locus-tag	class	description
HPY13_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPY13_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY13_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPY13_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY13_00030	ENOG4108ZNX	Heat shock protein
HPY13_00035	ENOG4105JKW	Valine--pyruvate aminotransferase
HPY13_00040	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HPY13_00045	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HPY13_00060	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HPY13_00070	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HPY13_00075	ENOG4105C7B	Threonine dehydratase
HPY13_00080	ENOG4105C01	Dihydroxy-acid dehydratase
HPY13_00085	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPY13_00100	ENOG4105C0P	Mg chelatase subunit ChlI
HPY13_00105	ENOG4106HNH	Acyl-transferase
HPY13_00110	ENOG4108Z33	Thiol disulfide Interchange Protein
HPY13_00115	ENOG4105E27	serine threonine protein kinase
HPY13_00125	ENOG4105PC1	Conserved Protein
HPY13_00130	ENOG4108N23	SpoOM-related protein
HPY13_00135	ENOG4108UT2	hemolysin iii
HPY13_00145	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY13_00150	ENOG4105C1A	potassium transporter peripheral membrane
HPY13_00155	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HPY13_00160	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HPY13_00170	ENOG4108WZM	domain protein
HPY13_00175	ENOG4105C79	DNA protecting protein DprA
HPY13_00180	ENOG4108RPN	Protein smg homolog
HPY13_00185	ENOG4108WI1	Dna topoisomerase
HPY13_00190	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HPY13_00195	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HPY13_00200	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY13_00205	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HPY13_00210	ENOG4105E2X	shikimate dehydrogenase
HPY13_00220	ENOG4108Z0R	Transferase
HPY13_00255	ENOG4105WMR	Protein CrcB homolog
HPY13_00260	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HPY13_00265	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HPY13_00270	ENOG4105D06	uba thif-type nad fad binding protein
HPY13_00275	ENOG4105WHD	thiamine biosynthesis protein ThiS
HPY13_00280	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPY13_00285	ENOG4105D41	biosynthesis protein thiH
HPY13_00290	ENOG4105DC7	peptidase M24
HPY13_00290	ENOG4105DC7	peptidase M24
HPY13_00295	ENOG4105G2Y	Transcriptional regulator
HPY13_00300	ENOG4105CNH	Multidrug resistance protein MdtL
HPY13_00310	ENOG4108VVK	transcriptional Regulator, AsnC
HPY13_00315	ENOG4105BZU	Histidine kinase
HPY13_00330	ENOG4105EMK	carboxylate amino acid amine transporter
HPY13_00335	ENOG4108M6U	Universal stress protein A
HPY13_00340	ENOG41090A1	ferritin
HPY13_00345	ENOG4108V6B	universal stress protein B
HPY13_00350	ENOG4105CBX	hi0933 family
HPY13_00360	ENOG4105CGY	Dna recombination protein
HPY13_00365	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPY13_00370	ENOG4105JC1	sterol-binding domain protein
HPY13_00380	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY13_00385	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPY13_00390	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPY13_00395	ENOG4105CA0	peroxidase
HPY13_00400	ENOG4107R73	Mate efflux family protein
HPY13_00410	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPY13_00415	ENOG4105E55	glycerol-3-phosphate acyltransferase
HPY13_00420	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HPY13_00425	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HPY13_00430	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY13_00435	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_00445	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HPY13_00450	ENOG4105F8V	Hydrolase, tatD family
HPY13_00455	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPY13_00465	ENOG4105C2M	dna polymerase I
HPY13_00475	ENOG4106RE7	Cytochrome
HPY13_00485	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HPY13_00490	ENOG4105XCT	Protein of unknown function (DUF2489)
HPY13_00495	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY13_00500	ENOG410601J	HemY protein
HPY13_00505	ENOG4105ECF	c-methyltransferase
HPY13_00510	ENOG41076E6	Uroporphyrinogen-III Synthase
HPY13_00515	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPY13_00520	ENOG4107T0K	Adenylate cyclase
HPY13_00525	ENOG4105XQ6	frataxin-like protein
HPY13_00535	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPY13_00540	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPY13_00545	ENOG4105CT0	Protein of unknown function, DUF484
HPY13_00550	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY13_00555	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HPY13_00560	ENOG4105BZU	Histidine kinase
HPY13_00575	ENOG4105DQF	Hydrolase
HPY13_00580	ENOG4108EUD	Lysophospholipase
HPY13_00585	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY13_00590	ENOG4105D58	Diguanylate phosphodiesterase
HPY13_00595	ENOG4108RMU	ferritin dps family protein
HPY13_00625	ENOG4106H78	methyltransferase
HPY13_00630	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPY13_00635	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPY13_00640	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HPY13_00645	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY13_00650	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HPY13_00665	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HPY13_00670	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY13_00675	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HPY13_00680	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPY13_00745	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPY13_00755	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_00760	ENOG4105CUX	Signal transduction histidine kinase
HPY13_00770	ENOG4105C5F	glutamine synthetase
HPY13_00780	ENOG4105CI3	gtp-binding protein typa
HPY13_00790	ENOG4107S2Z	UPF0761 membrane protein
HPY13_00795	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPY13_00800	ENOG4105SUU	thioesterase domain
HPY13_00810	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HPY13_00815	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HPY13_00820	ENOG4105VEJ	Heat shock protein
HPY13_00825	ENOG4108XKW	General secretion pathway protein C
HPY13_00835	ENOG4107QHF	type ii secretion system protein e
HPY13_00840	ENOG4105D7Q	type ii secretion system
HPY13_00845	ENOG4108VAU	general secretion pathway protein G
HPY13_00850	ENOG4105VWV	general secretion pathway protein h
HPY13_00855	ENOG4105X5Z	General secretion pathway protein I
HPY13_00860	ENOG4108WWZ	General secretion pathway protein J
HPY13_00865	ENOG4108RTD	type II secretion system protein K
HPY13_00870	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HPY13_00875	ENOG4105U1E	general secretion pathway protein M
HPY13_00880	ENOG4105PIC	general secretion pathway protein N
HPY13_00885	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HPY13_00890	ENOG4107RK2	ADP-ribose diphosphatase NudE
HPY13_00900	ENOG4105MJ2	Competence protein
HPY13_00910	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY13_00920	ENOG4105BZM	domain protein
HPY13_00925	ENOG4108RRZ	Transcription elongation factor GreB
HPY13_00935	ENOG4105E0F	Histidine kinase
HPY13_00940	ENOG4105C2W	permease
HPY13_00945	ENOG4105CB5	ATP-dependent DNA helicase recG
HPY13_00950	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY13_00955	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HPY13_00960	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPY13_00965	ENOG4105EX9	Membrane
HPY13_00970	ENOG4107QN1	sodium solute
HPY13_00990	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HPY13_01000	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY13_01005	ENOG4108IJ0	Aspartate ammonia-lyase
HPY13_01010	ENOG4105BZU	Histidine kinase
HPY13_01015	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HPY13_01020	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPY13_01030	ENOG4105E0F	Histidine kinase
HPY13_01035	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HPY13_01045	ENOG41076HS	cation diffusion facilitator family transporter
HPY13_01050	ENOG4105CTQ	phosphohexokinase
HPY13_01055	ENOG4105CBT	Fructose-1,6-bisphosphatase
HPY13_01060	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HPY13_01065	ENOG4105SYT	Methylenetetrahydrofolate reductase
HPY13_01070	ENOG4105CFH	Aspartokinase
HPY13_01075	ENOG4105C28	cystathionine
HPY13_01080	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HPY13_01085	ENOG4105C6K	Malic enzyme
HPY13_01090	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPY13_01095	ENOG4105C25	Primosomal protein n'
HPY13_01100	ENOG4105ETE	Transcriptional regulator (LacI family
HPY13_01105	ENOG41063M6	Cell Division Protein
HPY13_01110	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HPY13_01115	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HPY13_01120	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HPY13_01125	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY13_01135	ENOG4105CP7	Triose-phosphate isomerase
HPY13_01160	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY13_01165	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY13_01175	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HPY13_01180	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY13_01190	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HPY13_01195	ENOG4105E33	succinate dehydrogenase
HPY13_01205	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HPY13_01210	ENOG4107YZP	Rhodanese domain protein
HPY13_01215	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HPY13_01220	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPY13_01225	ENOG4105D7W	serine acetyltransferase
HPY13_01235	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HPY13_01240	ENOG4105CWC	Acetylornithine deacetylase
HPY13_01245	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPY13_01250	ENOG4105CAS	nag kinase
HPY13_01255	ENOG4105CDH	Citrulline--aspartate ligase
HPY13_01260	ENOG4105CH7	arginosuccinase
HPY13_01270	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY13_01275	ENOG4105EHV	domain protein
HPY13_01285	ENOG4108JQC	penicillin-binding protein 1A
HPY13_01310	ENOG4105E4G	Type IV pilus
HPY13_01315	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPY13_01320	ENOG4105D49	3-dehydroquinate synthase
HPY13_01330	ENOG4105DFE	Dna adenine methylase
HPY13_01335	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPY13_01340	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY13_01345	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPY13_01360	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HPY13_01365	ENOG4105DDQ	anthranilate synthase
HPY13_01370	ENOG4105C8Y	Acetylornithine aminotransferase
HPY13_01380	ENOG4105C26	Dehydrogenase
HPY13_01390	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HPY13_01395	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HPY13_01405	ENOG4105DNZ	Alpha Beta Hydrolase
HPY13_01415	ENOG4105C5H	ABC transporter
HPY13_01420	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPY13_01435	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HPY13_01440	ENOG4105D44	asparaginase
HPY13_01445	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY13_01450	ENOG4108UV7	flagellar protein motX
HPY13_01455	ENOG4105E68	Sulfatase
HPY13_01460	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY13_01465	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPY13_01470	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPY13_01475	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPY13_01480	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPY13_01485	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPY13_01490	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY13_01495	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPY13_01500	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPY13_01505	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPY13_01510	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HPY13_01515	ENOG41083MP	50s ribosomal protein l29
HPY13_01520	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HPY13_01525	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPY13_01530	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPY13_01535	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY13_01540	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPY13_01545	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HPY13_01550	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HPY13_01555	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HPY13_01560	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPY13_01565	ENOG4105VPB	50S ribosomal protein L30
HPY13_01575	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HPY13_01585	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY13_01590	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPY13_01595	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPY13_01600	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY13_01605	ENOG4108ZT0	50S ribosomal protein l17
HPY13_01615	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY13_01620	ENOG4108UBT	opacity-associated protein
HPY13_01625	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY13_01630	ENOG4107YB6	acetyltransferase, (GNAT) family
HPY13_01635	ENOG4105C1J	atp-dependent rna helicase
HPY13_01645	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HPY13_01650	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPY13_01655	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HPY13_01660	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HPY13_01665	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HPY13_01685	ENOG4105C19	ABC transporter
HPY13_01700	ENOG4108UUE	Transcriptional regulator
HPY13_01705	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPY13_01710	ENOG4105CFU	surface antigen
HPY13_01720	ENOG41066HZ	AIG2-like family
HPY13_01725	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPY13_01735	ENOG4105DFU	Cell wall formation (By similarity)
HPY13_01740	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HPY13_01750	ENOG4106SMU	thiamine transporter membrane protein
HPY13_01755	ENOG4107T0D	ABC, transporter
HPY13_01760	ENOG4105N42	UPF0307 protein
HPY13_01765	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HPY13_01770	ENOG4105CJW	magnesium transporter
HPY13_01775	ENOG41080Z8	PHOSPHOCARRIER protein
HPY13_01780	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPY13_01785	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HPY13_01790	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HPY13_01795	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY13_01800	ENOG4108IUZ	ABC transporter
HPY13_01805	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HPY13_01815	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HPY13_01820	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY13_01830	ENOG4105DHJ	ABC, transporter
HPY13_01835	ENOG4105CY3	ABC transporter, permease
HPY13_01840	ENOG4107PE3	Mammalian cell entry related domain protein
HPY13_01845	ENOG4105E3I	toluene tolerance
HPY13_01855	ENOG4105VFK	BolA family
HPY13_01860	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPY13_01865	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HPY13_01870	ENOG4105KME	endoribonuclease L-psp
HPY13_01880	ENOG4105CXT	aspartate transcarbamylase
HPY13_01890	ENOG4108IAB	Phoh family
HPY13_01900	ENOG4105D3G	Pseudouridine synthase
HPY13_01905	ENOG4105C5I	Dehydrogenase
HPY13_01910	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPY13_01915	ENOG4105MYG	DNA polymerase iii, chi subunit
HPY13_01920	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY13_01925	ENOG4108M8S	permease YjgP YjgQ family protein
HPY13_01930	ENOG4108K5H	permease YjgP YjgQ family protein
HPY13_01945	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY13_01990	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY13_01995	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY13_02000	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPY13_02025	ENOG41064T2	transcriptional regulator, lysR family
HPY13_02030	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY13_02035	ENOG4105C7K	acetolactate synthase
HPY13_02040	ENOG4108ZP8	Acetolactate synthase small subunit
HPY13_02045	ENOG4108RS6	transposase
HPY13_02050	ENOG4108JQ1	Dehydrogenase
HPY13_02055	ENOG4105E66	phosphoriboisomerase A
HPY13_02060	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HPY13_02070	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HPY13_02080	ENOG4105D0A	hydroxylase
HPY13_02085	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY13_02100	ENOG4105Y75	tpr repeat protein
HPY13_02110	ENOG4108IYU	L-aspartate oxidase
HPY13_02115	ENOG4105EMN	RNA polymerase sigma factor
HPY13_02130	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
HPY13_02135	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPY13_02140	ENOG4105C3F	Signal peptidase i
HPY13_02145	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPY13_02150	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPY13_02155	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HPY13_02160	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HPY13_02165	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HPY13_02185	ENOG4105BZU	Histidine kinase
HPY13_02195	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY13_02200	ENOG4105DXN	mazG family
HPY13_02205	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HPY13_02210	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPY13_02230	ENOG4106MWK	domain protein
HPY13_02235	ENOG4105CJ3	phosphate transporter
HPY13_02240	ENOG4107IX6	phosphate transport regulator
HPY13_02245	ENOG4105I7R	Adenylate cyclase
HPY13_02255	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_02260	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPY13_02270	ENOG4105DFG	type I secretion outer membrane protein
HPY13_02275	ENOG41087AY	ADP-Ribose pyrophosphatase
HPY13_02280	ENOG4108SX3	cytoplasmic protein
HPY13_02285	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HPY13_02290	ENOG4105IPS	esterase
HPY13_02295	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY13_02300	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY13_02310	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HPY13_02315	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPY13_02320	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HPY13_02325	ENOG4105D7Q	type ii secretion system
HPY13_02330	ENOG4107QHF	type ii secretion system protein e
HPY13_02335	ENOG4105X0D	Fimbrial protein
HPY13_02340	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HPY13_02350	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY13_02355	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY13_02360	ENOG4105T95	Thiol disulfide interChange protein
HPY13_02365	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HPY13_02370	ENOG41073TP	transcriptional regulator
HPY13_02375	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPY13_02380	ENOG4107QSN	dihydrolipoamide acetyltransferase
HPY13_02385	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY13_02400	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPY13_02405	ENOG4105CJN	penicillin-binding protein
HPY13_02410	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPY13_02415	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HPY13_02425	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPY13_02440	ENOG4105DFU	Cell wall formation (By similarity)
HPY13_02445	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HPY13_02450	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HPY13_02455	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPY13_02460	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY13_02470	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY13_02475	ENOG4105M6F	mutator MutT protein
HPY13_02480	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPY13_02490	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HPY13_02495	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPY13_02515	ENOG4105EJ9	Membrane
HPY13_02520	ENOG4105VP0	transcriptional regulator, lysR family
HPY13_02525	ENOG4105EN6	Membrane
HPY13_02530	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HPY13_02540	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPY13_02550	ENOG4105BZ8	glutamate synthase
HPY13_02555	ENOG4105CBC	glutamate synthase
HPY13_02570	ENOG4105N5T	Radical SAM Protein
HPY13_02580	ENOG4105BZU	Histidine kinase
HPY13_02585	ENOG41065U4	response regulator
HPY13_02595	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY13_02615	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPY13_02620	ENOG4105D98	threonine synthase
HPY13_02625	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HPY13_02630	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HPY13_02635	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPY13_02650	ENOG4105BZG	amino acid carrier protein
HPY13_02655	ENOG4105D1Q	UPF0246 protein
HPY13_02665	ENOG4105EYA	deoxyribonuclease
HPY13_02670	ENOG4105D9N	nucleoside
HPY13_02680	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HPY13_02685	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HPY13_02690	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HPY13_02695	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY13_02705	ENOG4105EAC	phosphoserine phosphatase
HPY13_02715	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPY13_02720	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY13_02725	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY13_02730	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY13_02740	ENOG4105CNT	hydrolase family 2
HPY13_02745	ENOG41060NJ	transcriptional regulator
HPY13_02750	ENOG4108Y51	tRNA-binding protein
HPY13_02765	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY13_02770	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY13_02780	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HPY13_02785	ENOG4105X2V	dna damage-inducible protein
HPY13_02800	ENOG4105DSY	exodeoxyribonuclease V, gamma
HPY13_02805	ENOG4107QKA	exodeoxyribonuclease V beta
HPY13_02810	ENOG4107QYX	exodeoxyribonuclease v alpha
HPY13_02820	ENOG4107QZM	n-acetylglutamate synthase
HPY13_02830	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HPY13_02835	ENOG4105CUZ	uba thif-type nad fad binding protein
HPY13_02840	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HPY13_02845	ENOG4105C9B	Cysteine desulfurase
HPY13_02850	ENOG4107S0N	DJ-1 family
HPY13_02855	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPY13_02870	ENOG4105K6V	RNA polymerase
HPY13_02880	ENOG4105EYM	Major Facilitator superfamily
HPY13_02885	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY13_02895	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY13_02900	ENOG4105M85	Bola protein
HPY13_02905	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY13_02910	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY13_02915	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY13_02920	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY13_02925	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY13_02930	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HPY13_02935	ENOG4105CJ2	(LipO)protein
HPY13_02955	ENOG4105BZU	Histidine kinase
HPY13_02960	ENOG4105C8J	)-transporter
HPY13_02970	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY13_02975	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY13_02980	ENOG4105CIN	aminoacyl-histidine dipeptidase
HPY13_02985	ENOG4105C7N	Xanthine uracil vitamin C permease
HPY13_02990	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HPY13_02995	ENOG4108DJV	Fermentation respiration switch protein
HPY13_03000	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HPY13_03005	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPY13_03010	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPY13_03015	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPY13_03020	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY13_03035	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HPY13_03040	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HPY13_03045	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HPY13_03050	ENOG4108ZAI	phosphatidylglycerophosphatase a
HPY13_03055	ENOG4108T8E	UPF0325 protein
HPY13_03060	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HPY13_03065	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPY13_03070	ENOG4105CE9	30S ribosomal protein S2
HPY13_03075	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HPY13_03080	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPY13_03085	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPY13_03090	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPY13_03095	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPY13_03100	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPY13_03105	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPY13_03115	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HPY13_03120	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY13_03125	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HPY13_03130	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY13_03135	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY13_03140	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY13_03145	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPY13_03150	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HPY13_03155	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HPY13_03160	ENOG4105N7H	Cytochrome
HPY13_03165	ENOG4105PY6	Phenolic acid decarboxylase
HPY13_03170	ENOG4108YZA	Nitrogen regulatory protein pii
HPY13_03175	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HPY13_03180	ENOG4105E9H	Lytic Murein transglycosylase
HPY13_03185	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPY13_03190	ENOG4105D1A	Methyltransferase
HPY13_03195	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY13_03200	ENOG4107RZZ	dna polymerase iii epsilon subunit
HPY13_03210	ENOG4107QPN	acyl-Coa dehydrogenase
HPY13_03215	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY13_03220	ENOG4105E7A	Glutamine amidotransferase
HPY13_03225	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HPY13_03230	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPY13_03235	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HPY13_03240	ENOG4105BZU	Histidine kinase
HPY13_03245	ENOG4105FE9	pseudouridine synthase
HPY13_03250	ENOG4108DG9	Smr protein MutS2
HPY13_03265	ENOG4105MBR	gumn family
HPY13_03270	ENOG4105E2D	ec 3.2.1.52
HPY13_03280	ENOG4105C59	p-type ATPase
HPY13_03285	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPY13_03290	ENOG4105UYK	outer membrane protein a
HPY13_03300	ENOG4107RBR	Receptor
HPY13_03305	ENOG4105Q26	Siderophore-interacting protein
HPY13_03310	ENOG4105C0W	non-ribosomal peptide synthetase
HPY13_03345	ENOG4107R88	Chemotaxis protein (CheV)
HPY13_03350	ENOG4105BZU	Histidine kinase
HPY13_03355	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPY13_03360	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPY13_03365	ENOG4105W00	Flagellar hook capping protein
HPY13_03370	ENOG4105BZE	flagellar hook protein, FlgE
HPY13_03375	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPY13_03380	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPY13_03385	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY13_03390	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY13_03395	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPY13_03410	ENOG4105I03	Flagellin
HPY13_03415	ENOG4105I03	Flagellin
HPY13_03500	ENOG4105C3G	gtp-binding protein
HPY13_03505	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPY13_03510	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPY13_03515	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPY13_03520	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HPY13_03525	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPY13_03530	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPY13_03535	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPY13_03540	ENOG4108YY7	Invasion gene expression up-regulator SirB
HPY13_03545	ENOG41063JG	Transcriptional regulator
HPY13_03550	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY13_03555	ENOG4105CGH	5'-nucleotidase
HPY13_03560	ENOG4108Z66	YbaK ebsC protein
HPY13_03565	ENOG4105C2W	permease
HPY13_03580	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HPY13_03585	ENOG4105K89	arsenate reductase
HPY13_03590	ENOG4105ERG	peptidase m48, ste24p
HPY13_03605	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_03610	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY13_03625	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY13_03645	ENOG4105KUZ	arsenate reductase
HPY13_03660	ENOG4105QZU	Inner membrane protein YfeZ
HPY13_03665	ENOG4105EZR	dyp-type peroxidase family protein
HPY13_03670	ENOG4105I03	Flagellin
HPY13_03675	ENOG4105I03	Flagellin
HPY13_03680	ENOG4105I03	Flagellin
HPY13_03685	ENOG41063QE	flagellar protein FlaG
HPY13_03690	ENOG4107W9T	flagellar hook-associated
HPY13_03700	ENOG4105MQ3	flagellar protein FliS
HPY13_03710	ENOG4105BZU	Histidine kinase
HPY13_03720	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HPY13_03725	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPY13_03730	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY13_03735	ENOG4105W2B	Flagellar assembly protein
HPY13_03740	ENOG4108JIR	Flagellum-specific ATP synthase
HPY13_03760	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY13_03765	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY13_03770	ENOG4105DD5	Flagellar motor switch protein
HPY13_03775	ENOG4105VTB	flagellar biosynthesis protein fliO
HPY13_03780	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPY13_03785	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPY13_03790	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPY13_03795	ENOG4105D00	flagellar biosynthetic protein flhB
HPY13_03800	ENOG4108DG9	Smr protein MutS2
HPY13_03805	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HPY13_03810	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPY13_03815	ENOG4105EN6	Membrane
HPY13_03820	ENOG4108BPE	-transporting atpase
HPY13_03825	ENOG4105MH2	YfcL protein
HPY13_03830	ENOG4105Q8W	reductase
HPY13_03835	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HPY13_03840	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY13_03845	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HPY13_03850	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY13_03855	ENOG41090R7	Ferric uptake
HPY13_03865	ENOG4105CMU	LysR family (Transcriptional regulator
HPY13_03870	ENOG4105VAW	lrga family
HPY13_03875	ENOG41067MG	lrgb family
HPY13_03880	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY13_03890	ENOG4105EV9	Alpha Beta Hydrolase
HPY13_03895	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HPY13_03900	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HPY13_03910	ENOG4107QNR	UPF0135 protein
HPY13_03915	ENOG4105BZN	citrate synthase
HPY13_03920	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HPY13_03925	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HPY13_03930	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HPY13_03935	ENOG4105E33	succinate dehydrogenase
HPY13_03940	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPY13_03945	ENOG4105C7S	Dehydrogenase
HPY13_03950	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HPY13_03955	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HPY13_03960	ENOG4105FAV	ABC, transporter
HPY13_03970	ENOG4105NXV	High-affinity zinc uptake system protein
HPY13_03975	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HPY13_03980	ENOG4105XFK	Ferrous iron transport protein A
HPY13_04000	ENOG4105C75	arginyL-tRNA synthetase
HPY13_04015	ENOG4108BY2	phosphohistidine phosphatase
HPY13_04020	ENOG4105D7B	Flagellar biosynthesis protein flha
HPY13_04025	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HPY13_04035	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY13_04040	ENOG4108VYJ	response regulator receiver protein
HPY13_04045	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HPY13_04055	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY13_04060	ENOG4107QJE	Chromosome Partitioning Protein
HPY13_04070	ENOG4108V3W	Chemotaxis protein, CheW
HPY13_04080	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HPY13_04085	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HPY13_04090	ENOG41060IM	Heme exporter protein
HPY13_04095	ENOG41067VX	Heme exporter protein
HPY13_04100	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HPY13_04105	ENOG4105DA4	cytochrome c-type biogenesis protein
HPY13_04110	ENOG4107QX9	Thiol disulfide interChange protein
HPY13_04115	ENOG4105KWW	Biogenesis protein
HPY13_04125	ENOG410903C	(LipO)protein
HPY13_04140	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY13_04145	ENOG4105M2J	Glutaredoxin
HPY13_04150	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY13_04155	ENOG4105DGU	Histone deacetylase
HPY13_04170	ENOG4105E68	Sulfatase
HPY13_04175	ENOG4105YDX	UPF0352 protein
HPY13_04180	ENOG4106V8H	Nucleoid-associated protein
HPY13_04190	ENOG4105DFD	Na H antiporter
HPY13_04195	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY13_04200	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPY13_04205	ENOG4105C0A	alcohol dehydrogenase
HPY13_04215	ENOG4105CHH	sulfate transporter
HPY13_04220	ENOG4105C03	ribonuclease
HPY13_04225	ENOG4105EI2	Pseudouridine synthase
HPY13_04230	ENOG4108UHJ	MAF-like protein
HPY13_04235	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HPY13_04240	ENOG4105VGS	50s ribosomal protein l32
HPY13_04245	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HPY13_04250	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY13_04255	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HPY13_04260	ENOG4105CHR	reductase
HPY13_04265	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPY13_04270	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY13_04275	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HPY13_04280	ENOG4105HHA	aminodeoxychorismate lyase
HPY13_04285	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPY13_04290	ENOG4107QRG	dna polymerase iii
HPY13_04295	ENOG4105F8V	Hydrolase, tatD family
HPY13_04300	ENOG4105CI1	PTS System
HPY13_04310	ENOG4105C8J	)-transporter
HPY13_04325	ENOG4108NRW	Phospholipase, patatin family
HPY13_04330	ENOG4105CA9	Pyruvate kinase
HPY13_04335	ENOG4105DAG	ROK family
HPY13_04355	ENOG4105DHI	Methyltransferase
HPY13_04365	ENOG4105DSB	aldose 1-epimerase
HPY13_04370	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY13_04375	ENOG4105E0X	reductase
HPY13_04385	ENOG4105VUT	cytoplasmic protein
HPY13_04390	ENOG4105HDK	L-asparaginase
HPY13_04395	ENOG4105D07	Signal peptide peptidase, SppA
HPY13_04400	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY13_04405	ENOG4105CIY	formyltetrahydrofolate deformylase
HPY13_04415	ENOG4105DVT	helicase
HPY13_04420	ENOG41072GX	Peptidase M22 Glycoprotease
HPY13_04435	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY13_04440	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY13_04445	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HPY13_04450	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
HPY13_04460	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY13_04465	ENOG4105DK2	UPF0207 protein
HPY13_04470	ENOG4105CHM	Aminotransferase
HPY13_04475	ENOG4105E4F	Isochorismate synthase
HPY13_04480	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPY13_04485	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HPY13_04490	ENOG4108IPT	Naphthoate synthase
HPY13_04500	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY13_04505	ENOG4105DKK	Benzoate
HPY13_04510	ENOG4107S74	Lysophospholipid transporter LplT
HPY13_04535	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HPY13_04540	ENOG4107QMS	site-determining protein
HPY13_04545	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HPY13_04550	ENOG4105VNG	YcgL domain-containing protein
HPY13_04555	ENOG4105CVE	Lytic murein transglycosylase
HPY13_04560	ENOG4105JQN	Transcriptional regulator
HPY13_04565	ENOG4105D9N	nucleoside
HPY13_04575	ENOG4105CUW	cytochrome C-TYPE protein
HPY13_04580	ENOG4107QY8	reductase
HPY13_04590	ENOG4105JQN	Transcriptional regulator
HPY13_04605	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HPY13_04640	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPY13_04650	ENOG4105BZU	Histidine kinase
HPY13_04660	ENOG4105CNG	UPF0061 protein
HPY13_04665	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPY13_04670	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HPY13_04675	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY13_04680	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_04695	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPY13_04700	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPY13_04705	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPY13_04710	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HPY13_04715	ENOG4105K70	DNA-binding protein
HPY13_04720	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HPY13_04725	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HPY13_04730	ENOG4105CAT	Cytidine monophosphate kinase
HPY13_04735	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPY13_04740	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY13_04745	ENOG4105Q4A	inner membrane protein yciS
HPY13_04750	ENOG4105CFV	Tetratricopeptide repeat protein
HPY13_04765	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPY13_04770	ENOG4107QRA	Extracellular solute-binding protein, family 5
HPY13_04780	ENOG4108JQ7	(ABC) transporter
HPY13_04795	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HPY13_04805	ENOG4107R11	Transcriptional regulator
HPY13_04815	ENOG4105DCF	alanine dehydrogenase
HPY13_04820	ENOG4105EW9	transcriptional regulator AsnC family
HPY13_04825	ENOG4105CNU	cell division protein FtsK
HPY13_04830	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HPY13_04835	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY13_04840	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HPY13_04850	ENOG4108NVR	Methyl-accepting chemotaxis
HPY13_04855	ENOG4105K59	histidine triad (HIT) protein
HPY13_04880	ENOG4105D0Y	UPF0227 protein
HPY13_04885	ENOG4105CEP	NADH dehydrogenase
HPY13_04895	ENOG4106M3D	hemolysin
HPY13_04905	ENOG4108JA2	transcriptioN-repair coupling factor
HPY13_04915	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY13_04920	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY13_04925	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY13_04935	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HPY13_04940	ENOG4105BZ1	(ABC) transporter
HPY13_04945	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HPY13_04950	ENOG4105W49	UPF0434 protein
HPY13_04955	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY13_04960	ENOG4105ED1	spovr family
HPY13_04965	ENOG4106AKX	UPF0229 protein
HPY13_04970	ENOG4105CYN	Serine protein kinase
HPY13_04975	ENOG4105XWI	UPF0304 protein
HPY13_04985	ENOG4105F1A	Pyruvate formate-lyase
HPY13_04990	ENOG4108N3W	hemolysin secretion protein
HPY13_05000	ENOG4105C6N	Formate acetyltransferase
HPY13_05010	ENOG4108JEH	abc transporter atp-binding protein
HPY13_05015	ENOG4105E89	ABC transporter
HPY13_05020	ENOG4105DSP	amino acid AbC transporter
HPY13_05025	ENOG4106YG3	ABC transporter
HPY13_05030	ENOG4105CGK	Exodeoxyribonuclease III
HPY13_05035	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_05040	ENOG4106428	Protein of unknown function (DUF2496)
HPY13_05045	ENOG4108URS	primosomal replication protein n''
HPY13_05050	ENOG4105EJ9	Membrane
HPY13_05055	ENOG4105DVT	helicase
HPY13_05060	ENOG4105ZU8	porin-like protein H
HPY13_05070	ENOG4105K5B	UPF0225 protein
HPY13_05075	ENOG4105D58	Diguanylate phosphodiesterase
HPY13_05080	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HPY13_05085	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY13_05090	ENOG4105C8N	cysteinyl-tRNA synthetase
HPY13_05095	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPY13_05100	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPY13_05110	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY13_05115	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY13_05125	ENOG4105KJB	cyd operon protein YbgE
HPY13_05130	ENOG4107YD3	Thioesterase
HPY13_05135	ENOG4105E02	MotA TolQ exbB proton channel
HPY13_05140	ENOG4105M8F	Biopolymer transport protein exbD tolR
HPY13_05150	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HPY13_05155	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HPY13_05165	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HPY13_05175	ENOG4105BZU	Histidine kinase
HPY13_05180	ENOG4108RNS	Exports L-alanine (By similarity)
HPY13_05185	ENOG4105C26	Dehydrogenase
HPY13_05190	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HPY13_05195	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY13_05205	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY13_05235	ENOG4108478	ec 3.2.1.18
HPY13_05240	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY13_05245	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
HPY13_05255	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
HPY13_05260	ENOG41069H7	transport system small permease component
HPY13_05265	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY13_05275	ENOG4105QEK	Transcriptional regulator
HPY13_05280	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
HPY13_05285	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
HPY13_05295	ENOG4107VGF	ig domain protein group 2 domain protein
HPY13_05320	ENOG4105F2Z	3-oxoadipate enol-lactonase
HPY13_05330	ENOG4105F88	accessory colonization factor AcfD
HPY13_05445	ENOG4105UYK	outer membrane protein a
HPY13_05470	ENOG4108TU9	TRANSCRIPTIONal
HPY13_05480	ENOG41075IY	surface presentation of antigens protein SpaP
HPY13_05560	ENOG4105DFP	Integrase
HPY13_05585	ENOG4105DY2	Paraquat-inducible protein b
HPY13_05590	ENOG4105F1S	paraquat-inducible protein a
HPY13_05615	ENOG4108R86	Transcriptional regulator
HPY13_05620	ENOG4105C26	Dehydrogenase
HPY13_05625	ENOG4105MTM	Protein of unknown function (DUF1496)
HPY13_05640	ENOG41067SE	Tetr family transcriptional regulator
HPY13_05645	ENOG4107QPN	acyl-Coa dehydrogenase
HPY13_05655	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPY13_05660	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HPY13_05665	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HPY13_05675	ENOG4105RKX	Protein of unknown function (DUF2498)
HPY13_05680	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY13_05685	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY13_05690	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPY13_05710	ENOG4105HP8	regulator of competence-specific genes
HPY13_05715	ENOG4105ETE	Transcriptional regulator (LacI family
HPY13_05725	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HPY13_05730	ENOG4107S90	membrAne
HPY13_05735	ENOG4106371	Methyltransferase
HPY13_05740	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HPY13_05745	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HPY13_05750	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
HPY13_05755	ENOG4107QW4	alcohol dehydrogenase
HPY13_05760	ENOG4105CF7	AraC family transcriptional regulator
HPY13_05770	ENOG4105EW9	transcriptional regulator AsnC family
HPY13_05785	ENOG4105CCT	upf0313 protein
HPY13_05810	ENOG4105DZ2	Transcriptional regulator
HPY13_05815	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HPY13_05825	ENOG4105K9H	YciI-like protein
HPY13_05830	ENOG4105NAU	thioesterase Superfamily protein
HPY13_05845	ENOG4105GFG	DUF218 domain
HPY13_05850	ENOG4107SRH	Nad-dependent epimerase dehydratase
HPY13_05860	ENOG4105TMB	Formate nitrite transporter
HPY13_05875	ENOG4107QY8	reductase
HPY13_05890	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HPY13_05905	ENOG4108JQ2	peptide transport system atp-binding protein
HPY13_05910	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HPY13_05915	ENOG4108EU3	peptide transport system, permease
HPY13_05920	ENOG4108I5W	peptide transport system, permease protein
HPY13_05925	ENOG4108J59	Extracellular solute-binding protein, family 5
HPY13_05930	ENOG4105E51	psp operon transcriptional activator
HPY13_05935	ENOG41087YS	Phage shock protein A
HPY13_05950	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPY13_05965	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HPY13_05970	ENOG4105C28	cystathionine
HPY13_05980	ENOG4105C8J	)-transporter
HPY13_05985	ENOG4108W1A	pseudouridine synthase
HPY13_05990	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HPY13_05995	ENOG4108VGW	abc transporter atp-binding protein
HPY13_06000	ENOG4105CXZ	ABC transporter, permease
HPY13_06005	ENOG4105VNH	ABC transporter solute-binding protein
HPY13_06015	ENOG4105XZD	Fe-S protein
HPY13_06025	ENOG4107QWP	ABC-2 type transporter
HPY13_06030	ENOG4105CJ1	ABC, transporter
HPY13_06040	ENOG4105C44	Serine transporter
HPY13_06050	ENOG4105CJW	magnesium transporter
HPY13_06060	ENOG4105BZU	Histidine kinase
HPY13_06070	ENOG4105KXC	Collagenase
HPY13_06100	ENOG4108N3W	hemolysin secretion protein
HPY13_06115	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPY13_06120	ENOG4105BZU	Histidine kinase
HPY13_06135	ENOG4105CFI	type iii restriction protein res subunit
HPY13_06140	ENOG4105I08	Pseudouridine synthase
HPY13_06145	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY13_06155	ENOG4105CGD	Nad-dependent epimerase dehydratase
HPY13_06160	ENOG4105UQX	Mate efflux family protein
HPY13_06165	ENOG4108I0Y	(ABC) transporter
HPY13_06180	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY13_06190	ENOG4105E3Q	saccharopine dehydrogenase
HPY13_06195	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HPY13_06200	ENOG4105CDV	Ompa motb domain protein
HPY13_06205	ENOG4105DFG	type I secretion outer membrane protein
HPY13_06225	ENOG4105F04	LysR family Transcriptional regulator
HPY13_06235	ENOG4108VKG	metal-dependent hydrolase
HPY13_06250	ENOG41090FY	type IV pilus biogenesis stability protein PilW
HPY13_06255	ENOG4105CVG	Homoserine O-transsuccinylase
HPY13_06275	ENOG4107V40	secretion protein, HlyD family
HPY13_06290	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY13_06295	ENOG4106YYS	transcriptional regulatory protein
HPY13_06305	ENOG4107R88	Chemotaxis protein (CheV)
HPY13_06350	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPY13_06355	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPY13_06360	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPY13_06365	ENOG4106TD9	Diguanylate cyclase
HPY13_06370	ENOG4105BZU	Histidine kinase
HPY13_06380	ENOG4105C7K	acetolactate synthase
HPY13_06385	ENOG4107FQX	Alpha-acetolactate decarboxylase
HPY13_06400	ENOG4108TWJ	NADH dehydrogenase subunit 5
HPY13_06405	ENOG4105DUM	transcriptional regulator, lysR family
HPY13_06410	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
HPY13_06425	ENOG4105V0I	UPF0267 protein
HPY13_06440	ENOG4105C9Q	fumarate hydratase class II
HPY13_06450	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY13_06455	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY13_06460	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY13_06465	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY13_06470	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY13_06480	ENOG4107QZV	Type I secretion membrane fusion protein
HPY13_06495	ENOG4105CS2	ec 3.2.1.21
HPY13_06500	ENOG4105DDV	Transcriptional regulator (LacI family
HPY13_06505	ENOG4105M4H	endoribonuclease L-psp
HPY13_06510	ENOG4105XEP	YhcH YjgK YiaL family protein
HPY13_06515	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HPY13_06520	ENOG4105E98	transcriptional regulator DeoR family
HPY13_06525	ENOG4108IJ9	(ABC) transporter
HPY13_06530	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HPY13_06535	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HPY13_06560	ENOG4109015	Biopolymer transport protein exbD tolR
HPY13_06565	ENOG41067XB	TonB family
HPY13_06585	ENOG4107QI1	Mate efflux family protein
HPY13_06605	ENOG4107TT5	NLP P60 protein
HPY13_06610	ENOG4108N3W	hemolysin secretion protein
HPY13_06620	ENOG4106IUH	DTW domain containing protein
HPY13_06625	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HPY13_06635	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY13_06640	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HPY13_06645	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY13_06650	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HPY13_06660	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_06665	ENOG4105BZU	Histidine kinase
HPY13_06670	ENOG4105C5H	ABC transporter
HPY13_06675	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPY13_06695	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY13_06705	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY13_06710	ENOG4105QAX	Iron-sulfur
HPY13_06725	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HPY13_06730	ENOG4108VPT	UPF0234 protein
HPY13_06735	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY13_06750	ENOG4105QNR	S1 RNA binding domain protein
HPY13_06760	ENOG4105DY2	Paraquat-inducible protein b
HPY13_06765	ENOG4105H2K	paraquat-inducible protein a
HPY13_06770	ENOG4105BZ1	(ABC) transporter
HPY13_06775	ENOG4108ZGC	gaf domain protein
HPY13_06780	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HPY13_06785	ENOG4105CN1	protease
HPY13_06795	ENOG4105CD8	aminopeptidase N
HPY13_06805	ENOG4105C7I	Dehydrogenase
HPY13_06810	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPY13_06815	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HPY13_06820	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HPY13_06830	ENOG4105C5H	ABC transporter
HPY13_06845	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HPY13_06850	ENOG4105DAN	ATP-dependent protease
HPY13_06855	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
HPY13_06935	ENOG4105EUK	rtx toxin RtxA
HPY13_06940	ENOG4108RC6	RTX toxin
HPY13_06965	ENOG4105BZU	Histidine kinase
HPY13_06980	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HPY13_06995	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HPY13_07005	ENOG4105C59	p-type ATPase
HPY13_07020	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HPY13_07025	ENOG4105Q9Y	Universal stress protein
HPY13_07030	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HPY13_07050	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY13_07060	ENOG4105D38	putrescine abc transporter
HPY13_07065	ENOG4108HM4	ABC transporter
HPY13_07070	ENOG4107RUE	extracellular solute-binding protein family 1
HPY13_07085	ENOG4105BZG	amino acid carrier protein
HPY13_07090	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY13_07135	ENOG4105CS6	Rhs element vgr protein
HPY13_07140	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY13_07145	ENOG4105CTD	carboxy-peptidase
HPY13_07150	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_07155	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY13_07160	ENOG4105CW7	secretion protein, HlyD family
HPY13_07165	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HPY13_07175	ENOG4105C1J	atp-dependent rna helicase
HPY13_07180	ENOG4107SDU	Methyl-accepting chemotaxis
HPY13_07185	ENOG4108N3W	hemolysin secretion protein
HPY13_07190	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_07195	ENOG4108V3W	Chemotaxis protein, CheW
HPY13_07200	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY13_07210	ENOG4105BZU	Histidine kinase
HPY13_07220	ENOG4105CBS	Chea signal transduction histidine kinase
HPY13_07235	ENOG4108NVR	Methyl-accepting chemotaxis
HPY13_07240	ENOG4105KPY	Small multidrug resistance protein
HPY13_07245	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY13_07250	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY13_07255	ENOG4105EJC	lysr family transcriptional regulator
HPY13_07265	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HPY13_07270	ENOG4105R8A	Heat shock protein
HPY13_07280	ENOG4105CQ7	ATP-dependent helicase
HPY13_07300	ENOG4105BZU	Histidine kinase
HPY13_07310	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY13_07315	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY13_07320	ENOG4105BZU	Histidine kinase
HPY13_07330	ENOG4105BZU	Histidine kinase
HPY13_07350	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HPY13_07355	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HPY13_07360	ENOG410667J	hydrolase
HPY13_07370	ENOG4107QXX	ABC transporter
HPY13_07375	ENOG4105EZ7	amino acid ABC transporter
HPY13_07380	ENOG4105DRP	amino acid AbC transporter
HPY13_07385	ENOG4105CDA	abc transporter atp-binding protein
HPY13_07390	ENOG4108MN8	Membrane
HPY13_07395	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HPY13_07400	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HPY13_07410	ENOG4106TD9	Diguanylate cyclase
HPY13_07420	ENOG4105BZU	Histidine kinase
HPY13_07425	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY13_07430	ENOG4108RXX	maleylacetoacetate isomerase
HPY13_07440	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HPY13_07445	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPY13_07450	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY13_07465	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY13_07470	ENOG4105C7F	AcnD-accessory protein PrpF
HPY13_07475	ENOG4108I0Z	Aconitate hydratase
HPY13_07480	ENOG4105BZN	citrate synthase
HPY13_07485	ENOG4105CR4	methylisocitrate lyase
HPY13_07510	ENOG4108PTX	LysR family Transcriptional regulator
HPY13_07515	ENOG4105D05	Receptor
HPY13_07540	ENOG4105EFX	secretion protein, HlyD family
HPY13_07555	ENOG4107SDZ	Galactoside transport system permease protein mglC
HPY13_07560	ENOG4105C2J	ABC transporter
HPY13_07585	ENOG4107EXC	regulatoR
HPY13_07590	ENOG4105EB3	Histidine kinase
HPY13_07595	ENOG4105RW8	MltA-interacting MipA family protein
HPY13_07600	ENOG4108MJ5	VirK protein
HPY13_07605	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_07610	ENOG4105BZU	Histidine kinase
HPY13_07615	ENOG4105C8P	)-transporter
HPY13_07620	ENOG4108NVR	Methyl-accepting chemotaxis
HPY13_07625	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY13_07640	ENOG4105D9U	N-acetyltransferase
HPY13_07645	ENOG4108JU8	Transcriptional regulator
HPY13_07655	ENOG4105CM6	amino acid regulated cytosolic protein
HPY13_07670	ENOG4105CRQ	synthase (Component I)
HPY13_07675	ENOG4105P8F	nudix hydrolase
HPY13_07680	ENOG4105C44	Serine transporter
HPY13_07685	ENOG4105EJQ	L-serine dehydratase
HPY13_07690	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HPY13_07700	ENOG4108N3W	hemolysin secretion protein
HPY13_07705	ENOG4105C5S	asparaginyl-tRNA synthetase
HPY13_07715	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY13_07720	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY13_07735	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_07740	ENOG4105DJ9	glucan biosynthesis protein
HPY13_07745	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HPY13_07750	ENOG41060NJ	transcriptional regulator
HPY13_07755	ENOG410901P	UPF0249 protein
HPY13_07760	ENOG4105F8D	glycoside hydrolase family 4
HPY13_07765	ENOG4105VCP	PTS System
HPY13_07775	ENOG4105VZJ	PTS System
HPY13_07785	ENOG4105C94	Transporter
HPY13_07790	ENOG41067TZ	transcriptional regulator, MarR family
HPY13_07805	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY13_07815	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY13_07830	ENOG4105C5X	domain protein
HPY13_07835	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HPY13_07865	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HPY13_07875	ENOG4105S8Q	sugar efflux transporter
HPY13_07885	ENOG4105C72	UPF0176 protein
HPY13_07890	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY13_07895	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPY13_07900	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY13_07905	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY13_07910	ENOG4107QK7	reductase
HPY13_07935	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_07950	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HPY13_07955	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HPY13_07970	ENOG4108YZT	Adenosylcobinamide kinase
HPY13_07975	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HPY13_07980	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HPY13_07985	ENOG4105E0X	reductase
HPY13_07990	ENOG4108ETY	sodium dicarboxylate symporter
HPY13_08005	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPY13_08010	ENOG4105KT5	UmuD protein
HPY13_08150	ENOG4105KUS	lysozyme
HPY13_08220	ENOG4106V8H	Nucleoid-associated protein
HPY13_08245	ENOG4105DFP	Integrase
HPY13_08250	ENOG4105CJB	Exodeoxyribonuclease I
HPY13_08255	ENOG4105VAW	lrga family
HPY13_08260	ENOG41067MG	lrgb family
HPY13_08290	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY13_08295	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HPY13_08300	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPY13_08340	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPY13_08345	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY13_08350	ENOG4105CQ2	DNA polymerase
HPY13_08355	ENOG4105BZU	Histidine kinase
HPY13_08365	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY13_08370	ENOG4108W5H	UPF0263 protein
HPY13_08380	ENOG4105CZE	histidine utilization repressor
HPY13_08385	ENOG4105CI2	imidazolone-5-propionate hydrolase
HPY13_08390	ENOG41088SP	formiminoglutamate hydrolase
HPY13_08395	ENOG4105CGP	Urocanate hydratase
HPY13_08400	ENOG4105C84	Histidine ammonia-lyase
HPY13_08410	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
HPY13_08420	ENOG4105CQB	FAD linked oxidase domain protein
HPY13_08435	ENOG4108ZG0	Ompa motb domain protein
HPY13_08455	ENOG4105C8V	SAICAR synthetase
HPY13_08465	ENOG4107R1I	NAD-dependent malic enzyme
HPY13_08475	ENOG4107GZ4	SanA protein
HPY13_08480	ENOG4105BZU	Histidine kinase
HPY13_08485	ENOG4105C9B	Cysteine desulfurase
HPY13_08495	ENOG4105C3M	thioredoxin reductase
HPY13_08500	ENOG4108JJ9	ABC, transporter
HPY13_08505	ENOG4108JJ8	(ABC) transporter
HPY13_08510	ENOG4105FE9	pseudouridine synthase
HPY13_08515	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPY13_08520	ENOG4105DB7	PHP domain protein
HPY13_08530	ENOG4105CRQ	synthase (Component I)
HPY13_08535	ENOG4105DDQ	anthranilate synthase
HPY13_08540	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPY13_08545	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPY13_08550	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPY13_08555	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPY13_08560	ENOG4105CK2	sodium dicarboxylate symporter
HPY13_08565	ENOG4107104	thymidine kinase
HPY13_08570	ENOG4105C9M	aspartyl-trna synthetase
HPY13_08575	ENOG41081XQ	Conserved Protein
HPY13_08580	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HPY13_08585	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HPY13_08590	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY13_08605	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPY13_08615	ENOG4105CUX	Signal transduction histidine kinase
HPY13_08640	ENOG4105DWU	Membrane
HPY13_08650	ENOG4105DY8	decarboxylase
HPY13_08655	ENOG4106KNT	transcriptional regulator
HPY13_08660	ENOG4105C0A	alcohol dehydrogenase
HPY13_08665	ENOG41090BQ	Glutaredoxin
HPY13_08670	ENOG4105D0C	transport protein
HPY13_08675	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY13_08680	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPY13_08685	ENOG4105VEQ	Cold shock protein
HPY13_08695	ENOG4108R99	pseudouridine synthase
HPY13_08700	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HPY13_08705	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPY13_08710	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY13_08715	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HPY13_08720	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPY13_08725	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPY13_08730	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPY13_08735	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPY13_08740	ENOG4107S6Z	Na H antiporter
HPY13_08750	ENOG4107RE1	Inosine-guanosine kinase
HPY13_08755	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPY13_08760	ENOG41075W9	High frequency lysogenization protein HflD homolog
HPY13_08765	ENOG4107QTF	adenylosuccinate lyase
HPY13_08775	ENOG4105RHG	
HPY13_08785	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HPY13_08800	ENOG4107FW0	short-chain dehydrogenase reductase
HPY13_08810	ENOG4105D0M	Protease HtpX homolog
HPY13_08820	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HPY13_08825	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HPY13_08830	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY13_08835	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HPY13_08840	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HPY13_08845	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPY13_08850	ENOG4105D1H	recombination factor protein RarA
HPY13_08860	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY13_08865	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HPY13_08870	ENOG4105BZU	Histidine kinase
HPY13_08875	ENOG4108JJB	ABC transporter
HPY13_08880	ENOG4105C7J	ABC transporter, permease
HPY13_08890	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY13_08895	ENOG4105PQ6	UPF0208 membrane protein
HPY13_08900	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY13_08905	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HPY13_08910	ENOG4105CHF	Glutathione S-transferase
HPY13_08915	ENOG4108JQ7	(ABC) transporter
HPY13_08920	ENOG4105C3U	ABC transporter
HPY13_08925	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY13_08930	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY13_08935	ENOG4107QSI	ABC, transporter
HPY13_08950	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_08955	ENOG4105BZU	Histidine kinase
HPY13_08960	ENOG4105BZU	Histidine kinase
HPY13_08965	ENOG4105BZU	Histidine kinase
HPY13_08975	ENOG4107YTP	response regulator receiver protein
HPY13_08990	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY13_09005	ENOG4108V1U	phospholipid-binding protein
HPY13_09020	ENOG4105D2N	Aldolase
HPY13_09025	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY13_09030	ENOG4108YTN	IIa component
HPY13_09035	ENOG4105F3R	pts system mannose fructose sorbose family iid
HPY13_09045	ENOG4108RG5	PTS system N-acetylgalactosamine-specific transporter subunit IIB
HPY13_09050	ENOG4105E70	isomerase
HPY13_09055	ENOG4105C6Q	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HPY13_09060	ENOG410804X	Transcriptional regulator
HPY13_09065	ENOG4105E98	transcriptional regulator DeoR family
HPY13_09080	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY13_09085	ENOG41082YX	Transcriptional regulator, arsr family
HPY13_09095	ENOG4105BZU	Histidine kinase
HPY13_09115	ENOG4105C29	acyl-CoA thioesterase
HPY13_09120	ENOG4108XM1	transcriptional regulator AsnC family
HPY13_09130	ENOG4105ERU	peptidase
HPY13_09135	ENOG4105UBK	short-chain dehydrogenase reductase
HPY13_09140	ENOG4108ZZ3	UPF0260 protein
HPY13_09145	ENOG4105KRS	Proteinase inhibitor
HPY13_09150	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HPY13_09155	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HPY13_09160	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HPY13_09165	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPY13_09170	ENOG4105WD1	Membrane
HPY13_09175	ENOG4105I93	response regulator
HPY13_09180	ENOG4105EJC	lysr family transcriptional regulator
HPY13_09185	ENOG41069NU	Nitroreductase
HPY13_09190	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY13_09195	ENOG4105CHU	acetyl-coa acetyltransferase
HPY13_09210	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY13_09215	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY13_09225	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HPY13_09230	ENOG4108GAE	asmA family
HPY13_09235	ENOG4105DBI	uridine monophosphokinase
HPY13_09240	ENOG4105D1F	ATP-binding protein
HPY13_09245	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPY13_09260	ENOG4108I5U	Uridine phosphorylase
HPY13_09275	ENOG4105BZU	Histidine kinase
HPY13_09280	ENOG4108ZAF	Molybdopterin
HPY13_09285	ENOG4105M00	molybdopterin converting factor, subunit 1
HPY13_09290	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY13_09295	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HPY13_09300	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY13_09305	ENOG4105CHW	UPF0052 protein
HPY13_09315	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_09320	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HPY13_09335	ENOG4108R3D	Electron transport complex
HPY13_09355	ENOG4105DZB	Electron transport complex
HPY13_09360	ENOG4105CSM	endonuclease III
HPY13_09365	ENOG4108UYE	Lactoylglutathione lyase
HPY13_09370	ENOG4106WH9	Protein of unknown function (DUF2753)
HPY13_09375	ENOG4105EIY	sodium-type flagellar protein motY
HPY13_09380	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HPY13_09385	ENOG4105D3Y	Na H antiporter
HPY13_09390	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HPY13_09395	ENOG4105E96	Colicin v production protein
HPY13_09400	ENOG4108S3P	Sporulation domain protein
HPY13_09405	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPY13_09410	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HPY13_09415	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPY13_09430	ENOG4105CI1	PTS System
HPY13_09435	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY13_09440	ENOG4105E2R	ROK family
HPY13_09445	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPY13_09450	ENOG4105CAQ	asparagine synthetase
HPY13_09455	ENOG4105MDZ	Transcriptional activator rfaH
HPY13_09460	ENOG4105DUX	Transporter
HPY13_09465	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPY13_09470	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPY13_09475	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HPY13_09480	ENOG4108TU9	TRANSCRIPTIONal
HPY13_09495	ENOG4108RE9	Phosphodiesterase
HPY13_09500	ENOG4105ECP	epimerase
HPY13_09505	ENOG4105E1F	short-chain dehydrogenase reductase
HPY13_09510	ENOG4107QR8	Thioredoxin
HPY13_09515	ENOG4107QX8	SPFH domain, Band 7 family protein
HPY13_09520	ENOG4105G5H	Membrane
HPY13_09525	ENOG4108Z6Z	Transcriptional regulator
HPY13_09535	ENOG41081QG	Porin Gram-negative type
HPY13_09540	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPY13_09545	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HPY13_09550	ENOG4105EXN	Sulfate transport protein CysZ
HPY13_09555	ENOG4105C6T	cysteine synthase
HPY13_09560	ENOG4105KZ7	phosphocarrier protein hpr
HPY13_09565	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPY13_09570	ENOG4105C5Y	PTS System
HPY13_09575	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY13_09580	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HPY13_09585	ENOG4105C9A	Phoh family
HPY13_09590	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HPY13_09595	ENOG4108JU5	Magnesium and cobalt efflux protein
HPY13_09600	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HPY13_09610	ENOG4105C8T	Leucyl-tRNA synthetase
HPY13_09615	ENOG4108U2H	Rare lipoprotein B
HPY13_09620	ENOG4105DJF	DNA polymerase III, delta' subunit
HPY13_09625	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HPY13_09630	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HPY13_09635	ENOG4105CJN	penicillin-binding protein
HPY13_09640	ENOG4105CNI	cell division protein FtsW
HPY13_09645	ENOG4105K6T	rare lipoprotein A
HPY13_09650	ENOG4105DZ1	carboxypeptidase
HPY13_09655	ENOG4108Z43	UPF0250 protein
HPY13_09660	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HPY13_09665	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPY13_09675	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY13_09695	ENOG4105D75	Capsular exopolysaccharide family
HPY13_09700	ENOG4105DAY	polysaccharide export protein
HPY13_09710	ENOG4105D3Q	Sugar transferase
HPY13_09725	ENOG4108MA4	Peptidase M66
HPY13_09740	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HPY13_09750	ENOG4105Q84	sucrose synthase
HPY13_09760	ENOG4107XU6	Glycosyl transferase (Group 1
HPY13_09795	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY13_09800	ENOG4105KJF	protein tyrosine phosphatase
HPY13_09805	ENOG4105BZS	acriflavin resistance protein
HPY13_09835	ENOG4105CG3	alpha amylase, catalytic region
HPY13_09840	ENOG4105C5Y	PTS System
HPY13_09845	ENOG4105D4X	repressor
HPY13_09850	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HPY13_09855	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HPY13_09860	ENOG4108UMI	ABC transporter, permease
HPY13_09865	ENOG4105D01	(LipO)protein
HPY13_09870	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HPY13_09875	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HPY13_09880	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HPY13_09890	ENOG4105BZU	Histidine kinase
HPY13_09895	ENOG4105EWT	decarboxylase family
HPY13_09900	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HPY13_09905	ENOG4105M08	Membrane
HPY13_09910	ENOG4105ETT	transcriptional Regulator, LysR family
HPY13_09915	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HPY13_09920	ENOG4106VK6	Flagellar motor protein
HPY13_09925	ENOG4105E14	MotA TolQ exbB proton channel
HPY13_09935	ENOG4105CTB	Polyprenyl synthetase
HPY13_09940	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HPY13_09945	ENOG4105DR9	pseudouridine synthase
HPY13_09950	ENOG4105WP7	tRNA pseudouridine synthase C
HPY13_09965	ENOG4108428	Inherit from COG: -acetyltransferase
HPY13_09975	ENOG4108UPT	UPF0178 protein
HPY13_09980	ENOG4105CFC	Transporter
HPY13_09990	ENOG4105NRA	50s ribosomal protein l31 type b
HPY13_09995	ENOG4108R96	Methyltransferase, YaeB family
HPY13_10000	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPY13_10020	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPY13_10030	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPY13_10035	ENOG4108Z6B	deaminase
HPY13_10040	ENOG4105CFC	Transporter
HPY13_10070	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY13_10075	ENOG4105CFG	Acts as a chaperone (By similarity)
HPY13_10080	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY13_10085	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPY13_10090	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPY13_10095	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY13_10100	ENOG4105VDB	UPF0125 protein
HPY13_10105	ENOG4108Z1B	Cyclase dehydrase
HPY13_10110	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPY13_10160	ENOG4105DZ0	fad dependent oxidoreductase
HPY13_10165	ENOG4108Z4U	Ferredoxin
HPY13_10190	ENOG4105CHY	citrate lyase, alpha
HPY13_10195	ENOG4105CI0	Citrate lyase
HPY13_10200	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
HPY13_10205	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
HPY13_10210	ENOG4105D2K	citrate carrier protein
HPY13_10220	ENOG4107QSA	Oxaloacetate decarboxylase
HPY13_10225	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY13_10230	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY13_10235	ENOG4106YYS	transcriptional regulatory protein
HPY13_10250	ENOG4105F04	LysR family Transcriptional regulator
HPY13_10260	ENOG4105BZG	amino acid carrier protein
HPY13_10265	ENOG4108TSE	Transferase
HPY13_10270	ENOG4105E0A	ABC, transporter
HPY13_10275	ENOG4105TVJ	transport system, permease
HPY13_10280	ENOG4105DQ5	transport system permease protein
HPY13_10285	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HPY13_10295	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HPY13_10300	ENOG4105E4F	Isochorismate synthase
HPY13_10305	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY13_10310	ENOG4105WQI	isochorismatase
HPY13_10315	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HPY13_10325	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPY13_10330	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY13_10335	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPY13_10350	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPY13_10355	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY13_10360	ENOG4105N21	Membrane
HPY13_10365	ENOG4105CUT	histidyl-tRNA synthetase
HPY13_10370	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPY13_10385	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HPY13_10390	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY13_10395	ENOG4105WVQ	Fe-S assembly protein IscX
HPY13_10400	ENOG4108ZIT	Ferredoxin, 2FE-2S
HPY13_10415	ENOG4108Z4V	iron-sulfur cluster assembly
HPY13_10420	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HPY13_10430	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HPY13_10435	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HPY13_10440	ENOG4105ECY	inositol monophosphatase
HPY13_10445	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY13_10450	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY13_10455	ENOG4105VIE	preprotein translocase, subunit YajC
HPY13_10465	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HPY13_10470	ENOG4105W87	Cbs domain
HPY13_10475	ENOG4108I9X	Isocitrate lyase
HPY13_10480	ENOG4107QP3	malate synthase g
HPY13_10485	ENOG4105C5Q	Transcriptional regulator
HPY13_10490	ENOG4105D3R	alkyl hydroperoxide reductase
HPY13_10495	ENOG4106N3A	copper homeostasis protein cutc
HPY13_10500	ENOG4105CSR	polyphosphate kinase 2
HPY13_10510	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY13_10515	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY13_10520	ENOG4105C8U	phosphate abc transporter
HPY13_10525	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HPY13_10530	ENOG4105C9X	ppx gppa phosphatase
HPY13_10535	ENOG4105DJH	phosphate
HPY13_10540	ENOG4105BZU	Histidine kinase
HPY13_10545	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY13_10555	ENOG4105CFP	Peptidase U32
HPY13_10560	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HPY13_10605	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY13_10610	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPY13_10615	ENOG4105C34	Pseudouridine synthase
HPY13_10620	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY13_10625	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HPY13_10635	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
HPY13_10640	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY13_10650	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
HPY13_10655	ENOG4107SC1	transglycosylase
HPY13_10660	ENOG4105C5H	ABC transporter
HPY13_10675	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY13_10680	ENOG4108HRK	Histidine kinase
HPY13_10685	ENOG4108NEV	two component transcriptional regulator, LytTR family
HPY13_10695	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HPY13_10700	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY13_10720	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPY13_10725	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HPY13_10730	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HPY13_10740	ENOG4105DTN	riboflavin biosynthesis protein ribF
HPY13_10745	ENOG4105CJR	Integral membrane protein (MviN
HPY13_10750	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HPY13_10755	ENOG41080HT	Transcriptional regulator, arsr family
HPY13_10760	ENOG41063Z6	transcriptional regulator, lysR family
HPY13_10775	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPY13_10780	ENOG4105HF0	Membrane
HPY13_10785	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HPY13_10790	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPY13_10795	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
HPY13_10800	ENOG4105CPC	Aldo Keto reductase
HPY13_10810	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_10815	ENOG4105CRK	lysyL-tRNA synthetase
HPY13_10825	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPY13_10835	ENOG4105C1J	atp-dependent rna helicase
HPY13_10845	ENOG4105BZU	Histidine kinase
HPY13_10860	ENOG4108YYD	acetyltransferase
HPY13_10870	ENOG4105BZU	Histidine kinase
HPY13_10900	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HPY13_10905	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HPY13_10915	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HPY13_10920	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPY13_10925	ENOG4105CHV	Transcription elongation factor NusA
HPY13_10930	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HPY13_10945	ENOG4105NTZ	Preprotein translocase subunit SecG
HPY13_10955	ENOG4105EEI	dihydropteroate synthase
HPY13_10960	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPY13_10965	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HPY13_10970	ENOG4105HBR	Rna-binding protein
HPY13_10975	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPY13_10980	ENOG4107QE9	Inherit from COG: Membrane
HPY13_10985	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HPY13_10990	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY13_10995	ENOG4105DR5	peptidase
HPY13_11010	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HPY13_11015	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPY13_11020	ENOG4105IPI	Membrane
HPY13_11025	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY13_11035	ENOG4107QRA	Extracellular solute-binding protein, family 5
HPY13_11045	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY13_11055	ENOG4108JQ7	(ABC) transporter
HPY13_11065	ENOG4105RD7	BadF BadG BcrA BcrD
HPY13_11070	ENOG4105E2D	ec 3.2.1.52
HPY13_11075	ENOG4105E2V	Glycosyltransferase 36
HPY13_11085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY13_11110	ENOG4105XTV	UPF0231 protein
HPY13_11115	ENOG4107QIJ	Aconitate hydratase 2
HPY13_11120	ENOG4105D78	K07001 NTE family protein
HPY13_11125	ENOG4105BZ4	penicillin-binding protein
HPY13_11130	ENOG4105CQ7	ATP-dependent helicase
HPY13_11140	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HPY13_11145	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPY13_11150	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HPY13_11155	ENOG4105DJ0	Poly(A) Polymerase
HPY13_11160	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY13_11165	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPY13_11170	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPY13_11175	ENOG4105E3A	(ABC) transporter
HPY13_11180	ENOG4105DA5	(ABC) transporter
HPY13_11185	ENOG4105CHH	sulfate transporter
HPY13_11190	ENOG41077A9	carbonic anhydrase
HPY13_11195	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPY13_11200	ENOG410630P	Transcriptional regulator
HPY13_11205	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HPY13_11210	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HPY13_11215	ENOG41082RQ	UPF0102 protein
HPY13_11220	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY13_11225	ENOG4105W4M	Transport-associated protein
HPY13_11230	ENOG4105KB2	stringent starvation protein b
HPY13_11235	ENOG4107MKT	Stringent starvation protein a
HPY13_11240	ENOG4105EIX	cytochrome c1
HPY13_11245	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY13_11250	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY13_11255	ENOG4108UJD	30S ribosomal protein S9
HPY13_11260	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPY13_11265	ENOG4105D6Z	AFG1 family ATPase
HPY13_11275	ENOG4105C0H	protease
HPY13_11280	ENOG4105C0H	protease
HPY13_11285	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HPY13_11290	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPY13_11295	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPY13_11300	ENOG4105K5M	30s ribosomal protein S16
HPY13_11305	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY13_11310	ENOG4106KVJ	cytochrome C assembly protein
HPY13_11315	ENOG4108JU6	CBS domain protein
HPY13_11320	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPY13_11325	ENOG4105D9M	gamma-glutamylcysteine synthetase
HPY13_11335	ENOG4105W39	Membrane
HPY13_11345	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY13_11350	ENOG4107QSA	Oxaloacetate decarboxylase
HPY13_11400	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HPY13_11405	ENOG4105CFH	Aspartokinase
HPY13_11410	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPY13_11415	ENOG4105Y3E	Modulates RecA activity (By similarity)
HPY13_11420	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPY13_11430	ENOG4108IJ6	ABC transporter
HPY13_11435	ENOG4105ECW	sulfate abc transporter
HPY13_11440	ENOG4108I5D	sulfate abc transporter
HPY13_11445	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY13_11450	ENOG4105C6T	cysteine synthase
HPY13_11455	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HPY13_11460	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY13_11465	ENOG4108K5P	(LipO)protein
HPY13_11470	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HPY13_11475	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HPY13_11480	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HPY13_11485	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPY13_11490	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPY13_11500	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPY13_11505	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY13_11510	ENOG4107ZVW	dihydroneopterin aldolase
HPY13_11515	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HPY13_11525	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY13_11530	ENOG4105VCC	30S ribosomal protein S21
HPY13_11535	ENOG4105KTH	gatB Yqey
HPY13_11540	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPY13_11545	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY13_11560	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY13_11565	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HPY13_11570	ENOG410804X	Transcriptional regulator
HPY13_11575	ENOG4105CA9	Pyruvate kinase
HPY13_11580	ENOG4105MPN	Membrane
HPY13_11590	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HPY13_11595	ENOG4105D64	Mechanosensitive ion channel
HPY13_11600	ENOG4105D2N	Aldolase
HPY13_11605	ENOG4105BZA	Phosphoglycerate kinase
HPY13_11610	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY13_11615	ENOG4105D05	Receptor
HPY13_11620	ENOG4108R4R	Iron-regulated virulence regulatory protein
HPY13_11625	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY13_11630	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HPY13_11635	ENOG4105GPY	SprT protein
HPY13_11640	ENOG4105RWS	endonuclease I
HPY13_11645	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HPY13_11650	ENOG4105D7Z	glutathione synthase
HPY13_11655	ENOG4108UJU	UPF0301 protein
HPY13_11660	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPY13_11665	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY13_11675	ENOG4105CZX	twitching motility protein
HPY13_11680	ENOG4105CZX	twitching motility protein
HPY13_11685	ENOG4105DFA	alanine racemase domain protein
HPY13_11690	ENOG4105II7	pyrroline-5-carboxylate reductase
HPY13_11695	ENOG4108VIA	integral membrane protein
HPY13_11710	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HPY13_11715	ENOG4105CSA	Coproporphyrinogen iii oxidase
HPY13_11720	ENOG4105CSV	Glutaminase
HPY13_11725	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HPY13_11730	ENOG4105CEN	a g-specific adenine glycosylase
HPY13_11735	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HPY13_11740	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HPY13_11795	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HPY13_11800	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HPY13_11805	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HPY13_11810	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HPY13_11815	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HPY13_11820	ENOG4105NWN	ApaG protein
HPY13_11825	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HPY13_11835	ENOG4107XM3	UPF0442 protein
HPY13_11840	ENOG4105DWK	Membrane
HPY13_11845	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY13_11850	ENOG4105K46	50S ribosomal protein l27
HPY13_11855	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPY13_11860	ENOG4105EAH	synthase
HPY13_11865	ENOG4105D5Q	Arginine ornithine antiporter
HPY13_11870	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HPY13_11875	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPY13_11880	ENOG4105H1G	trap transporter solute receptor taxi family
HPY13_11890	ENOG41081QV	Universal stress protein
HPY13_11910	ENOG4105CEU	Arginine dihydrolase
HPY13_11915	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HPY13_11925	ENOG4105QD6	exported protein
HPY13_11930	ENOG4105C03	ribonuclease
HPY13_11935	ENOG4108Z03	MAF-like protein
HPY13_11940	ENOG4105VQ7	Rod shape-determining protein MreD
HPY13_11945	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HPY13_11985	ENOG4105X0D	Fimbrial protein
HPY13_11995	ENOG4105D7Q	type ii secretion system
HPY13_12000	ENOG4107QHF	type ii secretion system protein e
HPY13_12015	ENOG4105E4G	Type IV pilus
HPY13_12035	ENOG41062P1	Diguanylate cyclase phosphodiesterase
HPY13_12040	ENOG4108UUM	single-stranded DNA-binding protein
HPY13_12045	ENOG41086KC	Transcriptional regulator
HPY13_12050	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HPY13_12055	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HPY13_12065	ENOG4105C5R	Aminotransferase
HPY13_12070	ENOG4105CFH	Aspartokinase
HPY13_12075	ENOG4105C3R	Methionine synthase
HPY13_12080	ENOG4105EEQ	Na H antiporter
HPY13_12145	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPY13_12150	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HPY13_12155	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HPY13_12175	ENOG4105P4Z	Phage shock protein G
HPY13_12180	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY13_12185	ENOG4105MYN	Zinc uptake regulation protein
HPY13_12200	ENOG4107QP8	phosphohexose isomerase
HPY13_12205	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HPY13_12210	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY13_12215	ENOG4105CDU	Replicative dna helicase
HPY13_12225	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPY13_12230	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPY13_12235	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HPY13_12240	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPY13_12245	ENOG4108UQY	Iron-storage protein
HPY13_12250	ENOG4105W53	bacterioferritin-associated ferredoxin
HPY13_12255	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY13_12260	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY13_12265	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPY13_12280	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPY13_12285	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HPY13_12290	ENOG4105WWK	YheO domain protein
HPY13_12295	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY13_12305	ENOG41069P5	Protein slyX homolog
HPY13_12315	ENOG4105EPW	hflc protein
HPY13_12320	ENOG4107QJR	hflk protein
HPY13_12325	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPY13_12330	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HPY13_12335	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPY13_12340	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HPY13_12345	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HPY13_12350	ENOG4105K8N	protein family UPF0079, ATPase
HPY13_12355	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HPY13_12405	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPY13_12410	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPY13_12415	ENOG4105DJ4	phosphatidylserine decarboxylase
HPY13_12420	ENOG4105C8P	)-transporter
HPY13_12430	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPY13_12435	ENOG41063SB	peptidase
HPY13_12445	ENOG41062JF	Transcriptional regulator
HPY13_12450	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HPY13_12455	ENOG4105E09	nadh pyrophosphatase
HPY13_12460	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HPY13_12470	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY13_12475	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY13_12480	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HPY13_12485	ENOG4108VZM	50s ribosomal protein L10
HPY13_12495	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HPY13_12500	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPY13_12505	ENOG4105PM1	preprotein translocase subunit SecE
HPY13_12510	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY13_12535	ENOG4105CS9	pantothenic acid kinase
HPY13_12540	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPY13_12545	ENOG4105D4A	Cell wall formation (By similarity)
HPY13_12555	ENOG4105JIM	Phosphatidylserine synthase
HPY13_12590	ENOG4107QK7	reductase
HPY13_12600	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HPY13_12610	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HPY13_12620	ENOG4105C1J	atp-dependent rna helicase
HPY13_12625	ENOG4105C9X	ppx gppa phosphatase
HPY13_12630	ENOG4105BZU	Histidine kinase
HPY13_12635	ENOG4105D8G	Major Facilitator superfamily
HPY13_12650	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY13_12655	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HPY13_12660	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HPY13_12665	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HPY13_12670	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY13_12675	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY13_12680	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HPY13_12685	ENOG4105DIQ	Transcriptional regulator
HPY13_12700	ENOG4105C01	Dihydroxy-acid dehydratase
HPY13_12705	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPY13_12710	ENOG4105C6Z	Gluconate
HPY13_12715	ENOG4108UHU	Aldolase
HPY13_12720	ENOG4105E0K	tonB-dependent siderophore receptor
HPY13_12735	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_12740	ENOG4105CXN	decarboxylase
HPY13_12745	ENOG4105D5Q	Arginine ornithine antiporter
HPY13_12750	ENOG4108M3R	transcriptional activator CadC
HPY13_12755	ENOG4105W1Y	Transcriptional regulator
HPY13_12770	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPY13_12780	ENOG4105K70	DNA-binding protein
HPY13_12810	ENOG4108MDC	(LipO)protein
HPY13_12820	ENOG4105E3R	(LipO)protein
HPY13_12825	ENOG4105R2J	Conserved Protein
HPY13_12830	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HPY13_12835	ENOG4108RG0	uracil-dna glycosylase
HPY13_12840	ENOG4105CUY	Mechanosensitive ion channel
HPY13_12845	ENOG4105CY0	Metallo-Beta-Lactamase
HPY13_12855	ENOG4105D3Q	Sugar transferase
HPY13_12930	ENOG4105F0R	Cytidylyltransferase
HPY13_12935	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HPY13_12940	ENOG4105C5E	polysaccharide biosynthesis protein
HPY13_12945	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY13_12955	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
HPY13_12965	ENOG4105SFE	lipopolysaccharide biosynthesis protein
HPY13_12970	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HPY13_12975	ENOG4107T94	Endo-14-beta-xylanase
HPY13_12985	ENOG4108RS6	transposase
HPY13_13000	ENOG4105XA0	heptosyltransferase ii
HPY13_13005	ENOG4108ST3	glycosyltransferase
HPY13_13010	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HPY13_13040	ENOG4105EXC	Acyl-transferase
HPY13_13045	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
HPY13_13050	ENOG4105DKP	glycosyl transferase, family 9
HPY13_13055	ENOG4106WTF	Glycosyl transferase, family 2
HPY13_13060	ENOG4105M5K	heptosyltransferase
HPY13_13065	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPY13_13070	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPY13_13080	ENOG4105W0E	50S ribosomal protein L33
HPY13_13085	ENOG4105KDC	50s ribosomal protein l28
HPY13_13090	ENOG4105W5Q	DNA repair protein (RadC
HPY13_13095	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_13100	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HPY13_13110	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HPY13_13115	ENOG4105D1S	lipid A biosynthesis
HPY13_13120	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HPY13_13125	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPY13_13130	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPY13_13135	ENOG4105DSJ	YicC domain protein
HPY13_13140	ENOG4108TEB	UPF0114 protein
HPY13_13145	ENOG4105C5Y	PTS System
HPY13_13150	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY13_13155	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HPY13_13165	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPY13_13170	ENOG4105FR1	rard protein
HPY13_13175	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY13_13180	ENOG4108DMH	HTH_ARAC
HPY13_13185	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY13_13190	ENOG4105C4R	Atp-dependent dna helicase
HPY13_13195	ENOG4105DGW	oligopeptidase A
HPY13_13200	ENOG4105D6S	protein involved in catabolism of external DNA
HPY13_13205	ENOG4105DC8	reductase
HPY13_13215	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY13_13220	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY13_13225	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPY13_13265	ENOG4105MPD	Cytochrome
HPY13_13270	ENOG4105C4R	Atp-dependent dna helicase
HPY13_13275	ENOG4105Y7M	Transcriptional regulator, TetR family
HPY13_13280	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPY13_13285	ENOG4105BZS	acriflavin resistance protein
HPY13_13290	ENOG4105W0Z	cytoplasmic protein
HPY13_13295	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HPY13_13300	ENOG4105EMY	transcriptional regulator
HPY13_13370	ENOG4108RR8	protoporphyrinogen oxidase
HPY13_13375	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY13_13380	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPY13_13385	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY13_13390	ENOG4105CHU	acetyl-coa acetyltransferase
HPY13_13395	ENOG4105F52	Transcriptional regulator
HPY13_13400	ENOG4105CZQ	inner membrane transport protein YdhC
HPY13_13410	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPY13_13415	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPY13_13420	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPY13_13425	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPY13_13430	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY13_13435	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY13_13445	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPY13_13450	ENOG410684E	atp synthase
HPY13_13455	ENOG4105FA0	parb-like partition protein
HPY13_13460	ENOG4107QJE	Chromosome Partitioning Protein
HPY13_13465	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPY13_13470	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HPY13_13480	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HPY13_13485	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPY13_13495	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HPY13_13510	ENOG4105E5Q	amino acid AbC transporter
HPY13_13515	ENOG4105EAB	amino acid AbC transporter
HPY13_13520	ENOG4106RMF	ParB family
HPY13_13550	ENOG4105CDY	transcriptional regulatory protein
HPY13_13555	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPY13_13560	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_13565	ENOG4108YYI	Protein of unknown function (DUF2810)
HPY13_13570	ENOG41061ZR	Transcriptional regulator
HPY13_13575	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HPY13_13580	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HPY13_13585	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPY13_13590	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY13_13595	ENOG4105CS6	Rhs element vgr protein
HPY13_13620	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY13_13630	ENOG4105C8P	)-transporter
HPY13_13635	ENOG4108Q67	UPF0319 protein
HPY13_13660	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_13680	ENOG4105EYK	Phosphatidylglycerophosphatase B
HPY13_13685	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HPY13_13710	ENOG4105D6U	Sodium Glutamate Symporter
HPY13_13715	ENOG4105YE1	PilZ domain
HPY13_13730	ENOG4106TD9	Diguanylate cyclase
HPY13_13745	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY13_13750	ENOG4107SEY	Conserved Protein
HPY13_13760	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY13_13765	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HPY13_13775	ENOG4105C1J	atp-dependent rna helicase
HPY13_13780	ENOG4105CUG	Oligopeptidase b
HPY13_13810	ENOG4105CVA	phosphate
HPY13_13815	ENOG4105C8U	phosphate abc transporter
HPY13_13820	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY13_13825	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY13_13830	ENOG4105BZU	Histidine kinase
HPY13_13845	ENOG4105DWD	nucleoside recognition domain protein
HPY13_13850	ENOG4105CHH	sulfate transporter
HPY13_13860	ENOG4105DR5	peptidase
HPY13_13865	ENOG4105BZU	Histidine kinase
HPY13_13870	ENOG4105EQ2	LysR family Transcriptional regulator
HPY13_13875	ENOG4105E5M	Multidrug resistance protein D
HPY13_13880	ENOG4108Z4X	TRANSCRIPTIONal
HPY13_13895	ENOG4105CK2	sodium dicarboxylate symporter
HPY13_13935	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HPY13_13940	ENOG4105D9R	oxidoreductase
HPY13_13950	ENOG4105BZU	Histidine kinase
HPY13_13955	ENOG4107VXZ	Hydrolase
HPY13_14025	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY13_14030	ENOG4108JUB	Transcriptional regulator
HPY13_14070	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HPY13_14075	ENOG4105C2J	ABC transporter
HPY13_14080	ENOG4105CNN	ABC, transporter
HPY13_14085	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPY13_14090	ENOG4108RVA	ribokinase
HPY13_14095	ENOG4105ETE	Transcriptional regulator (LacI family
HPY13_14100	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HPY13_14105	ENOG4108I5U	Uridine phosphorylase
HPY13_14115	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPY13_14120	ENOG4105CXY	transporter
HPY13_14135	ENOG4105CQZ	Histidine kinase
HPY13_14140	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY13_14155	ENOG4105D5U	fad dependent oxidoreductase
HPY13_14165	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPY13_14170	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY13_14175	ENOG4105KJM	monovalent cation h antiporter subunit g
HPY13_14180	ENOG41080TA	Multiple resistance and ph regulation protein f
HPY13_14185	ENOG4105SC1	monovalent cation H antiporter subunit E
HPY13_14190	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HPY13_14195	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HPY13_14200	ENOG4105D65	subunit l
HPY13_14210	ENOG4105Q9Y	Universal stress protein
HPY13_14240	ENOG4105BZU	Histidine kinase
HPY13_14245	ENOG4105VEQ	Cold shock protein
HPY13_14280	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPY13_14285	ENOG41069D7	Methyl-accepting chemotaxis
HPY13_14300	ENOG4105D9N	nucleoside
HPY13_14305	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY13_14315	ENOG4108JUA	Transcriptional regulator
HPY13_14320	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY13_14325	ENOG4105VEQ	Cold shock protein
HPY13_14345	ENOG4108UNF	response regulator
HPY13_14355	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HPY13_14360	ENOG4105C5I	Dehydrogenase
HPY13_14380	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY13_14390	ENOG4107UNZ	domain protein
HPY13_14395	ENOG4105C1J	atp-dependent rna helicase
HPY13_14400	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY13_14405	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HPY13_14410	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HPY13_14415	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY13_14420	ENOG4105BZU	Histidine kinase
HPY13_14430	ENOG4107S6Z	Na H antiporter
HPY13_14435	ENOG4105E5M	Multidrug resistance protein D
HPY13_14445	ENOG4105KUU	lipolytic protein G-D-S-L family
HPY13_14450	ENOG4106M3D	hemolysin
HPY13_14455	ENOG4108N3W	hemolysin secretion protein
HPY13_14460	ENOG4107IFA	Lipase (EC 3.1.1.3)
HPY13_14495	ENOG4105DHS	permease protein
HPY13_14500	ENOG4105CM4	permease protein
HPY13_14505	ENOG4108IPW	abc transporter atp-binding protein
HPY13_14525	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY13_14545	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY13_14555	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
HPY13_14565	ENOG4105CR8	Transcriptional regulator
HPY13_14580	ENOG4105ETX	regulatoR
HPY13_14590	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HPY13_14600	ENOG410667J	hydrolase
HPY13_14655	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY13_14660	ENOG4105BZU	Histidine kinase
HPY13_14685	ENOG4107QVI	Methyltransferase, type 11
HPY13_14700	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY13_14705	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_14715	ENOG4105DZ1	carboxypeptidase
HPY13_14735	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY13_14740	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HPY13_14745	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY13_14755	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HPY13_14765	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPY13_14770	ENOG41082NX	50s ribosomal protein l35
HPY13_14775	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPY13_14935	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY13_14960	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY13_14965	ENOG4105QNF	Outer membrane lipoprotein
HPY13_15090	ENOG4108HYG	acetyltransferase
HPY13_15100	ENOG4105VXN	addiction module toxin, RelE StbE family
HPY13_15135	ENOG4105D9U	N-acetyltransferase
HPY13_15165	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HPY13_15340	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HPY13_15410	ENOG4105KD7	acetyltransferase
HPY13_15555	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY13_15590	ENOG4108MK9	spermidine N(1)-acetyltransferase
HPY13_15645	ENOG41080ET	plasmid maintenance system killer protein
HPY13_15650	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
HPY13_15905	ENOG4108HYG	acetyltransferase
HPY13_15920	ENOG4105KD7	acetyltransferase
HPY13_15940	ENOG4108MK9	spermidine N(1)-acetyltransferase
HPY13_15955	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY13_15960	ENOG4105EST	Metal Dependent Phosphohydrolase
HPY13_15975	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY13_16010	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HPY13_16020	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HPY13_16025	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HPY13_16030	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY13_16035	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY13_16040	ENOG4105DM4	PTS System
HPY13_16045	ENOG4105DE4	1-phosphofructokinase
HPY13_16050	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HPY13_16055	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPY13_16060	ENOG4107RFY	SbcCD D subunit
HPY13_16065	ENOG4105EYH	Exonuclease
HPY13_16070	ENOG4108MGY	Histidine kinase
HPY13_16075	ENOG4107KBT	8-Amino-7-oxononanoate synthase
HPY13_16085	ENOG4105CMQ	Chloride channel
HPY13_16090	ENOG4105CKI	cobalamin synthesis protein
HPY13_16095	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HPY13_16100	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HPY13_16105	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HPY13_16110	ENOG4105C08	Histidine kinase
HPY13_16115	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HPY13_16120	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY13_16125	ENOG4108RHM	integral membrane protein
HPY13_16135	ENOG4105EPM	Diguanylate phosphodiesterase
HPY13_16145	ENOG4105DS1	cytochrome b561
HPY13_16155	ENOG4105TMB	Formate nitrite transporter
HPY13_16160	ENOG4105DUM	transcriptional regulator, lysR family
HPY13_16165	ENOG4108UQ5	membrane protein YcdZ
HPY13_16170	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
HPY13_16175	ENOG4105CGH	5'-nucleotidase
HPY13_16180	ENOG4105DU1	integral membrane protein, terc
HPY13_16190	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HPY13_16220	ENOG4105BZU	Histidine kinase
HPY13_16230	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY13_16240	ENOG4105BZU	Histidine kinase
HPY13_16255	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY13_16260	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY13_16270	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY13_16355	ENOG4108ZJT	translation initiation factor, Sui1
HPY13_16375	ENOG4105CD5	CoA-binding domain protein
HPY13_16380	ENOG4105CWB	LysR family transcriptional Regulator
HPY13_16400	ENOG4105KA0	thioesterase Superfamily protein
HPY13_16420	ENOG4105CYM	Glutathione S-transferase
HPY13_16435	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY13_16440	ENOG4108JQ5	ABC transporter
HPY13_16445	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPY13_16450	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HPY13_16455	ENOG4105E43	Extracellular solute-binding protein, family 5
HPY13_16480	ENOG4105DUX	Transporter
HPY13_16495	ENOG4107RCV	ABC transporter, permease
HPY13_16510	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HPY13_16515	ENOG4108JPW	Aminotransferase
HPY13_16520	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HPY13_16525	ENOG4105NXH	GreA GreB family elongation factor
HPY13_16530	ENOG4105PAD	Hydrolase
HPY13_16540	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HPY13_16545	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HPY13_16550	ENOG4105CKU	formyltetrahydrofolate synthetase
HPY13_16555	ENOG4105E0X	reductase
HPY13_16560	ENOG4105EUJ	GTP cyclohydrolase i
HPY13_16565	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY13_16570	ENOG4105D06	uba thif-type nad fad binding protein
HPY13_16580	ENOG4105KHC	sulfurtransferase
HPY13_16585	ENOG4107RHR	regulatoR
HPY13_16595	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY13_16620	ENOG4108M3J	Dehydrogenase
HPY13_16635	ENOG4105RA2	Membrane
HPY13_16645	ENOG4105ETT	transcriptional Regulator, LysR family
HPY13_16650	ENOG41067V3	Antibiotic biosynthesis monooxygenase
HPY13_16655	ENOG4108RCM	Nitroreductase
HPY13_16680	ENOG41080HT	Transcriptional regulator, arsr family
HPY13_16700	ENOG4105CAF	HipA N-terminal domain protein
HPY13_16720	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY13_16725	ENOG41082YX	Transcriptional regulator, arsr family
HPY13_16735	ENOG4105PWN	phosphate abc transporter
HPY13_16740	ENOG4105C8U	phosphate abc transporter
HPY13_16760	ENOG4105CHH	sulfate transporter
HPY13_16770	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY13_16800	ENOG4105D6J	arsenicaL-resistance protein
HPY13_16805	ENOG41082YX	Transcriptional regulator, arsr family
HPY13_16810	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPY13_16815	ENOG4105KT5	UmuD protein
HPY13_16840	ENOG4108HYK	gCN5-related N-acetyltransferase
HPY13_16865	ENOG4105BZU	Histidine kinase
HPY13_16910	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HPY13_16970	ENOG4108SAU	DNA-binding protein H-ns
HPY13_17010	ENOG4105CVR	type I restriction-modification system
HPY13_17025	ENOG4108RS6	transposase
HPY13_17040	ENOG4105FDR	Membrane
HPY13_17045	ENOG4108Z4X	TRANSCRIPTIONal
HPY13_17050	ENOG41090EM	Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter
HPY13_17055	ENOG41061MD	high-affinity nickel-transporter
HPY13_17060	ENOG4105C08	Histidine kinase
HPY13_17065	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HPY13_17070	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY13_17080	ENOG4105CZN	Potassium uptake protein
HPY13_17120	ENOG4107TII	Recombinase
HPY13_17125	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HPY13_17170	ENOG4105C5Y	PTS System
HPY13_17175	ENOG4105ETE	Transcriptional regulator (LacI family
HPY13_17180	ENOG4108HKT	sucrose-6-phosphate hydrolase
HPY13_17185	ENOG4105D7K	pfkb domain protein
HPY13_17190	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPY13_17195	ENOG4108NVR	Methyl-accepting chemotaxis
HPY13_17200	ENOG4108ZG0	Ompa motb domain protein
HPY13_17205	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY13_17210	ENOG4107VXZ	Hydrolase
HPY13_17215	ENOG4108N3W	hemolysin secretion protein
HPY13_17220	ENOG4105CEE	C4-dicarboxylate transporter
HPY13_17225	ENOG4105EJQ	L-serine dehydratase
HPY13_17245	ENOG4105ETE	Transcriptional regulator (LacI family
HPY13_17250	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY13_17255	ENOG4105BZU	Histidine kinase
HPY13_17270	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY13_17290	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY13_17295	ENOG4108KX4	response regulator
HPY13_17300	ENOG4105BZU	Histidine kinase
HPY13_17305	ENOG4105CXY	transporter
HPY13_17310	ENOG4105C4Y	ABC transporter
HPY13_17315	ENOG4107RCV	ABC transporter, permease
HPY13_17320	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY13_17325	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HPY13_17335	ENOG4105CHU	acetyl-coa acetyltransferase
HPY13_17345	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY13_17350	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY13_17365	ENOG4105BZU	Histidine kinase
HPY13_17370	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY13_17380	ENOG4108I6A	alcohol dehydrogenase
HPY13_17390	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
HPY13_17400	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
HPY13_17405	ENOG4105CXY	transporter
HPY13_17410	ENOG4105CA9	Pyruvate kinase
HPY13_17415	ENOG4105BZU	Histidine kinase
HPY13_17420	ENOG4108SV3	Tmao reductase system periplasmic protein tort
HPY13_17425	ENOG4108Z5K	methylglyoxal synthase
HPY13_17430	ENOG4108RWI	nicotinamidase
HPY13_17435	ENOG41080IJ	Diacylglycerol kinase
HPY13_17440	ENOG41088T4	Helicase IV
HPY13_17445	ENOG4105EM2	membrane
HPY13_17475	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HPY13_17480	ENOG4105E0C	molybdate abc transporter
HPY13_17485	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HPY13_17490	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HPY13_17520	ENOG4105BZU	Histidine kinase
HPY13_17525	ENOG4108QGH	periplasmic
HPY13_17535	ENOG41082IR	Excinuclease ABC C subunit domain protein
HPY13_17550	ENOG41090HJ	UPF0265 protein
HPY13_17560	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HPY13_17565	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPY13_17570	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HPY13_17575	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HPY13_17580	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPY13_17585	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY13_17590	ENOG4105K63	Thioredoxin
HPY13_17615	ENOG4105DMR	ABC, transporter
HPY13_17620	ENOG4105GBT	ABC transporter
HPY13_17625	ENOG4106PMH	Extracellular solute-binding protein family 3
HPY13_17630	ENOG4105E5Z	arginine transporter ATP-binding subunit
HPY13_17640	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HPY13_17650	ENOG4108YZ4	nudix hydrolase
HPY13_17655	ENOG4105C5W	Aldolase
HPY13_17660	ENOG4106RE7	Cytochrome
HPY13_17665	ENOG4107XI7	Tetr family transcriptional regulator
HPY13_17670	ENOG4105C1J	atp-dependent rna helicase
HPY13_17675	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HPY13_17680	ENOG4105E0U	tyrosine-specific transport protein
HPY13_17685	ENOG4108N3W	hemolysin secretion protein
HPY13_17690	ENOG4105CMR	udp-glucose 4-epimerase
HPY13_17695	ENOG4105E7W	lamb ycsf family protein
HPY13_17705	ENOG4107R7A	Allophanate hydrolase subunit 2
HPY13_17715	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HPY13_17720	ENOG4105CV6	ABC transporter, permease
HPY13_17725	ENOG4108I0Y	(ABC) transporter
HPY13_17735	ENOG4105RKW	reductase (By
HPY13_17750	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY13_17765	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY13_17780	ENOG4107RE1	Inosine-guanosine kinase
HPY13_17785	ENOG4105E0M	Sulfatase
HPY13_17795	ENOG4105C1J	atp-dependent rna helicase
HPY13_17810	ENOG4105CVA	phosphate
HPY13_17820	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HPY13_17825	ENOG4108M1A	Chitin-binding protein
HPY13_17845	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HPY13_17855	ENOG4105CJW	magnesium transporter
HPY13_17860	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY13_17865	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY13_17875	ENOG4105CZK	Aspartate kinase
HPY13_17880	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
HPY13_17885	ENOG4108JPW	Aminotransferase
HPY13_17890	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY13_17895	ENOG41090A4	Pterin carbinolamine dehydratase
HPY13_17900	ENOG4105MIR	Phenylalanine 4-monooxygenase
HPY13_17905	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY13_17920	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY13_17925	ENOG4105EGI	Transcriptional regulator
HPY13_17945	ENOG4105C37	(CBS) domain
HPY13_17950	ENOG4108UKZ	OsmC family
HPY13_17955	ENOG4107YWA	deoxycytidylate deaminase
HPY13_17985	ENOG4105DVH	amino acid
HPY13_17990	ENOG4106TD9	Diguanylate cyclase
HPY13_18000	ENOG4108VAC	response regulator
HPY13_18005	ENOG4108HRK	Histidine kinase
HPY13_18020	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY13_18025	ENOG4105C19	ABC transporter
HPY13_18035	ENOG4107RGM	aldo keto reductase
HPY13_18040	ENOG4107T9C	Alpha amylase catalytic region
HPY13_18050	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY13_18055	ENOG4108M0H	Extracellular lipase
HPY13_18060	ENOG4107SDU	Methyl-accepting chemotaxis
HPY13_18065	ENOG4105D4Y	metalloprotease
HPY13_18070	ENOG4105EIF	outer membrane protein W
HPY13_18080	ENOG41061WM	D-Alanyl-D-Alanine
HPY13_18085	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY13_18090	ENOG4105VEQ	Cold shock protein
HPY13_18100	ENOG4105BZC	d-serine deaminase
HPY13_18105	ENOG4105W8I	Transcriptional regulator
HPY13_18125	ENOG4105CPQ	Dehydrogenase
HPY13_18130	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY13_18135	ENOG4108IQK	o-acetylhomoserine
HPY13_18140	ENOG4105EXG	Transcriptional regulator
HPY13_18145	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HPY13_18165	ENOG4107SSZ	Phosphatase
HPY13_18175	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HPY13_18180	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HPY13_18185	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPY13_18210	ENOG4105BZW	Glycerate kinase
HPY13_18215	ENOG4105C6Z	Gluconate
HPY13_18225	ENOG4108NVR	Methyl-accepting chemotaxis
HPY13_18230	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HPY13_18235	ENOG41090JE	Utilization Protein
HPY13_18240	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY13_18245	ENOG4105WQ5	TonB family
HPY13_18250	ENOG41090AP	transport protein
HPY13_18255	ENOG4106GFD	transport protein
HPY13_18260	ENOG4107R4I	Periplasmic binding protein
HPY13_18265	ENOG4105EHG	Permease protein
HPY13_18270	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY13_18300	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_18305	ENOG4105QVC	MOSC domain-containing protein
HPY13_18305	ENOG4105QVC	MOSC domain-containing protein
HPY13_18310	ENOG4105EKE	dihydroorotase
HPY13_18320	ENOG4105KAF	membrAne
HPY13_18330	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
HPY13_18335	ENOG4105CKW	Inner membrane protein yedI
HPY13_18345	ENOG4108ESY	Metal dependent phosphohydrolase
HPY13_18350	ENOG4105VEQ	Cold shock protein
HPY13_18375	ENOG4105BZU	Histidine kinase
HPY13_18380	ENOG4105E98	transcriptional regulator DeoR family
HPY13_18395	ENOG4105EG2	ABC transporter, permease
HPY13_18400	ENOG4105D56	permease protein
HPY13_18405	ENOG4107FKK	extracellular solute-binding protein family 1
HPY13_18410	ENOG4108IJ9	(ABC) transporter
HPY13_18415	ENOG4108HK0	-acetyltransferase
HPY13_18430	ENOG4105K8R	UPF0145 protein
HPY13_18435	ENOG41086KC	Transcriptional regulator
HPY13_18440	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HPY13_18450	ENOG4105K56	Transcriptional regulator
HPY13_18455	ENOG4106TD9	Diguanylate cyclase
HPY13_18470	ENOG4105BZU	Histidine kinase
HPY13_18490	ENOG4105ETT	transcriptional Regulator, LysR family
HPY13_18495	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY13_18505	ENOG4105EUB	pirin domain protein
HPY13_18510	ENOG4105NBK	UPF0345 protein
HPY13_18520	ENOG4105E5W	Transporter
HPY13_18525	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_18530	ENOG4105DAN	ATP-dependent protease
HPY13_18540	ENOG4108JQ5	ABC transporter
HPY13_18545	ENOG4105E89	ABC transporter
HPY13_18550	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_18560	ENOG4105CC0	LysR family Transcriptional regulator
HPY13_18570	ENOG4105DAA	L-lactate
HPY13_18585	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HPY13_18595	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HPY13_18605	ENOG4105C1J	atp-dependent rna helicase
HPY13_18610	ENOG4105ECQ	AraC Family Transcriptional Regulator
HPY13_18615	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HPY13_18625	ENOG4105BZ1	(ABC) transporter
HPY13_18635	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY13_18645	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY13_18670	ENOG4105K56	Transcriptional regulator
HPY13_18675	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HPY13_18685	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY13_18690	ENOG4105VW4	glutaredoxin 3
HPY13_18695	ENOG4108P2H	Inner membrane protein YjiG
HPY13_18700	ENOG41074DU	domain protein
HPY13_18705	ENOG4105DN9	Na H antiporter
HPY13_18710	ENOG4106YYS	transcriptional regulatory protein
HPY13_18715	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY13_18720	ENOG4107QPK	)-transporter
HPY13_18730	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPY13_18740	ENOG4108VGI	doxx family
HPY13_18765	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPY13_18770	ENOG4108RS6	transposase
HPY13_18780	ENOG4107W52	maltose operon periplasmic protein
HPY13_18785	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPY13_18800	ENOG4108N3W	hemolysin secretion protein
HPY13_18810	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_18820	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY13_18825	ENOG4105CDA	abc transporter atp-binding protein
HPY13_18835	ENOG4106TNF	Periplasmic binding protein
HPY13_18840	ENOG4105EZ7	amino acid ABC transporter
HPY13_18845	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HPY13_18850	ENOG4105CTS	PTS system mannitol-specific
HPY13_18855	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HPY13_18860	ENOG4105E61	Mannitol repressor protein
HPY13_18865	ENOG4105EP9	oxidoreductase
HPY13_18890	ENOG4108KTG	Membrane protein, drug metabolite transporter
HPY13_18915	ENOG4108RYK	Nad-dependent epimerase dehydratase
HPY13_18920	ENOG4105JQN	Transcriptional regulator
HPY13_18930	ENOG4105EMU	Dehydrogenase
HPY13_18935	ENOG4105JQN	Transcriptional regulator
HPY13_18955	ENOG4105D5Q	Arginine ornithine antiporter
HPY13_18960	ENOG4105CXN	decarboxylase
HPY13_18970	ENOG4107RGH	Aldehyde dehydrogenase
HPY13_18975	ENOG4105EW9	transcriptional regulator AsnC family
HPY13_18980	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_18990	ENOG4105CK7	Sodium proline symporter
HPY13_19000	ENOG4105C26	Dehydrogenase
HPY13_19015	ENOG4105E6M	Sulphatase-modifying factor protein
HPY13_19030	ENOG4107QZV	Type I secretion membrane fusion protein
HPY13_19045	ENOG4108JJA	ABC, transporter
HPY13_19055	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY13_19065	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_19070	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY13_19080	ENOG4105BZU	Histidine kinase
HPY13_19085	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY13_19090	ENOG4108V3W	Chemotaxis protein, CheW
HPY13_19095	ENOG4108V3W	Chemotaxis protein, CheW
HPY13_19100	ENOG4105CBS	Chea signal transduction histidine kinase
HPY13_19105	ENOG4108VYJ	response regulator receiver protein
HPY13_19120	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY13_19125	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY13_19130	ENOG4108JQ6	ABC transporter
HPY13_19135	ENOG4105DIJ	Phosphoethanolamine transferase
HPY13_19140	ENOG4105DHQ	Histidine kinase
HPY13_19145	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY13_19175	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HPY13_19180	ENOG4107RUE	extracellular solute-binding protein family 1