locus-tag	class	description
HPY15_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY15_00010	COG0592	DNA-directed DNA polymerase activity
HPY15_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY15_00020	COG0187	DNA topoisomerase II activity
HPY15_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY15_00035	COG3977	Valine--pyruvate aminotransferase
HPY15_00040	COG0751	glycine-tRNA ligase activity
HPY15_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY15_00050	COG2119	membrane
HPY15_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY15_00070	COG0604	alcohol dehydrogenase
HPY15_00080	COG0129	dihydroxy-acid dehydratase activity
HPY15_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY15_00100	COG0606	chelatase, subunit chli
HPY15_00105	COG0204	Acyl-transferase
HPY15_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY15_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY15_00125	COG3084	Protein conserved in bacteria
HPY15_00130	COG4326	sporulation control protein
HPY15_00135	COG1272	protein, Hemolysin III
HPY15_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY15_00150	COG0569	domain protein
HPY15_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY15_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY15_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY15_00165	COG0242	peptide deformylase activity
HPY15_00170	COG1652	LysM domain
HPY15_00175	COG0758	DNA mediated transformation
HPY15_00180	COG2922	Belongs to the Smg family
HPY15_00185	COG0551	DNA topoisomerase type I activity
HPY15_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY15_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY15_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY15_00205	COG0408	coproporphyrinogen oxidase activity
HPY15_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY15_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY15_00255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY15_00260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY15_00270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY15_00275	COG2104	thiamine diphosphate biosynthetic process
HPY15_00280	COG2022	thiamine diphosphate biosynthetic process
HPY15_00285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY15_00290	COG0006	proline dipeptidase activity
HPY15_00290	COG0006	proline dipeptidase activity
HPY15_00310	COG1522	sequence-specific DNA binding
HPY15_00315	COG5002	protein histidine kinase activity
HPY15_00315	COG5001	Diguanylate cyclase
HPY15_00335	COG0589	response to stress
HPY15_00340	COG1528	Iron-storage protein
HPY15_00350	COG2081	HI0933 family
HPY15_00360	COG1322	Protein conserved in bacteria
HPY15_00365	COG2226	methyltransferase
HPY15_00380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY15_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY15_00390	COG0805	protein transport
HPY15_00395	COG1858	cytochrome C peroxidase
HPY15_00400	COG0534	Mate efflux family protein
HPY15_00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY15_00415	COG2937	Belongs to the GPAT DAPAT family
HPY15_00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY15_00425	COG3161	chorismate lyase activity
HPY15_00430	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY15_00435	COG0840	transmembrane signaling receptor activity
HPY15_00445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY15_00450	COG0084	hydrolase, TatD family'
HPY15_00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY15_00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY15_00485	COG3078	GTPase activator activity
HPY15_00500	COG3071	HemY protein
HPY15_00505	COG2959	enzyme of heme biosynthesis
HPY15_00510	COG1587	Uroporphyrinogen-III synthase
HPY15_00515	COG0181	hydroxymethylbilane synthase activity
HPY15_00525	COG1965	Belongs to the frataxin family
HPY15_00535	COG0019	diaminopimelate decarboxylase activity
HPY15_00540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY15_00550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY15_00555	COG1011	Hydrolase
HPY15_00560	COG2199	diguanylate cyclase activity
HPY15_00560	COG2200	EAL domain
HPY15_00560	COG3287	FIST C domain
HPY15_00575	COG0561	phosphatase activity
HPY15_00580	COG2267	carboxylic ester hydrolase activity
HPY15_00585	COG1280	lysine exporter protein (LysE YggA)
HPY15_00590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY15_00595	COG0783	Belongs to the Dps family
HPY15_00625	COG0742	ribosomal rna small subunit methyltransferase
HPY15_00630	COG0552	protein localization to endoplasmic reticulum
HPY15_00635	COG2884	Cell division ATP-binding protein ftsE
HPY15_00640	COG2177	Part of the ABC transporter FtsEX involved in
HPY15_00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY15_00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY15_00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY15_00680	COG1404	Belongs to the peptidase S8 family
HPY15_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY15_00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY15_00755	COG3300	MHYT domain
HPY15_00755	COG5001	Diguanylate cyclase
HPY15_00765	COG3852	Histidine kinase
HPY15_00775	COG0174	glutamine synthetase
HPY15_00795	COG1295	ribonuclease BN
HPY15_00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY15_00805	COG0456	acetyltransferase
HPY15_00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY15_00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY15_00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY15_00830	COG3031	protein transport across the cell outer membrane
HPY15_00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY15_00845	COG1459	type II secretion system
HPY15_00850	COG2165	general secretion pathway protein
HPY15_00855	COG2165	general secretion pathway protein
HPY15_00860	COG2165	general secretion pathway protein
HPY15_00865	COG4795	General secretion pathway protein
HPY15_00870	COG3156	type II secretion system protein K
HPY15_00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY15_00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY15_00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY15_00895	COG0494	nUDIX hydrolase
HPY15_00905	COG1040	competence protein
HPY15_00915	COG0596	Alpha beta hydrolase
HPY15_00925	COG2183	response to ionizing radiation
HPY15_00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY15_00935	COG2199	diguanylate cyclase activity
HPY15_00940	COG0745	RESPONSE REGULATOR receiver
HPY15_00950	COG2233	PERMEase
HPY15_00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY15_00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY15_00965	COG1758	RNA polymerase activity
HPY15_00970	COG0194	GDP metabolic process
HPY15_00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY15_00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY15_01000	COG4232	protein-disulfide reductase activity
HPY15_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY15_01015	COG1027	Aspartate ammonia-lyase
HPY15_01020	COG3706	GGDEF domain
HPY15_01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY15_01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY15_01040	COG2205	protein histidine kinase activity
HPY15_01045	COG0745	RESPONSE REGULATOR receiver
HPY15_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY15_01060	COG0205	6-phosphofructokinase activity
HPY15_01065	COG1494	fructose-1,6-bisphosphatase
HPY15_01070	COG3074	FtsZ-dependent cytokinesis
HPY15_01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY15_01080	COG0460	homoserine dehydrogenase
HPY15_01080	COG0527	aspartate kinase activity
HPY15_01085	COG0626	cystathionine gamma-synthase activity
HPY15_01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY15_01095	COG0281	malic enzyme
HPY15_01100	COG0254	rRNA binding
HPY15_01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY15_01110	COG1609	Transcriptional regulator
HPY15_01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY15_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY15_01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY15_01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY15_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY15_01140	COG0534	Mate efflux family protein
HPY15_01145	COG0149	triose-phosphate isomerase activity
HPY15_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY15_01175	COG0459	protein refolding
HPY15_01185	COG1509	lysine 2,3-aminomutase activity
HPY15_01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY15_01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY15_01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY15_01210	COG1053	succinate dehydrogenase
HPY15_01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY15_01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY15_01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY15_01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY15_01235	COG1045	serine acetyltransferase
HPY15_01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY15_01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY15_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY15_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY15_01265	COG0137	argininosuccinate synthase activity
HPY15_01270	COG0165	Argininosuccinate lyase
HPY15_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY15_01285	COG0678	peroxiredoxin activity
HPY15_01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY15_01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY15_01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY15_01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY15_01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY15_01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY15_01350	COG0546	phosphoglycolate phosphatase activity
HPY15_01355	COG0180	Tryptophanyl-tRNA synthetase
HPY15_01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY15_01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY15_01405	COG3954	Phosphoribulokinase
HPY15_01415	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY15_01425	COG0488	(ABC) transporter
HPY15_01430	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY15_01445	COG1047	Peptidyl-prolyl cis-trans
HPY15_01455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY15_01460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY15_01465	COG3083	sulfuric ester hydrolase activity
HPY15_01470	COG0557	exoribonuclease II activity
HPY15_01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY15_01480	COG0051	transcription antitermination factor activity, RNA binding
HPY15_01485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY15_01490	COG0088	Forms part of the polypeptide exit tunnel
HPY15_01495	COG0089	rRNA binding
HPY15_01500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY15_01505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY15_01510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY15_01515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY15_01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY15_01525	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY15_01530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY15_01535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY15_01540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY15_01545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY15_01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY15_01555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY15_01560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY15_01565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY15_01570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY15_01575	COG1841	ribosomal large subunit assembly
HPY15_01585	COG0201	protein transport
HPY15_01590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY15_01595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY15_01600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY15_01605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY15_01610	COG0202	RNA polymerase activity
HPY15_01615	COG0203	ribosomal protein L17
HPY15_01625	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY15_01630	COG3266	domain, Protein
HPY15_01630	COG3061	Opacity-associated protein A
HPY15_01635	COG0697	spore germination
HPY15_01640	COG2153	protein acetylation
HPY15_01645	COG0513	Belongs to the DEAD box helicase family
HPY15_01655	COG0737	Belongs to the 5'-nucleotidase family
HPY15_01660	COG1648	precorrin-2 dehydrogenase activity
HPY15_01660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY15_01670	COG2895	sulfate adenylyltransferase (ATP) activity
HPY15_01675	COG0529	Catalyzes the synthesis of activated sulfate
HPY15_01695	COG1136	(ABC) transporter
HPY15_01710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY15_01715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY15_01720	COG0729	surface antigen
HPY15_01730	COG2105	PFAM AIG2 family protein
HPY15_01735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY15_01745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY15_01750	COG0163	prenyltransferase activity
HPY15_01760	COG1178	ABC-type Fe3 transport system permease component
HPY15_01765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY15_01770	COG3028	Belongs to the UPF0307 family
HPY15_01775	COG0312	modulator of DNA gyrase
HPY15_01780	COG2239	Acts as a magnesium transporter
HPY15_01785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY15_01790	COG1660	Displays ATPase and GTPase activities
HPY15_01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY15_01800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY15_01810	COG1137	ATPase activity
HPY15_01815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY15_01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY15_01830	COG0517	IMP dehydrogenase activity
HPY15_01840	COG1127	ABC transporter
HPY15_01845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY15_01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY15_01855	COG2854	intermembrane phospholipid transfer
HPY15_01865	COG5007	Belongs to the BolA IbaG family
HPY15_01870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY15_01880	COG0251	oxidation-reduction process
HPY15_01890	COG0540	Belongs to the ATCase OTCase family
HPY15_01900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY15_01910	COG0564	pseudouridine synthase activity
HPY15_01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY15_01920	COG0525	valine-tRNA ligase activity
HPY15_01925	COG2927	DNA polymerase III (CHI subunit)
HPY15_01930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY15_01935	COG0795	lipopolysaccharide-transporting ATPase activity
HPY15_01940	COG0795	lipopolysaccharide-transporting ATPase activity
HPY15_01955	COG3437	response regulator, receiver
HPY15_02000	COG0066	3-isopropylmalate dehydratase activity
HPY15_02005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY15_02010	COG0473	3-isopropylmalate dehydrogenase activity
HPY15_02030	COG0583	DNA-binding transcription factor activity
HPY15_02035	COG1022	Amp-dependent synthetase and ligase
HPY15_02040	COG0028	Belongs to the TPP enzyme family
HPY15_02045	COG0440	acetolactate synthase activity
HPY15_02050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY15_02055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY15_02060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY15_02070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY15_02075	COG3079	Belongs to the UPF0149 family
HPY15_02080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY15_02085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY15_02100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY15_02110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY15_02115	COG1595	DNA-templated transcription, initiation
HPY15_02130	COG3086	response to oxidative stress
HPY15_02135	COG0481	GTPase activity
HPY15_02145	COG0571	ribonuclease III activity
HPY15_02150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY15_02155	COG1381	Involved in DNA repair and RecF pathway recombination
HPY15_02160	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY15_02165	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY15_02195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY15_02200	COG3956	TIGRFAM MazG family protein
HPY15_02205	COG0504	CTP synthase activity
HPY15_02210	COG0148	phosphopyruvate hydratase activity
HPY15_02220	COG3267	Type II secretory pathway component ExeA
HPY15_02220	COG3409	Peptidoglycan-binding domain 1 protein
HPY15_02230	COG4991	sh3 domain protein
HPY15_02235	COG0306	phosphate transporter
HPY15_02240	COG1392	Phosphate transport regulator
HPY15_02245	COG3025	triphosphatase activity
HPY15_02250	COG0840	transmembrane signaling receptor activity
HPY15_02255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY15_02260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY15_02260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY15_02265	COG1538	Outer membrane efflux protein
HPY15_02270	COG0494	nUDIX hydrolase
HPY15_02275	COG3151	Protein conserved in bacteria
HPY15_02285	COG3150	esterase
HPY15_02290	COG0187	DNA topoisomerase II activity
HPY15_02295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY15_02305	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY15_02310	COG0237	dephospho-CoA kinase activity
HPY15_02320	COG1459	type II secretion system
HPY15_02325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY15_02350	COG0716	FMN binding
HPY15_02355	COG4974	Belongs to the 'phage' integrase family
HPY15_02360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY15_02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY15_02370	COG0737	Belongs to the 5'-nucleotidase family
HPY15_02375	COG2186	Transcriptional regulator
HPY15_02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY15_02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY15_02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY15_02405	COG3116	cell division
HPY15_02410	COG0768	penicillin binding
HPY15_02415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY15_02420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY15_02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY15_02435	COG0772	Belongs to the SEDS family
HPY15_02445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY15_02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY15_02455	COG0849	cell division
HPY15_02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY15_02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY15_02475	COG0653	protein targeting
HPY15_02480	COG0494	nUDIX hydrolase
HPY15_02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY15_02495	COG0505	Belongs to the CarA family
HPY15_02500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY15_02520	COG0730	response to heat
HPY15_02525	COG0583	DNA-binding transcription factor activity
HPY15_02530	COG2860	membrane
HPY15_02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY15_02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY15_02555	COG0493	'glutamate synthase
HPY15_02560	COG0070	glutamate synthase
HPY15_02560	COG0069	glutamate synthase activity
HPY15_02560	COG0067	glutamate synthase
HPY15_02570	COG0070	glutamate synthase
HPY15_02570	COG0069	glutamate synthase activity
HPY15_02570	COG0067	glutamate synthase
HPY15_02575	COG1242	4 iron, 4 sulfur cluster binding
HPY15_02580	COG4251	negative regulation of phosphorylation
HPY15_02580	COG2203	Gaf domain
HPY15_02580	COG5001	Diguanylate cyclase
HPY15_02580	COG3706	GGDEF domain
HPY15_02585	COG5002	protein histidine kinase activity
HPY15_02585	COG0784	Response regulator, receiver
HPY15_02585	COG2198	Histidine kinase
HPY15_02590	COG0745	RESPONSE REGULATOR receiver
HPY15_02600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY15_02620	COG0083	homoserine kinase activity
HPY15_02625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY15_02630	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY15_02635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY15_02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY15_02655	COG1115	amino acid carrier protein
HPY15_02660	COG3022	response to hydroperoxide
HPY15_02670	COG0084	hydrolase, TatD family'
HPY15_02675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY15_02685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY15_02690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY15_02695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY15_02700	COG0813	purine-nucleoside phosphorylase activity
HPY15_02710	COG0560	Phosphoserine phosphatase
HPY15_02720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY15_02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY15_02730	COG1022	Amp-dependent synthetase and ligase
HPY15_02745	COG3250	beta-galactosidase activity
HPY15_02750	COG1609	Transcriptional regulator
HPY15_02755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY15_02770	COG0189	ligase activity
HPY15_02770	COG0569	domain protein
HPY15_02775	COG0456	acetyltransferase
HPY15_02785	COG2171	N-acyltransferase activity
HPY15_02790	COG3141	response to X-ray
HPY15_02805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY15_02825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY15_02825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY15_02835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY15_02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY15_02845	COG2166	iron-sulfur cluster assembly
HPY15_02850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY15_02855	COG0693	protein deglycase activity
HPY15_02860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY15_02875	COG1595	DNA-templated transcription, initiation
HPY15_02885	COG2211	Major facilitator Superfamily
HPY15_02890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY15_02900	COG2813	Specifically methylates the guanine in position
HPY15_02905	COG0271	Belongs to the BolA IbaG family
HPY15_02910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY15_02915	COG1805	sodium ion transport
HPY15_02920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY15_02925	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY15_02930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY15_02940	COG1477	protein flavinylation
HPY15_02960	COG3706	GGDEF domain
HPY15_02965	COG0733	neurotransmitter:sodium symporter activity
HPY15_02975	COG0189	ligase activity
HPY15_02980	COG4067	protein conserved in archaea
HPY15_02980	COG0189	ligase activity
HPY15_02985	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY15_02990	COG2252	PERMEase
HPY15_02995	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY15_03010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY15_03015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY15_03020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY15_03025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY15_03025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY15_03040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY15_03045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY15_03050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY15_03055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY15_03065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY15_03070	COG0024	Methionine aminopeptidase
HPY15_03075	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY15_03080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY15_03085	COG0528	UMP kinase activity
HPY15_03090	COG0233	cytoplasmic translational termination
HPY15_03095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY15_03100	COG0575	Belongs to the CDS family
HPY15_03105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY15_03110	COG0750	zinc metalloprotease
HPY15_03120	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY15_03125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY15_03130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY15_03135	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY15_03140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY15_03145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY15_03150	COG0587	DNA-directed DNA polymerase activity
HPY15_03155	COG0825	malonyl-CoA metabolic process
HPY15_03160	COG0037	tRNA processing
HPY15_03170	COG3479	Phenolic acid decarboxylase
HPY15_03175	COG0347	Belongs to the P(II) protein family
HPY15_03180	COG3021	interspecies interaction between organisms
HPY15_03185	COG1388	LysM domain
HPY15_03185	COG0741	lytic transglycosylase activity
HPY15_03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY15_03195	COG2226	methyltransferase
HPY15_03200	COG0328	RNA-DNA hybrid ribonuclease activity
HPY15_03215	COG1960	acyl-CoA dehydrogenase activity
HPY15_03220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY15_03225	COG0121	glutamine amidotransferase
HPY15_03230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY15_03235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY15_03240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY15_03245	COG3706	GGDEF domain
HPY15_03250	COG1187	pseudouridine synthase activity
HPY15_03255	COG2840	Smr protein MutS2
HPY15_03285	COG2217	Heavy metal translocating P-type atpase
HPY15_03285	COG2608	mercury ion transmembrane transporter activity
HPY15_03290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY15_03305	COG4774	siderophore transport
HPY15_03305	COG1629	transport
HPY15_03310	COG2375	cellular response to nickel ion
HPY15_03315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY15_03315	COG2226	methyltransferase
HPY15_03315	COG3433	isochorismatase activity
HPY15_03350	COG0835	chemotaxis
HPY15_03350	COG0784	Response regulator, receiver
HPY15_03355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY15_03360	COG1815	bacterial-type flagellum-dependent cell motility
HPY15_03375	COG1749	Flagellar hook protein flgE
HPY15_03380	COG4787	bacterial-type flagellum-dependent cell motility
HPY15_03390	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY15_03395	COG1706	bacterial-type flagellum-dependent cell motility
HPY15_03400	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY15_03400	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY15_03415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY15_03420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY15_03505	COG0012	GTP binding
HPY15_03510	COG0193	aminoacyl-tRNA hydrolase activity
HPY15_03515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY15_03520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY15_03525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY15_03530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY15_03535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY15_03540	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY15_03550	COG2912	Transglutaminase-like superfamily
HPY15_03555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY15_03560	COG0737	Belongs to the 5'-nucleotidase family
HPY15_03565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY15_03570	COG2233	PERMEase
HPY15_03600	COG1393	Belongs to the ArsC family
HPY15_03605	COG4783	chaperone-mediated protein folding
HPY15_03625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY15_03640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY15_03650	COG1876	peptidase activity
HPY15_03660	COG1393	Belongs to the ArsC family
HPY15_03680	COG2837	iron assimilation
HPY15_03685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY15_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY15_03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY15_03700	COG1334	flagellar protein FlaG
HPY15_03705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY15_03715	COG1516	flagellar protein fliS
HPY15_03725	COG4191	Histidine kinase
HPY15_03735	COG1677	Flagellar hook-basal body complex protein FliE
HPY15_03745	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY15_03750	COG1317	bacterial-type flagellum organization
HPY15_03775	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY15_03800	COG1987	bacterial-type flagellum assembly
HPY15_03805	COG1684	flagellar biosynthetic protein fliR
HPY15_03815	COG2840	Smr protein MutS2
HPY15_03820	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY15_03825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY15_03830	COG2860	membrane
HPY15_03835	COG3101	peptidyl-lysine hydroxylation
HPY15_03845	COG0431	NADPH-dependent FMN reductase
HPY15_03850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY15_03850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY15_03855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY15_03860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY15_03865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY15_03870	COG0735	belongs to the Fur family
HPY15_03880	COG0583	DNA-binding transcription factor activity
HPY15_03890	COG1346	cytolysis
HPY15_03905	COG0596	Alpha beta hydrolase
HPY15_03910	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY15_03915	COG0033	Phosphoglucomutase
HPY15_03925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY15_03930	COG0372	Belongs to the citrate synthase family
HPY15_03935	COG2009	succinate dehydrogenase
HPY15_03940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY15_03945	COG1053	succinate dehydrogenase
HPY15_03955	COG0567	Dehydrogenase, E1 component
HPY15_03960	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY15_03965	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY15_03975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY15_03980	COG1121	(ABC) transporter
HPY15_03985	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY15_03990	COG4977	sequence-specific DNA binding
HPY15_03995	COG1918	ferrous iron import across plasma membrane
HPY15_04015	COG0018	arginyl-trna synthetase
HPY15_04025	COG1025	Belongs to the peptidase M16 family
HPY15_04030	COG2062	phosphohistidine phosphatase, SixA
HPY15_04060	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY15_04065	COG0643	Histidine kinase
HPY15_04065	COG0784	Response regulator, receiver
HPY15_04065	COG2198	Histidine kinase
HPY15_04070	COG2201	protein-glutamate methylesterase activity
HPY15_04075	COG1192	Involved in chromosome partitioning
HPY15_04085	COG0835	chemotaxis
HPY15_04095	COG4133	protoheme IX ABC transporter activity
HPY15_04100	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY15_04105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY15_04115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY15_04120	COG1138	Cytochrome C-type biogenesis protein
HPY15_04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY15_04130	COG4235	cytochrome complex assembly
HPY15_04130	COG3088	subunit of a heme lyase
HPY15_04140	COG2853	Lipoprotein
HPY15_04160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY15_04165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY15_04170	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY15_04185	COG3083	sulfuric ester hydrolase activity
HPY15_04190	COG3082	Protein of unknown function (DUF1414)
HPY15_04195	COG3081	Nucleoid-associated protein
HPY15_04205	COG1757	Na H antiporter
HPY15_04210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY15_04215	COG2095	MarC family integral membrane protein
HPY15_04220	COG1454	alcohol dehydrogenase
HPY15_04220	COG1012	belongs to the aldehyde dehydrogenase family
HPY15_04230	COG0659	secondary active sulfate transmembrane transporter activity
HPY15_04235	COG1530	ribonuclease E activity
HPY15_04240	COG0564	pseudouridine synthase activity
HPY15_04245	COG0424	maF-like protein
HPY15_04250	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY15_04255	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY15_04260	COG0416	fatty acid biosynthetic process
HPY15_04265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY15_04275	COG1028	Short-chain dehydrogenase reductase Sdr
HPY15_04280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY15_04285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY15_04290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY15_04295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY15_04300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY15_04310	COG0084	hydrolase, TatD family'
HPY15_04315	COG1263	PTS System
HPY15_04315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY15_04325	COG0733	neurotransmitter:sodium symporter activity
HPY15_04340	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY15_04350	COG1940	carbohydrate kinase activity
HPY15_04355	COG0784	Response regulator, receiver
HPY15_04355	COG0835	chemotaxis
HPY15_04370	COG2226	methyltransferase
HPY15_04380	COG0676	glucose-6-phosphate 1-epimerase activity
HPY15_04385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY15_04390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY15_04400	COG3139	Protein of unknown function (DUF1315)
HPY15_04405	COG0252	asparaginase activity
HPY15_04410	COG0616	signal peptide processing
HPY15_04415	COG1902	pentaerythritol trinitrate reductase activity
HPY15_04415	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY15_04420	COG0788	formyltetrahydrofolate deformylase activity
HPY15_04430	COG1199	ATP-dependent helicase activity
HPY15_04435	COG1214	PFAM Peptidase M22, glycoprotease
HPY15_04450	COG0596	Alpha beta hydrolase
HPY15_04455	COG0318	PFAM AMP-dependent synthetase and ligase
HPY15_04460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY15_04480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY15_04485	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY15_04490	COG0436	Aminotransferase
HPY15_04495	COG1169	isochorismate synthase
HPY15_04500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY15_04505	COG0596	Alpha beta hydrolase
HPY15_04525	COG3135	benzoate transporter
HPY15_04550	COG3015	lipoprotein NlpE involved in copper resistance
HPY15_04555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY15_04560	COG2894	cell division
HPY15_04565	COG0850	regulation of cytokinetic process
HPY15_04570	COG3100	YcgL domain-containing protein
HPY15_04575	COG2951	lytic endotransglycosylase activity
HPY15_04585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY15_04590	COG3469	chitinase activity
HPY15_04590	COG3325	Belongs to the glycosyl hydrolase 18 family
HPY15_04595	COG3005	denitrification pathway
HPY15_04600	COG0243	molybdopterin cofactor binding
HPY15_04615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY15_04625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY15_04660	COG4589	Belongs to the CDS family
HPY15_04670	COG3300	MHYT domain
HPY15_04670	COG5001	Diguanylate cyclase
HPY15_04680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY15_04685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY15_04690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY15_04695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY15_04705	COG4191	Histidine kinase
HPY15_04715	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY15_04725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY15_04730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY15_04735	COG0776	regulation of translation
HPY15_04740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY15_04745	COG1555	photosystem II stabilization
HPY15_04750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY15_04755	COG0539	negative regulation of cytoplasmic translation
HPY15_04760	COG0776	regulation of translation
HPY15_04765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY15_04770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY15_04790	COG0583	DNA-binding transcription factor activity
HPY15_04800	COG0686	Belongs to the AlaDH PNT family
HPY15_04810	COG1674	ftsk spoiiie
HPY15_04815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY15_04820	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY15_04825	COG2186	Transcriptional regulator
HPY15_04840	COG0537	adenosine 5'-monophosphoramidase activity
HPY15_04865	COG3150	esterase
HPY15_04870	COG1252	NADH dehydrogenase
HPY15_04890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY15_04900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY15_04905	COG1136	(ABC) transporter
HPY15_04910	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY15_04920	COG2333	competence protein COMEC
HPY15_04920	COG0658	competence protein
HPY15_04925	COG1132	(ABC) transporter
HPY15_04930	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY15_04935	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY15_04940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY15_04945	COG2719	SpoVR family
HPY15_04950	COG2718	Belongs to the UPF0229 family
HPY15_04955	COG2766	serine protein kinase
HPY15_04960	COG3013	Belongs to the UPF0304 family
HPY15_04970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY15_04975	COG0840	transmembrane signaling receptor activity
HPY15_04985	COG1882	Formate acetyltransferase
HPY15_05010	COG4160	amino acid transport
HPY15_05015	COG0708	Exodeoxyribonuclease III
HPY15_05020	COG0840	transmembrane signaling receptor activity
HPY15_05030	COG3923	Primosomal replication protein n
HPY15_05035	COG0730	response to heat
HPY15_05040	COG1199	ATP-dependent helicase activity
HPY15_05045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY15_05050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY15_05055	COG3012	SEC-C Motif Domain Protein
HPY15_05060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY15_05065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY15_05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY15_05075	COG0215	cysteine-tRNA ligase activity
HPY15_05080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY15_05085	COG0632	four-way junction helicase activity
HPY15_05095	COG1271	oxidase subunit
HPY15_05100	COG1294	oxidase, subunit
HPY15_05105	COG4890	Cyd operon protein YbgT
HPY15_05110	COG3790	cyd operon protein YbgE
HPY15_05115	COG0824	Thioesterase
HPY15_05120	COG0811	peptide transport
HPY15_05135	COG0823	Involved in the tonB-independent uptake of proteins
HPY15_05140	COG2885	chlorophyll binding
HPY15_05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY15_05160	COG5002	protein histidine kinase activity
HPY15_05160	COG0784	Response regulator, receiver
HPY15_05170	COG1012	belongs to the aldehyde dehydrogenase family
HPY15_05175	COG3284	Transcriptional regulator
HPY15_05180	COG4628	conserved protein (DUF2132)
HPY15_05190	COG0415	Belongs to the DNA photolyase family
HPY15_05200	COG5001	Diguanylate cyclase
HPY15_05215	COG1401	restriction endodeoxyribonuclease activity
HPY15_05250	COG4409	exo-alpha-(2->6)-sialidase activity
HPY15_05255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY15_05260	COG1940	carbohydrate kinase activity
HPY15_05270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY15_05275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY15_05280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY15_05285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPY15_05290	COG1737	Transcriptional regulator
HPY15_05295	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY15_05300	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY15_05310	COG5492	domain, Protein
HPY15_05310	COG4932	domain protein
HPY15_05335	COG0596	Alpha beta hydrolase
HPY15_05345	COG3064	Membrane
HPY15_05450	COG4789	Type iii secretion
HPY15_05455	COG4792	protein secretion
HPY15_05485	COG3710	Transcriptional regulator
HPY15_05500	COG4790	Type iii secretion
HPY15_05590	COG0582	viral genome integration into host DNA
HPY15_05605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY15_05615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY15_05615	COG3008	intermembrane lipid transfer
HPY15_05620	COG2995	paraquat-inducible protein a
HPY15_05625	COG1309	transcriptional regulator
HPY15_05630	COG1012	belongs to the aldehyde dehydrogenase family
HPY15_05650	COG1960	acyl-CoA dehydrogenase activity
HPY15_05655	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY15_05660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY15_05670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY15_05685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY15_05690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY15_05695	COG0297	glycogen (starch) synthase activity
HPY15_05715	COG3070	regulator of competence-specific genes
HPY15_05720	COG1609	Transcriptional regulator
HPY15_05725	COG3381	protein complex oligomerization
HPY15_05730	COG0745	RESPONSE REGULATOR receiver
HPY15_05735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY15_05740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY15_05745	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY15_05750	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY15_05765	COG1280	lysine exporter protein (LysE YggA)
HPY15_05770	COG1032	radical SAM domain protein
HPY15_05775	COG5001	Diguanylate cyclase
HPY15_05780	COG0612	Peptidase, M16
HPY15_05795	COG0583	DNA-binding transcription factor activity
HPY15_05800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY15_05810	COG2350	Protein conserved in bacteria
HPY15_05815	COG1607	acyl-coa hydrolase
HPY15_05830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY15_05835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY15_05845	COG2116	formate transmembrane transporter activity
HPY15_05850	COG4459	periplasmic nitrate reductase
HPY15_05855	COG3005	denitrification pathway
HPY15_05860	COG0243	molybdopterin cofactor binding
HPY15_05875	COG1227	inorganic diphosphatase activity
HPY15_05890	COG4172	Belongs to the ABC transporter superfamily
HPY15_05905	COG4168	peptide transport system, permease
HPY15_05915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY15_05920	COG1842	Phage shock protein A
HPY15_05935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY15_05950	COG2818	Glycosylase
HPY15_05955	COG0626	cystathionine gamma-synthase activity
HPY15_05965	COG0733	neurotransmitter:sodium symporter activity
HPY15_05970	COG0564	pseudouridine synthase activity
HPY15_05975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY15_05980	COG4136	ATPase activity
HPY15_05985	COG4135	transport system, permease component
HPY15_05990	COG4134	Bacterial extracellular solute-binding protein
HPY15_06000	COG3313	Fe-S protein
HPY15_06010	COG0842	Transport permease protein
HPY15_06015	COG1131	(ABC) transporter
HPY15_06020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY15_06025	COG0814	amino acid
HPY15_06035	COG2239	Acts as a magnesium transporter
HPY15_06040	COG0784	Response regulator, receiver
HPY15_06040	COG2205	protein histidine kinase activity
HPY15_06055	COG4934	collagen metabolic process
HPY15_06075	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HPY15_06090	COG0840	transmembrane signaling receptor activity
HPY15_06100	COG3706	GGDEF domain
HPY15_06100	COG4251	negative regulation of phosphorylation
HPY15_06100	COG2203	Gaf domain
HPY15_06100	COG5001	Diguanylate cyclase
HPY15_06105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY15_06125	COG1061	Type III restriction enzyme res subunit
HPY15_06130	COG1187	pseudouridine synthase activity
HPY15_06135	COG2814	Major facilitator Superfamily
HPY15_06145	COG0702	epimerase
HPY15_06150	COG0534	Mate efflux family protein
HPY15_06155	COG4181	ATPase activity
HPY15_06170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY15_06180	COG1748	Saccharopine dehydrogenase
HPY15_06195	COG1538	Outer membrane efflux protein
HPY15_06215	COG0583	DNA-binding transcription factor activity
HPY15_06225	COG1451	nucleotide metabolic process
HPY15_06240	COG3063	Type IV pilus biogenesis stability protein PilW
HPY15_06245	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY15_06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY15_06280	COG3290	protein histidine kinase activity
HPY15_06285	COG4565	transcriptional regulatory protein
HPY15_06295	COG0835	chemotaxis
HPY15_06295	COG0784	Response regulator, receiver
HPY15_06335	COG0477	Major facilitator Superfamily
HPY15_06340	COG1085	galactose-1-phosphate uridylyltransferase
HPY15_06345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY15_06350	COG2017	converts alpha-aldose to the beta-anomer
HPY15_06355	COG3706	GGDEF domain
HPY15_06360	COG2199	diguanylate cyclase activity
HPY15_06360	COG2200	EAL domain
HPY15_06375	COG3527	Alpha-acetolactate decarboxylase
HPY15_06385	COG0346	lactoylglutathione lyase activity
HPY15_06395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY15_06400	COG0693	protein deglycase activity
HPY15_06420	COG0753	catalase activity
HPY15_06440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY15_06490	COG1271	oxidase subunit
HPY15_06495	COG1294	oxidase, subunit
HPY15_06500	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY15_06500	COG1136	(ABC) transporter
HPY15_06505	COG0577	efflux transmembrane transporter activity
HPY15_06505	COG1136	(ABC) transporter
HPY15_06510	COG0577	efflux transmembrane transporter activity
HPY15_06510	COG1136	(ABC) transporter
HPY15_06540	COG2723	6-phospho-beta-galactosidase activity
HPY15_06545	COG1609	Transcriptional regulator
HPY15_06550	COG0251	oxidation-reduction process
HPY15_06555	COG2731	YhcH YjgK YiaL family protein
HPY15_06560	COG0584	glycerophosphoryl diester phosphodiesterase
HPY15_06565	COG1349	DNA-binding transcription factor activity
HPY15_06570	COG3842	ATPase activity
HPY15_06575	COG0395	ABC-type sugar transport system, permease component
HPY15_06580	COG1175	transmembrane transport
HPY15_06595	COG0811	peptide transport
HPY15_06600	COG0811	peptide transport
HPY15_06605	COG0848	biopolymer transport protein
HPY15_06610	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY15_06620	COG1793	dna ligase
HPY15_06630	COG0534	Mate efflux family protein
HPY15_06640	COG3001	Fructosamine kinase
HPY15_06650	COG0791	NLP P60 protein
HPY15_06655	COG0840	transmembrane signaling receptor activity
HPY15_06670	COG1940	carbohydrate kinase activity
HPY15_06680	COG0303	'Molybdopterin
HPY15_06685	COG0746	molybdenum cofactor guanylyltransferase activity
HPY15_06690	COG3842	ATPase activity
HPY15_06695	COG4662	Binding-protein-dependent transport system inner membrane component
HPY15_06705	COG2204	response regulator
HPY15_06710	COG3852	Histidine kinase
HPY15_06715	COG0488	(ABC) transporter
HPY15_06720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY15_06750	COG0243	molybdopterin cofactor binding
HPY15_06750	COG3383	formate dehydrogenase (NAD+) activity
HPY15_06755	COG0437	4 iron, 4 sulfur cluster binding
HPY15_06770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY15_06775	COG1666	GTP binding
HPY15_06780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY15_06795	COG2996	Protein conserved in bacteria
HPY15_06805	COG3008	intermembrane lipid transfer
HPY15_06810	COG2995	paraquat-inducible protein a
HPY15_06815	COG1132	(ABC) transporter
HPY15_06820	COG1956	GAF domain-containing protein
HPY15_06825	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY15_06840	COG0308	aminopeptidase N
HPY15_06855	COG0167	dihydroorotate dehydrogenase activity
HPY15_06865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY15_06865	COG0116	Belongs to the methyltransferase superfamily
HPY15_06890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY15_06895	COG1067	ATP-dependent peptidase activity
HPY15_06900	COG3120	sequence-specific DNA binding
HPY15_06930	COG3422	double-strand break repair
HPY15_06985	COG3064	Membrane
HPY15_06985	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY15_06985	COG1073	alpha beta
HPY15_06990	COG2994	toxin metabolic process
HPY15_07015	COG0784	Response regulator, receiver
HPY15_07015	COG2205	protein histidine kinase activity
HPY15_07030	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY15_07045	COG2010	Cytochrome c
HPY15_07055	COG2217	Heavy metal translocating P-type atpase
HPY15_07070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY15_07075	COG0589	response to stress
HPY15_07080	COG0037	tRNA processing
HPY15_07100	COG3842	ATPase activity
HPY15_07110	COG1177	transmembrane transport
HPY15_07120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY15_07130	COG1115	amino acid carrier protein
HPY15_07135	COG1280	lysine exporter protein (LysE YggA)
HPY15_07155	COG3501	Rhs element vgr protein
HPY15_07165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY15_07170	COG0840	transmembrane signaling receptor activity
HPY15_07175	COG2814	Major facilitator Superfamily
HPY15_07180	COG1566	PFAM secretion protein HlyD family protein
HPY15_07185	COG1538	Outer membrane efflux protein
HPY15_07195	COG0513	Belongs to the DEAD box helicase family
HPY15_07205	COG0840	transmembrane signaling receptor activity
HPY15_07210	COG0840	transmembrane signaling receptor activity
HPY15_07210	COG3290	protein histidine kinase activity
HPY15_07215	COG0835	chemotaxis
HPY15_07220	COG2201	protein-glutamate methylesterase activity
HPY15_07230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY15_07235	COG0784	Response regulator, receiver
HPY15_07235	COG0643	Histidine kinase
HPY15_07235	COG2198	Histidine kinase
HPY15_07240	COG0643	Histidine kinase
HPY15_07240	COG2198	Histidine kinase
HPY15_07250	COG0745	RESPONSE REGULATOR receiver
HPY15_07265	COG0415	Belongs to the DNA photolyase family
HPY15_07270	COG0477	Major facilitator Superfamily
HPY15_07275	COG0583	DNA-binding transcription factor activity
HPY15_07285	COG0402	S-adenosylhomocysteine deaminase activity
HPY15_07290	COG0095	Lipoate-protein ligase
HPY15_07295	COG0443	Heat shock 70 kDa protein
HPY15_07305	COG1643	Atp-dependent helicase
HPY15_07340	COG0443	Heat shock 70 kDa protein
HPY15_07345	COG3706	GGDEF domain
HPY15_07375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY15_07380	COG0602	queuosine metabolic process
HPY15_07385	COG0561	phosphatase activity
HPY15_07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY15_07400	COG4597	amino acid ABC transporter
HPY15_07405	COG0765	amino acid transport
HPY15_07410	COG1126	abc transporter atp-binding protein
HPY15_07415	COG0670	Belongs to the BI1 family
HPY15_07420	COG2920	part of a sulfur-relay system
HPY15_07425	COG1254	Belongs to the acylphosphatase family
HPY15_07430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY15_07435	COG3706	GGDEF domain
HPY15_07445	COG3850	Histidine kinase
HPY15_07445	COG2205	protein histidine kinase activity
HPY15_07445	COG4999	Histidine kinase
HPY15_07445	COG3437	response regulator, receiver
HPY15_07450	COG3437	response regulator, receiver
HPY15_07455	COG0625	glutathione transferase activity
HPY15_07465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY15_07475	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY15_07505	COG0372	Belongs to the citrate synthase family
HPY15_07510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY15_07550	COG1566	PFAM secretion protein HlyD family protein
HPY15_07570	COG1129	ABC transporter
HPY15_07595	COG0745	RESPONSE REGULATOR receiver
HPY15_07600	COG5002	protein histidine kinase activity
HPY15_07605	COG3713	MltA-interacting MipA family protein
HPY15_07610	COG2990	Protein conserved in bacteria
HPY15_07620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY15_07620	COG4191	Histidine kinase
HPY15_07625	COG0471	metal ion transport
HPY15_07635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY15_07650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY15_07660	COG3768	UPF0283 membrane protein
HPY15_07665	COG3106	COG3106 Predicted ATPase
HPY15_07680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY15_07685	COG0494	nUDIX hydrolase
HPY15_07690	COG0814	amino acid
HPY15_07695	COG1760	l-serine dehydratase
HPY15_07700	COG0720	synthase
HPY15_07705	COG0840	transmembrane signaling receptor activity
HPY15_07710	COG0017	Asparaginyl-tRNA synthetase
HPY15_07715	COG0351	phosphomethylpyrimidine kinase
HPY15_07720	COG2770	Histidine kinase
HPY15_07720	COG3437	response regulator, receiver
HPY15_07725	COG1448	Aminotransferase
HPY15_07750	COG0840	transmembrane signaling receptor activity
HPY15_07755	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY15_07760	COG2943	transferase activity, transferring hexosyl groups
HPY15_07765	COG1609	Transcriptional regulator
HPY15_07770	COG3394	polysaccharide catabolic process
HPY15_07775	COG1486	melibiose metabolic process
HPY15_07780	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPY15_07790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPY15_07795	COG0726	polysaccharide deacetylase
HPY15_07800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY15_07805	COG1846	Transcriptional regulator
HPY15_07830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY15_07845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY15_07850	COG3108	Peptidase M15
HPY15_07880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY15_07890	COG2814	Major facilitator Superfamily
HPY15_07910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY15_07915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY15_07920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY15_07965	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY15_07970	COG4139	cobalamin transport
HPY15_07975	COG2988	succinylglutamate desuccinylase activity
HPY15_07990	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY15_07995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY15_08000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY15_08010	COG2925	Exonuclease
HPY15_08015	COG1380	Effector of murein hydrolase LrgA
HPY15_08020	COG1346	cytolysis
HPY15_08050	COG0776	regulation of translation
HPY15_08055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY15_08055	COG0072	phenylalanine-tRNA ligase activity
HPY15_08060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY15_08110	COG0322	excinuclease ABC activity
HPY15_08115	COG2197	response regulator
HPY15_08120	COG0417	DNA replication proofreading
HPY15_08125	COG5001	Diguanylate cyclase
HPY15_08135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY15_08140	COG3099	Belongs to the UPF0263 family
HPY15_08155	COG1228	amidohydrolase
HPY15_08160	COG0010	Belongs to the arginase family
HPY15_08165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY15_08170	COG2986	histidine ammonia-lyase
HPY15_08190	COG0277	FAD linked oxidase domain protein
HPY15_08190	COG0247	lactate metabolic process
HPY15_08205	COG2885	chlorophyll binding
HPY15_08225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY15_08235	COG0281	malic enzyme
HPY15_08245	COG2949	membrane
HPY15_08250	COG3706	GGDEF domain
HPY15_08255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY15_08265	COG0492	ferredoxin-NADP+ reductase activity
HPY15_08270	COG4988	ABC transporter
HPY15_08275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY15_08280	COG1187	pseudouridine synthase activity
HPY15_08285	COG0009	L-threonylcarbamoyladenylate synthase
HPY15_08290	COG0613	PHP domain protein
HPY15_08300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY15_08305	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY15_08310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY15_08315	COG0135	phosphoribosylanthranilate isomerase activity
HPY15_08315	COG0134	indole-3-glycerol-phosphate synthase activity
HPY15_08320	COG0133	tryptophan synthase activity
HPY15_08325	COG0159	tryptophan synthase activity
HPY15_08335	COG1435	thymidine kinase activity
HPY15_08340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY15_08345	COG1801	Protein of unknown function DUF72
HPY15_08350	COG4106	trans-aconitate 2-methyltransferase activity
HPY15_08355	COG0500	methyltransferase
HPY15_08360	COG0189	ligase activity
HPY15_08360	COG4067	protein conserved in archaea
HPY15_08375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY15_08385	COG3852	Histidine kinase
HPY15_08400	COG3070	regulator of competence-specific genes
HPY15_08410	COG2431	L-lysine efflux transmembrane transporter activity
HPY15_08420	COG0076	glutamate decarboxylase activity
HPY15_08425	COG1737	Transcriptional regulator
HPY15_08430	COG1012	belongs to the aldehyde dehydrogenase family
HPY15_08430	COG1454	alcohol dehydrogenase
HPY15_08435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY15_08440	COG3273	potassium ion transport
HPY15_08440	COG2985	domain, Protein
HPY15_08445	COG0542	response to heat
HPY15_08450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY15_08455	COG1278	Cold shock
HPY15_08465	COG1187	pseudouridine synthase activity
HPY15_08470	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY15_08470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY15_08475	COG0107	imidazoleglycerol-phosphate synthase activity
HPY15_08480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY15_08485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY15_08490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY15_08490	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY15_08495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY15_08500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY15_08505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY15_08510	COG1757	Na H antiporter
HPY15_08515	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY15_08520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY15_08525	COG0482	sulfurtransferase activity
HPY15_08530	COG2915	High frequency lysogenization protein hflD homolog
HPY15_08535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY15_08545	COG2268	Band 7 protein
HPY15_08555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY15_08570	COG0300	oxidoreductase activity
HPY15_08580	COG0501	Belongs to the peptidase M48B family
HPY15_08590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY15_08595	COG2226	methyltransferase
HPY15_08600	COG0156	8-amino-7-oxononanoate synthase activity
HPY15_08605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY15_08610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY15_08615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY15_08620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY15_08625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY15_08630	COG0653	protein targeting
HPY15_08635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY15_08640	COG3706	GGDEF domain
HPY15_08650	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY15_08660	COG4628	conserved protein (DUF2132)
HPY15_08665	COG3092	negative regulation of chromosome organization
HPY15_08670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY15_08675	COG0857	belongs to the CobB CobQ family
HPY15_08675	COG0280	phosphate acetyltransferase
HPY15_08680	COG0435	Glutathione S-transferase
HPY15_08685	COG4608	Belongs to the ABC transporter superfamily
HPY15_08690	COG0444	Belongs to the ABC transporter superfamily
HPY15_08695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY15_08700	COG0601	transmembrane transport
HPY15_08720	COG2204	response regulator
HPY15_08725	COG5001	Diguanylate cyclase
HPY15_08725	COG3300	MHYT domain
HPY15_08730	COG4191	Histidine kinase
HPY15_08735	COG5002	protein histidine kinase activity
HPY15_08745	COG2201	protein-glutamate methylesterase activity
HPY15_08760	COG0009	L-threonylcarbamoyladenylate synthase
HPY15_08775	COG1881	PFAM PEBP family protein
HPY15_08800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY15_08805	COG0640	Transcriptional regulator
HPY15_08815	COG3706	GGDEF domain
HPY15_08835	COG1946	Acyl-CoA thioesterase
HPY15_08840	COG1522	sequence-specific DNA binding
HPY15_08850	COG0616	signal peptide processing
HPY15_08855	COG1028	Short-chain dehydrogenase reductase Sdr
HPY15_08865	COG2983	Belongs to the UPF0260 family
HPY15_08875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY15_08880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY15_08885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY15_08890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY15_08895	COG2832	Protein of unknown function (DUF454)
HPY15_08900	COG0745	RESPONSE REGULATOR receiver
HPY15_08905	COG0583	DNA-binding transcription factor activity
HPY15_08910	COG0778	Nitroreductase
HPY15_08915	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY15_08915	COG1024	Enoyl-CoA hydratase
HPY15_08920	COG0183	Belongs to the thiolase family
HPY15_08935	COG2067	long-chain fatty acid transport protein
HPY15_08945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY15_08950	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY15_08955	COG2982	Protein involved in outer membrane biogenesis
HPY15_08960	COG0572	uridine kinase
HPY15_08965	COG0489	protein tyrosine kinase activity
HPY15_08970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY15_08970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY15_08980	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY15_08990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY15_08990	COG0517	IMP dehydrogenase activity
HPY15_08990	COG0617	tRNA 3'-terminal CCA addition
HPY15_08995	COG2199	diguanylate cyclase activity
HPY15_09000	COG0314	molybdopterin synthase activity
HPY15_09005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY15_09010	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY15_09015	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY15_09020	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY15_09025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY15_09030	COG2198	Histidine kinase
HPY15_09035	COG2204	response regulator
HPY15_09040	COG0556	nucleotide-excision repair
HPY15_09050	COG4657	Part of a membrane complex involved in electron transport
HPY15_09055	COG2878	Part of a membrane complex involved in electron transport
HPY15_09060	COG4656	Part of a membrane complex involved in electron transport
HPY15_09075	COG4660	Part of a membrane complex involved in electron transport
HPY15_09080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY15_09085	COG0346	lactoylglutathione lyase activity
HPY15_09100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY15_09105	COG2056	Na+-H+ antiporter family
HPY15_09110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY15_09115	COG1286	toxin biosynthetic process
HPY15_09120	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY15_09125	COG0285	dihydrofolate synthase activity
HPY15_09130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY15_09135	COG0101	tRNA pseudouridine synthase activity
HPY15_09150	COG1263	PTS System
HPY15_09150	COG2190	(PTS) system
HPY15_09150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY15_09155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY15_09160	COG1940	carbohydrate kinase activity
HPY15_09160	COG1846	Transcriptional regulator
HPY15_09165	COG4651	solute:proton antiporter activity
HPY15_09165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY15_09170	COG0367	asparagine synthase
HPY15_09185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY15_09190	COG0563	adenylate kinase activity
HPY15_09195	COG0326	Molecular chaperone. Has ATPase activity
HPY15_09200	COG3710	Transcriptional regulator
HPY15_09215	COG0622	Phosphoesterase
HPY15_09220	COG1090	epimerase
HPY15_09225	COG0300	oxidoreductase activity
HPY15_09230	COG3118	belongs to the thioredoxin family
HPY15_09235	COG0330	HflC and HflK could
HPY15_09240	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY15_09245	COG0789	Transcriptional regulator
HPY15_09250	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY15_09260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY15_09265	COG3115	cell septum assembly
HPY15_09270	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY15_09275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY15_09280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY15_09290	COG2190	(PTS) system
HPY15_09295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY15_09300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY15_09305	COG1702	phosphate starvation-inducible protein PhoH
HPY15_09310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY15_09315	COG4535	Mg2 and Co2 transporter CorC
HPY15_09320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY15_09325	COG2888	peptidyl-tyrosine sulfation
HPY15_09330	COG0495	leucyl-tRNA aminoacylation
HPY15_09335	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY15_09340	COG1466	dna polymerase III delta subunit
HPY15_09345	COG0799	negative regulation of ribosome biogenesis
HPY15_09350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY15_09355	COG0768	penicillin binding
HPY15_09360	COG0772	Belongs to the SEDS family
HPY15_09365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY15_09370	COG1686	Belongs to the peptidase S11 family
HPY15_09375	COG2921	Belongs to the UPF0250 family
HPY15_09380	COG0321	lipoyl(octanoyl) transferase activity
HPY15_09385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY15_09395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY15_09420	COG1596	polysaccharide export
HPY15_09430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY15_09460	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY15_09470	COG0438	transferase activity, transferring glycosyl groups
HPY15_09480	COG0297	glycogen (starch) synthase activity
HPY15_09500	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY15_09505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY15_09510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY15_09515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY15_09545	COG0366	Alpha amylase catalytic
HPY15_09550	COG1263	PTS System
HPY15_09550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY15_09555	COG1609	Transcriptional regulator
HPY15_09560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY15_09565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY15_09570	COG2011	ABC-type metal ion transport system permease component
HPY15_09575	COG1464	Belongs to the NlpA lipoprotein family
HPY15_09580	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY15_09590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY15_09590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY15_09600	COG3706	GGDEF domain
HPY15_09605	COG1611	Belongs to the LOG family
HPY15_09610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY15_09615	COG2363	Small membrane protein
HPY15_09620	COG0583	DNA-binding transcription factor activity
HPY15_09625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY15_09625	COG0301	tRNA thio-modification
HPY15_09635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY15_09640	COG1722	exodeoxyribonuclease VII activity
HPY15_09645	COG0142	geranyltranstransferase activity
HPY15_09650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY15_09655	COG0564	pseudouridine synthase activity
HPY15_09660	COG3098	single-species biofilm formation
HPY15_09675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY15_09685	COG1671	Belongs to the UPF0178 family
HPY15_09690	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY15_09695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY15_09700	COG0254	rRNA binding
HPY15_09705	COG1720	tRNA m6t6A37 methyltransferase activity
HPY15_09710	COG0442	prolyl-tRNA aminoacylation
HPY15_09730	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY15_09730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY15_09740	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY15_09750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY15_09770	COG4968	Prepilin-type N-terminal cleavage methylation domain
HPY15_09780	COG0484	heat shock protein binding
HPY15_09785	COG0443	Heat shock 70 kDa protein
HPY15_09790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY15_09795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY15_09800	COG0497	DNA recombination
HPY15_09805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY15_09810	COG2914	Belongs to the UPF0125 (RnfH) family
HPY15_09815	COG2867	negative regulation of translational initiation
HPY15_09820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY15_09900	COG0328	RNA-DNA hybrid ribonuclease activity
HPY15_09945	COG1396	sequence-specific DNA binding
HPY15_09960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPY15_09965	COG0732	type I restriction modification DNA specificity domain
HPY15_09970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPY15_09985	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY15_09990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY15_09995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY15_10015	COG3051	citrate lyase alpha subunit
HPY15_10020	COG2301	Belongs to the HpcH HpaI aldolase family
HPY15_10025	COG3052	prosthetic group binding
HPY15_10030	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY15_10040	COG3630	sodium ion export across plasma membrane
HPY15_10045	COG0511	ligase activity, forming carbon-carbon bonds
HPY15_10045	COG5016	pyruvate
HPY15_10050	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY15_10060	COG4565	transcriptional regulatory protein
HPY15_10085	COG1115	amino acid carrier protein
HPY15_10090	COG2977	Belongs to the P-Pant transferase superfamily
HPY15_10095	COG1120	ATPase activity
HPY15_10100	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY15_10105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY15_10110	COG4592	Periplasmic binding protein
HPY15_10120	COG1028	Short-chain dehydrogenase reductase Sdr
HPY15_10125	COG1169	isochorismate synthase
HPY15_10130	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY15_10135	COG3433	isochorismatase activity
HPY15_10135	COG1535	isochorismatase
HPY15_10140	COG1584	GPR1 FUN34 yaaH family protein
HPY15_10150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY15_10150	COG0519	Catalyzes the synthesis of GMP from XMP
HPY15_10155	COG0516	GMP reductase activity
HPY15_10155	COG0517	IMP dehydrogenase activity
HPY15_10160	COG1570	exodeoxyribonuclease VII activity
HPY15_10175	COG1160	GTP binding
HPY15_10180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY15_10185	COG2976	Protein conserved in bacteria
HPY15_10190	COG0124	histidyl-tRNA synthetase
HPY15_10195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY15_10200	COG1426	Protein conserved in bacteria
HPY15_10210	COG0105	UTP biosynthetic process
HPY15_10215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY15_10220	COG2975	iron-sulfur cluster assembly
HPY15_10225	COG0633	Ferredoxin
HPY15_10245	COG0822	iron-sulfur transferase activity
HPY15_10250	COG1104	cysteine desulfurase activity
HPY15_10255	COG1959	2 iron, 2 sulfur cluster binding
HPY15_10265	COG0483	inositol monophosphate 1-phosphatase activity
HPY15_10270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY15_10275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY15_10280	COG1862	Preprotein translocase
HPY15_10290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY15_10295	COG0517	IMP dehydrogenase activity
HPY15_10305	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY15_10310	COG0583	DNA-binding transcription factor activity
HPY15_10315	COG0450	alkyl hydroperoxide reductase
HPY15_10320	COG3142	Participates in the control of copper homeostasis
HPY15_10335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY15_10340	COG0581	inorganic phosphate transmembrane transporter activity
HPY15_10350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY15_10355	COG0248	Ppx GppA phosphatase
HPY15_10365	COG5002	protein histidine kinase activity
HPY15_10370	COG0745	RESPONSE REGULATOR receiver
HPY15_10385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY15_10430	COG0542	response to heat
HPY15_10440	COG0564	pseudouridine synthase activity
HPY15_10445	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY15_10450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY15_10455	COG0077	Prephenate dehydratase
HPY15_10455	COG1605	Chorismate mutase
HPY15_10460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY15_10465	COG5001	Diguanylate cyclase
HPY15_10475	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY15_10485	COG0488	(ABC) transporter
HPY15_10495	COG0287	Prephenate dehydrogenase
HPY15_10495	COG1605	Chorismate mutase
HPY15_10500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY15_10505	COG3275	phosphorelay sensor kinase activity
HPY15_10510	COG3279	Response regulator of the LytR AlgR family
HPY15_10520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY15_10525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY15_10540	COG1966	Carbon starvation protein
HPY15_10545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY15_10550	COG1047	Peptidyl-prolyl cis-trans
HPY15_10555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY15_10565	COG0196	riboflavin kinase activity
HPY15_10570	COG0728	peptidoglycan biosynthetic process
HPY15_10575	COG0268	Binds directly to 16S ribosomal RNA
HPY15_10580	COG0640	Transcriptional regulator
HPY15_10585	COG0583	DNA-binding transcription factor activity
HPY15_10590	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY15_10600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY15_10605	COG0730	response to heat
HPY15_10610	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY15_10615	COG0494	nUDIX hydrolase
HPY15_10620	COG3066	DNA modification
HPY15_10625	COG0667	Aldo Keto reductase
HPY15_10635	COG2204	response regulator
HPY15_10640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY15_10660	COG0513	Belongs to the DEAD box helicase family
HPY15_10685	COG3153	acetyltransferase
HPY15_10690	COG3154	lipid carrier protein
HPY15_10700	COG0826	peptidase U32
HPY15_10705	COG0826	peptidase U32
HPY15_10730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY15_10740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY15_10745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY15_10750	COG0195	Participates in both transcription termination and antitermination
HPY15_10755	COG0779	Required for maturation of 30S ribosomal subunits
HPY15_10770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY15_10780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY15_10785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY15_10790	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY15_10795	COG1534	Rna-binding protein
HPY15_10800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY15_10810	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY15_10815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY15_10820	COG0739	heme binding
HPY15_10835	COG0316	Belongs to the HesB IscA family
HPY15_10840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY15_10845	COG0628	permease
HPY15_10850	COG2813	Specifically methylates the guanine in position
HPY15_10860	COG0747	negative chemotaxis
HPY15_10865	COG0601	transmembrane transport
HPY15_10870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY15_10875	COG0444	Belongs to the ABC transporter superfamily
HPY15_10880	COG4608	Belongs to the ABC transporter superfamily
HPY15_10890	COG2971	BadF BadG BcrA BcrD
HPY15_10910	COG3842	ATPase activity
HPY15_10920	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY15_10925	COG0004	ammonium transporteR
HPY15_10930	COG0347	Belongs to the P(II) protein family
HPY15_10935	COG3112	Uncharacterised protein family (UPF0231)
HPY15_10940	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY15_10945	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY15_10950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY15_10955	COG1643	Atp-dependent helicase
HPY15_10965	COG1489	DNA binding
HPY15_10975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY15_10985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY15_10990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY15_10995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY15_11000	COG0842	Transport permease protein
HPY15_11005	COG1131	(ABC) transporter
HPY15_11010	COG0659	secondary active sulfate transmembrane transporter activity
HPY15_11015	COG0288	reversible hydration of carbon dioxide
HPY15_11030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY15_11035	COG3107	peptidoglycan biosynthetic process
HPY15_11040	COG0792	nuclease activity
HPY15_11045	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY15_11050	COG2823	Periplasmic or secreted lipoprotein
HPY15_11055	COG2969	positive regulation of protein catabolic process
HPY15_11060	COG0625	glutathione transferase activity
HPY15_11065	COG2857	Cytochrome c1
HPY15_11070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY15_11075	COG0723	plastoquinol--plastocyanin reductase activity
HPY15_11080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY15_11085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY15_11090	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY15_11100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY15_11105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY15_11110	COG0335	large ribosomal subunit rRNA binding
HPY15_11115	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY15_11120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY15_11125	COG0228	four-way junction DNA binding
HPY15_11130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY15_11135	COG4137	Cytochrome C assembly protein
HPY15_11140	COG4536	flavin adenine dinucleotide binding
HPY15_11145	COG1854	S-ribosylhomocysteine lyase activity
HPY15_11150	COG2918	glutathione biosynthetic process
HPY15_11155	COG0612	Peptidase, M16
HPY15_11160	COG1238	metal cluster binding
HPY15_11170	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY15_11175	COG0511	ligase activity, forming carbon-carbon bonds
HPY15_11175	COG5016	pyruvate
HPY15_11180	COG3630	sodium ion export across plasma membrane
HPY15_11225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY15_11230	COG0527	aspartate kinase activity
HPY15_11235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY15_11240	COG2137	regulation of response to DNA damage stimulus
HPY15_11245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY15_11255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY15_11260	COG4208	sulfate ABC transporter
HPY15_11280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY15_11285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY15_11295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY15_11300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY15_11305	COG0585	pseudouridine synthase activity
HPY15_11310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY15_11315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY15_11320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY15_11325	COG1968	undecaprenyl-diphosphatase activity
HPY15_11330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY15_11335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY15_11340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY15_11350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY15_11355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY15_11360	COG1610	YqeY-like protein
HPY15_11365	COG0358	DNA primase activity
HPY15_11385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY15_11390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY15_11395	COG1349	DNA-binding transcription factor activity
HPY15_11420	COG1279	arginine transmembrane transporter activity
HPY15_11425	COG0668	transmembrane transport
HPY15_11430	COG0191	fructose-bisphosphate aldolase activity
HPY15_11435	COG0126	phosphoglycerate kinase activity
HPY15_11440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY15_11445	COG4771	TonB-dependent receptor
HPY15_11450	COG0583	DNA-binding transcription factor activity
HPY15_11455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY15_11460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY15_11465	COG3091	SprT-like family
HPY15_11470	COG2356	endonuclease I
HPY15_11475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY15_11480	COG0189	ligase activity
HPY15_11485	COG1678	Uncharacterized ACR, COG1678
HPY15_11490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY15_11495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY15_11515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY15_11520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY15_11525	COG0762	integral membrane protein
HPY15_11530	COG1872	DUF167
HPY15_11540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY15_11545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY15_11550	COG2066	Belongs to the glutaminase family
HPY15_11555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY15_11560	COG1194	a g-specific adenine glycosylase
HPY15_11565	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY15_11570	COG0741	lytic transglycosylase activity
HPY15_11595	COG0840	transmembrane signaling receptor activity
HPY15_11625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY15_11630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY15_11635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY15_11640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY15_11645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY15_11650	COG2967	ApaG domain
HPY15_11655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY15_11665	COG3610	response to peptide
HPY15_11670	COG2966	Psort location CytoplasmicMembrane, score
HPY15_11675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY15_11680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY15_11685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY15_11690	COG0142	geranyltranstransferase activity
HPY15_11695	COG0531	amino acid
HPY15_11700	COG0039	L-malate dehydrogenase activity
HPY15_11705	COG1438	arginine binding
HPY15_11710	COG2358	TRAP transporter, solute receptor (TAXI family
HPY15_11720	COG0589	response to stress
HPY15_11740	COG2235	arginine
HPY15_11745	COG0312	modulator of DNA gyrase
HPY15_11750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY15_11755	COG3164	Protein of unknown function
HPY15_11760	COG1530	ribonuclease E activity
HPY15_11765	COG0424	maF-like protein
HPY15_11770	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY15_11775	COG1792	Involved in formation and maintenance of cell shape
HPY15_11780	COG1077	Cell shape determining protein MreB Mrl
HPY15_11825	COG1459	type II secretion system
HPY15_11830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY15_11840	COG3409	Peptidoglycan-binding domain 1 protein
HPY15_11840	COG3267	Type II secretory pathway component ExeA
HPY15_11865	COG2199	diguanylate cyclase activity
HPY15_11865	COG2200	EAL domain
HPY15_11870	COG0629	single-stranded DNA binding
HPY15_11885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY15_11895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY15_11900	COG0527	aspartate kinase activity
HPY15_11905	COG1410	methionine synthase
HPY15_11905	COG0646	methionine synthase
HPY15_11945	COG0175	sulfate reduction
HPY15_11955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY15_11980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY15_11985	COG0735	belongs to the Fur family
HPY15_12000	COG0166	Belongs to the GPI family
HPY15_12005	COG0432	Pfam Uncharacterised protein family UPF0047
HPY15_12010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY15_12025	COG0359	binds to the 23S rRNA
HPY15_12030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY15_12035	COG2965	DNA replication, synthesis of RNA primer
HPY15_12040	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY15_12050	COG2906	2 iron, 2 sulfur cluster binding
HPY15_12055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY15_12060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY15_12065	COG0049	tRNA binding
HPY15_12080	COG2923	Belongs to the DsrF TusC family
HPY15_12085	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY15_12090	COG2964	Protein conserved in bacteria
HPY15_12095	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY15_12105	COG2900	Belongs to the SlyX family
HPY15_12110	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY15_12115	COG0330	HflC and HflK could
HPY15_12120	COG0330	HflC and HflK could
HPY15_12125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY15_12130	COG1923	regulation of RNA biosynthetic process
HPY15_12135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY15_12140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY15_12150	COG0802	atpase or kinase
HPY15_12155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY15_12200	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY15_12205	COG1162	GTPase activity
HPY15_12210	COG0688	phosphatidylethanolamine metabolic process
HPY15_12215	COG0471	metal ion transport
HPY15_12225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY15_12240	COG4942	peptidase
HPY15_12255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY15_12260	COG2816	NAD+ diphosphatase activity
HPY15_12265	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY15_12270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY15_12275	COG0085	RNA polymerase activity
HPY15_12280	COG0222	ribosome binding
HPY15_12285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY15_12295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY15_12300	COG0250	Participates in transcription elongation, termination and antitermination
HPY15_12305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY15_12310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY15_12335	COG1072	(Pantothenic acid kinase))
HPY15_12345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY15_12355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY15_12430	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY15_12445	COG3118	belongs to the thioredoxin family
HPY15_12450	COG0513	Belongs to the DEAD box helicase family
HPY15_12455	COG0248	Ppx GppA phosphatase
HPY15_12460	COG0784	Response regulator, receiver
HPY15_12460	COG2205	protein histidine kinase activity
HPY15_12465	COG2814	Major facilitator Superfamily
HPY15_12480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY15_12485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY15_12490	COG0511	ligase activity, forming carbon-carbon bonds
HPY15_12495	COG0439	Biotin carboxylase
HPY15_12500	COG2264	protein methyltransferase activity
HPY15_12505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY15_12510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY15_12515	COG1609	Transcriptional regulator
HPY15_12520	COG0129	dihydroxy-acid dehydratase activity
HPY15_12525	COG3265	gluconokinase activity
HPY15_12530	COG2610	gluconate transmembrane transporter activity
HPY15_12535	COG0800	Aldolase
HPY15_12555	COG0840	transmembrane signaling receptor activity
HPY15_12560	COG1982	Orn Lys Arg decarboxylase major
HPY15_12565	COG0531	amino acid
HPY15_12570	COG3710	Transcriptional regulator
HPY15_12575	COG0789	Transcriptional regulator
HPY15_12590	COG0151	Belongs to the GarS family
HPY15_12600	COG0776	regulation of translation
HPY15_12605	COG1253	flavin adenine dinucleotide binding
HPY15_12640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY15_12645	COG3068	Protein conserved in bacteria
HPY15_12655	COG1573	uracil-dna glycosylase
HPY15_12660	COG0668	transmembrane transport
HPY15_12675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY15_12725	COG1028	Short-chain dehydrogenase reductase Sdr
HPY15_12730	COG1083	cytidylyl-transferase
HPY15_12735	COG0673	inositol 2-dehydrogenase activity
HPY15_12750	COG2089	acid synthase
HPY15_12755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY15_12760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY15_12770	COG5433	transposase activity
HPY15_12780	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPY15_12785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY15_12795	COG0110	maltose O-acetyltransferase activity
HPY15_12810	COG0859	PFAM glycosyl transferase family 9
HPY15_12820	COG1519	Transferase
HPY15_12850	COG2755	lipolytic protein G-D-S-L family
HPY15_12850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPY15_12855	COG3642	lipopolysaccharide core region biosynthetic process
HPY15_12860	COG0859	PFAM glycosyl transferase family 9
HPY15_12865	COG0463	Glycosyl transferase, family 2
HPY15_12870	COG0859	PFAM glycosyl transferase family 9
HPY15_12875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY15_12880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY15_12890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY15_12895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY15_12900	COG2003	Belongs to the UPF0758 family
HPY15_12910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY15_12920	COG1309	transcriptional regulator
HPY15_12925	COG1560	Kdo2-lipid A biosynthetic process
HPY15_12930	COG1560	Kdo2-lipid A biosynthetic process
HPY15_12935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY15_12940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY15_12945	COG1561	YicC-like family, N-terminal region
HPY15_13015	COG2862	Uncharacterized protein family, UPF0114
HPY15_13020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY15_13020	COG1263	PTS System
HPY15_13025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY15_13045	COG1120	ATPase activity
HPY15_13050	COG4774	siderophore transport
HPY15_13055	COG1132	(ABC) transporter
HPY15_13070	COG0514	ATP-dependent DNA helicase (RecQ)
HPY15_13075	COG2962	Rard protein
HPY15_13080	COG0405	Gamma-glutamyltransferase
HPY15_13090	COG1280	lysine exporter protein (LysE YggA)
HPY15_13095	COG0210	DNA helicase
HPY15_13105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY15_13110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY15_13120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY15_13130	COG0747	negative chemotaxis
HPY15_13180	COG1309	transcriptional regulator
HPY15_13185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY15_13190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY15_13195	COG2960	long-chain fatty acid transporting porin activity
HPY15_13200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY15_13205	COG0583	DNA-binding transcription factor activity
HPY15_13275	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY15_13280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY15_13285	COG1739	Uncharacterized protein family UPF0029
HPY15_13290	COG1024	Enoyl-CoA hydratase
HPY15_13290	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY15_13295	COG0183	Belongs to the thiolase family
HPY15_13300	COG0583	DNA-binding transcription factor activity
HPY15_13305	COG2814	Major facilitator Superfamily
HPY15_13315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY15_13320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY15_13325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY15_13330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY15_13335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY15_13340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY15_13350	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY15_13355	COG3312	ion transport
HPY15_13360	COG1475	DNA binding
HPY15_13365	COG1192	Involved in chromosome partitioning
HPY15_13370	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY15_13375	COG0445	tRNA wobble uridine modification
HPY15_13380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY15_13385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY15_13390	COG0706	membrane insertase activity
HPY15_13400	COG0594	ribonuclease P activity
HPY15_13405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY15_13410	COG1126	abc transporter atp-binding protein
HPY15_13455	COG0217	transcriptional regulatory protein
HPY15_13460	COG2084	Dehydrogenase
HPY15_13475	COG2909	trisaccharide binding
HPY15_13480	COG0058	SHG alpha-glucan phosphorylase activity
HPY15_13485	COG1640	4-alpha-glucanotransferase
HPY15_13490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY15_13500	COG3501	Rhs element vgr protein
HPY15_13535	COG0471	metal ion transport
HPY15_13540	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY15_13580	COG0671	phosphoesterase, PA-phosphatase related
HPY15_13590	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY15_13600	COG1999	signal sequence binding
HPY15_13615	COG0786	glutamate:sodium symporter activity
HPY15_13635	COG3706	GGDEF domain
HPY15_13650	COG0813	purine-nucleoside phosphorylase activity
HPY15_13655	COG3272	Protein of unknown function (DUF1722)
HPY15_13665	COG0415	Belongs to the DNA photolyase family
HPY15_13670	COG1388	LysM domain
HPY15_13670	COG1376	ErfK ybiS ycfS ynhG family protein
HPY15_13680	COG0513	Belongs to the DEAD box helicase family
HPY15_13685	COG1770	oligopeptidase
HPY15_13715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY15_13720	COG0573	inorganic phosphate transmembrane transporter activity
HPY15_13725	COG0581	inorganic phosphate transmembrane transporter activity
HPY15_13730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY15_13755	COG0659	secondary active sulfate transmembrane transporter activity
HPY15_13765	COG0739	heme binding
HPY15_13770	COG5001	Diguanylate cyclase
HPY15_13770	COG3300	MHYT domain
HPY15_13775	COG0583	DNA-binding transcription factor activity
HPY15_13780	COG2814	Major facilitator Superfamily
HPY15_13800	COG1301	dicarboxylic acid transport
HPY15_13810	COG1342	Belongs to the UPF0251 family
HPY15_13840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY15_13845	COG0673	inositol 2-dehydrogenase activity
HPY15_13855	COG2771	luxR family
HPY15_13855	COG2200	EAL domain
HPY15_13860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY15_13870	COG0564	pseudouridine synthase activity
HPY15_13975	COG1869	D-ribose catabolic process
HPY15_13980	COG1129	ABC transporter
HPY15_13985	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY15_13990	COG1879	ABC-type sugar transport system periplasmic component
HPY15_13995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY15_14000	COG1609	Transcriptional regulator
HPY15_14010	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY15_14020	COG0584	glycerophosphoryl diester phosphodiesterase
HPY15_14025	COG2271	Major facilitator Superfamily
HPY15_14060	COG0579	oxidoreductase
HPY15_14070	COG0242	peptide deformylase activity
HPY15_14075	COG1017	nitric oxide dioxygenase activity
HPY15_14075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY15_14080	COG1320	monovalent cation:proton antiporter activity
HPY15_14085	COG2212	antiporter activity
HPY15_14105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY15_14105	COG2111	Na H antiporter
HPY15_14115	COG0589	response to stress
HPY15_14120	COG0814	amino acid
HPY15_14135	COG3530	Putative quorum-sensing-regulated virulence factor
HPY15_14145	COG5001	Diguanylate cyclase
HPY15_14145	COG5002	protein histidine kinase activity
HPY15_14150	COG1278	Cold shock
HPY15_14165	COG2304	oxidoreductase activity
HPY15_14185	COG0714	Associated with various cellular activities
HPY15_14190	COG0840	transmembrane signaling receptor activity
HPY15_14205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY15_14210	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY15_14220	COG3604	Transcriptional regulator
HPY15_14225	COG1017	nitric oxide dioxygenase activity
HPY15_14225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY15_14230	COG1278	Cold shock
HPY15_14235	COG3036	rescue of stalled ribosome
HPY15_14260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY15_14260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY15_14265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY15_14275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY15_14285	COG0516	GMP reductase activity
HPY15_14295	COG0513	Belongs to the DEAD box helicase family
HPY15_14300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY15_14305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY15_14310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY15_14315	COG3437	response regulator, receiver
HPY15_14315	COG0784	Response regulator, receiver
HPY15_14320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY15_14320	COG4191	Histidine kinase
HPY15_14330	COG1757	Na H antiporter
HPY15_14335	COG2814	Major facilitator Superfamily
HPY15_14345	COG3240	lipase activity
HPY15_14355	COG0840	transmembrane signaling receptor activity
HPY15_14360	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY15_14365	COG5380	lipid catabolic process
HPY15_14390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY15_14395	COG4605	iron ion homeostasis
HPY15_14400	COG4604	ABC transporter, ATP-binding protein
HPY15_14405	COG2207	Transcriptional regulator
HPY15_14420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY15_14440	COG0745	RESPONSE REGULATOR receiver
HPY15_14450	COG3623	hexulose-6-phosphate isomerase
HPY15_14455	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY15_14460	COG0561	phosphatase activity
HPY15_14505	COG0745	RESPONSE REGULATOR receiver
HPY15_14510	COG5002	protein histidine kinase activity
HPY15_14535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY15_14550	COG0583	DNA-binding transcription factor activity
HPY15_14565	COG1686	Belongs to the peptidase S11 family
HPY15_14585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY15_14585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY15_14590	COG0509	glycine decarboxylation via glycine cleavage system
HPY15_14595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY15_14620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY15_14625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY15_14645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY15_14725	COG0456	acetyltransferase
HPY15_14805	COG1715	Restriction endonuclease
HPY15_14960	COG1714	RDD family
HPY15_15080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY15_15080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY15_15095	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY15_15170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY15_15280	COG3041	Addiction module toxin RelE StbE family
HPY15_15295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY15_15320	COG3093	addiction module antidote protein HigA
HPY15_15325	COG3549	Plasmid maintenance system killer
HPY15_15365	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY15_15375	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY15_15380	COG2944	sequence-specific DNA binding
HPY15_15410	COG0456	acetyltransferase
HPY15_15445	COG0346	lactoylglutathione lyase activity
HPY15_15500	COG0494	nUDIX hydrolase
HPY15_15620	COG0346	lactoylglutathione lyase activity
HPY15_15640	COG2161	toxin-antitoxin pair type II binding
HPY15_15645	COG4115	mRNA cleavage
HPY15_15670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY15_15735	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY15_15790	COG1328	CTP reductase activity
HPY15_15795	COG0602	queuosine metabolic process
HPY15_15805	COG0189	ligase activity
HPY15_15805	COG4067	protein conserved in archaea
HPY15_15810	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY15_15810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY15_15810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY15_15815	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY15_15820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY15_15820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY15_15825	COG1609	Transcriptional regulator
HPY15_15830	COG0420	3'-5' exonuclease activity
HPY15_15835	COG0419	ATPase involved in DNA repair
HPY15_15840	COG2205	protein histidine kinase activity
HPY15_15840	COG0784	Response regulator, receiver
HPY15_15845	COG0156	8-amino-7-oxononanoate synthase activity
HPY15_15855	COG0038	chloride channel
HPY15_15860	COG0523	cobalamin synthesis protein
HPY15_15870	COG3158	transport of potassium into the cell
HPY15_15875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY15_15875	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY15_15875	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY15_15875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY15_15880	COG2205	protein histidine kinase activity
HPY15_15885	COG0745	RESPONSE REGULATOR receiver
HPY15_15890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY15_15895	COG0586	Pfam SNARE associated Golgi protein
HPY15_15905	COG2200	EAL domain
HPY15_15915	COG3038	cytochrome b561
HPY15_15925	COG2116	formate transmembrane transporter activity
HPY15_15930	COG0583	DNA-binding transcription factor activity
HPY15_15940	COG3593	DNA synthesis involved in DNA repair
HPY15_15945	COG0737	Belongs to the 5'-nucleotidase family
HPY15_15960	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY15_16010	COG3706	GGDEF domain
HPY15_16025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY15_16030	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY15_16055	COG3140	Belongs to the UPF0181 family
HPY15_16070	COG0023	Translation Initiation Factor
HPY15_16090	COG1042	CoA-binding domain protein
HPY15_16090	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY15_16090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY15_16095	COG0583	DNA-binding transcription factor activity
HPY15_16100	COG4771	TonB-dependent receptor
HPY15_16115	COG2050	protein possibly involved in aromatic compounds catabolism
HPY15_16135	COG0625	glutathione transferase activity
HPY15_16150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY15_16155	COG4172	Belongs to the ABC transporter superfamily
HPY15_16160	COG4239	(ABC) transporter, permease
HPY15_16165	COG4174	ABC transporter (Permease)
HPY15_16170	COG4166	transmembrane transport
HPY15_16195	COG3104	oligopeptide transport
HPY15_16215	COG3842	ATPase activity
HPY15_16220	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY15_16225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY15_16235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY15_16240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY15_16245	COG1011	Hydrolase
HPY15_16255	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY15_16260	COG1970	mechanosensitive ion channel activity
HPY15_16265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY15_16270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY15_16270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY15_16275	COG0302	gtp cyclohydrolase
HPY15_16285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY15_16295	COG2897	thiosulfate sulfurtransferase activity
HPY15_16300	COG2390	Transcriptional regulator
HPY15_16310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY15_16335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY15_16360	COG0583	DNA-binding transcription factor activity
HPY15_16365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY15_16405	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY15_16450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY15_16450	COG1263	PTS System
HPY15_16460	COG1621	beta-fructofuranosidase activity
HPY15_16465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY15_16470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY15_16475	COG0840	transmembrane signaling receptor activity
HPY15_16480	COG2885	chlorophyll binding
HPY15_16485	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY15_16490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY15_16495	COG0840	transmembrane signaling receptor activity
HPY15_16500	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY15_16505	COG1760	l-serine dehydratase
HPY15_16510	COG2197	response regulator
HPY15_16515	COG3850	Histidine kinase
HPY15_16520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY15_16520	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY15_16530	COG0243	molybdopterin cofactor binding
HPY15_16550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY15_16555	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY15_16565	COG0183	Belongs to the thiolase family
HPY15_16575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY15_16580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY15_16595	COG3706	GGDEF domain
HPY15_16600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY15_16610	COG1979	alcohol dehydrogenase
HPY15_16625	COG4191	Histidine kinase
HPY15_16635	COG2271	Major facilitator Superfamily
HPY15_16640	COG0469	pyruvate kinase activity
HPY15_16645	COG2198	Histidine kinase
HPY15_16645	COG2205	protein histidine kinase activity
HPY15_16645	COG0784	Response regulator, receiver
HPY15_16650	COG1879	ABC-type sugar transport system periplasmic component
HPY15_16655	COG1803	Methylglyoxal synthase
HPY15_16660	COG1335	isochorismatase
HPY15_16665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY15_16680	COG0210	DNA helicase
HPY15_16685	COG1289	transmembrane transporter activity
HPY15_16715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY15_16720	COG4149	molybdate abc transporter
HPY15_16725	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY15_16730	COG1492	cobalamin metabolic process
HPY15_16775	COG0784	Response regulator, receiver
HPY15_16775	COG5002	protein histidine kinase activity
HPY15_16780	COG1879	ABC-type sugar transport system periplasmic component
HPY15_16790	COG2827	Endonuclease containing a URI domain
HPY15_16805	COG2926	Belongs to the UPF0265 family
HPY15_16815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY15_16820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY15_16825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY15_16830	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPY15_16835	COG0247	lactate metabolic process
HPY15_16840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY15_16845	COG3118	belongs to the thioredoxin family
HPY15_16875	COG0583	DNA-binding transcription factor activity
HPY15_16880	COG4160	amino acid transport
HPY15_16885	COG4215	(ABC) transporter
HPY15_16890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY15_16895	COG1126	abc transporter atp-binding protein
HPY15_16905	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY15_16915	COG0494	nUDIX hydrolase
HPY15_16930	COG1309	transcriptional regulator
HPY15_16935	COG0513	Belongs to the DEAD box helicase family
HPY15_16940	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY15_16945	COG0814	amino acid
HPY15_16955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY15_16960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY15_16970	COG1984	allophanate hydrolase subunit 2
HPY15_16985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY15_16990	COG4181	ATPase activity
HPY15_17000	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY15_17005	COG1716	ATPase activity
HPY15_17005	COG5001	Diguanylate cyclase
HPY15_17015	COG0484	heat shock protein binding
HPY15_17030	COG0546	phosphoglycolate phosphatase activity
HPY15_17045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY15_17050	COG1368	sulfuric ester hydrolase activity
HPY15_17060	COG0513	Belongs to the DEAD box helicase family
HPY15_17075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY15_17085	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY15_17090	COG3397	chitin binding
HPY15_17095	COG3227	Zinc metalloprotease (Elastase)
HPY15_17110	COG1166	arginine decarboxylase activity
HPY15_17120	COG2239	Acts as a magnesium transporter
HPY15_17125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY15_17130	COG0459	protein refolding
HPY15_17140	COG0527	aspartate kinase activity
HPY15_17145	COG0662	Cupin 2, conserved barrel domain protein
HPY15_17150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY15_17155	COG0456	acetyltransferase
HPY15_17160	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY15_17165	COG3186	Phenylalanine-4-hydroxylase
HPY15_17170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY15_17185	COG2264	protein methyltransferase activity
HPY15_17210	COG1253	flavin adenine dinucleotide binding
HPY15_17215	COG1765	OsmC-like protein
HPY15_17245	COG1252	NADH dehydrogenase
HPY15_17250	COG0531	amino acid
HPY15_17255	COG3706	GGDEF domain
HPY15_17265	COG3279	Response regulator of the LytR AlgR family
HPY15_17270	COG3275	phosphorelay sensor kinase activity
HPY15_17285	COG1136	(ABC) transporter
HPY15_17285	COG0577	efflux transmembrane transporter activity
HPY15_17290	COG1136	(ABC) transporter
HPY15_17300	COG4989	oxidoreductase activity
HPY15_17305	COG0366	Alpha amylase catalytic
HPY15_17315	COG2067	long-chain fatty acid transport protein
HPY15_17320	COG2267	carboxylic ester hydrolase activity
HPY15_17330	COG3227	Zinc metalloprotease (Elastase)
HPY15_17340	COG3047	cAMP biosynthetic process
HPY15_17350	COG1686	Belongs to the peptidase S11 family
HPY15_17355	COG0557	exoribonuclease II activity
HPY15_17360	COG1278	Cold shock
HPY15_17370	COG3048	D-serine ammonia-lyase activity
HPY15_17420	COG1063	alcohol dehydrogenase
HPY15_17430	COG2873	o-acetylhomoserine
HPY15_17440	COG0346	lactoylglutathione lyase activity
HPY15_17460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY15_17465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY15_17470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY15_17475	COG0363	glucosamine-6-phosphate deaminase activity
HPY15_17480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY15_17505	COG1929	Belongs to the glycerate kinase type-1 family
HPY15_17515	COG0748	coenzyme F420 binding
HPY15_17520	COG3721	Heme iron utilization protein
HPY15_17530	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY15_17535	COG0811	peptide transport
HPY15_17540	COG0848	biopolymer transport protein
HPY15_17545	COG4558	Periplasmic binding protein
HPY15_17550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY15_17555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY15_17590	COG3217	Mosc domain protein beta barrel domain protein
HPY15_17590	COG0633	Ferredoxin
HPY15_17590	COG3217	Mosc domain protein beta barrel domain protein
HPY15_17590	COG0633	Ferredoxin
HPY15_17595	COG0418	dihydroorotase activity
HPY15_17600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY15_17605	COG2354	Protein conserved in bacteria
HPY15_17615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY15_17620	COG1278	Cold shock
HPY15_17645	COG3706	GGDEF domain
HPY15_17650	COG1349	DNA-binding transcription factor activity
HPY15_17665	COG3833	ABC-type maltose transport systems, permease component
HPY15_17670	COG1175	transmembrane transport
HPY15_17680	COG3842	ATPase activity
HPY15_17685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY15_17700	COG0393	Putative heavy-metal-binding
HPY15_17710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY15_17715	COG0835	chemotaxis
HPY15_17715	COG0784	Response regulator, receiver
HPY15_17720	COG1846	Transcriptional regulator
HPY15_17725	COG3706	GGDEF domain
HPY15_17760	COG0583	DNA-binding transcription factor activity
HPY15_17765	COG5001	Diguanylate cyclase
HPY15_17775	COG1741	Belongs to the pirin family
HPY15_17780	COG3123	guanosine phosphorylase activity
HPY15_17790	COG2211	Major facilitator Superfamily
HPY15_17800	COG1067	ATP-dependent peptidase activity
HPY15_17810	COG4172	Belongs to the ABC transporter superfamily
HPY15_17830	COG0583	DNA-binding transcription factor activity
HPY15_17840	COG1620	l-lactate permease
HPY15_17855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY15_17865	COG0840	transmembrane signaling receptor activity
HPY15_17885	COG0513	Belongs to the DEAD box helicase family
HPY15_17890	COG0583	DNA-binding transcription factor activity
HPY15_17900	COG1902	pentaerythritol trinitrate reductase activity
HPY15_17910	COG1132	(ABC) transporter
HPY15_17920	COG1902	pentaerythritol trinitrate reductase activity
HPY15_17930	COG1280	lysine exporter protein (LysE YggA)
HPY15_17935	COG2207	Transcriptional regulator
HPY15_17955	COG1846	Transcriptional regulator
HPY15_17960	COG1764	response to oxidative stress
HPY15_17965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY15_17970	COG0697	spore germination
HPY15_17980	COG0700	Nucleoside recognition
HPY15_17985	COG3366	ferrous iron transmembrane transporter activity
HPY15_17990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY15_18000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY15_18005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY15_18010	COG2259	Doxx family
HPY15_18035	COG0363	glucosamine-6-phosphate deaminase activity
HPY15_18050	COG4580	involved in the transport of maltose and maltodextrins
HPY15_18065	COG0840	transmembrane signaling receptor activity
HPY15_18080	COG0840	transmembrane signaling receptor activity
HPY15_18090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY15_18095	COG1126	abc transporter atp-binding protein
HPY15_18105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY15_18110	COG4597	amino acid ABC transporter
HPY15_18125	COG0246	Mannitol dehydrogenase
HPY15_18130	COG3722	fumarate hydratase activity
HPY15_18135	COG0673	inositol 2-dehydrogenase activity
HPY15_18160	COG0697	spore germination
HPY15_18175	COG2910	NAD(P)H-binding
HPY15_18185	COG0840	transmembrane signaling receptor activity
HPY15_18190	COG4221	oxidoreductase activity
HPY15_18200	COG1901	pseudouridine methyltransferase
HPY15_18215	COG0531	amino acid
HPY15_18250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY15_18275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY15_18315	COG0745	RESPONSE REGULATOR receiver
HPY15_18340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY15_18345	COG0840	transmembrane signaling receptor activity
HPY15_18350	COG0835	chemotaxis
HPY15_18355	COG0835	chemotaxis
HPY15_18360	COG0643	Histidine kinase
HPY15_18360	COG2198	Histidine kinase
HPY15_18380	COG0601	transmembrane transport
HPY15_18385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY15_18390	COG4608	Belongs to the ABC transporter superfamily
HPY15_18395	COG2194	sulfuric ester hydrolase activity
HPY15_18400	COG0642	Histidine kinase
HPY15_18405	COG0745	RESPONSE REGULATOR receiver
HPY15_18415	COG4221	oxidoreductase activity
HPY15_18435	COG1444	tRNA N-acetyltransferase activity
HPY15_18440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine