locus-tag	class	description
HPY11_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY11_00010	COG0592	DNA-directed DNA polymerase activity
HPY11_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY11_00020	COG0187	DNA topoisomerase II activity
HPY11_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY11_00035	COG3977	Valine--pyruvate aminotransferase
HPY11_00040	COG0751	glycine-tRNA ligase activity
HPY11_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY11_00050	COG2119	membrane
HPY11_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY11_00070	COG0604	alcohol dehydrogenase
HPY11_00080	COG0129	dihydroxy-acid dehydratase activity
HPY11_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY11_00100	COG0606	chelatase, subunit chli
HPY11_00105	COG0204	Acyl-transferase
HPY11_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY11_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY11_00125	COG3084	Protein conserved in bacteria
HPY11_00130	COG4326	sporulation control protein
HPY11_00135	COG1272	protein, Hemolysin III
HPY11_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY11_00150	COG0569	domain protein
HPY11_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY11_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY11_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY11_00165	COG0242	peptide deformylase activity
HPY11_00170	COG1652	LysM domain
HPY11_00175	COG0758	DNA mediated transformation
HPY11_00180	COG2922	Belongs to the Smg family
HPY11_00185	COG0551	DNA topoisomerase type I activity
HPY11_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY11_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY11_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY11_00205	COG0408	coproporphyrinogen oxidase activity
HPY11_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY11_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY11_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY11_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY11_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY11_00280	COG2104	thiamine diphosphate biosynthetic process
HPY11_00285	COG2022	thiamine diphosphate biosynthetic process
HPY11_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY11_00295	COG0006	proline dipeptidase activity
HPY11_00295	COG0006	proline dipeptidase activity
HPY11_00315	COG1522	sequence-specific DNA binding
HPY11_00320	COG5001	Diguanylate cyclase
HPY11_00320	COG5002	protein histidine kinase activity
HPY11_00340	COG0589	response to stress
HPY11_00345	COG1528	Iron-storage protein
HPY11_00355	COG2081	HI0933 family
HPY11_00365	COG1322	Protein conserved in bacteria
HPY11_00370	COG2226	methyltransferase
HPY11_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY11_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY11_00395	COG0805	protein transport
HPY11_00400	COG0534	Mate efflux family protein
HPY11_00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY11_00415	COG2937	Belongs to the GPAT DAPAT family
HPY11_00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY11_00425	COG3161	chorismate lyase activity
HPY11_00430	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY11_00435	COG0840	transmembrane signaling receptor activity
HPY11_00445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY11_00450	COG0084	hydrolase, TatD family'
HPY11_00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY11_00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY11_00485	COG3078	GTPase activator activity
HPY11_00500	COG3071	HemY protein
HPY11_00505	COG2959	enzyme of heme biosynthesis
HPY11_00510	COG1587	Uroporphyrinogen-III synthase
HPY11_00515	COG0181	hydroxymethylbilane synthase activity
HPY11_00525	COG1965	Belongs to the frataxin family
HPY11_00535	COG0019	diaminopimelate decarboxylase activity
HPY11_00540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY11_00550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY11_00555	COG1011	Hydrolase
HPY11_00560	COG2200	EAL domain
HPY11_00560	COG3287	FIST C domain
HPY11_00560	COG2199	diguanylate cyclase activity
HPY11_00575	COG0561	phosphatase activity
HPY11_00580	COG2267	carboxylic ester hydrolase activity
HPY11_00585	COG1280	lysine exporter protein (LysE YggA)
HPY11_00590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY11_00595	COG0783	Belongs to the Dps family
HPY11_00625	COG0742	ribosomal rna small subunit methyltransferase
HPY11_00630	COG0552	protein localization to endoplasmic reticulum
HPY11_00635	COG2884	Cell division ATP-binding protein ftsE
HPY11_00640	COG2177	Part of the ABC transporter FtsEX involved in
HPY11_00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY11_00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_00740	COG2003	Belongs to the UPF0758 family
HPY11_00775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY11_00785	COG1404	Belongs to the peptidase S8 family
HPY11_00790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY11_00855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY11_00860	COG3300	MHYT domain
HPY11_00860	COG5001	Diguanylate cyclase
HPY11_00870	COG3852	Histidine kinase
HPY11_00880	COG0174	glutamine synthetase
HPY11_00900	COG1295	ribonuclease BN
HPY11_00905	COG1490	D-aminoacyl-tRNA deacylase activity
HPY11_00910	COG0456	acetyltransferase
HPY11_00920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY11_00925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY11_00930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY11_00935	COG3031	protein transport across the cell outer membrane
HPY11_00945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY11_00950	COG1459	type II secretion system
HPY11_00955	COG2165	general secretion pathway protein
HPY11_00960	COG2165	general secretion pathway protein
HPY11_00965	COG2165	general secretion pathway protein
HPY11_00970	COG4795	General secretion pathway protein
HPY11_00975	COG3156	type II secretion system protein K
HPY11_00980	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY11_00985	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY11_00995	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY11_01000	COG0494	nUDIX hydrolase
HPY11_01010	COG1040	competence protein
HPY11_01020	COG0596	Alpha beta hydrolase
HPY11_01030	COG2183	response to ionizing radiation
HPY11_01070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY11_01075	COG2199	diguanylate cyclase activity
HPY11_01080	COG0745	RESPONSE REGULATOR receiver
HPY11_01090	COG2233	PERMEase
HPY11_01095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY11_01100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY11_01105	COG1758	RNA polymerase activity
HPY11_01110	COG0194	GDP metabolic process
HPY11_01115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY11_01120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY11_01140	COG4232	protein-disulfide reductase activity
HPY11_01150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY11_01155	COG1027	Aspartate ammonia-lyase
HPY11_01160	COG3706	GGDEF domain
HPY11_01165	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY11_01170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY11_01180	COG2205	protein histidine kinase activity
HPY11_01185	COG0745	RESPONSE REGULATOR receiver
HPY11_01195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY11_01200	COG0205	6-phosphofructokinase activity
HPY11_01205	COG1494	fructose-1,6-bisphosphatase
HPY11_01210	COG3074	FtsZ-dependent cytokinesis
HPY11_01215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY11_01220	COG0460	homoserine dehydrogenase
HPY11_01220	COG0527	aspartate kinase activity
HPY11_01225	COG0626	cystathionine gamma-synthase activity
HPY11_01230	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY11_01235	COG0281	malic enzyme
HPY11_01240	COG0254	rRNA binding
HPY11_01245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY11_01250	COG1609	Transcriptional regulator
HPY11_01255	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY11_01260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY11_01265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY11_01270	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY11_01275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY11_01280	COG0534	Mate efflux family protein
HPY11_01285	COG0149	triose-phosphate isomerase activity
HPY11_01310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY11_01315	COG0459	protein refolding
HPY11_01325	COG1509	lysine 2,3-aminomutase activity
HPY11_01330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY11_01340	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY11_01345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY11_01350	COG1053	succinate dehydrogenase
HPY11_01355	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY11_01360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY11_01365	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY11_01370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY11_01375	COG1045	serine acetyltransferase
HPY11_01385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY11_01390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY11_01395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY11_01400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY11_01405	COG0137	argininosuccinate synthase activity
HPY11_01410	COG0165	Argininosuccinate lyase
HPY11_01420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_01425	COG0678	peroxiredoxin activity
HPY11_01425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY11_01435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY11_01465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY11_01470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY11_01480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY11_01485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY11_01490	COG0546	phosphoglycolate phosphatase activity
HPY11_01495	COG0180	Tryptophanyl-tRNA synthetase
HPY11_01515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY11_01525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY11_01535	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_01550	COG3954	Phosphoribulokinase
HPY11_01560	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY11_01570	COG0488	(ABC) transporter
HPY11_01575	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY11_01590	COG1047	Peptidyl-prolyl cis-trans
HPY11_01600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY11_01605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY11_01610	COG3083	sulfuric ester hydrolase activity
HPY11_01615	COG0557	exoribonuclease II activity
HPY11_01620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY11_01625	COG0051	transcription antitermination factor activity, RNA binding
HPY11_01630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY11_01635	COG0088	Forms part of the polypeptide exit tunnel
HPY11_01640	COG0089	rRNA binding
HPY11_01645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY11_01650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY11_01655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY11_01660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY11_01665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY11_01670	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY11_01675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY11_01680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY11_01685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY11_01690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY11_01695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY11_01700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY11_01705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY11_01710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY11_01715	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY11_01720	COG1841	ribosomal large subunit assembly
HPY11_01730	COG0201	protein transport
HPY11_01735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY11_01740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY11_01745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY11_01750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY11_01755	COG0202	RNA polymerase activity
HPY11_01760	COG0203	ribosomal protein L17
HPY11_01770	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY11_01775	COG3266	domain, Protein
HPY11_01775	COG3061	Opacity-associated protein A
HPY11_01780	COG0697	spore germination
HPY11_01785	COG2153	protein acetylation
HPY11_01790	COG0513	Belongs to the DEAD box helicase family
HPY11_01800	COG0737	Belongs to the 5'-nucleotidase family
HPY11_01805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY11_01805	COG1648	precorrin-2 dehydrogenase activity
HPY11_01810	COG0175	sulfate reduction
HPY11_01815	COG2895	sulfate adenylyltransferase (ATP) activity
HPY11_01820	COG0529	Catalyzes the synthesis of activated sulfate
HPY11_01840	COG1136	(ABC) transporter
HPY11_01855	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY11_01860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_01865	COG0729	surface antigen
HPY11_01875	COG2105	PFAM AIG2 family protein
HPY11_01880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY11_01890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY11_01895	COG0163	prenyltransferase activity
HPY11_01905	COG1178	ABC-type Fe3 transport system permease component
HPY11_01910	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY11_01915	COG3028	Belongs to the UPF0307 family
HPY11_01920	COG0312	modulator of DNA gyrase
HPY11_01925	COG2239	Acts as a magnesium transporter
HPY11_01930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_01935	COG1660	Displays ATPase and GTPase activities
HPY11_01940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_01945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY11_01955	COG1137	ATPase activity
HPY11_01960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY11_01975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY11_01975	COG0517	IMP dehydrogenase activity
HPY11_01985	COG1127	ABC transporter
HPY11_01990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY11_01995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY11_02000	COG2854	intermembrane phospholipid transfer
HPY11_02010	COG5007	Belongs to the BolA IbaG family
HPY11_02015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY11_02025	COG0251	oxidation-reduction process
HPY11_02035	COG0540	Belongs to the ATCase OTCase family
HPY11_02045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY11_02050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY11_02055	COG0564	pseudouridine synthase activity
HPY11_02060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY11_02065	COG0525	valine-tRNA ligase activity
HPY11_02070	COG2927	DNA polymerase III (CHI subunit)
HPY11_02075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY11_02080	COG0795	lipopolysaccharide-transporting ATPase activity
HPY11_02085	COG0795	lipopolysaccharide-transporting ATPase activity
HPY11_02100	COG3437	response regulator, receiver
HPY11_02140	COG0066	3-isopropylmalate dehydratase activity
HPY11_02145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY11_02150	COG0473	3-isopropylmalate dehydrogenase activity
HPY11_02170	COG0583	DNA-binding transcription factor activity
HPY11_02175	COG1022	Amp-dependent synthetase and ligase
HPY11_02180	COG0028	Belongs to the TPP enzyme family
HPY11_02185	COG0440	acetolactate synthase activity
HPY11_02190	COG3385	transposase activity
HPY11_02195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY11_02200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY11_02205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY11_02215	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY11_02220	COG3079	Belongs to the UPF0149 family
HPY11_02225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_02230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_02245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY11_02255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY11_02260	COG1595	DNA-templated transcription, initiation
HPY11_02275	COG3086	response to oxidative stress
HPY11_02280	COG0481	GTPase activity
HPY11_02290	COG0571	ribonuclease III activity
HPY11_02295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY11_02300	COG1381	Involved in DNA repair and RecF pathway recombination
HPY11_02305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY11_02340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY11_02345	COG3956	TIGRFAM MazG family protein
HPY11_02350	COG0504	CTP synthase activity
HPY11_02355	COG0148	phosphopyruvate hydratase activity
HPY11_02365	COG3267	Type II secretory pathway component ExeA
HPY11_02365	COG3409	Peptidoglycan-binding domain 1 protein
HPY11_02375	COG4991	sh3 domain protein
HPY11_02380	COG0306	phosphate transporter
HPY11_02385	COG1392	Phosphate transport regulator
HPY11_02390	COG3025	triphosphatase activity
HPY11_02395	COG0840	transmembrane signaling receptor activity
HPY11_02400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY11_02405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY11_02405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY11_02410	COG1538	Outer membrane efflux protein
HPY11_02415	COG0494	nUDIX hydrolase
HPY11_02420	COG3151	Protein conserved in bacteria
HPY11_02430	COG3150	esterase
HPY11_02435	COG0187	DNA topoisomerase II activity
HPY11_02440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY11_02450	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY11_02455	COG0237	dephospho-CoA kinase activity
HPY11_02465	COG1459	type II secretion system
HPY11_02470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY11_02490	COG0716	FMN binding
HPY11_02495	COG4974	Belongs to the 'phage' integrase family
HPY11_02500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY11_02505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY11_02510	COG2186	Transcriptional regulator
HPY11_02515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY11_02520	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY11_02525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_02540	COG3116	cell division
HPY11_02545	COG0768	penicillin binding
HPY11_02550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY11_02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY11_02565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY11_02570	COG0772	Belongs to the SEDS family
HPY11_02575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY11_02580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY11_02585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY11_02590	COG0849	cell division
HPY11_02595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY11_02600	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY11_02610	COG0653	protein targeting
HPY11_02615	COG0494	nUDIX hydrolase
HPY11_02620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY11_02630	COG0505	Belongs to the CarA family
HPY11_02635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY11_02650	COG0730	response to heat
HPY11_02655	COG0583	DNA-binding transcription factor activity
HPY11_02660	COG2860	membrane
HPY11_02665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY11_02675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY11_02685	COG0493	'glutamate synthase
HPY11_02690	COG0070	glutamate synthase
HPY11_02690	COG0067	glutamate synthase
HPY11_02690	COG0069	glutamate synthase activity
HPY11_02700	COG0070	glutamate synthase
HPY11_02700	COG0069	glutamate synthase activity
HPY11_02700	COG0067	glutamate synthase
HPY11_02705	COG1242	4 iron, 4 sulfur cluster binding
HPY11_02710	COG3706	GGDEF domain
HPY11_02710	COG4251	negative regulation of phosphorylation
HPY11_02710	COG5001	Diguanylate cyclase
HPY11_02710	COG2203	Gaf domain
HPY11_02715	COG0784	Response regulator, receiver
HPY11_02715	COG2198	Histidine kinase
HPY11_02715	COG5002	protein histidine kinase activity
HPY11_02720	COG0745	RESPONSE REGULATOR receiver
HPY11_02730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY11_02750	COG0083	homoserine kinase activity
HPY11_02755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY11_02760	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY11_02765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY11_02770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY11_02785	COG1115	amino acid carrier protein
HPY11_02790	COG3022	response to hydroperoxide
HPY11_02800	COG0084	hydrolase, TatD family'
HPY11_02805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY11_02815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY11_02820	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY11_02825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY11_02830	COG0813	purine-nucleoside phosphorylase activity
HPY11_02840	COG0560	Phosphoserine phosphatase
HPY11_02850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY11_02855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY11_02860	COG1022	Amp-dependent synthetase and ligase
HPY11_02875	COG3250	beta-galactosidase activity
HPY11_02885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_02900	COG0569	domain protein
HPY11_02900	COG0189	ligase activity
HPY11_02905	COG0456	acetyltransferase
HPY11_02915	COG2171	N-acyltransferase activity
HPY11_02920	COG3141	response to X-ray
HPY11_02935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY11_02940	COG1074	ATP-dependent DNA helicase activity
HPY11_02945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY11_02955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY11_02955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY11_02965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY11_02970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY11_02975	COG2166	iron-sulfur cluster assembly
HPY11_02980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY11_02985	COG0693	protein deglycase activity
HPY11_02990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY11_02995	COG3248	Nucleoside-binding outer membrane protein
HPY11_03005	COG1595	DNA-templated transcription, initiation
HPY11_03015	COG2211	Major facilitator Superfamily
HPY11_03030	COG2813	Specifically methylates the guanine in position
HPY11_03035	COG0271	Belongs to the BolA IbaG family
HPY11_03045	COG1805	sodium ion transport
HPY11_03050	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY11_03055	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY11_03060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY11_03065	COG2871	sodium ion transport
HPY11_03070	COG1477	protein flavinylation
HPY11_03090	COG3706	GGDEF domain
HPY11_03095	COG0733	neurotransmitter:sodium symporter activity
HPY11_03105	COG0189	ligase activity
HPY11_03110	COG4067	protein conserved in archaea
HPY11_03110	COG0189	ligase activity
HPY11_03115	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY11_03120	COG2252	PERMEase
HPY11_03125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY11_03140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY11_03145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY11_03150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY11_03155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_03155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_03170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY11_03175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY11_03180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY11_03185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY11_03195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY11_03200	COG0024	Methionine aminopeptidase
HPY11_03205	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY11_03210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY11_03215	COG0528	UMP kinase activity
HPY11_03220	COG0233	cytoplasmic translational termination
HPY11_03225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY11_03230	COG0575	Belongs to the CDS family
HPY11_03235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY11_03240	COG0750	zinc metalloprotease
HPY11_03250	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY11_03255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_03260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY11_03265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_03270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_03275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY11_03280	COG0587	DNA-directed DNA polymerase activity
HPY11_03285	COG0825	malonyl-CoA metabolic process
HPY11_03290	COG0037	tRNA processing
HPY11_03300	COG3479	Phenolic acid decarboxylase
HPY11_03305	COG0347	Belongs to the P(II) protein family
HPY11_03310	COG3021	interspecies interaction between organisms
HPY11_03315	COG1388	LysM domain
HPY11_03315	COG0741	lytic transglycosylase activity
HPY11_03320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY11_03325	COG2226	methyltransferase
HPY11_03330	COG0328	RNA-DNA hybrid ribonuclease activity
HPY11_03345	COG1960	acyl-CoA dehydrogenase activity
HPY11_03350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY11_03355	COG0121	glutamine amidotransferase
HPY11_03360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY11_03365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY11_03370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY11_03375	COG3706	GGDEF domain
HPY11_03380	COG1187	pseudouridine synthase activity
HPY11_03385	COG2840	Smr protein MutS2
HPY11_03400	COG3735	TraB family
HPY11_03415	COG2608	mercury ion transmembrane transporter activity
HPY11_03415	COG2217	Heavy metal translocating P-type atpase
HPY11_03420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY11_03435	COG1629	transport
HPY11_03435	COG4774	siderophore transport
HPY11_03440	COG2375	cellular response to nickel ion
HPY11_03445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY11_03445	COG3433	isochorismatase activity
HPY11_03445	COG2226	methyltransferase
HPY11_03480	COG0784	Response regulator, receiver
HPY11_03480	COG0835	chemotaxis
HPY11_03485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY11_03490	COG1815	bacterial-type flagellum-dependent cell motility
HPY11_03505	COG1749	Flagellar hook protein flgE
HPY11_03510	COG4787	bacterial-type flagellum-dependent cell motility
HPY11_03520	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY11_03525	COG1706	bacterial-type flagellum-dependent cell motility
HPY11_03530	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY11_03530	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY11_03545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_03550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_03635	COG0012	GTP binding
HPY11_03640	COG0193	aminoacyl-tRNA hydrolase activity
HPY11_03645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY11_03650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY11_03655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY11_03660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY11_03665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY11_03670	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY11_03680	COG2912	Transglutaminase-like superfamily
HPY11_03685	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY11_03690	COG0737	Belongs to the 5'-nucleotidase family
HPY11_03695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY11_03700	COG2233	PERMEase
HPY11_03720	COG1393	Belongs to the ArsC family
HPY11_03725	COG4783	chaperone-mediated protein folding
HPY11_03745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY11_03760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY11_03770	COG1876	peptidase activity
HPY11_03780	COG1393	Belongs to the ArsC family
HPY11_03800	COG2837	iron assimilation
HPY11_03805	COG2706	6-phosphogluconolactonase activity
HPY11_03815	COG0800	Aldolase
HPY11_03825	COG4145	pantothenate transmembrane transporter activity
HPY11_03835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPY11_03845	COG0837	glucose binding
HPY11_03845	COG1737	Transcriptional regulator
HPY11_03850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_03855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_03860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_03865	COG1334	flagellar protein FlaG
HPY11_03870	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY11_03880	COG1516	flagellar protein fliS
HPY11_03890	COG4191	Histidine kinase
HPY11_03900	COG1677	Flagellar hook-basal body complex protein FliE
HPY11_03910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY11_03940	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY11_03965	COG1987	bacterial-type flagellum assembly
HPY11_03970	COG1684	flagellar biosynthetic protein fliR
HPY11_03980	COG2840	Smr protein MutS2
HPY11_03985	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY11_03990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY11_03995	COG2860	membrane
HPY11_04000	COG3101	peptidyl-lysine hydroxylation
HPY11_04010	COG0431	NADPH-dependent FMN reductase
HPY11_04015	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY11_04015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY11_04020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY11_04025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY11_04030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY11_04035	COG0735	belongs to the Fur family
HPY11_04045	COG0583	DNA-binding transcription factor activity
HPY11_04055	COG1346	cytolysis
HPY11_04070	COG0596	Alpha beta hydrolase
HPY11_04075	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY11_04080	COG0033	Phosphoglucomutase
HPY11_04090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY11_04095	COG0372	Belongs to the citrate synthase family
HPY11_04100	COG2009	succinate dehydrogenase
HPY11_04105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY11_04110	COG1053	succinate dehydrogenase
HPY11_04120	COG0567	Dehydrogenase, E1 component
HPY11_04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY11_04130	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY11_04140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY11_04145	COG1121	(ABC) transporter
HPY11_04150	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY11_04155	COG4977	sequence-specific DNA binding
HPY11_04160	COG1918	ferrous iron import across plasma membrane
HPY11_04180	COG0018	arginyl-trna synthetase
HPY11_04190	COG1025	Belongs to the peptidase M16 family
HPY11_04195	COG2062	phosphohistidine phosphatase, SixA
HPY11_04225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY11_04230	COG0784	Response regulator, receiver
HPY11_04230	COG2198	Histidine kinase
HPY11_04230	COG0643	Histidine kinase
HPY11_04235	COG2201	protein-glutamate methylesterase activity
HPY11_04240	COG1192	Involved in chromosome partitioning
HPY11_04250	COG0835	chemotaxis
HPY11_04260	COG4133	protoheme IX ABC transporter activity
HPY11_04265	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY11_04270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY11_04280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY11_04285	COG1138	Cytochrome C-type biogenesis protein
HPY11_04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY11_04295	COG3088	subunit of a heme lyase
HPY11_04295	COG4235	cytochrome complex assembly
HPY11_04305	COG2853	Lipoprotein
HPY11_04325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY11_04330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY11_04335	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY11_04350	COG3083	sulfuric ester hydrolase activity
HPY11_04355	COG3082	Protein of unknown function (DUF1414)
HPY11_04360	COG3081	Nucleoid-associated protein
HPY11_04370	COG1757	Na H antiporter
HPY11_04375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY11_04380	COG2095	MarC family integral membrane protein
HPY11_04385	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_04385	COG1454	alcohol dehydrogenase
HPY11_04395	COG0659	secondary active sulfate transmembrane transporter activity
HPY11_04400	COG1530	ribonuclease E activity
HPY11_04405	COG0564	pseudouridine synthase activity
HPY11_04410	COG0424	maF-like protein
HPY11_04415	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY11_04420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY11_04425	COG0416	fatty acid biosynthetic process
HPY11_04430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY11_04440	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_04445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY11_04450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY11_04455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY11_04460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY11_04465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY11_04475	COG0084	hydrolase, TatD family'
HPY11_04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_04480	COG1263	PTS System
HPY11_04490	COG0733	neurotransmitter:sodium symporter activity
HPY11_04505	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY11_04515	COG1940	carbohydrate kinase activity
HPY11_04520	COG0784	Response regulator, receiver
HPY11_04520	COG0835	chemotaxis
HPY11_04535	COG2226	methyltransferase
HPY11_04545	COG0676	glucose-6-phosphate 1-epimerase activity
HPY11_04550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY11_04555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_04565	COG3139	Protein of unknown function (DUF1315)
HPY11_04570	COG0252	asparaginase activity
HPY11_04575	COG0616	signal peptide processing
HPY11_04580	COG1902	pentaerythritol trinitrate reductase activity
HPY11_04580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY11_04585	COG0788	formyltetrahydrofolate deformylase activity
HPY11_04595	COG1199	ATP-dependent helicase activity
HPY11_04600	COG1214	PFAM Peptidase M22, glycoprotease
HPY11_04615	COG0596	Alpha beta hydrolase
HPY11_04620	COG0318	PFAM AMP-dependent synthetase and ligase
HPY11_04625	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY11_04640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY11_04645	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY11_04650	COG0436	Aminotransferase
HPY11_04655	COG1169	isochorismate synthase
HPY11_04660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY11_04665	COG0596	Alpha beta hydrolase
HPY11_04685	COG3135	benzoate transporter
HPY11_04710	COG3015	lipoprotein NlpE involved in copper resistance
HPY11_04715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY11_04720	COG2894	cell division
HPY11_04725	COG0850	regulation of cytokinetic process
HPY11_04730	COG3100	YcgL domain-containing protein
HPY11_04735	COG2951	lytic endotransglycosylase activity
HPY11_04745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY11_04750	COG3005	denitrification pathway
HPY11_04755	COG0243	molybdopterin cofactor binding
HPY11_04770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_04785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY11_04820	COG4589	Belongs to the CDS family
HPY11_04830	COG3300	MHYT domain
HPY11_04830	COG5001	Diguanylate cyclase
HPY11_04840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY11_04845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY11_04850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY11_04855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY11_04865	COG4191	Histidine kinase
HPY11_04875	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY11_04885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY11_04890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY11_04895	COG0776	regulation of translation
HPY11_04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY11_04905	COG1555	photosystem II stabilization
HPY11_04910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY11_04915	COG0539	negative regulation of cytoplasmic translation
HPY11_04920	COG0776	regulation of translation
HPY11_04925	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY11_04930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY11_04950	COG0583	DNA-binding transcription factor activity
HPY11_04960	COG0686	Belongs to the AlaDH PNT family
HPY11_04970	COG1674	ftsk spoiiie
HPY11_04975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY11_04980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY11_04985	COG2186	Transcriptional regulator
HPY11_05000	COG0537	adenosine 5'-monophosphoramidase activity
HPY11_05025	COG3150	esterase
HPY11_05030	COG1252	NADH dehydrogenase
HPY11_05055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY11_05065	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY11_05070	COG1136	(ABC) transporter
HPY11_05075	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY11_05085	COG0658	competence protein
HPY11_05085	COG2333	competence protein COMEC
HPY11_05090	COG1132	(ABC) transporter
HPY11_05095	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY11_05100	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY11_05105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY11_05110	COG2719	SpoVR family
HPY11_05115	COG2718	Belongs to the UPF0229 family
HPY11_05120	COG2766	serine protein kinase
HPY11_05125	COG3013	Belongs to the UPF0304 family
HPY11_05135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY11_05140	COG0840	transmembrane signaling receptor activity
HPY11_05150	COG1882	Formate acetyltransferase
HPY11_05175	COG4160	amino acid transport
HPY11_05180	COG0708	Exodeoxyribonuclease III
HPY11_05190	COG3923	Primosomal replication protein n
HPY11_05195	COG0730	response to heat
HPY11_05200	COG1199	ATP-dependent helicase activity
HPY11_05210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY11_05215	COG3012	SEC-C Motif Domain Protein
HPY11_05220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY11_05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_05230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY11_05235	COG0215	cysteine-tRNA ligase activity
HPY11_05240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY11_05245	COG0632	four-way junction helicase activity
HPY11_05255	COG1271	oxidase subunit
HPY11_05260	COG1294	oxidase, subunit
HPY11_05265	COG4890	Cyd operon protein YbgT
HPY11_05270	COG3790	cyd operon protein YbgE
HPY11_05275	COG0824	Thioesterase
HPY11_05280	COG0811	peptide transport
HPY11_05295	COG0823	Involved in the tonB-independent uptake of proteins
HPY11_05300	COG2885	chlorophyll binding
HPY11_05310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY11_05320	COG5002	protein histidine kinase activity
HPY11_05320	COG0784	Response regulator, receiver
HPY11_05330	COG1482	cell wall glycoprotein biosynthetic process
HPY11_05335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_05335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_05335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_05340	COG2207	Transcriptional regulator
HPY11_05350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_05355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_05360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_05370	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_05375	COG3284	Transcriptional regulator
HPY11_05380	COG4628	conserved protein (DUF2132)
HPY11_05390	COG0415	Belongs to the DNA photolyase family
HPY11_05425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_05435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY11_05435	COG3008	intermembrane lipid transfer
HPY11_05440	COG2995	paraquat-inducible protein a
HPY11_05445	COG0668	transmembrane transport
HPY11_05465	COG1309	transcriptional regulator
HPY11_05470	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_05490	COG1960	acyl-CoA dehydrogenase activity
HPY11_05495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY11_05500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY11_05510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY11_05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY11_05530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY11_05535	COG0297	glycogen (starch) synthase activity
HPY11_05555	COG3070	regulator of competence-specific genes
HPY11_05560	COG1609	Transcriptional regulator
HPY11_05570	COG0745	RESPONSE REGULATOR receiver
HPY11_05575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY11_05580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY11_05585	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY11_05590	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY11_05605	COG1280	lysine exporter protein (LysE YggA)
HPY11_05610	COG1032	radical SAM domain protein
HPY11_05615	COG5001	Diguanylate cyclase
HPY11_05620	COG0612	Peptidase, M16
HPY11_05635	COG0583	DNA-binding transcription factor activity
HPY11_05640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY11_05650	COG2350	Protein conserved in bacteria
HPY11_05655	COG1607	acyl-coa hydrolase
HPY11_05670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY11_05675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY11_05685	COG2116	formate transmembrane transporter activity
HPY11_05690	COG4459	periplasmic nitrate reductase
HPY11_05695	COG3005	denitrification pathway
HPY11_05700	COG0243	molybdopterin cofactor binding
HPY11_05720	COG1227	inorganic diphosphatase activity
HPY11_05740	COG4172	Belongs to the ABC transporter superfamily
HPY11_05755	COG4168	peptide transport system, permease
HPY11_05765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY11_05770	COG1842	Phage shock protein A
HPY11_05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_05800	COG2818	Glycosylase
HPY11_05805	COG0626	cystathionine gamma-synthase activity
HPY11_05815	COG0733	neurotransmitter:sodium symporter activity
HPY11_05840	COG0564	pseudouridine synthase activity
HPY11_05845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY11_05850	COG4136	ATPase activity
HPY11_05855	COG4135	transport system, permease component
HPY11_05860	COG4134	Bacterial extracellular solute-binding protein
HPY11_05870	COG3313	Fe-S protein
HPY11_05880	COG0814	amino acid
HPY11_05890	COG2239	Acts as a magnesium transporter
HPY11_05895	COG2205	protein histidine kinase activity
HPY11_05895	COG0784	Response regulator, receiver
HPY11_05910	COG4934	collagen metabolic process
HPY11_05945	COG0840	transmembrane signaling receptor activity
HPY11_05955	COG5001	Diguanylate cyclase
HPY11_05955	COG3706	GGDEF domain
HPY11_05955	COG2203	Gaf domain
HPY11_05955	COG4251	negative regulation of phosphorylation
HPY11_05960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY11_05980	COG1061	Type III restriction enzyme res subunit
HPY11_05985	COG1187	pseudouridine synthase activity
HPY11_05990	COG2814	Major facilitator Superfamily
HPY11_06000	COG0702	epimerase
HPY11_06005	COG0534	Mate efflux family protein
HPY11_06010	COG4181	ATPase activity
HPY11_06025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY11_06035	COG1748	Saccharopine dehydrogenase
HPY11_06050	COG1538	Outer membrane efflux protein
HPY11_06110	COG0583	DNA-binding transcription factor activity
HPY11_06120	COG1451	nucleotide metabolic process
HPY11_06135	COG3063	Type IV pilus biogenesis stability protein PilW
HPY11_06140	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY11_06160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_06175	COG3290	protein histidine kinase activity
HPY11_06180	COG4565	transcriptional regulatory protein
HPY11_06190	COG0784	Response regulator, receiver
HPY11_06190	COG0835	chemotaxis
HPY11_06240	COG1085	galactose-1-phosphate uridylyltransferase
HPY11_06245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY11_06250	COG2017	converts alpha-aldose to the beta-anomer
HPY11_06265	COG3527	Alpha-acetolactate decarboxylase
HPY11_06275	COG3064	Membrane
HPY11_06285	COG0753	catalase activity
HPY11_06305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY11_06315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY11_06355	COG1271	oxidase subunit
HPY11_06360	COG1294	oxidase, subunit
HPY11_06365	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY11_06365	COG1136	(ABC) transporter
HPY11_06370	COG1136	(ABC) transporter
HPY11_06370	COG0577	efflux transmembrane transporter activity
HPY11_06375	COG1136	(ABC) transporter
HPY11_06375	COG0577	efflux transmembrane transporter activity
HPY11_06395	COG0583	DNA-binding transcription factor activity
HPY11_06425	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HPY11_06465	COG2816	NAD+ diphosphatase activity
HPY11_06470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY11_06485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY11_06495	COG2723	6-phospho-beta-galactosidase activity
HPY11_06500	COG1609	Transcriptional regulator
HPY11_06505	COG0251	oxidation-reduction process
HPY11_06510	COG2731	YhcH YjgK YiaL family protein
HPY11_06515	COG0584	glycerophosphoryl diester phosphodiesterase
HPY11_06520	COG1349	DNA-binding transcription factor activity
HPY11_06525	COG3842	ATPase activity
HPY11_06530	COG0395	ABC-type sugar transport system, permease component
HPY11_06535	COG1175	transmembrane transport
HPY11_06550	COG0811	peptide transport
HPY11_06555	COG0811	peptide transport
HPY11_06560	COG0848	biopolymer transport protein
HPY11_06565	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY11_06575	COG1793	dna ligase
HPY11_06585	COG0534	Mate efflux family protein
HPY11_06595	COG3001	Fructosamine kinase
HPY11_06605	COG0791	NLP P60 protein
HPY11_06610	COG0840	transmembrane signaling receptor activity
HPY11_06625	COG1940	carbohydrate kinase activity
HPY11_06635	COG0303	'Molybdopterin
HPY11_06640	COG0746	molybdenum cofactor guanylyltransferase activity
HPY11_06645	COG3842	ATPase activity
HPY11_06650	COG4662	Binding-protein-dependent transport system inner membrane component
HPY11_06660	COG2204	response regulator
HPY11_06665	COG3852	Histidine kinase
HPY11_06670	COG0488	(ABC) transporter
HPY11_06680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY11_06710	COG3383	formate dehydrogenase (NAD+) activity
HPY11_06710	COG0243	molybdopterin cofactor binding
HPY11_06715	COG0437	4 iron, 4 sulfur cluster binding
HPY11_06730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY11_06735	COG1666	GTP binding
HPY11_06740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY11_06755	COG2996	Protein conserved in bacteria
HPY11_06765	COG3008	intermembrane lipid transfer
HPY11_06770	COG2995	paraquat-inducible protein a
HPY11_06775	COG1132	(ABC) transporter
HPY11_06780	COG1956	GAF domain-containing protein
HPY11_06785	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY11_06800	COG0308	aminopeptidase N
HPY11_06815	COG0167	dihydroorotate dehydrogenase activity
HPY11_06825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY11_06825	COG0116	Belongs to the methyltransferase superfamily
HPY11_06850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY11_06855	COG1067	ATP-dependent peptidase activity
HPY11_06860	COG3120	sequence-specific DNA binding
HPY11_06935	COG2994	toxin metabolic process
HPY11_06960	COG0784	Response regulator, receiver
HPY11_06960	COG2205	protein histidine kinase activity
HPY11_06975	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY11_06990	COG2010	Cytochrome c
HPY11_07000	COG2217	Heavy metal translocating P-type atpase
HPY11_07015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY11_07020	COG0589	response to stress
HPY11_07025	COG0037	tRNA processing
HPY11_07045	COG3842	ATPase activity
HPY11_07055	COG1177	transmembrane transport
HPY11_07065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY11_07080	COG1115	amino acid carrier protein
HPY11_07085	COG1280	lysine exporter protein (LysE YggA)
HPY11_07115	COG3501	Rhs element vgr protein
HPY11_07125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY11_07130	COG1960	acyl-CoA dehydrogenase activity
HPY11_07140	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_07145	COG3384	dioxygenase
HPY11_07180	COG3971	2-oxopent-4-enoate hydratase activity
HPY11_07200	COG1846	Transcriptional regulator
HPY11_07260	COG0513	Belongs to the DEAD box helicase family
HPY11_07265	COG2076	Multidrug Resistance protein
HPY11_07270	COG0477	Major facilitator Superfamily
HPY11_07275	COG0583	DNA-binding transcription factor activity
HPY11_07285	COG0402	S-adenosylhomocysteine deaminase activity
HPY11_07290	COG0095	Lipoate-protein ligase
HPY11_07295	COG0443	Heat shock 70 kDa protein
HPY11_07305	COG1643	Atp-dependent helicase
HPY11_07335	COG0443	Heat shock 70 kDa protein
HPY11_07340	COG0443	Heat shock 70 kDa protein
HPY11_07345	COG3706	GGDEF domain
HPY11_07375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY11_07380	COG0602	queuosine metabolic process
HPY11_07385	COG0561	phosphatase activity
HPY11_07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_07400	COG4597	amino acid ABC transporter
HPY11_07405	COG0765	amino acid transport
HPY11_07410	COG1126	abc transporter atp-binding protein
HPY11_07415	COG0670	Belongs to the BI1 family
HPY11_07420	COG2920	part of a sulfur-relay system
HPY11_07425	COG1254	Belongs to the acylphosphatase family
HPY11_07435	COG3706	GGDEF domain
HPY11_07445	COG4999	Histidine kinase
HPY11_07445	COG3850	Histidine kinase
HPY11_07445	COG3437	response regulator, receiver
HPY11_07445	COG2205	protein histidine kinase activity
HPY11_07450	COG3437	response regulator, receiver
HPY11_07455	COG0625	glutathione transferase activity
HPY11_07465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY11_07475	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY11_07505	COG0372	Belongs to the citrate synthase family
HPY11_07510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY11_07535	COG0583	DNA-binding transcription factor activity
HPY11_07540	COG4771	TonB-dependent receptor
HPY11_07565	COG1566	PFAM secretion protein HlyD family protein
HPY11_07585	COG1129	ABC transporter
HPY11_07610	COG0745	RESPONSE REGULATOR receiver
HPY11_07615	COG5002	protein histidine kinase activity
HPY11_07620	COG3713	MltA-interacting MipA family protein
HPY11_07625	COG2990	Protein conserved in bacteria
HPY11_07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_07635	COG4191	Histidine kinase
HPY11_07640	COG0471	metal ion transport
HPY11_07650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY11_07665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_07675	COG3768	UPF0283 membrane protein
HPY11_07680	COG3106	COG3106 Predicted ATPase
HPY11_07695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY11_07700	COG0494	nUDIX hydrolase
HPY11_07705	COG0814	amino acid
HPY11_07710	COG1760	l-serine dehydratase
HPY11_07715	COG0720	synthase
HPY11_07720	COG0840	transmembrane signaling receptor activity
HPY11_07725	COG0017	Asparaginyl-tRNA synthetase
HPY11_07730	COG0351	phosphomethylpyrimidine kinase
HPY11_07735	COG2770	Histidine kinase
HPY11_07735	COG3437	response regulator, receiver
HPY11_07740	COG1448	Aminotransferase
HPY11_07755	COG0840	transmembrane signaling receptor activity
HPY11_07760	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY11_07765	COG2943	transferase activity, transferring hexosyl groups
HPY11_07770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY11_07775	COG1846	Transcriptional regulator
HPY11_07800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY11_07815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY11_07820	COG3108	Peptidase M15
HPY11_07850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY11_07860	COG2814	Major facilitator Superfamily
HPY11_07880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY11_07885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY11_07890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY11_07935	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY11_07940	COG4139	cobalamin transport
HPY11_07945	COG2988	succinylglutamate desuccinylase activity
HPY11_07960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY11_07965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY11_07970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_07980	COG2925	Exonuclease
HPY11_07985	COG1380	Effector of murein hydrolase LrgA
HPY11_07990	COG1346	cytolysis
HPY11_08010	COG0500	methyltransferase
HPY11_08020	COG0776	regulation of translation
HPY11_08025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_08025	COG0072	phenylalanine-tRNA ligase activity
HPY11_08030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY11_08070	COG0322	excinuclease ABC activity
HPY11_08075	COG2197	response regulator
HPY11_08080	COG0417	DNA replication proofreading
HPY11_08095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY11_08100	COG3099	Belongs to the UPF0263 family
HPY11_08115	COG1228	amidohydrolase
HPY11_08120	COG0010	Belongs to the arginase family
HPY11_08125	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY11_08130	COG2986	histidine ammonia-lyase
HPY11_08150	COG0277	FAD linked oxidase domain protein
HPY11_08150	COG0247	lactate metabolic process
HPY11_08165	COG2885	chlorophyll binding
HPY11_08185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY11_08195	COG0281	malic enzyme
HPY11_08205	COG2949	membrane
HPY11_08210	COG3706	GGDEF domain
HPY11_08215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY11_08225	COG0492	ferredoxin-NADP+ reductase activity
HPY11_08230	COG4988	ABC transporter
HPY11_08235	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY11_08240	COG1187	pseudouridine synthase activity
HPY11_08245	COG0009	L-threonylcarbamoyladenylate synthase
HPY11_08250	COG0613	PHP domain protein
HPY11_08260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY11_08265	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY11_08270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY11_08275	COG0135	phosphoribosylanthranilate isomerase activity
HPY11_08275	COG0134	indole-3-glycerol-phosphate synthase activity
HPY11_08280	COG0133	tryptophan synthase activity
HPY11_08285	COG0159	tryptophan synthase activity
HPY11_08295	COG1435	thymidine kinase activity
HPY11_08300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY11_08305	COG1801	Protein of unknown function DUF72
HPY11_08310	COG4106	trans-aconitate 2-methyltransferase activity
HPY11_08315	COG0500	methyltransferase
HPY11_08320	COG0189	ligase activity
HPY11_08320	COG4067	protein conserved in archaea
HPY11_08335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY11_08345	COG3852	Histidine kinase
HPY11_08360	COG3070	regulator of competence-specific genes
HPY11_08370	COG2431	L-lysine efflux transmembrane transporter activity
HPY11_08380	COG0076	glutamate decarboxylase activity
HPY11_08385	COG1737	Transcriptional regulator
HPY11_08390	COG1454	alcohol dehydrogenase
HPY11_08390	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_08395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY11_08400	COG3273	potassium ion transport
HPY11_08400	COG2985	domain, Protein
HPY11_08405	COG0542	response to heat
HPY11_08410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY11_08415	COG1278	Cold shock
HPY11_08425	COG1187	pseudouridine synthase activity
HPY11_08430	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY11_08430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY11_08435	COG0107	imidazoleglycerol-phosphate synthase activity
HPY11_08440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY11_08445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY11_08450	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY11_08450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY11_08455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY11_08460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY11_08465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY11_08470	COG1757	Na H antiporter
HPY11_08475	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY11_08480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_08485	COG0482	sulfurtransferase activity
HPY11_08490	COG2915	High frequency lysogenization protein hflD homolog
HPY11_08495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY11_08505	COG2268	Band 7 protein
HPY11_08515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY11_08530	COG0300	oxidoreductase activity
HPY11_08540	COG0501	Belongs to the peptidase M48B family
HPY11_08550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY11_08555	COG2226	methyltransferase
HPY11_08560	COG0156	8-amino-7-oxononanoate synthase activity
HPY11_08565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY11_08570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY11_08575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY11_08580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY11_08585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY11_08595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY11_08600	COG2203	Gaf domain
HPY11_08600	COG2199	diguanylate cyclase activity
HPY11_08610	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY11_08620	COG4628	conserved protein (DUF2132)
HPY11_08625	COG3092	negative regulation of chromosome organization
HPY11_08630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY11_08635	COG0857	belongs to the CobB CobQ family
HPY11_08635	COG0280	phosphate acetyltransferase
HPY11_08640	COG0435	Glutathione S-transferase
HPY11_08645	COG4608	Belongs to the ABC transporter superfamily
HPY11_08650	COG0444	Belongs to the ABC transporter superfamily
HPY11_08655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_08660	COG0601	transmembrane transport
HPY11_08680	COG2204	response regulator
HPY11_08685	COG5001	Diguanylate cyclase
HPY11_08685	COG3300	MHYT domain
HPY11_08690	COG4191	Histidine kinase
HPY11_08695	COG5002	protein histidine kinase activity
HPY11_08705	COG2201	protein-glutamate methylesterase activity
HPY11_08720	COG0009	L-threonylcarbamoyladenylate synthase
HPY11_08735	COG1881	PFAM PEBP family protein
HPY11_08760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY11_08765	COG0640	Transcriptional regulator
HPY11_08835	COG0322	excinuclease ABC activity
HPY11_08875	COG3706	GGDEF domain
HPY11_08895	COG1946	Acyl-CoA thioesterase
HPY11_08900	COG1522	sequence-specific DNA binding
HPY11_08910	COG0616	signal peptide processing
HPY11_08915	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_08920	COG2983	Belongs to the UPF0260 family
HPY11_08930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY11_08935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY11_08945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY11_08950	COG2832	Protein of unknown function (DUF454)
HPY11_08955	COG0745	RESPONSE REGULATOR receiver
HPY11_08960	COG0583	DNA-binding transcription factor activity
HPY11_08965	COG0778	Nitroreductase
HPY11_08970	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY11_08970	COG1024	Enoyl-CoA hydratase
HPY11_08975	COG0183	Belongs to the thiolase family
HPY11_08990	COG2067	long-chain fatty acid transport protein
HPY11_09000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY11_09005	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY11_09010	COG2982	Protein involved in outer membrane biogenesis
HPY11_09015	COG0572	uridine kinase
HPY11_09020	COG0489	protein tyrosine kinase activity
HPY11_09025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_09025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_09035	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY11_09045	COG0617	tRNA 3'-terminal CCA addition
HPY11_09045	COG0517	IMP dehydrogenase activity
HPY11_09045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY11_09050	COG2199	diguanylate cyclase activity
HPY11_09055	COG0314	molybdopterin synthase activity
HPY11_09060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY11_09065	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY11_09070	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY11_09075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY11_09080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY11_09085	COG2198	Histidine kinase
HPY11_09090	COG2204	response regulator
HPY11_09095	COG0556	nucleotide-excision repair
HPY11_09105	COG4657	Part of a membrane complex involved in electron transport
HPY11_09110	COG2878	Part of a membrane complex involved in electron transport
HPY11_09115	COG4656	Part of a membrane complex involved in electron transport
HPY11_09130	COG4660	Part of a membrane complex involved in electron transport
HPY11_09135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY11_09140	COG0346	lactoylglutathione lyase activity
HPY11_09155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY11_09160	COG2056	Na+-H+ antiporter family
HPY11_09165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY11_09170	COG1286	toxin biosynthetic process
HPY11_09175	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY11_09180	COG0285	dihydrofolate synthase activity
HPY11_09185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY11_09190	COG0101	tRNA pseudouridine synthase activity
HPY11_09205	COG2190	(PTS) system
HPY11_09205	COG1263	PTS System
HPY11_09205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_09210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY11_09215	COG1846	Transcriptional regulator
HPY11_09215	COG1940	carbohydrate kinase activity
HPY11_09220	COG4651	solute:proton antiporter activity
HPY11_09220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY11_09225	COG0367	asparagine synthase
HPY11_09240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY11_09245	COG0563	adenylate kinase activity
HPY11_09250	COG0326	Molecular chaperone. Has ATPase activity
HPY11_09255	COG3710	Transcriptional regulator
HPY11_09270	COG0622	Phosphoesterase
HPY11_09275	COG1090	epimerase
HPY11_09280	COG0300	oxidoreductase activity
HPY11_09285	COG3118	belongs to the thioredoxin family
HPY11_09290	COG0330	HflC and HflK could
HPY11_09295	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY11_09300	COG0789	Transcriptional regulator
HPY11_09315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY11_09320	COG3115	cell septum assembly
HPY11_09325	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY11_09335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_09345	COG2190	(PTS) system
HPY11_09350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY11_09360	COG1702	phosphate starvation-inducible protein PhoH
HPY11_09370	COG4535	Mg2 and Co2 transporter CorC
HPY11_09375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY11_09380	COG2888	peptidyl-tyrosine sulfation
HPY11_09385	COG0495	leucyl-tRNA aminoacylation
HPY11_09390	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY11_09395	COG1466	dna polymerase III delta subunit
HPY11_09400	COG0799	negative regulation of ribosome biogenesis
HPY11_09405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY11_09410	COG0768	penicillin binding
HPY11_09415	COG0772	Belongs to the SEDS family
HPY11_09420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY11_09425	COG1686	Belongs to the peptidase S11 family
HPY11_09430	COG2921	Belongs to the UPF0250 family
HPY11_09435	COG0321	lipoyl(octanoyl) transferase activity
HPY11_09440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY11_09450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY11_09475	COG1596	polysaccharide export
HPY11_09485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY11_09515	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY11_09525	COG0438	transferase activity, transferring glycosyl groups
HPY11_09535	COG1045	serine acetyltransferase
HPY11_09555	COG0110	maltose O-acetyltransferase activity
HPY11_09560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY11_09565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY11_09570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY11_09575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY11_09605	COG0366	Alpha amylase catalytic
HPY11_09610	COG1263	PTS System
HPY11_09610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_09615	COG1609	Transcriptional regulator
HPY11_09620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY11_09625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY11_09630	COG2011	ABC-type metal ion transport system permease component
HPY11_09635	COG1464	Belongs to the NlpA lipoprotein family
HPY11_09640	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY11_09650	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY11_09650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY11_09660	COG3706	GGDEF domain
HPY11_09665	COG1611	Belongs to the LOG family
HPY11_09670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY11_09675	COG2363	Small membrane protein
HPY11_09680	COG0583	DNA-binding transcription factor activity
HPY11_09685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY11_09685	COG0301	tRNA thio-modification
HPY11_09695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY11_09700	COG1722	exodeoxyribonuclease VII activity
HPY11_09705	COG0142	geranyltranstransferase activity
HPY11_09710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY11_09715	COG0564	pseudouridine synthase activity
HPY11_09720	COG3098	single-species biofilm formation
HPY11_09735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_09745	COG1671	Belongs to the UPF0178 family
HPY11_09750	COG3385	transposase activity
HPY11_09755	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY11_09760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY11_09765	COG0254	rRNA binding
HPY11_09770	COG1720	tRNA m6t6A37 methyltransferase activity
HPY11_09775	COG0442	prolyl-tRNA aminoacylation
HPY11_09795	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY11_09795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY11_09805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY11_09815	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY11_09845	COG0484	heat shock protein binding
HPY11_09850	COG0443	Heat shock 70 kDa protein
HPY11_09855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY11_09860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY11_09865	COG0497	DNA recombination
HPY11_09870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_09875	COG2914	Belongs to the UPF0125 (RnfH) family
HPY11_09880	COG2867	negative regulation of translational initiation
HPY11_09885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY11_09905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPY11_09920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPY11_09935	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY11_09940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY11_09945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY11_09980	COG1115	amino acid carrier protein
HPY11_09985	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY11_09990	COG0583	DNA-binding transcription factor activity
HPY11_10000	COG1120	ATPase activity
HPY11_10005	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_10010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_10015	COG4592	Periplasmic binding protein
HPY11_10025	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_10030	COG1169	isochorismate synthase
HPY11_10035	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY11_10040	COG1535	isochorismatase
HPY11_10040	COG3433	isochorismatase activity
HPY11_10045	COG1584	GPR1 FUN34 yaaH family protein
HPY11_10055	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY11_10090	COG0464	growth
HPY11_10155	COG0582	viral genome integration into host DNA
HPY11_10160	COG0519	Catalyzes the synthesis of GMP from XMP
HPY11_10160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY11_10165	COG0516	GMP reductase activity
HPY11_10165	COG0517	IMP dehydrogenase activity
HPY11_10170	COG1570	exodeoxyribonuclease VII activity
HPY11_10185	COG1160	GTP binding
HPY11_10190	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_10195	COG2976	Protein conserved in bacteria
HPY11_10200	COG0124	histidyl-tRNA synthetase
HPY11_10205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY11_10220	COG0105	UTP biosynthetic process
HPY11_10225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY11_10230	COG2975	iron-sulfur cluster assembly
HPY11_10235	COG0633	Ferredoxin
HPY11_10255	COG0822	iron-sulfur transferase activity
HPY11_10260	COG1104	cysteine desulfurase activity
HPY11_10265	COG1959	2 iron, 2 sulfur cluster binding
HPY11_10275	COG0483	inositol monophosphate 1-phosphatase activity
HPY11_10280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_10285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_10290	COG1862	Preprotein translocase
HPY11_10300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY11_10305	COG0517	IMP dehydrogenase activity
HPY11_10315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY11_10320	COG0583	DNA-binding transcription factor activity
HPY11_10325	COG0450	alkyl hydroperoxide reductase
HPY11_10330	COG3142	Participates in the control of copper homeostasis
HPY11_10345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY11_10350	COG0581	inorganic phosphate transmembrane transporter activity
HPY11_10360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY11_10365	COG0248	Ppx GppA phosphatase
HPY11_10375	COG5002	protein histidine kinase activity
HPY11_10380	COG0745	RESPONSE REGULATOR receiver
HPY11_10395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY11_10440	COG0542	response to heat
HPY11_10450	COG0564	pseudouridine synthase activity
HPY11_10455	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_10460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY11_10465	COG1605	Chorismate mutase
HPY11_10465	COG0077	Prephenate dehydratase
HPY11_10470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY11_10475	COG5001	Diguanylate cyclase
HPY11_10485	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY11_10495	COG0488	(ABC) transporter
HPY11_10505	COG0287	Prephenate dehydrogenase
HPY11_10505	COG1605	Chorismate mutase
HPY11_10510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY11_10515	COG3275	phosphorelay sensor kinase activity
HPY11_10520	COG3279	Response regulator of the LytR AlgR family
HPY11_10530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY11_10535	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY11_10550	COG1966	Carbon starvation protein
HPY11_10555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY11_10560	COG1047	Peptidyl-prolyl cis-trans
HPY11_10565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY11_10575	COG0196	riboflavin kinase activity
HPY11_10580	COG0728	peptidoglycan biosynthetic process
HPY11_10585	COG0268	Binds directly to 16S ribosomal RNA
HPY11_10590	COG0640	Transcriptional regulator
HPY11_10595	COG0583	DNA-binding transcription factor activity
HPY11_10600	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY11_10610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY11_10615	COG0730	response to heat
HPY11_10620	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY11_10625	COG0494	nUDIX hydrolase
HPY11_10635	COG0667	Aldo Keto reductase
HPY11_10645	COG2204	response regulator
HPY11_10650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY11_10670	COG0513	Belongs to the DEAD box helicase family
HPY11_10695	COG3153	acetyltransferase
HPY11_10700	COG3154	lipid carrier protein
HPY11_10710	COG0826	peptidase U32
HPY11_10715	COG0826	peptidase U32
HPY11_10730	COG3385	transposase activity
HPY11_10745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY11_10755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY11_10760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY11_10765	COG0195	Participates in both transcription termination and antitermination
HPY11_10770	COG0779	Required for maturation of 30S ribosomal subunits
HPY11_10785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY11_10795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY11_10800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY11_10805	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY11_10810	COG1534	Rna-binding protein
HPY11_10815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY11_10820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY11_10825	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY11_10830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY11_10835	COG0739	heme binding
HPY11_10850	COG0316	Belongs to the HesB IscA family
HPY11_10860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY11_10865	COG0628	permease
HPY11_10870	COG2813	Specifically methylates the guanine in position
HPY11_10880	COG0747	negative chemotaxis
HPY11_10890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_10895	COG0444	Belongs to the ABC transporter superfamily
HPY11_10900	COG4608	Belongs to the ABC transporter superfamily
HPY11_10910	COG2971	BadF BadG BcrA BcrD
HPY11_10930	COG3842	ATPase activity
HPY11_10940	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY11_10945	COG0004	ammonium transporteR
HPY11_10950	COG0347	Belongs to the P(II) protein family
HPY11_10955	COG3112	Uncharacterised protein family (UPF0231)
HPY11_10960	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY11_10965	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY11_10970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY11_10975	COG1643	Atp-dependent helicase
HPY11_10985	COG1489	DNA binding
HPY11_10995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY11_11005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY11_11010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY11_11015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY11_11020	COG0842	Transport permease protein
HPY11_11025	COG1131	(ABC) transporter
HPY11_11030	COG0659	secondary active sulfate transmembrane transporter activity
HPY11_11035	COG0288	reversible hydration of carbon dioxide
HPY11_11050	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY11_11055	COG3107	peptidoglycan biosynthetic process
HPY11_11060	COG0792	nuclease activity
HPY11_11065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY11_11070	COG2823	Periplasmic or secreted lipoprotein
HPY11_11075	COG2969	positive regulation of protein catabolic process
HPY11_11080	COG0625	glutathione transferase activity
HPY11_11085	COG2857	Cytochrome c1
HPY11_11090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY11_11095	COG0723	plastoquinol--plastocyanin reductase activity
HPY11_11100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY11_11105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY11_11110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY11_11120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY11_11125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY11_11130	COG0335	large ribosomal subunit rRNA binding
HPY11_11135	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY11_11140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY11_11145	COG0228	four-way junction DNA binding
HPY11_11150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY11_11155	COG4137	Cytochrome C assembly protein
HPY11_11160	COG4536	flavin adenine dinucleotide binding
HPY11_11165	COG1854	S-ribosylhomocysteine lyase activity
HPY11_11170	COG2918	glutathione biosynthetic process
HPY11_11175	COG0612	Peptidase, M16
HPY11_11180	COG1238	metal cluster binding
HPY11_11190	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY11_11195	COG5016	pyruvate
HPY11_11195	COG0511	ligase activity, forming carbon-carbon bonds
HPY11_11200	COG3630	sodium ion export across plasma membrane
HPY11_11245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY11_11250	COG0527	aspartate kinase activity
HPY11_11255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY11_11260	COG2137	regulation of response to DNA damage stimulus
HPY11_11265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY11_11275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY11_11280	COG4208	sulfate ABC transporter
HPY11_11300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY11_11305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY11_11315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY11_11320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY11_11325	COG0585	pseudouridine synthase activity
HPY11_11330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY11_11335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY11_11340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY11_11345	COG1968	undecaprenyl-diphosphatase activity
HPY11_11350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY11_11355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY11_11360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY11_11370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY11_11375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY11_11380	COG1610	YqeY-like protein
HPY11_11405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY11_11410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY11_11415	COG1349	DNA-binding transcription factor activity
HPY11_11435	COG1279	arginine transmembrane transporter activity
HPY11_11440	COG0668	transmembrane transport
HPY11_11445	COG0191	fructose-bisphosphate aldolase activity
HPY11_11450	COG0126	phosphoglycerate kinase activity
HPY11_11455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY11_11460	COG4771	TonB-dependent receptor
HPY11_11465	COG0583	DNA-binding transcription factor activity
HPY11_11470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY11_11475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY11_11485	COG2356	endonuclease I
HPY11_11490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY11_11495	COG0189	ligase activity
HPY11_11500	COG1678	Uncharacterized ACR, COG1678
HPY11_11505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY11_11510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY11_11530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY11_11535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY11_11540	COG0762	integral membrane protein
HPY11_11555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY11_11560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY11_11565	COG2066	Belongs to the glutaminase family
HPY11_11570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY11_11575	COG1194	a g-specific adenine glycosylase
HPY11_11580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY11_11585	COG0741	lytic transglycosylase activity
HPY11_11640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY11_11645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY11_11650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY11_11655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY11_11660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY11_11665	COG2967	ApaG domain
HPY11_11670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY11_11680	COG3610	response to peptide
HPY11_11685	COG2966	Psort location CytoplasmicMembrane, score
HPY11_11690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY11_11695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY11_11700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY11_11705	COG0142	geranyltranstransferase activity
HPY11_11710	COG0531	amino acid
HPY11_11715	COG0039	L-malate dehydrogenase activity
HPY11_11720	COG1438	arginine binding
HPY11_11725	COG2358	TRAP transporter, solute receptor (TAXI family
HPY11_11735	COG0589	response to stress
HPY11_11755	COG2235	arginine
HPY11_11760	COG0312	modulator of DNA gyrase
HPY11_11765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY11_11770	COG3164	Protein of unknown function
HPY11_11775	COG1530	ribonuclease E activity
HPY11_11780	COG0424	maF-like protein
HPY11_11785	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY11_11790	COG1792	Involved in formation and maintenance of cell shape
HPY11_11795	COG1077	Cell shape determining protein MreB Mrl
HPY11_11840	COG1459	type II secretion system
HPY11_11845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY11_11855	COG3409	Peptidoglycan-binding domain 1 protein
HPY11_11855	COG3267	Type II secretory pathway component ExeA
HPY11_11910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY11_11915	COG0527	aspartate kinase activity
HPY11_11920	COG1410	methionine synthase
HPY11_11920	COG0646	methionine synthase
HPY11_11995	COG0175	sulfate reduction
HPY11_12005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY11_12030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY11_12035	COG0735	belongs to the Fur family
HPY11_12050	COG0166	Belongs to the GPI family
HPY11_12055	COG0432	Pfam Uncharacterised protein family UPF0047
HPY11_12060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY11_12075	COG0359	binds to the 23S rRNA
HPY11_12080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY11_12085	COG2965	DNA replication, synthesis of RNA primer
HPY11_12090	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY11_12100	COG2906	2 iron, 2 sulfur cluster binding
HPY11_12105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY11_12110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY11_12115	COG0049	tRNA binding
HPY11_12130	COG2923	Belongs to the DsrF TusC family
HPY11_12135	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY11_12140	COG2964	Protein conserved in bacteria
HPY11_12145	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY11_12155	COG2900	Belongs to the SlyX family
HPY11_12160	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY11_12165	COG0330	HflC and HflK could
HPY11_12170	COG0330	HflC and HflK could
HPY11_12175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY11_12180	COG1923	regulation of RNA biosynthetic process
HPY11_12185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY11_12190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY11_12200	COG0802	atpase or kinase
HPY11_12205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY11_12255	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY11_12260	COG1162	GTPase activity
HPY11_12265	COG0688	phosphatidylethanolamine metabolic process
HPY11_12270	COG0471	metal ion transport
HPY11_12280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY11_12285	COG4942	peptidase
HPY11_12300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY11_12305	COG2816	NAD+ diphosphatase activity
HPY11_12310	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY11_12315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY11_12320	COG0085	RNA polymerase activity
HPY11_12325	COG0222	ribosome binding
HPY11_12330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY11_12340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY11_12345	COG0250	Participates in transcription elongation, termination and antitermination
HPY11_12350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY11_12355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY11_12380	COG1072	(Pantothenic acid kinase))
HPY11_12390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY11_12400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY11_12445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY11_12460	COG3118	belongs to the thioredoxin family
HPY11_12465	COG0513	Belongs to the DEAD box helicase family
HPY11_12470	COG0248	Ppx GppA phosphatase
HPY11_12475	COG0784	Response regulator, receiver
HPY11_12475	COG2205	protein histidine kinase activity
HPY11_12480	COG2814	Major facilitator Superfamily
HPY11_12495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY11_12500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY11_12505	COG0511	ligase activity, forming carbon-carbon bonds
HPY11_12510	COG0439	Biotin carboxylase
HPY11_12515	COG2264	protein methyltransferase activity
HPY11_12520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY11_12525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY11_12535	COG1609	Transcriptional regulator
HPY11_12545	COG0129	dihydroxy-acid dehydratase activity
HPY11_12550	COG3265	gluconokinase activity
HPY11_12560	COG0800	Aldolase
HPY11_12580	COG0840	transmembrane signaling receptor activity
HPY11_12585	COG1982	Orn Lys Arg decarboxylase major
HPY11_12590	COG0531	amino acid
HPY11_12595	COG3710	Transcriptional regulator
HPY11_12600	COG0789	Transcriptional regulator
HPY11_12615	COG0151	Belongs to the GarS family
HPY11_12625	COG0776	regulation of translation
HPY11_12630	COG1253	flavin adenine dinucleotide binding
HPY11_12635	COG3068	Protein conserved in bacteria
HPY11_12645	COG1573	uracil-dna glycosylase
HPY11_12650	COG0668	transmembrane transport
HPY11_12655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY11_12665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPY11_12685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY11_12690	COG1215	transferase activity, transferring glycosyl groups
HPY11_12705	COG1215	transferase activity, transferring glycosyl groups
HPY11_12725	COG1596	polysaccharide export
HPY11_12745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_12775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY11_12795	COG2226	methyltransferase
HPY11_12830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY11_12850	COG0859	PFAM glycosyl transferase family 9
HPY11_12860	COG1519	Transferase
HPY11_12865	COG0456	acetyltransferase
HPY11_12870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY11_12885	COG3642	lipopolysaccharide core region biosynthetic process
HPY11_12890	COG0859	PFAM glycosyl transferase family 9
HPY11_12895	COG0463	Glycosyl transferase, family 2
HPY11_12900	COG0859	PFAM glycosyl transferase family 9
HPY11_12905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY11_12910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY11_12920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY11_12925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY11_12930	COG2003	Belongs to the UPF0758 family
HPY11_12940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY11_12950	COG1309	transcriptional regulator
HPY11_12955	COG1560	Kdo2-lipid A biosynthetic process
HPY11_12960	COG1560	Kdo2-lipid A biosynthetic process
HPY11_12965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY11_12970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY11_12975	COG1561	YicC-like family, N-terminal region
HPY11_13030	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPY11_13080	COG2862	Uncharacterized protein family, UPF0114
HPY11_13085	COG3385	transposase activity
HPY11_13090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY11_13095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_13095	COG1263	PTS System
HPY11_13100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY11_13115	COG0514	ATP-dependent DNA helicase (RecQ)
HPY11_13120	COG2962	Rard protein
HPY11_13125	COG0405	Gamma-glutamyltransferase
HPY11_13135	COG1280	lysine exporter protein (LysE YggA)
HPY11_13140	COG0210	DNA helicase
HPY11_13150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY11_13155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_13165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_13175	COG0747	negative chemotaxis
HPY11_13270	COG4964	Belongs to the GSP D family
HPY11_13305	COG1309	transcriptional regulator
HPY11_13310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_13315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY11_13320	COG2960	long-chain fatty acid transporting porin activity
HPY11_13325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY11_13330	COG0583	DNA-binding transcription factor activity
HPY11_13395	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY11_13400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY11_13405	COG1739	Uncharacterized protein family UPF0029
HPY11_13410	COG1024	Enoyl-CoA hydratase
HPY11_13410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY11_13415	COG0183	Belongs to the thiolase family
HPY11_13420	COG0583	DNA-binding transcription factor activity
HPY11_13425	COG2814	Major facilitator Superfamily
HPY11_13435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY11_13440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY11_13445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY11_13450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY11_13455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY11_13460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY11_13470	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY11_13475	COG3312	ion transport
HPY11_13480	COG1475	DNA binding
HPY11_13485	COG1192	Involved in chromosome partitioning
HPY11_13490	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY11_13495	COG0445	tRNA wobble uridine modification
HPY11_13500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY11_13595	COG4974	Belongs to the 'phage' integrase family
HPY11_13600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY11_13605	COG0706	membrane insertase activity
HPY11_13615	COG0594	ribonuclease P activity
HPY11_13620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY11_13625	COG1126	abc transporter atp-binding protein
HPY11_13670	COG0217	transcriptional regulatory protein
HPY11_13675	COG2084	Dehydrogenase
HPY11_13690	COG2909	trisaccharide binding
HPY11_13695	COG0058	SHG alpha-glucan phosphorylase activity
HPY11_13700	COG1640	4-alpha-glucanotransferase
HPY11_13705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY11_13715	COG3501	Rhs element vgr protein
HPY11_13750	COG0471	metal ion transport
HPY11_13755	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY11_13785	COG0671	phosphoesterase, PA-phosphatase related
HPY11_13795	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY11_13805	COG1999	signal sequence binding
HPY11_13820	COG0786	glutamate:sodium symporter activity
HPY11_13840	COG1566	PFAM secretion protein HlyD family protein
HPY11_13850	COG3706	GGDEF domain
HPY11_13865	COG0813	purine-nucleoside phosphorylase activity
HPY11_13870	COG3272	Protein of unknown function (DUF1722)
HPY11_13880	COG0415	Belongs to the DNA photolyase family
HPY11_13885	COG1388	LysM domain
HPY11_13885	COG1376	ErfK ybiS ycfS ynhG family protein
HPY11_13895	COG0513	Belongs to the DEAD box helicase family
HPY11_13900	COG1770	oligopeptidase
HPY11_13930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY11_13935	COG0573	inorganic phosphate transmembrane transporter activity
HPY11_13940	COG0581	inorganic phosphate transmembrane transporter activity
HPY11_13945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY11_13965	COG0659	secondary active sulfate transmembrane transporter activity
HPY11_13975	COG0739	heme binding
HPY11_13980	COG3300	MHYT domain
HPY11_13980	COG5001	Diguanylate cyclase
HPY11_13985	COG0583	DNA-binding transcription factor activity
HPY11_13990	COG2814	Major facilitator Superfamily
HPY11_14010	COG1301	dicarboxylic acid transport
HPY11_14025	COG1342	Belongs to the UPF0251 family
HPY11_14055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY11_14060	COG0673	inositol 2-dehydrogenase activity
HPY11_14070	COG2771	luxR family
HPY11_14070	COG2200	EAL domain
HPY11_14075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY11_14085	COG0564	pseudouridine synthase activity
HPY11_14190	COG1869	D-ribose catabolic process
HPY11_14195	COG1129	ABC transporter
HPY11_14200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY11_14205	COG1879	ABC-type sugar transport system periplasmic component
HPY11_14210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_14215	COG1609	Transcriptional regulator
HPY11_14225	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY11_14235	COG0584	glycerophosphoryl diester phosphodiesterase
HPY11_14240	COG2271	Major facilitator Superfamily
HPY11_14275	COG0579	oxidoreductase
HPY11_14285	COG0242	peptide deformylase activity
HPY11_14290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY11_14290	COG1017	nitric oxide dioxygenase activity
HPY11_14295	COG1320	monovalent cation:proton antiporter activity
HPY11_14300	COG2212	antiporter activity
HPY11_14320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY11_14320	COG2111	Na H antiporter
HPY11_14330	COG0589	response to stress
HPY11_14335	COG0814	amino acid
HPY11_14350	COG3530	Putative quorum-sensing-regulated virulence factor
HPY11_14360	COG5002	protein histidine kinase activity
HPY11_14360	COG5001	Diguanylate cyclase
HPY11_14365	COG1278	Cold shock
HPY11_14380	COG2304	oxidoreductase activity
HPY11_14400	COG0714	Associated with various cellular activities
HPY11_14405	COG0840	transmembrane signaling receptor activity
HPY11_14420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY11_14425	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY11_14435	COG3604	Transcriptional regulator
HPY11_14440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY11_14440	COG1017	nitric oxide dioxygenase activity
HPY11_14445	COG1278	Cold shock
HPY11_14450	COG3036	rescue of stalled ribosome
HPY11_14475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY11_14475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY11_14480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY11_14490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY11_14500	COG0516	GMP reductase activity
HPY11_14525	COG0513	Belongs to the DEAD box helicase family
HPY11_14530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY11_14535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY11_14540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY11_14545	COG0784	Response regulator, receiver
HPY11_14545	COG3437	response regulator, receiver
HPY11_14550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_14550	COG4191	Histidine kinase
HPY11_14560	COG1757	Na H antiporter
HPY11_14565	COG2814	Major facilitator Superfamily
HPY11_14575	COG3706	GGDEF domain
HPY11_14580	COG3240	lipase activity
HPY11_14595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY11_14600	COG5380	lipid catabolic process
HPY11_14625	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_14630	COG4605	iron ion homeostasis
HPY11_14635	COG4604	ABC transporter, ATP-binding protein
HPY11_14640	COG2207	Transcriptional regulator
HPY11_14655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY11_14670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY11_14680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_14690	COG0583	DNA-binding transcription factor activity
HPY11_14705	COG0745	RESPONSE REGULATOR receiver
HPY11_14715	COG3623	hexulose-6-phosphate isomerase
HPY11_14720	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY11_14725	COG0561	phosphatase activity
HPY11_14760	COG0366	Alpha amylase catalytic
HPY11_14780	COG0745	RESPONSE REGULATOR receiver
HPY11_14835	COG1686	Belongs to the peptidase S11 family
HPY11_14855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY11_14855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY11_14860	COG0509	glycine decarboxylation via glycine cleavage system
HPY11_14865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY11_14875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY11_14890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY11_14895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY11_14970	COG0346	lactoylglutathione lyase activity
HPY11_15295	COG0625	glutathione transferase activity
HPY11_15360	COG0384	phenazine biosynthesis protein PhzF
HPY11_15365	COG0346	lactoylglutathione lyase activity
HPY11_15415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_15540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_15705	COG3040	lipid binding
HPY11_15720	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY11_15795	COG0346	lactoylglutathione lyase activity
HPY11_15870	COG0456	acetyltransferase
HPY11_15915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_15915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_15920	COG0494	nUDIX hydrolase
HPY11_15945	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_15960	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY11_15995	COG0384	phenazine biosynthesis protein PhzF
HPY11_16145	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY11_16170	COG0384	phenazine biosynthesis protein PhzF
HPY11_16180	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY11_16185	COG2944	sequence-specific DNA binding
HPY11_16250	COG0346	lactoylglutathione lyase activity
HPY11_16285	COG0384	phenazine biosynthesis protein PhzF
HPY11_16310	COG5642	Protein of unknown function (DUF2384)
HPY11_16315	COG0384	phenazine biosynthesis protein PhzF
HPY11_16335	COG0494	nUDIX hydrolase
HPY11_16340	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY11_16350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_16350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_16380	COG3040	lipid binding
HPY11_16430	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY11_16445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY11_16450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_16455	COG1621	beta-fructofuranosidase activity
HPY11_16465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_16465	COG1263	PTS System
HPY11_16545	COG0778	Nitroreductase
HPY11_16550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY11_16555	COG0583	DNA-binding transcription factor activity
HPY11_16580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY11_16615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY11_16625	COG2390	Transcriptional regulator
HPY11_16635	COG2897	thiosulfate sulfurtransferase activity
HPY11_16645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY11_16655	COG0302	gtp cyclohydrolase
HPY11_16660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_16660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_16665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY11_16670	COG1970	mechanosensitive ion channel activity
HPY11_16675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY11_16685	COG1011	Hydrolase
HPY11_16690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY11_16695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY11_16705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY11_16715	COG3842	ATPase activity
HPY11_16735	COG3104	oligopeptide transport
HPY11_16760	COG4166	transmembrane transport
HPY11_16765	COG4174	ABC transporter (Permease)
HPY11_16770	COG4239	(ABC) transporter, permease
HPY11_16775	COG4172	Belongs to the ABC transporter superfamily
HPY11_16780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY11_16795	COG0625	glutathione transferase activity
HPY11_16815	COG2050	protein possibly involved in aromatic compounds catabolism
HPY11_16835	COG4771	TonB-dependent receptor
HPY11_16835	COG1629	transport
HPY11_16840	COG0583	DNA-binding transcription factor activity
HPY11_16845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_16845	COG1042	CoA-binding domain protein
HPY11_16845	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY11_16865	COG0023	Translation Initiation Factor
HPY11_16920	COG3140	Belongs to the UPF0181 family
HPY11_16935	COG0745	RESPONSE REGULATOR receiver
HPY11_16945	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY11_16950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY11_16965	COG3706	GGDEF domain
HPY11_17020	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY11_17025	COG3385	transposase activity
HPY11_17040	COG0737	Belongs to the 5'-nucleotidase family
HPY11_17045	COG3593	DNA synthesis involved in DNA repair
HPY11_17055	COG0583	DNA-binding transcription factor activity
HPY11_17060	COG2116	formate transmembrane transporter activity
HPY11_17070	COG3038	cytochrome b561
HPY11_17080	COG2200	EAL domain
HPY11_17095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY11_17100	COG0745	RESPONSE REGULATOR receiver
HPY11_17105	COG2205	protein histidine kinase activity
HPY11_17110	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY11_17110	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY11_17110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY11_17110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY11_17115	COG3158	transport of potassium into the cell
HPY11_17125	COG0523	cobalamin synthesis protein
HPY11_17130	COG0038	chloride channel
HPY11_17140	COG0156	8-amino-7-oxononanoate synthase activity
HPY11_17145	COG2205	protein histidine kinase activity
HPY11_17145	COG0784	Response regulator, receiver
HPY11_17150	COG0419	ATPase involved in DNA repair
HPY11_17155	COG0420	3'-5' exonuclease activity
HPY11_17160	COG1609	Transcriptional regulator
HPY11_17165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_17165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_17170	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY11_17175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_17175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_17175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY11_17180	COG0189	ligase activity
HPY11_17180	COG4067	protein conserved in archaea
HPY11_17190	COG0602	queuosine metabolic process
HPY11_17195	COG1328	CTP reductase activity
HPY11_17205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY11_17210	COG0840	transmembrane signaling receptor activity
HPY11_17215	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY11_17220	COG1760	l-serine dehydratase
HPY11_17225	COG2197	response regulator
HPY11_17230	COG3850	Histidine kinase
HPY11_17235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY11_17245	COG0243	molybdopterin cofactor binding
HPY11_17265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY11_17270	COG2197	response regulator
HPY11_17275	COG3851	Histidine kinase
HPY11_17280	COG2271	Major facilitator Superfamily
HPY11_17285	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY11_17295	COG3842	ATPase activity
HPY11_17300	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY11_17310	COG0183	Belongs to the thiolase family
HPY11_17320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_17325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_17340	COG3706	GGDEF domain
HPY11_17345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY11_17355	COG1979	alcohol dehydrogenase
HPY11_17370	COG4191	Histidine kinase
HPY11_17380	COG2271	Major facilitator Superfamily
HPY11_17385	COG0469	pyruvate kinase activity
HPY11_17395	COG1879	ABC-type sugar transport system periplasmic component
HPY11_17400	COG1803	Methylglyoxal synthase
HPY11_17405	COG1335	isochorismatase
HPY11_17410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY11_17415	COG0210	DNA helicase
HPY11_17420	COG1289	transmembrane transporter activity
HPY11_17450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY11_17455	COG4149	molybdate abc transporter
HPY11_17460	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY11_17465	COG1492	cobalamin metabolic process
HPY11_17515	COG2814	Major facilitator Superfamily
HPY11_17520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY11_17520	COG3433	isochorismatase activity
HPY11_17520	COG2226	methyltransferase
HPY11_17545	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY11_17550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY11_17570	COG1132	(ABC) transporter
HPY11_17575	COG1132	(ABC) transporter
HPY11_17585	COG0784	Response regulator, receiver
HPY11_17585	COG5002	protein histidine kinase activity
HPY11_17590	COG1879	ABC-type sugar transport system periplasmic component
HPY11_17600	COG2827	Endonuclease containing a URI domain
HPY11_17605	COG3132	Protein of unknown function, DUF480
HPY11_17615	COG2926	Belongs to the UPF0265 family
HPY11_17625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY11_17630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY11_17635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY11_17640	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPY11_17645	COG0247	lactate metabolic process
HPY11_17650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY11_17655	COG3118	belongs to the thioredoxin family
HPY11_17680	COG4160	amino acid transport
HPY11_17685	COG4215	(ABC) transporter
HPY11_17690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_17695	COG1126	abc transporter atp-binding protein
HPY11_17705	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY11_17715	COG0494	nUDIX hydrolase
HPY11_17720	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY11_17730	COG1309	transcriptional regulator
HPY11_17735	COG0513	Belongs to the DEAD box helicase family
HPY11_17740	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY11_17745	COG0814	amino acid
HPY11_17750	COG0840	transmembrane signaling receptor activity
HPY11_17755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY11_17760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY11_17770	COG1984	allophanate hydrolase subunit 2
HPY11_17785	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY11_17790	COG4181	ATPase activity
HPY11_17800	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY11_17805	COG1716	ATPase activity
HPY11_17805	COG5001	Diguanylate cyclase
HPY11_17815	COG0484	heat shock protein binding
HPY11_17830	COG0546	phosphoglycolate phosphatase activity
HPY11_17845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_17850	COG1368	sulfuric ester hydrolase activity
HPY11_17860	COG0513	Belongs to the DEAD box helicase family
HPY11_17875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY11_17885	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY11_17890	COG3397	chitin binding
HPY11_17895	COG3227	Zinc metalloprotease (Elastase)
HPY11_17910	COG1166	arginine decarboxylase activity
HPY11_17920	COG2239	Acts as a magnesium transporter
HPY11_17930	COG0527	aspartate kinase activity
HPY11_17940	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY11_17945	COG3186	Phenylalanine-4-hydroxylase
HPY11_17950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY11_17965	COG2264	protein methyltransferase activity
HPY11_17990	COG1253	flavin adenine dinucleotide binding
HPY11_17995	COG1765	OsmC-like protein
HPY11_18020	COG0531	amino acid
HPY11_18025	COG3706	GGDEF domain
HPY11_18035	COG4989	oxidoreductase activity
HPY11_18040	COG0366	Alpha amylase catalytic
HPY11_18050	COG2067	long-chain fatty acid transport protein
HPY11_18055	COG2267	carboxylic ester hydrolase activity
HPY11_18065	COG3227	Zinc metalloprotease (Elastase)
HPY11_18070	COG3047	cAMP biosynthetic process
HPY11_18080	COG1686	Belongs to the peptidase S11 family
HPY11_18085	COG0557	exoribonuclease II activity
HPY11_18090	COG1278	Cold shock
HPY11_18100	COG3048	D-serine ammonia-lyase activity
HPY11_18105	COG0583	DNA-binding transcription factor activity
HPY11_18125	COG2801	Transposase and inactivated derivatives
HPY11_18130	COG5002	protein histidine kinase activity
HPY11_18155	COG0582	viral genome integration into host DNA
HPY11_18175	COG1063	alcohol dehydrogenase
HPY11_18180	COG0156	8-amino-7-oxononanoate synthase activity
HPY11_18185	COG2873	o-acetylhomoserine
HPY11_18195	COG0346	lactoylglutathione lyase activity
HPY11_18220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY11_18225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY11_18230	COG0363	glucosamine-6-phosphate deaminase activity
HPY11_18235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY11_18260	COG1929	Belongs to the glycerate kinase type-1 family
HPY11_18265	COG2610	gluconate transmembrane transporter activity
HPY11_18270	COG3835	regulator
HPY11_18280	COG0748	coenzyme F420 binding
HPY11_18285	COG3721	Heme iron utilization protein
HPY11_18295	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY11_18300	COG0811	peptide transport
HPY11_18305	COG0848	biopolymer transport protein
HPY11_18310	COG4558	Periplasmic binding protein
HPY11_18315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_18320	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY11_18355	COG3217	Mosc domain protein beta barrel domain protein
HPY11_18355	COG0633	Ferredoxin
HPY11_18355	COG3217	Mosc domain protein beta barrel domain protein
HPY11_18355	COG0633	Ferredoxin
HPY11_18360	COG0418	dihydroorotase activity
HPY11_18365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY11_18370	COG2354	Protein conserved in bacteria
HPY11_18380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY11_18385	COG1278	Cold shock
HPY11_18410	COG3706	GGDEF domain
HPY11_18415	COG1349	DNA-binding transcription factor activity
HPY11_18430	COG3833	ABC-type maltose transport systems, permease component
HPY11_18435	COG1175	transmembrane transport
HPY11_18445	COG3842	ATPase activity
HPY11_18450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_18465	COG0393	Putative heavy-metal-binding
HPY11_18475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY11_18480	COG0835	chemotaxis
HPY11_18480	COG0784	Response regulator, receiver
HPY11_18485	COG1846	Transcriptional regulator
HPY11_18490	COG3706	GGDEF domain
HPY11_18525	COG0583	DNA-binding transcription factor activity
HPY11_18530	COG5001	Diguanylate cyclase
HPY11_18540	COG1741	Belongs to the pirin family
HPY11_18545	COG3123	guanosine phosphorylase activity
HPY11_18555	COG2211	Major facilitator Superfamily
HPY11_18560	COG0840	transmembrane signaling receptor activity
HPY11_18565	COG1067	ATP-dependent peptidase activity
HPY11_18575	COG4172	Belongs to the ABC transporter superfamily
HPY11_18595	COG0583	DNA-binding transcription factor activity
HPY11_18605	COG1620	l-lactate permease
HPY11_18620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY11_18630	COG0840	transmembrane signaling receptor activity
HPY11_18650	COG2258	MOSC domain
HPY11_18655	COG0513	Belongs to the DEAD box helicase family
HPY11_18665	COG2186	Transcriptional regulator
HPY11_18675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY11_18685	COG0246	Mannitol dehydrogenase
HPY11_18690	COG1904	glucuronate isomerase
HPY11_18695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_18700	COG0800	Aldolase
HPY11_18710	COG0583	DNA-binding transcription factor activity
HPY11_18720	COG1902	pentaerythritol trinitrate reductase activity
HPY11_18730	COG1132	(ABC) transporter
HPY11_18740	COG1902	pentaerythritol trinitrate reductase activity
HPY11_18750	COG1280	lysine exporter protein (LysE YggA)
HPY11_18755	COG2207	Transcriptional regulator
HPY11_18775	COG1846	Transcriptional regulator
HPY11_18780	COG1764	response to oxidative stress
HPY11_18785	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY11_18790	COG0697	spore germination
HPY11_18800	COG0700	Nucleoside recognition
HPY11_18805	COG3366	ferrous iron transmembrane transporter activity
HPY11_18810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY11_18820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY11_18825	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY11_18830	COG2259	Doxx family
HPY11_18855	COG0363	glucosamine-6-phosphate deaminase activity
HPY11_18870	COG4580	involved in the transport of maltose and maltodextrins
HPY11_18885	COG0840	transmembrane signaling receptor activity
HPY11_18895	COG0840	transmembrane signaling receptor activity
HPY11_18900	COG3706	GGDEF domain
HPY11_18910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY11_18915	COG1126	abc transporter atp-binding protein
HPY11_18925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_18930	COG4597	amino acid ABC transporter
HPY11_18935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY11_18940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_18940	COG2213	PTS system mannitol-specific
HPY11_18945	COG0246	Mannitol dehydrogenase
HPY11_18950	COG3722	fumarate hydratase activity
HPY11_18985	COG2910	NAD(P)H-binding
HPY11_18995	COG0840	transmembrane signaling receptor activity
HPY11_19000	COG4221	oxidoreductase activity
HPY11_19010	COG1901	pseudouridine methyltransferase
HPY11_19025	COG0531	amino acid
HPY11_19030	COG1982	Orn Lys Arg decarboxylase major
HPY11_19040	COG2197	response regulator
HPY11_19090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY11_19115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY11_19180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY11_19185	COG0840	transmembrane signaling receptor activity
HPY11_19190	COG0835	chemotaxis
HPY11_19195	COG0835	chemotaxis
HPY11_19200	COG2198	Histidine kinase
HPY11_19200	COG0643	Histidine kinase
HPY11_19220	COG0601	transmembrane transport
HPY11_19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_19230	COG4608	Belongs to the ABC transporter superfamily
HPY11_19235	COG1444	tRNA N-acetyltransferase activity
HPY11_19240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine