locus-tag	class	description
HPY11_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPY11_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY11_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPY11_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY11_00030	ENOG4108ZNX	Heat shock protein
HPY11_00035	ENOG4105JKW	Valine--pyruvate aminotransferase
HPY11_00040	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HPY11_00045	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HPY11_00060	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HPY11_00070	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HPY11_00075	ENOG4105C7B	Threonine dehydratase
HPY11_00080	ENOG4105C01	Dihydroxy-acid dehydratase
HPY11_00085	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPY11_00100	ENOG4105C0P	Mg chelatase subunit ChlI
HPY11_00105	ENOG4106HNH	Acyl-transferase
HPY11_00110	ENOG4108Z33	Thiol disulfide Interchange Protein
HPY11_00115	ENOG4105E27	serine threonine protein kinase
HPY11_00125	ENOG4105PC1	Conserved Protein
HPY11_00130	ENOG4108N23	SpoOM-related protein
HPY11_00135	ENOG4108UT2	hemolysin iii
HPY11_00145	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY11_00150	ENOG4105C1A	potassium transporter peripheral membrane
HPY11_00155	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HPY11_00160	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HPY11_00170	ENOG4108WZM	domain protein
HPY11_00175	ENOG4105C79	DNA protecting protein DprA
HPY11_00180	ENOG4108RPN	Protein smg homolog
HPY11_00185	ENOG4108WI1	Dna topoisomerase
HPY11_00190	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HPY11_00195	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HPY11_00200	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY11_00205	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HPY11_00210	ENOG4105E2X	shikimate dehydrogenase
HPY11_00220	ENOG4108Z0R	Transferase
HPY11_00260	ENOG4105WMR	Protein CrcB homolog
HPY11_00265	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HPY11_00275	ENOG4105D06	uba thif-type nad fad binding protein
HPY11_00280	ENOG4105WHD	thiamine biosynthesis protein ThiS
HPY11_00285	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPY11_00290	ENOG4105D41	biosynthesis protein thiH
HPY11_00295	ENOG4105DC7	peptidase M24
HPY11_00295	ENOG4105DC7	peptidase M24
HPY11_00300	ENOG4105G2Y	Transcriptional regulator
HPY11_00305	ENOG4105CNH	Multidrug resistance protein MdtL
HPY11_00315	ENOG4108VVK	transcriptional Regulator, AsnC
HPY11_00320	ENOG4105BZU	Histidine kinase
HPY11_00335	ENOG4105EMK	carboxylate amino acid amine transporter
HPY11_00340	ENOG4108M6U	Universal stress protein A
HPY11_00345	ENOG41090A1	ferritin
HPY11_00350	ENOG4108V6B	universal stress protein B
HPY11_00355	ENOG4105CBX	hi0933 family
HPY11_00365	ENOG4105CGY	Dna recombination protein
HPY11_00370	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPY11_00375	ENOG4105JC1	sterol-binding domain protein
HPY11_00385	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY11_00390	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPY11_00395	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPY11_00400	ENOG4107R73	Mate efflux family protein
HPY11_00410	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPY11_00415	ENOG4105E55	glycerol-3-phosphate acyltransferase
HPY11_00420	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HPY11_00425	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HPY11_00430	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY11_00435	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_00445	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HPY11_00450	ENOG4105F8V	Hydrolase, tatD family
HPY11_00455	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPY11_00465	ENOG4105C2M	dna polymerase I
HPY11_00475	ENOG4106RE7	Cytochrome
HPY11_00485	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HPY11_00490	ENOG4105XCT	Protein of unknown function (DUF2489)
HPY11_00495	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY11_00500	ENOG410601J	HemY protein
HPY11_00505	ENOG4105ECF	c-methyltransferase
HPY11_00510	ENOG41076E6	Uroporphyrinogen-III Synthase
HPY11_00515	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPY11_00520	ENOG4107T0K	Adenylate cyclase
HPY11_00525	ENOG4105XQ6	frataxin-like protein
HPY11_00535	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPY11_00540	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPY11_00545	ENOG4105CT0	Protein of unknown function, DUF484
HPY11_00550	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY11_00555	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HPY11_00560	ENOG4105BZU	Histidine kinase
HPY11_00575	ENOG4105DQF	Hydrolase
HPY11_00580	ENOG4108EUD	Lysophospholipase
HPY11_00585	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY11_00590	ENOG4105D58	Diguanylate phosphodiesterase
HPY11_00595	ENOG4108RMU	ferritin dps family protein
HPY11_00625	ENOG4106H78	methyltransferase
HPY11_00630	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPY11_00635	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPY11_00640	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HPY11_00645	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY11_00650	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HPY11_00700	ENOG4108MA7	Inherit from COG: YD repeat protein
HPY11_00740	ENOG4108YGG	dna repair protein
HPY11_00775	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HPY11_00780	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY11_00785	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HPY11_00790	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPY11_00855	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPY11_00860	ENOG4105BZU	Histidine kinase
HPY11_00865	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_00870	ENOG4105CUX	Signal transduction histidine kinase
HPY11_00880	ENOG4105C5F	glutamine synthetase
HPY11_00890	ENOG4105CI3	gtp-binding protein typa
HPY11_00900	ENOG4107S2Z	UPF0761 membrane protein
HPY11_00905	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPY11_00910	ENOG4105SUU	thioesterase domain
HPY11_00920	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HPY11_00925	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HPY11_00930	ENOG4105VEJ	Heat shock protein
HPY11_00935	ENOG4108XKW	General secretion pathway protein C
HPY11_00945	ENOG4107QHF	type ii secretion system protein e
HPY11_00950	ENOG4105D7Q	type ii secretion system
HPY11_00955	ENOG4108VAU	general secretion pathway protein G
HPY11_00960	ENOG4105VWV	general secretion pathway protein h
HPY11_00965	ENOG4105X5Z	General secretion pathway protein I
HPY11_00970	ENOG4108WWZ	General secretion pathway protein J
HPY11_00975	ENOG4108RTD	type II secretion system protein K
HPY11_00980	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HPY11_00985	ENOG4105U1E	general secretion pathway protein M
HPY11_00990	ENOG4105PIC	general secretion pathway protein N
HPY11_00995	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HPY11_01000	ENOG4107RK2	ADP-ribose diphosphatase NudE
HPY11_01010	ENOG4105MJ2	Competence protein
HPY11_01020	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY11_01030	ENOG4105BZM	domain protein
HPY11_01070	ENOG4108RRZ	Transcription elongation factor GreB
HPY11_01075	ENOG4108KHX	Diguanylate cyclase
HPY11_01085	ENOG4105E0F	Histidine kinase
HPY11_01090	ENOG4105C2W	permease
HPY11_01095	ENOG4105CB5	ATP-dependent DNA helicase recG
HPY11_01100	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY11_01105	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HPY11_01110	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPY11_01115	ENOG4105EX9	Membrane
HPY11_01120	ENOG4107QN1	sodium solute
HPY11_01140	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HPY11_01150	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY11_01155	ENOG4108IJ0	Aspartate ammonia-lyase
HPY11_01160	ENOG4105BZU	Histidine kinase
HPY11_01165	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HPY11_01170	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPY11_01180	ENOG4105E0F	Histidine kinase
HPY11_01185	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HPY11_01195	ENOG41076HS	cation diffusion facilitator family transporter
HPY11_01200	ENOG4105CTQ	phosphohexokinase
HPY11_01205	ENOG4105CBT	Fructose-1,6-bisphosphatase
HPY11_01210	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HPY11_01215	ENOG4105SYT	Methylenetetrahydrofolate reductase
HPY11_01220	ENOG4105CFH	Aspartokinase
HPY11_01225	ENOG4105C28	cystathionine
HPY11_01230	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HPY11_01235	ENOG4105C6K	Malic enzyme
HPY11_01240	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPY11_01245	ENOG4105C25	Primosomal protein n'
HPY11_01250	ENOG4105ETE	Transcriptional regulator (LacI family
HPY11_01255	ENOG41063M6	Cell Division Protein
HPY11_01260	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HPY11_01265	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HPY11_01270	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HPY11_01275	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY11_01285	ENOG4105CP7	Triose-phosphate isomerase
HPY11_01310	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY11_01315	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY11_01325	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HPY11_01330	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY11_01340	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HPY11_01345	ENOG4105E33	succinate dehydrogenase
HPY11_01355	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HPY11_01360	ENOG4107YZP	Rhodanese domain protein
HPY11_01365	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HPY11_01370	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPY11_01375	ENOG4105D7W	serine acetyltransferase
HPY11_01385	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HPY11_01390	ENOG4105CWC	Acetylornithine deacetylase
HPY11_01395	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPY11_01400	ENOG4105CAS	nag kinase
HPY11_01405	ENOG4105CDH	Citrulline--aspartate ligase
HPY11_01410	ENOG4105CH7	arginosuccinase
HPY11_01420	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY11_01425	ENOG4105EHV	domain protein
HPY11_01435	ENOG4108JQC	penicillin-binding protein 1A
HPY11_01460	ENOG4105E4G	Type IV pilus
HPY11_01465	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPY11_01470	ENOG4105D49	3-dehydroquinate synthase
HPY11_01480	ENOG4105DFE	Dna adenine methylase
HPY11_01485	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPY11_01490	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY11_01495	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPY11_01515	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HPY11_01520	ENOG4105DDQ	anthranilate synthase
HPY11_01525	ENOG4105C8Y	Acetylornithine aminotransferase
HPY11_01535	ENOG4105C26	Dehydrogenase
HPY11_01545	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HPY11_01550	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HPY11_01560	ENOG4105DNZ	Alpha Beta Hydrolase
HPY11_01570	ENOG4105C5H	ABC transporter
HPY11_01575	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPY11_01590	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HPY11_01595	ENOG4105D44	asparaginase
HPY11_01600	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY11_01605	ENOG4108UV7	flagellar protein motX
HPY11_01610	ENOG4105E68	Sulfatase
HPY11_01615	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY11_01620	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPY11_01625	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPY11_01630	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPY11_01635	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPY11_01640	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPY11_01645	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY11_01650	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPY11_01655	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPY11_01660	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPY11_01665	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HPY11_01670	ENOG41083MP	50s ribosomal protein l29
HPY11_01675	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HPY11_01680	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPY11_01685	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPY11_01690	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY11_01695	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPY11_01700	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HPY11_01705	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HPY11_01710	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HPY11_01715	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPY11_01720	ENOG4105VPB	50S ribosomal protein L30
HPY11_01730	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HPY11_01740	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY11_01745	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPY11_01750	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPY11_01755	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY11_01760	ENOG4108ZT0	50S ribosomal protein l17
HPY11_01770	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY11_01775	ENOG4108UBT	opacity-associated protein
HPY11_01780	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY11_01785	ENOG4107YB6	acetyltransferase, (GNAT) family
HPY11_01790	ENOG4105C1J	atp-dependent rna helicase
HPY11_01800	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HPY11_01805	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPY11_01810	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HPY11_01815	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HPY11_01820	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HPY11_01840	ENOG4105C19	ABC transporter
HPY11_01855	ENOG4108UUE	Transcriptional regulator
HPY11_01860	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPY11_01865	ENOG4105CFU	surface antigen
HPY11_01875	ENOG41066HZ	AIG2-like family
HPY11_01880	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPY11_01890	ENOG4105DFU	Cell wall formation (By similarity)
HPY11_01895	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HPY11_01905	ENOG4106SMU	thiamine transporter membrane protein
HPY11_01910	ENOG4107T0D	ABC, transporter
HPY11_01915	ENOG4105N42	UPF0307 protein
HPY11_01920	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HPY11_01925	ENOG4105CJW	magnesium transporter
HPY11_01930	ENOG41080Z8	PHOSPHOCARRIER protein
HPY11_01935	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPY11_01940	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HPY11_01945	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HPY11_01950	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY11_01955	ENOG4108IUZ	ABC transporter
HPY11_01960	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HPY11_01970	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HPY11_01975	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY11_01985	ENOG4105DHJ	ABC, transporter
HPY11_01990	ENOG4105CY3	ABC transporter, permease
HPY11_01995	ENOG4107PE3	Mammalian cell entry related domain protein
HPY11_02000	ENOG4105E3I	toluene tolerance
HPY11_02010	ENOG4105VFK	BolA family
HPY11_02015	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPY11_02020	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HPY11_02025	ENOG4105KME	endoribonuclease L-psp
HPY11_02035	ENOG4105CXT	aspartate transcarbamylase
HPY11_02045	ENOG4108IAB	Phoh family
HPY11_02050	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
HPY11_02055	ENOG4105D3G	Pseudouridine synthase
HPY11_02060	ENOG4105C5I	Dehydrogenase
HPY11_02065	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPY11_02070	ENOG4105MYG	DNA polymerase iii, chi subunit
HPY11_02075	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY11_02080	ENOG4108M8S	permease YjgP YjgQ family protein
HPY11_02085	ENOG4108K5H	permease YjgP YjgQ family protein
HPY11_02100	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY11_02140	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY11_02145	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY11_02150	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPY11_02170	ENOG41064T2	transcriptional regulator, lysR family
HPY11_02175	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY11_02180	ENOG4105C7K	acetolactate synthase
HPY11_02185	ENOG4108ZP8	Acetolactate synthase small subunit
HPY11_02190	ENOG4105VNT	transposase (IS4 family) protein
HPY11_02195	ENOG4108JQ1	Dehydrogenase
HPY11_02200	ENOG4105E66	phosphoriboisomerase A
HPY11_02205	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HPY11_02215	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HPY11_02225	ENOG4105D0A	hydroxylase
HPY11_02230	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY11_02245	ENOG4105Y75	tpr repeat protein
HPY11_02255	ENOG4108IYU	L-aspartate oxidase
HPY11_02260	ENOG4105EMN	RNA polymerase sigma factor
HPY11_02275	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
HPY11_02280	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPY11_02285	ENOG4105C3F	Signal peptidase i
HPY11_02290	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPY11_02295	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPY11_02300	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HPY11_02305	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HPY11_02330	ENOG4105BZU	Histidine kinase
HPY11_02340	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY11_02345	ENOG4105DXN	mazG family
HPY11_02350	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HPY11_02355	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPY11_02375	ENOG4106MWK	domain protein
HPY11_02380	ENOG4105CJ3	phosphate transporter
HPY11_02385	ENOG4107IX6	phosphate transport regulator
HPY11_02390	ENOG4105I7R	Adenylate cyclase
HPY11_02395	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_02400	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPY11_02405	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HPY11_02410	ENOG4105DFG	type I secretion outer membrane protein
HPY11_02415	ENOG41087AY	ADP-Ribose pyrophosphatase
HPY11_02420	ENOG4108SX3	cytoplasmic protein
HPY11_02425	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HPY11_02430	ENOG4105IPS	esterase
HPY11_02435	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY11_02440	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY11_02450	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HPY11_02455	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPY11_02460	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HPY11_02465	ENOG4105D7Q	type ii secretion system
HPY11_02470	ENOG4107QHF	type ii secretion system protein e
HPY11_02480	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HPY11_02490	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY11_02495	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY11_02500	ENOG4105T95	Thiol disulfide interChange protein
HPY11_02505	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HPY11_02510	ENOG41073TP	transcriptional regulator
HPY11_02515	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPY11_02520	ENOG4107QSN	dihydrolipoamide acetyltransferase
HPY11_02525	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY11_02540	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPY11_02545	ENOG4105CJN	penicillin-binding protein
HPY11_02550	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPY11_02555	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HPY11_02565	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPY11_02575	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HPY11_02580	ENOG4105DFU	Cell wall formation (By similarity)
HPY11_02585	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HPY11_02590	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HPY11_02595	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPY11_02600	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY11_02610	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY11_02615	ENOG4105M6F	mutator MutT protein
HPY11_02620	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPY11_02630	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HPY11_02635	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPY11_02650	ENOG4105EJ9	Membrane
HPY11_02655	ENOG4105VP0	transcriptional regulator, lysR family
HPY11_02660	ENOG4105EN6	Membrane
HPY11_02665	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HPY11_02675	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPY11_02685	ENOG4105BZ8	glutamate synthase
HPY11_02690	ENOG4105CBC	glutamate synthase
HPY11_02705	ENOG4105N5T	Radical SAM Protein
HPY11_02715	ENOG4105BZU	Histidine kinase
HPY11_02720	ENOG41065U4	response regulator
HPY11_02730	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY11_02750	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPY11_02755	ENOG4105D98	threonine synthase
HPY11_02760	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HPY11_02765	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HPY11_02770	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPY11_02785	ENOG4105BZG	amino acid carrier protein
HPY11_02790	ENOG4105D1Q	UPF0246 protein
HPY11_02800	ENOG4105EYA	deoxyribonuclease
HPY11_02805	ENOG4105D9N	nucleoside
HPY11_02815	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HPY11_02820	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HPY11_02825	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HPY11_02830	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY11_02840	ENOG4105EAC	phosphoserine phosphatase
HPY11_02850	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPY11_02855	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY11_02860	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY11_02865	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY11_02875	ENOG4105CNT	hydrolase family 2
HPY11_02885	ENOG4108Y51	tRNA-binding protein
HPY11_02900	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY11_02905	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY11_02915	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HPY11_02920	ENOG4105X2V	dna damage-inducible protein
HPY11_02935	ENOG4105DSY	exodeoxyribonuclease V, gamma
HPY11_02940	ENOG4107QKA	exodeoxyribonuclease V beta
HPY11_02945	ENOG4107QYX	exodeoxyribonuclease v alpha
HPY11_02955	ENOG4107QZM	n-acetylglutamate synthase
HPY11_02965	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HPY11_02970	ENOG4105CUZ	uba thif-type nad fad binding protein
HPY11_02975	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HPY11_02980	ENOG4105C9B	Cysteine desulfurase
HPY11_02985	ENOG4107S0N	DJ-1 family
HPY11_02990	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPY11_02995	ENOG4105DRB	nucleoside-specific channel-forming protein
HPY11_03005	ENOG4105K6V	RNA polymerase
HPY11_03015	ENOG4105EYM	Major Facilitator superfamily
HPY11_03020	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY11_03030	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY11_03035	ENOG4105M85	Bola protein
HPY11_03045	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY11_03050	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY11_03055	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY11_03060	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY11_03065	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HPY11_03070	ENOG4105CJ2	(LipO)protein
HPY11_03090	ENOG4105BZU	Histidine kinase
HPY11_03095	ENOG4105C8J	)-transporter
HPY11_03105	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY11_03110	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY11_03115	ENOG4105CIN	aminoacyl-histidine dipeptidase
HPY11_03120	ENOG4105C7N	Xanthine uracil vitamin C permease
HPY11_03125	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HPY11_03130	ENOG4108DJV	Fermentation respiration switch protein
HPY11_03135	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HPY11_03140	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPY11_03145	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPY11_03150	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPY11_03155	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY11_03170	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HPY11_03175	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HPY11_03180	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HPY11_03185	ENOG4108ZAI	phosphatidylglycerophosphatase a
HPY11_03190	ENOG4108T8E	UPF0325 protein
HPY11_03195	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HPY11_03200	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPY11_03205	ENOG4105CE9	30S ribosomal protein S2
HPY11_03210	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HPY11_03215	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPY11_03220	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPY11_03225	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPY11_03230	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPY11_03235	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPY11_03240	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPY11_03250	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HPY11_03255	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY11_03260	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HPY11_03265	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY11_03270	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY11_03275	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY11_03280	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPY11_03285	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HPY11_03290	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HPY11_03295	ENOG4105N7H	Cytochrome
HPY11_03300	ENOG4105PY6	Phenolic acid decarboxylase
HPY11_03305	ENOG4108YZA	Nitrogen regulatory protein pii
HPY11_03310	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HPY11_03315	ENOG4105E9H	Lytic Murein transglycosylase
HPY11_03320	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPY11_03325	ENOG4105D1A	Methyltransferase
HPY11_03330	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY11_03335	ENOG4107RZZ	dna polymerase iii epsilon subunit
HPY11_03345	ENOG4107QPN	acyl-Coa dehydrogenase
HPY11_03350	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY11_03355	ENOG4105E7A	Glutamine amidotransferase
HPY11_03360	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HPY11_03365	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPY11_03370	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HPY11_03375	ENOG4105BZU	Histidine kinase
HPY11_03380	ENOG4105FE9	pseudouridine synthase
HPY11_03385	ENOG4108DG9	Smr protein MutS2
HPY11_03400	ENOG4105MBR	gumn family
HPY11_03405	ENOG4105E2D	ec 3.2.1.52
HPY11_03415	ENOG4105C59	p-type ATPase
HPY11_03420	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPY11_03425	ENOG4105UYK	outer membrane protein a
HPY11_03435	ENOG4107RBR	Receptor
HPY11_03440	ENOG4105Q26	Siderophore-interacting protein
HPY11_03445	ENOG4105C0W	non-ribosomal peptide synthetase
HPY11_03480	ENOG4107R88	Chemotaxis protein (CheV)
HPY11_03485	ENOG4105BZU	Histidine kinase
HPY11_03490	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPY11_03495	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPY11_03500	ENOG4105W00	Flagellar hook capping protein
HPY11_03505	ENOG4105BZE	flagellar hook protein, FlgE
HPY11_03510	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPY11_03515	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPY11_03520	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY11_03525	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY11_03530	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPY11_03545	ENOG4105I03	Flagellin
HPY11_03550	ENOG4105I03	Flagellin
HPY11_03635	ENOG4105C3G	gtp-binding protein
HPY11_03640	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPY11_03645	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPY11_03650	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPY11_03655	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HPY11_03660	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPY11_03665	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPY11_03670	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPY11_03675	ENOG4108YY7	Invasion gene expression up-regulator SirB
HPY11_03680	ENOG41063JG	Transcriptional regulator
HPY11_03685	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY11_03690	ENOG4105CGH	5'-nucleotidase
HPY11_03695	ENOG4108Z66	YbaK ebsC protein
HPY11_03700	ENOG4105C2W	permease
HPY11_03715	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HPY11_03720	ENOG4105K89	arsenate reductase
HPY11_03725	ENOG4105ERG	peptidase m48, ste24p
HPY11_03740	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_03745	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY11_03760	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY11_03780	ENOG4105KUZ	arsenate reductase
HPY11_03795	ENOG4105QZU	Inner membrane protein YfeZ
HPY11_03800	ENOG4105EZR	dyp-type peroxidase family protein
HPY11_03805	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HPY11_03810	ENOG4105E2D	ec 3.2.1.52
HPY11_03815	ENOG4108UHU	Aldolase
HPY11_03825	ENOG4108IA2	Sodium pantothenate symporter
HPY11_03845	ENOG4105CHC	glucokinase (EC 2.7.1.2)
