locus-tag	class	description
V060002_00001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V060002_00029	COG4974	Belongs to the 'phage' integrase family
V060002_00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
V060002_00031	COG0706	membrane insertase activity
V060002_00032	COG0594	ribonuclease P activity
V060002_00033	COG0230	Belongs to the bacterial ribosomal protein bL34 family
V060002_00034	COG1126	abc transporter atp-binding protein
V060002_00037	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
V060002_00038	COG0592	DNA-directed DNA polymerase activity
V060002_00039	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
V060002_00040	COG0187	DNA topoisomerase II activity
V060002_00043	COG0071	Belongs to the small heat shock protein (HSP20) family
V060002_00044	COG3977	Valine--pyruvate aminotransferase
V060002_00045	COG0751	glycine-tRNA ligase activity
V060002_00046	COG0752	glycyl-tRNA synthetase alpha subunit
V060002_00047	COG2119	membrane
V060002_00049	COG0425	Belongs to the sulfur carrier protein TusA family
V060002_00051	COG0604	alcohol dehydrogenase
V060002_00053	COG0129	dihydroxy-acid dehydratase activity
V060002_00054	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V060002_00057	COG0606	chelatase, subunit chli
V060002_00058	COG0204	Acyl-transferase
V060002_00059	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V060002_00060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
V060002_00062	COG3084	Protein conserved in bacteria
V060002_00063	COG4326	sporulation control protein
V060002_00064	COG1272	protein, Hemolysin III
V060002_00066	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V060002_00067	COG0569	domain protein
V060002_00068	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V060002_00068	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
V060002_00069	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
V060002_00070	COG0242	peptide deformylase activity
V060002_00071	COG1652	LysM domain
V060002_00072	COG0758	DNA mediated transformation
V060002_00073	COG2922	Belongs to the Smg family
V060002_00074	COG0551	DNA topoisomerase type I activity
V060002_00075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
V060002_00076	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
V060002_00077	COG0009	L-threonylcarbamoyladenylate synthase
V060002_00078	COG0408	coproporphyrinogen oxidase activity
V060002_00079	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
V060002_00081	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
V060002_00088	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
V060002_00089	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
V060002_00091	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V060002_00092	COG2104	thiamine diphosphate biosynthetic process
V060002_00093	COG2022	thiamine diphosphate biosynthetic process
V060002_00094	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V060002_00095	COG0006	proline dipeptidase activity
V060002_00095	COG0006	proline dipeptidase activity
V060002_00099	COG1522	sequence-specific DNA binding
V060002_00100	COG5002	protein histidine kinase activity
V060002_00100	COG5001	Diguanylate cyclase
V060002_00101	COG0742	ribosomal rna small subunit methyltransferase
V060002_00103	COG0697	spore germination
V060002_00104	COG0589	response to stress
V060002_00105	COG1528	Iron-storage protein
V060002_00107	COG2081	HI0933 family
V060002_00109	COG1322	Protein conserved in bacteria
V060002_00110	COG2226	methyltransferase
V060002_00112	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
V060002_00113	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V060002_00114	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V060002_00115	COG0805	protein transport
V060002_00116	COG1858	cytochrome C peroxidase
V060002_00117	COG0534	Mate efflux family protein
V060002_00119	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
V060002_00120	COG2937	Belongs to the GPAT DAPAT family
V060002_00121	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
V060002_00122	COG3161	chorismate lyase activity
V060002_00123	COG1580	Controls the rotational direction of flagella during chemotaxis
V060002_00124	COG0840	transmembrane signaling receptor activity
V060002_00126	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V060002_00127	COG0084	hydrolase, TatD family'
V060002_00130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V060002_00130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V060002_00131	COG0218	Necessary for normal cell division and for the maintenance of normal septation
V060002_00134	COG3078	GTPase activator activity
V060002_00136	COG0635	Involved in the biosynthesis of porphyrin-containing compound
V060002_00137	COG3071	HemY protein
V060002_00138	COG2959	enzyme of heme biosynthesis
V060002_00139	COG1587	Uroporphyrinogen-III synthase
V060002_00140	COG0181	hydroxymethylbilane synthase activity
V060002_00141	COG3072	Adenylate cyclase
V060002_00142	COG1965	Belongs to the frataxin family
V060002_00143	COG0019	diaminopimelate decarboxylase activity
V060002_00144	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
V060002_00146	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
V060002_00147	COG1011	Hydrolase
V060002_00148	COG2200	EAL domain
V060002_00148	COG2199	diguanylate cyclase activity
V060002_00148	COG3287	FIST C domain
V060002_00151	COG0561	phosphatase activity
V060002_00152	COG2267	carboxylic ester hydrolase activity
V060002_00153	COG1280	lysine exporter protein (LysE YggA)
V060002_00154	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V060002_00155	COG0783	Belongs to the Dps family
V060002_00160	COG0742	ribosomal rna small subunit methyltransferase
V060002_00161	COG0552	protein localization to endoplasmic reticulum
V060002_00162	COG2884	Cell division ATP-binding protein ftsE
V060002_00163	COG2177	Part of the ABC transporter FtsEX involved in
V060002_00164	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V060002_00165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_00168	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V060002_00169	COG4206	TonB-dependent receptor
V060002_00170	COG1404	Belongs to the peptidase S8 family
V060002_00171	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
V060002_00185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
V060002_00186	COG3300	MHYT domain
V060002_00186	COG5001	Diguanylate cyclase
V060002_00188	COG3852	Histidine kinase
V060002_00190	COG0174	glutamine synthetase
V060002_00195	COG1490	D-aminoacyl-tRNA deacylase activity
V060002_00196	COG0456	acetyltransferase
V060002_00198	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
V060002_00199	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
V060002_00200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
V060002_00201	COG3031	protein transport across the cell outer membrane
V060002_00203	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_00204	COG1459	type II secretion system
V060002_00205	COG2165	general secretion pathway protein
V060002_00206	COG2165	general secretion pathway protein
V060002_00207	COG2165	general secretion pathway protein
V060002_00208	COG4795	General secretion pathway protein
V060002_00209	COG3156	type II secretion system protein K
V060002_00210	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V060002_00211	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V060002_00213	COG1218	3'(2'),5'-bisphosphate nucleotidase
V060002_00214	COG0494	nUDIX hydrolase
V060002_00215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
V060002_00215	COG0316	Belongs to the HesB IscA family
V060002_00216	COG1040	competence protein
V060002_00217	COG0596	Alpha beta hydrolase
V060002_00219	COG2183	response to ionizing radiation
V060002_00220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V060002_00221	COG0745	RESPONSE REGULATOR receiver
V060002_00223	COG2233	PERMEase
V060002_00224	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
V060002_00225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V060002_00226	COG1758	RNA polymerase activity
V060002_00227	COG0194	GDP metabolic process
V060002_00228	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
V060002_00229	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V060002_00231	COG3263	regulation of cellular component size
V060002_00233	COG4232	protein-disulfide reductase activity
V060002_00236	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V060002_00237	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V060002_00238	COG1027	Aspartate ammonia-lyase
V060002_00239	COG3706	GGDEF domain
V060002_00240	COG3030	protein affecting phage T7 exclusion by the F plasmid
V060002_00241	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
V060002_00243	COG2205	protein histidine kinase activity
V060002_00244	COG0745	RESPONSE REGULATOR receiver
V060002_00246	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
V060002_00247	COG0205	6-phosphofructokinase activity
V060002_00248	COG1494	fructose-1,6-bisphosphatase
V060002_00249	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
V060002_00250	COG0460	homoserine dehydrogenase
V060002_00250	COG0527	aspartate kinase activity
V060002_00251	COG0626	cystathionine gamma-synthase activity
V060002_00252	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
V060002_00253	COG0281	malic enzyme
V060002_00254	COG0254	rRNA binding
V060002_00255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
V060002_00256	COG1609	Transcriptional regulator
V060002_00257	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
V060002_00258	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
V060002_00259	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
V060002_00260	COG1575	Belongs to the MenA family. Type 1 subfamily
V060002_00261	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V060002_00263	COG0149	triose-phosphate isomerase activity
V060002_00268	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
V060002_00269	COG0459	protein refolding
V060002_00271	COG1509	lysine 2,3-aminomutase activity
V060002_00272	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
V060002_00273	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
V060002_00274	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
V060002_00275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
V060002_00276	COG1053	succinate dehydrogenase
V060002_00277	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
V060002_00278	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V060002_00279	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
V060002_00280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
V060002_00281	COG1045	serine acetyltransferase
V060002_00283	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
V060002_00284	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
V060002_00285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
V060002_00286	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V060002_00287	COG0137	argininosuccinate synthase activity
V060002_00288	COG0165	Argininosuccinate lyase
V060002_00290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_00291	COG0678	peroxiredoxin activity
V060002_00291	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
V060002_00293	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
V060002_00299	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
V060002_00300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
V060002_00302	COG0338	D12 class N6 adenine-specific DNA methyltransferase
V060002_00303	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
V060002_00304	COG0546	phosphoglycolate phosphatase activity
V060002_00305	COG0180	Tryptophanyl-tRNA synthetase
V060002_00308	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V060002_00310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
V060002_00312	COG1012	belongs to the aldehyde dehydrogenase family
V060002_00314	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
V060002_00315	COG3954	Phosphoribulokinase
V060002_00317	COG0429	hydrolase of the alpha beta-hydrolase fold
V060002_00319	COG0488	(ABC) transporter
V060002_00320	COG2249	NAD(P)H dehydrogenase (quinone) activity
V060002_00323	COG1047	Peptidyl-prolyl cis-trans
V060002_00325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
V060002_00326	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
V060002_00327	COG3083	sulfuric ester hydrolase activity
V060002_00328	COG0557	exoribonuclease II activity
V060002_00329	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
V060002_00330	COG0051	transcription antitermination factor activity, RNA binding
V060002_00331	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
V060002_00332	COG0088	Forms part of the polypeptide exit tunnel
V060002_00333	COG0089	rRNA binding
V060002_00334	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
V060002_00335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
V060002_00336	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
V060002_00337	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
V060002_00338	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
V060002_00339	COG0255	Belongs to the universal ribosomal protein uL29 family
V060002_00340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
V060002_00341	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
V060002_00342	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
V060002_00343	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
V060002_00344	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
V060002_00345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
V060002_00346	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
V060002_00347	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
V060002_00348	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
V060002_00349	COG1841	ribosomal large subunit assembly
V060002_00350	COG0200	Binds to the 23S rRNA
V060002_00351	COG0201	protein transport
V060002_00353	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
V060002_00354	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
V060002_00355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
V060002_00356	COG0202	RNA polymerase activity
V060002_00357	COG0203	ribosomal protein L17
V060002_00359	COG0545	Peptidyl-prolyl cis-trans isomerase
V060002_00360	COG3266	domain, Protein
V060002_00360	COG3061	Opacity-associated protein A
V060002_00361	COG0697	spore germination
V060002_00362	COG2153	protein acetylation
V060002_00363	COG0513	Belongs to the DEAD box helicase family
V060002_00365	COG0737	Belongs to the 5'-nucleotidase family
V060002_00366	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
V060002_00366	COG1648	precorrin-2 dehydrogenase activity
V060002_00367	COG0175	sulfate reduction
V060002_00368	COG2895	sulfate adenylyltransferase (ATP) activity
V060002_00369	COG0529	Catalyzes the synthesis of activated sulfate
V060002_00373	COG1136	(ABC) transporter
V060002_00376	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
V060002_00377	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_00378	COG0729	surface antigen
V060002_00380	COG2105	PFAM AIG2 family protein
V060002_00381	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
V060002_00382	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
V060002_00383	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V060002_00384	COG0163	prenyltransferase activity
V060002_00385	COG4143	(ABC) transporter
V060002_00386	COG1178	ABC-type Fe3 transport system permease component
V060002_00387	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
V060002_00388	COG3028	Belongs to the UPF0307 family
V060002_00389	COG0312	modulator of DNA gyrase
V060002_00390	COG2239	Acts as a magnesium transporter
V060002_00391	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_00392	COG1660	Displays ATPase and GTPase activities
V060002_00393	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_00394	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
V060002_00396	COG1137	ATPase activity
V060002_00397	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
V060002_00400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
V060002_00400	COG0517	IMP dehydrogenase activity
V060002_00402	COG1127	ABC transporter
V060002_00403	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
V060002_00404	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V060002_00405	COG2854	intermembrane phospholipid transfer
V060002_00407	COG5007	Belongs to the BolA IbaG family
V060002_00408	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
V060002_00409	COG0204	Acyl-transferase
V060002_00410	COG0251	oxidation-reduction process
V060002_00411	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
V060002_00412	COG0540	Belongs to the ATCase OTCase family
V060002_00413	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
V060002_00414	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
V060002_00415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
V060002_00416	COG0564	pseudouridine synthase activity
V060002_00417	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V060002_00418	COG0525	valine-tRNA ligase activity
V060002_00419	COG2927	DNA polymerase III (CHI subunit)
V060002_00420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V060002_00421	COG0795	lipopolysaccharide-transporting ATPase activity
V060002_00422	COG0795	lipopolysaccharide-transporting ATPase activity
V060002_00425	COG3437	response regulator, receiver
V060002_00434	COG0066	3-isopropylmalate dehydratase activity
V060002_00435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
V060002_00436	COG0473	3-isopropylmalate dehydrogenase activity
V060002_00437	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
V060002_00441	COG0583	DNA-binding transcription factor activity
V060002_00442	COG1022	Amp-dependent synthetase and ligase
V060002_00443	COG0028	Belongs to the TPP enzyme family
V060002_00444	COG0440	acetolactate synthase activity
V060002_00445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V060002_00446	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
V060002_00447	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
V060002_00448	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
V060002_00450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_00451	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_00453	COG0354	folic acid binding
V060002_00454	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
V060002_00456	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
V060002_00457	COG1595	DNA-templated transcription, initiation
V060002_00459	COG3026	antisigma factor binding
V060002_00460	COG3086	response to oxidative stress
V060002_00461	COG0481	GTPase activity
V060002_00462	COG0681	Belongs to the peptidase S26 family
V060002_00463	COG0571	ribonuclease III activity
V060002_00464	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
V060002_00465	COG1381	Involved in DNA repair and RecF pathway recombination
V060002_00466	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
V060002_00467	COG0736	holo-[acyl-carrier-protein] synthase activity
V060002_00470	COG5001	Diguanylate cyclase
V060002_00472	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V060002_00473	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V060002_00474	COG3956	TIGRFAM MazG family protein
V060002_00475	COG0504	CTP synthase activity
V060002_00476	COG0148	phosphopyruvate hydratase activity
V060002_00477	COG0617	tRNA 3'-terminal CCA addition
V060002_00478	COG3267	Type II secretory pathway component ExeA
V060002_00478	COG3409	Peptidoglycan-binding domain 1 protein
V060002_00480	COG4991	sh3 domain protein
V060002_00481	COG0306	phosphate transporter
V060002_00482	COG1392	Phosphate transport regulator
V060002_00483	COG3025	triphosphatase activity
V060002_00485	COG0840	transmembrane signaling receptor activity
V060002_00486	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V060002_00487	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V060002_00488	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V060002_00489	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V060002_00490	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V060002_00491	COG3956	TIGRFAM MazG family protein
V060002_00493	COG0504	CTP synthase activity
V060002_00494	COG0504	CTP synthase activity
V060002_00495	COG0148	phosphopyruvate hydratase activity
V060002_00496	COG0617	tRNA 3'-terminal CCA addition
V060002_00497	COG3267	Type II secretory pathway component ExeA
V060002_00497	COG3409	Peptidoglycan-binding domain 1 protein
V060002_00499	COG4991	sh3 domain protein
V060002_00500	COG0306	phosphate transporter
V060002_00501	COG1392	Phosphate transport regulator
V060002_00502	COG3025	triphosphatase activity
V060002_00504	COG0840	transmembrane signaling receptor activity
V060002_00505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V060002_00507	COG1538	Outer membrane efflux protein
V060002_00508	COG0494	nUDIX hydrolase
V060002_00509	COG3151	Protein conserved in bacteria
V060002_00511	COG3150	esterase
V060002_00512	COG0187	DNA topoisomerase II activity
V060002_00513	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
V060002_00514	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
V060002_00515	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
V060002_00516	COG0237	dephospho-CoA kinase activity
V060002_00518	COG1459	type II secretion system
V060002_00519	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_00523	COG0716	FMN binding
V060002_00524	COG4974	Belongs to the 'phage' integrase family
V060002_00525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V060002_00526	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
V060002_00527	COG0737	Belongs to the 5'-nucleotidase family
V060002_00528	COG2186	Transcriptional regulator
V060002_00529	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
V060002_00530	COG0508	dehydrogenase complex catalyzes the overall conversion of
V060002_00531	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_00532	COG0275	rRNA processing
V060002_00533	COG3116	cell division
V060002_00534	COG0768	penicillin binding
V060002_00535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
V060002_00536	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
V060002_00537	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
V060002_00538	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
V060002_00539	COG0772	Belongs to the SEDS family
V060002_00540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
V060002_00541	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V060002_00542	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
V060002_00543	COG0849	cell division
V060002_00544	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
V060002_00545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
V060002_00547	COG0653	protein targeting
V060002_00548	COG0494	nUDIX hydrolase
V060002_00549	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
V060002_00550	COG0505	Belongs to the CarA family
V060002_00551	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
V060002_00555	COG4172	Belongs to the ABC transporter superfamily
V060002_00557	COG0730	response to heat
V060002_00558	COG0583	DNA-binding transcription factor activity
V060002_00559	COG2860	membrane
V060002_00560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
V060002_00562	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
V060002_00564	COG0493	'glutamate synthase
V060002_00565	COG0067	glutamate synthase
V060002_00565	COG0069	glutamate synthase activity
V060002_00565	COG0070	glutamate synthase
V060002_00567	COG0069	glutamate synthase activity
V060002_00567	COG0067	glutamate synthase
V060002_00567	COG0070	glutamate synthase
V060002_00568	COG1242	4 iron, 4 sulfur cluster binding
V060002_00569	COG2203	Gaf domain
V060002_00569	COG3706	GGDEF domain
V060002_00569	COG4251	negative regulation of phosphorylation
V060002_00569	COG5001	Diguanylate cyclase
V060002_00570	COG2198	Histidine kinase
V060002_00570	COG5002	protein histidine kinase activity
V060002_00570	COG0784	Response regulator, receiver
V060002_00571	COG0745	RESPONSE REGULATOR receiver
V060002_00573	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V060002_00576	COG0083	homoserine kinase activity
V060002_00577	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
V060002_00578	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
V060002_00579	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
V060002_00580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
V060002_00583	COG1115	amino acid carrier protein
V060002_00586	COG0084	hydrolase, TatD family'
V060002_00587	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V060002_00588	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
V060002_00589	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
V060002_00590	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
V060002_00591	COG0813	purine-nucleoside phosphorylase activity
V060002_00593	COG0560	Phosphoserine phosphatase
V060002_00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
V060002_00596	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
V060002_00597	COG1022	Amp-dependent synthetase and ligase
V060002_00600	COG3250	beta-galactosidase activity
V060002_00601	COG1609	Transcriptional regulator
V060002_00602	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_00605	COG0569	domain protein
V060002_00605	COG0189	ligase activity
V060002_00607	COG0456	acetyltransferase
V060002_00609	COG2171	N-acyltransferase activity
V060002_00610	COG3141	response to X-ray
V060002_00613	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
V060002_00614	COG1074	ATP-dependent DNA helicase activity
V060002_00615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
V060002_00617	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V060002_00617	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
V060002_00619	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
V060002_00620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
V060002_00621	COG2166	iron-sulfur cluster assembly
V060002_00622	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V060002_00623	COG0693	protein deglycase activity
V060002_00624	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
V060002_00625	COG3248	Nucleoside-binding outer membrane protein
V060002_00627	COG1595	DNA-templated transcription, initiation
V060002_00629	COG2211	Major facilitator Superfamily
V060002_00630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V060002_00632	COG2813	Specifically methylates the guanine in position
V060002_00633	COG0271	Belongs to the BolA IbaG family
V060002_00634	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_00635	COG1805	sodium ion transport
V060002_00636	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_00637	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_00638	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_00639	COG2871	sodium ion transport
V060002_00640	COG1477	protein flavinylation
V060002_00642	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
V060002_00645	COG3706	GGDEF domain
V060002_00646	COG0733	neurotransmitter:sodium symporter activity
V060002_00648	COG0189	ligase activity
V060002_00649	COG0189	ligase activity
V060002_00649	COG4067	protein conserved in archaea
V060002_00650	COG2195	Cleaves the N-terminal amino acid of tripeptides
V060002_00651	COG2252	PERMEase
V060002_00652	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
V060002_00655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
V060002_00656	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
V060002_00657	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
V060002_00658	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V060002_00658	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V060002_00661	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
V060002_00662	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V060002_00663	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
V060002_00664	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
V060002_00666	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
V060002_00667	COG0024	Methionine aminopeptidase
V060002_00668	COG0052	Belongs to the universal ribosomal protein uS2 family
V060002_00669	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
V060002_00670	COG0528	UMP kinase activity
V060002_00671	COG0233	cytoplasmic translational termination
V060002_00672	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
V060002_00673	COG0575	Belongs to the CDS family
V060002_00674	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
V060002_00675	COG0750	zinc metalloprotease
V060002_00677	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
V060002_00678	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_00679	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V060002_00680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_00681	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_00682	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
V060002_00683	COG0587	DNA-directed DNA polymerase activity
V060002_00684	COG0825	malonyl-CoA metabolic process
V060002_00685	COG0037	tRNA processing
V060002_00687	COG3479	Phenolic acid decarboxylase
V060002_00688	COG0347	Belongs to the P(II) protein family
V060002_00690	COG1388	LysM domain
V060002_00690	COG0741	lytic transglycosylase activity
V060002_00691	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V060002_00692	COG2226	methyltransferase
V060002_00693	COG0328	RNA-DNA hybrid ribonuclease activity
V060002_00694	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
V060002_00696	COG1960	acyl-CoA dehydrogenase activity
V060002_00697	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V060002_00698	COG0121	glutamine amidotransferase
V060002_00699	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
V060002_00700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
V060002_00701	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
V060002_00703	COG3706	GGDEF domain
V060002_00704	COG1187	pseudouridine synthase activity
V060002_00705	COG2840	Smr protein MutS2
V060002_00708	COG3735	TraB family
V060002_00711	COG2217	Heavy metal translocating P-type atpase
V060002_00711	COG2608	mercury ion transmembrane transporter activity
V060002_00712	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V060002_00715	COG4774	siderophore transport
V060002_00715	COG1629	transport
V060002_00716	COG2375	cellular response to nickel ion
V060002_00717	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V060002_00717	COG3433	isochorismatase activity
V060002_00717	COG2226	methyltransferase
V060002_00724	COG0784	Response regulator, receiver
V060002_00724	COG0835	chemotaxis
V060002_00725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V060002_00726	COG1815	bacterial-type flagellum-dependent cell motility
V060002_00727	COG1558	bacterial-type flagellum-dependent cell motility
V060002_00728	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
V060002_00729	COG1749	Flagellar hook protein flgE
V060002_00730	COG4787	bacterial-type flagellum-dependent cell motility
V060002_00731	COG4786	Flagellar basal body rod
V060002_00732	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
V060002_00733	COG1706	bacterial-type flagellum-dependent cell motility
V060002_00734	COG3951	Flagellar rod assembly protein muramidase FlgJ
V060002_00734	COG1705	Flagellar rod assembly protein muramidase FlgJ
V060002_00737	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_00738	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_00755	COG0012	GTP binding
V060002_00756	COG0193	aminoacyl-tRNA hydrolase activity
V060002_00757	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
V060002_00758	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
V060002_00759	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
V060002_00760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
V060002_00761	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
V060002_00762	COG2890	protein-(glutamine-N5) methyltransferase activity
V060002_00763	COG3094	Invasion gene expression up-regulator, SirB
V060002_00764	COG2912	Transglutaminase-like superfamily
V060002_00765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
V060002_00766	COG0737	Belongs to the 5'-nucleotidase family
V060002_00767	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
V060002_00768	COG2233	PERMEase
V060002_00772	COG1393	Belongs to the ArsC family
V060002_00773	COG4783	chaperone-mediated protein folding
V060002_00776	COG0840	transmembrane signaling receptor activity
V060002_00777	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
V060002_00779	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
V060002_00780	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
V060002_00782	COG1876	peptidase activity
V060002_00783	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
V060002_00784	COG1393	Belongs to the ArsC family
V060002_00788	COG2837	iron assimilation
V060002_00789	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_00790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_00791	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_00792	COG1334	flagellar protein FlaG
V060002_00793	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
V060002_00795	COG1516	flagellar protein fliS
V060002_00796	COG2204	response regulator
V060002_00797	COG4191	Histidine kinase
V060002_00798	COG2204	response regulator
V060002_00799	COG1677	Flagellar hook-basal body complex protein FliE
V060002_00801	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
V060002_00802	COG1317	bacterial-type flagellum organization
V060002_00806	COG1580	Controls the rotational direction of flagella during chemotaxis
V060002_00811	COG1987	bacterial-type flagellum assembly
V060002_00812	COG1684	flagellar biosynthetic protein fliR
V060002_00815	COG2890	protein-(glutamine-N5) methyltransferase activity
V060002_00816	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
V060002_00817	COG2860	membrane
V060002_00818	COG3101	peptidyl-lysine hydroxylation
V060002_00820	COG0431	NADPH-dependent FMN reductase
V060002_00821	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
V060002_00821	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V060002_00822	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V060002_00823	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V060002_00824	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V060002_00825	COG0735	belongs to the Fur family
V060002_00827	COG0583	DNA-binding transcription factor activity
V060002_00829	COG1346	cytolysis
V060002_00832	COG0596	Alpha beta hydrolase
V060002_00833	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
V060002_00834	COG0033	Phosphoglucomutase
V060002_00836	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
V060002_00837	COG0372	Belongs to the citrate synthase family
V060002_00838	COG2009	succinate dehydrogenase
V060002_00839	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
V060002_00840	COG1053	succinate dehydrogenase
V060002_00842	COG0567	Dehydrogenase, E1 component
V060002_00843	COG0508	dehydrogenase complex catalyzes the overall conversion of
V060002_00844	COG0045	succinate-CoA ligase (ADP-forming) activity
V060002_00846	COG1108	ABC-type Mn2 Zn2 transport systems permease components
V060002_00847	COG1121	(ABC) transporter
V060002_00848	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
V060002_00849	COG4977	sequence-specific DNA binding
V060002_00850	COG1918	ferrous iron import across plasma membrane
V060002_00854	COG0018	arginyl-trna synthetase
V060002_00856	COG1025	Belongs to the peptidase M16 family
V060002_00857	COG2062	phosphohistidine phosphatase, SixA
V060002_00860	COG0455	bacterial-type flagellum organization
V060002_00863	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
V060002_00864	COG0643	Histidine kinase
V060002_00864	COG2198	Histidine kinase
V060002_00865	COG2201	protein-glutamate methylesterase activity
V060002_00866	COG1192	Involved in chromosome partitioning
V060002_00868	COG0835	chemotaxis
V060002_00870	COG4133	protoheme IX ABC transporter activity
V060002_00871	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V060002_00872	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V060002_00874	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
V060002_00875	COG1138	Cytochrome C-type biogenesis protein
V060002_00876	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
V060002_00877	COG3088	subunit of a heme lyase
V060002_00877	COG4235	cytochrome complex assembly
V060002_00879	COG2853	Lipoprotein
V060002_00883	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
V060002_00884	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V060002_00885	COG0123	including yeast histone deacetylase and acetoin utilization protein
V060002_00888	COG3083	sulfuric ester hydrolase activity
V060002_00890	COG3081	Nucleoid-associated protein
V060002_00892	COG1757	Na H antiporter
V060002_00893	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V060002_00894	COG2095	MarC family integral membrane protein
V060002_00895	COG1454	alcohol dehydrogenase
V060002_00895	COG1012	belongs to the aldehyde dehydrogenase family
V060002_00897	COG0659	secondary active sulfate transmembrane transporter activity
V060002_00898	COG1530	ribonuclease E activity
V060002_00899	COG0564	pseudouridine synthase activity
V060002_00900	COG0424	maF-like protein
V060002_00901	COG1399	metal-binding, possibly nucleic acid-binding protein
V060002_00902	COG0333	Belongs to the bacterial ribosomal protein bL32 family
V060002_00903	COG0416	fatty acid biosynthetic process
V060002_00904	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
V060002_00905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
V060002_00906	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_00907	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
V060002_00908	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V060002_00909	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V060002_00910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
V060002_00911	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
V060002_00913	COG0084	hydrolase, TatD family'
V060002_00914	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_00914	COG1263	PTS System
V060002_00916	COG0733	neurotransmitter:sodium symporter activity
V060002_00919	COG4667	esterase of the alpha-beta hydrolase superfamily
V060002_00921	COG1940	carbohydrate kinase activity
V060002_00922	COG0835	chemotaxis
V060002_00922	COG0784	Response regulator, receiver
V060002_00925	COG2226	methyltransferase
V060002_00927	COG0676	glucose-6-phosphate 1-epimerase activity
V060002_00928	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V060002_00929	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_00931	COG3139	Protein of unknown function (DUF1315)
V060002_00932	COG0252	asparaginase activity
V060002_00933	COG0616	signal peptide processing
V060002_00934	COG0446	pyridine nucleotide-disulphide oxidoreductase
V060002_00934	COG1902	pentaerythritol trinitrate reductase activity
V060002_00935	COG0788	formyltetrahydrofolate deformylase activity
V060002_00937	COG1199	ATP-dependent helicase activity
V060002_00938	COG1214	PFAM Peptidase M22, glycoprotease
V060002_00941	COG0596	Alpha beta hydrolase
V060002_00942	COG0318	PFAM AMP-dependent synthetase and ligase
V060002_00943	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
V060002_00947	COG0232	Belongs to the dGTPase family. Type 2 subfamily
V060002_00948	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
V060002_00949	COG0436	Aminotransferase
V060002_00950	COG1169	isochorismate synthase
V060002_00951	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
V060002_00952	COG0596	Alpha beta hydrolase
V060002_00954	COG1441	menaquinone biosynthetic process
V060002_00956	COG3135	benzoate transporter
V060002_00957	COG1396	sequence-specific DNA binding
V060002_00958	COG0840	transmembrane signaling receptor activity
V060002_00959	COG0477	Major facilitator Superfamily
V060002_00964	COG3015	lipoprotein NlpE involved in copper resistance
V060002_00965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
V060002_00966	COG2894	cell division
V060002_00967	COG0850	regulation of cytokinetic process
V060002_00968	COG3100	YcgL domain-containing protein
V060002_00969	COG2951	lytic endotransglycosylase activity
V060002_00971	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V060002_00972	COG3469	chitinase activity
V060002_00972	COG3325	Belongs to the glycosyl hydrolase 18 family
V060002_00973	COG3005	denitrification pathway
V060002_00974	COG0243	molybdopterin cofactor binding
V060002_00978	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_00980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
V060002_00987	COG4589	Belongs to the CDS family
V060002_00989	COG5001	Diguanylate cyclase
V060002_00989	COG3300	MHYT domain
V060002_00992	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
V060002_00993	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
V060002_00994	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
V060002_00995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
V060002_00997	COG4191	Histidine kinase
V060002_00998	COG0544	peptidyl-prolyl cis-trans isomerase activity
V060002_01000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
V060002_01001	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
V060002_01002	COG0776	regulation of translation
V060002_01003	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V060002_01004	COG1555	photosystem II stabilization
V060002_01005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
V060002_01006	COG0539	negative regulation of cytoplasmic translation
V060002_01007	COG0776	regulation of translation
V060002_01008	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
V060002_01009	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
V060002_01010	COG0284	orotidine-5'-phosphate decarboxylase activity
V060002_01013	COG0583	DNA-binding transcription factor activity
V060002_01015	COG0686	Belongs to the AlaDH PNT family
V060002_01017	COG1674	ftsk spoiiie
V060002_01018	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
V060002_01019	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V060002_01020	COG2186	Transcriptional regulator
V060002_01023	COG0537	adenosine 5'-monophosphoramidase activity
V060002_01029	COG1252	NADH dehydrogenase
V060002_01033	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
V060002_01035	COG4591	ABC-type transport system involved in lipoprotein release permease component
V060002_01036	COG1136	(ABC) transporter
V060002_01037	COG4591	ABC-type transport system involved in lipoprotein release permease component
V060002_01039	COG2333	competence protein COMEC
V060002_01039	COG0658	competence protein
V060002_01040	COG1132	(ABC) transporter
V060002_01041	COG1663	tetraacyldisaccharide 4'-kinase activity
V060002_01043	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
V060002_01044	COG2719	SpoVR family
V060002_01045	COG2718	Belongs to the UPF0229 family
V060002_01046	COG2766	serine protein kinase
V060002_01047	COG3013	Belongs to the UPF0304 family
V060002_01049	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
V060002_01050	COG0840	transmembrane signaling receptor activity
V060002_01052	COG1882	Formate acetyltransferase
V060002_01057	COG4215	(ABC) transporter
V060002_01058	COG4160	amino acid transport
V060002_01059	COG0708	Exodeoxyribonuclease III
V060002_01060	COG0840	transmembrane signaling receptor activity
V060002_01062	COG3923	Primosomal replication protein n
V060002_01063	COG0730	response to heat
V060002_01064	COG1199	ATP-dependent helicase activity
V060002_01065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V060002_01066	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V060002_01068	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V060002_01069	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_01070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V060002_01071	COG0215	cysteine-tRNA ligase activity
V060002_01072	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
V060002_01073	COG0632	four-way junction helicase activity
V060002_01074	COG2255	four-way junction helicase activity
V060002_01076	COG1271	oxidase subunit
V060002_01077	COG1294	oxidase, subunit
V060002_01078	COG4890	Cyd operon protein YbgT
V060002_01079	COG0824	Thioesterase
V060002_01080	COG0811	peptide transport
V060002_01083	COG0823	Involved in the tonB-independent uptake of proteins
V060002_01084	COG2885	chlorophyll binding
V060002_01086	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
V060002_01088	COG5002	protein histidine kinase activity
V060002_01088	COG0784	Response regulator, receiver
V060002_01090	COG1482	cell wall glycoprotein biosynthetic process
V060002_01091	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_01091	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_01091	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_01092	COG2207	Transcriptional regulator
V060002_01094	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_01095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_01096	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_01098	COG1012	belongs to the aldehyde dehydrogenase family
V060002_01099	COG3284	Transcriptional regulator
V060002_01100	COG4628	conserved protein (DUF2132)
V060002_01102	COG0415	Belongs to the DNA photolyase family
V060002_01117	COG0488	(ABC) transporter
V060002_01125	COG3941	tape measure
V060002_01130	COG0484	heat shock protein binding
V060002_01132	COG5001	Diguanylate cyclase
V060002_01132	COG1716	ATPase activity
V060002_01133	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V060002_01135	COG4181	ATPase activity
V060002_01136	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
V060002_01139	COG1984	allophanate hydrolase subunit 2
V060002_01141	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
V060002_01142	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
V060002_01143	COG0840	transmembrane signaling receptor activity
V060002_01144	COG0814	amino acid
V060002_01146	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
V060002_01147	COG0513	Belongs to the DEAD box helicase family
V060002_01148	COG1309	transcriptional regulator
V060002_01150	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
V060002_01151	COG0494	nUDIX hydrolase
V060002_01153	COG2425	protein containing a von Willebrand factor type A (vWA) domain
V060002_01155	COG1126	abc transporter atp-binding protein
V060002_01156	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_01157	COG4215	(ABC) transporter
V060002_01158	COG4160	amino acid transport
V060002_01159	COG0583	DNA-binding transcription factor activity
V060002_01165	COG3118	belongs to the thioredoxin family
V060002_01166	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
V060002_01167	COG0247	lactate metabolic process
V060002_01168	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
V060002_01169	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
V060002_01170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
V060002_01171	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
V060002_01177	COG2827	Endonuclease containing a URI domain
V060002_01179	COG1879	ABC-type sugar transport system periplasmic component
V060002_01180	COG5002	protein histidine kinase activity
V060002_01180	COG0784	Response regulator, receiver
V060002_01188	COG1492	cobalamin metabolic process
V060002_01189	COG0725	ABC transporter, periplasmic molybdate-binding protein
V060002_01190	COG4149	molybdate abc transporter
V060002_01191	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
V060002_01197	COG1289	transmembrane transporter activity
V060002_01198	COG0210	DNA helicase
V060002_01201	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
V060002_01202	COG1335	isochorismatase
V060002_01203	COG1803	Methylglyoxal synthase
V060002_01204	COG1879	ABC-type sugar transport system periplasmic component
V060002_01205	COG2205	protein histidine kinase activity
V060002_01205	COG2198	Histidine kinase
V060002_01205	COG0784	Response regulator, receiver
V060002_01206	COG0469	pyruvate kinase activity
V060002_01207	COG2271	Major facilitator Superfamily
V060002_01209	COG1840	ABC-type Fe3 transport system, periplasmic component
V060002_01210	COG4191	Histidine kinase
V060002_01213	COG1979	alcohol dehydrogenase
V060002_01215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V060002_01216	COG3706	GGDEF domain
V060002_01219	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_01220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_01222	COG0183	Belongs to the thiolase family
V060002_01224	COG3243	poly(R)-hydroxyalkanoic acid synthase
V060002_01225	COG3842	ATPase activity
V060002_01227	COG1840	ABC-type Fe3 transport system, periplasmic component
V060002_01228	COG2271	Major facilitator Superfamily
V060002_01229	COG3851	Histidine kinase
V060002_01230	COG2197	response regulator
V060002_01231	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V060002_01235	COG0243	molybdopterin cofactor binding
V060002_01237	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V060002_01238	COG3850	Histidine kinase
V060002_01239	COG2197	response regulator
V060002_01240	COG1609	Transcriptional regulator
V060002_01245	COG1760	l-serine dehydratase
V060002_01246	COG3069	C4-dicarboxylate transmembrane transporter activity
V060002_01247	COG0840	transmembrane signaling receptor activity
V060002_01248	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V060002_01249	COG0545	Peptidyl-prolyl cis-trans isomerase
V060002_01250	COG2885	chlorophyll binding
V060002_01252	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
V060002_01253	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_01254	COG1621	beta-fructofuranosidase activity
V060002_01256	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_01256	COG1263	PTS System
V060002_01265	COG0446	pyridine nucleotide-disulphide oxidoreductase
V060002_01267	COG0640	Transcriptional regulator
V060002_01273	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
V060002_01274	COG0583	DNA-binding transcription factor activity
V060002_01279	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V060002_01284	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
V060002_01285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
V060002_01286	COG2390	Transcriptional regulator
V060002_01287	COG2897	thiosulfate sulfurtransferase activity
V060002_01289	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V060002_01291	COG0302	gtp cyclohydrolase
V060002_01292	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_01292	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_01293	COG2759	Belongs to the formate--tetrahydrofolate ligase family
V060002_01294	COG1970	mechanosensitive ion channel activity
V060002_01295	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
V060002_01297	COG1011	Hydrolase
V060002_01298	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V060002_01299	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V060002_01301	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
V060002_01303	COG3842	ATPase activity
V060002_01312	COG4166	transmembrane transport
V060002_01313	COG4174	ABC transporter (Permease)
V060002_01314	COG4239	(ABC) transporter, permease
V060002_01315	COG4172	Belongs to the ABC transporter superfamily
V060002_01316	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
V060002_01319	COG0625	glutathione transferase activity
V060002_01323	COG2050	protein possibly involved in aromatic compounds catabolism
V060002_01326	COG4771	TonB-dependent receptor
V060002_01326	COG1629	transport
V060002_01327	COG0583	DNA-binding transcription factor activity
V060002_01328	COG0045	succinate-CoA ligase (ADP-forming) activity
V060002_01328	COG1042	CoA-binding domain protein
V060002_01328	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_01330	COG1181	Belongs to the D-alanine--D-alanine ligase family
V060002_01332	COG0023	Translation Initiation Factor
V060002_01335	COG4128	Pfam Zonular occludens toxin
V060002_01345	COG4128	Pfam Zonular occludens toxin
V060002_01356	COG0745	RESPONSE REGULATOR receiver
V060002_01358	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
V060002_01359	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
V060002_01362	COG3706	GGDEF domain
V060002_01372	COG2824	Alkylphosphonate utilization operon protein PhnA
V060002_01376	COG0737	Belongs to the 5'-nucleotidase family
V060002_01377	COG3593	DNA synthesis involved in DNA repair
V060002_01379	COG0583	DNA-binding transcription factor activity
V060002_01380	COG2116	formate transmembrane transporter activity
V060002_01382	COG3038	cytochrome b561
V060002_01384	COG2200	EAL domain
V060002_01386	COG0586	Pfam SNARE associated Golgi protein
V060002_01387	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V060002_01388	COG0745	RESPONSE REGULATOR receiver
V060002_01389	COG2205	protein histidine kinase activity
V060002_01390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
V060002_01390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V060002_01390	COG0674	pyruvate-flavodoxin oxidoreductase activity
V060002_01390	COG1013	pyruvate-flavodoxin oxidoreductase activity
V060002_01391	COG3158	transport of potassium into the cell
V060002_01393	COG0523	cobalamin synthesis protein
V060002_01394	COG0038	chloride channel
V060002_01396	COG0156	8-amino-7-oxononanoate synthase activity
V060002_01397	COG2205	protein histidine kinase activity
V060002_01397	COG0784	Response regulator, receiver
V060002_01398	COG0419	ATPase involved in DNA repair
V060002_01399	COG0420	3'-5' exonuclease activity
V060002_01400	COG1609	Transcriptional regulator
V060002_01401	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_01401	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_01402	COG1105	Belongs to the carbohydrate kinase PfkB family
V060002_01403	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_01403	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_01403	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
V060002_01404	COG4067	protein conserved in archaea
V060002_01404	COG0189	ligase activity
V060002_01406	COG0602	queuosine metabolic process
V060002_01407	COG1328	CTP reductase activity
V060002_01412	COG0346	lactoylglutathione lyase activity
V060002_01422	COG1943	Transposase
V060002_01438	COG0346	lactoylglutathione lyase activity
V060002_01441	COG0110	maltose O-acetyltransferase activity
V060002_01442	COG3039	Transposase
V060002_01445	COG2944	sequence-specific DNA binding
V060002_01446	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
V060002_01457	COG4977	sequence-specific DNA binding
V060002_01458	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
V060002_01459	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
V060002_01470	COG3040	lipid binding
V060002_01474	COG1619	proteins homologs of microcin C7 resistance protein MccF
V060002_01475	COG3093	addiction module antidote protein HigA
V060002_01476	COG3549	Plasmid maintenance system killer
V060002_01510	COG1619	proteins homologs of microcin C7 resistance protein MccF
V060002_01519	COG3041	Addiction module toxin RelE StbE family
V060002_01523	COG3040	lipid binding
V060002_01524	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_01526	COG0494	nUDIX hydrolase
V060002_01531	COG0232	Belongs to the dGTPase family. Type 2 subfamily
V060002_01534	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_01540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
V060002_01541	COG0291	Belongs to the bacterial ribosomal protein bL35 family
V060002_01543	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
V060002_01548	COG3039	Transposase
V060002_01550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
V060002_01552	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
V060002_01553	COG0509	glycine decarboxylation via glycine cleavage system
V060002_01554	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V060002_01554	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V060002_01555	COG1943	Transposase
V060002_01559	COG1686	Belongs to the peptidase S11 family
V060002_01562	COG2814	Major facilitator Superfamily
V060002_01565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
V060002_01570	COG5002	protein histidine kinase activity
V060002_01571	COG0745	RESPONSE REGULATOR receiver
V060002_01576	COG0366	Alpha amylase catalytic
V060002_01577	COG3038	cytochrome b561
V060002_01583	COG0561	phosphatase activity
V060002_01584	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
V060002_01585	COG3623	hexulose-6-phosphate isomerase
V060002_01587	COG0745	RESPONSE REGULATOR receiver
V060002_01591	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
V060002_01595	COG4604	ABC transporter, ATP-binding protein
V060002_01596	COG4605	iron ion homeostasis
V060002_01597	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_01601	COG4412	M6 family metalloprotease domain protein
V060002_01601	COG3291	Pkd domain containing protein
V060002_01602	COG5380	lipid catabolic process
V060002_01603	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
V060002_01604	COG0840	transmembrane signaling receptor activity
V060002_01606	COG3240	lipase activity
V060002_01607	COG3706	GGDEF domain
V060002_01608	COG2814	Major facilitator Superfamily
V060002_01609	COG1757	Na H antiporter
V060002_01611	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_01611	COG4191	Histidine kinase
V060002_01612	COG3437	response regulator, receiver
V060002_01612	COG0784	Response regulator, receiver
V060002_01614	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
V060002_01615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
V060002_01616	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V060002_01617	COG0513	Belongs to the DEAD box helicase family
V060002_01618	COG1943	Transposase
V060002_01623	COG0516	GMP reductase activity
V060002_01625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V060002_01627	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V060002_01628	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
V060002_01628	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
V060002_01633	COG3036	rescue of stalled ribosome
V060002_01634	COG1278	Cold shock
V060002_01635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V060002_01635	COG1017	nitric oxide dioxygenase activity
V060002_01636	COG3604	Transcriptional regulator
V060002_01638	COG2195	Cleaves the N-terminal amino acid of tripeptides
V060002_01639	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V060002_01642	COG0840	transmembrane signaling receptor activity
V060002_01643	COG0714	Associated with various cellular activities
V060002_01647	COG2304	oxidoreductase activity
V060002_01650	COG1278	Cold shock
V060002_01651	COG5001	Diguanylate cyclase
V060002_01651	COG5002	protein histidine kinase activity
V060002_01653	COG3530	Putative quorum-sensing-regulated virulence factor
V060002_01655	COG3033	Beta-eliminating lyase
V060002_01656	COG0814	amino acid
V060002_01657	COG0589	response to stress
V060002_01659	COG2111	Na H antiporter
V060002_01659	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
V060002_01663	COG2212	antiporter activity
V060002_01664	COG1320	monovalent cation:proton antiporter activity
V060002_01666	COG0242	peptide deformylase activity
V060002_01668	COG0579	oxidoreductase
V060002_01675	COG2271	Major facilitator Superfamily
V060002_01676	COG0584	glycerophosphoryl diester phosphodiesterase
V060002_01678	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
V060002_01680	COG1609	Transcriptional regulator
V060002_01681	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_01682	COG1879	ABC-type sugar transport system periplasmic component
V060002_01683	COG1172	Belongs to the binding-protein-dependent transport system permease family
V060002_01684	COG1129	ABC transporter
V060002_01685	COG1869	D-ribose catabolic process
V060002_01688	COG3501	Rhs element vgr protein
V060002_01706	COG0564	pseudouridine synthase activity
V060002_01708	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V060002_01709	COG2200	EAL domain
V060002_01709	COG2771	luxR family
V060002_01711	COG0673	inositol 2-dehydrogenase activity
V060002_01712	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
V060002_01718	COG1342	Belongs to the UPF0251 family
V060002_01720	COG1301	dicarboxylic acid transport
V060002_01725	COG2814	Major facilitator Superfamily
V060002_01726	COG0583	DNA-binding transcription factor activity
V060002_01728	COG3300	MHYT domain
V060002_01728	COG5001	Diguanylate cyclase
V060002_01729	COG0739	heme binding
V060002_01731	COG0659	secondary active sulfate transmembrane transporter activity
V060002_01735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
V060002_01736	COG0581	inorganic phosphate transmembrane transporter activity
V060002_01737	COG0573	inorganic phosphate transmembrane transporter activity
V060002_01738	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
V060002_01744	COG1770	oligopeptidase
V060002_01745	COG0513	Belongs to the DEAD box helicase family
V060002_01747	COG1376	ErfK ybiS ycfS ynhG family protein
V060002_01747	COG1388	LysM domain
V060002_01748	COG0415	Belongs to the DNA photolyase family
V060002_01750	COG3272	Protein of unknown function (DUF1722)
V060002_01751	COG0813	purine-nucleoside phosphorylase activity
V060002_01754	COG3706	GGDEF domain
V060002_01756	COG1566	PFAM secretion protein HlyD family protein
V060002_01760	COG0786	glutamate:sodium symporter activity
V060002_01763	COG1999	signal sequence binding
V060002_01765	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
V060002_01766	COG0671	phosphoesterase, PA-phosphatase related
V060002_01775	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V060002_01776	COG0471	metal ion transport
V060002_01783	COG3501	Rhs element vgr protein
V060002_01785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
V060002_01786	COG1640	4-alpha-glucanotransferase
V060002_01787	COG0058	SHG alpha-glucan phosphorylase activity
V060002_01788	COG2909	trisaccharide binding
V060002_01791	COG2084	Dehydrogenase
V060002_01792	COG0217	transcriptional regulatory protein
V060002_01799	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V060002_01800	COG1444	tRNA N-acetyltransferase activity
V060002_01806	COG0745	RESPONSE REGULATOR receiver
V060002_01807	COG0642	Histidine kinase
V060002_01808	COG2194	sulfuric ester hydrolase activity
V060002_01810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_01811	COG0601	transmembrane transport
V060002_01815	COG0643	Histidine kinase
V060002_01815	COG2198	Histidine kinase
V060002_01816	COG0835	chemotaxis
V060002_01817	COG0835	chemotaxis
V060002_01818	COG0840	transmembrane signaling receptor activity
V060002_01819	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V060002_01820	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
V060002_01824	COG0745	RESPONSE REGULATOR receiver
V060002_01830	COG0259	pyridoxamine-phosphate oxidase activity
V060002_01832	COG1262	PFAM Formylglycine-generating sulfatase enzyme
V060002_01837	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V060002_01842	COG1982	Orn Lys Arg decarboxylase major
V060002_01843	COG0531	amino acid
V060002_01844	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
V060002_01845	COG1901	pseudouridine methyltransferase
V060002_01847	COG4221	oxidoreductase activity
V060002_01848	COG0840	transmembrane signaling receptor activity
V060002_01850	COG2910	NAD(P)H-binding
V060002_01856	COG0673	inositol 2-dehydrogenase activity
V060002_01857	COG3722	fumarate hydratase activity
V060002_01858	COG0246	Mannitol dehydrogenase
V060002_01859	COG2213	PTS system mannitol-specific
V060002_01859	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_01861	COG0739	heme binding
V060002_01862	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
V060002_01863	COG4597	amino acid ABC transporter
V060002_01864	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_01866	COG1126	abc transporter atp-binding protein
V060002_01867	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V060002_01869	COG0840	transmembrane signaling receptor activity
V060002_01872	COG0840	transmembrane signaling receptor activity
V060002_01875	COG4580	involved in the transport of maltose and maltodextrins
V060002_01878	COG0363	glucosamine-6-phosphate deaminase activity
V060002_01883	COG2259	Doxx family
V060002_01884	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
V060002_01885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
V060002_01887	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
V060002_01888	COG3366	ferrous iron transmembrane transporter activity
V060002_01889	COG0700	Nucleoside recognition
V060002_01891	COG0697	spore germination
V060002_01892	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V060002_01893	COG1764	response to oxidative stress
V060002_01894	COG1846	Transcriptional regulator
V060002_01898	COG2207	Transcriptional regulator
V060002_01899	COG1280	lysine exporter protein (LysE YggA)
V060002_01901	COG1902	pentaerythritol trinitrate reductase activity
V060002_01903	COG1132	(ABC) transporter
V060002_01905	COG1902	pentaerythritol trinitrate reductase activity
V060002_01907	COG0583	DNA-binding transcription factor activity
V060002_01908	COG0513	Belongs to the DEAD box helicase family
V060002_01910	COG0840	transmembrane signaling receptor activity
V060002_01912	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
V060002_01914	COG1304	FMN binding
V060002_01915	COG1620	l-lactate permease
V060002_01916	COG0583	DNA-binding transcription factor activity
V060002_01921	COG4172	Belongs to the ABC transporter superfamily
V060002_01923	COG1067	ATP-dependent peptidase activity
V060002_01924	COG0840	transmembrane signaling receptor activity
V060002_01926	COG2211	Major facilitator Superfamily
V060002_01928	COG3123	guanosine phosphorylase activity
V060002_01929	COG1741	Belongs to the pirin family
V060002_01931	COG5001	Diguanylate cyclase
V060002_01932	COG0583	DNA-binding transcription factor activity
V060002_01939	COG3706	GGDEF domain
V060002_01940	COG1846	Transcriptional regulator
V060002_01941	COG0835	chemotaxis
V060002_01941	COG0784	Response regulator, receiver
V060002_01942	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V060002_01943	COG2197	response regulator
V060002_01944	COG0393	Putative heavy-metal-binding
V060002_01947	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_01948	COG3842	ATPase activity
V060002_01950	COG1175	transmembrane transport
V060002_01951	COG3833	ABC-type maltose transport systems, permease component
V060002_01954	COG1349	DNA-binding transcription factor activity
V060002_01955	COG3706	GGDEF domain
V060002_01957	COG2207	Transcriptional regulator
V060002_01957	COG4753	response regulator
V060002_01960	COG1278	Cold shock
V060002_01962	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V060002_01963	COG2354	Protein conserved in bacteria
V060002_01964	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V060002_01966	COG3152	Membrane
V060002_01968	COG0418	dihydroorotase activity
V060002_01969	COG3217	Mosc domain protein beta barrel domain protein
V060002_01969	COG0633	Ferredoxin
V060002_01969	COG3217	Mosc domain protein beta barrel domain protein
V060002_01969	COG0633	Ferredoxin
V060002_01976	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
V060002_01977	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_01978	COG4558	Periplasmic binding protein
V060002_01979	COG0848	biopolymer transport protein
V060002_01980	COG0811	peptide transport
V060002_01981	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
V060002_01983	COG3721	Heme iron utilization protein
V060002_01984	COG0748	coenzyme F420 binding
V060002_01986	COG3835	regulator
V060002_01987	COG2610	gluconate transmembrane transporter activity
V060002_01988	COG1929	Belongs to the glycerate kinase type-1 family
V060002_01993	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
V060002_01994	COG0363	glucosamine-6-phosphate deaminase activity
V060002_01995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
V060002_01996	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V060002_01997	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
V060002_02001	COG0346	lactoylglutathione lyase activity
V060002_02004	COG0693	protein deglycase activity
V060002_02007	COG1063	alcohol dehydrogenase
V060002_02014	COG0583	DNA-binding transcription factor activity
V060002_02015	COG3048	D-serine ammonia-lyase activity
V060002_02018	COG1294	oxidase, subunit
V060002_02019	COG1271	oxidase subunit
V060002_02020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
V060002_02021	COG1686	Belongs to the peptidase S11 family
V060002_02023	COG3047	cAMP biosynthetic process
V060002_02024	COG3227	Zinc metalloprotease (Elastase)
V060002_02026	COG2267	carboxylic ester hydrolase activity
V060002_02027	COG2067	long-chain fatty acid transport protein
V060002_02028	COG0366	Alpha amylase catalytic
V060002_02029	COG4989	oxidoreductase activity
V060002_02031	COG1136	(ABC) transporter
V060002_02032	COG1136	(ABC) transporter
V060002_02032	COG0577	efflux transmembrane transporter activity
V060002_02035	COG3275	phosphorelay sensor kinase activity
V060002_02036	COG3279	Response regulator of the LytR AlgR family
V060002_02038	COG3706	GGDEF domain
V060002_02039	COG0531	amino acid
V060002_02044	COG1765	OsmC-like protein
V060002_02045	COG1253	flavin adenine dinucleotide binding
V060002_02046	COG2171	N-acyltransferase activity
V060002_02049	COG0583	DNA-binding transcription factor activity
V060002_02050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V060002_02053	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V060002_02054	COG3186	Phenylalanine-4-hydroxylase
V060002_02055	COG2154	pterin-4-alpha-carbinolamine dehydratase
V060002_02056	COG0456	acetyltransferase
V060002_02057	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
V060002_02058	COG0662	Cupin 2, conserved barrel domain protein
V060002_02059	COG0527	aspartate kinase activity
V060002_02061	COG0459	protein refolding
V060002_02062	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
V060002_02063	COG2239	Acts as a magnesium transporter
V060002_02065	COG1166	arginine decarboxylase activity
V060002_02066	COG0010	Belongs to the arginase family
V060002_02068	COG3227	Zinc metalloprotease (Elastase)
V060002_02069	COG3397	chitin binding
V060002_02070	COG3046	protein related to deoxyribodipyrimidine photolyase
V060002_02072	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
V060002_02074	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
V060002_02075	COG0513	Belongs to the DEAD box helicase family
V060002_02077	COG1368	sulfuric ester hydrolase activity
V060002_02078	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_02081	COG0546	phosphoglycolate phosphatase activity
V060002_02090	COG2003	Belongs to the UPF0758 family
V060002_02092	COG4409	exo-alpha-(2->6)-sialidase activity
V060002_02093	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V060002_02094	COG1940	carbohydrate kinase activity
V060002_02095	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
V060002_02096	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
V060002_02097	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
V060002_02098	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
V060002_02099	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
V060002_02100	COG1737	Transcriptional regulator
V060002_02101	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
V060002_02102	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
V060002_02106	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
V060002_02110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
V060002_02114	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
V060002_02115	COG0582	viral genome integration into host DNA
V060002_02116	COG0582	viral genome integration into host DNA
V060002_02119	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_02121	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V060002_02121	COG3008	intermembrane lipid transfer
V060002_02122	COG2995	paraquat-inducible protein a
V060002_02123	COG0668	transmembrane transport
V060002_02127	COG1309	transcriptional regulator
V060002_02128	COG1012	belongs to the aldehyde dehydrogenase family
V060002_02133	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V060002_02134	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
V060002_02135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
V060002_02136	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
V060002_02137	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
V060002_02139	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V060002_02140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V060002_02141	COG0297	glycogen (starch) synthase activity
V060002_02146	COG3070	regulator of competence-specific genes
V060002_02147	COG1609	Transcriptional regulator
V060002_02148	COG3381	protein complex oligomerization
V060002_02149	COG0745	RESPONSE REGULATOR receiver
V060002_02150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
V060002_02151	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V060002_02152	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
V060002_02153	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
V060002_02154	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
V060002_02157	COG1032	radical SAM domain protein
V060002_02159	COG0612	Peptidase, M16
V060002_02162	COG0583	DNA-binding transcription factor activity
V060002_02163	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
V060002_02165	COG2350	Protein conserved in bacteria
V060002_02166	COG1607	acyl-coa hydrolase
V060002_02167	COG2917	probably involved in intracellular septation
V060002_02169	COG1434	Gram-negative-bacterium-type cell wall biogenesis
V060002_02170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V060002_02172	COG2116	formate transmembrane transporter activity
V060002_02173	COG4459	periplasmic nitrate reductase
V060002_02174	COG3005	denitrification pathway
V060002_02175	COG0243	molybdopterin cofactor binding
V060002_02179	COG1227	inorganic diphosphatase activity
V060002_02182	COG4172	Belongs to the ABC transporter superfamily
V060002_02184	COG4171	peptide transport system, permease
V060002_02185	COG4168	peptide transport system, permease
V060002_02187	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
V060002_02188	COG1842	Phage shock protein A
V060002_02191	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_02194	COG2818	Glycosylase
V060002_02195	COG0626	cystathionine gamma-synthase activity
V060002_02197	COG0733	neurotransmitter:sodium symporter activity
V060002_02198	COG0564	pseudouridine synthase activity
V060002_02199	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
V060002_02200	COG4136	ATPase activity
V060002_02201	COG4135	transport system, permease component
V060002_02202	COG4134	Bacterial extracellular solute-binding protein
V060002_02204	COG3313	Fe-S protein
V060002_02206	COG0842	Transport permease protein
V060002_02207	COG1131	(ABC) transporter
V060002_02208	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_02209	COG0814	amino acid
V060002_02212	COG2239	Acts as a magnesium transporter
V060002_02216	COG4934	collagen metabolic process
V060002_02222	COG0840	transmembrane signaling receptor activity
V060002_02224	COG4251	negative regulation of phosphorylation
V060002_02224	COG3706	GGDEF domain
V060002_02224	COG2203	Gaf domain
V060002_02224	COG5001	Diguanylate cyclase
V060002_02225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
V060002_02229	COG1061	Type III restriction enzyme res subunit
V060002_02230	COG1187	pseudouridine synthase activity
V060002_02231	COG2814	Major facilitator Superfamily
V060002_02233	COG0702	epimerase
V060002_02234	COG0534	Mate efflux family protein
V060002_02235	COG4181	ATPase activity
V060002_02238	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V060002_02240	COG1748	Saccharopine dehydrogenase
V060002_02241	COG0019	diaminopimelate decarboxylase activity
V060002_02243	COG1538	Outer membrane efflux protein
V060002_02247	COG0583	DNA-binding transcription factor activity
V060002_02249	COG1451	nucleotide metabolic process
V060002_02250	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
V060002_02252	COG3063	Type IV pilus biogenesis stability protein PilW
V060002_02253	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
V060002_02257	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_02260	COG3290	protein histidine kinase activity
V060002_02261	COG4565	transcriptional regulatory protein
V060002_02263	COG0835	chemotaxis
V060002_02263	COG0784	Response regulator, receiver
V060002_02266	COG0745	RESPONSE REGULATOR receiver
V060002_02266	COG3706	GGDEF domain
V060002_02271	COG1085	galactose-1-phosphate uridylyltransferase
V060002_02272	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
V060002_02273	COG2017	converts alpha-aldose to the beta-anomer
V060002_02274	COG3706	GGDEF domain
V060002_02275	COG2199	diguanylate cyclase activity
V060002_02275	COG2200	EAL domain
V060002_02278	COG3527	Alpha-acetolactate decarboxylase
V060002_02279	COG3527	Alpha-acetolactate decarboxylase
V060002_02282	COG0753	catalase activity
V060002_02286	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
V060002_02288	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V060002_02296	COG1271	oxidase subunit
V060002_02297	COG1294	oxidase, subunit
V060002_02298	COG1136	(ABC) transporter
V060002_02298	COG4591	ABC-type transport system involved in lipoprotein release permease component
V060002_02299	COG0577	efflux transmembrane transporter activity
V060002_02299	COG1136	(ABC) transporter
V060002_02300	COG1136	(ABC) transporter
V060002_02300	COG0577	efflux transmembrane transporter activity
V060002_02304	COG0583	DNA-binding transcription factor activity
V060002_02305	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
V060002_02306	COG2723	6-phospho-beta-galactosidase activity
V060002_02307	COG1609	Transcriptional regulator
V060002_02308	COG0251	oxidation-reduction process
V060002_02309	COG2731	YhcH YjgK YiaL family protein
V060002_02310	COG0584	glycerophosphoryl diester phosphodiesterase
V060002_02311	COG1349	DNA-binding transcription factor activity
V060002_02312	COG3842	ATPase activity
V060002_02313	COG0395	ABC-type sugar transport system, permease component
V060002_02314	COG1175	transmembrane transport
V060002_02317	COG0811	peptide transport
V060002_02318	COG0811	peptide transport
V060002_02319	COG0848	biopolymer transport protein
V060002_02320	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
V060002_02322	COG1793	dna ligase
V060002_02324	COG0534	Mate efflux family protein
V060002_02328	COG0791	NLP P60 protein
V060002_02329	COG0840	transmembrane signaling receptor activity
V060002_02332	COG1940	carbohydrate kinase activity
V060002_02337	COG0746	molybdenum cofactor guanylyltransferase activity
V060002_02338	COG3842	ATPase activity
V060002_02339	COG4662	Binding-protein-dependent transport system inner membrane component
V060002_02341	COG2204	response regulator
V060002_02342	COG3852	Histidine kinase
V060002_02343	COG0488	(ABC) transporter
V060002_02344	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
V060002_02350	COG3383	formate dehydrogenase (NAD+) activity
V060002_02350	COG0243	molybdopterin cofactor binding
V060002_02351	COG0437	4 iron, 4 sulfur cluster binding
V060002_02354	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
V060002_02356	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V060002_02359	COG2996	Protein conserved in bacteria
V060002_02360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
V060002_02360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
V060002_02361	COG3008	intermembrane lipid transfer
V060002_02362	COG2995	paraquat-inducible protein a
V060002_02363	COG1132	(ABC) transporter
V060002_02364	COG1956	GAF domain-containing protein
V060002_02365	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
V060002_02368	COG0308	aminopeptidase N
V060002_02370	COG0167	dihydroorotate dehydrogenase activity
V060002_02373	COG0116	Belongs to the methyltransferase superfamily
V060002_02373	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V060002_02378	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V060002_02379	COG1067	ATP-dependent peptidase activity
V060002_02380	COG3120	sequence-specific DNA binding
V060002_02383	COG3064	Membrane
V060002_02383	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
V060002_02383	COG1073	alpha beta
V060002_02384	COG2994	toxin metabolic process
V060002_02389	COG2205	protein histidine kinase activity
V060002_02389	COG0784	Response regulator, receiver
V060002_02392	COG3278	Belongs to the heme-copper respiratory oxidase family
V060002_02395	COG2010	Cytochrome c
V060002_02397	COG2217	Heavy metal translocating P-type atpase
V060002_02400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
V060002_02401	COG0589	response to stress
V060002_02402	COG0037	tRNA processing
V060002_02406	COG3842	ATPase activity
V060002_02407	COG1176	ABC-type spermidine putrescine transport system, permease component I
V060002_02408	COG1177	transmembrane transport
V060002_02409	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V060002_02410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V060002_02413	COG1115	amino acid carrier protein
V060002_02414	COG1280	lysine exporter protein (LysE YggA)
V060002_02419	COG3501	Rhs element vgr protein
V060002_02421	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
V060002_02422	COG0840	transmembrane signaling receptor activity
V060002_02423	COG2814	Major facilitator Superfamily
V060002_02424	COG1566	PFAM secretion protein HlyD family protein
V060002_02425	COG1538	Outer membrane efflux protein
V060002_02427	COG0513	Belongs to the DEAD box helicase family
V060002_02429	COG0840	transmembrane signaling receptor activity
V060002_02430	COG3290	protein histidine kinase activity
V060002_02430	COG0840	transmembrane signaling receptor activity
V060002_02431	COG0835	chemotaxis
V060002_02432	COG2201	protein-glutamate methylesterase activity
V060002_02434	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V060002_02436	COG2198	Histidine kinase
V060002_02436	COG0643	Histidine kinase
V060002_02440	COG2076	Multidrug Resistance protein
V060002_02441	COG0415	Belongs to the DNA photolyase family
V060002_02442	COG0477	Major facilitator Superfamily
V060002_02443	COG0583	DNA-binding transcription factor activity
V060002_02444	COG0095	Lipoate-protein ligase
V060002_02445	COG0443	Heat shock 70 kDa protein
V060002_02447	COG1643	Atp-dependent helicase
V060002_02454	COG0443	Heat shock 70 kDa protein
V060002_02455	COG0443	Heat shock 70 kDa protein
V060002_02456	COG3706	GGDEF domain
V060002_02462	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
V060002_02463	COG0602	queuosine metabolic process
V060002_02465	COG0561	phosphatase activity
V060002_02467	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_02468	COG4597	amino acid ABC transporter
V060002_02469	COG0765	amino acid transport
V060002_02470	COG1126	abc transporter atp-binding protein
V060002_02471	COG0670	Belongs to the BI1 family
V060002_02472	COG2920	part of a sulfur-relay system
V060002_02473	COG1254	Belongs to the acylphosphatase family
V060002_02474	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V060002_02475	COG3706	GGDEF domain
V060002_02478	COG3437	response regulator, receiver
V060002_02479	COG0625	glutathione transferase activity
V060002_02481	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
V060002_02483	COG2195	Cleaves the N-terminal amino acid of tripeptides
V060002_02489	COG0372	Belongs to the citrate synthase family
V060002_02490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
V060002_02491	COG2186	Transcriptional regulator
V060002_02498	COG1129	ABC transporter
V060002_02503	COG0745	RESPONSE REGULATOR receiver
V060002_02504	COG2205	protein histidine kinase activity
V060002_02505	COG3713	MltA-interacting MipA family protein
V060002_02506	COG2990	Protein conserved in bacteria
V060002_02508	COG4191	Histidine kinase
V060002_02508	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_02509	COG0471	metal ion transport
V060002_02511	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V060002_02514	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_02515	COG3283	Transcriptional regulator of aromatic amino acids metabolism
V060002_02516	COG3768	UPF0283 membrane protein
V060002_02517	COG3106	COG3106 Predicted ATPase
V060002_02520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
V060002_02521	COG0494	nUDIX hydrolase
V060002_02522	COG0814	amino acid
V060002_02523	COG1760	l-serine dehydratase
V060002_02524	COG0720	synthase
V060002_02526	COG0017	Asparaginyl-tRNA synthetase
V060002_02527	COG0351	phosphomethylpyrimidine kinase
V060002_02528	COG2770	Histidine kinase
V060002_02528	COG3437	response regulator, receiver
V060002_02529	COG1448	Aminotransferase
V060002_02533	COG0840	transmembrane signaling receptor activity
V060002_02534	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
V060002_02535	COG2943	transferase activity, transferring hexosyl groups
V060002_02536	COG1609	Transcriptional regulator
V060002_02537	COG3394	polysaccharide catabolic process
V060002_02538	COG1486	melibiose metabolic process
V060002_02539	COG1447	Phosphotransferase system cellobiose-specific component IIA
V060002_02541	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
V060002_02542	COG0726	polysaccharide deacetylase
V060002_02543	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
V060002_02544	COG1846	Transcriptional regulator
V060002_02549	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
V060002_02552	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V060002_02553	COG3108	Peptidase M15
V060002_02554	COG2989	Protein conserved in bacteria
V060002_02559	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
V060002_02561	COG2814	Major facilitator Superfamily
V060002_02565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V060002_02566	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V060002_02567	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V060002_02576	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
V060002_02577	COG4139	cobalamin transport
V060002_02578	COG2988	succinylglutamate desuccinylase activity
V060002_02581	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
V060002_02582	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
V060002_02583	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_02585	COG2925	Exonuclease
V060002_02587	COG1346	cytolysis
V060002_02588	COG0295	cytidine deaminase activity
V060002_02590	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
V060002_02591	COG0500	methyltransferase
V060002_02594	COG0776	regulation of translation
V060002_02595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_02595	COG0072	phenylalanine-tRNA ligase activity
V060002_02596	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
V060002_02598	COG3706	GGDEF domain
V060002_02598	COG0745	RESPONSE REGULATOR receiver
V060002_02604	COG0322	excinuclease ABC activity
V060002_02605	COG2197	response regulator
V060002_02606	COG0417	DNA replication proofreading
V060002_02607	COG5001	Diguanylate cyclase
V060002_02609	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
V060002_02613	COG1228	amidohydrolase
V060002_02614	COG0010	Belongs to the arginase family
V060002_02615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
V060002_02616	COG2986	histidine ammonia-lyase
V060002_02620	COG0247	lactate metabolic process
V060002_02620	COG0277	FAD linked oxidase domain protein
V060002_02623	COG2885	chlorophyll binding
V060002_02627	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
V060002_02629	COG0281	malic enzyme
V060002_02631	COG2949	membrane
V060002_02632	COG3706	GGDEF domain
V060002_02633	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V060002_02635	COG0492	ferredoxin-NADP+ reductase activity
V060002_02636	COG4988	ABC transporter
V060002_02637	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
V060002_02638	COG1187	pseudouridine synthase activity
V060002_02639	COG0009	L-threonylcarbamoyladenylate synthase
V060002_02640	COG0613	PHP domain protein
V060002_02641	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
V060002_02642	COG0512	Glutamine amidotransferase of anthranilate synthase
V060002_02643	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
V060002_02644	COG0134	indole-3-glycerol-phosphate synthase activity
V060002_02644	COG0135	phosphoribosylanthranilate isomerase activity
V060002_02645	COG0133	tryptophan synthase activity
V060002_02646	COG0159	tryptophan synthase activity
V060002_02648	COG1435	thymidine kinase activity
V060002_02649	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
V060002_02650	COG1801	Protein of unknown function DUF72
V060002_02651	COG4106	trans-aconitate 2-methyltransferase activity
V060002_02652	COG0500	methyltransferase
V060002_02653	COG4067	protein conserved in archaea
V060002_02653	COG0189	ligase activity
V060002_02656	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
V060002_02658	COG3852	Histidine kinase
V060002_02661	COG3070	regulator of competence-specific genes
V060002_02663	COG2431	L-lysine efflux transmembrane transporter activity
V060002_02665	COG0076	glutamate decarboxylase activity
V060002_02666	COG1737	Transcriptional regulator
V060002_02667	COG1454	alcohol dehydrogenase
V060002_02667	COG1012	belongs to the aldehyde dehydrogenase family
V060002_02668	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
V060002_02670	COG0542	response to heat
V060002_02671	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
V060002_02672	COG1278	Cold shock
V060002_02674	COG1187	pseudouridine synthase activity
V060002_02675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
V060002_02675	COG0140	phosphoribosyl-ATP diphosphatase activity
V060002_02676	COG0107	imidazoleglycerol-phosphate synthase activity
V060002_02677	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
V060002_02678	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
V060002_02679	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V060002_02679	COG0131	Imidazoleglycerol-phosphate dehydratase
V060002_02680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
V060002_02681	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
V060002_02682	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
V060002_02683	COG1757	Na H antiporter
V060002_02684	COG2916	Histone family protein nucleoid-structuring protein H-NS
V060002_02685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_02686	COG0482	sulfurtransferase activity
V060002_02687	COG2915	High frequency lysogenization protein hflD homolog
V060002_02688	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
V060002_02690	COG2268	Band 7 protein
V060002_02692	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
V060002_02695	COG0300	oxidoreductase activity
V060002_02697	COG0501	Belongs to the peptidase M48B family
V060002_02699	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
V060002_02700	COG2226	methyltransferase
V060002_02701	COG0156	8-amino-7-oxononanoate synthase activity
V060002_02702	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V060002_02703	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
V060002_02704	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
V060002_02705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
V060002_02706	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
V060002_02708	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V060002_02709	COG2199	diguanylate cyclase activity
V060002_02709	COG2203	Gaf domain
V060002_02711	COG4120	Belongs to the binding-protein-dependent transport system permease family
V060002_02713	COG4628	conserved protein (DUF2132)
V060002_02714	COG3092	negative regulation of chromosome organization
V060002_02715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
V060002_02716	COG0857	belongs to the CobB CobQ family
V060002_02716	COG0280	phosphate acetyltransferase
V060002_02717	COG0435	Glutathione S-transferase
V060002_02718	COG4608	Belongs to the ABC transporter superfamily
V060002_02719	COG0444	Belongs to the ABC transporter superfamily
V060002_02720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_02721	COG0601	transmembrane transport
V060002_02725	COG2204	response regulator
V060002_02726	COG5001	Diguanylate cyclase
V060002_02726	COG3300	MHYT domain
V060002_02727	COG4191	Histidine kinase
V060002_02728	COG5002	protein histidine kinase activity
V060002_02730	COG2201	protein-glutamate methylesterase activity
V060002_02733	COG0009	L-threonylcarbamoyladenylate synthase
V060002_02736	COG1881	PFAM PEBP family protein
V060002_02741	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V060002_02742	COG0640	Transcriptional regulator
V060002_02743	COG3706	GGDEF domain
V060002_02747	COG1946	Acyl-CoA thioesterase
V060002_02748	COG1522	sequence-specific DNA binding
V060002_02750	COG0616	signal peptide processing
V060002_02751	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_02754	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
V060002_02755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
V060002_02757	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
V060002_02758	COG2832	Protein of unknown function (DUF454)
V060002_02760	COG0745	RESPONSE REGULATOR receiver
V060002_02761	COG0583	DNA-binding transcription factor activity
V060002_02762	COG0778	Nitroreductase
V060002_02763	COG1250	3-hydroxyacyl-CoA dehydrogenase
V060002_02763	COG1024	Enoyl-CoA hydratase
V060002_02764	COG0183	Belongs to the thiolase family
V060002_02767	COG2067	long-chain fatty acid transport protein
V060002_02769	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
V060002_02770	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
V060002_02771	COG2982	Protein involved in outer membrane biogenesis
V060002_02772	COG0572	uridine kinase
V060002_02773	COG0489	protein tyrosine kinase activity
V060002_02774	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_02774	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_02776	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
V060002_02778	COG4109	DRTGG domain
V060002_02779	COG2199	diguanylate cyclase activity
V060002_02780	COG0314	molybdopterin synthase activity
V060002_02781	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
V060002_02782	COG0315	cyclic pyranopterin monophosphate synthase activity
V060002_02783	COG0521	Mo-molybdopterin cofactor biosynthetic process
V060002_02784	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
V060002_02785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
V060002_02786	COG2198	Histidine kinase
V060002_02787	COG2204	response regulator
V060002_02788	COG0556	nucleotide-excision repair
V060002_02790	COG4657	Part of a membrane complex involved in electron transport
V060002_02791	COG2878	Part of a membrane complex involved in electron transport
V060002_02792	COG4656	Part of a membrane complex involved in electron transport
V060002_02793	COG4658	electron transport chain
V060002_02794	COG4659	FMN binding
V060002_02795	COG4660	Part of a membrane complex involved in electron transport
V060002_02796	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
V060002_02797	COG0346	lactoylglutathione lyase activity
V060002_02800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
V060002_02801	COG2056	Na+-H+ antiporter family
V060002_02802	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
V060002_02803	COG1286	toxin biosynthetic process
V060002_02804	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
V060002_02805	COG0285	dihydrofolate synthase activity
V060002_02806	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
V060002_02807	COG0101	tRNA pseudouridine synthase activity
V060002_02809	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V060002_02810	COG2190	(PTS) system
V060002_02810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_02810	COG1263	PTS System
V060002_02811	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V060002_02812	COG1940	carbohydrate kinase activity
V060002_02812	COG1846	Transcriptional regulator
V060002_02813	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V060002_02813	COG4651	solute:proton antiporter activity
V060002_02814	COG0367	asparagine synthase
V060002_02817	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
V060002_02818	COG0563	adenylate kinase activity
V060002_02819	COG0326	Molecular chaperone. Has ATPase activity
V060002_02820	COG3710	Transcriptional regulator
V060002_02821	COG3710	Transcriptional regulator
V060002_02824	COG0622	Phosphoesterase
V060002_02825	COG1090	epimerase
V060002_02826	COG0300	oxidoreductase activity
V060002_02827	COG3118	belongs to the thioredoxin family
V060002_02828	COG0330	HflC and HflK could
V060002_02829	COG1585	Membrane protein implicated in regulation of membrane protease activity
V060002_02830	COG0789	Transcriptional regulator
V060002_02833	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
V060002_02834	COG3115	cell septum assembly
V060002_02835	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
V060002_02836	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
V060002_02837	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_02839	COG2190	(PTS) system
V060002_02840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_02841	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V060002_02842	COG1702	phosphate starvation-inducible protein PhoH
V060002_02843	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
V060002_02844	COG4535	Mg2 and Co2 transporter CorC
V060002_02845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
V060002_02846	COG2888	peptidyl-tyrosine sulfation
V060002_02847	COG0495	leucyl-tRNA aminoacylation
V060002_02848	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
V060002_02849	COG1466	dna polymerase III delta subunit
V060002_02850	COG0799	negative regulation of ribosome biogenesis
V060002_02851	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
V060002_02852	COG0768	penicillin binding
V060002_02853	COG0772	Belongs to the SEDS family
V060002_02854	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
V060002_02855	COG1686	Belongs to the peptidase S11 family
V060002_02856	COG2921	Belongs to the UPF0250 family
V060002_02857	COG0321	lipoyl(octanoyl) transferase activity
V060002_02858	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
V060002_02860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
V060002_02865	COG1596	polysaccharide export
V060002_02867	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
V060002_02873	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
V060002_02875	COG0438	transferase activity, transferring glycosyl groups
V060002_02877	COG1045	serine acetyltransferase
V060002_02881	COG0110	maltose O-acetyltransferase activity
V060002_02882	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
V060002_02883	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
V060002_02886	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V060002_02892	COG0366	Alpha amylase catalytic
V060002_02893	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_02893	COG1263	PTS System
V060002_02894	COG1609	Transcriptional regulator
V060002_02895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V060002_02896	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
V060002_02897	COG2011	ABC-type metal ion transport system permease component
V060002_02898	COG1464	Belongs to the NlpA lipoprotein family
V060002_02899	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
V060002_02901	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V060002_02901	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V060002_02903	COG3706	GGDEF domain
V060002_02904	COG1611	Belongs to the LOG family
V060002_02905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V060002_02906	COG2363	Small membrane protein
V060002_02907	COG0583	DNA-binding transcription factor activity
V060002_02908	COG0301	tRNA thio-modification
V060002_02908	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V060002_02910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
V060002_02911	COG1722	exodeoxyribonuclease VII activity
V060002_02912	COG0142	geranyltranstransferase activity
V060002_02913	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
V060002_02914	COG0564	pseudouridine synthase activity
V060002_02915	COG3098	single-species biofilm formation
V060002_02918	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_02920	COG1671	Belongs to the UPF0178 family
V060002_02921	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
V060002_02922	COG0257	Belongs to the bacterial ribosomal protein bL36 family
V060002_02923	COG0254	rRNA binding
V060002_02924	COG1720	tRNA m6t6A37 methyltransferase activity
V060002_02925	COG0442	prolyl-tRNA aminoacylation
V060002_02929	COG1943	Transposase
V060002_02930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
V060002_02930	COG0047	phosphoribosylformylglycinamidine synthase activity
V060002_02931	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
V060002_02933	COG0590	tRNA wobble adenosine to inosine editing
V060002_02934	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
V060002_02940	COG0484	heat shock protein binding
V060002_02941	COG0443	Heat shock 70 kDa protein
V060002_02942	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
V060002_02943	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
V060002_02944	COG0497	DNA recombination
V060002_02945	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V060002_02946	COG2914	Belongs to the UPF0125 (RnfH) family
V060002_02947	COG2867	negative regulation of translational initiation
V060002_02948	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
V060002_02950	COG0582	viral genome integration into host DNA
V060002_02951	COG3064	Membrane
V060002_02953	COG0739	heme binding
V060002_02957	COG0840	transmembrane signaling receptor activity
V060002_02958	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
V060002_02959	COG2207	Transcriptional regulator
V060002_02961	COG1459	type II secretion system
V060002_02962	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_02966	COG4796	Type ii and iii secretion system protein
V060002_02969	COG2165	general secretion pathway protein
V060002_02971	COG3710	Transcriptional regulator
V060002_02972	COG0840	transmembrane signaling receptor activity
V060002_02973	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
V060002_02977	COG1012	belongs to the aldehyde dehydrogenase family
V060002_02988	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
V060002_02989	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
V060002_02990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
V060002_02992	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
V060002_02993	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
V060002_02994	COG3051	citrate lyase alpha subunit
V060002_02995	COG2301	Belongs to the HpcH HpaI aldolase family
V060002_02996	COG3052	prosthetic group binding
V060002_02997	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
V060002_02999	COG3630	sodium ion export across plasma membrane
V060002_03000	COG0511	ligase activity, forming carbon-carbon bonds
V060002_03000	COG5016	pyruvate
V060002_03001	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
V060002_03003	COG4565	transcriptional regulatory protein
V060002_03006	COG0583	DNA-binding transcription factor activity
V060002_03007	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V060002_03008	COG1115	amino acid carrier protein
V060002_03009	COG2015	COG2015, Alkyl sulfatase and related hydrolases
V060002_03010	COG0583	DNA-binding transcription factor activity
V060002_03012	COG1120	ATPase activity
V060002_03013	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_03014	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_03015	COG4592	Periplasmic binding protein
V060002_03017	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_03018	COG1169	isochorismate synthase
V060002_03019	COG1021	2,3-dihydroxybenzoate-AMP ligase
V060002_03020	COG3433	isochorismatase activity
V060002_03020	COG1535	isochorismatase
V060002_03021	COG1584	GPR1 FUN34 yaaH family protein
V060002_03023	COG0519	Catalyzes the synthesis of GMP from XMP
V060002_03023	COG0518	GMP synthase (glutamine-hydrolyzing) activity
V060002_03024	COG0516	GMP reductase activity
V060002_03024	COG0517	IMP dehydrogenase activity
V060002_03025	COG1570	exodeoxyribonuclease VII activity
V060002_03028	COG1160	GTP binding
V060002_03029	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V060002_03030	COG2976	Protein conserved in bacteria
V060002_03031	COG0124	histidyl-tRNA synthetase
V060002_03032	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
V060002_03034	COG0820	rRNA (adenine-C2-)-methyltransferase activity
V060002_03035	COG0105	UTP biosynthetic process
V060002_03036	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V060002_03037	COG2975	iron-sulfur cluster assembly
V060002_03038	COG0633	Ferredoxin
V060002_03039	COG0443	Heat shock 70 kDa protein
V060002_03040	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
V060002_03042	COG0822	iron-sulfur transferase activity
V060002_03043	COG1104	cysteine desulfurase activity
V060002_03044	COG1959	2 iron, 2 sulfur cluster binding
V060002_03046	COG0483	inositol monophosphate 1-phosphatase activity
V060002_03047	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_03048	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_03049	COG1862	Preprotein translocase
V060002_03050	COG0343	queuine tRNA-ribosyltransferase activity
V060002_03051	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
V060002_03052	COG0517	IMP dehydrogenase activity
V060002_03054	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
V060002_03055	COG0583	DNA-binding transcription factor activity
V060002_03056	COG0450	alkyl hydroperoxide reductase
V060002_03057	COG3142	Participates in the control of copper homeostasis
V060002_03060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
V060002_03061	COG0581	inorganic phosphate transmembrane transporter activity
V060002_03063	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
V060002_03064	COG0248	Ppx GppA phosphatase
V060002_03066	COG5002	protein histidine kinase activity
V060002_03067	COG0745	RESPONSE REGULATOR receiver
V060002_03068	COG2974	May be involved in recombination
V060002_03070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V060002_03078	COG0542	response to heat
V060002_03080	COG0564	pseudouridine synthase activity
V060002_03081	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V060002_03082	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
V060002_03083	COG1605	Chorismate mutase
V060002_03083	COG0077	Prephenate dehydratase
V060002_03084	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V060002_03085	COG5001	Diguanylate cyclase
V060002_03086	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
V060002_03087	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
V060002_03089	COG0488	(ABC) transporter
V060002_03091	COG0287	Prephenate dehydrogenase
V060002_03091	COG1605	Chorismate mutase
V060002_03092	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V060002_03093	COG3275	phosphorelay sensor kinase activity
V060002_03094	COG3279	Response regulator of the LytR AlgR family
V060002_03095	COG1472	Belongs to the glycosyl hydrolase 3 family
V060002_03096	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
V060002_03097	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
V060002_03101	COG1966	Carbon starvation protein
V060002_03102	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
V060002_03103	COG1047	Peptidyl-prolyl cis-trans
V060002_03104	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
V060002_03105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
V060002_03106	COG0196	riboflavin kinase activity
V060002_03107	COG0728	peptidoglycan biosynthetic process
V060002_03108	COG0268	Binds directly to 16S ribosomal RNA
V060002_03109	COG0640	Transcriptional regulator
V060002_03110	COG0583	DNA-binding transcription factor activity
V060002_03111	COG1283	sodium-dependent phosphate transmembrane transporter activity
V060002_03112	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
V060002_03113	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
V060002_03114	COG0730	response to heat
V060002_03115	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
V060002_03116	COG0494	nUDIX hydrolase
V060002_03117	COG3066	DNA modification
V060002_03118	COG0667	Aldo Keto reductase
V060002_03120	COG2204	response regulator
V060002_03121	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
V060002_03122	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
V060002_03124	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
V060002_03125	COG0513	Belongs to the DEAD box helicase family
V060002_03126	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
V060002_03130	COG3153	acetyltransferase
V060002_03138	COG4785	May be involved in cell division
V060002_03139	COG1185	polyribonucleotide nucleotidyltransferase activity
V060002_03140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
V060002_03141	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
V060002_03142	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
V060002_03143	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
V060002_03144	COG0195	Participates in both transcription termination and antitermination
V060002_03145	COG0779	Required for maturation of 30S ribosomal subunits
V060002_03148	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V060002_03150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
V060002_03151	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
V060002_03152	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
V060002_03153	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
V060002_03154	COG1534	Rna-binding protein
V060002_03155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V060002_03156	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V060002_03157	COG2027	D-alanyl-D-alanine carboxypeptidase
V060002_03158	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V060002_03159	COG0739	heme binding
V060002_03162	COG0316	Belongs to the HesB IscA family
V060002_03163	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
V060002_03165	COG0628	permease
V060002_03166	COG2813	Specifically methylates the guanine in position
V060002_03168	COG0747	negative chemotaxis
V060002_03169	COG0601	transmembrane transport
V060002_03170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_03171	COG0444	Belongs to the ABC transporter superfamily
V060002_03172	COG4608	Belongs to the ABC transporter superfamily
V060002_03174	COG2971	BadF BadG BcrA BcrD
V060002_03178	COG3842	ATPase activity
V060002_03180	COG1840	ABC-type Fe3 transport system, periplasmic component
V060002_03181	COG0004	ammonium transporteR
V060002_03182	COG0347	Belongs to the P(II) protein family
V060002_03183	COG3112	Uncharacterised protein family (UPF0231)
V060002_03184	COG1049	propionate catabolic process, 2-methylcitrate cycle
V060002_03185	COG1752	Esterase of the alpha-beta hydrolase superfamily
V060002_03186	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
V060002_03187	COG1643	Atp-dependent helicase
V060002_03189	COG1489	DNA binding
V060002_03190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
V060002_03191	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V060002_03193	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
V060002_03194	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
V060002_03195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
V060002_03196	COG0842	Transport permease protein
V060002_03197	COG1131	(ABC) transporter
V060002_03198	COG0659	secondary active sulfate transmembrane transporter activity
V060002_03199	COG0288	reversible hydration of carbon dioxide
V060002_03202	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
V060002_03203	COG3107	peptidoglycan biosynthetic process
V060002_03204	COG0792	nuclease activity
V060002_03205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V060002_03206	COG2823	Periplasmic or secreted lipoprotein
V060002_03207	COG2969	positive regulation of protein catabolic process
V060002_03208	COG0625	glutathione transferase activity
V060002_03209	COG2857	Cytochrome c1
V060002_03210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
V060002_03211	COG0723	plastoquinol--plastocyanin reductase activity
V060002_03212	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
V060002_03213	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
V060002_03214	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
V060002_03216	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V060002_03217	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V060002_03218	COG0335	large ribosomal subunit rRNA binding
V060002_03219	COG0336	Belongs to the RNA methyltransferase TrmD family
V060002_03220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
V060002_03221	COG0228	four-way junction DNA binding
V060002_03222	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
V060002_03223	COG4137	Cytochrome C assembly protein
V060002_03224	COG4536	flavin adenine dinucleotide binding
V060002_03225	COG1854	S-ribosylhomocysteine lyase activity
V060002_03226	COG2918	glutathione biosynthetic process
V060002_03227	COG0612	Peptidase, M16
V060002_03228	COG1238	metal cluster binding
V060002_03230	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
V060002_03231	COG5016	pyruvate
V060002_03231	COG0511	ligase activity, forming carbon-carbon bonds
V060002_03232	COG3630	sodium ion export across plasma membrane
V060002_03241	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
V060002_03242	COG0527	aspartate kinase activity
V060002_03243	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
V060002_03244	COG2137	regulation of response to DNA damage stimulus
V060002_03245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
V060002_03247	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
V060002_03248	COG4208	sulfate ABC transporter
V060002_03252	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
V060002_03253	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V060002_03254	COG1388	LysM domain
V060002_03254	COG4942	peptidase
V060002_03255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
V060002_03256	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
V060002_03257	COG0585	pseudouridine synthase activity
V060002_03258	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
V060002_03259	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
V060002_03260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
V060002_03261	COG1968	undecaprenyl-diphosphatase activity
V060002_03262	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
V060002_03263	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
V060002_03264	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
V060002_03266	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
V060002_03267	COG0828	Belongs to the bacterial ribosomal protein bS21 family
V060002_03268	COG1610	YqeY-like protein
V060002_03269	COG0358	DNA primase activity
V060002_03270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V060002_03272	COG0582	viral genome integration into host DNA
V060002_03273	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V060002_03274	COG0840	transmembrane signaling receptor activity
V060002_03275	COG2207	Transcriptional regulator
V060002_03276	COG0840	transmembrane signaling receptor activity
V060002_03278	COG2003	Belongs to the UPF0758 family
V060002_03284	COG0739	heme binding
V060002_03289	COG0328	RNA-DNA hybrid ribonuclease activity
V060002_03299	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
V060002_03300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
V060002_03301	COG1349	DNA-binding transcription factor activity
V060002_03302	COG0469	pyruvate kinase activity
V060002_03305	COG0583	DNA-binding transcription factor activity
V060002_03306	COG1279	arginine transmembrane transporter activity
V060002_03307	COG0668	transmembrane transport
V060002_03308	COG0191	fructose-bisphosphate aldolase activity
V060002_03309	COG0126	phosphoglycerate kinase activity
V060002_03310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V060002_03311	COG4771	TonB-dependent receptor
V060002_03312	COG0583	DNA-binding transcription factor activity
V060002_03313	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
V060002_03314	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
V060002_03315	COG3091	SprT-like family
V060002_03316	COG2356	endonuclease I
V060002_03317	COG1385	rRNA (uridine-N3-)-methyltransferase activity
V060002_03318	COG0189	ligase activity
V060002_03319	COG1678	Uncharacterized ACR, COG1678
V060002_03320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
V060002_03321	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V060002_03325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
V060002_03326	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
V060002_03327	COG0762	integral membrane protein
V060002_03328	COG1872	DUF167
V060002_03330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
V060002_03331	COG0635	Involved in the biosynthesis of porphyrin-containing compound
V060002_03332	COG2066	Belongs to the glutaminase family
V060002_03333	COG0220	tRNA (guanine-N7-)-methyltransferase activity
V060002_03334	COG1194	a g-specific adenine glycosylase
V060002_03335	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
V060002_03336	COG0741	lytic transglycosylase activity
V060002_03347	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
V060002_03348	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
V060002_03349	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V060002_03350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
V060002_03351	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
V060002_03352	COG2967	ApaG domain
V060002_03353	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
V060002_03355	COG3610	response to peptide
V060002_03356	COG2966	Psort location CytoplasmicMembrane, score
V060002_03357	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
V060002_03358	COG0211	Belongs to the bacterial ribosomal protein bL27 family
V060002_03359	COG0261	This protein binds to 23S rRNA in the presence of protein L20
V060002_03360	COG0142	geranyltranstransferase activity
V060002_03361	COG0531	amino acid
V060002_03362	COG0531	amino acid
V060002_03363	COG0039	L-malate dehydrogenase activity
V060002_03364	COG1438	arginine binding
V060002_03367	COG0589	response to stress
V060002_03371	COG2235	arginine
V060002_03372	COG0312	modulator of DNA gyrase
V060002_03373	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
V060002_03374	COG3164	Protein of unknown function
V060002_03375	COG1530	ribonuclease E activity
V060002_03376	COG0424	maF-like protein
V060002_03377	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
V060002_03378	COG1792	Involved in formation and maintenance of cell shape
V060002_03379	COG1077	Cell shape determining protein MreB Mrl
V060002_03388	COG1459	type II secretion system
V060002_03389	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_03391	COG3409	Peptidoglycan-binding domain 1 protein
V060002_03391	COG3267	Type II secretory pathway component ExeA
V060002_03396	COG2199	diguanylate cyclase activity
V060002_03396	COG2200	EAL domain
V060002_03397	COG0629	single-stranded DNA binding
V060002_03400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
V060002_03402	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
V060002_03403	COG0527	aspartate kinase activity
V060002_03404	COG1410	methionine synthase
V060002_03404	COG0646	methionine synthase
V060002_03418	COG0175	sulfate reduction
V060002_03419	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
V060002_03420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V060002_03424	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V060002_03425	COG0735	belongs to the Fur family
V060002_03428	COG0166	Belongs to the GPI family
V060002_03429	COG0432	Pfam Uncharacterised protein family UPF0047
V060002_03430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V060002_03431	COG0305	Participates in initiation and elongation during chromosome replication
V060002_03433	COG0359	binds to the 23S rRNA
V060002_03434	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
V060002_03435	COG2965	DNA replication, synthesis of RNA primer
V060002_03436	COG0360	Binds together with S18 to 16S ribosomal RNA
V060002_03438	COG2906	2 iron, 2 sulfur cluster binding
V060002_03439	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V060002_03440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
V060002_03441	COG0049	tRNA binding
V060002_03442	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
V060002_03444	COG2923	Belongs to the DsrF TusC family
V060002_03445	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
V060002_03446	COG2964	Protein conserved in bacteria
V060002_03447	COG0545	Peptidyl-prolyl cis-trans isomerase
V060002_03449	COG2900	Belongs to the SlyX family
V060002_03450	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
V060002_03451	COG0330	HflC and HflK could
V060002_03452	COG0330	HflC and HflK could
V060002_03453	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
V060002_03454	COG1923	regulation of RNA biosynthetic process
V060002_03455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
V060002_03456	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
V060002_03458	COG0802	atpase or kinase
V060002_03459	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
V060002_03465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
V060002_03466	COG1162	GTPase activity
V060002_03467	COG0688	phosphatidylethanolamine metabolic process
V060002_03468	COG0471	metal ion transport
V060002_03470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
V060002_03471	COG4942	peptidase
V060002_03474	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
V060002_03475	COG2816	NAD+ diphosphatase activity
V060002_03476	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
V060002_03477	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
V060002_03478	COG0085	RNA polymerase activity
V060002_03479	COG0222	ribosome binding
V060002_03480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
V060002_03481	COG0081	regulation of translation
V060002_03482	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
V060002_03483	COG0250	Participates in transcription elongation, termination and antitermination
V060002_03484	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V060002_03485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V060002_03490	COG1072	(Pantothenic acid kinase))
V060002_03492	COG0812	UDP-N-acetylmuramate dehydrogenase activity
V060002_03494	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
V060002_03503	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
V060002_03505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
V060002_03506	COG3118	belongs to the thioredoxin family
V060002_03507	COG0513	Belongs to the DEAD box helicase family
V060002_03508	COG0248	Ppx GppA phosphatase
V060002_03509	COG2205	protein histidine kinase activity
V060002_03509	COG0784	Response regulator, receiver
V060002_03510	COG2814	Major facilitator Superfamily
V060002_03513	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V060002_03514	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
V060002_03515	COG0511	ligase activity, forming carbon-carbon bonds
V060002_03516	COG0439	Biotin carboxylase
V060002_03517	COG2264	protein methyltransferase activity
V060002_03518	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V060002_03519	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
V060002_03520	COG1609	Transcriptional regulator
V060002_03521	COG0129	dihydroxy-acid dehydratase activity
V060002_03522	COG3265	gluconokinase activity
V060002_03524	COG0800	Aldolase
V060002_03528	COG0840	transmembrane signaling receptor activity
V060002_03529	COG1982	Orn Lys Arg decarboxylase major
V060002_03530	COG2131	deaminase
V060002_03543	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_03544	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
V060002_03546	COG0210	DNA helicase
V060002_03547	COG1280	lysine exporter protein (LysE YggA)
V060002_03550	COG2962	Rard protein
V060002_03551	COG0514	ATP-dependent DNA helicase (RecQ)
V060002_03554	COG1132	(ABC) transporter
V060002_03555	COG4774	siderophore transport
V060002_03556	COG1120	ATPase activity
V060002_03560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
V060002_03561	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_03561	COG1263	PTS System
V060002_03563	COG1561	YicC-like family, N-terminal region
V060002_03564	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
V060002_03565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
V060002_03566	COG1560	Kdo2-lipid A biosynthetic process
V060002_03567	COG1560	Kdo2-lipid A biosynthetic process
V060002_03568	COG1309	transcriptional regulator
V060002_03569	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
V060002_03572	COG0227	Belongs to the bacterial ribosomal protein bL28 family
V060002_03573	COG0267	Belongs to the bacterial ribosomal protein bL33 family
V060002_03575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
V060002_03576	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
V060002_03577	COG0859	PFAM glycosyl transferase family 9
V060002_03578	COG0463	Glycosyl transferase, family 2
V060002_03579	COG0859	PFAM glycosyl transferase family 9
V060002_03580	COG3642	lipopolysaccharide core region biosynthetic process
V060002_03586	COG1519	Transferase
V060002_03593	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V060002_03594	COG0662	Cupin 2, conserved barrel domain protein
V060002_03594	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
V060002_03595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
V060002_03596	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
V060002_03602	COG0318	PFAM AMP-dependent synthetase and ligase
V060002_03603	COG1454	alcohol dehydrogenase
V060002_03603	COG1012	belongs to the aldehyde dehydrogenase family
V060002_03606	COG5433	transposase activity
V060002_03607	COG5433	transposase activity
V060002_03612	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
V060002_03613	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
V060002_03614	COG0668	transmembrane transport
V060002_03615	COG1573	uracil-dna glycosylase
V060002_03617	COG3068	Protein conserved in bacteria
V060002_03619	COG1940	carbohydrate kinase activity
V060002_03620	COG1253	flavin adenine dinucleotide binding
V060002_03621	COG0776	regulation of translation
V060002_03623	COG0151	Belongs to the GarS family
V060002_03624	COG0138	bifunctional purine biosynthesis protein purh
V060002_03625	COG0789	Transcriptional regulator
V060002_03626	COG3710	Transcriptional regulator
V060002_03627	COG0531	amino acid
V060002_03628	COG1982	Orn Lys Arg decarboxylase major
V060002_03641	COG2131	deaminase
V060002_03643	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_03645	COG0747	negative chemotaxis
V060002_03654	COG1309	transcriptional regulator
V060002_03655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_03656	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V060002_03657	COG2960	long-chain fatty acid transporting porin activity
V060002_03658	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
V060002_03659	COG0583	DNA-binding transcription factor activity
V060002_03667	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
V060002_03668	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V060002_03669	COG1739	Uncharacterized protein family UPF0029
V060002_03670	COG1024	Enoyl-CoA hydratase
V060002_03670	COG1250	3-hydroxyacyl-CoA dehydrogenase
V060002_03671	COG0183	Belongs to the thiolase family
V060002_03672	COG0583	DNA-binding transcription factor activity
V060002_03673	COG2814	Major facilitator Superfamily
V060002_03674	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
V060002_03675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
V060002_03676	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
V060002_03677	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
V060002_03678	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
V060002_03679	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
V060002_03680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
V060002_03682	COG0356	it plays a direct role in the translocation of protons across the membrane
V060002_03683	COG3312	ion transport
V060002_03684	COG1475	DNA binding
V060002_03685	COG1192	Involved in chromosome partitioning
V060002_03686	COG0357	Ribosomal RNA small subunit methyltransferase G
V060002_03687	COG0445	tRNA wobble uridine modification