locus-tag	class	description
HPY08_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY08_00010	COG0592	DNA-directed DNA polymerase activity
HPY08_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY08_00020	COG0187	DNA topoisomerase II activity
HPY08_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY08_00035	COG3977	Valine--pyruvate aminotransferase
HPY08_00040	COG0751	glycine-tRNA ligase activity
HPY08_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY08_00050	COG2119	membrane
HPY08_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY08_00070	COG0604	alcohol dehydrogenase
HPY08_00080	COG0129	dihydroxy-acid dehydratase activity
HPY08_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY08_00100	COG0606	chelatase, subunit chli
HPY08_00105	COG0204	Acyl-transferase
HPY08_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY08_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY08_00125	COG3084	Protein conserved in bacteria
HPY08_00130	COG4326	sporulation control protein
HPY08_00135	COG1272	protein, Hemolysin III
HPY08_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY08_00150	COG0569	domain protein
HPY08_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY08_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY08_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY08_00165	COG0242	peptide deformylase activity
HPY08_00170	COG1652	LysM domain
HPY08_00175	COG0758	DNA mediated transformation
HPY08_00180	COG2922	Belongs to the Smg family
HPY08_00185	COG0551	DNA topoisomerase type I activity
HPY08_00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY08_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY08_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY08_00205	COG0408	coproporphyrinogen oxidase activity
HPY08_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY08_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY08_00255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY08_00260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY08_00270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY08_00275	COG2104	thiamine diphosphate biosynthetic process
HPY08_00280	COG2022	thiamine diphosphate biosynthetic process
HPY08_00285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY08_00290	COG0006	proline dipeptidase activity
HPY08_00290	COG0006	proline dipeptidase activity
HPY08_00310	COG1522	sequence-specific DNA binding
HPY08_00315	COG5001	Diguanylate cyclase
HPY08_00315	COG5002	protein histidine kinase activity
HPY08_00335	COG0589	response to stress
HPY08_00340	COG1528	Iron-storage protein
HPY08_00350	COG2081	HI0933 family
HPY08_00360	COG1322	Protein conserved in bacteria
HPY08_00365	COG2226	methyltransferase
HPY08_00380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY08_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY08_00390	COG0805	protein transport
HPY08_00395	COG0534	Mate efflux family protein
HPY08_00405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY08_00410	COG2937	Belongs to the GPAT DAPAT family
HPY08_00415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY08_00420	COG3161	chorismate lyase activity
HPY08_00425	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY08_00440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY08_00445	COG0084	hydrolase, TatD family'
HPY08_00460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY08_00460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY08_00480	COG3078	GTPase activator activity
HPY08_00495	COG3071	HemY protein
HPY08_00500	COG2959	enzyme of heme biosynthesis
HPY08_00505	COG1587	Uroporphyrinogen-III synthase
HPY08_00510	COG0181	hydroxymethylbilane synthase activity
HPY08_00520	COG1965	Belongs to the frataxin family
HPY08_00530	COG0019	diaminopimelate decarboxylase activity
HPY08_00535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY08_00545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY08_00550	COG1011	Hydrolase
HPY08_00555	COG2199	diguanylate cyclase activity
HPY08_00555	COG3287	FIST C domain
HPY08_00555	COG2200	EAL domain
HPY08_00570	COG0561	phosphatase activity
HPY08_00575	COG2267	carboxylic ester hydrolase activity
HPY08_00580	COG1280	lysine exporter protein (LysE YggA)
HPY08_00585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY08_00590	COG0783	Belongs to the Dps family
HPY08_00620	COG0742	ribosomal rna small subunit methyltransferase
HPY08_00625	COG0552	protein localization to endoplasmic reticulum
HPY08_00630	COG2884	Cell division ATP-binding protein ftsE
HPY08_00635	COG2177	Part of the ABC transporter FtsEX involved in
HPY08_00640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY08_00645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY08_00660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY08_00670	COG1404	Belongs to the peptidase S8 family
HPY08_00675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY08_00740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY08_00745	COG5001	Diguanylate cyclase
HPY08_00745	COG3300	MHYT domain
HPY08_00755	COG3852	Histidine kinase
HPY08_00765	COG0174	glutamine synthetase
HPY08_00785	COG1295	ribonuclease BN
HPY08_00790	COG1490	D-aminoacyl-tRNA deacylase activity
HPY08_00795	COG0456	acetyltransferase
HPY08_00805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY08_00810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY08_00815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY08_00820	COG3031	protein transport across the cell outer membrane
HPY08_00830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY08_00835	COG1459	type II secretion system
HPY08_00840	COG2165	general secretion pathway protein
HPY08_00845	COG2165	general secretion pathway protein
HPY08_00850	COG2165	general secretion pathway protein
HPY08_00855	COG4795	General secretion pathway protein
HPY08_00860	COG3156	type II secretion system protein K
HPY08_00865	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY08_00870	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY08_00880	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY08_00885	COG0494	nUDIX hydrolase
HPY08_00895	COG1040	competence protein
HPY08_00905	COG0596	Alpha beta hydrolase
HPY08_00915	COG2183	response to ionizing radiation
HPY08_00920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY08_00925	COG2199	diguanylate cyclase activity
HPY08_00930	COG0745	RESPONSE REGULATOR receiver
HPY08_00940	COG2233	PERMEase
HPY08_00945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY08_00950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY08_00955	COG1758	RNA polymerase activity
HPY08_00960	COG0194	GDP metabolic process
HPY08_00965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY08_00970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY08_00980	COG3263	regulation of cellular component size
HPY08_00990	COG4232	protein-disulfide reductase activity
HPY08_01000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY08_01005	COG1027	Aspartate ammonia-lyase
HPY08_01010	COG3706	GGDEF domain
HPY08_01015	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY08_01020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY08_01030	COG2205	protein histidine kinase activity
HPY08_01035	COG0745	RESPONSE REGULATOR receiver
HPY08_01045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY08_01050	COG0205	6-phosphofructokinase activity
HPY08_01055	COG1494	fructose-1,6-bisphosphatase
HPY08_01060	COG3074	FtsZ-dependent cytokinesis
HPY08_01065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY08_01070	COG0527	aspartate kinase activity
HPY08_01070	COG0460	homoserine dehydrogenase
HPY08_01075	COG0626	cystathionine gamma-synthase activity
HPY08_01080	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY08_01085	COG0281	malic enzyme
HPY08_01090	COG0254	rRNA binding
HPY08_01095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY08_01100	COG1609	Transcriptional regulator
HPY08_01105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY08_01110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY08_01115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY08_01120	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY08_01125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY08_01130	COG0534	Mate efflux family protein
HPY08_01135	COG0149	triose-phosphate isomerase activity
HPY08_01160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY08_01165	COG0459	protein refolding
HPY08_01175	COG1509	lysine 2,3-aminomutase activity
HPY08_01180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY08_01190	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY08_01195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY08_01200	COG1053	succinate dehydrogenase
HPY08_01205	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY08_01210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY08_01215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY08_01220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY08_01225	COG1045	serine acetyltransferase
HPY08_01235	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY08_01240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY08_01245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY08_01250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY08_01255	COG0137	argininosuccinate synthase activity
HPY08_01260	COG0165	Argininosuccinate lyase
HPY08_01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY08_01275	COG0678	peroxiredoxin activity
HPY08_01275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY08_01300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY08_01330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY08_01335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY08_01345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY08_01350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY08_01355	COG0546	phosphoglycolate phosphatase activity
HPY08_01360	COG0180	Tryptophanyl-tRNA synthetase
HPY08_01375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY08_01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY08_01395	COG1012	belongs to the aldehyde dehydrogenase family
HPY08_01410	COG3954	Phosphoribulokinase
HPY08_01420	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY08_01430	COG0488	(ABC) transporter
HPY08_01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY08_01450	COG1047	Peptidyl-prolyl cis-trans
HPY08_01460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY08_01465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY08_01470	COG3083	sulfuric ester hydrolase activity
HPY08_01475	COG0557	exoribonuclease II activity
HPY08_01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY08_01485	COG0051	transcription antitermination factor activity, RNA binding
HPY08_01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY08_01495	COG0088	Forms part of the polypeptide exit tunnel
HPY08_01500	COG0089	rRNA binding
HPY08_01505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY08_01510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY08_01515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY08_01520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY08_01525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY08_01530	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY08_01535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY08_01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY08_01545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY08_01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY08_01555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY08_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY08_01565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY08_01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY08_01575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY08_01580	COG1841	ribosomal large subunit assembly
HPY08_01590	COG0201	protein transport
HPY08_01595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY08_01600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY08_01605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY08_01610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY08_01615	COG0202	RNA polymerase activity
HPY08_01620	COG0203	ribosomal protein L17
HPY08_01630	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY08_01635	COG3266	domain, Protein
HPY08_01635	COG3061	Opacity-associated protein A
HPY08_01640	COG0697	spore germination
HPY08_01645	COG2153	protein acetylation
HPY08_01650	COG0513	Belongs to the DEAD box helicase family
HPY08_01660	COG0737	Belongs to the 5'-nucleotidase family
HPY08_01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY08_01665	COG1648	precorrin-2 dehydrogenase activity
HPY08_01670	COG0175	sulfate reduction
HPY08_01675	COG2895	sulfate adenylyltransferase (ATP) activity
HPY08_01680	COG0529	Catalyzes the synthesis of activated sulfate
HPY08_01700	COG1136	(ABC) transporter
HPY08_01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY08_01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY08_01725	COG0729	surface antigen
HPY08_01735	COG2105	PFAM AIG2 family protein
HPY08_01740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY08_01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY08_01755	COG0163	prenyltransferase activity
HPY08_01765	COG1178	ABC-type Fe3 transport system permease component
HPY08_01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY08_01775	COG3028	Belongs to the UPF0307 family
HPY08_01780	COG0312	modulator of DNA gyrase
HPY08_01785	COG2239	Acts as a magnesium transporter
HPY08_01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_01795	COG1660	Displays ATPase and GTPase activities
HPY08_01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY08_01815	COG1137	ATPase activity
HPY08_01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY08_01835	COG0517	IMP dehydrogenase activity
HPY08_01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY08_01845	COG1127	ABC transporter
HPY08_01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY08_01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY08_01860	COG2854	intermembrane phospholipid transfer
HPY08_01870	COG5007	Belongs to the BolA IbaG family
HPY08_01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY08_01885	COG0251	oxidation-reduction process
HPY08_01895	COG0540	Belongs to the ATCase OTCase family
HPY08_01905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY08_01915	COG0564	pseudouridine synthase activity
HPY08_01920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY08_01925	COG4269	membrane
HPY08_01935	COG0525	valine-tRNA ligase activity
HPY08_01940	COG2927	DNA polymerase III (CHI subunit)
HPY08_01945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY08_01950	COG0795	lipopolysaccharide-transporting ATPase activity
HPY08_01955	COG0795	lipopolysaccharide-transporting ATPase activity
HPY08_01970	COG3437	response regulator, receiver
HPY08_02010	COG0066	3-isopropylmalate dehydratase activity
HPY08_02015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY08_02020	COG0473	3-isopropylmalate dehydrogenase activity
HPY08_02040	COG0583	DNA-binding transcription factor activity
HPY08_02045	COG1022	Amp-dependent synthetase and ligase
HPY08_02050	COG0028	Belongs to the TPP enzyme family
HPY08_02055	COG0440	acetolactate synthase activity
HPY08_02060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY08_02065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY08_02070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY08_02080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY08_02085	COG3079	Belongs to the UPF0149 family
HPY08_02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY08_02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY08_02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY08_02120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY08_02125	COG1595	DNA-templated transcription, initiation
HPY08_02130	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HPY08_02135	COG3026	antisigma factor binding
HPY08_02140	COG3086	response to oxidative stress
HPY08_02145	COG0481	GTPase activity
HPY08_02155	COG0571	ribonuclease III activity
HPY08_02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY08_02165	COG1381	Involved in DNA repair and RecF pathway recombination
HPY08_02170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY08_02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY08_02210	COG3956	TIGRFAM MazG family protein
HPY08_02215	COG0504	CTP synthase activity
HPY08_02220	COG0148	phosphopyruvate hydratase activity
HPY08_02225	COG0617	tRNA 3'-terminal CCA addition
HPY08_02230	COG3409	Peptidoglycan-binding domain 1 protein
HPY08_02230	COG3267	Type II secretory pathway component ExeA
HPY08_02240	COG4991	sh3 domain protein
HPY08_02245	COG0306	phosphate transporter
HPY08_02250	COG1392	Phosphate transport regulator
HPY08_02255	COG3025	triphosphatase activity
HPY08_02260	COG0840	transmembrane signaling receptor activity
HPY08_02265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY08_02275	COG1538	Outer membrane efflux protein
HPY08_02280	COG0494	nUDIX hydrolase
HPY08_02285	COG3151	Protein conserved in bacteria
HPY08_02295	COG3150	esterase
HPY08_02300	COG0187	DNA topoisomerase II activity
HPY08_02305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY08_02315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY08_02320	COG0237	dephospho-CoA kinase activity
HPY08_02330	COG1459	type II secretion system
HPY08_02335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY08_02340	COG4969	Belongs to the N-Me-Phe pilin family
HPY08_02345	COG0157	Belongs to the NadC ModD family
HPY08_02355	COG0716	FMN binding
HPY08_02360	COG4974	Belongs to the 'phage' integrase family
HPY08_02365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY08_02370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY08_02375	COG2186	Transcriptional regulator
HPY08_02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY08_02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY08_02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY08_02405	COG3116	cell division
HPY08_02410	COG0768	penicillin binding
HPY08_02415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY08_02420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY08_02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY08_02435	COG0772	Belongs to the SEDS family
HPY08_02440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY08_02445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY08_02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY08_02455	COG0849	cell division
HPY08_02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY08_02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY08_02475	COG0653	protein targeting
HPY08_02480	COG0494	nUDIX hydrolase
HPY08_02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY08_02490	COG0505	Belongs to the CarA family
HPY08_02495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY08_02510	COG0730	response to heat
HPY08_02515	COG0583	DNA-binding transcription factor activity
HPY08_02520	COG2860	membrane
HPY08_02525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY08_02535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY08_02545	COG0493	'glutamate synthase
HPY08_02550	COG0070	glutamate synthase
HPY08_02550	COG0069	glutamate synthase activity
HPY08_02550	COG0067	glutamate synthase
HPY08_02560	COG0070	glutamate synthase
HPY08_02560	COG0067	glutamate synthase
HPY08_02560	COG0069	glutamate synthase activity
HPY08_02565	COG1242	4 iron, 4 sulfur cluster binding
HPY08_02570	COG3706	GGDEF domain
HPY08_02570	COG4251	negative regulation of phosphorylation
HPY08_02570	COG2203	Gaf domain
HPY08_02570	COG5001	Diguanylate cyclase
HPY08_02575	COG0784	Response regulator, receiver
HPY08_02575	COG5002	protein histidine kinase activity
HPY08_02575	COG2198	Histidine kinase
HPY08_02580	COG0745	RESPONSE REGULATOR receiver
HPY08_02590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY08_02610	COG0083	homoserine kinase activity
HPY08_02615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY08_02620	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY08_02625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY08_02630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY08_02645	COG1115	amino acid carrier protein
HPY08_02650	COG3022	response to hydroperoxide
HPY08_02660	COG0084	hydrolase, TatD family'
HPY08_02665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY08_02675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY08_02680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY08_02685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY08_02690	COG0813	purine-nucleoside phosphorylase activity
HPY08_02700	COG0560	Phosphoserine phosphatase
HPY08_02710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY08_02715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY08_02720	COG1022	Amp-dependent synthetase and ligase
HPY08_02735	COG3250	beta-galactosidase activity
HPY08_02740	COG1609	Transcriptional regulator
HPY08_02745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY08_02760	COG0569	domain protein
HPY08_02760	COG0189	ligase activity
HPY08_02765	COG0456	acetyltransferase
HPY08_02775	COG2171	N-acyltransferase activity
HPY08_02780	COG3141	response to X-ray
HPY08_02795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY08_02800	COG1074	ATP-dependent DNA helicase activity
HPY08_02805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY08_02815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY08_02815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY08_02825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY08_02830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY08_02835	COG2166	iron-sulfur cluster assembly
HPY08_02840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY08_02845	COG0693	protein deglycase activity
HPY08_02850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY08_02855	COG3248	Nucleoside-binding outer membrane protein
HPY08_02865	COG1595	DNA-templated transcription, initiation
HPY08_02875	COG2211	Major facilitator Superfamily
HPY08_02880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY08_02890	COG2813	Specifically methylates the guanine in position
HPY08_02895	COG0271	Belongs to the BolA IbaG family
HPY08_02900	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY08_02905	COG1805	sodium ion transport
HPY08_02910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY08_02915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY08_02920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY08_02925	COG2871	sodium ion transport
HPY08_02930	COG1477	protein flavinylation
HPY08_02950	COG3706	GGDEF domain
HPY08_02955	COG0733	neurotransmitter:sodium symporter activity
HPY08_02965	COG0189	ligase activity
HPY08_02970	COG4067	protein conserved in archaea
HPY08_02970	COG0189	ligase activity
HPY08_02975	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY08_02980	COG2252	PERMEase
HPY08_02985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY08_03000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY08_03005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY08_03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY08_03015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY08_03015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY08_03030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY08_03035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY08_03040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY08_03045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY08_03055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY08_03060	COG0024	Methionine aminopeptidase
HPY08_03065	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY08_03070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY08_03075	COG0528	UMP kinase activity
HPY08_03080	COG0233	cytoplasmic translational termination
HPY08_03085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY08_03090	COG0575	Belongs to the CDS family
HPY08_03095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY08_03100	COG0750	zinc metalloprotease
HPY08_03110	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY08_03115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY08_03120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY08_03125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY08_03130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY08_03135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY08_03140	COG0587	DNA-directed DNA polymerase activity
HPY08_03145	COG0825	malonyl-CoA metabolic process
HPY08_03150	COG0037	tRNA processing
HPY08_03160	COG3479	Phenolic acid decarboxylase
HPY08_03165	COG0347	Belongs to the P(II) protein family
HPY08_03170	COG3021	interspecies interaction between organisms
HPY08_03175	COG0741	lytic transglycosylase activity
HPY08_03175	COG1388	LysM domain
HPY08_03180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY08_03185	COG2226	methyltransferase
HPY08_03190	COG0328	RNA-DNA hybrid ribonuclease activity
HPY08_03205	COG1960	acyl-CoA dehydrogenase activity
HPY08_03210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY08_03215	COG0121	glutamine amidotransferase
HPY08_03220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY08_03225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY08_03230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY08_03235	COG3706	GGDEF domain
HPY08_03240	COG1187	pseudouridine synthase activity
HPY08_03245	COG2840	Smr protein MutS2
HPY08_03275	COG2217	Heavy metal translocating P-type atpase
HPY08_03275	COG2608	mercury ion transmembrane transporter activity
HPY08_03280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY08_03295	COG1629	transport
HPY08_03295	COG4774	siderophore transport
HPY08_03300	COG2375	cellular response to nickel ion
HPY08_03305	COG2226	methyltransferase
HPY08_03305	COG3433	isochorismatase activity
HPY08_03305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY08_03340	COG0835	chemotaxis
HPY08_03340	COG0784	Response regulator, receiver
HPY08_03345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY08_03350	COG1815	bacterial-type flagellum-dependent cell motility
HPY08_03365	COG1749	Flagellar hook protein flgE
HPY08_03370	COG4787	bacterial-type flagellum-dependent cell motility
HPY08_03380	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY08_03385	COG1706	bacterial-type flagellum-dependent cell motility
HPY08_03390	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY08_03390	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY08_03405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY08_03410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY08_03495	COG0012	GTP binding
HPY08_03500	COG0193	aminoacyl-tRNA hydrolase activity
HPY08_03505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY08_03510	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY08_03515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY08_03520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY08_03525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY08_03530	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY08_03540	COG2912	Transglutaminase-like superfamily
HPY08_03545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY08_03550	COG0737	Belongs to the 5'-nucleotidase family
HPY08_03555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY08_03560	COG2233	PERMEase
HPY08_03585	COG1393	Belongs to the ArsC family
HPY08_03590	COG4783	chaperone-mediated protein folding
HPY08_03610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY08_03625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY08_03635	COG1876	peptidase activity
HPY08_03645	COG1393	Belongs to the ArsC family
HPY08_03665	COG2837	iron assimilation
HPY08_03670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY08_03675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY08_03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY08_03685	COG1334	flagellar protein FlaG
HPY08_03690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY08_03700	COG1516	flagellar protein fliS
HPY08_03710	COG4191	Histidine kinase