HPY11_03850	ENOG4105I03	Flagellin
HPY11_03855	ENOG4105I03	Flagellin
HPY11_03860	ENOG4105I03	Flagellin
HPY11_03865	ENOG41063QE	flagellar protein FlaG
HPY11_03870	ENOG4107W9T	flagellar hook-associated
HPY11_03880	ENOG4105MQ3	flagellar protein FliS
HPY11_03890	ENOG4105BZU	Histidine kinase
HPY11_03900	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HPY11_03905	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPY11_03910	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY11_03920	ENOG4108JIR	Flagellum-specific ATP synthase
HPY11_03940	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY11_03945	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY11_03950	ENOG4105DD5	Flagellar motor switch protein
HPY11_03955	ENOG4105VTB	flagellar biosynthesis protein fliO
HPY11_03960	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPY11_03965	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPY11_03970	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPY11_03975	ENOG4105D00	flagellar biosynthetic protein flhB
HPY11_03980	ENOG4108DG9	Smr protein MutS2
HPY11_03985	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HPY11_03990	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPY11_03995	ENOG4105EN6	Membrane
HPY11_04000	ENOG4108BPE	-transporting atpase
HPY11_04005	ENOG4105MH2	YfcL protein
HPY11_04010	ENOG4105Q8W	reductase
HPY11_04015	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HPY11_04020	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY11_04025	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HPY11_04030	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY11_04035	ENOG41090R7	Ferric uptake
HPY11_04045	ENOG4105CMU	LysR family (Transcriptional regulator
HPY11_04050	ENOG4105VAW	lrga family
HPY11_04055	ENOG41067MG	lrgb family
HPY11_04060	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY11_04070	ENOG4105EV9	Alpha Beta Hydrolase
HPY11_04075	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HPY11_04080	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HPY11_04090	ENOG4107QNR	UPF0135 protein
HPY11_04095	ENOG4105BZN	citrate synthase
HPY11_04100	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HPY11_04105	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HPY11_04110	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HPY11_04115	ENOG4105E33	succinate dehydrogenase
HPY11_04120	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPY11_04125	ENOG4105C7S	Dehydrogenase
HPY11_04130	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HPY11_04135	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HPY11_04140	ENOG4105FAV	ABC, transporter
HPY11_04145	ENOG4105FDK	ABC transporter
HPY11_04150	ENOG4105NXV	High-affinity zinc uptake system protein
HPY11_04155	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HPY11_04160	ENOG4105XFK	Ferrous iron transport protein A
HPY11_04180	ENOG4105C75	arginyL-tRNA synthetase
HPY11_04190	ENOG4108JQM	Insulinase (Peptidase family M16)
HPY11_04195	ENOG4108BY2	phosphohistidine phosphatase
HPY11_04200	ENOG4105D7B	Flagellar biosynthesis protein flha
HPY11_04205	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HPY11_04215	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY11_04220	ENOG4108VYJ	response regulator receiver protein
HPY11_04225	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HPY11_04235	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY11_04240	ENOG4107QJE	Chromosome Partitioning Protein
HPY11_04250	ENOG4108V3W	Chemotaxis protein, CheW
HPY11_04260	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HPY11_04265	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HPY11_04270	ENOG41060IM	Heme exporter protein
HPY11_04275	ENOG41067VX	Heme exporter protein
HPY11_04280	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HPY11_04285	ENOG4105DA4	cytochrome c-type biogenesis protein
HPY11_04290	ENOG4107QX9	Thiol disulfide interChange protein
HPY11_04295	ENOG4105KWW	Biogenesis protein
HPY11_04305	ENOG410903C	(LipO)protein
HPY11_04320	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY11_04325	ENOG4105M2J	Glutaredoxin
HPY11_04330	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY11_04335	ENOG4105DGU	Histone deacetylase
HPY11_04350	ENOG4105E68	Sulfatase
HPY11_04355	ENOG4105YDX	UPF0352 protein
HPY11_04360	ENOG4106V8H	Nucleoid-associated protein
HPY11_04370	ENOG4105DFD	Na H antiporter
HPY11_04375	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY11_04380	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPY11_04385	ENOG4105C0A	alcohol dehydrogenase
HPY11_04395	ENOG4105CHH	sulfate transporter
HPY11_04400	ENOG4105C03	ribonuclease
HPY11_04405	ENOG4105EI2	Pseudouridine synthase
HPY11_04410	ENOG4108UHJ	MAF-like protein
HPY11_04415	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HPY11_04420	ENOG4105VGS	50s ribosomal protein l32
HPY11_04425	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HPY11_04430	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY11_04435	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HPY11_04440	ENOG4105CHR	reductase
HPY11_04445	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPY11_04450	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY11_04455	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HPY11_04460	ENOG4105HHA	aminodeoxychorismate lyase
HPY11_04465	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPY11_04470	ENOG4107QRG	dna polymerase iii
HPY11_04475	ENOG4105F8V	Hydrolase, tatD family
HPY11_04480	ENOG4105CI1	PTS System
HPY11_04490	ENOG4105C8J	)-transporter
HPY11_04505	ENOG4108NRW	Phospholipase, patatin family
HPY11_04510	ENOG4105CA9	Pyruvate kinase
HPY11_04515	ENOG4105DAG	ROK family
HPY11_04535	ENOG4105DHI	Methyltransferase
HPY11_04545	ENOG4105DSB	aldose 1-epimerase
HPY11_04550	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY11_04555	ENOG4105E0X	reductase
HPY11_04565	ENOG4105VUT	cytoplasmic protein
HPY11_04570	ENOG4105HDK	L-asparaginase
HPY11_04575	ENOG4105D07	Signal peptide peptidase, SppA
HPY11_04580	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY11_04585	ENOG4105CIY	formyltetrahydrofolate deformylase
HPY11_04595	ENOG4105DVT	helicase
HPY11_04600	ENOG41072GX	Peptidase M22 Glycoprotease
HPY11_04615	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY11_04620	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY11_04625	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HPY11_04640	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY11_04645	ENOG4105DK2	UPF0207 protein
HPY11_04650	ENOG4105CHM	Aminotransferase
HPY11_04655	ENOG4105E4F	Isochorismate synthase
HPY11_04660	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPY11_04665	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HPY11_04670	ENOG4108IPT	Naphthoate synthase
HPY11_04680	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY11_04685	ENOG4105DKK	Benzoate
HPY11_04690	ENOG4107S74	Lysophospholipid transporter LplT
HPY11_04715	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HPY11_04720	ENOG4107QMS	site-determining protein
HPY11_04725	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HPY11_04730	ENOG4105VNG	YcgL domain-containing protein
HPY11_04735	ENOG4105CVE	Lytic murein transglycosylase
HPY11_04740	ENOG4105JQN	Transcriptional regulator
HPY11_04745	ENOG4105D9N	nucleoside
HPY11_04750	ENOG4105CUW	cytochrome C-TYPE protein
HPY11_04755	ENOG4107QY8	reductase
HPY11_04765	ENOG4105JQN	Transcriptional regulator
HPY11_04785	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HPY11_04820	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPY11_04830	ENOG4105BZU	Histidine kinase
HPY11_04840	ENOG4105CNG	UPF0061 protein
HPY11_04845	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPY11_04850	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HPY11_04855	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY11_04860	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_04875	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPY11_04880	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPY11_04885	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPY11_04890	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HPY11_04895	ENOG4105K70	DNA-binding protein
HPY11_04900	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HPY11_04905	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HPY11_04910	ENOG4105CAT	Cytidine monophosphate kinase
HPY11_04915	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPY11_04920	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY11_04925	ENOG4105Q4A	inner membrane protein yciS
HPY11_04930	ENOG4105CFV	Tetratricopeptide repeat protein
HPY11_04940	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HPY11_04950	ENOG4107R11	Transcriptional regulator
HPY11_04960	ENOG4105DCF	alanine dehydrogenase
HPY11_04965	ENOG4105EW9	transcriptional regulator AsnC family
HPY11_04970	ENOG4105CNU	cell division protein FtsK
HPY11_04975	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HPY11_04980	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY11_04985	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HPY11_04995	ENOG4108NVR	Methyl-accepting chemotaxis
HPY11_05000	ENOG4105K59	histidine triad (HIT) protein
HPY11_05025	ENOG4105D0Y	UPF0227 protein
HPY11_05030	ENOG4105CEP	NADH dehydrogenase
HPY11_05045	ENOG4106M3D	hemolysin
HPY11_05055	ENOG4108JA2	transcriptioN-repair coupling factor
HPY11_05065	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY11_05070	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY11_05075	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY11_05085	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HPY11_05090	ENOG4105BZ1	(ABC) transporter
HPY11_05095	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HPY11_05100	ENOG4105W49	UPF0434 protein
HPY11_05105	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY11_05110	ENOG4105ED1	spovr family
HPY11_05115	ENOG4106AKX	UPF0229 protein
HPY11_05120	ENOG4105CYN	Serine protein kinase
HPY11_05125	ENOG4105XWI	UPF0304 protein
HPY11_05135	ENOG4105F1A	Pyruvate formate-lyase
HPY11_05140	ENOG4108N3W	hemolysin secretion protein
HPY11_05150	ENOG4105C6N	Formate acetyltransferase
HPY11_05160	ENOG4108JEH	abc transporter atp-binding protein
HPY11_05165	ENOG4105E89	ABC transporter
HPY11_05170	ENOG4105DSP	amino acid AbC transporter
HPY11_05175	ENOG4106YG3	ABC transporter
HPY11_05180	ENOG4105CGK	Exodeoxyribonuclease III
HPY11_05185	ENOG4106428	Protein of unknown function (DUF2496)
HPY11_05190	ENOG4108URS	primosomal replication protein n''
HPY11_05195	ENOG4105EJ9	Membrane
HPY11_05200	ENOG4105DVT	helicase
HPY11_05215	ENOG4105K5B	UPF0225 protein
HPY11_05220	ENOG4105D58	Diguanylate phosphodiesterase
HPY11_05225	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HPY11_05230	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY11_05235	ENOG4105C8N	cysteinyl-tRNA synthetase
HPY11_05240	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPY11_05245	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPY11_05255	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY11_05260	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY11_05270	ENOG4105KJB	cyd operon protein YbgE
HPY11_05275	ENOG4107YD3	Thioesterase
HPY11_05280	ENOG4105E02	MotA TolQ exbB proton channel
HPY11_05285	ENOG4105M8F	Biopolymer transport protein exbD tolR
HPY11_05295	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HPY11_05300	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HPY11_05310	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HPY11_05320	ENOG4105BZU	Histidine kinase
HPY11_05325	ENOG4108RNS	Exports L-alanine (By similarity)
HPY11_05330	ENOG4105EIP	mannose-6-phosphate isomerase
HPY11_05335	ENOG4105DM4	PTS System
HPY11_05340	ENOG4106R3P	AraC family transcriptional regulator
HPY11_05350	ENOG4108YRF	PTS System
HPY11_05355	ENOG4105DM4	PTS System
HPY11_05360	ENOG4105DM4	PTS System
HPY11_05370	ENOG4105C26	Dehydrogenase
HPY11_05375	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HPY11_05380	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY11_05390	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY11_05425	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HPY11_05435	ENOG4105DY2	Paraquat-inducible protein b
HPY11_05440	ENOG4105F1S	paraquat-inducible protein a
HPY11_05465	ENOG4108R86	Transcriptional regulator
HPY11_05470	ENOG4105C26	Dehydrogenase
HPY11_05475	ENOG4105MTM	Protein of unknown function (DUF1496)
HPY11_05485	ENOG41067SE	Tetr family transcriptional regulator
HPY11_05490	ENOG4107QPN	acyl-Coa dehydrogenase
HPY11_05500	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPY11_05510	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HPY11_05520	ENOG4105RKX	Protein of unknown function (DUF2498)
HPY11_05525	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY11_05530	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY11_05535	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPY11_05555	ENOG4105HP8	regulator of competence-specific genes
HPY11_05560	ENOG4105ETE	Transcriptional regulator (LacI family
HPY11_05570	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HPY11_05575	ENOG4107S90	membrAne
HPY11_05580	ENOG4106371	Methyltransferase
HPY11_05585	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HPY11_05590	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HPY11_05600	ENOG4105EW9	transcriptional regulator AsnC family
HPY11_05605	ENOG4108VP3	Lysine exporter protein (LysE YggA)
HPY11_05610	ENOG4105CCT	upf0313 protein
HPY11_05635	ENOG4105DZ2	Transcriptional regulator
HPY11_05640	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HPY11_05650	ENOG4105K9H	YciI-like protein
HPY11_05655	ENOG4105NAU	thioesterase Superfamily protein
HPY11_05670	ENOG4105GFG	DUF218 domain
HPY11_05675	ENOG4107SRH	Nad-dependent epimerase dehydratase
HPY11_05685	ENOG4105TMB	Formate nitrite transporter
HPY11_05700	ENOG4107QY8	reductase
HPY11_05720	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HPY11_05740	ENOG4108JQ2	peptide transport system atp-binding protein
HPY11_05745	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HPY11_05750	ENOG4108EU3	peptide transport system, permease
HPY11_05755	ENOG4108I5W	peptide transport system, permease protein
HPY11_05760	ENOG4108J59	Extracellular solute-binding protein, family 5
HPY11_05765	ENOG4105E51	psp operon transcriptional activator
HPY11_05770	ENOG41087YS	Phage shock protein A
HPY11_05785	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPY11_05800	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HPY11_05805	ENOG4105C28	cystathionine
HPY11_05815	ENOG4105C8J	)-transporter
HPY11_05820	ENOG41065KQ	synthase
HPY11_05840	ENOG4108W1A	pseudouridine synthase
HPY11_05845	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HPY11_05850	ENOG4108VGW	abc transporter atp-binding protein
HPY11_05855	ENOG4105CXZ	ABC transporter, permease
HPY11_05860	ENOG4105VNH	ABC transporter solute-binding protein
HPY11_05870	ENOG4105XZD	Fe-S protein
HPY11_05880	ENOG4105C44	Serine transporter
HPY11_05890	ENOG4105CJW	magnesium transporter
HPY11_05900	ENOG4105BZU	Histidine kinase
HPY11_05910	ENOG4105KXC	Collagenase
HPY11_05945	ENOG4108N3W	hemolysin secretion protein
HPY11_05960	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPY11_05980	ENOG4105CFI	type iii restriction protein res subunit
HPY11_05985	ENOG4105I08	Pseudouridine synthase
HPY11_05990	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY11_06000	ENOG4105CGD	Nad-dependent epimerase dehydratase
HPY11_06005	ENOG4105UQX	Mate efflux family protein
HPY11_06010	ENOG4108I0Y	(ABC) transporter
HPY11_06025	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY11_06035	ENOG4105E3Q	saccharopine dehydrogenase
HPY11_06040	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HPY11_06045	ENOG4105CDV	Ompa motb domain protein
HPY11_06050	ENOG4105DFG	type I secretion outer membrane protein
HPY11_06110	ENOG4105F04	LysR family Transcriptional regulator
HPY11_06120	ENOG4108VKG	metal-dependent hydrolase
HPY11_06125	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HPY11_06135	ENOG41090FY	type IV pilus biogenesis stability protein PilW
HPY11_06140	ENOG4105CVG	Homoserine O-transsuccinylase
HPY11_06160	ENOG4107V40	secretion protein, HlyD family
HPY11_06175	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY11_06180	ENOG4106YYS	transcriptional regulatory protein
HPY11_06190	ENOG4107R88	Chemotaxis protein (CheV)
HPY11_06240	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPY11_06245	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPY11_06250	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPY11_06260	ENOG4105C7K	acetolactate synthase
HPY11_06265	ENOG4107FQX	Alpha-acetolactate decarboxylase
HPY11_06275	ENOG4105F88	accessory colonization factor AcfD
HPY11_06285	ENOG4105CH6	catalase
HPY11_06295	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY11_06305	ENOG4108TWJ	NADH dehydrogenase subunit 5
HPY11_06310	ENOG4105DUM	transcriptional regulator, lysR family
HPY11_06315	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
HPY11_06330	ENOG4105V0I	UPF0267 protein
HPY11_06345	ENOG4105C9Q	fumarate hydratase class II
HPY11_06355	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY11_06360	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY11_06365	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY11_06370	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY11_06375	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY11_06385	ENOG4107QZV	Type I secretion membrane fusion protein
HPY11_06425	ENOG4105CVN	desaturase
HPY11_06450	ENOG4108M8W	Monooxygenase
HPY11_06455	ENOG4108XDE	Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis
HPY11_06465	ENOG4105E09	nadh pyrophosphatase
HPY11_06470	ENOG4106MXH	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY11_06485	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY11_06495	ENOG4105CS2	ec 3.2.1.21
HPY11_06500	ENOG4105DDV	Transcriptional regulator (LacI family
HPY11_06505	ENOG4105M4H	endoribonuclease L-psp
HPY11_06510	ENOG4105XEP	YhcH YjgK YiaL family protein
HPY11_06515	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HPY11_06520	ENOG4105E98	transcriptional regulator DeoR family
HPY11_06525	ENOG4108IJ9	(ABC) transporter
HPY11_06530	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HPY11_06535	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HPY11_06560	ENOG4109015	Biopolymer transport protein exbD tolR
HPY11_06565	ENOG41067XB	TonB family
HPY11_06585	ENOG4107QI1	Mate efflux family protein
HPY11_06605	ENOG4107TT5	NLP P60 protein
HPY11_06610	ENOG4108N3W	hemolysin secretion protein
HPY11_06620	ENOG4106IUH	DTW domain containing protein
HPY11_06625	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HPY11_06635	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY11_06640	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HPY11_06645	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY11_06650	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HPY11_06660	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_06665	ENOG4105BZU	Histidine kinase
HPY11_06670	ENOG4105C5H	ABC transporter
HPY11_06680	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPY11_06700	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY11_06710	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY11_06715	ENOG4105QAX	Iron-sulfur
HPY11_06730	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HPY11_06735	ENOG4108VPT	UPF0234 protein
HPY11_06740	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY11_06755	ENOG4105QNR	S1 RNA binding domain protein
HPY11_06765	ENOG4105DY2	Paraquat-inducible protein b
HPY11_06770	ENOG4105H2K	paraquat-inducible protein a
HPY11_06775	ENOG4105BZ1	(ABC) transporter
HPY11_06780	ENOG4108ZGC	gaf domain protein
HPY11_06785	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HPY11_06790	ENOG4105CN1	protease
HPY11_06800	ENOG4105CD8	aminopeptidase N
HPY11_06810	ENOG4105C7I	Dehydrogenase
HPY11_06815	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPY11_06820	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HPY11_06825	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HPY11_06835	ENOG4105C5H	ABC transporter
HPY11_06850	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HPY11_06855	ENOG4105DAN	ATP-dependent protease
HPY11_06860	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
HPY11_06935	ENOG4108RC6	RTX toxin
HPY11_06960	ENOG4105BZU	Histidine kinase
HPY11_06975	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HPY11_06990	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HPY11_07000	ENOG4105C59	p-type ATPase
HPY11_07015	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HPY11_07020	ENOG4105Q9Y	Universal stress protein
HPY11_07025	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HPY11_07045	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY11_07055	ENOG4105D38	putrescine abc transporter
HPY11_07060	ENOG4108HM4	ABC transporter
HPY11_07065	ENOG4107RUE	extracellular solute-binding protein family 1
HPY11_07080	ENOG4105BZG	amino acid carrier protein
HPY11_07085	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY11_07115	ENOG4105CS6	Rhs element vgr protein
HPY11_07120	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY11_07125	ENOG4105CTD	carboxy-peptidase
HPY11_07140	ENOG4105C26	Dehydrogenase
HPY11_07145	ENOG4107THI	3,4-dihydroxyphenylacetate 2,3-dioxygenase
HPY11_07170	ENOG4105ERH	Fumarylacetoacetate hydrolase
HPY11_07175	ENOG4105CNV	Aldolase
HPY11_07195	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY11_07200	ENOG4108V8F	Transcriptional regulator, MarR family
HPY11_07205	ENOG4107UWN	reductase
HPY11_07260	ENOG4105C1J	atp-dependent rna helicase
HPY11_07270	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY11_07275	ENOG4105EJC	lysr family transcriptional regulator
HPY11_07285	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HPY11_07290	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HPY11_07295	ENOG4105R8A	Heat shock protein
HPY11_07305	ENOG4105CQ7	ATP-dependent helicase
HPY11_07325	ENOG4105BZU	Histidine kinase
HPY11_07335	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY11_07340	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY11_07345	ENOG4105BZU	Histidine kinase
HPY11_07355	ENOG4105BZU	Histidine kinase
HPY11_07375	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HPY11_07380	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HPY11_07385	ENOG410667J	hydrolase
HPY11_07395	ENOG4107QXX	ABC transporter
HPY11_07400	ENOG4105EZ7	amino acid ABC transporter
HPY11_07405	ENOG4105DRP	amino acid AbC transporter
HPY11_07410	ENOG4105CDA	abc transporter atp-binding protein
HPY11_07415	ENOG4108MN8	Membrane
HPY11_07420	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HPY11_07425	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HPY11_07435	ENOG4106TD9	Diguanylate cyclase
HPY11_07445	ENOG4105BZU	Histidine kinase
HPY11_07450	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY11_07455	ENOG4108RXX	maleylacetoacetate isomerase
HPY11_07465	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HPY11_07470	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPY11_07475	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY11_07490	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY11_07495	ENOG4105C7F	AcnD-accessory protein PrpF
HPY11_07500	ENOG4108I0Z	Aconitate hydratase
HPY11_07505	ENOG4105BZN	citrate synthase
HPY11_07510	ENOG4105CR4	methylisocitrate lyase
HPY11_07535	ENOG4108PTX	LysR family Transcriptional regulator
HPY11_07540	ENOG4105D05	Receptor
HPY11_07565	ENOG4105EFX	secretion protein, HlyD family
HPY11_07580	ENOG4107SDZ	Galactoside transport system permease protein mglC
HPY11_07585	ENOG4105C2J	ABC transporter
HPY11_07610	ENOG4107EXC	regulatoR
HPY11_07615	ENOG4105GR3	Histidine kinase
HPY11_07620	ENOG4105RW8	MltA-interacting MipA family protein
HPY11_07625	ENOG4108MJ5	VirK protein
HPY11_07630	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_07635	ENOG4105BZU	Histidine kinase
HPY11_07640	ENOG4105C8P	)-transporter
HPY11_07645	ENOG4108NVR	Methyl-accepting chemotaxis
HPY11_07650	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY11_07665	ENOG4105D9U	N-acetyltransferase
HPY11_07670	ENOG4108JU8	Transcriptional regulator
HPY11_07680	ENOG4105CM6	amino acid regulated cytosolic protein
HPY11_07695	ENOG4105CRQ	synthase (Component I)
HPY11_07700	ENOG4105P8F	nudix hydrolase
HPY11_07705	ENOG4105C44	Serine transporter
HPY11_07710	ENOG4105EJQ	L-serine dehydratase
HPY11_07715	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HPY11_07720	ENOG4108N3W	hemolysin secretion protein
HPY11_07725	ENOG4105C5S	asparaginyl-tRNA synthetase
HPY11_07735	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY11_07740	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY11_07755	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_07760	ENOG4105DJ9	glucan biosynthesis protein
HPY11_07765	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HPY11_07770	ENOG4105C94	Transporter
HPY11_07775	ENOG41067TZ	transcriptional regulator, MarR family
HPY11_07790	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY11_07800	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY11_07815	ENOG4105C5X	domain protein
HPY11_07820	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HPY11_07850	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HPY11_07860	ENOG4105S8Q	sugar efflux transporter
HPY11_07870	ENOG4105C72	UPF0176 protein
HPY11_07875	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY11_07880	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPY11_07885	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY11_07890	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY11_07895	ENOG4107QK7	reductase
HPY11_07920	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_07935	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HPY11_07940	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HPY11_07955	ENOG4108YZT	Adenosylcobinamide kinase
HPY11_07960	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HPY11_07965	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HPY11_07970	ENOG4105E0X	reductase
HPY11_07975	ENOG4108ETY	sodium dicarboxylate symporter
HPY11_07980	ENOG4105CJB	Exodeoxyribonuclease I
HPY11_07985	ENOG4105VAW	lrga family
HPY11_07990	ENOG41067MG	lrgb family
HPY11_08010	ENOG4105FQ6	thiopurine methyltransferase
HPY11_08020	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY11_08025	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HPY11_08030	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPY11_08070	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPY11_08075	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY11_08080	ENOG4105CQ2	DNA polymerase
HPY11_08095	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY11_08100	ENOG4108W5H	UPF0263 protein
HPY11_08110	ENOG4105CZE	histidine utilization repressor
HPY11_08115	ENOG4105CI2	imidazolone-5-propionate hydrolase
HPY11_08120	ENOG41088SP	formiminoglutamate hydrolase
HPY11_08125	ENOG4105CGP	Urocanate hydratase
HPY11_08130	ENOG4105C84	Histidine ammonia-lyase
HPY11_08140	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
HPY11_08150	ENOG4105CQB	FAD linked oxidase domain protein
HPY11_08165	ENOG4108ZG0	Ompa motb domain protein
HPY11_08185	ENOG4105C8V	SAICAR synthetase
HPY11_08195	ENOG4107R1I	NAD-dependent malic enzyme
HPY11_08205	ENOG4107GZ4	SanA protein
HPY11_08210	ENOG4105BZU	Histidine kinase
HPY11_08215	ENOG4105C9B	Cysteine desulfurase
HPY11_08225	ENOG4105C3M	thioredoxin reductase
HPY11_08230	ENOG4108JJ9	ABC, transporter
HPY11_08235	ENOG4108JJ8	(ABC) transporter
HPY11_08240	ENOG4105FE9	pseudouridine synthase
HPY11_08245	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPY11_08250	ENOG4105DB7	PHP domain protein
HPY11_08260	ENOG4105CRQ	synthase (Component I)
HPY11_08265	ENOG4105DDQ	anthranilate synthase
HPY11_08270	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPY11_08275	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPY11_08280	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPY11_08285	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPY11_08290	ENOG4105CK2	sodium dicarboxylate symporter
HPY11_08295	ENOG4107104	thymidine kinase
HPY11_08300	ENOG4105C9M	aspartyl-trna synthetase
HPY11_08305	ENOG41081XQ	Conserved Protein
HPY11_08310	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HPY11_08315	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HPY11_08320	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY11_08335	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPY11_08345	ENOG4105CUX	Signal transduction histidine kinase
HPY11_08370	ENOG4105DWU	Membrane
HPY11_08380	ENOG4105DY8	decarboxylase
HPY11_08385	ENOG4106KNT	transcriptional regulator
HPY11_08390	ENOG4105C0A	alcohol dehydrogenase
HPY11_08395	ENOG41090BQ	Glutaredoxin
HPY11_08400	ENOG4105D0C	transport protein
HPY11_08405	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY11_08410	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPY11_08415	ENOG4105VEQ	Cold shock protein
HPY11_08425	ENOG4108R99	pseudouridine synthase
HPY11_08430	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HPY11_08435	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPY11_08440	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY11_08445	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HPY11_08450	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPY11_08455	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPY11_08460	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPY11_08465	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPY11_08470	ENOG4107S6Z	Na H antiporter
HPY11_08480	ENOG4107RE1	Inosine-guanosine kinase
HPY11_08485	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPY11_08490	ENOG41075W9	High frequency lysogenization protein HflD homolog
HPY11_08495	ENOG4107QTF	adenylosuccinate lyase
HPY11_08505	ENOG4105RHG	
HPY11_08515	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HPY11_08530	ENOG4107FW0	short-chain dehydrogenase reductase
HPY11_08540	ENOG4105D0M	Protease HtpX homolog
HPY11_08550	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HPY11_08555	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HPY11_08560	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY11_08565	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HPY11_08570	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HPY11_08575	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPY11_08580	ENOG4105D1H	recombination factor protein RarA
HPY11_08590	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY11_08595	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HPY11_08600	ENOG4105BZU	Histidine kinase
HPY11_08605	ENOG4108JJB	ABC transporter
HPY11_08610	ENOG4105C7J	ABC transporter, permease
HPY11_08620	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY11_08625	ENOG4105PQ6	UPF0208 membrane protein
HPY11_08630	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY11_08635	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HPY11_08640	ENOG4105CHF	Glutathione S-transferase
HPY11_08645	ENOG4108JQ7	(ABC) transporter
HPY11_08650	ENOG4105C3U	ABC transporter
HPY11_08655	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY11_08660	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY11_08665	ENOG4107QSI	ABC, transporter
HPY11_08680	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_08685	ENOG4105BZU	Histidine kinase
HPY11_08690	ENOG4105BZU	Histidine kinase
HPY11_08695	ENOG4105BZU	Histidine kinase
HPY11_08705	ENOG4107YTP	response regulator receiver protein
HPY11_08720	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY11_08735	ENOG4108V1U	phospholipid-binding protein
HPY11_08760	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY11_08765	ENOG41082YX	Transcriptional regulator, arsr family
HPY11_08785	ENOG4105KT5	UmuD protein
HPY11_08835	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPY11_08875	ENOG4105BZU	Histidine kinase
HPY11_08895	ENOG4105C29	acyl-CoA thioesterase
HPY11_08900	ENOG4108XM1	transcriptional regulator AsnC family
HPY11_08910	ENOG4105ERU	peptidase
HPY11_08915	ENOG4105UBK	short-chain dehydrogenase reductase
HPY11_08920	ENOG4108ZZ3	UPF0260 protein
HPY11_08925	ENOG4105KRS	Proteinase inhibitor
HPY11_08930	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HPY11_08935	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HPY11_08940	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HPY11_08945	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPY11_08950	ENOG4105WD1	Membrane
HPY11_08955	ENOG4105I93	response regulator
HPY11_08960	ENOG4105EJC	lysr family transcriptional regulator
HPY11_08965	ENOG41069NU	Nitroreductase
HPY11_08970	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY11_08975	ENOG4105CHU	acetyl-coa acetyltransferase
HPY11_08990	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY11_08995	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY11_09005	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HPY11_09010	ENOG4108GAE	asmA family
HPY11_09015	ENOG4105DBI	uridine monophosphokinase
HPY11_09020	ENOG4105D1F	ATP-binding protein
HPY11_09025	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPY11_09035	ENOG4108I5U	Uridine phosphorylase
HPY11_09050	ENOG4105BZU	Histidine kinase
HPY11_09055	ENOG4108ZAF	Molybdopterin
HPY11_09060	ENOG4105M00	molybdopterin converting factor, subunit 1
HPY11_09065	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY11_09070	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HPY11_09075	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY11_09080	ENOG4105CHW	UPF0052 protein
HPY11_09090	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_09095	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HPY11_09110	ENOG4108R3D	Electron transport complex
HPY11_09130	ENOG4105DZB	Electron transport complex
HPY11_09135	ENOG4105CSM	endonuclease III
HPY11_09140	ENOG4108UYE	Lactoylglutathione lyase
HPY11_09145	ENOG4106WH9	Protein of unknown function (DUF2753)
HPY11_09150	ENOG4105EIY	sodium-type flagellar protein motY
HPY11_09155	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HPY11_09160	ENOG4105D3Y	Na H antiporter
HPY11_09165	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HPY11_09170	ENOG4105E96	Colicin v production protein
HPY11_09175	ENOG4108S3P	Sporulation domain protein
HPY11_09180	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPY11_09185	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HPY11_09190	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPY11_09205	ENOG4105CI1	PTS System
HPY11_09210	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY11_09215	ENOG4105E2R	ROK family
HPY11_09220	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPY11_09225	ENOG4105CAQ	asparagine synthetase
HPY11_09230	ENOG4105MDZ	Transcriptional activator rfaH
HPY11_09235	ENOG4105DUX	Transporter
HPY11_09240	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPY11_09245	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPY11_09250	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HPY11_09255	ENOG4108TU9	TRANSCRIPTIONal
HPY11_09270	ENOG4108RE9	Phosphodiesterase
HPY11_09275	ENOG4105ECP	epimerase
HPY11_09280	ENOG4105E1F	short-chain dehydrogenase reductase
HPY11_09285	ENOG4107QR8	Thioredoxin
HPY11_09290	ENOG4107QX8	SPFH domain, Band 7 family protein
HPY11_09295	ENOG4105G5H	Membrane
HPY11_09300	ENOG4108Z6Z	Transcriptional regulator
HPY11_09310	ENOG41081QG	Porin Gram-negative type
HPY11_09315	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPY11_09320	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HPY11_09325	ENOG4105EXN	Sulfate transport protein CysZ
HPY11_09330	ENOG4105C6T	cysteine synthase
HPY11_09335	ENOG4105KZ7	phosphocarrier protein hpr
HPY11_09340	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPY11_09345	ENOG4105C5Y	PTS System
HPY11_09350	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY11_09355	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HPY11_09360	ENOG4105C9A	Phoh family
HPY11_09370	ENOG4108JU5	Magnesium and cobalt efflux protein
HPY11_09375	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HPY11_09380	ENOG4107PAI	alpha helical protein
HPY11_09385	ENOG4105C8T	Leucyl-tRNA synthetase
HPY11_09390	ENOG4108U2H	Rare lipoprotein B
HPY11_09395	ENOG4105DJF	DNA polymerase III, delta' subunit
HPY11_09400	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HPY11_09405	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HPY11_09410	ENOG4105CJN	penicillin-binding protein
HPY11_09415	ENOG4105CNI	cell division protein FtsW
HPY11_09420	ENOG4105K6T	rare lipoprotein A
HPY11_09425	ENOG4105DZ1	carboxypeptidase
HPY11_09430	ENOG4108Z43	UPF0250 protein
HPY11_09435	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HPY11_09440	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPY11_09450	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY11_09470	ENOG4105D75	Capsular exopolysaccharide family
HPY11_09475	ENOG4105DAY	polysaccharide export protein
HPY11_09485	ENOG4105D3Q	Sugar transferase
HPY11_09500	ENOG4108MA4	Peptidase M66
HPY11_09515	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HPY11_09525	ENOG4107STW	synthase
HPY11_09535	ENOG4105D7W	serine acetyltransferase
HPY11_09555	ENOG4108UW5	maltose o-acetyltransferase
HPY11_09565	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY11_09570	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
HPY11_09575	ENOG4105BZS	acriflavin resistance protein
HPY11_09605	ENOG4105CG3	alpha amylase, catalytic region
HPY11_09610	ENOG4105C5Y	PTS System
HPY11_09615	ENOG4105D4X	repressor
HPY11_09620	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HPY11_09625	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HPY11_09630	ENOG4108UMI	ABC transporter, permease
HPY11_09635	ENOG4105D01	(LipO)protein
HPY11_09640	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HPY11_09645	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HPY11_09650	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HPY11_09660	ENOG4105BZU	Histidine kinase
HPY11_09665	ENOG4105EWT	decarboxylase family
HPY11_09670	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HPY11_09675	ENOG4105M08	Membrane
HPY11_09680	ENOG4105ETT	transcriptional Regulator, LysR family
HPY11_09685	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HPY11_09690	ENOG4106VK6	Flagellar motor protein
HPY11_09695	ENOG4105E14	MotA TolQ exbB proton channel
HPY11_09705	ENOG4105CTB	Polyprenyl synthetase
HPY11_09710	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HPY11_09715	ENOG4105DR9	pseudouridine synthase
HPY11_09720	ENOG4105WP7	tRNA pseudouridine synthase C
HPY11_09735	ENOG4108428	Inherit from COG: -acetyltransferase
HPY11_09745	ENOG4108UPT	UPF0178 protein
HPY11_09750	ENOG4105VNT	transposase (IS4 family) protein
HPY11_09755	ENOG4105CFC	Transporter
HPY11_09765	ENOG4105NRA	50s ribosomal protein l31 type b
HPY11_09770	ENOG4108R96	Methyltransferase, YaeB family
HPY11_09775	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPY11_09795	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPY11_09805	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPY11_09810	ENOG4108Z6B	deaminase
HPY11_09815	ENOG4105CFC	Transporter
HPY11_09845	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY11_09850	ENOG4105CFG	Acts as a chaperone (By similarity)
HPY11_09855	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY11_09860	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPY11_09865	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPY11_09870	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY11_09875	ENOG4105VDB	UPF0125 protein
HPY11_09880	ENOG4108Z1B	Cyclase dehydrase
HPY11_09885	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPY11_09905	ENOG4105DZR	Type I site-specific deoxyribonuclease
HPY11_09920	ENOG4105CVR	type I restriction-modification system
HPY11_09935	ENOG4105DZ0	fad dependent oxidoreductase
HPY11_09940	ENOG4108Z4U	Ferredoxin
HPY11_09980	ENOG4105BZG	amino acid carrier protein
HPY11_09985	ENOG4105EUZ	Beta-lactamase domain protein
HPY11_09990	ENOG41064T2	transcriptional regulator, lysR family
HPY11_10000	ENOG4105E0A	ABC, transporter
HPY11_10005	ENOG4105TVJ	transport system, permease
HPY11_10010	ENOG4105DQ5	transport system permease protein
HPY11_10015	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HPY11_10025	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HPY11_10030	ENOG4105E4F	Isochorismate synthase
HPY11_10035	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY11_10040	ENOG4105WQI	isochorismatase
HPY11_10045	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HPY11_10055	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HPY11_10160	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPY11_10165	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY11_10170	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPY11_10185	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPY11_10190	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY11_10195	ENOG4105N21	Membrane
HPY11_10200	ENOG4105CUT	histidyl-tRNA synthetase
HPY11_10205	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPY11_10220	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HPY11_10225	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY11_10230	ENOG4105WVQ	Fe-S assembly protein IscX
HPY11_10235	ENOG4108ZIT	Ferredoxin, 2FE-2S
HPY11_10250	ENOG4108Z4V	iron-sulfur cluster assembly
HPY11_10255	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HPY11_10260	ENOG4105C3J	Cysteine desulfurase
HPY11_10265	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HPY11_10270	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HPY11_10275	ENOG4105ECY	inositol monophosphatase
HPY11_10280	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY11_10285	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY11_10290	ENOG4105VIE	preprotein translocase, subunit YajC
HPY11_10300	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HPY11_10305	ENOG4105W87	Cbs domain
HPY11_10310	ENOG4108I9X	Isocitrate lyase
HPY11_10315	ENOG4107QP3	malate synthase g
HPY11_10320	ENOG4105C5Q	Transcriptional regulator
HPY11_10325	ENOG4105D3R	alkyl hydroperoxide reductase
HPY11_10330	ENOG4106N3A	copper homeostasis protein cutc
HPY11_10335	ENOG4105CSR	polyphosphate kinase 2
HPY11_10345	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY11_10350	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY11_10355	ENOG4105C8U	phosphate abc transporter
HPY11_10360	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HPY11_10365	ENOG4105C9X	ppx gppa phosphatase
HPY11_10370	ENOG4105DJH	phosphate
HPY11_10375	ENOG4105BZU	Histidine kinase
HPY11_10380	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY11_10390	ENOG4105CFP	Peptidase U32
HPY11_10395	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HPY11_10440	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY11_10445	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPY11_10450	ENOG4105C34	Pseudouridine synthase
HPY11_10455	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_10460	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HPY11_10470	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
HPY11_10475	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY11_10485	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
HPY11_10490	ENOG4107SC1	transglycosylase
HPY11_10495	ENOG4105C5H	ABC transporter
HPY11_10510	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY11_10515	ENOG4108HRK	Histidine kinase
HPY11_10520	ENOG4108NEV	two component transcriptional regulator, LytTR family
HPY11_10530	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HPY11_10535	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY11_10555	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPY11_10560	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HPY11_10565	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HPY11_10575	ENOG4105DTN	riboflavin biosynthesis protein ribF
HPY11_10580	ENOG4105CJR	Integral membrane protein (MviN
HPY11_10585	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HPY11_10590	ENOG41080HT	Transcriptional regulator, arsr family
HPY11_10595	ENOG41063Z6	transcriptional regulator, lysR family
HPY11_10610	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPY11_10615	ENOG4105HF0	Membrane
HPY11_10620	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HPY11_10625	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPY11_10635	ENOG4105CPC	Aldo Keto reductase
HPY11_10645	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_10650	ENOG4105CRK	lysyL-tRNA synthetase
HPY11_10660	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPY11_10670	ENOG4105C1J	atp-dependent rna helicase
HPY11_10680	ENOG4105BZU	Histidine kinase
HPY11_10695	ENOG4108YYD	acetyltransferase
HPY11_10705	ENOG4105BZU	Histidine kinase
HPY11_10730	ENOG4105VNT	transposase (IS4 family) protein
HPY11_10745	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HPY11_10755	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HPY11_10760	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPY11_10765	ENOG4105CHV	Transcription elongation factor NusA
HPY11_10770	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HPY11_10785	ENOG4105NTZ	Preprotein translocase subunit SecG
HPY11_10795	ENOG4105EEI	dihydropteroate synthase
HPY11_10800	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPY11_10805	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HPY11_10810	ENOG4105HBR	Rna-binding protein
HPY11_10815	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPY11_10820	ENOG4105FCK	Membrane
HPY11_10825	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HPY11_10830	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY11_10835	ENOG4105DR5	peptidase
HPY11_10850	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HPY11_10860	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPY11_10865	ENOG4105IPI	Membrane
HPY11_10870	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY11_10875	ENOG4105BZU	Histidine kinase
HPY11_10880	ENOG4107QRA	Extracellular solute-binding protein, family 5
HPY11_10890	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY11_10895	ENOG4105C3U	ABC transporter
HPY11_10900	ENOG4108JQ7	(ABC) transporter
HPY11_10910	ENOG4105RD7	BadF BadG BcrA BcrD
HPY11_10915	ENOG4105E2D	ec 3.2.1.52
HPY11_10920	ENOG4105E2V	Glycosyltransferase 36
HPY11_10930	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY11_10955	ENOG4105XTV	UPF0231 protein
HPY11_10960	ENOG4107QIJ	Aconitate hydratase 2
HPY11_10965	ENOG4105D78	K07001 NTE family protein
HPY11_10970	ENOG4105BZ4	penicillin-binding protein
HPY11_10975	ENOG4105CQ7	ATP-dependent helicase
HPY11_10985	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HPY11_10990	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPY11_10995	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HPY11_11000	ENOG4105DJ0	Poly(A) Polymerase
HPY11_11005	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY11_11010	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPY11_11015	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPY11_11020	ENOG4105E3A	(ABC) transporter
HPY11_11025	ENOG4105DA5	(ABC) transporter
HPY11_11030	ENOG4105CHH	sulfate transporter
HPY11_11035	ENOG41077A9	carbonic anhydrase
HPY11_11040	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPY11_11045	ENOG410630P	Transcriptional regulator
HPY11_11050	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HPY11_11055	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HPY11_11060	ENOG41082RQ	UPF0102 protein
HPY11_11065	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY11_11070	ENOG4105W4M	Transport-associated protein
HPY11_11075	ENOG4105KB2	stringent starvation protein b
HPY11_11080	ENOG4107MKT	Stringent starvation protein a
HPY11_11085	ENOG4105EIX	cytochrome c1
HPY11_11090	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY11_11095	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY11_11100	ENOG4108UJD	30S ribosomal protein S9
HPY11_11105	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPY11_11110	ENOG4105D6Z	AFG1 family ATPase
HPY11_11120	ENOG4105C0H	protease
HPY11_11125	ENOG4105C0H	protease
HPY11_11130	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HPY11_11135	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPY11_11140	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPY11_11145	ENOG4105K5M	30s ribosomal protein S16
HPY11_11150	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY11_11155	ENOG4106KVJ	cytochrome C assembly protein
HPY11_11160	ENOG4108JU6	CBS domain protein
HPY11_11165	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPY11_11170	ENOG4105D9M	gamma-glutamylcysteine synthetase
HPY11_11180	ENOG4105W39	Membrane
HPY11_11190	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY11_11195	ENOG4107QSA	Oxaloacetate decarboxylase
HPY11_11245	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HPY11_11250	ENOG4105CFH	Aspartokinase
HPY11_11255	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPY11_11260	ENOG4105Y3E	Modulates RecA activity (By similarity)
HPY11_11265	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPY11_11275	ENOG4108IJ6	ABC transporter
HPY11_11280	ENOG4105ECW	sulfate abc transporter
HPY11_11285	ENOG4108I5D	sulfate abc transporter
HPY11_11290	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY11_11295	ENOG4105C6T	cysteine synthase
HPY11_11300	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HPY11_11305	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY11_11310	ENOG4108K5P	(LipO)protein
HPY11_11315	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HPY11_11320	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HPY11_11325	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HPY11_11330	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPY11_11335	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPY11_11345	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPY11_11350	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY11_11355	ENOG4107ZVW	dihydroneopterin aldolase
HPY11_11360	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HPY11_11370	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY11_11375	ENOG4105VCC	30S ribosomal protein S21
HPY11_11380	ENOG4105KTH	gatB Yqey
HPY11_11385	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPY11_11390	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY11_11405	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY11_11410	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HPY11_11415	ENOG410804X	Transcriptional regulator
HPY11_11420	ENOG4105CA9	Pyruvate kinase
HPY11_11425	ENOG4105MPN	Membrane
HPY11_11435	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HPY11_11440	ENOG4105D64	Mechanosensitive ion channel
HPY11_11445	ENOG4105D2N	Aldolase
HPY11_11450	ENOG4105BZA	Phosphoglycerate kinase
HPY11_11455	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY11_11460	ENOG4105D05	Receptor
HPY11_11465	ENOG4108R4R	Iron-regulated virulence regulatory protein
HPY11_11470	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY11_11475	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HPY11_11485	ENOG4105RWS	endonuclease I
HPY11_11490	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HPY11_11495	ENOG4105D7Z	glutathione synthase
HPY11_11500	ENOG4108UJU	UPF0301 protein
HPY11_11505	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPY11_11510	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY11_11520	ENOG4105CZX	twitching motility protein
HPY11_11525	ENOG4105CZX	twitching motility protein
HPY11_11530	ENOG4105DFA	alanine racemase domain protein
HPY11_11535	ENOG4105II7	pyrroline-5-carboxylate reductase
HPY11_11540	ENOG4108VIA	integral membrane protein
HPY11_11555	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HPY11_11560	ENOG4105CSA	Coproporphyrinogen iii oxidase
HPY11_11565	ENOG4105CSV	Glutaminase
HPY11_11570	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HPY11_11575	ENOG4105CEN	a g-specific adenine glycosylase
HPY11_11580	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HPY11_11585	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HPY11_11640	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HPY11_11645	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HPY11_11650	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HPY11_11655	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HPY11_11660	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HPY11_11665	ENOG4105NWN	ApaG protein
HPY11_11670	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HPY11_11680	ENOG4107XM3	UPF0442 protein
HPY11_11685	ENOG4105DWK	Membrane
HPY11_11690	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY11_11695	ENOG4105K46	50S ribosomal protein l27
HPY11_11700	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPY11_11705	ENOG4105EAH	synthase
HPY11_11710	ENOG4105D5Q	Arginine ornithine antiporter
HPY11_11715	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HPY11_11720	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPY11_11725	ENOG4105H1G	trap transporter solute receptor taxi family
HPY11_11735	ENOG41081QV	Universal stress protein
HPY11_11755	ENOG4105CEU	Arginine dihydrolase
HPY11_11760	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HPY11_11770	ENOG4105QD6	exported protein
HPY11_11775	ENOG4105C03	ribonuclease
HPY11_11780	ENOG4108Z03	MAF-like protein
HPY11_11785	ENOG4105VQ7	Rod shape-determining protein MreD
HPY11_11790	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HPY11_11830	ENOG4105X0D	Fimbrial protein
HPY11_11840	ENOG4105D7Q	type ii secretion system
HPY11_11845	ENOG4107QHF	type ii secretion system protein e
HPY11_11860	ENOG4105E4G	Type IV pilus
HPY11_11910	ENOG4105C5R	Aminotransferase
HPY11_11915	ENOG4105CFH	Aspartokinase
HPY11_11920	ENOG4105C3R	Methionine synthase
HPY11_11925	ENOG4105EEQ	Na H antiporter
HPY11_11995	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPY11_12005	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HPY11_12025	ENOG4105P4Z	Phage shock protein G
HPY11_12030	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY11_12035	ENOG4105MYN	Zinc uptake regulation protein
HPY11_12050	ENOG4107QP8	phosphohexose isomerase
HPY11_12055	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HPY11_12060	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY11_12065	ENOG4105CDU	Replicative dna helicase
HPY11_12075	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPY11_12080	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPY11_12085	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HPY11_12090	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPY11_12095	ENOG4108UQY	Iron-storage protein
HPY11_12100	ENOG4105W53	bacterioferritin-associated ferredoxin
HPY11_12105	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY11_12110	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY11_12115	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPY11_12130	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPY11_12135	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HPY11_12140	ENOG4105WWK	YheO domain protein
HPY11_12145	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY11_12155	ENOG41069P5	Protein slyX homolog
HPY11_12165	ENOG4105EPW	hflc protein
HPY11_12170	ENOG4107QJR	hflk protein
HPY11_12175	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPY11_12180	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HPY11_12185	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPY11_12190	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HPY11_12195	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HPY11_12200	ENOG4105K8N	protein family UPF0079, ATPase
HPY11_12205	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HPY11_12255	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPY11_12260	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPY11_12265	ENOG4105DJ4	phosphatidylserine decarboxylase
HPY11_12270	ENOG4105C8P	)-transporter
HPY11_12280	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPY11_12285	ENOG41063SB	peptidase
HPY11_12295	ENOG41062JF	Transcriptional regulator
HPY11_12300	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HPY11_12305	ENOG4105E09	nadh pyrophosphatase
HPY11_12310	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HPY11_12315	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY11_12320	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY11_12325	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HPY11_12330	ENOG4108VZM	50s ribosomal protein L10
HPY11_12340	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HPY11_12345	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPY11_12350	ENOG4105PM1	preprotein translocase subunit SecE
HPY11_12355	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY11_12380	ENOG4105CS9	pantothenic acid kinase
HPY11_12385	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPY11_12390	ENOG4105D4A	Cell wall formation (By similarity)
HPY11_12400	ENOG4105JIM	Phosphatidylserine synthase
HPY11_12435	ENOG4107QK7	reductase
HPY11_12445	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HPY11_12455	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HPY11_12465	ENOG4105C1J	atp-dependent rna helicase
HPY11_12470	ENOG4105C9X	ppx gppa phosphatase
HPY11_12475	ENOG4105BZU	Histidine kinase
HPY11_12480	ENOG4105D8G	Major Facilitator superfamily
HPY11_12495	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY11_12500	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HPY11_12505	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HPY11_12510	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HPY11_12515	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY11_12520	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY11_12525	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HPY11_12530	ENOG4107R3N	Filamentation induced by cAMP protein fic
HPY11_12535	ENOG4105DIQ	Transcriptional regulator
HPY11_12545	ENOG4105C01	Dihydroxy-acid dehydratase
HPY11_12550	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPY11_12555	ENOG4105C6Z	Gluconate
HPY11_12560	ENOG4108UHU	Aldolase
HPY11_12565	ENOG4105E0K	tonB-dependent siderophore receptor
HPY11_12580	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_12585	ENOG4105CXN	decarboxylase
HPY11_12590	ENOG4105D5Q	Arginine ornithine antiporter
HPY11_12595	ENOG4108M3R	transcriptional activator CadC
HPY11_12600	ENOG4105W1Y	Transcriptional regulator
HPY11_12615	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPY11_12625	ENOG4105K70	DNA-binding protein
HPY11_12635	ENOG4105R2J	Conserved Protein
HPY11_12640	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HPY11_12645	ENOG4108RG0	uracil-dna glycosylase
HPY11_12650	ENOG4105CUY	Mechanosensitive ion channel
HPY11_12655	ENOG4105CY0	Metallo-Beta-Lactamase
HPY11_12665	ENOG4105ESV	Glycosyl transferase, family 4
HPY11_12685	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY11_12705	ENOG4108SHN	Glycosyl transferase, family 2
HPY11_12715	ENOG4105D75	Capsular exopolysaccharide family
HPY11_12725	ENOG4105DAY	polysaccharide export protein
HPY11_12735	ENOG4108MDC	(LipO)protein
HPY11_12745	ENOG4105E3R	(LipO)protein
HPY11_12755	ENOG4105D3Q	Sugar transferase
HPY11_12775	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY11_12795	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPY11_12800	ENOG4105EY8	ABC transporter
HPY11_12810	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HPY11_12820	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HPY11_12825	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HPY11_12830	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HPY11_12845	ENOG4107T94	Endo-14-beta-xylanase
HPY11_12850	ENOG4105XA0	heptosyltransferase ii
HPY11_12855	ENOG4108ST3	glycosyltransferase
HPY11_12860	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HPY11_12865	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY11_12870	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HPY11_12885	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
HPY11_12890	ENOG4105DKP	glycosyl transferase, family 9
HPY11_12895	ENOG4106WTF	Glycosyl transferase, family 2
HPY11_12900	ENOG4105M5K	heptosyltransferase
HPY11_12905	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPY11_12910	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPY11_12920	ENOG4105W0E	50S ribosomal protein L33
HPY11_12925	ENOG4105KDC	50s ribosomal protein l28
HPY11_12930	ENOG4105W5Q	DNA repair protein (RadC
HPY11_12935	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_12940	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HPY11_12950	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HPY11_12955	ENOG4105D1S	lipid A biosynthesis
HPY11_12960	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HPY11_12965	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPY11_12970	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPY11_12975	ENOG4105DSJ	YicC domain protein
HPY11_13030	ENOG4105DVF	Cytosine-specific methyltransferase
HPY11_13080	ENOG4108TEB	UPF0114 protein
HPY11_13085	ENOG4105VNT	transposase (IS4 family) protein
HPY11_13090	ENOG4105FCK	Membrane
HPY11_13095	ENOG4105C5Y	PTS System
HPY11_13100	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY11_13105	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HPY11_13115	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPY11_13120	ENOG4105FR1	rard protein
HPY11_13125	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY11_13130	ENOG4108DMH	HTH_ARAC
HPY11_13135	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY11_13140	ENOG4105C4R	Atp-dependent dna helicase
HPY11_13145	ENOG4105DGW	oligopeptidase A
HPY11_13150	ENOG4105D6S	protein involved in catabolism of external DNA
HPY11_13155	ENOG4105DC8	reductase
HPY11_13165	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY11_13170	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY11_13175	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPY11_13215	ENOG4105MPD	Cytochrome
HPY11_13300	ENOG4105C4R	Atp-dependent dna helicase
HPY11_13305	ENOG4105Y7M	Transcriptional regulator, TetR family
HPY11_13310	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPY11_13315	ENOG4105BZS	acriflavin resistance protein
HPY11_13320	ENOG4105W0Z	cytoplasmic protein
HPY11_13325	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HPY11_13330	ENOG4105EMY	transcriptional regulator
HPY11_13395	ENOG4108RR8	protoporphyrinogen oxidase
HPY11_13400	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY11_13405	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPY11_13410	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY11_13415	ENOG4105CHU	acetyl-coa acetyltransferase
HPY11_13420	ENOG4105F52	Transcriptional regulator
HPY11_13425	ENOG4105CZQ	inner membrane transport protein YdhC
HPY11_13435	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPY11_13440	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPY11_13445	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPY11_13450	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPY11_13455	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY11_13460	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY11_13470	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPY11_13475	ENOG410684E	atp synthase
HPY11_13480	ENOG4105FA0	parb-like partition protein
HPY11_13485	ENOG4107QJE	Chromosome Partitioning Protein
HPY11_13490	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPY11_13495	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HPY11_13500	ENOG4105QTB	Flavodoxin
HPY11_13595	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY11_13600	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HPY11_13605	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPY11_13615	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HPY11_13630	ENOG4105E5Q	amino acid AbC transporter
HPY11_13635	ENOG4105EAB	amino acid AbC transporter
HPY11_13640	ENOG4106RMF	ParB family
HPY11_13670	ENOG4105CDY	transcriptional regulatory protein
HPY11_13675	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPY11_13680	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_13685	ENOG4108YYI	Protein of unknown function (DUF2810)
HPY11_13690	ENOG41061ZR	Transcriptional regulator
HPY11_13695	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HPY11_13700	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HPY11_13705	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPY11_13710	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY11_13715	ENOG4105CS6	Rhs element vgr protein
HPY11_13740	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY11_13750	ENOG4105C8P	)-transporter
HPY11_13755	ENOG4108Q67	UPF0319 protein
HPY11_13785	ENOG4105EYK	Phosphatidylglycerophosphatase B
HPY11_13795	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HPY11_13820	ENOG4105D6U	Sodium Glutamate Symporter
HPY11_13825	ENOG4105YE1	PilZ domain
HPY11_13840	ENOG4105EFX	secretion protein, HlyD family
HPY11_13845	ENOG4105KK7	inner membrane protein YiaW
HPY11_13850	ENOG4106TD9	Diguanylate cyclase
HPY11_13865	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY11_13870	ENOG4107SEY	Conserved Protein
HPY11_13880	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY11_13885	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HPY11_13895	ENOG4105C1J	atp-dependent rna helicase
HPY11_13900	ENOG4105CUG	Oligopeptidase b
HPY11_13930	ENOG4105CVA	phosphate
HPY11_13935	ENOG4105C8U	phosphate abc transporter
HPY11_13940	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY11_13945	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY11_13960	ENOG4105DWD	nucleoside recognition domain protein
HPY11_13965	ENOG4105CHH	sulfate transporter
HPY11_13975	ENOG4105DR5	peptidase
HPY11_13980	ENOG4105BZU	Histidine kinase
HPY11_13985	ENOG4105EQ2	LysR family Transcriptional regulator
HPY11_13990	ENOG4105E5M	Multidrug resistance protein D
HPY11_13995	ENOG4108Z4X	TRANSCRIPTIONal
HPY11_14010	ENOG4105CK2	sodium dicarboxylate symporter
HPY11_14055	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HPY11_14060	ENOG4105D9R	oxidoreductase
HPY11_14070	ENOG4105BZU	Histidine kinase
HPY11_14075	ENOG4107VXZ	Hydrolase
HPY11_14085	ENOG4105D3G	Pseudouridine synthase
HPY11_14145	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY11_14150	ENOG4108JUB	Transcriptional regulator
HPY11_14190	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HPY11_14195	ENOG4105C2J	ABC transporter
HPY11_14200	ENOG4105CNN	ABC, transporter
HPY11_14205	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPY11_14210	ENOG4108RVA	ribokinase
HPY11_14215	ENOG4105ETE	Transcriptional regulator (LacI family
HPY11_14220	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HPY11_14225	ENOG4108I5U	Uridine phosphorylase
HPY11_14235	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPY11_14240	ENOG4105CXY	transporter
HPY11_14255	ENOG4105CQZ	Histidine kinase
HPY11_14260	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY11_14275	ENOG4105D5U	fad dependent oxidoreductase
HPY11_14285	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPY11_14290	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY11_14295	ENOG4105KJM	monovalent cation h antiporter subunit g
HPY11_14300	ENOG41080TA	Multiple resistance and ph regulation protein f
HPY11_14305	ENOG4105SC1	monovalent cation H antiporter subunit E
HPY11_14310	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HPY11_14315	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HPY11_14320	ENOG4105D65	subunit l
HPY11_14330	ENOG4105Q9Y	Universal stress protein
HPY11_14335	ENOG4105CIC	tryptophan-specific transport protein
HPY11_14350	ENOG4105VRT	cytoplasmic protein
HPY11_14360	ENOG4105BZU	Histidine kinase
HPY11_14365	ENOG4105VEQ	Cold shock protein
HPY11_14400	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPY11_14405	ENOG41069D7	Methyl-accepting chemotaxis
HPY11_14420	ENOG4105D9N	nucleoside
HPY11_14425	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY11_14435	ENOG4108JUA	Transcriptional regulator
HPY11_14440	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY11_14445	ENOG4105VEQ	Cold shock protein
HPY11_14465	ENOG4108UNF	response regulator
HPY11_14475	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HPY11_14480	ENOG4105C5I	Dehydrogenase
HPY11_14500	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY11_14525	ENOG4105C1J	atp-dependent rna helicase
HPY11_14530	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY11_14535	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HPY11_14540	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HPY11_14545	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY11_14550	ENOG4105BZU	Histidine kinase
HPY11_14560	ENOG4107S6Z	Na H antiporter
HPY11_14565	ENOG4105E5M	Multidrug resistance protein D
HPY11_14575	ENOG4105BZU	Histidine kinase
HPY11_14580	ENOG4105KUU	lipolytic protein G-D-S-L family
HPY11_14585	ENOG4106M3D	hemolysin
HPY11_14595	ENOG4107IFA	Lipase (EC 3.1.1.3)
HPY11_14625	ENOG4105DHS	permease protein
HPY11_14630	ENOG4105CM4	permease protein
HPY11_14635	ENOG4108IPW	abc transporter atp-binding protein
HPY11_14655	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY11_14670	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY11_14680	ENOG4105EHG	Permease protein
HPY11_14690	ENOG4105CR8	Transcriptional regulator
HPY11_14705	ENOG4105ETX	regulatoR
HPY11_14715	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HPY11_14725	ENOG410667J	hydrolase
HPY11_14780	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY11_14825	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_14835	ENOG4105DZ1	carboxypeptidase
HPY11_14855	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY11_14860	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HPY11_14865	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY11_14875	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HPY11_14885	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPY11_14890	ENOG41082NX	50s ribosomal protein l35
HPY11_14895	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPY11_14970	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY11_15295	ENOG4105CYM	Glutathione S-transferase
HPY11_15360	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY11_15365	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY11_15415	ENOG4105D9U	N-acetyltransferase
HPY11_15540	ENOG4108MK9	spermidine N(1)-acetyltransferase
HPY11_15705	ENOG4105QNF	Outer membrane lipoprotein
HPY11_15720	ENOG4105YGK	Pfam:UPF0157
HPY11_15795	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY11_15870	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY11_15915	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY11_15945	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HPY11_15960	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HPY11_15995	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HPY11_16145	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HPY11_16170	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY11_16180	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY11_16185	ENOG4105W08	virulence gene repressor rsal
HPY11_16250	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY11_16285	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY11_16315	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HPY11_16340	ENOG4105YGK	Pfam:UPF0157
HPY11_16350	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY11_16380	ENOG4105QNF	Outer membrane lipoprotein
HPY11_16430	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY11_16435	ENOG4105CDV	Ompa motb domain protein
HPY11_16440	ENOG4108NVR	Methyl-accepting chemotaxis
HPY11_16445	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPY11_16450	ENOG4105D7K	pfkb domain protein
HPY11_16455	ENOG4108HKT	sucrose-6-phosphate hydrolase
HPY11_16460	ENOG4105ETE	Transcriptional regulator (LacI family
HPY11_16465	ENOG4105C5Y	PTS System
HPY11_16545	ENOG4108RCM	Nitroreductase
HPY11_16550	ENOG41067V3	Antibiotic biosynthesis monooxygenase
HPY11_16555	ENOG4105ETT	transcriptional Regulator, LysR family
HPY11_16565	ENOG4105RA2	Membrane
HPY11_16580	ENOG4108M3J	Dehydrogenase
HPY11_16615	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY11_16625	ENOG4107RHR	regulatoR
HPY11_16635	ENOG4105KHC	sulfurtransferase
HPY11_16645	ENOG4105D06	uba thif-type nad fad binding protein
HPY11_16650	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY11_16655	ENOG4105EUJ	GTP cyclohydrolase i
HPY11_16660	ENOG4105E0X	reductase
HPY11_16665	ENOG4105CKU	formyltetrahydrofolate synthetase
HPY11_16670	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HPY11_16675	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HPY11_16685	ENOG4105PAD	Hydrolase
HPY11_16690	ENOG4105NXH	GreA GreB family elongation factor
HPY11_16695	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HPY11_16700	ENOG4108JPW	Aminotransferase
HPY11_16705	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HPY11_16720	ENOG4107RCV	ABC transporter, permease
HPY11_16735	ENOG4105DUX	Transporter
HPY11_16760	ENOG4105E43	Extracellular solute-binding protein, family 5
HPY11_16765	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HPY11_16770	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPY11_16775	ENOG4108JQ5	ABC transporter
HPY11_16780	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY11_16795	ENOG4105CYM	Glutathione S-transferase
HPY11_16815	ENOG4105KA0	thioesterase Superfamily protein
HPY11_16840	ENOG4105CWB	LysR family transcriptional Regulator
HPY11_16845	ENOG4105CD5	CoA-binding domain protein
HPY11_16865	ENOG4108ZJT	translation initiation factor, Sui1
HPY11_16935	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY11_16945	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY11_16950	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY11_16965	ENOG4105BZU	Histidine kinase
HPY11_16975	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY11_16985	ENOG4105BZU	Histidine kinase
HPY11_17020	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HPY11_17025	ENOG4105VNT	transposase (IS4 family) protein
HPY11_17035	ENOG4105DU1	integral membrane protein, terc
HPY11_17040	ENOG4105CGH	5'-nucleotidase
HPY11_17045	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
HPY11_17050	ENOG4108UQ5	membrane protein YcdZ
HPY11_17055	ENOG4105DUM	transcriptional regulator, lysR family
HPY11_17060	ENOG4105TMB	Formate nitrite transporter
HPY11_17070	ENOG4105DS1	cytochrome b561
HPY11_17080	ENOG4105EPM	Diguanylate phosphodiesterase
HPY11_17095	ENOG410607N	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity)
HPY11_17100	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HPY11_17105	ENOG4105C08	Histidine kinase
HPY11_17110	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HPY11_17115	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HPY11_17120	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HPY11_17125	ENOG4105CKI	cobalamin synthesis protein
HPY11_17130	ENOG4105CMQ	Chloride channel
HPY11_17140	ENOG4107KBT	8-Amino-7-oxononanoate synthase
HPY11_17145	ENOG4108MGY	Histidine kinase
HPY11_17150	ENOG4105EYH	Exonuclease
HPY11_17155	ENOG4107RFY	SbcCD D subunit
HPY11_17160	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPY11_17165	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HPY11_17170	ENOG4105DE4	1-phosphofructokinase
HPY11_17175	ENOG4105DM4	PTS System
HPY11_17180	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY11_17185	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY11_17190	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HPY11_17195	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HPY11_17205	ENOG4107VXZ	Hydrolase
HPY11_17210	ENOG4108N3W	hemolysin secretion protein
HPY11_17215	ENOG4105CEE	C4-dicarboxylate transporter
HPY11_17220	ENOG4105EJQ	L-serine dehydratase
HPY11_17225	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY11_17230	ENOG4105BZU	Histidine kinase
HPY11_17245	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY11_17265	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY11_17270	ENOG4108KX4	response regulator
HPY11_17275	ENOG4105BZU	Histidine kinase
HPY11_17280	ENOG4105CXY	transporter
HPY11_17285	ENOG4105C4Y	ABC transporter
HPY11_17290	ENOG4107RCV	ABC transporter, permease
HPY11_17295	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY11_17300	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HPY11_17310	ENOG4105CHU	acetyl-coa acetyltransferase
HPY11_17320	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY11_17325	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY11_17340	ENOG4105BZU	Histidine kinase
HPY11_17345	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY11_17355	ENOG4108I6A	alcohol dehydrogenase
HPY11_17365	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
HPY11_17375	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
HPY11_17380	ENOG4105CXY	transporter
HPY11_17385	ENOG4105CA9	Pyruvate kinase
HPY11_17390	ENOG4105BZU	Histidine kinase
HPY11_17395	ENOG4108SV3	Tmao reductase system periplasmic protein tort
HPY11_17400	ENOG4108Z5K	methylglyoxal synthase
HPY11_17405	ENOG4108RWI	nicotinamidase
HPY11_17410	ENOG41080IJ	Diacylglycerol kinase
HPY11_17415	ENOG41088T4	Helicase IV
HPY11_17420	ENOG4105EM2	membrane
HPY11_17450	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HPY11_17455	ENOG4105E0C	molybdate abc transporter
HPY11_17460	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HPY11_17465	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HPY11_17515	ENOG4105EYM	Major Facilitator superfamily
HPY11_17520	ENOG4105C0W	non-ribosomal peptide synthetase
HPY11_17545	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY11_17550	ENOG4105C94	Transporter
HPY11_17570	ENOG4105BZ1	(ABC) transporter
HPY11_17575	ENOG4105BZ1	(ABC) transporter
HPY11_17585	ENOG4105BZU	Histidine kinase
HPY11_17590	ENOG4108QGH	periplasmic
HPY11_17600	ENOG41082IR	Excinuclease ABC C subunit domain protein
HPY11_17605	ENOG4108YXG	UPF0502 protein
HPY11_17615	ENOG41090HJ	UPF0265 protein
HPY11_17625	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HPY11_17630	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPY11_17635	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HPY11_17640	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HPY11_17645	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPY11_17650	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY11_17655	ENOG4105K63	Thioredoxin
HPY11_17680	ENOG4105DMR	ABC, transporter
HPY11_17685	ENOG4105GBT	ABC transporter
HPY11_17690	ENOG4106PMH	Extracellular solute-binding protein family 3
HPY11_17695	ENOG4105E5Z	arginine transporter ATP-binding subunit
HPY11_17705	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HPY11_17715	ENOG4108YZ4	nudix hydrolase
HPY11_17720	ENOG4105C5W	Aldolase
HPY11_17725	ENOG4106RE7	Cytochrome
HPY11_17730	ENOG4107XI7	Tetr family transcriptional regulator
HPY11_17735	ENOG4105C1J	atp-dependent rna helicase
HPY11_17740	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HPY11_17745	ENOG4105E0U	tyrosine-specific transport protein
HPY11_17750	ENOG4108N3W	hemolysin secretion protein
HPY11_17755	ENOG4105CMR	udp-glucose 4-epimerase
HPY11_17760	ENOG4105E7W	lamb ycsf family protein
HPY11_17770	ENOG4107R7A	Allophanate hydrolase subunit 2
HPY11_17780	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HPY11_17785	ENOG4105CV6	ABC transporter, permease
HPY11_17790	ENOG4108I0Y	(ABC) transporter
HPY11_17800	ENOG4105RKW	reductase (By
HPY11_17815	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY11_17830	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY11_17845	ENOG4107RE1	Inosine-guanosine kinase
HPY11_17850	ENOG4105E0M	Sulfatase
HPY11_17860	ENOG4105C1J	atp-dependent rna helicase
HPY11_17875	ENOG4105CVA	phosphate
HPY11_17885	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HPY11_17890	ENOG4108M1A	Chitin-binding protein
HPY11_17895	ENOG4105D4Y	metalloprotease
HPY11_17910	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HPY11_17920	ENOG4105CJW	magnesium transporter
HPY11_17930	ENOG4105CZK	Aspartate kinase
HPY11_17940	ENOG41090A4	Pterin carbinolamine dehydratase
HPY11_17945	ENOG4105MIR	Phenylalanine 4-monooxygenase
HPY11_17950	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY11_17965	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY11_17970	ENOG4105EGI	Transcriptional regulator
HPY11_17990	ENOG4105C37	(CBS) domain
HPY11_17995	ENOG4108UKZ	OsmC family
HPY11_18000	ENOG4107YWA	deoxycytidylate deaminase
HPY11_18020	ENOG4105DVH	amino acid
HPY11_18025	ENOG4106TD9	Diguanylate cyclase
HPY11_18035	ENOG4107RGM	aldo keto reductase
HPY11_18040	ENOG4107T9C	Alpha amylase catalytic region
HPY11_18050	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY11_18055	ENOG4108M0H	Extracellular lipase
HPY11_18060	ENOG4107SDU	Methyl-accepting chemotaxis
HPY11_18065	ENOG4105D4Y	metalloprotease
HPY11_18070	ENOG4105EIF	outer membrane protein W
HPY11_18080	ENOG41061WM	D-Alanyl-D-Alanine
HPY11_18085	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY11_18090	ENOG4105VEQ	Cold shock protein
HPY11_18100	ENOG4105BZC	d-serine deaminase
HPY11_18105	ENOG4105W8I	Transcriptional regulator
HPY11_18155	ENOG4107R08	Integrase
HPY11_18175	ENOG4105CPQ	Dehydrogenase
HPY11_18180	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY11_18185	ENOG4108IQK	o-acetylhomoserine
HPY11_18190	ENOG4105EXG	Transcriptional regulator
HPY11_18195	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HPY11_18220	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY11_18225	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HPY11_18230	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HPY11_18235	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPY11_18260	ENOG4105BZW	Glycerate kinase
HPY11_18265	ENOG4105C6Z	Gluconate
HPY11_18270	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HPY11_18275	ENOG4108NVR	Methyl-accepting chemotaxis
HPY11_18280	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HPY11_18285	ENOG41090JE	Utilization Protein
HPY11_18290	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY11_18295	ENOG4105WQ5	TonB family
HPY11_18300	ENOG41090AP	transport protein
HPY11_18305	ENOG4106GFD	transport protein
HPY11_18310	ENOG4107R4I	Periplasmic binding protein
HPY11_18315	ENOG4105EHG	Permease protein
HPY11_18320	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY11_18350	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_18355	ENOG4105QVC	MOSC domain-containing protein
HPY11_18355	ENOG4105QVC	MOSC domain-containing protein
HPY11_18360	ENOG4105EKE	dihydroorotase
HPY11_18365	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
HPY11_18370	ENOG4105CKW	Inner membrane protein yedI
HPY11_18380	ENOG4108ESY	Metal dependent phosphohydrolase
HPY11_18385	ENOG4105VEQ	Cold shock protein
HPY11_18410	ENOG4105BZU	Histidine kinase
HPY11_18415	ENOG4105E98	transcriptional regulator DeoR family
HPY11_18430	ENOG4105EG2	ABC transporter, permease
HPY11_18435	ENOG4105D56	permease protein
HPY11_18440	ENOG4107FKK	extracellular solute-binding protein family 1
HPY11_18445	ENOG4108IJ9	(ABC) transporter
HPY11_18450	ENOG4108HK0	-acetyltransferase
HPY11_18465	ENOG4105K8R	UPF0145 protein
HPY11_18470	ENOG41086KC	Transcriptional regulator
HPY11_18475	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HPY11_18485	ENOG4105K56	Transcriptional regulator
HPY11_18490	ENOG4106TD9	Diguanylate cyclase
HPY11_18505	ENOG4105BZU	Histidine kinase
HPY11_18525	ENOG4105ETT	transcriptional Regulator, LysR family
HPY11_18530	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY11_18540	ENOG4105EUB	pirin domain protein
HPY11_18545	ENOG4105NBK	UPF0345 protein
HPY11_18555	ENOG4105E5W	Transporter
HPY11_18560	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_18565	ENOG4105DAN	ATP-dependent protease
HPY11_18575	ENOG4108JQ5	ABC transporter
HPY11_18580	ENOG4105E89	ABC transporter
HPY11_18585	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_18595	ENOG4105CC0	LysR family Transcriptional regulator
HPY11_18605	ENOG4105DAA	L-lactate
HPY11_18620	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HPY11_18630	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HPY11_18650	ENOG4108RPX	mosc domain containing protein
HPY11_18655	ENOG4105C1J	atp-dependent rna helicase
HPY11_18660	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HPY11_18665	ENOG4105C6F	GntR Family Transcriptional Regulator
HPY11_18670	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPY11_18675	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
HPY11_18680	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY11_18685	ENOG4105DEI	Mannitol dehydrogenase
HPY11_18695	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
HPY11_18700	ENOG4108UHU	Aldolase
HPY11_18705	ENOG4105P66	Membrane
HPY11_18710	ENOG4105CR8	Transcriptional regulator
HPY11_18720	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY11_18730	ENOG4105BZ1	(ABC) transporter
HPY11_18740	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY11_18750	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY11_18775	ENOG4105K56	Transcriptional regulator
HPY11_18780	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HPY11_18790	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY11_18795	ENOG4105VW4	glutaredoxin 3
HPY11_18800	ENOG4108P2H	Inner membrane protein YjiG
HPY11_18805	ENOG41074DU	domain protein
HPY11_18810	ENOG4105DN9	Na H antiporter
HPY11_18820	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPY11_18825	ENOG4105D03	DNA-3-methyladenine glycosylase II
HPY11_18830	ENOG4108VGI	doxx family
HPY11_18855	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPY11_18865	ENOG4107W52	maltose operon periplasmic protein
HPY11_18870	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPY11_18885	ENOG4108N3W	hemolysin secretion protein
HPY11_18895	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_18900	ENOG4105BZU	Histidine kinase
HPY11_18910	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY11_18915	ENOG4105CDA	abc transporter atp-binding protein
HPY11_18925	ENOG4106TNF	Periplasmic binding protein
HPY11_18930	ENOG4105EZ7	amino acid ABC transporter
HPY11_18935	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HPY11_18940	ENOG4105CTS	PTS system mannitol-specific
HPY11_18945	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HPY11_18950	ENOG4105E61	Mannitol repressor protein
HPY11_18955	ENOG4105EP9	oxidoreductase
HPY11_18985	ENOG4108RYK	Nad-dependent epimerase dehydratase
HPY11_18990	ENOG4105JQN	Transcriptional regulator
HPY11_18995	ENOG41069D7	Methyl-accepting chemotaxis
HPY11_19000	ENOG4105EMU	Dehydrogenase
HPY11_19005	ENOG4105JQN	Transcriptional regulator
HPY11_19025	ENOG4105D5Q	Arginine ornithine antiporter
HPY11_19030	ENOG4105CXN	decarboxylase
HPY11_19040	ENOG4105VJY	transcriptional regulator
HPY11_19070	ENOG4107RGH	Aldehyde dehydrogenase
HPY11_19075	ENOG4105EW9	transcriptional regulator AsnC family
HPY11_19080	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_19090	ENOG4105CK7	Sodium proline symporter
HPY11_19100	ENOG4105C26	Dehydrogenase
HPY11_19115	ENOG4105E6M	Sulphatase-modifying factor protein
HPY11_19130	ENOG4107QZV	Type I secretion membrane fusion protein
HPY11_19145	ENOG4108JJA	ABC, transporter
HPY11_19165	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_19170	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY11_19180	ENOG4105BZU	Histidine kinase
HPY11_19185	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY11_19190	ENOG4108V3W	Chemotaxis protein, CheW
HPY11_19195	ENOG4108V3W	Chemotaxis protein, CheW
HPY11_19200	ENOG4105CBS	Chea signal transduction histidine kinase
HPY11_19205	ENOG4108VYJ	response regulator receiver protein
HPY11_19220	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY11_19225	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY11_19235	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HPY11_19240	ENOG4107RUE	extracellular solute-binding protein family 1