locus-tag	class	description
V130003_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
V130003_00020	COG0592	DNA-directed DNA polymerase activity
V130003_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
V130003_00040	COG0187	DNA topoisomerase II activity
V130003_00050	COG0187	DNA topoisomerase II activity
V130003_00060	COG3385	transposase activity
V130003_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
V130003_00090	COG3977	Valine--pyruvate aminotransferase
V130003_00100	COG0751	glycine-tRNA ligase activity
V130003_00110	COG0752	glycyl-tRNA synthetase alpha subunit
V130003_00120	COG2119	membrane
V130003_00140	COG0425	Belongs to the sulfur carrier protein TusA family
V130003_00160	COG0604	alcohol dehydrogenase
V130003_00180	COG0129	dihydroxy-acid dehydratase activity
V130003_00190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V130003_00220	COG0606	chelatase, subunit chli
V130003_00230	COG0204	Acyl-transferase
V130003_00240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V130003_00250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
V130003_00270	COG3084	Protein conserved in bacteria
V130003_00280	COG4326	sporulation control protein
V130003_00290	COG1272	protein, Hemolysin III
V130003_00310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V130003_00320	COG0569	domain protein
V130003_00330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
V130003_00330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V130003_00340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
V130003_00350	COG0242	peptide deformylase activity
V130003_00360	COG1652	LysM domain
V130003_00370	COG0758	DNA mediated transformation
V130003_00380	COG2922	Belongs to the Smg family
V130003_00390	COG0551	DNA topoisomerase type I activity
V130003_00400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
V130003_00410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
V130003_00420	COG0009	L-threonylcarbamoyladenylate synthase
V130003_00430	COG0408	coproporphyrinogen oxidase activity
V130003_00440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
V130003_00460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
V130003_00480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
V130003_00490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
V130003_00510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V130003_00520	COG2104	thiamine diphosphate biosynthetic process
V130003_00530	COG2022	thiamine diphosphate biosynthetic process
V130003_00540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V130003_00560	COG2801	Transposase and inactivated derivatives
V130003_00570	COG0006	proline dipeptidase activity
V130003_00570	COG0006	proline dipeptidase activity
V130003_00610	COG1522	sequence-specific DNA binding
V130003_00620	COG5001	Diguanylate cyclase
V130003_00620	COG5002	protein histidine kinase activity
V130003_00670	COG0589	response to stress
V130003_00680	COG1528	Iron-storage protein
V130003_00700	COG2081	HI0933 family
V130003_00720	COG1322	Protein conserved in bacteria
V130003_00730	COG2226	methyltransferase
V130003_00760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V130003_00770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V130003_00780	COG0805	protein transport
V130003_00790	COG1858	cytochrome C peroxidase
V130003_00800	COG0534	Mate efflux family protein
V130003_00820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
V130003_00830	COG2937	Belongs to the GPAT DAPAT family
V130003_00840	COG3385	transposase activity
V130003_00850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
V130003_00860	COG3161	chorismate lyase activity
V130003_00870	COG1580	Controls the rotational direction of flagella during chemotaxis
V130003_00880	COG0840	transmembrane signaling receptor activity
V130003_00900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V130003_00920	COG0084	hydrolase, TatD family'
V130003_00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V130003_00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V130003_00960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
V130003_01000	COG3078	GTPase activator activity
V130003_01030	COG3071	HemY protein
V130003_01040	COG2959	enzyme of heme biosynthesis
V130003_01050	COG1587	Uroporphyrinogen-III synthase
V130003_01060	COG0181	hydroxymethylbilane synthase activity
V130003_01080	COG1965	Belongs to the frataxin family
V130003_01100	COG0019	diaminopimelate decarboxylase activity
V130003_01110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
V130003_01130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
V130003_01140	COG1011	Hydrolase
V130003_01150	COG3287	FIST C domain
V130003_01150	COG2199	diguanylate cyclase activity
V130003_01150	COG2200	EAL domain
V130003_01180	COG0561	phosphatase activity
V130003_01190	COG2267	carboxylic ester hydrolase activity
V130003_01200	COG1280	lysine exporter protein (LysE YggA)
V130003_01210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V130003_01220	COG0783	Belongs to the Dps family
V130003_01260	COG2801	Transposase and inactivated derivatives
V130003_01290	COG0742	ribosomal rna small subunit methyltransferase
V130003_01300	COG0552	protein localization to endoplasmic reticulum
V130003_01310	COG2884	Cell division ATP-binding protein ftsE
V130003_01320	COG2177	Part of the ABC transporter FtsEX involved in
V130003_01330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V130003_01340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V130003_01400	COG2801	Transposase and inactivated derivatives
V130003_01480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V130003_01490	COG4206	TonB-dependent receptor
V130003_01520	COG1404	Belongs to the peptidase S8 family
V130003_01530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
V130003_01550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
V130003_01560	COG3300	MHYT domain
V130003_01560	COG5001	Diguanylate cyclase
V130003_01580	COG3852	Histidine kinase
V130003_01600	COG0174	glutamine synthetase
V130003_01610	COG1217	gtp-binding protein TYPA
V130003_01620	COG1660	Displays ATPase and GTPase activities
V130003_01630	COG1295	ribonuclease BN
V130003_01640	COG1490	D-aminoacyl-tRNA deacylase activity
V130003_01650	COG0456	acetyltransferase
V130003_01670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
V130003_01680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
V130003_01690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
V130003_01700	COG3031	protein transport across the cell outer membrane
V130003_01720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V130003_01730	COG1459	type II secretion system
V130003_01740	COG2165	general secretion pathway protein
V130003_01750	COG2165	general secretion pathway protein
V130003_01760	COG2165	general secretion pathway protein
V130003_01770	COG4795	General secretion pathway protein
V130003_01780	COG3156	type II secretion system protein K
V130003_01790	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V130003_01800	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V130003_01810	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V130003_01830	COG1218	3'(2'),5'-bisphosphate nucleotidase
V130003_01840	COG0494	nUDIX hydrolase
V130003_01860	COG1040	competence protein
V130003_01870	COG0596	Alpha beta hydrolase
V130003_01890	COG2183	response to ionizing radiation
V130003_01900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V130003_01930	COG1129	ABC transporter
V130003_01940	COG1172	Belongs to the binding-protein-dependent transport system permease family
V130003_01950	COG1472	Belongs to the glycosyl hydrolase 3 family
V130003_01990	COG2233	PERMEase
V130003_02000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
V130003_02010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V130003_02020	COG1758	RNA polymerase activity
V130003_02030	COG0194	GDP metabolic process
V130003_02040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
V130003_02050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V130003_02090	COG4232	protein-disulfide reductase activity
V130003_02110	COG3385	transposase activity
V130003_02120	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V130003_02130	COG1027	Aspartate ammonia-lyase
V130003_02150	COG3706	GGDEF domain
V130003_02160	COG3030	protein affecting phage T7 exclusion by the F plasmid
V130003_02170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
V130003_02190	COG2205	protein histidine kinase activity
V130003_02200	COG0745	RESPONSE REGULATOR receiver
V130003_02220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
V130003_02230	COG0205	6-phosphofructokinase activity
V130003_02240	COG1494	fructose-1,6-bisphosphatase
V130003_02250	COG3074	FtsZ-dependent cytokinesis
V130003_02260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
V130003_02270	COG0527	aspartate kinase activity
V130003_02270	COG0460	homoserine dehydrogenase
V130003_02280	COG0626	cystathionine gamma-synthase activity
V130003_02290	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
V130003_02300	COG0281	malic enzyme
V130003_02310	COG0254	rRNA binding
V130003_02320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
V130003_02330	COG1609	Transcriptional regulator
V130003_02340	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
V130003_02350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
V130003_02360	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
V130003_02370	COG1575	Belongs to the MenA family. Type 1 subfamily
V130003_02380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V130003_02390	COG0534	Mate efflux family protein
V130003_02400	COG0149	triose-phosphate isomerase activity
V130003_02450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
V130003_02460	COG0459	protein refolding
V130003_02480	COG3344	reverse transcriptase
V130003_02530	COG3385	transposase activity
V130003_02550	COG1509	lysine 2,3-aminomutase activity
V130003_02560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
V130003_02580	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
V130003_02590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
V130003_02600	COG1053	succinate dehydrogenase
V130003_02610	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
V130003_02620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V130003_02630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
V130003_02640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
V130003_02650	COG1045	serine acetyltransferase
V130003_02670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
V130003_02680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
V130003_02690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
V130003_02700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
V130003_02710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V130003_02720	COG0137	argininosuccinate synthase activity
V130003_02730	COG0165	Argininosuccinate lyase
V130003_02750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V130003_02760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
V130003_02760	COG0678	peroxiredoxin activity
V130003_02780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
V130003_02840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
V130003_02850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
V130003_02870	COG0338	D12 class N6 adenine-specific DNA methyltransferase
V130003_02880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
V130003_02890	COG0546	phosphoglycolate phosphatase activity
V130003_02900	COG0180	Tryptophanyl-tRNA synthetase
V130003_02930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V130003_02950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
V130003_03000	COG2801	Transposase and inactivated derivatives
V130003_03020	COG3954	Phosphoribulokinase
V130003_03040	COG0429	hydrolase of the alpha beta-hydrolase fold
V130003_03060	COG0488	(ABC) transporter
V130003_03070	COG2249	NAD(P)H dehydrogenase (quinone) activity
V130003_03100	COG1047	Peptidyl-prolyl cis-trans
V130003_03120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
V130003_03130	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
V130003_03140	COG3083	sulfuric ester hydrolase activity
V130003_03150	COG0557	exoribonuclease II activity
V130003_03160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
V130003_03170	COG0051	transcription antitermination factor activity, RNA binding
V130003_03180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
V130003_03190	COG0088	Forms part of the polypeptide exit tunnel
V130003_03200	COG0089	rRNA binding
V130003_03210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
V130003_03220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
V130003_03230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
V130003_03240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
V130003_03250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
V130003_03260	COG0255	Belongs to the universal ribosomal protein uL29 family
V130003_03270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
V130003_03280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
V130003_03290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
V130003_03300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
V130003_03310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
V130003_03320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
V130003_03340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
V130003_03350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
V130003_03360	COG1841	ribosomal large subunit assembly
V130003_03380	COG0201	protein transport
V130003_03390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
V130003_03400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
V130003_03410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
V130003_03420	COG0202	RNA polymerase activity
V130003_03430	COG0203	ribosomal protein L17
V130003_03450	COG0545	Peptidyl-prolyl cis-trans isomerase
V130003_03460	COG3061	Opacity-associated protein A
V130003_03460	COG3266	domain, Protein
V130003_03470	COG0697	spore germination
V130003_03480	COG2153	protein acetylation
V130003_03490	COG0513	Belongs to the DEAD box helicase family
V130003_03510	COG0737	Belongs to the 5'-nucleotidase family
V130003_03520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
V130003_03520	COG1648	precorrin-2 dehydrogenase activity
V130003_03530	COG0175	sulfate reduction
V130003_03540	COG2895	sulfate adenylyltransferase (ATP) activity
V130003_03550	COG0529	Catalyzes the synthesis of activated sulfate
V130003_03590	COG0577	efflux transmembrane transporter activity
V130003_03590	COG1136	(ABC) transporter
V130003_03620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
V130003_03630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V130003_03640	COG0729	surface antigen
V130003_03660	COG2105	PFAM AIG2 family protein
V130003_03670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
V130003_03690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V130003_03700	COG0163	prenyltransferase activity
V130003_03720	COG1178	ABC-type Fe3 transport system permease component
V130003_03730	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
V130003_03740	COG3028	Belongs to the UPF0307 family
V130003_03750	COG0312	modulator of DNA gyrase
V130003_03760	COG2239	Acts as a magnesium transporter
V130003_03770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V130003_03780	COG1660	Displays ATPase and GTPase activities
V130003_03790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V130003_03800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
V130003_03820	COG1137	ATPase activity
V130003_03830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
V130003_03860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
V130003_03860	COG0517	IMP dehydrogenase activity
V130003_03880	COG1127	ABC transporter
V130003_03890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
V130003_03900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V130003_03910	COG2854	intermembrane phospholipid transfer
V130003_03930	COG5007	Belongs to the BolA IbaG family
V130003_03940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
V130003_03960	COG0251	oxidation-reduction process
V130003_03980	COG0540	Belongs to the ATCase OTCase family
V130003_04000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
V130003_04010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
V130003_04020	COG0564	pseudouridine synthase activity
V130003_04030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V130003_04040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V130003_04050	COG3385	transposase activity
V130003_04060	COG0525	valine-tRNA ligase activity
V130003_04080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V130003_04090	COG0795	lipopolysaccharide-transporting ATPase activity
V130003_04100	COG0795	lipopolysaccharide-transporting ATPase activity
V130003_04120	COG3437	response regulator, receiver
V130003_04140	COG0066	3-isopropylmalate dehydratase activity
V130003_04150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
V130003_04160	COG0473	3-isopropylmalate dehydrogenase activity
V130003_04210	COG0583	DNA-binding transcription factor activity
V130003_04220	COG1022	Amp-dependent synthetase and ligase
V130003_04230	COG0028	Belongs to the TPP enzyme family
V130003_04240	COG0440	acetolactate synthase activity
V130003_04250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V130003_04260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
V130003_04270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
V130003_04280	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
V130003_04290	COG3079	Belongs to the UPF0149 family
V130003_04300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V130003_04310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V130003_04340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
V130003_04360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
V130003_04370	COG1595	DNA-templated transcription, initiation
V130003_04400	COG3086	response to oxidative stress
V130003_04410	COG0481	GTPase activity
V130003_04430	COG0571	ribonuclease III activity
V130003_04440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
V130003_04450	COG1381	Involved in DNA repair and RecF pathway recombination
V130003_04460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
V130003_04540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V130003_04550	COG3956	TIGRFAM MazG family protein
V130003_04560	COG0504	CTP synthase activity
V130003_04570	COG0148	phosphopyruvate hydratase activity
V130003_04580	COG0617	tRNA 3'-terminal CCA addition
V130003_04590	COG3267	Type II secretory pathway component ExeA
V130003_04590	COG3409	Peptidoglycan-binding domain 1 protein
V130003_04610	COG4991	sh3 domain protein
V130003_04620	COG0306	phosphate transporter
V130003_04630	COG1392	Phosphate transport regulator
V130003_04640	COG3025	triphosphatase activity
V130003_04650	COG3385	transposase activity
V130003_04660	COG0840	transmembrane signaling receptor activity
V130003_04670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V130003_04690	COG1538	Outer membrane efflux protein
V130003_04700	COG0494	nUDIX hydrolase
V130003_04710	COG3151	Protein conserved in bacteria
V130003_04730	COG3150	esterase
V130003_04740	COG0187	DNA topoisomerase II activity
V130003_04750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
V130003_04770	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
V130003_04780	COG0237	dephospho-CoA kinase activity
V130003_04800	COG1459	type II secretion system
V130003_04810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V130003_04850	COG0716	FMN binding
V130003_04860	COG4974	Belongs to the 'phage' integrase family
V130003_04870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V130003_04880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
V130003_04890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
V130003_04900	COG0737	Belongs to the 5'-nucleotidase family
V130003_04910	COG2186	Transcriptional regulator
V130003_04920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
V130003_04930	COG0508	dehydrogenase complex catalyzes the overall conversion of
V130003_04940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V130003_04960	COG3116	cell division
V130003_04970	COG0768	penicillin binding
V130003_04980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
V130003_04990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
V130003_05010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
V130003_05020	COG0772	Belongs to the SEDS family
V130003_05030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
V130003_05040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V130003_05050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
V130003_05060	COG0849	cell division
V130003_05070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
V130003_05080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
V130003_05100	COG0653	protein targeting
V130003_05110	COG0494	nUDIX hydrolase
V130003_05120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
V130003_05140	COG0505	Belongs to the CarA family
V130003_05150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
V130003_05180	COG2801	Transposase and inactivated derivatives
V130003_05210	COG0730	response to heat
V130003_05220	COG0583	DNA-binding transcription factor activity
V130003_05230	COG2860	membrane
V130003_05240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
V130003_05260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
V130003_05280	COG0493	'glutamate synthase
V130003_05290	COG0067	glutamate synthase
V130003_05290	COG0069	glutamate synthase activity
V130003_05290	COG0070	glutamate synthase
V130003_05310	COG0067	glutamate synthase
V130003_05310	COG0069	glutamate synthase activity
V130003_05310	COG0070	glutamate synthase
V130003_05320	COG1242	4 iron, 4 sulfur cluster binding
V130003_05330	COG5001	Diguanylate cyclase
V130003_05330	COG4251	negative regulation of phosphorylation
V130003_05330	COG3706	GGDEF domain
V130003_05330	COG2203	Gaf domain
V130003_05340	COG5002	protein histidine kinase activity
V130003_05340	COG2198	Histidine kinase
V130003_05340	COG0784	Response regulator, receiver
V130003_05350	COG0784	Response regulator, receiver
V130003_05350	COG2198	Histidine kinase
V130003_05350	COG5002	protein histidine kinase activity
V130003_05360	COG0745	RESPONSE REGULATOR receiver
V130003_05380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V130003_05410	COG0083	homoserine kinase activity
V130003_05420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
V130003_05430	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
V130003_05440	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
V130003_05450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
V130003_05480	COG1115	amino acid carrier protein
V130003_05490	COG3022	response to hydroperoxide
V130003_05510	COG0084	hydrolase, TatD family'
V130003_05520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V130003_05530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
V130003_05540	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
V130003_05550	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
V130003_05560	COG0813	purine-nucleoside phosphorylase activity
V130003_05580	COG0560	Phosphoserine phosphatase
V130003_05600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
V130003_05610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
V130003_05620	COG1022	Amp-dependent synthetase and ligase
V130003_05660	COG3250	beta-galactosidase activity
V130003_05670	COG1609	Transcriptional regulator
V130003_05680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V130003_05710	COG0189	ligase activity
V130003_05710	COG0569	domain protein
V130003_05750	COG2171	N-acyltransferase activity
V130003_05760	COG3141	response to X-ray
V130003_05790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
V130003_05800	COG1074	ATP-dependent DNA helicase activity
V130003_05810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
V130003_05830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
V130003_05830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V130003_05850	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
V130003_05860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
V130003_05870	COG2166	iron-sulfur cluster assembly
V130003_05880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V130003_05900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
V130003_05910	COG3248	Nucleoside-binding outer membrane protein
V130003_05930	COG1595	DNA-templated transcription, initiation
V130003_05950	COG2211	Major facilitator Superfamily
V130003_05960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V130003_05980	COG2813	Specifically methylates the guanine in position
V130003_05990	COG0271	Belongs to the BolA IbaG family
V130003_06000	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V130003_06010	COG1805	sodium ion transport
V130003_06020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V130003_06030	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V130003_06040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V130003_06050	COG2871	sodium ion transport
V130003_06060	COG1477	protein flavinylation
V130003_06100	COG3706	GGDEF domain
V130003_06110	COG0733	neurotransmitter:sodium symporter activity
V130003_06120	COG3385	transposase activity
V130003_06150	COG0189	ligase activity
V130003_06160	COG4067	protein conserved in archaea
V130003_06160	COG0189	ligase activity
V130003_06170	COG2195	Cleaves the N-terminal amino acid of tripeptides
V130003_06180	COG2252	PERMEase
V130003_06190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
V130003_06200	COG1073	alpha beta
V130003_06220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
V130003_06230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
V130003_06240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
V130003_06250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
V130003_06260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V130003_06260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V130003_06290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
V130003_06300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V130003_06310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
V130003_06320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
V130003_06340	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
V130003_06350	COG0024	Methionine aminopeptidase
V130003_06360	COG0052	Belongs to the universal ribosomal protein uS2 family
V130003_06370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
V130003_06380	COG0528	UMP kinase activity
V130003_06390	COG0233	cytoplasmic translational termination
V130003_06400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
V130003_06410	COG0575	Belongs to the CDS family
V130003_06420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
V130003_06430	COG0750	zinc metalloprotease
V130003_06450	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
V130003_06460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V130003_06470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V130003_06480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V130003_06490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V130003_06500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
V130003_06510	COG0587	DNA-directed DNA polymerase activity
V130003_06520	COG0825	malonyl-CoA metabolic process
V130003_06530	COG0037	tRNA processing
V130003_06540	COG0037	tRNA processing
V130003_06560	COG3479	Phenolic acid decarboxylase
V130003_06570	COG0347	Belongs to the P(II) protein family
V130003_06580	COG3021	interspecies interaction between organisms
V130003_06590	COG0741	lytic transglycosylase activity
V130003_06590	COG1388	LysM domain
V130003_06600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V130003_06610	COG2226	methyltransferase
V130003_06620	COG0328	RNA-DNA hybrid ribonuclease activity
V130003_06650	COG1960	acyl-CoA dehydrogenase activity
V130003_06660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V130003_06670	COG0121	glutamine amidotransferase
V130003_06680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
V130003_06690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
V130003_06700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
V130003_06720	COG1187	pseudouridine synthase activity
V130003_06730	COG2840	Smr protein MutS2
V130003_06770	COG2217	Heavy metal translocating P-type atpase
V130003_06770	COG2608	mercury ion transmembrane transporter activity
V130003_06780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V130003_06830	COG1629	transport
V130003_06830	COG4774	siderophore transport
V130003_06840	COG2375	cellular response to nickel ion
V130003_06850	COG2226	methyltransferase
V130003_06850	COG3433	isochorismatase activity
V130003_06850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V130003_06920	COG0784	Response regulator, receiver
V130003_06920	COG0835	chemotaxis
V130003_06930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V130003_06940	COG1815	bacterial-type flagellum-dependent cell motility
V130003_06970	COG1749	Flagellar hook protein flgE
V130003_06980	COG4787	bacterial-type flagellum-dependent cell motility
V130003_07000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
V130003_07010	COG1706	bacterial-type flagellum-dependent cell motility
V130003_07020	COG1705	Flagellar rod assembly protein muramidase FlgJ
V130003_07020	COG3951	Flagellar rod assembly protein muramidase FlgJ
V130003_07050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V130003_07060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V130003_07070	COG0012	GTP binding
V130003_07080	COG0193	aminoacyl-tRNA hydrolase activity
V130003_07090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
V130003_07100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
V130003_07110	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
V130003_07120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
V130003_07130	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
V130003_07140	COG2890	protein-(glutamine-N5) methyltransferase activity
V130003_07160	COG2912	Transglutaminase-like superfamily
V130003_07170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
V130003_07180	COG0737	Belongs to the 5'-nucleotidase family
V130003_07190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
V130003_07200	COG2233	PERMEase
V130003_07240	COG1393	Belongs to the ArsC family
V130003_07250	COG4783	chaperone-mediated protein folding
V130003_07290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
V130003_07320	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
V130003_07340	COG1876	peptidase activity
V130003_07360	COG1393	Belongs to the ArsC family
V130003_07400	COG2837	iron assimilation
V130003_07410	COG2706	6-phosphogluconolactonase activity
V130003_07430	COG0800	Aldolase
V130003_07450	COG4145	pantothenate transmembrane transporter activity
V130003_07470	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
V130003_07490	COG1737	Transcriptional regulator
V130003_07490	COG0837	glucose binding
V130003_07500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V130003_07510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V130003_07520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V130003_07530	COG1334	flagellar protein FlaG
V130003_07540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
V130003_07560	COG1516	flagellar protein fliS
V130003_07600	COG1677	Flagellar hook-basal body complex protein FliE
V130003_07620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
V130003_07630	COG1317	bacterial-type flagellum organization
V130003_07670	COG1580	Controls the rotational direction of flagella during chemotaxis
V130003_07730	COG1987	bacterial-type flagellum assembly
V130003_07740	COG1684	flagellar biosynthetic protein fliR
V130003_07760	COG2840	Smr protein MutS2
V130003_07770	COG2890	protein-(glutamine-N5) methyltransferase activity
V130003_07780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
V130003_07790	COG2860	membrane
V130003_07800	COG3101	peptidyl-lysine hydroxylation
V130003_07820	COG0431	NADPH-dependent FMN reductase
V130003_07830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
V130003_07830	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
V130003_07840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V130003_07850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V130003_07860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V130003_07870	COG0735	belongs to the Fur family
V130003_07890	COG0583	DNA-binding transcription factor activity
V130003_07910	COG1346	cytolysis
V130003_07940	COG0596	Alpha beta hydrolase
V130003_07950	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
V130003_07960	COG0033	Phosphoglucomutase
V130003_07980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
V130003_07990	COG0372	Belongs to the citrate synthase family
V130003_08010	COG2009	succinate dehydrogenase
V130003_08020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
V130003_08030	COG1053	succinate dehydrogenase
V130003_08050	COG0567	Dehydrogenase, E1 component
V130003_08060	COG0508	dehydrogenase complex catalyzes the overall conversion of
V130003_08070	COG0045	succinate-CoA ligase (ADP-forming) activity
V130003_08080	COG0045	succinate-CoA ligase (ADP-forming) activity
V130003_08100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
V130003_08110	COG1121	(ABC) transporter
V130003_08120	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
V130003_08130	COG4977	sequence-specific DNA binding
V130003_08150	COG1918	ferrous iron import across plasma membrane
V130003_08190	COG0018	arginyl-trna synthetase
V130003_08210	COG1025	Belongs to the peptidase M16 family
V130003_08220	COG2062	phosphohistidine phosphatase, SixA
V130003_08280	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
V130003_08290	COG0643	Histidine kinase
V130003_08290	COG0784	Response regulator, receiver
V130003_08290	COG2198	Histidine kinase
V130003_08300	COG2201	protein-glutamate methylesterase activity
V130003_08310	COG1192	Involved in chromosome partitioning
V130003_08330	COG0835	chemotaxis
V130003_08350	COG4133	protoheme IX ABC transporter activity
V130003_08360	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V130003_08370	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V130003_08380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V130003_08400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
V130003_08410	COG1138	Cytochrome C-type biogenesis protein
V130003_08420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
V130003_08430	COG3088	subunit of a heme lyase
V130003_08430	COG4235	cytochrome complex assembly
V130003_08450	COG2853	Lipoprotein
V130003_08490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
V130003_08500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V130003_08510	COG0123	including yeast histone deacetylase and acetoin utilization protein
V130003_08520	COG3083	sulfuric ester hydrolase activity
V130003_08530	COG3082	Protein of unknown function (DUF1414)
V130003_08540	COG3081	Nucleoid-associated protein
V130003_08580	COG1757	Na H antiporter
V130003_08590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V130003_08600	COG2095	MarC family integral membrane protein
V130003_08610	COG1012	belongs to the aldehyde dehydrogenase family
V130003_08610	COG1454	alcohol dehydrogenase
V130003_08630	COG0659	secondary active sulfate transmembrane transporter activity
V130003_08640	COG1530	ribonuclease E activity
V130003_08650	COG0564	pseudouridine synthase activity
V130003_08660	COG0424	maF-like protein
V130003_08670	COG1399	metal-binding, possibly nucleic acid-binding protein
V130003_08680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
V130003_08690	COG0416	fatty acid biosynthetic process
V130003_08700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
V130003_08720	COG1028	Short-chain dehydrogenase reductase Sdr
V130003_08730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
V130003_08740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V130003_08750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V130003_08760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
V130003_08770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
V130003_08790	COG0084	hydrolase, TatD family'
V130003_08800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V130003_08800	COG1263	PTS System
V130003_08810	COG0733	neurotransmitter:sodium symporter activity
V130003_08830	COG4667	esterase of the alpha-beta hydrolase superfamily
V130003_08850	COG1940	carbohydrate kinase activity
V130003_08860	COG0784	Response regulator, receiver
V130003_08860	COG0835	chemotaxis
V130003_08890	COG2226	methyltransferase
V130003_08910	COG0676	glucose-6-phosphate 1-epimerase activity
V130003_08920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V130003_08930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V130003_08950	COG3139	Protein of unknown function (DUF1315)
V130003_08960	COG0252	asparaginase activity
V130003_08970	COG0616	signal peptide processing
V130003_08980	COG0616	signal peptide processing
V130003_08990	COG0446	pyridine nucleotide-disulphide oxidoreductase
V130003_08990	COG1902	pentaerythritol trinitrate reductase activity
V130003_09000	COG0788	formyltetrahydrofolate deformylase activity
V130003_09020	COG1199	ATP-dependent helicase activity
V130003_09030	COG1214	PFAM Peptidase M22, glycoprotease
V130003_09060	COG0596	Alpha beta hydrolase
V130003_09070	COG0318	PFAM AMP-dependent synthetase and ligase
V130003_09080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
V130003_09110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
V130003_09120	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
V130003_09130	COG0436	Aminotransferase
V130003_09140	COG1169	isochorismate synthase
V130003_09150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
V130003_09160	COG0596	Alpha beta hydrolase
V130003_09200	COG3135	benzoate transporter
V130003_09250	COG3015	lipoprotein NlpE involved in copper resistance
V130003_09260	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
V130003_09270	COG2894	cell division
V130003_09280	COG0850	regulation of cytokinetic process
V130003_09290	COG3100	YcgL domain-containing protein
V130003_09300	COG2951	lytic endotransglycosylase activity
V130003_09320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V130003_09330	COG3005	denitrification pathway
V130003_09340	COG0243	molybdopterin cofactor binding
V130003_09370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V130003_09390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
V130003_09570	COG4589	Belongs to the CDS family
V130003_09590	COG3300	MHYT domain
V130003_09590	COG5001	Diguanylate cyclase
V130003_09630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
V130003_09640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
V130003_09650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
V130003_09660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
V130003_09680	COG4191	Histidine kinase
V130003_09690	COG0544	peptidyl-prolyl cis-trans isomerase activity
V130003_09710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
V130003_09720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
V130003_09730	COG0776	regulation of translation
V130003_09740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V130003_09750	COG1555	photosystem II stabilization
V130003_09760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
V130003_09770	COG0539	negative regulation of cytoplasmic translation
V130003_09780	COG0776	regulation of translation
V130003_09790	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
V130003_09800	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
V130003_09820	COG0601	transmembrane transport
V130003_09830	COG4239	(ABC) transporter, permease
V130003_09840	COG0747	negative chemotaxis
V130003_09850	COG0444	Belongs to the ABC transporter superfamily
V130003_09860	COG4608	Belongs to the ABC transporter superfamily
V130003_09920	COG0583	DNA-binding transcription factor activity
V130003_09940	COG0686	Belongs to the AlaDH PNT family
V130003_09960	COG1674	ftsk spoiiie
V130003_09970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
V130003_09980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V130003_09990	COG2186	Transcriptional regulator
V130003_10020	COG0537	adenosine 5'-monophosphoramidase activity
V130003_10070	COG3150	esterase
V130003_10080	COG1252	NADH dehydrogenase
V130003_10120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
V130003_10130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
V130003_10150	COG4591	ABC-type transport system involved in lipoprotein release permease component
V130003_10160	COG1136	(ABC) transporter
V130003_10170	COG4591	ABC-type transport system involved in lipoprotein release permease component
V130003_10190	COG0658	competence protein
V130003_10190	COG2333	competence protein COMEC
V130003_10200	COG1132	(ABC) transporter
V130003_10210	COG1663	tetraacyldisaccharide 4'-kinase activity
V130003_10220	COG2835	tetraacyldisaccharide 4'-kinase activity
V130003_10230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
V130003_10250	COG2719	SpoVR family
V130003_10260	COG2718	Belongs to the UPF0229 family
V130003_10270	COG2766	serine protein kinase
V130003_10280	COG3013	Belongs to the UPF0304 family
V130003_10310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
V130003_10320	COG0840	transmembrane signaling receptor activity
V130003_10340	COG1882	Formate acetyltransferase
V130003_10410	COG4160	amino acid transport
V130003_10420	COG0708	Exodeoxyribonuclease III
V130003_10430	COG0840	transmembrane signaling receptor activity
V130003_10440	COG0840	transmembrane signaling receptor activity
V130003_10460	COG3923	Primosomal replication protein n
V130003_10470	COG0730	response to heat
V130003_10480	COG1199	ATP-dependent helicase activity
V130003_10490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V130003_10500	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V130003_10510	COG3012	SEC-C Motif Domain Protein
V130003_10520	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V130003_10530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V130003_10540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V130003_10550	COG0215	cysteine-tRNA ligase activity
V130003_10560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
V130003_10570	COG0632	four-way junction helicase activity
V130003_10600	COG1271	oxidase subunit
V130003_10610	COG1294	oxidase, subunit
V130003_10630	COG0824	Thioesterase
V130003_10640	COG0811	peptide transport
V130003_10670	COG0823	Involved in the tonB-independent uptake of proteins
V130003_10680	COG2885	chlorophyll binding
V130003_10700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
V130003_10720	COG0784	Response regulator, receiver
V130003_10720	COG5002	protein histidine kinase activity
V130003_10740	COG1012	belongs to the aldehyde dehydrogenase family
V130003_10760	COG3284	Transcriptional regulator
V130003_10770	COG4628	conserved protein (DUF2132)
V130003_10790	COG0415	Belongs to the DNA photolyase family
V130003_10800	COG0415	Belongs to the DNA photolyase family
V130003_10840	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
V130003_10850	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
V130003_10860	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
V130003_10880	COG4932	domain protein
V130003_10880	COG5492	domain, Protein
V130003_10890	COG3335	DDE superfamily endonuclease
V130003_10940	COG2267	carboxylic ester hydrolase activity
V130003_10970	COG3064	Membrane
V130003_11210	COG4789	Type iii secretion
V130003_11220	COG4792	protein secretion
V130003_11280	COG3710	Transcriptional regulator
V130003_11300	COG4790	Type iii secretion
V130003_11460	COG0582	viral genome integration into host DNA
V130003_11470	COG0582	viral genome integration into host DNA
V130003_11490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V130003_11510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V130003_11510	COG3008	intermembrane lipid transfer
V130003_11520	COG2995	paraquat-inducible protein a
V130003_11540	COG1309	transcriptional regulator
V130003_11550	COG1012	belongs to the aldehyde dehydrogenase family
V130003_11600	COG1960	acyl-CoA dehydrogenase activity
V130003_11610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V130003_11620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
V130003_11630	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
V130003_11640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
V130003_11670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V130003_11680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V130003_11690	COG0297	glycogen (starch) synthase activity
V130003_11730	COG3070	regulator of competence-specific genes
V130003_11740	COG1609	Transcriptional regulator
V130003_11760	COG0745	RESPONSE REGULATOR receiver
V130003_11770	COG1434	Gram-negative-bacterium-type cell wall biogenesis
V130003_11780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V130003_11790	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
V130003_11800	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
V130003_11820	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
V130003_11850	COG1032	radical SAM domain protein
V130003_11860	COG5001	Diguanylate cyclase
V130003_11870	COG0612	Peptidase, M16
V130003_11900	COG0583	DNA-binding transcription factor activity
V130003_11910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
V130003_11930	COG2350	Protein conserved in bacteria
V130003_11940	COG1607	acyl-coa hydrolase
V130003_11980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V130003_12000	COG2116	formate transmembrane transporter activity
V130003_12010	COG4459	periplasmic nitrate reductase
V130003_12020	COG3005	denitrification pathway
V130003_12030	COG0243	molybdopterin cofactor binding
V130003_12060	COG1227	inorganic diphosphatase activity
V130003_12090	COG4172	Belongs to the ABC transporter superfamily
V130003_12130	COG4168	peptide transport system, permease
V130003_12150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
V130003_12160	COG1842	Phage shock protein A
V130003_12190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V130003_12220	COG2818	Glycosylase
V130003_12230	COG0589	response to stress
V130003_12270	COG0733	neurotransmitter:sodium symporter activity
V130003_12280	COG0564	pseudouridine synthase activity
V130003_12290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
V130003_12300	COG4136	ATPase activity
V130003_12310	COG4135	transport system, permease component
V130003_12320	COG4134	Bacterial extracellular solute-binding protein
V130003_12340	COG3313	Fe-S protein
V130003_12360	COG0842	Transport permease protein
V130003_12370	COG1131	(ABC) transporter
V130003_12380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V130003_12390	COG0814	amino acid
V130003_12410	COG2239	Acts as a magnesium transporter
V130003_12430	COG2205	protein histidine kinase activity
V130003_12430	COG0784	Response regulator, receiver
V130003_12460	COG4934	collagen metabolic process
V130003_12510	COG2801	Transposase and inactivated derivatives
V130003_12540	COG0840	transmembrane signaling receptor activity
V130003_12560	COG5001	Diguanylate cyclase
V130003_12560	COG4251	negative regulation of phosphorylation
V130003_12560	COG3706	GGDEF domain
V130003_12560	COG2203	Gaf domain
V130003_12570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
V130003_12610	COG1061	Type III restriction enzyme res subunit
V130003_12620	COG1187	pseudouridine synthase activity
V130003_12630	COG2814	Major facilitator Superfamily
V130003_12650	COG0702	epimerase
V130003_12660	COG0534	Mate efflux family protein
V130003_12680	COG4181	ATPase activity
V130003_12690	COG0577	efflux transmembrane transporter activity
V130003_12710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V130003_12730	COG1748	Saccharopine dehydrogenase
V130003_12760	COG1538	Outer membrane efflux protein
V130003_12800	COG0583	DNA-binding transcription factor activity
V130003_12820	COG1451	nucleotide metabolic process
V130003_12850	COG3063	Type IV pilus biogenesis stability protein PilW
V130003_12860	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
V130003_12870	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
V130003_12910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V130003_12940	COG3290	protein histidine kinase activity
V130003_12950	COG4565	transcriptional regulatory protein
V130003_12970	COG0784	Response regulator, receiver
V130003_12970	COG0835	chemotaxis
V130003_13030	COG1085	galactose-1-phosphate uridylyltransferase
V130003_13040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
V130003_13050	COG2017	converts alpha-aldose to the beta-anomer
V130003_13070	COG1028	Short-chain dehydrogenase reductase Sdr
V130003_13090	COG3527	Alpha-acetolactate decarboxylase
V130003_13120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
V130003_13140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V130003_13180	COG3097	Belongs to the UPF0267 family
V130003_13230	COG1271	oxidase subunit
V130003_13240	COG1294	oxidase, subunit
V130003_13250	COG1136	(ABC) transporter
V130003_13250	COG4591	ABC-type transport system involved in lipoprotein release permease component
V130003_13260	COG0577	efflux transmembrane transporter activity
V130003_13260	COG1136	(ABC) transporter
V130003_13270	COG0577	efflux transmembrane transporter activity
V130003_13270	COG1136	(ABC) transporter
V130003_13310	COG0583	DNA-binding transcription factor activity
V130003_13330	COG2723	6-phospho-beta-galactosidase activity
V130003_13340	COG1609	Transcriptional regulator
V130003_13350	COG0251	oxidation-reduction process
V130003_13370	COG0584	glycerophosphoryl diester phosphodiesterase
V130003_13380	COG1349	DNA-binding transcription factor activity
V130003_13390	COG3842	ATPase activity
V130003_13400	COG0395	ABC-type sugar transport system, permease component
V130003_13410	COG1175	transmembrane transport
V130003_13440	COG0811	peptide transport
V130003_13450	COG0811	peptide transport
V130003_13460	COG0848	biopolymer transport protein
V130003_13470	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
V130003_13490	COG1793	dna ligase
V130003_13510	COG0534	Mate efflux family protein
V130003_13530	COG3001	Fructosamine kinase
V130003_13560	COG0840	transmembrane signaling receptor activity
V130003_13580	COG3148	PFAM DTW domain containing protein
V130003_13590	COG1940	carbohydrate kinase activity
V130003_13610	COG0303	'Molybdopterin
V130003_13620	COG0746	molybdenum cofactor guanylyltransferase activity
V130003_13630	COG3842	ATPase activity
V130003_13640	COG4662	Binding-protein-dependent transport system inner membrane component
V130003_13660	COG2204	response regulator
V130003_13670	COG3852	Histidine kinase
V130003_13680	COG0488	(ABC) transporter
V130003_13690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
V130003_13750	COG3383	formate dehydrogenase (NAD+) activity
V130003_13750	COG3383	formate dehydrogenase (NAD+) activity
V130003_13760	COG0437	4 iron, 4 sulfur cluster binding
V130003_13790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
V130003_13800	COG1666	GTP binding
V130003_13810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V130003_13840	COG2996	Protein conserved in bacteria
V130003_13860	COG3008	intermembrane lipid transfer
V130003_13870	COG2995	paraquat-inducible protein a
V130003_13880	COG1132	(ABC) transporter
V130003_13890	COG1956	GAF domain-containing protein
V130003_13900	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
V130003_13930	COG0308	aminopeptidase N
V130003_13950	COG0167	dihydroorotate dehydrogenase activity
V130003_13980	COG0116	Belongs to the methyltransferase superfamily
V130003_13980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V130003_14000	COG0488	(ABC) transporter
V130003_14030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V130003_14040	COG1067	ATP-dependent peptidase activity
V130003_14050	COG3120	sequence-specific DNA binding
V130003_14250	COG3064	Membrane
V130003_14250	COG1073	alpha beta
V130003_14250	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
V130003_14280	COG2994	toxin metabolic process
V130003_14330	COG0784	Response regulator, receiver
V130003_14330	COG2205	protein histidine kinase activity
V130003_14350	COG3278	Belongs to the heme-copper respiratory oxidase family
V130003_14380	COG2010	Cytochrome c
V130003_14400	COG2217	Heavy metal translocating P-type atpase
V130003_14430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
V130003_14440	COG0589	response to stress
V130003_14450	COG0037	tRNA processing
V130003_14490	COG3842	ATPase activity
V130003_14510	COG1177	transmembrane transport
V130003_14530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V130003_14560	COG1115	amino acid carrier protein
V130003_14570	COG1280	lysine exporter protein (LysE YggA)
V130003_14610	COG3501	Rhs element vgr protein
V130003_14630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
V130003_14640	COG0840	transmembrane signaling receptor activity
V130003_14650	COG2814	Major facilitator Superfamily
V130003_14660	COG1566	PFAM secretion protein HlyD family protein
V130003_14670	COG1538	Outer membrane efflux protein
V130003_14690	COG0513	Belongs to the DEAD box helicase family
V130003_14710	COG0840	transmembrane signaling receptor activity
V130003_14730	COG0415	Belongs to the DNA photolyase family
V130003_14740	COG0477	Major facilitator Superfamily
V130003_14750	COG0583	DNA-binding transcription factor activity
V130003_14760	COG0095	Lipoate-protein ligase
V130003_14770	COG0443	Heat shock 70 kDa protein
V130003_14780	COG0443	Heat shock 70 kDa protein
V130003_14820	COG1643	Atp-dependent helicase
V130003_14880	COG0443	Heat shock 70 kDa protein
V130003_14890	COG0443	Heat shock 70 kDa protein
V130003_14900	COG3706	GGDEF domain
V130003_14960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
V130003_14970	COG0602	queuosine metabolic process
V130003_14980	COG0561	phosphatase activity
V130003_15000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V130003_15010	COG4597	amino acid ABC transporter
V130003_15020	COG0765	amino acid transport
V130003_15030	COG1126	abc transporter atp-binding protein
V130003_15040	COG0670	Belongs to the BI1 family
V130003_15050	COG2920	part of a sulfur-relay system
V130003_15060	COG1254	Belongs to the acylphosphatase family
V130003_15070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V130003_15080	COG3706	GGDEF domain
V130003_15110	COG3437	response regulator, receiver
V130003_15120	COG0625	glutathione transferase activity
V130003_15140	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
V130003_15160	COG2195	Cleaves the N-terminal amino acid of tripeptides
V130003_15220	COG0372	Belongs to the citrate synthase family
V130003_15230	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
V130003_15310	COG1129	ABC transporter
V130003_15360	COG0745	RESPONSE REGULATOR receiver
V130003_15370	COG2205	protein histidine kinase activity
V130003_15380	COG3713	MltA-interacting MipA family protein
V130003_15390	COG2990	Protein conserved in bacteria
V130003_15410	COG2205	protein histidine kinase activity
V130003_15420	COG0471	metal ion transport
V130003_15440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V130003_15470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V130003_15490	COG3768	UPF0283 membrane protein
V130003_15500	COG3106	COG3106 Predicted ATPase
V130003_15530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
V130003_15540	COG0494	nUDIX hydrolase
V130003_15550	COG0814	amino acid
V130003_15560	COG1760	l-serine dehydratase
V130003_15570	COG1760	l-serine dehydratase
V130003_15580	COG0720	synthase
V130003_15590	COG0840	transmembrane signaling receptor activity
V130003_15600	COG0017	Asparaginyl-tRNA synthetase
V130003_15610	COG3385	transposase activity
V130003_15620	COG0351	phosphomethylpyrimidine kinase
V130003_15620	COG0352	thiamine-phosphate diphosphorylase activity
V130003_15630	COG2770	Histidine kinase
V130003_15630	COG3437	response regulator, receiver
V130003_15640	COG1448	Aminotransferase
V130003_15670	COG0840	transmembrane signaling receptor activity
V130003_15680	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
V130003_15690	COG2943	transferase activity, transferring hexosyl groups
V130003_15700	COG1609	Transcriptional regulator
V130003_15710	COG3394	polysaccharide catabolic process
V130003_15720	COG1486	melibiose metabolic process
V130003_15730	COG1447	Phosphotransferase system cellobiose-specific component IIA
V130003_15750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
V130003_15760	COG0726	polysaccharide deacetylase
V130003_15770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
V130003_15780	COG1846	Transcriptional regulator
V130003_15820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
V130003_15840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
V130003_15870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V130003_15880	COG3108	Peptidase M15
V130003_15940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
V130003_15960	COG2814	Major facilitator Superfamily
V130003_15980	COG1054	Belongs to the UPF0176 family
V130003_16000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V130003_16010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V130003_16020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V130003_16110	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
V130003_16120	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
V130003_16130	COG4139	cobalamin transport
V130003_16140	COG2988	succinylglutamate desuccinylase activity
V130003_16170	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
V130003_16180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
V130003_16190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V130003_16200	COG1823	symporter activity
V130003_16210	COG2925	Exonuclease
V130003_16220	COG1380	Effector of murein hydrolase LrgA
V130003_16230	COG1346	cytolysis
V130003_16290	COG0776	regulation of translation
V130003_16300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V130003_16300	COG0072	phenylalanine-tRNA ligase activity
V130003_16310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
V130003_16350	COG0322	excinuclease ABC activity
V130003_16360	COG2197	response regulator
V130003_16370	COG0417	DNA replication proofreading
V130003_16380	COG5001	Diguanylate cyclase
V130003_16400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
V130003_16410	COG3099	Belongs to the UPF0263 family
V130003_16450	COG1228	amidohydrolase
V130003_16460	COG0010	Belongs to the arginase family
V130003_16470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
V130003_16480	COG2986	histidine ammonia-lyase
V130003_16520	COG0247	lactate metabolic process
V130003_16520	COG0277	FAD linked oxidase domain protein
V130003_16560	COG2885	chlorophyll binding
V130003_16600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
V130003_16620	COG0281	malic enzyme
V130003_16640	COG2949	membrane
V130003_16650	COG3706	GGDEF domain
V130003_16660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V130003_16680	COG0492	ferredoxin-NADP+ reductase activity
V130003_16690	COG4988	ABC transporter
V130003_16700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
V130003_16710	COG1187	pseudouridine synthase activity
V130003_16720	COG0009	L-threonylcarbamoyladenylate synthase
V130003_16730	COG0613	PHP domain protein
V130003_16740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
V130003_16750	COG0512	Glutamine amidotransferase of anthranilate synthase
V130003_16760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
V130003_16770	COG0134	indole-3-glycerol-phosphate synthase activity
V130003_16770	COG0135	phosphoribosylanthranilate isomerase activity
V130003_16780	COG0133	tryptophan synthase activity
V130003_16790	COG0159	tryptophan synthase activity
V130003_16810	COG1435	thymidine kinase activity
V130003_16820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
V130003_16830	COG1801	Protein of unknown function DUF72
V130003_16840	COG4106	trans-aconitate 2-methyltransferase activity
V130003_16850	COG0500	methyltransferase
V130003_16860	COG0189	ligase activity
V130003_16860	COG4067	protein conserved in archaea
V130003_16890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
V130003_16910	COG3852	Histidine kinase
V130003_16940	COG3070	regulator of competence-specific genes
V130003_16960	COG2431	L-lysine efflux transmembrane transporter activity
V130003_16980	COG0076	glutamate decarboxylase activity
V130003_16990	COG1737	Transcriptional regulator
V130003_17000	COG1454	alcohol dehydrogenase
V130003_17000	COG1012	belongs to the aldehyde dehydrogenase family
V130003_17010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
V130003_17020	COG3273	potassium ion transport
V130003_17020	COG2985	domain, Protein
V130003_17030	COG0542	response to heat
V130003_17040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
V130003_17050	COG1278	Cold shock
V130003_17070	COG1187	pseudouridine synthase activity
V130003_17080	COG0140	phosphoribosyl-ATP diphosphatase activity
V130003_17080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
V130003_17090	COG0107	imidazoleglycerol-phosphate synthase activity
V130003_17100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
V130003_17110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
V130003_17120	COG0131	Imidazoleglycerol-phosphate dehydratase
V130003_17120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V130003_17130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
V130003_17140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
V130003_17150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
V130003_17160	COG1757	Na H antiporter
V130003_17170	COG2916	Histone family protein nucleoid-structuring protein H-NS
V130003_17180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V130003_17190	COG0482	sulfurtransferase activity
V130003_17200	COG2915	High frequency lysogenization protein hflD homolog
V130003_17210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
V130003_17230	COG2268	Band 7 protein
V130003_17250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
V130003_17280	COG0300	oxidoreductase activity
V130003_17300	COG0501	Belongs to the peptidase M48B family
V130003_17320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
V130003_17330	COG2226	methyltransferase
V130003_17340	COG0156	8-amino-7-oxononanoate synthase activity
V130003_17350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V130003_17360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
V130003_17370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
V130003_17380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
V130003_17390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
V130003_17400	COG0653	protein targeting
V130003_17410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V130003_17420	COG2199	diguanylate cyclase activity
V130003_17420	COG2203	Gaf domain
V130003_17440	COG4120	Belongs to the binding-protein-dependent transport system permease family
V130003_17460	COG4628	conserved protein (DUF2132)
V130003_17470	COG3092	negative regulation of chromosome organization
V130003_17480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
V130003_17490	COG0857	belongs to the CobB CobQ family
V130003_17490	COG0280	phosphate acetyltransferase
V130003_17500	COG0435	Glutathione S-transferase
V130003_17510	COG4608	Belongs to the ABC transporter superfamily
V130003_17520	COG0444	Belongs to the ABC transporter superfamily
V130003_17530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V130003_17540	COG0601	transmembrane transport
V130003_17580	COG2204	response regulator
V130003_17590	COG3300	MHYT domain
V130003_17590	COG5001	Diguanylate cyclase
V130003_17600	COG2204	response regulator
V130003_17610	COG4191	Histidine kinase
V130003_17620	COG5002	protein histidine kinase activity
V130003_17640	COG2201	protein-glutamate methylesterase activity
V130003_17670	COG0009	L-threonylcarbamoyladenylate synthase
V130003_17700	COG1881	PFAM PEBP family protein
V130003_17750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V130003_17760	COG0640	Transcriptional regulator
V130003_17770	COG3706	GGDEF domain
V130003_17810	COG1946	Acyl-CoA thioesterase
V130003_17820	COG1522	sequence-specific DNA binding
V130003_17840	COG0616	signal peptide processing
V130003_17850	COG1028	Short-chain dehydrogenase reductase Sdr
V130003_17860	COG2983	Belongs to the UPF0260 family
V130003_17880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
V130003_17890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
V130003_17900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
V130003_17910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
V130003_17950	COG0745	RESPONSE REGULATOR receiver
V130003_17960	COG0583	DNA-binding transcription factor activity
V130003_17970	COG0778	Nitroreductase
V130003_17980	COG1250	3-hydroxyacyl-CoA dehydrogenase
V130003_17980	COG1024	Enoyl-CoA hydratase
V130003_17990	COG0183	Belongs to the thiolase family
V130003_18020	COG2067	long-chain fatty acid transport protein
V130003_18040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
V130003_18050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
V130003_18060	COG2982	Protein involved in outer membrane biogenesis
V130003_18070	COG0572	uridine kinase
V130003_18090	COG0489	protein tyrosine kinase activity
V130003_18100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V130003_18100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V130003_18120	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
V130003_18140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
V130003_18140	COG0617	tRNA 3'-terminal CCA addition
V130003_18140	COG0517	IMP dehydrogenase activity
V130003_18150	COG2199	diguanylate cyclase activity
V130003_18160	COG0314	molybdopterin synthase activity
V130003_18170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
V130003_18180	COG0315	cyclic pyranopterin monophosphate synthase activity
V130003_18190	COG0521	Mo-molybdopterin cofactor biosynthetic process
V130003_18200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
V130003_18210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
V130003_18220	COG2198	Histidine kinase
V130003_18230	COG2204	response regulator
V130003_18240	COG0556	nucleotide-excision repair
V130003_18250	COG0556	nucleotide-excision repair
V130003_18260	COG4657	Part of a membrane complex involved in electron transport
V130003_18270	COG2878	Part of a membrane complex involved in electron transport
V130003_18280	COG4656	Part of a membrane complex involved in electron transport
V130003_18310	COG4660	Part of a membrane complex involved in electron transport
V130003_18320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
V130003_18330	COG0346	lactoylglutathione lyase activity
V130003_18360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
V130003_18370	COG2056	Na+-H+ antiporter family
V130003_18380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
V130003_18390	COG1286	toxin biosynthetic process
V130003_18400	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
V130003_18410	COG0285	dihydrofolate synthase activity
V130003_18420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
V130003_18430	COG0101	tRNA pseudouridine synthase activity
V130003_18470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V130003_18470	COG2190	(PTS) system
V130003_18470	COG1263	PTS System
V130003_18480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V130003_18490	COG1846	Transcriptional regulator
V130003_18490	COG1940	carbohydrate kinase activity
V130003_18500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V130003_18500	COG4651	solute:proton antiporter activity
V130003_18510	COG0367	asparagine synthase
V130003_18520	COG0367	asparagine synthase
V130003_18550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
V130003_18560	COG0563	adenylate kinase activity
V130003_18570	COG0326	Molecular chaperone. Has ATPase activity
V130003_18580	COG3710	Transcriptional regulator
V130003_18610	COG0622	Phosphoesterase
V130003_18620	COG1090	epimerase
V130003_18630	COG0300	oxidoreductase activity
V130003_18640	COG3118	belongs to the thioredoxin family
V130003_18650	COG0330	HflC and HflK could
V130003_18660	COG1585	Membrane protein implicated in regulation of membrane protease activity
V130003_18670	COG0789	Transcriptional regulator
V130003_18680	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V130003_18700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
V130003_18710	COG3115	cell septum assembly
V130003_18720	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
V130003_18730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
V130003_18740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V130003_18760	COG2190	(PTS) system
V130003_18770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V130003_18780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V130003_18790	COG1702	phosphate starvation-inducible protein PhoH
V130003_18800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
V130003_18810	COG4535	Mg2 and Co2 transporter CorC
V130003_18820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
V130003_18830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
V130003_18840	COG2888	peptidyl-tyrosine sulfation
V130003_18850	COG0495	leucyl-tRNA aminoacylation
V130003_18860	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
V130003_18870	COG1466	dna polymerase III delta subunit
V130003_18880	COG0799	negative regulation of ribosome biogenesis
V130003_18890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
V130003_18900	COG0768	penicillin binding
V130003_18910	COG0772	Belongs to the SEDS family
V130003_18920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
V130003_18930	COG1686	Belongs to the peptidase S11 family
V130003_18940	COG2921	Belongs to the UPF0250 family
V130003_18950	COG0321	lipoyl(octanoyl) transferase activity
V130003_18960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
V130003_18980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
V130003_19030	COG1596	polysaccharide export
V130003_19050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
V130003_19110	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
V130003_19130	COG0438	transferase activity, transferring glycosyl groups
V130003_19180	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
V130003_19190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
V130003_19200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
V130003_19210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V130003_19230	COG0366	Alpha amylase catalytic
V130003_19240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V130003_19240	COG1263	PTS System
V130003_19250	COG1609	Transcriptional regulator
V130003_19260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V130003_19270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
V130003_19280	COG2011	ABC-type metal ion transport system permease component
V130003_19290	COG1464	Belongs to the NlpA lipoprotein family
V130003_19300	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
V130003_19320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V130003_19320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V130003_19350	COG1611	Belongs to the LOG family
V130003_19360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V130003_19380	COG0583	DNA-binding transcription factor activity
V130003_19390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V130003_19390	COG0301	tRNA thio-modification
V130003_19410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
V130003_19420	COG1722	exodeoxyribonuclease VII activity
V130003_19430	COG0142	geranyltranstransferase activity
V130003_19440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
V130003_19450	COG0564	pseudouridine synthase activity
V130003_19460	COG3098	single-species biofilm formation
V130003_19490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V130003_19510	COG1671	Belongs to the UPF0178 family
V130003_19520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
V130003_19530	COG0254	rRNA binding
V130003_19540	COG1720	tRNA m6t6A37 methyltransferase activity
V130003_19550	COG0442	prolyl-tRNA aminoacylation
V130003_19590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
V130003_19590	COG0047	phosphoribosylformylglycinamidine synthase activity
V130003_19610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
V130003_19630	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
V130003_19690	COG0484	heat shock protein binding
V130003_19700	COG0484	heat shock protein binding
V130003_19710	COG0443	Heat shock 70 kDa protein
V130003_19720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
V130003_19730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
V130003_19740	COG0497	DNA recombination
V130003_19750	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V130003_19760	COG2914	Belongs to the UPF0125 (RnfH) family
V130003_19770	COG2867	negative regulation of translational initiation
V130003_19780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
V130003_19790	COG0582	viral genome integration into host DNA
V130003_19820	COG5433	transposase activity
V130003_19830	COG2801	Transposase and inactivated derivatives
V130003_19920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
V130003_19980	COG1766	The M ring may be actively involved in energy transduction
V130003_19990	COG1677	Flagellar hook-basal body complex protein FliE
V130003_20020	COG1706	bacterial-type flagellum-dependent cell motility
V130003_20030	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
V130003_20050	COG4786	Flagellar basal body rod
V130003_20060	COG4786	Flagellar basal body rod
V130003_20070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
V130003_20080	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
V130003_20090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
V130003_20100	COG4791	protein targeting
V130003_20200	COG2003	Belongs to the UPF0758 family
V130003_20310	COG1061	Type III restriction enzyme res subunit
V130003_20320	COG3335	DDE superfamily endonuclease
V130003_20350	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
V130003_20360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
V130003_20370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
V130003_20410	COG3051	citrate lyase alpha subunit
V130003_20420	COG2301	Belongs to the HpcH HpaI aldolase family
V130003_20430	COG3052	prosthetic group binding
V130003_20440	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
V130003_20460	COG3630	sodium ion export across plasma membrane
V130003_20470	COG0511	ligase activity, forming carbon-carbon bonds
V130003_20470	COG5016	pyruvate
V130003_20480	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
V130003_20500	COG4565	transcriptional regulatory protein
V130003_20530	COG0583	DNA-binding transcription factor activity
V130003_20550	COG1115	amino acid carrier protein
V130003_20570	COG1120	ATPase activity
V130003_20580	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V130003_20590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V130003_20600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V130003_20610	COG4592	Periplasmic binding protein
V130003_20630	COG1028	Short-chain dehydrogenase reductase Sdr
V130003_20640	COG1169	isochorismate synthase
V130003_20650	COG1021	2,3-dihydroxybenzoate-AMP ligase
V130003_20660	COG1535	isochorismatase
V130003_20660	COG3433	isochorismatase activity
V130003_20670	COG1584	GPR1 FUN34 yaaH family protein
V130003_20900	COG3335	DDE superfamily endonuclease
V130003_20950	COG0582	viral genome integration into host DNA
V130003_20960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
V130003_20960	COG0519	Catalyzes the synthesis of GMP from XMP
V130003_20970	COG0516	GMP reductase activity
V130003_20970	COG0517	IMP dehydrogenase activity
V130003_20980	COG1570	exodeoxyribonuclease VII activity
V130003_21010	COG1160	GTP binding
V130003_21020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V130003_21030	COG2976	Protein conserved in bacteria
V130003_21040	COG0124	histidyl-tRNA synthetase
V130003_21050	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
V130003_21080	COG0105	UTP biosynthetic process
V130003_21090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V130003_21100	COG2975	iron-sulfur cluster assembly
V130003_21110	COG0633	Ferredoxin
V130003_21150	COG0822	iron-sulfur transferase activity
V130003_21170	COG1959	2 iron, 2 sulfur cluster binding
V130003_21190	COG0483	inositol monophosphate 1-phosphatase activity
V130003_21200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V130003_21210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V130003_21220	COG1862	Preprotein translocase
V130003_21240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
V130003_21250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
V130003_21260	COG0517	IMP dehydrogenase activity
V130003_21280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
V130003_21290	COG0583	DNA-binding transcription factor activity
V130003_21300	COG0450	alkyl hydroperoxide reductase
V130003_21310	COG3142	Participates in the control of copper homeostasis
V130003_21340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
V130003_21350	COG0581	inorganic phosphate transmembrane transporter activity
V130003_21370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
V130003_21380	COG0248	Ppx GppA phosphatase
V130003_21400	COG5002	protein histidine kinase activity
V130003_21410	COG0745	RESPONSE REGULATOR receiver
V130003_21430	COG0826	peptidase U32
V130003_21440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V130003_21470	COG0542	response to heat
V130003_21480	COG0542	response to heat
V130003_21490	COG1496	oxidoreductase activity
V130003_21500	COG0564	pseudouridine synthase activity
V130003_21510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V130003_21520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
V130003_21530	COG0077	Prephenate dehydratase
V130003_21530	COG1605	Chorismate mutase
V130003_21540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V130003_21550	COG5001	Diguanylate cyclase
V130003_21570	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
V130003_21590	COG0488	(ABC) transporter
V130003_21610	COG1605	Chorismate mutase
V130003_21610	COG0287	Prephenate dehydrogenase
V130003_21620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V130003_21630	COG3275	phosphorelay sensor kinase activity
V130003_21640	COG3279	Response regulator of the LytR AlgR family
V130003_21660	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
V130003_21670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
V130003_21690	COG1966	Carbon starvation protein
V130003_21700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
V130003_21710	COG1047	Peptidyl-prolyl cis-trans
V130003_21720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
V130003_21740	COG0196	riboflavin kinase activity
V130003_21750	COG0728	peptidoglycan biosynthetic process
V130003_21760	COG0728	peptidoglycan biosynthetic process
V130003_21770	COG0268	Binds directly to 16S ribosomal RNA
V130003_21780	COG0640	Transcriptional regulator
V130003_21790	COG0583	DNA-binding transcription factor activity
V130003_21800	COG1283	sodium-dependent phosphate transmembrane transporter activity
V130003_21820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
V130003_21830	COG0730	response to heat
V130003_21840	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
V130003_21850	COG0494	nUDIX hydrolase
V130003_21870	COG0667	Aldo Keto reductase
V130003_21890	COG2204	response regulator
V130003_21900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
V130003_21910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
V130003_21940	COG0513	Belongs to the DEAD box helicase family
V130003_21990	COG3153	acetyltransferase
V130003_22000	COG3154	lipid carrier protein
V130003_22020	COG0826	peptidase U32
V130003_22030	COG0826	peptidase U32
V130003_22080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
V130003_22100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
V130003_22110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
V130003_22120	COG0195	Participates in both transcription termination and antitermination
V130003_22130	COG0779	Required for maturation of 30S ribosomal subunits
V130003_22140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V130003_22160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
V130003_22170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
V130003_22180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
V130003_22190	COG1534	Rna-binding protein
V130003_22200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V130003_22220	COG2027	D-alanyl-D-alanine carboxypeptidase
V130003_22230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V130003_22240	COG0739	heme binding
V130003_22270	COG0316	Belongs to the HesB IscA family
V130003_22280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
V130003_22290	COG0628	permease
V130003_22300	COG2813	Specifically methylates the guanine in position
V130003_22340	COG2801	Transposase and inactivated derivatives
V130003_22350	COG0747	negative chemotaxis
V130003_22360	COG0601	transmembrane transport
V130003_22370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V130003_22380	COG0444	Belongs to the ABC transporter superfamily
V130003_22390	COG4608	Belongs to the ABC transporter superfamily
V130003_22410	COG2971	BadF BadG BcrA BcrD
V130003_22450	COG3842	ATPase activity
V130003_22470	COG1840	ABC-type Fe3 transport system, periplasmic component
V130003_22480	COG0004	ammonium transporteR
V130003_22490	COG0347	Belongs to the P(II) protein family
V130003_22500	COG3112	Uncharacterised protein family (UPF0231)
V130003_22510	COG1049	propionate catabolic process, 2-methylcitrate cycle
V130003_22520	COG1752	Esterase of the alpha-beta hydrolase superfamily
V130003_22530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
V130003_22540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
V130003_22550	COG1643	Atp-dependent helicase
V130003_22570	COG1489	DNA binding
V130003_22590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V130003_22610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
V130003_22620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
V130003_22630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
V130003_22640	COG0842	Transport permease protein
V130003_22650	COG1131	(ABC) transporter
V130003_22660	COG0659	secondary active sulfate transmembrane transporter activity
V130003_22670	COG0288	reversible hydration of carbon dioxide
V130003_22700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
V130003_22710	COG3107	peptidoglycan biosynthetic process
V130003_22720	COG0792	nuclease activity
V130003_22730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V130003_22740	COG2823	Periplasmic or secreted lipoprotein
V130003_22750	COG2969	positive regulation of protein catabolic process
V130003_22760	COG0625	glutathione transferase activity
V130003_22770	COG2857	Cytochrome c1
V130003_22780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
V130003_22790	COG0723	plastoquinol--plastocyanin reductase activity
V130003_22800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
V130003_22810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
V130003_22820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
V130003_22840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V130003_22850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V130003_22860	COG0335	large ribosomal subunit rRNA binding
V130003_22870	COG0336	Belongs to the RNA methyltransferase TrmD family
V130003_22880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
V130003_22890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
V130003_22900	COG0228	four-way junction DNA binding
V130003_22910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
V130003_22920	COG4137	Cytochrome C assembly protein
V130003_22930	COG4536	flavin adenine dinucleotide binding
V130003_22940	COG1854	S-ribosylhomocysteine lyase activity
V130003_22950	COG2918	glutathione biosynthetic process
V130003_22960	COG0612	Peptidase, M16
V130003_22970	COG1238	metal cluster binding
V130003_22990	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
V130003_23000	COG0511	ligase activity, forming carbon-carbon bonds
V130003_23000	COG5016	pyruvate
V130003_23010	COG3630	sodium ion export across plasma membrane
V130003_23020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
V130003_23030	COG0527	aspartate kinase activity
V130003_23040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
V130003_23050	COG2137	regulation of response to DNA damage stimulus
V130003_23060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
V130003_23080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
V130003_23090	COG4208	sulfate ABC transporter
V130003_23130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
V130003_23140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V130003_23160	COG1388	LysM domain
V130003_23160	COG4942	peptidase
V130003_23170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
V130003_23180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
V130003_23190	COG0585	pseudouridine synthase activity
V130003_23200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
V130003_23210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
V130003_23220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
V130003_23230	COG1968	undecaprenyl-diphosphatase activity
V130003_23240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
V130003_23250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
V130003_23260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
V130003_23280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
V130003_23290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
V130003_23300	COG1610	YqeY-like protein
V130003_23310	COG0358	DNA primase activity
V130003_23330	COG0582	viral genome integration into host DNA
V130003_23380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
V130003_23440	COG0840	transmembrane signaling receptor activity
V130003_23470	COG3547	Transposase (IS116 IS110 IS902 family)
V130003_23480	COG2801	Transposase and inactivated derivatives
V130003_23490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
V130003_23500	COG1349	DNA-binding transcription factor activity
V130003_23540	COG1279	arginine transmembrane transporter activity
V130003_23550	COG0668	transmembrane transport
V130003_23560	COG0191	fructose-bisphosphate aldolase activity
V130003_23570	COG0126	phosphoglycerate kinase activity
V130003_23580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V130003_23590	COG4771	TonB-dependent receptor
V130003_23600	COG0583	DNA-binding transcription factor activity
V130003_23610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
V130003_23620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
V130003_23630	COG3091	SprT-like family
V130003_23640	COG2356	endonuclease I
V130003_23650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
V130003_23660	COG0189	ligase activity
V130003_23670	COG1678	Uncharacterized ACR, COG1678
V130003_23680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
V130003_23690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V130003_23730	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
V130003_23740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
V130003_23750	COG0762	integral membrane protein
V130003_23760	COG1872	DUF167
V130003_23780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
V130003_23790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
V130003_23800	COG2066	Belongs to the glutaminase family
V130003_23810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
V130003_23820	COG1194	a g-specific adenine glycosylase
V130003_23830	COG1194	a g-specific adenine glycosylase
V130003_23840	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
V130003_23850	COG0741	lytic transglycosylase activity
V130003_23860	COG0840	transmembrane signaling receptor activity
V130003_23870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
V130003_23880	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
V130003_23890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V130003_23900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
V130003_23910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
V130003_23920	COG2967	ApaG domain
V130003_23930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
V130003_23950	COG3610	response to peptide
V130003_23960	COG2966	Psort location CytoplasmicMembrane, score
V130003_23970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
V130003_23980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
V130003_23990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
V130003_24000	COG0142	geranyltranstransferase activity
V130003_24010	COG0531	amino acid
V130003_24020	COG0039	L-malate dehydrogenase activity
V130003_24030	COG1438	arginine binding
V130003_24040	COG2358	TRAP transporter, solute receptor (TAXI family
V130003_24060	COG0589	response to stress
V130003_24100	COG2235	arginine
V130003_24110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V130003_24120	COG1151	hydroxylamine reductase activity
V130003_24130	COG1151	hydroxylamine reductase activity
V130003_24140	COG0312	modulator of DNA gyrase
V130003_24150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
V130003_24160	COG3164	Protein of unknown function
V130003_24180	COG0424	maF-like protein
V130003_24190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
V130003_24200	COG1792	Involved in formation and maintenance of cell shape
V130003_24210	COG1077	Cell shape determining protein MreB Mrl
V130003_24280	COG2165	general secretion pathway protein
V130003_24290	COG2165	general secretion pathway protein
V130003_24310	COG1459	type II secretion system
V130003_24320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V130003_24340	COG3267	Type II secretory pathway component ExeA
V130003_24340	COG3409	Peptidoglycan-binding domain 1 protein
V130003_24390	COG2199	diguanylate cyclase activity
V130003_24390	COG2200	EAL domain
V130003_24400	COG0629	single-stranded DNA binding
V130003_24430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
V130003_24450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
V130003_24460	COG0527	aspartate kinase activity
V130003_24470	COG0646	methionine synthase
V130003_24470	COG1410	methionine synthase
V130003_24490	COG0175	sulfate reduction
V130003_24510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V130003_24550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V130003_24560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V130003_24570	COG0735	belongs to the Fur family
V130003_24600	COG0166	Belongs to the GPI family
V130003_24610	COG0432	Pfam Uncharacterised protein family UPF0047
V130003_24620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V130003_24650	COG0359	binds to the 23S rRNA
V130003_24660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
V130003_24670	COG0360	Binds together with S18 to 16S ribosomal RNA
V130003_24690	COG2906	2 iron, 2 sulfur cluster binding
V130003_24700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V130003_24710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
V130003_24720	COG0049	tRNA binding
V130003_24750	COG2923	Belongs to the DsrF TusC family
V130003_24760	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
V130003_24770	COG2964	Protein conserved in bacteria
V130003_24780	COG0545	Peptidyl-prolyl cis-trans isomerase
V130003_24800	COG2900	Belongs to the SlyX family
V130003_24810	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
V130003_24820	COG0330	HflC and HflK could
V130003_24830	COG0330	HflC and HflK could
V130003_24840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
V130003_24850	COG1923	regulation of RNA biosynthetic process
V130003_24860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
V130003_24870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
V130003_24890	COG0802	atpase or kinase
V130003_24900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
V130003_24910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
V130003_24920	COG1162	GTPase activity
V130003_24930	COG0688	phosphatidylethanolamine metabolic process
V130003_24940	COG0471	metal ion transport
V130003_24960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
V130003_24970	COG4942	peptidase
V130003_25000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
V130003_25010	COG2816	NAD+ diphosphatase activity
V130003_25020	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
V130003_25030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
V130003_25040	COG0085	RNA polymerase activity
V130003_25050	COG0222	ribosome binding
V130003_25060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
V130003_25080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
V130003_25090	COG0250	Participates in transcription elongation, termination and antitermination
V130003_25100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V130003_25110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V130003_25120	COG1072	(Pantothenic acid kinase))
V130003_25140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
V130003_25160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
V130003_25190	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
V130003_25230	COG3118	belongs to the thioredoxin family
V130003_25240	COG0513	Belongs to the DEAD box helicase family
V130003_25250	COG0248	Ppx GppA phosphatase
V130003_25260	COG0784	Response regulator, receiver
V130003_25260	COG2205	protein histidine kinase activity
V130003_25270	COG2814	Major facilitator Superfamily
V130003_25300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V130003_25310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
V130003_25320	COG0511	ligase activity, forming carbon-carbon bonds
V130003_25330	COG0439	Biotin carboxylase
V130003_25340	COG2264	protein methyltransferase activity
V130003_25350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V130003_25360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
V130003_25370	COG1609	Transcriptional regulator
V130003_25380	COG0129	dihydroxy-acid dehydratase activity
V130003_25390	COG0129	dihydroxy-acid dehydratase activity
V130003_25400	COG3265	gluconokinase activity
V130003_25410	COG2610	gluconate transmembrane transporter activity
V130003_25420	COG0800	Aldolase
V130003_25450	COG0840	transmembrane signaling receptor activity
V130003_25460	COG1982	Orn Lys Arg decarboxylase major
V130003_25470	COG0531	amino acid
V130003_25480	COG3710	Transcriptional regulator
V130003_25490	COG0789	Transcriptional regulator
V130003_25510	COG0151	Belongs to the GarS family
V130003_25530	COG0776	regulation of translation
V130003_25540	COG1253	flavin adenine dinucleotide binding
V130003_25550	COG3068	Protein conserved in bacteria
V130003_25570	COG1573	uracil-dna glycosylase
V130003_25580	COG0668	transmembrane transport
V130003_25610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
V130003_25630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
V130003_25640	COG1215	transferase activity, transferring glycosyl groups
V130003_25740	COG1596	polysaccharide export
V130003_25780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V130003_25800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
V130003_25850	COG0438	transferase activity, transferring glycosyl groups
V130003_25930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
V130003_25970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V130003_26020	COG0859	PFAM glycosyl transferase family 9
V130003_26040	COG1519	Transferase
V130003_26100	COG2755	lipolytic protein G-D-S-L family
V130003_26100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
V130003_26110	COG3642	lipopolysaccharide core region biosynthetic process
V130003_26120	COG0859	PFAM glycosyl transferase family 9
V130003_26130	COG0463	Glycosyl transferase, family 2
V130003_26140	COG0859	PFAM glycosyl transferase family 9
V130003_26150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
V130003_26160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
V130003_26180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
V130003_26190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
V130003_26200	COG2003	Belongs to the UPF0758 family
V130003_26220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
V130003_26230	COG1309	transcriptional regulator
V130003_26240	COG1560	Kdo2-lipid A biosynthetic process
V130003_26250	COG1560	Kdo2-lipid A biosynthetic process
V130003_26260	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
V130003_26270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
V130003_26280	COG1561	YicC-like family, N-terminal region
V130003_26360	COG2003	Belongs to the UPF0758 family
V130003_26410	COG0446	pyridine nucleotide-disulphide oxidoreductase
V130003_26450	COG0450	alkyl hydroperoxide reductase
V130003_26460	COG0328	RNA-DNA hybrid ribonuclease activity
V130003_26520	COG2862	Uncharacterized protein family, UPF0114
V130003_26530	COG3385	transposase activity
V130003_26540	COG1263	PTS System
V130003_26540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V130003_26550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
V130003_26590	COG1120	ATPase activity
V130003_26600	COG4774	siderophore transport
V130003_26610	COG1132	(ABC) transporter
V130003_26640	COG0514	ATP-dependent DNA helicase (RecQ)
V130003_26650	COG0514	ATP-dependent DNA helicase (RecQ)
V130003_26660	COG2962	Rard protein
V130003_26670	COG0405	Gamma-glutamyltransferase
V130003_26690	COG1280	lysine exporter protein (LysE YggA)
V130003_26700	COG0210	DNA helicase
V130003_26720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
V130003_26730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V130003_26750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V130003_26760	COG0601	transmembrane transport
V130003_26770	COG0747	negative chemotaxis
V130003_26820	COG1309	transcriptional regulator
V130003_26830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V130003_26840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V130003_26850	COG2960	long-chain fatty acid transporting porin activity
V130003_26860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
V130003_26870	COG0583	DNA-binding transcription factor activity
V130003_26890	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
V130003_26900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V130003_26910	COG1739	Uncharacterized protein family UPF0029
V130003_26920	COG1024	Enoyl-CoA hydratase
V130003_26920	COG1250	3-hydroxyacyl-CoA dehydrogenase
V130003_26930	COG0183	Belongs to the thiolase family
V130003_26940	COG0583	DNA-binding transcription factor activity
V130003_26950	COG2814	Major facilitator Superfamily
V130003_26960	COG3385	transposase activity
V130003_26980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
V130003_26990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
V130003_27000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
V130003_27010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
V130003_27020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
V130003_27030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
V130003_27050	COG0356	it plays a direct role in the translocation of protons across the membrane
V130003_27060	COG3312	ion transport
V130003_27070	COG1475	DNA binding
V130003_27080	COG1192	Involved in chromosome partitioning
V130003_27090	COG0357	Ribosomal RNA small subunit methyltransferase G
V130003_27100	COG0445	tRNA wobble uridine modification
V130003_27110	COG0445	tRNA wobble uridine modification
V130003_27120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V130003_27190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
V130003_27280	COG4974	Belongs to the 'phage' integrase family
V130003_27290	COG3385	transposase activity
V130003_27310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
V130003_27320	COG0706	membrane insertase activity
V130003_27330	COG0594	ribonuclease P activity
V130003_27340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
V130003_27350	COG1126	abc transporter atp-binding protein
V130003_27420	COG0217	transcriptional regulatory protein
V130003_27430	COG2084	Dehydrogenase
V130003_27460	COG2909	trisaccharide binding
V130003_27470	COG0058	SHG alpha-glucan phosphorylase activity
V130003_27480	COG1640	4-alpha-glucanotransferase
V130003_27490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
V130003_27520	COG3501	Rhs element vgr protein
V130003_27600	COG0471	metal ion transport
V130003_27610	COG0471	metal ion transport
V130003_27630	COG3385	transposase activity
V130003_27640	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V130003_27720	COG0671	phosphoesterase, PA-phosphatase related
V130003_27730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
V130003_27750	COG1999	signal sequence binding
V130003_27780	COG0786	glutamate:sodium symporter activity
V130003_27850	COG0813	purine-nucleoside phosphorylase activity
V130003_27860	COG3272	Protein of unknown function (DUF1722)
V130003_27880	COG0415	Belongs to the DNA photolyase family
V130003_27890	COG0415	Belongs to the DNA photolyase family
V130003_27900	COG1388	LysM domain
V130003_27900	COG1376	ErfK ybiS ycfS ynhG family protein
V130003_27920	COG0513	Belongs to the DEAD box helicase family
V130003_27930	COG1770	oligopeptidase
V130003_27980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
V130003_27990	COG0573	inorganic phosphate transmembrane transporter activity
V130003_28000	COG0581	inorganic phosphate transmembrane transporter activity
V130003_28010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
V130003_28040	COG3314	Sporulation integral membrane protein YlbJ
V130003_28050	COG0659	secondary active sulfate transmembrane transporter activity
V130003_28070	COG0739	heme binding
V130003_28080	COG5001	Diguanylate cyclase
V130003_28080	COG3300	MHYT domain
V130003_28090	COG0583	DNA-binding transcription factor activity
V130003_28100	COG2814	Major facilitator Superfamily
V130003_28150	COG1301	dicarboxylic acid transport
V130003_28170	COG1342	Belongs to the UPF0251 family
V130003_28230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
V130003_28240	COG0673	inositol 2-dehydrogenase activity
V130003_28260	COG2771	luxR family
V130003_28260	COG2200	EAL domain
V130003_28270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V130003_28290	COG0564	pseudouridine synthase activity
V130003_28420	COG3829	transcription factor binding
V130003_28490	COG3409	Peptidoglycan-binding domain 1 protein
V130003_28490	COG3501	Rhs element vgr protein
V130003_28530	COG1869	D-ribose catabolic process
V130003_28540	COG1129	ABC transporter
V130003_28550	COG1172	Belongs to the binding-protein-dependent transport system permease family
V130003_28560	COG1879	ABC-type sugar transport system periplasmic component
V130003_28570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V130003_28580	COG1609	Transcriptional regulator
V130003_28610	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
V130003_28630	COG0584	glycerophosphoryl diester phosphodiesterase
V130003_28640	COG2271	Major facilitator Superfamily
V130003_28710	COG0579	oxidoreductase
V130003_28730	COG0242	peptide deformylase activity
V130003_28760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V130003_28770	COG1609	Transcriptional regulator
V130003_28780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V130003_28780	COG1017	nitric oxide dioxygenase activity
V130003_28790	COG1320	monovalent cation:proton antiporter activity
V130003_28800	COG2212	antiporter activity
V130003_28810	COG1863	multisubunit Na H antiporter MnhE subunit
V130003_28820	COG0651	ATP synthesis coupled electron transport
V130003_28830	COG1006	Multisubunit Na H antiporter MnhC subunit
V130003_28840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
V130003_28840	COG2111	Na H antiporter
V130003_28860	COG0589	response to stress
V130003_28870	COG0814	amino acid
V130003_28890	COG3530	Putative quorum-sensing-regulated virulence factor
V130003_28910	COG5001	Diguanylate cyclase
V130003_28910	COG5002	protein histidine kinase activity
V130003_28920	COG1278	Cold shock
V130003_28950	COG2304	oxidoreductase activity
V130003_28990	COG0714	Associated with various cellular activities
V130003_29010	COG0840	transmembrane signaling receptor activity
V130003_29040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V130003_29050	COG2195	Cleaves the N-terminal amino acid of tripeptides
V130003_29070	COG3604	Transcriptional regulator
V130003_29080	COG1017	nitric oxide dioxygenase activity
V130003_29080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V130003_29090	COG1278	Cold shock
V130003_29100	COG3036	rescue of stalled ribosome
V130003_29150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
V130003_29150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
V130003_29160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V130003_29180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V130003_29200	COG0516	GMP reductase activity
V130003_29220	COG0513	Belongs to the DEAD box helicase family
V130003_29230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V130003_29240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
V130003_29250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
V130003_29260	COG0784	Response regulator, receiver
V130003_29260	COG3437	response regulator, receiver
V130003_29270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V130003_29270	COG4191	Histidine kinase
V130003_29290	COG1757	Na H antiporter
V130003_29300	COG2814	Major facilitator Superfamily
V130003_29310	COG3706	GGDEF domain
V130003_29320	COG3240	lipase activity
V130003_29340	COG0840	transmembrane signaling receptor activity
V130003_29350	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
V130003_29360	COG5380	lipid catabolic process
V130003_29410	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V130003_29420	COG4605	iron ion homeostasis
V130003_29430	COG4604	ABC transporter, ATP-binding protein
V130003_29440	COG2207	Transcriptional regulator
V130003_29470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
V130003_29560	COG0745	RESPONSE REGULATOR receiver
V130003_29580	COG3623	hexulose-6-phosphate isomerase
V130003_29590	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
V130003_29600	COG0561	phosphatase activity
V130003_29690	COG0745	RESPONSE REGULATOR receiver
V130003_29700	COG5002	protein histidine kinase activity
V130003_29730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V130003_29800	COG1686	Belongs to the peptidase S11 family
V130003_29840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V130003_29840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V130003_29850	COG0509	glycine decarboxylation via glycine cleavage system
V130003_29860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
V130003_29880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
V130003_29910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
V130003_29920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
V130003_30010	COG1357	PFAM Pentapeptide repeats (8 copies)
V130003_30040	COG3549	Plasmid maintenance system killer
V130003_30050	COG3093	addiction module antidote protein HigA
V130003_30160	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
V130003_30170	COG2944	sequence-specific DNA binding
V130003_30260	COG2161	toxin-antitoxin pair type II binding
V130003_30270	COG4115	mRNA cleavage
V130003_30360	COG2801	Transposase and inactivated derivatives
V130003_30380	COG1028	Short-chain dehydrogenase reductase Sdr
V130003_30570	COG3549	Plasmid maintenance system killer
V130003_30580	COG3093	addiction module antidote protein HigA
V130003_30690	COG5433	transposase activity
V130003_30700	COG2944	sequence-specific DNA binding
V130003_30720	COG2161	toxin-antitoxin pair type II binding
V130003_30730	COG4115	mRNA cleavage
V130003_30870	COG1328	CTP reductase activity
V130003_30880	COG0602	queuosine metabolic process
V130003_30900	COG4067	protein conserved in archaea
V130003_30900	COG0189	ligase activity
V130003_30910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V130003_30910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V130003_30910	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
V130003_30920	COG1105	Belongs to the carbohydrate kinase PfkB family
V130003_30930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V130003_30930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V130003_30940	COG1609	Transcriptional regulator
V130003_30950	COG0420	3'-5' exonuclease activity
V130003_30960	COG0419	ATPase involved in DNA repair
V130003_30970	COG0784	Response regulator, receiver
V130003_30970	COG2205	protein histidine kinase activity
V130003_30980	COG0156	8-amino-7-oxononanoate synthase activity
V130003_31000	COG0038	chloride channel
V130003_31010	COG0523	cobalamin synthesis protein
V130003_31030	COG3158	transport of potassium into the cell
V130003_31040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V130003_31040	COG0674	pyruvate-flavodoxin oxidoreductase activity
V130003_31040	COG1013	pyruvate-flavodoxin oxidoreductase activity
V130003_31040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
V130003_31050	COG2205	protein histidine kinase activity
V130003_31060	COG0745	RESPONSE REGULATOR receiver
V130003_31070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V130003_31080	COG0586	Pfam SNARE associated Golgi protein
V130003_31100	COG2200	EAL domain
V130003_31120	COG3038	cytochrome b561
V130003_31140	COG2116	formate transmembrane transporter activity
V130003_31150	COG0583	DNA-binding transcription factor activity
V130003_31170	COG3593	DNA synthesis involved in DNA repair
V130003_31180	COG0737	Belongs to the 5'-nucleotidase family
V130003_31220	COG2824	Alkylphosphonate utilization operon protein PhnA
V130003_31280	COG2199	diguanylate cyclase activity
V130003_31320	COG3706	GGDEF domain
V130003_31350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
V130003_31360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
V130003_31380	COG0745	RESPONSE REGULATOR receiver
V130003_31410	COG3140	Belongs to the UPF0181 family
V130003_31420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
V130003_31470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
V130003_31520	COG0023	Translation Initiation Factor
V130003_31560	COG0045	succinate-CoA ligase (ADP-forming) activity
V130003_31560	COG1042	CoA-binding domain protein
V130003_31560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V130003_31570	COG0583	DNA-binding transcription factor activity
V130003_31580	COG4771	TonB-dependent receptor
V130003_31620	COG2050	protein possibly involved in aromatic compounds catabolism
V130003_31670	COG0625	glutathione transferase activity
V130003_31700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
V130003_31710	COG4172	Belongs to the ABC transporter superfamily
V130003_31720	COG4239	(ABC) transporter, permease
V130003_31730	COG4174	ABC transporter (Permease)
V130003_31740	COG4166	transmembrane transport
V130003_31790	COG3104	oligopeptide transport
V130003_31830	COG3842	ATPase activity
V130003_31840	COG1840	ABC-type Fe3 transport system, periplasmic component
V130003_31850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
V130003_31860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
V130003_31870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V130003_31880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V130003_31900	COG3842	ATPase activity
V130003_31920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V130003_31950	COG1175	transmembrane transport
V130003_31960	COG3833	ABC-type maltose transport systems, permease component
V130003_32000	COG1011	Hydrolase
V130003_32030	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
V130003_32040	COG1970	mechanosensitive ion channel activity
V130003_32050	COG2759	Belongs to the formate--tetrahydrofolate ligase family
V130003_32060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V130003_32060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V130003_32070	COG0302	gtp cyclohydrolase
V130003_32090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V130003_32110	COG2897	thiosulfate sulfurtransferase activity
V130003_32130	COG2390	Transcriptional regulator
V130003_32150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
V130003_32220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V130003_32270	COG0583	DNA-binding transcription factor activity
V130003_32280	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
V130003_32360	COG0446	pyridine nucleotide-disulphide oxidoreductase
V130003_32460	COG1263	PTS System
V130003_32460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V130003_32470	COG1609	Transcriptional regulator
V130003_32480	COG1621	beta-fructofuranosidase activity
V130003_32490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V130003_32500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
V130003_32510	COG0840	transmembrane signaling receptor activity
V130003_32530	COG0545	Peptidyl-prolyl cis-trans isomerase
V130003_32540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V130003_32570	COG3069	C4-dicarboxylate transmembrane transporter activity
V130003_32580	COG1760	l-serine dehydratase
V130003_32590	COG2197	response regulator
V130003_32600	COG3850	Histidine kinase
V130003_32630	COG0243	molybdopterin cofactor binding
V130003_32670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V130003_32680	COG2197	response regulator
V130003_32690	COG3851	Histidine kinase
V130003_32700	COG2271	Major facilitator Superfamily
V130003_32710	COG1840	ABC-type Fe3 transport system, periplasmic component
V130003_32730	COG3842	ATPase activity
V130003_32740	COG3243	poly(R)-hydroxyalkanoic acid synthase
V130003_32760	COG0183	Belongs to the thiolase family
V130003_32780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V130003_32790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V130003_32820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V130003_32830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V130003_32850	COG1979	alcohol dehydrogenase
V130003_32880	COG4191	Histidine kinase
V130003_32900	COG2271	Major facilitator Superfamily
V130003_32910	COG0469	pyruvate kinase activity
V130003_32930	COG1879	ABC-type sugar transport system periplasmic component
V130003_32940	COG1803	Methylglyoxal synthase
V130003_32950	COG1335	isochorismatase
V130003_32960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
V130003_32970	COG0210	DNA helicase
V130003_32980	COG1289	transmembrane transporter activity
V130003_33040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
V130003_33050	COG4149	molybdate abc transporter
V130003_33060	COG0725	ABC transporter, periplasmic molybdate-binding protein
V130003_33070	COG1492	cobalamin metabolic process
V130003_33080	COG1492	cobalamin metabolic process
V130003_33100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
V130003_33150	COG5002	protein histidine kinase activity
V130003_33150	COG0784	Response regulator, receiver
V130003_33160	COG1879	ABC-type sugar transport system periplasmic component
V130003_33180	COG2827	Endonuclease containing a URI domain
V130003_33190	COG3132	Protein of unknown function, DUF480
V130003_33210	COG2926	Belongs to the UPF0265 family
V130003_33240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
V130003_33250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
V130003_33260	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
V130003_33270	COG0247	lactate metabolic process
V130003_33280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
V130003_33290	COG3118	belongs to the thioredoxin family
V130003_33320	COG4160	amino acid transport
V130003_33330	COG4215	(ABC) transporter
V130003_33340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V130003_33350	COG1126	abc transporter atp-binding protein
V130003_33360	COG2425	protein containing a von Willebrand factor type A (vWA) domain
V130003_33370	COG2425	protein containing a von Willebrand factor type A (vWA) domain
V130003_33390	COG0494	nUDIX hydrolase
V130003_33400	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
V130003_33420	COG1309	transcriptional regulator
V130003_33430	COG0513	Belongs to the DEAD box helicase family
V130003_33440	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
V130003_33460	COG0814	amino acid
V130003_33470	COG0840	transmembrane signaling receptor activity
V130003_33480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
V130003_33490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
V130003_33510	COG1984	allophanate hydrolase subunit 2
V130003_33540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
V130003_33550	COG4181	ATPase activity
V130003_33570	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V130003_33580	COG5001	Diguanylate cyclase
V130003_33580	COG1716	ATPase activity
V130003_33600	COG0484	heat shock protein binding
V130003_33630	COG0546	phosphoglycolate phosphatase activity
V130003_33660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V130003_33680	COG0513	Belongs to the DEAD box helicase family
V130003_33710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
V130003_33730	COG3046	protein related to deoxyribodipyrimidine photolyase
V130003_33740	COG3397	chitin binding
V130003_33750	COG3397	chitin binding
V130003_33760	COG3227	Zinc metalloprotease (Elastase)
V130003_33780	COG0010	Belongs to the arginase family
V130003_33790	COG1166	arginine decarboxylase activity
V130003_33810	COG2239	Acts as a magnesium transporter
V130003_33820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
V130003_33830	COG0459	protein refolding
V130003_33850	COG0527	aspartate kinase activity
V130003_33860	COG0662	Cupin 2, conserved barrel domain protein
V130003_33870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
V130003_33880	COG0456	acetyltransferase
V130003_33890	COG2154	pterin-4-alpha-carbinolamine dehydratase
V130003_33900	COG3186	Phenylalanine-4-hydroxylase
V130003_33910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V130003_34000	COG1253	flavin adenine dinucleotide binding
V130003_34010	COG1765	OsmC-like protein
V130003_34050	COG1280	lysine exporter protein (LysE YggA)
V130003_34060	COG0531	amino acid
V130003_34090	COG4989	oxidoreductase activity
V130003_34100	COG0366	Alpha amylase catalytic
V130003_34130	COG2067	long-chain fatty acid transport protein
V130003_34140	COG2267	carboxylic ester hydrolase activity
V130003_34150	COG2267	carboxylic ester hydrolase activity
V130003_34170	COG3227	Zinc metalloprotease (Elastase)
V130003_34180	COG3047	cAMP biosynthetic process
V130003_34200	COG1686	Belongs to the peptidase S11 family
V130003_34210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
V130003_34220	COG1271	oxidase subunit
V130003_34230	COG1271	oxidase subunit
V130003_34240	COG1294	oxidase, subunit
V130003_34270	COG3048	D-serine ammonia-lyase activity
V130003_34280	COG0583	DNA-binding transcription factor activity
V130003_34360	COG1063	alcohol dehydrogenase
V130003_34450	COG3501	Rhs element vgr protein
V130003_34710	COG0798	PFAM Bile acid sodium symporter
V130003_34720	COG0640	Transcriptional regulator
V130003_34770	COG1278	Cold shock
V130003_34820	COG4626	Terminase
V130003_34820	COG1802	Transcriptional regulator
V130003_34880	COG0582	viral genome integration into host DNA
V130003_34930	COG1063	alcohol dehydrogenase
V130003_34940	COG0156	8-amino-7-oxononanoate synthase activity
V130003_34950	COG2873	o-acetylhomoserine
V130003_34970	COG0346	lactoylglutathione lyase activity
V130003_35010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
V130003_35020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V130003_35030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
V130003_35040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
V130003_35050	COG0363	glucosamine-6-phosphate deaminase activity
V130003_35060	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
V130003_35110	COG1929	Belongs to the glycerate kinase type-1 family
V130003_35130	COG0748	coenzyme F420 binding
V130003_35140	COG3721	Heme iron utilization protein
V130003_35160	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
V130003_35170	COG0811	peptide transport
V130003_35180	COG0848	biopolymer transport protein
V130003_35190	COG4558	Periplasmic binding protein
V130003_35200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V130003_35210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
V130003_35280	COG0633	Ferredoxin
V130003_35280	COG3217	Mosc domain protein beta barrel domain protein
V130003_35280	COG0633	Ferredoxin
V130003_35280	COG3217	Mosc domain protein beta barrel domain protein
V130003_35290	COG0418	dihydroorotase activity
V130003_35310	COG3152	Membrane
V130003_35330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V130003_35340	COG2354	Protein conserved in bacteria
V130003_35350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V130003_35360	COG1278	Cold shock
V130003_35410	COG2199	diguanylate cyclase activity
V130003_35420	COG2199	diguanylate cyclase activity
V130003_35430	COG1349	DNA-binding transcription factor activity
V130003_35460	COG3833	ABC-type maltose transport systems, permease component
V130003_35470	COG1175	transmembrane transport
V130003_35490	COG3842	ATPase activity
V130003_35500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V130003_35530	COG0393	Putative heavy-metal-binding
V130003_35550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V130003_35560	COG0784	Response regulator, receiver
V130003_35560	COG0835	chemotaxis
V130003_35570	COG1846	Transcriptional regulator
V130003_35580	COG3706	GGDEF domain
V130003_35650	COG0583	DNA-binding transcription factor activity
V130003_35660	COG5001	Diguanylate cyclase
V130003_35680	COG1741	Belongs to the pirin family
V130003_35690	COG3123	guanosine phosphorylase activity
V130003_35710	COG2211	Major facilitator Superfamily
V130003_35740	COG1067	ATP-dependent peptidase activity
V130003_35760	COG4172	Belongs to the ABC transporter superfamily
V130003_35800	COG0583	DNA-binding transcription factor activity
V130003_35810	COG1620	l-lactate permease
V130003_35840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
V130003_35860	COG0840	transmembrane signaling receptor activity
V130003_35890	COG0513	Belongs to the DEAD box helicase family
V130003_35900	COG0583	DNA-binding transcription factor activity
V130003_35920	COG1902	pentaerythritol trinitrate reductase activity
V130003_35940	COG1132	(ABC) transporter
V130003_35970	COG1902	pentaerythritol trinitrate reductase activity
V130003_35990	COG1280	lysine exporter protein (LysE YggA)
V130003_36000	COG2207	Transcriptional regulator
V130003_36040	COG1846	Transcriptional regulator
V130003_36050	COG1764	response to oxidative stress
V130003_36060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V130003_36070	COG0697	spore germination
V130003_36090	COG0700	Nucleoside recognition
V130003_36100	COG3366	ferrous iron transmembrane transporter activity
V130003_36110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
V130003_36130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
V130003_36140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
V130003_36150	COG2259	Doxx family
V130003_36200	COG0363	glucosamine-6-phosphate deaminase activity
V130003_36230	COG4580	involved in the transport of maltose and maltodextrins
V130003_36260	COG0840	transmembrane signaling receptor activity
V130003_36280	COG0840	transmembrane signaling receptor activity
V130003_36300	COG3706	GGDEF domain
V130003_36360	COG2801	Transposase and inactivated derivatives
V130003_36370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V130003_36380	COG1126	abc transporter atp-binding protein
V130003_36400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V130003_36410	COG4597	amino acid ABC transporter
V130003_36420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
V130003_36430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V130003_36430	COG2213	PTS system mannitol-specific
V130003_36440	COG0246	Mannitol dehydrogenase
V130003_36450	COG3722	fumarate hydratase activity
V130003_36460	COG0673	inositol 2-dehydrogenase activity
V130003_36520	COG2910	NAD(P)H-binding
V130003_36540	COG0840	transmembrane signaling receptor activity
V130003_36550	COG4221	oxidoreductase activity
V130003_36570	COG1901	pseudouridine methyltransferase
V130003_36590	COG0531	amino acid
V130003_36600	COG1982	Orn Lys Arg decarboxylase major
V130003_36650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V130003_36700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
V130003_36780	COG0745	RESPONSE REGULATOR receiver
V130003_36830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V130003_36840	COG0840	transmembrane signaling receptor activity
V130003_36860	COG0835	chemotaxis
V130003_36870	COG0835	chemotaxis
V130003_36880	COG0643	Histidine kinase
V130003_36880	COG2198	Histidine kinase
V130003_36920	COG0601	transmembrane transport
V130003_36930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V130003_36950	COG2194	sulfuric ester hydrolase activity
V130003_36960	COG0642	Histidine kinase
V130003_36970	COG0745	RESPONSE REGULATOR receiver
V130003_37030	COG1444	tRNA N-acetyltransferase activity
V130003_37040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine