locus-tag	class	description
EN12_00005	ENOG4105EAB	amino acid AbC transporter
EN12_00010	ENOG4105E5Q	amino acid AbC transporter
EN12_00025	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
EN12_00030	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
EN12_00035	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
EN12_00040	ENOG4105QTB	Flavodoxin
EN12_00045	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
EN12_00050	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
EN12_00055	ENOG4107QJE	Chromosome Partitioning Protein
EN12_00060	ENOG4105FA0	parb-like partition protein
EN12_00065	ENOG410684E	atp synthase
EN12_00070	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
EN12_00075	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EN12_00080	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EN12_00085	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EN12_00090	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
EN12_00095	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
EN12_00100	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
EN12_00105	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
EN12_00110	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
EN12_00115	ENOG4105CZQ	inner membrane transport protein YdhC
EN12_00120	ENOG4105F52	Transcriptional regulator
EN12_00125	ENOG4105CHU	acetyl-coa acetyltransferase
EN12_00130	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
EN12_00135	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
EN12_00140	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
EN12_00145	ENOG4108RR8	protoporphyrinogen oxidase
EN12_00190	ENOG4105EMY	transcriptional regulator
EN12_00195	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
EN12_00200	ENOG4105W0Z	cytoplasmic protein
EN12_00205	ENOG4105BZS	acriflavin resistance protein
EN12_00210	ENOG410624X	efflux transporter, rnd family, mfp subunit
EN12_00215	ENOG4105Y7M	Transcriptional regulator, TetR family
EN12_00220	ENOG4105C4R	Atp-dependent dna helicase
EN12_00225	ENOG4105MPD	Cytochrome
EN12_00265	ENOG4105DEF	Extracellular solute-binding protein, family 5
EN12_00270	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
EN12_00275	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EN12_00285	ENOG4108UK2	deaminase
EN12_00315	ENOG4108ZXE	
EN12_00350	ENOG4105DC8	reductase
EN12_00355	ENOG4105D6S	protein involved in catabolism of external DNA
EN12_00360	ENOG4105DGW	oligopeptidase A
EN12_00365	ENOG4105C4R	Atp-dependent dna helicase
EN12_00375	ENOG4108DMH	HTH_ARAC
EN12_00390	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EN12_00405	ENOG4105BZ1	(ABC) transporter
EN12_00410	ENOG4105E0K	tonB-dependent siderophore receptor
EN12_00415	ENOG4105E0A	ABC, transporter
EN12_00420	ENOG4105J76	Periplasmic binding protein
EN12_00425	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
EN12_00430	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
EN12_00435	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN12_00440	ENOG4105C5Y	PTS System
EN12_00450	ENOG4105DSJ	YicC domain protein
EN12_00455	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
EN12_00460	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
EN12_00465	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
EN12_00470	ENOG4105D1S	lipid A biosynthesis
EN12_00475	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
EN12_00480	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
EN12_00485	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_00495	ENOG4105KDC	50s ribosomal protein l28
EN12_00500	ENOG4105W0E	50S ribosomal protein L33
EN12_00510	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
EN12_00515	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
EN12_00520	ENOG4105M5K	heptosyltransferase
EN12_00525	ENOG4106WTF	Glycosyl transferase, family 2
EN12_00530	ENOG4105DKP	glycosyl transferase, family 9
EN12_00535	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
EN12_00565	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
EN12_00570	ENOG4108ST3	glycosyltransferase
EN12_00580	ENOG4105XA0	heptosyltransferase ii
EN12_00595	ENOG4107T94	Endo-14-beta-xylanase
EN12_00600	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
EN12_00605	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
EN12_00610	ENOG4107QKV	phosphomannomutase
EN12_00615	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
EN12_00620	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
EN12_00635	ENOG4105EY8	ABC transporter
EN12_00645	ENOG4105CEY	Amp-dependent synthetase and ligase
EN12_00650	ENOG4108EKI	Dehydrogenase
EN12_00660	ENOG4108UT6	Transferase hexapeptide repeat containing protein
EN12_00665	ENOG410600T	transposase
EN12_00695	ENOG4105D3Q	Sugar transferase
EN12_00700	ENOG4105CY0	Metallo-Beta-Lactamase
EN12_00705	ENOG4105CUY	Mechanosensitive ion channel
EN12_00710	ENOG4108RG0	uracil-dna glycosylase
EN12_00715	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
EN12_00720	ENOG4105R2J	Conserved Protein
EN12_00725	ENOG4105EIP	mannose-6-phosphate isomerase
EN12_00730	ENOG4105DKQ	ROK family
EN12_00740	ENOG4105K70	DNA-binding protein
EN12_00750	ENOG4105C12	Phosphoribosylglycinamide synthetase
EN12_00755	ENOG4105DC1	bifunctional purine biosynthesis protein purh
EN12_00760	ENOG4105W1Y	Transcriptional regulator
EN12_00765	ENOG4108M3R	transcriptional activator CadC
EN12_00770	ENOG4105D5Q	Arginine ornithine antiporter
EN12_00775	ENOG4105CXN	decarboxylase
EN12_00780	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_00795	ENOG4105E0K	tonB-dependent siderophore receptor
EN12_00800	ENOG4108UHU	Aldolase
EN12_00805	ENOG4105C6Z	Gluconate
EN12_00810	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
EN12_00815	ENOG4105C01	Dihydroxy-acid dehydratase
EN12_00820	ENOG4105DIQ	Transcriptional regulator
EN12_00825	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
EN12_00830	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
EN12_00835	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
EN12_00840	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
EN12_00845	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
EN12_00850	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
EN12_00855	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EN12_00870	ENOG4105D8G	Major Facilitator superfamily
EN12_00875	ENOG4105BZU	Histidine kinase
EN12_00880	ENOG4105C9X	ppx gppa phosphatase
EN12_00885	ENOG4105C1J	atp-dependent rna helicase
EN12_00890	ENOG4105K63	Thioredoxin
EN12_00895	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
EN12_00905	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
EN12_00915	ENOG4107QK7	reductase
EN12_00950	ENOG4105JIM	Phosphatidylserine synthase
EN12_00960	ENOG4105D4A	Cell wall formation (By similarity)
EN12_00965	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
EN12_00970	ENOG4105CS9	pantothenic acid kinase
EN12_00995	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EN12_01000	ENOG4105PM1	preprotein translocase subunit SecE
EN12_01005	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
EN12_01010	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
EN12_01015	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
EN12_01020	ENOG4108VZM	50s ribosomal protein L10
EN12_01025	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
EN12_01030	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EN12_01035	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EN12_01040	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
EN12_01045	ENOG4105E09	nadh pyrophosphatase
EN12_01050	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
EN12_01055	ENOG41062JF	Transcriptional regulator
EN12_01065	ENOG41063SB	peptidase
EN12_01070	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EN12_01080	ENOG4105C8P	)-transporter
EN12_01085	ENOG4105DJ4	phosphatidylserine decarboxylase
EN12_01090	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
EN12_01095	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
EN12_01145	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
EN12_01150	ENOG4105K8N	protein family UPF0079, ATPase
EN12_01155	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
EN12_01160	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
EN12_01165	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
EN12_01170	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
EN12_01175	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
EN12_01180	ENOG4107QJR	hflk protein
EN12_01185	ENOG4105EPW	hflc protein
EN12_01195	ENOG41069P5	Protein slyX homolog
EN12_01205	ENOG4108V1T	peptidylprolyl cis-trans isomerase
EN12_01210	ENOG4105WWK	YheO domain protein
EN12_01215	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
EN12_01220	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
EN12_01230	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
EN12_01235	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
EN12_01240	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
EN12_01245	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EN12_01250	ENOG4105W53	bacterioferritin-associated ferredoxin
EN12_01255	ENOG4108UQY	Iron-storage protein
EN12_01260	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
EN12_01265	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
EN12_01270	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
EN12_01275	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
EN12_01285	ENOG4105CDU	Replicative dna helicase
EN12_01290	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EN12_01295	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
EN12_01300	ENOG4107QP8	phosphohexose isomerase
EN12_01315	ENOG4105MYN	Zinc uptake regulation protein
EN12_01320	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
EN12_01325	ENOG4105P4Z	Phage shock protein G
EN12_01340	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
EN12_01345	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
EN12_01350	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
EN12_01385	ENOG4105EEQ	Na H antiporter
EN12_01390	ENOG4105C3R	Methionine synthase
EN12_01395	ENOG4105CFH	Aspartokinase
EN12_01400	ENOG4105C5R	Aminotransferase
EN12_01410	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EN12_01415	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
EN12_01420	ENOG41086KC	Transcriptional regulator
EN12_01425	ENOG4108UUM	single-stranded DNA-binding protein
EN12_01430	ENOG41062P1	Diguanylate cyclase phosphodiesterase
EN12_01450	ENOG4105E4G	Type IV pilus
EN12_01465	ENOG4107QHF	type ii secretion system protein e
EN12_01470	ENOG4105D7Q	type ii secretion system
EN12_01480	ENOG4105X0D	Fimbrial protein
EN12_01515	ENOG4105DFF	Rod shape-determining protein mreb
EN12_01520	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
EN12_01525	ENOG4105VQ7	Rod shape-determining protein MreD
EN12_01530	ENOG4108Z03	MAF-like protein
EN12_01535	ENOG4105C03	ribonuclease
EN12_01540	ENOG4105QD6	exported protein
EN12_01550	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
EN12_01555	ENOG4105CEU	Arginine dihydrolase
EN12_01575	ENOG41081QV	Universal stress protein
EN12_01590	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
EN12_01595	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
EN12_01600	ENOG4105D5Q	Arginine ornithine antiporter
EN12_01605	ENOG4105D5Q	Arginine ornithine antiporter
EN12_01610	ENOG4105EAH	synthase
EN12_01615	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
EN12_01620	ENOG4105K46	50S ribosomal protein l27
EN12_01625	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EN12_01630	ENOG4105DWK	Membrane
EN12_01635	ENOG4107XM3	UPF0442 protein
EN12_01645	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
EN12_01650	ENOG4105NWN	ApaG protein
EN12_01655	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
EN12_01660	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
EN12_01665	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
EN12_01670	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
EN12_01675	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
EN12_01730	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
EN12_01735	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
EN12_01740	ENOG4105CEN	a g-specific adenine glycosylase
EN12_01745	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
EN12_01750	ENOG4105CSV	Glutaminase
EN12_01755	ENOG4105CSA	Coproporphyrinogen iii oxidase
EN12_01760	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EN12_01770	ENOG4105VZ9	UPF0235 protein
EN12_01775	ENOG4108VIA	integral membrane protein
EN12_01780	ENOG4105II7	pyrroline-5-carboxylate reductase
EN12_01785	ENOG4105DFA	alanine racemase domain protein
EN12_01790	ENOG4105CZX	twitching motility protein
EN12_01795	ENOG4105CZX	twitching motility protein
EN12_01805	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
EN12_01810	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
EN12_01815	ENOG4108UJU	UPF0301 protein
EN12_01820	ENOG4105D7Z	glutathione synthase
EN12_01825	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
EN12_01830	ENOG4105RWS	endonuclease I
EN12_01835	ENOG4105GPY	SprT protein
EN12_01840	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
EN12_01850	ENOG4105CV1	Transketolase (EC 2.2.1.1)
EN12_01855	ENOG4108R4R	Iron-regulated virulence regulatory protein
EN12_01860	ENOG4105D05	Receptor
EN12_01865	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EN12_01870	ENOG4105BZA	Phosphoglycerate kinase
EN12_01880	ENOG4105D2N	Aldolase
EN12_01890	ENOG4105D64	Mechanosensitive ion channel
EN12_01895	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
EN12_01900	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
EN12_01905	ENOG4105MPN	Membrane
EN12_01910	ENOG4105CA9	Pyruvate kinase
EN12_01915	ENOG410804X	Transcriptional regulator
EN12_01920	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EN12_01925	ENOG4105CH5	extracellular solute-binding protein, family 7
EN12_01990	ENOG4105DR5	peptidase
EN12_02025	ENOG4108YGG	dna repair protein
EN12_02035	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
EN12_02045	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_02050	ENOG4105D58	Diguanylate phosphodiesterase
EN12_02055	ENOG4105DFP	Integrase
EN12_02065	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EN12_02070	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
EN12_02075	ENOG4105KTH	gatB Yqey
EN12_02080	ENOG4105VCC	30S ribosomal protein S21
EN12_02085	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EN12_02095	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
EN12_02100	ENOG4107ZVW	dihydroneopterin aldolase
EN12_02105	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN12_02110	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
EN12_02120	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
EN12_02125	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
EN12_02130	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
EN12_02135	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
EN12_02140	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
EN12_02145	ENOG4108K5P	(LipO)protein
EN12_02150	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EN12_02155	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
EN12_02160	ENOG4105C6T	cysteine synthase
EN12_02165	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
EN12_02170	ENOG4108I5D	sulfate abc transporter
EN12_02175	ENOG4105ECW	sulfate abc transporter
EN12_02180	ENOG4108IJ6	ABC transporter
EN12_02190	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
EN12_02195	ENOG4105Y3E	Modulates RecA activity (By similarity)
EN12_02200	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
EN12_02210	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
EN12_02265	ENOG4107QSA	Oxaloacetate decarboxylase
EN12_02270	ENOG4105D9Q	decarboxylase (Beta subunit)
EN12_02280	ENOG4105W39	Membrane
EN12_02290	ENOG4105D9M	gamma-glutamylcysteine synthetase
EN12_02295	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
EN12_02300	ENOG4108JU6	CBS domain protein
EN12_02305	ENOG4106KVJ	cytochrome C assembly protein
EN12_02310	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EN12_02315	ENOG4105K5M	30s ribosomal protein S16
EN12_02320	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
EN12_02325	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
EN12_02330	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
EN12_02335	ENOG4105C0H	protease
EN12_02340	ENOG4105C0H	protease
EN12_02350	ENOG4105D6Z	AFG1 family ATPase
EN12_02355	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
EN12_02360	ENOG4108UJD	30S ribosomal protein S9
EN12_02365	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
EN12_02370	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
EN12_02375	ENOG4105EIX	cytochrome c1
EN12_02380	ENOG4107MKT	Stringent starvation protein a
EN12_02385	ENOG4105KB2	stringent starvation protein b
EN12_02390	ENOG4105W4M	Transport-associated protein
EN12_02395	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
EN12_02400	ENOG41082RQ	UPF0102 protein
EN12_02405	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
EN12_02410	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
EN12_02415	ENOG410630P	Transcriptional regulator
EN12_02420	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
EN12_02425	ENOG41077A9	carbonic anhydrase
EN12_02430	ENOG4105CHH	sulfate transporter
EN12_02440	ENOG4105DA5	(ABC) transporter
EN12_02445	ENOG4105E3A	(ABC) transporter
EN12_02450	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
EN12_02455	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
EN12_02460	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN12_02465	ENOG4105DJ0	Poly(A) Polymerase
EN12_02470	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
EN12_02475	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EN12_02480	ENOG4105PW4	Sugar fermentation stimulation protein homolog
EN12_02490	ENOG4105CQ7	ATP-dependent helicase
EN12_02495	ENOG4105BZ4	penicillin-binding protein
EN12_02500	ENOG4105D78	K07001 NTE family protein
EN12_02505	ENOG4107QIJ	Aconitate hydratase 2
EN12_02510	ENOG4105XTV	UPF0231 protein
EN12_02515	ENOG4108YZA	Nitrogen regulatory protein pii
EN12_02535	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EN12_02545	ENOG4105E2V	Glycosyltransferase 36
EN12_02550	ENOG4105E2D	ec 3.2.1.52
EN12_02555	ENOG4105RD7	BadF BadG BcrA BcrD
EN12_02565	ENOG4108JQ7	(ABC) transporter
EN12_02570	ENOG4105C3U	ABC transporter
EN12_02575	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EN12_02585	ENOG4107QRA	Extracellular solute-binding protein, family 5
EN12_02590	ENOG4105BZU	Histidine kinase
EN12_02595	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
EN12_02600	ENOG4105IPI	Membrane
EN12_02605	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
EN12_02615	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
EN12_02630	ENOG4105DR5	peptidase
EN12_02635	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
EN12_02640	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
EN12_02645	ENOG4105FCK	Membrane
EN12_02650	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
EN12_02655	ENOG4105HBR	Rna-binding protein
EN12_02660	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
EN12_02665	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EN12_02670	ENOG4105EEI	dihydropteroate synthase
EN12_02675	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
EN12_02695	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
EN12_02700	ENOG4105CHV	Transcription elongation factor NusA
EN12_02705	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
EN12_02710	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
EN12_02715	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
EN12_02720	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
EN12_02725	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
EN12_02730	ENOG4105RT1	May be involved in cell division (By similarity)
EN12_02745	ENOG4106RZ4	Peptidase U32
EN12_02750	ENOG4105CFP	Peptidase U32
EN12_02755	ENOG4105BZU	Histidine kinase
EN12_02760	ENOG4105XPQ	lipid carrier protein
EN12_02765	ENOG4108YYD	acetyltransferase
EN12_02780	ENOG4105BZU	Histidine kinase
EN12_02815	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EN12_02900	ENOG4108R0M	Aminoglycoside
EN12_02920	ENOG4105KT5	UmuD protein
EN12_02945	ENOG4105CVR	type I restriction-modification system
EN12_02960	ENOG4105DZR	Type I site-specific deoxyribonuclease
EN12_02965	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
EN12_03010	ENOG4105D70	Integrase catalytic subunit
EN12_03030	ENOG4105F5W	AtP-binding protein
EN12_03080	ENOG4105T95	Thiol disulfide interChange protein
EN12_03135	ENOG4108UUM	single-stranded DNA-binding protein
EN12_03155	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
EN12_03180	ENOG4108YGG	dna repair protein
EN12_03205	ENOG4108KB1	transcriptional regulator, arac family
EN12_03290	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
EN12_03295	ENOG4105C1J	atp-dependent rna helicase
EN12_03300	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
EN12_03305	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
EN12_03310	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
EN12_03315	ENOG4105CRK	lysyL-tRNA synthetase
EN12_03320	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_03330	ENOG4105CPC	Aldo Keto reductase
EN12_03335	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
EN12_03345	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
EN12_03350	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
EN12_03355	ENOG4105HF0	Membrane
EN12_03360	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
EN12_03365	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
EN12_03375	ENOG41063Z6	transcriptional regulator, lysR family
EN12_03380	ENOG41080HT	Transcriptional regulator, arsr family
EN12_03385	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
EN12_03390	ENOG4105CJR	Integral membrane protein (MviN
EN12_03395	ENOG4105DTN	riboflavin biosynthesis protein ribF
EN12_03400	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
EN12_03405	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
EN12_03410	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
EN12_03415	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
EN12_03435	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN12_03440	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
EN12_03445	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
EN12_03450	ENOG4108NEV	two component transcriptional regulator, LytTR family
EN12_03455	ENOG4108HRK	Histidine kinase
EN12_03460	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
EN12_03475	ENOG4105C5H	ABC transporter
EN12_03480	ENOG4107SC1	transglycosylase
EN12_03485	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
EN12_03490	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EN12_03495	ENOG4108K0B	C-di-gmp phosphodiesterase
EN12_03500	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
EN12_03510	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
EN12_03515	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_03520	ENOG4105C34	Pseudouridine synthase
EN12_03525	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
EN12_03530	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EN12_03570	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
EN12_03575	ENOG4105CFP	Peptidase U32
EN12_03580	ENOG4105DH7	May be involved in recombination (By similarity)
EN12_03585	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EN12_03590	ENOG4105BZU	Histidine kinase
EN12_03600	ENOG4105C9X	ppx gppa phosphatase
EN12_03605	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
EN12_03610	ENOG4105C8U	phosphate abc transporter
EN12_03615	ENOG4105E2Z	phosphate ABC transporter (Permease
EN12_03620	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EN12_03630	ENOG4105CSR	polyphosphate kinase 2
EN12_03635	ENOG4106N3A	copper homeostasis protein cutc
EN12_03640	ENOG4105D3R	alkyl hydroperoxide reductase
EN12_03645	ENOG4105C5Q	Transcriptional regulator
EN12_03650	ENOG4107QP3	malate synthase g
EN12_03655	ENOG4108I9X	Isocitrate lyase
EN12_03660	ENOG4105W87	Cbs domain
EN12_03665	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
EN12_03670	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
EN12_03675	ENOG4105VIE	preprotein translocase, subunit YajC
EN12_03680	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EN12_03685	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EN12_03690	ENOG4105ECY	inositol monophosphatase
EN12_03695	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
EN12_03700	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
EN12_03705	ENOG4105C3J	Cysteine desulfurase
EN12_03710	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
EN12_03715	ENOG4108Z4V	iron-sulfur cluster assembly
EN12_03720	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
EN12_03725	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
EN12_03730	ENOG4108ZIT	Ferredoxin, 2FE-2S
EN12_03735	ENOG4105WVQ	Fe-S assembly protein IscX
EN12_03740	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
EN12_03745	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
EN12_03750	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
EN12_03760	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
EN12_03765	ENOG4105CUT	histidyl-tRNA synthetase
EN12_03770	ENOG4105N21	Membrane
EN12_03775	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
EN12_03780	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
EN12_03795	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EN12_03800	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EN12_03805	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EN12_03815	ENOG4106HK8	GPR1 FUN34 yaaH family protein
EN12_03820	ENOG4105WQI	isochorismatase
EN12_03825	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
EN12_03830	ENOG4105E4F	Isochorismate synthase
EN12_03835	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
EN12_03845	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
EN12_03850	ENOG4105DQ5	transport system permease protein
EN12_03855	ENOG4105TVJ	transport system, permease
EN12_03860	ENOG4105E0A	ABC, transporter
EN12_03870	ENOG41064T2	transcriptional regulator, lysR family
EN12_03875	ENOG4105EUZ	Beta-lactamase domain protein
EN12_03880	ENOG4105BZG	amino acid carrier protein
EN12_03885	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
EN12_03905	ENOG4106YYS	transcriptional regulatory protein
EN12_03910	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
EN12_03915	ENOG4105D9Q	decarboxylase (Beta subunit)
EN12_03920	ENOG4107QSA	Oxaloacetate decarboxylase
EN12_03935	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
EN12_03940	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
EN12_03945	ENOG4105CI0	Citrate lyase
EN12_03950	ENOG4105CHY	citrate lyase, alpha
EN12_03955	ENOG4105YGP	holo-ACP synthase CitX
EN12_03960	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
EN12_03975	ENOG4108Z4U	Ferredoxin
EN12_03980	ENOG4105DZ0	fad dependent oxidoreductase
EN12_04040	ENOG4105C26	Dehydrogenase
EN12_04060	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
EN12_04065	ENOG4107RK6	Methyl-accepting chemotaxis
EN12_04080	ENOG4105XB6	Toxin coregulated pilin
EN12_04095	ENOG4105GRU	toxin co-regulated pilus biosynthesis outer membrane protein C
EN12_04115	ENOG4107QHF	type ii secretion system protein e
EN12_04120	ENOG4108VEY	type ii secretion system
EN12_04135	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
EN12_04140	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_04155	ENOG4105DR5	peptidase
EN12_04165	ENOG4105F88	accessory colonization factor AcfD
EN12_04175	ENOG4105DFP	Integrase
EN12_04180	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
EN12_04185	ENOG4108Z1B	Cyclase dehydrase
EN12_04190	ENOG4105VDB	UPF0125 protein
EN12_04195	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
EN12_04200	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
EN12_04205	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
EN12_04210	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EN12_04215	ENOG4105CFG	Acts as a chaperone (By similarity)
EN12_04220	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EN12_04250	ENOG4105CFC	Transporter
EN12_04255	ENOG4108Z6B	deaminase
EN12_04265	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
EN12_04275	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
EN12_04280	ENOG4108RS6	transposase
EN12_04300	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
EN12_04305	ENOG4108R96	Methyltransferase, YaeB family
EN12_04310	ENOG4105NRA	50s ribosomal protein l31 type b
EN12_04320	ENOG4105CFC	Transporter
EN12_04325	ENOG4108UPT	UPF0178 protein
EN12_04335	ENOG4108428	Inherit from COG: -acetyltransferase
EN12_04350	ENOG4105WP7	tRNA pseudouridine synthase C
EN12_04355	ENOG4105DR9	pseudouridine synthase
EN12_04360	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
EN12_04365	ENOG4105CTB	Polyprenyl synthetase
EN12_04375	ENOG4105E14	MotA TolQ exbB proton channel
EN12_04385	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
EN12_04390	ENOG4105ETT	transcriptional Regulator, LysR family
EN12_04395	ENOG4105M08	Membrane
EN12_04400	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
EN12_04405	ENOG4105EWT	decarboxylase family
EN12_04410	ENOG4105BZU	Histidine kinase
EN12_04420	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
EN12_04425	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
EN12_04430	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
EN12_04435	ENOG4105D01	(LipO)protein
EN12_04440	ENOG4108UMI	ABC transporter, permease
EN12_04445	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
EN12_04450	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
EN12_04455	ENOG4105D4X	repressor
EN12_04460	ENOG4105C5Y	PTS System
EN12_04465	ENOG4105CG3	alpha amylase, catalytic region
EN12_04495	ENOG4105BZS	acriflavin resistance protein
EN12_04500	ENOG4107ZF2	Phosphatase
EN12_04505	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
EN12_04515	ENOG4108UW5	maltose o-acetyltransferase
EN12_04535	ENOG4105D7W	serine acetyltransferase
EN12_04545	ENOG4105Q84	sucrose synthase
EN12_04555	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
EN12_04570	ENOG4108MA4	Peptidase M66
EN12_04585	ENOG4105D3Q	Sugar transferase
EN12_04595	ENOG4105DAY	polysaccharide export protein
EN12_04600	ENOG4105D75	Capsular exopolysaccharide family
EN12_04620	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EN12_04630	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
EN12_04635	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
EN12_04640	ENOG4108Z43	UPF0250 protein
EN12_04645	ENOG4105DZ1	carboxypeptidase
EN12_04650	ENOG4105K6T	rare lipoprotein A
EN12_04655	ENOG4105CNI	cell division protein FtsW
EN12_04660	ENOG4105CJN	penicillin-binding protein
EN12_04665	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
EN12_04670	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
EN12_04675	ENOG4105DJF	DNA polymerase III, delta' subunit
EN12_04680	ENOG4108U2H	Rare lipoprotein B
EN12_04685	ENOG4105C8T	Leucyl-tRNA synthetase
EN12_04690	ENOG4107PAI	alpha helical protein
EN12_04695	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
EN12_04700	ENOG4108JU5	Magnesium and cobalt efflux protein
EN12_04705	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
EN12_04710	ENOG4105C9A	Phoh family
EN12_04715	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
EN12_04720	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
EN12_04725	ENOG4105C5Y	PTS System
EN12_04735	ENOG4105KZ7	phosphocarrier protein hpr
EN12_04740	ENOG4105C6T	cysteine synthase
EN12_04745	ENOG4105EXN	Sulfate transport protein CysZ
EN12_04750	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
EN12_04755	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EN12_04760	ENOG41081QG	Porin Gram-negative type
EN12_04770	ENOG4108Z6Z	Transcriptional regulator
EN12_04775	ENOG4105G5H	Membrane
EN12_04780	ENOG4107QX8	SPFH domain, Band 7 family protein
EN12_04785	ENOG4107QR8	Thioredoxin
EN12_04795	ENOG4105E1F	short-chain dehydrogenase reductase
EN12_04800	ENOG4105ECP	epimerase
EN12_04805	ENOG4108RE9	Phosphodiesterase
EN12_04820	ENOG4108TU9	TRANSCRIPTIONal
EN12_04825	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
EN12_04830	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
EN12_04835	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
EN12_04840	ENOG4105DUX	Transporter
EN12_04845	ENOG4105MDZ	Transcriptional activator rfaH
EN12_04850	ENOG4105CAQ	asparagine synthetase
EN12_04855	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
EN12_04860	ENOG4105E2R	ROK family
EN12_04865	ENOG4105CE4	GlcNAc 6-P deacetylase
EN12_04870	ENOG4105CI1	PTS System
EN12_04875	ENOG4105CX6	glutaminyL-tRNA synthetase
EN12_04885	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
EN12_04890	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
EN12_04895	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
EN12_04900	ENOG4108S3P	Sporulation domain protein
EN12_04905	ENOG4105E96	Colicin v production protein
EN12_04910	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
EN12_04915	ENOG4105D3Y	Na H antiporter
EN12_04920	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
EN12_04930	ENOG4105EIY	sodium-type flagellar protein motY
EN12_04935	ENOG4106WH9	Protein of unknown function (DUF2753)
EN12_04940	ENOG4108UYE	Lactoylglutathione lyase
EN12_04945	ENOG4105CSM	endonuclease III
EN12_04950	ENOG4105DZB	Electron transport complex
EN12_04955	ENOG4108UQQ	Electron transport complex
EN12_04960	ENOG4105D6A	Electron transport complex
EN12_04970	ENOG4108R3D	Electron transport complex
EN12_04990	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
EN12_05000	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_05010	ENOG4105CHW	UPF0052 protein
EN12_05015	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EN12_05020	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
EN12_05025	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EN12_05030	ENOG4105M00	molybdopterin converting factor, subunit 1
EN12_05035	ENOG4108ZAF	Molybdopterin
EN12_05040	ENOG4105BZU	Histidine kinase
EN12_05055	ENOG4108I5U	Uridine phosphorylase
EN12_05065	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
EN12_05070	ENOG4105D1F	ATP-binding protein
EN12_05080	ENOG4105DBI	uridine monophosphokinase
EN12_05085	ENOG4108GAE	asmA family
EN12_05090	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
EN12_05100	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
EN12_05105	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
EN12_05130	ENOG4105CHU	acetyl-coa acetyltransferase
EN12_05135	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
EN12_05140	ENOG41069NU	Nitroreductase
EN12_05145	ENOG4105EJC	lysr family transcriptional regulator
EN12_05150	ENOG4105I93	response regulator
EN12_05160	ENOG4105WD1	Membrane
EN12_05165	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
EN12_05170	ENOG4107QMP	dna polymerase iii subunits gamma and tau
EN12_05175	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
EN12_05180	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
EN12_05185	ENOG4105KRS	Proteinase inhibitor
EN12_05195	ENOG4105UBK	short-chain dehydrogenase reductase
EN12_05200	ENOG4105ERU	peptidase
EN12_05210	ENOG4108XM1	transcriptional regulator AsnC family
EN12_05215	ENOG4105C29	acyl-CoA thioesterase
EN12_05235	ENOG4105BZU	Histidine kinase
EN12_05240	ENOG41082YX	Transcriptional regulator, arsr family
EN12_05245	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EN12_05270	ENOG4108V1U	phospholipid-binding protein
EN12_05290	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EN12_05305	ENOG4107YTP	response regulator receiver protein
EN12_05315	ENOG4105BZU	Histidine kinase
EN12_05320	ENOG4105BZU	Histidine kinase
EN12_05325	ENOG4105BZU	Histidine kinase
EN12_05330	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_05345	ENOG4107QSI	ABC, transporter
EN12_05350	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
EN12_05355	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EN12_05360	ENOG4105C3U	ABC transporter
EN12_05365	ENOG4108JQ7	(ABC) transporter
EN12_05370	ENOG4105CHF	Glutathione S-transferase
EN12_05375	ENOG4108DNC	Involved in acetate metabolism (By similarity)
EN12_05380	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
EN12_05385	ENOG4105PQ6	UPF0208 membrane protein
EN12_05390	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
EN12_05400	ENOG4105C7J	ABC transporter, permease
EN12_05405	ENOG4108JJB	ABC transporter
EN12_05410	ENOG4105BZU	Histidine kinase
EN12_05415	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
EN12_05420	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EN12_05430	ENOG4105D1H	recombination factor protein RarA
EN12_05435	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
EN12_05440	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EN12_05445	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
EN12_05450	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
EN12_05455	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
EN12_05460	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
EN12_05470	ENOG4105D0M	Protease HtpX homolog
EN12_05480	ENOG4107FW0	short-chain dehydrogenase reductase
EN12_05495	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
EN12_05505	ENOG4105RHG	
EN12_05515	ENOG4107QTF	adenylosuccinate lyase
EN12_05520	ENOG41075W9	High frequency lysogenization protein HflD homolog
EN12_05525	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
EN12_05530	ENOG4107RE1	Inosine-guanosine kinase
EN12_05540	ENOG4107S6Z	Na H antiporter
EN12_05545	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
EN12_05550	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
EN12_05555	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EN12_05560	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
EN12_05565	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
EN12_05570	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
EN12_05575	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
EN12_05580	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
EN12_05585	ENOG4108R99	pseudouridine synthase
EN12_05595	ENOG4105VEQ	Cold shock protein
EN12_05600	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
EN12_05605	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EN12_05615	ENOG41090BQ	Glutaredoxin
EN12_05620	ENOG4108EKI	Dehydrogenase
EN12_05625	ENOG4106KNT	transcriptional regulator
EN12_05630	ENOG4105DY8	decarboxylase
EN12_05640	ENOG4105DWU	Membrane
EN12_05665	ENOG4105CUX	Signal transduction histidine kinase
EN12_05675	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
EN12_05690	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
EN12_05695	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
EN12_05700	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
EN12_05705	ENOG41081XQ	Conserved Protein
EN12_05710	ENOG4105C9M	aspartyl-trna synthetase
EN12_05715	ENOG4107104	thymidine kinase
EN12_05720	ENOG4105CK2	sodium dicarboxylate symporter
EN12_05725	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
EN12_05730	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
EN12_05735	ENOG4105DK0	Indole-3-glycerol phosphate synthase
EN12_05740	ENOG4108I0Q	anthranilate phosphoribosyltransferase
EN12_05745	ENOG4105DDQ	anthranilate synthase
EN12_05750	ENOG4105CRQ	synthase (Component I)
EN12_05760	ENOG4105DB7	PHP domain protein
EN12_05765	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
EN12_05770	ENOG4105FE9	pseudouridine synthase
EN12_05775	ENOG4108JJ8	(ABC) transporter
EN12_05780	ENOG4108JJ9	ABC, transporter
EN12_05785	ENOG4105C3M	thioredoxin reductase
EN12_05800	ENOG4105C9B	Cysteine desulfurase
EN12_05805	ENOG4105BZU	Histidine kinase
EN12_05810	ENOG4107GZ4	SanA protein
EN12_05820	ENOG4107R1I	NAD-dependent malic enzyme
EN12_05830	ENOG4105C8V	SAICAR synthetase
EN12_05850	ENOG4108ZG0	Ompa motb domain protein
EN12_05865	ENOG4105CQB	FAD linked oxidase domain protein
EN12_05875	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
EN12_05885	ENOG4105C84	Histidine ammonia-lyase
EN12_05890	ENOG4105CGP	Urocanate hydratase
EN12_05895	ENOG41088SP	formiminoglutamate hydrolase
EN12_05900	ENOG4105CI2	imidazolone-5-propionate hydrolase
EN12_05905	ENOG4105CZE	histidine utilization repressor
EN12_05920	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
EN12_05930	ENOG4105BZU	Histidine kinase
EN12_05935	ENOG4105CQ2	DNA polymerase
EN12_05940	ENOG4105WH1	Two component transcriptional regulator luxr family
EN12_05945	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
EN12_05975	ENOG4105BZU	Histidine kinase
EN12_05985	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EN12_05990	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
EN12_05995	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
EN12_06010	ENOG4105FQ6	thiopurine methyltransferase
EN12_06025	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
EN12_06030	ENOG41067MG	lrgb family
EN12_06040	ENOG4105CJB	Exodeoxyribonuclease I
EN12_06045	ENOG4108ETY	sodium dicarboxylate symporter
EN12_06050	ENOG4105E0X	reductase
EN12_06060	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
EN12_06065	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
EN12_06070	ENOG4108YZT	Adenosylcobinamide kinase
EN12_06085	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
EN12_06090	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
EN12_06105	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_06130	ENOG4107QK7	reductase
EN12_06135	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EN12_06140	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EN12_06145	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
EN12_06150	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EN12_06155	ENOG4105C72	UPF0176 protein
EN12_06165	ENOG4105S8Q	sugar efflux transporter
EN12_06175	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
EN12_06205	ENOG4105EAQ	(twin-arginine translocation) pathway signal
EN12_06210	ENOG4105C5X	domain protein
EN12_06225	ENOG4105CH5	extracellular solute-binding protein, family 7
EN12_06235	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EN12_06250	ENOG41067TZ	transcriptional regulator, MarR family
EN12_06255	ENOG4105C94	Transporter
EN12_06265	ENOG4105VZJ	PTS System
EN12_06275	ENOG4105VCP	PTS System
EN12_06280	ENOG4105F8D	glycoside hydrolase family 4
EN12_06285	ENOG410901P	UPF0249 protein
EN12_06290	ENOG41060NJ	transcriptional regulator
EN12_06295	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
EN12_06300	ENOG4105DJ9	glucan biosynthesis protein
EN12_06305	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_06320	ENOG4105CGF	Aromatic amino acid aminotransferase
EN12_06330	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EN12_06340	ENOG4105C5S	asparaginyl-tRNA synthetase
EN12_06345	ENOG4108NVR	Methyl-accepting chemotaxis
EN12_06350	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
EN12_06355	ENOG4105EJQ	L-serine dehydratase
EN12_06360	ENOG4105C44	Serine transporter
EN12_06365	ENOG4105P8F	nudix hydrolase
EN12_06370	ENOG4105CRQ	synthase (Component I)
EN12_06385	ENOG4105CM6	amino acid regulated cytosolic protein
EN12_06395	ENOG4108JU8	Transcriptional regulator
EN12_06400	ENOG4105D9U	N-acetyltransferase
EN12_06415	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EN12_06420	ENOG4108NVR	Methyl-accepting chemotaxis
EN12_06425	ENOG4105C8P	)-transporter
EN12_06430	ENOG4105BZU	Histidine kinase
EN12_06435	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_06440	ENOG4108MJ5	VirK protein
EN12_06445	ENOG4105RW8	MltA-interacting MipA family protein
EN12_06450	ENOG4105EB3	Histidine kinase
EN12_06455	ENOG4107EXC	regulatoR
EN12_06480	ENOG4105C2J	ABC transporter
EN12_06485	ENOG4107SDZ	Galactoside transport system permease protein mglC
EN12_06515	ENOG41073TP	transcriptional regulator
EN12_06520	ENOG4105CR4	methylisocitrate lyase
EN12_06525	ENOG4105BZN	citrate synthase
EN12_06530	ENOG4108I0Z	Aconitate hydratase
EN12_06535	ENOG4105C7F	AcnD-accessory protein PrpF
EN12_06540	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EN12_06555	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
EN12_06565	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
EN12_06570	ENOG4105F1J	Homogentisate 1,2-dioxygenase
EN12_06580	ENOG4108RXX	maleylacetoacetate isomerase
EN12_06585	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EN12_06590	ENOG4105BZU	Histidine kinase
EN12_06600	ENOG4106TD9	Diguanylate cyclase
EN12_06605	ENOG4105DR4	Methyltransferase
EN12_06610	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
EN12_06615	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
EN12_06620	ENOG4108MN8	Membrane
EN12_06625	ENOG4105CDA	abc transporter atp-binding protein
EN12_06630	ENOG4105DRP	amino acid AbC transporter
EN12_06635	ENOG4105EZ7	amino acid ABC transporter
EN12_06640	ENOG4107QXX	ABC transporter
EN12_06650	ENOG410667J	hydrolase
EN12_06655	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
EN12_06660	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
EN12_06680	ENOG4105BZU	Histidine kinase
EN12_06690	ENOG4105BZU	Histidine kinase
EN12_06695	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
EN12_06700	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
EN12_06710	ENOG4105BZU	Histidine kinase
EN12_06730	ENOG4105CQ7	ATP-dependent helicase
EN12_06740	ENOG4105R8A	Heat shock protein
EN12_06745	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
EN12_06750	ENOG4105EJC	lysr family transcriptional regulator
EN12_06755	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
EN12_06760	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
EN12_06765	ENOG4105KPY	Small multidrug resistance protein
EN12_06770	ENOG4108NVR	Methyl-accepting chemotaxis
EN12_06775	ENOG4108VYJ	response regulator receiver protein
EN12_06785	ENOG4105CBS	Chea signal transduction histidine kinase
EN12_06790	ENOG4105CBS	Chea signal transduction histidine kinase
EN12_06795	ENOG4105BZU	Histidine kinase
EN12_06805	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
EN12_06810	ENOG4108V3W	Chemotaxis protein, CheW
EN12_06815	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_06820	ENOG4108N3W	hemolysin secretion protein
EN12_06825	ENOG4107SDU	Methyl-accepting chemotaxis
EN12_06830	ENOG4105C1J	atp-dependent rna helicase
EN12_06840	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
EN12_06845	ENOG4105CW7	secretion protein, HlyD family
EN12_06850	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
EN12_06855	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_06860	ENOG4105CTD	carboxy-peptidase
EN12_06865	ENOG4108WC9	type VI secretion system effector, hcp1 family
EN12_06870	ENOG4105CS6	Rhs element vgr protein
EN12_06895	ENOG410829K	Lysine exporter protein (Lyse ygga)
EN12_06900	ENOG4105BZG	amino acid carrier protein
EN12_06915	ENOG4107RUE	extracellular solute-binding protein family 1
EN12_06920	ENOG4107RUE	extracellular solute-binding protein family 1
EN12_06925	ENOG4105D38	putrescine abc transporter
EN12_06930	ENOG4105F38	ABC transporter, permease
EN12_06935	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EN12_06955	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
EN12_06960	ENOG4105Q9Y	Universal stress protein
EN12_06965	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
EN12_06980	ENOG4105C59	p-type ATPase
EN12_06990	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
EN12_07005	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
EN12_07020	ENOG4105BZU	Histidine kinase
EN12_07045	ENOG4108RC6	RTX toxin
EN12_07050	ENOG4105EUK	rtx toxin RtxA
EN12_07060	ENOG4107927	Cholera enterotoxin, A subunit
EN12_07065	ENOG4105MQ5	zona occludens toxin
EN12_07100	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
EN12_07120	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
EN12_07205	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
EN12_07210	ENOG4105DAN	ATP-dependent protease
EN12_07215	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
EN12_07225	ENOG4105C5H	ABC transporter
EN12_07235	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
EN12_07240	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
EN12_07245	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
EN12_07250	ENOG4105C7I	Dehydrogenase
EN12_07260	ENOG4105CD8	aminopeptidase N
EN12_07270	ENOG4105CN1	protease
EN12_07275	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
EN12_07280	ENOG4108ZGC	gaf domain protein
EN12_07285	ENOG4105BZ1	(ABC) transporter
EN12_07290	ENOG4105H2K	paraquat-inducible protein a
EN12_07295	ENOG4105DY2	Paraquat-inducible protein b
EN12_07300	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
EN12_07305	ENOG4105QNR	S1 RNA binding domain protein
EN12_07320	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
EN12_07330	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
EN12_07345	ENOG4105QAX	Iron-sulfur
EN12_07350	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
EN12_07360	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
EN12_07380	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
EN12_07385	ENOG4105C5H	ABC transporter
EN12_07390	ENOG4105BZU	Histidine kinase
EN12_07395	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_07405	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
EN12_07410	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EN12_07415	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
EN12_07420	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
EN12_07445	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
EN12_07450	ENOG4106IUH	DTW domain containing protein
EN12_07460	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_07465	ENOG4107TT5	NLP P60 protein
EN12_07475	ENOG4105FGM	Fructosamine kinase
EN12_07485	ENOG4107QI1	Mate efflux family protein
EN12_07505	ENOG41067XB	TonB family
EN12_07510	ENOG4109015	Biopolymer transport protein exbD tolR
EN12_07540	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
EN12_07545	ENOG4108IJ9	(ABC) transporter
EN12_07550	ENOG4105E98	transcriptional regulator DeoR family
EN12_07555	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
EN12_07560	ENOG4105XEP	YhcH YjgK YiaL family protein
EN12_07565	ENOG4105M4H	endoribonuclease L-psp
EN12_07570	ENOG4105DDV	Transcriptional regulator (LacI family
EN12_07575	ENOG4105CS2	ec 3.2.1.21
EN12_07580	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
EN12_07595	ENOG4107QZV	Type I secretion membrane fusion protein
EN12_07605	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EN12_07610	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EN12_07615	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EN12_07620	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
EN12_07625	ENOG4105C4M	(Ubiquinol oxidase) subunit I
EN12_07635	ENOG4105C9Q	fumarate hydratase class II
EN12_07665	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
EN12_07670	ENOG4105DUM	transcriptional regulator, lysR family
EN12_07675	ENOG4108TWJ	NADH dehydrogenase subunit 5
EN12_07685	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
EN12_07695	ENOG4105CH6	catalase
EN12_07715	ENOG4105C7K	acetolactate synthase
EN12_07725	ENOG4105BZU	Histidine kinase
EN12_07730	ENOG4106TD9	Diguanylate cyclase
EN12_07735	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
EN12_07740	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
EN12_07745	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
EN12_07775	ENOG4105BZU	Histidine kinase
EN12_07790	ENOG4107R88	Chemotaxis protein (CheV)
EN12_07800	ENOG4106YYS	transcriptional regulatory protein
EN12_07805	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
EN12_07820	ENOG4107V40	secretion protein, HlyD family
EN12_07840	ENOG4105CVG	Homoserine O-transsuccinylase
EN12_07845	ENOG41090FY	type IV pilus biogenesis stability protein PilW
EN12_07855	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
EN12_07860	ENOG4108VKG	metal-dependent hydrolase
EN12_07870	ENOG4105F04	LysR family Transcriptional regulator
EN12_07890	ENOG4105DFG	type I secretion outer membrane protein
EN12_07895	ENOG4105CDV	Ompa motb domain protein
EN12_07900	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
EN12_07905	ENOG4105E3Q	saccharopine dehydrogenase
EN12_07915	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
EN12_07930	ENOG4108I0Y	(ABC) transporter
EN12_07935	ENOG4105UQX	Mate efflux family protein
EN12_07940	ENOG4105CGD	Nad-dependent epimerase dehydratase
EN12_07950	ENOG4105C2C	drug resistance transporter, Bcr CflA
EN12_07955	ENOG4105I08	Pseudouridine synthase
EN12_07960	ENOG4105CFI	type iii restriction protein res subunit
EN12_07980	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
EN12_08000	ENOG4108N3W	hemolysin secretion protein
EN12_08030	ENOG4105KXC	Collagenase
EN12_08040	ENOG4105BZU	Histidine kinase
EN12_08045	ENOG4105BZU	Histidine kinase
EN12_08050	ENOG4105CJW	magnesium transporter
EN12_08065	ENOG4105C44	Serine transporter
EN12_08075	ENOG4105CJ1	ABC, transporter
EN12_08080	ENOG4107QWP	ABC-2 type transporter
EN12_08090	ENOG4105XZD	Fe-S protein
EN12_08100	ENOG4105VNH	ABC transporter solute-binding protein
EN12_08105	ENOG4105CXZ	ABC transporter, permease
EN12_08110	ENOG4108VGW	abc transporter atp-binding protein
EN12_08115	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
EN12_08120	ENOG4108W1A	pseudouridine synthase
EN12_08125	ENOG4105C8J	)-transporter
EN12_08130	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
EN12_08135	ENOG4105C28	cystathionine
EN12_08140	ENOG4108R3E	Dna-3-methyladenine glycosylase i
EN12_08155	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
EN12_08170	ENOG41087YS	Phage shock protein A
EN12_08175	ENOG4105E51	psp operon transcriptional activator
EN12_08180	ENOG4108J59	Extracellular solute-binding protein, family 5
EN12_08185	ENOG4108I5W	peptide transport system, permease protein
EN12_08190	ENOG4108EU3	peptide transport system, permease
EN12_08195	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
EN12_08200	ENOG4108JQ2	peptide transport system atp-binding protein
EN12_08215	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
EN12_08235	ENOG4107QY8	reductase
EN12_08255	ENOG4105TMB	Formate nitrite transporter
EN12_08265	ENOG4108535	NAD dependent epimerase/dehydratase family
EN12_08270	ENOG4105GFG	DUF218 domain
EN12_08280	ENOG4107835	probably involved in intracellular septation (By similarity)
EN12_08285	ENOG4105NAU	thioesterase Superfamily protein
EN12_08290	ENOG4105K9H	YciI-like protein
EN12_08300	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
EN12_08330	ENOG4105CCT	upf0313 protein
EN12_08340	ENOG4105EW9	transcriptional regulator AsnC family
EN12_08345	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
EN12_08350	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
EN12_08355	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
EN12_08360	ENOG4106371	Methyltransferase
EN12_08365	ENOG4107S90	membrAne
EN12_08370	ENOG4106WF9	DNA-binding transcriptional regulator TorR
EN12_08375	ENOG4108SBI	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
EN12_08380	ENOG4105ETE	Transcriptional regulator (LacI family
EN12_08385	ENOG4105HP8	regulator of competence-specific genes
EN12_08405	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
EN12_08410	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
EN12_08415	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
EN12_08420	ENOG4105RKX	Protein of unknown function (DUF2498)
EN12_08425	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
EN12_08435	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
EN12_08440	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
EN12_08445	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
EN12_08455	ENOG4107QPN	acyl-Coa dehydrogenase
EN12_08460	ENOG41067SE	Tetr family transcriptional regulator
EN12_08470	ENOG4105MTM	Protein of unknown function (DUF1496)
EN12_08475	ENOG4105C26	Dehydrogenase
EN12_08480	ENOG4108R86	Transcriptional regulator
EN12_08505	ENOG4105F1S	paraquat-inducible protein a
EN12_08510	ENOG4105DY2	Paraquat-inducible protein b
EN12_08535	ENOG4105DFP	Integrase
EN12_08545	ENOG4105C0D	helicase
EN12_08565	ENOG4105DZR	Type I site-specific deoxyribonuclease
EN12_08585	ENOG4105CVR	type I restriction-modification system
EN12_08605	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
EN12_08610	ENOG4108MX5	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)
EN12_08615	ENOG4105QEK	Transcriptional regulator
EN12_08625	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EN12_08630	ENOG41069H7	transport system small permease component
EN12_08635	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
EN12_08640	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
EN12_08645	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
EN12_08650	ENOG4105CE4	GlcNAc 6-P deacetylase
EN12_08655	ENOG4108478	ec 3.2.1.18
EN12_08665	ENOG4108YGG	dna repair protein
EN12_08690	ENOG4108NYK	Tape measure protein
EN12_08810	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
EN12_08820	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
EN12_08825	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
EN12_08830	ENOG4105C26	Dehydrogenase
EN12_08840	ENOG4105DM4	PTS System
EN12_08845	ENOG4105DM4	PTS System
EN12_08850	ENOG4108YRF	PTS System
EN12_08860	ENOG4106R3P	AraC family transcriptional regulator
EN12_08865	ENOG4105DM4	PTS System
EN12_08870	ENOG4105EIP	mannose-6-phosphate isomerase
EN12_08875	ENOG4108RNS	Exports L-alanine (By similarity)
EN12_08880	ENOG4105BZU	Histidine kinase
EN12_08890	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
EN12_08900	ENOG4105KCK	Peptidoglycan-associated lipoprotein
EN12_08905	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
EN12_08915	ENOG4105M8F	Biopolymer transport protein exbD tolR
EN12_08920	ENOG4105E02	MotA TolQ exbB proton channel
EN12_08925	ENOG4107YD3	Thioesterase
EN12_08930	ENOG4105KJB	cyd operon protein YbgE
EN12_08940	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
EN12_08945	ENOG4105C4M	(Ubiquinol oxidase) subunit I
EN12_08950	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
EN12_08955	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
EN12_08960	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
EN12_08965	ENOG4105C8N	cysteinyl-tRNA synthetase
EN12_08970	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
EN12_08975	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
EN12_08980	ENOG4105D58	Diguanylate phosphodiesterase
EN12_08995	ENOG4105ZU8	porin-like protein H
EN12_09000	ENOG4105DVT	helicase
EN12_09005	ENOG4105EJ9	Membrane
EN12_09010	ENOG4108URS	primosomal replication protein n''
EN12_09015	ENOG4106428	Protein of unknown function (DUF2496)
EN12_09020	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_09025	ENOG4105CGK	Exodeoxyribonuclease III
EN12_09030	ENOG4106YG3	ABC transporter
EN12_09035	ENOG4105DSP	amino acid AbC transporter
EN12_09040	ENOG4105E89	ABC transporter
EN12_09045	ENOG4108JEH	abc transporter atp-binding protein
EN12_09060	ENOG4105C6N	Formate acetyltransferase
EN12_09070	ENOG4108N3W	hemolysin secretion protein
EN12_09075	ENOG4105F1A	Pyruvate formate-lyase
EN12_09085	ENOG4105XWI	UPF0304 protein
EN12_09090	ENOG4105CYN	Serine protein kinase
EN12_09095	ENOG4106AKX	UPF0229 protein
EN12_09100	ENOG4105ED1	spovr family
EN12_09105	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
EN12_09115	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
EN12_09120	ENOG4105BZ1	(ABC) transporter
EN12_09125	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
EN12_09135	ENOG4105D60	lipoprotein releasing system transmembrane protein
EN12_09140	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EN12_09145	ENOG4105D60	lipoprotein releasing system transmembrane protein
EN12_09155	ENOG4108JA2	transcriptioN-repair coupling factor
EN12_09165	ENOG4106M3D	hemolysin
EN12_09175	ENOG4105CEP	NADH dehydrogenase
EN12_09205	ENOG4105K59	histidine triad (HIT) protein
EN12_09210	ENOG4108NVR	Methyl-accepting chemotaxis
EN12_09220	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
EN12_09225	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
EN12_09230	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
EN12_09235	ENOG4105CNU	cell division protein FtsK
EN12_09240	ENOG4105EW9	transcriptional regulator AsnC family
EN12_09245	ENOG4105DCF	alanine dehydrogenase
EN12_09255	ENOG4107R11	Transcriptional regulator
EN12_09270	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
EN12_09275	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
EN12_09280	ENOG4105CFV	Tetratricopeptide repeat protein
EN12_09285	ENOG4105Q4A	inner membrane protein yciS
EN12_09290	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
EN12_09295	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
EN12_09300	ENOG4105CAT	Cytidine monophosphate kinase
EN12_09305	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
EN12_09310	ENOG4105EIN	peptidylprolyl cis-trans isomerase
EN12_09315	ENOG4105K70	DNA-binding protein
EN12_09320	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EN12_09325	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
EN12_09330	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EN12_09335	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
EN12_09350	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_09355	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EN12_09360	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
EN12_09365	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
EN12_09370	ENOG4105CNG	UPF0061 protein
EN12_09385	ENOG4105BZU	Histidine kinase
EN12_09395	ENOG4108HPI	phosphatidate Cytidylyltransferase
EN12_09430	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
EN12_09450	ENOG4105JQN	Transcriptional regulator
EN12_09460	ENOG4107QY8	reductase
EN12_09465	ENOG4105CUW	cytochrome C-TYPE protein
EN12_09470	ENOG410662T	chitinase
EN12_09475	ENOG4105D9N	nucleoside
EN12_09485	ENOG4105JQN	Transcriptional regulator
EN12_09490	ENOG4105CVE	Lytic murein transglycosylase
EN12_09495	ENOG4105VNG	YcgL domain-containing protein
EN12_09500	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
EN12_09505	ENOG4107QMS	site-determining protein
EN12_09510	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
EN12_09535	ENOG4107S74	Lysophospholipid transporter LplT
EN12_09545	ENOG4108N3W	hemolysin secretion protein
EN12_09550	ENOG4108JCI	Transcriptional regulator
EN12_09555	ENOG4105DKK	Benzoate
EN12_09560	ENOG4105CEY	Amp-dependent synthetase and ligase
EN12_09565	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
EN12_09570	ENOG4108IPT	Naphthoate synthase
EN12_09575	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
EN12_09580	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
EN12_09585	ENOG4105E4F	Isochorismate synthase
EN12_09590	ENOG4105CHM	Aminotransferase
EN12_09595	ENOG4105DK2	UPF0207 protein
EN12_09600	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
EN12_09620	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
EN12_09625	ENOG4105CEY	Amp-dependent synthetase and ligase
EN12_09630	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
EN12_09645	ENOG41072GX	Peptidase M22 Glycoprotease
EN12_09650	ENOG4105DVT	helicase
EN12_09660	ENOG4105CIY	formyltetrahydrofolate deformylase
EN12_09665	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
EN12_09670	ENOG4105D07	Signal peptide peptidase, SppA
EN12_09675	ENOG4105HDK	L-asparaginase
EN12_09680	ENOG4105VUT	cytoplasmic protein
EN12_09690	ENOG4105E0X	reductase
EN12_09695	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EN12_09700	ENOG4105DSB	aldose 1-epimerase
EN12_09710	ENOG4105DHI	Methyltransferase
EN12_09725	ENOG4107R88	Chemotaxis protein (CheV)
EN12_09730	ENOG4105DAG	ROK family
EN12_09735	ENOG4105CA9	Pyruvate kinase
EN12_09740	ENOG4108NRW	Phospholipase, patatin family
EN12_09755	ENOG4105C8J	)-transporter
EN12_09765	ENOG4105CI1	PTS System
EN12_09770	ENOG4105F8V	Hydrolase, tatD family
EN12_09775	ENOG4107QRG	dna polymerase iii
EN12_09780	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
EN12_09785	ENOG4105HHA	aminodeoxychorismate lyase
EN12_09790	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
EN12_09795	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
EN12_09800	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
EN12_09805	ENOG4105CHR	reductase
EN12_09810	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
EN12_09815	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EN12_09820	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
EN12_09825	ENOG4105VGS	50s ribosomal protein l32
EN12_09830	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
EN12_09835	ENOG4108UHJ	MAF-like protein
EN12_09840	ENOG4105EI2	Pseudouridine synthase
EN12_09850	ENOG4105C03	ribonuclease
EN12_09855	ENOG4105CHH	sulfate transporter
EN12_09865	ENOG4108EKI	Dehydrogenase
EN12_09870	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
EN12_09875	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
EN12_09880	ENOG4105DFD	Na H antiporter
EN12_09890	ENOG4106V8H	Nucleoid-associated protein
EN12_09900	ENOG4105E68	Sulfatase
EN12_09920	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
EN12_09925	ENOG4105M2J	Glutaredoxin
EN12_09930	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
EN12_09945	ENOG410903C	(LipO)protein
EN12_09955	ENOG4105KWW	Biogenesis protein
EN12_09960	ENOG4107QX9	Thiol disulfide interChange protein
EN12_09965	ENOG4105DA4	cytochrome c-type biogenesis protein
EN12_09970	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
EN12_09975	ENOG41067VX	Heme exporter protein
EN12_09980	ENOG41060IM	Heme exporter protein
EN12_09985	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
EN12_09990	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
EN12_10000	ENOG4108V3W	Chemotaxis protein, CheW
EN12_10010	ENOG4107QJE	Chromosome Partitioning Protein
EN12_10015	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
EN12_10020	ENOG4105CBS	Chea signal transduction histidine kinase
EN12_10025	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
EN12_10030	ENOG4108VYJ	response regulator receiver protein
EN12_10035	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EN12_10040	ENOG4107R21	site-determining protein
EN12_10045	ENOG4105FZW	flagellar biosynthesis regulator FlhF
EN12_10050	ENOG4105D7B	Flagellar biosynthesis protein flha
EN12_10055	ENOG4108BY2	phosphohistidine phosphatase
EN12_10060	ENOG4108JQM	Insulinase (Peptidase family M16)
EN12_10070	ENOG4105C75	arginyL-tRNA synthetase
EN12_10090	ENOG4105XFK	Ferrous iron transport protein A
EN12_10095	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
EN12_10100	ENOG4105NXV	High-affinity zinc uptake system protein
EN12_10105	ENOG4105FDK	ABC transporter
EN12_10110	ENOG4105FAV	ABC, transporter
EN12_10115	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
EN12_10120	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
EN12_10125	ENOG4105C7S	Dehydrogenase
EN12_10130	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
EN12_10135	ENOG4105E33	succinate dehydrogenase
EN12_10140	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
EN12_10145	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
EN12_10150	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
EN12_10155	ENOG4105BZN	citrate synthase
EN12_10160	ENOG4107QNR	UPF0135 protein
EN12_10170	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
EN12_10175	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
EN12_10180	ENOG4105EV9	Alpha Beta Hydrolase
EN12_10190	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
EN12_10195	ENOG41067MG	lrgb family
EN12_10200	ENOG4105VAW	lrga family
EN12_10205	ENOG4105CMU	LysR family (Transcriptional regulator
EN12_10215	ENOG41090R7	Ferric uptake
EN12_10220	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
EN12_10225	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
EN12_10230	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
EN12_10235	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
EN12_10240	ENOG4105Q8W	reductase
EN12_10245	ENOG4105MH2	YfcL protein
EN12_10250	ENOG4108BPE	-transporting atpase
EN12_10255	ENOG4105EN6	Membrane
EN12_10260	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
EN12_10265	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
EN12_10275	ENOG4105D00	flagellar biosynthetic protein flhB
EN12_10280	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
EN12_10285	ENOG4105VS8	Flagellar biosynthetic protein fliq
EN12_10290	ENOG4105CN7	Flagellar biosynthetic protein FliP
EN12_10295	ENOG4105VTB	flagellar biosynthesis protein fliO
EN12_10300	ENOG4105DD5	Flagellar motor switch protein
EN12_10305	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
EN12_10310	ENOG4105X6C	Flagellar basal body-associated protein FliL
EN12_10325	ENOG4108JIR	Flagellum-specific ATP synthase
EN12_10330	ENOG4105W2B	Flagellar assembly protein
EN12_10335	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
EN12_10340	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
EN12_10345	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
EN12_10350	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_10355	ENOG4105BZU	Histidine kinase
EN12_10360	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_10365	ENOG4105MQ3	flagellar protein FliS
EN12_10375	ENOG4107W9T	flagellar hook-associated
EN12_10380	ENOG41063QE	flagellar protein FlaG
EN12_10385	ENOG4105I03	Flagellin
EN12_10390	ENOG4105I03	Flagellin
EN12_10395	ENOG4105I03	Flagellin
EN12_10400	ENOG4105EZR	dyp-type peroxidase family protein
EN12_10405	ENOG4105QZU	Inner membrane protein YfeZ
EN12_10420	ENOG4105KUZ	arsenate reductase
EN12_10425	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
EN12_10440	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
EN12_10445	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
EN12_10455	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EN12_10460	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_10475	ENOG4105ERG	peptidase m48, ste24p
EN12_10480	ENOG4105K89	arsenate reductase
EN12_10485	ENOG4105CS1	NAD(P)H quinone oxidoreductase
EN12_10500	ENOG4105C2W	permease
EN12_10505	ENOG4108Z66	YbaK ebsC protein
EN12_10510	ENOG4105CGH	5'-nucleotidase
EN12_10515	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
EN12_10520	ENOG41063JG	Transcriptional regulator
EN12_10525	ENOG4108YY7	Invasion gene expression up-regulator SirB
EN12_10530	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
EN12_10535	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
EN12_10540	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
EN12_10545	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
EN12_10550	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
EN12_10555	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
EN12_10560	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
EN12_10565	ENOG4105C3G	gtp-binding protein
EN12_10650	ENOG4105I03	Flagellin
EN12_10655	ENOG4105I03	Flagellin
EN12_10670	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
EN12_10675	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
EN12_10680	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
EN12_10685	ENOG4105CGA	flagellar basal-body rod protein FlgG
EN12_10690	ENOG4108KPB	Flagellar basal-body rod protein FlgF
EN12_10695	ENOG4105BZE	flagellar hook protein, FlgE
EN12_10700	ENOG4105W00	Flagellar hook capping protein
EN12_10705	ENOG4108ZC9	flagellar basal-body rod protein flgc
EN12_10710	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
EN12_10715	ENOG4105BZU	Histidine kinase
EN12_10720	ENOG4107R88	Chemotaxis protein (CheV)
EN12_10755	ENOG4105C0W	non-ribosomal peptide synthetase
EN12_10760	ENOG4105Q26	Siderophore-interacting protein
EN12_10765	ENOG4107RBR	Receptor
EN12_10775	ENOG4105UYK	outer membrane protein a
EN12_10780	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
EN12_10785	ENOG4105C59	p-type ATPase
EN12_10795	ENOG4105E2D	ec 3.2.1.52
EN12_10800	ENOG4105MBR	gumn family
EN12_10815	ENOG4108DG9	Smr protein MutS2
EN12_10820	ENOG4105FE9	pseudouridine synthase
EN12_10825	ENOG4105BZU	Histidine kinase
EN12_10830	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
EN12_10835	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
EN12_10840	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
EN12_10845	ENOG4105E7A	Glutamine amidotransferase
EN12_10850	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
EN12_10855	ENOG4107QPN	acyl-Coa dehydrogenase
EN12_10865	ENOG4108JDX	DNA polymerase iii, epsilon subunit
EN12_10870	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EN12_10875	ENOG4105D1A	Methyltransferase
EN12_10880	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
EN12_10885	ENOG4105E9H	Lytic Murein transglycosylase
EN12_10895	ENOG4108YZA	Nitrogen regulatory protein pii
EN12_10900	ENOG4105PY6	Phenolic acid decarboxylase
EN12_10905	ENOG4105N7H	Cytochrome
EN12_10910	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
EN12_10915	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
EN12_10920	ENOG4105C0B	DNA polymerase III (alpha subunit)
EN12_10925	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EN12_10930	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EN12_10935	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EN12_10940	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
EN12_10945	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EN12_10950	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
EN12_10960	ENOG4105DZP	Membrane-associated zinc metalloprotease
EN12_10965	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
EN12_10970	ENOG4105KNE	Phosphatidate cytidylyltransferase
EN12_10975	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
EN12_10980	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
EN12_10985	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
EN12_10990	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
EN12_10995	ENOG4105CE9	30S ribosomal protein S2
EN12_11000	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
EN12_11005	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
EN12_11010	ENOG4108T8E	UPF0325 protein
EN12_11015	ENOG4108ZAI	phosphatidylglycerophosphatase a
EN12_11020	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
EN12_11025	ENOG4107YIM	Involved in the transcription termination process (By similarity)
EN12_11030	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
EN12_11045	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
EN12_11050	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
EN12_11055	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
EN12_11060	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
EN12_11065	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
EN12_11075	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
EN12_11080	ENOG4105C7N	Xanthine uracil vitamin C permease
EN12_11085	ENOG4105CIN	aminoacyl-histidine dipeptidase
EN12_11090	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
EN12_11095	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
EN12_11105	ENOG4105C8J	)-transporter
EN12_11110	ENOG4105BZU	Histidine kinase
EN12_11135	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EN12_11145	ENOG4105CJ2	(LipO)protein
EN12_11150	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
EN12_11155	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
EN12_11160	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
EN12_11165	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
EN12_11170	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
EN12_11175	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
EN12_11180	ENOG4105M85	Bola protein
EN12_11185	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
EN12_11195	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
EN12_11200	ENOG4105EYM	Major Facilitator superfamily
EN12_11210	ENOG4105K6V	RNA polymerase
EN12_11220	ENOG4105DRB	nucleoside-specific channel-forming protein
EN12_11225	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
EN12_11230	ENOG4107S0N	DJ-1 family
EN12_11235	ENOG4105C9B	Cysteine desulfurase
EN12_11240	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
EN12_11245	ENOG4105CUZ	uba thif-type nad fad binding protein
EN12_11250	ENOG4105CA3	membrane-bound lytic murein transglycosylase
EN12_11260	ENOG4107QZM	n-acetylglutamate synthase
EN12_11275	ENOG4107QYX	exodeoxyribonuclease v alpha
EN12_11280	ENOG4107QKA	exodeoxyribonuclease V beta
EN12_11285	ENOG4105DSY	exodeoxyribonuclease V, gamma
EN12_11300	ENOG4105X2V	dna damage-inducible protein
EN12_11305	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
EN12_11315	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
EN12_11325	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
EN12_11340	ENOG4108Y51	tRNA-binding protein
EN12_11345	ENOG41060NJ	transcriptional regulator
EN12_11350	ENOG4105CNT	hydrolase family 2
EN12_11360	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EN12_11365	ENOG4108IQE	Amp-dependent synthetase and ligase
EN12_11370	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
EN12_11375	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
EN12_11385	ENOG4105EAC	phosphoserine phosphatase
EN12_11395	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
EN12_11400	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
EN12_11405	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
EN12_11410	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
EN12_11415	ENOG4105D9N	nucleoside
EN12_11420	ENOG4105EYA	deoxyribonuclease
EN12_11430	ENOG4105BZG	amino acid carrier protein
EN12_11445	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
EN12_11450	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
EN12_11455	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
EN12_11460	ENOG4105D98	threonine synthase
EN12_11465	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
EN12_11480	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
EN12_11490	ENOG41065U4	response regulator
EN12_11495	ENOG4105BZU	Histidine kinase
EN12_11505	ENOG4105N5T	Radical SAM Protein
EN12_11520	ENOG4105CBC	glutamate synthase
EN12_11525	ENOG4105BZ8	glutamate synthase
EN12_11535	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
EN12_11545	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
EN12_11550	ENOG4105EN6	Membrane
EN12_11555	ENOG4105VP0	transcriptional regulator, lysR family
EN12_11560	ENOG4105EJ9	Membrane
EN12_11565	ENOG4107RRE	RNA-directed DNA polymerase
EN12_11590	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EN12_11595	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
EN12_11605	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
EN12_11610	ENOG4105M6F	mutator MutT protein
EN12_11615	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EN12_11625	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EN12_11630	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
EN12_11635	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
EN12_11640	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
EN12_11645	ENOG4105DFU	Cell wall formation (By similarity)
EN12_11650	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
EN12_11660	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
EN12_11665	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
EN12_11670	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
EN12_11675	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
EN12_11680	ENOG4105CJN	penicillin-binding protein
EN12_11685	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
EN12_11690	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
EN12_11695	ENOG4107QN2	dihydrolipoyl dehydrogenase
EN12_11700	ENOG4107QSN	dihydrolipoamide acetyltransferase
EN12_11705	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
EN12_11710	ENOG41073TP	transcriptional regulator
EN12_11715	ENOG4105CGH	5'-nucleotidase
EN12_11720	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
EN12_11725	ENOG4105T95	Thiol disulfide interChange protein
EN12_11730	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EN12_11735	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
EN12_11745	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
EN12_11755	ENOG4107QHF	type ii secretion system protein e
EN12_11760	ENOG4105D7Q	type ii secretion system
EN12_11765	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
EN12_11770	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
EN12_11775	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
EN12_11785	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
EN12_11790	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EN12_11795	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EN12_11800	ENOG4105IPS	esterase
EN12_11805	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
EN12_11810	ENOG4108SX3	cytoplasmic protein
EN12_11815	ENOG41087AY	ADP-Ribose pyrophosphatase
EN12_11820	ENOG4105DFG	type I secretion outer membrane protein
EN12_11830	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
EN12_11835	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_11845	ENOG4105I7R	Adenylate cyclase
EN12_11850	ENOG4107IX6	phosphate transport regulator
EN12_11855	ENOG4105CJ3	phosphate transporter
EN12_11860	ENOG4106MWK	domain protein
EN12_11875	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
EN12_11880	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
EN12_11885	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
EN12_11890	ENOG4105DXN	mazG family
EN12_11895	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
EN12_11900	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EN12_11905	ENOG4105BZU	Histidine kinase
EN12_11910	ENOG4108K0B	C-di-gmp phosphodiesterase
EN12_11925	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
EN12_11930	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
EN12_11935	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
EN12_11940	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
EN12_11945	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
EN12_11950	ENOG4105C3F	Signal peptidase i
EN12_11955	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
EN12_11960	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
EN12_11965	ENOG4105VQK	sigma E regulatory protein, MucB RseB
EN12_11975	ENOG4105EMN	RNA polymerase sigma factor
EN12_11980	ENOG4108IYU	L-aspartate oxidase
EN12_11990	ENOG4105Y75	tpr repeat protein
EN12_11995	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
EN12_12005	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
EN12_12010	ENOG4105D0A	hydroxylase
EN12_12020	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
EN12_12025	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
EN12_12030	ENOG4105E66	phosphoriboisomerase A
EN12_12035	ENOG4108JQ1	Dehydrogenase
EN12_12040	ENOG4108ZP8	Acetolactate synthase small subunit
EN12_12045	ENOG4105C7K	acetolactate synthase
EN12_12050	ENOG4108IQE	Amp-dependent synthetase and ligase
EN12_12055	ENOG41064T2	transcriptional regulator, lysR family
EN12_12075	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
EN12_12080	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
EN12_12085	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EN12_12090	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EN12_12135	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EN12_12150	ENOG4108K5H	permease YjgP YjgQ family protein
EN12_12155	ENOG4108M8S	permease YjgP YjgQ family protein
EN12_12160	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
EN12_12165	ENOG4105MYG	DNA polymerase iii, chi subunit
EN12_12170	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
EN12_12175	ENOG4105C5I	Dehydrogenase
EN12_12180	ENOG4105D3G	Pseudouridine synthase
EN12_12185	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
EN12_12195	ENOG4108IAB	Phoh family
EN12_12200	ENOG4105DBV	ornithine carbamoyltransferase
EN12_12210	ENOG4105CXT	aspartate transcarbamylase
EN12_12215	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
EN12_12220	ENOG4105KME	endoribonuclease L-psp
EN12_12225	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
EN12_12230	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
EN12_12235	ENOG4105VFK	BolA family
EN12_12245	ENOG4105E3I	toluene tolerance
EN12_12250	ENOG4107PE3	Mammalian cell entry related domain protein
EN12_12255	ENOG4105CY3	ABC transporter, permease
EN12_12260	ENOG4105DHJ	ABC, transporter
EN12_12270	ENOG4105C2X	Arabinose 5-phosphate isomerase
EN12_12275	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
EN12_12285	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
EN12_12290	ENOG4108IUZ	ABC transporter
EN12_12295	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EN12_12300	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
EN12_12305	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
EN12_12310	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
EN12_12315	ENOG41080Z8	PHOSPHOCARRIER protein
EN12_12320	ENOG4105CJW	magnesium transporter
EN12_12325	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
EN12_12330	ENOG4105N42	UPF0307 protein
EN12_12335	ENOG4107T0D	ABC, transporter
EN12_12340	ENOG4106SMU	thiamine transporter membrane protein
EN12_12345	ENOG4105DP9	ABC transporter
EN12_12350	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
EN12_12355	ENOG4105DFU	Cell wall formation (By similarity)
EN12_12360	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EN12_12365	ENOG4105F0N	pyrophosphate phospho-hydrolase
EN12_12370	ENOG41066HZ	AIG2-like family
EN12_12380	ENOG4105CFU	surface antigen
EN12_12385	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
EN12_12390	ENOG4108UUE	Transcriptional regulator
EN12_12405	ENOG4105C19	ABC transporter
EN12_12425	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
EN12_12430	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
EN12_12435	ENOG4105C11	sulfate adenylyltransferase), subunit 2
EN12_12440	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
EN12_12445	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
EN12_12455	ENOG4105C1J	atp-dependent rna helicase
EN12_12460	ENOG4107YB6	acetyltransferase, (GNAT) family
EN12_12465	ENOG4108SXK	Transporter Drug Metabolite Exporter family
EN12_12470	ENOG4108UBT	opacity-associated protein
EN12_12475	ENOG4108V1T	peptidylprolyl cis-trans isomerase
EN12_12485	ENOG4108ZT0	50S ribosomal protein l17
EN12_12490	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EN12_12495	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
EN12_12500	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
EN12_12505	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EN12_12515	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
EN12_12520	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
EN12_12525	ENOG4105VPB	50S ribosomal protein L30
EN12_12530	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
EN12_12535	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
EN12_12540	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
EN12_12545	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
EN12_12550	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
EN12_12555	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EN12_12560	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
EN12_12565	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
EN12_12570	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
EN12_12575	ENOG41083MP	50s ribosomal protein l29
EN12_12580	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
EN12_12585	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
EN12_12590	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
EN12_12595	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
EN12_12600	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EN12_12605	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
EN12_12610	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
EN12_12615	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
EN12_12620	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
EN12_12625	ENOG4105C2N	RNA methyltransferase TrmH family group 3
EN12_12630	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
EN12_12635	ENOG4105E68	Sulfatase
EN12_12640	ENOG4108UV7	flagellar protein motX
EN12_12645	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
EN12_12650	ENOG4105D44	asparaginase
EN12_12655	ENOG4108YZY	peptidylprolyl cis-trans isomerase
EN12_12670	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
EN12_12675	ENOG4105C5H	ABC transporter
EN12_12685	ENOG4105DNZ	Alpha Beta Hydrolase
EN12_12695	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
EN12_12700	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
EN12_12710	ENOG4105C26	Dehydrogenase
EN12_12720	ENOG4105C8Y	Acetylornithine aminotransferase
EN12_12725	ENOG4105DDQ	anthranilate synthase
EN12_12730	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
EN12_12745	ENOG4105C31	Tryptophanyl-tRNA synthetase
EN12_12750	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EN12_12755	ENOG4105DJV	ribulose-phosphate 3-epimerase
EN12_12760	ENOG4105DFE	Dna adenine methylase
EN12_12770	ENOG4105D49	3-dehydroquinate synthase
EN12_12775	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
EN12_12780	ENOG4105E4G	Type IV pilus
EN12_12805	ENOG4108JQC	penicillin-binding protein 1A
EN12_12815	ENOG4105EHV	domain protein
EN12_12820	ENOG4107QN2	dihydrolipoyl dehydrogenase
EN12_12830	ENOG4105CH7	arginosuccinase
EN12_12835	ENOG4105CDH	Citrulline--aspartate ligase
EN12_12840	ENOG4105CAS	nag kinase
EN12_12845	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
EN12_12850	ENOG4105CWC	Acetylornithine deacetylase
EN12_12855	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
EN12_12865	ENOG4105D7W	serine acetyltransferase
EN12_12870	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
EN12_12875	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
EN12_12880	ENOG4107YZP	Rhodanese domain protein
EN12_12885	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
EN12_12895	ENOG4105E33	succinate dehydrogenase
EN12_12900	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
EN12_12905	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
EN12_12910	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
EN12_12915	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
EN12_12925	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EN12_12930	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EN12_12955	ENOG4105CP7	Triose-phosphate isomerase
EN12_12965	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
EN12_12970	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
EN12_12975	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
EN12_12980	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
EN12_12985	ENOG41063M6	Cell Division Protein
EN12_12990	ENOG4105ETE	Transcriptional regulator (LacI family
EN12_12995	ENOG4105C25	Primosomal protein n'
EN12_13000	ENOG4105VFB	Binds the 23S rRNA (By similarity)
EN12_13005	ENOG4105C6K	Malic enzyme
EN12_13010	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
EN12_13015	ENOG4105C28	cystathionine
EN12_13020	ENOG4105CFH	Aspartokinase
EN12_13030	ENOG4105SYT	Methylenetetrahydrofolate reductase
EN12_13035	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
EN12_13040	ENOG4105CBT	Fructose-1,6-bisphosphatase
EN12_13045	ENOG4105CTQ	phosphohexokinase
EN12_13050	ENOG41076HS	cation diffusion facilitator family transporter
EN12_13060	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
EN12_13065	ENOG4105E0F	Histidine kinase
EN12_13075	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
EN12_13080	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
EN12_13085	ENOG4105BZU	Histidine kinase
EN12_13090	ENOG4108IJ0	Aspartate ammonia-lyase
EN12_13095	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
EN12_13110	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
EN12_13120	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
EN12_13130	ENOG4107QN1	sodium solute
EN12_13135	ENOG4105EX9	Membrane
EN12_13140	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EN12_13145	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
EN12_13150	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
EN12_13155	ENOG4105CB5	ATP-dependent DNA helicase recG
EN12_13160	ENOG4105C2W	permease
EN12_13165	ENOG4105E0F	Histidine kinase
EN12_13170	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EN12_13175	ENOG4108RRZ	Transcription elongation factor GreB
EN12_13180	ENOG4105BZM	domain protein
EN12_13190	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
EN12_13195	ENOG4105MJ2	Competence protein
EN12_13200	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
EN12_13205	ENOG4107RK2	ADP-ribose diphosphatase NudE
EN12_13210	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
EN12_13215	ENOG4105PIC	general secretion pathway protein N
EN12_13220	ENOG4105U1E	general secretion pathway protein M
EN12_13225	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
EN12_13230	ENOG4108RTD	type II secretion system protein K
EN12_13235	ENOG4108WWZ	General secretion pathway protein J
EN12_13240	ENOG4105X5Z	General secretion pathway protein I
EN12_13245	ENOG4105VWV	general secretion pathway protein h
EN12_13250	ENOG4108VAU	general secretion pathway protein G
EN12_13255	ENOG4105D7Q	type ii secretion system
EN12_13260	ENOG4107QHF	type ii secretion system protein e
EN12_13270	ENOG4108XKW	General secretion pathway protein C
EN12_13275	ENOG4105VEJ	Heat shock protein
EN12_13280	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
EN12_13285	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
EN12_13295	ENOG4105SUU	thioesterase domain
EN12_13300	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
EN12_13325	ENOG4105C5F	glutamine synthetase
EN12_13340	ENOG4105CUX	Signal transduction histidine kinase
EN12_13345	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_13350	ENOG4105BZU	Histidine kinase
EN12_13355	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
EN12_13390	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
EN12_13395	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
EN12_13400	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
EN12_13405	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
EN12_13420	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
EN12_13425	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EN12_13430	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
EN12_13435	ENOG4105CAK	Cell division ATP-binding protein ftsE
EN12_13440	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
EN12_13445	ENOG4106H78	methyltransferase
EN12_13480	ENOG4108RMU	ferritin dps family protein
EN12_13485	ENOG4105D58	Diguanylate phosphodiesterase
EN12_13490	ENOG410829K	Lysine exporter protein (Lyse ygga)
EN12_13495	ENOG4108EUD	Lysophospholipase
EN12_13500	ENOG4105DQF	Hydrolase
EN12_13515	ENOG4105BZU	Histidine kinase
EN12_13520	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
EN12_13525	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EN12_13530	ENOG4105CT0	Protein of unknown function, DUF484
EN12_13535	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
EN12_13540	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
EN12_13550	ENOG4105XQ6	frataxin-like protein
EN12_13555	ENOG4107T0K	Adenylate cyclase
EN12_13565	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
EN12_13570	ENOG41076E6	Uroporphyrinogen-III Synthase
EN12_13575	ENOG4105ECF	c-methyltransferase
EN12_13580	ENOG410601J	HemY protein
EN12_13585	ENOG4105D4P	Coproporphyrinogen iii oxidase
EN12_13590	ENOG4105XCT	Protein of unknown function (DUF2489)
EN12_13595	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
EN12_13605	ENOG4106RE7	Cytochrome
EN12_13610	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
EN12_13615	ENOG4105C2M	dna polymerase I
EN12_13625	ENOG4105D52	delta-aminolevulinic acid dehydratase
EN12_13630	ENOG4105F8V	Hydrolase, tatD family
EN12_13635	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
EN12_13645	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_13650	ENOG4105X6C	Flagellar basal body-associated protein FliL
EN12_13655	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
EN12_13660	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
EN12_13665	ENOG4105E55	glycerol-3-phosphate acyltransferase
EN12_13670	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
EN12_13680	ENOG4107R73	Mate efflux family protein
EN12_13685	ENOG4105CA0	peroxidase
EN12_13690	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
EN12_13695	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
EN12_13700	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
EN12_13705	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
EN12_13710	ENOG4105JC1	sterol-binding domain protein
EN12_13715	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
EN12_13720	ENOG4105CGY	Dna recombination protein
EN12_13730	ENOG4105CBX	hi0933 family
EN12_13735	ENOG4108V6B	universal stress protein B
EN12_13740	ENOG41090A1	ferritin
EN12_13745	ENOG4108M6U	Universal stress protein A
EN12_13750	ENOG4105EMK	carboxylate amino acid amine transporter
EN12_13760	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
EN12_13765	ENOG4105BZU	Histidine kinase
EN12_13770	ENOG4108VVK	transcriptional Regulator, AsnC
EN12_13780	ENOG4105CNH	Multidrug resistance protein MdtL
EN12_13790	ENOG4105DC7	peptidase M24
EN12_13790	ENOG4105DC7	peptidase M24
EN12_13795	ENOG4105D41	biosynthesis protein thiH
EN12_13800	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
EN12_13805	ENOG4105WHD	thiamine biosynthesis protein ThiS
EN12_13810	ENOG4105D06	uba thif-type nad fad binding protein
EN12_13820	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
EN12_13825	ENOG4105WMR	Protein CrcB homolog
EN12_13865	ENOG4108Z0R	Transferase
EN12_13875	ENOG4105E2X	shikimate dehydrogenase
EN12_13880	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
EN12_13885	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EN12_13890	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
EN12_13895	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
EN12_13900	ENOG4108WI1	Dna topoisomerase
EN12_13905	ENOG4108RPN	Protein smg homolog
EN12_13910	ENOG4105C79	DNA protecting protein DprA
EN12_13915	ENOG4108WZM	domain protein
EN12_13920	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EN12_13925	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
EN12_13930	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
EN12_13935	ENOG4105C1A	potassium transporter peripheral membrane
EN12_13940	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
EN12_13950	ENOG4108UT2	hemolysin iii
EN12_13955	ENOG4108N23	SpoOM-related protein
EN12_13965	ENOG4105PC1	Conserved Protein
EN12_13975	ENOG4105E27	serine threonine protein kinase
EN12_13980	ENOG4108Z33	Thiol disulfide Interchange Protein
EN12_13985	ENOG4106HNH	Acyl-transferase
EN12_13990	ENOG4105C0P	Mg chelatase subunit ChlI
EN12_14005	ENOG4105CM2	brancheD-chain amino acid aminotransferase
EN12_14010	ENOG4105C01	Dihydroxy-acid dehydratase
EN12_14015	ENOG4105C7B	Threonine dehydratase
EN12_14020	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
EN12_14030	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
EN12_14045	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
EN12_14050	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
EN12_14055	ENOG4105JKW	Valine--pyruvate aminotransferase
EN12_14060	ENOG4108ZNX	Heat shock protein
EN12_14075	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EN12_14080	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
EN12_14085	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
EN12_14090	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EN12_14125	ENOG4105CDY	transcriptional regulatory protein
EN12_14130	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
EN12_14135	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_14140	ENOG4108YYI	Protein of unknown function (DUF2810)
EN12_14145	ENOG41061ZR	Transcriptional regulator
EN12_14150	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
EN12_14155	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
EN12_14160	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
EN12_14165	ENOG4108WC9	type VI secretion system effector, hcp1 family
EN12_14170	ENOG4105CS6	Rhs element vgr protein
EN12_14195	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EN12_14205	ENOG4105C8P	)-transporter
EN12_14210	ENOG4108Q67	UPF0319 protein
EN12_14235	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_14255	ENOG4105EYK	Phosphatidylglycerophosphatase B
EN12_14260	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
EN12_14285	ENOG4105D6U	Sodium Glutamate Symporter
EN12_14290	ENOG4105YE1	PilZ domain
EN12_14305	ENOG4105EFX	secretion protein, HlyD family
EN12_14310	ENOG4105KK7	inner membrane protein YiaW
EN12_14315	ENOG4106TD9	Diguanylate cyclase
EN12_14330	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
EN12_14335	ENOG4107SEY	Conserved Protein
EN12_14345	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
EN12_14350	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
EN12_14360	ENOG4105C1J	atp-dependent rna helicase
EN12_14365	ENOG4105CUG	Oligopeptidase b
EN12_14395	ENOG4105CVA	phosphate
EN12_14400	ENOG4105C8U	phosphate abc transporter
EN12_14405	ENOG4105E2Z	phosphate ABC transporter (Permease
EN12_14410	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EN12_14415	ENOG4105BZU	Histidine kinase
EN12_14425	ENOG4105DWD	nucleoside recognition domain protein
EN12_14430	ENOG4105CHH	sulfate transporter
EN12_14440	ENOG4105DR5	peptidase
EN12_14445	ENOG4105BZU	Histidine kinase
EN12_14450	ENOG4105EQ2	LysR family Transcriptional regulator
EN12_14455	ENOG4105E5M	Multidrug resistance protein D
EN12_14460	ENOG4108Z4X	TRANSCRIPTIONal
EN12_14480	ENOG4105CK2	sodium dicarboxylate symporter
EN12_14525	ENOG4107RH7	Nicotinate phosphoribosyltransferase
EN12_14530	ENOG4105D9R	oxidoreductase
EN12_14540	ENOG4105BZU	Histidine kinase
EN12_14545	ENOG4107VXZ	Hydrolase
EN12_14555	ENOG4105D3G	Pseudouridine synthase
EN12_14615	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EN12_14620	ENOG4108JUB	Transcriptional regulator
EN12_14645	ENOG4105CS6	Rhs element vgr protein
EN12_14660	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
EN12_14665	ENOG4105C2J	ABC transporter
EN12_14670	ENOG4105CNN	ABC, transporter
EN12_14675	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
EN12_14680	ENOG4108RVA	ribokinase
EN12_14685	ENOG4105ETE	Transcriptional regulator (LacI family
EN12_14690	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
EN12_14695	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
EN12_14700	ENOG4108I5U	Uridine phosphorylase
EN12_14710	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
EN12_14715	ENOG4105CXY	transporter
EN12_14730	ENOG4105CQZ	Histidine kinase
EN12_14735	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EN12_14755	ENOG4105D5U	fad dependent oxidoreductase
EN12_14765	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EN12_14775	ENOG4105KJM	monovalent cation h antiporter subunit g
EN12_14780	ENOG41080TA	Multiple resistance and ph regulation protein f
EN12_14785	ENOG4105SC1	monovalent cation H antiporter subunit E
EN12_14790	ENOG4108JPZ	Monovalent cation H antiporter subunit D
EN12_14795	ENOG4105MKQ	Monovalent cation H antiporter subunit C
EN12_14800	ENOG4105D65	subunit l
EN12_14810	ENOG4105Q9Y	Universal stress protein
EN12_14815	ENOG4105CIC	tryptophan-specific transport protein
EN12_14820	ENOG4105C0F	tryptophanase EC 4.1.99.1
EN12_14825	ENOG4105VRT	cytoplasmic protein
EN12_14840	ENOG4105BZU	Histidine kinase
EN12_14845	ENOG4105VEQ	Cold shock protein
EN12_14880	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
EN12_14885	ENOG41069D7	Methyl-accepting chemotaxis
EN12_14900	ENOG4105D9N	nucleoside
EN12_14905	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
EN12_14915	ENOG4108JUA	Transcriptional regulator
EN12_14920	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
EN12_14925	ENOG4105VEQ	Cold shock protein
EN12_14950	ENOG4108UNF	response regulator
EN12_14960	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
EN12_14965	ENOG4105C5I	Dehydrogenase
EN12_14985	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EN12_15010	ENOG4108RS6	transposase
EN12_15015	ENOG4105C1J	atp-dependent rna helicase
EN12_15020	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
EN12_15025	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
EN12_15030	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
EN12_15035	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EN12_15040	ENOG4105BZU	Histidine kinase
EN12_15050	ENOG4107S6Z	Na H antiporter
EN12_15055	ENOG4105E5M	Multidrug resistance protein D
EN12_15065	ENOG4105BZU	Histidine kinase
EN12_15070	ENOG4105KUU	lipolytic protein G-D-S-L family
EN12_15075	ENOG4106M3D	hemolysin
EN12_15080	ENOG4108N3W	hemolysin secretion protein
EN12_15085	ENOG4107IFA	Lipase (EC 3.1.1.3)
EN12_15095	ENOG4107G87	m6 family metalloprotease domain protein
EN12_15115	ENOG4105DHS	permease protein
EN12_15120	ENOG4105CM4	permease protein
EN12_15125	ENOG4108IPW	abc transporter atp-binding protein
EN12_15145	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
EN12_15165	ENOG4105ETX	regulatoR
EN12_15180	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
EN12_15190	ENOG410667J	hydrolase
EN12_15220	ENOG4105DS1	cytochrome b561
EN12_15245	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
EN12_15250	ENOG4105BZU	Histidine kinase
EN12_15275	ENOG4107QVI	Methyltransferase, type 11
EN12_15290	ENOG4105C2C	drug resistance transporter, Bcr CflA
EN12_15295	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_15305	ENOG4105DZ1	carboxypeptidase
EN12_15325	ENOG4108RS6	transposase
EN12_15330	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EN12_15335	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
EN12_15340	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EN12_15350	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
EN12_15360	ENOG4105F2I	Transposase
EN12_15385	ENOG4105C22	threonyL-tRNA synthetase
EN12_15390	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
EN12_15395	ENOG41082NX	50s ribosomal protein l35
EN12_15400	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
EN12_15435	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
EN12_15475	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
EN12_15505	ENOG4105D9U	N-acetyltransferase
EN12_15510	ENOG4105QNF	Outer membrane lipoprotein
EN12_15535	ENOG4105VXN	addiction module toxin, RelE StbE family
EN12_15545	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
EN12_15590	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
EN12_15620	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
EN12_15635	ENOG4105QNF	Outer membrane lipoprotein
EN12_15665	ENOG4105QNF	Outer membrane lipoprotein
EN12_15680	ENOG4105YGK	Pfam:UPF0157
EN12_15685	ENOG4105N14	lysine exporter protein LysE YggA
EN12_15885	ENOG41080ET	plasmid maintenance system killer protein
EN12_15890	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
EN12_15905	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
EN12_15910	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
EN12_15930	ENOG4105QNF	Outer membrane lipoprotein
EN12_16020	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
EN12_16040	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
EN12_16045	ENOG4105W08	virulence gene repressor rsal
EN12_16060	ENOG4105F2I	Transposase
EN12_16080	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
EN12_16165	ENOG4108RS6	transposase
EN12_16225	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
EN12_16250	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
EN12_16255	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
EN12_16260	ENOG4105CGF	Aromatic amino acid aminotransferase
EN12_16265	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
EN12_16275	ENOG4105DM4	PTS System
EN12_16280	ENOG4105DE4	1-phosphofructokinase
EN12_16285	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
EN12_16290	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
EN12_16295	ENOG4107RFY	SbcCD D subunit
EN12_16300	ENOG4105EYH	Exonuclease
EN12_16305	ENOG4108MGY	Histidine kinase
EN12_16310	ENOG4107KBT	8-Amino-7-oxononanoate synthase
EN12_16320	ENOG4105CMQ	Chloride channel
EN12_16325	ENOG4105CKI	cobalamin synthesis protein
EN12_16330	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
EN12_16335	ENOG4105DFH	Transport of potassium into the cell (By similarity)
EN12_16340	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
EN12_16345	ENOG4105C08	Histidine kinase
EN12_16350	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
EN12_16355	ENOG410607N	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity)
EN12_16360	ENOG4108RHM	integral membrane protein
EN12_16370	ENOG4105EPM	Diguanylate phosphodiesterase
EN12_16380	ENOG4105DS1	cytochrome b561
EN12_16390	ENOG4105TMB	Formate nitrite transporter
EN12_16395	ENOG4105DUM	transcriptional regulator, lysR family
EN12_16400	ENOG4108UQ5	membrane protein YcdZ
EN12_16405	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
EN12_16410	ENOG4105CGH	5'-nucleotidase
EN12_16415	ENOG4105DU1	integral membrane protein, terc
EN12_16425	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
EN12_16460	ENOG4105BZU	Histidine kinase
EN12_16470	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
EN12_16480	ENOG4105BZU	Histidine kinase
EN12_16495	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
EN12_16500	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
EN12_16510	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EN12_16535	ENOG4108ZJT	translation initiation factor, Sui1
EN12_16545	ENOG4105CPF	Cell wall formation (By similarity)
EN12_16555	ENOG4105CD5	CoA-binding domain protein
EN12_16560	ENOG4105CWB	LysR family transcriptional Regulator
EN12_16580	ENOG4105KA0	thioesterase Superfamily protein
EN12_16600	ENOG4105CYM	Glutathione S-transferase
EN12_16615	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
EN12_16620	ENOG4108JQ5	ABC transporter
EN12_16625	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
EN12_16630	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
EN12_16635	ENOG4105E43	Extracellular solute-binding protein, family 5
EN12_16660	ENOG4105DUX	Transporter
EN12_16675	ENOG4107RCV	ABC transporter, permease
EN12_16690	ENOG4107STF	Involved in phosphonate degradation (By similarity)
EN12_16695	ENOG4108JPW	Aminotransferase
EN12_16700	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
EN12_16705	ENOG4105NXH	GreA GreB family elongation factor
EN12_16710	ENOG4105PAD	Hydrolase
EN12_16720	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
EN12_16725	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
EN12_16730	ENOG4105CKU	formyltetrahydrofolate synthetase
EN12_16735	ENOG4105E0X	reductase
EN12_16740	ENOG4105EUJ	GTP cyclohydrolase i
EN12_16745	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
EN12_16750	ENOG4105D06	uba thif-type nad fad binding protein
EN12_16760	ENOG4105KHC	sulfurtransferase
EN12_16765	ENOG4107RHR	regulatoR
EN12_16775	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
EN12_16780	ENOG4105CV1	Transketolase (EC 2.2.1.1)
EN12_16805	ENOG4108M3J	Dehydrogenase
EN12_16820	ENOG4105RA2	Membrane
EN12_16830	ENOG4105ETT	transcriptional Regulator, LysR family
EN12_16835	ENOG41067V3	Antibiotic biosynthesis monooxygenase
EN12_16865	ENOG41080HT	Transcriptional regulator, arsr family
EN12_16875	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
EN12_16920	ENOG4105C5Y	PTS System
EN12_16925	ENOG4105ETE	Transcriptional regulator (LacI family
EN12_16930	ENOG4107R3K	hydrolase
EN12_16935	ENOG4105D7K	pfkb domain protein
EN12_16940	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
EN12_16945	ENOG4108NVR	Methyl-accepting chemotaxis
EN12_16950	ENOG4108ZG0	Ompa motb domain protein
EN12_16955	ENOG4108V1T	peptidylprolyl cis-trans isomerase
EN12_16960	ENOG4107VXZ	Hydrolase
EN12_16965	ENOG4108N3W	hemolysin secretion protein
EN12_16970	ENOG4105CEE	C4-dicarboxylate transporter
EN12_16975	ENOG4105EJQ	L-serine dehydratase
EN12_16995	ENOG4105ETE	Transcriptional regulator (LacI family
EN12_17000	ENOG4105WH1	Two component transcriptional regulator luxr family
EN12_17005	ENOG4105BZU	Histidine kinase
EN12_17020	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
EN12_17040	ENOG4105DHT	Metal Dependent Phosphohydrolase
EN12_17045	ENOG4108KX4	response regulator
EN12_17050	ENOG4105BZU	Histidine kinase
EN12_17055	ENOG4105CXY	transporter
EN12_17060	ENOG4105C4Y	ABC transporter
EN12_17065	ENOG4107RCV	ABC transporter, permease
EN12_17070	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EN12_17075	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
EN12_17085	ENOG4105CHU	acetyl-coa acetyltransferase
EN12_17095	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EN12_17100	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EN12_17115	ENOG4105BZU	Histidine kinase
EN12_17120	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
EN12_17130	ENOG4108I6A	alcohol dehydrogenase
EN12_17140	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
EN12_17150	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
EN12_17155	ENOG4105CXY	transporter
EN12_17160	ENOG4105CA9	Pyruvate kinase
EN12_17165	ENOG4105BZU	Histidine kinase
EN12_17170	ENOG4108SV3	Tmao reductase system periplasmic protein tort
EN12_17175	ENOG4108Z5K	methylglyoxal synthase
EN12_17180	ENOG4108RWI	nicotinamidase
EN12_17185	ENOG41080IJ	Diacylglycerol kinase
EN12_17200	ENOG41088T4	Helicase IV
EN12_17205	ENOG4105EM2	membrane
EN12_17235	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
EN12_17240	ENOG4105E0C	molybdate abc transporter
EN12_17245	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
EN12_17250	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
EN12_17295	ENOG4105BZU	Histidine kinase
EN12_17300	ENOG4108QGH	periplasmic
EN12_17310	ENOG41082IR	Excinuclease ABC C subunit domain protein
EN12_17340	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EN12_17350	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
EN12_17355	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
EN12_17360	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
EN12_17365	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EN12_17370	ENOG4105K63	Thioredoxin
EN12_17400	ENOG4105DUM	transcriptional regulator, lysR family
EN12_17405	ENOG4105DMR	ABC, transporter
EN12_17410	ENOG4105GBT	ABC transporter
EN12_17415	ENOG4106PMH	Extracellular solute-binding protein family 3
EN12_17420	ENOG4105E5Z	arginine transporter ATP-binding subunit
EN12_17430	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
EN12_17440	ENOG4108YZ4	nudix hydrolase
EN12_17445	ENOG4105C5W	Aldolase
EN12_17450	ENOG4106RE7	Cytochrome
EN12_17455	ENOG4108IG5	Transcriptional regulator
EN12_17460	ENOG4105C1J	atp-dependent rna helicase
EN12_17465	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
EN12_17475	ENOG4105E0U	tyrosine-specific transport protein
EN12_17480	ENOG4108N3W	hemolysin secretion protein
EN12_17485	ENOG4105CMR	udp-glucose 4-epimerase
EN12_17490	ENOG4105E7W	lamb ycsf family protein
EN12_17500	ENOG4107R7A	Allophanate hydrolase subunit 2
EN12_17510	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
EN12_17515	ENOG4105CV6	ABC transporter, permease
EN12_17520	ENOG4108I0Y	(ABC) transporter
EN12_17530	ENOG4105RKW	reductase (By
EN12_17550	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EN12_17595	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EN12_17610	ENOG4107RE1	Inosine-guanosine kinase
EN12_17615	ENOG4105E0M	Sulfatase
EN12_17625	ENOG4105C1J	atp-dependent rna helicase
EN12_17630	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
EN12_17640	ENOG4105CVA	phosphate
EN12_17650	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
EN12_17655	ENOG4108M1A	Chitin-binding protein
EN12_17660	ENOG4105D4Y	metalloprotease
EN12_17670	ENOG4105CYW	agmatinase
EN12_17675	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
EN12_17685	ENOG4105CJW	magnesium transporter
EN12_17690	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EN12_17695	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EN12_17705	ENOG4105CZK	Aspartate kinase
EN12_17710	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
EN12_17715	ENOG4108JPW	Aminotransferase
EN12_17720	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
EN12_17725	ENOG41090A4	Pterin carbinolamine dehydratase
EN12_17730	ENOG4105MIR	Phenylalanine 4-monooxygenase
EN12_17735	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EN12_17750	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
EN12_17755	ENOG4105EGI	Transcriptional regulator
EN12_17770	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
EN12_17775	ENOG4105C37	(CBS) domain
EN12_17780	ENOG4108UKZ	OsmC family
EN12_17785	ENOG4107YWA	deoxycytidylate deaminase
EN12_17805	ENOG4105DVH	amino acid
EN12_17810	ENOG4106TD9	Diguanylate cyclase
EN12_17820	ENOG4108VAC	response regulator
EN12_17825	ENOG4108HRK	Histidine kinase
EN12_17840	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EN12_17845	ENOG4105C19	ABC transporter
EN12_17860	ENOG4107RGM	aldo keto reductase
EN12_17865	ENOG4107T9C	Alpha amylase catalytic region
EN12_17880	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
EN12_17885	ENOG4108M0H	Extracellular lipase
EN12_17890	ENOG4107SDU	Methyl-accepting chemotaxis
EN12_17895	ENOG4105D4Y	metalloprotease
EN12_17900	ENOG4105EIF	outer membrane protein W
EN12_17910	ENOG41061WM	D-Alanyl-D-Alanine
EN12_17915	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EN12_17920	ENOG4105C4M	(Ubiquinol oxidase) subunit I
EN12_17925	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
EN12_17935	ENOG4105BZC	d-serine deaminase
EN12_17940	ENOG4105W8I	Transcriptional regulator
EN12_17980	ENOG4105CPQ	Dehydrogenase
EN12_17985	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
EN12_17990	ENOG4105TMR	Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity)
EN12_17995	ENOG4105TMR	Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity)
EN12_18005	ENOG4105EXG	Transcriptional regulator
EN12_18010	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
EN12_18030	ENOG4107SSZ	Phosphatase
EN12_18035	ENOG4105DHT	Metal Dependent Phosphohydrolase
EN12_18040	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
EN12_18045	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
EN12_18050	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
EN12_18075	ENOG4105BZW	Glycerate kinase
EN12_18080	ENOG4105C6Z	Gluconate
EN12_18085	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
EN12_18090	ENOG4108NVR	Methyl-accepting chemotaxis
EN12_18095	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
EN12_18100	ENOG41090JE	Utilization Protein
EN12_18105	ENOG4105D4P	Coproporphyrinogen iii oxidase
EN12_18110	ENOG4105WQ5	TonB family
EN12_18115	ENOG41090AP	transport protein
EN12_18120	ENOG4106GFD	transport protein
EN12_18125	ENOG4107R4I	Periplasmic binding protein
EN12_18130	ENOG4105EHG	Permease protein
EN12_18135	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
EN12_18165	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_18170	ENOG4105QVC	MOSC domain-containing protein
EN12_18170	ENOG4105QVC	MOSC domain-containing protein
EN12_18175	ENOG4105EKE	dihydroorotase
EN12_18185	ENOG4105KAF	membrAne
EN12_18195	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
EN12_18200	ENOG4105CKW	Inner membrane protein yedI
EN12_18205	ENOG4108ESY	Metal dependent phosphohydrolase
EN12_18210	ENOG4105VEQ	Cold shock protein
EN12_18235	ENOG4105BZU	Histidine kinase
EN12_18240	ENOG4105E98	transcriptional regulator DeoR family
EN12_18255	ENOG4105EG2	ABC transporter, permease
EN12_18260	ENOG4105D56	permease protein
EN12_18265	ENOG4107FKK	extracellular solute-binding protein family 1
EN12_18270	ENOG4108IJ9	(ABC) transporter
EN12_18275	ENOG4108HK0	-acetyltransferase
EN12_18290	ENOG4105K8R	UPF0145 protein
EN12_18295	ENOG41086KC	Transcriptional regulator
EN12_18300	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
EN12_18305	ENOG4107R88	Chemotaxis protein (CheV)
EN12_18310	ENOG4105K56	Transcriptional regulator
EN12_18315	ENOG4106TD9	Diguanylate cyclase
EN12_18330	ENOG4105BZU	Histidine kinase
EN12_18350	ENOG4105ETT	transcriptional Regulator, LysR family
EN12_18355	ENOG4108K0B	C-di-gmp phosphodiesterase
EN12_18365	ENOG4105EUB	pirin domain protein
EN12_18370	ENOG4105NBK	UPF0345 protein
EN12_18380	ENOG4105E5W	Transporter
EN12_18390	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_18395	ENOG4105DAN	ATP-dependent protease
EN12_18405	ENOG4108JQ5	ABC transporter
EN12_18410	ENOG4108RS6	transposase
EN12_18415	ENOG4105E89	ABC transporter
EN12_18420	ENOG4107SDU	Methyl-accepting chemotaxis
EN12_18435	ENOG4105CC0	LysR family Transcriptional regulator
EN12_18440	ENOG4105DAA	L-lactate
EN12_18445	ENOG4105DMF	Dehydrogenase
EN12_18455	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
EN12_18470	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
EN12_18480	ENOG4105C1J	atp-dependent rna helicase
EN12_18485	ENOG4105CR8	Transcriptional regulator
EN12_18495	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
EN12_18505	ENOG4105BZ1	(ABC) transporter
EN12_18515	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
EN12_18550	ENOG4105K56	Transcriptional regulator
EN12_18555	ENOG4108ZHJ	Organic hydroperoxide resistance protein
EN12_18570	ENOG4108SXK	Transporter Drug Metabolite Exporter family
EN12_18575	ENOG4105VW4	glutaredoxin 3
EN12_18580	ENOG4108P2H	Inner membrane protein YjiG
EN12_18585	ENOG41074DU	domain protein
EN12_18590	ENOG4105DN9	Na H antiporter
EN12_18600	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
EN12_18605	ENOG4105D03	DNA-3-methyladenine glycosylase II
EN12_18610	ENOG4108VGI	doxx family
EN12_18635	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
EN12_18645	ENOG4107W52	maltose operon periplasmic protein
EN12_18650	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
EN12_18665	ENOG4108N3W	hemolysin secretion protein
EN12_18680	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_18690	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
EN12_18695	ENOG4105CDA	abc transporter atp-binding protein
EN12_18705	ENOG4106TNF	Periplasmic binding protein
EN12_18710	ENOG4105EZ7	amino acid ABC transporter
EN12_18715	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
EN12_18725	ENOG4105DR5	peptidase
EN12_18735	ENOG4105CTS	PTS system mannitol-specific
EN12_18740	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
EN12_18745	ENOG4105E61	Mannitol repressor protein
EN12_18750	ENOG4105EP9	oxidoreductase
EN12_18780	ENOG4108RYK	Nad-dependent epimerase dehydratase
EN12_18785	ENOG4105JQN	Transcriptional regulator
EN12_18790	ENOG41069D7	Methyl-accepting chemotaxis
EN12_18795	ENOG4105EMU	Dehydrogenase
EN12_18800	ENOG4105JQN	Transcriptional regulator
EN12_18810	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
EN12_18820	ENOG4105D5Q	Arginine ornithine antiporter
EN12_18825	ENOG4105CXN	decarboxylase
EN12_18830	ENOG4107RGH	Aldehyde dehydrogenase
EN12_18835	ENOG4105EW9	transcriptional regulator AsnC family
EN12_18840	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_18850	ENOG4105CK7	Sodium proline symporter
EN12_18860	ENOG4105C26	Dehydrogenase
EN12_18875	ENOG4105E6M	Sulphatase-modifying factor protein
EN12_18885	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
EN12_18890	ENOG4107QZV	Type I secretion membrane fusion protein
EN12_18905	ENOG4108JJA	ABC, transporter
EN12_18915	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EN12_18925	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_18930	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
EN12_18935	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
EN12_18940	ENOG4105BZU	Histidine kinase
EN12_18945	ENOG4105C8Q	Methyl-accepting chemotaxis
EN12_18950	ENOG4108V3W	Chemotaxis protein, CheW
EN12_18955	ENOG4108V3W	Chemotaxis protein, CheW
EN12_18960	ENOG4105CBS	Chea signal transduction histidine kinase
EN12_18965	ENOG4108VYJ	response regulator receiver protein
EN12_18985	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
EN12_18990	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EN12_18995	ENOG4108JQ6	ABC transporter
EN12_19000	ENOG4105DIJ	Phosphoethanolamine transferase
EN12_19005	ENOG4105DHQ	Histidine kinase
EN12_19010	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
EN12_19040	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
EN12_19045	ENOG4107RUE	extracellular solute-binding protein family 1
EN12_19050	ENOG4106RMF	ParB family
EN12_19060	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
EN12_19125	ENOG4107QHF	type ii secretion system protein e
EN12_19155	ENOG4107QHF	type ii secretion system protein e
EN12_19170	ENOG4107QHF	type ii secretion system protein e
EN12_19230	ENOG4105CJB	Exodeoxyribonuclease I
EN12_19290	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
EN12_19295	ENOG4105C2M	dna polymerase I
EN12_19335	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
EN12_19345	ENOG4105C4R	Atp-dependent dna helicase
EN12_19355	ENOG4108IYH	Dna topoisomerase
EN12_19360	ENOG4105BZU	Histidine kinase
EN12_19380	ENOG4105CB5	ATP-dependent DNA helicase recG
EN12_19385	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
EN12_19400	ENOG4105C0B	DNA polymerase III (alpha subunit)
EN12_19405	ENOG4105CDU	Replicative dna helicase
EN12_19410	ENOG4107RZZ	dna polymerase iii epsilon subunit
EN12_19420	ENOG4105DZP	Membrane-associated zinc metalloprotease
EN12_19440	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
EN12_19450	ENOG4105C7H	Helicase, RecD TraA family
EN12_19460	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EN12_19495	ENOG4107QHF	type ii secretion system protein e
EN12_19555	ENOG4105DH7	May be involved in recombination (By similarity)
EN12_19590	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
EN12_19620	ENOG4105DCI	Phosphohydrolase
EN12_19630	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EN12_19640	ENOG4105F8J	Adenylate Guanylate cyclase
EN12_19695	ENOG4108JA2	transcriptioN-repair coupling factor
EN12_19780	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
EN12_19810	ENOG4107QUV	Domain protein
EN12_19880	ENOG4105C3J	Cysteine desulfurase
EN12_19895	ENOG4105C4R	Atp-dependent dna helicase
EN12_19910	ENOG4105D7V	transposase
EN12_20010	ENOG4105D70	Integrase catalytic subunit
EN12_20015	ENOG4105F5W	AtP-binding protein
EN12_20065	ENOG4105D7V	transposase
EN12_20200	ENOG4105BZU	Histidine kinase
EN12_20215	ENOG4105D58	Diguanylate phosphodiesterase
EN12_20240	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
EN12_20255	ENOG4106FN3	tellurium resistance protein
EN12_20270	ENOG4105DAX	Pfam:DUF2983
EN12_20305	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EN12_20310	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EN12_20340	ENOG4105DS1	cytochrome b561
EN12_20345	ENOG4108YYC	ycei family
EN12_20380	ENOG4105DFE	Dna adenine methylase
EN12_20415	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EN12_20420	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
EN12_20425	ENOG4107RH7	Nicotinate phosphoribosyltransferase
EN12_20445	ENOG4108M8H	domain protein
EN12_20470	ENOG4107104	thymidine kinase
EN12_20485	ENOG4108Z4V	iron-sulfur cluster assembly
EN12_20490	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
EN12_20500	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EN12_20515	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
EN12_20565	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
EN12_20595	ENOG4105UYK	outer membrane protein a
EN12_20610	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
EN12_20870	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
EN12_20885	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EN12_20890	ENOG4105MUA	Resistance protein
EN12_20965	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
EN12_20970	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
EN12_21000	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
EN12_21065	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
EN12_21105	ENOG4105C2M	dna polymerase I
EN12_21235	ENOG4105EKQ	RNA-directed DNA polymerase
EN12_21240	ENOG4105D7V	transposase
EN12_21265	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
EN12_21310	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
EN12_21315	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EN12_21325	ENOG4105DIJ	Phosphoethanolamine transferase
EN12_21330	ENOG41080IJ	Diacylglycerol kinase
EN12_21405	ENOG4105DAX	Pfam:DUF2983
EN12_21415	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EN12_21440	ENOG4108MN8	Membrane
EN12_21450	ENOG41087A8	Modulates RecA activity (By similarity)
EN12_21540	ENOG4108B1Q	Ribonuclease
EN12_21565	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
EN12_21630	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
EN12_21635	ENOG4108R1E	Serine threonine protein phosphatase 1
EN12_21735	ENOG4108UUM	single-stranded DNA-binding protein
EN12_21830	ENOG4105DSF	transport protein
EN12_21850	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
EN12_21895	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
EN12_22115	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
EN12_22135	ENOG4105D70	Integrase catalytic subunit
EN12_22140	ENOG4105F5W	AtP-binding protein
EN12_22150	ENOG4105C2U	cobyrinic Acid a,c-diamide synthase
EN12_22155	ENOG41090BQ	Glutaredoxin
EN12_22160	ENOG4105K70	DNA-binding protein
EN12_22195	ENOG4105D7V	transposase
EN12_22240	ENOG41065RQ	ADP-ribosylation crystallin J1
EN12_22310	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
EN12_22330	ENOG4106JGA	Chromosome (Plasmid) partitioning protein, ParB
EN12_22480	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EN12_22555	ENOG4106CKV	Pap2 superfamily protein
EN12_22720	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
EN12_22995	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
EN12_23165	ENOG4108Z12	YiaAB two helix domain-containing protein
EN12_23325	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
EN12_23380	ENOG4107IIZ	CRISPR-associated helicase, Cas3
EN12_23420	ENOG4105D7V	transposase
EN12_23500	ENOG4108UUM	single-stranded DNA-binding protein
EN12_23700	ENOG4108YZ4	nudix hydrolase
EN12_23745	ENOG4105D7V	transposase
EN12_23750	ENOG4105EKQ	RNA-directed DNA polymerase
EN12_23755	ENOG4105D7V	transposase
EN12_23825	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
EN12_23845	ENOG4105DVT	helicase
EN12_23885	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
EN12_23905	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EN12_23950	ENOG4108NVR	Methyl-accepting chemotaxis
EN12_23955	ENOG410902V	Modulates RecA activity (By similarity)
EN12_24030	ENOG4105D7V	transposase
EN12_24085	ENOG4107QHF	type ii secretion system protein e
EN12_24165	ENOG4108UVJ	appr-1-p processing domain protein
EN12_24415	ENOG4105EHV	domain protein