HPY08_03720	COG1677	Flagellar hook-basal body complex protein FliE
HPY08_03730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY08_03760	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY08_03785	COG1987	bacterial-type flagellum assembly
HPY08_03790	COG1684	flagellar biosynthetic protein fliR
HPY08_03800	COG2840	Smr protein MutS2
HPY08_03805	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY08_03810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY08_03815	COG2860	membrane
HPY08_03820	COG3101	peptidyl-lysine hydroxylation
HPY08_03830	COG0431	NADPH-dependent FMN reductase
HPY08_03835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY08_03835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY08_03840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY08_03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY08_03850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY08_03855	COG0735	belongs to the Fur family
HPY08_03865	COG0583	DNA-binding transcription factor activity
HPY08_03875	COG1346	cytolysis
HPY08_03890	COG0596	Alpha beta hydrolase
HPY08_03895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY08_03900	COG0033	Phosphoglucomutase
HPY08_03910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY08_03915	COG0372	Belongs to the citrate synthase family
HPY08_03920	COG2009	succinate dehydrogenase
HPY08_03925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY08_03930	COG1053	succinate dehydrogenase
HPY08_03940	COG0567	Dehydrogenase, E1 component
HPY08_03945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY08_03950	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY08_03960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY08_03965	COG1121	(ABC) transporter
HPY08_03970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY08_03975	COG4977	sequence-specific DNA binding
HPY08_03980	COG1918	ferrous iron import across plasma membrane
HPY08_04000	COG0018	arginyl-trna synthetase
HPY08_04010	COG1025	Belongs to the peptidase M16 family
HPY08_04015	COG2062	phosphohistidine phosphatase, SixA
HPY08_04045	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY08_04050	COG0784	Response regulator, receiver
HPY08_04050	COG0643	Histidine kinase
HPY08_04050	COG2198	Histidine kinase
HPY08_04055	COG2201	protein-glutamate methylesterase activity
HPY08_04060	COG1192	Involved in chromosome partitioning
HPY08_04070	COG0835	chemotaxis
HPY08_04080	COG4133	protoheme IX ABC transporter activity
HPY08_04085	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY08_04090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY08_04100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY08_04105	COG1138	Cytochrome C-type biogenesis protein
HPY08_04110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY08_04125	COG2853	Lipoprotein
HPY08_04145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY08_04150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY08_04155	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY08_04170	COG3083	sulfuric ester hydrolase activity
HPY08_04175	COG3082	Protein of unknown function (DUF1414)
HPY08_04180	COG3081	Nucleoid-associated protein
HPY08_04190	COG1757	Na H antiporter
HPY08_04195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY08_04200	COG2095	MarC family integral membrane protein
HPY08_04205	COG1012	belongs to the aldehyde dehydrogenase family
HPY08_04205	COG1454	alcohol dehydrogenase
HPY08_04215	COG0659	secondary active sulfate transmembrane transporter activity
HPY08_04220	COG1530	ribonuclease E activity
HPY08_04225	COG0564	pseudouridine synthase activity
HPY08_04230	COG0424	maF-like protein
HPY08_04235	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY08_04240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY08_04245	COG0416	fatty acid biosynthetic process
HPY08_04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY08_04260	COG1028	Short-chain dehydrogenase reductase Sdr
HPY08_04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY08_04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY08_04275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY08_04280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY08_04285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY08_04295	COG0084	hydrolase, TatD family'
HPY08_04300	COG1263	PTS System
HPY08_04300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY08_04310	COG0733	neurotransmitter:sodium symporter activity
HPY08_04325	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY08_04335	COG1940	carbohydrate kinase activity
HPY08_04340	COG0835	chemotaxis
HPY08_04340	COG0784	Response regulator, receiver
HPY08_04355	COG2226	methyltransferase
HPY08_04365	COG0676	glucose-6-phosphate 1-epimerase activity
HPY08_04370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY08_04375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY08_04385	COG3139	Protein of unknown function (DUF1315)
HPY08_04390	COG0252	asparaginase activity
HPY08_04395	COG0616	signal peptide processing
HPY08_04400	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY08_04400	COG1902	pentaerythritol trinitrate reductase activity
HPY08_04405	COG0788	formyltetrahydrofolate deformylase activity
HPY08_04415	COG1199	ATP-dependent helicase activity
HPY08_04420	COG1214	PFAM Peptidase M22, glycoprotease
HPY08_04435	COG0596	Alpha beta hydrolase
HPY08_04440	COG0318	PFAM AMP-dependent synthetase and ligase
HPY08_04445	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY08_04460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY08_04465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY08_04470	COG0436	Aminotransferase
HPY08_04475	COG1169	isochorismate synthase
HPY08_04480	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY08_04485	COG0596	Alpha beta hydrolase
HPY08_04505	COG3135	benzoate transporter
HPY08_04530	COG3015	lipoprotein NlpE involved in copper resistance
HPY08_04535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY08_04540	COG2894	cell division
HPY08_04545	COG0850	regulation of cytokinetic process
HPY08_04550	COG3100	YcgL domain-containing protein
HPY08_04555	COG2951	lytic endotransglycosylase activity
HPY08_04565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY08_04570	COG3005	denitrification pathway
HPY08_04575	COG0243	molybdopterin cofactor binding
HPY08_04590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY08_04605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY08_04640	COG4589	Belongs to the CDS family
HPY08_04650	COG3300	MHYT domain
HPY08_04650	COG5001	Diguanylate cyclase
HPY08_04660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY08_04665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY08_04670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY08_04675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY08_04685	COG4191	Histidine kinase
HPY08_04695	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY08_04705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY08_04710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY08_04715	COG0776	regulation of translation
HPY08_04720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY08_04725	COG1555	photosystem II stabilization
HPY08_04730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY08_04735	COG0539	negative regulation of cytoplasmic translation
HPY08_04745	COG0776	regulation of translation
HPY08_04750	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY08_04755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY08_04775	COG0583	DNA-binding transcription factor activity
HPY08_04785	COG0686	Belongs to the AlaDH PNT family
HPY08_04795	COG1674	ftsk spoiiie
HPY08_04800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY08_04805	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY08_04810	COG2186	Transcriptional regulator
HPY08_04825	COG0537	adenosine 5'-monophosphoramidase activity
HPY08_04850	COG3150	esterase
HPY08_04855	COG1252	NADH dehydrogenase
HPY08_04880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY08_04890	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY08_04895	COG1136	(ABC) transporter
HPY08_04900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY08_04910	COG2333	competence protein COMEC
HPY08_04910	COG0658	competence protein
HPY08_04915	COG1132	(ABC) transporter
HPY08_04920	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY08_04925	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY08_04930	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY08_04935	COG2719	SpoVR family
HPY08_04940	COG2718	Belongs to the UPF0229 family
HPY08_04945	COG2766	serine protein kinase
HPY08_04950	COG3013	Belongs to the UPF0304 family
HPY08_04960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY08_04965	COG0840	transmembrane signaling receptor activity
HPY08_04975	COG1882	Formate acetyltransferase
HPY08_05000	COG4160	amino acid transport
HPY08_05005	COG0708	Exodeoxyribonuclease III
HPY08_05015	COG3923	Primosomal replication protein n
HPY08_05020	COG0730	response to heat
HPY08_05025	COG1199	ATP-dependent helicase activity
HPY08_05040	COG3012	SEC-C Motif Domain Protein
HPY08_05045	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY08_05050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY08_05055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY08_05060	COG0215	cysteine-tRNA ligase activity
HPY08_05065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY08_05070	COG0632	four-way junction helicase activity
HPY08_05080	COG1271	oxidase subunit
HPY08_05085	COG1294	oxidase, subunit
HPY08_05090	COG4890	Cyd operon protein YbgT
HPY08_05095	COG3790	cyd operon protein YbgE
HPY08_05100	COG0824	Thioesterase
HPY08_05105	COG0811	peptide transport
HPY08_05120	COG0823	Involved in the tonB-independent uptake of proteins
HPY08_05125	COG2885	chlorophyll binding
HPY08_05135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY08_05145	COG0784	Response regulator, receiver
HPY08_05145	COG5002	protein histidine kinase activity
HPY08_05155	COG1482	cell wall glycoprotein biosynthetic process
HPY08_05160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_05160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY08_05160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY08_05165	COG2207	Transcriptional regulator
HPY08_05175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY08_05180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY08_05185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY08_05195	COG1012	belongs to the aldehyde dehydrogenase family
HPY08_05200	COG3284	Transcriptional regulator
HPY08_05205	COG4628	conserved protein (DUF2132)
HPY08_05215	COG0415	Belongs to the DNA photolyase family
HPY08_05250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY08_05260	COG3008	intermembrane lipid transfer
HPY08_05260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY08_05265	COG2995	paraquat-inducible protein a
HPY08_05270	COG0668	transmembrane transport
HPY08_05290	COG1309	transcriptional regulator
HPY08_05295	COG1012	belongs to the aldehyde dehydrogenase family
HPY08_05315	COG1960	acyl-CoA dehydrogenase activity
HPY08_05320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY08_05325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY08_05335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY08_05350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY08_05355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY08_05360	COG0297	glycogen (starch) synthase activity
HPY08_05380	COG3070	regulator of competence-specific genes
HPY08_05385	COG1609	Transcriptional regulator
HPY08_05390	COG3381	protein complex oligomerization
HPY08_05395	COG0745	RESPONSE REGULATOR receiver
HPY08_05400	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY08_05405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY08_05410	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY08_05415	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY08_05430	COG1280	lysine exporter protein (LysE YggA)
HPY08_05435	COG1032	radical SAM domain protein
HPY08_05440	COG5001	Diguanylate cyclase
HPY08_05445	COG0612	Peptidase, M16
HPY08_05460	COG0583	DNA-binding transcription factor activity
HPY08_05465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY08_05475	COG2350	Protein conserved in bacteria
HPY08_05480	COG1607	acyl-coa hydrolase
HPY08_05495	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY08_05500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY08_05510	COG2116	formate transmembrane transporter activity
HPY08_05515	COG4459	periplasmic nitrate reductase
HPY08_05520	COG3005	denitrification pathway
HPY08_05525	COG0243	molybdopterin cofactor binding
HPY08_05540	COG1227	inorganic diphosphatase activity
HPY08_05555	COG4172	Belongs to the ABC transporter superfamily
HPY08_05570	COG4168	peptide transport system, permease
HPY08_05580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY08_05585	COG1842	Phage shock protein A
HPY08_05600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY08_05615	COG2818	Glycosylase
HPY08_05620	COG0626	cystathionine gamma-synthase activity
HPY08_05630	COG0733	neurotransmitter:sodium symporter activity
HPY08_05635	COG0564	pseudouridine synthase activity
HPY08_05640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY08_05645	COG4136	ATPase activity
HPY08_05650	COG4135	transport system, permease component
HPY08_05655	COG4134	Bacterial extracellular solute-binding protein
HPY08_05665	COG3313	Fe-S protein
HPY08_05675	COG0814	amino acid
HPY08_05685	COG2239	Acts as a magnesium transporter
HPY08_05690	COG2205	protein histidine kinase activity
HPY08_05690	COG0784	Response regulator, receiver
HPY08_05705	COG4934	collagen metabolic process
HPY08_05740	COG0840	transmembrane signaling receptor activity
HPY08_05750	COG2203	Gaf domain
HPY08_05750	COG3706	GGDEF domain
HPY08_05750	COG4251	negative regulation of phosphorylation
HPY08_05750	COG5001	Diguanylate cyclase
HPY08_05755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY08_05775	COG1061	Type III restriction enzyme res subunit
HPY08_05780	COG1187	pseudouridine synthase activity
HPY08_05785	COG2814	Major facilitator Superfamily
HPY08_05795	COG0702	epimerase
HPY08_05800	COG0534	Mate efflux family protein
HPY08_05805	COG4181	ATPase activity
HPY08_05820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY08_05830	COG1748	Saccharopine dehydrogenase
HPY08_05845	COG1538	Outer membrane efflux protein
HPY08_05885	COG1451	nucleotide metabolic process
HPY08_05925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY08_05940	COG3290	protein histidine kinase activity
HPY08_05945	COG4565	transcriptional regulatory protein
HPY08_05955	COG0784	Response regulator, receiver
HPY08_05955	COG0835	chemotaxis
HPY08_06005	COG1085	galactose-1-phosphate uridylyltransferase
HPY08_06010	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY08_06015	COG2017	converts alpha-aldose to the beta-anomer
HPY08_06030	COG3527	Alpha-acetolactate decarboxylase
HPY08_06045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY08_06095	COG1271	oxidase subunit
HPY08_06100	COG1294	oxidase, subunit
HPY08_06105	COG0577	efflux transmembrane transporter activity
HPY08_06105	COG1136	(ABC) transporter
HPY08_06110	COG1136	(ABC) transporter
HPY08_06110	COG0577	efflux transmembrane transporter activity
HPY08_06115	COG0577	efflux transmembrane transporter activity
HPY08_06115	COG1136	(ABC) transporter
HPY08_06145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY08_06160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY08_06170	COG2723	6-phospho-beta-galactosidase activity
HPY08_06175	COG1609	Transcriptional regulator
HPY08_06180	COG0251	oxidation-reduction process
HPY08_06185	COG2731	YhcH YjgK YiaL family protein
HPY08_06190	COG0584	glycerophosphoryl diester phosphodiesterase
HPY08_06195	COG1349	DNA-binding transcription factor activity
HPY08_06200	COG3842	ATPase activity
HPY08_06205	COG0395	ABC-type sugar transport system, permease component
HPY08_06210	COG1175	transmembrane transport
HPY08_06225	COG0811	peptide transport
HPY08_06230	COG0811	peptide transport
HPY08_06235	COG0848	biopolymer transport protein
HPY08_06240	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY08_06250	COG1793	dna ligase
HPY08_06260	COG0534	Mate efflux family protein
HPY08_06270	COG3001	Fructosamine kinase
HPY08_06280	COG0791	NLP P60 protein
HPY08_06285	COG0840	transmembrane signaling receptor activity
HPY08_06300	COG1940	carbohydrate kinase activity
HPY08_06320	COG0746	molybdenum cofactor guanylyltransferase activity
HPY08_06325	COG3842	ATPase activity
HPY08_06330	COG4662	Binding-protein-dependent transport system inner membrane component
HPY08_06340	COG2204	response regulator
HPY08_06345	COG3852	Histidine kinase
HPY08_06350	COG0488	(ABC) transporter
HPY08_06355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY08_06385	COG3383	formate dehydrogenase (NAD+) activity
HPY08_06385	COG0243	molybdopterin cofactor binding
HPY08_06390	COG0437	4 iron, 4 sulfur cluster binding
HPY08_06405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY08_06410	COG1666	GTP binding
HPY08_06415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY08_06430	COG2996	Protein conserved in bacteria
HPY08_06440	COG3008	intermembrane lipid transfer
HPY08_06445	COG2995	paraquat-inducible protein a
HPY08_06450	COG1132	(ABC) transporter
HPY08_06455	COG1956	GAF domain-containing protein
HPY08_06460	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY08_06475	COG0308	aminopeptidase N
HPY08_06490	COG0167	dihydroorotate dehydrogenase activity
HPY08_06500	COG0116	Belongs to the methyltransferase superfamily
HPY08_06500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY08_06525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY08_06530	COG1067	ATP-dependent peptidase activity
HPY08_06535	COG3120	sequence-specific DNA binding
HPY08_06610	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY08_06610	COG1073	alpha beta
HPY08_06610	COG3064	Membrane
HPY08_06615	COG2994	toxin metabolic process
HPY08_06640	COG2205	protein histidine kinase activity
HPY08_06640	COG0784	Response regulator, receiver
HPY08_06655	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY08_06670	COG2010	Cytochrome c
HPY08_06680	COG2217	Heavy metal translocating P-type atpase
HPY08_06695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY08_06700	COG0589	response to stress
HPY08_06715	COG0037	tRNA processing
HPY08_06735	COG3842	ATPase activity
HPY08_06745	COG1177	transmembrane transport
HPY08_06755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY08_06770	COG1115	amino acid carrier protein
HPY08_06775	COG1280	lysine exporter protein (LysE YggA)
HPY08_06805	COG3501	Rhs element vgr protein
HPY08_06815	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY08_06835	COG0513	Belongs to the DEAD box helicase family
HPY08_06840	COG2076	Multidrug Resistance protein
HPY08_06845	COG0415	Belongs to the DNA photolyase family
HPY08_06850	COG0477	Major facilitator Superfamily
HPY08_06855	COG0583	DNA-binding transcription factor activity
HPY08_06865	COG0402	S-adenosylhomocysteine deaminase activity
HPY08_06870	COG0095	Lipoate-protein ligase
HPY08_06875	COG0443	Heat shock 70 kDa protein
HPY08_06885	COG1643	Atp-dependent helicase
HPY08_06920	COG0443	Heat shock 70 kDa protein
HPY08_06925	COG3706	GGDEF domain
HPY08_06955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY08_06960	COG0602	queuosine metabolic process
HPY08_06965	COG0561	phosphatase activity
HPY08_06975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY08_06980	COG4597	amino acid ABC transporter
HPY08_06985	COG0765	amino acid transport
HPY08_06990	COG1126	abc transporter atp-binding protein
HPY08_06995	COG0670	Belongs to the BI1 family
HPY08_07000	COG2920	part of a sulfur-relay system
HPY08_07005	COG1254	Belongs to the acylphosphatase family
HPY08_07010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY08_07015	COG2801	Transposase and inactivated derivatives
HPY08_07020	COG3706	GGDEF domain
HPY08_07030	COG2205	protein histidine kinase activity
HPY08_07030	COG3437	response regulator, receiver
HPY08_07030	COG3850	Histidine kinase
HPY08_07030	COG4999	Histidine kinase
HPY08_07035	COG3437	response regulator, receiver
HPY08_07040	COG0625	glutathione transferase activity
HPY08_07050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY08_07060	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY08_07090	COG0372	Belongs to the citrate synthase family
HPY08_07095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY08_07130	COG0583	DNA-binding transcription factor activity
HPY08_07135	COG4771	TonB-dependent receptor
HPY08_07160	COG1566	PFAM secretion protein HlyD family protein
HPY08_07180	COG1129	ABC transporter
HPY08_07205	COG0745	RESPONSE REGULATOR receiver
HPY08_07210	COG5002	protein histidine kinase activity
HPY08_07215	COG3713	MltA-interacting MipA family protein
HPY08_07220	COG2990	Protein conserved in bacteria
HPY08_07230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY08_07230	COG4191	Histidine kinase
HPY08_07235	COG0471	metal ion transport
HPY08_07245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY08_07260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY08_07270	COG3768	UPF0283 membrane protein
HPY08_07275	COG3106	COG3106 Predicted ATPase
HPY08_07290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY08_07295	COG0494	nUDIX hydrolase
HPY08_07300	COG0814	amino acid
HPY08_07305	COG1760	l-serine dehydratase
HPY08_07310	COG0720	synthase
HPY08_07315	COG0840	transmembrane signaling receptor activity
HPY08_07320	COG0017	Asparaginyl-tRNA synthetase
HPY08_07325	COG0352	thiamine-phosphate diphosphorylase activity
HPY08_07325	COG0351	phosphomethylpyrimidine kinase
HPY08_07330	COG3437	response regulator, receiver
HPY08_07330	COG2770	Histidine kinase
HPY08_07335	COG1448	Aminotransferase
HPY08_07345	COG2176	DNA-directed DNA polymerase activity
HPY08_07350	COG0840	transmembrane signaling receptor activity
HPY08_07355	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY08_07360	COG2943	transferase activity, transferring hexosyl groups
HPY08_07365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY08_07370	COG1846	Transcriptional regulator
HPY08_07395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY08_07410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY08_07415	COG3108	Peptidase M15
HPY08_07445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY08_07455	COG2814	Major facilitator Superfamily
HPY08_07475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY08_07480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY08_07485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY08_07515	COG0840	transmembrane signaling receptor activity
HPY08_07530	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY08_07535	COG4139	cobalamin transport
HPY08_07540	COG2988	succinylglutamate desuccinylase activity
HPY08_07555	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY08_07560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY08_07565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY08_07575	COG2925	Exonuclease
HPY08_07580	COG1380	Effector of murein hydrolase LrgA
HPY08_07585	COG1346	cytolysis
HPY08_07615	COG0776	regulation of translation
HPY08_07620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY08_07620	COG0072	phenylalanine-tRNA ligase activity
HPY08_07625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY08_07665	COG0322	excinuclease ABC activity
HPY08_07670	COG2197	response regulator
HPY08_07675	COG0417	DNA replication proofreading
HPY08_07680	COG5001	Diguanylate cyclase
HPY08_07690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY08_07695	COG3099	Belongs to the UPF0263 family
HPY08_07710	COG1228	amidohydrolase
HPY08_07715	COG0010	Belongs to the arginase family
HPY08_07720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY08_07725	COG2986	histidine ammonia-lyase
HPY08_07745	COG0277	FAD linked oxidase domain protein
HPY08_07745	COG0247	lactate metabolic process
HPY08_07760	COG2885	chlorophyll binding
HPY08_07780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY08_07790	COG0281	malic enzyme
HPY08_07800	COG2949	membrane
HPY08_07805	COG3706	GGDEF domain
HPY08_07810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY08_07820	COG0492	ferredoxin-NADP+ reductase activity
HPY08_07825	COG4988	ABC transporter
HPY08_07830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY08_07835	COG1187	pseudouridine synthase activity
HPY08_07840	COG0009	L-threonylcarbamoyladenylate synthase
HPY08_07845	COG0613	PHP domain protein
HPY08_07855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY08_07860	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY08_07865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY08_07870	COG0135	phosphoribosylanthranilate isomerase activity
HPY08_07870	COG0134	indole-3-glycerol-phosphate synthase activity
HPY08_07875	COG0133	tryptophan synthase activity
HPY08_07880	COG0159	tryptophan synthase activity
HPY08_07890	COG1435	thymidine kinase activity
HPY08_07895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY08_07900	COG1801	Protein of unknown function DUF72
HPY08_07905	COG4106	trans-aconitate 2-methyltransferase activity
HPY08_07910	COG0500	methyltransferase
HPY08_07915	COG4067	protein conserved in archaea
HPY08_07915	COG0189	ligase activity
HPY08_07930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY08_07940	COG3852	Histidine kinase
HPY08_07955	COG3070	regulator of competence-specific genes
HPY08_07965	COG2431	L-lysine efflux transmembrane transporter activity
HPY08_07975	COG0076	glutamate decarboxylase activity
HPY08_07980	COG1737	Transcriptional regulator
HPY08_07985	COG1454	alcohol dehydrogenase
HPY08_07985	COG1012	belongs to the aldehyde dehydrogenase family
HPY08_07990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY08_07995	COG2985	domain, Protein
HPY08_07995	COG3273	potassium ion transport
HPY08_08000	COG0542	response to heat
HPY08_08005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY08_08010	COG1278	Cold shock
HPY08_08020	COG1187	pseudouridine synthase activity
HPY08_08025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY08_08025	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY08_08030	COG0107	imidazoleglycerol-phosphate synthase activity
HPY08_08035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY08_08040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY08_08045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY08_08045	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY08_08050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY08_08055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY08_08060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY08_08065	COG1757	Na H antiporter
HPY08_08070	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY08_08075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY08_08080	COG0482	sulfurtransferase activity
HPY08_08085	COG2915	High frequency lysogenization protein hflD homolog
HPY08_08090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY08_08100	COG2268	Band 7 protein
HPY08_08110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY08_08125	COG0300	oxidoreductase activity
HPY08_08135	COG0501	Belongs to the peptidase M48B family
HPY08_08145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY08_08150	COG2226	methyltransferase
HPY08_08155	COG0156	8-amino-7-oxononanoate synthase activity
HPY08_08160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY08_08165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY08_08170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY08_08175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY08_08180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY08_08185	COG0653	protein targeting
HPY08_08190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY08_08195	COG2199	diguanylate cyclase activity
HPY08_08195	COG2203	Gaf domain
HPY08_08205	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY08_08215	COG4628	conserved protein (DUF2132)
HPY08_08220	COG3092	negative regulation of chromosome organization
HPY08_08225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY08_08230	COG0857	belongs to the CobB CobQ family
HPY08_08230	COG0280	phosphate acetyltransferase
HPY08_08235	COG0435	Glutathione S-transferase
HPY08_08240	COG4608	Belongs to the ABC transporter superfamily
HPY08_08245	COG0444	Belongs to the ABC transporter superfamily
HPY08_08250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY08_08255	COG0601	transmembrane transport
HPY08_08275	COG2204	response regulator
HPY08_08280	COG3300	MHYT domain
HPY08_08280	COG5001	Diguanylate cyclase
HPY08_08285	COG4191	Histidine kinase
HPY08_08290	COG5002	protein histidine kinase activity
HPY08_08300	COG2201	protein-glutamate methylesterase activity
HPY08_08315	COG0009	L-threonylcarbamoyladenylate synthase
HPY08_08330	COG1881	PFAM PEBP family protein
HPY08_08355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY08_08360	COG0640	Transcriptional regulator
HPY08_08475	COG3706	GGDEF domain
HPY08_08495	COG1946	Acyl-CoA thioesterase
HPY08_08500	COG1522	sequence-specific DNA binding
HPY08_08510	COG0616	signal peptide processing
HPY08_08515	COG1028	Short-chain dehydrogenase reductase Sdr
HPY08_08520	COG2983	Belongs to the UPF0260 family
HPY08_08530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY08_08535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY08_08540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY08_08545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY08_08550	COG2832	Protein of unknown function (DUF454)
HPY08_08555	COG0745	RESPONSE REGULATOR receiver
HPY08_08560	COG0583	DNA-binding transcription factor activity
HPY08_08565	COG0778	Nitroreductase
HPY08_08570	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY08_08570	COG1024	Enoyl-CoA hydratase
HPY08_08575	COG0183	Belongs to the thiolase family
HPY08_08590	COG2067	long-chain fatty acid transport protein
HPY08_08595	COG2067	long-chain fatty acid transport protein
HPY08_08600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY08_08605	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY08_08610	COG2982	Protein involved in outer membrane biogenesis
HPY08_08615	COG0572	uridine kinase
HPY08_08620	COG0489	protein tyrosine kinase activity
HPY08_08625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY08_08625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY08_08635	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY08_08645	COG0517	IMP dehydrogenase activity
HPY08_08645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY08_08645	COG0617	tRNA 3'-terminal CCA addition
HPY08_08650	COG2199	diguanylate cyclase activity
HPY08_08655	COG0314	molybdopterin synthase activity
HPY08_08660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY08_08665	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY08_08670	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY08_08675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY08_08680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY08_08685	COG2198	Histidine kinase
HPY08_08690	COG2204	response regulator
HPY08_08695	COG0556	nucleotide-excision repair
HPY08_08705	COG4657	Part of a membrane complex involved in electron transport
HPY08_08710	COG2878	Part of a membrane complex involved in electron transport
HPY08_08715	COG4656	Part of a membrane complex involved in electron transport
HPY08_08730	COG4660	Part of a membrane complex involved in electron transport
HPY08_08735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY08_08740	COG0346	lactoylglutathione lyase activity
HPY08_08755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY08_08760	COG2056	Na+-H+ antiporter family
HPY08_08765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY08_08770	COG1286	toxin biosynthetic process
HPY08_08775	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY08_08780	COG0285	dihydrofolate synthase activity
HPY08_08785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY08_08790	COG0101	tRNA pseudouridine synthase activity
HPY08_08805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY08_08805	COG1263	PTS System
HPY08_08805	COG2190	(PTS) system
HPY08_08810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY08_08815	COG1846	Transcriptional regulator
HPY08_08815	COG1940	carbohydrate kinase activity
HPY08_08820	COG4651	solute:proton antiporter activity
HPY08_08820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY08_08825	COG0367	asparagine synthase
HPY08_08840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY08_08845	COG0563	adenylate kinase activity
HPY08_08850	COG0326	Molecular chaperone. Has ATPase activity
HPY08_08855	COG3710	Transcriptional regulator
HPY08_08870	COG0622	Phosphoesterase
HPY08_08875	COG1090	epimerase
HPY08_08880	COG0300	oxidoreductase activity
HPY08_08885	COG3118	belongs to the thioredoxin family
HPY08_08890	COG0330	HflC and HflK could
HPY08_08895	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY08_08900	COG0789	Transcriptional regulator
HPY08_08915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY08_08920	COG3115	cell septum assembly
HPY08_08925	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY08_08930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY08_08935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_08945	COG2190	(PTS) system
HPY08_08950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY08_08955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY08_08960	COG1702	phosphate starvation-inducible protein PhoH
HPY08_08970	COG4535	Mg2 and Co2 transporter CorC
HPY08_08975	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY08_08980	COG2888	peptidyl-tyrosine sulfation
HPY08_08985	COG0495	leucyl-tRNA aminoacylation
HPY08_08990	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY08_08995	COG1466	dna polymerase III delta subunit
HPY08_09000	COG0799	negative regulation of ribosome biogenesis
HPY08_09005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY08_09010	COG0768	penicillin binding
HPY08_09015	COG0772	Belongs to the SEDS family
HPY08_09020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY08_09025	COG1686	Belongs to the peptidase S11 family
HPY08_09030	COG2921	Belongs to the UPF0250 family
HPY08_09035	COG0321	lipoyl(octanoyl) transferase activity
HPY08_09040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY08_09050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY08_09075	COG1596	polysaccharide export
HPY08_09085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY08_09115	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY08_09125	COG0438	transferase activity, transferring glycosyl groups
HPY08_09135	COG1045	serine acetyltransferase
HPY08_09155	COG0110	maltose O-acetyltransferase activity
HPY08_09160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY08_09165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY08_09170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY08_09175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY08_09205	COG0366	Alpha amylase catalytic
HPY08_09210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY08_09210	COG1263	PTS System
HPY08_09215	COG1609	Transcriptional regulator
HPY08_09220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY08_09225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY08_09230	COG2011	ABC-type metal ion transport system permease component
HPY08_09235	COG1464	Belongs to the NlpA lipoprotein family
HPY08_09240	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY08_09250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY08_09250	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY08_09260	COG3706	GGDEF domain
HPY08_09265	COG1611	Belongs to the LOG family
HPY08_09270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY08_09275	COG2363	Small membrane protein
HPY08_09280	COG0583	DNA-binding transcription factor activity
HPY08_09285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY08_09285	COG0301	tRNA thio-modification
HPY08_09295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY08_09300	COG1722	exodeoxyribonuclease VII activity
HPY08_09305	COG0142	geranyltranstransferase activity
HPY08_09310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY08_09315	COG0564	pseudouridine synthase activity
HPY08_09320	COG3098	single-species biofilm formation
HPY08_09335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY08_09345	COG1671	Belongs to the UPF0178 family
HPY08_09350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY08_09355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY08_09360	COG0254	rRNA binding
HPY08_09365	COG1720	tRNA m6t6A37 methyltransferase activity
HPY08_09370	COG0442	prolyl-tRNA aminoacylation
HPY08_09390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY08_09390	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY08_09400	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY08_09410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY08_09440	COG0484	heat shock protein binding
HPY08_09445	COG0443	Heat shock 70 kDa protein
HPY08_09450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY08_09455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY08_09460	COG0497	DNA recombination
HPY08_09465	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY08_09470	COG2914	Belongs to the UPF0125 (RnfH) family
HPY08_09475	COG2867	negative regulation of translational initiation
HPY08_09480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY08_09510	COG0514	ATP-dependent DNA helicase (RecQ)
HPY08_09530	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY08_09535	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY08_09540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY08_09560	COG3051	citrate lyase alpha subunit
HPY08_09565	COG2301	Belongs to the HpcH HpaI aldolase family
HPY08_09575	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY08_09585	COG3630	sodium ion export across plasma membrane
HPY08_09590	COG0511	ligase activity, forming carbon-carbon bonds
HPY08_09590	COG5016	pyruvate
HPY08_09595	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY08_09605	COG4565	transcriptional regulatory protein
HPY08_09630	COG1115	amino acid carrier protein
HPY08_09635	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY08_09640	COG0583	DNA-binding transcription factor activity
HPY08_09650	COG1120	ATPase activity
HPY08_09655	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY08_09660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY08_09665	COG4592	Periplasmic binding protein
HPY08_09675	COG1028	Short-chain dehydrogenase reductase Sdr
HPY08_09680	COG1169	isochorismate synthase
HPY08_09685	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY08_09690	COG1535	isochorismatase
HPY08_09690	COG3433	isochorismatase activity
HPY08_09695	COG1584	GPR1 FUN34 yaaH family protein
HPY08_09705	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY08_09715	COG0519	Catalyzes the synthesis of GMP from XMP
HPY08_09715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY08_09720	COG0516	GMP reductase activity
HPY08_09720	COG0517	IMP dehydrogenase activity
HPY08_09725	COG1570	exodeoxyribonuclease VII activity
HPY08_09740	COG1160	GTP binding
HPY08_09745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY08_09750	COG2976	Protein conserved in bacteria
HPY08_09755	COG0124	histidyl-tRNA synthetase
HPY08_09760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY08_09770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPY08_09775	COG0105	UTP biosynthetic process
HPY08_09780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY08_09785	COG2975	iron-sulfur cluster assembly
HPY08_09790	COG0633	Ferredoxin
HPY08_09810	COG0822	iron-sulfur transferase activity
HPY08_09820	COG1959	2 iron, 2 sulfur cluster binding
HPY08_09830	COG0483	inositol monophosphate 1-phosphatase activity
HPY08_09835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY08_09840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY08_09845	COG1862	Preprotein translocase
HPY08_09855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY08_09860	COG0517	IMP dehydrogenase activity
HPY08_09870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY08_09875	COG0583	DNA-binding transcription factor activity
HPY08_09880	COG0450	alkyl hydroperoxide reductase
HPY08_09885	COG3142	Participates in the control of copper homeostasis
HPY08_09900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY08_09905	COG0581	inorganic phosphate transmembrane transporter activity
HPY08_09915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY08_09920	COG0248	Ppx GppA phosphatase
HPY08_09930	COG5002	protein histidine kinase activity
HPY08_09935	COG0745	RESPONSE REGULATOR receiver
HPY08_09950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY08_09995	COG0542	response to heat
HPY08_10005	COG0564	pseudouridine synthase activity
HPY08_10010	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY08_10015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY08_10020	COG1605	Chorismate mutase
HPY08_10020	COG0077	Prephenate dehydratase
HPY08_10025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY08_10030	COG5001	Diguanylate cyclase
HPY08_10040	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY08_10050	COG0488	(ABC) transporter
HPY08_10060	COG0287	Prephenate dehydrogenase
HPY08_10060	COG1605	Chorismate mutase
HPY08_10065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY08_10070	COG3275	phosphorelay sensor kinase activity
HPY08_10075	COG3279	Response regulator of the LytR AlgR family
HPY08_10085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY08_10090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY08_10105	COG1966	Carbon starvation protein
HPY08_10110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY08_10115	COG1047	Peptidyl-prolyl cis-trans
HPY08_10120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY08_10130	COG0196	riboflavin kinase activity
HPY08_10135	COG0728	peptidoglycan biosynthetic process
HPY08_10140	COG0268	Binds directly to 16S ribosomal RNA
HPY08_10145	COG0640	Transcriptional regulator
HPY08_10150	COG0583	DNA-binding transcription factor activity
HPY08_10155	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY08_10160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPY08_10165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY08_10170	COG0730	response to heat
HPY08_10175	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY08_10180	COG0494	nUDIX hydrolase
HPY08_10185	COG3066	DNA modification
HPY08_10190	COG0667	Aldo Keto reductase
HPY08_10200	COG2204	response regulator
HPY08_10205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY08_10225	COG0513	Belongs to the DEAD box helicase family
HPY08_10250	COG3153	acetyltransferase
HPY08_10255	COG3154	lipid carrier protein
HPY08_10265	COG0826	peptidase U32
HPY08_10270	COG0826	peptidase U32
HPY08_10295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY08_10305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY08_10310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY08_10315	COG0195	Participates in both transcription termination and antitermination
HPY08_10320	COG0779	Required for maturation of 30S ribosomal subunits
HPY08_10335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY08_10345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY08_10350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY08_10355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY08_10360	COG1534	Rna-binding protein
HPY08_10365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY08_10370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY08_10375	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY08_10380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY08_10385	COG0739	heme binding
HPY08_10400	COG0316	Belongs to the HesB IscA family
HPY08_10405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY08_10410	COG0628	permease
HPY08_10415	COG2813	Specifically methylates the guanine in position
HPY08_10420	COG2205	protein histidine kinase activity
HPY08_10420	COG0784	Response regulator, receiver
HPY08_10425	COG0747	negative chemotaxis
HPY08_10435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY08_10440	COG0444	Belongs to the ABC transporter superfamily
HPY08_10445	COG4608	Belongs to the ABC transporter superfamily
HPY08_10455	COG2971	BadF BadG BcrA BcrD
HPY08_10475	COG3842	ATPase activity
HPY08_10485	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY08_10490	COG0004	ammonium transporteR
HPY08_10495	COG0347	Belongs to the P(II) protein family
HPY08_10500	COG3112	Uncharacterised protein family (UPF0231)
HPY08_10505	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY08_10510	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY08_10515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY08_10520	COG1643	Atp-dependent helicase
HPY08_10530	COG1489	DNA binding
HPY08_10540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY08_10550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY08_10555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY08_10560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY08_10565	COG0842	Transport permease protein
HPY08_10570	COG1131	(ABC) transporter
HPY08_10575	COG0659	secondary active sulfate transmembrane transporter activity
HPY08_10580	COG0288	reversible hydration of carbon dioxide
HPY08_10595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY08_10600	COG3107	peptidoglycan biosynthetic process
HPY08_10605	COG0792	nuclease activity
HPY08_10610	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY08_10615	COG2823	Periplasmic or secreted lipoprotein
HPY08_10620	COG2969	positive regulation of protein catabolic process
HPY08_10625	COG0625	glutathione transferase activity
HPY08_10630	COG2857	Cytochrome c1
HPY08_10635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY08_10640	COG0723	plastoquinol--plastocyanin reductase activity
HPY08_10645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY08_10650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY08_10655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY08_10665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY08_10670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY08_10675	COG0335	large ribosomal subunit rRNA binding
HPY08_10680	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY08_10685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY08_10690	COG0228	four-way junction DNA binding
HPY08_10695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY08_10700	COG4137	Cytochrome C assembly protein
HPY08_10705	COG4536	flavin adenine dinucleotide binding
HPY08_10710	COG1854	S-ribosylhomocysteine lyase activity
HPY08_10715	COG2918	glutathione biosynthetic process
HPY08_10720	COG0612	Peptidase, M16
HPY08_10725	COG1238	metal cluster binding
HPY08_10735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY08_10740	COG0511	ligase activity, forming carbon-carbon bonds
HPY08_10740	COG5016	pyruvate
HPY08_10745	COG3630	sodium ion export across plasma membrane
HPY08_10790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY08_10795	COG0527	aspartate kinase activity
HPY08_10800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY08_10810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY08_10820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY08_10825	COG4208	sulfate ABC transporter
HPY08_10845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY08_10850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY08_10860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY08_10865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY08_10870	COG0585	pseudouridine synthase activity
HPY08_10875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY08_10880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY08_10885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY08_10890	COG1968	undecaprenyl-diphosphatase activity
HPY08_10895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY08_10900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY08_10905	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY08_10915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY08_10920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY08_10925	COG1610	YqeY-like protein
HPY08_10930	COG0358	DNA primase activity
HPY08_10950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY08_10955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY08_10960	COG1349	DNA-binding transcription factor activity
HPY08_10980	COG1279	arginine transmembrane transporter activity
HPY08_10985	COG0668	transmembrane transport
HPY08_10990	COG0191	fructose-bisphosphate aldolase activity
HPY08_10995	COG0126	phosphoglycerate kinase activity
HPY08_11000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY08_11005	COG4771	TonB-dependent receptor
HPY08_11010	COG0583	DNA-binding transcription factor activity
HPY08_11015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY08_11020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY08_11025	COG3091	SprT-like family
HPY08_11030	COG2356	endonuclease I
HPY08_11035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY08_11040	COG0189	ligase activity
HPY08_11045	COG1678	Uncharacterized ACR, COG1678
HPY08_11050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY08_11055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY08_11075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY08_11080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY08_11085	COG0762	integral membrane protein
HPY08_11100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY08_11105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY08_11110	COG2066	Belongs to the glutaminase family
HPY08_11115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY08_11120	COG1194	a g-specific adenine glycosylase
HPY08_11125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY08_11130	COG0741	lytic transglycosylase activity
HPY08_11185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY08_11190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY08_11195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY08_11200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY08_11205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY08_11210	COG2967	ApaG domain
HPY08_11215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY08_11225	COG3610	response to peptide
HPY08_11230	COG2966	Psort location CytoplasmicMembrane, score
HPY08_11235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY08_11240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY08_11245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY08_11250	COG0142	geranyltranstransferase activity
HPY08_11255	COG0531	amino acid
HPY08_11260	COG0039	L-malate dehydrogenase activity
HPY08_11265	COG1438	arginine binding
HPY08_11270	COG2358	TRAP transporter, solute receptor (TAXI family
HPY08_11280	COG0589	response to stress
HPY08_11300	COG2235	arginine
HPY08_11305	COG0312	modulator of DNA gyrase
HPY08_11310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY08_11315	COG3164	Protein of unknown function
HPY08_11320	COG1530	ribonuclease E activity
HPY08_11325	COG0424	maF-like protein
HPY08_11330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY08_11335	COG1792	Involved in formation and maintenance of cell shape
HPY08_11340	COG1077	Cell shape determining protein MreB Mrl
HPY08_11385	COG1459	type II secretion system
HPY08_11390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY08_11400	COG3267	Type II secretory pathway component ExeA
HPY08_11400	COG3409	Peptidoglycan-binding domain 1 protein
HPY08_11425	COG2199	diguanylate cyclase activity
HPY08_11425	COG2200	EAL domain
HPY08_11430	COG0629	single-stranded DNA binding
HPY08_11445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY08_11455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY08_11460	COG0527	aspartate kinase activity
HPY08_11465	COG1410	methionine synthase
HPY08_11465	COG0646	methionine synthase
HPY08_11540	COG0175	sulfate reduction
HPY08_11550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY08_11575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY08_11580	COG0735	belongs to the Fur family
HPY08_11595	COG0166	Belongs to the GPI family
HPY08_11600	COG0432	Pfam Uncharacterised protein family UPF0047
HPY08_11605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY08_11620	COG0359	binds to the 23S rRNA
HPY08_11625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY08_11630	COG2965	DNA replication, synthesis of RNA primer
HPY08_11635	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY08_11645	COG2906	2 iron, 2 sulfur cluster binding
HPY08_11650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY08_11655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY08_11660	COG0049	tRNA binding
HPY08_11675	COG2923	Belongs to the DsrF TusC family
HPY08_11680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY08_11685	COG2964	Protein conserved in bacteria
HPY08_11690	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY08_11700	COG2900	Belongs to the SlyX family
HPY08_11705	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY08_11710	COG0330	HflC and HflK could
HPY08_11715	COG0330	HflC and HflK could
HPY08_11720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY08_11725	COG1923	regulation of RNA biosynthetic process
HPY08_11730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY08_11735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY08_11745	COG0802	atpase or kinase
HPY08_11750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY08_11795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY08_11800	COG1162	GTPase activity
HPY08_11805	COG0688	phosphatidylethanolamine metabolic process
HPY08_11810	COG0471	metal ion transport
HPY08_11820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY08_11825	COG4942	peptidase
HPY08_11840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY08_11845	COG2816	NAD+ diphosphatase activity
HPY08_11850	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY08_11855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY08_11860	COG0085	RNA polymerase activity
HPY08_11865	COG0222	ribosome binding
HPY08_11870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY08_11880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY08_11885	COG0250	Participates in transcription elongation, termination and antitermination
HPY08_11890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY08_11895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY08_11920	COG1072	(Pantothenic acid kinase))
HPY08_11930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY08_11940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY08_11985	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY08_12000	COG3118	belongs to the thioredoxin family
HPY08_12005	COG0513	Belongs to the DEAD box helicase family
HPY08_12010	COG0248	Ppx GppA phosphatase
HPY08_12015	COG2205	protein histidine kinase activity
HPY08_12015	COG0784	Response regulator, receiver
HPY08_12020	COG2814	Major facilitator Superfamily
HPY08_12035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY08_12040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY08_12045	COG0511	ligase activity, forming carbon-carbon bonds
HPY08_12050	COG0439	Biotin carboxylase
HPY08_12055	COG2264	protein methyltransferase activity
HPY08_12060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY08_12065	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY08_12070	COG1609	Transcriptional regulator
HPY08_12085	COG0129	dihydroxy-acid dehydratase activity
HPY08_12090	COG3265	gluconokinase activity
HPY08_12100	COG0800	Aldolase
HPY08_12120	COG0840	transmembrane signaling receptor activity
HPY08_12125	COG1982	Orn Lys Arg decarboxylase major
HPY08_12130	COG0531	amino acid
HPY08_12135	COG3710	Transcriptional regulator
HPY08_12140	COG0789	Transcriptional regulator
HPY08_12155	COG0151	Belongs to the GarS family
HPY08_12165	COG0776	regulation of translation
HPY08_12170	COG1253	flavin adenine dinucleotide binding
HPY08_12180	COG3068	Protein conserved in bacteria
HPY08_12190	COG1573	uracil-dna glycosylase
HPY08_12195	COG0668	transmembrane transport
HPY08_12200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY08_12210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPY08_12220	COG0297	glycogen (starch) synthase activity
HPY08_12230	COG1216	Glycosyl transferase, family 2
HPY08_12230	COG0463	Glycosyl transferase, family 2
HPY08_12255	COG1596	polysaccharide export
HPY08_12275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY08_12355	COG1216	Glycosyl transferase, family 2
HPY08_12400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY08_12420	COG0859	PFAM glycosyl transferase family 9
HPY08_12430	COG1519	Transferase
HPY08_12435	COG0456	acetyltransferase
HPY08_12440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY08_12455	COG3642	lipopolysaccharide core region biosynthetic process
HPY08_12460	COG0859	PFAM glycosyl transferase family 9
HPY08_12465	COG0463	Glycosyl transferase, family 2
HPY08_12470	COG0859	PFAM glycosyl transferase family 9
HPY08_12475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY08_12480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY08_12490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY08_12495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY08_12500	COG2003	Belongs to the UPF0758 family
HPY08_12510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY08_12520	COG1309	transcriptional regulator
HPY08_12525	COG1560	Kdo2-lipid A biosynthetic process
HPY08_12530	COG1560	Kdo2-lipid A biosynthetic process
HPY08_12535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY08_12540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY08_12545	COG1561	YicC-like family, N-terminal region
HPY08_12550	COG2862	Uncharacterized protein family, UPF0114
HPY08_12555	COG1263	PTS System
HPY08_12555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY08_12560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY08_12570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY08_12600	COG0514	ATP-dependent DNA helicase (RecQ)
HPY08_12605	COG2962	Rard protein
HPY08_12610	COG0405	Gamma-glutamyltransferase
HPY08_12620	COG1280	lysine exporter protein (LysE YggA)
HPY08_12625	COG0210	DNA helicase
HPY08_12635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY08_12640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY08_12650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY08_12660	COG0747	negative chemotaxis
HPY08_12710	COG1309	transcriptional regulator
HPY08_12715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY08_12720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY08_12725	COG2960	long-chain fatty acid transporting porin activity
HPY08_12730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY08_12735	COG0583	DNA-binding transcription factor activity
HPY08_12805	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY08_12810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY08_12815	COG1739	Uncharacterized protein family UPF0029
HPY08_12820	COG1024	Enoyl-CoA hydratase
HPY08_12820	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY08_12825	COG0183	Belongs to the thiolase family
HPY08_12830	COG0583	DNA-binding transcription factor activity
HPY08_12835	COG2814	Major facilitator Superfamily
HPY08_12845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY08_12850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY08_12855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY08_12860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY08_12865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY08_12870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY08_12880	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY08_12885	COG3312	ion transport
HPY08_12890	COG1475	DNA binding
HPY08_12895	COG1192	Involved in chromosome partitioning
HPY08_12900	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY08_12905	COG0445	tRNA wobble uridine modification
HPY08_12910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY08_12915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY08_12920	COG0706	membrane insertase activity
HPY08_12930	COG0594	ribonuclease P activity
HPY08_12935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY08_12940	COG1126	abc transporter atp-binding protein
HPY08_12985	COG0217	transcriptional regulatory protein
HPY08_12990	COG2084	Dehydrogenase
HPY08_13005	COG2909	trisaccharide binding
HPY08_13010	COG0058	SHG alpha-glucan phosphorylase activity
HPY08_13015	COG1640	4-alpha-glucanotransferase
HPY08_13020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY08_13030	COG3501	Rhs element vgr protein
HPY08_13065	COG0471	metal ion transport
HPY08_13070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY08_13100	COG0671	phosphoesterase, PA-phosphatase related
HPY08_13110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY08_13120	COG1999	signal sequence binding
HPY08_13135	COG0786	glutamate:sodium symporter activity
HPY08_13155	COG1566	PFAM secretion protein HlyD family protein
HPY08_13165	COG3706	GGDEF domain
HPY08_13180	COG0813	purine-nucleoside phosphorylase activity
HPY08_13185	COG3272	Protein of unknown function (DUF1722)
HPY08_13195	COG0415	Belongs to the DNA photolyase family
HPY08_13200	COG1376	ErfK ybiS ycfS ynhG family protein
HPY08_13200	COG1388	LysM domain
HPY08_13210	COG0513	Belongs to the DEAD box helicase family
HPY08_13215	COG1770	oligopeptidase
HPY08_13245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY08_13250	COG0573	inorganic phosphate transmembrane transporter activity
HPY08_13255	COG0581	inorganic phosphate transmembrane transporter activity
HPY08_13260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY08_13280	COG0659	secondary active sulfate transmembrane transporter activity
HPY08_13290	COG0739	heme binding
HPY08_13295	COG5001	Diguanylate cyclase
HPY08_13295	COG3300	MHYT domain
HPY08_13300	COG0583	DNA-binding transcription factor activity
HPY08_13305	COG2814	Major facilitator Superfamily
HPY08_13325	COG1301	dicarboxylic acid transport
HPY08_13335	COG1342	Belongs to the UPF0251 family
HPY08_13370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY08_13375	COG0673	inositol 2-dehydrogenase activity
HPY08_13385	COG2771	luxR family
HPY08_13385	COG2200	EAL domain
HPY08_13390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY08_13400	COG0564	pseudouridine synthase activity
HPY08_13490	COG3501	Rhs element vgr protein
HPY08_13510	COG1869	D-ribose catabolic process
HPY08_13515	COG1129	ABC transporter
HPY08_13520	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY08_13525	COG1879	ABC-type sugar transport system periplasmic component
HPY08_13530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY08_13535	COG1609	Transcriptional regulator
HPY08_13545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY08_13555	COG0584	glycerophosphoryl diester phosphodiesterase
HPY08_13560	COG2271	Major facilitator Superfamily
HPY08_13595	COG0579	oxidoreductase
HPY08_13605	COG0242	peptide deformylase activity
HPY08_13620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_13625	COG1609	Transcriptional regulator
HPY08_13630	COG1017	nitric oxide dioxygenase activity
HPY08_13630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY08_13635	COG1320	monovalent cation:proton antiporter activity
HPY08_13640	COG2212	antiporter activity
HPY08_13660	COG2111	Na H antiporter
HPY08_13660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY08_13670	COG0589	response to stress
HPY08_13675	COG0814	amino acid
HPY08_13690	COG3530	Putative quorum-sensing-regulated virulence factor
HPY08_13700	COG5002	protein histidine kinase activity
HPY08_13700	COG5001	Diguanylate cyclase
HPY08_13705	COG1278	Cold shock
HPY08_13720	COG2304	oxidoreductase activity
HPY08_13740	COG0714	Associated with various cellular activities
HPY08_13745	COG0840	transmembrane signaling receptor activity
HPY08_13760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY08_13765	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY08_13775	COG3604	Transcriptional regulator
HPY08_13780	COG1017	nitric oxide dioxygenase activity
HPY08_13780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY08_13785	COG1278	Cold shock
HPY08_13790	COG3036	rescue of stalled ribosome
HPY08_13815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY08_13815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY08_13820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY08_13830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY08_13840	COG0516	GMP reductase activity
HPY08_13870	COG0513	Belongs to the DEAD box helicase family
HPY08_13875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY08_13880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY08_13885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY08_13890	COG3437	response regulator, receiver
HPY08_13890	COG0784	Response regulator, receiver
HPY08_13900	COG4191	Histidine kinase
HPY08_13900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY08_13910	COG1757	Na H antiporter
HPY08_13915	COG2814	Major facilitator Superfamily
HPY08_13925	COG3240	lipase activity
HPY08_13935	COG0840	transmembrane signaling receptor activity
HPY08_13940	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY08_13945	COG5380	lipid catabolic process
HPY08_13970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY08_13975	COG4605	iron ion homeostasis
HPY08_13980	COG4604	ABC transporter, ATP-binding protein
HPY08_13985	COG2207	Transcriptional regulator
HPY08_14000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY08_14015	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HPY08_14020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPY08_14060	COG0583	DNA-binding transcription factor activity
HPY08_14075	COG0745	RESPONSE REGULATOR receiver
HPY08_14105	COG3623	hexulose-6-phosphate isomerase
HPY08_14110	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY08_14115	COG0561	phosphatase activity
HPY08_14160	COG1335	isochorismatase
HPY08_14165	COG1741	Belongs to the pirin family
HPY08_14170	COG0583	DNA-binding transcription factor activity
HPY08_14175	COG0366	Alpha amylase catalytic
HPY08_14195	COG0745	RESPONSE REGULATOR receiver
HPY08_14200	COG5002	protein histidine kinase activity
HPY08_14225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY08_14240	COG0583	DNA-binding transcription factor activity
HPY08_14255	COG1686	Belongs to the peptidase S11 family
HPY08_14275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY08_14275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY08_14280	COG0509	glycine decarboxylation via glycine cleavage system
HPY08_14285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY08_14295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY08_14310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY08_14315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY08_14360	COG3041	Addiction module toxin RelE StbE family
HPY08_14400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY08_14470	COG0456	acetyltransferase
HPY08_14475	COG3617	BRO family, N-terminal domain
HPY08_14485	COG0346	lactoylglutathione lyase activity
HPY08_14540	COG0454	-acetyltransferase
HPY08_14580	COG0494	nUDIX hydrolase
HPY08_14630	COG0456	acetyltransferase
HPY08_14650	COG0346	lactoylglutathione lyase activity
HPY08_14675	COG0346	lactoylglutathione lyase activity
HPY08_14700	COG0456	acetyltransferase
HPY08_14775	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY08_14820	COG0454	-acetyltransferase
HPY08_14855	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY08_14885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY08_14980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY08_15000	COG1418	mRNA catabolic process
HPY08_15060	COG0454	-acetyltransferase
HPY08_15185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY08_15270	COG0384	phenazine biosynthesis protein PhzF
HPY08_15315	COG2161	toxin-antitoxin pair type II binding
HPY08_15320	COG4115	mRNA cleavage
HPY08_15490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY08_15555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY08_15580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY08_15635	COG3041	Addiction module toxin RelE StbE family
HPY08_15725	COG0384	phenazine biosynthesis protein PhzF
HPY08_15780	COG0494	nUDIX hydrolase
HPY08_15845	COG0346	lactoylglutathione lyase activity
HPY08_15875	COG3549	Plasmid maintenance system killer
HPY08_15880	COG3093	addiction module antidote protein HigA
HPY08_15910	COG5642	Protein of unknown function (DUF2384)
HPY08_15930	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY08_15935	COG2885	chlorophyll binding
HPY08_15940	COG0840	transmembrane signaling receptor activity
HPY08_15945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY08_15950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY08_15955	COG1621	beta-fructofuranosidase activity
HPY08_15965	COG1263	PTS System
HPY08_15965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY08_16055	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY08_16060	COG0583	DNA-binding transcription factor activity
HPY08_16085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY08_16110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY08_16120	COG2390	Transcriptional regulator
HPY08_16125	COG2897	thiosulfate sulfurtransferase activity
HPY08_16135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY08_16145	COG0302	gtp cyclohydrolase
HPY08_16150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY08_16150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY08_16155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY08_16160	COG1970	mechanosensitive ion channel activity
HPY08_16165	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY08_16175	COG1011	Hydrolase
HPY08_16180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY08_16185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY08_16200	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY08_16205	COG3842	ATPase activity
HPY08_16225	COG3104	oligopeptide transport
HPY08_16250	COG4166	transmembrane transport
HPY08_16255	COG4174	ABC transporter (Permease)
HPY08_16260	COG4239	(ABC) transporter, permease
HPY08_16265	COG4172	Belongs to the ABC transporter superfamily
HPY08_16270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY08_16285	COG0625	glutathione transferase activity
HPY08_16305	COG2050	protein possibly involved in aromatic compounds catabolism
HPY08_16320	COG1629	transport
HPY08_16320	COG4771	TonB-dependent receptor
HPY08_16325	COG0583	DNA-binding transcription factor activity
HPY08_16330	COG1042	CoA-binding domain protein
HPY08_16330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY08_16330	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY08_16350	COG0023	Translation Initiation Factor
HPY08_16360	COG3501	Rhs element vgr protein
HPY08_16395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY08_16400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY08_16465	COG0455	bacterial-type flagellum organization
HPY08_16470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY08_16470	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HPY08_16485	COG1061	Type III restriction enzyme res subunit
HPY08_16510	COG3140	Belongs to the UPF0181 family
HPY08_16525	COG0745	RESPONSE REGULATOR receiver
HPY08_16535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY08_16540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY08_16555	COG3706	GGDEF domain
HPY08_16605	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY08_16625	COG0737	Belongs to the 5'-nucleotidase family
HPY08_16630	COG3593	DNA synthesis involved in DNA repair
HPY08_16640	COG0583	DNA-binding transcription factor activity
HPY08_16645	COG2116	formate transmembrane transporter activity
HPY08_16655	COG3038	cytochrome b561
HPY08_16665	COG2200	EAL domain
HPY08_16680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY08_16685	COG0745	RESPONSE REGULATOR receiver
HPY08_16690	COG2205	protein histidine kinase activity
HPY08_16695	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY08_16695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY08_16695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY08_16695	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY08_16700	COG3158	transport of potassium into the cell
HPY08_16710	COG0523	cobalamin synthesis protein
HPY08_16715	COG0038	chloride channel
HPY08_16725	COG0156	8-amino-7-oxononanoate synthase activity
HPY08_16730	COG2205	protein histidine kinase activity
HPY08_16730	COG0784	Response regulator, receiver
HPY08_16735	COG0419	ATPase involved in DNA repair
HPY08_16740	COG0420	3'-5' exonuclease activity
HPY08_16745	COG1609	Transcriptional regulator
HPY08_16750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_16750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_16755	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY08_16760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY08_16760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY08_16760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY08_16765	COG0189	ligase activity
HPY08_16765	COG4067	protein conserved in archaea
HPY08_16775	COG0602	queuosine metabolic process
HPY08_16780	COG1328	CTP reductase activity
HPY08_16790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY08_16795	COG0840	transmembrane signaling receptor activity
HPY08_16800	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY08_16805	COG1760	l-serine dehydratase
HPY08_16810	COG2197	response regulator
HPY08_16815	COG3850	Histidine kinase
HPY08_16820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY08_16830	COG0243	molybdopterin cofactor binding
HPY08_16850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY08_16855	COG2197	response regulator
HPY08_16860	COG3851	Histidine kinase
HPY08_16865	COG2271	Major facilitator Superfamily
HPY08_16870	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY08_16880	COG3842	ATPase activity
HPY08_16885	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY08_16895	COG0183	Belongs to the thiolase family
HPY08_16910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY08_16925	COG3706	GGDEF domain
HPY08_16930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY08_16940	COG1979	alcohol dehydrogenase
HPY08_16955	COG4191	Histidine kinase
HPY08_16965	COG2271	Major facilitator Superfamily
HPY08_16970	COG0469	pyruvate kinase activity
HPY08_16975	COG2205	protein histidine kinase activity
HPY08_16975	COG0784	Response regulator, receiver
HPY08_16975	COG2198	Histidine kinase
HPY08_16980	COG1879	ABC-type sugar transport system periplasmic component
HPY08_16985	COG1803	Methylglyoxal synthase
HPY08_16990	COG1335	isochorismatase
HPY08_16995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY08_17000	COG0210	DNA helicase
HPY08_17005	COG1289	transmembrane transporter activity
HPY08_17035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY08_17040	COG4149	molybdate abc transporter
HPY08_17045	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY08_17050	COG1492	cobalamin metabolic process
HPY08_17090	COG4977	sequence-specific DNA binding
HPY08_17090	COG1917	Cupin 2, conserved barrel domain protein
HPY08_17095	COG4771	TonB-dependent receptor
HPY08_17100	COG2814	Major facilitator Superfamily
HPY08_17105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY08_17105	COG3433	isochorismatase activity
HPY08_17105	COG2226	methyltransferase
HPY08_17130	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY08_17135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY08_17155	COG1132	(ABC) transporter
HPY08_17160	COG1132	(ABC) transporter
HPY08_17170	COG0784	Response regulator, receiver
HPY08_17170	COG5002	protein histidine kinase activity
HPY08_17175	COG1879	ABC-type sugar transport system periplasmic component
HPY08_17185	COG2827	Endonuclease containing a URI domain
HPY08_17200	COG2926	Belongs to the UPF0265 family
HPY08_17215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY08_17220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY08_17225	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPY08_17230	COG0247	lactate metabolic process
HPY08_17235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY08_17240	COG3118	belongs to the thioredoxin family
HPY08_17265	COG4160	amino acid transport
HPY08_17270	COG4215	(ABC) transporter
HPY08_17275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY08_17280	COG1126	abc transporter atp-binding protein
HPY08_17290	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY08_17300	COG0494	nUDIX hydrolase
HPY08_17305	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY08_17315	COG1309	transcriptional regulator
HPY08_17320	COG0513	Belongs to the DEAD box helicase family
HPY08_17330	COG0814	amino acid
HPY08_17335	COG0840	transmembrane signaling receptor activity
HPY08_17340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY08_17345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY08_17350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPY08_17355	COG1984	allophanate hydrolase subunit 2
HPY08_17370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY08_17375	COG4181	ATPase activity
HPY08_17385	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY08_17390	COG5001	Diguanylate cyclase
HPY08_17390	COG1716	ATPase activity
HPY08_17400	COG0484	heat shock protein binding
HPY08_17415	COG0546	phosphoglycolate phosphatase activity
HPY08_17430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY08_17435	COG1368	sulfuric ester hydrolase activity
HPY08_17445	COG0513	Belongs to the DEAD box helicase family
HPY08_17460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY08_17470	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY08_17475	COG3397	chitin binding
HPY08_17480	COG3227	Zinc metalloprotease (Elastase)
HPY08_17495	COG1166	arginine decarboxylase activity
HPY08_17505	COG2239	Acts as a magnesium transporter
HPY08_17515	COG0527	aspartate kinase activity
HPY08_17520	COG0662	Cupin 2, conserved barrel domain protein
HPY08_17525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY08_17530	COG0456	acetyltransferase
HPY08_17535	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY08_17540	COG3186	Phenylalanine-4-hydroxylase
HPY08_17545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY08_17560	COG2264	protein methyltransferase activity
HPY08_17585	COG1253	flavin adenine dinucleotide binding
HPY08_17590	COG1765	OsmC-like protein
HPY08_17620	COG1252	NADH dehydrogenase
HPY08_17625	COG0531	amino acid
HPY08_17630	COG3706	GGDEF domain
HPY08_17640	COG4989	oxidoreductase activity
HPY08_17645	COG0366	Alpha amylase catalytic
HPY08_17655	COG2067	long-chain fatty acid transport protein
HPY08_17660	COG2267	carboxylic ester hydrolase activity
HPY08_17670	COG3227	Zinc metalloprotease (Elastase)
HPY08_17680	COG3047	cAMP biosynthetic process
HPY08_17690	COG1686	Belongs to the peptidase S11 family
HPY08_17695	COG0557	exoribonuclease II activity
HPY08_17700	COG1278	Cold shock
HPY08_17710	COG3048	D-serine ammonia-lyase activity
HPY08_17715	COG0583	DNA-binding transcription factor activity
HPY08_17735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY08_17745	COG1063	alcohol dehydrogenase
HPY08_17750	COG0156	8-amino-7-oxononanoate synthase activity
HPY08_17770	COG0346	lactoylglutathione lyase activity
HPY08_17795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY08_17800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY08_17805	COG0363	glucosamine-6-phosphate deaminase activity
HPY08_17810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY08_17835	COG1929	Belongs to the glycerate kinase type-1 family
HPY08_17840	COG2610	gluconate transmembrane transporter activity
HPY08_17845	COG3835	regulator
HPY08_17855	COG0748	coenzyme F420 binding
HPY08_17860	COG3721	Heme iron utilization protein
HPY08_17870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY08_17875	COG0811	peptide transport
HPY08_17880	COG0848	biopolymer transport protein
HPY08_17890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY08_17895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY08_17930	COG3217	Mosc domain protein beta barrel domain protein
HPY08_17930	COG0633	Ferredoxin
HPY08_17930	COG0633	Ferredoxin
HPY08_17930	COG3217	Mosc domain protein beta barrel domain protein
HPY08_17935	COG0418	dihydroorotase activity
HPY08_17940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY08_17945	COG2354	Protein conserved in bacteria
HPY08_17955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY08_17960	COG1278	Cold shock
HPY08_17975	COG2207	Transcriptional regulator
HPY08_17975	COG4753	response regulator
HPY08_17985	COG3706	GGDEF domain
HPY08_17990	COG1349	DNA-binding transcription factor activity
HPY08_18005	COG3833	ABC-type maltose transport systems, permease component
HPY08_18010	COG1175	transmembrane transport
HPY08_18020	COG3842	ATPase activity
HPY08_18025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY08_18040	COG0393	Putative heavy-metal-binding
HPY08_18050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY08_18055	COG0784	Response regulator, receiver
HPY08_18055	COG0835	chemotaxis
HPY08_18060	COG1846	Transcriptional regulator
HPY08_18065	COG3706	GGDEF domain
HPY08_18100	COG0583	DNA-binding transcription factor activity
HPY08_18105	COG5001	Diguanylate cyclase
HPY08_18115	COG1741	Belongs to the pirin family
HPY08_18120	COG3123	guanosine phosphorylase activity
HPY08_18130	COG2211	Major facilitator Superfamily
HPY08_18140	COG1067	ATP-dependent peptidase activity
HPY08_18150	COG4172	Belongs to the ABC transporter superfamily
HPY08_18170	COG0583	DNA-binding transcription factor activity
HPY08_18180	COG1620	l-lactate permease
HPY08_18195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY08_18205	COG0840	transmembrane signaling receptor activity
HPY08_18225	COG2258	MOSC domain
HPY08_18230	COG0513	Belongs to the DEAD box helicase family
HPY08_18240	COG1132	(ABC) transporter
HPY08_18250	COG1902	pentaerythritol trinitrate reductase activity
HPY08_18260	COG1280	lysine exporter protein (LysE YggA)
HPY08_18265	COG2207	Transcriptional regulator
HPY08_18285	COG1846	Transcriptional regulator
HPY08_18290	COG1764	response to oxidative stress
HPY08_18295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY08_18300	COG0697	spore germination
HPY08_18310	COG0700	Nucleoside recognition
HPY08_18315	COG3366	ferrous iron transmembrane transporter activity
HPY08_18320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY08_18330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY08_18335	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY08_18340	COG2259	Doxx family
HPY08_18365	COG0363	glucosamine-6-phosphate deaminase activity
HPY08_18385	COG4580	involved in the transport of maltose and maltodextrins
HPY08_18400	COG0840	transmembrane signaling receptor activity
HPY08_18415	COG0840	transmembrane signaling receptor activity
HPY08_18420	COG3706	GGDEF domain
HPY08_18430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY08_18435	COG1126	abc transporter atp-binding protein
HPY08_18445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY08_18450	COG4597	amino acid ABC transporter
HPY08_18455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY08_18460	COG2213	PTS system mannitol-specific
HPY08_18460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY08_18465	COG0246	Mannitol dehydrogenase
HPY08_18470	COG3722	fumarate hydratase activity
HPY08_18505	COG2910	NAD(P)H-binding
HPY08_18515	COG0840	transmembrane signaling receptor activity
HPY08_18520	COG4221	oxidoreductase activity
HPY08_18530	COG1901	pseudouridine methyltransferase
HPY08_18545	COG0531	amino acid
HPY08_18550	COG1982	Orn Lys Arg decarboxylase major
HPY08_18560	COG2197	response regulator
HPY08_18610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY08_18635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY08_18700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY08_18705	COG0840	transmembrane signaling receptor activity
HPY08_18710	COG0835	chemotaxis
HPY08_18715	COG0835	chemotaxis
HPY08_18720	COG0643	Histidine kinase
HPY08_18720	COG2198	Histidine kinase
HPY08_18740	COG0601	transmembrane transport
HPY08_18745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY08_18755	COG2194	sulfuric ester hydrolase activity
HPY08_18760	COG0642	Histidine kinase
HPY08_18765	COG0745	RESPONSE REGULATOR receiver
HPY08_18795	COG1444	tRNA N-acetyltransferase activity
HPY08_18800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine