M48B family
VC395_1134	COG0300	oxidoreductase activity
VC395_1137	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VC395_1139	COG2268	Band 7 protein
VC395_1141	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VC395_1142	COG2915	High frequency lysogenization protein hflD homolog
VC395_1143	COG0482	sulfurtransferase activity
VC395_1144	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VC395_1146	COG3423	Transcriptional regulator
VC395_1147	COG2801	Transposase and inactivated derivatives
VC395_1148	COG2842	Transposition protein
VC395_1168	COG0640	Transcriptional regulator
VC395_1170	COG4373	Mu-like prophage FluMu protein gp28
VC395_1171	COG4383	Mu-like prophage protein gp29
VC395_1179	COG4397	Mu-like prophage major head subunit gpT
VC395_1181	COG4387	Mu-like prophage protein GP36
VC395_1185	COG4386	tail sheath protein
VC395_1187	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
VC395_1191	COG4384	Bacteriophage Mu Gp45 protein
VC395_1193	COG3299	homolog of phage Mu protein gp47
VC395_1194	COG3778	Protein conserved in bacteria
VC395_1197	COG2916	Histone family protein nucleoid-structuring protein H-NS
VC395_1198	COG1757	Na H antiporter
VC395_1199	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VC395_1200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VC395_1201	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VC395_1202	COG0131	Imidazoleglycerol-phosphate dehydratase
VC395_1202	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VC395_1203	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VC395_1204	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VC395_1205	COG0107	imidazoleglycerol-phosphate synthase activity
VC395_1206	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VC395_1206	COG0140	phosphoribosyl-ATP diphosphatase activity
VC395_1207	COG1187	pseudouridine synthase activity
VC395_1209	COG1278	Cold shock
VC395_1210	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VC395_1211	COG0542	response to heat
VC395_1213	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VC395_1214	COG1454	alcohol dehydrogenase
VC395_1214	COG1012	belongs to the aldehyde dehydrogenase family
VC395_1215	COG1737	Transcriptional regulator
VC395_1216	COG0076	glutamate decarboxylase activity
VC395_1218	COG2431	L-lysine efflux transmembrane transporter activity
VC395_1220	COG3070	regulator of competence-specific genes
VC395_1223	COG3852	Histidine kinase
VC395_1225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VC395_1228	COG4067	protein conserved in archaea
VC395_1228	COG0189	ligase activity
VC395_1229	COG0500	methyltransferase
VC395_1230	COG4106	trans-aconitate 2-methyltransferase activity
VC395_1231	COG1801	Protein of unknown function DUF72
VC395_1232	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VC395_1233	COG1435	thymidine kinase activity
VC395_1237	COG3778	Protein conserved in bacteria
VC395_1238	COG3299	homolog of phage Mu protein gp47
VC395_1240	COG4384	Bacteriophage Mu Gp45 protein
VC395_1244	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
VC395_1246	COG4386	tail sheath protein
VC395_1250	COG4387	Mu-like prophage protein GP36
VC395_1252	COG4397	Mu-like prophage major head subunit gpT
VC395_1260	COG4383	Mu-like prophage protein gp29
VC395_1261	COG4373	Mu-like prophage FluMu protein gp28
VC395_1263	COG0640	Transcriptional regulator
VC395_1283	COG2842	Transposition protein
VC395_1284	COG2801	Transposase and inactivated derivatives
VC395_1285	COG3423	Transcriptional regulator
VC395_1288	COG0159	tryptophan synthase activity
VC395_1289	COG0133	tryptophan synthase activity
VC395_1290	COG0134	indole-3-glycerol-phosphate synthase activity
VC395_1290	COG0135	phosphoribosylanthranilate isomerase activity
VC395_1291	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VC395_1292	COG0512	Glutamine amidotransferase of anthranilate synthase
VC395_1293	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VC395_1296	COG0613	PHP domain protein
VC395_1297	COG0009	L-threonylcarbamoyladenylate synthase
VC395_1298	COG1187	pseudouridine synthase activity
VC395_1299	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VC395_1300	COG4988	ABC transporter
VC395_1301	COG0492	ferredoxin-NADP+ reductase activity
VC395_1304	COG3706	GGDEF domain
VC395_1305	COG2949	membrane
VC395_1307	COG0281	malic enzyme
VC395_1309	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VC395_1314	COG2885	chlorophyll binding
VC395_1317	COG0247	lactate metabolic process
VC395_1317	COG0277	FAD linked oxidase domain protein
VC395_1321	COG2986	histidine ammonia-lyase
VC395_1322	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VC395_1323	COG0010	Belongs to the arginase family
VC395_1324	COG1228	amidohydrolase
VC395_1328	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VC395_1330	COG5001	Diguanylate cyclase
VC395_1331	COG0417	DNA replication proofreading
VC395_1332	COG2197	response regulator
VC395_1333	COG0322	excinuclease ABC activity
VC395_1335	COG3706	GGDEF domain
VC395_1335	COG0745	RESPONSE REGULATOR receiver
VC395_1338	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VC395_1339	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_1339	COG0072	phenylalanine-tRNA ligase activity
VC395_1341	COG0776	regulation of translation
VC395_1345	COG0500	methyltransferase
VC395_1350	COG0295	cytidine deaminase activity
VC395_1351	COG1346	cytolysis
VC395_1353	COG2925	Exonuclease
VC395_1355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_1356	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VC395_1357	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VC395_1361	COG2988	succinylglutamate desuccinylase activity
VC395_1363	COG4139	cobalamin transport
VC395_1364	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VC395_1374	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VC395_1375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VC395_1376	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VC395_1380	COG2814	Major facilitator Superfamily
VC395_1382	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VC395_1388	COG3108	Peptidase M15
VC395_1389	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VC395_1392	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VC395_1397	COG1846	Transcriptional regulator
VC395_1398	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VC395_1399	COG0726	polysaccharide deacetylase
VC395_1400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VC395_1402	COG1447	Phosphotransferase system cellobiose-specific component IIA
VC395_1403	COG1486	melibiose metabolic process
VC395_1404	COG3394	polysaccharide catabolic process
VC395_1405	COG1609	Transcriptional regulator
VC395_1406	COG2943	transferase activity, transferring hexosyl groups
VC395_1407	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VC395_1408	COG0840	transmembrane signaling receptor activity
VC395_1412	COG1448	Aminotransferase
VC395_1414	COG3437	response regulator, receiver
VC395_1414	COG2770	Histidine kinase
VC395_1415	COG0352	thiamine-phosphate diphosphorylase activity
VC395_1415	COG0351	phosphomethylpyrimidine kinase
VC395_1416	COG0017	Asparaginyl-tRNA synthetase
VC395_1418	COG0720	synthase
VC395_1419	COG1760	l-serine dehydratase
VC395_1420	COG0814	amino acid
VC395_1421	COG0494	nUDIX hydrolase
VC395_1422	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VC395_1425	COG3106	COG3106 Predicted ATPase
VC395_1426	COG3768	UPF0283 membrane protein
VC395_1427	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VC395_1428	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VC395_1431	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VC395_1433	COG0471	metal ion transport
VC395_1434	COG4191	Histidine kinase
VC395_1434	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VC395_1436	COG2990	Protein conserved in bacteria
VC395_1437	COG3713	MltA-interacting MipA family protein
VC395_1438	COG2205	protein histidine kinase activity
VC395_1439	COG0745	RESPONSE REGULATOR receiver
VC395_1446	COG1129	ABC transporter
VC395_1454	COG2186	Transcriptional regulator
VC395_1455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VC395_1456	COG0372	Belongs to the citrate synthase family
VC395_1462	COG2195	Cleaves the N-terminal amino acid of tripeptides
VC395_1464	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VC395_1466	COG0625	glutathione transferase activity
VC395_1467	COG3437	response regulator, receiver
VC395_1468	COG3437	response regulator, receiver
VC395_1468	COG3850	Histidine kinase
VC395_1468	COG4999	Histidine kinase
VC395_1468	COG2205	protein histidine kinase activity
VC395_1472	COG3706	GGDEF domain
VC395_1473	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VC395_1474	COG1254	Belongs to the acylphosphatase family
VC395_1475	COG2920	part of a sulfur-relay system
VC395_1477	COG0670	Belongs to the BI1 family
VC395_1478	COG1126	abc transporter atp-binding protein
VC395_1479	COG0765	amino acid transport
VC395_1480	COG4597	amino acid ABC transporter
VC395_1481	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VC395_1483	COG0561	phosphatase activity
VC395_1484	COG0602	queuosine metabolic process
VC395_1485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VC395_1491	COG3706	GGDEF domain
VC395_1492	COG0443	Heat shock 70 kDa protein
VC395_1501	COG1643	Atp-dependent helicase
VC395_1505	COG0443	Heat shock 70 kDa protein
VC395_1507	COG0095	Lipoate-protein ligase
VC395_1509	COG0583	DNA-binding transcription factor activity
VC395_1510	COG0477	Major facilitator Superfamily
VC395_1511	COG0415	Belongs to the DNA photolyase family
VC395_1512	COG2076	Multidrug Resistance protein
VC395_1516	COG2198	Histidine kinase
VC395_1516	COG0643	Histidine kinase
VC395_1518	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VC395_1520	COG2201	protein-glutamate methylesterase activity
VC395_1521	COG0835	chemotaxis
VC395_1522	COG0840	transmembrane signaling receptor activity
VC395_1522	COG3290	protein histidine kinase activity
VC395_1524	COG0840	transmembrane signaling receptor activity
VC395_1526	COG0513	Belongs to the DEAD box helicase family
VC395_1528	COG1538	Outer membrane efflux protein
VC395_1529	COG1566	PFAM secretion protein HlyD family protein
VC395_1530	COG2814	Major facilitator Superfamily
VC395_1532	COG0840	transmembrane signaling receptor activity
VC395_1533	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VC395_1535	COG3501	Rhs element vgr protein
VC395_1540	COG1280	lysine exporter protein (LysE YggA)
VC395_1541	COG1115	amino acid carrier protein
VC395_1544	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VC395_1545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VC395_1546	COG1177	transmembrane transport
VC395_1547	COG1176	ABC-type spermidine putrescine transport system, permease component I
VC395_1548	COG3842	ATPase activity
VC395_1552	COG0037	tRNA processing
VC395_1553	COG0589	response to stress
VC395_1554	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VC395_1557	COG2217	Heavy metal translocating P-type atpase
VC395_1559	COG2010	Cytochrome c
VC395_1562	COG3278	Belongs to the heme-copper respiratory oxidase family
VC395_1565	COG0784	Response regulator, receiver
VC395_1565	COG2205	protein histidine kinase activity
VC395_1572	COG4128	Pfam Zonular occludens toxin
VC395_1601	COG3120	sequence-specific DNA binding
VC395_1602	COG1067	ATP-dependent peptidase activity
VC395_1603	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VC395_1608	COG0116	Belongs to the methyltransferase superfamily
VC395_1608	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VC395_1611	COG0167	dihydroorotate dehydrogenase activity
VC395_1614	COG0308	aminopeptidase N
VC395_1617	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VC395_1618	COG1956	GAF domain-containing protein
VC395_1619	COG1132	(ABC) transporter
VC395_1620	COG2995	paraquat-inducible protein a
VC395_1621	COG3008	intermembrane lipid transfer
VC395_1622	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VC395_1622	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VC395_1623	COG2996	Protein conserved in bacteria
VC395_1626	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VC395_1628	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VC395_1631	COG0437	4 iron, 4 sulfur cluster binding
VC395_1632	COG0243	molybdopterin cofactor binding
VC395_1632	COG3383	formate dehydrogenase (NAD+) activity
VC395_1638	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VC395_1639	COG0488	(ABC) transporter
VC395_1640	COG3852	Histidine kinase
VC395_1641	COG2204	response regulator
VC395_1643	COG4662	Binding-protein-dependent transport system inner membrane component
VC395_1644	COG3842	ATPase activity
VC395_1645	COG0746	molybdenum cofactor guanylyltransferase activity
VC395_1650	COG1940	carbohydrate kinase activity
VC395_1653	COG0840	transmembrane signaling receptor activity
VC395_1654	COG0791	NLP P60 protein
VC395_1657	COG0534	Mate efflux family protein
VC395_1659	COG1793	dna ligase
VC395_1661	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VC395_1662	COG0848	biopolymer transport protein
VC395_1663	COG0811	peptide transport
VC395_1664	COG0811	peptide transport
VC395_1667	COG1175	transmembrane transport
VC395_1668	COG0395	ABC-type sugar transport system, permease component
VC395_1669	COG3842	ATPase activity
VC395_1670	COG1349	DNA-binding transcription factor activity
VC395_1671	COG0584	glycerophosphoryl diester phosphodiesterase
VC395_1672	COG2731	YhcH YjgK YiaL family protein
VC395_1673	COG0251	oxidation-reduction process
VC395_1674	COG1609	Transcriptional regulator
VC395_1675	COG2723	6-phospho-beta-galactosidase activity
VC395_1677	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VC395_1678	COG0583	DNA-binding transcription factor activity
VC395_1682	COG1136	(ABC) transporter
VC395_1682	COG0577	efflux transmembrane transporter activity
VC395_1683	COG0577	efflux transmembrane transporter activity
VC395_1683	COG1136	(ABC) transporter
VC395_1684	COG4591	ABC-type transport system involved in lipoprotein release permease component
VC395_1684	COG1136	(ABC) transporter
VC395_1686	COG1294	oxidase, subunit
VC395_1687	COG1271	oxidase subunit
VC395_1695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VC395_1697	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VC395_1701	COG0753	catalase activity
VC395_1705	COG3527	Alpha-acetolactate decarboxylase
VC395_1708	COG2200	EAL domain
VC395_1708	COG2199	diguanylate cyclase activity
VC395_1709	COG3706	GGDEF domain
VC395_1710	COG2017	converts alpha-aldose to the beta-anomer
VC395_1711	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VC395_1712	COG1085	galactose-1-phosphate uridylyltransferase
VC395_1718	COG0784	Response regulator, receiver
VC395_1718	COG0835	chemotaxis
VC395_1720	COG4565	transcriptional regulatory protein
VC395_1721	COG3290	protein histidine kinase activity
VC395_1723	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_1727	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VC395_1728	COG3063	Type IV pilus biogenesis stability protein PilW
VC395_1731	COG1943	Transposase
VC395_1733	COG1451	nucleotide metabolic process
VC395_1735	COG0583	DNA-binding transcription factor activity
VC395_1739	COG1538	Outer membrane efflux protein
VC395_1741	COG0019	diaminopimelate decarboxylase activity
VC395_1742	COG1748	Saccharopine dehydrogenase
VC395_1744	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VC395_1747	COG4181	ATPase activity
VC395_1748	COG0534	Mate efflux family protein
VC395_1749	COG0702	epimerase
VC395_1751	COG2814	Major facilitator Superfamily
VC395_1752	COG1187	pseudouridine synthase activity
VC395_1753	COG1061	Type III restriction enzyme res subunit
VC395_1757	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VC395_1758	COG3706	GGDEF domain
VC395_1758	COG5001	Diguanylate cyclase
VC395_1758	COG4251	negative regulation of phosphorylation
VC395_1758	COG2203	Gaf domain
VC395_1760	COG0840	transmembrane signaling receptor activity
VC395_1772	COG2239	Acts as a magnesium transporter
VC395_1775	COG0814	amino acid
VC395_1776	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_1777	COG1131	(ABC) transporter
VC395_1778	COG0842	Transport permease protein
VC395_1780	COG3313	Fe-S protein
VC395_1782	COG4134	Bacterial extracellular solute-binding protein
VC395_1783	COG4135	transport system, permease component
VC395_1784	COG4136	ATPase activity
VC395_1785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VC395_1786	COG0564	pseudouridine synthase activity
VC395_1787	COG0733	neurotransmitter:sodium symporter activity
VC395_1789	COG0626	cystathionine gamma-synthase activity
VC395_1790	COG2818	Glycosylase
VC395_1793	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_1796	COG1842	Phage shock protein A
VC395_1797	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VC395_1798	COG0747	negative chemotaxis
VC395_1799	COG4168	peptide transport system, permease
VC395_1800	COG4171	peptide transport system, permease
VC395_1802	COG4172	Belongs to the ABC transporter superfamily
VC395_1805	COG1227	inorganic diphosphatase activity
VC395_1810	COG0243	molybdopterin cofactor binding
VC395_1811	COG3005	denitrification pathway
VC395_1812	COG4459	periplasmic nitrate reductase
VC395_1813	COG2116	formate transmembrane transporter activity
VC395_1815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VC395_1816	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VC395_1818	COG2917	probably involved in intracellular septation
VC395_1819	COG1607	acyl-coa hydrolase
VC395_1820	COG2350	Protein conserved in bacteria
VC395_1822	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VC395_1823	COG0583	DNA-binding transcription factor activity
VC395_1826	COG0612	Peptidase, M16
VC395_1827	COG5001	Diguanylate cyclase
VC395_1828	COG1032	radical SAM domain protein
VC395_1831	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VC395_1832	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VC395_1833	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VC395_1834	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VC395_1835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VC395_1836	COG0745	RESPONSE REGULATOR receiver
VC395_1837	COG3381	protein complex oligomerization
VC395_1838	COG1609	Transcriptional regulator
VC395_1839	COG3070	regulator of competence-specific genes
VC395_1843	COG0297	glycogen (starch) synthase activity
VC395_1844	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VC395_1846	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VC395_1848	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VC395_1851	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VC395_1852	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VC395_1853	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VC395_1854	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VC395_1855	COG1960	acyl-CoA dehydrogenase activity
VC395_1860	COG1012	belongs to the aldehyde dehydrogenase family
VC395_1861	COG1309	transcriptional regulator
VC395_1866	COG0668	transmembrane transport
VC395_1868	COG2995	paraquat-inducible protein a
VC395_1869	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VC395_1869	COG3008	intermembrane lipid transfer
VC395_1871	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_1873	COG0582	viral genome integration into host DNA
VC395_1875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VC395_1879	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VC395_1883	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VC395_1887	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VC395_1888	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VC395_1889	COG1737	Transcriptional regulator
VC395_1890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VC395_1891	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VC395_1892	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VC395_1893	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VC395_1895	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VC395_1896	COG1940	carbohydrate kinase activity
VC395_1897	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VC395_1898	COG4409	exo-alpha-(2->6)-sialidase activity
VC395_1900	COG2003	Belongs to the UPF0758 family
VC395_1905	COG3941	tape measure
VC395_1913	COG0488	(ABC) transporter
VC395_1929	COG0415	Belongs to the DNA photolyase family
VC395_1931	COG4628	conserved protein (DUF2132)
VC395_1932	COG3284	Transcriptional regulator
VC395_1934	COG1012	belongs to the aldehyde dehydrogenase family
VC395_1936	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_1937	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_1938	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_1940	COG2207	Transcriptional regulator
VC395_1941	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_1941	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_1941	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_1942	COG1482	cell wall glycoprotein biosynthetic process
VC395_1946	COG5002	protein histidine kinase activity
VC395_1946	COG0784	Response regulator, receiver
VC395_1948	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VC395_1950	COG2885	chlorophyll binding
VC395_1951	COG0823	Involved in the tonB-independent uptake of proteins
VC395_1954	COG0811	peptide transport
VC395_1956	COG3790	cyd operon protein YbgE
VC395_1957	COG4890	Cyd operon protein YbgT
VC395_1958	COG1294	oxidase, subunit
VC395_1959	COG1271	oxidase subunit
VC395_1960	COG2255	four-way junction helicase activity
VC395_1961	COG0632	four-way junction helicase activity
VC395_1962	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VC395_1963	COG0215	cysteine-tRNA ligase activity
VC395_1964	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VC395_1965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_1966	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VC395_1968	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VC395_1969	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VC395_1970	COG1199	ATP-dependent helicase activity
VC395_1971	COG0730	response to heat
VC395_1972	COG3923	Primosomal replication protein n
VC395_1974	COG0840	transmembrane signaling receptor activity
VC395_1975	COG0708	Exodeoxyribonuclease III
VC395_1976	COG4160	amino acid transport
VC395_1977	COG4215	(ABC) transporter
VC395_1981	COG1882	Formate acetyltransferase
VC395_1983	COG0840	transmembrane signaling receptor activity
VC395_1984	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VC395_1986	COG3013	Belongs to the UPF0304 family
VC395_1987	COG2766	serine protein kinase
VC395_1988	COG2718	Belongs to the UPF0229 family
VC395_1989	COG2719	SpoVR family
VC395_1990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VC395_1992	COG1663	tetraacyldisaccharide 4'-kinase activity
VC395_1993	COG1132	(ABC) transporter
VC395_1994	COG2333	competence protein COMEC
VC395_1994	COG0658	competence protein
VC395_1997	COG4591	ABC-type transport system involved in lipoprotein release permease component
VC395_1998	COG1136	(ABC) transporter
VC395_1999	COG4591	ABC-type transport system involved in lipoprotein release permease component
VC395_2001	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VC395_2005	COG1252	NADH dehydrogenase
VC395_2012	COG0537	adenosine 5'-monophosphoramidase activity
VC395_2015	COG2186	Transcriptional regulator
VC395_2016	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VC395_2017	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VC395_2018	COG1674	ftsk spoiiie
VC395_2020	COG0686	Belongs to the AlaDH PNT family
VC395_2022	COG0583	DNA-binding transcription factor activity
VC395_2026	COG0284	orotidine-5'-phosphate decarboxylase activity
VC395_2027	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VC395_2028	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VC395_2029	COG0776	regulation of translation
VC395_2030	COG0539	negative regulation of cytoplasmic translation
VC395_2031	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VC395_2032	COG1555	photosystem II stabilization
VC395_2033	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VC395_2034	COG0776	regulation of translation
VC395_2035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VC395_2036	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VC395_2037	COG0740	serine-type endopeptidase activity
VC395_2038	COG0544	peptidyl-prolyl cis-trans isomerase activity
VC395_2040	COG4191	Histidine kinase
VC395_2042	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VC395_2043	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VC395_2044	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VC395_2046	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VC395_2049	COG5001	Diguanylate cyclase
VC395_2049	COG3300	MHYT domain
VC395_2051	COG4589	Belongs to the CDS family
VC395_2057	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VC395_2060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_2065	COG0243	molybdopterin cofactor binding
VC395_2066	COG3005	denitrification pathway
VC395_2067	COG3469	chitinase activity
VC395_2067	COG3325	Belongs to the glycosyl hydrolase 18 family
VC395_2068	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VC395_2071	COG2951	lytic endotransglycosylase activity
VC395_2072	COG3100	YcgL domain-containing protein
VC395_2074	COG0850	regulation of cytokinetic process
VC395_2075	COG2894	cell division
VC395_2076	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VC395_2077	COG3015	lipoprotein NlpE involved in copper resistance
VC395_2081	COG0477	Major facilitator Superfamily
VC395_2082	COG0840	transmembrane signaling receptor activity
VC395_2083	COG1396	sequence-specific DNA binding
VC395_2085	COG3135	benzoate transporter
VC395_2087	COG1441	menaquinone biosynthetic process
VC395_2089	COG0596	Alpha beta hydrolase
VC395_2090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VC395_2091	COG1169	isochorismate synthase
VC395_2092	COG0436	Aminotransferase
VC395_2093	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VC395_2094	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VC395_2099	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VC395_2100	COG0318	PFAM AMP-dependent synthetase and ligase
VC395_2101	COG0596	Alpha beta hydrolase
VC395_2104	COG1214	PFAM Peptidase M22, glycoprotease
VC395_2105	COG1199	ATP-dependent helicase activity
VC395_2107	COG0788	formyltetrahydrofolate deformylase activity
VC395_2108	COG0446	pyridine nucleotide-disulphide oxidoreductase
VC395_2108	COG1902	pentaerythritol trinitrate reductase activity
VC395_2109	COG0616	signal peptide processing
VC395_2110	COG0252	asparaginase activity
VC395_2111	COG3139	Protein of unknown function (DUF1315)
VC395_2113	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_2115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VC395_2116	COG0676	glucose-6-phosphate 1-epimerase activity
VC395_2118	COG2226	methyltransferase
VC395_2121	COG0835	chemotaxis
VC395_2121	COG0784	Response regulator, receiver
VC395_2122	COG1940	carbohydrate kinase activity
VC395_2124	COG4667	esterase of the alpha-beta hydrolase superfamily
VC395_2127	COG0733	neurotransmitter:sodium symporter activity
VC395_2128	COG1263	PTS System
VC395_2128	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_2129	COG0084	hydrolase, TatD family'
VC395_2131	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VC395_2132	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VC395_2133	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VC395_2134	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VC395_2135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VC395_2136	COG1028	Short-chain dehydrogenase reductase Sdr
VC395_2137	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VC395_2138	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VC395_2139	COG0416	fatty acid biosynthetic process
VC395_2140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VC395_2141	COG1399	metal-binding, possibly nucleic acid-binding protein
VC395_2142	COG0424	maF-like protein
VC395_2143	COG0564	pseudouridine synthase activity
VC395_2145	COG1530	ribonuclease E activity
VC395_2146	COG0659	secondary active sulfate transmembrane transporter activity
VC395_2148	COG1012	belongs to the aldehyde dehydrogenase family
VC395_2148	COG1454	alcohol dehydrogenase
VC395_2150	COG2095	MarC family integral membrane protein
VC395_2151	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VC395_2152	COG1757	Na H antiporter
VC395_2154	COG3081	Nucleoid-associated protein
VC395_2156	COG3083	sulfuric ester hydrolase activity
VC395_2157	COG0123	including yeast histone deacetylase and acetoin utilization protein
VC395_2158	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VC395_2159	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VC395_2163	COG2853	Lipoprotein
VC395_2165	COG3088	subunit of a heme lyase
VC395_2165	COG4235	cytochrome complex assembly
VC395_2166	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VC395_2167	COG1138	Cytochrome C-type biogenesis protein
VC395_2168	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VC395_2170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VC395_2171	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VC395_2172	COG4133	protoheme IX ABC transporter activity
VC395_2174	COG0835	chemotaxis
VC395_2176	COG1192	Involved in chromosome partitioning
VC395_2177	COG2201	protein-glutamate methylesterase activity
VC395_2178	COG2198	Histidine kinase
VC395_2178	COG0643	Histidine kinase
VC395_2179	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VC395_2182	COG0455	bacterial-type flagellum organization
VC395_2185	COG2062	phosphohistidine phosphatase, SixA
VC395_2187	COG1025	Belongs to the peptidase M16 family
VC395_2189	COG0018	arginyl-trna synthetase
VC395_2193	COG1918	ferrous iron import across plasma membrane
VC395_2195	COG4977	sequence-specific DNA binding
VC395_2196	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VC395_2197	COG1121	(ABC) transporter
VC395_2198	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VC395_2200	COG0045	succinate-CoA ligase (ADP-forming) activity
VC395_2201	COG0508	dehydrogenase complex catalyzes the overall conversion of
VC395_2202	COG0567	Dehydrogenase, E1 component
VC395_2204	COG1053	succinate dehydrogenase
VC395_2205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VC395_2206	COG2009	succinate dehydrogenase
VC395_2207	COG0372	Belongs to the citrate synthase family
VC395_2208	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VC395_2210	COG0033	Phosphoglucomutase
VC395_2211	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VC395_2212	COG0596	Alpha beta hydrolase
VC395_2215	COG1346	cytolysis
VC395_2218	COG0583	DNA-binding transcription factor activity
VC395_2220	COG0735	belongs to the Fur family
VC395_2221	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VC395_2222	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VC395_2223	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VC395_2224	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VC395_2224	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VC395_2225	COG0431	NADPH-dependent FMN reductase
VC395_2227	COG3101	peptidyl-lysine hydroxylation
VC395_2229	COG2860	membrane
VC395_2230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VC395_2232	COG2890	protein-(glutamine-N5) methyltransferase activity
VC395_2235	COG1684	flagellar biosynthetic protein fliR
VC395_2236	COG1987	bacterial-type flagellum assembly
VC395_2241	COG1580	Controls the rotational direction of flagella during chemotaxis
VC395_2245	COG1317	bacterial-type flagellum organization
VC395_2246	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VC395_2248	COG1677	Flagellar hook-basal body complex protein FliE
VC395_2249	COG2204	response regulator
VC395_2250	COG4191	Histidine kinase
VC395_2251	COG2204	response regulator
VC395_2252	COG1516	flagellar protein fliS
VC395_2254	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VC395_2255	COG1334	flagellar protein FlaG
VC395_2256	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_2257	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_2258	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_2259	COG2837	iron assimilation
VC395_2264	COG1393	Belongs to the ArsC family
VC395_2266	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VC395_2267	COG1876	peptidase activity
VC395_2270	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VC395_2271	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VC395_2274	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VC395_2278	COG4783	chaperone-mediated protein folding
VC395_2279	COG1393	Belongs to the ArsC family
VC395_2285	COG2233	PERMEase
VC395_2286	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VC395_2288	COG0737	Belongs to the 5'-nucleotidase family
VC395_2289	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VC395_2290	COG2912	Transglutaminase-like superfamily
VC395_2291	COG3094	Invasion gene expression up-regulator, SirB
VC395_2292	COG2890	protein-(glutamine-N5) methyltransferase activity
VC395_2293	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VC395_2294	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VC395_2295	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VC395_2296	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VC395_2297	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VC395_2298	COG0193	aminoacyl-tRNA hydrolase activity
VC395_2299	COG0012	GTP binding
VC395_2301	COG1943	Transposase
VC395_2303	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_2304	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_2308	COG1705	Flagellar rod assembly protein muramidase FlgJ
VC395_2308	COG3951	Flagellar rod assembly protein muramidase FlgJ
VC395_2309	COG1706	bacterial-type flagellum-dependent cell motility
VC395_2310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VC395_2311	COG4786	Flagellar basal body rod
VC395_2312	COG4787	bacterial-type flagellum-dependent cell motility
VC395_2313	COG1749	Flagellar hook protein flgE
VC395_2314	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VC395_2315	COG1558	bacterial-type flagellum-dependent cell motility
VC395_2316	COG1815	bacterial-type flagellum-dependent cell motility
VC395_2317	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VC395_2318	COG0784	Response regulator, receiver
VC395_2318	COG0835	chemotaxis
VC395_2325	COG3433	isochorismatase activity
VC395_2325	COG2226	methyltransferase
VC395_2325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VC395_2326	COG2375	cellular response to nickel ion
VC395_2327	COG1629	transport
VC395_2327	COG4774	siderophore transport
VC395_2330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VC395_2331	COG2608	mercury ion transmembrane transporter activity
VC395_2331	COG2217	Heavy metal translocating P-type atpase
VC395_2336	COG3735	TraB family
VC395_2338	COG2840	Smr protein MutS2
VC395_2339	COG1187	pseudouridine synthase activity
VC395_2340	COG3706	GGDEF domain
VC395_2341	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VC395_2342	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VC395_2343	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VC395_2345	COG0121	glutamine amidotransferase
VC395_2346	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VC395_2347	COG1960	acyl-CoA dehydrogenase activity
VC395_2349	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VC395_2350	COG0328	RNA-DNA hybrid ribonuclease activity
VC395_2351	COG2226	methyltransferase
VC395_2352	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VC395_2353	COG0741	lytic transglycosylase activity
VC395_2353	COG1388	LysM domain
VC395_2355	COG0347	Belongs to the P(II) protein family
VC395_2356	COG3479	Phenolic acid decarboxylase
VC395_2358	COG0037	tRNA processing
VC395_2360	COG0825	malonyl-CoA metabolic process
VC395_2361	COG0587	DNA-directed DNA polymerase activity
VC395_2362	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VC395_2363	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_2364	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_2365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VC395_2366	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_2367	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VC395_2369	COG0750	zinc metalloprotease
VC395_2370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VC395_2371	COG0575	Belongs to the CDS family
VC395_2372	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VC395_2373	COG0233	cytoplasmic translational termination
VC395_2374	COG0528	UMP kinase activity
VC395_2375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VC395_2376	COG0052	Belongs to the universal ribosomal protein uS2 family
VC395_2377	COG0024	Methionine aminopeptidase
VC395_2378	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VC395_2381	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VC395_2382	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VC395_2383	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VC395_2384	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VC395_2387	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VC395_2387	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VC395_2388	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VC395_2389	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VC395_2390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VC395_2393	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VC395_2394	COG2252	PERMEase
VC395_2395	COG2195	Cleaves the N-terminal amino acid of tripeptides
VC395_2396	COG0189	ligase activity
VC395_2396	COG4067	protein conserved in archaea
VC395_2397	COG0189	ligase activity
VC395_2399	COG0733	neurotransmitter:sodium symporter activity
VC395_2401	COG3706	GGDEF domain
VC395_2403	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VC395_2405	COG1477	protein flavinylation
VC395_2406	COG2871	sodium ion transport
VC395_2407	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_2408	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_2409	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_2410	COG1805	sodium ion transport
VC395_2411	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_2412	COG0271	Belongs to the BolA IbaG family
VC395_2413	COG2813	Specifically methylates the guanine in position
VC395_2415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VC395_2416	COG2211	Major facilitator Superfamily
VC395_2418	COG1595	DNA-templated transcription, initiation
VC395_2421	COG3248	Nucleoside-binding outer membrane protein
VC395_2423	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VC395_2424	COG0693	protein deglycase activity
VC395_2425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VC395_2426	COG2166	iron-sulfur cluster assembly
VC395_2427	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VC395_2428	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VC395_2432	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VC395_2432	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VC395_2435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VC395_2436	COG1074	ATP-dependent DNA helicase activity
VC395_2438	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VC395_2442	COG3141	response to X-ray
VC395_2444	COG2171	N-acyltransferase activity
VC395_2447	COG0456	acetyltransferase
VC395_2448	COG0569	domain protein
VC395_2448	COG0189	ligase activity
VC395_2451	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_2453	COG3250	beta-galactosidase activity
VC395_2456	COG1022	Amp-dependent synthetase and ligase
VC395_2457	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VC395_2458	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VC395_2460	COG0560	Phosphoserine phosphatase
VC395_2462	COG0813	purine-nucleoside phosphorylase activity
VC395_2463	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VC395_2464	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VC395_2465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VC395_2467	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VC395_2468	COG0084	hydrolase, TatD family'
VC395_2471	COG1115	amino acid carrier protein
VC395_2474	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VC395_2475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VC395_2476	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VC395_2477	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VC395_2478	COG0083	homoserine kinase activity
VC395_2481	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VC395_2483	COG0745	RESPONSE REGULATOR receiver
VC395_2484	COG0784	Response regulator, receiver
VC395_2484	COG2198	Histidine kinase
VC395_2484	COG5002	protein histidine kinase activity
VC395_2485	COG4251	negative regulation of phosphorylation
VC395_2485	COG5001	Diguanylate cyclase
VC395_2485	COG2203	Gaf domain
VC395_2485	COG3706	GGDEF domain
VC395_2486	COG1242	4 iron, 4 sulfur cluster binding
VC395_2488	COG0069	glutamate synthase activity
VC395_2488	COG0070	glutamate synthase
VC395_2488	COG0067	glutamate synthase
VC395_2491	COG0067	glutamate synthase
VC395_2491	COG0070	glutamate synthase
VC395_2491	COG0069	glutamate synthase activity
VC395_2492	COG0493	'glutamate synthase
VC395_2494	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VC395_2496	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VC395_2497	COG2860	membrane
VC395_2498	COG0583	DNA-binding transcription factor activity
VC395_2499	COG0730	response to heat
VC395_2504	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VC395_2505	COG0505	Belongs to the CarA family
VC395_2506	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VC395_2507	COG0494	nUDIX hydrolase
VC395_2509	COG0653	protein targeting
VC395_2511	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VC395_2512	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VC395_2513	COG0849	cell division
VC395_2514	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VC395_2515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VC395_2516	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VC395_2517	COG0772	Belongs to the SEDS family
VC395_2518	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VC395_2519	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VC395_2520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VC395_2521	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VC395_2522	COG0768	penicillin binding
VC395_2523	COG3116	cell division
VC395_2524	COG0275	rRNA processing
VC395_2527	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_2528	COG0508	dehydrogenase complex catalyzes the overall conversion of
VC395_2529	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VC395_2530	COG2186	Transcriptional regulator
VC395_2531	COG0737	Belongs to the 5'-nucleotidase family
VC395_2532	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VC395_2533	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VC395_2534	COG4974	Belongs to the 'phage' integrase family
VC395_2535	COG0716	FMN binding
VC395_2539	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_2540	COG1459	type II secretion system
VC395_2542	COG0237	dephospho-CoA kinase activity
VC395_2543	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VC395_2544	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VC395_2545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VC395_2546	COG0187	DNA topoisomerase II activity
VC395_2547	COG3150	esterase
VC395_2549	COG3151	Protein conserved in bacteria
VC395_2550	COG0494	nUDIX hydrolase
VC395_2551	COG1538	Outer membrane efflux protein
VC395_2552	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VC395_2552	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VC395_2553	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VC395_2554	COG0840	transmembrane signaling receptor activity
VC395_2555	COG3025	triphosphatase activity
VC395_2556	COG1392	Phosphate transport regulator
VC395_2557	COG0306	phosphate transporter
VC395_2558	COG4991	sh3 domain protein
VC395_2560	COG3409	Peptidoglycan-binding domain 1 protein
VC395_2560	COG3267	Type II secretory pathway component ExeA
VC395_2561	COG0617	tRNA 3'-terminal CCA addition
VC395_2562	COG0148	phosphopyruvate hydratase activity
VC395_2563	COG0504	CTP synthase activity
VC395_2565	COG3956	TIGRFAM MazG family protein
VC395_2566	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VC395_2567	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VC395_2572	COG0736	holo-[acyl-carrier-protein] synthase activity
VC395_2573	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VC395_2574	COG1381	Involved in DNA repair and RecF pathway recombination
VC395_2575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VC395_2576	COG0571	ribonuclease III activity
VC395_2577	COG0681	Belongs to the peptidase S26 family
VC395_2578	COG0481	GTPase activity
VC395_2579	COG3086	response to oxidative stress
VC395_2580	COG3026	antisigma factor binding
VC395_2582	COG1595	DNA-templated transcription, initiation
VC395_2584	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VC395_2586	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VC395_2587	COG0354	folic acid binding
VC395_2589	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_2590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_2592	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VC395_2593	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VC395_2594	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VC395_2595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VC395_2596	COG0440	acetolactate synthase activity
VC395_2597	COG0028	Belongs to the TPP enzyme family
VC395_2598	COG1022	Amp-dependent synthetase and ligase
VC395_2599	COG0583	DNA-binding transcription factor activity
VC395_2604	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VC395_2605	COG0473	3-isopropylmalate dehydrogenase activity
VC395_2606	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VC395_2607	COG0066	3-isopropylmalate dehydratase activity
VC395_2611	COG3437	response regulator, receiver
VC395_2613	COG0795	lipopolysaccharide-transporting ATPase activity
VC395_2614	COG0795	lipopolysaccharide-transporting ATPase activity
VC395_2615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VC395_2616	COG2927	DNA polymerase III (CHI subunit)
VC395_2617	COG0525	valine-tRNA ligase activity
VC395_2618	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VC395_2619	COG0564	pseudouridine synthase activity
VC395_2620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VC395_2621	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VC395_2622	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VC395_2624	COG0540	Belongs to the ATCase OTCase family
VC395_2625	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VC395_2626	COG0251	oxidation-reduction process
VC395_2627	COG0204	Acyl-transferase
VC395_2628	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VC395_2629	COG5007	Belongs to the BolA IbaG family
VC395_2631	COG2854	intermembrane phospholipid transfer
VC395_2632	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VC395_2633	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VC395_2634	COG1127	ABC transporter
VC395_2637	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VC395_2637	COG0517	IMP dehydrogenase activity
VC395_2640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VC395_2641	COG1137	ATPase activity
VC395_2643	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VC395_2644	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_2646	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_2647	COG2239	Acts as a magnesium transporter
VC395_2648	COG0312	modulator of DNA gyrase
VC395_2649	COG3028	Belongs to the UPF0307 family
VC395_2650	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VC395_2651	COG1178	ABC-type Fe3 transport system permease component
VC395_2652	COG4143	(ABC) transporter
VC395_2654	COG0163	prenyltransferase activity
VC395_2655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VC395_2657	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VC395_2658	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VC395_2659	COG2105	PFAM AIG2 family protein
VC395_2661	COG0729	surface antigen
VC395_2662	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_2663	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VC395_2666	COG0577	efflux transmembrane transporter activity
VC395_2666	COG1136	(ABC) transporter
VC395_2670	COG0529	Catalyzes the synthesis of activated sulfate
VC395_2671	COG2895	sulfate adenylyltransferase (ATP) activity
VC395_2672	COG0175	sulfate reduction
VC395_2673	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VC395_2673	COG1648	precorrin-2 dehydrogenase activity
VC395_2674	COG0737	Belongs to the 5'-nucleotidase family
VC395_2676	COG0513	Belongs to the DEAD box helicase family
VC395_2677	COG2153	protein acetylation
VC395_2678	COG0697	spore germination
VC395_2679	COG3061	Opacity-associated protein A
VC395_2679	COG3266	domain, Protein
VC395_2680	COG0545	Peptidyl-prolyl cis-trans isomerase
VC395_2681	COG1943	Transposase
VC395_2683	COG0203	ribosomal protein L17
VC395_2684	COG0202	RNA polymerase activity
VC395_2685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VC395_2686	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VC395_2687	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VC395_2689	COG0201	protein transport
VC395_2690	COG0200	Binds to the 23S rRNA
VC395_2691	COG1841	ribosomal large subunit assembly
VC395_2692	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VC395_2693	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VC395_2694	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VC395_2695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VC395_2696	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VC395_2697	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VC395_2698	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VC395_2699	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VC395_2700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VC395_2701	COG0255	Belongs to the universal ribosomal protein uL29 family
VC395_2702	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VC395_2703	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VC395_2704	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VC395_2705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VC395_2706	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VC395_2707	COG0089	rRNA binding
VC395_2708	COG0088	Forms part of the polypeptide exit tunnel
VC395_2709	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VC395_2710	COG0051	transcription antitermination factor activity, RNA binding
VC395_2711	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VC395_2712	COG0557	exoribonuclease II activity
VC395_2713	COG3083	sulfuric ester hydrolase activity
VC395_2714	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VC395_2715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VC395_2717	COG1047	Peptidyl-prolyl cis-trans
VC395_2720	COG2249	NAD(P)H dehydrogenase (quinone) activity
VC395_2721	COG0488	(ABC) transporter
VC395_2723	COG0429	hydrolase of the alpha beta-hydrolase fold
VC395_2726	COG3954	Phosphoribulokinase
VC395_2727	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VC395_2729	COG1012	belongs to the aldehyde dehydrogenase family
VC395_2731	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VC395_2733	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VC395_2736	COG0180	Tryptophanyl-tRNA synthetase
VC395_2737	COG0546	phosphoglycolate phosphatase activity
VC395_2738	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VC395_2739	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VC395_2741	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VC395_2742	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VC395_2748	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VC395_2750	COG0678	peroxiredoxin activity
VC395_2750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VC395_2751	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_2754	COG0165	Argininosuccinate lyase
VC395_2755	COG0137	argininosuccinate synthase activity
VC395_2756	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VC395_2757	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VC395_2758	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VC395_2759	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VC395_2762	COG1045	serine acetyltransferase
VC395_2764	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VC395_2766	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VC395_2767	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VC395_2768	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VC395_2769	COG1053	succinate dehydrogenase
VC395_2770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VC395_2771	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VC395_2772	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VC395_2773	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VC395_2774	COG1509	lysine 2,3-aminomutase activity
VC395_2777	COG0459	protein refolding
VC395_2778	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VC395_2783	COG0149	triose-phosphate isomerase activity
VC395_2785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VC395_2786	COG1575	Belongs to the MenA family. Type 1 subfamily
VC395_2787	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VC395_2788	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VC395_2789	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VC395_2790	COG1609	Transcriptional regulator
VC395_2791	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VC395_2792	COG0254	rRNA binding
VC395_2794	COG0281	malic enzyme
VC395_2795	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VC395_2796	COG0626	cystathionine gamma-synthase activity
VC395_2797	COG0527	aspartate kinase activity
VC395_2797	COG0460	homoserine dehydrogenase
VC395_2798	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VC395_2799	COG3074	FtsZ-dependent cytokinesis
VC395_2801	COG1494	fructose-1,6-bisphosphatase
VC395_2802	COG0205	6-phosphofructokinase activity
VC395_2803	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VC395_2805	COG0745	RESPONSE REGULATOR receiver
VC395_2806	COG2205	protein histidine kinase activity
VC395_2808	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VC395_2809	COG3030	protein affecting phage T7 exclusion by the F plasmid
VC395_2810	COG3706	GGDEF domain
VC395_2811	COG1027	Aspartate ammonia-lyase
VC395_2812	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VC395_2814	COG4232	protein-disulfide reductase activity
VC395_2816	COG3263	regulation of cellular component size
VC395_2818	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VC395_2819	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VC395_2820	COG0194	GDP metabolic process
VC395_2821	COG1758	RNA polymerase activity
VC395_2822	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VC395_2823	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VC395_2824	COG2233	PERMEase
VC395_2826	COG0745	RESPONSE REGULATOR receiver
VC395_2827	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VC395_2828	COG2183	response to ionizing radiation
VC395_2830	COG0596	Alpha beta hydrolase
VC395_2831	COG1040	competence protein
VC395_2832	COG0316	Belongs to the HesB IscA family
VC395_2832	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VC395_2833	COG0494	nUDIX hydrolase
VC395_2834	COG1218	3'(2'),5'-bisphosphate nucleotidase
VC395_2836	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VC395_2837	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VC395_2838	COG3156	type II secretion system protein K
VC395_2839	COG4795	General secretion pathway protein
VC395_2840	COG2165	general secretion pathway protein
VC395_2841	COG2165	general secretion pathway protein
VC395_2842	COG2165	general secretion pathway protein
VC395_2843	COG1459	type II secretion system
VC395_2844	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_2846	COG3031	protein transport across the cell outer membrane
VC395_2847	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VC395_2848	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VC395_2850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VC395_2852	COG0456	acetyltransferase
VC395_2853	COG1490	D-aminoacyl-tRNA deacylase activity
VC395_2855	COG1660	Displays ATPase and GTPase activities
VC395_2858	COG0174	glutamine synthetase
VC395_2860	COG3852	Histidine kinase
VC395_2862	COG3300	MHYT domain
VC395_2862	COG5001	Diguanylate cyclase
VC395_2863	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VC395_A0006	COG0217	transcriptional regulatory protein
VC395_A0007	COG2084	Dehydrogenase
VC395_A0010	COG2909	trisaccharide binding
VC395_A0011	COG0058	SHG alpha-glucan phosphorylase activity
VC395_A0012	COG1640	4-alpha-glucanotransferase
VC395_A0013	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VC395_A0015	COG3501	Rhs element vgr protein
VC395_A0022	COG0471	metal ion transport
VC395_A0023	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VC395_A0031	COG0671	phosphoesterase, PA-phosphatase related
VC395_A0032	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VC395_A0034	COG1999	signal sequence binding
VC395_A0037	COG0786	glutamate:sodium symporter activity
VC395_A0042	COG1566	PFAM secretion protein HlyD family protein
VC395_A0044	COG3706	GGDEF domain
VC395_A0047	COG0813	purine-nucleoside phosphorylase activity
VC395_A0049	COG3272	Protein of unknown function (DUF1722)
VC395_A0051	COG0415	Belongs to the DNA photolyase family
VC395_A0052	COG1388	LysM domain
VC395_A0052	COG1376	ErfK ybiS ycfS ynhG family protein
VC395_A0054	COG0513	Belongs to the DEAD box helicase family
VC395_A0056	COG1770	oligopeptidase
VC395_A0063	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VC395_A0064	COG0573	inorganic phosphate transmembrane transporter activity
VC395_A0065	COG0581	inorganic phosphate transmembrane transporter activity
VC395_A0066	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VC395_A0071	COG0659	secondary active sulfate transmembrane transporter activity
VC395_A0073	COG0739	heme binding
VC395_A0074	COG3300	MHYT domain
VC395_A0074	COG5001	Diguanylate cyclase
VC395_A0075	COG0583	DNA-binding transcription factor activity
VC395_A0076	COG2814	Major facilitator Superfamily
VC395_A0081	COG1301	dicarboxylic acid transport
VC395_A0084	COG1342	Belongs to the UPF0251 family
VC395_A0091	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VC395_A0092	COG0673	inositol 2-dehydrogenase activity
VC395_A0094	COG2771	luxR family
VC395_A0094	COG2200	EAL domain
VC395_A0095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VC395_A0097	COG0564	pseudouridine synthase activity
VC395_A0116	COG3501	Rhs element vgr protein
VC395_A0120	COG1869	D-ribose catabolic process
VC395_A0121	COG1129	ABC transporter
VC395_A0122	COG1172	Belongs to the binding-protein-dependent transport system permease family
VC395_A0123	COG1879	ABC-type sugar transport system periplasmic component
VC395_A0124	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VC395_A0125	COG1609	Transcriptional regulator
VC395_A0127	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VC395_A0129	COG0584	glycerophosphoryl diester phosphodiesterase
VC395_A0130	COG2271	Major facilitator Superfamily
VC395_A0140	COG0579	oxidoreductase
VC395_A0143	COG0242	peptide deformylase activity
VC395_A0144	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VC395_A0144	COG1017	nitric oxide dioxygenase activity
VC395_A0145	COG1320	monovalent cation:proton antiporter activity
VC395_A0146	COG2212	antiporter activity
VC395_A0150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VC395_A0150	COG2111	Na H antiporter
VC395_A0152	COG0589	response to stress
VC395_A0153	COG0814	amino acid
VC395_A0154	COG3033	Beta-eliminating lyase
VC395_A0156	COG3530	Putative quorum-sensing-regulated virulence factor
VC395_A0158	COG5001	Diguanylate cyclase
VC395_A0158	COG5002	protein histidine kinase activity
VC395_A0159	COG1278	Cold shock
VC395_A0162	COG2304	oxidoreductase activity
VC395_A0166	COG0714	Associated with various cellular activities
VC395_A0167	COG0840	transmembrane signaling receptor activity
VC395_A0170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VC395_A0171	COG2195	Cleaves the N-terminal amino acid of tripeptides
VC395_A0173	COG3604	Transcriptional regulator
VC395_A0174	COG1017	nitric oxide dioxygenase activity
VC395_A0174	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VC395_A0175	COG1278	Cold shock
VC395_A0176	COG3036	rescue of stalled ribosome
VC395_A0182	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VC395_A0182	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VC395_A0183	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VC395_A0185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VC395_A0188	COG0516	GMP reductase activity
VC395_A0189	COG4974	Belongs to the 'phage' integrase family
VC395_A0210	COG4695	Portal protein
VC395_A0241	COG1943	Transposase
VC395_A0242	COG0513	Belongs to the DEAD box helicase family
VC395_A0243	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VC395_A0244	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VC395_A0245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VC395_A0247	COG3437	response regulator, receiver
VC395_A0247	COG0784	Response regulator, receiver
VC395_A0248	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VC395_A0248	COG4191	Histidine kinase
VC395_A0250	COG1757	Na H antiporter
VC395_A0251	COG2814	Major facilitator Superfamily
VC395_A0254	COG3706	GGDEF domain
VC395_A0255	COG3240	lipase activity
VC395_A0257	COG0840	transmembrane signaling receptor activity
VC395_A0258	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VC395_A0259	COG5380	lipid catabolic process
VC395_A0260	COG3291	Pkd domain containing protein
VC395_A0260	COG4412	M6 family metalloprotease domain protein
VC395_A0265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VC395_A0266	COG4605	iron ion homeostasis
VC395_A0267	COG4604	ABC transporter, ATP-binding protein
VC395_A0272	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VC395_A0276	COG0745	RESPONSE REGULATOR receiver
VC395_A0278	COG3623	hexulose-6-phosphate isomerase
VC395_A0279	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VC395_A0280	COG0561	phosphatase activity
VC395_A0286	COG3038	cytochrome b561
VC395_A0287	COG0366	Alpha amylase catalytic
VC395_A0294	COG0745	RESPONSE REGULATOR receiver
VC395_A0295	COG5002	protein histidine kinase activity
VC395_A0301	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VC395_A0304	COG2814	Major facilitator Superfamily
VC395_A0307	COG1686	Belongs to the peptidase S11 family
VC395_A0312	COG1943	Transposase
VC395_A0313	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VC395_A0313	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VC395_A0314	COG0509	glycine decarboxylation via glycine cleavage system
VC395_A0315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VC395_A0317	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VC395_A0319	COG3039	Transposase
VC395_A0324	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VC395_A0326	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VC395_A0327	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VC395_A0341	COG3549	Plasmid maintenance system killer
VC395_A0342	COG3093	addiction module antidote protein HigA
VC395_A0345	COG0384	phenazine biosynthesis protein PhzF
VC395_A0351	COG0346	lactoylglutathione lyase activity
VC395_A0364	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VC395_A0365	COG1280	lysine exporter protein (LysE YggA)
VC395_A0381	COG1619	proteins homologs of microcin C7 resistance protein MccF
VC395_A0395	COG3040	lipid binding
VC395_A0432	COG1619	proteins homologs of microcin C7 resistance protein MccF
VC395_A0436	COG3040	lipid binding
VC395_A0447	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VC395_A0448	COG4977	sequence-specific DNA binding
VC395_A0458	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VC395_A0459	COG2944	sequence-specific DNA binding
VC395_A0462	COG3039	Transposase
VC395_A0463	COG0110	maltose O-acetyltransferase activity
VC395_A0466	COG0346	lactoylglutathione lyase activity
VC395_A0503	COG1943	Transposase
VC395_A0515	COG0346	lactoylglutathione lyase activity
VC395_A0527	COG0484	heat shock protein binding
VC395_A0530	COG1716	ATPase activity
VC395_A0530	COG5001	Diguanylate cyclase
VC395_A0531	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VC395_A0533	COG4181	ATPase activity
VC395_A0534	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VC395_A0537	COG1984	allophanate hydrolase subunit 2
VC395_A0539	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VC395_A0540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VC395_A0541	COG0840	transmembrane signaling receptor activity
VC395_A0542	COG0814	amino acid
VC395_A0545	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VC395_A0546	COG0513	Belongs to the DEAD box helicase family
VC395_A0547	COG1309	transcriptional regulator
VC395_A0549	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VC395_A0550	COG0494	nUDIX hydrolase
VC395_A0552	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VC395_A0554	COG1126	abc transporter atp-binding protein
VC395_A0555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VC395_A0556	COG4215	(ABC) transporter
VC395_A0557	COG4160	amino acid transport
VC395_A0558	COG0583	DNA-binding transcription factor activity
VC395_A0562	COG3118	belongs to the thioredoxin family
VC395_A0563	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VC395_A0564	COG0247	lactate metabolic process
VC395_A0565	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VC395_A0566	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VC395_A0568	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VC395_A0569	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VC395_A0574	COG3132	Protein of unknown function, DUF480
VC395_A0575	COG2827	Endonuclease containing a URI domain
VC395_A0577	COG1879	ABC-type sugar transport system periplasmic component
VC395_A0578	COG0784	Response regulator, receiver
VC395_A0578	COG5002	protein histidine kinase activity
VC395_A0585	COG1492	cobalamin metabolic process
VC395_A0586	COG0725	ABC transporter, periplasmic molybdate-binding protein
VC395_A0587	COG4149	molybdate abc transporter
VC395_A0588	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VC395_A0594	COG1289	transmembrane transporter activity
VC395_A0595	COG0210	DNA helicase
VC395_A0598	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VC395_A0600	COG1335	isochorismatase
VC395_A0601	COG1803	Methylglyoxal synthase
VC395_A0602	COG1879	ABC-type sugar transport system periplasmic component
VC395_A0603	COG0784	Response regulator, receiver
VC395_A0603	COG2205	protein histidine kinase activity
VC395_A0603	COG2198	Histidine kinase
VC395_A0604	COG0469	pyruvate kinase activity
VC395_A0605	COG2271	Major facilitator Superfamily
VC395_A0606	COG1840	ABC-type Fe3 transport system, periplasmic component
VC395_A0607	COG4191	Histidine kinase
VC395_A0610	COG1979	alcohol dehydrogenase
VC395_A0613	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VC395_A0615	COG3706	GGDEF domain
VC395_A0619	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VC395_A0620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VC395_A0622	COG0183	Belongs to the thiolase family
VC395_A0624	COG3243	poly(R)-hydroxyalkanoic acid synthase
VC395_A0625	COG3842	ATPase activity
VC395_A0627	COG1840	ABC-type Fe3 transport system, periplasmic component
VC395_A0628	COG2271	Major facilitator Superfamily
VC395_A0629	COG3851	Histidine kinase
VC395_A0630	COG2197	response regulator
VC395_A0631	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VC395_A0634	COG0243	molybdopterin cofactor binding
VC395_A0636	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VC395_A0637	COG3850	Histidine kinase
VC395_A0638	COG2197	response regulator
VC395_A0639	COG1609	Transcriptional regulator
VC395_A0646	COG1760	l-serine dehydratase
VC395_A0647	COG3069	C4-dicarboxylate transmembrane transporter activity
VC395_A0649	COG0840	transmembrane signaling receptor activity
VC395_A0650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VC395_A0651	COG0545	Peptidyl-prolyl cis-trans isomerase
VC395_A0653	COG2885	chlorophyll binding
VC395_A0655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VC395_A0656	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VC395_A0657	COG1621	beta-fructofuranosidase activity
VC395_A0659	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_A0659	COG1263	PTS System
VC395_A0668	COG0446	pyridine nucleotide-disulphide oxidoreductase
VC395_A0670	COG0640	Transcriptional regulator
VC395_A0675	COG0778	Nitroreductase
VC395_A0676	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VC395_A0677	COG0583	DNA-binding transcription factor activity
VC395_A0682	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VC395_A0686	COG3039	Transposase
VC395_A0691	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VC395_A0692	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VC395_A0694	COG2390	Transcriptional regulator
VC395_A0695	COG2897	thiosulfate sulfurtransferase activity
VC395_A0697	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VC395_A0699	COG0302	gtp cyclohydrolase
VC395_A0700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_A0700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_A0701	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VC395_A0703	COG1970	mechanosensitive ion channel activity
VC395_A0705	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VC395_A0707	COG1011	Hydrolase
VC395_A0708	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VC395_A0709	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VC395_A0711	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VC395_A0713	COG3842	ATPase activity
VC395_A0723	COG4166	transmembrane transport
VC395_A0724	COG4174	ABC transporter (Permease)
VC395_A0725	COG4239	(ABC) transporter, permease
VC395_A0726	COG4172	Belongs to the ABC transporter superfamily
VC395_A0727	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VC395_A0730	COG0625	glutathione transferase activity
VC395_A0734	COG2050	protein possibly involved in aromatic compounds catabolism
VC395_A0739	COG1629	transport
VC395_A0739	COG4771	TonB-dependent receptor
VC395_A0740	COG0583	DNA-binding transcription factor activity
VC395_A0741	COG0045	succinate-CoA ligase (ADP-forming) activity
VC395_A0741	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VC395_A0741	COG1042	CoA-binding domain protein
VC395_A0743	COG1181	Belongs to the D-alanine--D-alanine ligase family
VC395_A0745	COG0023	Translation Initiation Factor
VC395_A0748	COG4128	Pfam Zonular occludens toxin
VC395_A0759	COG0745	RESPONSE REGULATOR receiver
VC395_A0761	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VC395_A0762	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VC395_A0765	COG3706	GGDEF domain
VC395_A0775	COG2824	Alkylphosphonate utilization operon protein PhnA
VC395_A0778	COG0861	Integral membrane protein TerC family
VC395_A0779	COG0737	Belongs to the 5'-nucleotidase family
VC395_A0780	COG3593	DNA synthesis involved in DNA repair
VC395_A0782	COG0583	DNA-binding transcription factor activity
VC395_A0784	COG2116	formate transmembrane transporter activity
VC395_A0785	COG2353	YceI-like domain
VC395_A0786	COG3038	cytochrome b561
VC395_A0788	COG2200	EAL domain
VC395_A0790	COG0586	Pfam SNARE associated Golgi protein
VC395_A0791	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VC395_A0793	COG2205	protein histidine kinase activity
VC395_A0794	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VC395_A0794	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VC395_A0794	COG0674	pyruvate-flavodoxin oxidoreductase activity
VC395_A0794	COG1013	pyruvate-flavodoxin oxidoreductase activity
VC395_A0795	COG3158	transport of potassium into the cell
VC395_A0797	COG0523	cobalamin synthesis protein
VC395_A0798	COG0038	chloride channel
VC395_A0801	COG0156	8-amino-7-oxononanoate synthase activity
VC395_A0802	COG2205	protein histidine kinase activity
VC395_A0802	COG0784	Response regulator, receiver
VC395_A0803	COG0419	ATPase involved in DNA repair
VC395_A0805	COG1609	Transcriptional regulator
VC395_A0806	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_A0806	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_A0807	COG1105	Belongs to the carbohydrate kinase PfkB family
VC395_A0808	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_A0808	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VC395_A0808	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_A0809	COG0189	ligase activity
VC395_A0809	COG4067	protein conserved in archaea
VC395_A0811	COG0602	queuosine metabolic process
VC395_A0812	COG1328	CTP reductase activity
VC395_A0822	COG0546	phosphoglycolate phosphatase activity
VC395_A0825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VC395_A0826	COG1368	sulfuric ester hydrolase activity
VC395_A0828	COG0513	Belongs to the DEAD box helicase family
VC395_A0829	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VC395_A0831	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VC395_A0833	COG3046	protein related to deoxyribodipyrimidine photolyase
VC395_A0835	COG3397	chitin binding
VC395_A0836	COG3227	Zinc metalloprotease (Elastase)
VC395_A0838	COG0010	Belongs to the arginase family
VC395_A0839	COG1166	arginine decarboxylase activity
VC395_A0842	COG2239	Acts as a magnesium transporter
VC395_A0843	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VC395_A0844	COG0459	protein refolding
VC395_A0846	COG0527	aspartate kinase activity
VC395_A0847	COG0662	Cupin 2, conserved barrel domain protein
VC395_A0848	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VC395_A0849	COG0456	acetyltransferase
VC395_A0851	COG2154	pterin-4-alpha-carbinolamine dehydratase
VC395_A0852	COG3186	Phenylalanine-4-hydroxylase
VC395_A0853	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VC395_A0856	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VC395_A0857	COG0583	DNA-binding transcription factor activity
VC395_A0860	COG2171	N-acyltransferase activity
VC395_A0861	COG1253	flavin adenine dinucleotide binding
VC395_A0862	COG1765	OsmC-like protein
VC395_A0871	COG0531	amino acid
VC395_A0874	COG3279	Response regulator of the LytR AlgR family
VC395_A0875	COG3275	phosphorelay sensor kinase activity
VC395_A0878	COG1136	(ABC) transporter
VC395_A0878	COG0577	efflux transmembrane transporter activity
VC395_A0879	COG1136	(ABC) transporter
VC395_A0883	COG4989	oxidoreductase activity
VC395_A0884	COG0366	Alpha amylase catalytic
VC395_A0886	COG2067	long-chain fatty acid transport protein
VC395_A0887	COG2267	carboxylic ester hydrolase activity
VC395_A0889	COG3227	Zinc metalloprotease (Elastase)
VC395_A0891	COG3047	cAMP biosynthetic process
VC395_A0894	COG1686	Belongs to the peptidase S11 family
VC395_A0895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VC395_A0896	COG1271	oxidase subunit
VC395_A0897	COG1294	oxidase, subunit
VC395_A0899	COG3048	D-serine ammonia-lyase activity
VC395_A0900	COG0583	DNA-binding transcription factor activity
VC395_A0910	COG1063	alcohol dehydrogenase
VC395_A0912	COG0693	protein deglycase activity
VC395_A0915	COG0346	lactoylglutathione lyase activity
VC395_A0921	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VC395_A0922	COG0363	glucosamine-6-phosphate deaminase activity
VC395_A0923	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VC395_A0928	COG1929	Belongs to the glycerate kinase type-1 family
VC395_A0929	COG2610	gluconate transmembrane transporter activity
VC395_A0930	COG3835	regulator
VC395_A0932	COG0748	coenzyme F420 binding
VC395_A0933	COG3721	Heme iron utilization protein
VC395_A0935	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VC395_A0936	COG0811	peptide transport
VC395_A0937	COG0848	biopolymer transport protein
VC395_A0938	COG4558	Periplasmic binding protein
VC395_A0939	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VC395_A0940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VC395_A0949	COG3217	Mosc domain protein beta barrel domain protein
VC395_A0949	COG0633	Ferredoxin
VC395_A0949	COG3217	Mosc domain protein beta barrel domain protein
VC395_A0949	COG0633	Ferredoxin
VC395_A0950	COG0418	dihydroorotase activity
VC395_A0952	COG3152	Membrane
VC395_A0954	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VC395_A0955	COG2354	Protein conserved in bacteria
VC395_A0956	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VC395_A0958	COG1278	Cold shock
VC395_A0964	COG3706	GGDEF domain
VC395_A0965	COG1349	DNA-binding transcription factor activity
VC395_A0968	COG3833	ABC-type maltose transport systems, permease component
VC395_A0969	COG1175	transmembrane transport
VC395_A0971	COG3842	ATPase activity
VC395_A0972	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VC395_A0976	COG0393	Putative heavy-metal-binding
VC395_A0977	COG2197	response regulator
VC395_A0978	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VC395_A0979	COG0784	Response regulator, receiver
VC395_A0979	COG0835	chemotaxis
VC395_A0980	COG1846	Transcriptional regulator
VC395_A0981	COG3706	GGDEF domain
VC395_A0989	COG0583	DNA-binding transcription factor activity
VC395_A0990	COG5001	Diguanylate cyclase
VC395_A0994	COG1741	Belongs to the pirin family
VC395_A0995	COG3123	guanosine phosphorylase activity
VC395_A0997	COG2211	Major facilitator Superfamily
VC395_A0999	COG0840	transmembrane signaling receptor activity
VC395_A1000	COG1067	ATP-dependent peptidase activity
VC395_A1002	COG4172	Belongs to the ABC transporter superfamily
VC395_A1006	COG0583	DNA-binding transcription factor activity
VC395_A1007	COG1620	l-lactate permease
VC395_A1008	COG1304	FMN binding
VC395_A1010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VC395_A1012	COG0840	transmembrane signaling receptor activity
VC395_A1014	COG0513	Belongs to the DEAD box helicase family
VC395_A1015	COG0583	DNA-binding transcription factor activity
VC395_A1017	COG1902	pentaerythritol trinitrate reductase activity
VC395_A1020	COG1132	(ABC) transporter
VC395_A1022	COG1902	pentaerythritol trinitrate reductase activity
VC395_A1024	COG1280	lysine exporter protein (LysE YggA)
VC395_A1025	COG2207	Transcriptional regulator
VC395_A1029	COG1846	Transcriptional regulator
VC395_A1030	COG1764	response to oxidative stress
VC395_A1032	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VC395_A1034	COG0697	spore germination
VC395_A1036	COG0700	Nucleoside recognition
VC395_A1037	COG3366	ferrous iron transmembrane transporter activity
VC395_A1039	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VC395_A1041	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VC395_A1042	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VC395_A1043	COG2259	Doxx family
VC395_A1048	COG0363	glucosamine-6-phosphate deaminase activity
VC395_A1051	COG4580	involved in the transport of maltose and maltodextrins
VC395_A1054	COG0840	transmembrane signaling receptor activity
VC395_A1057	COG0840	transmembrane signaling receptor activity
VC395_A1059	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VC395_A1060	COG1126	abc transporter atp-binding protein
VC395_A1062	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VC395_A1063	COG4597	amino acid ABC transporter
VC395_A1064	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VC395_A1066	COG0739	heme binding
VC395_A1068	COG2213	PTS system mannitol-specific
VC395_A1068	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_A1069	COG0246	Mannitol dehydrogenase
VC395_A1070	COG3722	fumarate hydratase activity
VC395_A1071	COG0673	inositol 2-dehydrogenase activity
VC395_A1077	COG2910	NAD(P)H-binding
VC395_A1079	COG0840	transmembrane signaling receptor activity
VC395_A1080	COG4221	oxidoreductase activity
VC395_A1082	COG1901	pseudouridine methyltransferase
VC395_A1083	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VC395_A1084	COG0531	amino acid
VC395_A1085	COG1982	Orn Lys Arg decarboxylase major
VC395_A1093	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VC395_A1099	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VC395_A1101	COG0259	pyridoxamine-phosphate oxidase activity
VC395_A1107	COG0745	RESPONSE REGULATOR receiver
VC395_A1111	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VC395_A1112	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VC395_A1113	COG0840	transmembrane signaling receptor activity
VC395_A1114	COG0835	chemotaxis
VC395_A1115	COG0835	chemotaxis
VC395_A1116	COG0643	Histidine kinase
VC395_A1116	COG2198	Histidine kinase
VC395_A1120	COG0601	transmembrane transport
VC395_A1121	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VC395_A1125	COG0642	Histidine kinase
VC395_A1126	COG0745	RESPONSE REGULATOR receiver
VC395_A1132	COG1444	tRNA N-acetyltransferase activity
VC395_A1133	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine