locus-tag	class	description
HPY07_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY07_00010	COG0592	DNA-directed DNA polymerase activity
HPY07_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY07_00020	COG0187	DNA topoisomerase II activity
HPY07_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY07_00035	COG3977	Valine--pyruvate aminotransferase
HPY07_00040	COG0751	glycine-tRNA ligase activity
HPY07_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY07_00050	COG2119	membrane
HPY07_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY07_00070	COG0604	alcohol dehydrogenase
HPY07_00080	COG0129	dihydroxy-acid dehydratase activity
HPY07_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY07_00100	COG0606	chelatase, subunit chli
HPY07_00105	COG0204	Acyl-transferase
HPY07_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY07_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY07_00125	COG3084	Protein conserved in bacteria
HPY07_00130	COG4326	sporulation control protein
HPY07_00135	COG1272	protein, Hemolysin III
HPY07_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY07_00150	COG0569	domain protein
HPY07_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY07_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY07_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY07_00165	COG0242	peptide deformylase activity
HPY07_00170	COG1652	LysM domain
HPY07_00175	COG0758	DNA mediated transformation
HPY07_00180	COG2922	Belongs to the Smg family
HPY07_00185	COG0551	DNA topoisomerase type I activity
HPY07_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY07_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY07_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY07_00205	COG0408	coproporphyrinogen oxidase activity
HPY07_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY07_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY07_00255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY07_00260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY07_00270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY07_00275	COG2104	thiamine diphosphate biosynthetic process
HPY07_00280	COG2022	thiamine diphosphate biosynthetic process
HPY07_00285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY07_00290	COG0006	proline dipeptidase activity
HPY07_00290	COG0006	proline dipeptidase activity
HPY07_00310	COG1522	sequence-specific DNA binding
HPY07_00315	COG5001	Diguanylate cyclase
HPY07_00315	COG5002	protein histidine kinase activity
HPY07_00335	COG0589	response to stress
HPY07_00340	COG1528	Iron-storage protein
HPY07_00350	COG2081	HI0933 family
HPY07_00360	COG1322	Protein conserved in bacteria
HPY07_00365	COG2226	methyltransferase
HPY07_00380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY07_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY07_00390	COG0805	protein transport
HPY07_00395	COG1858	cytochrome C peroxidase
HPY07_00400	COG0534	Mate efflux family protein
HPY07_00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY07_00415	COG2937	Belongs to the GPAT DAPAT family
HPY07_00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY07_00425	COG3161	chorismate lyase activity
HPY07_00430	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY07_00445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY07_00450	COG0084	hydrolase, TatD family'
HPY07_00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY07_00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY07_00485	COG3078	GTPase activator activity
HPY07_00500	COG3071	HemY protein
HPY07_00505	COG2959	enzyme of heme biosynthesis
HPY07_00510	COG1587	Uroporphyrinogen-III synthase
HPY07_00515	COG0181	hydroxymethylbilane synthase activity
HPY07_00525	COG1965	Belongs to the frataxin family
HPY07_00535	COG0019	diaminopimelate decarboxylase activity
HPY07_00540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY07_00550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY07_00555	COG1011	Hydrolase
HPY07_00560	COG2200	EAL domain
HPY07_00560	COG2199	diguanylate cyclase activity
HPY07_00560	COG3287	FIST C domain
HPY07_00575	COG0561	phosphatase activity
HPY07_00580	COG2267	carboxylic ester hydrolase activity
HPY07_00585	COG1280	lysine exporter protein (LysE YggA)
HPY07_00590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY07_00595	COG0783	Belongs to the Dps family
HPY07_00625	COG0742	ribosomal rna small subunit methyltransferase
HPY07_00630	COG0552	protein localization to endoplasmic reticulum
HPY07_00635	COG2884	Cell division ATP-binding protein ftsE
HPY07_00640	COG2177	Part of the ABC transporter FtsEX involved in
HPY07_00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY07_00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY07_00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY07_00675	COG1404	Belongs to the peptidase S8 family
HPY07_00680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY07_00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY07_00755	COG5001	Diguanylate cyclase
HPY07_00755	COG3300	MHYT domain
HPY07_00765	COG3852	Histidine kinase
HPY07_00775	COG0174	glutamine synthetase
HPY07_00795	COG1295	ribonuclease BN
HPY07_00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY07_00805	COG0456	acetyltransferase
HPY07_00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY07_00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY07_00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY07_00830	COG3031	protein transport across the cell outer membrane
HPY07_00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY07_00845	COG1459	type II secretion system
HPY07_00850	COG2165	general secretion pathway protein
HPY07_00855	COG2165	general secretion pathway protein
HPY07_00860	COG2165	general secretion pathway protein
HPY07_00865	COG4795	General secretion pathway protein
HPY07_00870	COG3156	type II secretion system protein K
HPY07_00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY07_00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY07_00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY07_00895	COG0494	nUDIX hydrolase
HPY07_00905	COG1040	competence protein
HPY07_00915	COG0596	Alpha beta hydrolase
HPY07_00925	COG2183	response to ionizing radiation
HPY07_00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY07_00940	COG0745	RESPONSE REGULATOR receiver
HPY07_00950	COG2233	PERMEase
HPY07_00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY07_00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY07_00965	COG1758	RNA polymerase activity
HPY07_00970	COG0194	GDP metabolic process
HPY07_00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY07_00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY07_01000	COG4232	protein-disulfide reductase activity
HPY07_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY07_01015	COG1027	Aspartate ammonia-lyase
HPY07_01020	COG3706	GGDEF domain
HPY07_01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY07_01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY07_01040	COG2205	protein histidine kinase activity
HPY07_01045	COG0745	RESPONSE REGULATOR receiver
HPY07_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY07_01060	COG0205	6-phosphofructokinase activity
HPY07_01065	COG1494	fructose-1,6-bisphosphatase
HPY07_01070	COG3074	FtsZ-dependent cytokinesis
HPY07_01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY07_01080	COG0527	aspartate kinase activity
HPY07_01080	COG0460	homoserine dehydrogenase
HPY07_01085	COG0626	cystathionine gamma-synthase activity
HPY07_01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY07_01095	COG0281	malic enzyme
HPY07_01100	COG0254	rRNA binding
HPY07_01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY07_01110	COG1609	Transcriptional regulator
HPY07_01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY07_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY07_01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY07_01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY07_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY07_01140	COG0534	Mate efflux family protein
HPY07_01145	COG0149	triose-phosphate isomerase activity
HPY07_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY07_01175	COG0459	protein refolding
HPY07_01185	COG1509	lysine 2,3-aminomutase activity
HPY07_01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY07_01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY07_01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY07_01210	COG1053	succinate dehydrogenase
HPY07_01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY07_01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY07_01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY07_01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY07_01235	COG1045	serine acetyltransferase
HPY07_01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY07_01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY07_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY07_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY07_01265	COG0137	argininosuccinate synthase activity
HPY07_01270	COG0165	Argininosuccinate lyase
HPY07_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY07_01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY07_01285	COG0678	peroxiredoxin activity
HPY07_01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY07_01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY07_01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY07_01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY07_01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY07_01350	COG0546	phosphoglycolate phosphatase activity
HPY07_01355	COG0180	Tryptophanyl-tRNA synthetase
HPY07_01375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY07_01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY07_01410	COG3954	Phosphoribulokinase
HPY07_01420	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY07_01430	COG0488	(ABC) transporter
HPY07_01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY07_01450	COG1047	Peptidyl-prolyl cis-trans
HPY07_01460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY07_01465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY07_01470	COG3083	sulfuric ester hydrolase activity
HPY07_01475	COG0557	exoribonuclease II activity
HPY07_01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY07_01485	COG0051	transcription antitermination factor activity, RNA binding
HPY07_01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY07_01495	COG0088	Forms part of the polypeptide exit tunnel
HPY07_01500	COG0089	rRNA binding
HPY07_01505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY07_01510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY07_01515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY07_01520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY07_01525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY07_01530	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY07_01535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY07_01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY07_01545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY07_01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY07_01555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY07_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY07_01565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY07_01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY07_01575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY07_01580	COG1841	ribosomal large subunit assembly
HPY07_01590	COG0201	protein transport
HPY07_01595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY07_01600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY07_01605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY07_01610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY07_01615	COG0202	RNA polymerase activity
HPY07_01620	COG0203	ribosomal protein L17
HPY07_01630	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY07_01635	COG3266	domain, Protein
HPY07_01635	COG3061	Opacity-associated protein A
HPY07_01640	COG0697	spore germination
HPY07_01645	COG2153	protein acetylation
HPY07_01650	COG0513	Belongs to the DEAD box helicase family
HPY07_01660	COG0737	Belongs to the 5'-nucleotidase family
HPY07_01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY07_01665	COG1648	precorrin-2 dehydrogenase activity
HPY07_01670	COG0175	sulfate reduction
HPY07_01675	COG2895	sulfate adenylyltransferase (ATP) activity
HPY07_01680	COG0529	Catalyzes the synthesis of activated sulfate
HPY07_01700	COG1136	(ABC) transporter
HPY07_01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY07_01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY07_01725	COG0729	surface antigen
HPY07_01735	COG2105	PFAM AIG2 family protein
HPY07_01740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY07_01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY07_01755	COG0163	prenyltransferase activity
HPY07_01765	COG1178	ABC-type Fe3 transport system permease component
HPY07_01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY07_01775	COG3028	Belongs to the UPF0307 family
HPY07_01780	COG0312	modulator of DNA gyrase
HPY07_01785	COG2239	Acts as a magnesium transporter
HPY07_01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY07_01795	COG1660	Displays ATPase and GTPase activities
HPY07_01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY07_01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY07_01815	COG1137	ATPase activity
HPY07_01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY07_01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY07_01835	COG0517	IMP dehydrogenase activity
HPY07_01845	COG1127	ABC transporter
HPY07_01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY07_01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY07_01860	COG2854	intermembrane phospholipid transfer
HPY07_01870	COG5007	Belongs to the BolA IbaG family
HPY07_01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY07_01890	COG0251	oxidation-reduction process
HPY07_01900	COG0540	Belongs to the ATCase OTCase family
HPY07_01910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY07_01915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY07_01920	COG0564	pseudouridine synthase activity
HPY07_01925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY07_01930	COG0525	valine-tRNA ligase activity
HPY07_01935	COG2927	DNA polymerase III (CHI subunit)
HPY07_01940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY07_01945	COG0795	lipopolysaccharide-transporting ATPase activity
HPY07_01950	COG0795	lipopolysaccharide-transporting ATPase activity
HPY07_01965	COG3437	response regulator, receiver
HPY07_02005	COG0066	3-isopropylmalate dehydratase activity
HPY07_02010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY07_02015	COG0473	3-isopropylmalate dehydrogenase activity
HPY07_02035	COG0583	DNA-binding transcription factor activity
HPY07_02040	COG1022	Amp-dependent synthetase and ligase
HPY07_02045	COG0028	Belongs to the TPP enzyme family
HPY07_02050	COG0440	acetolactate synthase activity
HPY07_02055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY07_02060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY07_02065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY07_02075	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY07_02080	COG3079	Belongs to the UPF0149 family
HPY07_02085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY07_02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY07_02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY07_02120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY07_02125	COG1595	DNA-templated transcription, initiation
HPY07_02140	COG3086	response to oxidative stress
HPY07_02145	COG0481	GTPase activity
HPY07_02155	COG0571	ribonuclease III activity
HPY07_02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY07_02165	COG1381	Involved in DNA repair and RecF pathway recombination
HPY07_02170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY07_02200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY07_02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY07_02210	COG3956	TIGRFAM MazG family protein
HPY07_02215	COG0504	CTP synthase activity
HPY07_02220	COG0148	phosphopyruvate hydratase activity
HPY07_02230	COG3267	Type II secretory pathway component ExeA
HPY07_02230	COG3409	Peptidoglycan-binding domain 1 protein
HPY07_02240	COG4991	sh3 domain protein
HPY07_02245	COG0306	phosphate transporter
HPY07_02250	COG1392	Phosphate transport regulator
HPY07_02255	COG3025	triphosphatase activity
HPY07_02260	COG0840	transmembrane signaling receptor activity
HPY07_02265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY07_02270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY07_02270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY07_02275	COG1538	Outer membrane efflux protein
HPY07_02280	COG0494	nUDIX hydrolase
HPY07_02285	COG3151	Protein conserved in bacteria
HPY07_02295	COG3150	esterase
HPY07_02300	COG0187	DNA topoisomerase II activity
HPY07_02305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY07_02315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY07_02320	COG0237	dephospho-CoA kinase activity
HPY07_02330	COG1459	type II secretion system
HPY07_02335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY07_02345	COG0157	Belongs to the NadC ModD family
HPY07_02360	COG0716	FMN binding
HPY07_02365	COG4974	Belongs to the 'phage' integrase family
HPY07_02370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY07_02375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY07_02380	COG2186	Transcriptional regulator
HPY07_02385	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY07_02390	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY07_02395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY07_02410	COG3116	cell division
HPY07_02415	COG0768	penicillin binding
HPY07_02420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY07_02425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY07_02435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY07_02440	COG0772	Belongs to the SEDS family
HPY07_02445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY07_02450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY07_02455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY07_02460	COG0849	cell division
HPY07_02465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY07_02470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY07_02480	COG0653	protein targeting
HPY07_02485	COG0494	nUDIX hydrolase
HPY07_02490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY07_02500	COG0505	Belongs to the CarA family
HPY07_02505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY07_02520	COG0730	response to heat
HPY07_02525	COG0583	DNA-binding transcription factor activity
HPY07_02530	COG2860	membrane
HPY07_02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY07_02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY07_02555	COG0493	'glutamate synthase
HPY07_02560	COG0067	glutamate synthase
HPY07_02560	COG0069	glutamate synthase activity
HPY07_02560	COG0070	glutamate synthase
HPY07_02570	COG0069	glutamate synthase activity
HPY07_02570	COG0070	glutamate synthase
HPY07_02570	COG0067	glutamate synthase
HPY07_02575	COG1242	4 iron, 4 sulfur cluster binding
HPY07_02580	COG2203	Gaf domain
HPY07_02580	COG5001	Diguanylate cyclase
HPY07_02580	COG3706	GGDEF domain
HPY07_02580	COG4251	negative regulation of phosphorylation
HPY07_02585	COG2198	Histidine kinase
HPY07_02585	COG5002	protein histidine kinase activity
HPY07_02585	COG0784	Response regulator, receiver
HPY07_02590	COG0745	RESPONSE REGULATOR receiver
HPY07_02600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY07_02620	COG0083	homoserine kinase activity
HPY07_02625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY07_02630	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY07_02635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY07_02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY07_02655	COG1115	amino acid carrier protein
HPY07_02660	COG3022	response to hydroperoxide
HPY07_02670	COG0084	hydrolase, TatD family'
HPY07_02675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY07_02685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY07_02690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY07_02695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY07_02700	COG0813	purine-nucleoside phosphorylase activity
HPY07_02710	COG0560	Phosphoserine phosphatase
HPY07_02720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY07_02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY07_02730	COG1022	Amp-dependent synthetase and ligase
HPY07_02745	COG3250	beta-galactosidase activity
HPY07_02750	COG1609	Transcriptional regulator
HPY07_02755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY07_02770	COG0569	domain protein
HPY07_02770	COG0189	ligase activity
HPY07_02775	COG0456	acetyltransferase
HPY07_02785	COG2171	N-acyltransferase activity
HPY07_02790	COG3141	response to X-ray
HPY07_02805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY07_02810	COG1074	ATP-dependent DNA helicase activity
HPY07_02815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY07_02825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY07_02825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY07_02835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY07_02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY07_02845	COG2166	iron-sulfur cluster assembly
HPY07_02850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY07_02855	COG0693	protein deglycase activity
HPY07_02860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY07_02865	COG3248	Nucleoside-binding outer membrane protein
HPY07_02875	COG1595	DNA-templated transcription, initiation
HPY07_02885	COG2211	Major facilitator Superfamily
HPY07_02890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY07_02900	COG2813	Specifically methylates the guanine in position
HPY07_02905	COG0271	Belongs to the BolA IbaG family
HPY07_02910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY07_02915	COG1805	sodium ion transport
HPY07_02920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY07_02925	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY07_02930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY07_02935	COG2871	sodium ion transport
HPY07_02940	COG1477	protein flavinylation
HPY07_02960	COG3706	GGDEF domain
HPY07_02965	COG0733	neurotransmitter:sodium symporter activity
HPY07_02975	COG0189	ligase activity
HPY07_02980	COG4067	protein conserved in archaea
HPY07_02980	COG0189	ligase activity
HPY07_02985	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY07_02990	COG2252	PERMEase
HPY07_02995	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY07_03010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY07_03015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY07_03020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY07_03025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY07_03025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY07_03040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY07_03045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY07_03050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY07_03055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY07_03065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY07_03070	COG0024	Methionine aminopeptidase
HPY07_03075	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY07_03080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY07_03085	COG0528	UMP kinase activity
HPY07_03090	COG0233	cytoplasmic translational termination
HPY07_03095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY07_03100	COG0575	Belongs to the CDS family
HPY07_03105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY07_03110	COG0750	zinc metalloprotease
HPY07_03120	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY07_03125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY07_03130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY07_03135	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY07_03140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY07_03145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY07_03150	COG0587	DNA-directed DNA polymerase activity
HPY07_03155	COG0825	malonyl-CoA metabolic process
HPY07_03160	COG0037	tRNA processing
HPY07_03170	COG3479	Phenolic acid decarboxylase
HPY07_03175	COG0347	Belongs to the P(II) protein family
HPY07_03180	COG3021	interspecies interaction between organisms
HPY07_03185	COG0741	lytic transglycosylase activity
HPY07_03185	COG1388	LysM domain
HPY07_03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY07_03195	COG2226	methyltransferase
HPY07_03200	COG0328	RNA-DNA hybrid ribonuclease activity
HPY07_03215	COG1960	acyl-CoA dehydrogenase activity
HPY07_03220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY07_03225	COG0121	glutamine amidotransferase
HPY07_03230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY07_03235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY07_03240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY07_03245	COG3706	GGDEF domain
HPY07_03250	COG1187	pseudouridine synthase activity
HPY07_03255	COG2840	Smr protein MutS2
HPY07_03285	COG2217	Heavy metal translocating P-type atpase
HPY07_03285	COG2608	mercury ion transmembrane transporter activity
HPY07_03290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY07_03305	COG4774	siderophore transport
HPY07_03305	COG1629	transport
HPY07_03310	COG2375	cellular response to nickel ion
HPY07_03315	COG2226	methyltransferase
HPY07_03315	COG3433	isochorismatase activity
HPY07_03315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY07_03350	COG0835	chemotaxis
HPY07_03350	COG0784	Response regulator, receiver
HPY07_03355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY07_03360	COG1815	bacterial-type flagellum-dependent cell motility
HPY07_03375	COG1749	Flagellar hook protein flgE
HPY07_03380	COG4787	bacterial-type flagellum-dependent cell motility
HPY07_03390	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY07_03395	COG1706	bacterial-type flagellum-dependent cell motility
HPY07_03400	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY07_03400	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY07_03415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY07_03420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY07_03505	COG0012	GTP binding
HPY07_03510	COG0193	aminoacyl-tRNA hydrolase activity
HPY07_03515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY07_03520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY07_03525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY07_03530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY07_03535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY07_03540	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY07_03550	COG2912	Transglutaminase-like superfamily
HPY07_03555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY07_03560	COG0737	Belongs to the 5'-nucleotidase family
HPY07_03565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY07_03570	COG2233	PERMEase
HPY07_03590	COG1393	Belongs to the ArsC family
HPY07_03595	COG4783	chaperone-mediated protein folding
HPY07_03615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY07_03630	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY07_03640	COG1876	peptidase activity
HPY07_03650	COG1393	Belongs to the ArsC family
HPY07_03670	COG2837	iron assimilation
HPY07_03675	COG2706	6-phosphogluconolactonase activity
HPY07_03685	COG0800	Aldolase
HPY07_03695	COG4145	pantothenate transmembrane transporter activity
HPY07_03705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPY07_03715	COG1737	Transcriptional regulator
HPY07_03715	COG0837	glucose binding
HPY07_03720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY07_03725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY07_03730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY07_03735	COG1334	flagellar protein FlaG
HPY07_03740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY07_03750	COG1516	flagellar protein fliS
HPY07_03760	COG4191	Histidine kinase
HPY07_03770	COG1677	Flagellar hook-basal body complex protein FliE
HPY07_03780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY07_03785	COG1317	bacterial-type flagellum organization
HPY07_03810	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY07_03835	COG1987	bacterial-type flagellum assembly
HPY07_03840	COG1684	flagellar biosynthetic protein fliR
HPY07_03850	COG2840	Smr protein MutS2
HPY07_03855	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY07_03860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY07_03865	COG2860	membrane
HPY07_03870	COG3101	peptidyl-lysine hydroxylation
HPY07_03880	COG0431	NADPH-dependent FMN reductase
HPY07_03885	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY07_03885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY07_03890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY07_03895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY07_03900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY07_03905	COG0735	belongs to the Fur family
HPY07_03915	COG0583	DNA-binding transcription factor activity
HPY07_03925	COG1346	cytolysis
HPY07_03940	COG0596	Alpha beta hydrolase
HPY07_03945	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY07_03950	COG0033	Phosphoglucomutase
HPY07_03960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY07_03965	COG0372	Belongs to the citrate synthase family
HPY07_03970	COG2009	succinate dehydrogenase
HPY07_03975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY07_03980	COG1053	succinate dehydrogenase
HPY07_03990	COG0567	Dehydrogenase, E1 component
HPY07_03995	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY07_04000	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY07_04010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY07_04015	COG1121	(ABC) transporter
HPY07_04020	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY07_04025	COG4977	sequence-specific DNA binding
HPY07_04030	COG1918	ferrous iron import across plasma membrane
HPY07_04050	COG0018	arginyl-trna synthetase
HPY07_04060	COG1025	Belongs to the peptidase M16 family
HPY07_04065	COG2062	phosphohistidine phosphatase, SixA
HPY07_04095	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY07_04100	COG2198	Histidine kinase
HPY07_04100	COG0643	Histidine kinase
HPY07_04100	COG0784	Response regulator, receiver
HPY07_04105	COG2201	protein-glutamate methylesterase activity
HPY07_04110	COG1192	Involved in chromosome partitioning
HPY07_04120	COG0835	chemotaxis
HPY07_04130	COG4133	protoheme IX ABC transporter activity
HPY07_04135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY07_04140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY07_04150	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY07_04155	COG1138	Cytochrome C-type biogenesis protein
HPY07_04160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY07_04165	COG3088	subunit of a heme lyase
HPY07_04165	COG4235	cytochrome complex assembly
HPY07_04175	COG2853	Lipoprotein
HPY07_04195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY07_04200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY07_04205	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY07_04220	COG3083	sulfuric ester hydrolase activity
HPY07_04225	COG3082	Protein of unknown function (DUF1414)
HPY07_04230	COG3081	Nucleoid-associated protein
HPY07_04240	COG1757	Na H antiporter
HPY07_04245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY07_04250	COG2095	MarC family integral membrane protein
HPY07_04255	COG1012	belongs to the aldehyde dehydrogenase family
HPY07_04255	COG1454	alcohol dehydrogenase
HPY07_04265	COG0659	secondary active sulfate transmembrane transporter activity
HPY07_04270	COG1530	ribonuclease E activity
HPY07_04275	COG0564	pseudouridine synthase activity
HPY07_04280	COG0424	maF-like protein
HPY07_04285	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY07_04290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY07_04295	COG0416	fatty acid biosynthetic process
HPY07_04300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY07_04310	COG1028	Short-chain dehydrogenase reductase Sdr
HPY07_04315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY07_04320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY07_04325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY07_04330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY07_04335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY07_04345	COG0084	hydrolase, TatD family'
HPY07_04350	COG1263	PTS System
HPY07_04350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY07_04360	COG0733	neurotransmitter:sodium symporter activity
HPY07_04375	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY07_04385	COG1940	carbohydrate kinase activity
HPY07_04390	COG0784	Response regulator, receiver
HPY07_04390	COG0835	chemotaxis
HPY07_04405	COG2226	methyltransferase
HPY07_04415	COG0676	glucose-6-phosphate 1-epimerase activity
HPY07_04420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY07_04425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY07_04435	COG3139	Protein of unknown function (DUF1315)
HPY07_04440	COG0252	asparaginase activity
HPY07_04445	COG0616	signal peptide processing
HPY07_04450	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY07_04450	COG1902	pentaerythritol trinitrate reductase activity
HPY07_04455	COG0788	formyltetrahydrofolate deformylase activity
HPY07_04465	COG1199	ATP-dependent helicase activity
HPY07_04470	COG1214	PFAM Peptidase M22, glycoprotease
HPY07_04485	COG0596	Alpha beta hydrolase
HPY07_04490	COG0318	PFAM AMP-dependent synthetase and ligase
HPY07_04495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY07_04510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY07_04515	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY07_04520	COG0436	Aminotransferase
HPY07_04525	COG1169	isochorismate synthase
HPY07_04530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY07_04535	COG0596	Alpha beta hydrolase
HPY07_04555	COG3135	benzoate transporter
HPY07_04580	COG3015	lipoprotein NlpE involved in copper resistance
HPY07_04585	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY07_04590	COG2894	cell division
HPY07_04595	COG0850	regulation of cytokinetic process
HPY07_04600	COG3100	YcgL domain-containing protein
HPY07_04605	COG2951	lytic endotransglycosylase activity
HPY07_04615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY07_04620	COG3005	denitrification pathway
HPY07_04625	COG0243	molybdopterin cofactor binding
HPY07_04640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY07_04655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY07_04690	COG4589	Belongs to the CDS family
HPY07_04700	COG5001	Diguanylate cyclase
HPY07_04700	COG3300	MHYT domain
HPY07_04710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY07_04715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY07_04720	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY07_04725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY07_04735	COG4191	Histidine kinase
HPY07_04745	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY07_04755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY07_04760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY07_04765	COG0776	regulation of translation
HPY07_04770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY07_04775	COG1555	photosystem II stabilization
HPY07_04780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY07_04785	COG0539	negative regulation of cytoplasmic translation
HPY07_04790	COG0776	regulation of translation
HPY07_04795	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY07_04800	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY07_04820	COG0583	DNA-binding transcription factor activity
HPY07_04830	COG0686	Belongs to the AlaDH PNT family
HPY07_04840	COG1674	ftsk spoiiie
HPY07_04845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY07_04850	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY07_04855	COG2186	Transcriptional regulator
HPY07_04870	COG0537	adenosine 5'-monophosphoramidase activity
HPY07_04895	COG3150	esterase
HPY07_04900	COG1252	NADH dehydrogenase
HPY07_04925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY07_04935	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY07_04940	COG1136	(ABC) transporter
HPY07_04945	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY07_04955	COG0658	competence protein
HPY07_04955	COG2333	competence protein COMEC
HPY07_04960	COG1132	(ABC) transporter
HPY07_04965	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY07_04970	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY07_04975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY07_04980	COG2719	SpoVR family
HPY07_04985	COG2718	Belongs to the UPF0229 family
HPY07_04990	COG2766	serine protein kinase
HPY07_04995	COG3013	Belongs to the UPF0304 family
HPY07_05005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY07_05010	COG0840	transmembrane signaling receptor activity
HPY07_05020	COG1882	Formate acetyltransferase
HPY07_05045	COG4160	amino acid transport
HPY07_05050	COG0708	Exodeoxyribonuclease III
HPY07_05060	COG3923	Primosomal replication protein n
HPY07_05065	COG0730	response to heat
HPY07_05070	COG1199	ATP-dependent helicase activity
HPY07_05080	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY07_05085	COG3012	SEC-C Motif Domain Protein
HPY07_05090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY07_05095	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY07_05100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY07_05105	COG0215	cysteine-tRNA ligase activity
HPY07_05110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY07_05115	COG0632	four-way junction helicase activity
HPY07_05125	COG1271	oxidase subunit
HPY07_05130	COG1294	oxidase, subunit
HPY07_05135	COG4890	Cyd operon protein YbgT
HPY07_05140	COG3790	cyd operon protein YbgE
HPY07_05145	COG0824	Thioesterase
HPY07_05150	COG0811	peptide transport
HPY07_05165	COG0823	Involved in the tonB-independent uptake of proteins
HPY07_05170	COG2885	chlorophyll binding
HPY07_05180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY07_05190	COG5002	protein histidine kinase activity
HPY07_05190	COG0784	Response regulator, receiver
HPY07_05200	COG1482	cell wall glycoprotein biosynthetic process
HPY07_05205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY07_05205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY07_05205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY07_05210	COG2207	Transcriptional regulator
HPY07_05220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY07_05225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY07_05230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY07_05240	COG1012	belongs to the aldehyde dehydrogenase family
HPY07_05245	COG3284	Transcriptional regulator
HPY07_05250	COG4628	conserved protein (DUF2132)
HPY07_05260	COG0415	Belongs to the DNA photolyase family
HPY07_05315	COG2003	Belongs to the UPF0758 family
HPY07_05325	COG4409	exo-alpha-(2->6)-sialidase activity
HPY07_05330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY07_05335	COG1940	carbohydrate kinase activity
HPY07_05345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY07_05350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY07_05355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY07_05360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPY07_05365	COG1737	Transcriptional regulator
HPY07_05370	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY07_05375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY07_05385	COG5492	domain, Protein
HPY07_05385	COG4932	domain protein
HPY07_05410	COG0596	Alpha beta hydrolase
HPY07_05420	COG3064	Membrane
HPY07_05525	COG4789	Type iii secretion
HPY07_05530	COG4792	protein secretion
HPY07_05560	COG3710	Transcriptional regulator
HPY07_05570	COG4790	Type iii secretion
HPY07_05650	COG0582	viral genome integration into host DNA
HPY07_05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY07_05675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY07_05675	COG3008	intermembrane lipid transfer
HPY07_05680	COG2995	paraquat-inducible protein a
HPY07_05685	COG0668	transmembrane transport
HPY07_05705	COG1309	transcriptional regulator
HPY07_05710	COG1012	belongs to the aldehyde dehydrogenase family
HPY07_05735	COG1960	acyl-CoA dehydrogenase activity
HPY07_05740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY07_05745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY07_05750	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY07_05755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY07_05770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY07_05775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY07_05780	COG0297	glycogen (starch) synthase activity
HPY07_05800	COG3070	regulator of competence-specific genes
HPY07_05805	COG1609	Transcriptional regulator
HPY07_05810	COG3381	protein complex oligomerization
HPY07_05815	COG0745	RESPONSE REGULATOR receiver
HPY07_05820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY07_05825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY07_05830	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY07_05835	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY07_05850	COG1280	lysine exporter protein (LysE YggA)
HPY07_05855	COG1032	radical SAM domain protein
HPY07_05860	COG5001	Diguanylate cyclase
HPY07_05865	COG0612	Peptidase, M16
HPY07_05880	COG0583	DNA-binding transcription factor activity
HPY07_05885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY07_05895	COG2350	Protein conserved in bacteria
HPY07_05900	COG1607	acyl-coa hydrolase
HPY07_05915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY07_05920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY07_05930	COG2116	formate transmembrane transporter activity
HPY07_05935	COG4459	periplasmic nitrate reductase
HPY07_05940	COG3005	denitrification pathway
HPY07_05945	COG0243	molybdopterin cofactor binding
HPY07_05965	COG1227	inorganic diphosphatase activity
HPY07_05995	COG4172	Belongs to the ABC transporter superfamily
HPY07_06010	COG4168	peptide transport system, permease
HPY07_06020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY07_06025	COG1842	Phage shock protein A
HPY07_06040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY07_06055	COG2818	Glycosylase
HPY07_06060	COG0626	cystathionine gamma-synthase activity
HPY07_06070	COG0733	neurotransmitter:sodium symporter activity
HPY07_06075	COG0564	pseudouridine synthase activity
HPY07_06080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY07_06085	COG4136	ATPase activity
HPY07_06090	COG4135	transport system, permease component
HPY07_06095	COG4134	Bacterial extracellular solute-binding protein
HPY07_06105	COG3313	Fe-S protein
HPY07_06115	COG0814	amino acid
HPY07_06125	COG2239	Acts as a magnesium transporter
HPY07_06130	COG0784	Response regulator, receiver
HPY07_06130	COG2205	protein histidine kinase activity
HPY07_06145	COG4934	collagen metabolic process
HPY07_06180	COG0840	transmembrane signaling receptor activity
HPY07_06190	COG5001	Diguanylate cyclase
HPY07_06190	COG4251	negative regulation of phosphorylation
HPY07_06190	COG3706	GGDEF domain
HPY07_06190	COG2203	Gaf domain
HPY07_06195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY07_06200	COG5002	protein histidine kinase activity
HPY07_06215	COG1061	Type III restriction enzyme res subunit
HPY07_06220	COG1187	pseudouridine synthase activity
HPY07_06225	COG2814	Major facilitator Superfamily
HPY07_06235	COG0702	epimerase
HPY07_06240	COG0534	Mate efflux family protein
HPY07_06245	COG4181	ATPase activity
HPY07_06260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY07_06270	COG1748	Saccharopine dehydrogenase
HPY07_06295	COG1538	Outer membrane efflux protein
HPY07_06315	COG0583	DNA-binding transcription factor activity
HPY07_06325	COG1451	nucleotide metabolic process
HPY07_06340	COG3063	Type IV pilus biogenesis stability protein PilW
HPY07_06345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY07_06365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY07_06380	COG3290	protein histidine kinase activity
HPY07_06385	COG4565	transcriptional regulatory protein
HPY07_06395	COG0835	chemotaxis
HPY07_06395	COG0784	Response regulator, receiver
HPY07_06445	COG1085	galactose-1-phosphate uridylyltransferase
HPY07_06450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY07_06455	COG2017	converts alpha-aldose to the beta-anomer
HPY07_06460	COG3706	GGDEF domain
HPY07_06465	COG2199	diguanylate cyclase activity
HPY07_06465	COG2200	EAL domain
HPY07_06480	COG3527	Alpha-acetolactate decarboxylase
HPY07_06490	COG3064	Membrane
HPY07_06500	COG0753	catalase activity
HPY07_06520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY07_06570	COG1271	oxidase subunit
HPY07_06575	COG1294	oxidase, subunit
HPY07_06580	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY07_06580	COG1136	(ABC) transporter
HPY07_06585	COG0577	efflux transmembrane transporter activity
HPY07_06585	COG1136	(ABC) transporter
HPY07_06590	COG1136	(ABC) transporter
HPY07_06590	COG0577	efflux transmembrane transporter activity
HPY07_06615	COG2816	NAD+ diphosphatase activity
HPY07_06620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY07_06635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY07_06645	COG2723	6-phospho-beta-galactosidase activity
HPY07_06650	COG1609	Transcriptional regulator
HPY07_06655	COG0251	oxidation-reduction process
HPY07_06660	COG2731	YhcH YjgK YiaL family protein
HPY07_06665	COG0584	glycerophosphoryl diester phosphodiesterase
HPY07_06670	COG1349	DNA-binding transcription factor activity
HPY07_06675	COG3842	ATPase activity
HPY07_06680	COG0395	ABC-type sugar transport system, permease component
HPY07_06685	COG1175	transmembrane transport
HPY07_06700	COG0811	peptide transport
HPY07_06705	COG0811	peptide transport
HPY07_06710	COG0848	biopolymer transport protein
HPY07_06715	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY07_06725	COG1793	dna ligase
HPY07_06735	COG0534	Mate efflux family protein
HPY07_06745	COG3001	Fructosamine kinase
HPY07_06755	COG0791	NLP P60 protein
HPY07_06760	COG0840	transmembrane signaling receptor activity
HPY07_06775	COG1940	carbohydrate kinase activity
HPY07_06795	COG0746	molybdenum cofactor guanylyltransferase activity
HPY07_06800	COG3842	ATPase activity
HPY07_06805	COG4662	Binding-protein-dependent transport system inner membrane component
HPY07_06815	COG2204	response regulator
HPY07_06820	COG3852	Histidine kinase
HPY07_06825	COG0488	(ABC) transporter
HPY07_06830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY07_06860	COG0243	molybdopterin cofactor binding
HPY07_06860	COG3383	formate dehydrogenase (NAD+) activity
HPY07_06865	COG0437	4 iron, 4 sulfur cluster binding
HPY07_06880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY07_06885	COG1666	GTP binding
HPY07_06890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY07_06905	COG2996	Protein conserved in bacteria
HPY07_06920	COG2995	paraquat-inducible protein a
HPY07_06925	COG1132	(ABC) transporter
HPY07_06930	COG1956	GAF domain-containing protein
HPY07_06935	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY07_06950	COG0308	aminopeptidase N
HPY07_06965	COG0167	dihydroorotate dehydrogenase activity
HPY07_06975	COG0116	Belongs to the methyltransferase superfamily
HPY07_06975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY07_07000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY07_07005	COG1067	ATP-dependent peptidase activity
HPY07_07010	COG3120	sequence-specific DNA binding
HPY07_07090	COG3064	Membrane
HPY07_07090	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY07_07090	COG1073	alpha beta
HPY07_07095	COG2994	toxin metabolic process
HPY07_07120	COG2205	protein histidine kinase activity
HPY07_07120	COG0784	Response regulator, receiver
HPY07_07135	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY07_07150	COG2010	Cytochrome c
HPY07_07160	COG2217	Heavy metal translocating P-type atpase
HPY07_07175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY07_07180	COG0589	response to stress
HPY07_07185	COG0037	tRNA processing
HPY07_07205	COG3842	ATPase activity
HPY07_07215	COG1177	transmembrane transport
HPY07_07225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY07_07235	COG1115	amino acid carrier protein
HPY07_07240	COG1280	lysine exporter protein (LysE YggA)
HPY07_07270	COG3501	Rhs element vgr protein
HPY07_07280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY07_07285	COG0513	Belongs to the DEAD box helicase family
HPY07_07290	COG2076	Multidrug Resistance protein
HPY07_07295	COG0415	Belongs to the DNA photolyase family
HPY07_07300	COG0477	Major facilitator Superfamily
HPY07_07305	COG0583	DNA-binding transcription factor activity
HPY07_07315	COG0402	S-adenosylhomocysteine deaminase activity
HPY07_07320	COG0095	Lipoate-protein ligase
HPY07_07325	COG0443	Heat shock 70 kDa protein
HPY07_07335	COG1643	Atp-dependent helicase
HPY07_07365	COG0443	Heat shock 70 kDa protein
HPY07_07370	COG0443	Heat shock 70 kDa protein
HPY07_07375	COG3706	GGDEF domain
HPY07_07405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY07_07410	COG0602	queuosine metabolic process
HPY07_07415	COG0561	phosphatase activity
HPY07_07425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY07_07430	COG4597	amino acid ABC transporter
HPY07_07435	COG0765	amino acid transport
HPY07_07440	COG1126	abc transporter atp-binding protein
HPY07_07445	COG0670	Belongs to the BI1 family
HPY07_07450	COG2920	part of a sulfur-relay system
HPY07_07455	COG1254	Belongs to the acylphosphatase family
HPY07_07465	COG3706	GGDEF domain
HPY07_07475	COG2205	protein histidine kinase activity
HPY07_07475	COG3437	response regulator, receiver
HPY07_07475	COG3850	Histidine kinase
HPY07_07475	COG4999	Histidine kinase
HPY07_07480	COG3437	response regulator, receiver
HPY07_07485	COG0625	glutathione transferase activity
HPY07_07495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY07_07505	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY07_07530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY07_07620	COG0372	Belongs to the citrate synthase family
HPY07_07625	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY07_07650	COG0583	DNA-binding transcription factor activity
HPY07_07655	COG4771	TonB-dependent receptor
HPY07_07680	COG1566	PFAM secretion protein HlyD family protein
HPY07_07700	COG1129	ABC transporter
HPY07_07725	COG0745	RESPONSE REGULATOR receiver
HPY07_07730	COG2205	protein histidine kinase activity
HPY07_07735	COG3713	MltA-interacting MipA family protein
HPY07_07740	COG2990	Protein conserved in bacteria
HPY07_07750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY07_07750	COG4191	Histidine kinase
HPY07_07755	COG0471	metal ion transport
HPY07_07765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY07_07780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_07790	COG3768	UPF0283 membrane protein
HPY07_07795	COG3106	COG3106 Predicted ATPase
HPY07_07810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY07_07815	COG0494	nUDIX hydrolase
HPY07_07820	COG0814	amino acid
HPY07_07825	COG1760	l-serine dehydratase
HPY07_07830	COG0720	synthase
HPY07_07835	COG0840	transmembrane signaling receptor activity
HPY07_07840	COG0017	Asparaginyl-tRNA synthetase
HPY07_07845	COG0351	phosphomethylpyrimidine kinase
HPY07_07850	COG3437	response regulator, receiver
HPY07_07850	COG2770	Histidine kinase
HPY07_07855	COG1448	Aminotransferase
HPY07_07870	COG0840	transmembrane signaling receptor activity
HPY07_07875	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY07_07880	COG2943	transferase activity, transferring hexosyl groups
HPY07_07885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY07_07890	COG1846	Transcriptional regulator
HPY07_07915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY07_07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY07_07935	COG3108	Peptidase M15
HPY07_07970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY07_07980	COG2814	Major facilitator Superfamily
HPY07_08000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY07_08005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY07_08010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY07_08040	COG0840	transmembrane signaling receptor activity
HPY07_08055	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY07_08060	COG4139	cobalamin transport
HPY07_08065	COG2988	succinylglutamate desuccinylase activity
HPY07_08080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY07_08085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY07_08090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY07_08100	COG2925	Exonuclease
HPY07_08105	COG1380	Effector of murein hydrolase LrgA
HPY07_08110	COG1346	cytolysis
HPY07_08140	COG0776	regulation of translation
HPY07_08145	COG0072	phenylalanine-tRNA ligase activity
HPY07_08145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY07_08150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY07_08190	COG0322	excinuclease ABC activity
HPY07_08195	COG2197	response regulator
HPY07_08200	COG0417	DNA replication proofreading
HPY07_08205	COG5001	Diguanylate cyclase
HPY07_08215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY07_08220	COG3099	Belongs to the UPF0263 family
HPY07_08235	COG1228	amidohydrolase
HPY07_08240	COG0010	Belongs to the arginase family
HPY07_08245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY07_08250	COG2986	histidine ammonia-lyase
HPY07_08270	COG0247	lactate metabolic process
HPY07_08270	COG0277	FAD linked oxidase domain protein
HPY07_08285	COG2885	chlorophyll binding
HPY07_08305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY07_08315	COG0281	malic enzyme
HPY07_08325	COG2949	membrane
HPY07_08330	COG3706	GGDEF domain
HPY07_08335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY07_08345	COG0492	ferredoxin-NADP+ reductase activity
HPY07_08350	COG4988	ABC transporter
HPY07_08355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY07_08360	COG1187	pseudouridine synthase activity
HPY07_08365	COG0009	L-threonylcarbamoyladenylate synthase
HPY07_08370	COG0613	PHP domain protein
HPY07_08380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY07_08385	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY07_08390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY07_08395	COG0135	phosphoribosylanthranilate isomerase activity
HPY07_08395	COG0134	indole-3-glycerol-phosphate synthase activity
HPY07_08400	COG0133	tryptophan synthase activity
HPY07_08405	COG0159	tryptophan synthase activity
HPY07_08415	COG1435	thymidine kinase activity
HPY07_08420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY07_08425	COG1801	Protein of unknown function DUF72
HPY07_08430	COG4106	trans-aconitate 2-methyltransferase activity
HPY07_08435	COG0500	methyltransferase
HPY07_08440	COG4067	protein conserved in archaea
HPY07_08440	COG0189	ligase activity
HPY07_08455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY07_08465	COG3852	Histidine kinase
HPY07_08480	COG3070	regulator of competence-specific genes
HPY07_08490	COG2431	L-lysine efflux transmembrane transporter activity
HPY07_08500	COG0076	glutamate decarboxylase activity
HPY07_08505	COG1737	Transcriptional regulator
HPY07_08510	COG1012	belongs to the aldehyde dehydrogenase family
HPY07_08510	COG1454	alcohol dehydrogenase
HPY07_08515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY07_08520	COG3273	potassium ion transport
HPY07_08520	COG2985	domain, Protein
HPY07_08525	COG0542	response to heat
HPY07_08530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY07_08535	COG1278	Cold shock
HPY07_08545	COG1187	pseudouridine synthase activity
HPY07_08550	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY07_08550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY07_08555	COG0107	imidazoleglycerol-phosphate synthase activity
HPY07_08560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY07_08565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY07_08570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY07_08570	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY07_08575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY07_08580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY07_08585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY07_08590	COG1757	Na H antiporter
HPY07_08595	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY07_08600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY07_08605	COG0482	sulfurtransferase activity
HPY07_08610	COG2915	High frequency lysogenization protein hflD homolog
HPY07_08615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY07_08625	COG2268	Band 7 protein
HPY07_08635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY07_08650	COG0300	oxidoreductase activity
HPY07_08660	COG0501	Belongs to the peptidase M48B family
HPY07_08670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY07_08675	COG2226	methyltransferase
HPY07_08680	COG0156	8-amino-7-oxononanoate synthase activity
HPY07_08685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY07_08690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY07_08695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY07_08700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY07_08705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY07_08710	COG0653	protein targeting
HPY07_08715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY07_08720	COG3706	GGDEF domain
HPY07_08730	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY07_08740	COG4628	conserved protein (DUF2132)
HPY07_08745	COG3092	negative regulation of chromosome organization
HPY07_08750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY07_08755	COG0857	belongs to the CobB CobQ family
HPY07_08755	COG0280	phosphate acetyltransferase
HPY07_08760	COG0435	Glutathione S-transferase
HPY07_08765	COG4608	Belongs to the ABC transporter superfamily
HPY07_08770	COG0444	Belongs to the ABC transporter superfamily
HPY07_08775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY07_08780	COG0601	transmembrane transport
HPY07_08800	COG2204	response regulator
HPY07_08805	COG5001	Diguanylate cyclase
HPY07_08805	COG3300	MHYT domain
HPY07_08810	COG4191	Histidine kinase
HPY07_08815	COG5002	protein histidine kinase activity
HPY07_08825	COG2201	protein-glutamate methylesterase activity
HPY07_08840	COG0009	L-threonylcarbamoyladenylate synthase
HPY07_08855	COG1881	PFAM PEBP family protein
HPY07_08880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY07_08885	COG0640	Transcriptional regulator
HPY07_08895	COG3706	GGDEF domain
HPY07_08915	COG1946	Acyl-CoA thioesterase
HPY07_08920	COG1522	sequence-specific DNA binding
HPY07_08925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY07_08930	COG0616	signal peptide processing
HPY07_08935	COG1028	Short-chain dehydrogenase reductase Sdr
HPY07_08945	COG2983	Belongs to the UPF0260 family
HPY07_08955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY07_08960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY07_08965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY07_08970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY07_08975	COG2832	Protein of unknown function (DUF454)
HPY07_08980	COG0745	RESPONSE REGULATOR receiver
HPY07_08985	COG0583	DNA-binding transcription factor activity
HPY07_08990	COG0778	Nitroreductase
HPY07_08995	COG1024	Enoyl-CoA hydratase
HPY07_08995	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY07_09000	COG0183	Belongs to the thiolase family
HPY07_09015	COG2067	long-chain fatty acid transport protein
HPY07_09025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY07_09030	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY07_09035	COG2982	Protein involved in outer membrane biogenesis
HPY07_09040	COG0572	uridine kinase
HPY07_09045	COG0489	protein tyrosine kinase activity
HPY07_09050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY07_09050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY07_09060	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY07_09070	COG0517	IMP dehydrogenase activity
HPY07_09070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY07_09070	COG0617	tRNA 3'-terminal CCA addition
HPY07_09075	COG2199	diguanylate cyclase activity
HPY07_09080	COG0314	molybdopterin synthase activity
HPY07_09085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY07_09090	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY07_09095	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY07_09100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY07_09105	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY07_09110	COG2198	Histidine kinase
HPY07_09115	COG2204	response regulator
HPY07_09120	COG0556	nucleotide-excision repair
HPY07_09130	COG4657	Part of a membrane complex involved in electron transport
HPY07_09135	COG2878	Part of a membrane complex involved in electron transport
HPY07_09140	COG4656	Part of a membrane complex involved in electron transport
HPY07_09155	COG4660	Part of a membrane complex involved in electron transport
HPY07_09160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY07_09165	COG0346	lactoylglutathione lyase activity
HPY07_09180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY07_09185	COG2056	Na+-H+ antiporter family
HPY07_09190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY07_09195	COG1286	toxin biosynthetic process
HPY07_09200	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY07_09205	COG0285	dihydrofolate synthase activity
HPY07_09210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY07_09215	COG0101	tRNA pseudouridine synthase activity
HPY07_09230	COG1263	PTS System
HPY07_09230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY07_09230	COG2190	(PTS) system
HPY07_09235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY07_09240	COG1940	carbohydrate kinase activity
HPY07_09240	COG1846	Transcriptional regulator
HPY07_09245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY07_09245	COG4651	solute:proton antiporter activity
HPY07_09250	COG0367	asparagine synthase
HPY07_09260	COG3104	oligopeptide transport
HPY07_09265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY07_09270	COG0563	adenylate kinase activity
HPY07_09275	COG0326	Molecular chaperone. Has ATPase activity
HPY07_09280	COG3710	Transcriptional regulator
HPY07_09295	COG0622	Phosphoesterase
HPY07_09300	COG1090	epimerase
HPY07_09305	COG0300	oxidoreductase activity
HPY07_09310	COG3118	belongs to the thioredoxin family
HPY07_09315	COG0330	HflC and HflK could
HPY07_09320	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY07_09325	COG0789	Transcriptional regulator
HPY07_09340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY07_09345	COG3115	cell septum assembly
HPY07_09350	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY07_09355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY07_09360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY07_09370	COG2190	(PTS) system
HPY07_09375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY07_09380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY07_09385	COG1702	phosphate starvation-inducible protein PhoH
HPY07_09390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY07_09395	COG4535	Mg2 and Co2 transporter CorC
HPY07_09400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY07_09405	COG2888	peptidyl-tyrosine sulfation
HPY07_09410	COG0495	leucyl-tRNA aminoacylation
HPY07_09415	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY07_09420	COG1466	dna polymerase III delta subunit
HPY07_09425	COG0799	negative regulation of ribosome biogenesis
HPY07_09430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY07_09435	COG0768	penicillin binding
HPY07_09440	COG0772	Belongs to the SEDS family
HPY07_09445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY07_09450	COG1686	Belongs to the peptidase S11 family
HPY07_09455	COG2921	Belongs to the UPF0250 family
HPY07_09460	COG0321	lipoyl(octanoyl) transferase activity
HPY07_09465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY07_09475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY07_09500	COG1596	polysaccharide export
HPY07_09510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY07_09540	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY07_09550	COG0438	transferase activity, transferring glycosyl groups
HPY07_09560	COG1045	serine acetyltransferase
HPY07_09580	COG0110	maltose O-acetyltransferase activity
HPY07_09585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY07_09590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY07_09595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY07_09600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY07_09630	COG0366	Alpha amylase catalytic
HPY07_09635	COG1263	PTS System
HPY07_09635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY07_09640	COG1609	Transcriptional regulator
HPY07_09645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY07_09650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY07_09655	COG2011	ABC-type metal ion transport system permease component
HPY07_09660	COG1464	Belongs to the NlpA lipoprotein family
HPY07_09665	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY07_09675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY07_09675	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY07_09685	COG3706	GGDEF domain
HPY07_09690	COG1611	Belongs to the LOG family
HPY07_09695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY07_09700	COG2363	Small membrane protein
HPY07_09705	COG0583	DNA-binding transcription factor activity
HPY07_09710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY07_09710	COG0301	tRNA thio-modification
HPY07_09720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY07_09725	COG1722	exodeoxyribonuclease VII activity
HPY07_09730	COG0142	geranyltranstransferase activity
HPY07_09735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY07_09740	COG0564	pseudouridine synthase activity
HPY07_09745	COG3098	single-species biofilm formation
HPY07_09760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_09770	COG1671	Belongs to the UPF0178 family
HPY07_09775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY07_09780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY07_09785	COG0254	rRNA binding
HPY07_09790	COG1720	tRNA m6t6A37 methyltransferase activity
HPY07_09795	COG0442	prolyl-tRNA aminoacylation
HPY07_09815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY07_09815	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY07_09820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY07_09830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY07_09860	COG0484	heat shock protein binding
HPY07_09865	COG0443	Heat shock 70 kDa protein
HPY07_09870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY07_09875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY07_09880	COG0497	DNA recombination
HPY07_09885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY07_09890	COG2914	Belongs to the UPF0125 (RnfH) family
HPY07_09895	COG2867	negative regulation of translational initiation
HPY07_09900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY07_09950	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY07_09955	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY07_09960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY07_09980	COG3051	citrate lyase alpha subunit
HPY07_09985	COG2301	Belongs to the HpcH HpaI aldolase family
HPY07_09995	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY07_10005	COG3630	sodium ion export across plasma membrane
HPY07_10010	COG5016	pyruvate
HPY07_10010	COG0511	ligase activity, forming carbon-carbon bonds
HPY07_10015	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY07_10025	COG4565	transcriptional regulatory protein
HPY07_10050	COG1115	amino acid carrier protein
HPY07_10060	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY07_10065	COG0583	DNA-binding transcription factor activity
HPY07_10075	COG1120	ATPase activity
HPY07_10080	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY07_10085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY07_10090	COG4592	Periplasmic binding protein
HPY07_10100	COG1028	Short-chain dehydrogenase reductase Sdr
HPY07_10105	COG1169	isochorismate synthase
HPY07_10110	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY07_10115	COG3433	isochorismatase activity
HPY07_10115	COG1535	isochorismatase
HPY07_10120	COG1584	GPR1 FUN34 yaaH family protein
HPY07_10130	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY07_10140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY07_10140	COG0519	Catalyzes the synthesis of GMP from XMP
HPY07_10145	COG0517	IMP dehydrogenase activity
HPY07_10145	COG0516	GMP reductase activity
HPY07_10150	COG1570	exodeoxyribonuclease VII activity
HPY07_10165	COG1160	GTP binding
HPY07_10170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY07_10175	COG2976	Protein conserved in bacteria
HPY07_10180	COG0124	histidyl-tRNA synthetase
HPY07_10185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY07_10200	COG0105	UTP biosynthetic process
HPY07_10205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY07_10210	COG2975	iron-sulfur cluster assembly
HPY07_10215	COG0633	Ferredoxin
HPY07_10235	COG0822	iron-sulfur transferase activity
HPY07_10245	COG1959	2 iron, 2 sulfur cluster binding
HPY07_10255	COG0483	inositol monophosphate 1-phosphatase activity
HPY07_10260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY07_10265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY07_10270	COG1862	Preprotein translocase
HPY07_10280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY07_10285	COG0517	IMP dehydrogenase activity
HPY07_10295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY07_10300	COG0583	DNA-binding transcription factor activity
HPY07_10305	COG0450	alkyl hydroperoxide reductase
HPY07_10310	COG3142	Participates in the control of copper homeostasis
HPY07_10325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY07_10330	COG0581	inorganic phosphate transmembrane transporter activity
HPY07_10340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY07_10345	COG0248	Ppx GppA phosphatase
HPY07_10355	COG5002	protein histidine kinase activity
HPY07_10360	COG0745	RESPONSE REGULATOR receiver
HPY07_10375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY07_10420	COG0542	response to heat
HPY07_10430	COG0564	pseudouridine synthase activity
HPY07_10435	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY07_10440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY07_10445	COG1605	Chorismate mutase
HPY07_10445	COG0077	Prephenate dehydratase
HPY07_10450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY07_10455	COG5001	Diguanylate cyclase
HPY07_10465	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY07_10475	COG0488	(ABC) transporter
HPY07_10485	COG0287	Prephenate dehydrogenase
HPY07_10485	COG1605	Chorismate mutase
HPY07_10490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY07_10495	COG3275	phosphorelay sensor kinase activity
HPY07_10500	COG3279	Response regulator of the LytR AlgR family
HPY07_10510	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY07_10515	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY07_10530	COG1966	Carbon starvation protein
HPY07_10535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY07_10540	COG1047	Peptidyl-prolyl cis-trans
HPY07_10545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY07_10555	COG0196	riboflavin kinase activity
HPY07_10560	COG0728	peptidoglycan biosynthetic process
HPY07_10565	COG0268	Binds directly to 16S ribosomal RNA
HPY07_10570	COG0640	Transcriptional regulator
HPY07_10575	COG0583	DNA-binding transcription factor activity
HPY07_10580	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY07_10590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY07_10595	COG0730	response to heat
HPY07_10600	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY07_10605	COG0494	nUDIX hydrolase
HPY07_10615	COG0667	Aldo Keto reductase
HPY07_10625	COG2204	response regulator
HPY07_10630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY07_10650	COG0513	Belongs to the DEAD box helicase family
HPY07_10675	COG3153	acetyltransferase
HPY07_10680	COG3154	lipid carrier protein
HPY07_10690	COG0826	peptidase U32
HPY07_10695	COG0826	peptidase U32
HPY07_10715	COG1185	polyribonucleotide nucleotidyltransferase activity
HPY07_10720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY07_10730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY07_10735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY07_10740	COG0195	Participates in both transcription termination and antitermination
HPY07_10745	COG0779	Required for maturation of 30S ribosomal subunits
HPY07_10760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY07_10770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY07_10775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY07_10780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY07_10785	COG1534	Rna-binding protein
HPY07_10790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY07_10795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY07_10800	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY07_10805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY07_10810	COG0739	heme binding
HPY07_10825	COG0316	Belongs to the HesB IscA family
HPY07_10830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY07_10835	COG0628	permease
HPY07_10840	COG2813	Specifically methylates the guanine in position
HPY07_10850	COG0747	negative chemotaxis
HPY07_10860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY07_10865	COG0444	Belongs to the ABC transporter superfamily
HPY07_10870	COG4608	Belongs to the ABC transporter superfamily
HPY07_10880	COG2971	BadF BadG BcrA BcrD
HPY07_10900	COG3842	ATPase activity
HPY07_10910	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY07_10915	COG0004	ammonium transporteR
HPY07_10920	COG0347	Belongs to the P(II) protein family
HPY07_10925	COG3112	Uncharacterised protein family (UPF0231)
HPY07_10930	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY07_10935	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY07_10940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY07_10945	COG1643	Atp-dependent helicase
HPY07_10955	COG1489	DNA binding
HPY07_10965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY07_10975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY07_10980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY07_10985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY07_10990	COG0842	Transport permease protein
HPY07_10995	COG1131	(ABC) transporter
HPY07_11000	COG0659	secondary active sulfate transmembrane transporter activity
HPY07_11005	COG0288	reversible hydration of carbon dioxide
HPY07_11020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY07_11025	COG3107	peptidoglycan biosynthetic process
HPY07_11030	COG0792	nuclease activity
HPY07_11035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY07_11040	COG2823	Periplasmic or secreted lipoprotein
HPY07_11045	COG2969	positive regulation of protein catabolic process
HPY07_11050	COG0625	glutathione transferase activity
HPY07_11055	COG2857	Cytochrome c1
HPY07_11060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY07_11065	COG0723	plastoquinol--plastocyanin reductase activity
HPY07_11070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY07_11075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY07_11080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY07_11090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY07_11095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY07_11100	COG0335	large ribosomal subunit rRNA binding
HPY07_11105	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY07_11110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY07_11115	COG0228	four-way junction DNA binding
HPY07_11120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY07_11125	COG4137	Cytochrome C assembly protein
HPY07_11130	COG4536	flavin adenine dinucleotide binding
HPY07_11135	COG1854	S-ribosylhomocysteine lyase activity
HPY07_11140	COG2918	glutathione biosynthetic process
HPY07_11145	COG0612	Peptidase, M16
HPY07_11150	COG1238	metal cluster binding
HPY07_11160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY07_11165	COG0511	ligase activity, forming carbon-carbon bonds
HPY07_11165	COG5016	pyruvate
HPY07_11170	COG3630	sodium ion export across plasma membrane
HPY07_11215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY07_11220	COG0527	aspartate kinase activity
HPY07_11225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY07_11235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY07_11245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY07_11250	COG4208	sulfate ABC transporter
HPY07_11270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY07_11275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY07_11285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY07_11290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY07_11295	COG0585	pseudouridine synthase activity
HPY07_11300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY07_11305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY07_11310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY07_11315	COG1968	undecaprenyl-diphosphatase activity
HPY07_11320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY07_11325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY07_11330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY07_11340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY07_11345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY07_11350	COG1610	YqeY-like protein
HPY07_11355	COG0358	DNA primase activity
HPY07_11375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY07_11380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY07_11385	COG1349	DNA-binding transcription factor activity
HPY07_11405	COG1279	arginine transmembrane transporter activity
HPY07_11410	COG0668	transmembrane transport
HPY07_11415	COG0191	fructose-bisphosphate aldolase activity
HPY07_11420	COG0126	phosphoglycerate kinase activity
HPY07_11425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY07_11430	COG4771	TonB-dependent receptor
HPY07_11435	COG0583	DNA-binding transcription factor activity
HPY07_11440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY07_11445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY07_11450	COG3091	SprT-like family
HPY07_11455	COG2356	endonuclease I
HPY07_11460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY07_11465	COG0189	ligase activity
HPY07_11470	COG1678	Uncharacterized ACR, COG1678
HPY07_11475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY07_11480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY07_11500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY07_11505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY07_11510	COG0762	integral membrane protein
HPY07_11515	COG1872	DUF167
HPY07_11525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY07_11530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY07_11535	COG2066	Belongs to the glutaminase family
HPY07_11540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY07_11545	COG1194	a g-specific adenine glycosylase
HPY07_11550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY07_11555	COG0741	lytic transglycosylase activity
HPY07_11580	COG0840	transmembrane signaling receptor activity
HPY07_11610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY07_11615	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY07_11620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY07_11625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY07_11630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY07_11635	COG2967	ApaG domain
HPY07_11640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY07_11650	COG3610	response to peptide
HPY07_11655	COG2966	Psort location CytoplasmicMembrane, score
HPY07_11660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY07_11665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY07_11670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY07_11675	COG0142	geranyltranstransferase activity
HPY07_11680	COG0531	amino acid
HPY07_11685	COG0039	L-malate dehydrogenase activity
HPY07_11690	COG1438	arginine binding
HPY07_11695	COG2358	TRAP transporter, solute receptor (TAXI family
HPY07_11705	COG0589	response to stress
HPY07_11725	COG2235	arginine
HPY07_11730	COG0312	modulator of DNA gyrase
HPY07_11735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY07_11740	COG3164	Protein of unknown function
HPY07_11745	COG1530	ribonuclease E activity
HPY07_11750	COG0424	maF-like protein
HPY07_11755	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY07_11760	COG1792	Involved in formation and maintenance of cell shape
HPY07_11765	COG1077	Cell shape determining protein MreB Mrl
HPY07_11810	COG1459	type II secretion system
HPY07_11815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY07_11825	COG3267	Type II secretory pathway component ExeA
HPY07_11825	COG3409	Peptidoglycan-binding domain 1 protein
HPY07_11850	COG2200	EAL domain
HPY07_11850	COG2199	diguanylate cyclase activity
HPY07_11855	COG0629	single-stranded DNA binding
HPY07_11870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY07_11885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY07_11890	COG0527	aspartate kinase activity
HPY07_11895	COG1410	methionine synthase
HPY07_11895	COG0646	methionine synthase
HPY07_11965	COG0175	sulfate reduction
HPY07_11975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY07_12000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY07_12005	COG0735	belongs to the Fur family
HPY07_12020	COG0166	Belongs to the GPI family
HPY07_12025	COG0432	Pfam Uncharacterised protein family UPF0047
HPY07_12030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY07_12045	COG0359	binds to the 23S rRNA
HPY07_12050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY07_12055	COG2965	DNA replication, synthesis of RNA primer
HPY07_12060	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY07_12070	COG2906	2 iron, 2 sulfur cluster binding
HPY07_12075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY07_12080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY07_12085	COG0049	tRNA binding
HPY07_12100	COG2923	Belongs to the DsrF TusC family
HPY07_12105	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY07_12110	COG2964	Protein conserved in bacteria
HPY07_12115	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY07_12125	COG2900	Belongs to the SlyX family
HPY07_12130	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY07_12135	COG0330	HflC and HflK could
HPY07_12140	COG0330	HflC and HflK could
HPY07_12145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY07_12150	COG1923	regulation of RNA biosynthetic process
HPY07_12155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY07_12160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY07_12170	COG0802	atpase or kinase
HPY07_12175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY07_12225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY07_12230	COG1162	GTPase activity
HPY07_12235	COG0688	phosphatidylethanolamine metabolic process
HPY07_12240	COG0471	metal ion transport
HPY07_12250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY07_12255	COG4942	peptidase
HPY07_12270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY07_12275	COG2816	NAD+ diphosphatase activity
HPY07_12280	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY07_12285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY07_12290	COG0085	RNA polymerase activity
HPY07_12295	COG0222	ribosome binding
HPY07_12300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY07_12310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY07_12315	COG0250	Participates in transcription elongation, termination and antitermination
HPY07_12320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY07_12325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY07_12350	COG1072	(Pantothenic acid kinase))
HPY07_12360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY07_12370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY07_12415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY07_12430	COG3118	belongs to the thioredoxin family
HPY07_12435	COG0513	Belongs to the DEAD box helicase family
HPY07_12440	COG0248	Ppx GppA phosphatase
HPY07_12445	COG2205	protein histidine kinase activity
HPY07_12445	COG0784	Response regulator, receiver
HPY07_12450	COG2814	Major facilitator Superfamily
HPY07_12465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY07_12470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY07_12475	COG0511	ligase activity, forming carbon-carbon bonds
HPY07_12480	COG0439	Biotin carboxylase
HPY07_12485	COG2264	protein methyltransferase activity
HPY07_12490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY07_12495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY07_12500	COG1609	Transcriptional regulator
HPY07_12510	COG0387	Pfam Sodium calcium exchanger
HPY07_12515	COG0129	dihydroxy-acid dehydratase activity
HPY07_12520	COG3265	gluconokinase activity
HPY07_12530	COG0800	Aldolase
HPY07_12550	COG0840	transmembrane signaling receptor activity
HPY07_12555	COG1982	Orn Lys Arg decarboxylase major
HPY07_12560	COG0531	amino acid
HPY07_12565	COG2203	Gaf domain
HPY07_12565	COG2199	diguanylate cyclase activity
HPY07_12570	COG3710	Transcriptional regulator
HPY07_12575	COG0789	Transcriptional regulator
HPY07_12590	COG0151	Belongs to the GarS family
HPY07_12600	COG0776	regulation of translation
HPY07_12605	COG1253	flavin adenine dinucleotide binding
HPY07_12610	COG3068	Protein conserved in bacteria
HPY07_12620	COG1573	uracil-dna glycosylase
HPY07_12625	COG0668	transmembrane transport
HPY07_12630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY07_12640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY07_12645	COG1216	Glycosyl transferase, family 2
HPY07_12670	COG1028	Short-chain dehydrogenase reductase Sdr
HPY07_12675	COG1083	cytidylyl-transferase
HPY07_12685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY07_12685	COG0517	IMP dehydrogenase activity
HPY07_12695	COG2089	acid synthase
HPY07_12700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY07_12705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY07_12725	COG1596	polysaccharide export
HPY07_12745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY07_12760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY07_12795	COG0463	Glycosyl transferase, family 2
HPY07_12810	COG4106	trans-aconitate 2-methyltransferase activity
HPY07_12845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY07_12865	COG0859	PFAM glycosyl transferase family 9
HPY07_12875	COG1519	Transferase
HPY07_12880	COG0456	acetyltransferase
HPY07_12885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY07_12900	COG3642	lipopolysaccharide core region biosynthetic process
HPY07_12905	COG0859	PFAM glycosyl transferase family 9
HPY07_12910	COG0463	Glycosyl transferase, family 2
HPY07_12915	COG0859	PFAM glycosyl transferase family 9
HPY07_12920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY07_12925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY07_12935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY07_12940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY07_12945	COG2003	Belongs to the UPF0758 family
HPY07_12950	COG0840	transmembrane signaling receptor activity
HPY07_12955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY07_12965	COG1309	transcriptional regulator
HPY07_12970	COG1560	Kdo2-lipid A biosynthetic process
HPY07_12975	COG1560	Kdo2-lipid A biosynthetic process
HPY07_12980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY07_12985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY07_12990	COG1561	YicC-like family, N-terminal region
HPY07_12995	COG2862	Uncharacterized protein family, UPF0114
HPY07_13000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY07_13005	COG1263	PTS System
HPY07_13005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY07_13010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY07_13025	COG0514	ATP-dependent DNA helicase (RecQ)
HPY07_13030	COG2962	Rard protein
HPY07_13035	COG0405	Gamma-glutamyltransferase
HPY07_13045	COG1280	lysine exporter protein (LysE YggA)
HPY07_13050	COG0210	DNA helicase
HPY07_13060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY07_13065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY07_13075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY07_13085	COG0747	negative chemotaxis
HPY07_13135	COG1309	transcriptional regulator
HPY07_13140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY07_13145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY07_13150	COG2960	long-chain fatty acid transporting porin activity
HPY07_13155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY07_13160	COG0583	DNA-binding transcription factor activity
HPY07_13230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY07_13235	COG1739	Uncharacterized protein family UPF0029
HPY07_13240	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY07_13240	COG1024	Enoyl-CoA hydratase
HPY07_13245	COG0183	Belongs to the thiolase family
HPY07_13250	COG0583	DNA-binding transcription factor activity
HPY07_13255	COG2814	Major facilitator Superfamily
HPY07_13265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY07_13270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY07_13275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY07_13280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY07_13285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY07_13290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY07_13300	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY07_13305	COG3312	ion transport
HPY07_13310	COG1475	DNA binding
HPY07_13315	COG1192	Involved in chromosome partitioning
HPY07_13320	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY07_13325	COG0445	tRNA wobble uridine modification
HPY07_13330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY07_13335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY07_13350	COG0594	ribonuclease P activity
HPY07_13355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY07_13360	COG1126	abc transporter atp-binding protein
HPY07_13405	COG0217	transcriptional regulatory protein
HPY07_13410	COG2084	Dehydrogenase
HPY07_13425	COG2909	trisaccharide binding
HPY07_13430	COG0058	SHG alpha-glucan phosphorylase activity
HPY07_13435	COG1640	4-alpha-glucanotransferase
HPY07_13440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY07_13450	COG3501	Rhs element vgr protein
HPY07_13485	COG0471	metal ion transport
HPY07_13490	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY07_13520	COG0671	phosphoesterase, PA-phosphatase related
HPY07_13530	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY07_13540	COG1999	signal sequence binding
HPY07_13555	COG0786	glutamate:sodium symporter activity
HPY07_13575	COG1566	PFAM secretion protein HlyD family protein
HPY07_13585	COG3706	GGDEF domain
HPY07_13600	COG0813	purine-nucleoside phosphorylase activity
HPY07_13605	COG3272	Protein of unknown function (DUF1722)
HPY07_13615	COG0415	Belongs to the DNA photolyase family
HPY07_13620	COG1388	LysM domain
HPY07_13620	COG1376	ErfK ybiS ycfS ynhG family protein
HPY07_13630	COG0513	Belongs to the DEAD box helicase family
HPY07_13635	COG1770	oligopeptidase
HPY07_13665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY07_13670	COG0573	inorganic phosphate transmembrane transporter activity
HPY07_13675	COG0581	inorganic phosphate transmembrane transporter activity
HPY07_13680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY07_13705	COG0659	secondary active sulfate transmembrane transporter activity
HPY07_13715	COG0739	heme binding
HPY07_13720	COG5001	Diguanylate cyclase
HPY07_13720	COG3300	MHYT domain
HPY07_13725	COG0583	DNA-binding transcription factor activity
HPY07_13730	COG2814	Major facilitator Superfamily
HPY07_13750	COG1301	dicarboxylic acid transport
HPY07_13765	COG1342	Belongs to the UPF0251 family
HPY07_13800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY07_13815	COG2771	luxR family
HPY07_13815	COG2200	EAL domain
HPY07_13820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY07_13830	COG0564	pseudouridine synthase activity
HPY07_13935	COG1869	D-ribose catabolic process
HPY07_13940	COG1129	ABC transporter
HPY07_13945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY07_13950	COG1879	ABC-type sugar transport system periplasmic component
HPY07_13955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY07_13960	COG1609	Transcriptional regulator
HPY07_13970	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY07_13980	COG0584	glycerophosphoryl diester phosphodiesterase
HPY07_13985	COG2271	Major facilitator Superfamily
HPY07_14020	COG0579	oxidoreductase
HPY07_14030	COG0242	peptide deformylase activity
HPY07_14035	COG1017	nitric oxide dioxygenase activity
HPY07_14035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY07_14040	COG1320	monovalent cation:proton antiporter activity
HPY07_14045	COG2212	antiporter activity
HPY07_14065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY07_14065	COG2111	Na H antiporter
HPY07_14075	COG0589	response to stress
HPY07_14080	COG0814	amino acid
HPY07_14095	COG3530	Putative quorum-sensing-regulated virulence factor
HPY07_14105	COG5002	protein histidine kinase activity
HPY07_14105	COG5001	Diguanylate cyclase
HPY07_14110	COG1278	Cold shock
HPY07_14125	COG2304	oxidoreductase activity
HPY07_14145	COG0714	Associated with various cellular activities
HPY07_14150	COG0840	transmembrane signaling receptor activity
HPY07_14165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY07_14170	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY07_14180	COG3604	Transcriptional regulator
HPY07_14185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY07_14185	COG1017	nitric oxide dioxygenase activity
HPY07_14190	COG1278	Cold shock
HPY07_14195	COG3036	rescue of stalled ribosome
HPY07_14220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY07_14220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY07_14225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY07_14235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY07_14245	COG0516	GMP reductase activity
HPY07_14250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY07_14255	COG0513	Belongs to the DEAD box helicase family
HPY07_14260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY07_14265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY07_14270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY07_14275	COG3437	response regulator, receiver
HPY07_14275	COG0784	Response regulator, receiver
HPY07_14285	COG4191	Histidine kinase
HPY07_14285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY07_14295	COG1757	Na H antiporter
HPY07_14300	COG2814	Major facilitator Superfamily
HPY07_14310	COG3240	lipase activity
HPY07_14320	COG0840	transmembrane signaling receptor activity
HPY07_14325	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY07_14330	COG5380	lipid catabolic process
HPY07_14360	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY07_14365	COG4605	iron ion homeostasis
HPY07_14370	COG4604	ABC transporter, ATP-binding protein
HPY07_14375	COG2207	Transcriptional regulator
HPY07_14390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY07_14395	COG0640	Transcriptional regulator
HPY07_14400	COG0798	PFAM Bile acid sodium symporter
HPY07_14415	COG0583	DNA-binding transcription factor activity
HPY07_14430	COG0745	RESPONSE REGULATOR receiver
HPY07_14440	COG3623	hexulose-6-phosphate isomerase
HPY07_14445	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY07_14450	COG0561	phosphatase activity
HPY07_14495	COG1335	isochorismatase
HPY07_14500	COG1741	Belongs to the pirin family
HPY07_14505	COG0583	DNA-binding transcription factor activity
HPY07_14510	COG0366	Alpha amylase catalytic
HPY07_14530	COG0745	RESPONSE REGULATOR receiver
HPY07_14535	COG5002	protein histidine kinase activity
HPY07_14560	COG0583	DNA-binding transcription factor activity
HPY07_14575	COG1686	Belongs to the peptidase S11 family
HPY07_14595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY07_14595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY07_14600	COG0509	glycine decarboxylation via glycine cleavage system
HPY07_14605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY07_14615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY07_14630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY07_14635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY07_14665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_14785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY07_14870	COG0384	phenazine biosynthesis protein PhzF
HPY07_14885	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY07_14895	COG0653	protein targeting
HPY07_15010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_15080	COG0456	acetyltransferase
HPY07_15390	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY07_15400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY07_15405	COG1605	Chorismate mutase
HPY07_15475	COG2801	Transposase and inactivated derivatives
HPY07_15515	COG2801	Transposase and inactivated derivatives
HPY07_15555	COG0456	acetyltransferase
HPY07_15600	COG3041	Addiction module toxin RelE StbE family
HPY07_15620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_15645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY07_15735	COG0384	phenazine biosynthesis protein PhzF
HPY07_15770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_15830	COG1418	mRNA catabolic process
HPY07_15905	COG2801	Transposase and inactivated derivatives
HPY07_15990	COG0384	phenazine biosynthesis protein PhzF
HPY07_16060	COG1492	cobalamin metabolic process
HPY07_16065	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY07_16070	COG4149	molybdate abc transporter
HPY07_16075	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY07_16105	COG1289	transmembrane transporter activity
HPY07_16110	COG0210	DNA helicase
HPY07_16115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY07_16120	COG1335	isochorismatase
HPY07_16125	COG1803	Methylglyoxal synthase
HPY07_16130	COG1879	ABC-type sugar transport system periplasmic component
HPY07_16135	COG0784	Response regulator, receiver
HPY07_16135	COG2205	protein histidine kinase activity
HPY07_16135	COG2198	Histidine kinase
HPY07_16140	COG0469	pyruvate kinase activity
HPY07_16145	COG2271	Major facilitator Superfamily
HPY07_16155	COG4191	Histidine kinase
HPY07_16170	COG1979	alcohol dehydrogenase
HPY07_16180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY07_16185	COG3706	GGDEF domain
HPY07_16200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY07_16205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY07_16215	COG0183	Belongs to the thiolase family
HPY07_16225	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY07_16230	COG3842	ATPase activity
HPY07_16240	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY07_16245	COG2271	Major facilitator Superfamily
HPY07_16250	COG3851	Histidine kinase
HPY07_16255	COG2197	response regulator
HPY07_16260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY07_16280	COG0243	molybdopterin cofactor binding
HPY07_16290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY07_16295	COG3850	Histidine kinase
HPY07_16300	COG2197	response regulator
HPY07_16305	COG1760	l-serine dehydratase
HPY07_16310	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY07_16315	COG0840	transmembrane signaling receptor activity
HPY07_16320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY07_16330	COG1328	CTP reductase activity
HPY07_16335	COG0602	queuosine metabolic process
HPY07_16345	COG0189	ligase activity
HPY07_16345	COG4067	protein conserved in archaea
HPY07_16350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY07_16350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY07_16350	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY07_16355	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY07_16360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY07_16360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY07_16365	COG1609	Transcriptional regulator
HPY07_16370	COG0420	3'-5' exonuclease activity
HPY07_16375	COG0419	ATPase involved in DNA repair
HPY07_16380	COG0784	Response regulator, receiver
HPY07_16380	COG2205	protein histidine kinase activity
HPY07_16385	COG0156	8-amino-7-oxononanoate synthase activity
HPY07_16395	COG0038	chloride channel
HPY07_16400	COG0523	cobalamin synthesis protein
HPY07_16410	COG3158	transport of potassium into the cell
HPY07_16415	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY07_16415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY07_16415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY07_16415	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY07_16420	COG2205	protein histidine kinase activity
HPY07_16425	COG0745	RESPONSE REGULATOR receiver
HPY07_16430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY07_16445	COG2200	EAL domain
HPY07_16455	COG3038	cytochrome b561
HPY07_16465	COG2116	formate transmembrane transporter activity
HPY07_16470	COG0583	DNA-binding transcription factor activity
HPY07_16480	COG3593	DNA synthesis involved in DNA repair
HPY07_16485	COG0737	Belongs to the 5'-nucleotidase family
HPY07_16500	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY07_16550	COG3706	GGDEF domain
HPY07_16565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY07_16570	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY07_16580	COG4771	TonB-dependent receptor
HPY07_16580	COG1629	transport
HPY07_16585	COG0583	DNA-binding transcription factor activity
HPY07_16590	COG1042	CoA-binding domain protein
HPY07_16590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_16590	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY07_16610	COG0023	Translation Initiation Factor
HPY07_16615	COG3140	Belongs to the UPF0181 family
HPY07_16630	COG0745	RESPONSE REGULATOR receiver
HPY07_16655	COG2050	protein possibly involved in aromatic compounds catabolism
HPY07_16675	COG0625	glutathione transferase activity
HPY07_16690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY07_16695	COG4172	Belongs to the ABC transporter superfamily
HPY07_16700	COG4239	(ABC) transporter, permease
HPY07_16705	COG4174	ABC transporter (Permease)
HPY07_16710	COG4166	transmembrane transport
HPY07_16755	COG3842	ATPase activity
HPY07_16760	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY07_16775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY07_16780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY07_16785	COG1011	Hydrolase
HPY07_16800	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY07_16805	COG1970	mechanosensitive ion channel activity
HPY07_16810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY07_16815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY07_16815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY07_16820	COG0302	gtp cyclohydrolase
HPY07_16830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY07_16840	COG2897	thiosulfate sulfurtransferase activity
HPY07_16845	COG2390	Transcriptional regulator
HPY07_16855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY07_16880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY07_16905	COG0583	DNA-binding transcription factor activity
HPY07_16910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY07_16950	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY07_16995	COG1263	PTS System
HPY07_16995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY07_17005	COG1621	beta-fructofuranosidase activity
HPY07_17010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY07_17015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY07_17020	COG0840	transmembrane signaling receptor activity
HPY07_17030	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY07_17070	COG2801	Transposase and inactivated derivatives
HPY07_17130	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY07_17170	COG0456	acetyltransferase
HPY07_17230	COG4977	sequence-specific DNA binding
HPY07_17230	COG1917	Cupin 2, conserved barrel domain protein
HPY07_17235	COG4771	TonB-dependent receptor
HPY07_17240	COG2814	Major facilitator Superfamily
HPY07_17245	COG3433	isochorismatase activity
HPY07_17245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY07_17245	COG2226	methyltransferase
HPY07_17270	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY07_17275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY07_17295	COG1132	(ABC) transporter
HPY07_17300	COG1132	(ABC) transporter
HPY07_17310	COG0784	Response regulator, receiver
HPY07_17310	COG5002	protein histidine kinase activity
HPY07_17315	COG1879	ABC-type sugar transport system periplasmic component
HPY07_17325	COG2827	Endonuclease containing a URI domain
HPY07_17330	COG3132	Protein of unknown function, DUF480
HPY07_17340	COG2926	Belongs to the UPF0265 family
HPY07_17355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY07_17360	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY07_17370	COG0247	lactate metabolic process
HPY07_17375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY07_17380	COG3118	belongs to the thioredoxin family
HPY07_17405	COG4160	amino acid transport
HPY07_17410	COG4215	(ABC) transporter
HPY07_17415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY07_17420	COG1126	abc transporter atp-binding protein
HPY07_17430	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY07_17440	COG0494	nUDIX hydrolase
HPY07_17445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY07_17455	COG1309	transcriptional regulator
HPY07_17460	COG0513	Belongs to the DEAD box helicase family
HPY07_17465	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY07_17470	COG0814	amino acid
HPY07_17475	COG0840	transmembrane signaling receptor activity
HPY07_17480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY07_17485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY07_17495	COG1984	allophanate hydrolase subunit 2
HPY07_17510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY07_17515	COG4181	ATPase activity
HPY07_17525	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY07_17530	COG5001	Diguanylate cyclase
HPY07_17530	COG1716	ATPase activity
HPY07_17540	COG0484	heat shock protein binding
HPY07_17555	COG0546	phosphoglycolate phosphatase activity
HPY07_17570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY07_17580	COG0513	Belongs to the DEAD box helicase family
HPY07_17595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY07_17605	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY07_17610	COG3397	chitin binding
HPY07_17615	COG3227	Zinc metalloprotease (Elastase)
HPY07_17630	COG1166	arginine decarboxylase activity
HPY07_17640	COG2239	Acts as a magnesium transporter
HPY07_17650	COG0527	aspartate kinase activity
HPY07_17655	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY07_17660	COG3186	Phenylalanine-4-hydroxylase
HPY07_17665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY07_17680	COG2264	protein methyltransferase activity
HPY07_17705	COG1253	flavin adenine dinucleotide binding
HPY07_17710	COG1765	OsmC-like protein
HPY07_17740	COG1252	NADH dehydrogenase
HPY07_17745	COG0531	amino acid
HPY07_17750	COG3706	GGDEF domain
HPY07_17760	COG3279	Response regulator of the LytR AlgR family
HPY07_17765	COG3275	phosphorelay sensor kinase activity
HPY07_17780	COG0577	efflux transmembrane transporter activity
HPY07_17780	COG1136	(ABC) transporter
HPY07_17785	COG1136	(ABC) transporter
HPY07_17795	COG4989	oxidoreductase activity
HPY07_17800	COG0366	Alpha amylase catalytic
HPY07_17810	COG2067	long-chain fatty acid transport protein
HPY07_17815	COG2267	carboxylic ester hydrolase activity
HPY07_17825	COG3227	Zinc metalloprotease (Elastase)
HPY07_17830	COG3047	cAMP biosynthetic process
HPY07_17840	COG1686	Belongs to the peptidase S11 family
HPY07_17845	COG0557	exoribonuclease II activity
HPY07_17850	COG1278	Cold shock
HPY07_17860	COG3048	D-serine ammonia-lyase activity
HPY07_17865	COG0583	DNA-binding transcription factor activity
HPY07_17885	COG2801	Transposase and inactivated derivatives
HPY07_17890	COG5002	protein histidine kinase activity
HPY07_17915	COG0582	viral genome integration into host DNA
HPY07_17935	COG1063	alcohol dehydrogenase
HPY07_17960	COG1278	Cold shock
HPY07_17965	COG0557	exoribonuclease II activity
HPY07_18085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY07_18090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY07_18095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY07_18115	COG1278	Cold shock
HPY07_18140	COG1802	Transcriptional regulator
HPY07_18140	COG4626	Terminase
HPY07_18170	COG0582	viral genome integration into host DNA
HPY07_18185	COG1063	alcohol dehydrogenase
HPY07_18190	COG0156	8-amino-7-oxononanoate synthase activity
HPY07_18210	COG0346	lactoylglutathione lyase activity
HPY07_18230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY07_18235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY07_18240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY07_18245	COG0363	glucosamine-6-phosphate deaminase activity
HPY07_18250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY07_18275	COG1929	Belongs to the glycerate kinase type-1 family
HPY07_18280	COG2610	gluconate transmembrane transporter activity
HPY07_18285	COG3835	regulator
HPY07_18295	COG0748	coenzyme F420 binding
HPY07_18300	COG3721	Heme iron utilization protein
HPY07_18310	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY07_18315	COG0811	peptide transport
HPY07_18320	COG0848	biopolymer transport protein
HPY07_18325	COG4558	Periplasmic binding protein
HPY07_18330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY07_18335	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY07_18370	COG0633	Ferredoxin
HPY07_18370	COG3217	Mosc domain protein beta barrel domain protein
HPY07_18370	COG0633	Ferredoxin
HPY07_18370	COG3217	Mosc domain protein beta barrel domain protein
HPY07_18375	COG0418	dihydroorotase activity
HPY07_18380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY07_18385	COG2354	Protein conserved in bacteria
HPY07_18395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY07_18400	COG1278	Cold shock
HPY07_18425	COG3706	GGDEF domain
HPY07_18430	COG1349	DNA-binding transcription factor activity
HPY07_18445	COG3833	ABC-type maltose transport systems, permease component
HPY07_18450	COG1175	transmembrane transport
HPY07_18460	COG3842	ATPase activity
HPY07_18465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY07_18480	COG0393	Putative heavy-metal-binding
HPY07_18490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY07_18495	COG0835	chemotaxis
HPY07_18495	COG0784	Response regulator, receiver
HPY07_18500	COG1846	Transcriptional regulator
HPY07_18505	COG3706	GGDEF domain
HPY07_18540	COG0583	DNA-binding transcription factor activity
HPY07_18545	COG5001	Diguanylate cyclase
HPY07_18555	COG1741	Belongs to the pirin family
HPY07_18560	COG3123	guanosine phosphorylase activity
HPY07_18570	COG2211	Major facilitator Superfamily
HPY07_18580	COG1067	ATP-dependent peptidase activity
HPY07_18590	COG4172	Belongs to the ABC transporter superfamily
HPY07_18610	COG0583	DNA-binding transcription factor activity
HPY07_18620	COG1620	l-lactate permease
HPY07_18635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY07_18645	COG0840	transmembrane signaling receptor activity
HPY07_18665	COG2258	MOSC domain
HPY07_18670	COG0513	Belongs to the DEAD box helicase family
HPY07_18680	COG2186	Transcriptional regulator
HPY07_18690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY07_18700	COG0246	Mannitol dehydrogenase
HPY07_18705	COG1904	glucuronate isomerase
HPY07_18710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY07_18715	COG0800	Aldolase
HPY07_18725	COG0583	DNA-binding transcription factor activity
HPY07_18735	COG1902	pentaerythritol trinitrate reductase activity
HPY07_18745	COG1132	(ABC) transporter
HPY07_18755	COG1902	pentaerythritol trinitrate reductase activity
HPY07_18765	COG1280	lysine exporter protein (LysE YggA)
HPY07_18770	COG2207	Transcriptional regulator
HPY07_18790	COG1846	Transcriptional regulator
HPY07_18795	COG1764	response to oxidative stress
HPY07_18800	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY07_18805	COG0697	spore germination
HPY07_18815	COG0700	Nucleoside recognition
HPY07_18820	COG3366	ferrous iron transmembrane transporter activity
HPY07_18825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY07_18835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY07_18840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY07_18845	COG2259	Doxx family
HPY07_18870	COG0363	glucosamine-6-phosphate deaminase activity
HPY07_18885	COG4580	involved in the transport of maltose and maltodextrins
HPY07_18900	COG0840	transmembrane signaling receptor activity
HPY07_18910	COG0840	transmembrane signaling receptor activity
HPY07_18920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY07_18925	COG1126	abc transporter atp-binding protein
HPY07_18935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY07_18940	COG4597	amino acid ABC transporter
HPY07_18945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY07_18950	COG2213	PTS system mannitol-specific
HPY07_18950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY07_18955	COG0246	Mannitol dehydrogenase
HPY07_18960	COG3722	fumarate hydratase activity
HPY07_18965	COG0673	inositol 2-dehydrogenase activity
HPY07_18995	COG2910	NAD(P)H-binding
HPY07_19005	COG0840	transmembrane signaling receptor activity
HPY07_19010	COG4221	oxidoreductase activity
HPY07_19015	COG0583	DNA-binding transcription factor activity
HPY07_19020	COG1901	pseudouridine methyltransferase
HPY07_19035	COG0531	amino acid
HPY07_19040	COG1982	Orn Lys Arg decarboxylase major
HPY07_19050	COG2197	response regulator
HPY07_19090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY07_19115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY07_19180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY07_19185	COG0840	transmembrane signaling receptor activity
HPY07_19190	COG0835	chemotaxis
HPY07_19195	COG0835	chemotaxis
HPY07_19200	COG2198	Histidine kinase
HPY07_19200	COG0643	Histidine kinase
HPY07_19220	COG0601	transmembrane transport
HPY07_19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY07_19235	COG2194	sulfuric ester hydrolase activity
HPY07_19240	COG0642	Histidine kinase
HPY07_19245	COG0745	RESPONSE REGULATOR receiver
HPY07_19275	COG1444	tRNA N-acetyltransferase activity
HPY07_19280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine