locus-tag	class	description
F0315_00020	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_00055	COG4657	Part of a membrane complex involved in electron transport
F0315_00060	COG2878	Part of a membrane complex involved in electron transport
F0315_00065	COG4656	Part of a membrane complex involved in electron transport
F0315_00070	COG4658	electron transport chain
F0315_00075	COG4659	FMN binding
F0315_00080	COG4660	Part of a membrane complex involved in electron transport
F0315_00085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F0315_00090	COG0346	lactoylglutathione lyase activity
F0315_00105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0315_00110	COG2056	Na+-H+ antiporter family
F0315_00115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F0315_00120	COG1286	toxin biosynthetic process
F0315_00125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
F0315_00130	COG0285	dihydrofolate synthase activity
F0315_00135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0315_00140	COG0101	tRNA pseudouridine synthase activity
F0315_00150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0315_00155	COG2190	(PTS) system
F0315_00155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_00155	COG1263	PTS System
F0315_00160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0315_00165	COG1846	Transcriptional regulator
F0315_00165	COG1940	carbohydrate kinase activity
F0315_00170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0315_00170	COG4651	solute:proton antiporter activity
F0315_00175	COG0367	asparagine synthase
F0315_00185	COG3104	oligopeptide transport
F0315_00190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0315_00195	COG0563	adenylate kinase activity
F0315_00200	COG0326	Molecular chaperone. Has ATPase activity
F0315_00205	COG3710	Transcriptional regulator
F0315_00220	COG0622	Phosphoesterase
F0315_00225	COG1090	epimerase
F0315_00230	COG0300	oxidoreductase activity
F0315_00240	COG3118	belongs to the thioredoxin family
F0315_00245	COG0330	HflC and HflK could
F0315_00250	COG1585	Membrane protein implicated in regulation of membrane protease activity
F0315_00255	COG0789	Transcriptional regulator
F0315_00275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0315_00280	COG3115	cell septum assembly
F0315_00285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
F0315_00290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0315_00300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_00310	COG2190	(PTS) system
F0315_00315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0315_00320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0315_00325	COG1702	phosphate starvation-inducible protein PhoH
F0315_00330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0315_00335	COG4535	Mg2 and Co2 transporter CorC
F0315_00340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F0315_00345	COG2888	peptidyl-tyrosine sulfation
F0315_00350	COG0495	leucyl-tRNA aminoacylation
F0315_00355	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F0315_00360	COG1466	dna polymerase III delta subunit
F0315_00365	COG0799	negative regulation of ribosome biogenesis
F0315_00370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F0315_00375	COG0768	penicillin binding
F0315_00380	COG0772	Belongs to the SEDS family
F0315_00385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0315_00390	COG1686	Belongs to the peptidase S11 family
F0315_00395	COG2921	Belongs to the UPF0250 family
F0315_00400	COG0321	lipoyl(octanoyl) transferase activity
F0315_00405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0315_00420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0315_00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0315_00485	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F0315_00495	COG0438	transferase activity, transferring glycosyl groups
F0315_00505	COG1045	serine acetyltransferase
F0315_00525	COG0110	maltose O-acetyltransferase activity
F0315_00530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0315_00535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0315_00540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0315_00545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_00585	COG2205	protein histidine kinase activity
F0315_00590	COG0745	RESPONSE REGULATOR receiver
F0315_00595	COG0366	Alpha amylase catalytic
F0315_00600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_00600	COG1263	PTS System
F0315_00605	COG1609	Transcriptional regulator
F0315_00610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0315_00615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0315_00620	COG2011	ABC-type metal ion transport system permease component
F0315_00625	COG1464	Belongs to the NlpA lipoprotein family
F0315_00630	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
F0315_00640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0315_00640	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0315_00650	COG3706	GGDEF domain
F0315_00655	COG1611	Belongs to the LOG family
F0315_00660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0315_00665	COG2363	Small membrane protein
F0315_00670	COG0583	DNA-binding transcription factor activity
F0315_00675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0315_00675	COG0301	tRNA thio-modification
F0315_00685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F0315_00690	COG1722	exodeoxyribonuclease VII activity
F0315_00695	COG0142	geranyltranstransferase activity
F0315_00700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0315_00705	COG0564	pseudouridine synthase activity
F0315_00735	COG1671	Belongs to the UPF0178 family
F0315_00740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0315_00745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0315_00750	COG0254	rRNA binding
F0315_00755	COG1720	tRNA m6t6A37 methyltransferase activity
F0315_00760	COG0442	prolyl-tRNA aminoacylation
F0315_00780	COG0047	phosphoribosylformylglycinamidine synthase activity
F0315_00780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0315_00790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F0315_00795	COG0590	tRNA wobble adenosine to inosine editing
F0315_00800	COG0583	DNA-binding transcription factor activity
F0315_00810	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F0315_00815	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0315_00850	COG0484	heat shock protein binding
F0315_00855	COG0443	Heat shock 70 kDa protein
F0315_00865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F0315_00880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0315_00885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0315_00890	COG0497	DNA recombination
F0315_00895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_00900	COG2914	Belongs to the UPF0125 (RnfH) family
F0315_00905	COG2867	negative regulation of translational initiation
F0315_00910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0315_00920	COG0582	viral genome integration into host DNA
F0315_00950	COG1518	maintenance of DNA repeat elements
F0315_00965	COG3501	Rhs element vgr protein
F0315_01015	COG2003	Belongs to the UPF0758 family
F0315_01050	COG0582	viral genome integration into host DNA
F0315_01100	COG0732	type I restriction modification DNA specificity domain
F0315_01180	COG1061	Type III restriction enzyme res subunit
F0315_01195	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F0315_01205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F0315_01210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0315_01215	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F0315_01220	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
F0315_01225	COG3051	citrate lyase alpha subunit
F0315_01230	COG2301	Belongs to the HpcH HpaI aldolase family
F0315_01235	COG3052	prosthetic group binding
F0315_01240	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F0315_01250	COG3630	sodium ion export across plasma membrane
F0315_01255	COG0511	ligase activity, forming carbon-carbon bonds
F0315_01255	COG5016	pyruvate
F0315_01260	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0315_01270	COG4565	transcriptional regulatory protein
F0315_01280	COG2200	EAL domain
F0315_01290	COG0583	DNA-binding transcription factor activity
F0315_01295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0315_01300	COG1115	amino acid carrier protein
F0315_01305	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F0315_01310	COG0583	DNA-binding transcription factor activity
F0315_01315	COG1584	GPR1 FUN34 yaaH family protein
F0315_01325	COG0519	Catalyzes the synthesis of GMP from XMP
F0315_01325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0315_01330	COG0516	GMP reductase activity
F0315_01330	COG0517	IMP dehydrogenase activity
F0315_01335	COG1570	exodeoxyribonuclease VII activity
F0315_01350	COG1160	GTP binding
F0315_01355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_01360	COG2976	Protein conserved in bacteria
F0315_01365	COG0124	histidyl-tRNA synthetase
F0315_01370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0315_01375	COG1426	Protein conserved in bacteria
F0315_01385	COG0105	UTP biosynthetic process
F0315_01390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0315_01395	COG2975	iron-sulfur cluster assembly
F0315_01400	COG0633	Ferredoxin
F0315_01410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0315_01420	COG0822	iron-sulfur transferase activity
F0315_01430	COG1959	2 iron, 2 sulfur cluster binding
F0315_01440	COG0483	inositol monophosphate 1-phosphatase activity
F0315_01445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_01450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_01455	COG1862	Preprotein translocase
F0315_01460	COG0343	queuine tRNA-ribosyltransferase activity
F0315_01470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0315_01475	COG0517	IMP dehydrogenase activity
F0315_01485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0315_01490	COG0583	DNA-binding transcription factor activity
F0315_01495	COG0450	alkyl hydroperoxide reductase
F0315_01500	COG3142	Participates in the control of copper homeostasis
F0315_01515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0315_01520	COG0581	inorganic phosphate transmembrane transporter activity
F0315_01530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0315_01535	COG0248	Ppx GppA phosphatase
F0315_01545	COG5002	protein histidine kinase activity
F0315_01550	COG0745	RESPONSE REGULATOR receiver
F0315_01555	COG2974	May be involved in recombination
F0315_01565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0315_01620	COG0542	response to heat
F0315_01630	COG0564	pseudouridine synthase activity
F0315_01635	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_01640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0315_01645	COG1605	Chorismate mutase
F0315_01645	COG0077	Prephenate dehydratase
F0315_01650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0315_01655	COG5001	Diguanylate cyclase
F0315_01660	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
F0315_01665	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
F0315_01675	COG0488	(ABC) transporter
F0315_01685	COG0287	Prephenate dehydrogenase
F0315_01685	COG1605	Chorismate mutase
F0315_01690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0315_01695	COG3275	phosphorelay sensor kinase activity
F0315_01700	COG3279	Response regulator of the LytR AlgR family
F0315_01705	COG1472	Belongs to the glycosyl hydrolase 3 family
F0315_01710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F0315_01715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0315_01730	COG1966	Carbon starvation protein
F0315_01735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0315_01740	COG1047	Peptidyl-prolyl cis-trans
F0315_01745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0315_01750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0315_01755	COG0196	riboflavin kinase activity
F0315_01760	COG0728	peptidoglycan biosynthetic process
F0315_01765	COG0268	Binds directly to 16S ribosomal RNA
F0315_01770	COG0640	Transcriptional regulator
F0315_01775	COG0583	DNA-binding transcription factor activity
F0315_01780	COG1283	sodium-dependent phosphate transmembrane transporter activity
F0315_01785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0315_01790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0315_01795	COG0730	response to heat
F0315_01800	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
F0315_01805	COG0494	nUDIX hydrolase
F0315_01810	COG3066	DNA modification
F0315_01815	COG0667	Aldo Keto reductase
F0315_01825	COG2204	response regulator
F0315_01830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0315_01845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F0315_01850	COG0513	Belongs to the DEAD box helicase family
F0315_01855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F0315_01875	COG3153	acetyltransferase
F0315_01910	COG4785	May be involved in cell division
F0315_01915	COG1185	polyribonucleotide nucleotidyltransferase activity
F0315_01920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0315_01925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F0315_01930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0315_01935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0315_01940	COG0195	Participates in both transcription termination and antitermination
F0315_01945	COG0779	Required for maturation of 30S ribosomal subunits
F0315_01960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0315_01965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0315_01970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0315_01975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0315_01980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F0315_01985	COG1534	Rna-binding protein
F0315_01990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0315_01995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0315_02000	COG2027	D-alanyl-D-alanine carboxypeptidase
F0315_02005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0315_02010	COG0739	heme binding
F0315_02015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_02025	COG0316	Belongs to the HesB IscA family
F0315_02030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0315_02040	COG0628	permease
F0315_02045	COG2813	Specifically methylates the guanine in position
F0315_02055	COG0747	negative chemotaxis
F0315_02065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_02070	COG0444	Belongs to the ABC transporter superfamily
F0315_02075	COG4608	Belongs to the ABC transporter superfamily
F0315_02085	COG2971	BadF BadG BcrA BcrD
F0315_02100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0315_02105	COG3842	ATPase activity
F0315_02115	COG1840	ABC-type Fe3 transport system, periplasmic component
F0315_02120	COG0004	ammonium transporteR
F0315_02125	COG0347	Belongs to the P(II) protein family
F0315_02130	COG3112	Uncharacterised protein family (UPF0231)
F0315_02135	COG1049	propionate catabolic process, 2-methylcitrate cycle
F0315_02140	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0315_02150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0315_02155	COG1643	Atp-dependent helicase
F0315_02165	COG1489	DNA binding
F0315_02170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F0315_02175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0315_02185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0315_02190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0315_02195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0315_02200	COG0842	Transport permease protein
F0315_02205	COG1131	(ABC) transporter
F0315_02210	COG0659	secondary active sulfate transmembrane transporter activity
F0315_02215	COG0288	reversible hydration of carbon dioxide
F0315_02230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F0315_02235	COG3107	peptidoglycan biosynthetic process
F0315_02240	COG0792	nuclease activity
F0315_02245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0315_02250	COG2823	Periplasmic or secreted lipoprotein
F0315_02255	COG2969	positive regulation of protein catabolic process
F0315_02260	COG0625	glutathione transferase activity
F0315_02265	COG2857	Cytochrome c1
F0315_02270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F0315_02275	COG0723	plastoquinol--plastocyanin reductase activity
F0315_02280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0315_02285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0315_02290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F0315_02300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0315_02305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0315_02310	COG0335	large ribosomal subunit rRNA binding
F0315_02315	COG0336	Belongs to the RNA methyltransferase TrmD family
F0315_02320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0315_02325	COG0228	four-way junction DNA binding
F0315_02330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0315_02335	COG4137	Cytochrome C assembly protein
F0315_02340	COG4536	flavin adenine dinucleotide binding
F0315_02345	COG1854	S-ribosylhomocysteine lyase activity
F0315_02350	COG2918	glutathione biosynthetic process
F0315_02355	COG0612	Peptidase, M16
F0315_02360	COG1238	metal cluster binding
F0315_02370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0315_02375	COG5016	pyruvate
F0315_02375	COG0511	ligase activity, forming carbon-carbon bonds
F0315_02380	COG3630	sodium ion export across plasma membrane
F0315_02425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F0315_02430	COG0527	aspartate kinase activity
F0315_02435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0315_02440	COG2137	regulation of response to DNA damage stimulus
F0315_02445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0315_02450	COG1546	Belongs to the CinA family
F0315_02455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F0315_02460	COG4208	sulfate ABC transporter
F0315_02465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F0315_02480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F0315_02485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0315_02490	COG1388	LysM domain
F0315_02490	COG4942	peptidase
F0315_02495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0315_02500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F0315_02505	COG0585	pseudouridine synthase activity
F0315_02510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0315_02515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0315_02520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F0315_02525	COG1968	undecaprenyl-diphosphatase activity
F0315_02530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0315_02535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0315_02545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F0315_02555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0315_02560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F0315_02565	COG1610	YqeY-like protein
F0315_02570	COG0358	DNA primase activity
F0315_02575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0315_02590	COG0582	viral genome integration into host DNA
F0315_02620	COG2003	Belongs to the UPF0758 family
F0315_02660	COG1479	Protein of unknown function DUF262
F0315_02700	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_02735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F0315_02810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0315_02815	COG1349	DNA-binding transcription factor activity
F0315_02820	COG0469	pyruvate kinase activity
F0315_02830	COG0583	DNA-binding transcription factor activity
F0315_02835	COG1279	arginine transmembrane transporter activity
F0315_02840	COG0668	transmembrane transport
F0315_02845	COG0191	fructose-bisphosphate aldolase activity
F0315_02850	COG0126	phosphoglycerate kinase activity
F0315_02855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0315_02860	COG4771	TonB-dependent receptor
F0315_02865	COG0583	DNA-binding transcription factor activity
F0315_02870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0315_02875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0315_02880	COG3091	SprT-like family
F0315_02885	COG2356	endonuclease I
F0315_02890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F0315_02895	COG0189	ligase activity
F0315_02900	COG1678	Uncharacterized ACR, COG1678
F0315_02905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0315_02910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0315_02935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0315_02940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0315_02945	COG0762	integral membrane protein
F0315_02960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F0315_02965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0315_02970	COG2066	Belongs to the glutaminase family
F0315_02975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0315_02980	COG1194	a g-specific adenine glycosylase
F0315_02985	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F0315_02990	COG0741	lytic transglycosylase activity
F0315_03045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0315_03050	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0315_03055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0315_03060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0315_03065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0315_03070	COG2967	ApaG domain
F0315_03075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0315_03090	COG3610	response to peptide
F0315_03095	COG2966	Psort location CytoplasmicMembrane, score
F0315_03100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0315_03105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0315_03110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0315_03115	COG0142	geranyltranstransferase activity
F0315_03120	COG0531	amino acid
F0315_03125	COG0039	L-malate dehydrogenase activity
F0315_03130	COG1438	arginine binding
F0315_03150	COG0589	response to stress
F0315_03175	COG2235	arginine
F0315_03180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0315_03190	COG0312	modulator of DNA gyrase
F0315_03195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0315_03200	COG3164	Protein of unknown function
F0315_03205	COG1530	ribonuclease E activity
F0315_03210	COG0424	maF-like protein
F0315_03215	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F0315_03220	COG1792	Involved in formation and maintenance of cell shape
F0315_03225	COG1077	Cell shape determining protein MreB Mrl
F0315_03270	COG1459	type II secretion system
F0315_03275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0315_03285	COG3409	Peptidoglycan-binding domain 1 protein
F0315_03285	COG3267	Type II secretory pathway component ExeA
F0315_03310	COG2199	diguanylate cyclase activity
F0315_03310	COG2200	EAL domain
F0315_03385	COG0629	single-stranded DNA binding
F0315_03400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0315_03410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0315_03415	COG0527	aspartate kinase activity
F0315_03420	COG0646	methionine synthase
F0315_03420	COG1410	methionine synthase
F0315_03490	COG0175	sulfate reduction
F0315_03495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0315_03500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0315_03525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0315_03530	COG0735	belongs to the Fur family
F0315_03545	COG0166	Belongs to the GPI family
F0315_03550	COG0432	Pfam Uncharacterised protein family UPF0047
F0315_03555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0315_03560	COG0305	Participates in initiation and elongation during chromosome replication
F0315_03570	COG0359	binds to the 23S rRNA
F0315_03575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0315_03580	COG2965	DNA replication, synthesis of RNA primer
F0315_03585	COG0360	Binds together with S18 to 16S ribosomal RNA
F0315_03595	COG2906	2 iron, 2 sulfur cluster binding
F0315_03600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0315_03605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0315_03610	COG0049	tRNA binding
F0315_03615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0315_03625	COG2923	Belongs to the DsrF TusC family
F0315_03630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F0315_03635	COG2964	Protein conserved in bacteria
F0315_03640	COG0545	Peptidyl-prolyl cis-trans isomerase
F0315_03650	COG2900	Belongs to the SlyX family
F0315_03655	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
F0315_03660	COG0330	HflC and HflK could
F0315_03665	COG0330	HflC and HflK could
F0315_03670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0315_03675	COG1923	regulation of RNA biosynthetic process
F0315_03680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0315_03685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F0315_03695	COG0802	atpase or kinase
F0315_03700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0315_03750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F0315_03755	COG1162	GTPase activity
F0315_03760	COG0688	phosphatidylethanolamine metabolic process
F0315_03765	COG0471	metal ion transport
F0315_03775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F0315_03780	COG4942	peptidase
F0315_03795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0315_03800	COG2816	NAD+ diphosphatase activity
F0315_03805	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
F0315_03810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0315_03815	COG0085	RNA polymerase activity
F0315_03820	COG0222	ribosome binding
F0315_03825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0315_03830	COG0081	regulation of translation
F0315_03835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F0315_03840	COG0250	Participates in transcription elongation, termination and antitermination
F0315_03845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0315_03850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0315_03875	COG1072	(Pantothenic acid kinase))
F0315_03885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0315_03895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0315_03935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F0315_03945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F0315_03950	COG3118	belongs to the thioredoxin family
F0315_03955	COG0513	Belongs to the DEAD box helicase family
F0315_03960	COG0248	Ppx GppA phosphatase
F0315_03965	COG2205	protein histidine kinase activity
F0315_03965	COG2202	Pas domain
F0315_03970	COG2814	Major facilitator Superfamily
F0315_03990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0315_03995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0315_04000	COG0511	ligase activity, forming carbon-carbon bonds
F0315_04005	COG0439	Biotin carboxylase
F0315_04020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0315_04025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F0315_04030	COG1609	Transcriptional regulator
F0315_04035	COG0129	dihydroxy-acid dehydratase activity
F0315_04040	COG3265	gluconokinase activity
F0315_04045	COG2610	gluconate transmembrane transporter activity
F0315_04050	COG0800	Aldolase
F0315_04055	COG1982	Orn Lys Arg decarboxylase major
F0315_04060	COG0531	amino acid
F0315_04065	COG3710	Transcriptional regulator
F0315_04070	COG0789	Transcriptional regulator
F0315_04080	COG0138	bifunctional purine biosynthesis protein purh
F0315_04085	COG0151	Belongs to the GarS family
F0315_04095	COG0776	regulation of translation
F0315_04100	COG1253	flavin adenine dinucleotide binding
F0315_04105	COG3068	Protein conserved in bacteria
F0315_04115	COG1573	uracil-dna glycosylase
F0315_04120	COG0668	transmembrane transport
F0315_04125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F0315_04135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0315_04145	COG1482	cell wall glycoprotein biosynthetic process
F0315_04170	COG0438	transferase activity, transferring glycosyl groups
F0315_04185	COG1216	Glycosyl transferase, family 2
F0315_04230	COG1596	polysaccharide export
F0315_04250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_04260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0315_04280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0315_04300	COG2226	methyltransferase
F0315_04335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0315_04355	COG0859	PFAM glycosyl transferase family 9
F0315_04365	COG1519	Transferase
F0315_04370	COG0456	acetyltransferase
F0315_04375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0315_04390	COG3642	lipopolysaccharide core region biosynthetic process
F0315_04395	COG0859	PFAM glycosyl transferase family 9
F0315_04400	COG0463	Glycosyl transferase, family 2
F0315_04405	COG0859	PFAM glycosyl transferase family 9
F0315_04410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0315_04415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0315_04425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0315_04430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0315_04445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F0315_04455	COG1309	transcriptional regulator
F0315_04460	COG1560	Kdo2-lipid A biosynthetic process
F0315_04465	COG1560	Kdo2-lipid A biosynthetic process
F0315_04470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0315_04475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F0315_04480	COG1561	YicC-like family, N-terminal region
F0315_04490	COG1263	PTS System
F0315_04490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_04495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0315_04510	COG0514	ATP-dependent DNA helicase (RecQ)
F0315_04515	COG2962	Rard protein
F0315_04520	COG0405	Gamma-glutamyltransferase
F0315_04530	COG1280	lysine exporter protein (LysE YggA)
F0315_04535	COG0210	DNA helicase
F0315_04545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F0315_04550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_04630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_04640	COG0747	negative chemotaxis
F0315_04735	COG4964	Belongs to the GSP D family
F0315_04770	COG1309	transcriptional regulator
F0315_04775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_04780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_04785	COG2960	long-chain fatty acid transporting porin activity
F0315_04790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0315_04795	COG0583	DNA-binding transcription factor activity
F0315_04865	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
F0315_04870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_04875	COG1739	Uncharacterized protein family UPF0029
F0315_04880	COG1024	Enoyl-CoA hydratase
F0315_04880	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0315_04885	COG0183	Belongs to the thiolase family
F0315_04890	COG0583	DNA-binding transcription factor activity
F0315_04895	COG2814	Major facilitator Superfamily
F0315_04905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0315_04910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0315_04915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0315_04920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0315_04925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0315_04930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0315_04940	COG0356	it plays a direct role in the translocation of protons across the membrane
F0315_04945	COG3312	ion transport
F0315_04950	COG1475	DNA binding
F0315_04955	COG1192	Involved in chromosome partitioning
F0315_04960	COG0357	Ribosomal RNA small subunit methyltransferase G
F0315_04965	COG0445	tRNA wobble uridine modification
F0315_04975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0315_04980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0315_04985	COG0706	membrane insertase activity
F0315_04990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F0315_04995	COG0594	ribonuclease P activity
F0315_05000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0315_05005	COG1126	abc transporter atp-binding protein
F0315_05020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0315_05025	COG0592	DNA-directed DNA polymerase activity
F0315_05030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0315_05035	COG0187	DNA topoisomerase II activity
F0315_05050	COG0071	Belongs to the small heat shock protein (HSP20) family
F0315_05055	COG3977	Valine--pyruvate aminotransferase
F0315_05060	COG0751	glycine-tRNA ligase activity
F0315_05065	COG0752	glycyl-tRNA synthetase alpha subunit
F0315_05070	COG2119	membrane
F0315_05080	COG0425	Belongs to the sulfur carrier protein TusA family
F0315_05090	COG0604	alcohol dehydrogenase
F0315_05100	COG0129	dihydroxy-acid dehydratase activity
F0315_05105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0315_05120	COG0606	chelatase, subunit chli
F0315_05125	COG0204	Acyl-transferase
F0315_05130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0315_05135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F0315_05145	COG3084	Protein conserved in bacteria
F0315_05155	COG4326	sporulation control protein
F0315_05160	COG1272	protein, Hemolysin III
F0315_05170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_05175	COG0569	domain protein
F0315_05180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0315_05180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0315_05185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0315_05190	COG0242	peptide deformylase activity
F0315_05195	COG1652	LysM domain
F0315_05200	COG0758	DNA mediated transformation
F0315_05205	COG2922	Belongs to the Smg family
F0315_05210	COG0551	DNA topoisomerase type I activity
F0315_05215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F0315_05220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0315_05225	COG0009	L-threonylcarbamoyladenylate synthase
F0315_05230	COG0408	coproporphyrinogen oxidase activity
F0315_05235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0315_05245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0315_05280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0315_05285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0315_05295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0315_05300	COG2104	thiamine diphosphate biosynthetic process
F0315_05305	COG2022	thiamine diphosphate biosynthetic process
F0315_05310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0315_05315	COG0006	proline dipeptidase activity
F0315_05315	COG0006	proline dipeptidase activity
F0315_05335	COG1522	sequence-specific DNA binding
F0315_05340	COG5002	protein histidine kinase activity
F0315_05340	COG5001	Diguanylate cyclase
F0315_05345	COG0742	ribosomal rna small subunit methyltransferase
F0315_05355	COG0697	spore germination
F0315_05360	COG0589	response to stress
F0315_05365	COG1528	Iron-storage protein
F0315_05375	COG2081	HI0933 family
F0315_05460	COG0840	transmembrane signaling receptor activity
F0315_05470	COG1322	Protein conserved in bacteria
F0315_05475	COG2226	methyltransferase
F0315_05485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0315_05490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0315_05495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0315_05500	COG0805	protein transport
F0315_05510	COG0534	Mate efflux family protein
F0315_05520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0315_05530	COG2937	Belongs to the GPAT DAPAT family
F0315_05535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F0315_05540	COG3161	chorismate lyase activity
F0315_05550	COG1580	Controls the rotational direction of flagella during chemotaxis
F0315_05560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0315_05570	COG0084	hydrolase, TatD family'
F0315_05590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0315_05590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0315_05595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F0315_05610	COG3078	GTPase activator activity
F0315_05620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0315_05625	COG3071	HemY protein
F0315_05630	COG2959	enzyme of heme biosynthesis
F0315_05635	COG1587	Uroporphyrinogen-III synthase
F0315_05640	COG0181	hydroxymethylbilane synthase activity
F0315_05650	COG3072	Adenylate cyclase
F0315_05655	COG1965	Belongs to the frataxin family
F0315_05665	COG0019	diaminopimelate decarboxylase activity
F0315_05670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0315_05680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F0315_05685	COG1011	Hydrolase
F0315_05690	COG2199	diguanylate cyclase activity
F0315_05690	COG3287	FIST C domain
F0315_05690	COG2200	EAL domain
F0315_05705	COG0561	phosphatase activity
F0315_05710	COG2267	carboxylic ester hydrolase activity
F0315_05715	COG1280	lysine exporter protein (LysE YggA)
F0315_05720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F0315_05725	COG0783	Belongs to the Dps family
F0315_05765	COG0742	ribosomal rna small subunit methyltransferase
F0315_05770	COG0552	protein localization to endoplasmic reticulum
F0315_05775	COG2884	Cell division ATP-binding protein ftsE
F0315_05780	COG2177	Part of the ABC transporter FtsEX involved in
F0315_05785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0315_05790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_05835	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_05865	COG1110	DNA topoisomerase II activity
F0315_05950	COG2003	Belongs to the UPF0758 family
F0315_05955	COG0464	growth
F0315_05965	COG3385	transposase activity
F0315_05970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0315_05990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0315_06040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0315_06045	COG5001	Diguanylate cyclase
F0315_06045	COG3300	MHYT domain
F0315_06055	COG3852	Histidine kinase
F0315_06065	COG0174	glutamine synthetase
F0315_06090	COG1490	D-aminoacyl-tRNA deacylase activity
F0315_06095	COG0456	acetyltransferase
F0315_06105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F0315_06110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F0315_06115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F0315_06120	COG3031	protein transport across the cell outer membrane
F0315_06130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0315_06135	COG1459	type II secretion system
F0315_06140	COG2165	general secretion pathway protein
F0315_06145	COG2165	general secretion pathway protein
F0315_06150	COG2165	general secretion pathway protein
F0315_06155	COG4795	General secretion pathway protein
F0315_06160	COG3156	type II secretion system protein K
F0315_06165	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F0315_06170	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F0315_06180	COG1218	3'(2'),5'-bisphosphate nucleotidase
F0315_06185	COG0494	nUDIX hydrolase
F0315_06190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F0315_06190	COG0316	Belongs to the HesB IscA family
F0315_06195	COG1040	competence protein
F0315_06200	COG0596	Alpha beta hydrolase
F0315_06210	COG2183	response to ionizing radiation
F0315_06215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0315_06230	COG1129	ABC transporter
F0315_06235	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0315_06240	COG1472	Belongs to the glycosyl hydrolase 3 family
F0315_06245	COG2199	diguanylate cyclase activity
F0315_06250	COG0745	RESPONSE REGULATOR receiver
F0315_06260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0315_06265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0315_06270	COG1758	RNA polymerase activity
F0315_06275	COG0194	GDP metabolic process
F0315_06280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F0315_06285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0315_06295	COG3263	regulation of cellular component size
F0315_06305	COG4232	protein-disulfide reductase activity
F0315_06315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0315_06320	COG1027	Aspartate ammonia-lyase
F0315_06325	COG3706	GGDEF domain
F0315_06330	COG3030	protein affecting phage T7 exclusion by the F plasmid
F0315_06335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F0315_06340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F0315_06345	COG2205	protein histidine kinase activity
F0315_06350	COG0745	RESPONSE REGULATOR receiver
F0315_06360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0315_06365	COG0205	6-phosphofructokinase activity
F0315_06370	COG1494	fructose-1,6-bisphosphatase
F0315_06380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F0315_06385	COG0527	aspartate kinase activity
F0315_06385	COG0460	homoserine dehydrogenase
F0315_06390	COG0626	cystathionine gamma-synthase activity
F0315_06395	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F0315_06400	COG0281	malic enzyme
F0315_06405	COG0254	rRNA binding
F0315_06410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0315_06415	COG1609	Transcriptional regulator
F0315_06420	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0315_06425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F0315_06430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F0315_06435	COG1575	Belongs to the MenA family. Type 1 subfamily
F0315_06440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0315_06450	COG0149	triose-phosphate isomerase activity
F0315_06475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0315_06480	COG0459	protein refolding
F0315_06490	COG1509	lysine 2,3-aminomutase activity
F0315_06495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0315_06500	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0315_06505	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0315_06510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0315_06515	COG1053	succinate dehydrogenase
F0315_06520	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F0315_06525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0315_06530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F0315_06535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0315_06545	COG1045	serine acetyltransferase
F0315_06555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0315_06560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0315_06565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0315_06570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0315_06575	COG0137	argininosuccinate synthase activity
F0315_06580	COG0165	Argininosuccinate lyase
F0315_06590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_06595	COG0678	peroxiredoxin activity
F0315_06595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0315_06605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0315_06635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0315_06640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0315_06650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F0315_06655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0315_06660	COG0546	phosphoglycolate phosphatase activity
F0315_06665	COG0180	Tryptophanyl-tRNA synthetase
F0315_06680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0315_06685	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0315_06695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0315_06705	COG1012	belongs to the aldehyde dehydrogenase family
F0315_06715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0315_06720	COG3954	Phosphoribulokinase
F0315_06730	COG0429	hydrolase of the alpha beta-hydrolase fold
F0315_06740	COG0488	(ABC) transporter
F0315_06745	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0315_06760	COG1047	Peptidyl-prolyl cis-trans
F0315_06770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0315_06780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
F0315_06785	COG3083	sulfuric ester hydrolase activity
F0315_06790	COG0557	exoribonuclease II activity
F0315_06795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0315_06800	COG0051	transcription antitermination factor activity, RNA binding
F0315_06805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0315_06810	COG0088	Forms part of the polypeptide exit tunnel
F0315_06815	COG0089	rRNA binding
F0315_06825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0315_06830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0315_06835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0315_06840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0315_06845	COG0255	Belongs to the universal ribosomal protein uL29 family
F0315_06855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0315_06860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0315_06865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0315_06870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0315_06875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0315_06880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0315_06885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0315_06890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0315_06895	COG1841	ribosomal large subunit assembly
F0315_06900	COG0200	Binds to the 23S rRNA
F0315_06905	COG0201	protein transport
F0315_06915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0315_06920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0315_06925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0315_06930	COG0202	RNA polymerase activity
F0315_06935	COG0203	ribosomal protein L17
F0315_06945	COG0545	Peptidyl-prolyl cis-trans isomerase
F0315_06950	COG3266	domain, Protein
F0315_06950	COG3061	Opacity-associated protein A
F0315_06955	COG0697	spore germination
F0315_06960	COG2153	protein acetylation
F0315_06965	COG0513	Belongs to the DEAD box helicase family
F0315_06975	COG0737	Belongs to the 5'-nucleotidase family
F0315_06980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0315_06980	COG1648	precorrin-2 dehydrogenase activity
F0315_06985	COG0175	sulfate reduction
F0315_06990	COG2895	sulfate adenylyltransferase (ATP) activity
F0315_06995	COG0529	Catalyzes the synthesis of activated sulfate
F0315_07015	COG1136	(ABC) transporter
F0315_07015	COG0577	efflux transmembrane transporter activity
F0315_07030	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F0315_07035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_07040	COG0729	surface antigen
F0315_07050	COG2105	PFAM AIG2 family protein
F0315_07055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0315_07060	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F0315_07070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0315_07075	COG0163	prenyltransferase activity
F0315_07080	COG4143	(ABC) transporter
F0315_07085	COG1178	ABC-type Fe3 transport system permease component
F0315_07090	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F0315_07095	COG3028	Belongs to the UPF0307 family
F0315_07100	COG0312	modulator of DNA gyrase
F0315_07105	COG2239	Acts as a magnesium transporter
F0315_07110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_07120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_07125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0315_07135	COG1137	ATPase activity
F0315_07140	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F0315_07155	COG0517	IMP dehydrogenase activity
F0315_07155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F0315_07170	COG1127	ABC transporter
F0315_07175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0315_07180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0315_07185	COG2854	intermembrane phospholipid transfer
F0315_07195	COG5007	Belongs to the BolA IbaG family
F0315_07200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0315_07205	COG0204	Acyl-transferase
F0315_07210	COG0251	oxidation-reduction process
F0315_07215	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
F0315_07220	COG0540	Belongs to the ATCase OTCase family
F0315_07225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F0315_07230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F0315_07240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0315_07245	COG0564	pseudouridine synthase activity
F0315_07250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0315_07255	COG4269	membrane
F0315_07265	COG0525	valine-tRNA ligase activity
F0315_07270	COG2927	DNA polymerase III (CHI subunit)
F0315_07275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0315_07280	COG0795	lipopolysaccharide-transporting ATPase activity
F0315_07285	COG0795	lipopolysaccharide-transporting ATPase activity
F0315_07300	COG3437	response regulator, receiver
F0315_07340	COG0066	3-isopropylmalate dehydratase activity
F0315_07345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0315_07350	COG0473	3-isopropylmalate dehydrogenase activity
F0315_07355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0315_07375	COG0583	DNA-binding transcription factor activity
F0315_07380	COG1022	Amp-dependent synthetase and ligase
F0315_07385	COG0028	Belongs to the TPP enzyme family
F0315_07390	COG0440	acetolactate synthase activity
F0315_07395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0315_07400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0315_07405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0315_07415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F0315_07425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0315_07430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0315_07440	COG0354	folic acid binding
F0315_07445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F0315_07455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0315_07465	COG1595	DNA-templated transcription, initiation
F0315_07475	COG3026	antisigma factor binding
F0315_07480	COG3086	response to oxidative stress
F0315_07485	COG0481	GTPase activity
F0315_07490	COG0681	Belongs to the peptidase S26 family
F0315_07495	COG0571	ribonuclease III activity
F0315_07500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0315_07505	COG1381	Involved in DNA repair and RecF pathway recombination
F0315_07510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F0315_07515	COG0736	holo-[acyl-carrier-protein] synthase activity
F0315_07535	COG2205	protein histidine kinase activity
F0315_07535	COG3437	response regulator, receiver
F0315_07535	COG3850	Histidine kinase
F0315_07535	COG4999	Histidine kinase
F0315_07540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0315_07545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0315_07550	COG3956	TIGRFAM MazG family protein
F0315_07555	COG0504	CTP synthase activity
F0315_07560	COG0148	phosphopyruvate hydratase activity
F0315_07565	COG0617	tRNA 3'-terminal CCA addition
F0315_07570	COG3267	Type II secretory pathway component ExeA
F0315_07570	COG3409	Peptidoglycan-binding domain 1 protein
F0315_07580	COG4991	sh3 domain protein
F0315_07585	COG0306	phosphate transporter
F0315_07590	COG1392	Phosphate transport regulator
F0315_07595	COG3025	triphosphatase activity
F0315_07600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0315_07610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0315_07615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0315_07615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0315_07620	COG1538	Outer membrane efflux protein
F0315_07625	COG0494	nUDIX hydrolase
F0315_07630	COG3151	Protein conserved in bacteria
F0315_07640	COG3150	esterase
F0315_07645	COG0187	DNA topoisomerase II activity
F0315_07650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0315_07655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F0315_07660	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F0315_07665	COG0237	dephospho-CoA kinase activity
F0315_07675	COG1459	type II secretion system
F0315_07680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0315_07690	COG0157	Belongs to the NadC ModD family
F0315_07700	COG0716	FMN binding
F0315_07705	COG4974	Belongs to the 'phage' integrase family
F0315_07710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0315_07715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0315_07720	COG0737	Belongs to the 5'-nucleotidase family
F0315_07730	COG2186	Transcriptional regulator
F0315_07735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0315_07740	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0315_07745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_07755	COG0275	rRNA processing
F0315_07760	COG3116	cell division
F0315_07765	COG0768	penicillin binding
F0315_07770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0315_07775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0315_07780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0315_07785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F0315_07790	COG0772	Belongs to the SEDS family
F0315_07795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0315_07800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0315_07805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0315_07810	COG0849	cell division
F0315_07815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0315_07820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F0315_07830	COG0653	protein targeting
F0315_07835	COG0494	nUDIX hydrolase
F0315_07840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0315_07850	COG0505	Belongs to the CarA family
F0315_07855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0315_07875	COG0730	response to heat
F0315_07880	COG0583	DNA-binding transcription factor activity
F0315_07885	COG2860	membrane
F0315_07890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0315_07900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0315_07910	COG0493	'glutamate synthase
F0315_07915	COG0067	glutamate synthase
F0315_07915	COG0070	glutamate synthase
F0315_07915	COG0069	glutamate synthase activity
F0315_07925	COG0070	glutamate synthase
F0315_07925	COG0069	glutamate synthase activity
F0315_07925	COG0067	glutamate synthase
F0315_07930	COG1242	4 iron, 4 sulfur cluster binding
F0315_07935	COG5001	Diguanylate cyclase
F0315_07935	COG4251	negative regulation of phosphorylation
F0315_07935	COG3706	GGDEF domain
F0315_07935	COG2203	Gaf domain
F0315_07940	COG0784	Response regulator, receiver
F0315_07940	COG2198	Histidine kinase
F0315_07940	COG5002	protein histidine kinase activity
F0315_07945	COG0745	RESPONSE REGULATOR receiver
F0315_07955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0315_07975	COG0083	homoserine kinase activity
F0315_07980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F0315_08030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0315_08035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0315_08050	COG1115	amino acid carrier protein
F0315_08075	COG0084	hydrolase, TatD family'
F0315_08080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0315_08090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0315_08095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F0315_08100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F0315_08105	COG0813	purine-nucleoside phosphorylase activity
F0315_08115	COG0560	Phosphoserine phosphatase
F0315_08125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F0315_08130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0315_08135	COG1022	Amp-dependent synthetase and ligase
F0315_08150	COG3250	beta-galactosidase activity
F0315_08155	COG1609	Transcriptional regulator
F0315_08160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_08175	COG0189	ligase activity
F0315_08175	COG0569	domain protein
F0315_08180	COG0456	acetyltransferase
F0315_08190	COG2171	N-acyltransferase activity
F0315_08200	COG3141	response to X-ray
F0315_08215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F0315_08220	COG1074	ATP-dependent DNA helicase activity
F0315_08225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0315_08240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0315_08240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F0315_08250	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F0315_08255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F0315_08260	COG2166	iron-sulfur cluster assembly
F0315_08265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0315_08270	COG0693	protein deglycase activity
F0315_08275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0315_08280	COG3248	Nucleoside-binding outer membrane protein
F0315_08290	COG1595	DNA-templated transcription, initiation
F0315_08300	COG2211	Major facilitator Superfamily
F0315_08310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0315_08320	COG2813	Specifically methylates the guanine in position
F0315_08325	COG0271	Belongs to the BolA IbaG family
F0315_08330	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_08335	COG1805	sodium ion transport
F0315_08340	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_08345	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_08350	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_08355	COG2871	sodium ion transport
F0315_08360	COG1477	protein flavinylation
F0315_08370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0315_08380	COG3706	GGDEF domain
F0315_08385	COG0733	neurotransmitter:sodium symporter activity
F0315_08395	COG0189	ligase activity
F0315_08400	COG0189	ligase activity
F0315_08400	COG4067	protein conserved in archaea
F0315_08405	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_08410	COG2252	PERMEase
F0315_08415	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F0315_08430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0315_08435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0315_08440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0315_08445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0315_08445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0315_08460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0315_08465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0315_08470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F0315_08475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F0315_08485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0315_08490	COG0024	Methionine aminopeptidase
F0315_08495	COG0052	Belongs to the universal ribosomal protein uS2 family
F0315_08500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0315_08505	COG0528	UMP kinase activity
F0315_08510	COG0233	cytoplasmic translational termination
F0315_08515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0315_08520	COG0575	Belongs to the CDS family
F0315_08525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0315_08530	COG0750	zinc metalloprotease
F0315_08540	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
F0315_08545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_08550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0315_08555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_08560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_08565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0315_08570	COG0587	DNA-directed DNA polymerase activity
F0315_08575	COG0825	malonyl-CoA metabolic process
F0315_08580	COG0037	tRNA processing
F0315_08590	COG0347	Belongs to the P(II) protein family
F0315_08600	COG1388	LysM domain
F0315_08600	COG0741	lytic transglycosylase activity
F0315_08605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0315_08610	COG2226	methyltransferase
F0315_08615	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_08620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0315_08630	COG1960	acyl-CoA dehydrogenase activity
F0315_08635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0315_08640	COG0121	glutamine amidotransferase
F0315_08645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0315_08650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0315_08655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0315_08660	COG1187	pseudouridine synthase activity
F0315_08665	COG2840	Smr protein MutS2
F0315_08695	COG2608	mercury ion transmembrane transporter activity
F0315_08695	COG2217	Heavy metal translocating P-type atpase
F0315_08700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0315_08720	COG2375	cellular response to nickel ion
F0315_08760	COG0835	chemotaxis
F0315_08760	COG0784	Response regulator, receiver
F0315_08765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0315_08770	COG1815	bacterial-type flagellum-dependent cell motility
F0315_08775	COG1558	bacterial-type flagellum-dependent cell motility
F0315_08780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F0315_08785	COG1749	Flagellar hook protein flgE
F0315_08790	COG4787	bacterial-type flagellum-dependent cell motility
F0315_08795	COG4786	Flagellar basal body rod
F0315_08800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F0315_08805	COG1706	bacterial-type flagellum-dependent cell motility
F0315_08810	COG3951	Flagellar rod assembly protein muramidase FlgJ
F0315_08810	COG1705	Flagellar rod assembly protein muramidase FlgJ
F0315_08825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_08830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_08915	COG0012	GTP binding
F0315_08920	COG0193	aminoacyl-tRNA hydrolase activity
F0315_08925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0315_08930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F0315_08935	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F0315_08940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0315_08945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0315_08950	COG2890	protein-(glutamine-N5) methyltransferase activity
F0315_08955	COG3094	Invasion gene expression up-regulator, SirB
F0315_08960	COG2912	Transglutaminase-like superfamily
F0315_08965	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F0315_08970	COG0737	Belongs to the 5'-nucleotidase family
F0315_08975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0315_08980	COG2233	PERMEase
F0315_09000	COG1393	Belongs to the ArsC family
F0315_09005	COG4783	chaperone-mediated protein folding
F0315_09025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F0315_09035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0315_09040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
F0315_09050	COG1876	peptidase activity
F0315_09055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0315_09060	COG1393	Belongs to the ArsC family
F0315_09080	COG2837	iron assimilation
F0315_09085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_09090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_09095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_09100	COG1334	flagellar protein FlaG
F0315_09105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F0315_09115	COG1516	flagellar protein fliS
F0315_09120	COG2204	response regulator
F0315_09125	COG4191	Histidine kinase
F0315_09130	COG2204	response regulator
F0315_09135	COG1677	Flagellar hook-basal body complex protein FliE
F0315_09145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F0315_09150	COG1317	bacterial-type flagellum organization
F0315_09175	COG1580	Controls the rotational direction of flagella during chemotaxis
F0315_09200	COG1987	bacterial-type flagellum assembly
F0315_09205	COG1684	flagellar biosynthetic protein fliR
F0315_09220	COG2890	protein-(glutamine-N5) methyltransferase activity
F0315_09225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0315_09230	COG2860	membrane
F0315_09235	COG3101	peptidyl-lysine hydroxylation
F0315_09245	COG0431	NADPH-dependent FMN reductase
F0315_09250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F0315_09250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0315_09255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0315_09260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0315_09265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0315_09270	COG0735	belongs to the Fur family
F0315_09280	COG0583	DNA-binding transcription factor activity
F0315_09290	COG1346	cytolysis
F0315_09305	COG0596	Alpha beta hydrolase
F0315_09310	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
F0315_09315	COG0033	Phosphoglucomutase
F0315_09325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0315_09330	COG0372	Belongs to the citrate synthase family
F0315_09335	COG2009	succinate dehydrogenase
F0315_09340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F0315_09345	COG1053	succinate dehydrogenase
F0315_09355	COG0567	Dehydrogenase, E1 component
F0315_09360	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0315_09365	COG0045	succinate-CoA ligase (ADP-forming) activity
F0315_09375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0315_09380	COG1121	(ABC) transporter
F0315_09385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F0315_09390	COG4977	sequence-specific DNA binding
F0315_09395	COG1918	ferrous iron import across plasma membrane
F0315_09415	COG0018	arginyl-trna synthetase
F0315_09425	COG1025	Belongs to the peptidase M16 family
F0315_09430	COG2062	phosphohistidine phosphatase, SixA
F0315_09445	COG0455	bacterial-type flagellum organization
F0315_09460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F0315_09465	COG2198	Histidine kinase
F0315_09465	COG0643	Histidine kinase
F0315_09470	COG2201	protein-glutamate methylesterase activity
F0315_09475	COG1192	Involved in chromosome partitioning
F0315_09485	COG0835	chemotaxis
F0315_09495	COG4133	protoheme IX ABC transporter activity
F0315_09500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0315_09505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0315_09515	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F0315_09520	COG1138	Cytochrome C-type biogenesis protein
F0315_09525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0315_09540	COG2853	Lipoprotein
F0315_09560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F0315_09590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0315_09620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F0315_09665	COG0123	including yeast histone deacetylase and acetoin utilization protein
F0315_09680	COG3083	sulfuric ester hydrolase activity
F0315_09690	COG3081	Nucleoid-associated protein
F0315_09700	COG1757	Na H antiporter
F0315_09705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0315_09710	COG2095	MarC family integral membrane protein
F0315_09715	COG1012	belongs to the aldehyde dehydrogenase family
F0315_09715	COG1454	alcohol dehydrogenase
F0315_09730	COG0659	secondary active sulfate transmembrane transporter activity
F0315_09735	COG1530	ribonuclease E activity
F0315_09750	COG0564	pseudouridine synthase activity
F0315_09755	COG0424	maF-like protein
F0315_09760	COG1399	metal-binding, possibly nucleic acid-binding protein
F0315_09765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0315_09770	COG0416	fatty acid biosynthetic process
F0315_09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0315_09780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F0315_09785	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_09790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0315_09795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0315_09800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0315_09805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0315_09810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0315_09820	COG0084	hydrolase, TatD family'
F0315_09825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_09825	COG1263	PTS System
F0315_09835	COG0733	neurotransmitter:sodium symporter activity
F0315_09850	COG4667	esterase of the alpha-beta hydrolase superfamily
F0315_09855	COG0469	pyruvate kinase activity
F0315_09860	COG1940	carbohydrate kinase activity
F0315_09865	COG0784	Response regulator, receiver
F0315_09865	COG0835	chemotaxis
F0315_09895	COG2226	methyltransferase
F0315_09905	COG0676	glucose-6-phosphate 1-epimerase activity
F0315_09910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0315_09915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_09930	COG0252	asparaginase activity
F0315_09935	COG0616	signal peptide processing
F0315_09940	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0315_09940	COG1902	pentaerythritol trinitrate reductase activity
F0315_09945	COG0788	formyltetrahydrofolate deformylase activity
F0315_09955	COG1199	ATP-dependent helicase activity
F0315_09960	COG1214	PFAM Peptidase M22, glycoprotease
F0315_09975	COG0596	Alpha beta hydrolase
F0315_09980	COG0318	PFAM AMP-dependent synthetase and ligase
F0315_09985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F0315_10005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F0315_10010	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F0315_10015	COG0436	Aminotransferase
F0315_10020	COG1169	isochorismate synthase
F0315_10025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F0315_10030	COG0596	Alpha beta hydrolase
F0315_10040	COG1441	menaquinone biosynthetic process
F0315_10050	COG3135	benzoate transporter
F0315_10055	COG1396	sequence-specific DNA binding
F0315_10065	COG0477	Major facilitator Superfamily
F0315_10085	COG3015	lipoprotein NlpE involved in copper resistance
F0315_10090	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F0315_10095	COG2894	cell division
F0315_10100	COG0850	regulation of cytokinetic process
F0315_10105	COG3100	YcgL domain-containing protein
F0315_10110	COG2951	lytic endotransglycosylase activity
F0315_10125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0315_10130	COG3325	Belongs to the glycosyl hydrolase 18 family
F0315_10130	COG3469	chitinase activity
F0315_10140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0315_10175	COG3550	peptidyl-serine autophosphorylation
F0315_10205	COG2205	protein histidine kinase activity
F0315_10210	COG0745	RESPONSE REGULATOR receiver
F0315_10215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_10220	COG0569	domain protein
F0315_10225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_10265	COG4264	IucA IucC family
F0315_10275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0315_10280	COG1120	ATPase activity
F0315_10315	COG0671	phosphoesterase, PA-phosphatase related
F0315_10330	COG4589	Belongs to the CDS family
F0315_10340	COG3300	MHYT domain
F0315_10340	COG5001	Diguanylate cyclase
F0315_10355	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F0315_10360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F0315_10365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0315_10370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F0315_10380	COG4191	Histidine kinase
F0315_10390	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0315_10400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0315_10405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0315_10410	COG0776	regulation of translation
F0315_10415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0315_10420	COG1555	photosystem II stabilization
F0315_10425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0315_10430	COG0539	negative regulation of cytoplasmic translation
F0315_10435	COG0776	regulation of translation
F0315_10440	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F0315_10445	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F0315_10450	COG0284	orotidine-5'-phosphate decarboxylase activity
F0315_10455	COG4174	ABC transporter (Permease)
F0315_10460	COG4239	(ABC) transporter, permease
F0315_10465	COG0747	negative chemotaxis
F0315_10470	COG0444	Belongs to the ABC transporter superfamily
F0315_10475	COG4608	Belongs to the ABC transporter superfamily
F0315_10500	COG0583	DNA-binding transcription factor activity
F0315_10510	COG0686	Belongs to the AlaDH PNT family
F0315_10515	COG1522	sequence-specific DNA binding
F0315_10520	COG1674	ftsk spoiiie
F0315_10525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F0315_10530	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0315_10535	COG2186	Transcriptional regulator
F0315_10545	COG0840	transmembrane signaling receptor activity
F0315_10550	COG0537	adenosine 5'-monophosphoramidase activity
F0315_10580	COG1252	NADH dehydrogenase
F0315_10600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0315_10610	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0315_10615	COG1136	(ABC) transporter
F0315_10620	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0315_10630	COG2333	competence protein COMEC
F0315_10630	COG0658	competence protein
F0315_10635	COG1132	(ABC) transporter
F0315_10640	COG1663	tetraacyldisaccharide 4'-kinase activity
F0315_10650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F0315_10675	COG0745	RESPONSE REGULATOR receiver
F0315_10685	COG2719	SpoVR family
F0315_10690	COG2718	Belongs to the UPF0229 family
F0315_10695	COG2766	serine protein kinase
F0315_10700	COG3013	Belongs to the UPF0304 family
F0315_10710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0315_10715	COG0840	transmembrane signaling receptor activity
F0315_10785	COG4215	(ABC) transporter
F0315_10795	COG0708	Exodeoxyribonuclease III
F0315_10800	COG0840	transmembrane signaling receptor activity
F0315_10810	COG3923	Primosomal replication protein n
F0315_10815	COG0730	response to heat
F0315_10820	COG1199	ATP-dependent helicase activity
F0315_10835	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F0315_10840	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_10845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0315_10850	COG0215	cysteine-tRNA ligase activity
F0315_10855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0315_10860	COG0632	four-way junction helicase activity
F0315_10865	COG2255	four-way junction helicase activity
F0315_10870	COG1271	oxidase subunit
F0315_10875	COG1294	oxidase, subunit
F0315_10880	COG4890	Cyd operon protein YbgT
F0315_10885	COG3790	cyd operon protein YbgE
F0315_10890	COG0824	Thioesterase
F0315_10895	COG0811	peptide transport
F0315_10910	COG0823	Involved in the tonB-independent uptake of proteins
F0315_10915	COG2885	chlorophyll binding
F0315_10925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0315_10935	COG0784	Response regulator, receiver
F0315_10935	COG5002	protein histidine kinase activity
F0315_10945	COG1012	belongs to the aldehyde dehydrogenase family
F0315_10950	COG3284	Transcriptional regulator
F0315_10955	COG4628	conserved protein (DUF2132)
F0315_10975	COG1940	carbohydrate kinase activity
F0315_10980	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F0315_10990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F0315_10995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0315_11000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F0315_11005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0315_11010	COG1737	Transcriptional regulator
F0315_11015	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
F0315_11040	COG3069	C4-dicarboxylate transmembrane transporter activity
F0315_11045	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_11055	COG2200	EAL domain
F0315_11060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_11065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_11075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0315_11075	COG3008	intermembrane lipid transfer
F0315_11080	COG2995	paraquat-inducible protein a
F0315_11085	COG0668	transmembrane transport
F0315_11095	COG1309	transcriptional regulator
F0315_11100	COG1012	belongs to the aldehyde dehydrogenase family
F0315_11125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0315_11130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0315_11135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F0315_11140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F0315_11150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0315_11160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0315_11165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0315_11170	COG0297	glycogen (starch) synthase activity
F0315_11195	COG3070	regulator of competence-specific genes
F0315_11200	COG1609	Transcriptional regulator
F0315_11210	COG3381	protein complex oligomerization
F0315_11215	COG0745	RESPONSE REGULATOR receiver
F0315_11220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0315_11225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0315_11230	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
F0315_11235	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F0315_11240	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F0315_11255	COG1032	radical SAM domain protein
F0315_11265	COG0612	Peptidase, M16
F0315_11280	COG0583	DNA-binding transcription factor activity
F0315_11285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0315_11295	COG2350	Protein conserved in bacteria
F0315_11300	COG1607	acyl-coa hydrolase
F0315_11305	COG2917	probably involved in intracellular septation
F0315_11320	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0315_11325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0315_11340	COG2116	formate transmembrane transporter activity
F0315_11350	COG4459	periplasmic nitrate reductase
F0315_11355	COG3005	denitrification pathway
F0315_11360	COG0243	molybdopterin cofactor binding
F0315_11380	COG1227	inorganic diphosphatase activity
F0315_11395	COG4172	Belongs to the ABC transporter superfamily
F0315_11405	COG4171	peptide transport system, permease
F0315_11410	COG4168	peptide transport system, permease
F0315_11420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F0315_11425	COG1842	Phage shock protein A
F0315_11440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_11455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0315_11460	COG2818	Glycosylase
F0315_11465	COG0626	cystathionine gamma-synthase activity
F0315_11475	COG0733	neurotransmitter:sodium symporter activity
F0315_11485	COG0564	pseudouridine synthase activity
F0315_11490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0315_11495	COG4136	ATPase activity
F0315_11500	COG4135	transport system, permease component
F0315_11505	COG4134	Bacterial extracellular solute-binding protein
F0315_11515	COG3313	Fe-S protein
F0315_11525	COG0842	Transport permease protein
F0315_11530	COG1131	(ABC) transporter
F0315_11535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_11540	COG0814	amino acid
F0315_11550	COG2239	Acts as a magnesium transporter
F0315_11570	COG4934	collagen metabolic process
F0315_11605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_11620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0315_11625	COG5002	protein histidine kinase activity
F0315_11640	COG1061	Type III restriction enzyme res subunit
F0315_11645	COG1187	pseudouridine synthase activity
F0315_11650	COG2814	Major facilitator Superfamily
F0315_11660	COG0702	epimerase
F0315_11665	COG0534	Mate efflux family protein
F0315_11670	COG4181	ATPase activity
F0315_11685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0315_11700	COG1748	Saccharopine dehydrogenase
F0315_11705	COG0019	diaminopimelate decarboxylase activity
F0315_11715	COG1538	Outer membrane efflux protein
F0315_11800	COG0583	DNA-binding transcription factor activity
F0315_11810	COG1451	nucleotide metabolic process
F0315_11825	COG3063	Type IV pilus biogenesis stability protein PilW
F0315_11830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F0315_11850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_11865	COG3290	protein histidine kinase activity
F0315_11870	COG4565	transcriptional regulatory protein
F0315_11880	COG0835	chemotaxis
F0315_11880	COG0784	Response regulator, receiver
F0315_11900	COG3706	GGDEF domain
F0315_11900	COG0745	RESPONSE REGULATOR receiver
F0315_11920	COG1085	galactose-1-phosphate uridylyltransferase
F0315_11925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0315_11930	COG2017	converts alpha-aldose to the beta-anomer
F0315_11935	COG3706	GGDEF domain
F0315_11940	COG2199	diguanylate cyclase activity
F0315_11940	COG2200	EAL domain
F0315_11945	COG0753	catalase activity
F0315_12000	COG1271	oxidase subunit
F0315_12005	COG1294	oxidase, subunit
F0315_12030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F0315_12035	COG2723	6-phospho-beta-galactosidase activity
F0315_12040	COG1609	Transcriptional regulator
F0315_12045	COG0251	oxidation-reduction process
F0315_12050	COG2731	YhcH YjgK YiaL family protein
F0315_12055	COG0584	glycerophosphoryl diester phosphodiesterase
F0315_12060	COG1349	DNA-binding transcription factor activity
F0315_12065	COG3842	ATPase activity
F0315_12070	COG0395	ABC-type sugar transport system, permease component
F0315_12075	COG1175	transmembrane transport
F0315_12090	COG0811	peptide transport
F0315_12095	COG0811	peptide transport
F0315_12100	COG0848	biopolymer transport protein
F0315_12105	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0315_12115	COG1793	dna ligase
F0315_12125	COG0534	Mate efflux family protein
F0315_12145	COG0791	NLP P60 protein
F0315_12150	COG0840	transmembrane signaling receptor activity
F0315_12165	COG1940	carbohydrate kinase activity
F0315_12180	COG0746	molybdenum cofactor guanylyltransferase activity
F0315_12185	COG3842	ATPase activity
F0315_12190	COG4662	Binding-protein-dependent transport system inner membrane component
F0315_12200	COG2204	response regulator
F0315_12205	COG3852	Histidine kinase
F0315_12210	COG0488	(ABC) transporter
F0315_12215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F0315_12245	COG0243	molybdopterin cofactor binding
F0315_12245	COG3383	formate dehydrogenase (NAD+) activity
F0315_12250	COG0437	4 iron, 4 sulfur cluster binding
F0315_12265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0315_12275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0315_12290	COG2996	Protein conserved in bacteria
F0315_12295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0315_12295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F0315_12300	COG3008	intermembrane lipid transfer
F0315_12305	COG2995	paraquat-inducible protein a
F0315_12310	COG1132	(ABC) transporter
F0315_12315	COG1956	GAF domain-containing protein
F0315_12320	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F0315_12335	COG0308	aminopeptidase N
F0315_12350	COG0167	dihydroorotate dehydrogenase activity
F0315_12360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0315_12360	COG0116	Belongs to the methyltransferase superfamily
F0315_12385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0315_12390	COG1067	ATP-dependent peptidase activity
F0315_12395	COG3120	sequence-specific DNA binding
F0315_12425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0315_12425	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F0315_12470	COG1073	alpha beta
F0315_12470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F0315_12470	COG3064	Membrane
F0315_12475	COG2994	toxin metabolic process
F0315_12500	COG3437	response regulator, receiver
F0315_12500	COG2205	protein histidine kinase activity
F0315_12500	COG4999	Histidine kinase
F0315_12500	COG3850	Histidine kinase
F0315_12515	COG3278	Belongs to the heme-copper respiratory oxidase family
F0315_12530	COG2010	Cytochrome c
F0315_12540	COG2217	Heavy metal translocating P-type atpase
F0315_12555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0315_12560	COG0589	response to stress
F0315_12565	COG0037	tRNA processing
F0315_12585	COG3842	ATPase activity
F0315_12590	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0315_12595	COG1177	transmembrane transport
F0315_12600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0315_12605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0315_12620	COG1115	amino acid carrier protein
F0315_12625	COG1280	lysine exporter protein (LysE YggA)
F0315_12645	COG3501	Rhs element vgr protein
F0315_12655	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F0315_12660	COG0513	Belongs to the DEAD box helicase family
F0315_12680	COG2076	Multidrug Resistance protein
F0315_12685	COG0477	Major facilitator Superfamily
F0315_12690	COG0583	DNA-binding transcription factor activity
F0315_12700	COG0402	S-adenosylhomocysteine deaminase activity
F0315_12705	COG0095	Lipoate-protein ligase
F0315_12710	COG0443	Heat shock 70 kDa protein
F0315_12720	COG1643	Atp-dependent helicase
F0315_12765	COG0443	Heat shock 70 kDa protein
F0315_12770	COG3706	GGDEF domain
F0315_12800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F0315_12805	COG0602	queuosine metabolic process
F0315_12810	COG0561	phosphatase activity
F0315_12820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_12825	COG4597	amino acid ABC transporter
F0315_12830	COG0765	amino acid transport
F0315_12835	COG1126	abc transporter atp-binding protein
F0315_12840	COG0670	Belongs to the BI1 family
F0315_12845	COG2920	part of a sulfur-relay system
F0315_12850	COG1254	Belongs to the acylphosphatase family
F0315_12855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0315_12860	COG3706	GGDEF domain
F0315_12875	COG3850	Histidine kinase
F0315_12875	COG3437	response regulator, receiver
F0315_12875	COG2205	protein histidine kinase activity
F0315_12875	COG4999	Histidine kinase
F0315_12880	COG3437	response regulator, receiver
F0315_12885	COG0625	glutathione transferase activity
F0315_12895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F0315_12905	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_12935	COG0372	Belongs to the citrate synthase family
F0315_12940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F0315_12945	COG2186	Transcriptional regulator
F0315_12950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0315_12975	COG1129	ABC transporter
F0315_13010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_13010	COG4191	Histidine kinase
F0315_13015	COG0471	metal ion transport
F0315_13025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0315_13045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_13050	COG3283	Transcriptional regulator of aromatic amino acids metabolism
F0315_13055	COG3768	UPF0283 membrane protein
F0315_13060	COG3106	COG3106 Predicted ATPase
F0315_13075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0315_13080	COG0494	nUDIX hydrolase
F0315_13085	COG0814	amino acid
F0315_13090	COG1760	l-serine dehydratase
F0315_13095	COG0720	synthase
F0315_13105	COG0017	Asparaginyl-tRNA synthetase
F0315_13110	COG0351	phosphomethylpyrimidine kinase
F0315_13110	COG0352	thiamine-phosphate diphosphorylase activity
F0315_13115	COG2770	Histidine kinase
F0315_13115	COG3437	response regulator, receiver
F0315_13125	COG1448	Aminotransferase
F0315_13140	COG0840	transmembrane signaling receptor activity
F0315_13145	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F0315_13150	COG2943	transferase activity, transferring hexosyl groups
F0315_13160	COG3394	polysaccharide catabolic process
F0315_13165	COG1486	melibiose metabolic process
F0315_13170	COG1447	Phosphotransferase system cellobiose-specific component IIA
F0315_13180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0315_13185	COG0726	polysaccharide deacetylase
F0315_13190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0315_13195	COG1846	Transcriptional regulator
F0315_13225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F0315_13240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0315_13245	COG3108	Peptidase M15
F0315_13275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0315_13285	COG2814	Major facilitator Superfamily
F0315_13300	COG1278	Cold shock
F0315_13310	COG3088	subunit of a heme lyase
F0315_13310	COG4235	cytochrome complex assembly
F0315_13320	COG1138	Cytochrome C-type biogenesis protein
F0315_13325	COG3301	Polysulphide reductase, NrfD
F0315_13330	COG0437	4 iron, 4 sulfur cluster binding
F0315_13355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0315_13360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0315_13365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0315_13415	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
F0315_13420	COG4139	cobalamin transport
F0315_13425	COG2988	succinylglutamate desuccinylase activity
F0315_13440	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F0315_13445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0315_13450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_13460	COG2925	Exonuclease
F0315_13470	COG1346	cytolysis
F0315_13475	COG0295	cytidine deaminase activity
F0315_13495	COG0500	methyltransferase
F0315_13515	COG0776	regulation of translation
F0315_13520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_13520	COG0072	phenylalanine-tRNA ligase activity
F0315_13525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0315_13530	COG0456	acetyltransferase
F0315_13565	COG0322	excinuclease ABC activity
F0315_13570	COG2197	response regulator
F0315_13575	COG0417	DNA replication proofreading
F0315_13580	COG5001	Diguanylate cyclase
F0315_13590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0315_13610	COG1228	amidohydrolase
F0315_13615	COG0010	Belongs to the arginase family
F0315_13620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0315_13625	COG2986	histidine ammonia-lyase
F0315_13645	COG0247	lactate metabolic process
F0315_13645	COG0277	FAD linked oxidase domain protein
F0315_13665	COG2885	chlorophyll binding
F0315_13685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0315_13695	COG0281	malic enzyme
F0315_13705	COG2949	membrane
F0315_13710	COG3706	GGDEF domain
F0315_13710	COG0745	RESPONSE REGULATOR receiver
F0315_13715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0315_13725	COG0492	ferredoxin-NADP+ reductase activity
F0315_13730	COG4988	ABC transporter
F0315_13735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F0315_13740	COG1187	pseudouridine synthase activity
F0315_13745	COG0009	L-threonylcarbamoyladenylate synthase
F0315_13750	COG0613	PHP domain protein
F0315_13760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0315_13765	COG0512	Glutamine amidotransferase of anthranilate synthase
F0315_13770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0315_13775	COG0135	phosphoribosylanthranilate isomerase activity
F0315_13775	COG0134	indole-3-glycerol-phosphate synthase activity
F0315_13780	COG0133	tryptophan synthase activity
F0315_13785	COG0159	tryptophan synthase activity
F0315_13795	COG1435	thymidine kinase activity
F0315_13800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0315_13805	COG1801	Protein of unknown function DUF72
F0315_13810	COG4106	trans-aconitate 2-methyltransferase activity
F0315_13815	COG0500	methyltransferase
F0315_13820	COG0189	ligase activity
F0315_13820	COG4067	protein conserved in archaea
F0315_13835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0315_13845	COG3852	Histidine kinase
F0315_13860	COG3070	regulator of competence-specific genes
F0315_13870	COG2431	L-lysine efflux transmembrane transporter activity
F0315_13880	COG0076	glutamate decarboxylase activity
F0315_13885	COG1737	Transcriptional regulator
F0315_13890	COG1012	belongs to the aldehyde dehydrogenase family
F0315_13890	COG1454	alcohol dehydrogenase
F0315_13895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0315_13905	COG0542	response to heat
F0315_13910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0315_13915	COG1278	Cold shock
F0315_13925	COG1187	pseudouridine synthase activity
F0315_13930	COG0140	phosphoribosyl-ATP diphosphatase activity
F0315_13930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0315_13935	COG0107	imidazoleglycerol-phosphate synthase activity
F0315_13940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0315_13945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0315_13950	COG0131	Imidazoleglycerol-phosphate dehydratase
F0315_13950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0315_13955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0315_13960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0315_13965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0315_13970	COG1757	Na H antiporter
F0315_13975	COG2916	Histone family protein nucleoid-structuring protein H-NS
F0315_13980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_13985	COG0482	sulfurtransferase activity
F0315_13990	COG2915	High frequency lysogenization protein hflD homolog
F0315_13995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0315_14005	COG2268	Band 7 protein
F0315_14015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0315_14030	COG0300	oxidoreductase activity
F0315_14040	COG0501	Belongs to the peptidase M48B family
F0315_14050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0315_14055	COG2226	methyltransferase
F0315_14060	COG0156	8-amino-7-oxononanoate synthase activity
F0315_14065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0315_14070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F0315_14075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0315_14080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0315_14085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F0315_14090	COG0653	protein targeting
F0315_14095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0315_14100	COG3706	GGDEF domain
F0315_14110	COG4120	Belongs to the binding-protein-dependent transport system permease family
F0315_14120	COG4628	conserved protein (DUF2132)
F0315_14125	COG3092	negative regulation of chromosome organization
F0315_14130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0315_14135	COG0857	belongs to the CobB CobQ family
F0315_14135	COG0280	phosphate acetyltransferase
F0315_14140	COG0435	Glutathione S-transferase
F0315_14145	COG4608	Belongs to the ABC transporter superfamily
F0315_14150	COG0444	Belongs to the ABC transporter superfamily
F0315_14155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_14160	COG0601	transmembrane transport
F0315_14175	COG4191	Histidine kinase
F0315_14180	COG2204	response regulator
F0315_14185	COG3300	MHYT domain
F0315_14185	COG5001	Diguanylate cyclase
F0315_14190	COG4191	Histidine kinase
F0315_14195	COG5002	protein histidine kinase activity
F0315_14205	COG2201	protein-glutamate methylesterase activity
F0315_14220	COG0009	L-threonylcarbamoyladenylate synthase
F0315_14255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_14260	COG3716	PTS system mannose fructose sorbose family IID component
F0315_14270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_14275	COG2222	sugar isomerase
F0315_14285	COG1349	DNA-binding transcription factor activity
F0315_14290	COG1349	DNA-binding transcription factor activity
F0315_14305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0315_14310	COG0640	Transcriptional regulator
F0315_14320	COG3706	GGDEF domain
F0315_14340	COG1946	Acyl-CoA thioesterase
F0315_14345	COG1522	sequence-specific DNA binding
F0315_14355	COG0616	signal peptide processing
F0315_14360	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_14375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0315_14380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0315_14385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0315_14390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0315_14395	COG2832	Protein of unknown function (DUF454)
F0315_14405	COG0745	RESPONSE REGULATOR receiver
F0315_14410	COG0583	DNA-binding transcription factor activity
F0315_14415	COG0778	Nitroreductase
F0315_14420	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0315_14420	COG1024	Enoyl-CoA hydratase
F0315_14425	COG0183	Belongs to the thiolase family
F0315_14440	COG2067	long-chain fatty acid transport protein
F0315_14450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0315_14455	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F0315_14460	COG2982	Protein involved in outer membrane biogenesis
F0315_14465	COG0572	uridine kinase
F0315_14480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_14480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_14495	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F0315_14510	COG4109	DRTGG domain
F0315_14515	COG2199	diguanylate cyclase activity
F0315_14520	COG0314	molybdopterin synthase activity
F0315_14525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F0315_14530	COG0315	cyclic pyranopterin monophosphate synthase activity
F0315_14535	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0315_14540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0315_14545	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0315_14550	COG2198	Histidine kinase
F0315_14555	COG2204	response regulator
F0315_14565	COG0556	nucleotide-excision repair
F0315_14575	COG0582	viral genome integration into host DNA
F0315_14600	COG2003	Belongs to the UPF0758 family
F0315_14650	COG2831	hemolysin activation secretion protein
F0315_14740	COG0494	nUDIX hydrolase
F0315_14775	COG0456	acetyltransferase
F0315_15120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_15160	COG0625	glutathione transferase activity
F0315_15175	COG0454	-acetyltransferase
F0315_15195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F0315_15460	COG0384	phenazine biosynthesis protein PhzF
F0315_15510	COG0456	acetyltransferase
F0315_15525	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_15580	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F0315_15610	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F0315_15625	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0315_15630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F0315_15670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0315_15675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0315_15685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0315_15690	COG0583	DNA-binding transcription factor activity
F0315_15700	COG0697	spore germination
F0315_15715	COG1943	Transposase
F0315_15730	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0315_15740	COG4804	nuclease activity
F0315_15770	COG2916	Histone family protein nucleoid-structuring protein H-NS
F0315_15830	COG1518	maintenance of DNA repeat elements
F0315_15880	COG3550	peptidyl-serine autophosphorylation
F0315_15900	COG0640	Transcriptional regulator
F0315_15910	COG2391	methyltransferase activity
F0315_15930	COG0778	Nitroreductase
F0315_15935	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0315_15940	COG0583	DNA-binding transcription factor activity
F0315_15960	COG1335	isochorismatase
F0315_15975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0315_16000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0315_16005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0315_16015	COG2390	Transcriptional regulator
F0315_16025	COG2897	thiosulfate sulfurtransferase activity
F0315_16035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0315_16045	COG0302	gtp cyclohydrolase
F0315_16050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_16050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_16055	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F0315_16060	COG1970	mechanosensitive ion channel activity
F0315_16065	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F0315_16075	COG1011	Hydrolase
F0315_16080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0315_16085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0315_16095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0315_16105	COG3842	ATPase activity
F0315_16150	COG4166	transmembrane transport
F0315_16155	COG4174	ABC transporter (Permease)
F0315_16160	COG4239	(ABC) transporter, permease
F0315_16165	COG4172	Belongs to the ABC transporter superfamily
F0315_16185	COG0625	glutathione transferase activity
F0315_16210	COG2050	protein possibly involved in aromatic compounds catabolism
F0315_16230	COG0583	DNA-binding transcription factor activity
F0315_16235	COG0045	succinate-CoA ligase (ADP-forming) activity
F0315_16235	COG1042	CoA-binding domain protein
F0315_16235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_16245	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0315_16255	COG0023	Translation Initiation Factor
F0315_16275	COG0745	RESPONSE REGULATOR receiver
F0315_16285	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F0315_16290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F0315_16305	COG3706	GGDEF domain
F0315_16325	COG3706	GGDEF domain
F0315_16365	COG2824	Alkylphosphonate utilization operon protein PhnA
F0315_16375	COG0861	Integral membrane protein TerC family
F0315_16380	COG0737	Belongs to the 5'-nucleotidase family
F0315_16385	COG3593	DNA synthesis involved in DNA repair
F0315_16395	COG0583	DNA-binding transcription factor activity
F0315_16400	COG2116	formate transmembrane transporter activity
F0315_16410	COG3038	cytochrome b561
F0315_16420	COG2200	EAL domain
F0315_16435	COG0523	cobalamin synthesis protein
F0315_16440	COG0038	chloride channel
F0315_16450	COG0156	8-amino-7-oxononanoate synthase activity
F0315_16455	COG0784	Response regulator, receiver
F0315_16455	COG2205	protein histidine kinase activity
F0315_16460	COG0419	ATPase involved in DNA repair
F0315_16465	COG0420	3'-5' exonuclease activity
F0315_16470	COG1609	Transcriptional regulator
F0315_16475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_16475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_16480	COG1105	Belongs to the carbohydrate kinase PfkB family
F0315_16485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F0315_16485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0315_16485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0315_16490	COG4067	protein conserved in archaea
F0315_16490	COG0189	ligase activity
F0315_16500	COG0602	queuosine metabolic process
F0315_16505	COG1328	CTP reductase activity
F0315_16540	COG2181	nitrate reductase activity
F0315_16545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F0315_16550	COG1140	nitrate reductase beta subunit
F0315_16555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F0315_16560	COG2223	nitrite transmembrane transporter activity
F0315_16570	COG2197	response regulator
F0315_16630	COG1263	PTS System
F0315_16630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_16640	COG1621	beta-fructofuranosidase activity
F0315_16645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_16650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0315_16660	COG0545	Peptidyl-prolyl cis-trans isomerase
F0315_16665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0315_16670	COG0840	transmembrane signaling receptor activity
F0315_16675	COG3069	C4-dicarboxylate transmembrane transporter activity
F0315_16680	COG1760	l-serine dehydratase
F0315_16700	COG1609	Transcriptional regulator
F0315_16705	COG2197	response regulator
F0315_16710	COG3850	Histidine kinase
F0315_16715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0315_16750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0315_16755	COG2197	response regulator
F0315_16760	COG3851	Histidine kinase
F0315_16765	COG2271	Major facilitator Superfamily
F0315_16770	COG1840	ABC-type Fe3 transport system, periplasmic component
F0315_16780	COG3842	ATPase activity
F0315_16785	COG3243	poly(R)-hydroxyalkanoic acid synthase
F0315_16795	COG0183	Belongs to the thiolase family
F0315_16805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_16810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_16825	COG3706	GGDEF domain
F0315_16830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0315_16840	COG1979	alcohol dehydrogenase
F0315_16855	COG4191	Histidine kinase
F0315_16860	COG1840	ABC-type Fe3 transport system, periplasmic component
F0315_16865	COG2271	Major facilitator Superfamily
F0315_16870	COG0469	pyruvate kinase activity
F0315_16875	COG0784	Response regulator, receiver
F0315_16875	COG2205	protein histidine kinase activity
F0315_16875	COG2198	Histidine kinase
F0315_16880	COG1879	ABC-type sugar transport system periplasmic component
F0315_16885	COG1803	Methylglyoxal synthase
F0315_16890	COG1335	isochorismatase
F0315_16900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F0315_16915	COG0210	DNA helicase
F0315_16920	COG1289	transmembrane transporter activity
F0315_16950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F0315_16955	COG4149	molybdate abc transporter
F0315_16960	COG0725	ABC transporter, periplasmic molybdate-binding protein
F0315_16965	COG1492	cobalamin metabolic process
F0315_16990	COG0784	Response regulator, receiver
F0315_16990	COG5002	protein histidine kinase activity
F0315_16995	COG1879	ABC-type sugar transport system periplasmic component
F0315_17005	COG2827	Endonuclease containing a URI domain
F0315_17010	COG3132	Protein of unknown function, DUF480
F0315_17035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0315_17040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0315_17045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0315_17050	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
F0315_17055	COG0247	lactate metabolic process
F0315_17060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0315_17065	COG3118	belongs to the thioredoxin family
F0315_17095	COG4160	amino acid transport
F0315_17100	COG4215	(ABC) transporter
F0315_17105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_17110	COG1126	abc transporter atp-binding protein
F0315_17120	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0315_17130	COG0494	nUDIX hydrolase
F0315_17135	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F0315_17145	COG1309	transcriptional regulator
F0315_17150	COG0513	Belongs to the DEAD box helicase family
F0315_17160	COG0814	amino acid
F0315_17165	COG0840	transmembrane signaling receptor activity
F0315_17170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0315_17175	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F0315_17180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F0315_17185	COG1984	allophanate hydrolase subunit 2
F0315_17200	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F0315_17205	COG4181	ATPase activity
F0315_17215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0315_17220	COG1716	ATPase activity
F0315_17220	COG5001	Diguanylate cyclase
F0315_17230	COG0484	heat shock protein binding
F0315_17250	COG0546	phosphoglycolate phosphatase activity
F0315_17265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_17270	COG1368	sulfuric ester hydrolase activity
F0315_17280	COG0513	Belongs to the DEAD box helicase family
F0315_17285	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
F0315_17295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0315_17305	COG3046	protein related to deoxyribodipyrimidine photolyase
F0315_17310	COG3397	chitin binding
F0315_17320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0315_17345	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_17360	COG5002	protein histidine kinase activity
F0315_17365	COG0745	RESPONSE REGULATOR receiver
F0315_17405	COG0561	phosphatase activity
F0315_17410	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F0315_17415	COG3623	hexulose-6-phosphate isomerase
F0315_17430	COG2149	membrane
F0315_17440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_17440	COG1263	PTS System
F0315_17445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0315_17460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0315_17480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0315_17505	COG4604	ABC transporter, ATP-binding protein
F0315_17510	COG4605	iron ion homeostasis
F0315_17515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0315_17535	COG4412	M6 family metalloprotease domain protein
F0315_17535	COG3291	Pkd domain containing protein
F0315_17540	COG0840	transmembrane signaling receptor activity
F0315_17550	COG3240	lipase activity
F0315_17560	COG2814	Major facilitator Superfamily
F0315_17565	COG1757	Na H antiporter
F0315_17575	COG4191	Histidine kinase
F0315_17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_17580	COG0784	Response regulator, receiver
F0315_17580	COG3437	response regulator, receiver
F0315_17585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0315_17590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0315_17595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0315_17600	COG0513	Belongs to the DEAD box helicase family
F0315_17605	COG0516	GMP reductase activity
F0315_17625	COG0814	amino acid
F0315_17630	COG0488	(ABC) transporter
F0315_17635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0315_17635	COG1017	nitric oxide dioxygenase activity
F0315_17640	COG0242	peptide deformylase activity
F0315_17650	COG0579	oxidoreductase
F0315_17685	COG2271	Major facilitator Superfamily
F0315_17690	COG0584	glycerophosphoryl diester phosphodiesterase
F0315_17700	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F0315_17710	COG1609	Transcriptional regulator
F0315_17715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_17720	COG1879	ABC-type sugar transport system periplasmic component
F0315_17725	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0315_17730	COG1129	ABC transporter
F0315_17735	COG1869	D-ribose catabolic process
F0315_17755	COG3501	Rhs element vgr protein
F0315_17850	COG0564	pseudouridine synthase activity
F0315_17860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0315_17865	COG2200	EAL domain
F0315_17865	COG2771	luxR family
F0315_17875	COG0673	inositol 2-dehydrogenase activity
F0315_17880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F0315_17915	COG1342	Belongs to the UPF0251 family
F0315_17930	COG1301	dicarboxylic acid transport
F0315_17935	COG0700	Nucleoside recognition
F0315_17940	COG3366	ferrous iron transmembrane transporter activity
F0315_17945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F0315_17955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0315_17960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F0315_17965	COG2259	Doxx family
F0315_17990	COG0363	glucosamine-6-phosphate deaminase activity
F0315_18005	COG4580	involved in the transport of maltose and maltodextrins
F0315_18020	COG0840	transmembrane signaling receptor activity
F0315_18030	COG0840	transmembrane signaling receptor activity
F0315_18045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0315_18055	COG0513	Belongs to the DEAD box helicase family
F0315_18070	COG2186	Transcriptional regulator
F0315_18080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0315_18090	COG0246	Mannitol dehydrogenase
F0315_18095	COG1904	glucuronate isomerase
F0315_18100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_18105	COG0800	Aldolase
F0315_18120	COG1132	(ABC) transporter
F0315_18130	COG1902	pentaerythritol trinitrate reductase activity
F0315_18140	COG1280	lysine exporter protein (LysE YggA)
F0315_18145	COG2207	Transcriptional regulator
F0315_18165	COG1846	Transcriptional regulator
F0315_18170	COG1764	response to oxidative stress
F0315_18175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0315_18180	COG0697	spore germination
F0315_18200	COG2814	Major facilitator Superfamily
F0315_18205	COG0583	DNA-binding transcription factor activity
F0315_18210	COG4251	negative regulation of phosphorylation
F0315_18210	COG5001	Diguanylate cyclase
F0315_18210	COG2203	Gaf domain
F0315_18210	COG3706	GGDEF domain
F0315_18215	COG0739	heme binding
F0315_18230	COG0659	secondary active sulfate transmembrane transporter activity
F0315_18255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0315_18260	COG0581	inorganic phosphate transmembrane transporter activity
F0315_18265	COG0573	inorganic phosphate transmembrane transporter activity
F0315_18270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0315_18300	COG1770	oligopeptidase
F0315_18305	COG0513	Belongs to the DEAD box helicase family
F0315_18315	COG1388	LysM domain
F0315_18315	COG1376	ErfK ybiS ycfS ynhG family protein
F0315_18320	COG0415	Belongs to the DNA photolyase family
F0315_18330	COG3272	Protein of unknown function (DUF1722)
F0315_18335	COG0813	purine-nucleoside phosphorylase activity
F0315_18350	COG3706	GGDEF domain
F0315_18370	COG0786	glutamate:sodium symporter activity
F0315_18390	COG1999	signal sequence binding
F0315_18400	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F0315_18405	COG0671	phosphoesterase, PA-phosphatase related
F0315_18445	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
F0315_18450	COG0471	metal ion transport
F0315_18485	COG3501	Rhs element vgr protein
F0315_18495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0315_18500	COG1640	4-alpha-glucanotransferase
F0315_18505	COG0058	SHG alpha-glucan phosphorylase activity
F0315_18510	COG2909	trisaccharide binding
F0315_18525	COG2084	Dehydrogenase
F0315_18530	COG0217	transcriptional regulatory protein
F0315_18545	COG0444	Belongs to the ABC transporter superfamily
F0315_18550	COG4608	Belongs to the ABC transporter superfamily
F0315_18580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0315_18585	COG1444	tRNA N-acetyltransferase activity
F0315_18615	COG0745	RESPONSE REGULATOR receiver
F0315_18620	COG0642	Histidine kinase
F0315_18625	COG2194	sulfuric ester hydrolase activity
F0315_18635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_18640	COG0601	transmembrane transport
F0315_18665	COG0835	chemotaxis
F0315_18670	COG0835	chemotaxis
F0315_18675	COG0840	transmembrane signaling receptor activity
F0315_18680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0315_18685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F0315_18705	COG0745	RESPONSE REGULATOR receiver
F0315_18710	COG0434	BtpA family
F0315_18715	COG1879	ABC-type sugar transport system periplasmic component
F0315_18720	COG1129	ABC transporter
F0315_18725	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0315_18740	COG1070	Carbohydrate kinase
F0315_18745	COG1349	DNA-binding transcription factor activity
F0315_18760	COG2274	protein secretion by the type I secretion system
F0315_18780	COG0259	pyridoxamine-phosphate oxidase activity
F0315_18790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0315_18815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0315_18845	COG2409	Drug exporters of the RND superfamily
F0315_18850	COG2197	response regulator
F0315_18860	COG1982	Orn Lys Arg decarboxylase major
F0315_18865	COG0531	amino acid
F0315_18875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0315_18885	COG1901	pseudouridine methyltransferase
F0315_18895	COG4221	oxidoreductase activity
F0315_18910	COG2910	NAD(P)H-binding
F0315_18930	COG0655	NAD(P)H dehydrogenase (quinone) activity
F0315_18935	COG0583	DNA-binding transcription factor activity
F0315_18950	COG0697	spore germination
F0315_18975	COG0673	inositol 2-dehydrogenase activity
F0315_18980	COG3722	fumarate hydratase activity
F0315_18985	COG0246	Mannitol dehydrogenase
F0315_18990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_18990	COG2213	PTS system mannitol-specific
F0315_18995	COG3385	transposase activity
F0315_19000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0315_19005	COG4597	amino acid ABC transporter
F0315_19010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_19020	COG1126	abc transporter atp-binding protein
F0315_19025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0315_19035	COG0840	transmembrane signaling receptor activity
F0315_19045	COG1304	FMN binding
F0315_19050	COG1620	l-lactate permease
F0315_19055	COG0583	DNA-binding transcription factor activity
F0315_19060	COG4172	Belongs to the ABC transporter superfamily
F0315_19070	COG1067	ATP-dependent peptidase activity
F0315_19085	COG2211	Major facilitator Superfamily
F0315_19095	COG3123	guanosine phosphorylase activity
F0315_19100	COG1741	Belongs to the pirin family
F0315_19115	COG0583	DNA-binding transcription factor activity
F0315_19150	COG3706	GGDEF domain
F0315_19155	COG1846	Transcriptional regulator
F0315_19160	COG0784	Response regulator, receiver
F0315_19160	COG0835	chemotaxis
F0315_19165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0315_19170	COG2197	response regulator
F0315_19175	COG0393	Putative heavy-metal-binding
F0315_19190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_19195	COG3842	ATPase activity
F0315_19205	COG1175	transmembrane transport
F0315_19210	COG3833	ABC-type maltose transport systems, permease component
F0315_19225	COG1349	DNA-binding transcription factor activity
F0315_19230	COG3706	GGDEF domain
F0315_19255	COG1278	Cold shock
F0315_19260	COG2354	Protein conserved in bacteria
F0315_19265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0315_19270	COG0418	dihydroorotase activity
F0315_19275	COG3217	Mosc domain protein beta barrel domain protein
F0315_19275	COG0633	Ferredoxin
F0315_19275	COG3217	Mosc domain protein beta barrel domain protein
F0315_19275	COG0633	Ferredoxin
F0315_19310	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0315_19315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0315_19320	COG4558	Periplasmic binding protein
F0315_19325	COG0848	biopolymer transport protein
F0315_19330	COG0811	peptide transport
F0315_19335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0315_19345	COG3721	Heme iron utilization protein
F0315_19350	COG0748	coenzyme F420 binding
F0315_19360	COG1858	cytochrome C peroxidase
F0315_19365	COG3835	regulator
F0315_19370	COG2610	gluconate transmembrane transporter activity
F0315_19375	COG1929	Belongs to the glycerate kinase type-1 family
F0315_19400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0315_19405	COG0363	glucosamine-6-phosphate deaminase activity
F0315_19410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F0315_19415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0315_19435	COG0346	lactoylglutathione lyase activity
F0315_19445	COG2873	o-acetylhomoserine
F0315_19455	COG1063	alcohol dehydrogenase
F0315_19475	COG0582	viral genome integration into host DNA
F0315_19505	COG4626	Terminase
F0315_19505	COG1802	Transcriptional regulator
F0315_19650	COG3833	ABC-type maltose transport systems, permease component
F0315_19655	COG3842	ATPase activity
F0315_19660	COG0584	glycerophosphoryl diester phosphodiesterase
F0315_19710	COG1063	alcohol dehydrogenase
F0315_19720	COG1278	Cold shock
F0315_19725	COG0557	exoribonuclease II activity
F0315_19730	COG1686	Belongs to the peptidase S11 family
F0315_19740	COG3047	cAMP biosynthetic process
F0315_19750	COG3033	Beta-eliminating lyase
F0315_19760	COG3530	Putative quorum-sensing-regulated virulence factor
F0315_19770	COG5002	protein histidine kinase activity
F0315_19770	COG5001	Diguanylate cyclase
F0315_19775	COG1278	Cold shock
F0315_19795	COG2304	oxidoreductase activity
F0315_19815	COG0714	Associated with various cellular activities
F0315_19820	COG0840	transmembrane signaling receptor activity
F0315_19835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0315_19840	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_19850	COG3604	Transcriptional regulator
F0315_19855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0315_19855	COG1017	nitric oxide dioxygenase activity
F0315_19860	COG1278	Cold shock
F0315_19865	COG3036	rescue of stalled ribosome
F0315_19890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F0315_19890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0315_19895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0315_19905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0315_19915	COG3227	Zinc metalloprotease (Elastase)
F0315_19920	COG0366	Alpha amylase catalytic
F0315_19925	COG4989	oxidoreductase activity
F0315_19935	COG1136	(ABC) transporter
F0315_19940	COG0577	efflux transmembrane transporter activity
F0315_19940	COG1136	(ABC) transporter
F0315_19955	COG3275	phosphorelay sensor kinase activity
F0315_19960	COG3279	Response regulator of the LytR AlgR family
F0315_19970	COG3706	GGDEF domain
F0315_19975	COG0531	amino acid
F0315_20000	COG1765	OsmC-like protein
F0315_20005	COG1253	flavin adenine dinucleotide binding
F0315_20010	COG2171	N-acyltransferase activity
F0315_20025	COG2264	protein methyltransferase activity
F0315_20040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0315_20045	COG3186	Phenylalanine-4-hydroxylase
F0315_20050	COG2154	pterin-4-alpha-carbinolamine dehydratase
F0315_20060	COG0534	Mate efflux family protein
F0315_20070	COG2239	Acts as a magnesium transporter
F0315_20080	COG1166	arginine decarboxylase activity
F0315_20100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_20105	COG0800	Aldolase
F0315_20110	COG1085	galactose-1-phosphate uridylyltransferase
F0315_20115	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_20140	COG3119	arylsulfatase activity
F0315_20145	COG3119	arylsulfatase activity
F0315_20150	COG0641	radical SAM
F0315_20165	COG0601	transmembrane transport
F0315_20170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_20180	COG1414	Transcriptional regulator
F0315_20195	COG1686	Belongs to the peptidase S11 family
F0315_20210	COG3338	carbonate dehydratase activity
F0315_20215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0315_20215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0315_20220	COG0509	glycine decarboxylation via glycine cleavage system
F0315_20225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0315_20235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0315_20240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0315_20250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0315_20255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0315_20270	COG0454	-acetyltransferase
F0315_20315	COG0456	acetyltransferase
F0315_20420	COG0494	nUDIX hydrolase
F0315_20465	COG0456	acetyltransferase