locus-tag	class	description
HPY17_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY17_00010	COG0592	DNA-directed DNA polymerase activity
HPY17_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY17_00020	COG0187	DNA topoisomerase II activity
HPY17_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY17_00035	COG3977	Valine--pyruvate aminotransferase
HPY17_00040	COG0751	glycine-tRNA ligase activity
HPY17_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY17_00050	COG2119	membrane
HPY17_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY17_00070	COG0604	alcohol dehydrogenase
HPY17_00080	COG0129	dihydroxy-acid dehydratase activity
HPY17_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY17_00100	COG0606	chelatase, subunit chli
HPY17_00105	COG0204	Acyl-transferase
HPY17_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY17_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY17_00125	COG3084	Protein conserved in bacteria
HPY17_00130	COG4326	sporulation control protein
HPY17_00135	COG1272	protein, Hemolysin III
HPY17_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY17_00150	COG0569	domain protein
HPY17_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY17_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY17_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY17_00165	COG0242	peptide deformylase activity
HPY17_00170	COG1652	LysM domain
HPY17_00175	COG0758	DNA mediated transformation
HPY17_00180	COG2922	Belongs to the Smg family
HPY17_00185	COG0551	DNA topoisomerase type I activity
HPY17_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY17_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY17_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY17_00205	COG0408	coproporphyrinogen oxidase activity
HPY17_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY17_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY17_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY17_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY17_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY17_00280	COG2104	thiamine diphosphate biosynthetic process
HPY17_00285	COG2022	thiamine diphosphate biosynthetic process
HPY17_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY17_00295	COG0006	proline dipeptidase activity
HPY17_00295	COG0006	proline dipeptidase activity
HPY17_00315	COG1522	sequence-specific DNA binding
HPY17_00320	COG5002	protein histidine kinase activity
HPY17_00320	COG5001	Diguanylate cyclase
HPY17_00340	COG0589	response to stress
HPY17_00345	COG1528	Iron-storage protein
HPY17_00355	COG2081	HI0933 family
HPY17_00365	COG1322	Protein conserved in bacteria
HPY17_00370	COG2226	methyltransferase
HPY17_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY17_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY17_00395	COG0805	protein transport
HPY17_00400	COG0534	Mate efflux family protein
HPY17_00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY17_00415	COG2937	Belongs to the GPAT DAPAT family
HPY17_00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY17_00425	COG3161	chorismate lyase activity
HPY17_00430	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY17_00445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY17_00450	COG0084	hydrolase, TatD family'
HPY17_00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY17_00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY17_00485	COG3078	GTPase activator activity
HPY17_00500	COG3071	HemY protein
HPY17_00505	COG2959	enzyme of heme biosynthesis
HPY17_00510	COG1587	Uroporphyrinogen-III synthase
HPY17_00515	COG0181	hydroxymethylbilane synthase activity
HPY17_00525	COG1965	Belongs to the frataxin family
HPY17_00535	COG0019	diaminopimelate decarboxylase activity
HPY17_00540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY17_00550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY17_00555	COG1011	Hydrolase
HPY17_00560	COG3287	FIST C domain
HPY17_00560	COG2200	EAL domain
HPY17_00560	COG2199	diguanylate cyclase activity
HPY17_00575	COG0561	phosphatase activity
HPY17_00580	COG2267	carboxylic ester hydrolase activity
HPY17_00585	COG1280	lysine exporter protein (LysE YggA)
HPY17_00590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY17_00595	COG0783	Belongs to the Dps family
HPY17_00625	COG0742	ribosomal rna small subunit methyltransferase
HPY17_00630	COG0552	protein localization to endoplasmic reticulum
HPY17_00635	COG2884	Cell division ATP-binding protein ftsE
HPY17_00640	COG2177	Part of the ABC transporter FtsEX involved in
HPY17_00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY17_00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY17_00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY17_00675	COG1404	Belongs to the peptidase S8 family
HPY17_00680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY17_00745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY17_00750	COG3300	MHYT domain
HPY17_00750	COG5001	Diguanylate cyclase
HPY17_00760	COG3852	Histidine kinase
HPY17_00770	COG0174	glutamine synthetase
HPY17_00790	COG1295	ribonuclease BN
HPY17_00795	COG1490	D-aminoacyl-tRNA deacylase activity
HPY17_00800	COG0456	acetyltransferase
HPY17_00810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY17_00815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY17_00820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY17_00825	COG3031	protein transport across the cell outer membrane
HPY17_00835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY17_00840	COG1459	type II secretion system
HPY17_00845	COG2165	general secretion pathway protein
HPY17_00850	COG2165	general secretion pathway protein
HPY17_00855	COG2165	general secretion pathway protein
HPY17_00860	COG4795	General secretion pathway protein
HPY17_00865	COG3156	type II secretion system protein K
HPY17_00870	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY17_00875	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY17_00885	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY17_00890	COG0494	nUDIX hydrolase
HPY17_00900	COG1040	competence protein
HPY17_00910	COG0596	Alpha beta hydrolase
HPY17_00920	COG2183	response to ionizing radiation
HPY17_00960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY17_00965	COG2199	diguanylate cyclase activity
HPY17_00970	COG0745	RESPONSE REGULATOR receiver
HPY17_00980	COG2233	PERMEase
HPY17_00985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY17_00990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY17_00995	COG1758	RNA polymerase activity
HPY17_01000	COG0194	GDP metabolic process
HPY17_01005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY17_01010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY17_01030	COG4232	protein-disulfide reductase activity
HPY17_01040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY17_01045	COG1027	Aspartate ammonia-lyase
HPY17_01050	COG3706	GGDEF domain
HPY17_01055	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY17_01060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY17_01070	COG2205	protein histidine kinase activity
HPY17_01075	COG0745	RESPONSE REGULATOR receiver
HPY17_01085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY17_01090	COG0205	6-phosphofructokinase activity
HPY17_01095	COG1494	fructose-1,6-bisphosphatase
HPY17_01100	COG3074	FtsZ-dependent cytokinesis
HPY17_01105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY17_01110	COG0460	homoserine dehydrogenase
HPY17_01110	COG0527	aspartate kinase activity
HPY17_01115	COG0626	cystathionine gamma-synthase activity
HPY17_01120	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY17_01125	COG0281	malic enzyme
HPY17_01130	COG0254	rRNA binding
HPY17_01135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY17_01140	COG1609	Transcriptional regulator
HPY17_01145	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY17_01150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY17_01155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY17_01160	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY17_01165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY17_01170	COG0534	Mate efflux family protein
HPY17_01175	COG0149	triose-phosphate isomerase activity
HPY17_01200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY17_01205	COG0459	protein refolding
HPY17_01215	COG1509	lysine 2,3-aminomutase activity
HPY17_01220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY17_01230	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY17_01235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY17_01240	COG1053	succinate dehydrogenase
HPY17_01245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY17_01250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY17_01255	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY17_01260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY17_01265	COG1045	serine acetyltransferase
HPY17_01275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY17_01280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY17_01285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY17_01290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY17_01295	COG0137	argininosuccinate synthase activity
HPY17_01300	COG0165	Argininosuccinate lyase
HPY17_01310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY17_01315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY17_01315	COG0678	peroxiredoxin activity
HPY17_01325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY17_01355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY17_01360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY17_01370	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY17_01375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY17_01380	COG0546	phosphoglycolate phosphatase activity
HPY17_01385	COG0180	Tryptophanyl-tRNA synthetase
HPY17_01405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY17_01415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY17_01425	COG1012	belongs to the aldehyde dehydrogenase family
HPY17_01440	COG3954	Phosphoribulokinase
HPY17_01450	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY17_01460	COG0488	(ABC) transporter
HPY17_01465	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY17_01480	COG1047	Peptidyl-prolyl cis-trans
HPY17_01490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY17_01495	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY17_01500	COG3083	sulfuric ester hydrolase activity
HPY17_01505	COG0557	exoribonuclease II activity
HPY17_01510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY17_01515	COG0051	transcription antitermination factor activity, RNA binding
HPY17_01520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY17_01525	COG0088	Forms part of the polypeptide exit tunnel
HPY17_01530	COG0089	rRNA binding
HPY17_01535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY17_01540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY17_01545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY17_01550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY17_01555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY17_01560	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY17_01565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY17_01570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY17_01575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY17_01580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY17_01585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY17_01590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY17_01595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY17_01600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY17_01605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY17_01610	COG1841	ribosomal large subunit assembly
HPY17_01620	COG0201	protein transport
HPY17_01625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY17_01630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY17_01635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY17_01640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY17_01645	COG0202	RNA polymerase activity
HPY17_01650	COG0203	ribosomal protein L17
HPY17_01660	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY17_01665	COG3061	Opacity-associated protein A
HPY17_01665	COG3266	domain, Protein
HPY17_01670	COG0697	spore germination
HPY17_01675	COG2153	protein acetylation
HPY17_01680	COG0513	Belongs to the DEAD box helicase family
HPY17_01690	COG0737	Belongs to the 5'-nucleotidase family
HPY17_01695	COG1648	precorrin-2 dehydrogenase activity
HPY17_01695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY17_01700	COG0175	sulfate reduction
HPY17_01705	COG2895	sulfate adenylyltransferase (ATP) activity
HPY17_01710	COG0529	Catalyzes the synthesis of activated sulfate
HPY17_01730	COG1136	(ABC) transporter
HPY17_01745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY17_01750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY17_01755	COG0729	surface antigen
HPY17_01765	COG2105	PFAM AIG2 family protein
HPY17_01770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY17_01780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY17_01785	COG0163	prenyltransferase activity
HPY17_01795	COG1178	ABC-type Fe3 transport system permease component
HPY17_01800	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY17_01805	COG3028	Belongs to the UPF0307 family
HPY17_01810	COG0312	modulator of DNA gyrase
HPY17_01815	COG2239	Acts as a magnesium transporter
HPY17_01820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY17_01825	COG1660	Displays ATPase and GTPase activities
HPY17_01830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY17_01835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY17_01845	COG1137	ATPase activity
HPY17_01850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY17_01865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY17_01865	COG0517	IMP dehydrogenase activity
HPY17_01875	COG1127	ABC transporter
HPY17_01880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY17_01885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY17_01890	COG2854	intermembrane phospholipid transfer
HPY17_01900	COG5007	Belongs to the BolA IbaG family
HPY17_01905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY17_01915	COG0251	oxidation-reduction process
HPY17_01925	COG0540	Belongs to the ATCase OTCase family
HPY17_01935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY17_01940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY17_01945	COG0564	pseudouridine synthase activity
HPY17_01950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY17_01955	COG0525	valine-tRNA ligase activity
HPY17_01960	COG2927	DNA polymerase III (CHI subunit)
HPY17_01965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY17_01970	COG0795	lipopolysaccharide-transporting ATPase activity
HPY17_01975	COG0795	lipopolysaccharide-transporting ATPase activity
HPY17_01990	COG3437	response regulator, receiver
HPY17_02030	COG0066	3-isopropylmalate dehydratase activity
HPY17_02035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY17_02040	COG0473	3-isopropylmalate dehydrogenase activity
HPY17_02060	COG0583	DNA-binding transcription factor activity
HPY17_02065	COG1022	Amp-dependent synthetase and ligase
HPY17_02070	COG0028	Belongs to the TPP enzyme family
HPY17_02075	COG0440	acetolactate synthase activity
HPY17_02080	COG3385	transposase activity
HPY17_02085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY17_02090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY17_02095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY17_02105	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY17_02110	COG3079	Belongs to the UPF0149 family
HPY17_02115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY17_02120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY17_02135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY17_02145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY17_02150	COG1595	DNA-templated transcription, initiation
HPY17_02165	COG3086	response to oxidative stress
HPY17_02170	COG0481	GTPase activity
HPY17_02180	COG0571	ribonuclease III activity
HPY17_02185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY17_02190	COG1381	Involved in DNA repair and RecF pathway recombination
HPY17_02195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY17_02230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY17_02235	COG3956	TIGRFAM MazG family protein
HPY17_02240	COG0504	CTP synthase activity
HPY17_02245	COG0148	phosphopyruvate hydratase activity
HPY17_02255	COG3267	Type II secretory pathway component ExeA
HPY17_02255	COG3409	Peptidoglycan-binding domain 1 protein
HPY17_02265	COG4991	sh3 domain protein
HPY17_02270	COG0306	phosphate transporter
HPY17_02275	COG1392	Phosphate transport regulator
HPY17_02280	COG3025	triphosphatase activity
HPY17_02285	COG0840	transmembrane signaling receptor activity
HPY17_02290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY17_02295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY17_02295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY17_02300	COG1538	Outer membrane efflux protein
HPY17_02305	COG0494	nUDIX hydrolase
HPY17_02310	COG3151	Protein conserved in bacteria
HPY17_02320	COG3150	esterase
HPY17_02325	COG0187	DNA topoisomerase II activity
HPY17_02330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY17_02340	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY17_02345	COG0237	dephospho-CoA kinase activity
HPY17_02355	COG1459	type II secretion system
HPY17_02360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY17_02380	COG0716	FMN binding
HPY17_02385	COG4974	Belongs to the 'phage' integrase family
HPY17_02390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY17_02395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY17_02400	COG2186	Transcriptional regulator
HPY17_02405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY17_02410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY17_02415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY17_02430	COG3116	cell division
HPY17_02435	COG0768	penicillin binding
HPY17_02440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY17_02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY17_02455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY17_02460	COG0772	Belongs to the SEDS family
HPY17_02465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY17_02470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY17_02475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY17_02480	COG0849	cell division
HPY17_02485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY17_02490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY17_02500	COG0653	protein targeting
HPY17_02505	COG0494	nUDIX hydrolase
HPY17_02510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY17_02520	COG0505	Belongs to the CarA family
HPY17_02525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY17_02540	COG0730	response to heat
HPY17_02545	COG0583	DNA-binding transcription factor activity
HPY17_02550	COG2860	membrane
HPY17_02555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY17_02565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY17_02575	COG0493	'glutamate synthase
HPY17_02580	COG0069	glutamate synthase activity
HPY17_02580	COG0067	glutamate synthase
HPY17_02580	COG0070	glutamate synthase
HPY17_02590	COG0070	glutamate synthase
HPY17_02590	COG0069	glutamate synthase activity
HPY17_02590	COG0067	glutamate synthase
HPY17_02595	COG1242	4 iron, 4 sulfur cluster binding
HPY17_02600	COG4251	negative regulation of phosphorylation
HPY17_02600	COG5001	Diguanylate cyclase
HPY17_02600	COG3706	GGDEF domain
HPY17_02600	COG2203	Gaf domain
HPY17_02605	COG5002	protein histidine kinase activity
HPY17_02605	COG2198	Histidine kinase
HPY17_02605	COG0784	Response regulator, receiver
HPY17_02610	COG0745	RESPONSE REGULATOR receiver
HPY17_02620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY17_02640	COG0083	homoserine kinase activity
HPY17_02645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY17_02650	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY17_02655	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY17_02660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY17_02675	COG1115	amino acid carrier protein
HPY17_02680	COG3022	response to hydroperoxide
HPY17_02690	COG0084	hydrolase, TatD family'
HPY17_02695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY17_02705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY17_02710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY17_02715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY17_02720	COG0813	purine-nucleoside phosphorylase activity
HPY17_02730	COG0560	Phosphoserine phosphatase
HPY17_02740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY17_02745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY17_02750	COG1022	Amp-dependent synthetase and ligase
HPY17_02765	COG3250	beta-galactosidase activity
HPY17_02775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY17_02790	COG0189	ligase activity
HPY17_02790	COG0569	domain protein
HPY17_02795	COG0456	acetyltransferase
HPY17_02805	COG2171	N-acyltransferase activity
HPY17_02810	COG3141	response to X-ray
HPY17_02825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY17_02830	COG1074	ATP-dependent DNA helicase activity
HPY17_02835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY17_02845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY17_02845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY17_02855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY17_02860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY17_02865	COG2166	iron-sulfur cluster assembly
HPY17_02870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY17_02875	COG0693	protein deglycase activity
HPY17_02880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY17_02885	COG3248	Nucleoside-binding outer membrane protein
HPY17_02895	COG1595	DNA-templated transcription, initiation
HPY17_02905	COG2211	Major facilitator Superfamily
HPY17_02920	COG2813	Specifically methylates the guanine in position
HPY17_02925	COG0271	Belongs to the BolA IbaG family
HPY17_02930	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY17_02935	COG1805	sodium ion transport
HPY17_02940	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY17_02945	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY17_02950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY17_02955	COG2871	sodium ion transport
HPY17_02960	COG1477	protein flavinylation
HPY17_02980	COG3706	GGDEF domain
HPY17_02985	COG0733	neurotransmitter:sodium symporter activity
HPY17_02995	COG0189	ligase activity
HPY17_03000	COG4067	protein conserved in archaea
HPY17_03000	COG0189	ligase activity
HPY17_03005	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY17_03010	COG2252	PERMEase
HPY17_03015	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY17_03030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY17_03035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY17_03040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY17_03045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY17_03045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY17_03060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY17_03065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY17_03070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY17_03075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY17_03085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY17_03090	COG0024	Methionine aminopeptidase
HPY17_03095	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY17_03100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY17_03105	COG0528	UMP kinase activity
HPY17_03110	COG0233	cytoplasmic translational termination
HPY17_03115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY17_03120	COG0575	Belongs to the CDS family
HPY17_03125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY17_03130	COG0750	zinc metalloprotease
HPY17_03140	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY17_03145	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY17_03150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY17_03155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY17_03160	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY17_03165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY17_03170	COG0587	DNA-directed DNA polymerase activity
HPY17_03175	COG0825	malonyl-CoA metabolic process
HPY17_03180	COG0037	tRNA processing
HPY17_03190	COG3479	Phenolic acid decarboxylase
HPY17_03195	COG0347	Belongs to the P(II) protein family
HPY17_03200	COG3021	interspecies interaction between organisms
HPY17_03205	COG0741	lytic transglycosylase activity
HPY17_03205	COG1388	LysM domain
HPY17_03210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY17_03215	COG2226	methyltransferase
HPY17_03220	COG0328	RNA-DNA hybrid ribonuclease activity
HPY17_03235	COG1960	acyl-CoA dehydrogenase activity
HPY17_03240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY17_03245	COG0121	glutamine amidotransferase
HPY17_03250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY17_03255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY17_03260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY17_03265	COG3706	GGDEF domain
HPY17_03270	COG1187	pseudouridine synthase activity
HPY17_03275	COG2840	Smr protein MutS2
HPY17_03290	COG3735	TraB family
HPY17_03305	COG2608	mercury ion transmembrane transporter activity
HPY17_03305	COG2217	Heavy metal translocating P-type atpase
HPY17_03310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY17_03325	COG4774	siderophore transport
HPY17_03325	COG1629	transport
HPY17_03330	COG2375	cellular response to nickel ion
HPY17_03335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY17_03335	COG3433	isochorismatase activity
HPY17_03335	COG2226	methyltransferase
HPY17_03370	COG0784	Response regulator, receiver
HPY17_03370	COG0835	chemotaxis
HPY17_03375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY17_03380	COG1815	bacterial-type flagellum-dependent cell motility
HPY17_03395	COG1749	Flagellar hook protein flgE
HPY17_03400	COG4787	bacterial-type flagellum-dependent cell motility
HPY17_03410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY17_03415	COG1706	bacterial-type flagellum-dependent cell motility
HPY17_03420	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY17_03420	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY17_03435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY17_03440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY17_03525	COG0012	GTP binding
HPY17_03530	COG0193	aminoacyl-tRNA hydrolase activity
HPY17_03535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY17_03540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY17_03545	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY17_03550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY17_03555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY17_03560	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY17_03570	COG2912	Transglutaminase-like superfamily
HPY17_03575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY17_03580	COG0737	Belongs to the 5'-nucleotidase family
HPY17_03585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY17_03590	COG2233	PERMEase
HPY17_03610	COG1393	Belongs to the ArsC family
HPY17_03615	COG4783	chaperone-mediated protein folding
HPY17_03635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY17_03650	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY17_03660	COG1876	peptidase activity
HPY17_03670	COG1393	Belongs to the ArsC family
HPY17_03690	COG2837	iron assimilation
HPY17_03695	COG2706	6-phosphogluconolactonase activity
HPY17_03705	COG0800	Aldolase
HPY17_03715	COG4145	pantothenate transmembrane transporter activity
HPY17_03725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPY17_03735	COG0837	glucose binding
HPY17_03735	COG1737	Transcriptional regulator
HPY17_03740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY17_03745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY17_03750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY17_03755	COG1334	flagellar protein FlaG
HPY17_03760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY17_03770	COG1516	flagellar protein fliS
HPY17_03780	COG4191	Histidine kinase
HPY17_03790	COG1677	Flagellar hook-basal body complex protein FliE
HPY17_03800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY17_03830	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY17_03855	COG1987	bacterial-type flagellum assembly
HPY17_03860	COG1684	flagellar biosynthetic protein fliR
HPY17_03870	COG2840	Smr protein MutS2
HPY17_03875	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY17_03880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY17_03885	COG2860	membrane
HPY17_03890	COG3101	peptidyl-lysine hydroxylation
HPY17_03900	COG0431	NADPH-dependent FMN reductase
HPY17_03905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY17_03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY17_03910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY17_03915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY17_03920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY17_03925	COG0735	belongs to the Fur family
HPY17_03935	COG0583	DNA-binding transcription factor activity
HPY17_03945	COG1346	cytolysis
HPY17_03960	COG0596	Alpha beta hydrolase
HPY17_03965	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY17_03970	COG0033	Phosphoglucomutase
HPY17_03980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY17_03985	COG0372	Belongs to the citrate synthase family
HPY17_03990	COG2009	succinate dehydrogenase
HPY17_03995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY17_04000	COG1053	succinate dehydrogenase
HPY17_04010	COG0567	Dehydrogenase, E1 component
HPY17_04015	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY17_04020	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY17_04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY17_04035	COG1121	(ABC) transporter
HPY17_04040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY17_04045	COG4977	sequence-specific DNA binding
HPY17_04050	COG1918	ferrous iron import across plasma membrane
HPY17_04070	COG0018	arginyl-trna synthetase
HPY17_04080	COG1025	Belongs to the peptidase M16 family
HPY17_04085	COG2062	phosphohistidine phosphatase, SixA
HPY17_04115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY17_04120	COG0643	Histidine kinase
HPY17_04120	COG2198	Histidine kinase
HPY17_04120	COG0784	Response regulator, receiver
HPY17_04125	COG2201	protein-glutamate methylesterase activity
HPY17_04130	COG1192	Involved in chromosome partitioning
HPY17_04140	COG0835	chemotaxis
HPY17_04150	COG4133	protoheme IX ABC transporter activity
HPY17_04155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY17_04160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY17_04170	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY17_04175	COG1138	Cytochrome C-type biogenesis protein
HPY17_04180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY17_04185	COG4235	cytochrome complex assembly
HPY17_04185	COG3088	subunit of a heme lyase
HPY17_04195	COG2853	Lipoprotein
HPY17_04215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY17_04220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY17_04225	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY17_04240	COG3083	sulfuric ester hydrolase activity
HPY17_04245	COG3082	Protein of unknown function (DUF1414)
HPY17_04250	COG3081	Nucleoid-associated protein
HPY17_04260	COG1757	Na H antiporter
HPY17_04265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY17_04270	COG2095	MarC family integral membrane protein
HPY17_04275	COG1454	alcohol dehydrogenase
HPY17_04275	COG1012	belongs to the aldehyde dehydrogenase family
HPY17_04285	COG0659	secondary active sulfate transmembrane transporter activity
HPY17_04290	COG1530	ribonuclease E activity
HPY17_04295	COG0564	pseudouridine synthase activity
HPY17_04300	COG0424	maF-like protein
HPY17_04305	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY17_04310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY17_04315	COG0416	fatty acid biosynthetic process
HPY17_04320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY17_04330	COG1028	Short-chain dehydrogenase reductase Sdr
HPY17_04335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY17_04340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY17_04345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY17_04350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY17_04355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY17_04365	COG0084	hydrolase, TatD family'
HPY17_04370	COG1263	PTS System
HPY17_04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY17_04380	COG0733	neurotransmitter:sodium symporter activity
HPY17_04395	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY17_04405	COG1940	carbohydrate kinase activity
HPY17_04410	COG0835	chemotaxis
HPY17_04410	COG0784	Response regulator, receiver
HPY17_04425	COG2226	methyltransferase
HPY17_04435	COG0676	glucose-6-phosphate 1-epimerase activity
HPY17_04440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY17_04445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY17_04455	COG3139	Protein of unknown function (DUF1315)
HPY17_04460	COG0252	asparaginase activity
HPY17_04465	COG0616	signal peptide processing
HPY17_04470	COG1902	pentaerythritol trinitrate reductase activity
HPY17_04470	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY17_04475	COG0788	formyltetrahydrofolate deformylase activity
HPY17_04485	COG1199	ATP-dependent helicase activity
HPY17_04490	COG1214	PFAM Peptidase M22, glycoprotease
HPY17_04505	COG0596	Alpha beta hydrolase
HPY17_04510	COG0318	PFAM AMP-dependent synthetase and ligase
HPY17_04515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY17_04530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY17_04535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY17_04540	COG0436	Aminotransferase
HPY17_04545	COG1169	isochorismate synthase
HPY17_04550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY17_04555	COG0596	Alpha beta hydrolase
HPY17_04575	COG3135	benzoate transporter
HPY17_04600	COG3015	lipoprotein NlpE involved in copper resistance
HPY17_04605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY17_04610	COG2894	cell division
HPY17_04615	COG0850	regulation of cytokinetic process
HPY17_04620	COG3100	YcgL domain-containing protein
HPY17_04625	COG2951	lytic endotransglycosylase activity
HPY17_04635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY17_04640	COG3005	denitrification pathway
HPY17_04645	COG0243	molybdopterin cofactor binding
HPY17_04660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY17_04675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY17_04710	COG0653	protein targeting
HPY17_04820	COG4589	Belongs to the CDS family
HPY17_04830	COG5001	Diguanylate cyclase
HPY17_04830	COG3300	MHYT domain
HPY17_04840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY17_04845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY17_04850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY17_04855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY17_04865	COG4191	Histidine kinase
HPY17_04875	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY17_04885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY17_04890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY17_04895	COG0776	regulation of translation
HPY17_04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY17_04905	COG1555	photosystem II stabilization
HPY17_04910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY17_04915	COG0539	negative regulation of cytoplasmic translation
HPY17_04920	COG0776	regulation of translation
HPY17_04925	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY17_04930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY17_04950	COG0583	DNA-binding transcription factor activity
HPY17_04960	COG0686	Belongs to the AlaDH PNT family
HPY17_04970	COG1674	ftsk spoiiie
HPY17_04975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY17_04980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY17_04985	COG2186	Transcriptional regulator
HPY17_05000	COG0537	adenosine 5'-monophosphoramidase activity
HPY17_05025	COG3150	esterase
HPY17_05030	COG1252	NADH dehydrogenase
HPY17_05055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY17_05065	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY17_05070	COG1136	(ABC) transporter
HPY17_05075	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY17_05085	COG2333	competence protein COMEC
HPY17_05085	COG0658	competence protein
HPY17_05090	COG1132	(ABC) transporter
HPY17_05095	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY17_05100	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY17_05105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY17_05110	COG2719	SpoVR family
HPY17_05115	COG2718	Belongs to the UPF0229 family
HPY17_05120	COG2766	serine protein kinase
HPY17_05125	COG3013	Belongs to the UPF0304 family
HPY17_05135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY17_05140	COG0840	transmembrane signaling receptor activity
HPY17_05150	COG1882	Formate acetyltransferase
HPY17_05175	COG4160	amino acid transport
HPY17_05180	COG0708	Exodeoxyribonuclease III
HPY17_05190	COG3923	Primosomal replication protein n
HPY17_05195	COG0730	response to heat
HPY17_05200	COG1199	ATP-dependent helicase activity
HPY17_05210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY17_05215	COG3012	SEC-C Motif Domain Protein
HPY17_05220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY17_05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY17_05230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY17_05235	COG0215	cysteine-tRNA ligase activity
HPY17_05240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY17_05245	COG0632	four-way junction helicase activity
HPY17_05255	COG1271	oxidase subunit
HPY17_05260	COG1294	oxidase, subunit
HPY17_05265	COG4890	Cyd operon protein YbgT
HPY17_05270	COG3790	cyd operon protein YbgE
HPY17_05275	COG0824	Thioesterase
HPY17_05280	COG0811	peptide transport
HPY17_05295	COG0823	Involved in the tonB-independent uptake of proteins
HPY17_05300	COG2885	chlorophyll binding
HPY17_05310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY17_05320	COG5002	protein histidine kinase activity
HPY17_05320	COG0784	Response regulator, receiver
HPY17_05330	COG1482	cell wall glycoprotein biosynthetic process
HPY17_05335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY17_05335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY17_05335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY17_05340	COG2207	Transcriptional regulator
HPY17_05350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY17_05355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY17_05360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY17_05370	COG1012	belongs to the aldehyde dehydrogenase family
HPY17_05375	COG3284	Transcriptional regulator
HPY17_05380	COG4628	conserved protein (DUF2132)
HPY17_05390	COG0415	Belongs to the DNA photolyase family
HPY17_05425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY17_05435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY17_05435	COG3008	intermembrane lipid transfer
HPY17_05440	COG2995	paraquat-inducible protein a
HPY17_05445	COG0668	transmembrane transport
HPY17_05465	COG1309	transcriptional regulator
HPY17_05470	COG1012	belongs to the aldehyde dehydrogenase family
HPY17_05490	COG1960	acyl-CoA dehydrogenase activity
HPY17_05495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY17_05500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY17_05510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY17_05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY17_05530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY17_05535	COG0297	glycogen (starch) synthase activity
HPY17_05555	COG3070	regulator of competence-specific genes
HPY17_05560	COG1609	Transcriptional regulator
HPY17_05570	COG0745	RESPONSE REGULATOR receiver
HPY17_05575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY17_05580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY17_05585	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY17_05590	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY17_05605	COG1280	lysine exporter protein (LysE YggA)
HPY17_05610	COG1032	radical SAM domain protein
HPY17_05615	COG5001	Diguanylate cyclase
HPY17_05620	COG0612	Peptidase, M16
HPY17_05635	COG0583	DNA-binding transcription factor activity
HPY17_05640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY17_05650	COG2350	Protein conserved in bacteria
HPY17_05655	COG1607	acyl-coa hydrolase
HPY17_05670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY17_05675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY17_05685	COG2116	formate transmembrane transporter activity
HPY17_05690	COG4459	periplasmic nitrate reductase
HPY17_05695	COG3005	denitrification pathway
HPY17_05700	COG0243	molybdopterin cofactor binding
HPY17_05720	COG1227	inorganic diphosphatase activity
HPY17_05740	COG4172	Belongs to the ABC transporter superfamily
HPY17_05755	COG4168	peptide transport system, permease
HPY17_05765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY17_05770	COG1842	Phage shock protein A
HPY17_05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY17_05800	COG2818	Glycosylase
HPY17_05805	COG0626	cystathionine gamma-synthase activity
HPY17_05815	COG0733	neurotransmitter:sodium symporter activity
HPY17_05840	COG0564	pseudouridine synthase activity
HPY17_05845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY17_05850	COG4136	ATPase activity
HPY17_05855	COG4135	transport system, permease component
HPY17_05860	COG4134	Bacterial extracellular solute-binding protein
HPY17_05870	COG3313	Fe-S protein
HPY17_05880	COG0814	amino acid
HPY17_05890	COG2239	Acts as a magnesium transporter
HPY17_05895	COG2205	protein histidine kinase activity
HPY17_05895	COG0784	Response regulator, receiver
HPY17_05910	COG4934	collagen metabolic process
HPY17_05945	COG0840	transmembrane signaling receptor activity
HPY17_05955	COG5001	Diguanylate cyclase
HPY17_05955	COG2203	Gaf domain
HPY17_05955	COG3706	GGDEF domain
HPY17_05955	COG4251	negative regulation of phosphorylation
HPY17_05960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY17_05980	COG1061	Type III restriction enzyme res subunit
HPY17_05985	COG1187	pseudouridine synthase activity
HPY17_05990	COG2814	Major facilitator Superfamily
HPY17_06000	COG0702	epimerase
HPY17_06005	COG0534	Mate efflux family protein
HPY17_06010	COG4181	ATPase activity
HPY17_06025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY17_06035	COG1748	Saccharopine dehydrogenase
HPY17_06050	COG1538	Outer membrane efflux protein
HPY17_06105	COG0583	DNA-binding transcription factor activity
HPY17_06115	COG1451	nucleotide metabolic process
HPY17_06130	COG3063	Type IV pilus biogenesis stability protein PilW
HPY17_06135	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY17_06155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY17_06170	COG3290	protein histidine kinase activity
HPY17_06175	COG4565	transcriptional regulatory protein
HPY17_06185	COG0784	Response regulator, receiver
HPY17_06185	COG0835	chemotaxis
HPY17_06235	COG1085	galactose-1-phosphate uridylyltransferase
HPY17_06240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY17_06245	COG2017	converts alpha-aldose to the beta-anomer
HPY17_06260	COG3527	Alpha-acetolactate decarboxylase
HPY17_06270	COG3064	Membrane
HPY17_06280	COG0753	catalase activity
HPY17_06300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY17_06350	COG1271	oxidase subunit
HPY17_06355	COG1294	oxidase, subunit
HPY17_06360	COG1136	(ABC) transporter
HPY17_06360	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY17_06365	COG1136	(ABC) transporter
HPY17_06365	COG0577	efflux transmembrane transporter activity
HPY17_06370	COG1136	(ABC) transporter
HPY17_06370	COG0577	efflux transmembrane transporter activity
HPY17_06400	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HPY17_06445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY17_06460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY17_06470	COG2723	6-phospho-beta-galactosidase activity
HPY17_06475	COG1609	Transcriptional regulator
HPY17_06480	COG0251	oxidation-reduction process
HPY17_06485	COG2731	YhcH YjgK YiaL family protein
HPY17_06490	COG0584	glycerophosphoryl diester phosphodiesterase
HPY17_06495	COG1349	DNA-binding transcription factor activity
HPY17_06500	COG3842	ATPase activity
HPY17_06505	COG0395	ABC-type sugar transport system, permease component
HPY17_06510	COG1175	transmembrane transport
HPY17_06525	COG0811	peptide transport
HPY17_06530	COG0811	peptide transport
HPY17_06535	COG0848	biopolymer transport protein
HPY17_06540	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY17_06550	COG1793	dna ligase
HPY17_06560	COG0534	Mate efflux family protein
HPY17_06570	COG3001	Fructosamine kinase
HPY17_06580	COG0791	NLP P60 protein
HPY17_06585	COG0840	transmembrane signaling receptor activity
HPY17_06600	COG1940	carbohydrate kinase activity
HPY17_06610	COG0303	'Molybdopterin
HPY17_06615	COG0746	molybdenum cofactor guanylyltransferase activity
HPY17_06620	COG3842	ATPase activity
HPY17_06625	COG4662	Binding-protein-dependent transport system inner membrane component
HPY17_06635	COG2204	response regulator
HPY17_06640	COG3852	Histidine kinase
HPY17_06645	COG0488	(ABC) transporter
HPY17_06650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY17_06680	COG0243	molybdopterin cofactor binding
HPY17_06680	COG3383	formate dehydrogenase (NAD+) activity
HPY17_06685	COG0437	4 iron, 4 sulfur cluster binding
HPY17_06700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY17_06705	COG1666	GTP binding
HPY17_06710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY17_06725	COG2996	Protein conserved in bacteria
HPY17_06735	COG3008	intermembrane lipid transfer
HPY17_06740	COG2995	paraquat-inducible protein a
HPY17_06745	COG1132	(ABC) transporter
HPY17_06750	COG1956	GAF domain-containing protein
HPY17_06755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY17_06770	COG0308	aminopeptidase N
HPY17_06785	COG0167	dihydroorotate dehydrogenase activity
HPY17_06795	COG0116	Belongs to the methyltransferase superfamily
HPY17_06795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY17_06820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY17_06825	COG1067	ATP-dependent peptidase activity
HPY17_06830	COG3120	sequence-specific DNA binding
HPY17_06970	COG1073	alpha beta
HPY17_06970	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY17_06970	COG3064	Membrane
HPY17_06975	COG2994	toxin metabolic process
HPY17_07000	COG2205	protein histidine kinase activity
HPY17_07000	COG0784	Response regulator, receiver
HPY17_07015	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY17_07030	COG2010	Cytochrome c
HPY17_07040	COG2217	Heavy metal translocating P-type atpase
HPY17_07055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY17_07060	COG0589	response to stress
HPY17_07065	COG0037	tRNA processing
HPY17_07085	COG3842	ATPase activity
HPY17_07095	COG1177	transmembrane transport
HPY17_07105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY17_07120	COG1115	amino acid carrier protein
HPY17_07125	COG1280	lysine exporter protein (LysE YggA)
HPY17_07155	COG3501	Rhs element vgr protein
HPY17_07165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY17_07170	COG1960	acyl-CoA dehydrogenase activity
HPY17_07180	COG1012	belongs to the aldehyde dehydrogenase family
HPY17_07185	COG3384	dioxygenase
HPY17_07220	COG3971	2-oxopent-4-enoate hydratase activity
HPY17_07240	COG1846	Transcriptional regulator
HPY17_07300	COG0513	Belongs to the DEAD box helicase family
HPY17_07305	COG2076	Multidrug Resistance protein
HPY17_07310	COG0477	Major facilitator Superfamily
HPY17_07315	COG0583	DNA-binding transcription factor activity
HPY17_07325	COG0402	S-adenosylhomocysteine deaminase activity
HPY17_07330	COG0095	Lipoate-protein ligase
HPY17_07335	COG0443	Heat shock 70 kDa protein
HPY17_07345	COG1643	Atp-dependent helicase
HPY17_07375	COG0443	Heat shock 70 kDa protein
HPY17_07380	COG0443	Heat shock 70 kDa protein
HPY17_07385	COG3706	GGDEF domain
HPY17_07415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY17_07420	COG0602	queuosine metabolic process
HPY17_07425	COG0561	phosphatase activity
HPY17_07435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY17_07440	COG4597	amino acid ABC transporter
HPY17_07445	COG0765	amino acid transport
HPY17_07450	COG1126	abc transporter atp-binding protein
HPY17_07455	COG0670	Belongs to the BI1 family
HPY17_07460	COG2920	part of a sulfur-relay system
HPY17_07465	COG1254	Belongs to the acylphosphatase family
HPY17_07475	COG3706	GGDEF domain
HPY17_07485	COG2205	protein histidine kinase activity
HPY17_07485	COG3437	response regulator, receiver
HPY17_07485	COG3850	Histidine kinase
HPY17_07485	COG4999	Histidine kinase
HPY17_07490	COG3437	response regulator, receiver
HPY17_07495	COG0625	glutathione transferase activity
HPY17_07505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY17_07515	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY17_07545	COG0372	Belongs to the citrate synthase family
HPY17_07550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY17_07575	COG0583	DNA-binding transcription factor activity
HPY17_07580	COG4771	TonB-dependent receptor
HPY17_07605	COG1566	PFAM secretion protein HlyD family protein
HPY17_07625	COG1129	ABC transporter
HPY17_07650	COG0745	RESPONSE REGULATOR receiver
HPY17_07655	COG5002	protein histidine kinase activity
HPY17_07660	COG3713	MltA-interacting MipA family protein
HPY17_07665	COG2990	Protein conserved in bacteria
HPY17_07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY17_07675	COG4191	Histidine kinase
HPY17_07680	COG0471	metal ion transport
HPY17_07690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY17_07705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY17_07715	COG3768	UPF0283 membrane protein
HPY17_07720	COG3106	COG3106 Predicted ATPase
HPY17_07735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY17_07740	COG0494	nUDIX hydrolase
HPY17_07745	COG0814	amino acid
HPY17_07750	COG1760	l-serine dehydratase
HPY17_07755	COG0720	synthase
HPY17_07760	COG0840	transmembrane signaling receptor activity
HPY17_07765	COG0017	Asparaginyl-tRNA synthetase
HPY17_07770	COG0351	phosphomethylpyrimidine kinase
HPY17_07775	COG3437	response regulator, receiver
HPY17_07775	COG2770	Histidine kinase
HPY17_07780	COG1448	Aminotransferase
HPY17_07795	COG0840	transmembrane signaling receptor activity
HPY17_07800	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY17_07805	COG2943	transferase activity, transferring hexosyl groups
HPY17_07810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY17_07815	COG1846	Transcriptional regulator
HPY17_07840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY17_07855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY17_07860	COG3108	Peptidase M15
HPY17_07890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY17_07900	COG2814	Major facilitator Superfamily
HPY17_07920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY17_07925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY17_07930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY17_07960	COG0840	transmembrane signaling receptor activity
HPY17_07975	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY17_07980	COG4139	cobalamin transport
HPY17_07985	COG2988	succinylglutamate desuccinylase activity
HPY17_08000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY17_08005	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY17_08010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY17_08020	COG2925	Exonuclease
HPY17_08025	COG1380	Effector of murein hydrolase LrgA
HPY17_08030	COG1346	cytolysis
HPY17_08050	COG0500	methyltransferase
HPY17_08060	COG0776	regulation of translation
HPY17_08065	COG0072	phenylalanine-tRNA ligase activity
HPY17_08065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY17_08070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY17_08110	COG0322	excinuclease ABC activity
HPY17_08115	COG2197	response regulator
HPY17_08120	COG0417	DNA replication proofreading
HPY17_08125	COG5001	Diguanylate cyclase
HPY17_08135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY17_08140	COG3099	Belongs to the UPF0263 family
HPY17_08155	COG1228	amidohydrolase
HPY17_08160	COG0010	Belongs to the arginase family
HPY17_08165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY17_08170	COG2986	histidine ammonia-lyase
HPY17_08190	COG0277	FAD linked oxidase domain protein
HPY17_08190	COG0247	lactate metabolic process
HPY17_08205	COG2885	chlorophyll binding
HPY17_08225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY17_08235	COG0281	malic enzyme
HPY17_08245	COG2949	membrane
HPY17_08250	COG3706	GGDEF domain
HPY17_08255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY17_08265	COG0492	ferredoxin-NADP+ reductase activity
HPY17_08270	COG4988	ABC transporter
HPY17_08275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY17_08280	COG1187	pseudouridine synthase activity
HPY17_08285	COG0009	L-threonylcarbamoyladenylate synthase
HPY17_08290	COG0613	PHP domain protein
HPY17_08300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY17_08305	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY17_08310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY17_08315	COG0135	phosphoribosylanthranilate isomerase activity
HPY17_08315	COG0134	indole-3-glycerol-phosphate synthase activity
HPY17_08320	COG0133	tryptophan synthase activity
HPY17_08325	COG0159	tryptophan synthase activity
HPY17_08335	COG1435	thymidine kinase activity
HPY17_08340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY17_08350	COG4106	trans-aconitate 2-methyltransferase activity
HPY17_08355	COG0500	methyltransferase
HPY17_08360	COG0189	ligase activity
HPY17_08360	COG4067	protein conserved in archaea
HPY17_08375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY17_08385	COG3852	Histidine kinase
HPY17_08400	COG3070	regulator of competence-specific genes
HPY17_08410	COG2431	L-lysine efflux transmembrane transporter activity
HPY17_08420	COG0076	glutamate decarboxylase activity
HPY17_08425	COG1737	Transcriptional regulator
HPY17_08430	COG1012	belongs to the aldehyde dehydrogenase family
HPY17_08430	COG1454	alcohol dehydrogenase
HPY17_08435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY17_08440	COG3273	potassium ion transport
HPY17_08440	COG2985	domain, Protein
HPY17_08445	COG0542	response to heat
HPY17_08450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY17_08455	COG1278	Cold shock
HPY17_08465	COG1187	pseudouridine synthase activity
HPY17_08470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY17_08470	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY17_08475	COG0107	imidazoleglycerol-phosphate synthase activity
HPY17_08480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY17_08485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY17_08490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY17_08490	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY17_08495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY17_08500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY17_08505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY17_08510	COG1757	Na H antiporter
HPY17_08515	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY17_08520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY17_08525	COG0482	sulfurtransferase activity
HPY17_08530	COG2915	High frequency lysogenization protein hflD homolog
HPY17_08535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY17_08545	COG2268	Band 7 protein
HPY17_08555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY17_08570	COG0300	oxidoreductase activity
HPY17_08580	COG0501	Belongs to the peptidase M48B family
HPY17_08590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY17_08595	COG2226	methyltransferase
HPY17_08600	COG0156	8-amino-7-oxononanoate synthase activity
HPY17_08605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY17_08610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY17_08615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY17_08620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY17_08625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY17_08630	COG0653	protein targeting
HPY17_08635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY17_08640	COG3706	GGDEF domain
HPY17_08650	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY17_08660	COG4628	conserved protein (DUF2132)
HPY17_08665	COG3092	negative regulation of chromosome organization
HPY17_08670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY17_08675	COG0857	belongs to the CobB CobQ family
HPY17_08675	COG0280	phosphate acetyltransferase
HPY17_08680	COG0435	Glutathione S-transferase
HPY17_08685	COG4608	Belongs to the ABC transporter superfamily
HPY17_08690	COG0444	Belongs to the ABC transporter superfamily
HPY17_08695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY17_08700	COG0601	transmembrane transport
HPY17_08720	COG2204	response regulator
HPY17_08725	COG3300	MHYT domain
HPY17_08725	COG5001	Diguanylate cyclase
HPY17_08730	COG4191	Histidine kinase
HPY17_08735	COG5002	protein histidine kinase activity
HPY17_08745	COG2201	protein-glutamate methylesterase activity
HPY17_08760	COG0009	L-threonylcarbamoyladenylate synthase
HPY17_08775	COG1881	PFAM PEBP family protein
HPY17_08800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY17_08805	COG0640	Transcriptional regulator
HPY17_08855	COG1396	sequence-specific DNA binding
HPY17_08880	COG3706	GGDEF domain
HPY17_08900	COG1946	Acyl-CoA thioesterase
HPY17_08905	COG1522	sequence-specific DNA binding
HPY17_08915	COG0616	signal peptide processing
HPY17_08920	COG1028	Short-chain dehydrogenase reductase Sdr
HPY17_08925	COG2983	Belongs to the UPF0260 family
HPY17_08935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY17_08940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY17_08950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY17_08955	COG2832	Protein of unknown function (DUF454)
HPY17_08960	COG0745	RESPONSE REGULATOR receiver
HPY17_08965	COG0583	DNA-binding transcription factor activity
HPY17_08970	COG0778	Nitroreductase
HPY17_08975	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY17_08975	COG1024	Enoyl-CoA hydratase
HPY17_08980	COG0183	Belongs to the thiolase family
HPY17_08995	COG2067	long-chain fatty acid transport protein
HPY17_09005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY17_09010	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY17_09015	COG2982	Protein involved in outer membrane biogenesis
HPY17_09020	COG0572	uridine kinase
HPY17_09025	COG0489	protein tyrosine kinase activity
HPY17_09030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY17_09030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY17_09040	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY17_09050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY17_09050	COG0517	IMP dehydrogenase activity
HPY17_09050	COG0617	tRNA 3'-terminal CCA addition
HPY17_09055	COG2199	diguanylate cyclase activity
HPY17_09060	COG0314	molybdopterin synthase activity
HPY17_09065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY17_09070	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY17_09075	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY17_09080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY17_09085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY17_09090	COG2198	Histidine kinase
HPY17_09095	COG2204	response regulator
HPY17_09100	COG0556	nucleotide-excision repair
HPY17_09110	COG4657	Part of a membrane complex involved in electron transport
HPY17_09115	COG2878	Part of a membrane complex involved in electron transport
HPY17_09120	COG4656	Part of a membrane complex involved in electron transport
HPY17_09135	COG4660	Part of a membrane complex involved in electron transport
HPY17_09140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY17_09145	COG0346	lactoylglutathione lyase activity
HPY17_09160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY17_09165	COG2056	Na+-H+ antiporter family
HPY17_09170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY17_09175	COG1286	toxin biosynthetic process
HPY17_09180	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY17_09185	COG0285	dihydrofolate synthase activity
HPY17_09190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY17_09195	COG0101	tRNA pseudouridine synthase activity
HPY17_09210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY17_09210	COG1263	PTS System
HPY17_09210	COG2190	(PTS) system
HPY17_09215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY17_09220	COG1940	carbohydrate kinase activity
HPY17_09220	COG1846	Transcriptional regulator
HPY17_09225	COG4651	solute:proton antiporter activity
HPY17_09225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY17_09230	COG0367	asparagine synthase
HPY17_09245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY17_09250	COG0563	adenylate kinase activity
HPY17_09255	COG0326	Molecular chaperone. Has ATPase activity
HPY17_09260	COG3710	Transcriptional regulator
HPY17_09275	COG0622	Phosphoesterase
HPY17_09280	COG1090	epimerase
HPY17_09285	COG0300	oxidoreductase activity
HPY17_09290	COG3118	belongs to the thioredoxin family
HPY17_09295	COG0330	HflC and HflK could
HPY17_09300	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY17_09305	COG0789	Transcriptional regulator
HPY17_09320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY17_09325	COG3115	cell septum assembly
HPY17_09330	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY17_09335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY17_09340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY17_09350	COG2190	(PTS) system
HPY17_09355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY17_09360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY17_09365	COG1702	phosphate starvation-inducible protein PhoH
HPY17_09375	COG4535	Mg2 and Co2 transporter CorC
HPY17_09380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY17_09385	COG2888	peptidyl-tyrosine sulfation
HPY17_09390	COG0495	leucyl-tRNA aminoacylation
HPY17_09395	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY17_09400	COG1466	dna polymerase III delta subunit
HPY17_09405	COG0799	negative regulation of ribosome biogenesis
HPY17_09410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY17_09415	COG0768	penicillin binding
HPY17_09420	COG0772	Belongs to the SEDS family
HPY17_09425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY17_09430	COG1686	Belongs to the peptidase S11 family
HPY17_09435	COG2921	Belongs to the UPF0250 family
HPY17_09440	COG0321	lipoyl(octanoyl) transferase activity
HPY17_09445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY17_09455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY17_09480	COG1596	polysaccharide export
HPY17_09490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY17_09520	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY17_09530	COG0438	transferase activity, transferring glycosyl groups
HPY17_09540	COG1045	serine acetyltransferase
HPY17_09560	COG0110	maltose O-acetyltransferase activity
HPY17_09565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY17_09570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY17_09575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY17_09580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY17_09610	COG0366	Alpha amylase catalytic
HPY17_09615	COG1263	PTS System
HPY17_09615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY17_09620	COG1609	Transcriptional regulator
HPY17_09625	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY17_09630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY17_09635	COG2011	ABC-type metal ion transport system permease component
HPY17_09640	COG1464	Belongs to the NlpA lipoprotein family
HPY17_09645	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY17_09655	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY17_09655	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY17_09665	COG3706	GGDEF domain
HPY17_09670	COG1611	Belongs to the LOG family
HPY17_09675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY17_09680	COG2363	Small membrane protein
HPY17_09685	COG0583	DNA-binding transcription factor activity
HPY17_09690	COG0301	tRNA thio-modification
HPY17_09690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY17_09700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY17_09705	COG1722	exodeoxyribonuclease VII activity
HPY17_09710	COG0142	geranyltranstransferase activity
HPY17_09715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY17_09720	COG0564	pseudouridine synthase activity
HPY17_09725	COG3098	single-species biofilm formation
HPY17_09740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY17_09750	COG1671	Belongs to the UPF0178 family
HPY17_09755	COG3385	transposase activity
HPY17_09760	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY17_09765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY17_09770	COG0254	rRNA binding
HPY17_09775	COG1720	tRNA m6t6A37 methyltransferase activity
HPY17_09780	COG0442	prolyl-tRNA aminoacylation
HPY17_09800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY17_09800	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY17_09810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY17_09820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY17_09850	COG0484	heat shock protein binding
HPY17_09855	COG0443	Heat shock 70 kDa protein
HPY17_09860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY17_09865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY17_09870	COG0497	DNA recombination
HPY17_09875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY17_09880	COG2914	Belongs to the UPF0125 (RnfH) family
HPY17_09885	COG2867	negative regulation of translational initiation
HPY17_09890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY17_09900	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPY17_09905	COG0732	type I restriction modification DNA specificity domain
HPY17_09910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPY17_09925	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY17_09930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY17_09935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY17_09965	COG1115	amino acid carrier protein
HPY17_09970	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY17_09975	COG0583	DNA-binding transcription factor activity
HPY17_09985	COG1120	ATPase activity
HPY17_09990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY17_09995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY17_10000	COG4592	Periplasmic binding protein
HPY17_10010	COG1028	Short-chain dehydrogenase reductase Sdr
HPY17_10015	COG1169	isochorismate synthase
HPY17_10020	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY17_10025	COG1535	isochorismatase
HPY17_10025	COG3433	isochorismatase activity
HPY17_10030	COG1584	GPR1 FUN34 yaaH family protein
HPY17_10040	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY17_10050	COG0519	Catalyzes the synthesis of GMP from XMP
HPY17_10050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY17_10055	COG0516	GMP reductase activity
HPY17_10055	COG0517	IMP dehydrogenase activity
HPY17_10060	COG1570	exodeoxyribonuclease VII activity
HPY17_10075	COG1160	GTP binding
HPY17_10080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY17_10085	COG2976	Protein conserved in bacteria
HPY17_10090	COG0124	histidyl-tRNA synthetase
HPY17_10095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY17_10110	COG0105	UTP biosynthetic process
HPY17_10115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY17_10120	COG2975	iron-sulfur cluster assembly
HPY17_10125	COG0633	Ferredoxin
HPY17_10145	COG0822	iron-sulfur transferase activity
HPY17_10150	COG1104	cysteine desulfurase activity
HPY17_10155	COG1959	2 iron, 2 sulfur cluster binding
HPY17_10165	COG0483	inositol monophosphate 1-phosphatase activity
HPY17_10170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY17_10175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY17_10180	COG1862	Preprotein translocase
HPY17_10190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY17_10195	COG0517	IMP dehydrogenase activity
HPY17_10205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY17_10210	COG0583	DNA-binding transcription factor activity
HPY17_10215	COG0450	alkyl hydroperoxide reductase
HPY17_10220	COG3142	Participates in the control of copper homeostasis
HPY17_10235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY17_10240	COG0581	inorganic phosphate transmembrane transporter activity
HPY17_10250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY17_10255	COG0248	Ppx GppA phosphatase
HPY17_10265	COG5002	protein histidine kinase activity
HPY17_10270	COG0745	RESPONSE REGULATOR receiver
HPY17_10285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY17_10330	COG0542	response to heat
HPY17_10340	COG0564	pseudouridine synthase activity
HPY17_10345	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY17_10350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY17_10355	COG1605	Chorismate mutase
HPY17_10355	COG0077	Prephenate dehydratase
HPY17_10360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY17_10365	COG5001	Diguanylate cyclase
HPY17_10375	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY17_10385	COG0488	(ABC) transporter
HPY17_10395	COG1605	Chorismate mutase
HPY17_10395	COG0287	Prephenate dehydrogenase
HPY17_10400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY17_10405	COG3275	phosphorelay sensor kinase activity
HPY17_10410	COG3279	Response regulator of the LytR AlgR family
HPY17_10420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY17_10425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY17_10440	COG1966	Carbon starvation protein
HPY17_10445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY17_10450	COG1047	Peptidyl-prolyl cis-trans
HPY17_10455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY17_10465	COG0196	riboflavin kinase activity
HPY17_10470	COG0728	peptidoglycan biosynthetic process
HPY17_10475	COG0268	Binds directly to 16S ribosomal RNA
HPY17_10480	COG0640	Transcriptional regulator
HPY17_10485	COG0583	DNA-binding transcription factor activity
HPY17_10490	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY17_10500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY17_10505	COG0730	response to heat
HPY17_10510	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY17_10515	COG0494	nUDIX hydrolase
HPY17_10525	COG0667	Aldo Keto reductase
HPY17_10535	COG2204	response regulator
HPY17_10540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY17_10560	COG0513	Belongs to the DEAD box helicase family
HPY17_10585	COG3153	acetyltransferase
HPY17_10590	COG3154	lipid carrier protein
HPY17_10600	COG0826	peptidase U32
HPY17_10605	COG0826	peptidase U32
HPY17_10620	COG3385	transposase activity
HPY17_10635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY17_10645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY17_10650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY17_10655	COG0195	Participates in both transcription termination and antitermination
HPY17_10660	COG0779	Required for maturation of 30S ribosomal subunits
HPY17_10675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY17_10685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY17_10690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY17_10695	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY17_10700	COG1534	Rna-binding protein
HPY17_10705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY17_10710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY17_10715	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY17_10720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY17_10725	COG0739	heme binding
HPY17_10740	COG0316	Belongs to the HesB IscA family
HPY17_10745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY17_10750	COG0628	permease
HPY17_10755	COG2813	Specifically methylates the guanine in position
HPY17_10765	COG0747	negative chemotaxis
HPY17_10775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY17_10780	COG0444	Belongs to the ABC transporter superfamily
HPY17_10785	COG4608	Belongs to the ABC transporter superfamily
HPY17_10795	COG2971	BadF BadG BcrA BcrD
HPY17_10815	COG3842	ATPase activity
HPY17_10825	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY17_10830	COG0004	ammonium transporteR
HPY17_10835	COG0347	Belongs to the P(II) protein family
HPY17_10840	COG3112	Uncharacterised protein family (UPF0231)
HPY17_10845	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY17_10850	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY17_10855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY17_10860	COG1643	Atp-dependent helicase
HPY17_10870	COG1489	DNA binding
HPY17_10880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY17_10890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY17_10895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY17_10900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY17_10905	COG0842	Transport permease protein
HPY17_10910	COG1131	(ABC) transporter
HPY17_10915	COG0659	secondary active sulfate transmembrane transporter activity
HPY17_10920	COG0288	reversible hydration of carbon dioxide
HPY17_10935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY17_10940	COG3107	peptidoglycan biosynthetic process
HPY17_10945	COG0792	nuclease activity
HPY17_10950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY17_10955	COG2823	Periplasmic or secreted lipoprotein
HPY17_10960	COG2969	positive regulation of protein catabolic process
HPY17_10965	COG0625	glutathione transferase activity
HPY17_10970	COG2857	Cytochrome c1
HPY17_10975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY17_10980	COG0723	plastoquinol--plastocyanin reductase activity
HPY17_10985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY17_10990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY17_10995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY17_11005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY17_11010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY17_11015	COG0335	large ribosomal subunit rRNA binding
HPY17_11020	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY17_11025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY17_11030	COG0228	four-way junction DNA binding
HPY17_11035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY17_11040	COG4137	Cytochrome C assembly protein
HPY17_11045	COG4536	flavin adenine dinucleotide binding
HPY17_11050	COG1854	S-ribosylhomocysteine lyase activity
HPY17_11055	COG2918	glutathione biosynthetic process
HPY17_11060	COG0612	Peptidase, M16
HPY17_11065	COG1238	metal cluster binding
HPY17_11075	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY17_11080	COG5016	pyruvate
HPY17_11080	COG0511	ligase activity, forming carbon-carbon bonds
HPY17_11085	COG3630	sodium ion export across plasma membrane
HPY17_11130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY17_11135	COG0527	aspartate kinase activity
HPY17_11140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY17_11145	COG2137	regulation of response to DNA damage stimulus
HPY17_11150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY17_11160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY17_11165	COG4208	sulfate ABC transporter
HPY17_11185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY17_11190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY17_11200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY17_11205	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY17_11210	COG0585	pseudouridine synthase activity
HPY17_11215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY17_11220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY17_11225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY17_11230	COG1968	undecaprenyl-diphosphatase activity
HPY17_11235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY17_11240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY17_11245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY17_11255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY17_11260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY17_11265	COG1610	YqeY-like protein
HPY17_11290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY17_11295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY17_11300	COG1349	DNA-binding transcription factor activity
HPY17_11320	COG1279	arginine transmembrane transporter activity
HPY17_11325	COG0668	transmembrane transport
HPY17_11330	COG0191	fructose-bisphosphate aldolase activity
HPY17_11335	COG0126	phosphoglycerate kinase activity
HPY17_11340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY17_11345	COG4771	TonB-dependent receptor
HPY17_11350	COG0583	DNA-binding transcription factor activity
HPY17_11355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY17_11360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY17_11365	COG3091	SprT-like family
HPY17_11370	COG2356	endonuclease I
HPY17_11375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY17_11380	COG0189	ligase activity
HPY17_11385	COG1678	Uncharacterized ACR, COG1678
HPY17_11390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY17_11395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY17_11415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY17_11420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY17_11425	COG0762	integral membrane protein
HPY17_11440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY17_11445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY17_11450	COG2066	Belongs to the glutaminase family
HPY17_11455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY17_11460	COG1194	a g-specific adenine glycosylase
HPY17_11465	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY17_11470	COG0741	lytic transglycosylase activity
HPY17_11525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY17_11530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY17_11535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY17_11540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY17_11545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY17_11550	COG2967	ApaG domain
HPY17_11555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY17_11565	COG3610	response to peptide
HPY17_11570	COG2966	Psort location CytoplasmicMembrane, score
HPY17_11575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY17_11580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY17_11585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY17_11590	COG0142	geranyltranstransferase activity
HPY17_11595	COG0531	amino acid
HPY17_11600	COG0039	L-malate dehydrogenase activity
HPY17_11605	COG1438	arginine binding
HPY17_11610	COG2358	TRAP transporter, solute receptor (TAXI family
HPY17_11620	COG0589	response to stress
HPY17_11640	COG2235	arginine
HPY17_11645	COG0312	modulator of DNA gyrase
HPY17_11650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY17_11655	COG3164	Protein of unknown function
HPY17_11660	COG1530	ribonuclease E activity
HPY17_11665	COG0424	maF-like protein
HPY17_11670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY17_11675	COG1792	Involved in formation and maintenance of cell shape
HPY17_11680	COG1077	Cell shape determining protein MreB Mrl
HPY17_11725	COG1459	type II secretion system
HPY17_11730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY17_11740	COG3409	Peptidoglycan-binding domain 1 protein
HPY17_11740	COG3267	Type II secretory pathway component ExeA
HPY17_11765	COG2200	EAL domain
HPY17_11765	COG2199	diguanylate cyclase activity
HPY17_11770	COG0629	single-stranded DNA binding
HPY17_11785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY17_11795	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY17_11800	COG0527	aspartate kinase activity
HPY17_11880	COG0175	sulfate reduction
HPY17_11890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY17_11915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY17_11920	COG0735	belongs to the Fur family
HPY17_11935	COG0166	Belongs to the GPI family
HPY17_11940	COG0432	Pfam Uncharacterised protein family UPF0047
HPY17_11945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY17_11960	COG0359	binds to the 23S rRNA
HPY17_11965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY17_11970	COG2965	DNA replication, synthesis of RNA primer
HPY17_11975	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY17_11985	COG2906	2 iron, 2 sulfur cluster binding
HPY17_11990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY17_11995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY17_12000	COG0049	tRNA binding
HPY17_12015	COG2923	Belongs to the DsrF TusC family
HPY17_12020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY17_12025	COG2964	Protein conserved in bacteria
HPY17_12030	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY17_12040	COG2900	Belongs to the SlyX family
HPY17_12045	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY17_12050	COG0330	HflC and HflK could
HPY17_12055	COG0330	HflC and HflK could
HPY17_12060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY17_12065	COG1923	regulation of RNA biosynthetic process
HPY17_12070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY17_12075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY17_12085	COG0802	atpase or kinase
HPY17_12090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY17_12135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY17_12140	COG1162	GTPase activity
HPY17_12145	COG0688	phosphatidylethanolamine metabolic process
HPY17_12150	COG0471	metal ion transport
HPY17_12160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY17_12165	COG4942	peptidase
HPY17_12180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY17_12185	COG2816	NAD+ diphosphatase activity
HPY17_12190	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY17_12195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY17_12200	COG0085	RNA polymerase activity
HPY17_12205	COG0222	ribosome binding
HPY17_12210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY17_12220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY17_12225	COG0250	Participates in transcription elongation, termination and antitermination
HPY17_12230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY17_12235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY17_12260	COG1072	(Pantothenic acid kinase))
HPY17_12270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY17_12280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY17_12325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY17_12340	COG3118	belongs to the thioredoxin family
HPY17_12345	COG0513	Belongs to the DEAD box helicase family
HPY17_12350	COG0248	Ppx GppA phosphatase
HPY17_12355	COG2205	protein histidine kinase activity
HPY17_12355	COG0784	Response regulator, receiver
HPY17_12360	COG2814	Major facilitator Superfamily
HPY17_12375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY17_12380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY17_12385	COG0511	ligase activity, forming carbon-carbon bonds
HPY17_12390	COG0439	Biotin carboxylase
HPY17_12395	COG2264	protein methyltransferase activity
HPY17_12400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY17_12405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY17_12415	COG1609	Transcriptional regulator
HPY17_12425	COG0129	dihydroxy-acid dehydratase activity
HPY17_12430	COG3265	gluconokinase activity
HPY17_12435	COG2610	gluconate transmembrane transporter activity
HPY17_12440	COG0800	Aldolase
HPY17_12460	COG0840	transmembrane signaling receptor activity
HPY17_12465	COG1982	Orn Lys Arg decarboxylase major
HPY17_12470	COG0531	amino acid
HPY17_12475	COG3710	Transcriptional regulator
HPY17_12480	COG0789	Transcriptional regulator
HPY17_12495	COG0151	Belongs to the GarS family
HPY17_12505	COG0776	regulation of translation
HPY17_12510	COG1253	flavin adenine dinucleotide binding
HPY17_12525	COG3068	Protein conserved in bacteria
HPY17_12535	COG1573	uracil-dna glycosylase
HPY17_12540	COG0668	transmembrane transport
HPY17_12545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY17_12555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPY17_12560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPY17_12565	COG1482	cell wall glycoprotein biosynthetic process
HPY17_12590	COG0438	transferase activity, transferring glycosyl groups
HPY17_12605	COG1216	Glycosyl transferase, family 2
HPY17_12645	COG1596	polysaccharide export
HPY17_12665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY17_12675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY17_12700	COG1215	transferase activity, transferring glycosyl groups
HPY17_12705	COG1132	(ABC) transporter
HPY17_12740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY17_12760	COG0859	PFAM glycosyl transferase family 9
HPY17_12770	COG1519	Transferase
HPY17_12775	COG0456	acetyltransferase
HPY17_12780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY17_12795	COG3642	lipopolysaccharide core region biosynthetic process
HPY17_12800	COG0859	PFAM glycosyl transferase family 9
HPY17_12805	COG0463	Glycosyl transferase, family 2
HPY17_12810	COG0859	PFAM glycosyl transferase family 9
HPY17_12815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY17_12820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY17_12830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY17_12835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY17_12840	COG2003	Belongs to the UPF0758 family
HPY17_12845	COG0840	transmembrane signaling receptor activity
HPY17_12850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY17_12860	COG1309	transcriptional regulator
HPY17_12865	COG1560	Kdo2-lipid A biosynthetic process
HPY17_12870	COG1560	Kdo2-lipid A biosynthetic process
HPY17_12875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY17_12880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY17_12885	COG1561	YicC-like family, N-terminal region
HPY17_12940	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPY17_12990	COG2862	Uncharacterized protein family, UPF0114
HPY17_12995	COG3385	transposase activity
HPY17_13000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY17_13005	COG1263	PTS System
HPY17_13005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY17_13010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY17_13025	COG0514	ATP-dependent DNA helicase (RecQ)
HPY17_13030	COG2962	Rard protein
HPY17_13035	COG0405	Gamma-glutamyltransferase
HPY17_13045	COG1280	lysine exporter protein (LysE YggA)
HPY17_13050	COG0210	DNA helicase
HPY17_13060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY17_13065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY17_13075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY17_13085	COG0747	negative chemotaxis
HPY17_13180	COG4964	Belongs to the GSP D family
HPY17_13215	COG1309	transcriptional regulator
HPY17_13220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY17_13225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY17_13230	COG2960	long-chain fatty acid transporting porin activity
HPY17_13235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY17_13240	COG0583	DNA-binding transcription factor activity
HPY17_13305	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY17_13310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY17_13315	COG1739	Uncharacterized protein family UPF0029
HPY17_13320	COG1024	Enoyl-CoA hydratase
HPY17_13320	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY17_13325	COG0183	Belongs to the thiolase family
HPY17_13330	COG0583	DNA-binding transcription factor activity
HPY17_13335	COG2814	Major facilitator Superfamily
HPY17_13345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY17_13350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY17_13355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY17_13360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY17_13365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY17_13370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY17_13380	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY17_13385	COG3312	ion transport
HPY17_13390	COG1475	DNA binding
HPY17_13395	COG1192	Involved in chromosome partitioning
HPY17_13400	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY17_13405	COG0445	tRNA wobble uridine modification
HPY17_13410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY17_13505	COG4974	Belongs to the 'phage' integrase family
HPY17_13510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY17_13515	COG0706	membrane insertase activity
HPY17_13525	COG0594	ribonuclease P activity
HPY17_13530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY17_13535	COG1126	abc transporter atp-binding protein
HPY17_13580	COG0217	transcriptional regulatory protein
HPY17_13585	COG2084	Dehydrogenase
HPY17_13600	COG2909	trisaccharide binding
HPY17_13605	COG0058	SHG alpha-glucan phosphorylase activity
HPY17_13610	COG1640	4-alpha-glucanotransferase
HPY17_13615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY17_13625	COG3501	Rhs element vgr protein
HPY17_13660	COG0471	metal ion transport
HPY17_13665	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY17_13695	COG0671	phosphoesterase, PA-phosphatase related
HPY17_13705	COG3385	transposase activity
HPY17_13710	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY17_13720	COG1999	signal sequence binding
HPY17_13735	COG0786	glutamate:sodium symporter activity
HPY17_13755	COG1566	PFAM secretion protein HlyD family protein
HPY17_13765	COG3706	GGDEF domain
HPY17_13780	COG0813	purine-nucleoside phosphorylase activity
HPY17_13785	COG3272	Protein of unknown function (DUF1722)
HPY17_13795	COG0415	Belongs to the DNA photolyase family
HPY17_13800	COG1376	ErfK ybiS ycfS ynhG family protein
HPY17_13800	COG1388	LysM domain
HPY17_13810	COG0513	Belongs to the DEAD box helicase family
HPY17_13815	COG1770	oligopeptidase
HPY17_13845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY17_13850	COG0573	inorganic phosphate transmembrane transporter activity
HPY17_13855	COG0581	inorganic phosphate transmembrane transporter activity
HPY17_13860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY17_13880	COG0659	secondary active sulfate transmembrane transporter activity
HPY17_13890	COG0739	heme binding
HPY17_13895	COG3300	MHYT domain
HPY17_13895	COG5001	Diguanylate cyclase
HPY17_13900	COG0583	DNA-binding transcription factor activity
HPY17_13905	COG2814	Major facilitator Superfamily
HPY17_13925	COG1301	dicarboxylic acid transport
HPY17_13940	COG1342	Belongs to the UPF0251 family
HPY17_13970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY17_13975	COG0673	inositol 2-dehydrogenase activity
HPY17_13985	COG2771	luxR family
HPY17_13985	COG2200	EAL domain
HPY17_13990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY17_14000	COG0564	pseudouridine synthase activity
HPY17_14105	COG1869	D-ribose catabolic process
HPY17_14110	COG1129	ABC transporter
HPY17_14115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY17_14120	COG1879	ABC-type sugar transport system periplasmic component
HPY17_14125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY17_14130	COG1609	Transcriptional regulator
HPY17_14140	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY17_14150	COG0584	glycerophosphoryl diester phosphodiesterase
HPY17_14155	COG2271	Major facilitator Superfamily
HPY17_14190	COG0579	oxidoreductase
HPY17_14200	COG0242	peptide deformylase activity
HPY17_14205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY17_14205	COG1017	nitric oxide dioxygenase activity
HPY17_14210	COG1320	monovalent cation:proton antiporter activity
HPY17_14215	COG2212	antiporter activity
HPY17_14235	COG2111	Na H antiporter
HPY17_14235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY17_14245	COG0589	response to stress
HPY17_14250	COG0814	amino acid
HPY17_14265	COG3530	Putative quorum-sensing-regulated virulence factor
HPY17_14275	COG5002	protein histidine kinase activity
HPY17_14275	COG5001	Diguanylate cyclase
HPY17_14280	COG1278	Cold shock
HPY17_14295	COG2304	oxidoreductase activity
HPY17_14315	COG0714	Associated with various cellular activities
HPY17_14320	COG0840	transmembrane signaling receptor activity
HPY17_14335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY17_14340	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY17_14350	COG3604	Transcriptional regulator
HPY17_14355	COG1017	nitric oxide dioxygenase activity
HPY17_14355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY17_14360	COG1278	Cold shock
HPY17_14365	COG3036	rescue of stalled ribosome
HPY17_14390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY17_14390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY17_14395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY17_14405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY17_14415	COG0516	GMP reductase activity
HPY17_14420	COG1204	response to ionizing radiation
HPY17_14430	COG0513	Belongs to the DEAD box helicase family
HPY17_14435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY17_14440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY17_14450	COG0784	Response regulator, receiver
HPY17_14450	COG3437	response regulator, receiver
HPY17_14455	COG4191	Histidine kinase
HPY17_14455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY17_14465	COG1757	Na H antiporter
HPY17_14470	COG2814	Major facilitator Superfamily
HPY17_14480	COG3706	GGDEF domain
HPY17_14485	COG3240	lipase activity
HPY17_14500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY17_14505	COG5380	lipid catabolic process
HPY17_14530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY17_14535	COG4605	iron ion homeostasis
HPY17_14540	COG4604	ABC transporter, ATP-binding protein
HPY17_14545	COG2207	Transcriptional regulator
HPY17_14560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY17_14575	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY17_14585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY17_14595	COG0583	DNA-binding transcription factor activity
HPY17_14610	COG0745	RESPONSE REGULATOR receiver
HPY17_14620	COG3623	hexulose-6-phosphate isomerase
HPY17_14625	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY17_14630	COG0561	phosphatase activity
HPY17_14665	COG0366	Alpha amylase catalytic
HPY17_14685	COG0745	RESPONSE REGULATOR receiver
HPY17_14690	COG5002	protein histidine kinase activity
HPY17_14735	COG1686	Belongs to the peptidase S11 family
HPY17_14755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY17_14755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY17_14760	COG0509	glycine decarboxylation via glycine cleavage system
HPY17_14765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY17_14775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY17_14790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY17_14795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY17_14920	COG0384	phenazine biosynthesis protein PhzF
HPY17_15045	COG0384	phenazine biosynthesis protein PhzF
HPY17_15055	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY17_15135	COG1028	Short-chain dehydrogenase reductase Sdr
HPY17_15260	COG3041	Addiction module toxin RelE StbE family
HPY17_15270	COG0384	phenazine biosynthesis protein PhzF
HPY17_15275	COG0346	lactoylglutathione lyase activity
HPY17_15320	COG3171	Protein conserved in bacteria
HPY17_15385	COG0384	phenazine biosynthesis protein PhzF
HPY17_15665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY17_15860	COG0346	lactoylglutathione lyase activity
HPY17_15885	COG3040	lipid binding
HPY17_15900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY17_16005	COG0456	acetyltransferase
HPY17_16050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY17_16050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY17_16055	COG0494	nUDIX hydrolase
HPY17_16080	COG1028	Short-chain dehydrogenase reductase Sdr
HPY17_16095	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY17_16130	COG0384	phenazine biosynthesis protein PhzF
HPY17_16290	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY17_16315	COG0384	phenazine biosynthesis protein PhzF
HPY17_16325	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY17_16330	COG2944	sequence-specific DNA binding
HPY17_16395	COG0346	lactoylglutathione lyase activity
HPY17_16430	COG0384	phenazine biosynthesis protein PhzF
HPY17_16455	COG5642	Protein of unknown function (DUF2384)
HPY17_16460	COG0384	phenazine biosynthesis protein PhzF
HPY17_16480	COG0494	nUDIX hydrolase
HPY17_16485	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY17_16495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY17_16495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY17_16525	COG3040	lipid binding
HPY17_16575	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY17_16585	COG0840	transmembrane signaling receptor activity
HPY17_16590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY17_16595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY17_16600	COG1621	beta-fructofuranosidase activity
HPY17_16610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY17_16610	COG1263	PTS System
HPY17_16655	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY17_16690	COG0778	Nitroreductase
HPY17_16695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY17_16700	COG0583	DNA-binding transcription factor activity
HPY17_16725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY17_16760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY17_16770	COG2390	Transcriptional regulator
HPY17_16780	COG2897	thiosulfate sulfurtransferase activity
HPY17_16790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY17_16800	COG0302	gtp cyclohydrolase
HPY17_16805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY17_16805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY17_16810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY17_16815	COG1970	mechanosensitive ion channel activity
HPY17_16820	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY17_16830	COG1011	Hydrolase
HPY17_16835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY17_16840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY17_16850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY17_16860	COG3842	ATPase activity
HPY17_16880	COG3104	oligopeptide transport
HPY17_16905	COG4166	transmembrane transport
HPY17_16910	COG4174	ABC transporter (Permease)
HPY17_16915	COG4239	(ABC) transporter, permease
HPY17_16920	COG4172	Belongs to the ABC transporter superfamily
HPY17_16925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY17_16940	COG0625	glutathione transferase activity
HPY17_16960	COG2050	protein possibly involved in aromatic compounds catabolism
HPY17_16975	COG4771	TonB-dependent receptor
HPY17_16975	COG1629	transport
HPY17_16980	COG0583	DNA-binding transcription factor activity
HPY17_16985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY17_16985	COG1042	CoA-binding domain protein
HPY17_16985	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY17_17005	COG0023	Translation Initiation Factor
HPY17_17010	COG3140	Belongs to the UPF0181 family
HPY17_17025	COG0745	RESPONSE REGULATOR receiver
HPY17_17035	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY17_17040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY17_17055	COG3706	GGDEF domain
HPY17_17110	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY17_17115	COG3385	transposase activity
HPY17_17130	COG0737	Belongs to the 5'-nucleotidase family
HPY17_17135	COG3593	DNA synthesis involved in DNA repair
HPY17_17145	COG0583	DNA-binding transcription factor activity
HPY17_17150	COG2116	formate transmembrane transporter activity
HPY17_17160	COG3038	cytochrome b561
HPY17_17170	COG2200	EAL domain
HPY17_17185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY17_17190	COG0745	RESPONSE REGULATOR receiver
HPY17_17195	COG2205	protein histidine kinase activity
HPY17_17200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY17_17200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY17_17200	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY17_17200	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY17_17205	COG3158	transport of potassium into the cell
HPY17_17215	COG0523	cobalamin synthesis protein
HPY17_17220	COG0038	chloride channel
HPY17_17230	COG0156	8-amino-7-oxononanoate synthase activity
HPY17_17235	COG0784	Response regulator, receiver
HPY17_17235	COG2205	protein histidine kinase activity
HPY17_17240	COG0419	ATPase involved in DNA repair
HPY17_17245	COG0420	3'-5' exonuclease activity
HPY17_17250	COG1609	Transcriptional regulator
HPY17_17255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY17_17255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY17_17260	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY17_17265	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY17_17265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY17_17265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY17_17270	COG4067	protein conserved in archaea
HPY17_17270	COG0189	ligase activity
HPY17_17280	COG0602	queuosine metabolic process
HPY17_17285	COG1328	CTP reductase activity
HPY17_17295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY17_17300	COG0840	transmembrane signaling receptor activity
HPY17_17305	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY17_17310	COG1760	l-serine dehydratase
HPY17_17315	COG2197	response regulator
HPY17_17320	COG3850	Histidine kinase
HPY17_17325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY17_17335	COG0243	molybdopterin cofactor binding
HPY17_17355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY17_17360	COG2197	response regulator
HPY17_17365	COG3851	Histidine kinase
HPY17_17370	COG2271	Major facilitator Superfamily
HPY17_17375	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY17_17385	COG3842	ATPase activity
HPY17_17390	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY17_17400	COG0183	Belongs to the thiolase family
HPY17_17410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY17_17415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY17_17430	COG3706	GGDEF domain
HPY17_17435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY17_17445	COG1979	alcohol dehydrogenase
HPY17_17460	COG4191	Histidine kinase
HPY17_17470	COG2271	Major facilitator Superfamily
HPY17_17475	COG0469	pyruvate kinase activity
HPY17_17485	COG1879	ABC-type sugar transport system periplasmic component
HPY17_17490	COG1803	Methylglyoxal synthase
HPY17_17495	COG1335	isochorismatase
HPY17_17500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY17_17505	COG0210	DNA helicase
HPY17_17510	COG1289	transmembrane transporter activity
HPY17_17540	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY17_17545	COG4149	molybdate abc transporter
HPY17_17550	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY17_17555	COG1492	cobalamin metabolic process
HPY17_17595	COG1917	Cupin 2, conserved barrel domain protein
HPY17_17595	COG4977	sequence-specific DNA binding
HPY17_17605	COG2814	Major facilitator Superfamily
HPY17_17610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY17_17610	COG2226	methyltransferase
HPY17_17610	COG3433	isochorismatase activity
HPY17_17635	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY17_17640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY17_17660	COG1132	(ABC) transporter
HPY17_17665	COG1132	(ABC) transporter
HPY17_17675	COG0784	Response regulator, receiver
HPY17_17675	COG5002	protein histidine kinase activity
HPY17_17680	COG1879	ABC-type sugar transport system periplasmic component
HPY17_17690	COG2827	Endonuclease containing a URI domain
HPY17_17705	COG2926	Belongs to the UPF0265 family
HPY17_17715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY17_17720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY17_17725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY17_17730	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPY17_17735	COG0247	lactate metabolic process
HPY17_17740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY17_17745	COG3118	belongs to the thioredoxin family
HPY17_17770	COG4160	amino acid transport
HPY17_17775	COG4215	(ABC) transporter
HPY17_17780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY17_17785	COG1126	abc transporter atp-binding protein
HPY17_17795	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY17_17805	COG0494	nUDIX hydrolase
HPY17_17810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY17_17820	COG1309	transcriptional regulator
HPY17_17825	COG0513	Belongs to the DEAD box helicase family
HPY17_17830	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY17_17835	COG0814	amino acid
HPY17_17840	COG0840	transmembrane signaling receptor activity
HPY17_17845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY17_17850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY17_17860	COG1984	allophanate hydrolase subunit 2
HPY17_17875	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY17_17880	COG4181	ATPase activity
HPY17_17890	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY17_17895	COG1716	ATPase activity
HPY17_17895	COG5001	Diguanylate cyclase
HPY17_17905	COG0484	heat shock protein binding
HPY17_17920	COG0546	phosphoglycolate phosphatase activity
HPY17_17935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY17_17940	COG1368	sulfuric ester hydrolase activity
HPY17_17950	COG0513	Belongs to the DEAD box helicase family
HPY17_17965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY17_17975	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY17_17980	COG3397	chitin binding
HPY17_17985	COG3227	Zinc metalloprotease (Elastase)
HPY17_18000	COG1166	arginine decarboxylase activity
HPY17_18010	COG2239	Acts as a magnesium transporter
HPY17_18020	COG0527	aspartate kinase activity
HPY17_18030	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY17_18035	COG3186	Phenylalanine-4-hydroxylase
HPY17_18040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY17_18055	COG2264	protein methyltransferase activity
HPY17_18080	COG1253	flavin adenine dinucleotide binding
HPY17_18085	COG1765	OsmC-like protein
HPY17_18110	COG0531	amino acid
HPY17_18115	COG3706	GGDEF domain
HPY17_18125	COG4989	oxidoreductase activity
HPY17_18130	COG0366	Alpha amylase catalytic
HPY17_18140	COG2067	long-chain fatty acid transport protein
HPY17_18145	COG2267	carboxylic ester hydrolase activity
HPY17_18155	COG3227	Zinc metalloprotease (Elastase)
HPY17_18160	COG3047	cAMP biosynthetic process
HPY17_18170	COG1686	Belongs to the peptidase S11 family
HPY17_18175	COG0557	exoribonuclease II activity
HPY17_18180	COG1278	Cold shock
HPY17_18190	COG3048	D-serine ammonia-lyase activity
HPY17_18195	COG0583	DNA-binding transcription factor activity
HPY17_18215	COG2801	Transposase and inactivated derivatives
HPY17_18220	COG5002	protein histidine kinase activity
HPY17_18245	COG0582	viral genome integration into host DNA
HPY17_18265	COG1063	alcohol dehydrogenase
HPY17_18270	COG0156	8-amino-7-oxononanoate synthase activity
HPY17_18275	COG2873	o-acetylhomoserine
HPY17_18285	COG0346	lactoylglutathione lyase activity
HPY17_18310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY17_18320	COG0363	glucosamine-6-phosphate deaminase activity
HPY17_18325	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY17_18360	COG1929	Belongs to the glycerate kinase type-1 family
HPY17_18365	COG2610	gluconate transmembrane transporter activity
HPY17_18370	COG3835	regulator
HPY17_18380	COG0748	coenzyme F420 binding
HPY17_18385	COG3721	Heme iron utilization protein
HPY17_18395	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY17_18400	COG0811	peptide transport
HPY17_18405	COG0848	biopolymer transport protein
HPY17_18410	COG4558	Periplasmic binding protein
HPY17_18415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY17_18420	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY17_18460	COG0418	dihydroorotase activity
HPY17_18465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY17_18470	COG2354	Protein conserved in bacteria
HPY17_18480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY17_18485	COG1278	Cold shock
HPY17_18500	COG4753	response regulator
HPY17_18500	COG2207	Transcriptional regulator
HPY17_18510	COG3706	GGDEF domain
HPY17_18515	COG1349	DNA-binding transcription factor activity
HPY17_18530	COG3833	ABC-type maltose transport systems, permease component
HPY17_18535	COG1175	transmembrane transport
HPY17_18545	COG3842	ATPase activity
HPY17_18550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY17_18565	COG0393	Putative heavy-metal-binding
HPY17_18575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY17_18580	COG0784	Response regulator, receiver
HPY17_18580	COG0835	chemotaxis
HPY17_18585	COG1846	Transcriptional regulator
HPY17_18590	COG3706	GGDEF domain
HPY17_18625	COG0583	DNA-binding transcription factor activity
HPY17_18630	COG5001	Diguanylate cyclase
HPY17_18640	COG1741	Belongs to the pirin family
HPY17_18645	COG3123	guanosine phosphorylase activity
HPY17_18655	COG2211	Major facilitator Superfamily
HPY17_18665	COG1067	ATP-dependent peptidase activity
HPY17_18675	COG4172	Belongs to the ABC transporter superfamily
HPY17_18695	COG0583	DNA-binding transcription factor activity
HPY17_18705	COG1620	l-lactate permease
HPY17_18720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY17_18730	COG0840	transmembrane signaling receptor activity
HPY17_18750	COG2258	MOSC domain
HPY17_18755	COG0513	Belongs to the DEAD box helicase family
HPY17_18765	COG2186	Transcriptional regulator
HPY17_18775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY17_18785	COG0246	Mannitol dehydrogenase
HPY17_18790	COG1904	glucuronate isomerase
HPY17_18795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY17_18800	COG0800	Aldolase
HPY17_18810	COG0583	DNA-binding transcription factor activity
HPY17_18820	COG1902	pentaerythritol trinitrate reductase activity
HPY17_18830	COG1132	(ABC) transporter
HPY17_18840	COG1902	pentaerythritol trinitrate reductase activity
HPY17_18850	COG1280	lysine exporter protein (LysE YggA)
HPY17_18855	COG2207	Transcriptional regulator
HPY17_18875	COG1846	Transcriptional regulator
HPY17_18880	COG1764	response to oxidative stress
HPY17_18885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY17_18890	COG0697	spore germination
HPY17_18900	COG0700	Nucleoside recognition
HPY17_18905	COG3366	ferrous iron transmembrane transporter activity
HPY17_18910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY17_18920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY17_18925	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY17_18930	COG2259	Doxx family
HPY17_18955	COG0363	glucosamine-6-phosphate deaminase activity
HPY17_18970	COG4580	involved in the transport of maltose and maltodextrins
HPY17_18985	COG0840	transmembrane signaling receptor activity
HPY17_18995	COG0840	transmembrane signaling receptor activity
HPY17_19000	COG3706	GGDEF domain
HPY17_19010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY17_19015	COG1126	abc transporter atp-binding protein
HPY17_19025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY17_19030	COG4597	amino acid ABC transporter
HPY17_19035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY17_19040	COG2213	PTS system mannitol-specific
HPY17_19040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY17_19045	COG0246	Mannitol dehydrogenase
HPY17_19050	COG3722	fumarate hydratase activity
HPY17_19085	COG2910	NAD(P)H-binding
HPY17_19095	COG0840	transmembrane signaling receptor activity
HPY17_19100	COG4221	oxidoreductase activity
HPY17_19110	COG1901	pseudouridine methyltransferase
HPY17_19125	COG0531	amino acid
HPY17_19130	COG1982	Orn Lys Arg decarboxylase major
HPY17_19140	COG2197	response regulator
HPY17_19190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY17_19215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY17_19280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY17_19285	COG0840	transmembrane signaling receptor activity
HPY17_19290	COG0835	chemotaxis
HPY17_19295	COG0835	chemotaxis
HPY17_19300	COG0643	Histidine kinase
HPY17_19300	COG2198	Histidine kinase
HPY17_19320	COG0601	transmembrane transport
HPY17_19325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY17_19330	COG4608	Belongs to the ABC transporter superfamily
HPY17_19335	COG1444	tRNA N-acetyltransferase activity
HPY17_19340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY17_19420	COG1192	Involved in chromosome partitioning
HPY17_19875	COG2003	Belongs to the UPF0758 family
HPY17_19930	COG4974	Belongs to the 'phage' integrase family
HPY17_19935	COG2974	May be involved in recombination
HPY17_20030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY17_20370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair