locus-tag	class	description
HPY06_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY06_00010	COG0592	DNA-directed DNA polymerase activity
HPY06_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY06_00020	COG0187	DNA topoisomerase II activity
HPY06_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY06_00035	COG3977	Valine--pyruvate aminotransferase
HPY06_00040	COG0751	glycine-tRNA ligase activity
HPY06_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY06_00050	COG2119	membrane
HPY06_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY06_00070	COG0604	alcohol dehydrogenase
HPY06_00080	COG0129	dihydroxy-acid dehydratase activity
HPY06_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY06_00100	COG0606	chelatase, subunit chli
HPY06_00105	COG0204	Acyl-transferase
HPY06_00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY06_00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY06_00130	COG3084	Protein conserved in bacteria
HPY06_00135	COG4326	sporulation control protein
HPY06_00140	COG1272	protein, Hemolysin III
HPY06_00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY06_00155	COG0569	domain protein
HPY06_00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY06_00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY06_00165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY06_00170	COG0242	peptide deformylase activity
HPY06_00175	COG1652	LysM domain
HPY06_00180	COG0758	DNA mediated transformation
HPY06_00185	COG2922	Belongs to the Smg family
HPY06_00190	COG0551	DNA topoisomerase type I activity
HPY06_00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY06_00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY06_00205	COG0009	L-threonylcarbamoyladenylate synthase
HPY06_00210	COG0408	coproporphyrinogen oxidase activity
HPY06_00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY06_00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY06_00265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY06_00270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY06_00280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY06_00285	COG2104	thiamine diphosphate biosynthetic process
HPY06_00290	COG2022	thiamine diphosphate biosynthetic process
HPY06_00295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY06_00300	COG0006	proline dipeptidase activity
HPY06_00300	COG0006	proline dipeptidase activity
HPY06_00320	COG1522	sequence-specific DNA binding
HPY06_00325	COG5001	Diguanylate cyclase
HPY06_00325	COG5002	protein histidine kinase activity
HPY06_00345	COG0589	response to stress
HPY06_00350	COG1528	Iron-storage protein
HPY06_00360	COG2081	HI0933 family
HPY06_00370	COG1322	Protein conserved in bacteria
HPY06_00375	COG2226	methyltransferase
HPY06_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY06_00395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY06_00400	COG0805	protein transport
HPY06_00405	COG1858	cytochrome C peroxidase
HPY06_00410	COG0534	Mate efflux family protein
HPY06_00420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY06_00425	COG2937	Belongs to the GPAT DAPAT family
HPY06_00430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY06_00435	COG3161	chorismate lyase activity
HPY06_00440	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY06_00445	COG0840	transmembrane signaling receptor activity
HPY06_00455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY06_00460	COG0084	hydrolase, TatD family'
HPY06_00475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY06_00475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY06_00495	COG3078	GTPase activator activity
HPY06_00510	COG3071	HemY protein
HPY06_00515	COG2959	enzyme of heme biosynthesis
HPY06_00520	COG1587	Uroporphyrinogen-III synthase
HPY06_00525	COG0181	hydroxymethylbilane synthase activity
HPY06_00535	COG1965	Belongs to the frataxin family
HPY06_00545	COG0019	diaminopimelate decarboxylase activity
HPY06_00550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY06_00560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY06_00565	COG1011	Hydrolase
HPY06_00570	COG2200	EAL domain
HPY06_00570	COG3287	FIST C domain
HPY06_00570	COG2199	diguanylate cyclase activity
HPY06_00585	COG0561	phosphatase activity
HPY06_00590	COG2267	carboxylic ester hydrolase activity
HPY06_00595	COG1280	lysine exporter protein (LysE YggA)
HPY06_00600	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY06_00605	COG0783	Belongs to the Dps family
HPY06_00635	COG0742	ribosomal rna small subunit methyltransferase
HPY06_00640	COG0552	protein localization to endoplasmic reticulum
HPY06_00645	COG2884	Cell division ATP-binding protein ftsE
HPY06_00650	COG2177	Part of the ABC transporter FtsEX involved in
HPY06_00655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY06_00660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_00675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY06_00680	COG4206	TonB-dependent receptor
HPY06_00685	COG1404	Belongs to the peptidase S8 family
HPY06_00690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY06_00755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY06_00760	COG5001	Diguanylate cyclase
HPY06_00760	COG3300	MHYT domain
HPY06_00770	COG3852	Histidine kinase
HPY06_00780	COG0174	glutamine synthetase
HPY06_00800	COG1295	ribonuclease BN
HPY06_00805	COG1490	D-aminoacyl-tRNA deacylase activity
HPY06_00810	COG0456	acetyltransferase
HPY06_00820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY06_00825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY06_00830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY06_00835	COG3031	protein transport across the cell outer membrane
HPY06_00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY06_00850	COG1459	type II secretion system
HPY06_00855	COG2165	general secretion pathway protein
HPY06_00860	COG2165	general secretion pathway protein
HPY06_00865	COG2165	general secretion pathway protein
HPY06_00870	COG4795	General secretion pathway protein
HPY06_00875	COG3156	type II secretion system protein K
HPY06_00880	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY06_00885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY06_00895	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY06_00900	COG0494	nUDIX hydrolase
HPY06_00910	COG1040	competence protein
HPY06_00920	COG0596	Alpha beta hydrolase
HPY06_00930	COG2183	response to ionizing radiation
HPY06_00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY06_00940	COG2199	diguanylate cyclase activity
HPY06_00945	COG0745	RESPONSE REGULATOR receiver
HPY06_00955	COG2233	PERMEase
HPY06_00960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY06_00965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY06_00970	COG1758	RNA polymerase activity
HPY06_00975	COG0194	GDP metabolic process
HPY06_00980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY06_00985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY06_01005	COG4232	protein-disulfide reductase activity
HPY06_01020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY06_01025	COG1027	Aspartate ammonia-lyase
HPY06_01030	COG3706	GGDEF domain
HPY06_01035	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY06_01040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY06_01050	COG2205	protein histidine kinase activity
HPY06_01055	COG0745	RESPONSE REGULATOR receiver
HPY06_01065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY06_01070	COG0205	6-phosphofructokinase activity
HPY06_01075	COG1494	fructose-1,6-bisphosphatase
HPY06_01080	COG3074	FtsZ-dependent cytokinesis
HPY06_01085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY06_01090	COG0460	homoserine dehydrogenase
HPY06_01090	COG0527	aspartate kinase activity
HPY06_01095	COG0626	cystathionine gamma-synthase activity
HPY06_01100	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY06_01105	COG0281	malic enzyme
HPY06_01110	COG0254	rRNA binding
HPY06_01115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY06_01120	COG1609	Transcriptional regulator
HPY06_01125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY06_01130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY06_01135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY06_01140	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY06_01145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY06_01150	COG0534	Mate efflux family protein
HPY06_01155	COG0149	triose-phosphate isomerase activity
HPY06_01180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY06_01185	COG0459	protein refolding
HPY06_01195	COG3344	reverse transcriptase
HPY06_01210	COG1509	lysine 2,3-aminomutase activity
HPY06_01215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY06_01225	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY06_01230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY06_01235	COG1053	succinate dehydrogenase
HPY06_01240	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY06_01245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY06_01250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY06_01255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY06_01260	COG1045	serine acetyltransferase
HPY06_01270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY06_01275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY06_01280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY06_01285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY06_01290	COG0137	argininosuccinate synthase activity
HPY06_01295	COG0165	Argininosuccinate lyase
HPY06_01305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_01310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY06_01310	COG0678	peroxiredoxin activity
HPY06_01320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY06_01350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY06_01355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY06_01365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY06_01370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY06_01375	COG0546	phosphoglycolate phosphatase activity
HPY06_01380	COG0180	Tryptophanyl-tRNA synthetase
HPY06_01395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY06_01405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY06_01430	COG3954	Phosphoribulokinase
HPY06_01440	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY06_01450	COG0488	(ABC) transporter
HPY06_01455	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY06_01470	COG1047	Peptidyl-prolyl cis-trans
HPY06_01480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY06_01485	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY06_01490	COG3083	sulfuric ester hydrolase activity
HPY06_01495	COG0557	exoribonuclease II activity
HPY06_01500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY06_01505	COG0051	transcription antitermination factor activity, RNA binding
HPY06_01510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY06_01515	COG0088	Forms part of the polypeptide exit tunnel
HPY06_01520	COG0089	rRNA binding
HPY06_01525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY06_01530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY06_01535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY06_01540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY06_01545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY06_01550	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY06_01555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY06_01560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY06_01565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY06_01570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY06_01575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY06_01580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY06_01585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY06_01590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY06_01595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY06_01600	COG1841	ribosomal large subunit assembly
HPY06_01610	COG0201	protein transport
HPY06_01615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY06_01620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY06_01625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY06_01630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY06_01635	COG0202	RNA polymerase activity
HPY06_01640	COG0203	ribosomal protein L17
HPY06_01650	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY06_01655	COG3061	Opacity-associated protein A
HPY06_01655	COG3266	domain, Protein
HPY06_01660	COG0697	spore germination
HPY06_01665	COG2153	protein acetylation
HPY06_01670	COG0513	Belongs to the DEAD box helicase family
HPY06_01680	COG0737	Belongs to the 5'-nucleotidase family
HPY06_01685	COG1648	precorrin-2 dehydrogenase activity
HPY06_01685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY06_01690	COG0175	sulfate reduction
HPY06_01695	COG2895	sulfate adenylyltransferase (ATP) activity
HPY06_01700	COG0529	Catalyzes the synthesis of activated sulfate
HPY06_01720	COG1136	(ABC) transporter
HPY06_01735	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY06_01740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_01745	COG0729	surface antigen
HPY06_01755	COG2105	PFAM AIG2 family protein
HPY06_01760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY06_01770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY06_01775	COG0163	prenyltransferase activity
HPY06_01785	COG1178	ABC-type Fe3 transport system permease component
HPY06_01790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY06_01795	COG3028	Belongs to the UPF0307 family
HPY06_01800	COG0312	modulator of DNA gyrase
HPY06_01805	COG2239	Acts as a magnesium transporter
HPY06_01810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_01815	COG1660	Displays ATPase and GTPase activities
HPY06_01820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_01825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY06_01835	COG1137	ATPase activity
HPY06_01840	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY06_01855	COG0517	IMP dehydrogenase activity
HPY06_01855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY06_01865	COG1127	ABC transporter
HPY06_01870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY06_01875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY06_01880	COG2854	intermembrane phospholipid transfer
HPY06_01890	COG5007	Belongs to the BolA IbaG family
HPY06_01895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY06_01905	COG0251	oxidation-reduction process
HPY06_01915	COG0540	Belongs to the ATCase OTCase family
HPY06_01925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY06_01930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY06_01935	COG0564	pseudouridine synthase activity
HPY06_01940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY06_01945	COG0525	valine-tRNA ligase activity
HPY06_01950	COG2927	DNA polymerase III (CHI subunit)
HPY06_01955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY06_01960	COG0795	lipopolysaccharide-transporting ATPase activity
HPY06_01965	COG0795	lipopolysaccharide-transporting ATPase activity
HPY06_01980	COG3437	response regulator, receiver
HPY06_02020	COG0066	3-isopropylmalate dehydratase activity
HPY06_02025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY06_02030	COG0473	3-isopropylmalate dehydrogenase activity
HPY06_02050	COG0583	DNA-binding transcription factor activity
HPY06_02055	COG1022	Amp-dependent synthetase and ligase
HPY06_02060	COG0028	Belongs to the TPP enzyme family
HPY06_02065	COG0440	acetolactate synthase activity
HPY06_02070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY06_02075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY06_02080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY06_02090	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY06_02095	COG3079	Belongs to the UPF0149 family
HPY06_02100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_02105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_02115	COG0354	folic acid binding
HPY06_02120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY06_02130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY06_02135	COG1595	DNA-templated transcription, initiation
HPY06_02150	COG3086	response to oxidative stress
HPY06_02155	COG0481	GTPase activity
HPY06_02165	COG0571	ribonuclease III activity
HPY06_02170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY06_02175	COG1381	Involved in DNA repair and RecF pathway recombination
HPY06_02180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY06_02185	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY06_02200	COG5001	Diguanylate cyclase
HPY06_02205	COG3437	response regulator, receiver
HPY06_02205	COG4999	Histidine kinase
HPY06_02205	COG2205	protein histidine kinase activity
HPY06_02205	COG3850	Histidine kinase
HPY06_02215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY06_02220	COG3956	TIGRFAM MazG family protein
HPY06_02225	COG0504	CTP synthase activity
HPY06_02230	COG0148	phosphopyruvate hydratase activity
HPY06_02235	COG0617	tRNA 3'-terminal CCA addition
HPY06_02240	COG3267	Type II secretory pathway component ExeA
HPY06_02240	COG3409	Peptidoglycan-binding domain 1 protein
HPY06_02250	COG4991	sh3 domain protein
HPY06_02255	COG0306	phosphate transporter
HPY06_02260	COG1392	Phosphate transport regulator
HPY06_02265	COG3025	triphosphatase activity
HPY06_02270	COG0840	transmembrane signaling receptor activity
HPY06_02275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY06_02280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY06_02280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY06_02285	COG1538	Outer membrane efflux protein
HPY06_02290	COG0494	nUDIX hydrolase
HPY06_02295	COG3151	Protein conserved in bacteria
HPY06_02305	COG3150	esterase
HPY06_02310	COG0187	DNA topoisomerase II activity
HPY06_02315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY06_02325	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY06_02330	COG0237	dephospho-CoA kinase activity
HPY06_02340	COG1459	type II secretion system
HPY06_02345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY06_02355	COG0157	Belongs to the NadC ModD family
HPY06_02370	COG0716	FMN binding
HPY06_02375	COG4974	Belongs to the 'phage' integrase family
HPY06_02380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY06_02385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY06_02390	COG2186	Transcriptional regulator
HPY06_02395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY06_02400	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY06_02405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_02420	COG3116	cell division
HPY06_02425	COG0768	penicillin binding
HPY06_02430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY06_02435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY06_02445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY06_02450	COG0772	Belongs to the SEDS family
HPY06_02455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY06_02460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY06_02465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY06_02470	COG0849	cell division
HPY06_02475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY06_02480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY06_02490	COG0653	protein targeting
HPY06_02495	COG0494	nUDIX hydrolase
HPY06_02500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY06_02510	COG0505	Belongs to the CarA family
HPY06_02515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY06_02530	COG0730	response to heat
HPY06_02535	COG0583	DNA-binding transcription factor activity
HPY06_02540	COG2860	membrane
HPY06_02545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY06_02555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY06_02565	COG0493	'glutamate synthase
HPY06_02570	COG0070	glutamate synthase
HPY06_02570	COG0069	glutamate synthase activity
HPY06_02570	COG0067	glutamate synthase
HPY06_02580	COG0069	glutamate synthase activity
HPY06_02580	COG0070	glutamate synthase
HPY06_02580	COG0067	glutamate synthase
HPY06_02585	COG1242	4 iron, 4 sulfur cluster binding
HPY06_02590	COG5001	Diguanylate cyclase
HPY06_02590	COG4251	negative regulation of phosphorylation
HPY06_02590	COG2203	Gaf domain
HPY06_02590	COG3706	GGDEF domain
HPY06_02595	COG5002	protein histidine kinase activity
HPY06_02595	COG0784	Response regulator, receiver
HPY06_02595	COG2198	Histidine kinase
HPY06_02600	COG0745	RESPONSE REGULATOR receiver
HPY06_02610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY06_02630	COG0083	homoserine kinase activity
HPY06_02635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY06_02640	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY06_02645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY06_02650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY06_02665	COG1115	amino acid carrier protein
HPY06_02670	COG3022	response to hydroperoxide
HPY06_02680	COG0084	hydrolase, TatD family'
HPY06_02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY06_02695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY06_02700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY06_02705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY06_02710	COG0813	purine-nucleoside phosphorylase activity
HPY06_02720	COG0560	Phosphoserine phosphatase
HPY06_02730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY06_02735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY06_02740	COG1022	Amp-dependent synthetase and ligase
HPY06_02755	COG3250	beta-galactosidase activity
HPY06_02760	COG1609	Transcriptional regulator
HPY06_02765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_02780	COG0569	domain protein
HPY06_02780	COG0189	ligase activity
HPY06_02785	COG0456	acetyltransferase
HPY06_02795	COG2171	N-acyltransferase activity
HPY06_02800	COG3141	response to X-ray
HPY06_02815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY06_02820	COG1074	ATP-dependent DNA helicase activity
HPY06_02825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY06_02835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY06_02835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY06_02845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY06_02850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY06_02855	COG2166	iron-sulfur cluster assembly
HPY06_02860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY06_02865	COG0693	protein deglycase activity
HPY06_02870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY06_02875	COG3248	Nucleoside-binding outer membrane protein
HPY06_02885	COG1595	DNA-templated transcription, initiation
HPY06_02895	COG2211	Major facilitator Superfamily
HPY06_02910	COG2813	Specifically methylates the guanine in position
HPY06_02915	COG0271	Belongs to the BolA IbaG family
HPY06_02920	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_02925	COG1805	sodium ion transport
HPY06_02930	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_02935	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_02940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_02945	COG2871	sodium ion transport
HPY06_02950	COG1477	protein flavinylation
HPY06_02970	COG3706	GGDEF domain
HPY06_02975	COG0733	neurotransmitter:sodium symporter activity
HPY06_02985	COG0189	ligase activity
HPY06_02990	COG0189	ligase activity
HPY06_02990	COG4067	protein conserved in archaea
HPY06_02995	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY06_03000	COG2252	PERMEase
HPY06_03005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY06_03020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY06_03025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY06_03030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY06_03035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY06_03035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY06_03050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY06_03055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY06_03060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY06_03065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY06_03075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY06_03080	COG0024	Methionine aminopeptidase
HPY06_03085	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY06_03090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY06_03095	COG0528	UMP kinase activity
HPY06_03100	COG0233	cytoplasmic translational termination
HPY06_03105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY06_03110	COG0575	Belongs to the CDS family
HPY06_03115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY06_03120	COG0750	zinc metalloprotease
HPY06_03130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY06_03135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_03140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY06_03145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_03150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_03155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY06_03160	COG0587	DNA-directed DNA polymerase activity
HPY06_03165	COG0825	malonyl-CoA metabolic process
HPY06_03175	COG0037	tRNA processing
HPY06_03185	COG3479	Phenolic acid decarboxylase
HPY06_03190	COG0347	Belongs to the P(II) protein family
HPY06_03195	COG3021	interspecies interaction between organisms
HPY06_03200	COG1388	LysM domain
HPY06_03200	COG0741	lytic transglycosylase activity
HPY06_03205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY06_03210	COG2226	methyltransferase
HPY06_03215	COG0328	RNA-DNA hybrid ribonuclease activity
HPY06_03230	COG1960	acyl-CoA dehydrogenase activity
HPY06_03235	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY06_03240	COG0121	glutamine amidotransferase
HPY06_03245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY06_03250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY06_03255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY06_03260	COG3706	GGDEF domain
HPY06_03265	COG1187	pseudouridine synthase activity
HPY06_03270	COG2840	Smr protein MutS2
HPY06_03300	COG2608	mercury ion transmembrane transporter activity
HPY06_03300	COG2217	Heavy metal translocating P-type atpase
HPY06_03305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY06_03320	COG1629	transport
HPY06_03320	COG4774	siderophore transport
HPY06_03325	COG2375	cellular response to nickel ion
HPY06_03330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY06_03330	COG2226	methyltransferase
HPY06_03330	COG3433	isochorismatase activity
HPY06_03365	COG0784	Response regulator, receiver
HPY06_03365	COG0835	chemotaxis
HPY06_03370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY06_03375	COG1815	bacterial-type flagellum-dependent cell motility
HPY06_03390	COG1749	Flagellar hook protein flgE
HPY06_03395	COG4787	bacterial-type flagellum-dependent cell motility
HPY06_03405	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY06_03410	COG1706	bacterial-type flagellum-dependent cell motility
HPY06_03415	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY06_03415	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY06_03430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_03435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_03520	COG0012	GTP binding
HPY06_03525	COG0193	aminoacyl-tRNA hydrolase activity
HPY06_03530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY06_03535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY06_03540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY06_03545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY06_03550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY06_03555	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY06_03565	COG2912	Transglutaminase-like superfamily
HPY06_03570	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY06_03575	COG0737	Belongs to the 5'-nucleotidase family
HPY06_03580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY06_03585	COG2233	PERMEase
HPY06_03605	COG1393	Belongs to the ArsC family
HPY06_03610	COG4783	chaperone-mediated protein folding
HPY06_03630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY06_03645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY06_03660	COG1876	peptidase activity
HPY06_03670	COG1393	Belongs to the ArsC family
HPY06_03690	COG2837	iron assimilation
HPY06_03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_03700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_03705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_03710	COG1334	flagellar protein FlaG
HPY06_03715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY06_03725	COG1516	flagellar protein fliS
HPY06_03735	COG4191	Histidine kinase
HPY06_03745	COG1677	Flagellar hook-basal body complex protein FliE
HPY06_03755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY06_03785	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY06_03810	COG1987	bacterial-type flagellum assembly
HPY06_03815	COG1684	flagellar biosynthetic protein fliR
HPY06_03825	COG2840	Smr protein MutS2
HPY06_03830	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY06_03835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY06_03840	COG2860	membrane
HPY06_03845	COG3101	peptidyl-lysine hydroxylation
HPY06_03855	COG0431	NADPH-dependent FMN reductase
HPY06_03860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY06_03860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY06_03865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY06_03870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY06_03875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY06_03880	COG0735	belongs to the Fur family
HPY06_03890	COG0583	DNA-binding transcription factor activity
HPY06_03900	COG1346	cytolysis
HPY06_03915	COG0596	Alpha beta hydrolase
HPY06_03920	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY06_03925	COG0033	Phosphoglucomutase
HPY06_03935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY06_03940	COG0372	Belongs to the citrate synthase family
HPY06_03945	COG2009	succinate dehydrogenase
HPY06_03950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY06_03955	COG1053	succinate dehydrogenase
HPY06_03965	COG0567	Dehydrogenase, E1 component
HPY06_03970	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY06_03975	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY06_03985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY06_03990	COG1121	(ABC) transporter
HPY06_03995	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY06_04000	COG4977	sequence-specific DNA binding
HPY06_04005	COG1918	ferrous iron import across plasma membrane
HPY06_04025	COG0018	arginyl-trna synthetase
HPY06_04035	COG1025	Belongs to the peptidase M16 family
HPY06_04040	COG2062	phosphohistidine phosphatase, SixA
HPY06_04070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY06_04075	COG2198	Histidine kinase
HPY06_04075	COG0643	Histidine kinase
HPY06_04075	COG0784	Response regulator, receiver
HPY06_04080	COG2201	protein-glutamate methylesterase activity
HPY06_04085	COG1192	Involved in chromosome partitioning
HPY06_04095	COG0835	chemotaxis
HPY06_04105	COG4133	protoheme IX ABC transporter activity
HPY06_04110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY06_04115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY06_04125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY06_04130	COG1138	Cytochrome C-type biogenesis protein
HPY06_04135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY06_04140	COG4235	cytochrome complex assembly
HPY06_04140	COG3088	subunit of a heme lyase
HPY06_04150	COG2853	Lipoprotein
HPY06_04170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY06_04175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY06_04180	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY06_04195	COG3083	sulfuric ester hydrolase activity
HPY06_04200	COG3082	Protein of unknown function (DUF1414)
HPY06_04205	COG3081	Nucleoid-associated protein
HPY06_04215	COG1757	Na H antiporter
HPY06_04220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY06_04225	COG2095	MarC family integral membrane protein
HPY06_04230	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_04230	COG1454	alcohol dehydrogenase
HPY06_04240	COG0659	secondary active sulfate transmembrane transporter activity
HPY06_04245	COG1530	ribonuclease E activity
HPY06_04250	COG0564	pseudouridine synthase activity
HPY06_04255	COG0424	maF-like protein
HPY06_04260	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY06_04265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY06_04270	COG0416	fatty acid biosynthetic process
HPY06_04275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY06_04285	COG1028	Short-chain dehydrogenase reductase Sdr
HPY06_04290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY06_04295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY06_04300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY06_04305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY06_04310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY06_04320	COG0084	hydrolase, TatD family'
HPY06_04325	COG1263	PTS System
HPY06_04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_04335	COG0733	neurotransmitter:sodium symporter activity
HPY06_04350	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY06_04360	COG1940	carbohydrate kinase activity
HPY06_04365	COG0784	Response regulator, receiver
HPY06_04365	COG0835	chemotaxis
HPY06_04380	COG2226	methyltransferase
HPY06_04390	COG0676	glucose-6-phosphate 1-epimerase activity
HPY06_04395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY06_04400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_04410	COG3139	Protein of unknown function (DUF1315)
HPY06_04415	COG0252	asparaginase activity
HPY06_04420	COG0616	signal peptide processing
HPY06_04425	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY06_04425	COG1902	pentaerythritol trinitrate reductase activity
HPY06_04430	COG0788	formyltetrahydrofolate deformylase activity
HPY06_04440	COG1199	ATP-dependent helicase activity
HPY06_04445	COG1214	PFAM Peptidase M22, glycoprotease
HPY06_04460	COG0596	Alpha beta hydrolase
HPY06_04465	COG0318	PFAM AMP-dependent synthetase and ligase
HPY06_04470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY06_04475	COG0705	Rhomboid family
HPY06_04485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY06_04490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY06_04495	COG0436	Aminotransferase
HPY06_04500	COG1169	isochorismate synthase
HPY06_04505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY06_04510	COG0596	Alpha beta hydrolase
HPY06_04530	COG3135	benzoate transporter
HPY06_04555	COG3015	lipoprotein NlpE involved in copper resistance
HPY06_04560	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY06_04565	COG2894	cell division
HPY06_04570	COG0850	regulation of cytokinetic process
HPY06_04575	COG3100	YcgL domain-containing protein
HPY06_04580	COG2951	lytic endotransglycosylase activity
HPY06_04590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY06_04595	COG3005	denitrification pathway
HPY06_04600	COG0243	molybdopterin cofactor binding
HPY06_04615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_04630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY06_04665	COG4589	Belongs to the CDS family
HPY06_04675	COG5001	Diguanylate cyclase
HPY06_04675	COG3300	MHYT domain
HPY06_04685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY06_04690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY06_04695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY06_04700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY06_04710	COG4191	Histidine kinase
HPY06_04720	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY06_04730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY06_04735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY06_04740	COG0776	regulation of translation
HPY06_04745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY06_04750	COG1555	photosystem II stabilization
HPY06_04755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY06_04760	COG0539	negative regulation of cytoplasmic translation
HPY06_04765	COG0776	regulation of translation
HPY06_04770	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY06_04775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY06_04795	COG0583	DNA-binding transcription factor activity
HPY06_04805	COG0686	Belongs to the AlaDH PNT family
HPY06_04815	COG1674	ftsk spoiiie
HPY06_04820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY06_04825	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY06_04830	COG2186	Transcriptional regulator
HPY06_04845	COG0537	adenosine 5'-monophosphoramidase activity
HPY06_04870	COG3150	esterase
HPY06_04875	COG1252	NADH dehydrogenase
HPY06_04900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY06_04910	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY06_04915	COG1136	(ABC) transporter
HPY06_04920	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY06_04930	COG0658	competence protein
HPY06_04930	COG2333	competence protein COMEC
HPY06_04935	COG1132	(ABC) transporter
HPY06_04940	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY06_04945	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY06_04950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY06_04955	COG2719	SpoVR family
HPY06_04960	COG2718	Belongs to the UPF0229 family
HPY06_04965	COG2766	serine protein kinase
HPY06_04970	COG3013	Belongs to the UPF0304 family
HPY06_04980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY06_04985	COG0840	transmembrane signaling receptor activity
HPY06_04995	COG1882	Formate acetyltransferase
HPY06_05020	COG4160	amino acid transport
HPY06_05025	COG0708	Exodeoxyribonuclease III
HPY06_05035	COG3923	Primosomal replication protein n
HPY06_05040	COG0730	response to heat
HPY06_05045	COG1199	ATP-dependent helicase activity
HPY06_05055	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY06_05060	COG3012	SEC-C Motif Domain Protein
HPY06_05065	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY06_05070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_05075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY06_05080	COG0215	cysteine-tRNA ligase activity
HPY06_05085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY06_05090	COG0632	four-way junction helicase activity
HPY06_05100	COG1271	oxidase subunit
HPY06_05105	COG1294	oxidase, subunit
HPY06_05110	COG4890	Cyd operon protein YbgT
HPY06_05115	COG3790	cyd operon protein YbgE
HPY06_05120	COG0824	Thioesterase
HPY06_05125	COG0811	peptide transport
HPY06_05140	COG0823	Involved in the tonB-independent uptake of proteins
HPY06_05145	COG2885	chlorophyll binding
HPY06_05155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY06_05165	COG5002	protein histidine kinase activity
HPY06_05165	COG0784	Response regulator, receiver
HPY06_05175	COG1482	cell wall glycoprotein biosynthetic process
HPY06_05180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_05180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_05180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_05185	COG2207	Transcriptional regulator
HPY06_05195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_05205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_05215	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_05220	COG3284	Transcriptional regulator
HPY06_05225	COG4628	conserved protein (DUF2132)
HPY06_05235	COG0415	Belongs to the DNA photolyase family
HPY06_05260	COG4409	exo-alpha-(2->6)-sialidase activity
HPY06_05265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY06_05270	COG1940	carbohydrate kinase activity
HPY06_05280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY06_05285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY06_05290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY06_05295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPY06_05300	COG1737	Transcriptional regulator
HPY06_05305	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY06_05310	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY06_05320	COG5492	domain, Protein
HPY06_05320	COG4932	domain protein
HPY06_05345	COG0596	Alpha beta hydrolase
HPY06_05355	COG3064	Membrane
HPY06_05460	COG4789	Type iii secretion
HPY06_05465	COG4792	protein secretion
HPY06_05495	COG3710	Transcriptional regulator
HPY06_05505	COG4790	Type iii secretion
HPY06_05585	COG0582	viral genome integration into host DNA
HPY06_05595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY06_05600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_05610	COG3008	intermembrane lipid transfer
HPY06_05610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY06_05615	COG2995	paraquat-inducible protein a
HPY06_05620	COG1309	transcriptional regulator
HPY06_05625	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_05645	COG1960	acyl-CoA dehydrogenase activity
HPY06_05650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY06_05655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY06_05660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY06_05665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY06_05680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY06_05685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY06_05690	COG0297	glycogen (starch) synthase activity
HPY06_05710	COG3070	regulator of competence-specific genes
HPY06_05715	COG1609	Transcriptional regulator
HPY06_05720	COG3381	protein complex oligomerization
HPY06_05725	COG0745	RESPONSE REGULATOR receiver
HPY06_05730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY06_05735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY06_05740	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY06_05745	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY06_05760	COG1280	lysine exporter protein (LysE YggA)
HPY06_05765	COG1032	radical SAM domain protein
HPY06_05770	COG5001	Diguanylate cyclase
HPY06_05775	COG0612	Peptidase, M16
HPY06_05790	COG0583	DNA-binding transcription factor activity
HPY06_05795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY06_05805	COG2350	Protein conserved in bacteria
HPY06_05810	COG1607	acyl-coa hydrolase
HPY06_05825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY06_05830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY06_05840	COG2116	formate transmembrane transporter activity
HPY06_05845	COG4459	periplasmic nitrate reductase
HPY06_05850	COG3005	denitrification pathway
HPY06_05855	COG0243	molybdopterin cofactor binding
HPY06_05875	COG1227	inorganic diphosphatase activity
HPY06_05895	COG4172	Belongs to the ABC transporter superfamily
HPY06_05910	COG4168	peptide transport system, permease
HPY06_05920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY06_05925	COG1842	Phage shock protein A
HPY06_05940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_05955	COG2818	Glycosylase
HPY06_05960	COG0589	response to stress
HPY06_05970	COG0626	cystathionine gamma-synthase activity
HPY06_05980	COG0733	neurotransmitter:sodium symporter activity
HPY06_05985	COG0564	pseudouridine synthase activity
HPY06_05990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY06_05995	COG4136	ATPase activity
HPY06_06000	COG4135	transport system, permease component
HPY06_06005	COG4134	Bacterial extracellular solute-binding protein
HPY06_06015	COG3313	Fe-S protein
HPY06_06025	COG0814	amino acid
HPY06_06035	COG2239	Acts as a magnesium transporter
HPY06_06040	COG2205	protein histidine kinase activity
HPY06_06040	COG0784	Response regulator, receiver
HPY06_06055	COG4934	collagen metabolic process
HPY06_06090	COG0840	transmembrane signaling receptor activity
HPY06_06100	COG2203	Gaf domain
HPY06_06100	COG5001	Diguanylate cyclase
HPY06_06100	COG4251	negative regulation of phosphorylation
HPY06_06100	COG3706	GGDEF domain
HPY06_06105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY06_06110	COG5002	protein histidine kinase activity
HPY06_06125	COG1061	Type III restriction enzyme res subunit
HPY06_06130	COG1187	pseudouridine synthase activity
HPY06_06135	COG2814	Major facilitator Superfamily
HPY06_06145	COG0702	epimerase
HPY06_06150	COG0534	Mate efflux family protein
HPY06_06155	COG4181	ATPase activity
HPY06_06170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY06_06180	COG1748	Saccharopine dehydrogenase
HPY06_06195	COG1538	Outer membrane efflux protein
HPY06_06215	COG0583	DNA-binding transcription factor activity
HPY06_06225	COG1451	nucleotide metabolic process
HPY06_06240	COG3063	Type IV pilus biogenesis stability protein PilW
HPY06_06245	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY06_06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_06280	COG3290	protein histidine kinase activity
HPY06_06285	COG4565	transcriptional regulatory protein
HPY06_06295	COG0784	Response regulator, receiver
HPY06_06295	COG0835	chemotaxis
HPY06_06345	COG1085	galactose-1-phosphate uridylyltransferase
HPY06_06350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY06_06355	COG2017	converts alpha-aldose to the beta-anomer
HPY06_06370	COG3527	Alpha-acetolactate decarboxylase
HPY06_06380	COG3064	Membrane
HPY06_06390	COG0753	catalase activity
HPY06_06410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY06_06460	COG1271	oxidase subunit
HPY06_06465	COG1294	oxidase, subunit
HPY06_06470	COG1136	(ABC) transporter
HPY06_06470	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY06_06475	COG1136	(ABC) transporter
HPY06_06475	COG0577	efflux transmembrane transporter activity
HPY06_06480	COG0577	efflux transmembrane transporter activity
HPY06_06535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY06_06550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY06_06560	COG2723	6-phospho-beta-galactosidase activity
HPY06_06565	COG1609	Transcriptional regulator
HPY06_06570	COG0251	oxidation-reduction process
HPY06_06575	COG2731	YhcH YjgK YiaL family protein
HPY06_06580	COG0584	glycerophosphoryl diester phosphodiesterase
HPY06_06585	COG1349	DNA-binding transcription factor activity
HPY06_06590	COG3842	ATPase activity
HPY06_06595	COG0395	ABC-type sugar transport system, permease component
HPY06_06600	COG1175	transmembrane transport
HPY06_06615	COG0811	peptide transport
HPY06_06620	COG0811	peptide transport
HPY06_06625	COG0848	biopolymer transport protein
HPY06_06630	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY06_06640	COG1793	dna ligase
HPY06_06650	COG0534	Mate efflux family protein
HPY06_06660	COG3001	Fructosamine kinase
HPY06_06670	COG0791	NLP P60 protein
HPY06_06675	COG0840	transmembrane signaling receptor activity
HPY06_06690	COG1940	carbohydrate kinase activity
HPY06_06705	COG0746	molybdenum cofactor guanylyltransferase activity
HPY06_06710	COG3842	ATPase activity
HPY06_06715	COG4662	Binding-protein-dependent transport system inner membrane component
HPY06_06725	COG2204	response regulator
HPY06_06730	COG3852	Histidine kinase
HPY06_06735	COG0488	(ABC) transporter
HPY06_06740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY06_06770	COG3383	formate dehydrogenase (NAD+) activity
HPY06_06770	COG0243	molybdopterin cofactor binding
HPY06_06775	COG0437	4 iron, 4 sulfur cluster binding
HPY06_06790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY06_06795	COG1666	GTP binding
HPY06_06800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY06_06815	COG2996	Protein conserved in bacteria
HPY06_06825	COG3008	intermembrane lipid transfer
HPY06_06830	COG2995	paraquat-inducible protein a
HPY06_06835	COG1132	(ABC) transporter
HPY06_06840	COG1956	GAF domain-containing protein
HPY06_06845	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY06_06860	COG0308	aminopeptidase N
HPY06_06875	COG0167	dihydroorotate dehydrogenase activity
HPY06_06885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY06_06885	COG0116	Belongs to the methyltransferase superfamily
HPY06_06910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY06_06915	COG1067	ATP-dependent peptidase activity
HPY06_06920	COG3120	sequence-specific DNA binding
HPY06_06995	COG3064	Membrane
HPY06_06995	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY06_06995	COG1073	alpha beta
HPY06_07000	COG2994	toxin metabolic process
HPY06_07025	COG2205	protein histidine kinase activity
HPY06_07025	COG0784	Response regulator, receiver
HPY06_07040	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY06_07055	COG2010	Cytochrome c
HPY06_07065	COG2217	Heavy metal translocating P-type atpase
HPY06_07080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY06_07085	COG0589	response to stress
HPY06_07090	COG0037	tRNA processing
HPY06_07110	COG3842	ATPase activity
HPY06_07120	COG1177	transmembrane transport
HPY06_07130	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY06_07145	COG1115	amino acid carrier protein
HPY06_07150	COG1280	lysine exporter protein (LysE YggA)
HPY06_07185	COG3501	Rhs element vgr protein
HPY06_07195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY06_07215	COG0513	Belongs to the DEAD box helicase family
HPY06_07220	COG2076	Multidrug Resistance protein
HPY06_07225	COG0477	Major facilitator Superfamily
HPY06_07230	COG0583	DNA-binding transcription factor activity
HPY06_07240	COG0402	S-adenosylhomocysteine deaminase activity
HPY06_07245	COG0095	Lipoate-protein ligase
HPY06_07250	COG0443	Heat shock 70 kDa protein
HPY06_07260	COG1643	Atp-dependent helicase
HPY06_07290	COG0443	Heat shock 70 kDa protein
HPY06_07295	COG0443	Heat shock 70 kDa protein
HPY06_07300	COG3706	GGDEF domain
HPY06_07330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY06_07335	COG0602	queuosine metabolic process
HPY06_07340	COG0561	phosphatase activity
HPY06_07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_07355	COG4597	amino acid ABC transporter
HPY06_07360	COG0765	amino acid transport
HPY06_07365	COG1126	abc transporter atp-binding protein
HPY06_07370	COG0670	Belongs to the BI1 family
HPY06_07375	COG2920	part of a sulfur-relay system
HPY06_07380	COG1254	Belongs to the acylphosphatase family
HPY06_07385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY06_07390	COG3706	GGDEF domain
HPY06_07405	COG3437	response regulator, receiver
HPY06_07410	COG0625	glutathione transferase activity
HPY06_07420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY06_07430	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY06_07460	COG0372	Belongs to the citrate synthase family
HPY06_07465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY06_07505	COG1566	PFAM secretion protein HlyD family protein
HPY06_07525	COG1129	ABC transporter
HPY06_07550	COG0745	RESPONSE REGULATOR receiver
HPY06_07555	COG5002	protein histidine kinase activity
HPY06_07560	COG3713	MltA-interacting MipA family protein
HPY06_07565	COG2990	Protein conserved in bacteria
HPY06_07575	COG4191	Histidine kinase
HPY06_07575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_07580	COG0471	metal ion transport
HPY06_07590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY06_07605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_07615	COG3768	UPF0283 membrane protein
HPY06_07620	COG3106	COG3106 Predicted ATPase
HPY06_07635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY06_07640	COG0494	nUDIX hydrolase
HPY06_07645	COG0814	amino acid
HPY06_07650	COG1760	l-serine dehydratase
HPY06_07655	COG0720	synthase
HPY06_07660	COG0840	transmembrane signaling receptor activity
HPY06_07665	COG0017	Asparaginyl-tRNA synthetase
HPY06_07670	COG0351	phosphomethylpyrimidine kinase
HPY06_07675	COG3437	response regulator, receiver
HPY06_07675	COG2770	Histidine kinase
HPY06_07680	COG1448	Aminotransferase
HPY06_07695	COG0840	transmembrane signaling receptor activity
HPY06_07700	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY06_07705	COG2943	transferase activity, transferring hexosyl groups
HPY06_07710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY06_07715	COG1846	Transcriptional regulator
HPY06_07740	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY06_07755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY06_07760	COG3108	Peptidase M15
HPY06_07790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY06_07800	COG2814	Major facilitator Superfamily
HPY06_07820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY06_07825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY06_07830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY06_07860	COG0840	transmembrane signaling receptor activity
HPY06_07875	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY06_07880	COG4139	cobalamin transport
HPY06_07885	COG2988	succinylglutamate desuccinylase activity
HPY06_07900	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY06_07905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY06_07910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_07920	COG2925	Exonuclease
HPY06_07925	COG1380	Effector of murein hydrolase LrgA
HPY06_07930	COG1346	cytolysis
HPY06_07960	COG0776	regulation of translation
HPY06_07965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_07965	COG0072	phenylalanine-tRNA ligase activity
HPY06_07970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY06_08010	COG0322	excinuclease ABC activity
HPY06_08015	COG2197	response regulator
HPY06_08020	COG0417	DNA replication proofreading
HPY06_08025	COG5001	Diguanylate cyclase
HPY06_08035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY06_08040	COG3099	Belongs to the UPF0263 family
HPY06_08055	COG1228	amidohydrolase
HPY06_08060	COG0010	Belongs to the arginase family
HPY06_08065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY06_08070	COG2986	histidine ammonia-lyase
HPY06_08090	COG0247	lactate metabolic process
HPY06_08090	COG0277	FAD linked oxidase domain protein
HPY06_08105	COG2885	chlorophyll binding
HPY06_08125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY06_08135	COG0281	malic enzyme
HPY06_08145	COG2949	membrane
HPY06_08150	COG3706	GGDEF domain
HPY06_08155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY06_08165	COG0492	ferredoxin-NADP+ reductase activity
HPY06_08170	COG4988	ABC transporter
HPY06_08175	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY06_08180	COG1187	pseudouridine synthase activity
HPY06_08185	COG0009	L-threonylcarbamoyladenylate synthase
HPY06_08190	COG0613	PHP domain protein
HPY06_08200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY06_08205	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY06_08210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY06_08215	COG0135	phosphoribosylanthranilate isomerase activity
HPY06_08215	COG0134	indole-3-glycerol-phosphate synthase activity
HPY06_08220	COG0133	tryptophan synthase activity
HPY06_08225	COG0159	tryptophan synthase activity
HPY06_08235	COG1435	thymidine kinase activity
HPY06_08240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY06_08245	COG1801	Protein of unknown function DUF72
HPY06_08250	COG4106	trans-aconitate 2-methyltransferase activity
HPY06_08255	COG0500	methyltransferase
HPY06_08260	COG0189	ligase activity
HPY06_08260	COG4067	protein conserved in archaea
HPY06_08275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY06_08285	COG3852	Histidine kinase
HPY06_08300	COG3070	regulator of competence-specific genes
HPY06_08310	COG2431	L-lysine efflux transmembrane transporter activity
HPY06_08320	COG0076	glutamate decarboxylase activity
HPY06_08325	COG1737	Transcriptional regulator
HPY06_08330	COG1454	alcohol dehydrogenase
HPY06_08330	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_08335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY06_08340	COG2985	domain, Protein
HPY06_08340	COG3273	potassium ion transport
HPY06_08345	COG0542	response to heat
HPY06_08350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY06_08355	COG1278	Cold shock
HPY06_08365	COG1187	pseudouridine synthase activity
HPY06_08370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY06_08370	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY06_08375	COG0107	imidazoleglycerol-phosphate synthase activity
HPY06_08380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY06_08385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY06_08390	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY06_08390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY06_08395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY06_08400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY06_08405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY06_08410	COG1757	Na H antiporter
HPY06_08415	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY06_08420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_08425	COG0482	sulfurtransferase activity
HPY06_08430	COG2915	High frequency lysogenization protein hflD homolog
HPY06_08435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY06_08445	COG2268	Band 7 protein
HPY06_08455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY06_08470	COG0300	oxidoreductase activity
HPY06_08480	COG0501	Belongs to the peptidase M48B family
HPY06_08490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY06_08495	COG2226	methyltransferase
HPY06_08500	COG0156	8-amino-7-oxononanoate synthase activity
HPY06_08505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY06_08510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY06_08515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY06_08520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY06_08525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY06_08535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY06_08540	COG2203	Gaf domain
HPY06_08540	COG2199	diguanylate cyclase activity
HPY06_08550	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY06_08560	COG4628	conserved protein (DUF2132)
HPY06_08565	COG3092	negative regulation of chromosome organization
HPY06_08570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY06_08575	COG0857	belongs to the CobB CobQ family
HPY06_08575	COG0280	phosphate acetyltransferase
HPY06_08580	COG0435	Glutathione S-transferase
HPY06_08585	COG4608	Belongs to the ABC transporter superfamily
HPY06_08590	COG0444	Belongs to the ABC transporter superfamily
HPY06_08595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_08600	COG0601	transmembrane transport
HPY06_08620	COG2204	response regulator
HPY06_08625	COG3300	MHYT domain
HPY06_08625	COG5001	Diguanylate cyclase
HPY06_08630	COG4191	Histidine kinase
HPY06_08635	COG5002	protein histidine kinase activity
HPY06_08645	COG2201	protein-glutamate methylesterase activity
HPY06_08660	COG0009	L-threonylcarbamoyladenylate synthase
HPY06_08675	COG1881	PFAM PEBP family protein
HPY06_08700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY06_08705	COG0640	Transcriptional regulator
HPY06_08715	COG3706	GGDEF domain
HPY06_08735	COG1946	Acyl-CoA thioesterase
HPY06_08740	COG1522	sequence-specific DNA binding
HPY06_08750	COG0616	signal peptide processing
HPY06_08755	COG1028	Short-chain dehydrogenase reductase Sdr
HPY06_08760	COG2983	Belongs to the UPF0260 family
HPY06_08770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY06_08775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY06_08785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY06_08790	COG2832	Protein of unknown function (DUF454)
HPY06_08795	COG0745	RESPONSE REGULATOR receiver
HPY06_08800	COG0583	DNA-binding transcription factor activity
HPY06_08805	COG0778	Nitroreductase
HPY06_08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY06_08810	COG1024	Enoyl-CoA hydratase
HPY06_08815	COG0183	Belongs to the thiolase family
HPY06_08830	COG2067	long-chain fatty acid transport protein
HPY06_08840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY06_08845	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY06_08850	COG2982	Protein involved in outer membrane biogenesis
HPY06_08855	COG0572	uridine kinase
HPY06_08860	COG0489	protein tyrosine kinase activity
HPY06_08865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_08865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_08875	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY06_08885	COG0617	tRNA 3'-terminal CCA addition
HPY06_08885	COG0517	IMP dehydrogenase activity
HPY06_08885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY06_08890	COG2199	diguanylate cyclase activity
HPY06_08895	COG0314	molybdopterin synthase activity
HPY06_08900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY06_08905	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY06_08910	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY06_08915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY06_08920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY06_08925	COG2198	Histidine kinase
HPY06_08930	COG2204	response regulator
HPY06_08935	COG0556	nucleotide-excision repair
HPY06_08945	COG4657	Part of a membrane complex involved in electron transport
HPY06_08950	COG2878	Part of a membrane complex involved in electron transport
HPY06_08955	COG4656	Part of a membrane complex involved in electron transport
HPY06_08970	COG4660	Part of a membrane complex involved in electron transport
HPY06_08975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY06_08980	COG0346	lactoylglutathione lyase activity
HPY06_08995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY06_09000	COG2056	Na+-H+ antiporter family
HPY06_09005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY06_09010	COG1286	toxin biosynthetic process
HPY06_09015	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY06_09020	COG0285	dihydrofolate synthase activity
HPY06_09025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY06_09030	COG0101	tRNA pseudouridine synthase activity
HPY06_09045	COG2190	(PTS) system
HPY06_09045	COG1263	PTS System
HPY06_09045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_09050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY06_09055	COG1846	Transcriptional regulator
HPY06_09055	COG1940	carbohydrate kinase activity
HPY06_09060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY06_09060	COG4651	solute:proton antiporter activity
HPY06_09065	COG0367	asparagine synthase
HPY06_09080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY06_09085	COG0563	adenylate kinase activity
HPY06_09090	COG0326	Molecular chaperone. Has ATPase activity
HPY06_09095	COG3710	Transcriptional regulator
HPY06_09110	COG0622	Phosphoesterase
HPY06_09115	COG1090	epimerase
HPY06_09120	COG0300	oxidoreductase activity
HPY06_09125	COG3118	belongs to the thioredoxin family
HPY06_09130	COG0330	HflC and HflK could
HPY06_09135	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY06_09140	COG0789	Transcriptional regulator
HPY06_09155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY06_09160	COG3115	cell septum assembly
HPY06_09165	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY06_09170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY06_09175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_09185	COG2190	(PTS) system
HPY06_09190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_09195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY06_09200	COG1702	phosphate starvation-inducible protein PhoH
HPY06_09205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY06_09210	COG4535	Mg2 and Co2 transporter CorC
HPY06_09215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY06_09220	COG2888	peptidyl-tyrosine sulfation
HPY06_09225	COG0495	leucyl-tRNA aminoacylation
HPY06_09230	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY06_09235	COG1466	dna polymerase III delta subunit
HPY06_09240	COG0799	negative regulation of ribosome biogenesis
HPY06_09245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY06_09250	COG0768	penicillin binding
HPY06_09255	COG0772	Belongs to the SEDS family
HPY06_09260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY06_09265	COG1686	Belongs to the peptidase S11 family
HPY06_09270	COG2921	Belongs to the UPF0250 family
HPY06_09275	COG0321	lipoyl(octanoyl) transferase activity
HPY06_09280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY06_09290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY06_09315	COG1596	polysaccharide export
HPY06_09325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY06_09355	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY06_09365	COG0438	transferase activity, transferring glycosyl groups
HPY06_09375	COG1045	serine acetyltransferase
HPY06_09395	COG0110	maltose O-acetyltransferase activity
HPY06_09400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY06_09405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY06_09410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY06_09415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY06_09445	COG0366	Alpha amylase catalytic
HPY06_09450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_09450	COG1263	PTS System
HPY06_09455	COG1609	Transcriptional regulator
HPY06_09460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY06_09465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY06_09470	COG2011	ABC-type metal ion transport system permease component
HPY06_09475	COG1464	Belongs to the NlpA lipoprotein family
HPY06_09480	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY06_09490	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY06_09490	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY06_09500	COG3706	GGDEF domain
HPY06_09505	COG1611	Belongs to the LOG family
HPY06_09510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY06_09515	COG2363	Small membrane protein
HPY06_09520	COG0583	DNA-binding transcription factor activity
HPY06_09525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY06_09525	COG0301	tRNA thio-modification
HPY06_09535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY06_09540	COG1722	exodeoxyribonuclease VII activity
HPY06_09545	COG0142	geranyltranstransferase activity
HPY06_09550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY06_09555	COG0564	pseudouridine synthase activity
HPY06_09560	COG3098	single-species biofilm formation
HPY06_09575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_09585	COG1671	Belongs to the UPF0178 family
HPY06_09590	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY06_09595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY06_09600	COG0254	rRNA binding
HPY06_09605	COG1720	tRNA m6t6A37 methyltransferase activity
HPY06_09610	COG0442	prolyl-tRNA aminoacylation
HPY06_09630	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY06_09630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY06_09640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY06_09650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY06_09680	COG0484	heat shock protein binding
HPY06_09685	COG0443	Heat shock 70 kDa protein
HPY06_09690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY06_09695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY06_09700	COG0497	DNA recombination
HPY06_09705	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_09710	COG2914	Belongs to the UPF0125 (RnfH) family
HPY06_09715	COG2867	negative regulation of translational initiation
HPY06_09720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY06_09750	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPY06_09770	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY06_09775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY06_09780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY06_09800	COG3051	citrate lyase alpha subunit
HPY06_09805	COG2301	Belongs to the HpcH HpaI aldolase family
HPY06_09815	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY06_09825	COG3630	sodium ion export across plasma membrane
HPY06_09830	COG0511	ligase activity, forming carbon-carbon bonds
HPY06_09830	COG5016	pyruvate
HPY06_09835	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY06_09845	COG4565	transcriptional regulatory protein
HPY06_09870	COG1115	amino acid carrier protein
HPY06_09875	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY06_09880	COG0583	DNA-binding transcription factor activity
HPY06_09890	COG1120	ATPase activity
HPY06_09895	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_09900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_09905	COG4592	Periplasmic binding protein
HPY06_09915	COG1028	Short-chain dehydrogenase reductase Sdr
HPY06_09920	COG1169	isochorismate synthase
HPY06_09925	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY06_09930	COG3433	isochorismatase activity
HPY06_09930	COG1535	isochorismatase
HPY06_09935	COG1584	GPR1 FUN34 yaaH family protein
HPY06_09945	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY06_09955	COG0519	Catalyzes the synthesis of GMP from XMP
HPY06_09955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY06_09960	COG0517	IMP dehydrogenase activity
HPY06_09960	COG0516	GMP reductase activity
HPY06_09965	COG1570	exodeoxyribonuclease VII activity
HPY06_09980	COG1160	GTP binding
HPY06_09985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_09990	COG2976	Protein conserved in bacteria
HPY06_09995	COG0124	histidyl-tRNA synthetase
HPY06_10000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY06_10005	COG1426	Protein conserved in bacteria
HPY06_10015	COG0105	UTP biosynthetic process
HPY06_10020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY06_10025	COG2975	iron-sulfur cluster assembly
HPY06_10030	COG0633	Ferredoxin
HPY06_10050	COG0822	iron-sulfur transferase activity
HPY06_10055	COG1104	cysteine desulfurase activity
HPY06_10060	COG1959	2 iron, 2 sulfur cluster binding
HPY06_10070	COG0483	inositol monophosphate 1-phosphatase activity
HPY06_10075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_10080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_10085	COG1862	Preprotein translocase
HPY06_10095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY06_10100	COG0517	IMP dehydrogenase activity
HPY06_10110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY06_10115	COG0583	DNA-binding transcription factor activity
HPY06_10120	COG0450	alkyl hydroperoxide reductase
HPY06_10125	COG3142	Participates in the control of copper homeostasis
HPY06_10140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY06_10145	COG0581	inorganic phosphate transmembrane transporter activity
HPY06_10155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY06_10160	COG0248	Ppx GppA phosphatase
HPY06_10170	COG5002	protein histidine kinase activity
HPY06_10175	COG0745	RESPONSE REGULATOR receiver
HPY06_10190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY06_10235	COG0542	response to heat
HPY06_10245	COG0564	pseudouridine synthase activity
HPY06_10250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_10255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY06_10260	COG1605	Chorismate mutase
HPY06_10260	COG0077	Prephenate dehydratase
HPY06_10265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY06_10270	COG5001	Diguanylate cyclase
HPY06_10280	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY06_10290	COG0488	(ABC) transporter
HPY06_10300	COG1605	Chorismate mutase
HPY06_10300	COG0287	Prephenate dehydrogenase
HPY06_10305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY06_10310	COG3275	phosphorelay sensor kinase activity
HPY06_10315	COG3279	Response regulator of the LytR AlgR family
HPY06_10325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY06_10330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY06_10345	COG1966	Carbon starvation protein
HPY06_10350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY06_10355	COG1047	Peptidyl-prolyl cis-trans
HPY06_10360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY06_10370	COG0196	riboflavin kinase activity
HPY06_10375	COG0728	peptidoglycan biosynthetic process
HPY06_10380	COG0268	Binds directly to 16S ribosomal RNA
HPY06_10385	COG0640	Transcriptional regulator
HPY06_10390	COG0583	DNA-binding transcription factor activity
HPY06_10395	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY06_10400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPY06_10405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY06_10410	COG0730	response to heat
HPY06_10415	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY06_10420	COG0494	nUDIX hydrolase
HPY06_10425	COG3066	DNA modification
HPY06_10430	COG0667	Aldo Keto reductase
HPY06_10440	COG2204	response regulator
HPY06_10445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY06_10465	COG0513	Belongs to the DEAD box helicase family
HPY06_10490	COG3153	acetyltransferase
HPY06_10495	COG3154	lipid carrier protein
HPY06_10505	COG0826	peptidase U32
HPY06_10510	COG0826	peptidase U32
HPY06_10540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY06_10550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY06_10555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY06_10560	COG0195	Participates in both transcription termination and antitermination
HPY06_10565	COG0779	Required for maturation of 30S ribosomal subunits
HPY06_10580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY06_10590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY06_10595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY06_10600	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY06_10605	COG1534	Rna-binding protein
HPY06_10610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY06_10615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY06_10620	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY06_10625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY06_10630	COG0739	heme binding
HPY06_10645	COG0316	Belongs to the HesB IscA family
HPY06_10650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY06_10655	COG0628	permease
HPY06_10660	COG2813	Specifically methylates the guanine in position
HPY06_10665	COG0784	Response regulator, receiver
HPY06_10665	COG2205	protein histidine kinase activity
HPY06_10670	COG0747	negative chemotaxis
HPY06_10680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_10685	COG0444	Belongs to the ABC transporter superfamily
HPY06_10690	COG4608	Belongs to the ABC transporter superfamily
HPY06_10700	COG2971	BadF BadG BcrA BcrD
HPY06_10720	COG3842	ATPase activity
HPY06_10730	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY06_10735	COG0004	ammonium transporteR
HPY06_10740	COG0347	Belongs to the P(II) protein family
HPY06_10745	COG3112	Uncharacterised protein family (UPF0231)
HPY06_10750	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY06_10755	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY06_10760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY06_10765	COG1643	Atp-dependent helicase
HPY06_10775	COG1489	DNA binding
HPY06_10785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY06_10795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY06_10800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY06_10805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY06_10810	COG0842	Transport permease protein
HPY06_10815	COG1131	(ABC) transporter
HPY06_10820	COG0659	secondary active sulfate transmembrane transporter activity
HPY06_10825	COG0288	reversible hydration of carbon dioxide
HPY06_10840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY06_10845	COG3107	peptidoglycan biosynthetic process
HPY06_10850	COG0792	nuclease activity
HPY06_10855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY06_10860	COG2823	Periplasmic or secreted lipoprotein
HPY06_10865	COG2969	positive regulation of protein catabolic process
HPY06_10870	COG0625	glutathione transferase activity
HPY06_10875	COG2857	Cytochrome c1
HPY06_10880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY06_10885	COG0723	plastoquinol--plastocyanin reductase activity
HPY06_10890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY06_10895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY06_10900	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY06_10910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY06_10915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY06_10920	COG0335	large ribosomal subunit rRNA binding
HPY06_10925	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY06_10930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY06_10935	COG0228	four-way junction DNA binding
HPY06_10940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY06_10945	COG4137	Cytochrome C assembly protein
HPY06_10950	COG4536	flavin adenine dinucleotide binding
HPY06_10955	COG1854	S-ribosylhomocysteine lyase activity
HPY06_10960	COG2918	glutathione biosynthetic process
HPY06_10965	COG0612	Peptidase, M16
HPY06_10970	COG1238	metal cluster binding
HPY06_10980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY06_10985	COG0511	ligase activity, forming carbon-carbon bonds
HPY06_10985	COG5016	pyruvate
HPY06_10990	COG3630	sodium ion export across plasma membrane
HPY06_11035	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY06_11040	COG0527	aspartate kinase activity
HPY06_11045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY06_11050	COG2137	regulation of response to DNA damage stimulus
HPY06_11055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY06_11065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY06_11070	COG4208	sulfate ABC transporter
HPY06_11090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY06_11095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY06_11105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY06_11110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY06_11115	COG0585	pseudouridine synthase activity
HPY06_11120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY06_11125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY06_11130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY06_11135	COG1968	undecaprenyl-diphosphatase activity
HPY06_11140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY06_11145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY06_11150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY06_11160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY06_11165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY06_11170	COG1610	YqeY-like protein
HPY06_11195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY06_11200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY06_11205	COG1349	DNA-binding transcription factor activity
HPY06_11225	COG1279	arginine transmembrane transporter activity
HPY06_11230	COG0668	transmembrane transport
HPY06_11235	COG0191	fructose-bisphosphate aldolase activity
HPY06_11240	COG0126	phosphoglycerate kinase activity
HPY06_11245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY06_11250	COG4771	TonB-dependent receptor
HPY06_11255	COG0583	DNA-binding transcription factor activity
HPY06_11260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY06_11265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY06_11270	COG3091	SprT-like family
HPY06_11275	COG2356	endonuclease I
HPY06_11280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY06_11285	COG0189	ligase activity
HPY06_11290	COG1678	Uncharacterized ACR, COG1678
HPY06_11295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY06_11300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY06_11320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY06_11325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY06_11330	COG0762	integral membrane protein
HPY06_11335	COG1872	DUF167
HPY06_11345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY06_11350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY06_11355	COG2066	Belongs to the glutaminase family
HPY06_11360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY06_11365	COG1194	a g-specific adenine glycosylase
HPY06_11370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY06_11375	COG0741	lytic transglycosylase activity
HPY06_11430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY06_11435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY06_11440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY06_11445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY06_11450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY06_11455	COG2967	ApaG domain
HPY06_11460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY06_11470	COG3610	response to peptide
HPY06_11475	COG2966	Psort location CytoplasmicMembrane, score
HPY06_11480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY06_11485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY06_11490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY06_11495	COG0142	geranyltranstransferase activity
HPY06_11500	COG0531	amino acid
HPY06_11505	COG0039	L-malate dehydrogenase activity
HPY06_11510	COG1438	arginine binding
HPY06_11515	COG2358	TRAP transporter, solute receptor (TAXI family
HPY06_11525	COG0589	response to stress
HPY06_11545	COG2235	arginine
HPY06_11550	COG0312	modulator of DNA gyrase
HPY06_11555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY06_11560	COG3164	Protein of unknown function
HPY06_11565	COG1530	ribonuclease E activity
HPY06_11570	COG0424	maF-like protein
HPY06_11575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY06_11580	COG1792	Involved in formation and maintenance of cell shape
HPY06_11585	COG1077	Cell shape determining protein MreB Mrl
HPY06_11630	COG1459	type II secretion system
HPY06_11635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY06_11645	COG3267	Type II secretory pathway component ExeA
HPY06_11645	COG3409	Peptidoglycan-binding domain 1 protein
HPY06_11670	COG2200	EAL domain
HPY06_11670	COG2199	diguanylate cyclase activity
HPY06_11675	COG0629	single-stranded DNA binding
HPY06_11690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY06_11700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY06_11705	COG0527	aspartate kinase activity
HPY06_11710	COG0646	methionine synthase
HPY06_11710	COG1410	methionine synthase
HPY06_11785	COG0175	sulfate reduction
HPY06_11790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPY06_11795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY06_11820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY06_11825	COG0735	belongs to the Fur family
HPY06_11845	COG0432	Pfam Uncharacterised protein family UPF0047
HPY06_11850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY06_11865	COG0359	binds to the 23S rRNA
HPY06_11870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY06_11875	COG2965	DNA replication, synthesis of RNA primer
HPY06_11880	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY06_11890	COG2906	2 iron, 2 sulfur cluster binding
HPY06_11895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY06_11900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY06_11905	COG0049	tRNA binding
HPY06_11920	COG2923	Belongs to the DsrF TusC family
HPY06_11925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY06_11930	COG2964	Protein conserved in bacteria
HPY06_11935	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY06_11945	COG2900	Belongs to the SlyX family
HPY06_11950	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY06_11955	COG0330	HflC and HflK could
HPY06_11960	COG0330	HflC and HflK could
HPY06_11965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY06_11970	COG1923	regulation of RNA biosynthetic process
HPY06_11975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY06_11980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY06_11990	COG0802	atpase or kinase
HPY06_11995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY06_12045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY06_12050	COG1162	GTPase activity
HPY06_12055	COG0688	phosphatidylethanolamine metabolic process
HPY06_12060	COG0471	metal ion transport
HPY06_12070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY06_12075	COG4942	peptidase
HPY06_12090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY06_12095	COG2816	NAD+ diphosphatase activity
HPY06_12100	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY06_12105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY06_12110	COG0085	RNA polymerase activity
HPY06_12115	COG0222	ribosome binding
HPY06_12120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY06_12130	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY06_12135	COG0250	Participates in transcription elongation, termination and antitermination
HPY06_12140	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY06_12145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY06_12170	COG1072	(Pantothenic acid kinase))
HPY06_12180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY06_12190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY06_12235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY06_12250	COG3118	belongs to the thioredoxin family
HPY06_12255	COG0513	Belongs to the DEAD box helicase family
HPY06_12260	COG0248	Ppx GppA phosphatase
HPY06_12265	COG2205	protein histidine kinase activity
HPY06_12265	COG0784	Response regulator, receiver
HPY06_12270	COG2814	Major facilitator Superfamily
HPY06_12285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY06_12290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY06_12295	COG0511	ligase activity, forming carbon-carbon bonds
HPY06_12300	COG0439	Biotin carboxylase
HPY06_12305	COG2264	protein methyltransferase activity
HPY06_12310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY06_12315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY06_12320	COG1609	Transcriptional regulator
HPY06_12330	COG0387	Pfam Sodium calcium exchanger
HPY06_12335	COG0129	dihydroxy-acid dehydratase activity
HPY06_12340	COG3265	gluconokinase activity
HPY06_12350	COG0800	Aldolase
HPY06_12370	COG0840	transmembrane signaling receptor activity
HPY06_12375	COG1982	Orn Lys Arg decarboxylase major
HPY06_12380	COG0531	amino acid
HPY06_12385	COG3710	Transcriptional regulator
HPY06_12390	COG0789	Transcriptional regulator
HPY06_12405	COG0151	Belongs to the GarS family
HPY06_12415	COG0776	regulation of translation
HPY06_12420	COG1253	flavin adenine dinucleotide binding
HPY06_12455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_12460	COG3068	Protein conserved in bacteria
HPY06_12470	COG1573	uracil-dna glycosylase
HPY06_12475	COG0668	transmembrane transport
HPY06_12480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY06_12490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY06_12515	COG1086	Polysaccharide biosynthesis protein
HPY06_12525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY06_12530	COG0482	sulfurtransferase activity
HPY06_12585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY06_12600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY06_12625	COG0859	PFAM glycosyl transferase family 9
HPY06_12635	COG1519	Transferase
HPY06_12660	COG3642	lipopolysaccharide core region biosynthetic process
HPY06_12665	COG0859	PFAM glycosyl transferase family 9
HPY06_12670	COG0463	Glycosyl transferase, family 2
HPY06_12675	COG0859	PFAM glycosyl transferase family 9
HPY06_12680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY06_12685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY06_12695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY06_12700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY06_12705	COG2003	Belongs to the UPF0758 family
HPY06_12715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY06_12725	COG1309	transcriptional regulator
HPY06_12730	COG1560	Kdo2-lipid A biosynthetic process
HPY06_12735	COG1560	Kdo2-lipid A biosynthetic process
HPY06_12740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY06_12745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY06_12750	COG1561	YicC-like family, N-terminal region
HPY06_12755	COG2862	Uncharacterized protein family, UPF0114
HPY06_12760	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY06_12765	COG1263	PTS System
HPY06_12765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_12770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY06_12790	COG1120	ATPase activity
HPY06_12795	COG4774	siderophore transport
HPY06_12800	COG1132	(ABC) transporter
HPY06_12815	COG0514	ATP-dependent DNA helicase (RecQ)
HPY06_12820	COG2962	Rard protein
HPY06_12825	COG0405	Gamma-glutamyltransferase
HPY06_12835	COG1280	lysine exporter protein (LysE YggA)
HPY06_12845	COG0210	DNA helicase
HPY06_12855	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY06_12860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_12870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_12880	COG0747	negative chemotaxis
HPY06_12930	COG1309	transcriptional regulator
HPY06_12935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_12940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY06_12945	COG2960	long-chain fatty acid transporting porin activity
HPY06_12950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY06_12955	COG0583	DNA-binding transcription factor activity
HPY06_13025	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY06_13030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY06_13035	COG1739	Uncharacterized protein family UPF0029
HPY06_13040	COG1024	Enoyl-CoA hydratase
HPY06_13040	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY06_13045	COG0183	Belongs to the thiolase family
HPY06_13050	COG0583	DNA-binding transcription factor activity
HPY06_13055	COG2814	Major facilitator Superfamily
HPY06_13065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY06_13070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY06_13075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY06_13080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY06_13085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY06_13090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY06_13100	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY06_13105	COG3312	ion transport
HPY06_13110	COG1475	DNA binding
HPY06_13115	COG1192	Involved in chromosome partitioning
HPY06_13120	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY06_13125	COG0445	tRNA wobble uridine modification
HPY06_13130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY06_13135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY06_13140	COG0706	membrane insertase activity
HPY06_13150	COG0594	ribonuclease P activity
HPY06_13155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY06_13160	COG1126	abc transporter atp-binding protein
HPY06_13205	COG0217	transcriptional regulatory protein
HPY06_13210	COG2084	Dehydrogenase
HPY06_13225	COG2909	trisaccharide binding
HPY06_13230	COG0058	SHG alpha-glucan phosphorylase activity
HPY06_13235	COG1640	4-alpha-glucanotransferase
HPY06_13240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY06_13250	COG3501	Rhs element vgr protein
HPY06_13285	COG0471	metal ion transport
HPY06_13290	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY06_13320	COG0671	phosphoesterase, PA-phosphatase related
HPY06_13330	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY06_13340	COG1999	signal sequence binding
HPY06_13355	COG0786	glutamate:sodium symporter activity
HPY06_13375	COG1566	PFAM secretion protein HlyD family protein
HPY06_13385	COG3706	GGDEF domain
HPY06_13400	COG0813	purine-nucleoside phosphorylase activity
HPY06_13405	COG3272	Protein of unknown function (DUF1722)
HPY06_13415	COG0415	Belongs to the DNA photolyase family
HPY06_13420	COG1376	ErfK ybiS ycfS ynhG family protein
HPY06_13420	COG1388	LysM domain
HPY06_13430	COG0513	Belongs to the DEAD box helicase family
HPY06_13435	COG1770	oligopeptidase
HPY06_13460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY06_13465	COG0573	inorganic phosphate transmembrane transporter activity
HPY06_13470	COG0581	inorganic phosphate transmembrane transporter activity
HPY06_13475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY06_13495	COG0659	secondary active sulfate transmembrane transporter activity
HPY06_13505	COG0739	heme binding
HPY06_13510	COG5001	Diguanylate cyclase
HPY06_13510	COG3300	MHYT domain
HPY06_13515	COG0583	DNA-binding transcription factor activity
HPY06_13520	COG2814	Major facilitator Superfamily
HPY06_13540	COG1301	dicarboxylic acid transport
HPY06_13555	COG1342	Belongs to the UPF0251 family
HPY06_13590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY06_13595	COG0673	inositol 2-dehydrogenase activity
HPY06_13605	COG2200	EAL domain
HPY06_13605	COG2771	luxR family
HPY06_13610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY06_13620	COG0564	pseudouridine synthase activity
HPY06_13710	COG3501	Rhs element vgr protein
HPY06_13740	COG1869	D-ribose catabolic process
HPY06_13745	COG1129	ABC transporter
HPY06_13750	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY06_13755	COG1879	ABC-type sugar transport system periplasmic component
HPY06_13760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_13765	COG1609	Transcriptional regulator
HPY06_13775	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY06_13785	COG0584	glycerophosphoryl diester phosphodiesterase
HPY06_13790	COG2271	Major facilitator Superfamily
HPY06_13825	COG0579	oxidoreductase
HPY06_13835	COG0242	peptide deformylase activity
HPY06_13840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY06_13840	COG1017	nitric oxide dioxygenase activity
HPY06_13845	COG1320	monovalent cation:proton antiporter activity
HPY06_13850	COG2212	antiporter activity
HPY06_13870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY06_13870	COG2111	Na H antiporter
HPY06_13880	COG0589	response to stress
HPY06_13885	COG0814	amino acid
HPY06_13900	COG3530	Putative quorum-sensing-regulated virulence factor
HPY06_13910	COG5002	protein histidine kinase activity
HPY06_13910	COG5001	Diguanylate cyclase
HPY06_13915	COG1278	Cold shock
HPY06_13930	COG2304	oxidoreductase activity
HPY06_13950	COG0714	Associated with various cellular activities
HPY06_13955	COG0840	transmembrane signaling receptor activity
HPY06_13970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY06_13975	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY06_13985	COG3604	Transcriptional regulator
HPY06_13990	COG1017	nitric oxide dioxygenase activity
HPY06_13990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY06_13995	COG1278	Cold shock
HPY06_14000	COG3036	rescue of stalled ribosome
HPY06_14025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY06_14025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY06_14030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY06_14040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY06_14050	COG0516	GMP reductase activity
HPY06_14080	COG0513	Belongs to the DEAD box helicase family
HPY06_14085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY06_14090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY06_14095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY06_14100	COG0784	Response regulator, receiver
HPY06_14100	COG3437	response regulator, receiver
HPY06_14110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_14110	COG4191	Histidine kinase
HPY06_14120	COG1757	Na H antiporter
HPY06_14125	COG2814	Major facilitator Superfamily
HPY06_14135	COG3240	lipase activity
HPY06_14145	COG0840	transmembrane signaling receptor activity
HPY06_14150	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY06_14155	COG5380	lipid catabolic process
HPY06_14180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_14185	COG4605	iron ion homeostasis
HPY06_14190	COG4604	ABC transporter, ATP-binding protein
HPY06_14195	COG2207	Transcriptional regulator
HPY06_14210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY06_14225	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY06_14235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_14245	COG0583	DNA-binding transcription factor activity
HPY06_14265	COG0745	RESPONSE REGULATOR receiver
HPY06_14275	COG3623	hexulose-6-phosphate isomerase
HPY06_14280	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY06_14285	COG0561	phosphatase activity
HPY06_14335	COG0745	RESPONSE REGULATOR receiver
HPY06_14340	COG5002	protein histidine kinase activity
HPY06_14365	COG0583	DNA-binding transcription factor activity
HPY06_14380	COG1686	Belongs to the peptidase S11 family
HPY06_14400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY06_14400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY06_14405	COG0509	glycine decarboxylation via glycine cleavage system
HPY06_14410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY06_14420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY06_14435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY06_14440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY06_14535	COG0454	-acetyltransferase
HPY06_14555	COG0456	acetyltransferase
HPY06_14710	COG5642	Protein of unknown function (DUF2384)
HPY06_14810	COG0456	acetyltransferase
HPY06_14845	COG0456	acetyltransferase
HPY06_14865	COG3549	Plasmid maintenance system killer
HPY06_14870	COG3093	addiction module antidote protein HigA
HPY06_15075	COG1418	mRNA catabolic process
HPY06_15130	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY06_15150	COG0454	-acetyltransferase
HPY06_15185	COG0454	-acetyltransferase
HPY06_15275	COG0653	protein targeting
HPY06_15290	COG2801	Transposase and inactivated derivatives
HPY06_15300	COG3158	transport of potassium into the cell
HPY06_15305	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY06_15305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY06_15305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY06_15305	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY06_15310	COG2205	protein histidine kinase activity
HPY06_15315	COG0745	RESPONSE REGULATOR receiver
HPY06_15320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY06_15325	COG0586	Pfam SNARE associated Golgi protein
HPY06_15335	COG2200	EAL domain
HPY06_15345	COG3038	cytochrome b561
HPY06_15355	COG2116	formate transmembrane transporter activity
HPY06_15360	COG0583	DNA-binding transcription factor activity
HPY06_15370	COG3593	DNA synthesis involved in DNA repair
HPY06_15375	COG0737	Belongs to the 5'-nucleotidase family
HPY06_15390	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY06_15440	COG3706	GGDEF domain
HPY06_15455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY06_15460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY06_15470	COG0745	RESPONSE REGULATOR receiver
HPY06_15485	COG3140	Belongs to the UPF0181 family
HPY06_15555	COG0023	Translation Initiation Factor
HPY06_15575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_15575	COG1042	CoA-binding domain protein
HPY06_15575	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY06_15580	COG0583	DNA-binding transcription factor activity
HPY06_15585	COG4771	TonB-dependent receptor
HPY06_15600	COG2050	protein possibly involved in aromatic compounds catabolism
HPY06_15620	COG0625	glutathione transferase activity
HPY06_15635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY06_15640	COG4172	Belongs to the ABC transporter superfamily
HPY06_15645	COG4239	(ABC) transporter, permease
HPY06_15650	COG4174	ABC transporter (Permease)
HPY06_15655	COG4166	transmembrane transport
HPY06_15680	COG3104	oligopeptide transport
HPY06_15700	COG3842	ATPase activity
HPY06_15710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY06_15720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY06_15725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY06_15730	COG1011	Hydrolase
HPY06_15740	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY06_15745	COG1970	mechanosensitive ion channel activity
HPY06_15750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY06_15755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_15755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_15760	COG0302	gtp cyclohydrolase
HPY06_15770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY06_15780	COG2897	thiosulfate sulfurtransferase activity
HPY06_15785	COG2390	Transcriptional regulator
HPY06_15800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY06_15830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY06_15855	COG0583	DNA-binding transcription factor activity
HPY06_15860	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY06_15900	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY06_15945	COG1263	PTS System
HPY06_15945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_15955	COG1621	beta-fructofuranosidase activity
HPY06_15960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_15965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY06_15975	COG2885	chlorophyll binding
HPY06_15980	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY06_16050	COG0384	phenazine biosynthesis protein PhzF
HPY06_16060	COG3093	addiction module antidote protein HigA
HPY06_16065	COG3549	Plasmid maintenance system killer
HPY06_16070	COG4977	sequence-specific DNA binding
HPY06_16115	COG4115	mRNA cleavage
HPY06_16120	COG2161	toxin-antitoxin pair type II binding
HPY06_16145	COG3040	lipid binding
HPY06_16215	COG0494	nUDIX hydrolase
HPY06_16245	COG3093	addiction module antidote protein HigA
HPY06_16250	COG3549	Plasmid maintenance system killer
HPY06_16270	COG3041	Addiction module toxin RelE StbE family
HPY06_16435	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY06_16465	COG2801	Transposase and inactivated derivatives
HPY06_16470	COG0523	cobalamin synthesis protein
HPY06_16475	COG0038	chloride channel
HPY06_16485	COG0156	8-amino-7-oxononanoate synthase activity
HPY06_16490	COG2205	protein histidine kinase activity
HPY06_16490	COG0784	Response regulator, receiver
HPY06_16495	COG0419	ATPase involved in DNA repair
HPY06_16500	COG0420	3'-5' exonuclease activity
HPY06_16505	COG1609	Transcriptional regulator
HPY06_16510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_16510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_16515	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY06_16520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_16520	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY06_16520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_16525	COG4067	protein conserved in archaea
HPY06_16525	COG0189	ligase activity
HPY06_16535	COG0602	queuosine metabolic process
HPY06_16540	COG1328	CTP reductase activity
HPY06_16550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY06_16555	COG0840	transmembrane signaling receptor activity
HPY06_16560	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY06_16565	COG1760	l-serine dehydratase
HPY06_16570	COG2197	response regulator
HPY06_16575	COG3850	Histidine kinase
HPY06_16580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY06_16590	COG0243	molybdopterin cofactor binding
HPY06_16610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY06_16615	COG2197	response regulator
HPY06_16620	COG3851	Histidine kinase
HPY06_16625	COG2271	Major facilitator Superfamily
HPY06_16630	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY06_16640	COG3842	ATPase activity
HPY06_16645	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY06_16655	COG0183	Belongs to the thiolase family
HPY06_16665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_16670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_16685	COG3706	GGDEF domain
HPY06_16690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY06_16700	COG1979	alcohol dehydrogenase
HPY06_16715	COG4191	Histidine kinase
HPY06_16725	COG2271	Major facilitator Superfamily
HPY06_16730	COG0469	pyruvate kinase activity
HPY06_16735	COG2205	protein histidine kinase activity
HPY06_16735	COG0784	Response regulator, receiver
HPY06_16735	COG2198	Histidine kinase
HPY06_16740	COG1879	ABC-type sugar transport system periplasmic component
HPY06_16745	COG1803	Methylglyoxal synthase
HPY06_16750	COG1335	isochorismatase
HPY06_16755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY06_16770	COG0210	DNA helicase
HPY06_16775	COG1289	transmembrane transporter activity
HPY06_16805	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY06_16810	COG4149	molybdate abc transporter
HPY06_16815	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY06_16820	COG1492	cobalamin metabolic process
HPY06_16860	COG4977	sequence-specific DNA binding
HPY06_16860	COG1917	Cupin 2, conserved barrel domain protein
HPY06_16870	COG2814	Major facilitator Superfamily
HPY06_16875	COG2226	methyltransferase
HPY06_16875	COG3433	isochorismatase activity
HPY06_16875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY06_16900	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY06_16905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY06_16925	COG1132	(ABC) transporter
HPY06_16930	COG1132	(ABC) transporter
HPY06_16940	COG5002	protein histidine kinase activity
HPY06_16940	COG0784	Response regulator, receiver
HPY06_16945	COG1879	ABC-type sugar transport system periplasmic component
HPY06_16955	COG2827	Endonuclease containing a URI domain
HPY06_16960	COG3132	Protein of unknown function, DUF480
HPY06_16970	COG2926	Belongs to the UPF0265 family
HPY06_16980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY06_16985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY06_16990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY06_17000	COG0247	lactate metabolic process
HPY06_17005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY06_17010	COG3118	belongs to the thioredoxin family
HPY06_17035	COG4160	amino acid transport
HPY06_17040	COG4215	(ABC) transporter
HPY06_17045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_17050	COG1126	abc transporter atp-binding protein
HPY06_17060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY06_17070	COG0494	nUDIX hydrolase
HPY06_17075	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY06_17085	COG1309	transcriptional regulator
HPY06_17090	COG0513	Belongs to the DEAD box helicase family
HPY06_17095	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY06_17100	COG0814	amino acid
HPY06_17105	COG0840	transmembrane signaling receptor activity
HPY06_17110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY06_17115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY06_17125	COG1984	allophanate hydrolase subunit 2
HPY06_17140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY06_17145	COG4181	ATPase activity
HPY06_17155	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY06_17160	COG1716	ATPase activity
HPY06_17160	COG5001	Diguanylate cyclase
HPY06_17170	COG0484	heat shock protein binding
HPY06_17185	COG0546	phosphoglycolate phosphatase activity
HPY06_17200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_17210	COG0513	Belongs to the DEAD box helicase family
HPY06_17225	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY06_17235	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY06_17240	COG3397	chitin binding
HPY06_17245	COG3227	Zinc metalloprotease (Elastase)
HPY06_17255	COG0010	Belongs to the arginase family
HPY06_17260	COG1166	arginine decarboxylase activity
HPY06_17270	COG2239	Acts as a magnesium transporter
HPY06_17280	COG0527	aspartate kinase activity
HPY06_17285	COG0662	Cupin 2, conserved barrel domain protein
HPY06_17290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY06_17295	COG0456	acetyltransferase
HPY06_17300	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY06_17305	COG3186	Phenylalanine-4-hydroxylase
HPY06_17310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY06_17325	COG2264	protein methyltransferase activity
HPY06_17350	COG1253	flavin adenine dinucleotide binding
HPY06_17355	COG1765	OsmC-like protein
HPY06_17385	COG1252	NADH dehydrogenase
HPY06_17390	COG0531	amino acid
HPY06_17395	COG3706	GGDEF domain
HPY06_17405	COG3279	Response regulator of the LytR AlgR family
HPY06_17410	COG3275	phosphorelay sensor kinase activity
HPY06_17425	COG0577	efflux transmembrane transporter activity
HPY06_17425	COG1136	(ABC) transporter
HPY06_17430	COG1136	(ABC) transporter
HPY06_17440	COG4989	oxidoreductase activity
HPY06_17445	COG0366	Alpha amylase catalytic
HPY06_17455	COG2067	long-chain fatty acid transport protein
HPY06_17460	COG2267	carboxylic ester hydrolase activity
HPY06_17470	COG3227	Zinc metalloprotease (Elastase)
HPY06_17475	COG3047	cAMP biosynthetic process
HPY06_17485	COG1686	Belongs to the peptidase S11 family
HPY06_17490	COG0557	exoribonuclease II activity
HPY06_17495	COG1278	Cold shock
HPY06_17505	COG3048	D-serine ammonia-lyase activity
HPY06_17510	COG0583	DNA-binding transcription factor activity
HPY06_17525	COG2801	Transposase and inactivated derivatives
HPY06_17555	COG1063	alcohol dehydrogenase
HPY06_17560	COG0156	8-amino-7-oxononanoate synthase activity
HPY06_17580	COG0346	lactoylglutathione lyase activity
HPY06_17600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY06_17605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY06_17610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY06_17615	COG0363	glucosamine-6-phosphate deaminase activity
HPY06_17620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY06_17645	COG1929	Belongs to the glycerate kinase type-1 family
HPY06_17650	COG2610	gluconate transmembrane transporter activity
HPY06_17655	COG3835	regulator
HPY06_17665	COG0748	coenzyme F420 binding
HPY06_17670	COG3721	Heme iron utilization protein
HPY06_17680	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY06_17685	COG0811	peptide transport
HPY06_17690	COG0848	biopolymer transport protein
HPY06_17695	COG4558	Periplasmic binding protein
HPY06_17700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_17705	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY06_17740	COG0633	Ferredoxin
HPY06_17740	COG3217	Mosc domain protein beta barrel domain protein
HPY06_17740	COG3217	Mosc domain protein beta barrel domain protein
HPY06_17740	COG0633	Ferredoxin
HPY06_17745	COG0418	dihydroorotase activity
HPY06_17750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY06_17755	COG2354	Protein conserved in bacteria
HPY06_17765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY06_17770	COG1278	Cold shock
HPY06_17795	COG3706	GGDEF domain
HPY06_17800	COG1349	DNA-binding transcription factor activity
HPY06_17815	COG3833	ABC-type maltose transport systems, permease component
HPY06_17820	COG1175	transmembrane transport
HPY06_17830	COG3842	ATPase activity
HPY06_17835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_17850	COG0393	Putative heavy-metal-binding
HPY06_17860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY06_17865	COG0835	chemotaxis
HPY06_17865	COG0784	Response regulator, receiver
HPY06_17870	COG1846	Transcriptional regulator
HPY06_17910	COG0583	DNA-binding transcription factor activity
HPY06_17915	COG5001	Diguanylate cyclase
HPY06_17925	COG1741	Belongs to the pirin family
HPY06_17930	COG3123	guanosine phosphorylase activity
HPY06_17940	COG2211	Major facilitator Superfamily
HPY06_17945	COG0840	transmembrane signaling receptor activity
HPY06_17950	COG1067	ATP-dependent peptidase activity
HPY06_17960	COG4172	Belongs to the ABC transporter superfamily
HPY06_17980	COG0583	DNA-binding transcription factor activity
HPY06_17990	COG1620	l-lactate permease
HPY06_18005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY06_18015	COG0840	transmembrane signaling receptor activity
HPY06_18035	COG2258	MOSC domain
HPY06_18040	COG0513	Belongs to the DEAD box helicase family
HPY06_18050	COG2186	Transcriptional regulator
HPY06_18060	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY06_18070	COG0246	Mannitol dehydrogenase
HPY06_18075	COG1904	glucuronate isomerase
HPY06_18080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_18085	COG0800	Aldolase
HPY06_18095	COG0583	DNA-binding transcription factor activity
HPY06_18105	COG1902	pentaerythritol trinitrate reductase activity
HPY06_18115	COG1132	(ABC) transporter
HPY06_18125	COG1902	pentaerythritol trinitrate reductase activity
HPY06_18135	COG1280	lysine exporter protein (LysE YggA)
HPY06_18140	COG2207	Transcriptional regulator
HPY06_18160	COG1846	Transcriptional regulator
HPY06_18165	COG1764	response to oxidative stress
HPY06_18170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY06_18175	COG0697	spore germination
HPY06_18185	COG0700	Nucleoside recognition
HPY06_18190	COG3366	ferrous iron transmembrane transporter activity
HPY06_18195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY06_18205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY06_18210	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY06_18215	COG2259	Doxx family
HPY06_18240	COG0363	glucosamine-6-phosphate deaminase activity
HPY06_18255	COG4580	involved in the transport of maltose and maltodextrins
HPY06_18270	COG0840	transmembrane signaling receptor activity
HPY06_18280	COG0840	transmembrane signaling receptor activity
HPY06_18285	COG3706	GGDEF domain
HPY06_18295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY06_18300	COG1126	abc transporter atp-binding protein
HPY06_18310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_18315	COG4597	amino acid ABC transporter
HPY06_18320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY06_18325	COG2213	PTS system mannitol-specific
HPY06_18325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_18330	COG0246	Mannitol dehydrogenase
HPY06_18335	COG3722	fumarate hydratase activity
HPY06_18370	COG2910	NAD(P)H-binding
HPY06_18380	COG0840	transmembrane signaling receptor activity
HPY06_18385	COG4221	oxidoreductase activity
HPY06_18395	COG1901	pseudouridine methyltransferase
HPY06_18405	COG0531	amino acid
HPY06_18410	COG1982	Orn Lys Arg decarboxylase major
HPY06_18420	COG2197	response regulator
HPY06_18460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY06_18485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY06_18550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY06_18555	COG0840	transmembrane signaling receptor activity
HPY06_18560	COG0835	chemotaxis
HPY06_18565	COG0835	chemotaxis
HPY06_18570	COG0643	Histidine kinase
HPY06_18570	COG2198	Histidine kinase
HPY06_18590	COG0601	transmembrane transport
HPY06_18595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_18600	COG4608	Belongs to the ABC transporter superfamily
HPY06_18605	COG2194	sulfuric ester hydrolase activity
HPY06_18610	COG0642	Histidine kinase
HPY06_18615	COG0745	RESPONSE REGULATOR receiver
HPY06_18645	COG1444	tRNA N-acetyltransferase activity
HPY06_18650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine