locus-tag	class	description
EN12_00015	COG1126	abc transporter atp-binding protein
EN12_00020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EN12_00025	COG0594	ribonuclease P activity
EN12_00030	COG0706	membrane insertase activity
EN12_00035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EN12_00040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN12_00045	COG0445	tRNA wobble uridine modification
EN12_00050	COG0357	Ribosomal RNA small subunit methyltransferase G
EN12_00055	COG1192	Involved in chromosome partitioning
EN12_00060	COG1475	DNA binding
EN12_00065	COG3312	ion transport
EN12_00070	COG0356	it plays a direct role in the translocation of protons across the membrane
EN12_00080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EN12_00085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EN12_00090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EN12_00095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EN12_00100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EN12_00105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EN12_00110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EN12_00115	COG2814	Major facilitator Superfamily
EN12_00120	COG0583	DNA-binding transcription factor activity
EN12_00125	COG0183	Belongs to the thiolase family
EN12_00130	COG1024	Enoyl-CoA hydratase
EN12_00130	COG1250	3-hydroxyacyl-CoA dehydrogenase
EN12_00135	COG1739	Uncharacterized protein family UPF0029
EN12_00140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN12_00145	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EN12_00190	COG0583	DNA-binding transcription factor activity
EN12_00195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EN12_00200	COG2960	long-chain fatty acid transporting porin activity
EN12_00205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN12_00210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_00215	COG1309	transcriptional regulator
EN12_00265	COG0747	negative chemotaxis
EN12_00275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN12_00285	COG2131	deaminase
EN12_00350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_00355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EN12_00365	COG0210	DNA helicase
EN12_00370	COG1280	lysine exporter protein (LysE YggA)
EN12_00390	COG0514	ATP-dependent DNA helicase (RecQ)
EN12_00405	COG1132	(ABC) transporter
EN12_00410	COG4774	siderophore transport
EN12_00415	COG1120	ATPase activity
EN12_00435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN12_00440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_00440	COG1263	PTS System
EN12_00450	COG1561	YicC-like family, N-terminal region
EN12_00455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EN12_00460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EN12_00465	COG1560	Kdo2-lipid A biosynthetic process
EN12_00470	COG1560	Kdo2-lipid A biosynthetic process
EN12_00475	COG1309	transcriptional regulator
EN12_00480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EN12_00495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EN12_00500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EN12_00510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EN12_00515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EN12_00520	COG0859	PFAM glycosyl transferase family 9
EN12_00525	COG0463	Glycosyl transferase, family 2
EN12_00530	COG0859	PFAM glycosyl transferase family 9
EN12_00535	COG3642	lipopolysaccharide core region biosynthetic process
EN12_00565	COG1519	Transferase
EN12_00600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN12_00605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EN12_00605	COG0662	Cupin 2, conserved barrel domain protein
EN12_00610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN12_00615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EN12_00645	COG0318	PFAM AMP-dependent synthetase and ligase
EN12_00650	COG1454	alcohol dehydrogenase
EN12_00650	COG1012	belongs to the aldehyde dehydrogenase family
EN12_00665	COG5433	transposase activity
EN12_00695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN12_00700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EN12_00705	COG0668	transmembrane transport
EN12_00710	COG1573	uracil-dna glycosylase
EN12_00720	COG3068	Protein conserved in bacteria
EN12_00730	COG1940	carbohydrate kinase activity
EN12_00735	COG1253	flavin adenine dinucleotide binding
EN12_00740	COG0776	regulation of translation
EN12_00750	COG0151	Belongs to the GarS family
EN12_00755	COG0138	bifunctional purine biosynthesis protein purh
EN12_00760	COG0789	Transcriptional regulator
EN12_00765	COG3710	Transcriptional regulator
EN12_00770	COG0531	amino acid
EN12_00775	COG1982	Orn Lys Arg decarboxylase major
EN12_00780	COG0840	transmembrane signaling receptor activity
EN12_00800	COG0800	Aldolase
EN12_00810	COG3265	gluconokinase activity
EN12_00815	COG0129	dihydroxy-acid dehydratase activity
EN12_00820	COG1609	Transcriptional regulator
EN12_00825	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EN12_00830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN12_00835	COG2264	protein methyltransferase activity
EN12_00840	COG0439	Biotin carboxylase
EN12_00845	COG0511	ligase activity, forming carbon-carbon bonds
EN12_00850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EN12_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EN12_00870	COG2814	Major facilitator Superfamily
EN12_00875	COG0784	Response regulator, receiver
EN12_00875	COG2205	protein histidine kinase activity
EN12_00880	COG0248	Ppx GppA phosphatase
EN12_00885	COG0513	Belongs to the DEAD box helicase family
EN12_00890	COG3118	belongs to the thioredoxin family
EN12_00895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EN12_00905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EN12_00950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EN12_00960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EN12_00970	COG1072	(Pantothenic acid kinase))
EN12_00995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN12_01000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN12_01005	COG0250	Participates in transcription elongation, termination and antitermination
EN12_01010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EN12_01015	COG0081	regulation of translation
EN12_01020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EN12_01025	COG0222	ribosome binding
EN12_01030	COG0085	RNA polymerase activity
EN12_01035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EN12_01040	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EN12_01045	COG2816	NAD+ diphosphatase activity
EN12_01050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EN12_01065	COG4942	peptidase
EN12_01070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EN12_01080	COG0471	metal ion transport
EN12_01085	COG0688	phosphatidylethanolamine metabolic process
EN12_01090	COG1162	GTPase activity
EN12_01095	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EN12_01145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EN12_01150	COG0802	atpase or kinase
EN12_01160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EN12_01165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EN12_01170	COG1923	regulation of RNA biosynthetic process
EN12_01175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EN12_01180	COG0330	HflC and HflK could
EN12_01185	COG0330	HflC and HflK could
EN12_01190	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EN12_01195	COG2900	Belongs to the SlyX family
EN12_01205	COG0545	Peptidyl-prolyl cis-trans isomerase
EN12_01210	COG2964	Protein conserved in bacteria
EN12_01215	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EN12_01220	COG2923	Belongs to the DsrF TusC family
EN12_01230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EN12_01235	COG0049	tRNA binding
EN12_01240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN12_01245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN12_01250	COG2906	2 iron, 2 sulfur cluster binding
EN12_01260	COG0360	Binds together with S18 to 16S ribosomal RNA
EN12_01265	COG2965	DNA replication, synthesis of RNA primer
EN12_01270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EN12_01275	COG0359	binds to the 23S rRNA
EN12_01285	COG0305	Participates in initiation and elongation during chromosome replication
EN12_01290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN12_01295	COG0432	Pfam Uncharacterised protein family UPF0047
EN12_01300	COG0166	Belongs to the GPI family
EN12_01315	COG0735	belongs to the Fur family
EN12_01320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN12_01340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN12_01345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EN12_01350	COG0175	sulfate reduction
EN12_01390	COG1410	methionine synthase
EN12_01390	COG0646	methionine synthase
EN12_01395	COG0527	aspartate kinase activity
EN12_01400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EN12_01410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EN12_01425	COG0629	single-stranded DNA binding
EN12_01430	COG2200	EAL domain
EN12_01430	COG2199	diguanylate cyclase activity
EN12_01455	COG3267	Type II secretory pathway component ExeA
EN12_01455	COG3409	Peptidoglycan-binding domain 1 protein
EN12_01465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_01470	COG1459	type II secretion system
EN12_01515	COG1077	Cell shape determining protein MreB Mrl
EN12_01520	COG1792	Involved in formation and maintenance of cell shape
EN12_01525	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EN12_01530	COG0424	maF-like protein
EN12_01535	COG1530	ribonuclease E activity
EN12_01540	COG3164	Protein of unknown function
EN12_01545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EN12_01550	COG0312	modulator of DNA gyrase
EN12_01555	COG2235	arginine
EN12_01575	COG0589	response to stress
EN12_01590	COG1438	arginine binding
EN12_01595	COG0039	L-malate dehydrogenase activity
EN12_01600	COG0531	amino acid
EN12_01605	COG0531	amino acid
EN12_01610	COG0142	geranyltranstransferase activity
EN12_01615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EN12_01620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EN12_01625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EN12_01630	COG2966	Psort location CytoplasmicMembrane, score
EN12_01635	COG3610	response to peptide
EN12_01645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EN12_01650	COG2967	ApaG domain
EN12_01655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EN12_01660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EN12_01665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN12_01670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EN12_01675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN12_01730	COG0741	lytic transglycosylase activity
EN12_01735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EN12_01740	COG1194	a g-specific adenine glycosylase
EN12_01745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EN12_01750	COG2066	Belongs to the glutaminase family
EN12_01755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EN12_01760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EN12_01770	COG1872	DUF167
EN12_01775	COG0762	integral membrane protein
EN12_01780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EN12_01785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EN12_01805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN12_01810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EN12_01815	COG1678	Uncharacterized ACR, COG1678
EN12_01820	COG0189	ligase activity
EN12_01825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EN12_01830	COG2356	endonuclease I
EN12_01835	COG3091	SprT-like family
EN12_01840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EN12_01850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EN12_01855	COG0583	DNA-binding transcription factor activity
EN12_01860	COG4771	TonB-dependent receptor
EN12_01865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN12_01870	COG0126	phosphoglycerate kinase activity
EN12_01880	COG0191	fructose-bisphosphate aldolase activity
EN12_01890	COG0668	transmembrane transport
EN12_01895	COG1279	arginine transmembrane transporter activity
EN12_01900	COG0583	DNA-binding transcription factor activity
EN12_01910	COG0469	pyruvate kinase activity
EN12_01915	COG1349	DNA-binding transcription factor activity
EN12_01920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EN12_01925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN12_01990	COG0739	heme binding
EN12_02025	COG2003	Belongs to the UPF0758 family
EN12_02035	COG0840	transmembrane signaling receptor activity
EN12_02040	COG2207	Transcriptional regulator
EN12_02050	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN12_02055	COG0582	viral genome integration into host DNA
EN12_02065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN12_02070	COG0358	DNA primase activity
EN12_02075	COG1610	YqeY-like protein
EN12_02080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EN12_02085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EN12_02095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EN12_02100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EN12_02105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN12_02110	COG1968	undecaprenyl-diphosphatase activity
EN12_02115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EN12_02120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EN12_02125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EN12_02130	COG0585	pseudouridine synthase activity
EN12_02135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EN12_02140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EN12_02145	COG4942	peptidase
EN12_02145	COG1388	LysM domain
EN12_02150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN12_02155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EN12_02175	COG4208	sulfate ABC transporter
EN12_02180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EN12_02190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EN12_02195	COG2137	regulation of response to DNA damage stimulus
EN12_02200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EN12_02210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EN12_02260	COG3630	sodium ion export across plasma membrane
EN12_02265	COG0511	ligase activity, forming carbon-carbon bonds
EN12_02265	COG5016	pyruvate
EN12_02270	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN12_02280	COG1238	metal cluster binding
EN12_02285	COG0612	Peptidase, M16
EN12_02290	COG2918	glutathione biosynthetic process
EN12_02295	COG1854	S-ribosylhomocysteine lyase activity
EN12_02300	COG4536	flavin adenine dinucleotide binding
EN12_02305	COG4137	Cytochrome C assembly protein
EN12_02310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EN12_02315	COG0228	four-way junction DNA binding
EN12_02320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EN12_02325	COG0336	Belongs to the RNA methyltransferase TrmD family
EN12_02330	COG0335	large ribosomal subunit rRNA binding
EN12_02335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN12_02340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN12_02350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EN12_02355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EN12_02360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EN12_02365	COG0723	plastoquinol--plastocyanin reductase activity
EN12_02370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EN12_02375	COG2857	Cytochrome c1
EN12_02380	COG0625	glutathione transferase activity
EN12_02385	COG2969	positive regulation of protein catabolic process
EN12_02390	COG2823	Periplasmic or secreted lipoprotein
EN12_02395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN12_02400	COG0792	nuclease activity
EN12_02405	COG3107	peptidoglycan biosynthetic process
EN12_02410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EN12_02425	COG0288	reversible hydration of carbon dioxide
EN12_02430	COG0659	secondary active sulfate transmembrane transporter activity
EN12_02440	COG1131	(ABC) transporter
EN12_02445	COG0842	Transport permease protein
EN12_02450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EN12_02455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EN12_02460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN12_02470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN12_02475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EN12_02480	COG1489	DNA binding
EN12_02490	COG1643	Atp-dependent helicase
EN12_02495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EN12_02500	COG1752	Esterase of the alpha-beta hydrolase superfamily
EN12_02505	COG1049	propionate catabolic process, 2-methylcitrate cycle
EN12_02510	COG3112	Uncharacterised protein family (UPF0231)
EN12_02515	COG0347	Belongs to the P(II) protein family
EN12_02520	COG0004	ammonium transporteR
EN12_02525	COG1840	ABC-type Fe3 transport system, periplasmic component
EN12_02535	COG3842	ATPase activity
EN12_02555	COG2971	BadF BadG BcrA BcrD
EN12_02565	COG4608	Belongs to the ABC transporter superfamily
EN12_02570	COG0444	Belongs to the ABC transporter superfamily
EN12_02575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN12_02580	COG0601	transmembrane transport
EN12_02585	COG0747	negative chemotaxis
EN12_02595	COG2813	Specifically methylates the guanine in position
EN12_02600	COG0628	permease
EN12_02605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EN12_02615	COG0316	Belongs to the HesB IscA family
EN12_02630	COG0739	heme binding
EN12_02635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN12_02640	COG2027	D-alanyl-D-alanine carboxypeptidase
EN12_02645	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN12_02650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN12_02655	COG1534	Rna-binding protein
EN12_02660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EN12_02665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EN12_02670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EN12_02675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN12_02680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN12_02695	COG0779	Required for maturation of 30S ribosomal subunits
EN12_02700	COG0195	Participates in both transcription termination and antitermination
EN12_02705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EN12_02710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EN12_02715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EN12_02720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EN12_02725	COG1185	polyribonucleotide nucleotidyltransferase activity
EN12_02730	COG4785	May be involved in cell division
EN12_02765	COG3153	acetyltransferase
EN12_02830	COG4644	lycopene metabolic process
EN12_02840	COG3173	Aminoglycoside phosphotransferase
EN12_02920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EN12_02945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EN12_02960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EN12_02965	COG1401	restriction endodeoxyribonuclease activity
EN12_03010	COG4584	PFAM Integrase catalytic
EN12_03030	COG1484	DNA-dependent DNA replication
EN12_03080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN12_03095	COG0681	Belongs to the peptidase S26 family
EN12_03135	COG0629	single-stranded DNA binding
EN12_03155	COG0714	Associated with various cellular activities
EN12_03180	COG2003	Belongs to the UPF0758 family
EN12_03290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EN12_03295	COG0513	Belongs to the DEAD box helicase family
EN12_03300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EN12_03310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EN12_03315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EN12_03320	COG2204	response regulator
EN12_03330	COG0667	Aldo Keto reductase
EN12_03335	COG3066	DNA modification
EN12_03345	COG0494	nUDIX hydrolase
EN12_03350	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EN12_03355	COG0730	response to heat
EN12_03360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EN12_03365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EN12_03370	COG1283	sodium-dependent phosphate transmembrane transporter activity
EN12_03375	COG0583	DNA-binding transcription factor activity
EN12_03380	COG0640	Transcriptional regulator
EN12_03385	COG0268	Binds directly to 16S ribosomal RNA
EN12_03390	COG0728	peptidoglycan biosynthetic process
EN12_03395	COG0196	riboflavin kinase activity
EN12_03400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EN12_03405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EN12_03410	COG1047	Peptidyl-prolyl cis-trans
EN12_03415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EN12_03420	COG1966	Carbon starvation protein
EN12_03435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN12_03440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EN12_03445	COG1472	Belongs to the glycosyl hydrolase 3 family
EN12_03450	COG3279	Response regulator of the LytR AlgR family
EN12_03455	COG3275	phosphorelay sensor kinase activity
EN12_03460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN12_03465	COG0287	Prephenate dehydrogenase
EN12_03465	COG1605	Chorismate mutase
EN12_03475	COG0488	(ABC) transporter
EN12_03485	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EN12_03490	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EN12_03495	COG5001	Diguanylate cyclase
EN12_03500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN12_03505	COG0077	Prephenate dehydratase
EN12_03505	COG1605	Chorismate mutase
EN12_03510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN12_03515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_03520	COG0564	pseudouridine synthase activity
EN12_03530	COG0542	response to heat
EN12_03570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EN12_03580	COG2974	May be involved in recombination
EN12_03585	COG0745	RESPONSE REGULATOR receiver
EN12_03590	COG5002	protein histidine kinase activity
EN12_03600	COG0248	Ppx GppA phosphatase
EN12_03605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EN12_03615	COG0581	inorganic phosphate transmembrane transporter activity
EN12_03620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EN12_03635	COG3142	Participates in the control of copper homeostasis
EN12_03640	COG0450	alkyl hydroperoxide reductase
EN12_03645	COG0583	DNA-binding transcription factor activity
EN12_03650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EN12_03660	COG0517	IMP dehydrogenase activity
EN12_03665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EN12_03670	COG0343	queuine tRNA-ribosyltransferase activity
EN12_03675	COG1862	Preprotein translocase
EN12_03680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN12_03685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN12_03690	COG0483	inositol monophosphate 1-phosphatase activity
EN12_03700	COG1959	2 iron, 2 sulfur cluster binding
EN12_03705	COG1104	cysteine desulfurase activity
EN12_03710	COG0822	iron-sulfur transferase activity
EN12_03720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN12_03725	COG0443	Heat shock 70 kDa protein
EN12_03730	COG0633	Ferredoxin
EN12_03735	COG2975	iron-sulfur cluster assembly
EN12_03740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN12_03745	COG0105	UTP biosynthetic process
EN12_03750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EN12_03760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EN12_03765	COG0124	histidyl-tRNA synthetase
EN12_03770	COG2976	Protein conserved in bacteria
EN12_03775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_03780	COG1160	GTP binding
EN12_03795	COG1570	exodeoxyribonuclease VII activity
EN12_03800	COG0517	IMP dehydrogenase activity
EN12_03800	COG0516	GMP reductase activity
EN12_03805	COG0519	Catalyzes the synthesis of GMP from XMP
EN12_03805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EN12_03815	COG1584	GPR1 FUN34 yaaH family protein
EN12_03820	COG3433	isochorismatase activity
EN12_03820	COG1535	isochorismatase
EN12_03825	COG1021	2,3-dihydroxybenzoate-AMP ligase
EN12_03830	COG1169	isochorismate synthase
EN12_03835	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_03845	COG4592	Periplasmic binding protein
EN12_03850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN12_03855	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN12_03860	COG1120	ATPase activity
EN12_03870	COG0583	DNA-binding transcription factor activity
EN12_03875	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EN12_03880	COG1115	amino acid carrier protein
EN12_03885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EN12_03890	COG0583	DNA-binding transcription factor activity
EN12_03905	COG4565	transcriptional regulatory protein
EN12_03915	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN12_03920	COG0511	ligase activity, forming carbon-carbon bonds
EN12_03920	COG5016	pyruvate
EN12_03925	COG3630	sodium ion export across plasma membrane
EN12_03935	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EN12_03940	COG3052	prosthetic group binding
EN12_03945	COG2301	Belongs to the HpcH HpaI aldolase family
EN12_03950	COG3051	citrate lyase alpha subunit
EN12_03955	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
EN12_03960	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EN12_03970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN12_03975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EN12_03980	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EN12_04040	COG1012	belongs to the aldehyde dehydrogenase family
EN12_04060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EN12_04065	COG0840	transmembrane signaling receptor activity
EN12_04070	COG3710	Transcriptional regulator
EN12_04080	COG2165	general secretion pathway protein
EN12_04095	COG4796	Type ii and iii secretion system protein
EN12_04115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_04120	COG1459	type II secretion system
EN12_04130	COG2207	Transcriptional regulator
EN12_04135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EN12_04155	COG0739	heme binding
EN12_04165	COG3064	Membrane
EN12_04175	COG0582	viral genome integration into host DNA
EN12_04180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EN12_04185	COG2867	negative regulation of translational initiation
EN12_04190	COG2914	Belongs to the UPF0125 (RnfH) family
EN12_04195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_04200	COG0497	DNA recombination
EN12_04205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EN12_04210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EN12_04215	COG0443	Heat shock 70 kDa protein
EN12_04220	COG0484	heat shock protein binding
EN12_04250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN12_04255	COG0590	tRNA wobble adenosine to inosine editing
EN12_04265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EN12_04275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EN12_04275	COG0047	phosphoribosylformylglycinamidine synthase activity
EN12_04280	COG1943	Transposase
EN12_04300	COG0442	prolyl-tRNA aminoacylation
EN12_04305	COG1720	tRNA m6t6A37 methyltransferase activity
EN12_04310	COG0254	rRNA binding
EN12_04315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EN12_04320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN12_04325	COG1671	Belongs to the UPF0178 family
EN12_04335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN12_04350	COG3098	single-species biofilm formation
EN12_04355	COG0564	pseudouridine synthase activity
EN12_04360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EN12_04365	COG0142	geranyltranstransferase activity
EN12_04370	COG1722	exodeoxyribonuclease VII activity
EN12_04375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EN12_04385	COG0301	tRNA thio-modification
EN12_04385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN12_04390	COG0583	DNA-binding transcription factor activity
EN12_04395	COG2363	Small membrane protein
EN12_04400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_04405	COG1611	Belongs to the LOG family
EN12_04410	COG3706	GGDEF domain
EN12_04420	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN12_04420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN12_04430	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EN12_04435	COG1464	Belongs to the NlpA lipoprotein family
EN12_04440	COG2011	ABC-type metal ion transport system permease component
EN12_04445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EN12_04450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN12_04455	COG1609	Transcriptional regulator
EN12_04460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_04460	COG1263	PTS System
EN12_04465	COG0366	Alpha amylase catalytic
EN12_04495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN12_04500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN12_04505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EN12_04510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EN12_04515	COG0110	maltose O-acetyltransferase activity
EN12_04535	COG1045	serine acetyltransferase
EN12_04545	COG0438	transferase activity, transferring glycosyl groups
EN12_04555	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EN12_04585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN12_04595	COG1596	polysaccharide export
EN12_04620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EN12_04630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EN12_04635	COG0321	lipoyl(octanoyl) transferase activity
EN12_04640	COG2921	Belongs to the UPF0250 family
EN12_04645	COG1686	Belongs to the peptidase S11 family
EN12_04650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN12_04655	COG0772	Belongs to the SEDS family
EN12_04660	COG0768	penicillin binding
EN12_04665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EN12_04670	COG0799	negative regulation of ribosome biogenesis
EN12_04675	COG1466	dna polymerase III delta subunit
EN12_04680	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EN12_04685	COG0495	leucyl-tRNA aminoacylation
EN12_04690	COG2888	peptidyl-tyrosine sulfation
EN12_04695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EN12_04700	COG4535	Mg2 and Co2 transporter CorC
EN12_04705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EN12_04710	COG1702	phosphate starvation-inducible protein PhoH
EN12_04715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN12_04720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_04725	COG2190	(PTS) system
EN12_04735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_04740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EN12_04745	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EN12_04750	COG3115	cell septum assembly
EN12_04755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EN12_04770	COG0789	Transcriptional regulator
EN12_04775	COG1585	Membrane protein implicated in regulation of membrane protease activity
EN12_04780	COG0330	HflC and HflK could
EN12_04785	COG3118	belongs to the thioredoxin family
EN12_04795	COG0300	oxidoreductase activity
EN12_04800	COG1090	epimerase
EN12_04805	COG0622	Phosphoesterase
EN12_04820	COG3710	Transcriptional regulator
EN12_04825	COG0326	Molecular chaperone. Has ATPase activity
EN12_04830	COG0563	adenylate kinase activity
EN12_04835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EN12_04850	COG0367	asparagine synthase
EN12_04855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EN12_04855	COG4651	solute:proton antiporter activity
EN12_04860	COG1940	carbohydrate kinase activity
EN12_04860	COG1846	Transcriptional regulator
EN12_04865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN12_04870	COG1263	PTS System
EN12_04870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_04870	COG2190	(PTS) system
EN12_04875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN12_04885	COG0101	tRNA pseudouridine synthase activity
EN12_04890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EN12_04895	COG0285	dihydrofolate synthase activity
EN12_04900	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EN12_04905	COG1286	toxin biosynthetic process
EN12_04910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EN12_04915	COG2056	Na+-H+ antiporter family
EN12_04920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EN12_04940	COG0346	lactoylglutathione lyase activity
EN12_04945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EN12_04950	COG4660	Part of a membrane complex involved in electron transport
EN12_04955	COG4659	FMN binding
EN12_04960	COG4658	electron transport chain
EN12_04965	COG4656	Part of a membrane complex involved in electron transport
EN12_04970	COG2878	Part of a membrane complex involved in electron transport
EN12_04975	COG4657	Part of a membrane complex involved in electron transport
EN12_04990	COG0556	nucleotide-excision repair
EN12_05000	COG2204	response regulator
EN12_05005	COG2198	Histidine kinase
EN12_05010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EN12_05015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EN12_05020	COG0521	Mo-molybdopterin cofactor biosynthetic process
EN12_05025	COG0315	cyclic pyranopterin monophosphate synthase activity
EN12_05030	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EN12_05035	COG0314	molybdopterin synthase activity
EN12_05040	COG2199	diguanylate cyclase activity
EN12_05045	COG4109	DRTGG domain
EN12_05055	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EN12_05065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_05065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_05070	COG0489	protein tyrosine kinase activity
EN12_05080	COG0572	uridine kinase
EN12_05085	COG2982	Protein involved in outer membrane biogenesis
EN12_05090	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EN12_05095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN12_05105	COG2067	long-chain fatty acid transport protein
EN12_05130	COG0183	Belongs to the thiolase family
EN12_05135	COG1024	Enoyl-CoA hydratase
EN12_05135	COG1250	3-hydroxyacyl-CoA dehydrogenase
EN12_05140	COG0778	Nitroreductase
EN12_05145	COG0583	DNA-binding transcription factor activity
EN12_05150	COG0745	RESPONSE REGULATOR receiver
EN12_05160	COG2832	Protein of unknown function (DUF454)
EN12_05165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EN12_05175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EN12_05180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EN12_05195	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_05200	COG0616	signal peptide processing
EN12_05210	COG1522	sequence-specific DNA binding
EN12_05215	COG1946	Acyl-CoA thioesterase
EN12_05235	COG3706	GGDEF domain
EN12_05240	COG0640	Transcriptional regulator
EN12_05245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN12_05270	COG1881	PFAM PEBP family protein
EN12_05290	COG0009	L-threonylcarbamoyladenylate synthase
EN12_05305	COG2201	protein-glutamate methylesterase activity
EN12_05315	COG5002	protein histidine kinase activity
EN12_05320	COG4191	Histidine kinase
EN12_05325	COG5001	Diguanylate cyclase
EN12_05325	COG3300	MHYT domain
EN12_05330	COG2204	response regulator
EN12_05350	COG0601	transmembrane transport
EN12_05355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN12_05360	COG0444	Belongs to the ABC transporter superfamily
EN12_05365	COG4608	Belongs to the ABC transporter superfamily
EN12_05370	COG0435	Glutathione S-transferase
EN12_05375	COG0280	phosphate acetyltransferase
EN12_05375	COG0857	belongs to the CobB CobQ family
EN12_05380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EN12_05385	COG3092	negative regulation of chromosome organization
EN12_05390	COG4628	conserved protein (DUF2132)
EN12_05400	COG4120	Belongs to the binding-protein-dependent transport system permease family
EN12_05410	COG2203	Gaf domain
EN12_05410	COG2199	diguanylate cyclase activity
EN12_05415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN12_05425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EN12_05430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EN12_05435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EN12_05440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EN12_05445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN12_05450	COG0156	8-amino-7-oxononanoate synthase activity
EN12_05455	COG2226	methyltransferase
EN12_05460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EN12_05470	COG0501	Belongs to the peptidase M48B family
EN12_05480	COG0300	oxidoreductase activity
EN12_05495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EN12_05505	COG2268	Band 7 protein
EN12_05515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EN12_05520	COG2915	High frequency lysogenization protein hflD homolog
EN12_05525	COG0482	sulfurtransferase activity
EN12_05530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN12_05540	COG1757	Na H antiporter
EN12_05545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EN12_05550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EN12_05555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EN12_05560	COG0131	Imidazoleglycerol-phosphate dehydratase
EN12_05560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN12_05565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EN12_05570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EN12_05575	COG0107	imidazoleglycerol-phosphate synthase activity
EN12_05580	COG0140	phosphoribosyl-ATP diphosphatase activity
EN12_05580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EN12_05585	COG1187	pseudouridine synthase activity
EN12_05595	COG1278	Cold shock
EN12_05600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EN12_05605	COG0542	response to heat
EN12_05615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN12_05620	COG1454	alcohol dehydrogenase
EN12_05620	COG1012	belongs to the aldehyde dehydrogenase family
EN12_05625	COG1737	Transcriptional regulator
EN12_05630	COG0076	glutamate decarboxylase activity
EN12_05640	COG2431	L-lysine efflux transmembrane transporter activity
EN12_05650	COG3070	regulator of competence-specific genes
EN12_05665	COG3852	Histidine kinase
EN12_05675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EN12_05690	COG0189	ligase activity
EN12_05690	COG4067	protein conserved in archaea
EN12_05695	COG0500	methyltransferase
EN12_05700	COG4106	trans-aconitate 2-methyltransferase activity
EN12_05705	COG1801	Protein of unknown function DUF72
EN12_05710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EN12_05715	COG1435	thymidine kinase activity
EN12_05725	COG0159	tryptophan synthase activity
EN12_05730	COG0133	tryptophan synthase activity
EN12_05735	COG0134	indole-3-glycerol-phosphate synthase activity
EN12_05735	COG0135	phosphoribosylanthranilate isomerase activity
EN12_05740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EN12_05745	COG0512	Glutamine amidotransferase of anthranilate synthase
EN12_05750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN12_05760	COG0613	PHP domain protein
EN12_05765	COG0009	L-threonylcarbamoyladenylate synthase
EN12_05770	COG1187	pseudouridine synthase activity
EN12_05775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EN12_05780	COG4988	ABC transporter
EN12_05785	COG0492	ferredoxin-NADP+ reductase activity
EN12_05800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN12_05805	COG3706	GGDEF domain
EN12_05810	COG2949	membrane
EN12_05820	COG0281	malic enzyme
EN12_05830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EN12_05850	COG2885	chlorophyll binding
EN12_05865	COG0277	FAD linked oxidase domain protein
EN12_05865	COG0247	lactate metabolic process
EN12_05885	COG2986	histidine ammonia-lyase
EN12_05890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EN12_05895	COG0010	Belongs to the arginase family
EN12_05900	COG1228	amidohydrolase
EN12_05920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN12_05930	COG5001	Diguanylate cyclase
EN12_05935	COG0417	DNA replication proofreading
EN12_05940	COG2197	response regulator
EN12_05945	COG0322	excinuclease ABC activity
EN12_05975	COG3706	GGDEF domain
EN12_05975	COG0745	RESPONSE REGULATOR receiver
EN12_05985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EN12_05990	COG0072	phenylalanine-tRNA ligase activity
EN12_05990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_05995	COG0776	regulation of translation
EN12_06010	COG0500	methyltransferase
EN12_06025	COG0295	cytidine deaminase activity
EN12_06030	COG1346	cytolysis
EN12_06040	COG2925	Exonuclease
EN12_06050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_06060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EN12_06065	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EN12_06080	COG2988	succinylglutamate desuccinylase activity
EN12_06085	COG4139	cobalamin transport
EN12_06090	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EN12_06135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN12_06140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN12_06145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN12_06165	COG2814	Major facilitator Superfamily
EN12_06175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EN12_06205	COG3108	Peptidase M15
EN12_06210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN12_06225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN12_06250	COG1846	Transcriptional regulator
EN12_06255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EN12_06260	COG0726	polysaccharide deacetylase
EN12_06265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EN12_06275	COG1447	Phosphotransferase system cellobiose-specific component IIA
EN12_06280	COG1486	melibiose metabolic process
EN12_06285	COG3394	polysaccharide catabolic process
EN12_06290	COG1609	Transcriptional regulator
EN12_06295	COG2943	transferase activity, transferring hexosyl groups
EN12_06300	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EN12_06305	COG0840	transmembrane signaling receptor activity
EN12_06320	COG1448	Aminotransferase
EN12_06330	COG2770	Histidine kinase
EN12_06330	COG3437	response regulator, receiver
EN12_06335	COG0351	phosphomethylpyrimidine kinase
EN12_06340	COG0017	Asparaginyl-tRNA synthetase
EN12_06350	COG0720	synthase
EN12_06355	COG1760	l-serine dehydratase
EN12_06360	COG0814	amino acid
EN12_06365	COG0494	nUDIX hydrolase
EN12_06370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN12_06385	COG3106	COG3106 Predicted ATPase
EN12_06390	COG3768	UPF0283 membrane protein
EN12_06395	COG3283	Transcriptional regulator of aromatic amino acids metabolism
EN12_06400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN12_06415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN12_06425	COG0471	metal ion transport
EN12_06430	COG4191	Histidine kinase
EN12_06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN12_06440	COG2990	Protein conserved in bacteria
EN12_06445	COG3713	MltA-interacting MipA family protein
EN12_06450	COG2205	protein histidine kinase activity
EN12_06455	COG0745	RESPONSE REGULATOR receiver
EN12_06480	COG1129	ABC transporter
EN12_06515	COG2186	Transcriptional regulator
EN12_06520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EN12_06525	COG0372	Belongs to the citrate synthase family
EN12_06555	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN12_06570	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EN12_06580	COG0625	glutathione transferase activity
EN12_06585	COG3437	response regulator, receiver
EN12_06600	COG3706	GGDEF domain
EN12_06605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN12_06610	COG1254	Belongs to the acylphosphatase family
EN12_06615	COG2920	part of a sulfur-relay system
EN12_06620	COG0670	Belongs to the BI1 family
EN12_06625	COG1126	abc transporter atp-binding protein
EN12_06630	COG0765	amino acid transport
EN12_06635	COG4597	amino acid ABC transporter
EN12_06640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN12_06650	COG0561	phosphatase activity
EN12_06655	COG0602	queuosine metabolic process
EN12_06660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EN12_06690	COG3706	GGDEF domain
EN12_06695	COG0443	Heat shock 70 kDa protein
EN12_06700	COG0443	Heat shock 70 kDa protein
EN12_06730	COG1643	Atp-dependent helicase
EN12_06740	COG0443	Heat shock 70 kDa protein
EN12_06745	COG0095	Lipoate-protein ligase
EN12_06750	COG0583	DNA-binding transcription factor activity
EN12_06755	COG0477	Major facilitator Superfamily
EN12_06760	COG0415	Belongs to the DNA photolyase family
EN12_06765	COG2076	Multidrug Resistance protein
EN12_06785	COG0643	Histidine kinase
EN12_06785	COG2198	Histidine kinase
EN12_06795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN12_06805	COG2201	protein-glutamate methylesterase activity
EN12_06810	COG0835	chemotaxis
EN12_06815	COG3290	protein histidine kinase activity
EN12_06815	COG0840	transmembrane signaling receptor activity
EN12_06820	COG0840	transmembrane signaling receptor activity
EN12_06830	COG0513	Belongs to the DEAD box helicase family
EN12_06840	COG1538	Outer membrane efflux protein
EN12_06845	COG1566	PFAM secretion protein HlyD family protein
EN12_06850	COG2814	Major facilitator Superfamily
EN12_06855	COG0840	transmembrane signaling receptor activity
EN12_06860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EN12_06870	COG3501	Rhs element vgr protein
EN12_06895	COG1280	lysine exporter protein (LysE YggA)
EN12_06900	COG1115	amino acid carrier protein
EN12_06915	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN12_06920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN12_06925	COG1177	transmembrane transport
EN12_06930	COG1176	ABC-type spermidine putrescine transport system, permease component I
EN12_06935	COG3842	ATPase activity
EN12_06955	COG0037	tRNA processing
EN12_06960	COG0589	response to stress
EN12_06965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EN12_06980	COG2217	Heavy metal translocating P-type atpase
EN12_06990	COG2010	Cytochrome c
EN12_07005	COG3278	Belongs to the heme-copper respiratory oxidase family
EN12_07020	COG2205	protein histidine kinase activity
EN12_07020	COG0784	Response regulator, receiver
EN12_07045	COG2994	toxin metabolic process
EN12_07050	COG1073	alpha beta
EN12_07050	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN12_07050	COG3064	Membrane
EN12_07065	COG4128	Pfam Zonular occludens toxin
EN12_07100	COG1476	TRANSCRIPTIONal
EN12_07120	COG1476	TRANSCRIPTIONal
EN12_07205	COG3120	sequence-specific DNA binding
EN12_07210	COG1067	ATP-dependent peptidase activity
EN12_07215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN12_07235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN12_07235	COG0116	Belongs to the methyltransferase superfamily
EN12_07245	COG0167	dihydroorotate dehydrogenase activity
EN12_07260	COG0308	aminopeptidase N
EN12_07275	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EN12_07280	COG1956	GAF domain-containing protein
EN12_07285	COG1132	(ABC) transporter
EN12_07290	COG2995	paraquat-inducible protein a
EN12_07295	COG3008	intermembrane lipid transfer
EN12_07300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EN12_07300	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EN12_07305	COG2996	Protein conserved in bacteria
EN12_07320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN12_07330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EN12_07345	COG0437	4 iron, 4 sulfur cluster binding
EN12_07350	COG3383	formate dehydrogenase (NAD+) activity
EN12_07350	COG0243	molybdopterin cofactor binding
EN12_07380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EN12_07385	COG0488	(ABC) transporter
EN12_07390	COG3852	Histidine kinase
EN12_07395	COG2204	response regulator
EN12_07405	COG4662	Binding-protein-dependent transport system inner membrane component
EN12_07410	COG3842	ATPase activity
EN12_07415	COG0746	molybdenum cofactor guanylyltransferase activity
EN12_07445	COG1940	carbohydrate kinase activity
EN12_07460	COG0840	transmembrane signaling receptor activity
EN12_07465	COG0791	NLP P60 protein
EN12_07485	COG0534	Mate efflux family protein
EN12_07495	COG1793	dna ligase
EN12_07505	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EN12_07510	COG0848	biopolymer transport protein
EN12_07515	COG0811	peptide transport
EN12_07520	COG0811	peptide transport
EN12_07535	COG1175	transmembrane transport
EN12_07540	COG0395	ABC-type sugar transport system, permease component
EN12_07545	COG3842	ATPase activity
EN12_07550	COG1349	DNA-binding transcription factor activity
EN12_07555	COG0584	glycerophosphoryl diester phosphodiesterase
EN12_07560	COG2731	YhcH YjgK YiaL family protein
EN12_07565	COG0251	oxidation-reduction process
EN12_07570	COG1609	Transcriptional regulator
EN12_07575	COG2723	6-phospho-beta-galactosidase activity
EN12_07580	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EN12_07585	COG0583	DNA-binding transcription factor activity
EN12_07605	COG0577	efflux transmembrane transporter activity
EN12_07605	COG1136	(ABC) transporter
EN12_07610	COG0577	efflux transmembrane transporter activity
EN12_07610	COG1136	(ABC) transporter
EN12_07615	COG1136	(ABC) transporter
EN12_07615	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN12_07620	COG1294	oxidase, subunit
EN12_07625	COG1271	oxidase subunit
EN12_07665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN12_07675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EN12_07695	COG0753	catalase activity
EN12_07725	COG2199	diguanylate cyclase activity
EN12_07725	COG2200	EAL domain
EN12_07730	COG3706	GGDEF domain
EN12_07735	COG2017	converts alpha-aldose to the beta-anomer
EN12_07740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EN12_07745	COG1085	galactose-1-phosphate uridylyltransferase
EN12_07775	COG3706	GGDEF domain
EN12_07775	COG0745	RESPONSE REGULATOR receiver
EN12_07790	COG0835	chemotaxis
EN12_07790	COG0784	Response regulator, receiver
EN12_07800	COG4565	transcriptional regulatory protein
EN12_07805	COG3290	protein histidine kinase activity
EN12_07820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_07840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EN12_07845	COG3063	Type IV pilus biogenesis stability protein PilW
EN12_07855	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EN12_07860	COG1451	nucleotide metabolic process
EN12_07870	COG0583	DNA-binding transcription factor activity
EN12_07890	COG1538	Outer membrane efflux protein
EN12_07900	COG0019	diaminopimelate decarboxylase activity
EN12_07905	COG1748	Saccharopine dehydrogenase
EN12_07915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN12_07930	COG4181	ATPase activity
EN12_07935	COG0534	Mate efflux family protein
EN12_07940	COG0702	epimerase
EN12_07950	COG2814	Major facilitator Superfamily
EN12_07955	COG1187	pseudouridine synthase activity
EN12_07960	COG1061	Type III restriction enzyme res subunit
EN12_07980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EN12_07985	COG2203	Gaf domain
EN12_07985	COG5001	Diguanylate cyclase
EN12_07985	COG3706	GGDEF domain
EN12_07985	COG4251	negative regulation of phosphorylation
EN12_08000	COG0840	transmembrane signaling receptor activity
EN12_08030	COG4934	collagen metabolic process
EN12_08050	COG2239	Acts as a magnesium transporter
EN12_08065	COG0814	amino acid
EN12_08070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_08075	COG1131	(ABC) transporter
EN12_08080	COG0842	Transport permease protein
EN12_08090	COG3313	Fe-S protein
EN12_08100	COG4134	Bacterial extracellular solute-binding protein
EN12_08105	COG4135	transport system, permease component
EN12_08110	COG4136	ATPase activity
EN12_08115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EN12_08120	COG0564	pseudouridine synthase activity
EN12_08125	COG0733	neurotransmitter:sodium symporter activity
EN12_08135	COG0626	cystathionine gamma-synthase activity
EN12_08140	COG2818	Glycosylase
EN12_08155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_08170	COG1842	Phage shock protein A
EN12_08175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EN12_08185	COG4168	peptide transport system, permease
EN12_08190	COG4171	peptide transport system, permease
EN12_08200	COG4172	Belongs to the ABC transporter superfamily
EN12_08215	COG1227	inorganic diphosphatase activity
EN12_08235	COG0243	molybdopterin cofactor binding
EN12_08240	COG3005	denitrification pathway
EN12_08245	COG4459	periplasmic nitrate reductase
EN12_08255	COG2116	formate transmembrane transporter activity
EN12_08265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN12_08270	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN12_08280	COG2917	probably involved in intracellular septation
EN12_08285	COG1607	acyl-coa hydrolase
EN12_08290	COG2350	Protein conserved in bacteria
EN12_08300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EN12_08320	COG0612	Peptidase, M16
EN12_08325	COG5001	Diguanylate cyclase
EN12_08330	COG1032	radical SAM domain protein
EN12_08345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EN12_08350	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EN12_08355	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EN12_08360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN12_08365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN12_08370	COG0745	RESPONSE REGULATOR receiver
EN12_08375	COG3381	protein complex oligomerization
EN12_08380	COG1609	Transcriptional regulator
EN12_08385	COG3070	regulator of competence-specific genes
EN12_08405	COG0297	glycogen (starch) synthase activity
EN12_08410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EN12_08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN12_08425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EN12_08435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EN12_08440	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EN12_08445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EN12_08450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EN12_08475	COG1012	belongs to the aldehyde dehydrogenase family
EN12_08480	COG1309	transcriptional regulator
EN12_08500	COG0668	transmembrane transport
EN12_08505	COG2995	paraquat-inducible protein a
EN12_08510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN12_08510	COG3008	intermembrane lipid transfer
EN12_08520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_08535	COG0582	viral genome integration into host DNA
EN12_08545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EN12_08565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EN12_08585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EN12_08605	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN12_08610	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN12_08615	COG1737	Transcriptional regulator
EN12_08620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EN12_08625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN12_08630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN12_08635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN12_08640	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EN12_08645	COG1940	carbohydrate kinase activity
EN12_08650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN12_08655	COG4409	exo-alpha-(2->6)-sialidase activity
EN12_08665	COG2003	Belongs to the UPF0758 family
EN12_08690	COG3941	tape measure
EN12_08730	COG0488	(ABC) transporter
EN12_08810	COG0415	Belongs to the DNA photolyase family
EN12_08820	COG4628	conserved protein (DUF2132)
EN12_08825	COG3284	Transcriptional regulator
EN12_08830	COG1012	belongs to the aldehyde dehydrogenase family
EN12_08840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_08845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_08850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_08860	COG2207	Transcriptional regulator
EN12_08865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_08865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_08865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_08870	COG1482	cell wall glycoprotein biosynthetic process
EN12_08880	COG0784	Response regulator, receiver
EN12_08880	COG5002	protein histidine kinase activity
EN12_08890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EN12_08900	COG2885	chlorophyll binding
EN12_08905	COG0823	Involved in the tonB-independent uptake of proteins
EN12_08920	COG0811	peptide transport
EN12_08925	COG0824	Thioesterase
EN12_08930	COG3790	cyd operon protein YbgE
EN12_08935	COG4890	Cyd operon protein YbgT
EN12_08940	COG1294	oxidase, subunit
EN12_08945	COG1271	oxidase subunit
EN12_08950	COG2255	four-way junction helicase activity
EN12_08955	COG0632	four-way junction helicase activity
EN12_08960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EN12_08965	COG0215	cysteine-tRNA ligase activity
EN12_08970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN12_08975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_08980	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN12_08990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EN12_08995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN12_09000	COG1199	ATP-dependent helicase activity
EN12_09005	COG0730	response to heat
EN12_09010	COG3923	Primosomal replication protein n
EN12_09020	COG0840	transmembrane signaling receptor activity
EN12_09025	COG0708	Exodeoxyribonuclease III
EN12_09030	COG4160	amino acid transport
EN12_09035	COG4215	(ABC) transporter
EN12_09060	COG1882	Formate acetyltransferase
EN12_09070	COG0840	transmembrane signaling receptor activity
EN12_09075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EN12_09085	COG3013	Belongs to the UPF0304 family
EN12_09090	COG2766	serine protein kinase
EN12_09095	COG2718	Belongs to the UPF0229 family
EN12_09100	COG2719	SpoVR family
EN12_09105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EN12_09115	COG1663	tetraacyldisaccharide 4'-kinase activity
EN12_09120	COG1132	(ABC) transporter
EN12_09125	COG0658	competence protein
EN12_09125	COG2333	competence protein COMEC
EN12_09135	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN12_09140	COG1136	(ABC) transporter
EN12_09145	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN12_09155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EN12_09175	COG1252	NADH dehydrogenase
EN12_09205	COG0537	adenosine 5'-monophosphoramidase activity
EN12_09220	COG2186	Transcriptional regulator
EN12_09225	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN12_09230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EN12_09235	COG1674	ftsk spoiiie
EN12_09245	COG0686	Belongs to the AlaDH PNT family
EN12_09255	COG0583	DNA-binding transcription factor activity
EN12_09275	COG0284	orotidine-5'-phosphate decarboxylase activity
EN12_09280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EN12_09285	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EN12_09290	COG0776	regulation of translation
EN12_09295	COG0539	negative regulation of cytoplasmic translation
EN12_09300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EN12_09305	COG1555	photosystem II stabilization
EN12_09310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN12_09315	COG0776	regulation of translation
EN12_09320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EN12_09325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EN12_09335	COG0544	peptidyl-prolyl cis-trans isomerase activity
EN12_09345	COG4191	Histidine kinase
EN12_09355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN12_09360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN12_09365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN12_09370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EN12_09385	COG5001	Diguanylate cyclase
EN12_09385	COG3300	MHYT domain
EN12_09395	COG4589	Belongs to the CDS family
EN12_09430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EN12_09440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_09460	COG0243	molybdopterin cofactor binding
EN12_09465	COG3005	denitrification pathway
EN12_09470	COG3325	Belongs to the glycosyl hydrolase 18 family
EN12_09470	COG3469	chitinase activity
EN12_09475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN12_09490	COG2951	lytic endotransglycosylase activity
EN12_09495	COG3100	YcgL domain-containing protein
EN12_09500	COG0850	regulation of cytokinetic process
EN12_09505	COG2894	cell division
EN12_09510	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EN12_09515	COG3015	lipoprotein NlpE involved in copper resistance
EN12_09535	COG0477	Major facilitator Superfamily
EN12_09545	COG0840	transmembrane signaling receptor activity
EN12_09550	COG1396	sequence-specific DNA binding
EN12_09555	COG3135	benzoate transporter
EN12_09565	COG1441	menaquinone biosynthetic process
EN12_09575	COG0596	Alpha beta hydrolase
EN12_09580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EN12_09585	COG1169	isochorismate synthase
EN12_09590	COG0436	Aminotransferase
EN12_09595	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EN12_09600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EN12_09620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EN12_09625	COG0318	PFAM AMP-dependent synthetase and ligase
EN12_09630	COG0596	Alpha beta hydrolase
EN12_09645	COG1214	PFAM Peptidase M22, glycoprotease
EN12_09650	COG1199	ATP-dependent helicase activity
EN12_09660	COG0788	formyltetrahydrofolate deformylase activity
EN12_09665	COG1902	pentaerythritol trinitrate reductase activity
EN12_09665	COG0446	pyridine nucleotide-disulphide oxidoreductase
EN12_09670	COG0616	signal peptide processing
EN12_09675	COG0252	asparaginase activity
EN12_09680	COG3139	Protein of unknown function (DUF1315)
EN12_09690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_09695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN12_09700	COG0676	glucose-6-phosphate 1-epimerase activity
EN12_09710	COG2226	methyltransferase
EN12_09725	COG0835	chemotaxis
EN12_09725	COG0784	Response regulator, receiver
EN12_09730	COG1940	carbohydrate kinase activity
EN12_09740	COG4667	esterase of the alpha-beta hydrolase superfamily
EN12_09755	COG0733	neurotransmitter:sodium symporter activity
EN12_09765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_09765	COG1263	PTS System
EN12_09770	COG0084	hydrolase, TatD family'
EN12_09780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EN12_09785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EN12_09790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN12_09795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN12_09800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EN12_09805	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_09810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EN12_09815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EN12_09820	COG0416	fatty acid biosynthetic process
EN12_09825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EN12_09830	COG1399	metal-binding, possibly nucleic acid-binding protein
EN12_09835	COG0424	maF-like protein
EN12_09840	COG0564	pseudouridine synthase activity
EN12_09850	COG1530	ribonuclease E activity
EN12_09855	COG0659	secondary active sulfate transmembrane transporter activity
EN12_09865	COG1012	belongs to the aldehyde dehydrogenase family
EN12_09865	COG1454	alcohol dehydrogenase
EN12_09870	COG2095	MarC family integral membrane protein
EN12_09875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN12_09880	COG1757	Na H antiporter
EN12_09890	COG3081	Nucleoid-associated protein
EN12_09900	COG3083	sulfuric ester hydrolase activity
EN12_09920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN12_09925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EN12_09945	COG2853	Lipoprotein
EN12_09955	COG4235	cytochrome complex assembly
EN12_09955	COG3088	subunit of a heme lyase
EN12_09960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EN12_09965	COG1138	Cytochrome C-type biogenesis protein
EN12_09970	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EN12_09980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN12_09985	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN12_09990	COG4133	protoheme IX ABC transporter activity
EN12_10000	COG0835	chemotaxis
EN12_10010	COG1192	Involved in chromosome partitioning
EN12_10015	COG2201	protein-glutamate methylesterase activity
EN12_10020	COG2198	Histidine kinase
EN12_10020	COG0643	Histidine kinase
EN12_10025	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EN12_10040	COG0455	bacterial-type flagellum organization
EN12_10055	COG2062	phosphohistidine phosphatase, SixA
EN12_10060	COG1025	Belongs to the peptidase M16 family
EN12_10070	COG0018	arginyl-trna synthetase
EN12_10090	COG1918	ferrous iron import across plasma membrane
EN12_10095	COG4977	sequence-specific DNA binding
EN12_10100	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EN12_10105	COG1121	(ABC) transporter
EN12_10110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EN12_10120	COG0045	succinate-CoA ligase (ADP-forming) activity
EN12_10125	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN12_10130	COG0567	Dehydrogenase, E1 component
EN12_10140	COG1053	succinate dehydrogenase
EN12_10145	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EN12_10150	COG2009	succinate dehydrogenase
EN12_10155	COG0372	Belongs to the citrate synthase family
EN12_10160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EN12_10170	COG0033	Phosphoglucomutase
EN12_10175	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EN12_10180	COG0596	Alpha beta hydrolase
EN12_10195	COG1346	cytolysis
EN12_10205	COG0583	DNA-binding transcription factor activity
EN12_10215	COG0735	belongs to the Fur family
EN12_10220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN12_10225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN12_10230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN12_10235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EN12_10235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EN12_10240	COG0431	NADPH-dependent FMN reductase
EN12_10250	COG3101	peptidyl-lysine hydroxylation
EN12_10255	COG2860	membrane
EN12_10260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EN12_10265	COG2890	protein-(glutamine-N5) methyltransferase activity
EN12_10275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EN12_10280	COG1684	flagellar biosynthetic protein fliR
EN12_10285	COG1987	bacterial-type flagellum assembly
EN12_10310	COG1580	Controls the rotational direction of flagella during chemotaxis
EN12_10330	COG1317	bacterial-type flagellum organization
EN12_10335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EN12_10345	COG1677	Flagellar hook-basal body complex protein FliE
EN12_10350	COG2204	response regulator
EN12_10355	COG4191	Histidine kinase
EN12_10360	COG2204	response regulator
EN12_10365	COG1516	flagellar protein fliS
EN12_10375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EN12_10380	COG1334	flagellar protein FlaG
EN12_10385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_10390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_10395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_10400	COG2837	iron assimilation
EN12_10420	COG1393	Belongs to the ArsC family
EN12_10425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EN12_10430	COG1876	peptidase activity
EN12_10440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EN12_10445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EN12_10455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EN12_10475	COG4783	chaperone-mediated protein folding
EN12_10480	COG1393	Belongs to the ArsC family
EN12_10500	COG2233	PERMEase
EN12_10505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EN12_10510	COG0737	Belongs to the 5'-nucleotidase family
EN12_10515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EN12_10520	COG2912	Transglutaminase-like superfamily
EN12_10525	COG3094	Invasion gene expression up-regulator, SirB
EN12_10530	COG2890	protein-(glutamine-N5) methyltransferase activity
EN12_10535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EN12_10540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EN12_10545	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EN12_10550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EN12_10555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EN12_10560	COG0193	aminoacyl-tRNA hydrolase activity
EN12_10565	COG0012	GTP binding
EN12_10650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_10655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_10670	COG1705	Flagellar rod assembly protein muramidase FlgJ
EN12_10670	COG3951	Flagellar rod assembly protein muramidase FlgJ
EN12_10675	COG1706	bacterial-type flagellum-dependent cell motility
EN12_10680	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EN12_10685	COG4786	Flagellar basal body rod
EN12_10690	COG4787	bacterial-type flagellum-dependent cell motility
EN12_10695	COG1749	Flagellar hook protein flgE
EN12_10700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EN12_10705	COG1558	bacterial-type flagellum-dependent cell motility
EN12_10710	COG1815	bacterial-type flagellum-dependent cell motility
EN12_10715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN12_10720	COG0835	chemotaxis
EN12_10720	COG0784	Response regulator, receiver
EN12_10755	COG3433	isochorismatase activity
EN12_10755	COG2226	methyltransferase
EN12_10755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN12_10760	COG2375	cellular response to nickel ion
EN12_10765	COG1629	transport
EN12_10765	COG4774	siderophore transport
EN12_10780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN12_10785	COG2217	Heavy metal translocating P-type atpase
EN12_10785	COG2608	mercury ion transmembrane transporter activity
EN12_10800	COG3735	TraB family
EN12_10815	COG2840	Smr protein MutS2
EN12_10820	COG1187	pseudouridine synthase activity
EN12_10825	COG3706	GGDEF domain
EN12_10830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EN12_10835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EN12_10840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EN12_10845	COG0121	glutamine amidotransferase
EN12_10850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN12_10855	COG1960	acyl-CoA dehydrogenase activity
EN12_10865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EN12_10870	COG0328	RNA-DNA hybrid ribonuclease activity
EN12_10875	COG2226	methyltransferase
EN12_10880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN12_10885	COG0741	lytic transglycosylase activity
EN12_10885	COG1388	LysM domain
EN12_10895	COG0347	Belongs to the P(II) protein family
EN12_10900	COG3479	Phenolic acid decarboxylase
EN12_10910	COG0037	tRNA processing
EN12_10915	COG0825	malonyl-CoA metabolic process
EN12_10920	COG0587	DNA-directed DNA polymerase activity
EN12_10925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EN12_10930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_10935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_10940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN12_10945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_10950	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EN12_10960	COG0750	zinc metalloprotease
EN12_10965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EN12_10970	COG0575	Belongs to the CDS family
EN12_10975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EN12_10980	COG0233	cytoplasmic translational termination
EN12_10985	COG0528	UMP kinase activity
EN12_10990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EN12_10995	COG0052	Belongs to the universal ribosomal protein uS2 family
EN12_11000	COG0024	Methionine aminopeptidase
EN12_11005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EN12_11015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EN12_11020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EN12_11025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN12_11030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EN12_11045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN12_11045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN12_11050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EN12_11055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EN12_11060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EN12_11075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EN12_11080	COG2252	PERMEase
EN12_11085	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN12_11090	COG0189	ligase activity
EN12_11090	COG4067	protein conserved in archaea
EN12_11095	COG0189	ligase activity
EN12_11105	COG0733	neurotransmitter:sodium symporter activity
EN12_11110	COG3706	GGDEF domain
EN12_11115	COG3328	transposase activity
EN12_11135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EN12_11145	COG1477	protein flavinylation
EN12_11150	COG2871	sodium ion transport
EN12_11155	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_11160	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_11165	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_11170	COG1805	sodium ion transport
EN12_11175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_11180	COG0271	Belongs to the BolA IbaG family
EN12_11185	COG2813	Specifically methylates the guanine in position
EN12_11195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN12_11200	COG2211	Major facilitator Superfamily
EN12_11210	COG1595	DNA-templated transcription, initiation
EN12_11220	COG3248	Nucleoside-binding outer membrane protein
EN12_11225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EN12_11230	COG0693	protein deglycase activity
EN12_11235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN12_11240	COG2166	iron-sulfur cluster assembly
EN12_11245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EN12_11250	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EN12_11260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN12_11260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EN12_11275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EN12_11280	COG1074	ATP-dependent DNA helicase activity
EN12_11285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EN12_11300	COG3141	response to X-ray
EN12_11305	COG2171	N-acyltransferase activity
EN12_11315	COG0456	acetyltransferase
EN12_11325	COG0189	ligase activity
EN12_11325	COG0569	domain protein
EN12_11340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_11345	COG1609	Transcriptional regulator
EN12_11350	COG3250	beta-galactosidase activity
EN12_11365	COG1022	Amp-dependent synthetase and ligase
EN12_11370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN12_11375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EN12_11385	COG0560	Phosphoserine phosphatase
EN12_11395	COG0813	purine-nucleoside phosphorylase activity
EN12_11400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EN12_11405	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EN12_11410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EN12_11415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN12_11420	COG0084	hydrolase, TatD family'
EN12_11430	COG1115	amino acid carrier protein
EN12_11445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EN12_11450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EN12_11455	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EN12_11460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EN12_11465	COG0083	homoserine kinase activity
EN12_11480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN12_11490	COG0745	RESPONSE REGULATOR receiver
EN12_11495	COG5002	protein histidine kinase activity
EN12_11495	COG2198	Histidine kinase
EN12_11495	COG0784	Response regulator, receiver
EN12_11500	COG5001	Diguanylate cyclase
EN12_11500	COG2203	Gaf domain
EN12_11500	COG3706	GGDEF domain
EN12_11500	COG4251	negative regulation of phosphorylation
EN12_11505	COG1242	4 iron, 4 sulfur cluster binding
EN12_11510	COG0069	glutamate synthase activity
EN12_11510	COG0070	glutamate synthase
EN12_11510	COG0067	glutamate synthase
EN12_11520	COG0070	glutamate synthase
EN12_11520	COG0067	glutamate synthase
EN12_11520	COG0069	glutamate synthase activity
EN12_11525	COG0493	'glutamate synthase
EN12_11535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EN12_11545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EN12_11550	COG2860	membrane
EN12_11555	COG0583	DNA-binding transcription factor activity
EN12_11560	COG0730	response to heat
EN12_11590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EN12_11595	COG0505	Belongs to the CarA family
EN12_11605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EN12_11610	COG0494	nUDIX hydrolase
EN12_11615	COG0653	protein targeting
EN12_11625	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EN12_11630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EN12_11635	COG0849	cell division
EN12_11640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EN12_11645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN12_11650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EN12_11655	COG0772	Belongs to the SEDS family
EN12_11660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EN12_11665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EN12_11670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EN12_11675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EN12_11680	COG0768	penicillin binding
EN12_11685	COG3116	cell division
EN12_11690	COG0275	rRNA processing
EN12_11695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_11700	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN12_11705	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EN12_11710	COG2186	Transcriptional regulator
EN12_11715	COG0737	Belongs to the 5'-nucleotidase family
EN12_11720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EN12_11725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN12_11730	COG4974	Belongs to the 'phage' integrase family
EN12_11735	COG0716	FMN binding
EN12_11755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_11760	COG1459	type II secretion system
EN12_11770	COG0237	dephospho-CoA kinase activity
EN12_11775	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EN12_11785	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EN12_11790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EN12_11795	COG0187	DNA topoisomerase II activity
EN12_11800	COG3150	esterase
EN12_11810	COG3151	Protein conserved in bacteria
EN12_11815	COG0494	nUDIX hydrolase
EN12_11820	COG1538	Outer membrane efflux protein
EN12_11830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EN12_11835	COG0840	transmembrane signaling receptor activity
EN12_11845	COG3025	triphosphatase activity
EN12_11850	COG1392	Phosphate transport regulator
EN12_11855	COG0306	phosphate transporter
EN12_11860	COG4991	sh3 domain protein
EN12_11870	COG3267	Type II secretory pathway component ExeA
EN12_11870	COG3409	Peptidoglycan-binding domain 1 protein
EN12_11875	COG0617	tRNA 3'-terminal CCA addition
EN12_11880	COG0148	phosphopyruvate hydratase activity
EN12_11885	COG0504	CTP synthase activity
EN12_11890	COG3956	TIGRFAM MazG family protein
EN12_11895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN12_11900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN12_11910	COG5001	Diguanylate cyclase
EN12_11925	COG0736	holo-[acyl-carrier-protein] synthase activity
EN12_11930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EN12_11935	COG1381	Involved in DNA repair and RecF pathway recombination
EN12_11940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EN12_11945	COG0571	ribonuclease III activity
EN12_11950	COG0681	Belongs to the peptidase S26 family
EN12_11955	COG0481	GTPase activity
EN12_11960	COG3086	response to oxidative stress
EN12_11965	COG3026	antisigma factor binding
EN12_11975	COG1595	DNA-templated transcription, initiation
EN12_11980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EN12_11990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EN12_11995	COG0354	folic acid binding
EN12_12005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_12010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_12020	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EN12_12025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EN12_12030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EN12_12035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN12_12040	COG0440	acetolactate synthase activity
EN12_12045	COG0028	Belongs to the TPP enzyme family
EN12_12050	COG1022	Amp-dependent synthetase and ligase
EN12_12055	COG0583	DNA-binding transcription factor activity
EN12_12075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EN12_12080	COG0473	3-isopropylmalate dehydrogenase activity
EN12_12085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EN12_12090	COG0066	3-isopropylmalate dehydratase activity
EN12_12135	COG3437	response regulator, receiver
EN12_12150	COG0795	lipopolysaccharide-transporting ATPase activity
EN12_12155	COG0795	lipopolysaccharide-transporting ATPase activity
EN12_12160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN12_12165	COG2927	DNA polymerase III (CHI subunit)
EN12_12170	COG0525	valine-tRNA ligase activity
EN12_12175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EN12_12180	COG0564	pseudouridine synthase activity
EN12_12185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EN12_12195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EN12_12200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EN12_12210	COG0540	Belongs to the ATCase OTCase family
EN12_12215	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EN12_12220	COG0251	oxidation-reduction process
EN12_12225	COG0204	Acyl-transferase
EN12_12230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EN12_12235	COG5007	Belongs to the BolA IbaG family
EN12_12245	COG2854	intermembrane phospholipid transfer
EN12_12250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN12_12255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EN12_12260	COG1127	ABC transporter
EN12_12270	COG0517	IMP dehydrogenase activity
EN12_12270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EN12_12285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EN12_12290	COG1137	ATPase activity
EN12_12300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN12_12305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_12310	COG1660	Displays ATPase and GTPase activities
EN12_12315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_12320	COG2239	Acts as a magnesium transporter
EN12_12325	COG0312	modulator of DNA gyrase
EN12_12330	COG3028	Belongs to the UPF0307 family
EN12_12335	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EN12_12340	COG1178	ABC-type Fe3 transport system permease component
EN12_12345	COG4143	(ABC) transporter
EN12_12350	COG0163	prenyltransferase activity
EN12_12355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN12_12360	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EN12_12365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EN12_12370	COG2105	PFAM AIG2 family protein
EN12_12380	COG0729	surface antigen
EN12_12385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_12390	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EN12_12405	COG1136	(ABC) transporter
EN12_12425	COG0529	Catalyzes the synthesis of activated sulfate
EN12_12430	COG2895	sulfate adenylyltransferase (ATP) activity
EN12_12435	COG0175	sulfate reduction
EN12_12440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EN12_12440	COG1648	precorrin-2 dehydrogenase activity
EN12_12455	COG0513	Belongs to the DEAD box helicase family
EN12_12460	COG2153	protein acetylation
EN12_12465	COG0697	spore germination
EN12_12470	COG3061	Opacity-associated protein A
EN12_12470	COG3266	domain, Protein
EN12_12475	COG0545	Peptidyl-prolyl cis-trans isomerase
EN12_12485	COG0203	ribosomal protein L17
EN12_12490	COG0202	RNA polymerase activity
EN12_12495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EN12_12500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EN12_12505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EN12_12515	COG0201	protein transport
EN12_12520	COG0200	Binds to the 23S rRNA
EN12_12525	COG1841	ribosomal large subunit assembly
EN12_12530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EN12_12535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EN12_12540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EN12_12545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EN12_12550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EN12_12555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EN12_12560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EN12_12565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EN12_12570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EN12_12575	COG0255	Belongs to the universal ribosomal protein uL29 family
EN12_12580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EN12_12585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EN12_12590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EN12_12595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EN12_12600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EN12_12605	COG0089	rRNA binding
EN12_12610	COG0088	Forms part of the polypeptide exit tunnel
EN12_12615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EN12_12620	COG0051	transcription antitermination factor activity, RNA binding
EN12_12625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN12_12630	COG0557	exoribonuclease II activity
EN12_12635	COG3083	sulfuric ester hydrolase activity
EN12_12640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EN12_12645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EN12_12655	COG1047	Peptidyl-prolyl cis-trans
EN12_12670	COG2249	NAD(P)H dehydrogenase (quinone) activity
EN12_12675	COG0488	(ABC) transporter
EN12_12685	COG0429	hydrolase of the alpha beta-hydrolase fold
EN12_12695	COG3954	Phosphoribulokinase
EN12_12700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EN12_12710	COG1012	belongs to the aldehyde dehydrogenase family
EN12_12720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EN12_12730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN12_12745	COG0180	Tryptophanyl-tRNA synthetase
EN12_12750	COG0546	phosphoglycolate phosphatase activity
EN12_12755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EN12_12760	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EN12_12770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EN12_12775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EN12_12805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EN12_12815	COG0678	peroxiredoxin activity
EN12_12815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN12_12820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_12830	COG0165	Argininosuccinate lyase
EN12_12835	COG0137	argininosuccinate synthase activity
EN12_12840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN12_12845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EN12_12850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EN12_12855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EN12_12865	COG1045	serine acetyltransferase
EN12_12870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EN12_12875	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EN12_12880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN12_12885	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EN12_12890	COG1053	succinate dehydrogenase
EN12_12895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EN12_12900	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EN12_12905	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EN12_12910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN12_12915	COG1509	lysine 2,3-aminomutase activity
EN12_12925	COG0459	protein refolding
EN12_12930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EN12_12955	COG0149	triose-phosphate isomerase activity
EN12_12965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN12_12970	COG1575	Belongs to the MenA family. Type 1 subfamily
EN12_12975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EN12_12980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EN12_12985	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN12_12990	COG1609	Transcriptional regulator
EN12_12995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EN12_13000	COG0254	rRNA binding
EN12_13005	COG0281	malic enzyme
EN12_13010	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EN12_13015	COG0626	cystathionine gamma-synthase activity
EN12_13020	COG0460	homoserine dehydrogenase
EN12_13020	COG0527	aspartate kinase activity
EN12_13030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EN12_13035	COG3074	FtsZ-dependent cytokinesis
EN12_13040	COG1494	fructose-1,6-bisphosphatase
EN12_13045	COG0205	6-phosphofructokinase activity
EN12_13050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EN12_13060	COG0745	RESPONSE REGULATOR receiver
EN12_13065	COG2205	protein histidine kinase activity
EN12_13075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EN12_13080	COG3030	protein affecting phage T7 exclusion by the F plasmid
EN12_13085	COG3706	GGDEF domain
EN12_13090	COG1027	Aspartate ammonia-lyase
EN12_13095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EN12_13110	COG4232	protein-disulfide reductase activity
EN12_13120	COG3263	regulation of cellular component size
EN12_13130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EN12_13135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EN12_13140	COG0194	GDP metabolic process
EN12_13145	COG1758	RNA polymerase activity
EN12_13150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN12_13155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EN12_13160	COG2233	PERMEase
EN12_13170	COG0745	RESPONSE REGULATOR receiver
EN12_13175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN12_13180	COG2183	response to ionizing radiation
EN12_13190	COG0596	Alpha beta hydrolase
EN12_13195	COG1040	competence protein
EN12_13200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EN12_13200	COG0316	Belongs to the HesB IscA family
EN12_13205	COG0494	nUDIX hydrolase
EN12_13210	COG1218	3'(2'),5'-bisphosphate nucleotidase
EN12_13220	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN12_13225	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN12_13230	COG3156	type II secretion system protein K
EN12_13235	COG4795	General secretion pathway protein
EN12_13240	COG2165	general secretion pathway protein
EN12_13245	COG2165	general secretion pathway protein
EN12_13250	COG2165	general secretion pathway protein
EN12_13255	COG1459	type II secretion system
EN12_13260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_13270	COG3031	protein transport across the cell outer membrane
EN12_13275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EN12_13280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EN12_13285	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EN12_13295	COG0456	acetyltransferase
EN12_13300	COG1490	D-aminoacyl-tRNA deacylase activity
EN12_13325	COG0174	glutamine synthetase
EN12_13340	COG3852	Histidine kinase
EN12_13350	COG3300	MHYT domain
EN12_13350	COG5001	Diguanylate cyclase
EN12_13355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EN12_13390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EN12_13395	COG1404	Belongs to the peptidase S8 family
EN12_13400	COG4206	TonB-dependent receptor
EN12_13405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN12_13420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_13425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN12_13430	COG2177	Part of the ABC transporter FtsEX involved in
EN12_13435	COG2884	Cell division ATP-binding protein ftsE
EN12_13440	COG0552	protein localization to endoplasmic reticulum
EN12_13445	COG0742	ribosomal rna small subunit methyltransferase
EN12_13480	COG0783	Belongs to the Dps family
EN12_13485	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN12_13490	COG1280	lysine exporter protein (LysE YggA)
EN12_13495	COG2267	carboxylic ester hydrolase activity
EN12_13500	COG0561	phosphatase activity
EN12_13515	COG2199	diguanylate cyclase activity
EN12_13515	COG2200	EAL domain
EN12_13515	COG3287	FIST C domain
EN12_13520	COG1011	Hydrolase
EN12_13525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EN12_13535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EN12_13540	COG0019	diaminopimelate decarboxylase activity
EN12_13550	COG1965	Belongs to the frataxin family
EN12_13555	COG3072	Adenylate cyclase
EN12_13565	COG0181	hydroxymethylbilane synthase activity
EN12_13570	COG1587	Uroporphyrinogen-III synthase
EN12_13575	COG2959	enzyme of heme biosynthesis
EN12_13580	COG3071	HemY protein
EN12_13585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EN12_13595	COG3078	GTPase activator activity
EN12_13610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EN12_13615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_13615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_13630	COG0084	hydrolase, TatD family'
EN12_13635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN12_13645	COG0840	transmembrane signaling receptor activity
EN12_13650	COG1580	Controls the rotational direction of flagella during chemotaxis
EN12_13655	COG3161	chorismate lyase activity
EN12_13660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EN12_13665	COG2937	Belongs to the GPAT DAPAT family
EN12_13670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EN12_13680	COG0534	Mate efflux family protein
EN12_13685	COG1858	cytochrome C peroxidase
EN12_13690	COG0805	protein transport
EN12_13695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN12_13700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN12_13705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EN12_13715	COG2226	methyltransferase
EN12_13720	COG1322	Protein conserved in bacteria
EN12_13730	COG2081	HI0933 family
EN12_13740	COG1528	Iron-storage protein
EN12_13745	COG0589	response to stress
EN12_13750	COG0697	spore germination
EN12_13760	COG0742	ribosomal rna small subunit methyltransferase
EN12_13765	COG5001	Diguanylate cyclase
EN12_13765	COG5002	protein histidine kinase activity
EN12_13770	COG1522	sequence-specific DNA binding
EN12_13790	COG0006	proline dipeptidase activity
EN12_13790	COG0006	proline dipeptidase activity
EN12_13795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN12_13800	COG2022	thiamine diphosphate biosynthetic process
EN12_13805	COG2104	thiamine diphosphate biosynthetic process
EN12_13810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EN12_13820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EN12_13825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EN12_13865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EN12_13875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EN12_13880	COG0408	coproporphyrinogen oxidase activity
EN12_13885	COG0009	L-threonylcarbamoyladenylate synthase
EN12_13890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EN12_13895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EN12_13900	COG0551	DNA topoisomerase type I activity
EN12_13905	COG2922	Belongs to the Smg family
EN12_13910	COG0758	DNA mediated transformation
EN12_13915	COG1652	LysM domain
EN12_13920	COG0242	peptide deformylase activity
EN12_13925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EN12_13930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN12_13930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EN12_13935	COG0569	domain protein
EN12_13940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN12_13950	COG1272	protein, Hemolysin III
EN12_13955	COG4326	sporulation control protein
EN12_13965	COG3084	Protein conserved in bacteria
EN12_13975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EN12_13980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN12_13985	COG0204	Acyl-transferase
EN12_13990	COG0606	chelatase, subunit chli
EN12_14005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN12_14010	COG0129	dihydroxy-acid dehydratase activity
EN12_14020	COG0604	alcohol dehydrogenase
EN12_14030	COG0425	Belongs to the sulfur carrier protein TusA family
EN12_14040	COG2119	membrane
EN12_14045	COG0752	glycyl-tRNA synthetase alpha subunit
EN12_14050	COG0751	glycine-tRNA ligase activity
EN12_14055	COG3977	Valine--pyruvate aminotransferase
EN12_14060	COG0071	Belongs to the small heat shock protein (HSP20) family
EN12_14075	COG0187	DNA topoisomerase II activity
EN12_14080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EN12_14085	COG0592	DNA-directed DNA polymerase activity
EN12_14090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EN12_14125	COG0217	transcriptional regulatory protein
EN12_14130	COG2084	Dehydrogenase
EN12_14145	COG2909	trisaccharide binding
EN12_14150	COG0058	SHG alpha-glucan phosphorylase activity
EN12_14155	COG1640	4-alpha-glucanotransferase
EN12_14160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EN12_14170	COG3501	Rhs element vgr protein
EN12_14205	COG0471	metal ion transport
EN12_14210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EN12_14255	COG0671	phosphoesterase, PA-phosphatase related
EN12_14260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EN12_14270	COG1999	signal sequence binding
EN12_14285	COG0786	glutamate:sodium symporter activity
EN12_14305	COG1566	PFAM secretion protein HlyD family protein
EN12_14315	COG3706	GGDEF domain
EN12_14330	COG0813	purine-nucleoside phosphorylase activity
EN12_14335	COG3272	Protein of unknown function (DUF1722)
EN12_14345	COG0415	Belongs to the DNA photolyase family
EN12_14350	COG1388	LysM domain
EN12_14350	COG1376	ErfK ybiS ycfS ynhG family protein
EN12_14360	COG0513	Belongs to the DEAD box helicase family
EN12_14365	COG1770	oligopeptidase
EN12_14395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EN12_14400	COG0573	inorganic phosphate transmembrane transporter activity
EN12_14405	COG0581	inorganic phosphate transmembrane transporter activity
EN12_14410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EN12_14430	COG0659	secondary active sulfate transmembrane transporter activity
EN12_14440	COG0739	heme binding
EN12_14445	COG3300	MHYT domain
EN12_14445	COG5001	Diguanylate cyclase
EN12_14450	COG0583	DNA-binding transcription factor activity
EN12_14455	COG2814	Major facilitator Superfamily
EN12_14480	COG1301	dicarboxylic acid transport
EN12_14490	COG1342	Belongs to the UPF0251 family
EN12_14525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EN12_14530	COG0673	inositol 2-dehydrogenase activity
EN12_14540	COG2771	luxR family
EN12_14540	COG2200	EAL domain
EN12_14545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EN12_14555	COG0564	pseudouridine synthase activity
EN12_14645	COG3501	Rhs element vgr protein
EN12_14660	COG1869	D-ribose catabolic process
EN12_14665	COG1129	ABC transporter
EN12_14670	COG1172	Belongs to the binding-protein-dependent transport system permease family
EN12_14675	COG1879	ABC-type sugar transport system periplasmic component
EN12_14680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN12_14685	COG1609	Transcriptional regulator
EN12_14695	COG3201	nicotinamide mononucleotide transporter
EN12_14700	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EN12_14710	COG0584	glycerophosphoryl diester phosphodiesterase
EN12_14715	COG2271	Major facilitator Superfamily
EN12_14755	COG0579	oxidoreductase
EN12_14765	COG0242	peptide deformylase activity
EN12_14775	COG1320	monovalent cation:proton antiporter activity
EN12_14780	COG2212	antiporter activity
EN12_14800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EN12_14800	COG2111	Na H antiporter
EN12_14810	COG0589	response to stress
EN12_14815	COG0814	amino acid
EN12_14820	COG3033	Beta-eliminating lyase
EN12_14825	COG3530	Putative quorum-sensing-regulated virulence factor
EN12_14840	COG5001	Diguanylate cyclase
EN12_14840	COG5002	protein histidine kinase activity
EN12_14845	COG1278	Cold shock
EN12_14860	COG2304	oxidoreductase activity
EN12_14880	COG0714	Associated with various cellular activities
EN12_14885	COG0840	transmembrane signaling receptor activity
EN12_14900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN12_14905	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN12_14915	COG3604	Transcriptional regulator
EN12_14920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EN12_14920	COG1017	nitric oxide dioxygenase activity
EN12_14925	COG1278	Cold shock
EN12_14930	COG3036	rescue of stalled ribosome
EN12_14960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EN12_14960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EN12_14965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EN12_14975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EN12_14985	COG0516	GMP reductase activity
EN12_15010	COG1943	Transposase
EN12_15015	COG0513	Belongs to the DEAD box helicase family
EN12_15020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EN12_15025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EN12_15030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EN12_15035	COG0784	Response regulator, receiver
EN12_15035	COG3437	response regulator, receiver
EN12_15040	COG4191	Histidine kinase
EN12_15040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN12_15050	COG1757	Na H antiporter
EN12_15055	COG2814	Major facilitator Superfamily
EN12_15065	COG3706	GGDEF domain
EN12_15070	COG3240	lipase activity
EN12_15080	COG0840	transmembrane signaling receptor activity
EN12_15085	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EN12_15090	COG5380	lipid catabolic process
EN12_15095	COG3291	Pkd domain containing protein
EN12_15095	COG4412	M6 family metalloprotease domain protein
EN12_15115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN12_15120	COG4605	iron ion homeostasis
EN12_15125	COG4604	ABC transporter, ATP-binding protein
EN12_15145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EN12_15165	COG0745	RESPONSE REGULATOR receiver
EN12_15180	COG3623	hexulose-6-phosphate isomerase
EN12_15185	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EN12_15190	COG0561	phosphatase activity
EN12_15220	COG3038	cytochrome b561
EN12_15225	COG0366	Alpha amylase catalytic
EN12_15245	COG0745	RESPONSE REGULATOR receiver
EN12_15250	COG5002	protein histidine kinase activity
EN12_15275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EN12_15290	COG2814	Major facilitator Superfamily
EN12_15305	COG1686	Belongs to the peptidase S11 family
EN12_15325	COG1943	Transposase
EN12_15330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EN12_15330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EN12_15335	COG0509	glycine decarboxylation via glycine cleavage system
EN12_15340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EN12_15350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EN12_15360	COG3039	Transposase
EN12_15385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EN12_15395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EN12_15400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EN12_15435	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_15475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EN12_15500	COG0494	nUDIX hydrolase
EN12_15505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN12_15510	COG3040	lipid binding
EN12_15535	COG3041	Addiction module toxin RelE StbE family
EN12_15620	COG0346	lactoylglutathione lyase activity
EN12_15635	COG3040	lipid binding
EN12_15665	COG3040	lipid binding
EN12_15680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EN12_15685	COG1280	lysine exporter protein (LysE YggA)
EN12_15885	COG3549	Plasmid maintenance system killer
EN12_15890	COG3093	addiction module antidote protein HigA
EN12_15905	COG1619	proteins homologs of microcin C7 resistance protein MccF
EN12_15910	COG1619	proteins homologs of microcin C7 resistance protein MccF
EN12_15930	COG3040	lipid binding
EN12_15995	COG4977	sequence-specific DNA binding
EN12_16040	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EN12_16045	COG2944	sequence-specific DNA binding
EN12_16060	COG3039	Transposase
EN12_16080	COG0346	lactoylglutathione lyase activity
EN12_16165	COG1943	Transposase
EN12_16225	COG0346	lactoylglutathione lyase activity
EN12_16250	COG1328	CTP reductase activity
EN12_16255	COG0602	queuosine metabolic process
EN12_16265	COG4067	protein conserved in archaea
EN12_16265	COG0189	ligase activity
EN12_16275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_16275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_16275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EN12_16280	COG1105	Belongs to the carbohydrate kinase PfkB family
EN12_16285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_16285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_16290	COG1609	Transcriptional regulator
EN12_16295	COG0420	3'-5' exonuclease activity
EN12_16300	COG0419	ATPase involved in DNA repair
EN12_16305	COG2205	protein histidine kinase activity
EN12_16305	COG0784	Response regulator, receiver
EN12_16310	COG0156	8-amino-7-oxononanoate synthase activity
EN12_16320	COG0038	chloride channel
EN12_16325	COG0523	cobalamin synthesis protein
EN12_16335	COG3158	transport of potassium into the cell
EN12_16340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EN12_16340	COG0674	pyruvate-flavodoxin oxidoreductase activity
EN12_16340	COG1013	pyruvate-flavodoxin oxidoreductase activity
EN12_16340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EN12_16345	COG2205	protein histidine kinase activity
EN12_16350	COG0745	RESPONSE REGULATOR receiver
EN12_16355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN12_16360	COG0586	Pfam SNARE associated Golgi protein
EN12_16370	COG2200	EAL domain
EN12_16380	COG3038	cytochrome b561
EN12_16390	COG2116	formate transmembrane transporter activity
EN12_16395	COG0583	DNA-binding transcription factor activity
EN12_16405	COG3593	DNA synthesis involved in DNA repair
EN12_16410	COG0737	Belongs to the 5'-nucleotidase family
EN12_16425	COG2824	Alkylphosphonate utilization operon protein PhnA
EN12_16480	COG3706	GGDEF domain
EN12_16495	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EN12_16500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EN12_16510	COG0745	RESPONSE REGULATOR receiver
EN12_16535	COG0023	Translation Initiation Factor
EN12_16545	COG1181	Belongs to the D-alanine--D-alanine ligase family
EN12_16555	COG0045	succinate-CoA ligase (ADP-forming) activity
EN12_16555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN12_16555	COG1042	CoA-binding domain protein
EN12_16560	COG0583	DNA-binding transcription factor activity
EN12_16565	COG1629	transport
EN12_16565	COG4771	TonB-dependent receptor
EN12_16580	COG2050	protein possibly involved in aromatic compounds catabolism
EN12_16600	COG0625	glutathione transferase activity
EN12_16615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EN12_16620	COG4172	Belongs to the ABC transporter superfamily
EN12_16625	COG4239	(ABC) transporter, permease
EN12_16630	COG4174	ABC transporter (Permease)
EN12_16635	COG4166	transmembrane transport
EN12_16680	COG3842	ATPase activity
EN12_16690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EN12_16700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EN12_16705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN12_16710	COG1011	Hydrolase
EN12_16720	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EN12_16725	COG1970	mechanosensitive ion channel activity
EN12_16730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EN12_16735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_16735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_16740	COG0302	gtp cyclohydrolase
EN12_16750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EN12_16760	COG2897	thiosulfate sulfurtransferase activity
EN12_16765	COG2390	Transcriptional regulator
EN12_16775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EN12_16780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EN12_16805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN12_16830	COG0583	DNA-binding transcription factor activity
EN12_16835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EN12_16865	COG0640	Transcriptional regulator
EN12_16875	COG0446	pyridine nucleotide-disulphide oxidoreductase
EN12_16920	COG1263	PTS System
EN12_16920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_16930	COG1621	beta-fructofuranosidase activity
EN12_16935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN12_16940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EN12_16950	COG2885	chlorophyll binding
EN12_16955	COG0545	Peptidyl-prolyl cis-trans isomerase
EN12_16960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EN12_16965	COG0840	transmembrane signaling receptor activity
EN12_16970	COG3069	C4-dicarboxylate transmembrane transporter activity
EN12_16975	COG1760	l-serine dehydratase
EN12_16995	COG1609	Transcriptional regulator
EN12_17000	COG2197	response regulator
EN12_17005	COG3850	Histidine kinase
EN12_17010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EN12_17020	COG0243	molybdopterin cofactor binding
EN12_17040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EN12_17045	COG2197	response regulator
EN12_17050	COG3851	Histidine kinase
EN12_17055	COG2271	Major facilitator Superfamily
EN12_17060	COG1840	ABC-type Fe3 transport system, periplasmic component
EN12_17070	COG3842	ATPase activity
EN12_17075	COG3243	poly(R)-hydroxyalkanoic acid synthase
EN12_17085	COG0183	Belongs to the thiolase family
EN12_17095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN12_17100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN12_17115	COG3706	GGDEF domain
EN12_17120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EN12_17130	COG1979	alcohol dehydrogenase
EN12_17145	COG4191	Histidine kinase
EN12_17150	COG1840	ABC-type Fe3 transport system, periplasmic component
EN12_17155	COG2271	Major facilitator Superfamily
EN12_17160	COG0469	pyruvate kinase activity
EN12_17165	COG0784	Response regulator, receiver
EN12_17165	COG2198	Histidine kinase
EN12_17165	COG2205	protein histidine kinase activity
EN12_17170	COG1879	ABC-type sugar transport system periplasmic component
EN12_17175	COG1803	Methylglyoxal synthase
EN12_17180	COG1335	isochorismatase
EN12_17185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EN12_17200	COG0210	DNA helicase
EN12_17205	COG1289	transmembrane transporter activity
EN12_17235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EN12_17240	COG4149	molybdate abc transporter
EN12_17245	COG0725	ABC transporter, periplasmic molybdate-binding protein
EN12_17250	COG1492	cobalamin metabolic process
EN12_17295	COG5002	protein histidine kinase activity
EN12_17295	COG0784	Response regulator, receiver
EN12_17300	COG1879	ABC-type sugar transport system periplasmic component
EN12_17310	COG2827	Endonuclease containing a URI domain
EN12_17340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EN12_17350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EN12_17355	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EN12_17360	COG0247	lactate metabolic process
EN12_17365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EN12_17370	COG3118	belongs to the thioredoxin family
EN12_17400	COG0583	DNA-binding transcription factor activity
EN12_17405	COG4160	amino acid transport
EN12_17410	COG4215	(ABC) transporter
EN12_17415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN12_17420	COG1126	abc transporter atp-binding protein
EN12_17430	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EN12_17440	COG0494	nUDIX hydrolase
EN12_17445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EN12_17455	COG1309	transcriptional regulator
EN12_17460	COG0513	Belongs to the DEAD box helicase family
EN12_17465	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EN12_17475	COG0814	amino acid
EN12_17480	COG0840	transmembrane signaling receptor activity
EN12_17485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EN12_17490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EN12_17500	COG1984	allophanate hydrolase subunit 2
EN12_17515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EN12_17520	COG4181	ATPase activity
EN12_17530	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EN12_17535	COG1716	ATPase activity
EN12_17535	COG5001	Diguanylate cyclase
EN12_17550	COG0484	heat shock protein binding
EN12_17595	COG0546	phosphoglycolate phosphatase activity
EN12_17610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN12_17615	COG1368	sulfuric ester hydrolase activity
EN12_17625	COG0513	Belongs to the DEAD box helicase family
EN12_17630	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EN12_17640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EN12_17650	COG3046	protein related to deoxyribodipyrimidine photolyase
EN12_17655	COG3397	chitin binding
EN12_17660	COG3227	Zinc metalloprotease (Elastase)
EN12_17670	COG0010	Belongs to the arginase family
EN12_17675	COG1166	arginine decarboxylase activity
EN12_17685	COG2239	Acts as a magnesium transporter
EN12_17690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EN12_17695	COG0459	protein refolding
EN12_17705	COG0527	aspartate kinase activity
EN12_17710	COG0662	Cupin 2, conserved barrel domain protein
EN12_17715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EN12_17720	COG0456	acetyltransferase
EN12_17725	COG2154	pterin-4-alpha-carbinolamine dehydratase
EN12_17730	COG3186	Phenylalanine-4-hydroxylase
EN12_17735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EN12_17750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN12_17755	COG0583	DNA-binding transcription factor activity
EN12_17770	COG2171	N-acyltransferase activity
EN12_17775	COG1253	flavin adenine dinucleotide binding
EN12_17780	COG1765	OsmC-like protein
EN12_17805	COG0531	amino acid
EN12_17810	COG3706	GGDEF domain
EN12_17820	COG3279	Response regulator of the LytR AlgR family
EN12_17825	COG3275	phosphorelay sensor kinase activity
EN12_17840	COG0577	efflux transmembrane transporter activity
EN12_17840	COG1136	(ABC) transporter
EN12_17845	COG1136	(ABC) transporter
EN12_17860	COG4989	oxidoreductase activity
EN12_17865	COG0366	Alpha amylase catalytic
EN12_17880	COG2067	long-chain fatty acid transport protein
EN12_17885	COG2267	carboxylic ester hydrolase activity
EN12_17895	COG3227	Zinc metalloprotease (Elastase)
EN12_17900	COG3047	cAMP biosynthetic process
EN12_17910	COG1686	Belongs to the peptidase S11 family
EN12_17915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EN12_17920	COG1271	oxidase subunit
EN12_17925	COG1294	oxidase, subunit
EN12_17935	COG3048	D-serine ammonia-lyase activity
EN12_17940	COG0583	DNA-binding transcription factor activity
EN12_17980	COG1063	alcohol dehydrogenase
EN12_17995	COG0693	protein deglycase activity
EN12_18010	COG0346	lactoylglutathione lyase activity
EN12_18030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EN12_18035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EN12_18040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EN12_18045	COG0363	glucosamine-6-phosphate deaminase activity
EN12_18050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EN12_18075	COG1929	Belongs to the glycerate kinase type-1 family
EN12_18080	COG2610	gluconate transmembrane transporter activity
EN12_18085	COG3835	regulator
EN12_18095	COG0748	coenzyme F420 binding
EN12_18100	COG3721	Heme iron utilization protein
EN12_18110	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EN12_18115	COG0811	peptide transport
EN12_18120	COG0848	biopolymer transport protein
EN12_18125	COG4558	Periplasmic binding protein
EN12_18130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN12_18135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EN12_18170	COG3217	Mosc domain protein beta barrel domain protein
EN12_18170	COG3217	Mosc domain protein beta barrel domain protein
EN12_18170	COG0633	Ferredoxin
EN12_18170	COG0633	Ferredoxin
EN12_18175	COG0418	dihydroorotase activity
EN12_18185	COG3152	Membrane
EN12_18195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN12_18200	COG2354	Protein conserved in bacteria
EN12_18205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EN12_18210	COG1278	Cold shock
EN12_18235	COG3706	GGDEF domain
EN12_18240	COG1349	DNA-binding transcription factor activity
EN12_18255	COG3833	ABC-type maltose transport systems, permease component
EN12_18260	COG1175	transmembrane transport
EN12_18270	COG3842	ATPase activity
EN12_18275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN12_18290	COG0393	Putative heavy-metal-binding
EN12_18295	COG2197	response regulator
EN12_18300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN12_18305	COG0835	chemotaxis
EN12_18305	COG0784	Response regulator, receiver
EN12_18310	COG1846	Transcriptional regulator
EN12_18315	COG3706	GGDEF domain
EN12_18350	COG0583	DNA-binding transcription factor activity
EN12_18355	COG5001	Diguanylate cyclase
EN12_18365	COG1741	Belongs to the pirin family
EN12_18370	COG3123	guanosine phosphorylase activity
EN12_18380	COG2211	Major facilitator Superfamily
EN12_18390	COG0840	transmembrane signaling receptor activity
EN12_18395	COG1067	ATP-dependent peptidase activity
EN12_18405	COG4172	Belongs to the ABC transporter superfamily
EN12_18410	COG1943	Transposase
EN12_18435	COG0583	DNA-binding transcription factor activity
EN12_18440	COG1620	l-lactate permease
EN12_18445	COG1304	FMN binding
EN12_18455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EN12_18470	COG0840	transmembrane signaling receptor activity
EN12_18480	COG0513	Belongs to the DEAD box helicase family
EN12_18485	COG0583	DNA-binding transcription factor activity
EN12_18495	COG1902	pentaerythritol trinitrate reductase activity
EN12_18505	COG1132	(ABC) transporter
EN12_18515	COG1902	pentaerythritol trinitrate reductase activity
EN12_18525	COG1280	lysine exporter protein (LysE YggA)
EN12_18530	COG2207	Transcriptional regulator
EN12_18550	COG1846	Transcriptional regulator
EN12_18555	COG1764	response to oxidative stress
EN12_18565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN12_18570	COG0697	spore germination
EN12_18580	COG0700	Nucleoside recognition
EN12_18585	COG3366	ferrous iron transmembrane transporter activity
EN12_18590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EN12_18600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EN12_18605	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EN12_18610	COG2259	Doxx family
EN12_18635	COG0363	glucosamine-6-phosphate deaminase activity
EN12_18650	COG4580	involved in the transport of maltose and maltodextrins
EN12_18665	COG0840	transmembrane signaling receptor activity
EN12_18680	COG0840	transmembrane signaling receptor activity
EN12_18690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN12_18695	COG1126	abc transporter atp-binding protein
EN12_18705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN12_18710	COG4597	amino acid ABC transporter
EN12_18715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN12_18725	COG0739	heme binding
EN12_18735	COG2213	PTS system mannitol-specific
EN12_18735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_18740	COG0246	Mannitol dehydrogenase
EN12_18745	COG3722	fumarate hydratase activity
EN12_18750	COG0673	inositol 2-dehydrogenase activity
EN12_18780	COG2910	NAD(P)H-binding
EN12_18790	COG0840	transmembrane signaling receptor activity
EN12_18795	COG4221	oxidoreductase activity
EN12_18805	COG1901	pseudouridine methyltransferase
EN12_18810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EN12_18820	COG0531	amino acid
EN12_18825	COG1982	Orn Lys Arg decarboxylase major
EN12_18850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EN12_18875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EN12_18885	COG0259	pyridoxamine-phosphate oxidase activity
EN12_18915	COG0745	RESPONSE REGULATOR receiver
EN12_18935	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EN12_18940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN12_18945	COG0840	transmembrane signaling receptor activity
EN12_18950	COG0835	chemotaxis
EN12_18955	COG0835	chemotaxis
EN12_18960	COG2198	Histidine kinase
EN12_18960	COG0643	Histidine kinase
EN12_18985	COG0601	transmembrane transport
EN12_18990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN12_19000	COG2194	sulfuric ester hydrolase activity
EN12_19005	COG0642	Histidine kinase
EN12_19010	COG0745	RESPONSE REGULATOR receiver
EN12_19040	COG1444	tRNA N-acetyltransferase activity
EN12_19045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN12_19060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EN12_19155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_19170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_19230	COG2925	Exonuclease
EN12_19290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EN12_19295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_19295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_19335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EN12_19345	COG0210	DNA helicase
EN12_19360	COG2200	EAL domain
EN12_19380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EN12_19385	COG0316	Belongs to the HesB IscA family
EN12_19405	COG0305	Participates in initiation and elongation during chromosome replication
EN12_19410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EN12_19420	COG0750	zinc metalloprotease
EN12_19440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EN12_19450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EN12_19460	COG0514	ATP-dependent DNA helicase (RecQ)
EN12_19495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_19555	COG2974	May be involved in recombination
EN12_19590	COG0497	DNA recombination
EN12_19620	COG1078	dGTPase activity
EN12_19630	COG0653	protein targeting
EN12_19695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EN12_19780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EN12_19810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EN12_19895	COG0210	DNA helicase
EN12_19910	COG0675	Transposase, IS605 OrfB family
EN12_20010	COG4584	PFAM Integrase catalytic
EN12_20015	COG1484	DNA-dependent DNA replication
EN12_20200	COG3706	GGDEF domain
EN12_20215	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN12_20240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EN12_20255	COG2310	stress, protein
EN12_20270	COG1358	cellular component organization or biogenesis
EN12_20305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN12_20310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN12_20340	COG3038	cytochrome b561
EN12_20380	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EN12_20420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EN12_20425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EN12_20445	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EN12_20470	COG1435	thymidine kinase activity
EN12_20490	COG0822	iron-sulfur transferase activity
EN12_20500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EN12_20515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN12_20565	COG0776	regulation of translation
EN12_20610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EN12_20870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EN12_20885	COG1570	exodeoxyribonuclease VII activity
EN12_20890	COG2304	oxidoreductase activity
EN12_20965	COG0776	regulation of translation
EN12_20970	COG0602	queuosine metabolic process
EN12_21000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EN12_21065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EN12_21105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_21105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_21240	COG0675	Transposase, IS605 OrfB family
EN12_21265	COG0105	UTP biosynthetic process
EN12_21310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EN12_21315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EN12_21325	COG2194	sulfuric ester hydrolase activity
EN12_21330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EN12_21405	COG1358	cellular component organization or biogenesis
EN12_21415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EN12_21450	COG2137	regulation of response to DNA damage stimulus
EN12_21540	COG3341	Caulimovirus viroplasmin
EN12_21540	COG0328	RNA-DNA hybrid ribonuclease activity
EN12_21630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN12_21735	COG0629	single-stranded DNA binding
EN12_21830	COG0628	permease
EN12_21850	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EN12_21895	COG1160	GTP binding
EN12_22115	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EN12_22135	COG4584	PFAM Integrase catalytic
EN12_22140	COG1484	DNA-dependent DNA replication
EN12_22150	COG1192	Involved in chromosome partitioning
EN12_22155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN12_22160	COG0776	regulation of translation
EN12_22195	COG0675	Transposase, IS605 OrfB family
EN12_22220	COG1253	flavin adenine dinucleotide binding
EN12_22310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EN12_22330	COG1475	DNA binding
EN12_22480	COG0194	GDP metabolic process
EN12_22555	COG0671	phosphoesterase, PA-phosphatase related
EN12_22720	COG1328	CTP reductase activity
EN12_22995	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EN12_23165	COG4682	membrane
EN12_23380	COG1203	CRISPR-associated helicase, Cas3
EN12_23420	COG0675	Transposase, IS605 OrfB family
EN12_23500	COG0629	single-stranded DNA binding
EN12_23540	COG2916	Histone family protein nucleoid-structuring protein H-NS
EN12_23700	COG0494	nUDIX hydrolase
EN12_23745	COG0675	Transposase, IS605 OrfB family
EN12_23755	COG0675	Transposase, IS605 OrfB family
EN12_23825	COG3093	addiction module antidote protein HigA
EN12_23845	COG1199	ATP-dependent helicase activity
EN12_23905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN12_23955	COG2137	regulation of response to DNA damage stimulus
EN12_24030	COG0675	Transposase, IS605 OrfB family
EN12_24085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_24165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EN12_24415	COG0678	peroxiredoxin activity
EN12_24415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins