locus-tag	class	description
HPY08_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPY08_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY08_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPY08_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY08_00030	ENOG4108ZNX	Heat shock protein
HPY08_00035	ENOG4105JKW	Valine--pyruvate aminotransferase
HPY08_00040	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HPY08_00045	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HPY08_00060	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HPY08_00070	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HPY08_00075	ENOG4105C7B	Threonine dehydratase
HPY08_00080	ENOG4105C01	Dihydroxy-acid dehydratase
HPY08_00085	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPY08_00100	ENOG4105C0P	Mg chelatase subunit ChlI
HPY08_00105	ENOG4106HNH	Acyl-transferase
HPY08_00110	ENOG4108Z33	Thiol disulfide Interchange Protein
HPY08_00115	ENOG4105E27	serine threonine protein kinase
HPY08_00125	ENOG4105PC1	Conserved Protein
HPY08_00130	ENOG4108N23	SpoOM-related protein
HPY08_00135	ENOG4108UT2	hemolysin iii
HPY08_00145	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY08_00150	ENOG4105C1A	potassium transporter peripheral membrane
HPY08_00155	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HPY08_00160	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HPY08_00170	ENOG4108WZM	domain protein
HPY08_00175	ENOG4105C79	DNA protecting protein DprA
HPY08_00180	ENOG4108RPN	Protein smg homolog
HPY08_00185	ENOG4108WI1	Dna topoisomerase
HPY08_00190	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HPY08_00195	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HPY08_00200	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY08_00205	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HPY08_00210	ENOG4105E2X	shikimate dehydrogenase
HPY08_00220	ENOG4108Z0R	Transferase
HPY08_00255	ENOG4105WMR	Protein CrcB homolog
HPY08_00260	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HPY08_00270	ENOG4105D06	uba thif-type nad fad binding protein
HPY08_00275	ENOG4105WHD	thiamine biosynthesis protein ThiS
HPY08_00280	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPY08_00285	ENOG4105D41	biosynthesis protein thiH
HPY08_00290	ENOG4105DC7	peptidase M24
HPY08_00290	ENOG4105DC7	peptidase M24
HPY08_00295	ENOG4105G2Y	Transcriptional regulator
HPY08_00300	ENOG4105CNH	Multidrug resistance protein MdtL
HPY08_00310	ENOG4108VVK	transcriptional Regulator, AsnC
HPY08_00315	ENOG4105BZU	Histidine kinase
HPY08_00330	ENOG4105EMK	carboxylate amino acid amine transporter
HPY08_00335	ENOG4108M6U	Universal stress protein A
HPY08_00340	ENOG41090A1	ferritin
HPY08_00345	ENOG4108V6B	universal stress protein B
HPY08_00350	ENOG4105CBX	hi0933 family
HPY08_00360	ENOG4105CGY	Dna recombination protein
HPY08_00365	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPY08_00370	ENOG4105JC1	sterol-binding domain protein
HPY08_00380	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY08_00385	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPY08_00390	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPY08_00395	ENOG4107R73	Mate efflux family protein
HPY08_00405	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPY08_00410	ENOG4105E55	glycerol-3-phosphate acyltransferase
HPY08_00415	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HPY08_00420	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HPY08_00425	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY08_00430	ENOG4107SDU	Methyl-accepting chemotaxis
HPY08_00440	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HPY08_00450	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPY08_00460	ENOG4105C2M	dna polymerase I
HPY08_00470	ENOG4106RE7	Cytochrome
HPY08_00480	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HPY08_00485	ENOG4105XCT	Protein of unknown function (DUF2489)
HPY08_00490	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY08_00495	ENOG410601J	HemY protein
HPY08_00500	ENOG4105ECF	c-methyltransferase
HPY08_00505	ENOG41076E6	Uroporphyrinogen-III Synthase
HPY08_00510	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPY08_00515	ENOG4107T0K	Adenylate cyclase
HPY08_00520	ENOG4105XQ6	frataxin-like protein
HPY08_00530	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPY08_00535	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPY08_00540	ENOG4105CT0	Protein of unknown function, DUF484
HPY08_00545	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY08_00550	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HPY08_00555	ENOG4105BZU	Histidine kinase
HPY08_00570	ENOG4105DQF	Hydrolase
HPY08_00575	ENOG4108EUD	Lysophospholipase
HPY08_00580	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY08_00585	ENOG4105D58	Diguanylate phosphodiesterase
HPY08_00590	ENOG4108RMU	ferritin dps family protein
HPY08_00620	ENOG4106H78	methyltransferase
HPY08_00625	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPY08_00630	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPY08_00635	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HPY08_00640	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY08_00645	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HPY08_00660	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HPY08_00665	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY08_00670	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HPY08_00675	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPY08_00740	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPY08_00745	ENOG4105BZU	Histidine kinase
HPY08_00750	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_00755	ENOG4105CUX	Signal transduction histidine kinase
HPY08_00765	ENOG4105C5F	glutamine synthetase
HPY08_00775	ENOG4105CI3	gtp-binding protein typa
HPY08_00785	ENOG4107S2Z	UPF0761 membrane protein
HPY08_00790	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPY08_00795	ENOG4105SUU	thioesterase domain
HPY08_00805	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HPY08_00810	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HPY08_00815	ENOG4105VEJ	Heat shock protein
HPY08_00820	ENOG4108XKW	General secretion pathway protein C
HPY08_00830	ENOG4107QHF	type ii secretion system protein e
HPY08_00835	ENOG4105D7Q	type ii secretion system
HPY08_00840	ENOG4108VAU	general secretion pathway protein G
HPY08_00845	ENOG4105VWV	general secretion pathway protein h
HPY08_00850	ENOG4105X5Z	General secretion pathway protein I
HPY08_00855	ENOG4108WWZ	General secretion pathway protein J
HPY08_00860	ENOG4108RTD	type II secretion system protein K
HPY08_00865	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HPY08_00870	ENOG4105U1E	general secretion pathway protein M
HPY08_00875	ENOG4105PIC	general secretion pathway protein N
HPY08_00880	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HPY08_00885	ENOG4107RK2	ADP-ribose diphosphatase NudE
HPY08_00895	ENOG4105MJ2	Competence protein
HPY08_00905	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY08_00915	ENOG4105BZM	domain protein
HPY08_00920	ENOG4108RRZ	Transcription elongation factor GreB
HPY08_00925	ENOG4108KHX	Diguanylate cyclase
HPY08_00935	ENOG4105E0F	Histidine kinase
HPY08_00940	ENOG4105C2W	permease
HPY08_00945	ENOG4105CB5	ATP-dependent DNA helicase recG
HPY08_00950	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY08_00955	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HPY08_00960	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPY08_00965	ENOG4105EX9	Membrane
HPY08_00970	ENOG4107QN1	sodium solute
HPY08_00980	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HPY08_00990	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HPY08_01000	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY08_01005	ENOG4108IJ0	Aspartate ammonia-lyase
HPY08_01010	ENOG4105BZU	Histidine kinase
HPY08_01015	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HPY08_01020	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPY08_01030	ENOG4105E0F	Histidine kinase
HPY08_01035	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HPY08_01045	ENOG41076HS	cation diffusion facilitator family transporter
HPY08_01050	ENOG4105CTQ	phosphohexokinase
HPY08_01055	ENOG4105CBT	Fructose-1,6-bisphosphatase
HPY08_01065	ENOG4105SYT	Methylenetetrahydrofolate reductase
HPY08_01070	ENOG4105CFH	Aspartokinase
HPY08_01075	ENOG4105C28	cystathionine
HPY08_01080	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HPY08_01085	ENOG4105C6K	Malic enzyme
HPY08_01090	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPY08_01095	ENOG4105C25	Primosomal protein n'
HPY08_01100	ENOG4105ETE	Transcriptional regulator (LacI family
HPY08_01105	ENOG41063M6	Cell Division Protein
HPY08_01110	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HPY08_01115	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HPY08_01120	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HPY08_01125	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY08_01135	ENOG4105CP7	Triose-phosphate isomerase
HPY08_01160	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY08_01165	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY08_01175	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HPY08_01180	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY08_01190	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HPY08_01195	ENOG4105E33	succinate dehydrogenase
HPY08_01205	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HPY08_01210	ENOG4107YZP	Rhodanese domain protein
HPY08_01215	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HPY08_01220	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPY08_01225	ENOG4105D7W	serine acetyltransferase
HPY08_01235	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HPY08_01240	ENOG4105CWC	Acetylornithine deacetylase
HPY08_01245	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPY08_01250	ENOG4105CAS	nag kinase
HPY08_01255	ENOG4105CDH	Citrulline--aspartate ligase
HPY08_01260	ENOG4105CH7	arginosuccinase
HPY08_01270	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY08_01275	ENOG4105EHV	domain protein
HPY08_01285	ENOG4108RS6	transposase
HPY08_01295	ENOG4108RS6	transposase
HPY08_01300	ENOG4108JQC	penicillin-binding protein 1A
HPY08_01325	ENOG4105E4G	Type IV pilus
HPY08_01330	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPY08_01335	ENOG4105D49	3-dehydroquinate synthase
HPY08_01345	ENOG4105DFE	Dna adenine methylase
HPY08_01350	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPY08_01355	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY08_01360	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPY08_01375	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HPY08_01380	ENOG4105DDQ	anthranilate synthase
HPY08_01385	ENOG4105C8Y	Acetylornithine aminotransferase
HPY08_01395	ENOG4105C26	Dehydrogenase
HPY08_01405	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HPY08_01410	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HPY08_01420	ENOG4105DNZ	Alpha Beta Hydrolase
HPY08_01430	ENOG4105C5H	ABC transporter
HPY08_01435	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPY08_01450	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HPY08_01455	ENOG4105D44	asparaginase
HPY08_01460	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY08_01465	ENOG4108UV7	flagellar protein motX
HPY08_01470	ENOG4105E68	Sulfatase
HPY08_01475	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY08_01480	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPY08_01485	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPY08_01490	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPY08_01495	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPY08_01500	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPY08_01505	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY08_01510	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPY08_01515	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPY08_01520	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPY08_01525	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HPY08_01530	ENOG41083MP	50s ribosomal protein l29
HPY08_01535	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HPY08_01540	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPY08_01545	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPY08_01550	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY08_01555	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPY08_01560	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HPY08_01565	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HPY08_01570	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HPY08_01575	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPY08_01580	ENOG4105VPB	50S ribosomal protein L30
HPY08_01590	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HPY08_01600	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY08_01605	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPY08_01610	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPY08_01615	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY08_01620	ENOG4108ZT0	50S ribosomal protein l17
HPY08_01630	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY08_01635	ENOG4108UBT	opacity-associated protein
HPY08_01640	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY08_01645	ENOG4107YB6	acetyltransferase, (GNAT) family
HPY08_01650	ENOG4105C1J	atp-dependent rna helicase
HPY08_01660	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HPY08_01665	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPY08_01670	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HPY08_01675	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HPY08_01680	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HPY08_01700	ENOG4105C19	ABC transporter
HPY08_01715	ENOG4108UUE	Transcriptional regulator
HPY08_01720	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPY08_01725	ENOG4105CFU	surface antigen
HPY08_01735	ENOG41066HZ	AIG2-like family
HPY08_01740	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPY08_01750	ENOG4105DFU	Cell wall formation (By similarity)
HPY08_01755	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HPY08_01765	ENOG4106SMU	thiamine transporter membrane protein
HPY08_01770	ENOG4107T0D	ABC, transporter
HPY08_01775	ENOG4105N42	UPF0307 protein
HPY08_01780	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HPY08_01785	ENOG4105CJW	magnesium transporter
HPY08_01790	ENOG41080Z8	PHOSPHOCARRIER protein
HPY08_01795	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPY08_01800	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HPY08_01805	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HPY08_01810	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY08_01815	ENOG4108IUZ	ABC transporter
HPY08_01820	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HPY08_01830	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HPY08_01835	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY08_01845	ENOG4105DHJ	ABC, transporter
HPY08_01850	ENOG4105CY3	ABC transporter, permease
HPY08_01855	ENOG4107PE3	Mammalian cell entry related domain protein
HPY08_01860	ENOG4105E3I	toluene tolerance
HPY08_01870	ENOG4105VFK	BolA family
HPY08_01875	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPY08_01880	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HPY08_01885	ENOG4105KME	endoribonuclease L-psp
HPY08_01895	ENOG4105CXT	aspartate transcarbamylase
HPY08_01905	ENOG4108IAB	Phoh family
HPY08_01915	ENOG4105D3G	Pseudouridine synthase
HPY08_01920	ENOG4105C5I	Dehydrogenase
HPY08_01925	ENOG4108M3P	Membrane
HPY08_01935	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPY08_01940	ENOG4105MYG	DNA polymerase iii, chi subunit
HPY08_01945	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY08_01950	ENOG4108M8S	permease YjgP YjgQ family protein
HPY08_01955	ENOG4108K5H	permease YjgP YjgQ family protein
HPY08_01970	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY08_02010	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY08_02015	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY08_02020	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPY08_02040	ENOG41064T2	transcriptional regulator, lysR family
HPY08_02045	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY08_02050	ENOG4105C7K	acetolactate synthase
HPY08_02055	ENOG4108ZP8	Acetolactate synthase small subunit
HPY08_02060	ENOG4108JQ1	Dehydrogenase
HPY08_02065	ENOG4105E66	phosphoriboisomerase A
HPY08_02070	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HPY08_02080	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HPY08_02090	ENOG4105D0A	hydroxylase
HPY08_02095	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY08_02110	ENOG4105Y75	tpr repeat protein
HPY08_02120	ENOG4108IYU	L-aspartate oxidase
HPY08_02125	ENOG4105EMN	RNA polymerase sigma factor
HPY08_02130	ENOG41069PW	sigma-e factor negative regulatory protein
HPY08_02135	ENOG4105VQK	sigma E regulatory protein, MucB RseB
HPY08_02140	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
HPY08_02145	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPY08_02150	ENOG4105C3F	Signal peptidase i
HPY08_02155	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPY08_02160	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPY08_02165	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HPY08_02170	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HPY08_02195	ENOG4105BZU	Histidine kinase
HPY08_02205	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY08_02210	ENOG4105DXN	mazG family
HPY08_02215	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HPY08_02220	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPY08_02225	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HPY08_02240	ENOG4106MWK	domain protein
HPY08_02245	ENOG4105CJ3	phosphate transporter
HPY08_02250	ENOG4107IX6	phosphate transport regulator
HPY08_02255	ENOG4105I7R	Adenylate cyclase
HPY08_02260	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_02265	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPY08_02275	ENOG4105DFG	type I secretion outer membrane protein
HPY08_02280	ENOG41087AY	ADP-Ribose pyrophosphatase
HPY08_02285	ENOG4108SX3	cytoplasmic protein
HPY08_02290	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HPY08_02295	ENOG4105IPS	esterase
HPY08_02300	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY08_02305	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY08_02315	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HPY08_02320	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPY08_02325	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HPY08_02330	ENOG4105D7Q	type ii secretion system
HPY08_02335	ENOG4107QHF	type ii secretion system protein e
HPY08_02340	ENOG4108ZUW	Major pilin subunit
HPY08_02345	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HPY08_02355	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY08_02360	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY08_02365	ENOG4105T95	Thiol disulfide interChange protein
HPY08_02370	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HPY08_02375	ENOG41073TP	transcriptional regulator
HPY08_02380	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPY08_02385	ENOG4107QSN	dihydrolipoamide acetyltransferase
HPY08_02390	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY08_02405	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPY08_02410	ENOG4105CJN	penicillin-binding protein
HPY08_02415	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPY08_02420	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HPY08_02430	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPY08_02440	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HPY08_02445	ENOG4105DFU	Cell wall formation (By similarity)
HPY08_02450	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HPY08_02455	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HPY08_02460	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPY08_02465	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY08_02475	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY08_02480	ENOG4105M6F	mutator MutT protein
HPY08_02485	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPY08_02490	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HPY08_02495	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPY08_02510	ENOG4105EJ9	Membrane
HPY08_02515	ENOG4105VP0	transcriptional regulator, lysR family
HPY08_02520	ENOG4105EN6	Membrane
HPY08_02525	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HPY08_02535	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPY08_02545	ENOG4105BZ8	glutamate synthase
HPY08_02550	ENOG4105CBC	glutamate synthase
HPY08_02565	ENOG4105N5T	Radical SAM Protein
HPY08_02575	ENOG4105BZU	Histidine kinase
HPY08_02580	ENOG41065U4	response regulator
HPY08_02590	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY08_02610	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPY08_02615	ENOG4105D98	threonine synthase
HPY08_02620	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HPY08_02625	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HPY08_02630	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPY08_02645	ENOG4105BZG	amino acid carrier protein
HPY08_02650	ENOG4105D1Q	UPF0246 protein
HPY08_02660	ENOG4105EYA	deoxyribonuclease
HPY08_02665	ENOG4105D9N	nucleoside
HPY08_02675	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HPY08_02680	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HPY08_02685	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HPY08_02690	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY08_02700	ENOG4105EAC	phosphoserine phosphatase
HPY08_02710	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPY08_02715	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY08_02720	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY08_02725	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY08_02735	ENOG4105CNT	hydrolase family 2
HPY08_02740	ENOG41060NJ	transcriptional regulator
HPY08_02745	ENOG4108Y51	tRNA-binding protein
HPY08_02760	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY08_02765	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY08_02775	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HPY08_02780	ENOG4105X2V	dna damage-inducible protein
HPY08_02795	ENOG4105DSY	exodeoxyribonuclease V, gamma
HPY08_02800	ENOG4107QKA	exodeoxyribonuclease V beta
HPY08_02805	ENOG4107QYX	exodeoxyribonuclease v alpha
HPY08_02815	ENOG4107QZM	n-acetylglutamate synthase
HPY08_02825	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HPY08_02830	ENOG4105CUZ	uba thif-type nad fad binding protein
HPY08_02835	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HPY08_02840	ENOG4105C9B	Cysteine desulfurase
HPY08_02845	ENOG4107S0N	DJ-1 family
HPY08_02850	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPY08_02855	ENOG4105DRB	nucleoside-specific channel-forming protein
HPY08_02865	ENOG4105K6V	RNA polymerase
HPY08_02875	ENOG4105EYM	Major Facilitator superfamily
HPY08_02880	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY08_02890	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY08_02895	ENOG4105M85	Bola protein
HPY08_02900	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY08_02905	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY08_02910	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY08_02915	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY08_02920	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY08_02925	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HPY08_02930	ENOG4105CJ2	(LipO)protein
HPY08_02950	ENOG4105BZU	Histidine kinase
HPY08_02955	ENOG4105C8J	)-transporter
HPY08_02965	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY08_02970	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY08_02975	ENOG4105CIN	aminoacyl-histidine dipeptidase
HPY08_02980	ENOG4105C7N	Xanthine uracil vitamin C permease
HPY08_02985	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HPY08_02990	ENOG4108DJV	Fermentation respiration switch protein
HPY08_02995	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HPY08_03000	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPY08_03005	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPY08_03010	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPY08_03015	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY08_03030	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HPY08_03035	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HPY08_03040	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HPY08_03045	ENOG4108ZAI	phosphatidylglycerophosphatase a
HPY08_03050	ENOG4108T8E	UPF0325 protein
HPY08_03055	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HPY08_03060	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPY08_03065	ENOG4105CE9	30S ribosomal protein S2
HPY08_03070	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HPY08_03075	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPY08_03080	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPY08_03085	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPY08_03090	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPY08_03095	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPY08_03100	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPY08_03110	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HPY08_03115	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY08_03120	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HPY08_03125	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY08_03130	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY08_03135	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY08_03140	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPY08_03145	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HPY08_03150	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HPY08_03155	ENOG4105N7H	Cytochrome
HPY08_03160	ENOG4105PY6	Phenolic acid decarboxylase
HPY08_03165	ENOG4108YZA	Nitrogen regulatory protein pii
HPY08_03170	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HPY08_03175	ENOG4105E9H	Lytic Murein transglycosylase
HPY08_03180	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPY08_03185	ENOG4105D1A	Methyltransferase
HPY08_03190	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY08_03195	ENOG4107RZZ	dna polymerase iii epsilon subunit
HPY08_03205	ENOG4107QPN	acyl-Coa dehydrogenase
HPY08_03210	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY08_03215	ENOG4105E7A	Glutamine amidotransferase
HPY08_03220	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HPY08_03225	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPY08_03230	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HPY08_03235	ENOG4105BZU	Histidine kinase
HPY08_03240	ENOG4105FE9	pseudouridine synthase
HPY08_03245	ENOG4108DG9	Smr protein MutS2
HPY08_03265	ENOG4105E2D	ec 3.2.1.52
HPY08_03275	ENOG4105C59	p-type ATPase
HPY08_03280	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPY08_03285	ENOG4105UYK	outer membrane protein a
HPY08_03295	ENOG4107RBR	Receptor
HPY08_03300	ENOG4105Q26	Siderophore-interacting protein
HPY08_03305	ENOG4105C0W	non-ribosomal peptide synthetase
HPY08_03340	ENOG4107R88	Chemotaxis protein (CheV)
HPY08_03345	ENOG4105BZU	Histidine kinase
HPY08_03350	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPY08_03355	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPY08_03360	ENOG4105W00	Flagellar hook capping protein
HPY08_03365	ENOG4105BZE	flagellar hook protein, FlgE
HPY08_03370	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPY08_03375	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPY08_03380	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY08_03385	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY08_03390	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPY08_03405	ENOG4105I03	Flagellin
HPY08_03410	ENOG4105I03	Flagellin
HPY08_03495	ENOG4105C3G	gtp-binding protein
HPY08_03500	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPY08_03505	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPY08_03510	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPY08_03515	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HPY08_03520	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPY08_03525	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPY08_03530	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPY08_03535	ENOG4108YY7	Invasion gene expression up-regulator SirB
HPY08_03540	ENOG41063JG	Transcriptional regulator
HPY08_03545	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY08_03550	ENOG4105CGH	5'-nucleotidase
HPY08_03555	ENOG4108Z66	YbaK ebsC protein
HPY08_03560	ENOG4105C2W	permease
HPY08_03570	ENOG4108RS6	transposase
HPY08_03580	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HPY08_03585	ENOG4105K89	arsenate reductase
HPY08_03590	ENOG4105ERG	peptidase m48, ste24p
HPY08_03605	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_03610	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY08_03625	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY08_03645	ENOG4105KUZ	arsenate reductase
HPY08_03660	ENOG4105QZU	Inner membrane protein YfeZ
HPY08_03665	ENOG4105EZR	dyp-type peroxidase family protein
HPY08_03670	ENOG4105I03	Flagellin
HPY08_03675	ENOG4105I03	Flagellin
HPY08_03680	ENOG4105I03	Flagellin
HPY08_03685	ENOG41063QE	flagellar protein FlaG
HPY08_03690	ENOG4107W9T	flagellar hook-associated
HPY08_03700	ENOG4105MQ3	flagellar protein FliS
HPY08_03710	ENOG4105BZU	Histidine kinase
HPY08_03720	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HPY08_03725	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPY08_03730	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY08_03740	ENOG4108JIR	Flagellum-specific ATP synthase
HPY08_03760	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY08_03765	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY08_03770	ENOG4105DD5	Flagellar motor switch protein
HPY08_03775	ENOG4105VTB	flagellar biosynthesis protein fliO
HPY08_03780	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPY08_03785	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPY08_03790	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPY08_03795	ENOG4105D00	flagellar biosynthetic protein flhB
HPY08_03800	ENOG4108DG9	Smr protein MutS2
HPY08_03805	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HPY08_03810	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPY08_03815	ENOG4105EN6	Membrane
HPY08_03820	ENOG4108BPE	-transporting atpase
HPY08_03825	ENOG4105MH2	YfcL protein
HPY08_03830	ENOG4105Q8W	reductase
HPY08_03835	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HPY08_03840	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY08_03845	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HPY08_03850	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY08_03855	ENOG41090R7	Ferric uptake
HPY08_03865	ENOG4105CMU	LysR family (Transcriptional regulator
HPY08_03870	ENOG4105VAW	lrga family
HPY08_03875	ENOG41067MG	lrgb family
HPY08_03880	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY08_03890	ENOG4105EV9	Alpha Beta Hydrolase
HPY08_03895	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HPY08_03900	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HPY08_03910	ENOG4107QNR	UPF0135 protein
HPY08_03915	ENOG4105BZN	citrate synthase
HPY08_03920	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HPY08_03925	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HPY08_03930	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HPY08_03935	ENOG4105E33	succinate dehydrogenase
HPY08_03940	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPY08_03945	ENOG4105C7S	Dehydrogenase
HPY08_03950	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HPY08_03955	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HPY08_03960	ENOG4105FAV	ABC, transporter
HPY08_03965	ENOG4105FDK	ABC transporter
HPY08_03970	ENOG4105NXV	High-affinity zinc uptake system protein
HPY08_03975	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HPY08_03980	ENOG4105XFK	Ferrous iron transport protein A
HPY08_04000	ENOG4105C75	arginyL-tRNA synthetase
HPY08_04010	ENOG4108JQM	Insulinase (Peptidase family M16)
HPY08_04015	ENOG4108BY2	phosphohistidine phosphatase
HPY08_04020	ENOG4105D7B	Flagellar biosynthesis protein flha
HPY08_04025	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HPY08_04035	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY08_04040	ENOG4108VYJ	response regulator receiver protein
HPY08_04045	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HPY08_04055	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY08_04060	ENOG4107QJE	Chromosome Partitioning Protein
HPY08_04070	ENOG4108V3W	Chemotaxis protein, CheW
HPY08_04080	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HPY08_04085	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HPY08_04090	ENOG41060IM	Heme exporter protein
HPY08_04095	ENOG41067VX	Heme exporter protein
HPY08_04100	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HPY08_04105	ENOG4105DA4	cytochrome c-type biogenesis protein
HPY08_04110	ENOG4107QX9	Thiol disulfide interChange protein
HPY08_04115	ENOG4108M1T	Cytochrome c-type biogenesis protein
HPY08_04125	ENOG410903C	(LipO)protein
HPY08_04140	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY08_04145	ENOG4105M2J	Glutaredoxin
HPY08_04150	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY08_04155	ENOG4105DGU	Histone deacetylase
HPY08_04170	ENOG4105E68	Sulfatase
HPY08_04175	ENOG4105YDX	UPF0352 protein
HPY08_04180	ENOG4106V8H	Nucleoid-associated protein
HPY08_04190	ENOG4105DFD	Na H antiporter
HPY08_04195	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY08_04200	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPY08_04205	ENOG4105C0A	alcohol dehydrogenase
HPY08_04215	ENOG4105CHH	sulfate transporter
HPY08_04220	ENOG4105C03	ribonuclease
HPY08_04225	ENOG4105EI2	Pseudouridine synthase
HPY08_04230	ENOG4108UHJ	MAF-like protein
HPY08_04235	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HPY08_04240	ENOG4105VGS	50s ribosomal protein l32
HPY08_04245	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HPY08_04250	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY08_04255	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HPY08_04260	ENOG4105CHR	reductase
HPY08_04265	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPY08_04270	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY08_04275	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HPY08_04280	ENOG4105HHA	aminodeoxychorismate lyase
HPY08_04285	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPY08_04290	ENOG4107QRG	dna polymerase iii
HPY08_04295	ENOG4105F8V	Hydrolase, tatD family
HPY08_04300	ENOG4105CI1	PTS System
HPY08_04310	ENOG4105C8J	)-transporter
HPY08_04325	ENOG4108NRW	Phospholipase, patatin family
HPY08_04330	ENOG4105CA9	Pyruvate kinase
HPY08_04335	ENOG4105DAG	ROK family
HPY08_04355	ENOG4105DHI	Methyltransferase
HPY08_04365	ENOG4105DSB	aldose 1-epimerase
HPY08_04370	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY08_04375	ENOG4105E0X	reductase
HPY08_04385	ENOG4105VUT	cytoplasmic protein
HPY08_04390	ENOG4105HDK	L-asparaginase
HPY08_04395	ENOG4105D07	Signal peptide peptidase, SppA
HPY08_04400	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY08_04405	ENOG4105CIY	formyltetrahydrofolate deformylase
HPY08_04415	ENOG4105DVT	helicase
HPY08_04420	ENOG41072GX	Peptidase M22 Glycoprotease
HPY08_04435	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY08_04440	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY08_04445	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HPY08_04460	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY08_04465	ENOG4105DK2	UPF0207 protein
HPY08_04470	ENOG4105CHM	Aminotransferase
HPY08_04475	ENOG4105E4F	Isochorismate synthase
HPY08_04480	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPY08_04485	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HPY08_04490	ENOG4108IPT	Naphthoate synthase
HPY08_04500	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY08_04505	ENOG4105DKK	Benzoate
HPY08_04510	ENOG4107S74	Lysophospholipid transporter LplT
HPY08_04535	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HPY08_04540	ENOG4107QMS	site-determining protein
HPY08_04545	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HPY08_04550	ENOG4105VNG	YcgL domain-containing protein
HPY08_04555	ENOG4105CVE	Lytic murein transglycosylase
HPY08_04560	ENOG4105JQN	Transcriptional regulator
HPY08_04565	ENOG4105D9N	nucleoside
HPY08_04570	ENOG4105CUW	cytochrome C-TYPE protein
HPY08_04575	ENOG4107QY8	reductase
HPY08_04585	ENOG4105JQN	Transcriptional regulator
HPY08_04605	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HPY08_04640	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPY08_04650	ENOG4105BZU	Histidine kinase
HPY08_04660	ENOG4105CNG	UPF0061 protein
HPY08_04665	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPY08_04670	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HPY08_04675	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY08_04680	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_04695	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPY08_04700	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPY08_04705	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPY08_04710	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HPY08_04715	ENOG4105K70	DNA-binding protein
HPY08_04720	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HPY08_04725	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HPY08_04730	ENOG4105CAT	Cytidine monophosphate kinase
HPY08_04735	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPY08_04740	ENOG4108RS6	transposase
HPY08_04745	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY08_04750	ENOG4105Q4A	inner membrane protein yciS
HPY08_04755	ENOG4105CFV	Tetratricopeptide repeat protein
HPY08_04765	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HPY08_04775	ENOG4107R11	Transcriptional regulator
HPY08_04785	ENOG4105DCF	alanine dehydrogenase
HPY08_04790	ENOG4105EW9	transcriptional regulator AsnC family
HPY08_04795	ENOG4105CNU	cell division protein FtsK
HPY08_04800	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HPY08_04805	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY08_04810	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HPY08_04820	ENOG4108NVR	Methyl-accepting chemotaxis
HPY08_04825	ENOG4105K59	histidine triad (HIT) protein
HPY08_04850	ENOG4105D0Y	UPF0227 protein
HPY08_04855	ENOG4105CEP	NADH dehydrogenase
HPY08_04870	ENOG4106M3D	hemolysin
HPY08_04880	ENOG4108JA2	transcriptioN-repair coupling factor
HPY08_04890	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY08_04895	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY08_04900	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY08_04910	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HPY08_04915	ENOG4105BZ1	(ABC) transporter
HPY08_04920	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HPY08_04925	ENOG4105W49	UPF0434 protein
HPY08_04930	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY08_04935	ENOG4105ED1	spovr family
HPY08_04940	ENOG4106AKX	UPF0229 protein
HPY08_04945	ENOG4105CYN	Serine protein kinase
HPY08_04950	ENOG4105XWI	UPF0304 protein
HPY08_04960	ENOG4105F1A	Pyruvate formate-lyase
HPY08_04965	ENOG4108N3W	hemolysin secretion protein
HPY08_04975	ENOG4105C6N	Formate acetyltransferase
HPY08_04985	ENOG4108JEH	abc transporter atp-binding protein
HPY08_04990	ENOG4105E89	ABC transporter
HPY08_04995	ENOG4105DSP	amino acid AbC transporter
HPY08_05000	ENOG4106YG3	ABC transporter
HPY08_05005	ENOG4105CGK	Exodeoxyribonuclease III
HPY08_05010	ENOG4106428	Protein of unknown function (DUF2496)
HPY08_05015	ENOG4108URS	primosomal replication protein n''
HPY08_05020	ENOG4105EJ9	Membrane
HPY08_05025	ENOG4105DVT	helicase
HPY08_05040	ENOG4105K5B	UPF0225 protein
HPY08_05045	ENOG4105D58	Diguanylate phosphodiesterase
HPY08_05050	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HPY08_05055	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY08_05060	ENOG4105C8N	cysteinyl-tRNA synthetase
HPY08_05065	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPY08_05070	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPY08_05080	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY08_05085	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY08_05095	ENOG4105KJB	cyd operon protein YbgE
HPY08_05100	ENOG4107YD3	Thioesterase
HPY08_05105	ENOG4105E02	MotA TolQ exbB proton channel
HPY08_05110	ENOG4105M8F	Biopolymer transport protein exbD tolR
HPY08_05120	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HPY08_05125	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HPY08_05135	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HPY08_05145	ENOG4105BZU	Histidine kinase
HPY08_05150	ENOG4108RNS	Exports L-alanine (By similarity)
HPY08_05155	ENOG4105EIP	mannose-6-phosphate isomerase
HPY08_05160	ENOG4105DM4	PTS System
HPY08_05165	ENOG4106R3P	AraC family transcriptional regulator
HPY08_05175	ENOG4108YRF	PTS System
HPY08_05180	ENOG4105DM4	PTS System
HPY08_05185	ENOG4105DM4	PTS System
HPY08_05195	ENOG4105C26	Dehydrogenase
HPY08_05200	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HPY08_05205	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY08_05215	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY08_05250	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HPY08_05260	ENOG4105DY2	Paraquat-inducible protein b
HPY08_05265	ENOG4105F1S	paraquat-inducible protein a
HPY08_05290	ENOG4108R86	Transcriptional regulator
HPY08_05295	ENOG4105C26	Dehydrogenase
HPY08_05300	ENOG4105MTM	Protein of unknown function (DUF1496)
HPY08_05310	ENOG41067SE	Tetr family transcriptional regulator
HPY08_05315	ENOG4107QPN	acyl-Coa dehydrogenase
HPY08_05325	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPY08_05335	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HPY08_05345	ENOG4105RKX	Protein of unknown function (DUF2498)
HPY08_05350	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY08_05355	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY08_05360	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPY08_05380	ENOG4105HP8	regulator of competence-specific genes
HPY08_05385	ENOG4105ETE	Transcriptional regulator (LacI family
HPY08_05390	ENOG4108SBI	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY08_05395	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HPY08_05400	ENOG4107S90	membrAne
HPY08_05405	ENOG4106371	Methyltransferase
HPY08_05410	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HPY08_05415	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HPY08_05425	ENOG4105EW9	transcriptional regulator AsnC family
HPY08_05430	ENOG4108VP3	Lysine exporter protein (LysE YggA)
HPY08_05435	ENOG4105CCT	upf0313 protein
HPY08_05460	ENOG4105DZ2	Transcriptional regulator
HPY08_05465	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HPY08_05475	ENOG4105K9H	YciI-like protein
HPY08_05480	ENOG4105NAU	thioesterase Superfamily protein
HPY08_05495	ENOG4105GFG	DUF218 domain
HPY08_05500	ENOG4107SRH	Nad-dependent epimerase dehydratase
HPY08_05510	ENOG4105TMB	Formate nitrite transporter
HPY08_05525	ENOG4107QY8	reductase
HPY08_05540	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HPY08_05555	ENOG4108JQ2	peptide transport system atp-binding protein
HPY08_05560	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HPY08_05565	ENOG4108EU3	peptide transport system, permease
HPY08_05570	ENOG4108I5W	peptide transport system, permease protein
HPY08_05575	ENOG4108J59	Extracellular solute-binding protein, family 5
HPY08_05580	ENOG4105E51	psp operon transcriptional activator
HPY08_05585	ENOG41087YS	Phage shock protein A
HPY08_05600	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPY08_05615	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HPY08_05620	ENOG4105C28	cystathionine
HPY08_05630	ENOG4105C8J	)-transporter
HPY08_05635	ENOG4108W1A	pseudouridine synthase
HPY08_05640	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HPY08_05645	ENOG4108VGW	abc transporter atp-binding protein
HPY08_05650	ENOG4105CXZ	ABC transporter, permease
HPY08_05655	ENOG4105VNH	ABC transporter solute-binding protein
HPY08_05665	ENOG4105XZD	Fe-S protein
HPY08_05675	ENOG4105C44	Serine transporter
HPY08_05685	ENOG4105CJW	magnesium transporter
HPY08_05695	ENOG4105BZU	Histidine kinase
HPY08_05705	ENOG4105KXC	Collagenase
HPY08_05740	ENOG4108N3W	hemolysin secretion protein
HPY08_05755	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPY08_05775	ENOG4105CFI	type iii restriction protein res subunit
HPY08_05780	ENOG4105I08	Pseudouridine synthase
HPY08_05785	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY08_05795	ENOG4105CGD	Nad-dependent epimerase dehydratase
HPY08_05800	ENOG4105UQX	Mate efflux family protein
HPY08_05805	ENOG4108I0Y	(ABC) transporter
HPY08_05820	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY08_05830	ENOG4105E3Q	saccharopine dehydrogenase
HPY08_05835	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HPY08_05840	ENOG4105CDV	Ompa motb domain protein
HPY08_05845	ENOG4105DFG	type I secretion outer membrane protein
HPY08_05885	ENOG4108VKG	metal-dependent hydrolase
HPY08_05925	ENOG4107V40	secretion protein, HlyD family
HPY08_05940	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY08_05945	ENOG4106YYS	transcriptional regulatory protein
HPY08_05955	ENOG4107R88	Chemotaxis protein (CheV)
HPY08_06005	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPY08_06010	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPY08_06015	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPY08_06025	ENOG4105C7K	acetolactate synthase
HPY08_06030	ENOG4107FQX	Alpha-acetolactate decarboxylase
HPY08_06045	ENOG4108TWJ	NADH dehydrogenase subunit 5
HPY08_06050	ENOG4105DUM	transcriptional regulator, lysR family
HPY08_06070	ENOG4105V0I	UPF0267 protein
HPY08_06085	ENOG4105C9Q	fumarate hydratase class II
HPY08_06095	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY08_06100	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY08_06105	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY08_06110	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY08_06115	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY08_06125	ENOG4107QZV	Type I secretion membrane fusion protein
HPY08_06145	ENOG4106MXH	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY08_06160	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY08_06170	ENOG4105CS2	ec 3.2.1.21
HPY08_06175	ENOG4105DDV	Transcriptional regulator (LacI family
HPY08_06180	ENOG4105M4H	endoribonuclease L-psp
HPY08_06185	ENOG4105XEP	YhcH YjgK YiaL family protein
HPY08_06190	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HPY08_06195	ENOG4105E98	transcriptional regulator DeoR family
HPY08_06200	ENOG4108IJ9	(ABC) transporter
HPY08_06205	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HPY08_06210	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HPY08_06235	ENOG4109015	Biopolymer transport protein exbD tolR
HPY08_06240	ENOG41067XB	TonB family
HPY08_06260	ENOG4107QI1	Mate efflux family protein
HPY08_06280	ENOG4107TT5	NLP P60 protein
HPY08_06285	ENOG4108N3W	hemolysin secretion protein
HPY08_06295	ENOG4106IUH	DTW domain containing protein
HPY08_06300	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HPY08_06315	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY08_06320	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HPY08_06325	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY08_06330	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HPY08_06340	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_06345	ENOG4105BZU	Histidine kinase
HPY08_06350	ENOG4105C5H	ABC transporter
HPY08_06355	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPY08_06375	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY08_06385	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY08_06390	ENOG4105QAX	Iron-sulfur
HPY08_06405	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HPY08_06410	ENOG4108VPT	UPF0234 protein
HPY08_06415	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY08_06430	ENOG4105QNR	S1 RNA binding domain protein
HPY08_06440	ENOG4105DY2	Paraquat-inducible protein b
HPY08_06445	ENOG4105H2K	paraquat-inducible protein a
HPY08_06450	ENOG4105BZ1	(ABC) transporter
HPY08_06455	ENOG4108ZGC	gaf domain protein
HPY08_06460	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HPY08_06465	ENOG4105CN1	protease
HPY08_06475	ENOG4105CD8	aminopeptidase N
HPY08_06485	ENOG4105C7I	Dehydrogenase
HPY08_06490	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPY08_06495	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HPY08_06500	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HPY08_06510	ENOG4105C5H	ABC transporter
HPY08_06525	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HPY08_06530	ENOG4105DAN	ATP-dependent protease
HPY08_06535	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
HPY08_06610	ENOG4105EUK	rtx toxin RtxA
HPY08_06615	ENOG4108RC6	RTX toxin
HPY08_06640	ENOG4105BZU	Histidine kinase
HPY08_06655	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HPY08_06670	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HPY08_06680	ENOG4105C59	p-type ATPase
HPY08_06695	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HPY08_06700	ENOG4105Q9Y	Universal stress protein
HPY08_06710	ENOG4108RS6	transposase
HPY08_06715	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HPY08_06735	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY08_06745	ENOG4105D38	putrescine abc transporter
HPY08_06750	ENOG4108HM4	ABC transporter
HPY08_06755	ENOG4107RUE	extracellular solute-binding protein family 1
HPY08_06770	ENOG4105BZG	amino acid carrier protein
HPY08_06775	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY08_06805	ENOG4105CS6	Rhs element vgr protein
HPY08_06810	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY08_06815	ENOG4105CTD	carboxy-peptidase
HPY08_06835	ENOG4105C1J	atp-dependent rna helicase
HPY08_06845	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY08_06850	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY08_06855	ENOG4105EJC	lysr family transcriptional regulator
HPY08_06865	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HPY08_06870	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HPY08_06875	ENOG4105R8A	Heat shock protein
HPY08_06885	ENOG4105CQ7	ATP-dependent helicase
HPY08_06905	ENOG4105BZU	Histidine kinase
HPY08_06915	ENOG4105CFG	Acts as a chaperone (By similarity)
HPY08_06920	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY08_06925	ENOG4105BZU	Histidine kinase
HPY08_06935	ENOG4105BZU	Histidine kinase
HPY08_06955	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HPY08_06960	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HPY08_06965	ENOG410667J	hydrolase
HPY08_06975	ENOG4107QXX	ABC transporter
HPY08_06980	ENOG4105EZ7	amino acid ABC transporter
HPY08_06985	ENOG4105DRP	amino acid AbC transporter
HPY08_06990	ENOG4105CDA	abc transporter atp-binding protein
HPY08_06995	ENOG4108MN8	Membrane
HPY08_07000	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HPY08_07005	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HPY08_07010	ENOG4105DR4	Methyltransferase
HPY08_07020	ENOG4106TD9	Diguanylate cyclase
HPY08_07030	ENOG4105BZU	Histidine kinase
HPY08_07035	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY08_07040	ENOG4108RXX	maleylacetoacetate isomerase
HPY08_07050	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HPY08_07055	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPY08_07060	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY08_07075	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY08_07080	ENOG4105C7F	AcnD-accessory protein PrpF
HPY08_07085	ENOG4108I0Z	Aconitate hydratase
HPY08_07090	ENOG4105BZN	citrate synthase
HPY08_07095	ENOG4105CR4	methylisocitrate lyase
HPY08_07125	ENOG4108RS6	transposase
HPY08_07130	ENOG4108PTX	LysR family Transcriptional regulator
HPY08_07135	ENOG4105D05	Receptor
HPY08_07160	ENOG4105EFX	secretion protein, HlyD family
HPY08_07175	ENOG4107SDZ	Galactoside transport system permease protein mglC
HPY08_07180	ENOG4105C2J	ABC transporter
HPY08_07205	ENOG4107EXC	regulatoR
HPY08_07210	ENOG4105GR3	Histidine kinase
HPY08_07215	ENOG4105RW8	MltA-interacting MipA family protein
HPY08_07220	ENOG4108MJ5	VirK protein
HPY08_07225	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_07230	ENOG4105BZU	Histidine kinase
HPY08_07235	ENOG4105C8P	)-transporter
HPY08_07240	ENOG4108NVR	Methyl-accepting chemotaxis
HPY08_07245	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY08_07260	ENOG4105D9U	N-acetyltransferase
HPY08_07265	ENOG4108JU8	Transcriptional regulator
HPY08_07275	ENOG4105CM6	amino acid regulated cytosolic protein
HPY08_07290	ENOG4105CRQ	synthase (Component I)
HPY08_07295	ENOG4105P8F	nudix hydrolase
HPY08_07300	ENOG4105C44	Serine transporter
HPY08_07305	ENOG4105EJQ	L-serine dehydratase
HPY08_07310	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HPY08_07315	ENOG4108N3W	hemolysin secretion protein
HPY08_07320	ENOG4105C5S	asparaginyl-tRNA synthetase
HPY08_07325	ENOG4105DWF	phosphomethylpyrimidine kinase
HPY08_07330	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY08_07335	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY08_07345	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HPY08_07350	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_07355	ENOG4105DJ9	glucan biosynthesis protein
HPY08_07360	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HPY08_07365	ENOG4105C94	Transporter
HPY08_07370	ENOG41067TZ	transcriptional regulator, MarR family
HPY08_07385	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY08_07395	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY08_07410	ENOG4105C5X	domain protein
HPY08_07415	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HPY08_07445	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HPY08_07455	ENOG4105S8Q	sugar efflux transporter
HPY08_07465	ENOG4105C72	UPF0176 protein
HPY08_07470	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY08_07475	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPY08_07480	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY08_07485	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY08_07490	ENOG4107QK7	reductase
HPY08_07515	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_07530	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HPY08_07535	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HPY08_07550	ENOG4108YZT	Adenosylcobinamide kinase
HPY08_07555	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HPY08_07560	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HPY08_07565	ENOG4105E0X	reductase
HPY08_07570	ENOG4108ETY	sodium dicarboxylate symporter
HPY08_07575	ENOG4105CJB	Exodeoxyribonuclease I
HPY08_07580	ENOG4105VAW	lrga family
HPY08_07585	ENOG41067MG	lrgb family
HPY08_07615	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY08_07620	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HPY08_07625	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPY08_07665	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPY08_07670	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY08_07675	ENOG4105CQ2	DNA polymerase
HPY08_07680	ENOG4105BZU	Histidine kinase
HPY08_07690	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY08_07695	ENOG4108W5H	UPF0263 protein
HPY08_07705	ENOG4105CZE	histidine utilization repressor
HPY08_07710	ENOG4105CI2	imidazolone-5-propionate hydrolase
HPY08_07715	ENOG41088SP	formiminoglutamate hydrolase
HPY08_07720	ENOG4105CGP	Urocanate hydratase
HPY08_07725	ENOG4105C84	Histidine ammonia-lyase
HPY08_07735	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
HPY08_07745	ENOG4105CQB	FAD linked oxidase domain protein
HPY08_07760	ENOG4108ZG0	Ompa motb domain protein
HPY08_07780	ENOG4105C8V	SAICAR synthetase
HPY08_07790	ENOG4107R1I	NAD-dependent malic enzyme
HPY08_07800	ENOG4107GZ4	SanA protein
HPY08_07805	ENOG4105BZU	Histidine kinase
HPY08_07810	ENOG4105C9B	Cysteine desulfurase
HPY08_07820	ENOG4105C3M	thioredoxin reductase
HPY08_07825	ENOG4108JJ9	ABC, transporter
HPY08_07830	ENOG4108JJ8	(ABC) transporter
HPY08_07835	ENOG4105FE9	pseudouridine synthase
HPY08_07840	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPY08_07845	ENOG4105DB7	PHP domain protein
HPY08_07855	ENOG4105CRQ	synthase (Component I)
HPY08_07860	ENOG4105DDQ	anthranilate synthase
HPY08_07865	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPY08_07870	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPY08_07875	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPY08_07880	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPY08_07885	ENOG4105CK2	sodium dicarboxylate symporter
HPY08_07890	ENOG4107104	thymidine kinase
HPY08_07895	ENOG4105C9M	aspartyl-trna synthetase
HPY08_07900	ENOG41081XQ	Conserved Protein
HPY08_07905	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HPY08_07910	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HPY08_07915	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY08_07930	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPY08_07940	ENOG4105CUX	Signal transduction histidine kinase
HPY08_07965	ENOG4105DWU	Membrane
HPY08_07975	ENOG4105DY8	decarboxylase
HPY08_07980	ENOG4106KNT	transcriptional regulator
HPY08_07985	ENOG4105C0A	alcohol dehydrogenase
HPY08_07990	ENOG41090BQ	Glutaredoxin
HPY08_07995	ENOG4105D0C	transport protein
HPY08_08000	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY08_08005	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPY08_08010	ENOG4105VEQ	Cold shock protein
HPY08_08020	ENOG4108R99	pseudouridine synthase
HPY08_08025	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HPY08_08030	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPY08_08035	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY08_08040	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HPY08_08045	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPY08_08050	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPY08_08055	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPY08_08060	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPY08_08065	ENOG4107S6Z	Na H antiporter
HPY08_08075	ENOG4107RE1	Inosine-guanosine kinase
HPY08_08080	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPY08_08085	ENOG41075W9	High frequency lysogenization protein HflD homolog
HPY08_08090	ENOG4107QTF	adenylosuccinate lyase
HPY08_08100	ENOG4105RHG	
HPY08_08110	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HPY08_08125	ENOG4107FW0	short-chain dehydrogenase reductase
HPY08_08135	ENOG4105D0M	Protease HtpX homolog
HPY08_08145	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HPY08_08150	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HPY08_08155	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY08_08160	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HPY08_08165	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HPY08_08170	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPY08_08175	ENOG4105D1H	recombination factor protein RarA
HPY08_08185	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY08_08190	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HPY08_08195	ENOG4105BZU	Histidine kinase
HPY08_08200	ENOG4108JJB	ABC transporter
HPY08_08205	ENOG4105C7J	ABC transporter, permease
HPY08_08215	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY08_08220	ENOG4105PQ6	UPF0208 membrane protein
HPY08_08225	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY08_08230	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HPY08_08235	ENOG4105CHF	Glutathione S-transferase
HPY08_08240	ENOG4108JQ7	(ABC) transporter
HPY08_08245	ENOG4105C3U	ABC transporter
HPY08_08250	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY08_08255	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY08_08260	ENOG4107QSI	ABC, transporter
HPY08_08275	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_08280	ENOG4105BZU	Histidine kinase
HPY08_08285	ENOG4105BZU	Histidine kinase
HPY08_08290	ENOG4105BZU	Histidine kinase
HPY08_08300	ENOG4107YTP	response regulator receiver protein
HPY08_08315	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY08_08330	ENOG4108V1U	phospholipid-binding protein
HPY08_08355	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY08_08360	ENOG41082YX	Transcriptional regulator, arsr family
HPY08_08380	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
HPY08_08385	ENOG4108JJA	ABC, transporter
HPY08_08475	ENOG4105BZU	Histidine kinase
HPY08_08495	ENOG4105C29	acyl-CoA thioesterase
HPY08_08500	ENOG4108XM1	transcriptional regulator AsnC family
HPY08_08510	ENOG4105ERU	peptidase
HPY08_08515	ENOG4105UBK	short-chain dehydrogenase reductase
HPY08_08520	ENOG4108ZZ3	UPF0260 protein
HPY08_08525	ENOG4105KRS	Proteinase inhibitor
HPY08_08530	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HPY08_08535	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HPY08_08540	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HPY08_08545	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPY08_08550	ENOG4105WD1	Membrane
HPY08_08555	ENOG4105I93	response regulator
HPY08_08560	ENOG4105EJC	lysr family transcriptional regulator
HPY08_08565	ENOG41069NU	Nitroreductase
HPY08_08570	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY08_08575	ENOG4105CHU	acetyl-coa acetyltransferase
HPY08_08590	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY08_08595	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY08_08605	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HPY08_08610	ENOG4108GAE	asmA family
HPY08_08615	ENOG4105DBI	uridine monophosphokinase
HPY08_08620	ENOG4105D1F	ATP-binding protein
HPY08_08625	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPY08_08635	ENOG4108I5U	Uridine phosphorylase
HPY08_08650	ENOG4105BZU	Histidine kinase
HPY08_08655	ENOG4108ZAF	Molybdopterin
HPY08_08660	ENOG4105M00	molybdopterin converting factor, subunit 1
HPY08_08665	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY08_08670	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HPY08_08675	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY08_08680	ENOG4105CHW	UPF0052 protein
HPY08_08690	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_08695	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HPY08_08710	ENOG4108R3D	Electron transport complex
HPY08_08730	ENOG4105DZB	Electron transport complex
HPY08_08735	ENOG4105CSM	endonuclease III
HPY08_08740	ENOG4108UYE	Lactoylglutathione lyase
HPY08_08745	ENOG4106WH9	Protein of unknown function (DUF2753)
HPY08_08750	ENOG4105EIY	sodium-type flagellar protein motY
HPY08_08755	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HPY08_08760	ENOG4105D3Y	Na H antiporter
HPY08_08765	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HPY08_08770	ENOG4105E96	Colicin v production protein
HPY08_08775	ENOG4108S3P	Sporulation domain protein
HPY08_08780	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPY08_08785	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HPY08_08790	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPY08_08805	ENOG4105CI1	PTS System
HPY08_08810	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY08_08815	ENOG4105E2R	ROK family
HPY08_08820	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPY08_08825	ENOG4105CAQ	asparagine synthetase
HPY08_08830	ENOG4105MDZ	Transcriptional activator rfaH
HPY08_08835	ENOG4105DUX	Transporter
HPY08_08840	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPY08_08845	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPY08_08850	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HPY08_08855	ENOG4108TU9	TRANSCRIPTIONal
HPY08_08870	ENOG4108RE9	Phosphodiesterase
HPY08_08875	ENOG4105ECP	epimerase
HPY08_08880	ENOG4105E1F	short-chain dehydrogenase reductase
HPY08_08885	ENOG4107QR8	Thioredoxin
HPY08_08890	ENOG4107QX8	SPFH domain, Band 7 family protein
HPY08_08895	ENOG4105G5H	Membrane
HPY08_08900	ENOG4108Z6Z	Transcriptional regulator
HPY08_08910	ENOG41081QG	Porin Gram-negative type
HPY08_08915	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPY08_08920	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HPY08_08925	ENOG4105EXN	Sulfate transport protein CysZ
HPY08_08930	ENOG4105C6T	cysteine synthase
HPY08_08935	ENOG4105KZ7	phosphocarrier protein hpr
HPY08_08940	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPY08_08945	ENOG4105C5Y	PTS System
HPY08_08950	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY08_08955	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HPY08_08960	ENOG4105C9A	Phoh family
HPY08_08970	ENOG4108JU5	Magnesium and cobalt efflux protein
HPY08_08975	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HPY08_08980	ENOG4107PAI	alpha helical protein
HPY08_08985	ENOG4105C8T	Leucyl-tRNA synthetase
HPY08_08990	ENOG4108U2H	Rare lipoprotein B
HPY08_08995	ENOG4105DJF	DNA polymerase III, delta' subunit
HPY08_09000	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HPY08_09005	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HPY08_09010	ENOG4105CJN	penicillin-binding protein
HPY08_09015	ENOG4105CNI	cell division protein FtsW
HPY08_09020	ENOG4105K6T	rare lipoprotein A
HPY08_09025	ENOG4105DZ1	carboxypeptidase
HPY08_09030	ENOG4108Z43	UPF0250 protein
HPY08_09035	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HPY08_09040	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPY08_09050	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY08_09070	ENOG4105D75	Capsular exopolysaccharide family
HPY08_09075	ENOG4105DAY	polysaccharide export protein
HPY08_09085	ENOG4105D3Q	Sugar transferase
HPY08_09100	ENOG4108MA4	Peptidase M66
HPY08_09115	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HPY08_09125	ENOG4105Q84	sucrose synthase
HPY08_09135	ENOG4105D7W	serine acetyltransferase
HPY08_09155	ENOG4108UW5	maltose o-acetyltransferase
HPY08_09165	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY08_09170	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
HPY08_09175	ENOG4105BZS	acriflavin resistance protein
HPY08_09205	ENOG4105CG3	alpha amylase, catalytic region
HPY08_09210	ENOG4105C5Y	PTS System
HPY08_09215	ENOG4105D4X	repressor
HPY08_09220	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HPY08_09225	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HPY08_09230	ENOG4108UMI	ABC transporter, permease
HPY08_09235	ENOG4105D01	(LipO)protein
HPY08_09240	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HPY08_09245	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HPY08_09250	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HPY08_09260	ENOG4105BZU	Histidine kinase
HPY08_09265	ENOG4105EWT	decarboxylase family
HPY08_09270	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HPY08_09275	ENOG4105M08	Membrane
HPY08_09280	ENOG4105ETT	transcriptional Regulator, LysR family
HPY08_09285	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HPY08_09290	ENOG4106VK6	Flagellar motor protein
HPY08_09295	ENOG4105E14	MotA TolQ exbB proton channel
HPY08_09305	ENOG4105CTB	Polyprenyl synthetase
HPY08_09310	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HPY08_09315	ENOG4105DR9	pseudouridine synthase
HPY08_09320	ENOG4105WP7	tRNA pseudouridine synthase C
HPY08_09335	ENOG4108428	Inherit from COG: -acetyltransferase
HPY08_09345	ENOG4108UPT	UPF0178 protein
HPY08_09350	ENOG4105CFC	Transporter
HPY08_09360	ENOG4105NRA	50s ribosomal protein l31 type b
HPY08_09365	ENOG4108R96	Methyltransferase, YaeB family
HPY08_09370	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPY08_09390	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPY08_09400	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPY08_09405	ENOG4108Z6B	deaminase
HPY08_09410	ENOG4105CFC	Transporter
HPY08_09440	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY08_09445	ENOG4105CFG	Acts as a chaperone (By similarity)
HPY08_09450	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY08_09455	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPY08_09460	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPY08_09465	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY08_09470	ENOG4105VDB	UPF0125 protein
HPY08_09475	ENOG4108Z1B	Cyclase dehydrase
HPY08_09480	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPY08_09510	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPY08_09530	ENOG4105DZ0	fad dependent oxidoreductase
HPY08_09535	ENOG4108Z4U	Ferredoxin
HPY08_09560	ENOG4105CHY	citrate lyase, alpha
HPY08_09565	ENOG4105CI0	Citrate lyase
HPY08_09575	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
HPY08_09580	ENOG4105D2K	citrate carrier protein
HPY08_09590	ENOG4107QSA	Oxaloacetate decarboxylase
HPY08_09595	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY08_09600	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY08_09605	ENOG4106YYS	transcriptional regulatory protein
HPY08_09630	ENOG4105BZG	amino acid carrier protein
HPY08_09635	ENOG4105EUZ	Beta-lactamase domain protein
HPY08_09640	ENOG41064T2	transcriptional regulator, lysR family
HPY08_09650	ENOG4105E0A	ABC, transporter
HPY08_09655	ENOG4105TVJ	transport system, permease
HPY08_09660	ENOG4105DQ5	transport system permease protein
HPY08_09665	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HPY08_09675	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HPY08_09680	ENOG4105E4F	Isochorismate synthase
HPY08_09685	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY08_09690	ENOG4105WQI	isochorismatase
HPY08_09695	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HPY08_09705	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HPY08_09715	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPY08_09720	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY08_09725	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPY08_09740	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPY08_09745	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY08_09750	ENOG4105N21	Membrane
HPY08_09755	ENOG4105CUT	histidyl-tRNA synthetase
HPY08_09760	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPY08_09770	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HPY08_09775	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HPY08_09780	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY08_09785	ENOG4105WVQ	Fe-S assembly protein IscX
HPY08_09790	ENOG4108ZIT	Ferredoxin, 2FE-2S
HPY08_09805	ENOG4108Z4V	iron-sulfur cluster assembly
HPY08_09810	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HPY08_09820	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HPY08_09825	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HPY08_09830	ENOG4105ECY	inositol monophosphatase
HPY08_09835	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY08_09840	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY08_09845	ENOG4105VIE	preprotein translocase, subunit YajC
HPY08_09855	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HPY08_09860	ENOG4105W87	Cbs domain
HPY08_09865	ENOG4108I9X	Isocitrate lyase
HPY08_09870	ENOG4107QP3	malate synthase g
HPY08_09875	ENOG4105C5Q	Transcriptional regulator
HPY08_09880	ENOG4105D3R	alkyl hydroperoxide reductase
HPY08_09885	ENOG4106N3A	copper homeostasis protein cutc
HPY08_09890	ENOG4105CSR	polyphosphate kinase 2
HPY08_09900	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY08_09905	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY08_09910	ENOG4105C8U	phosphate abc transporter
HPY08_09915	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HPY08_09920	ENOG4105C9X	ppx gppa phosphatase
HPY08_09925	ENOG4105DJH	phosphate
HPY08_09930	ENOG4105BZU	Histidine kinase
HPY08_09935	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY08_09945	ENOG4105CFP	Peptidase U32
HPY08_09950	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HPY08_09995	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY08_10000	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPY08_10005	ENOG4105C34	Pseudouridine synthase
HPY08_10010	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY08_10015	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HPY08_10025	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
HPY08_10030	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY08_10040	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
HPY08_10045	ENOG4107SC1	transglycosylase
HPY08_10050	ENOG4105C5H	ABC transporter
HPY08_10065	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY08_10070	ENOG4108HRK	Histidine kinase
HPY08_10075	ENOG4108NEV	two component transcriptional regulator, LytTR family
HPY08_10085	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HPY08_10090	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY08_10110	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPY08_10115	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HPY08_10120	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HPY08_10130	ENOG4105DTN	riboflavin biosynthesis protein ribF
HPY08_10135	ENOG4105CJR	Integral membrane protein (MviN
HPY08_10140	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HPY08_10145	ENOG41080HT	Transcriptional regulator, arsr family
HPY08_10150	ENOG41063Z6	transcriptional regulator, lysR family
HPY08_10160	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HPY08_10165	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPY08_10170	ENOG4105HF0	Membrane
HPY08_10175	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HPY08_10180	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPY08_10185	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
HPY08_10190	ENOG4105CPC	Aldo Keto reductase
HPY08_10200	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_10205	ENOG4105CRK	lysyL-tRNA synthetase
HPY08_10215	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPY08_10225	ENOG4105C1J	atp-dependent rna helicase
HPY08_10235	ENOG4105BZU	Histidine kinase
HPY08_10250	ENOG4108YYD	acetyltransferase
HPY08_10260	ENOG4105BZU	Histidine kinase
HPY08_10295	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HPY08_10305	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HPY08_10310	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPY08_10315	ENOG4105CHV	Transcription elongation factor NusA
HPY08_10320	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HPY08_10335	ENOG4105NTZ	Preprotein translocase subunit SecG
HPY08_10345	ENOG4105EEI	dihydropteroate synthase
HPY08_10350	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPY08_10355	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HPY08_10360	ENOG4105HBR	Rna-binding protein
HPY08_10365	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPY08_10370	ENOG4105FCK	Membrane
HPY08_10375	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HPY08_10380	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY08_10385	ENOG4105DR5	peptidase
HPY08_10400	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HPY08_10405	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPY08_10410	ENOG4105IPI	Membrane
HPY08_10415	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY08_10425	ENOG4107QRA	Extracellular solute-binding protein, family 5
HPY08_10435	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY08_10440	ENOG4105C3U	ABC transporter
HPY08_10445	ENOG4108JQ7	(ABC) transporter
HPY08_10455	ENOG4105RD7	BadF BadG BcrA BcrD
HPY08_10460	ENOG4105E2D	ec 3.2.1.52
HPY08_10465	ENOG4105E2V	Glycosyltransferase 36
HPY08_10475	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY08_10500	ENOG4105XTV	UPF0231 protein
HPY08_10505	ENOG4107QIJ	Aconitate hydratase 2
HPY08_10510	ENOG4105D78	K07001 NTE family protein
HPY08_10515	ENOG4105BZ4	penicillin-binding protein
HPY08_10520	ENOG4105CQ7	ATP-dependent helicase
HPY08_10530	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HPY08_10535	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPY08_10540	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HPY08_10545	ENOG4105DJ0	Poly(A) Polymerase
HPY08_10550	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY08_10555	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPY08_10560	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPY08_10565	ENOG4105E3A	(ABC) transporter
HPY08_10570	ENOG4105DA5	(ABC) transporter
HPY08_10575	ENOG4105CHH	sulfate transporter
HPY08_10580	ENOG41077A9	carbonic anhydrase
HPY08_10585	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPY08_10590	ENOG410630P	Transcriptional regulator
HPY08_10595	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HPY08_10600	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HPY08_10605	ENOG41082RQ	UPF0102 protein
HPY08_10610	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY08_10615	ENOG4105W4M	Transport-associated protein
HPY08_10620	ENOG4105KB2	stringent starvation protein b
HPY08_10625	ENOG4107MKT	Stringent starvation protein a
HPY08_10630	ENOG4105EIX	cytochrome c1
HPY08_10635	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY08_10640	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY08_10645	ENOG4108UJD	30S ribosomal protein S9
HPY08_10650	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPY08_10655	ENOG4105D6Z	AFG1 family ATPase
HPY08_10665	ENOG4105C0H	protease
HPY08_10670	ENOG4105C0H	protease
HPY08_10675	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HPY08_10680	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPY08_10685	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPY08_10690	ENOG4105K5M	30s ribosomal protein S16
HPY08_10695	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY08_10700	ENOG4106KVJ	cytochrome C assembly protein
HPY08_10705	ENOG4108JU6	CBS domain protein
HPY08_10710	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPY08_10715	ENOG4105D9M	gamma-glutamylcysteine synthetase
HPY08_10725	ENOG4105W39	Membrane
HPY08_10735	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY08_10740	ENOG4107QSA	Oxaloacetate decarboxylase
HPY08_10790	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HPY08_10795	ENOG4105CFH	Aspartokinase
HPY08_10800	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPY08_10810	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPY08_10820	ENOG4108IJ6	ABC transporter
HPY08_10825	ENOG4105ECW	sulfate abc transporter
HPY08_10830	ENOG4108I5D	sulfate abc transporter
HPY08_10835	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY08_10840	ENOG4105C6T	cysteine synthase
HPY08_10845	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HPY08_10850	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY08_10855	ENOG4108K5P	(LipO)protein
HPY08_10860	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HPY08_10865	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HPY08_10870	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HPY08_10875	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPY08_10880	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPY08_10890	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPY08_10895	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY08_10900	ENOG4107ZVW	dihydroneopterin aldolase
HPY08_10905	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HPY08_10915	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY08_10920	ENOG4105VCC	30S ribosomal protein S21
HPY08_10925	ENOG4105KTH	gatB Yqey
HPY08_10930	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPY08_10935	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY08_10950	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY08_10955	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HPY08_10960	ENOG410804X	Transcriptional regulator
HPY08_10965	ENOG4105CA9	Pyruvate kinase
HPY08_10970	ENOG4105MPN	Membrane
HPY08_10980	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HPY08_10985	ENOG4105D64	Mechanosensitive ion channel
HPY08_10990	ENOG4105D2N	Aldolase
HPY08_10995	ENOG4105BZA	Phosphoglycerate kinase
HPY08_11000	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY08_11005	ENOG4105D05	Receptor
HPY08_11010	ENOG4108R4R	Iron-regulated virulence regulatory protein
HPY08_11015	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY08_11020	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HPY08_11025	ENOG4105GPY	SprT protein
HPY08_11030	ENOG4105RWS	endonuclease I
HPY08_11035	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HPY08_11040	ENOG4105D7Z	glutathione synthase
HPY08_11045	ENOG4108UJU	UPF0301 protein
HPY08_11050	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPY08_11055	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY08_11065	ENOG4105CZX	twitching motility protein
HPY08_11070	ENOG4105CZX	twitching motility protein
HPY08_11075	ENOG4105DFA	alanine racemase domain protein
HPY08_11080	ENOG4105II7	pyrroline-5-carboxylate reductase
HPY08_11085	ENOG4108VIA	integral membrane protein
HPY08_11100	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HPY08_11105	ENOG4105CSA	Coproporphyrinogen iii oxidase
HPY08_11110	ENOG4105CSV	Glutaminase
HPY08_11115	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HPY08_11120	ENOG4105CEN	a g-specific adenine glycosylase
HPY08_11125	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HPY08_11130	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HPY08_11185	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HPY08_11190	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HPY08_11195	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HPY08_11200	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HPY08_11205	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HPY08_11210	ENOG4105NWN	ApaG protein
HPY08_11215	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HPY08_11225	ENOG4107XM3	UPF0442 protein
HPY08_11230	ENOG4105DWK	Membrane
HPY08_11235	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY08_11240	ENOG4105K46	50S ribosomal protein l27
HPY08_11245	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPY08_11250	ENOG4105EAH	synthase
HPY08_11255	ENOG4105D5Q	Arginine ornithine antiporter
HPY08_11260	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HPY08_11265	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPY08_11270	ENOG4105H1G	trap transporter solute receptor taxi family
HPY08_11280	ENOG41081QV	Universal stress protein
HPY08_11300	ENOG4105CEU	Arginine dihydrolase
HPY08_11305	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HPY08_11315	ENOG4105QD6	exported protein
HPY08_11320	ENOG4105C03	ribonuclease
HPY08_11325	ENOG4108Z03	MAF-like protein
HPY08_11330	ENOG4105VQ7	Rod shape-determining protein MreD
HPY08_11335	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HPY08_11375	ENOG4105X0D	Fimbrial protein
HPY08_11385	ENOG4105D7Q	type ii secretion system
HPY08_11390	ENOG4107QHF	type ii secretion system protein e
HPY08_11425	ENOG41062P1	Diguanylate cyclase phosphodiesterase
HPY08_11430	ENOG4108UUM	single-stranded DNA-binding protein
HPY08_11435	ENOG41086KC	Transcriptional regulator
HPY08_11440	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HPY08_11445	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HPY08_11455	ENOG4105C5R	Aminotransferase
HPY08_11460	ENOG4105CFH	Aspartokinase
HPY08_11465	ENOG4105C3R	Methionine synthase
HPY08_11540	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPY08_11550	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HPY08_11570	ENOG4105P4Z	Phage shock protein G
HPY08_11575	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY08_11580	ENOG4105MYN	Zinc uptake regulation protein
HPY08_11595	ENOG4107QP8	phosphohexose isomerase
HPY08_11600	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HPY08_11605	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY08_11610	ENOG4105CDU	Replicative dna helicase
HPY08_11620	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPY08_11625	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPY08_11630	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HPY08_11635	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPY08_11640	ENOG4108UQY	Iron-storage protein
HPY08_11645	ENOG4105W53	bacterioferritin-associated ferredoxin
HPY08_11650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY08_11655	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY08_11660	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPY08_11675	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPY08_11680	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HPY08_11685	ENOG4105WWK	YheO domain protein
HPY08_11690	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY08_11700	ENOG41069P5	Protein slyX homolog
HPY08_11710	ENOG4105EPW	hflc protein
HPY08_11715	ENOG4107QJR	hflk protein
HPY08_11720	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPY08_11725	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HPY08_11730	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPY08_11735	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HPY08_11740	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HPY08_11745	ENOG4105K8N	protein family UPF0079, ATPase
HPY08_11750	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HPY08_11795	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPY08_11800	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPY08_11805	ENOG4105DJ4	phosphatidylserine decarboxylase
HPY08_11810	ENOG4105C8P	)-transporter
HPY08_11820	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPY08_11825	ENOG41063SB	peptidase
HPY08_11835	ENOG41062JF	Transcriptional regulator
HPY08_11840	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HPY08_11845	ENOG4105E09	nadh pyrophosphatase
HPY08_11850	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HPY08_11855	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY08_11860	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY08_11865	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HPY08_11870	ENOG4108VZM	50s ribosomal protein L10
HPY08_11880	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HPY08_11885	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPY08_11890	ENOG4105PM1	preprotein translocase subunit SecE
HPY08_11895	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY08_11920	ENOG4105CS9	pantothenic acid kinase
HPY08_11925	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPY08_11930	ENOG4105D4A	Cell wall formation (By similarity)
HPY08_11940	ENOG4105JIM	Phosphatidylserine synthase
HPY08_11975	ENOG4107QK7	reductase
HPY08_11985	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HPY08_11995	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HPY08_12005	ENOG4105C1J	atp-dependent rna helicase
HPY08_12010	ENOG4105C9X	ppx gppa phosphatase
HPY08_12015	ENOG4105BZU	Histidine kinase
HPY08_12020	ENOG4105D8G	Major Facilitator superfamily
HPY08_12035	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY08_12040	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HPY08_12045	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HPY08_12050	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HPY08_12055	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY08_12060	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY08_12065	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HPY08_12070	ENOG4105DIQ	Transcriptional regulator
HPY08_12085	ENOG4105C01	Dihydroxy-acid dehydratase
HPY08_12090	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPY08_12095	ENOG4105C6Z	Gluconate
HPY08_12100	ENOG4108UHU	Aldolase
HPY08_12105	ENOG4105E0K	tonB-dependent siderophore receptor
HPY08_12120	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_12125	ENOG4105CXN	decarboxylase
HPY08_12130	ENOG4105D5Q	Arginine ornithine antiporter
HPY08_12135	ENOG4108M3R	transcriptional activator CadC
HPY08_12140	ENOG4105W1Y	Transcriptional regulator
HPY08_12155	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPY08_12165	ENOG4105K70	DNA-binding protein
HPY08_12180	ENOG4105R2J	Conserved Protein
HPY08_12185	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HPY08_12190	ENOG4108RG0	uracil-dna glycosylase
HPY08_12195	ENOG4105CUY	Mechanosensitive ion channel
HPY08_12200	ENOG4105CY0	Metallo-Beta-Lactamase
HPY08_12210	ENOG4105ESV	Glycosyl transferase, family 4
HPY08_12220	ENOG4107QPH	glycogen) synthase
HPY08_12255	ENOG4105DAY	polysaccharide export protein
HPY08_12265	ENOG4108MDC	(LipO)protein
HPY08_12275	ENOG4105E3R	(LipO)protein
HPY08_12285	ENOG4105D3Q	Sugar transferase
HPY08_12330	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HPY08_12355	ENOG4105K64	Glycosyl transferase, family 2
HPY08_12370	ENOG4105EY8	ABC transporter
HPY08_12380	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HPY08_12390	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HPY08_12395	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HPY08_12400	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HPY08_12415	ENOG4107T94	Endo-14-beta-xylanase
HPY08_12420	ENOG4105XA0	heptosyltransferase ii
HPY08_12425	ENOG4108ST3	glycosyltransferase
HPY08_12430	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HPY08_12435	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY08_12440	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HPY08_12455	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
HPY08_12460	ENOG4105DKP	glycosyl transferase, family 9
HPY08_12465	ENOG4106WTF	Glycosyl transferase, family 2
HPY08_12470	ENOG4105M5K	heptosyltransferase
HPY08_12475	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPY08_12480	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPY08_12490	ENOG4105W0E	50S ribosomal protein L33
HPY08_12495	ENOG4105KDC	50s ribosomal protein l28
HPY08_12500	ENOG4105W5Q	DNA repair protein (RadC
HPY08_12505	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_12510	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HPY08_12520	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HPY08_12525	ENOG4105D1S	lipid A biosynthesis
HPY08_12530	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HPY08_12535	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPY08_12540	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPY08_12545	ENOG4105DSJ	YicC domain protein
HPY08_12550	ENOG4108TEB	UPF0114 protein
HPY08_12555	ENOG4105C5Y	PTS System
HPY08_12560	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY08_12565	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HPY08_12570	ENOG4105EHG	Permease protein
HPY08_12600	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPY08_12605	ENOG4105FR1	rard protein
HPY08_12610	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY08_12615	ENOG4108DMH	HTH_ARAC
HPY08_12620	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY08_12625	ENOG4105C4R	Atp-dependent dna helicase
HPY08_12630	ENOG4105DGW	oligopeptidase A
HPY08_12635	ENOG4105D6S	protein involved in catabolism of external DNA
HPY08_12640	ENOG4105DC8	reductase
HPY08_12650	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY08_12655	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY08_12660	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPY08_12700	ENOG4105MPD	Cytochrome
HPY08_12705	ENOG4105C4R	Atp-dependent dna helicase
HPY08_12710	ENOG4105Y7M	Transcriptional regulator, TetR family
HPY08_12715	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPY08_12720	ENOG4105BZS	acriflavin resistance protein
HPY08_12725	ENOG4105W0Z	cytoplasmic protein
HPY08_12730	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HPY08_12735	ENOG4105EMY	transcriptional regulator
HPY08_12805	ENOG4108RR8	protoporphyrinogen oxidase
HPY08_12810	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY08_12815	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPY08_12820	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY08_12825	ENOG4105CHU	acetyl-coa acetyltransferase
HPY08_12830	ENOG4105F52	Transcriptional regulator
HPY08_12835	ENOG4105CZQ	inner membrane transport protein YdhC
HPY08_12845	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPY08_12850	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPY08_12855	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPY08_12860	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPY08_12865	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY08_12870	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY08_12880	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPY08_12885	ENOG410684E	atp synthase
HPY08_12890	ENOG4105FA0	parb-like partition protein
HPY08_12895	ENOG4107QJE	Chromosome Partitioning Protein
HPY08_12900	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPY08_12905	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HPY08_12910	ENOG4105QTB	Flavodoxin
HPY08_12915	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HPY08_12920	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPY08_12930	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HPY08_12945	ENOG4105E5Q	amino acid AbC transporter
HPY08_12950	ENOG4105EAB	amino acid AbC transporter
HPY08_12955	ENOG4106RMF	ParB family
HPY08_12985	ENOG4105CDY	transcriptional regulatory protein
HPY08_12990	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPY08_12995	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_13000	ENOG4108YYI	Protein of unknown function (DUF2810)
HPY08_13005	ENOG41061ZR	Transcriptional regulator
HPY08_13010	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HPY08_13015	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HPY08_13020	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPY08_13025	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY08_13030	ENOG4105CS6	Rhs element vgr protein
HPY08_13055	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY08_13065	ENOG4105C8P	)-transporter
HPY08_13070	ENOG4108Q67	UPF0319 protein
HPY08_13100	ENOG4105EYK	Phosphatidylglycerophosphatase B
HPY08_13110	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HPY08_13135	ENOG4105D6U	Sodium Glutamate Symporter
HPY08_13140	ENOG4105YE1	PilZ domain
HPY08_13155	ENOG4105EFX	secretion protein, HlyD family
HPY08_13160	ENOG4105KK7	inner membrane protein YiaW
HPY08_13165	ENOG4106TD9	Diguanylate cyclase
HPY08_13180	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY08_13185	ENOG4107SEY	Conserved Protein
HPY08_13195	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY08_13200	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HPY08_13210	ENOG4105C1J	atp-dependent rna helicase
HPY08_13215	ENOG4105CUG	Oligopeptidase b
HPY08_13245	ENOG4105CVA	phosphate
HPY08_13250	ENOG4105C8U	phosphate abc transporter
HPY08_13255	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY08_13260	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY08_13275	ENOG4105DWD	nucleoside recognition domain protein
HPY08_13280	ENOG4105CHH	sulfate transporter
HPY08_13290	ENOG4105DR5	peptidase
HPY08_13295	ENOG4105BZU	Histidine kinase
HPY08_13300	ENOG4105EQ2	LysR family Transcriptional regulator
HPY08_13305	ENOG4105E5M	Multidrug resistance protein D
HPY08_13310	ENOG4108Z4X	TRANSCRIPTIONal
HPY08_13325	ENOG4105CK2	sodium dicarboxylate symporter
HPY08_13370	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HPY08_13375	ENOG4105D9R	oxidoreductase
HPY08_13385	ENOG4105BZU	Histidine kinase
HPY08_13390	ENOG4107VXZ	Hydrolase
HPY08_13400	ENOG4105D3G	Pseudouridine synthase
HPY08_13460	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY08_13465	ENOG4108JUB	Transcriptional regulator
HPY08_13490	ENOG4105CS6	Rhs element vgr protein
HPY08_13510	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HPY08_13515	ENOG4105C2J	ABC transporter
HPY08_13520	ENOG4105CNN	ABC, transporter
HPY08_13525	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPY08_13530	ENOG4108RVA	ribokinase
HPY08_13535	ENOG4105ETE	Transcriptional regulator (LacI family
HPY08_13540	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HPY08_13545	ENOG4108I5U	Uridine phosphorylase
HPY08_13555	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPY08_13560	ENOG4105CXY	transporter
HPY08_13575	ENOG4105CQZ	Histidine kinase
HPY08_13580	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY08_13595	ENOG4105D5U	fad dependent oxidoreductase
HPY08_13605	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPY08_13620	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
HPY08_13625	ENOG4105ETE	Transcriptional regulator (LacI family
HPY08_13630	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY08_13635	ENOG4105KJM	monovalent cation h antiporter subunit g
HPY08_13640	ENOG41080TA	Multiple resistance and ph regulation protein f
HPY08_13645	ENOG4105SC1	monovalent cation H antiporter subunit E
HPY08_13650	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HPY08_13655	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HPY08_13660	ENOG4105D65	subunit l
HPY08_13670	ENOG4105Q9Y	Universal stress protein
HPY08_13675	ENOG4105CIC	tryptophan-specific transport protein
HPY08_13690	ENOG4105VRT	cytoplasmic protein
HPY08_13700	ENOG4105BZU	Histidine kinase
HPY08_13705	ENOG4105VEQ	Cold shock protein
HPY08_13720	ENOG4107QVM	von Willebrand factor, type A
HPY08_13740	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPY08_13745	ENOG41069D7	Methyl-accepting chemotaxis
HPY08_13760	ENOG4105D9N	nucleoside
HPY08_13765	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY08_13775	ENOG4108JUA	Transcriptional regulator
HPY08_13780	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY08_13785	ENOG4105VEQ	Cold shock protein
HPY08_13805	ENOG4108UNF	response regulator
HPY08_13815	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HPY08_13820	ENOG4105C5I	Dehydrogenase
HPY08_13840	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY08_13855	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY08_13870	ENOG4105C1J	atp-dependent rna helicase
HPY08_13875	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY08_13880	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HPY08_13885	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HPY08_13890	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY08_13900	ENOG4105BZU	Histidine kinase
HPY08_13910	ENOG4107S6Z	Na H antiporter
HPY08_13915	ENOG4105E5M	Multidrug resistance protein D
HPY08_13925	ENOG4105KUU	lipolytic protein G-D-S-L family
HPY08_13930	ENOG4106M3D	hemolysin
HPY08_13935	ENOG4108N3W	hemolysin secretion protein
HPY08_13940	ENOG4107IFA	Lipase (EC 3.1.1.3)
HPY08_13970	ENOG4105DHS	permease protein
HPY08_13975	ENOG4105CM4	permease protein
HPY08_13980	ENOG4108IPW	abc transporter atp-binding protein
HPY08_14000	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY08_14015	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
HPY08_14020	ENOG4105CVR	type I restriction-modification system
HPY08_14025	ENOG4107XZC	Restriction modification system DNA (Specificity
HPY08_14060	ENOG4105CR8	Transcriptional regulator
HPY08_14075	ENOG4105ETX	regulatoR
HPY08_14105	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HPY08_14115	ENOG410667J	hydrolase
HPY08_14160	ENOG4105CHJ	isochorismatase hydrolase
HPY08_14165	ENOG4105C2I	pirin domain protein
HPY08_14195	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY08_14200	ENOG4105BZU	Histidine kinase
HPY08_14225	ENOG4107QVI	Methyltransferase, type 11
HPY08_14240	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HPY08_14245	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_14255	ENOG4105DZ1	carboxypeptidase
HPY08_14275	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY08_14280	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HPY08_14285	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY08_14295	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HPY08_14305	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPY08_14310	ENOG41082NX	50s ribosomal protein l35
HPY08_14315	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPY08_14360	ENOG4105VXN	addiction module toxin, RelE StbE family
HPY08_14400	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY08_14470	ENOG4105KD7	acetyltransferase
HPY08_14475	ENOG4105WXW	Antirepressor
HPY08_14485	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY08_14540	ENOG4108HYG	acetyltransferase
HPY08_14630	ENOG4105KD7	acetyltransferase
HPY08_14650	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY08_14675	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY08_14700	ENOG4105KD7	acetyltransferase
HPY08_14775	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HPY08_14820	ENOG4108HYG	acetyltransferase
HPY08_14855	ENOG4105YGK	Pfam:UPF0157
HPY08_14885	ENOG4105D9U	N-acetyltransferase
HPY08_14980	ENOG4105YGK	Pfam:UPF0157
HPY08_15000	ENOG4105EST	Metal Dependent Phosphohydrolase
HPY08_15060	ENOG4108HYG	acetyltransferase
HPY08_15185	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HPY08_15190	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY08_15270	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HPY08_15320	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
HPY08_15490	ENOG4108MK9	spermidine N(1)-acetyltransferase
HPY08_15555	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY08_15575	ENOG4105FFM	Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity)
HPY08_15580	ENOG4105D9U	N-acetyltransferase
HPY08_15635	ENOG4105VXN	addiction module toxin, RelE StbE family
HPY08_15725	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY08_15845	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY08_15875	ENOG41080ET	plasmid maintenance system killer protein
HPY08_15880	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
HPY08_15925	ENOG4108RS6	transposase
HPY08_15930	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY08_15935	ENOG4108ZG0	Ompa motb domain protein
HPY08_15940	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_15945	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPY08_15950	ENOG4105D7K	pfkb domain protein
HPY08_15955	ENOG4107R3K	hydrolase
HPY08_15960	ENOG4105ETE	Transcriptional regulator (LacI family
HPY08_15965	ENOG4105C5Y	PTS System
HPY08_16050	ENOG4108RCM	Nitroreductase
HPY08_16055	ENOG41067V3	Antibiotic biosynthesis monooxygenase
HPY08_16060	ENOG4105ETT	transcriptional Regulator, LysR family
HPY08_16070	ENOG4105RA2	Membrane
HPY08_16085	ENOG4108M3J	Dehydrogenase
HPY08_16110	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY08_16120	ENOG4107RHR	regulatoR
HPY08_16125	ENOG4105KHC	sulfurtransferase
HPY08_16135	ENOG4105D06	uba thif-type nad fad binding protein
HPY08_16140	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY08_16145	ENOG4105EUJ	GTP cyclohydrolase i
HPY08_16150	ENOG4105E0X	reductase
HPY08_16155	ENOG4105CKU	formyltetrahydrofolate synthetase
HPY08_16160	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HPY08_16165	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HPY08_16175	ENOG4105PAD	Hydrolase
HPY08_16180	ENOG4105NXH	GreA GreB family elongation factor
HPY08_16185	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HPY08_16210	ENOG4107RCV	ABC transporter, permease
HPY08_16225	ENOG4105DUX	Transporter
HPY08_16250	ENOG4105E43	Extracellular solute-binding protein, family 5
HPY08_16255	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HPY08_16260	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPY08_16265	ENOG4108JQ5	ABC transporter
HPY08_16270	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY08_16285	ENOG4105CYM	Glutathione S-transferase
HPY08_16305	ENOG4105KA0	thioesterase Superfamily protein
HPY08_16325	ENOG4105CWB	LysR family transcriptional Regulator
HPY08_16330	ENOG4105CD5	CoA-binding domain protein
HPY08_16350	ENOG4108ZJT	translation initiation factor, Sui1
HPY08_16355	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY08_16360	ENOG4105CS6	Rhs element vgr protein
HPY08_16395	ENOG4105KT5	UmuD protein
HPY08_16400	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPY08_16485	ENOG4105F8X	type iii restriction
HPY08_16525	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY08_16535	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY08_16540	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY08_16555	ENOG4105BZU	Histidine kinase
HPY08_16565	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY08_16575	ENOG4105BZU	Histidine kinase
HPY08_16605	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HPY08_16610	ENOG4108RS6	transposase
HPY08_16620	ENOG4105DU1	integral membrane protein, terc
HPY08_16625	ENOG4105CGH	5'-nucleotidase
HPY08_16630	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
HPY08_16635	ENOG4108UQ5	membrane protein YcdZ
HPY08_16640	ENOG4105DUM	transcriptional regulator, lysR family
HPY08_16645	ENOG4105TMB	Formate nitrite transporter
HPY08_16655	ENOG4105DS1	cytochrome b561
HPY08_16665	ENOG4105EPM	Diguanylate phosphodiesterase
HPY08_16680	ENOG410607N	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity)
HPY08_16685	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HPY08_16690	ENOG4105C08	Histidine kinase
HPY08_16695	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HPY08_16700	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HPY08_16705	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HPY08_16710	ENOG4105CKI	cobalamin synthesis protein
HPY08_16715	ENOG4105CMQ	Chloride channel
HPY08_16725	ENOG4107KBT	8-Amino-7-oxononanoate synthase
HPY08_16730	ENOG4108MGY	Histidine kinase
HPY08_16735	ENOG4105EYH	Exonuclease
HPY08_16740	ENOG4107RFY	SbcCD D subunit
HPY08_16745	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPY08_16750	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HPY08_16755	ENOG4105DE4	1-phosphofructokinase
HPY08_16760	ENOG4105DM4	PTS System
HPY08_16765	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY08_16770	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY08_16775	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HPY08_16780	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HPY08_16790	ENOG4107VXZ	Hydrolase
HPY08_16795	ENOG4108N3W	hemolysin secretion protein
HPY08_16800	ENOG4105CEE	C4-dicarboxylate transporter
HPY08_16805	ENOG4105EJQ	L-serine dehydratase
HPY08_16810	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY08_16815	ENOG4105BZU	Histidine kinase
HPY08_16830	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY08_16850	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY08_16855	ENOG4108KX4	response regulator
HPY08_16860	ENOG4105BZU	Histidine kinase
HPY08_16865	ENOG4105CXY	transporter
HPY08_16870	ENOG4105C4Y	ABC transporter
HPY08_16875	ENOG4107RCV	ABC transporter, permease
HPY08_16880	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY08_16885	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HPY08_16895	ENOG4105CHU	acetyl-coa acetyltransferase
HPY08_16905	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY08_16910	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY08_16925	ENOG4105BZU	Histidine kinase
HPY08_16930	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY08_16940	ENOG4108I6A	alcohol dehydrogenase
HPY08_16950	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
HPY08_16960	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
HPY08_16965	ENOG4105CXY	transporter
HPY08_16970	ENOG4105CA9	Pyruvate kinase
HPY08_16975	ENOG4105BZU	Histidine kinase
HPY08_16980	ENOG4108SV3	Tmao reductase system periplasmic protein tort
HPY08_16985	ENOG4108Z5K	methylglyoxal synthase
HPY08_16990	ENOG4108RWI	nicotinamidase
HPY08_16995	ENOG41080IJ	Diacylglycerol kinase
HPY08_17000	ENOG41088T4	Helicase IV
HPY08_17005	ENOG4105EM2	membrane
HPY08_17035	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HPY08_17040	ENOG4105E0C	molybdate abc transporter
HPY08_17045	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HPY08_17050	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HPY08_17090	ENOG4105ID8	Transcriptional regulator, ARAC family
HPY08_17100	ENOG4105EYM	Major Facilitator superfamily
HPY08_17105	ENOG4105C0W	non-ribosomal peptide synthetase
HPY08_17130	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY08_17135	ENOG4105C94	Transporter
HPY08_17155	ENOG4105BZ1	(ABC) transporter
HPY08_17160	ENOG4105BZ1	(ABC) transporter
HPY08_17170	ENOG4105BZU	Histidine kinase
HPY08_17175	ENOG4108QGH	periplasmic
HPY08_17185	ENOG41082IR	Excinuclease ABC C subunit domain protein
HPY08_17200	ENOG41090HJ	UPF0265 protein
HPY08_17215	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPY08_17220	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HPY08_17225	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HPY08_17230	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPY08_17235	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY08_17240	ENOG4105K63	Thioredoxin
HPY08_17265	ENOG4105DMR	ABC, transporter
HPY08_17270	ENOG4105GBT	ABC transporter
HPY08_17275	ENOG4106PMH	Extracellular solute-binding protein family 3
HPY08_17280	ENOG4105E5Z	arginine transporter ATP-binding subunit
HPY08_17290	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HPY08_17300	ENOG4108YZ4	nudix hydrolase
HPY08_17305	ENOG4105C5W	Aldolase
HPY08_17310	ENOG4106RE7	Cytochrome
HPY08_17315	ENOG4107XI7	Tetr family transcriptional regulator
HPY08_17320	ENOG4105C1J	atp-dependent rna helicase
HPY08_17330	ENOG4105E0U	tyrosine-specific transport protein
HPY08_17335	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_17340	ENOG4105CMR	udp-glucose 4-epimerase
HPY08_17345	ENOG4105E7W	lamb ycsf family protein
HPY08_17350	ENOG4105P4J	Allophanate hydrolase, subunit 1
HPY08_17355	ENOG4107R7A	Allophanate hydrolase subunit 2
HPY08_17365	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HPY08_17370	ENOG4105CV6	ABC transporter, permease
HPY08_17375	ENOG4108I0Y	(ABC) transporter
HPY08_17385	ENOG4105RKW	reductase (By
HPY08_17400	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY08_17415	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY08_17430	ENOG4107RE1	Inosine-guanosine kinase
HPY08_17435	ENOG4105E0M	Sulfatase
HPY08_17445	ENOG4105C1J	atp-dependent rna helicase
HPY08_17460	ENOG4105CVA	phosphate
HPY08_17470	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HPY08_17475	ENOG4108M1A	Chitin-binding protein
HPY08_17480	ENOG4105D4Y	metalloprotease
HPY08_17495	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HPY08_17505	ENOG4105CJW	magnesium transporter
HPY08_17515	ENOG4105CZK	Aspartate kinase
HPY08_17520	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
HPY08_17525	ENOG4108JPW	Aminotransferase
HPY08_17530	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY08_17535	ENOG41090A4	Pterin carbinolamine dehydratase
HPY08_17540	ENOG4105MIR	Phenylalanine 4-monooxygenase
HPY08_17545	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY08_17560	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY08_17565	ENOG4105EGI	Transcriptional regulator
HPY08_17585	ENOG4105C37	(CBS) domain
HPY08_17590	ENOG4108UKZ	OsmC family
HPY08_17595	ENOG4107YWA	deoxycytidylate deaminase
HPY08_17625	ENOG4105DVH	amino acid
HPY08_17630	ENOG4106TD9	Diguanylate cyclase
HPY08_17640	ENOG4107RGM	aldo keto reductase
HPY08_17645	ENOG4107T9C	Alpha amylase catalytic region
HPY08_17655	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY08_17660	ENOG4108M0H	Extracellular lipase
HPY08_17665	ENOG4107SDU	Methyl-accepting chemotaxis
HPY08_17670	ENOG4105D4Y	metalloprotease
HPY08_17680	ENOG4105EIF	outer membrane protein W
HPY08_17690	ENOG41061WM	D-Alanyl-D-Alanine
HPY08_17695	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY08_17700	ENOG4105VEQ	Cold shock protein
HPY08_17710	ENOG4105BZC	d-serine deaminase
HPY08_17715	ENOG4105W8I	Transcriptional regulator
HPY08_17735	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPY08_17740	ENOG4107RRE	RNA-directed DNA polymerase
HPY08_17745	ENOG4105CPQ	Dehydrogenase
HPY08_17750	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY08_17765	ENOG4105EXG	Transcriptional regulator
HPY08_17770	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HPY08_17795	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY08_17800	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HPY08_17805	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HPY08_17810	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPY08_17835	ENOG4105BZW	Glycerate kinase
HPY08_17840	ENOG4105C6Z	Gluconate
HPY08_17845	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HPY08_17850	ENOG4108NVR	Methyl-accepting chemotaxis
HPY08_17855	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HPY08_17860	ENOG41090JE	Utilization Protein
HPY08_17865	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY08_17870	ENOG4105WQ5	TonB family
HPY08_17875	ENOG41090AP	transport protein
HPY08_17880	ENOG4106GFD	transport protein
HPY08_17890	ENOG4105EHG	Permease protein
HPY08_17895	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY08_17925	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_17930	ENOG4105QVC	MOSC domain-containing protein
HPY08_17930	ENOG4105QVC	MOSC domain-containing protein
HPY08_17935	ENOG4105EKE	dihydroorotase
HPY08_17940	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
HPY08_17945	ENOG4105CKW	Inner membrane protein yedI
HPY08_17955	ENOG4108ESY	Metal dependent phosphohydrolase
HPY08_17960	ENOG4105VEQ	Cold shock protein
HPY08_17975	ENOG4105EQD	regulatoR
HPY08_17985	ENOG4105BZU	Histidine kinase
HPY08_17990	ENOG4105E98	transcriptional regulator DeoR family
HPY08_18005	ENOG4105EG2	ABC transporter, permease
HPY08_18010	ENOG4105D56	permease protein
HPY08_18015	ENOG4107FKK	extracellular solute-binding protein family 1
HPY08_18020	ENOG4108IJ9	(ABC) transporter
HPY08_18025	ENOG4108HK0	-acetyltransferase
HPY08_18040	ENOG4105K8R	UPF0145 protein
HPY08_18045	ENOG41086KC	Transcriptional regulator
HPY08_18050	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HPY08_18060	ENOG4105K56	Transcriptional regulator
HPY08_18065	ENOG4106TD9	Diguanylate cyclase
HPY08_18080	ENOG4105BZU	Histidine kinase
HPY08_18100	ENOG4105ETT	transcriptional Regulator, LysR family
HPY08_18105	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY08_18115	ENOG4105EUB	pirin domain protein
HPY08_18120	ENOG4105NBK	UPF0345 protein
HPY08_18130	ENOG4105E5W	Transporter
HPY08_18140	ENOG4105DAN	ATP-dependent protease
HPY08_18150	ENOG4108JQ5	ABC transporter
HPY08_18155	ENOG4105E89	ABC transporter
HPY08_18160	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_18170	ENOG4105CC0	LysR family Transcriptional regulator
HPY08_18180	ENOG4105DAA	L-lactate
HPY08_18195	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HPY08_18205	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HPY08_18225	ENOG4108RPX	mosc domain containing protein
HPY08_18230	ENOG4105C1J	atp-dependent rna helicase
HPY08_18240	ENOG4105BZ1	(ABC) transporter
HPY08_18250	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY08_18260	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY08_18285	ENOG4105K56	Transcriptional regulator
HPY08_18290	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HPY08_18300	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY08_18305	ENOG4105VW4	glutaredoxin 3
HPY08_18310	ENOG4108P2H	Inner membrane protein YjiG
HPY08_18315	ENOG41074DU	domain protein
HPY08_18320	ENOG4105DN9	Na H antiporter
HPY08_18330	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPY08_18335	ENOG4105D03	DNA-3-methyladenine glycosylase II
HPY08_18340	ENOG4108VGI	doxx family
HPY08_18365	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPY08_18370	ENOG4108RS6	transposase
HPY08_18380	ENOG4107W52	maltose operon periplasmic protein
HPY08_18385	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPY08_18400	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_18415	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_18420	ENOG4105BZU	Histidine kinase
HPY08_18430	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY08_18435	ENOG4105CDA	abc transporter atp-binding protein
HPY08_18445	ENOG4106TNF	Periplasmic binding protein
HPY08_18450	ENOG4105EZ7	amino acid ABC transporter
HPY08_18455	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HPY08_18460	ENOG4105CTS	PTS system mannitol-specific
HPY08_18465	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HPY08_18470	ENOG4105E61	Mannitol repressor protein
HPY08_18475	ENOG4105EP9	oxidoreductase
HPY08_18505	ENOG4108RYK	Nad-dependent epimerase dehydratase
HPY08_18510	ENOG4105JQN	Transcriptional regulator
HPY08_18515	ENOG41069D7	Methyl-accepting chemotaxis
HPY08_18520	ENOG4105EMU	Dehydrogenase
HPY08_18525	ENOG4105JQN	Transcriptional regulator
HPY08_18545	ENOG4105D5Q	Arginine ornithine antiporter
HPY08_18550	ENOG4105CXN	decarboxylase
HPY08_18560	ENOG4105VJY	transcriptional regulator
HPY08_18590	ENOG4107RGH	Aldehyde dehydrogenase
HPY08_18595	ENOG4105EW9	transcriptional regulator AsnC family
HPY08_18600	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_18610	ENOG4105CK7	Sodium proline symporter
HPY08_18620	ENOG4105C26	Dehydrogenase
HPY08_18635	ENOG4105E6M	Sulphatase-modifying factor protein
HPY08_18650	ENOG4107QZV	Type I secretion membrane fusion protein
HPY08_18665	ENOG4108JJA	ABC, transporter
HPY08_18685	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_18690	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY08_18700	ENOG4105BZU	Histidine kinase
HPY08_18705	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY08_18710	ENOG4108V3W	Chemotaxis protein, CheW
HPY08_18715	ENOG4108V3W	Chemotaxis protein, CheW
HPY08_18720	ENOG4105CBS	Chea signal transduction histidine kinase
HPY08_18725	ENOG4108VYJ	response regulator receiver protein
HPY08_18740	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY08_18745	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY08_18750	ENOG4108JQ6	ABC transporter
HPY08_18755	ENOG4105DIJ	Phosphoethanolamine transferase
HPY08_18760	ENOG4105DHQ	Histidine kinase
HPY08_18765	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY08_18795	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HPY08_18800	ENOG4107RUE	extracellular solute-binding protein family 1