locus-tag	class	description
HPY04_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY04_00010	COG0592	DNA-directed DNA polymerase activity
HPY04_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY04_00020	COG0187	DNA topoisomerase II activity
HPY04_00075	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY04_00080	COG3977	Valine--pyruvate aminotransferase
HPY04_00085	COG0751	glycine-tRNA ligase activity
HPY04_00090	COG0752	glycyl-tRNA synthetase alpha subunit
HPY04_00095	COG2119	membrane
HPY04_00105	COG0425	Belongs to the sulfur carrier protein TusA family
HPY04_00115	COG0604	alcohol dehydrogenase
HPY04_00125	COG0129	dihydroxy-acid dehydratase activity
HPY04_00130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY04_00145	COG0606	chelatase, subunit chli
HPY04_00150	COG0204	Acyl-transferase
HPY04_00155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY04_00160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY04_00170	COG3084	Protein conserved in bacteria
HPY04_00180	COG4326	sporulation control protein
HPY04_00185	COG1272	protein, Hemolysin III
HPY04_00195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY04_00200	COG0569	domain protein
HPY04_00205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY04_00205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY04_00210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY04_00215	COG0242	peptide deformylase activity
HPY04_00220	COG1652	LysM domain
HPY04_00225	COG0758	DNA mediated transformation
HPY04_00230	COG2922	Belongs to the Smg family
HPY04_00235	COG0551	DNA topoisomerase type I activity
HPY04_00240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY04_00245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY04_00250	COG0009	L-threonylcarbamoyladenylate synthase
HPY04_00255	COG0408	coproporphyrinogen oxidase activity
HPY04_00260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY04_00270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY04_00310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY04_00315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY04_00325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY04_00330	COG2104	thiamine diphosphate biosynthetic process
HPY04_00335	COG2022	thiamine diphosphate biosynthetic process
HPY04_00340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY04_00345	COG0006	proline dipeptidase activity
HPY04_00345	COG0006	proline dipeptidase activity
HPY04_00365	COG1522	sequence-specific DNA binding
HPY04_00370	COG5001	Diguanylate cyclase
HPY04_00370	COG5002	protein histidine kinase activity
HPY04_00390	COG0589	response to stress
HPY04_00395	COG1528	Iron-storage protein
HPY04_00405	COG2081	HI0933 family
HPY04_00415	COG1322	Protein conserved in bacteria
HPY04_00420	COG2226	methyltransferase
HPY04_00435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY04_00440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY04_00445	COG0805	protein transport
HPY04_00450	COG1858	cytochrome C peroxidase
HPY04_00455	COG0534	Mate efflux family protein
HPY04_00465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY04_00470	COG2937	Belongs to the GPAT DAPAT family
HPY04_00475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY04_00480	COG3161	chorismate lyase activity
HPY04_00485	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY04_00490	COG0840	transmembrane signaling receptor activity
HPY04_00500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY04_00505	COG0084	hydrolase, TatD family'
HPY04_00520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY04_00520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY04_00540	COG3078	GTPase activator activity
HPY04_00555	COG3071	HemY protein
HPY04_00560	COG2959	enzyme of heme biosynthesis
HPY04_00565	COG1587	Uroporphyrinogen-III synthase
HPY04_00570	COG0181	hydroxymethylbilane synthase activity
HPY04_00580	COG1965	Belongs to the frataxin family
HPY04_00590	COG0019	diaminopimelate decarboxylase activity
HPY04_00595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY04_00605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY04_00610	COG1011	Hydrolase
HPY04_00615	COG2199	diguanylate cyclase activity
HPY04_00615	COG2200	EAL domain
HPY04_00615	COG3287	FIST C domain
HPY04_00630	COG0561	phosphatase activity
HPY04_00635	COG2267	carboxylic ester hydrolase activity
HPY04_00640	COG1280	lysine exporter protein (LysE YggA)
HPY04_00645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY04_00650	COG0783	Belongs to the Dps family
HPY04_00680	COG0742	ribosomal rna small subunit methyltransferase
HPY04_00685	COG0552	protein localization to endoplasmic reticulum
HPY04_00690	COG2884	Cell division ATP-binding protein ftsE
HPY04_00695	COG2177	Part of the ABC transporter FtsEX involved in
HPY04_00700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY04_00705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_00720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY04_00725	COG4206	TonB-dependent receptor
HPY04_00730	COG1404	Belongs to the peptidase S8 family
HPY04_00735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY04_00805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY04_00810	COG3300	MHYT domain
HPY04_00810	COG5001	Diguanylate cyclase
HPY04_00820	COG3852	Histidine kinase
HPY04_00830	COG0174	glutamine synthetase
HPY04_00850	COG1295	ribonuclease BN
HPY04_00855	COG1490	D-aminoacyl-tRNA deacylase activity
HPY04_00860	COG0456	acetyltransferase
HPY04_00870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY04_00875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY04_00880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY04_00885	COG3031	protein transport across the cell outer membrane
HPY04_00895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY04_00900	COG1459	type II secretion system
HPY04_00905	COG2165	general secretion pathway protein
HPY04_00910	COG2165	general secretion pathway protein
HPY04_00915	COG2165	general secretion pathway protein
HPY04_00920	COG4795	General secretion pathway protein
HPY04_00925	COG3156	type II secretion system protein K
HPY04_00930	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY04_00935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY04_00945	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY04_00950	COG0494	nUDIX hydrolase
HPY04_00960	COG1040	competence protein
HPY04_00970	COG0596	Alpha beta hydrolase
HPY04_00980	COG2183	response to ionizing radiation
HPY04_00985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY04_00990	COG2199	diguanylate cyclase activity
HPY04_00995	COG0745	RESPONSE REGULATOR receiver
HPY04_01005	COG2233	PERMEase
HPY04_01010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY04_01015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY04_01020	COG1758	RNA polymerase activity
HPY04_01025	COG0194	GDP metabolic process
HPY04_01030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY04_01035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY04_01055	COG4232	protein-disulfide reductase activity
HPY04_01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY04_01070	COG1027	Aspartate ammonia-lyase
HPY04_01075	COG3706	GGDEF domain
HPY04_01080	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY04_01085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY04_01095	COG2205	protein histidine kinase activity
HPY04_01100	COG0745	RESPONSE REGULATOR receiver
HPY04_01110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY04_01115	COG0205	6-phosphofructokinase activity
HPY04_01120	COG1494	fructose-1,6-bisphosphatase
HPY04_01125	COG3074	FtsZ-dependent cytokinesis
HPY04_01130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY04_01135	COG0460	homoserine dehydrogenase
HPY04_01135	COG0527	aspartate kinase activity
HPY04_01140	COG0626	cystathionine gamma-synthase activity
HPY04_01145	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY04_01150	COG0281	malic enzyme
HPY04_01155	COG0254	rRNA binding
HPY04_01160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY04_01165	COG1609	Transcriptional regulator
HPY04_01170	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY04_01175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY04_01180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY04_01185	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY04_01190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY04_01195	COG0534	Mate efflux family protein
HPY04_01200	COG0149	triose-phosphate isomerase activity
HPY04_01225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY04_01230	COG0459	protein refolding
HPY04_01235	COG3344	reverse transcriptase
HPY04_01250	COG1509	lysine 2,3-aminomutase activity
HPY04_01255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY04_01265	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY04_01270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY04_01275	COG1053	succinate dehydrogenase
HPY04_01280	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY04_01285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY04_01290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY04_01295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY04_01300	COG1045	serine acetyltransferase
HPY04_01310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY04_01315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY04_01320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY04_01325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY04_01330	COG0137	argininosuccinate synthase activity
HPY04_01335	COG0165	Argininosuccinate lyase
HPY04_01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_01350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY04_01350	COG0678	peroxiredoxin activity
HPY04_01360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY04_01390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY04_01395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY04_01405	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY04_01410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY04_01415	COG0546	phosphoglycolate phosphatase activity
HPY04_01420	COG0180	Tryptophanyl-tRNA synthetase
HPY04_01435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY04_01445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY04_01470	COG3954	Phosphoribulokinase
HPY04_01480	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY04_01490	COG0488	(ABC) transporter
HPY04_01495	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY04_01510	COG1047	Peptidyl-prolyl cis-trans
HPY04_01520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY04_01525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY04_01535	COG0557	exoribonuclease II activity
HPY04_01540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY04_01545	COG0051	transcription antitermination factor activity, RNA binding
HPY04_01550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY04_01555	COG0088	Forms part of the polypeptide exit tunnel
HPY04_01560	COG0089	rRNA binding
HPY04_01565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY04_01570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY04_01575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY04_01580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY04_01585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY04_01590	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY04_01595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY04_01600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY04_01605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY04_01610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY04_01615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY04_01620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY04_01630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY04_01635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY04_01640	COG1841	ribosomal large subunit assembly
HPY04_01650	COG0201	protein transport
HPY04_01655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY04_01660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY04_01665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY04_01670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY04_01675	COG0202	RNA polymerase activity
HPY04_01680	COG0203	ribosomal protein L17
HPY04_01690	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY04_01695	COG3266	domain, Protein
HPY04_01695	COG3061	Opacity-associated protein A
HPY04_01700	COG0697	spore germination
HPY04_01705	COG2153	protein acetylation
HPY04_01710	COG0513	Belongs to the DEAD box helicase family
HPY04_01720	COG0737	Belongs to the 5'-nucleotidase family
HPY04_01725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY04_01725	COG1648	precorrin-2 dehydrogenase activity
HPY04_01730	COG0175	sulfate reduction
HPY04_01735	COG2895	sulfate adenylyltransferase (ATP) activity
HPY04_01740	COG0529	Catalyzes the synthesis of activated sulfate
HPY04_01760	COG1136	(ABC) transporter
HPY04_01775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY04_01780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_01785	COG0729	surface antigen
HPY04_01795	COG2105	PFAM AIG2 family protein
HPY04_01800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY04_01810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY04_01815	COG0163	prenyltransferase activity
HPY04_01825	COG1178	ABC-type Fe3 transport system permease component
HPY04_01830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY04_01835	COG3028	Belongs to the UPF0307 family
HPY04_01840	COG0312	modulator of DNA gyrase
HPY04_01845	COG2239	Acts as a magnesium transporter
HPY04_01850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_01855	COG1660	Displays ATPase and GTPase activities
HPY04_01860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_01865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY04_01875	COG1137	ATPase activity
HPY04_01880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY04_01895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY04_01895	COG0517	IMP dehydrogenase activity
HPY04_01905	COG1127	ABC transporter
HPY04_01910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY04_01915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY04_01920	COG2854	intermembrane phospholipid transfer
HPY04_01930	COG5007	Belongs to the BolA IbaG family
HPY04_01935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY04_01945	COG0251	oxidation-reduction process
HPY04_01955	COG0540	Belongs to the ATCase OTCase family
HPY04_01965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY04_01975	COG0564	pseudouridine synthase activity
HPY04_01980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY04_01985	COG0525	valine-tRNA ligase activity
HPY04_01990	COG2927	DNA polymerase III (CHI subunit)
HPY04_01995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY04_02000	COG0795	lipopolysaccharide-transporting ATPase activity
HPY04_02005	COG0795	lipopolysaccharide-transporting ATPase activity
HPY04_02020	COG3437	response regulator, receiver
HPY04_02065	COG0066	3-isopropylmalate dehydratase activity
HPY04_02070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY04_02075	COG0473	3-isopropylmalate dehydrogenase activity
HPY04_02095	COG0583	DNA-binding transcription factor activity
HPY04_02100	COG1022	Amp-dependent synthetase and ligase
HPY04_02105	COG0028	Belongs to the TPP enzyme family
HPY04_02110	COG0440	acetolactate synthase activity
HPY04_02115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY04_02120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY04_02125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY04_02135	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY04_02140	COG3079	Belongs to the UPF0149 family
HPY04_02145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_02150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_02165	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY04_02175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY04_02180	COG1595	DNA-templated transcription, initiation
HPY04_02195	COG3086	response to oxidative stress
HPY04_02200	COG0481	GTPase activity
HPY04_02210	COG0571	ribonuclease III activity
HPY04_02215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY04_02220	COG1381	Involved in DNA repair and RecF pathway recombination
HPY04_02225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY04_02230	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY04_02245	COG5001	Diguanylate cyclase
HPY04_02255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY04_02260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY04_02265	COG3956	TIGRFAM MazG family protein
HPY04_02270	COG0504	CTP synthase activity
HPY04_02275	COG0148	phosphopyruvate hydratase activity
HPY04_02280	COG0617	tRNA 3'-terminal CCA addition
HPY04_02285	COG3267	Type II secretory pathway component ExeA
HPY04_02285	COG3409	Peptidoglycan-binding domain 1 protein
HPY04_02295	COG4991	sh3 domain protein
HPY04_02300	COG0306	phosphate transporter
HPY04_02305	COG1392	Phosphate transport regulator
HPY04_02310	COG3025	triphosphatase activity
HPY04_02315	COG0840	transmembrane signaling receptor activity
HPY04_02320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY04_02325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY04_02325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY04_02330	COG1538	Outer membrane efflux protein
HPY04_02335	COG0494	nUDIX hydrolase
HPY04_02340	COG3151	Protein conserved in bacteria
HPY04_02350	COG3150	esterase
HPY04_02355	COG0187	DNA topoisomerase II activity
HPY04_02360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY04_02370	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY04_02375	COG0237	dephospho-CoA kinase activity
HPY04_02385	COG1459	type II secretion system
HPY04_02390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY04_02410	COG0716	FMN binding
HPY04_02415	COG4974	Belongs to the 'phage' integrase family
HPY04_02420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY04_02425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY04_02430	COG0737	Belongs to the 5'-nucleotidase family
HPY04_02435	COG2186	Transcriptional regulator
HPY04_02440	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY04_02445	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY04_02450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_02465	COG3116	cell division
HPY04_02470	COG0768	penicillin binding
HPY04_02475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY04_02480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY04_02490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY04_02495	COG0772	Belongs to the SEDS family
HPY04_02500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY04_02505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY04_02510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY04_02515	COG0849	cell division
HPY04_02520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY04_02525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY04_02535	COG0653	protein targeting
HPY04_02540	COG0494	nUDIX hydrolase
HPY04_02545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY04_02555	COG0505	Belongs to the CarA family
HPY04_02560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY04_02585	COG0730	response to heat
HPY04_02590	COG0583	DNA-binding transcription factor activity
HPY04_02595	COG2860	membrane
HPY04_02600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY04_02610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY04_02620	COG0493	'glutamate synthase
HPY04_02625	COG0070	glutamate synthase
HPY04_02625	COG0069	glutamate synthase activity
HPY04_02625	COG0067	glutamate synthase
HPY04_02635	COG0070	glutamate synthase
HPY04_02635	COG0067	glutamate synthase
HPY04_02635	COG0069	glutamate synthase activity
HPY04_02640	COG1242	4 iron, 4 sulfur cluster binding
HPY04_02645	COG4251	negative regulation of phosphorylation
HPY04_02645	COG5001	Diguanylate cyclase
HPY04_02645	COG2203	Gaf domain
HPY04_02645	COG3706	GGDEF domain
HPY04_02650	COG0784	Response regulator, receiver
HPY04_02650	COG5002	protein histidine kinase activity
HPY04_02650	COG2198	Histidine kinase
HPY04_02655	COG0745	RESPONSE REGULATOR receiver
HPY04_02665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY04_02685	COG0083	homoserine kinase activity
HPY04_02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY04_02695	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY04_02700	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY04_02705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY04_02720	COG1115	amino acid carrier protein
HPY04_02725	COG3022	response to hydroperoxide
HPY04_02735	COG0084	hydrolase, TatD family'
HPY04_02740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY04_02750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY04_02755	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY04_02760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY04_02765	COG0813	purine-nucleoside phosphorylase activity
HPY04_02775	COG0560	Phosphoserine phosphatase
HPY04_02785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY04_02790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY04_02795	COG1022	Amp-dependent synthetase and ligase
HPY04_02810	COG3250	beta-galactosidase activity
HPY04_02820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_02835	COG0569	domain protein
HPY04_02835	COG0189	ligase activity
HPY04_02840	COG0456	acetyltransferase
HPY04_02850	COG2171	N-acyltransferase activity
HPY04_02855	COG3141	response to X-ray
HPY04_02870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY04_02875	COG1074	ATP-dependent DNA helicase activity
HPY04_02880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY04_02890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY04_02890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY04_02900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY04_02905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY04_02910	COG2166	iron-sulfur cluster assembly
HPY04_02920	COG0693	protein deglycase activity
HPY04_02925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY04_02930	COG3248	Nucleoside-binding outer membrane protein
HPY04_02940	COG1595	DNA-templated transcription, initiation
HPY04_02950	COG2211	Major facilitator Superfamily
HPY04_02955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY04_02965	COG2813	Specifically methylates the guanine in position
HPY04_02970	COG0271	Belongs to the BolA IbaG family
HPY04_02975	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_02980	COG1805	sodium ion transport
HPY04_02985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_02990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_02995	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_03000	COG2871	sodium ion transport
HPY04_03005	COG1477	protein flavinylation
HPY04_03025	COG3706	GGDEF domain
HPY04_03030	COG0733	neurotransmitter:sodium symporter activity
HPY04_03040	COG0189	ligase activity
HPY04_03045	COG0189	ligase activity
HPY04_03045	COG4067	protein conserved in archaea
HPY04_03050	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY04_03055	COG2252	PERMEase
HPY04_03060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY04_03075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY04_03080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY04_03085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY04_03090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY04_03090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY04_03105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY04_03110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY04_03115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY04_03120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY04_03130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY04_03135	COG0024	Methionine aminopeptidase
HPY04_03140	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY04_03145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY04_03150	COG0528	UMP kinase activity
HPY04_03155	COG0233	cytoplasmic translational termination
HPY04_03160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY04_03165	COG0575	Belongs to the CDS family
HPY04_03170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY04_03175	COG0750	zinc metalloprotease
HPY04_03185	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY04_03190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_03195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY04_03200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_03205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_03210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY04_03215	COG0587	DNA-directed DNA polymerase activity
HPY04_03220	COG0825	malonyl-CoA metabolic process
HPY04_03225	COG0037	tRNA processing
HPY04_03235	COG3479	Phenolic acid decarboxylase
HPY04_03240	COG0347	Belongs to the P(II) protein family
HPY04_03245	COG3021	interspecies interaction between organisms
HPY04_03250	COG1388	LysM domain
HPY04_03250	COG0741	lytic transglycosylase activity
HPY04_03255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY04_03260	COG2226	methyltransferase
HPY04_03265	COG0328	RNA-DNA hybrid ribonuclease activity
HPY04_03280	COG1960	acyl-CoA dehydrogenase activity
HPY04_03285	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY04_03290	COG0121	glutamine amidotransferase
HPY04_03295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY04_03300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY04_03305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY04_03310	COG3706	GGDEF domain
HPY04_03315	COG1187	pseudouridine synthase activity
HPY04_03320	COG2840	Smr protein MutS2
HPY04_03350	COG2217	Heavy metal translocating P-type atpase
HPY04_03350	COG2608	mercury ion transmembrane transporter activity
HPY04_03355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY04_03370	COG1629	transport
HPY04_03370	COG4774	siderophore transport
HPY04_03375	COG2375	cellular response to nickel ion
HPY04_03380	COG3433	isochorismatase activity
HPY04_03380	COG2226	methyltransferase
HPY04_03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY04_03415	COG0835	chemotaxis
HPY04_03415	COG0784	Response regulator, receiver
HPY04_03420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY04_03425	COG1815	bacterial-type flagellum-dependent cell motility
HPY04_03440	COG1749	Flagellar hook protein flgE
HPY04_03445	COG4787	bacterial-type flagellum-dependent cell motility
HPY04_03455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY04_03460	COG1706	bacterial-type flagellum-dependent cell motility
HPY04_03465	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY04_03465	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY04_03480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_03485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_03570	COG0012	GTP binding
HPY04_03575	COG0193	aminoacyl-tRNA hydrolase activity
HPY04_03580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY04_03585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY04_03590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY04_03595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY04_03600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY04_03605	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY04_03615	COG2912	Transglutaminase-like superfamily
HPY04_03620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY04_03625	COG0737	Belongs to the 5'-nucleotidase family
HPY04_03630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY04_03635	COG2233	PERMEase
HPY04_03655	COG1393	Belongs to the ArsC family
HPY04_03660	COG4783	chaperone-mediated protein folding
HPY04_03680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY04_03695	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY04_03705	COG1876	peptidase activity
HPY04_03715	COG1393	Belongs to the ArsC family
HPY04_03735	COG2837	iron assimilation
HPY04_03740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_03745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_03750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_03755	COG1334	flagellar protein FlaG
HPY04_03760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY04_03770	COG1516	flagellar protein fliS
HPY04_03780	COG4191	Histidine kinase
HPY04_03790	COG1677	Flagellar hook-basal body complex protein FliE
HPY04_03800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY04_03805	COG1317	bacterial-type flagellum organization
HPY04_03830	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY04_03855	COG1987	bacterial-type flagellum assembly
HPY04_03860	COG1684	flagellar biosynthetic protein fliR
HPY04_03870	COG2840	Smr protein MutS2
HPY04_03875	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY04_03880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY04_03885	COG2860	membrane
HPY04_03890	COG3101	peptidyl-lysine hydroxylation
HPY04_03900	COG0431	NADPH-dependent FMN reductase
HPY04_03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY04_03905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY04_03910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY04_03915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY04_03920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY04_03925	COG0735	belongs to the Fur family
HPY04_03935	COG0583	DNA-binding transcription factor activity
HPY04_03945	COG1346	cytolysis
HPY04_03960	COG0596	Alpha beta hydrolase
HPY04_03965	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY04_03970	COG0033	Phosphoglucomutase
HPY04_03980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY04_03985	COG0372	Belongs to the citrate synthase family
HPY04_03990	COG2009	succinate dehydrogenase
HPY04_03995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY04_04000	COG1053	succinate dehydrogenase
HPY04_04010	COG0567	Dehydrogenase, E1 component
HPY04_04015	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY04_04020	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY04_04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY04_04035	COG1121	(ABC) transporter
HPY04_04040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY04_04045	COG4977	sequence-specific DNA binding
HPY04_04050	COG1918	ferrous iron import across plasma membrane
HPY04_04070	COG0018	arginyl-trna synthetase
HPY04_04080	COG1025	Belongs to the peptidase M16 family
HPY04_04085	COG2062	phosphohistidine phosphatase, SixA
HPY04_04115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY04_04120	COG0643	Histidine kinase
HPY04_04120	COG0784	Response regulator, receiver
HPY04_04120	COG2198	Histidine kinase
HPY04_04125	COG2201	protein-glutamate methylesterase activity
HPY04_04130	COG1192	Involved in chromosome partitioning
HPY04_04140	COG0835	chemotaxis
HPY04_04150	COG4133	protoheme IX ABC transporter activity
HPY04_04155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY04_04160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY04_04170	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY04_04175	COG1138	Cytochrome C-type biogenesis protein
HPY04_04180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY04_04185	COG3088	subunit of a heme lyase
HPY04_04185	COG4235	cytochrome complex assembly
HPY04_04195	COG2853	Lipoprotein
HPY04_04215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY04_04220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY04_04225	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY04_04240	COG3083	sulfuric ester hydrolase activity
HPY04_04245	COG3082	Protein of unknown function (DUF1414)
HPY04_04250	COG3081	Nucleoid-associated protein
HPY04_04260	COG1757	Na H antiporter
HPY04_04265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY04_04270	COG2095	MarC family integral membrane protein
HPY04_04275	COG1454	alcohol dehydrogenase
HPY04_04275	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_04285	COG0659	secondary active sulfate transmembrane transporter activity
HPY04_04290	COG1530	ribonuclease E activity
HPY04_04295	COG0564	pseudouridine synthase activity
HPY04_04300	COG0424	maF-like protein
HPY04_04305	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY04_04310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY04_04315	COG0416	fatty acid biosynthetic process
HPY04_04320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY04_04330	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_04335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY04_04340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY04_04345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY04_04350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY04_04355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY04_04365	COG0084	hydrolase, TatD family'
HPY04_04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_04370	COG1263	PTS System
HPY04_04385	COG0733	neurotransmitter:sodium symporter activity
HPY04_04400	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY04_04410	COG1940	carbohydrate kinase activity
HPY04_04415	COG0784	Response regulator, receiver
HPY04_04415	COG0835	chemotaxis
HPY04_04430	COG2226	methyltransferase
HPY04_04440	COG0676	glucose-6-phosphate 1-epimerase activity
HPY04_04445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY04_04450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_04460	COG3139	Protein of unknown function (DUF1315)
HPY04_04465	COG0252	asparaginase activity
HPY04_04470	COG0616	signal peptide processing
HPY04_04475	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY04_04475	COG1902	pentaerythritol trinitrate reductase activity
HPY04_04480	COG0788	formyltetrahydrofolate deformylase activity
HPY04_04490	COG1199	ATP-dependent helicase activity
HPY04_04495	COG1214	PFAM Peptidase M22, glycoprotease
HPY04_04510	COG0596	Alpha beta hydrolase
HPY04_04515	COG0318	PFAM AMP-dependent synthetase and ligase
HPY04_04520	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY04_04535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY04_04540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY04_04545	COG0436	Aminotransferase
HPY04_04550	COG1169	isochorismate synthase
HPY04_04555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY04_04560	COG0596	Alpha beta hydrolase
HPY04_04580	COG3135	benzoate transporter
HPY04_04585	COG0477	Major facilitator Superfamily
HPY04_04605	COG3015	lipoprotein NlpE involved in copper resistance
HPY04_04610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY04_04615	COG2894	cell division
HPY04_04620	COG0850	regulation of cytokinetic process
HPY04_04625	COG3100	YcgL domain-containing protein
HPY04_04630	COG2951	lytic endotransglycosylase activity
HPY04_04640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY04_04645	COG3325	Belongs to the glycosyl hydrolase 18 family
HPY04_04645	COG3469	chitinase activity
HPY04_04650	COG3005	denitrification pathway
HPY04_04655	COG0243	molybdopterin cofactor binding
HPY04_04670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_04680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY04_04715	COG4589	Belongs to the CDS family
HPY04_04725	COG3300	MHYT domain
HPY04_04725	COG5001	Diguanylate cyclase
HPY04_04735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY04_04740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY04_04745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY04_04750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY04_04760	COG4191	Histidine kinase
HPY04_04770	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY04_04780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY04_04785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY04_04790	COG0776	regulation of translation
HPY04_04795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY04_04800	COG1555	photosystem II stabilization
HPY04_04805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY04_04810	COG0539	negative regulation of cytoplasmic translation
HPY04_04815	COG0776	regulation of translation
HPY04_04820	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY04_04825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY04_04835	COG0601	transmembrane transport
HPY04_04840	COG4239	(ABC) transporter, permease
HPY04_04845	COG0747	negative chemotaxis
HPY04_04850	COG0444	Belongs to the ABC transporter superfamily
HPY04_04855	COG4608	Belongs to the ABC transporter superfamily
HPY04_04880	COG0583	DNA-binding transcription factor activity
HPY04_04890	COG0686	Belongs to the AlaDH PNT family
HPY04_04900	COG1674	ftsk spoiiie
HPY04_04905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY04_04910	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY04_04915	COG2186	Transcriptional regulator
HPY04_04930	COG0537	adenosine 5'-monophosphoramidase activity
HPY04_04955	COG3150	esterase
HPY04_04960	COG1252	NADH dehydrogenase
HPY04_04980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY04_04990	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY04_04995	COG1136	(ABC) transporter
HPY04_05000	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY04_05010	COG2333	competence protein COMEC
HPY04_05010	COG0658	competence protein
HPY04_05015	COG1132	(ABC) transporter
HPY04_05020	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY04_05025	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY04_05030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY04_05035	COG2719	SpoVR family
HPY04_05040	COG2718	Belongs to the UPF0229 family
HPY04_05045	COG2766	serine protein kinase
HPY04_05050	COG3013	Belongs to the UPF0304 family
HPY04_05060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY04_05065	COG0840	transmembrane signaling receptor activity
HPY04_05075	COG1882	Formate acetyltransferase
HPY04_05100	COG4160	amino acid transport
HPY04_05105	COG0708	Exodeoxyribonuclease III
HPY04_05110	COG0840	transmembrane signaling receptor activity
HPY04_05120	COG3923	Primosomal replication protein n
HPY04_05125	COG0730	response to heat
HPY04_05130	COG1199	ATP-dependent helicase activity
HPY04_05135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY04_05140	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY04_05145	COG3012	SEC-C Motif Domain Protein
HPY04_05150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY04_05155	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_05160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY04_05165	COG0215	cysteine-tRNA ligase activity
HPY04_05170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY04_05175	COG0632	four-way junction helicase activity
HPY04_05185	COG1271	oxidase subunit
HPY04_05190	COG1294	oxidase, subunit
HPY04_05195	COG4890	Cyd operon protein YbgT
HPY04_05200	COG3790	cyd operon protein YbgE
HPY04_05205	COG0824	Thioesterase
HPY04_05210	COG0811	peptide transport
HPY04_05225	COG0823	Involved in the tonB-independent uptake of proteins
HPY04_05230	COG2885	chlorophyll binding
HPY04_05240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY04_05250	COG0784	Response regulator, receiver
HPY04_05250	COG5002	protein histidine kinase activity
HPY04_05260	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_05265	COG3284	Transcriptional regulator
HPY04_05270	COG4628	conserved protein (DUF2132)
HPY04_05280	COG0415	Belongs to the DNA photolyase family
HPY04_05295	COG1401	restriction endodeoxyribonuclease activity
HPY04_05325	COG4409	exo-alpha-(2->6)-sialidase activity
HPY04_05330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY04_05335	COG1940	carbohydrate kinase activity
HPY04_05345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY04_05350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY04_05355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY04_05360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPY04_05365	COG1737	Transcriptional regulator
HPY04_05370	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY04_05375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY04_05385	COG4932	domain protein
HPY04_05385	COG5492	domain, Protein
HPY04_05410	COG0596	Alpha beta hydrolase
HPY04_05420	COG3064	Membrane
HPY04_05525	COG4789	Type iii secretion
HPY04_05530	COG4792	protein secretion
HPY04_05560	COG3710	Transcriptional regulator
HPY04_05570	COG4790	Type iii secretion
HPY04_05650	COG0582	viral genome integration into host DNA
HPY04_05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_05675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY04_05675	COG3008	intermembrane lipid transfer
HPY04_05680	COG2995	paraquat-inducible protein a
HPY04_05685	COG0668	transmembrane transport
HPY04_05705	COG1309	transcriptional regulator
HPY04_05710	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_05735	COG1960	acyl-CoA dehydrogenase activity
HPY04_05740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY04_05745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY04_05750	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY04_05755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY04_05770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY04_05775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY04_05780	COG0297	glycogen (starch) synthase activity
HPY04_05800	COG3070	regulator of competence-specific genes
HPY04_05805	COG1609	Transcriptional regulator
HPY04_05810	COG3381	protein complex oligomerization
HPY04_05815	COG0745	RESPONSE REGULATOR receiver
HPY04_05820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY04_05825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY04_05830	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY04_05835	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY04_05845	COG1979	alcohol dehydrogenase
HPY04_05850	COG2207	Transcriptional regulator
HPY04_05870	COG1032	radical SAM domain protein
HPY04_05875	COG5001	Diguanylate cyclase
HPY04_05880	COG0612	Peptidase, M16
HPY04_05895	COG0583	DNA-binding transcription factor activity
HPY04_05900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY04_05910	COG2350	Protein conserved in bacteria
HPY04_05915	COG1607	acyl-coa hydrolase
HPY04_05930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY04_05935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY04_05945	COG2116	formate transmembrane transporter activity
HPY04_05950	COG4459	periplasmic nitrate reductase
HPY04_05955	COG3005	denitrification pathway
HPY04_05960	COG0243	molybdopterin cofactor binding
HPY04_05975	COG1227	inorganic diphosphatase activity
HPY04_05990	COG4172	Belongs to the ABC transporter superfamily
HPY04_06005	COG4168	peptide transport system, permease
HPY04_06015	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY04_06020	COG1842	Phage shock protein A
HPY04_06035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_06050	COG2818	Glycosylase
HPY04_06055	COG0626	cystathionine gamma-synthase activity
HPY04_06065	COG0733	neurotransmitter:sodium symporter activity
HPY04_06070	COG0564	pseudouridine synthase activity
HPY04_06075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY04_06080	COG4136	ATPase activity
HPY04_06085	COG4135	transport system, permease component
HPY04_06090	COG4134	Bacterial extracellular solute-binding protein
HPY04_06100	COG3313	Fe-S protein
HPY04_06110	COG0842	Transport permease protein
HPY04_06115	COG1131	(ABC) transporter
HPY04_06120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_06125	COG0814	amino acid
HPY04_06135	COG2239	Acts as a magnesium transporter
HPY04_06140	COG2205	protein histidine kinase activity
HPY04_06140	COG0784	Response regulator, receiver
HPY04_06155	COG4934	collagen metabolic process
HPY04_06190	COG0840	transmembrane signaling receptor activity
HPY04_06200	COG5001	Diguanylate cyclase
HPY04_06200	COG4251	negative regulation of phosphorylation
HPY04_06200	COG3706	GGDEF domain
HPY04_06200	COG2203	Gaf domain
HPY04_06205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY04_06210	COG5002	protein histidine kinase activity
HPY04_06225	COG1061	Type III restriction enzyme res subunit
HPY04_06230	COG1187	pseudouridine synthase activity
HPY04_06235	COG2814	Major facilitator Superfamily
HPY04_06245	COG0702	epimerase
HPY04_06250	COG0534	Mate efflux family protein
HPY04_06255	COG4181	ATPase activity
HPY04_06270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY04_06280	COG1748	Saccharopine dehydrogenase
HPY04_06295	COG1538	Outer membrane efflux protein
HPY04_06315	COG0583	DNA-binding transcription factor activity
HPY04_06325	COG1451	nucleotide metabolic process
HPY04_06340	COG3063	Type IV pilus biogenesis stability protein PilW
HPY04_06345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY04_06365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_06380	COG3290	protein histidine kinase activity
HPY04_06385	COG4565	transcriptional regulatory protein
HPY04_06395	COG0835	chemotaxis
HPY04_06395	COG0784	Response regulator, receiver
HPY04_06440	COG1085	galactose-1-phosphate uridylyltransferase
HPY04_06445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY04_06450	COG2017	converts alpha-aldose to the beta-anomer
HPY04_06455	COG3706	GGDEF domain
HPY04_06460	COG2199	diguanylate cyclase activity
HPY04_06460	COG2200	EAL domain
HPY04_06465	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_06475	COG3527	Alpha-acetolactate decarboxylase
HPY04_06490	COG0753	catalase activity
HPY04_06510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY04_06560	COG1271	oxidase subunit
HPY04_06565	COG1294	oxidase, subunit
HPY04_06570	COG1136	(ABC) transporter
HPY04_06570	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY04_06575	COG1136	(ABC) transporter
HPY04_06575	COG0577	efflux transmembrane transporter activity
HPY04_06580	COG1136	(ABC) transporter
HPY04_06580	COG0577	efflux transmembrane transporter activity
HPY04_06605	COG2723	6-phospho-beta-galactosidase activity
HPY04_06610	COG1609	Transcriptional regulator
HPY04_06615	COG0251	oxidation-reduction process
HPY04_06620	COG2731	YhcH YjgK YiaL family protein
HPY04_06625	COG0584	glycerophosphoryl diester phosphodiesterase
HPY04_06630	COG1349	DNA-binding transcription factor activity
HPY04_06635	COG3842	ATPase activity
HPY04_06640	COG0395	ABC-type sugar transport system, permease component
HPY04_06645	COG1175	transmembrane transport
HPY04_06660	COG0811	peptide transport
HPY04_06665	COG0811	peptide transport
HPY04_06670	COG0848	biopolymer transport protein
HPY04_06675	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY04_06685	COG1793	dna ligase
HPY04_06695	COG0534	Mate efflux family protein
HPY04_06705	COG3001	Fructosamine kinase
HPY04_06715	COG0791	NLP P60 protein
HPY04_06720	COG0840	transmembrane signaling receptor activity
HPY04_06735	COG1940	carbohydrate kinase activity
HPY04_06750	COG0746	molybdenum cofactor guanylyltransferase activity
HPY04_06755	COG3842	ATPase activity
HPY04_06760	COG4662	Binding-protein-dependent transport system inner membrane component
HPY04_06770	COG2204	response regulator
HPY04_06775	COG3852	Histidine kinase
HPY04_06780	COG0488	(ABC) transporter
HPY04_06785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY04_06815	COG3383	formate dehydrogenase (NAD+) activity
HPY04_06815	COG0243	molybdopterin cofactor binding
HPY04_06820	COG0437	4 iron, 4 sulfur cluster binding
HPY04_06835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY04_06840	COG1666	GTP binding
HPY04_06845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY04_06860	COG2996	Protein conserved in bacteria
HPY04_06870	COG3008	intermembrane lipid transfer
HPY04_06875	COG2995	paraquat-inducible protein a
HPY04_06880	COG1132	(ABC) transporter
HPY04_06885	COG1956	GAF domain-containing protein
HPY04_06890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY04_06905	COG0308	aminopeptidase N
HPY04_06920	COG0167	dihydroorotate dehydrogenase activity
HPY04_06930	COG0116	Belongs to the methyltransferase superfamily
HPY04_06930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY04_06955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY04_06960	COG1067	ATP-dependent peptidase activity
HPY04_06965	COG3120	sequence-specific DNA binding
HPY04_07060	COG1073	alpha beta
HPY04_07060	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY04_07060	COG3064	Membrane
HPY04_07065	COG2994	toxin metabolic process
HPY04_07090	COG2205	protein histidine kinase activity
HPY04_07090	COG0784	Response regulator, receiver
HPY04_07105	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY04_07120	COG2010	Cytochrome c
HPY04_07130	COG2217	Heavy metal translocating P-type atpase
HPY04_07145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY04_07150	COG0589	response to stress
HPY04_07155	COG0037	tRNA processing
HPY04_07175	COG3842	ATPase activity
HPY04_07185	COG1177	transmembrane transport
HPY04_07195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY04_07210	COG1115	amino acid carrier protein
HPY04_07215	COG1280	lysine exporter protein (LysE YggA)
HPY04_07260	COG3501	Rhs element vgr protein
HPY04_07270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY04_07275	COG0840	transmembrane signaling receptor activity
HPY04_07280	COG2814	Major facilitator Superfamily
HPY04_07285	COG1566	PFAM secretion protein HlyD family protein
HPY04_07290	COG1538	Outer membrane efflux protein
HPY04_07305	COG0513	Belongs to the DEAD box helicase family
HPY04_07325	COG3290	protein histidine kinase activity
HPY04_07325	COG0840	transmembrane signaling receptor activity
HPY04_07330	COG0835	chemotaxis
HPY04_07335	COG2201	protein-glutamate methylesterase activity
HPY04_07345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY04_07350	COG0784	Response regulator, receiver
HPY04_07350	COG2198	Histidine kinase
HPY04_07350	COG0643	Histidine kinase
HPY04_07355	COG2198	Histidine kinase
HPY04_07355	COG0643	Histidine kinase
HPY04_07365	COG0745	RESPONSE REGULATOR receiver
HPY04_07380	COG0415	Belongs to the DNA photolyase family
HPY04_07385	COG0477	Major facilitator Superfamily
HPY04_07390	COG0583	DNA-binding transcription factor activity
HPY04_07400	COG0402	S-adenosylhomocysteine deaminase activity
HPY04_07405	COG0095	Lipoate-protein ligase
HPY04_07410	COG0443	Heat shock 70 kDa protein
HPY04_07420	COG1643	Atp-dependent helicase
HPY04_07450	COG0443	Heat shock 70 kDa protein
HPY04_07455	COG0443	Heat shock 70 kDa protein
HPY04_07460	COG3706	GGDEF domain
HPY04_07490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY04_07495	COG0602	queuosine metabolic process
HPY04_07500	COG0561	phosphatase activity
HPY04_07510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_07515	COG4597	amino acid ABC transporter
HPY04_07520	COG0765	amino acid transport
HPY04_07525	COG1126	abc transporter atp-binding protein
HPY04_07530	COG0670	Belongs to the BI1 family
HPY04_07535	COG2920	part of a sulfur-relay system
HPY04_07540	COG1254	Belongs to the acylphosphatase family
HPY04_07545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY04_07550	COG3706	GGDEF domain
HPY04_07560	COG2205	protein histidine kinase activity
HPY04_07560	COG3850	Histidine kinase
HPY04_07560	COG3437	response regulator, receiver
HPY04_07560	COG4999	Histidine kinase
HPY04_07565	COG3437	response regulator, receiver
HPY04_07570	COG0625	glutathione transferase activity
HPY04_07580	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY04_07590	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY04_07605	COG3385	transposase activity
HPY04_07625	COG0372	Belongs to the citrate synthase family
HPY04_07630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY04_07670	COG1129	ABC transporter
HPY04_07695	COG0745	RESPONSE REGULATOR receiver
HPY04_07700	COG5002	protein histidine kinase activity
HPY04_07705	COG3713	MltA-interacting MipA family protein
HPY04_07710	COG2990	Protein conserved in bacteria
HPY04_07720	COG4191	Histidine kinase
HPY04_07720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_07725	COG0471	metal ion transport
HPY04_07735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY04_07750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_07760	COG3768	UPF0283 membrane protein
HPY04_07765	COG3106	COG3106 Predicted ATPase
HPY04_07780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY04_07785	COG0494	nUDIX hydrolase
HPY04_07790	COG0814	amino acid
HPY04_07795	COG1760	l-serine dehydratase
HPY04_07800	COG0720	synthase
HPY04_07805	COG0840	transmembrane signaling receptor activity
HPY04_07810	COG0017	Asparaginyl-tRNA synthetase
HPY04_07815	COG0351	phosphomethylpyrimidine kinase
HPY04_07820	COG3437	response regulator, receiver
HPY04_07820	COG2770	Histidine kinase
HPY04_07825	COG1448	Aminotransferase
HPY04_07840	COG0840	transmembrane signaling receptor activity
HPY04_07845	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY04_07850	COG2943	transferase activity, transferring hexosyl groups
HPY04_07855	COG1609	Transcriptional regulator
HPY04_07860	COG3394	polysaccharide catabolic process
HPY04_07865	COG1486	melibiose metabolic process
HPY04_07870	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPY04_07880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPY04_07885	COG0726	polysaccharide deacetylase
HPY04_07890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY04_07895	COG1846	Transcriptional regulator
HPY04_07920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY04_07935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY04_07940	COG3108	Peptidase M15
HPY04_07970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY04_07980	COG2814	Major facilitator Superfamily
HPY04_08000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY04_08005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY04_08010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY04_08055	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY04_08060	COG4139	cobalamin transport
HPY04_08065	COG2988	succinylglutamate desuccinylase activity
HPY04_08080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY04_08085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY04_08090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_08100	COG2925	Exonuclease
HPY04_08105	COG1380	Effector of murein hydrolase LrgA
HPY04_08110	COG1346	cytolysis
HPY04_08140	COG0776	regulation of translation
HPY04_08145	COG0072	phenylalanine-tRNA ligase activity
HPY04_08145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_08150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY04_08190	COG0322	excinuclease ABC activity
HPY04_08195	COG2197	response regulator
HPY04_08200	COG0417	DNA replication proofreading
HPY04_08205	COG5001	Diguanylate cyclase
HPY04_08215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY04_08220	COG3099	Belongs to the UPF0263 family
HPY04_08235	COG1228	amidohydrolase
HPY04_08240	COG0010	Belongs to the arginase family
HPY04_08245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY04_08250	COG2986	histidine ammonia-lyase
HPY04_08270	COG0277	FAD linked oxidase domain protein
HPY04_08270	COG0247	lactate metabolic process
HPY04_08285	COG2885	chlorophyll binding
HPY04_08305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY04_08315	COG0281	malic enzyme
HPY04_08325	COG2949	membrane
HPY04_08330	COG3706	GGDEF domain
HPY04_08335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY04_08345	COG0492	ferredoxin-NADP+ reductase activity
HPY04_08350	COG4988	ABC transporter
HPY04_08355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY04_08360	COG1187	pseudouridine synthase activity
HPY04_08365	COG0009	L-threonylcarbamoyladenylate synthase
HPY04_08370	COG0613	PHP domain protein
HPY04_08380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY04_08385	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY04_08390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY04_08395	COG0135	phosphoribosylanthranilate isomerase activity
HPY04_08395	COG0134	indole-3-glycerol-phosphate synthase activity
HPY04_08400	COG0133	tryptophan synthase activity
HPY04_08405	COG0159	tryptophan synthase activity
HPY04_08415	COG1435	thymidine kinase activity
HPY04_08420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY04_08425	COG1801	Protein of unknown function DUF72
HPY04_08430	COG4106	trans-aconitate 2-methyltransferase activity
HPY04_08435	COG0500	methyltransferase
HPY04_08440	COG0189	ligase activity
HPY04_08440	COG4067	protein conserved in archaea
HPY04_08455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY04_08465	COG3852	Histidine kinase
HPY04_08480	COG3070	regulator of competence-specific genes
HPY04_08490	COG2431	L-lysine efflux transmembrane transporter activity
HPY04_08500	COG0076	glutamate decarboxylase activity
HPY04_08505	COG1737	Transcriptional regulator
HPY04_08510	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_08510	COG1454	alcohol dehydrogenase
HPY04_08515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY04_08520	COG2985	domain, Protein
HPY04_08520	COG3273	potassium ion transport
HPY04_08525	COG0542	response to heat
HPY04_08530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY04_08535	COG1278	Cold shock
HPY04_08545	COG1187	pseudouridine synthase activity
HPY04_08550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY04_08550	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY04_08555	COG0107	imidazoleglycerol-phosphate synthase activity
HPY04_08560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY04_08565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY04_08570	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY04_08570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY04_08575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY04_08580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY04_08585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY04_08590	COG1757	Na H antiporter
HPY04_08595	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY04_08600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_08605	COG0482	sulfurtransferase activity
HPY04_08610	COG2915	High frequency lysogenization protein hflD homolog
HPY04_08615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY04_08625	COG2268	Band 7 protein
HPY04_08635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY04_08650	COG0300	oxidoreductase activity
HPY04_08660	COG0501	Belongs to the peptidase M48B family
HPY04_08670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY04_08675	COG2226	methyltransferase
HPY04_08680	COG0156	8-amino-7-oxononanoate synthase activity
HPY04_08685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY04_08690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY04_08695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY04_08700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY04_08705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY04_08710	COG0653	protein targeting
HPY04_08715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY04_08720	COG2203	Gaf domain
HPY04_08720	COG2199	diguanylate cyclase activity
HPY04_08730	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY04_08740	COG4628	conserved protein (DUF2132)
HPY04_08745	COG3092	negative regulation of chromosome organization
HPY04_08750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY04_08755	COG0857	belongs to the CobB CobQ family
HPY04_08755	COG0280	phosphate acetyltransferase
HPY04_08760	COG0435	Glutathione S-transferase
HPY04_08765	COG4608	Belongs to the ABC transporter superfamily
HPY04_08770	COG0444	Belongs to the ABC transporter superfamily
HPY04_08775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_08780	COG0601	transmembrane transport
HPY04_08800	COG2204	response regulator
HPY04_08805	COG5001	Diguanylate cyclase
HPY04_08805	COG3300	MHYT domain
HPY04_08810	COG4191	Histidine kinase
HPY04_08815	COG5002	protein histidine kinase activity
HPY04_08825	COG2201	protein-glutamate methylesterase activity
HPY04_08840	COG0009	L-threonylcarbamoyladenylate synthase
HPY04_08855	COG1881	PFAM PEBP family protein
HPY04_08880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY04_08885	COG0640	Transcriptional regulator
HPY04_08895	COG0454	-acetyltransferase
HPY04_08905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY04_08910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_08920	COG5002	protein histidine kinase activity
HPY04_08930	COG3706	GGDEF domain
HPY04_08950	COG1946	Acyl-CoA thioesterase
HPY04_08955	COG1522	sequence-specific DNA binding
HPY04_08965	COG0616	signal peptide processing
HPY04_08970	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_08975	COG2983	Belongs to the UPF0260 family
HPY04_08985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY04_08990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY04_08995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY04_09000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY04_09005	COG2832	Protein of unknown function (DUF454)
HPY04_09010	COG0745	RESPONSE REGULATOR receiver
HPY04_09015	COG0583	DNA-binding transcription factor activity
HPY04_09020	COG0778	Nitroreductase
HPY04_09025	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY04_09025	COG1024	Enoyl-CoA hydratase
HPY04_09030	COG0183	Belongs to the thiolase family
HPY04_09045	COG2067	long-chain fatty acid transport protein
HPY04_09055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY04_09060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY04_09065	COG2982	Protein involved in outer membrane biogenesis
HPY04_09070	COG0572	uridine kinase
HPY04_09075	COG0489	protein tyrosine kinase activity
HPY04_09080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_09080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_09090	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY04_09100	COG0517	IMP dehydrogenase activity
HPY04_09100	COG0617	tRNA 3'-terminal CCA addition
HPY04_09100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY04_09105	COG2199	diguanylate cyclase activity
HPY04_09110	COG0314	molybdopterin synthase activity
HPY04_09115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY04_09120	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY04_09125	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY04_09130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY04_09135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY04_09140	COG2198	Histidine kinase
HPY04_09145	COG2204	response regulator
HPY04_09150	COG0556	nucleotide-excision repair
HPY04_09160	COG4657	Part of a membrane complex involved in electron transport
HPY04_09165	COG2878	Part of a membrane complex involved in electron transport
HPY04_09170	COG4656	Part of a membrane complex involved in electron transport
HPY04_09185	COG4660	Part of a membrane complex involved in electron transport
HPY04_09190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY04_09195	COG0346	lactoylglutathione lyase activity
HPY04_09210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY04_09215	COG2056	Na+-H+ antiporter family
HPY04_09220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY04_09225	COG1286	toxin biosynthetic process
HPY04_09230	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY04_09235	COG0285	dihydrofolate synthase activity
HPY04_09240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY04_09245	COG0101	tRNA pseudouridine synthase activity
HPY04_09260	COG1263	PTS System
HPY04_09260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_09260	COG2190	(PTS) system
HPY04_09265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY04_09270	COG1846	Transcriptional regulator
HPY04_09270	COG1940	carbohydrate kinase activity
HPY04_09275	COG4651	solute:proton antiporter activity
HPY04_09275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY04_09280	COG0367	asparagine synthase
HPY04_09290	COG3104	oligopeptide transport
HPY04_09295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY04_09300	COG0563	adenylate kinase activity
HPY04_09305	COG0326	Molecular chaperone. Has ATPase activity
HPY04_09310	COG3710	Transcriptional regulator
HPY04_09325	COG0622	Phosphoesterase
HPY04_09330	COG1090	epimerase
HPY04_09335	COG0300	oxidoreductase activity
HPY04_09340	COG3118	belongs to the thioredoxin family
HPY04_09345	COG0330	HflC and HflK could
HPY04_09350	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY04_09355	COG0789	Transcriptional regulator
HPY04_09360	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY04_09370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY04_09375	COG3115	cell septum assembly
HPY04_09380	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY04_09385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY04_09390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_09400	COG2190	(PTS) system
HPY04_09405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_09410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY04_09415	COG1702	phosphate starvation-inducible protein PhoH
HPY04_09420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY04_09425	COG4535	Mg2 and Co2 transporter CorC
HPY04_09430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY04_09435	COG2888	peptidyl-tyrosine sulfation
HPY04_09440	COG0495	leucyl-tRNA aminoacylation
HPY04_09445	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY04_09450	COG1466	dna polymerase III delta subunit
HPY04_09455	COG0799	negative regulation of ribosome biogenesis
HPY04_09460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY04_09465	COG0768	penicillin binding
HPY04_09470	COG0772	Belongs to the SEDS family
HPY04_09475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY04_09480	COG1686	Belongs to the peptidase S11 family
HPY04_09485	COG2921	Belongs to the UPF0250 family
HPY04_09490	COG0321	lipoyl(octanoyl) transferase activity
HPY04_09495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY04_09505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY04_09530	COG1596	polysaccharide export
HPY04_09540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY04_09570	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY04_09580	COG0438	transferase activity, transferring glycosyl groups
HPY04_09590	COG0297	glycogen (starch) synthase activity
HPY04_09610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY04_09615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY04_09620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY04_09625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY04_09655	COG0366	Alpha amylase catalytic
HPY04_09660	COG1263	PTS System
HPY04_09660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_09665	COG1609	Transcriptional regulator
HPY04_09670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY04_09675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY04_09680	COG2011	ABC-type metal ion transport system permease component
HPY04_09685	COG1464	Belongs to the NlpA lipoprotein family
HPY04_09690	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY04_09700	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY04_09700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY04_09710	COG3706	GGDEF domain
HPY04_09715	COG1611	Belongs to the LOG family
HPY04_09720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY04_09725	COG2363	Small membrane protein
HPY04_09730	COG0583	DNA-binding transcription factor activity
HPY04_09735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY04_09735	COG0301	tRNA thio-modification
HPY04_09745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY04_09750	COG1722	exodeoxyribonuclease VII activity
HPY04_09755	COG0142	geranyltranstransferase activity
HPY04_09760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY04_09765	COG0564	pseudouridine synthase activity
HPY04_09770	COG3098	single-species biofilm formation
HPY04_09785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_09795	COG1671	Belongs to the UPF0178 family
HPY04_09800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY04_09805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY04_09810	COG0254	rRNA binding
HPY04_09815	COG1720	tRNA m6t6A37 methyltransferase activity
HPY04_09820	COG0442	prolyl-tRNA aminoacylation
HPY04_09850	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY04_09850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY04_09855	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY04_09865	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY04_09895	COG0484	heat shock protein binding
HPY04_09900	COG0443	Heat shock 70 kDa protein
HPY04_09905	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY04_09910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY04_09915	COG0497	DNA recombination
HPY04_09920	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_09925	COG2914	Belongs to the UPF0125 (RnfH) family
HPY04_09930	COG2867	negative regulation of translational initiation
HPY04_09935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY04_09945	COG0582	viral genome integration into host DNA
HPY04_09995	COG0732	type I restriction modification DNA specificity domain
HPY04_10035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY04_10100	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY04_10105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY04_10110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY04_10130	COG3051	citrate lyase alpha subunit
HPY04_10135	COG2301	Belongs to the HpcH HpaI aldolase family
HPY04_10140	COG3052	prosthetic group binding
HPY04_10145	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY04_10155	COG3630	sodium ion export across plasma membrane
HPY04_10160	COG0511	ligase activity, forming carbon-carbon bonds
HPY04_10160	COG5016	pyruvate
HPY04_10165	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY04_10175	COG4565	transcriptional regulatory protein
HPY04_10190	COG0583	DNA-binding transcription factor activity
HPY04_10200	COG1115	amino acid carrier protein
HPY04_10205	COG2977	Belongs to the P-Pant transferase superfamily
HPY04_10210	COG1120	ATPase activity
HPY04_10215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_10220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_10225	COG4592	Periplasmic binding protein
HPY04_10235	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_10240	COG1169	isochorismate synthase
HPY04_10245	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY04_10250	COG3433	isochorismatase activity
HPY04_10250	COG1535	isochorismatase
HPY04_10255	COG1584	GPR1 FUN34 yaaH family protein
HPY04_10265	COG0519	Catalyzes the synthesis of GMP from XMP
HPY04_10265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY04_10270	COG0516	GMP reductase activity
HPY04_10270	COG0517	IMP dehydrogenase activity
HPY04_10275	COG1570	exodeoxyribonuclease VII activity
HPY04_10290	COG1160	GTP binding
HPY04_10295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_10300	COG2976	Protein conserved in bacteria
HPY04_10305	COG0124	histidyl-tRNA synthetase
HPY04_10310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY04_10325	COG0105	UTP biosynthetic process
HPY04_10330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY04_10335	COG2975	iron-sulfur cluster assembly
HPY04_10340	COG0633	Ferredoxin
HPY04_10360	COG0822	iron-sulfur transferase activity
HPY04_10370	COG1959	2 iron, 2 sulfur cluster binding
HPY04_10380	COG0483	inositol monophosphate 1-phosphatase activity
HPY04_10385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_10390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_10395	COG1862	Preprotein translocase
HPY04_10410	COG0517	IMP dehydrogenase activity
HPY04_10420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY04_10425	COG0583	DNA-binding transcription factor activity
HPY04_10430	COG0450	alkyl hydroperoxide reductase
HPY04_10435	COG3142	Participates in the control of copper homeostasis
HPY04_10450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY04_10455	COG0581	inorganic phosphate transmembrane transporter activity
HPY04_10465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY04_10470	COG0248	Ppx GppA phosphatase
HPY04_10480	COG5002	protein histidine kinase activity
HPY04_10485	COG0745	RESPONSE REGULATOR receiver
HPY04_10500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY04_10545	COG0542	response to heat
HPY04_10555	COG0564	pseudouridine synthase activity
HPY04_10560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_10565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY04_10570	COG1605	Chorismate mutase
HPY04_10570	COG0077	Prephenate dehydratase
HPY04_10575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY04_10580	COG5001	Diguanylate cyclase
HPY04_10590	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY04_10600	COG0488	(ABC) transporter
HPY04_10610	COG1605	Chorismate mutase
HPY04_10610	COG0287	Prephenate dehydrogenase
HPY04_10615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY04_10620	COG3275	phosphorelay sensor kinase activity
HPY04_10625	COG3279	Response regulator of the LytR AlgR family
HPY04_10635	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY04_10640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY04_10650	COG1966	Carbon starvation protein
HPY04_10655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY04_10660	COG1047	Peptidyl-prolyl cis-trans
HPY04_10665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY04_10675	COG0196	riboflavin kinase activity
HPY04_10680	COG0728	peptidoglycan biosynthetic process
HPY04_10685	COG0268	Binds directly to 16S ribosomal RNA
HPY04_10690	COG0640	Transcriptional regulator
HPY04_10695	COG0583	DNA-binding transcription factor activity
HPY04_10700	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY04_10710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY04_10715	COG0730	response to heat
HPY04_10720	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY04_10725	COG0494	nUDIX hydrolase
HPY04_10730	COG3066	DNA modification
HPY04_10735	COG0667	Aldo Keto reductase
HPY04_10745	COG2204	response regulator
HPY04_10750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY04_10770	COG0513	Belongs to the DEAD box helicase family
HPY04_10795	COG3153	acetyltransferase
HPY04_10800	COG3154	lipid carrier protein
HPY04_10810	COG0826	peptidase U32
HPY04_10815	COG0826	peptidase U32
HPY04_10835	COG1185	polyribonucleotide nucleotidyltransferase activity
HPY04_10840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY04_10850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY04_10855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY04_10860	COG0195	Participates in both transcription termination and antitermination
HPY04_10865	COG0779	Required for maturation of 30S ribosomal subunits
HPY04_10880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY04_10890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY04_10895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY04_10900	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY04_10905	COG1534	Rna-binding protein
HPY04_10910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY04_10915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY04_10920	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY04_10925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY04_10930	COG0739	heme binding
HPY04_10945	COG0316	Belongs to the HesB IscA family
HPY04_10950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY04_10955	COG0628	permease
HPY04_10960	COG2813	Specifically methylates the guanine in position
HPY04_10965	COG2205	protein histidine kinase activity
HPY04_10965	COG0784	Response regulator, receiver
HPY04_10970	COG0747	negative chemotaxis
HPY04_10975	COG0601	transmembrane transport
HPY04_10980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_10985	COG0444	Belongs to the ABC transporter superfamily
HPY04_10990	COG4608	Belongs to the ABC transporter superfamily
HPY04_11000	COG2971	BadF BadG BcrA BcrD
HPY04_11020	COG3842	ATPase activity
HPY04_11030	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY04_11035	COG0004	ammonium transporteR
HPY04_11040	COG0347	Belongs to the P(II) protein family
HPY04_11045	COG3112	Uncharacterised protein family (UPF0231)
HPY04_11050	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY04_11055	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY04_11060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY04_11065	COG1643	Atp-dependent helicase
HPY04_11075	COG1489	DNA binding
HPY04_11085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY04_11095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY04_11100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY04_11105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY04_11110	COG0842	Transport permease protein
HPY04_11115	COG1131	(ABC) transporter
HPY04_11120	COG0659	secondary active sulfate transmembrane transporter activity
HPY04_11125	COG0288	reversible hydration of carbon dioxide
HPY04_11140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY04_11145	COG3107	peptidoglycan biosynthetic process
HPY04_11150	COG0792	nuclease activity
HPY04_11155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY04_11160	COG2823	Periplasmic or secreted lipoprotein
HPY04_11165	COG2969	positive regulation of protein catabolic process
HPY04_11170	COG0625	glutathione transferase activity
HPY04_11175	COG2857	Cytochrome c1
HPY04_11180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY04_11185	COG0723	plastoquinol--plastocyanin reductase activity
HPY04_11190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY04_11195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY04_11200	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY04_11210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY04_11215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY04_11220	COG0335	large ribosomal subunit rRNA binding
HPY04_11225	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY04_11230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY04_11235	COG0228	four-way junction DNA binding
HPY04_11240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY04_11245	COG4137	Cytochrome C assembly protein
HPY04_11250	COG4536	flavin adenine dinucleotide binding
HPY04_11255	COG1854	S-ribosylhomocysteine lyase activity
HPY04_11260	COG2918	glutathione biosynthetic process
HPY04_11265	COG0612	Peptidase, M16
HPY04_11270	COG1238	metal cluster binding
HPY04_11280	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY04_11285	COG0511	ligase activity, forming carbon-carbon bonds
HPY04_11285	COG5016	pyruvate
HPY04_11290	COG3630	sodium ion export across plasma membrane
HPY04_11335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY04_11340	COG0527	aspartate kinase activity
HPY04_11345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY04_11350	COG2137	regulation of response to DNA damage stimulus
HPY04_11355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY04_11365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY04_11370	COG4208	sulfate ABC transporter
HPY04_11390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY04_11395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY04_11405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY04_11410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY04_11415	COG0585	pseudouridine synthase activity
HPY04_11420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY04_11425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY04_11430	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY04_11435	COG1968	undecaprenyl-diphosphatase activity
HPY04_11440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY04_11445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY04_11450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY04_11460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY04_11465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY04_11470	COG1610	YqeY-like protein
HPY04_11475	COG0358	DNA primase activity
HPY04_11495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY04_11500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY04_11505	COG1349	DNA-binding transcription factor activity
HPY04_11525	COG1279	arginine transmembrane transporter activity
HPY04_11530	COG0668	transmembrane transport
HPY04_11535	COG0191	fructose-bisphosphate aldolase activity
HPY04_11540	COG0126	phosphoglycerate kinase activity
HPY04_11545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY04_11550	COG4771	TonB-dependent receptor
HPY04_11555	COG0583	DNA-binding transcription factor activity
HPY04_11560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY04_11565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY04_11575	COG2356	endonuclease I
HPY04_11580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY04_11585	COG0189	ligase activity
HPY04_11590	COG1678	Uncharacterized ACR, COG1678
HPY04_11595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY04_11600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY04_11620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY04_11625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY04_11630	COG0762	integral membrane protein
HPY04_11645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY04_11650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY04_11655	COG2066	Belongs to the glutaminase family
HPY04_11660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY04_11665	COG1194	a g-specific adenine glycosylase
HPY04_11670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY04_11675	COG0741	lytic transglycosylase activity
HPY04_11730	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY04_11735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY04_11740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY04_11745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY04_11750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY04_11755	COG2967	ApaG domain
HPY04_11760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY04_11770	COG3610	response to peptide
HPY04_11775	COG2966	Psort location CytoplasmicMembrane, score
HPY04_11780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY04_11785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY04_11790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY04_11795	COG0142	geranyltranstransferase activity
HPY04_11800	COG0531	amino acid
HPY04_11805	COG0039	L-malate dehydrogenase activity
HPY04_11810	COG1438	arginine binding
HPY04_11815	COG2358	TRAP transporter, solute receptor (TAXI family
HPY04_11825	COG0589	response to stress
HPY04_11845	COG2235	arginine
HPY04_11850	COG0312	modulator of DNA gyrase
HPY04_11855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY04_11860	COG3164	Protein of unknown function
HPY04_11865	COG1530	ribonuclease E activity
HPY04_11870	COG0424	maF-like protein
HPY04_11875	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY04_11880	COG1792	Involved in formation and maintenance of cell shape
HPY04_11885	COG1077	Cell shape determining protein MreB Mrl
HPY04_11930	COG1459	type II secretion system
HPY04_11935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY04_11945	COG3409	Peptidoglycan-binding domain 1 protein
HPY04_11945	COG3267	Type II secretory pathway component ExeA
HPY04_11970	COG2199	diguanylate cyclase activity
HPY04_11970	COG2200	EAL domain
HPY04_11980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY04_11985	COG0732	type I restriction modification DNA specificity domain
HPY04_12025	COG0629	single-stranded DNA binding
HPY04_12040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY04_12055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY04_12060	COG0527	aspartate kinase activity
HPY04_12065	COG0646	methionine synthase
HPY04_12065	COG1410	methionine synthase
HPY04_12130	COG0175	sulfate reduction
HPY04_12140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY04_12165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY04_12170	COG0735	belongs to the Fur family
HPY04_12185	COG0166	Belongs to the GPI family
HPY04_12195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY04_12210	COG0359	binds to the 23S rRNA
HPY04_12215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY04_12220	COG2965	DNA replication, synthesis of RNA primer
HPY04_12225	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY04_12235	COG2906	2 iron, 2 sulfur cluster binding
HPY04_12240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY04_12245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY04_12250	COG0049	tRNA binding
HPY04_12265	COG2923	Belongs to the DsrF TusC family
HPY04_12270	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY04_12275	COG2964	Protein conserved in bacteria
HPY04_12280	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY04_12290	COG2900	Belongs to the SlyX family
HPY04_12295	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY04_12300	COG0330	HflC and HflK could
HPY04_12305	COG0330	HflC and HflK could
HPY04_12310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY04_12315	COG1923	regulation of RNA biosynthetic process
HPY04_12320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY04_12325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY04_12335	COG0802	atpase or kinase
HPY04_12340	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY04_12390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY04_12395	COG1162	GTPase activity
HPY04_12400	COG0688	phosphatidylethanolamine metabolic process
HPY04_12405	COG0471	metal ion transport
HPY04_12415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY04_12420	COG4942	peptidase
HPY04_12435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY04_12440	COG2816	NAD+ diphosphatase activity
HPY04_12445	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY04_12450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY04_12455	COG0085	RNA polymerase activity
HPY04_12460	COG0222	ribosome binding
HPY04_12465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY04_12475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY04_12480	COG0250	Participates in transcription elongation, termination and antitermination
HPY04_12485	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY04_12490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY04_12515	COG1072	(Pantothenic acid kinase))
HPY04_12525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY04_12535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY04_12580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY04_12595	COG3118	belongs to the thioredoxin family
HPY04_12600	COG0513	Belongs to the DEAD box helicase family
HPY04_12610	COG2205	protein histidine kinase activity
HPY04_12610	COG0784	Response regulator, receiver
HPY04_12615	COG2814	Major facilitator Superfamily
HPY04_12630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY04_12635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY04_12640	COG0511	ligase activity, forming carbon-carbon bonds
HPY04_12645	COG0439	Biotin carboxylase
HPY04_12650	COG2264	protein methyltransferase activity
HPY04_12655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY04_12660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY04_12665	COG1609	Transcriptional regulator
HPY04_12670	COG0129	dihydroxy-acid dehydratase activity
HPY04_12675	COG3265	gluconokinase activity
HPY04_12685	COG0800	Aldolase
HPY04_12705	COG0840	transmembrane signaling receptor activity
HPY04_12710	COG1982	Orn Lys Arg decarboxylase major
HPY04_12715	COG0531	amino acid
HPY04_12720	COG3710	Transcriptional regulator
HPY04_12725	COG0789	Transcriptional regulator
HPY04_12740	COG0151	Belongs to the GarS family
HPY04_12750	COG0776	regulation of translation
HPY04_12755	COG1253	flavin adenine dinucleotide binding
HPY04_12770	COG3068	Protein conserved in bacteria
HPY04_12780	COG1573	uracil-dna glycosylase
HPY04_12785	COG0668	transmembrane transport
HPY04_12800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY04_12810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPY04_12845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY04_12860	COG1596	polysaccharide export
HPY04_12880	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_12890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY04_12925	COG0463	Glycosyl transferase, family 2
HPY04_12940	COG4106	trans-aconitate 2-methyltransferase activity
HPY04_12975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY04_12995	COG0859	PFAM glycosyl transferase family 9
HPY04_13005	COG1519	Transferase
HPY04_13010	COG0456	acetyltransferase
HPY04_13015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY04_13030	COG3642	lipopolysaccharide core region biosynthetic process
HPY04_13035	COG0859	PFAM glycosyl transferase family 9
HPY04_13040	COG0463	Glycosyl transferase, family 2
HPY04_13045	COG0859	PFAM glycosyl transferase family 9
HPY04_13050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY04_13055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY04_13065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY04_13070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY04_13075	COG2003	Belongs to the UPF0758 family
HPY04_13085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY04_13095	COG1309	transcriptional regulator
HPY04_13100	COG1560	Kdo2-lipid A biosynthetic process
HPY04_13105	COG1560	Kdo2-lipid A biosynthetic process
HPY04_13110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY04_13115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY04_13120	COG1561	YicC-like family, N-terminal region
HPY04_13135	COG0464	growth
HPY04_13140	COG1404	Belongs to the peptidase S8 family
HPY04_13265	COG2862	Uncharacterized protein family, UPF0114
HPY04_13270	COG1263	PTS System
HPY04_13270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_13275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY04_13295	COG1120	ATPase activity
HPY04_13300	COG4774	siderophore transport
HPY04_13305	COG1132	(ABC) transporter
HPY04_13320	COG0514	ATP-dependent DNA helicase (RecQ)
HPY04_13325	COG2962	Rard protein
HPY04_13330	COG0405	Gamma-glutamyltransferase
HPY04_13340	COG1280	lysine exporter protein (LysE YggA)
HPY04_13350	COG0210	DNA helicase
HPY04_13360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY04_13365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_13385	COG0747	negative chemotaxis
HPY04_13435	COG1309	transcriptional regulator
HPY04_13440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_13445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY04_13450	COG2960	long-chain fatty acid transporting porin activity
HPY04_13455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY04_13460	COG0583	DNA-binding transcription factor activity
HPY04_13530	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY04_13535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY04_13540	COG1739	Uncharacterized protein family UPF0029
HPY04_13545	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY04_13545	COG1024	Enoyl-CoA hydratase
HPY04_13550	COG0183	Belongs to the thiolase family
HPY04_13555	COG0583	DNA-binding transcription factor activity
HPY04_13560	COG2814	Major facilitator Superfamily
HPY04_13570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY04_13575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY04_13580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY04_13585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY04_13590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY04_13595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY04_13605	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY04_13610	COG3312	ion transport
HPY04_13615	COG1475	DNA binding
HPY04_13620	COG1192	Involved in chromosome partitioning
HPY04_13625	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY04_13630	COG0445	tRNA wobble uridine modification
HPY04_13635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY04_13640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY04_13645	COG0706	membrane insertase activity
HPY04_13655	COG0594	ribonuclease P activity
HPY04_13660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY04_13665	COG1126	abc transporter atp-binding protein
HPY04_13710	COG0217	transcriptional regulatory protein
HPY04_13715	COG2084	Dehydrogenase
HPY04_13730	COG2909	trisaccharide binding
HPY04_13735	COG0058	SHG alpha-glucan phosphorylase activity
HPY04_13740	COG1640	4-alpha-glucanotransferase
HPY04_13745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY04_13755	COG3501	Rhs element vgr protein
HPY04_13790	COG0471	metal ion transport
HPY04_13795	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY04_13835	COG0671	phosphoesterase, PA-phosphatase related
HPY04_13840	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY04_13850	COG1999	signal sequence binding
HPY04_13865	COG0786	glutamate:sodium symporter activity
HPY04_13885	COG3706	GGDEF domain
HPY04_13900	COG0813	purine-nucleoside phosphorylase activity
HPY04_13905	COG3272	Protein of unknown function (DUF1722)
HPY04_13915	COG0415	Belongs to the DNA photolyase family
HPY04_13920	COG1388	LysM domain
HPY04_13920	COG1376	ErfK ybiS ycfS ynhG family protein
HPY04_13930	COG0513	Belongs to the DEAD box helicase family
HPY04_13935	COG1770	oligopeptidase
HPY04_13965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY04_13970	COG0573	inorganic phosphate transmembrane transporter activity
HPY04_13975	COG0581	inorganic phosphate transmembrane transporter activity
HPY04_13980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY04_14005	COG0659	secondary active sulfate transmembrane transporter activity
HPY04_14015	COG0739	heme binding
HPY04_14020	COG5001	Diguanylate cyclase
HPY04_14020	COG3300	MHYT domain
HPY04_14025	COG0583	DNA-binding transcription factor activity
HPY04_14030	COG2814	Major facilitator Superfamily
HPY04_14050	COG1301	dicarboxylic acid transport
HPY04_14060	COG1342	Belongs to the UPF0251 family
HPY04_14090	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY04_14095	COG0673	inositol 2-dehydrogenase activity
HPY04_14105	COG2771	luxR family
HPY04_14105	COG2200	EAL domain
HPY04_14110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY04_14120	COG0564	pseudouridine synthase activity
HPY04_14210	COG3501	Rhs element vgr protein
HPY04_14225	COG1869	D-ribose catabolic process
HPY04_14230	COG1129	ABC transporter
HPY04_14235	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY04_14240	COG1879	ABC-type sugar transport system periplasmic component
HPY04_14245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_14250	COG1609	Transcriptional regulator
HPY04_14260	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY04_14270	COG0584	glycerophosphoryl diester phosphodiesterase
HPY04_14275	COG2271	Major facilitator Superfamily
HPY04_14310	COG0579	oxidoreductase
HPY04_14320	COG0242	peptide deformylase activity
HPY04_14330	COG1320	monovalent cation:proton antiporter activity
HPY04_14335	COG2212	antiporter activity
HPY04_14355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY04_14355	COG2111	Na H antiporter
HPY04_14365	COG0589	response to stress
HPY04_14370	COG0814	amino acid
HPY04_14385	COG3530	Putative quorum-sensing-regulated virulence factor
HPY04_14395	COG5001	Diguanylate cyclase
HPY04_14395	COG5002	protein histidine kinase activity
HPY04_14400	COG1278	Cold shock
HPY04_14415	COG2304	oxidoreductase activity
HPY04_14435	COG0714	Associated with various cellular activities
HPY04_14440	COG0840	transmembrane signaling receptor activity
HPY04_14455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY04_14460	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY04_14470	COG3604	Transcriptional regulator
HPY04_14475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY04_14475	COG1017	nitric oxide dioxygenase activity
HPY04_14480	COG1278	Cold shock
HPY04_14485	COG3036	rescue of stalled ribosome
HPY04_14510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY04_14510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY04_14515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY04_14525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY04_14535	COG0516	GMP reductase activity
HPY04_14545	COG4974	Belongs to the 'phage' integrase family
HPY04_14550	COG0464	growth
HPY04_14625	COG4695	Portal protein
HPY04_14765	COG2205	protein histidine kinase activity
HPY04_14770	COG0745	RESPONSE REGULATOR receiver
HPY04_14780	COG0569	domain protein
HPY04_14810	COG0513	Belongs to the DEAD box helicase family
HPY04_14815	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY04_14820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY04_14825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY04_14830	COG0784	Response regulator, receiver
HPY04_14830	COG3437	response regulator, receiver
HPY04_14835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_14835	COG4191	Histidine kinase
HPY04_14845	COG1757	Na H antiporter
HPY04_14850	COG2814	Major facilitator Superfamily
HPY04_14865	COG3240	lipase activity
HPY04_14875	COG0840	transmembrane signaling receptor activity
HPY04_14880	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY04_14885	COG5380	lipid catabolic process
HPY04_14910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_14915	COG4605	iron ion homeostasis
HPY04_14920	COG4604	ABC transporter, ATP-binding protein
HPY04_14925	COG2207	Transcriptional regulator
HPY04_14940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY04_14960	COG0745	RESPONSE REGULATOR receiver
HPY04_14970	COG3623	hexulose-6-phosphate isomerase
HPY04_14975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY04_14980	COG0561	phosphatase activity
HPY04_15030	COG0745	RESPONSE REGULATOR receiver
HPY04_15035	COG5002	protein histidine kinase activity
HPY04_15055	COG1686	Belongs to the peptidase S11 family
HPY04_15075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY04_15075	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY04_15080	COG0509	glycine decarboxylation via glycine cleavage system
HPY04_15085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY04_15095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY04_15110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY04_15115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY04_15125	COG3040	lipid binding
HPY04_15160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_15170	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_15185	COG3040	lipid binding
HPY04_15225	COG0456	acetyltransferase
HPY04_15525	COG3041	Addiction module toxin RelE StbE family
HPY04_15585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_15640	COG3549	Plasmid maintenance system killer
HPY04_15645	COG3093	addiction module antidote protein HigA
HPY04_15730	COG0110	maltose O-acetyltransferase activity
HPY04_15780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_15840	COG1418	mRNA catabolic process
HPY04_15850	COG5642	Protein of unknown function (DUF2384)
HPY04_15860	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY04_15870	COG1328	CTP reductase activity
HPY04_15875	COG0602	queuosine metabolic process
HPY04_15885	COG4067	protein conserved in archaea
HPY04_15885	COG0189	ligase activity
HPY04_15890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY04_15890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY04_15890	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY04_15895	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY04_15900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_15900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_15905	COG1609	Transcriptional regulator
HPY04_15910	COG0420	3'-5' exonuclease activity
HPY04_15915	COG0419	ATPase involved in DNA repair
HPY04_15920	COG0784	Response regulator, receiver
HPY04_15920	COG2205	protein histidine kinase activity
HPY04_15925	COG0156	8-amino-7-oxononanoate synthase activity
HPY04_15935	COG0038	chloride channel
HPY04_15940	COG0523	cobalamin synthesis protein
HPY04_15950	COG3158	transport of potassium into the cell
HPY04_15955	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY04_15955	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY04_15955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY04_15955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY04_15960	COG2205	protein histidine kinase activity
HPY04_15965	COG0745	RESPONSE REGULATOR receiver
HPY04_15970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY04_15975	COG0586	Pfam SNARE associated Golgi protein
HPY04_15985	COG2200	EAL domain
HPY04_15995	COG3038	cytochrome b561
HPY04_16005	COG2116	formate transmembrane transporter activity
HPY04_16010	COG0583	DNA-binding transcription factor activity
HPY04_16020	COG3593	DNA synthesis involved in DNA repair
HPY04_16025	COG0737	Belongs to the 5'-nucleotidase family
HPY04_16040	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY04_16090	COG3706	GGDEF domain
HPY04_16105	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY04_16110	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY04_16120	COG0745	RESPONSE REGULATOR receiver
HPY04_16135	COG3140	Belongs to the UPF0181 family
HPY04_16205	COG0023	Translation Initiation Factor
HPY04_16225	COG1042	CoA-binding domain protein
HPY04_16225	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY04_16225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_16230	COG0583	DNA-binding transcription factor activity
HPY04_16235	COG4771	TonB-dependent receptor
HPY04_16235	COG1629	transport
HPY04_16250	COG2050	protein possibly involved in aromatic compounds catabolism
HPY04_16270	COG0625	glutathione transferase activity
HPY04_16285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY04_16290	COG4172	Belongs to the ABC transporter superfamily
HPY04_16295	COG4239	(ABC) transporter, permease
HPY04_16305	COG4166	transmembrane transport
HPY04_16345	COG3842	ATPase activity
HPY04_16350	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY04_16355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY04_16365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY04_16370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY04_16380	COG3842	ATPase activity
HPY04_16390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_16405	COG1175	transmembrane transport
HPY04_16410	COG3833	ABC-type maltose transport systems, permease component
HPY04_16430	COG1011	Hydrolase
HPY04_16445	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY04_16450	COG1970	mechanosensitive ion channel activity
HPY04_16455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY04_16460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_16460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_16465	COG0302	gtp cyclohydrolase
HPY04_16475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY04_16485	COG2897	thiosulfate sulfurtransferase activity
HPY04_16490	COG2390	Transcriptional regulator
HPY04_16500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY04_16530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY04_16540	COG0494	nUDIX hydrolase
HPY04_16555	COG0583	DNA-binding transcription factor activity
HPY04_16560	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY04_16600	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY04_16650	COG0745	RESPONSE REGULATOR receiver
HPY04_16660	COG1263	PTS System
HPY04_16660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_16670	COG1621	beta-fructofuranosidase activity
HPY04_16675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_16680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY04_16690	COG2885	chlorophyll binding
HPY04_16695	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY04_16700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY04_16705	COG0840	transmembrane signaling receptor activity
HPY04_16710	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY04_16715	COG1760	l-serine dehydratase
HPY04_16720	COG2197	response regulator
HPY04_16725	COG3850	Histidine kinase
HPY04_16730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY04_16740	COG0243	molybdopterin cofactor binding
HPY04_16760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY04_16765	COG2197	response regulator
HPY04_16770	COG3851	Histidine kinase
HPY04_16775	COG2271	Major facilitator Superfamily
HPY04_16780	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY04_16790	COG3842	ATPase activity
HPY04_16795	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY04_16805	COG0183	Belongs to the thiolase family
HPY04_16815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_16820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_16835	COG3706	GGDEF domain
HPY04_16840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY04_16850	COG1979	alcohol dehydrogenase
HPY04_16865	COG4191	Histidine kinase
HPY04_16875	COG2271	Major facilitator Superfamily
HPY04_16880	COG0469	pyruvate kinase activity
HPY04_16890	COG1879	ABC-type sugar transport system periplasmic component
HPY04_16895	COG1803	Methylglyoxal synthase
HPY04_16900	COG1335	isochorismatase
HPY04_16905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY04_16910	COG0210	DNA helicase
HPY04_16915	COG1289	transmembrane transporter activity
HPY04_16945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY04_16950	COG4149	molybdate abc transporter
HPY04_16955	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY04_16960	COG1492	cobalamin metabolic process
HPY04_16995	COG5002	protein histidine kinase activity
HPY04_16995	COG0784	Response regulator, receiver
HPY04_17000	COG1879	ABC-type sugar transport system periplasmic component
HPY04_17010	COG2827	Endonuclease containing a URI domain
HPY04_17015	COG3132	Protein of unknown function, DUF480
HPY04_17025	COG2926	Belongs to the UPF0265 family
HPY04_17040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY04_17045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY04_17055	COG0247	lactate metabolic process
HPY04_17060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY04_17065	COG3118	belongs to the thioredoxin family
HPY04_17095	COG0583	DNA-binding transcription factor activity
HPY04_17100	COG4160	amino acid transport
HPY04_17105	COG4215	(ABC) transporter
HPY04_17110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_17115	COG1126	abc transporter atp-binding protein
HPY04_17125	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY04_17135	COG0494	nUDIX hydrolase
HPY04_17140	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY04_17150	COG1309	transcriptional regulator
HPY04_17155	COG0513	Belongs to the DEAD box helicase family
HPY04_17160	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY04_17165	COG0814	amino acid
HPY04_17170	COG0840	transmembrane signaling receptor activity
HPY04_17175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY04_17180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY04_17185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPY04_17190	COG1984	allophanate hydrolase subunit 2
HPY04_17205	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY04_17210	COG4181	ATPase activity
HPY04_17220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY04_17225	COG5001	Diguanylate cyclase
HPY04_17225	COG1716	ATPase activity
HPY04_17235	COG0484	heat shock protein binding
HPY04_17250	COG0546	phosphoglycolate phosphatase activity
HPY04_17265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_17270	COG1368	sulfuric ester hydrolase activity
HPY04_17280	COG0513	Belongs to the DEAD box helicase family
HPY04_17295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY04_17305	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY04_17310	COG3397	chitin binding
HPY04_17315	COG3227	Zinc metalloprotease (Elastase)
HPY04_17330	COG1166	arginine decarboxylase activity
HPY04_17340	COG2239	Acts as a magnesium transporter
HPY04_17345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY04_17350	COG0459	protein refolding
HPY04_17360	COG0527	aspartate kinase activity
HPY04_17365	COG0662	Cupin 2, conserved barrel domain protein
HPY04_17370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY04_17375	COG0456	acetyltransferase
HPY04_17380	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY04_17385	COG3186	Phenylalanine-4-hydroxylase
HPY04_17390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY04_17405	COG2264	protein methyltransferase activity
HPY04_17430	COG1253	flavin adenine dinucleotide binding
HPY04_17435	COG1765	OsmC-like protein
HPY04_17470	COG1252	NADH dehydrogenase
HPY04_17475	COG0531	amino acid
HPY04_17480	COG3706	GGDEF domain
HPY04_17490	COG3279	Response regulator of the LytR AlgR family
HPY04_17495	COG3275	phosphorelay sensor kinase activity
HPY04_17515	COG1136	(ABC) transporter
HPY04_17525	COG4989	oxidoreductase activity
HPY04_17530	COG0366	Alpha amylase catalytic
HPY04_17540	COG2067	long-chain fatty acid transport protein
HPY04_17545	COG2267	carboxylic ester hydrolase activity
HPY04_17555	COG3227	Zinc metalloprotease (Elastase)
HPY04_17565	COG3047	cAMP biosynthetic process
HPY04_17575	COG1686	Belongs to the peptidase S11 family
HPY04_17580	COG0557	exoribonuclease II activity
HPY04_17585	COG1278	Cold shock
HPY04_17595	COG3048	D-serine ammonia-lyase activity
HPY04_17600	COG0583	DNA-binding transcription factor activity
HPY04_17615	COG1162	GTPase activity
HPY04_17625	COG2264	protein methyltransferase activity
HPY04_17630	COG1063	alcohol dehydrogenase
HPY04_17655	COG1278	Cold shock
HPY04_17660	COG0557	exoribonuclease II activity
HPY04_17775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY04_17780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY04_17785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY04_17805	COG1278	Cold shock
HPY04_17830	COG4626	Terminase
HPY04_17830	COG1802	Transcriptional regulator
HPY04_17855	COG0582	viral genome integration into host DNA
HPY04_17880	COG1063	alcohol dehydrogenase
HPY04_17890	COG2873	o-acetylhomoserine
HPY04_17900	COG0346	lactoylglutathione lyase activity
HPY04_17925	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY04_17930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY04_17935	COG0363	glucosamine-6-phosphate deaminase activity
HPY04_17940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY04_17965	COG1929	Belongs to the glycerate kinase type-1 family
HPY04_17970	COG2610	gluconate transmembrane transporter activity
HPY04_17975	COG3835	regulator
HPY04_17985	COG0748	coenzyme F420 binding
HPY04_17990	COG3721	Heme iron utilization protein
HPY04_18000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY04_18005	COG0811	peptide transport
HPY04_18010	COG0848	biopolymer transport protein
HPY04_18015	COG4558	Periplasmic binding protein
HPY04_18020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_18025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY04_18060	COG0633	Ferredoxin
HPY04_18060	COG3217	Mosc domain protein beta barrel domain protein
HPY04_18060	COG0633	Ferredoxin
HPY04_18060	COG3217	Mosc domain protein beta barrel domain protein
HPY04_18065	COG0418	dihydroorotase activity
HPY04_18070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY04_18075	COG2354	Protein conserved in bacteria
HPY04_18080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY04_18085	COG1278	Cold shock
HPY04_18100	COG4753	response regulator
HPY04_18100	COG2207	Transcriptional regulator
HPY04_18110	COG3706	GGDEF domain
HPY04_18115	COG1349	DNA-binding transcription factor activity
HPY04_18130	COG3833	ABC-type maltose transport systems, permease component
HPY04_18135	COG1175	transmembrane transport
HPY04_18145	COG3842	ATPase activity
HPY04_18150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_18165	COG0393	Putative heavy-metal-binding
HPY04_18175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY04_18180	COG0784	Response regulator, receiver
HPY04_18180	COG0835	chemotaxis
HPY04_18185	COG1846	Transcriptional regulator
HPY04_18190	COG3706	GGDEF domain
HPY04_18225	COG0583	DNA-binding transcription factor activity
HPY04_18230	COG5001	Diguanylate cyclase
HPY04_18240	COG1741	Belongs to the pirin family
HPY04_18245	COG3123	guanosine phosphorylase activity
HPY04_18255	COG2211	Major facilitator Superfamily
HPY04_18260	COG1067	ATP-dependent peptidase activity
HPY04_18270	COG4172	Belongs to the ABC transporter superfamily
HPY04_18290	COG0583	DNA-binding transcription factor activity
HPY04_18300	COG1620	l-lactate permease
HPY04_18315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY04_18325	COG0840	transmembrane signaling receptor activity
HPY04_18335	COG1472	Belongs to the glycosyl hydrolase 3 family
HPY04_18345	COG4580	involved in the transport of maltose and maltodextrins
HPY04_18360	COG1609	Transcriptional regulator
HPY04_18370	COG4608	Belongs to the ABC transporter superfamily
HPY04_18375	COG0444	Belongs to the ABC transporter superfamily
HPY04_18380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_18390	COG0747	negative chemotaxis
HPY04_18400	COG0513	Belongs to the DEAD box helicase family
HPY04_18405	COG0583	DNA-binding transcription factor activity
HPY04_18415	COG1902	pentaerythritol trinitrate reductase activity
HPY04_18425	COG1132	(ABC) transporter
HPY04_18435	COG1902	pentaerythritol trinitrate reductase activity
HPY04_18445	COG1280	lysine exporter protein (LysE YggA)
HPY04_18450	COG2207	Transcriptional regulator
HPY04_18465	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPY04_18470	COG1846	Transcriptional regulator
HPY04_18475	COG1764	response to oxidative stress
HPY04_18480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY04_18485	COG0697	spore germination
HPY04_18495	COG0700	Nucleoside recognition
HPY04_18500	COG3366	ferrous iron transmembrane transporter activity
HPY04_18505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY04_18515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY04_18520	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY04_18525	COG2259	Doxx family
HPY04_18550	COG0363	glucosamine-6-phosphate deaminase activity
HPY04_18560	COG0583	DNA-binding transcription factor activity
HPY04_18565	COG0366	Alpha amylase catalytic
HPY04_18585	COG4580	involved in the transport of maltose and maltodextrins
HPY04_18600	COG0840	transmembrane signaling receptor activity
HPY04_18610	COG0840	transmembrane signaling receptor activity
HPY04_18620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY04_18625	COG1126	abc transporter atp-binding protein
HPY04_18635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_18640	COG4597	amino acid ABC transporter
HPY04_18645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY04_18650	COG2213	PTS system mannitol-specific
HPY04_18650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_18655	COG0246	Mannitol dehydrogenase
HPY04_18660	COG3722	fumarate hydratase activity
HPY04_18665	COG0673	inositol 2-dehydrogenase activity
HPY04_18685	COG0697	spore germination
HPY04_18700	COG1335	isochorismatase
HPY04_18710	COG2910	NAD(P)H-binding
HPY04_18720	COG0840	transmembrane signaling receptor activity
HPY04_18725	COG4221	oxidoreductase activity
HPY04_18730	COG0583	DNA-binding transcription factor activity
HPY04_18735	COG1901	pseudouridine methyltransferase
HPY04_18750	COG0531	amino acid
HPY04_18755	COG1982	Orn Lys Arg decarboxylase major
HPY04_18785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY04_18810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY04_18850	COG0745	RESPONSE REGULATOR receiver
HPY04_18875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY04_18880	COG0840	transmembrane signaling receptor activity
HPY04_18885	COG0835	chemotaxis
HPY04_18890	COG0835	chemotaxis
HPY04_18895	COG0643	Histidine kinase
HPY04_18895	COG2198	Histidine kinase
HPY04_18915	COG0601	transmembrane transport
HPY04_18920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_18930	COG2194	sulfuric ester hydrolase activity
HPY04_18935	COG0642	Histidine kinase
HPY04_18940	COG0745	RESPONSE REGULATOR receiver
HPY04_18970	COG1444	tRNA N-acetyltransferase activity
HPY04_18975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine