locus-tag	class	description
HPY12_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY12_00010	COG0592	DNA-directed DNA polymerase activity
HPY12_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY12_00020	COG0187	DNA topoisomerase II activity
HPY12_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY12_00035	COG3977	Valine--pyruvate aminotransferase
HPY12_00040	COG0751	glycine-tRNA ligase activity
HPY12_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY12_00050	COG2119	membrane
HPY12_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY12_00070	COG0604	alcohol dehydrogenase
HPY12_00080	COG0129	dihydroxy-acid dehydratase activity
HPY12_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY12_00100	COG0606	chelatase, subunit chli
HPY12_00105	COG0204	Acyl-transferase
HPY12_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY12_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY12_00125	COG3084	Protein conserved in bacteria
HPY12_00130	COG4326	sporulation control protein
HPY12_00135	COG1272	protein, Hemolysin III
HPY12_00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY12_00150	COG0569	domain protein
HPY12_00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY12_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY12_00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY12_00165	COG0242	peptide deformylase activity
HPY12_00170	COG1652	LysM domain
HPY12_00175	COG0758	DNA mediated transformation
HPY12_00180	COG2922	Belongs to the Smg family
HPY12_00185	COG0551	DNA topoisomerase type I activity
HPY12_00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY12_00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY12_00205	COG0408	coproporphyrinogen oxidase activity
HPY12_00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY12_00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY12_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY12_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY12_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY12_00280	COG2104	thiamine diphosphate biosynthetic process
HPY12_00285	COG2022	thiamine diphosphate biosynthetic process
HPY12_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY12_00295	COG0006	proline dipeptidase activity
HPY12_00295	COG0006	proline dipeptidase activity
HPY12_00315	COG1522	sequence-specific DNA binding
HPY12_00320	COG5002	protein histidine kinase activity
HPY12_00320	COG5001	Diguanylate cyclase
HPY12_00340	COG0589	response to stress
HPY12_00345	COG1528	Iron-storage protein
HPY12_00355	COG2081	HI0933 family
HPY12_00365	COG1322	Protein conserved in bacteria
HPY12_00370	COG2226	methyltransferase
HPY12_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY12_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY12_00395	COG0805	protein transport
HPY12_00400	COG1858	cytochrome C peroxidase
HPY12_00405	COG0534	Mate efflux family protein
HPY12_00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY12_00420	COG2937	Belongs to the GPAT DAPAT family
HPY12_00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY12_00430	COG3161	chorismate lyase activity
HPY12_00440	COG0840	transmembrane signaling receptor activity
HPY12_00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY12_00455	COG0084	hydrolase, TatD family'
HPY12_00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY12_00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY12_00490	COG3078	GTPase activator activity
HPY12_00505	COG3071	HemY protein
HPY12_00510	COG2959	enzyme of heme biosynthesis
HPY12_00515	COG1587	Uroporphyrinogen-III synthase
HPY12_00520	COG0181	hydroxymethylbilane synthase activity
HPY12_00525	COG3072	Adenylate cyclase
HPY12_00530	COG1965	Belongs to the frataxin family
HPY12_00540	COG0019	diaminopimelate decarboxylase activity
HPY12_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY12_00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY12_00560	COG1011	Hydrolase
HPY12_00565	COG2199	diguanylate cyclase activity
HPY12_00565	COG3287	FIST C domain
HPY12_00565	COG2200	EAL domain
HPY12_00580	COG0561	phosphatase activity
HPY12_00585	COG2267	carboxylic ester hydrolase activity
HPY12_00590	COG1280	lysine exporter protein (LysE YggA)
HPY12_00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY12_00600	COG0783	Belongs to the Dps family
HPY12_00630	COG0742	ribosomal rna small subunit methyltransferase
HPY12_00635	COG0552	protein localization to endoplasmic reticulum
HPY12_00640	COG2884	Cell division ATP-binding protein ftsE
HPY12_00645	COG2177	Part of the ABC transporter FtsEX involved in
HPY12_00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY12_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY12_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY12_00675	COG4206	TonB-dependent receptor
HPY12_00680	COG1404	Belongs to the peptidase S8 family
HPY12_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY12_00755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY12_00760	COG3300	MHYT domain
HPY12_00760	COG5001	Diguanylate cyclase
HPY12_00770	COG3852	Histidine kinase
HPY12_00780	COG0174	glutamine synthetase
HPY12_00800	COG1295	ribonuclease BN
HPY12_00805	COG1490	D-aminoacyl-tRNA deacylase activity
HPY12_00810	COG0456	acetyltransferase
HPY12_00820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY12_00825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY12_00830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY12_00835	COG3031	protein transport across the cell outer membrane
HPY12_00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY12_00850	COG1459	type II secretion system
HPY12_00855	COG2165	general secretion pathway protein
HPY12_00860	COG2165	general secretion pathway protein
HPY12_00865	COG2165	general secretion pathway protein
HPY12_00870	COG4795	General secretion pathway protein
HPY12_00875	COG3156	type II secretion system protein K
HPY12_00880	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY12_00885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY12_00895	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY12_00900	COG0494	nUDIX hydrolase
HPY12_00910	COG1040	competence protein
HPY12_00920	COG0596	Alpha beta hydrolase
HPY12_00930	COG2183	response to ionizing radiation
HPY12_00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY12_00940	COG0745	RESPONSE REGULATOR receiver
HPY12_00950	COG2233	PERMEase
HPY12_00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY12_00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY12_00965	COG1758	RNA polymerase activity
HPY12_00970	COG0194	GDP metabolic process
HPY12_00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY12_00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY12_01000	COG4232	protein-disulfide reductase activity
HPY12_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY12_01015	COG1027	Aspartate ammonia-lyase
HPY12_01020	COG3706	GGDEF domain
HPY12_01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY12_01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY12_01040	COG2205	protein histidine kinase activity
HPY12_01045	COG0745	RESPONSE REGULATOR receiver
HPY12_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY12_01060	COG0205	6-phosphofructokinase activity
HPY12_01065	COG1494	fructose-1,6-bisphosphatase
HPY12_01070	COG3074	FtsZ-dependent cytokinesis
HPY12_01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY12_01080	COG0527	aspartate kinase activity
HPY12_01080	COG0460	homoserine dehydrogenase
HPY12_01085	COG0626	cystathionine gamma-synthase activity
HPY12_01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY12_01095	COG0281	malic enzyme
HPY12_01100	COG0254	rRNA binding
HPY12_01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY12_01110	COG1609	Transcriptional regulator
HPY12_01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY12_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY12_01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY12_01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY12_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY12_01140	COG0534	Mate efflux family protein
HPY12_01145	COG0149	triose-phosphate isomerase activity
HPY12_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY12_01175	COG0459	protein refolding
HPY12_01185	COG1509	lysine 2,3-aminomutase activity
HPY12_01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY12_01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY12_01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY12_01210	COG1053	succinate dehydrogenase
HPY12_01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY12_01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY12_01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY12_01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY12_01235	COG1045	serine acetyltransferase
HPY12_01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY12_01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY12_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY12_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY12_01265	COG0137	argininosuccinate synthase activity
HPY12_01270	COG0165	Argininosuccinate lyase
HPY12_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY12_01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY12_01285	COG0678	peroxiredoxin activity
HPY12_01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY12_01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY12_01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY12_01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY12_01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY12_01350	COG0546	phosphoglycolate phosphatase activity
HPY12_01355	COG0180	Tryptophanyl-tRNA synthetase
HPY12_01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY12_01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY12_01405	COG3954	Phosphoribulokinase
HPY12_01415	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY12_01425	COG0488	(ABC) transporter
HPY12_01430	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY12_01445	COG1047	Peptidyl-prolyl cis-trans
HPY12_01460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY12_01470	COG3083	sulfuric ester hydrolase activity
HPY12_01475	COG0557	exoribonuclease II activity
HPY12_01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY12_01485	COG0051	transcription antitermination factor activity, RNA binding
HPY12_01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY12_01495	COG0088	Forms part of the polypeptide exit tunnel
HPY12_01500	COG0089	rRNA binding
HPY12_01505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY12_01510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY12_01515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY12_01520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY12_01525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY12_01530	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY12_01535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY12_01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY12_01545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY12_01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY12_01555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY12_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY12_01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY12_01575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY12_01580	COG1841	ribosomal large subunit assembly
HPY12_01590	COG0201	protein transport
HPY12_01595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY12_01600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY12_01605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY12_01610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY12_01615	COG0202	RNA polymerase activity
HPY12_01620	COG0203	ribosomal protein L17
HPY12_01630	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY12_01635	COG3061	Opacity-associated protein A
HPY12_01635	COG3266	domain, Protein
HPY12_01640	COG0697	spore germination
HPY12_01645	COG2153	protein acetylation
HPY12_01650	COG0513	Belongs to the DEAD box helicase family
HPY12_01660	COG0737	Belongs to the 5'-nucleotidase family
HPY12_01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY12_01665	COG1648	precorrin-2 dehydrogenase activity
HPY12_01670	COG0175	sulfate reduction
HPY12_01675	COG2895	sulfate adenylyltransferase (ATP) activity
HPY12_01680	COG0529	Catalyzes the synthesis of activated sulfate
HPY12_01700	COG1136	(ABC) transporter
HPY12_01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY12_01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY12_01725	COG0729	surface antigen
HPY12_01735	COG2105	PFAM AIG2 family protein
HPY12_01740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY12_01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY12_01755	COG0163	prenyltransferase activity
HPY12_01765	COG1178	ABC-type Fe3 transport system permease component
HPY12_01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY12_01775	COG3028	Belongs to the UPF0307 family
HPY12_01780	COG0312	modulator of DNA gyrase
HPY12_01785	COG2239	Acts as a magnesium transporter
HPY12_01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_01795	COG1660	Displays ATPase and GTPase activities
HPY12_01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY12_01815	COG1137	ATPase activity
HPY12_01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY12_01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY12_01835	COG0517	IMP dehydrogenase activity
HPY12_01845	COG1127	ABC transporter
HPY12_01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY12_01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY12_01860	COG2854	intermembrane phospholipid transfer
HPY12_01870	COG5007	Belongs to the BolA IbaG family
HPY12_01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY12_01885	COG0251	oxidation-reduction process
HPY12_01895	COG0540	Belongs to the ATCase OTCase family
HPY12_01905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY12_01915	COG0564	pseudouridine synthase activity
HPY12_01920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY12_01925	COG0525	valine-tRNA ligase activity
HPY12_01930	COG2927	DNA polymerase III (CHI subunit)
HPY12_01935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY12_01940	COG0795	lipopolysaccharide-transporting ATPase activity
HPY12_01945	COG0795	lipopolysaccharide-transporting ATPase activity
HPY12_01960	COG3437	response regulator, receiver
HPY12_02005	COG0066	3-isopropylmalate dehydratase activity
HPY12_02010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY12_02015	COG0473	3-isopropylmalate dehydrogenase activity
HPY12_02050	COG0028	Belongs to the TPP enzyme family
HPY12_02055	COG0440	acetolactate synthase activity
HPY12_02060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY12_02065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY12_02070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY12_02080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY12_02085	COG3079	Belongs to the UPF0149 family
HPY12_02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY12_02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY12_02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY12_02120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY12_02125	COG1595	DNA-templated transcription, initiation
HPY12_02140	COG3086	response to oxidative stress
HPY12_02145	COG0481	GTPase activity
HPY12_02155	COG0571	ribonuclease III activity
HPY12_02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY12_02165	COG1381	Involved in DNA repair and RecF pathway recombination
HPY12_02170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY12_02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY12_02210	COG3956	TIGRFAM MazG family protein
HPY12_02215	COG0504	CTP synthase activity
HPY12_02220	COG0148	phosphopyruvate hydratase activity
HPY12_02230	COG3267	Type II secretory pathway component ExeA
HPY12_02230	COG3409	Peptidoglycan-binding domain 1 protein
HPY12_02240	COG4991	sh3 domain protein
HPY12_02245	COG0306	phosphate transporter
HPY12_02250	COG1392	Phosphate transport regulator
HPY12_02255	COG3025	triphosphatase activity
HPY12_02265	COG0840	transmembrane signaling receptor activity
HPY12_02270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY12_02275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY12_02275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY12_02280	COG1538	Outer membrane efflux protein
HPY12_02285	COG0494	nUDIX hydrolase
HPY12_02290	COG3151	Protein conserved in bacteria
HPY12_02300	COG3150	esterase
HPY12_02305	COG0187	DNA topoisomerase II activity
HPY12_02310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY12_02320	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY12_02325	COG0237	dephospho-CoA kinase activity
HPY12_02335	COG1459	type II secretion system
HPY12_02340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY12_02360	COG0716	FMN binding
HPY12_02365	COG4974	Belongs to the 'phage' integrase family
HPY12_02370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY12_02375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY12_02380	COG0737	Belongs to the 5'-nucleotidase family
HPY12_02385	COG2186	Transcriptional regulator
HPY12_02390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY12_02395	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY12_02400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY12_02415	COG3116	cell division
HPY12_02420	COG0768	penicillin binding
HPY12_02425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY12_02430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY12_02440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY12_02445	COG0772	Belongs to the SEDS family
HPY12_02455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY12_02460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY12_02465	COG0849	cell division
HPY12_02470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY12_02475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY12_02485	COG0653	protein targeting
HPY12_02490	COG0494	nUDIX hydrolase
HPY12_02495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY12_02505	COG0505	Belongs to the CarA family
HPY12_02510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY12_02525	COG0730	response to heat
HPY12_02530	COG0583	DNA-binding transcription factor activity
HPY12_02535	COG2860	membrane
HPY12_02540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY12_02550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY12_02560	COG0493	'glutamate synthase
HPY12_02565	COG0067	glutamate synthase
HPY12_02565	COG0069	glutamate synthase activity
HPY12_02565	COG0070	glutamate synthase
HPY12_02575	COG0070	glutamate synthase
HPY12_02575	COG0067	glutamate synthase
HPY12_02575	COG0069	glutamate synthase activity
HPY12_02580	COG1242	4 iron, 4 sulfur cluster binding
HPY12_02590	COG2198	Histidine kinase
HPY12_02590	COG0784	Response regulator, receiver
HPY12_02590	COG5002	protein histidine kinase activity
HPY12_02595	COG0745	RESPONSE REGULATOR receiver
HPY12_02610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY12_02630	COG0083	homoserine kinase activity
HPY12_02635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY12_02640	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY12_02645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY12_02650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY12_02665	COG1115	amino acid carrier protein
HPY12_02680	COG0084	hydrolase, TatD family'
HPY12_02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY12_02695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY12_02700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY12_02705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY12_02710	COG0813	purine-nucleoside phosphorylase activity
HPY12_02720	COG0560	Phosphoserine phosphatase
HPY12_02730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY12_02735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY12_02740	COG1022	Amp-dependent synthetase and ligase
HPY12_02755	COG3250	beta-galactosidase activity
HPY12_02760	COG1609	Transcriptional regulator
HPY12_02765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY12_02780	COG0569	domain protein
HPY12_02780	COG0189	ligase activity
HPY12_02785	COG0456	acetyltransferase
HPY12_02795	COG2171	N-acyltransferase activity
HPY12_02800	COG3141	response to X-ray
HPY12_02815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY12_02820	COG1074	ATP-dependent DNA helicase activity
HPY12_02825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY12_02835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY12_02835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY12_02845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY12_02850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY12_02855	COG2166	iron-sulfur cluster assembly
HPY12_02860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY12_02865	COG0693	protein deglycase activity
HPY12_02870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY12_02875	COG3248	Nucleoside-binding outer membrane protein
HPY12_02885	COG1595	DNA-templated transcription, initiation
HPY12_02900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY12_02910	COG2813	Specifically methylates the guanine in position
HPY12_02915	COG0271	Belongs to the BolA IbaG family
HPY12_02920	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY12_02925	COG1805	sodium ion transport
HPY12_02930	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY12_02935	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY12_02940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY12_02945	COG2871	sodium ion transport
HPY12_02950	COG1477	protein flavinylation
HPY12_02970	COG3706	GGDEF domain
HPY12_02975	COG0733	neurotransmitter:sodium symporter activity
HPY12_02985	COG0189	ligase activity
HPY12_02990	COG0189	ligase activity
HPY12_02990	COG4067	protein conserved in archaea
HPY12_02995	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY12_03000	COG2252	PERMEase
HPY12_03005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY12_03020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY12_03025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY12_03030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY12_03035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY12_03035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY12_03050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY12_03055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY12_03060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY12_03065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY12_03075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY12_03080	COG0024	Methionine aminopeptidase
HPY12_03085	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY12_03090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY12_03095	COG0528	UMP kinase activity
HPY12_03100	COG0233	cytoplasmic translational termination
HPY12_03105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY12_03110	COG0575	Belongs to the CDS family
HPY12_03115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY12_03120	COG0750	zinc metalloprotease
HPY12_03130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY12_03135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY12_03140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY12_03145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY12_03150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY12_03155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY12_03160	COG0587	DNA-directed DNA polymerase activity
HPY12_03165	COG0825	malonyl-CoA metabolic process
HPY12_03170	COG0037	tRNA processing
HPY12_03180	COG3479	Phenolic acid decarboxylase
HPY12_03185	COG0347	Belongs to the P(II) protein family
HPY12_03190	COG3021	interspecies interaction between organisms
HPY12_03195	COG0741	lytic transglycosylase activity
HPY12_03195	COG1388	LysM domain
HPY12_03200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY12_03205	COG2226	methyltransferase
HPY12_03210	COG0328	RNA-DNA hybrid ribonuclease activity
HPY12_03225	COG1960	acyl-CoA dehydrogenase activity
HPY12_03230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY12_03235	COG0121	glutamine amidotransferase
HPY12_03240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY12_03245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY12_03250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY12_03255	COG3706	GGDEF domain
HPY12_03260	COG1187	pseudouridine synthase activity
HPY12_03265	COG2840	Smr protein MutS2
HPY12_03295	COG2608	mercury ion transmembrane transporter activity
HPY12_03295	COG2217	Heavy metal translocating P-type atpase
HPY12_03300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY12_03315	COG1629	transport
HPY12_03315	COG4774	siderophore transport
HPY12_03320	COG2375	cellular response to nickel ion
HPY12_03325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY12_03325	COG2226	methyltransferase
HPY12_03325	COG3433	isochorismatase activity
HPY12_03360	COG0835	chemotaxis
HPY12_03360	COG0784	Response regulator, receiver
HPY12_03365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY12_03370	COG1815	bacterial-type flagellum-dependent cell motility
HPY12_03385	COG1749	Flagellar hook protein flgE
HPY12_03390	COG4787	bacterial-type flagellum-dependent cell motility
HPY12_03400	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY12_03405	COG1706	bacterial-type flagellum-dependent cell motility
HPY12_03410	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY12_03410	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY12_03425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY12_03430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY12_03515	COG0012	GTP binding
HPY12_03520	COG0193	aminoacyl-tRNA hydrolase activity
HPY12_03525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY12_03530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY12_03535	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY12_03540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY12_03545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY12_03550	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY12_03560	COG2912	Transglutaminase-like superfamily
HPY12_03565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY12_03570	COG0737	Belongs to the 5'-nucleotidase family
HPY12_03575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY12_03580	COG2233	PERMEase
HPY12_03600	COG1393	Belongs to the ArsC family
HPY12_03605	COG4783	chaperone-mediated protein folding
HPY12_03625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY12_03640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY12_03650	COG1876	peptidase activity
HPY12_03660	COG1393	Belongs to the ArsC family
HPY12_03680	COG2837	iron assimilation
HPY12_03685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY12_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY12_03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY12_03700	COG1334	flagellar protein FlaG
HPY12_03705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY12_03715	COG1516	flagellar protein fliS
HPY12_03725	COG4191	Histidine kinase
HPY12_03735	COG1677	Flagellar hook-basal body complex protein FliE
HPY12_03745	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY12_03750	COG1317	bacterial-type flagellum organization
HPY12_03775	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY12_03800	COG1987	bacterial-type flagellum assembly
HPY12_03805	COG1684	flagellar biosynthetic protein fliR
HPY12_03815	COG2840	Smr protein MutS2
HPY12_03820	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY12_03825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY12_03830	COG2860	membrane
HPY12_03835	COG3101	peptidyl-lysine hydroxylation
HPY12_03845	COG0431	NADPH-dependent FMN reductase
HPY12_03850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY12_03850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY12_03855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY12_03870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY12_03875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY12_03880	COG0735	belongs to the Fur family
HPY12_03890	COG0583	DNA-binding transcription factor activity
HPY12_03900	COG1346	cytolysis
HPY12_03915	COG0596	Alpha beta hydrolase
HPY12_03920	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY12_03925	COG0033	Phosphoglucomutase
HPY12_03935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY12_03940	COG0372	Belongs to the citrate synthase family
HPY12_03945	COG2009	succinate dehydrogenase
HPY12_03950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY12_03955	COG1053	succinate dehydrogenase
HPY12_03965	COG0567	Dehydrogenase, E1 component
HPY12_03970	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY12_03975	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY12_03985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY12_03990	COG1121	(ABC) transporter
HPY12_03995	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY12_04000	COG4977	sequence-specific DNA binding
HPY12_04005	COG1918	ferrous iron import across plasma membrane
HPY12_04025	COG0018	arginyl-trna synthetase
HPY12_04035	COG1025	Belongs to the peptidase M16 family
HPY12_04040	COG2062	phosphohistidine phosphatase, SixA
HPY12_04070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY12_04075	COG0784	Response regulator, receiver
HPY12_04075	COG0643	Histidine kinase
HPY12_04075	COG2198	Histidine kinase
HPY12_04080	COG2201	protein-glutamate methylesterase activity
HPY12_04085	COG1192	Involved in chromosome partitioning
HPY12_04095	COG0835	chemotaxis
HPY12_04105	COG4133	protoheme IX ABC transporter activity
HPY12_04110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY12_04115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY12_04125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY12_04130	COG1138	Cytochrome C-type biogenesis protein
HPY12_04135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY12_04150	COG2853	Lipoprotein
HPY12_04170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY12_04175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY12_04180	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY12_04195	COG3083	sulfuric ester hydrolase activity
HPY12_04200	COG3082	Protein of unknown function (DUF1414)
HPY12_04205	COG3081	Nucleoid-associated protein
HPY12_04215	COG1757	Na H antiporter
HPY12_04220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY12_04225	COG2095	MarC family integral membrane protein
HPY12_04230	COG1012	belongs to the aldehyde dehydrogenase family
HPY12_04230	COG1454	alcohol dehydrogenase
HPY12_04240	COG0659	secondary active sulfate transmembrane transporter activity
HPY12_04245	COG1530	ribonuclease E activity
HPY12_04250	COG0564	pseudouridine synthase activity
HPY12_04255	COG0424	maF-like protein
HPY12_04260	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY12_04265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY12_04270	COG0416	fatty acid biosynthetic process
HPY12_04275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY12_04285	COG1028	Short-chain dehydrogenase reductase Sdr
HPY12_04290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY12_04295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY12_04300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY12_04305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY12_04310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY12_04320	COG0084	hydrolase, TatD family'
HPY12_04325	COG1263	PTS System
HPY12_04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY12_04335	COG0733	neurotransmitter:sodium symporter activity
HPY12_04350	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY12_04360	COG1940	carbohydrate kinase activity
HPY12_04365	COG0784	Response regulator, receiver
HPY12_04365	COG0835	chemotaxis
HPY12_04380	COG2226	methyltransferase
HPY12_04390	COG0676	glucose-6-phosphate 1-epimerase activity
HPY12_04395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY12_04400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY12_04410	COG3139	Protein of unknown function (DUF1315)
HPY12_04415	COG0252	asparaginase activity
HPY12_04420	COG0616	signal peptide processing
HPY12_04425	COG1902	pentaerythritol trinitrate reductase activity
HPY12_04425	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY12_04430	COG0788	formyltetrahydrofolate deformylase activity
HPY12_04440	COG1199	ATP-dependent helicase activity
HPY12_04445	COG1214	PFAM Peptidase M22, glycoprotease
HPY12_04460	COG0596	Alpha beta hydrolase
HPY12_04465	COG0318	PFAM AMP-dependent synthetase and ligase
HPY12_04470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY12_04490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY12_04495	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY12_04500	COG0436	Aminotransferase
HPY12_04505	COG1169	isochorismate synthase
HPY12_04510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY12_04515	COG0596	Alpha beta hydrolase
HPY12_04535	COG3135	benzoate transporter
HPY12_04540	COG1396	sequence-specific DNA binding
HPY12_04545	COG0840	transmembrane signaling receptor activity
HPY12_04555	COG0477	Major facilitator Superfamily
HPY12_04575	COG3015	lipoprotein NlpE involved in copper resistance
HPY12_04580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY12_04585	COG2894	cell division
HPY12_04590	COG0850	regulation of cytokinetic process
HPY12_04595	COG3100	YcgL domain-containing protein
HPY12_04600	COG2951	lytic endotransglycosylase activity
HPY12_04610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY12_04615	COG3325	Belongs to the glycosyl hydrolase 18 family
HPY12_04615	COG3469	chitinase activity
HPY12_04620	COG3005	denitrification pathway
HPY12_04625	COG0243	molybdopterin cofactor binding
HPY12_04640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY12_04650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY12_04685	COG4589	Belongs to the CDS family
HPY12_04695	COG5001	Diguanylate cyclase
HPY12_04695	COG3300	MHYT domain
HPY12_04705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY12_04710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY12_04715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY12_04720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY12_04730	COG4191	Histidine kinase
HPY12_04740	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY12_04750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY12_04755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY12_04760	COG0776	regulation of translation
HPY12_04765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY12_04770	COG1555	photosystem II stabilization
HPY12_04775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY12_04780	COG0539	negative regulation of cytoplasmic translation
HPY12_04785	COG0776	regulation of translation
HPY12_04790	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY12_04795	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY12_04815	COG0583	DNA-binding transcription factor activity
HPY12_04825	COG0686	Belongs to the AlaDH PNT family
HPY12_04835	COG1674	ftsk spoiiie
HPY12_04840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY12_04845	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY12_04850	COG2186	Transcriptional regulator
HPY12_04865	COG0537	adenosine 5'-monophosphoramidase activity
HPY12_04890	COG3150	esterase
HPY12_04895	COG1252	NADH dehydrogenase
HPY12_04915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY12_04930	COG1136	(ABC) transporter
HPY12_04935	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY12_04945	COG2333	competence protein COMEC
HPY12_04945	COG0658	competence protein
HPY12_04950	COG1132	(ABC) transporter
HPY12_04955	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY12_04960	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY12_04965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY12_04970	COG2719	SpoVR family
HPY12_04975	COG2718	Belongs to the UPF0229 family
HPY12_04980	COG2766	serine protein kinase
HPY12_04985	COG3013	Belongs to the UPF0304 family
HPY12_04995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY12_05000	COG0840	transmembrane signaling receptor activity
HPY12_05010	COG1882	Formate acetyltransferase
HPY12_05035	COG4160	amino acid transport
HPY12_05040	COG0708	Exodeoxyribonuclease III
HPY12_05045	COG0840	transmembrane signaling receptor activity
HPY12_05060	COG0730	response to heat
HPY12_05065	COG1199	ATP-dependent helicase activity
HPY12_05070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY12_05075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY12_05080	COG3012	SEC-C Motif Domain Protein
HPY12_05085	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY12_05090	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY12_05095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY12_05100	COG0215	cysteine-tRNA ligase activity
HPY12_05105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY12_05110	COG0632	four-way junction helicase activity
HPY12_05120	COG1271	oxidase subunit
HPY12_05125	COG1294	oxidase, subunit
HPY12_05130	COG4890	Cyd operon protein YbgT
HPY12_05135	COG3790	cyd operon protein YbgE
HPY12_05140	COG0824	Thioesterase
HPY12_05145	COG0811	peptide transport
HPY12_05160	COG0823	Involved in the tonB-independent uptake of proteins
HPY12_05165	COG2885	chlorophyll binding
HPY12_05175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY12_05185	COG5002	protein histidine kinase activity
HPY12_05185	COG0784	Response regulator, receiver
HPY12_05195	COG1482	cell wall glycoprotein biosynthetic process
HPY12_05200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY12_05200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY12_05205	COG2207	Transcriptional regulator
HPY12_05215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY12_05220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY12_05225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY12_05235	COG1012	belongs to the aldehyde dehydrogenase family
HPY12_05240	COG3284	Transcriptional regulator
HPY12_05245	COG4628	conserved protein (DUF2132)
HPY12_05255	COG0415	Belongs to the DNA photolyase family
HPY12_05335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY12_05385	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HPY12_05440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY12_05455	COG0681	Belongs to the peptidase S26 family
HPY12_05500	COG3064	Membrane
HPY12_05530	COG2351	hydroxyisourate hydrolase activity
HPY12_05545	COG5492	domain, Protein
HPY12_05545	COG4932	domain protein
HPY12_05570	COG4796	Type ii and iii secretion system protein
HPY12_05590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY12_05595	COG1459	type II secretion system
HPY12_05615	COG2207	Transcriptional regulator
HPY12_05665	COG3710	Transcriptional regulator
HPY12_05670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY12_05745	COG0714	Associated with various cellular activities
HPY12_05810	COG3311	Transcriptional regulator
HPY12_05815	COG0582	viral genome integration into host DNA
HPY12_05830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY12_05840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY12_05840	COG3008	intermembrane lipid transfer
HPY12_05845	COG2995	paraquat-inducible protein a
HPY12_05850	COG1309	transcriptional regulator
HPY12_05855	COG1012	belongs to the aldehyde dehydrogenase family
HPY12_05875	COG1960	acyl-CoA dehydrogenase activity
HPY12_05880	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY12_05885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY12_05890	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY12_05895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY12_05910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY12_05915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY12_05920	COG0297	glycogen (starch) synthase activity
HPY12_05940	COG3070	regulator of competence-specific genes
HPY12_05945	COG1609	Transcriptional regulator
HPY12_05950	COG3381	protein complex oligomerization
HPY12_05955	COG0745	RESPONSE REGULATOR receiver
HPY12_05960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY12_05965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY12_05970	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY12_05975	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY12_05985	COG1979	alcohol dehydrogenase
HPY12_05990	COG2207	Transcriptional regulator
HPY12_06010	COG1032	radical SAM domain protein
HPY12_06015	COG5001	Diguanylate cyclase
HPY12_06020	COG0612	Peptidase, M16
HPY12_06035	COG0583	DNA-binding transcription factor activity
HPY12_06040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY12_06050	COG2350	Protein conserved in bacteria
HPY12_06055	COG1607	acyl-coa hydrolase
HPY12_06060	COG2917	probably involved in intracellular septation
HPY12_06070	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY12_06075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY12_06085	COG2116	formate transmembrane transporter activity
HPY12_06090	COG4459	periplasmic nitrate reductase
HPY12_06095	COG3005	denitrification pathway
HPY12_06100	COG0243	molybdopterin cofactor binding
HPY12_06120	COG1227	inorganic diphosphatase activity
HPY12_06135	COG4172	Belongs to the ABC transporter superfamily
HPY12_06150	COG4168	peptide transport system, permease
HPY12_06160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY12_06165	COG1842	Phage shock protein A
HPY12_06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY12_06195	COG2818	Glycosylase
HPY12_06200	COG0626	cystathionine gamma-synthase activity
HPY12_06210	COG0733	neurotransmitter:sodium symporter activity
HPY12_06215	COG0564	pseudouridine synthase activity
HPY12_06220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY12_06225	COG4136	ATPase activity
HPY12_06230	COG4135	transport system, permease component
HPY12_06235	COG4134	Bacterial extracellular solute-binding protein
HPY12_06245	COG3313	Fe-S protein
HPY12_06255	COG0842	Transport permease protein
HPY12_06260	COG1131	(ABC) transporter
HPY12_06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY12_06270	COG0814	amino acid
HPY12_06280	COG2239	Acts as a magnesium transporter
HPY12_06285	COG2205	protein histidine kinase activity
HPY12_06285	COG0784	Response regulator, receiver
HPY12_06300	COG4934	collagen metabolic process
HPY12_06330	COG0840	transmembrane signaling receptor activity
HPY12_06340	COG2203	Gaf domain
HPY12_06340	COG4251	negative regulation of phosphorylation
HPY12_06340	COG3706	GGDEF domain
HPY12_06340	COG5001	Diguanylate cyclase
HPY12_06345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY12_06350	COG5002	protein histidine kinase activity
HPY12_06365	COG1061	Type III restriction enzyme res subunit
HPY12_06370	COG1187	pseudouridine synthase activity
HPY12_06375	COG2814	Major facilitator Superfamily
HPY12_06385	COG0702	epimerase
HPY12_06390	COG0534	Mate efflux family protein
HPY12_06395	COG4181	ATPase activity
HPY12_06410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY12_06420	COG1748	Saccharopine dehydrogenase
HPY12_06435	COG1538	Outer membrane efflux protein
HPY12_06475	COG0583	DNA-binding transcription factor activity
HPY12_06485	COG1451	nucleotide metabolic process
HPY12_06500	COG3063	Type IV pilus biogenesis stability protein PilW
HPY12_06505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY12_06525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY12_06540	COG3290	protein histidine kinase activity
HPY12_06545	COG4565	transcriptional regulatory protein
HPY12_06555	COG0784	Response regulator, receiver
HPY12_06555	COG0835	chemotaxis
HPY12_06600	COG1085	galactose-1-phosphate uridylyltransferase
HPY12_06605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY12_06610	COG2017	converts alpha-aldose to the beta-anomer
HPY12_06615	COG3706	GGDEF domain
HPY12_06620	COG2199	diguanylate cyclase activity
HPY12_06620	COG2200	EAL domain
HPY12_06635	COG3527	Alpha-acetolactate decarboxylase
HPY12_06650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY12_06660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY12_06700	COG1271	oxidase subunit
HPY12_06705	COG1294	oxidase, subunit
HPY12_06710	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY12_06710	COG1136	(ABC) transporter
HPY12_06715	COG0577	efflux transmembrane transporter activity
HPY12_06715	COG1136	(ABC) transporter
HPY12_06720	COG0577	efflux transmembrane transporter activity
HPY12_06720	COG1136	(ABC) transporter
HPY12_06750	COG2723	6-phospho-beta-galactosidase activity
HPY12_06755	COG1609	Transcriptional regulator
HPY12_06760	COG0251	oxidation-reduction process
HPY12_06765	COG2731	YhcH YjgK YiaL family protein
HPY12_06770	COG0584	glycerophosphoryl diester phosphodiesterase
HPY12_06775	COG1349	DNA-binding transcription factor activity
HPY12_06780	COG3842	ATPase activity
HPY12_06785	COG0395	ABC-type sugar transport system, permease component
HPY12_06790	COG1175	transmembrane transport
HPY12_06805	COG0811	peptide transport
HPY12_06810	COG0811	peptide transport
HPY12_06815	COG0848	biopolymer transport protein
HPY12_06820	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY12_06830	COG1793	dna ligase
HPY12_06840	COG0534	Mate efflux family protein
HPY12_06850	COG3001	Fructosamine kinase
HPY12_06860	COG0791	NLP P60 protein
HPY12_06865	COG0840	transmembrane signaling receptor activity
HPY12_06865	COG3290	protein histidine kinase activity
HPY12_06880	COG1940	carbohydrate kinase activity
HPY12_06895	COG0746	molybdenum cofactor guanylyltransferase activity
HPY12_06900	COG3842	ATPase activity
HPY12_06905	COG4662	Binding-protein-dependent transport system inner membrane component
HPY12_06915	COG2204	response regulator
HPY12_06920	COG3852	Histidine kinase
HPY12_06925	COG0488	(ABC) transporter
HPY12_06930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY12_06960	COG3383	formate dehydrogenase (NAD+) activity
HPY12_06960	COG0243	molybdopterin cofactor binding
HPY12_06965	COG0437	4 iron, 4 sulfur cluster binding
HPY12_06980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY12_06985	COG1666	GTP binding
HPY12_06990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY12_07005	COG2996	Protein conserved in bacteria
HPY12_07020	COG2995	paraquat-inducible protein a
HPY12_07025	COG1132	(ABC) transporter
HPY12_07030	COG1956	GAF domain-containing protein
HPY12_07035	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY12_07050	COG0308	aminopeptidase N
HPY12_07065	COG0167	dihydroorotate dehydrogenase activity
HPY12_07075	COG0116	Belongs to the methyltransferase superfamily
HPY12_07075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY12_07100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY12_07105	COG1067	ATP-dependent peptidase activity
HPY12_07110	COG3120	sequence-specific DNA binding
HPY12_07210	COG3064	Membrane
HPY12_07210	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY12_07210	COG1073	alpha beta
HPY12_07215	COG2994	toxin metabolic process
HPY12_07240	COG2205	protein histidine kinase activity
HPY12_07240	COG0784	Response regulator, receiver
HPY12_07255	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY12_07270	COG2010	Cytochrome c
HPY12_07280	COG2217	Heavy metal translocating P-type atpase
HPY12_07295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY12_07300	COG0589	response to stress
HPY12_07305	COG0037	tRNA processing
HPY12_07325	COG3842	ATPase activity
HPY12_07335	COG1177	transmembrane transport
HPY12_07345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY12_07355	COG1115	amino acid carrier protein
HPY12_07380	COG3501	Rhs element vgr protein
HPY12_07390	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY12_07395	COG0840	transmembrane signaling receptor activity
HPY12_07400	COG2814	Major facilitator Superfamily
HPY12_07405	COG1566	PFAM secretion protein HlyD family protein
HPY12_07420	COG0513	Belongs to the DEAD box helicase family
HPY12_07430	COG0840	transmembrane signaling receptor activity
HPY12_07435	COG0840	transmembrane signaling receptor activity
HPY12_07435	COG3290	protein histidine kinase activity
HPY12_07440	COG0835	chemotaxis
HPY12_07445	COG2201	protein-glutamate methylesterase activity
HPY12_07455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY12_07460	COG2198	Histidine kinase
HPY12_07460	COG0784	Response regulator, receiver
HPY12_07460	COG0643	Histidine kinase
HPY12_07465	COG0643	Histidine kinase
HPY12_07465	COG2198	Histidine kinase
HPY12_07475	COG0745	RESPONSE REGULATOR receiver
HPY12_07490	COG0415	Belongs to the DNA photolyase family
HPY12_07495	COG0477	Major facilitator Superfamily
HPY12_07500	COG0583	DNA-binding transcription factor activity
HPY12_07510	COG0095	Lipoate-protein ligase
HPY12_07515	COG0443	Heat shock 70 kDa protein
HPY12_07525	COG1643	Atp-dependent helicase
HPY12_07555	COG0443	Heat shock 70 kDa protein
HPY12_07560	COG0443	Heat shock 70 kDa protein
HPY12_07565	COG3706	GGDEF domain
HPY12_07595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY12_07600	COG0602	queuosine metabolic process
HPY12_07605	COG0561	phosphatase activity
HPY12_07615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY12_07620	COG4597	amino acid ABC transporter
HPY12_07625	COG0765	amino acid transport
HPY12_07630	COG1126	abc transporter atp-binding protein
HPY12_07635	COG0670	Belongs to the BI1 family
HPY12_07640	COG2920	part of a sulfur-relay system
HPY12_07645	COG1254	Belongs to the acylphosphatase family
HPY12_07650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY12_07655	COG3706	GGDEF domain
HPY12_07665	COG2205	protein histidine kinase activity
HPY12_07665	COG3850	Histidine kinase
HPY12_07665	COG4999	Histidine kinase
HPY12_07665	COG3437	response regulator, receiver
HPY12_07670	COG3437	response regulator, receiver
HPY12_07675	COG0625	glutathione transferase activity
HPY12_07685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY12_07695	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY12_07725	COG0372	Belongs to the citrate synthase family
HPY12_07730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY12_07770	COG1566	PFAM secretion protein HlyD family protein
HPY12_07790	COG1129	ABC transporter
HPY12_07815	COG0745	RESPONSE REGULATOR receiver
HPY12_07820	COG5002	protein histidine kinase activity
HPY12_07825	COG3713	MltA-interacting MipA family protein
HPY12_07830	COG2990	Protein conserved in bacteria
HPY12_07840	COG4191	Histidine kinase
HPY12_07840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY12_07845	COG0471	metal ion transport
HPY12_07855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY12_07870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY12_07880	COG3768	UPF0283 membrane protein
HPY12_07885	COG3106	COG3106 Predicted ATPase
HPY12_07900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY12_07905	COG0494	nUDIX hydrolase
HPY12_07910	COG0814	amino acid
HPY12_07915	COG1760	l-serine dehydratase
HPY12_07920	COG0720	synthase
HPY12_07930	COG0017	Asparaginyl-tRNA synthetase
HPY12_07935	COG0351	phosphomethylpyrimidine kinase
HPY12_07940	COG3437	response regulator, receiver
HPY12_07940	COG2770	Histidine kinase
HPY12_07945	COG1448	Aminotransferase
HPY12_07960	COG0840	transmembrane signaling receptor activity
HPY12_07965	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY12_07970	COG2943	transferase activity, transferring hexosyl groups
HPY12_07975	COG1609	Transcriptional regulator
HPY12_07980	COG3394	polysaccharide catabolic process
HPY12_07985	COG1486	melibiose metabolic process
HPY12_07990	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPY12_08000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPY12_08005	COG0726	polysaccharide deacetylase
HPY12_08010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY12_08040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY12_08055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY12_08060	COG3108	Peptidase M15
HPY12_08090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY12_08100	COG2814	Major facilitator Superfamily
HPY12_08120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY12_08125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY12_08130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY12_08175	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY12_08180	COG4139	cobalamin transport
HPY12_08185	COG2988	succinylglutamate desuccinylase activity
HPY12_08200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY12_08205	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY12_08210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY12_08225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY12_08390	COG1484	DNA-dependent DNA replication
HPY12_08460	COG0582	viral genome integration into host DNA
HPY12_08465	COG2925	Exonuclease
HPY12_08470	COG1380	Effector of murein hydrolase LrgA
HPY12_08475	COG1346	cytolysis
HPY12_08505	COG0776	regulation of translation
HPY12_08510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY12_08510	COG0072	phenylalanine-tRNA ligase activity
HPY12_08515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY12_08555	COG0322	excinuclease ABC activity
HPY12_08560	COG2197	response regulator
HPY12_08565	COG0417	DNA replication proofreading
HPY12_08570	COG5001	Diguanylate cyclase
HPY12_08580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY12_08585	COG3099	Belongs to the UPF0263 family
HPY12_08600	COG1228	amidohydrolase
HPY12_08605	COG0010	Belongs to the arginase family
HPY12_08610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY12_08615	COG2986	histidine ammonia-lyase
HPY12_08635	COG0277	FAD linked oxidase domain protein
HPY12_08635	COG0247	lactate metabolic process
HPY12_08650	COG2885	chlorophyll binding
HPY12_08670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY12_08680	COG0281	malic enzyme
HPY12_08690	COG2949	membrane
HPY12_08700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY12_08710	COG0492	ferredoxin-NADP+ reductase activity
HPY12_08715	COG4988	ABC transporter
HPY12_08720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY12_08725	COG1187	pseudouridine synthase activity
HPY12_08730	COG0009	L-threonylcarbamoyladenylate synthase
HPY12_08735	COG0613	PHP domain protein
HPY12_08745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY12_08750	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY12_08755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY12_08760	COG0135	phosphoribosylanthranilate isomerase activity
HPY12_08760	COG0134	indole-3-glycerol-phosphate synthase activity
HPY12_08765	COG0133	tryptophan synthase activity
HPY12_08770	COG0159	tryptophan synthase activity
HPY12_08780	COG1435	thymidine kinase activity
HPY12_08785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY12_08790	COG1801	Protein of unknown function DUF72
HPY12_08795	COG4106	trans-aconitate 2-methyltransferase activity
HPY12_08800	COG0500	methyltransferase
HPY12_08805	COG0189	ligase activity
HPY12_08805	COG4067	protein conserved in archaea
HPY12_08820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY12_08830	COG3852	Histidine kinase
HPY12_08845	COG3070	regulator of competence-specific genes
HPY12_08855	COG2431	L-lysine efflux transmembrane transporter activity
HPY12_08865	COG0076	glutamate decarboxylase activity
HPY12_08870	COG1737	Transcriptional regulator
HPY12_08875	COG1012	belongs to the aldehyde dehydrogenase family
HPY12_08875	COG1454	alcohol dehydrogenase
HPY12_08880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY12_08885	COG2985	domain, Protein
HPY12_08885	COG3273	potassium ion transport
HPY12_08890	COG0542	response to heat
HPY12_08895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY12_08900	COG1278	Cold shock
HPY12_08910	COG1187	pseudouridine synthase activity
HPY12_08915	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY12_08915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY12_08920	COG0107	imidazoleglycerol-phosphate synthase activity
HPY12_08925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY12_08930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY12_08935	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY12_08935	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY12_08940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY12_08945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY12_08950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY12_08955	COG1757	Na H antiporter
HPY12_08960	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY12_08965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY12_08970	COG0482	sulfurtransferase activity
HPY12_08975	COG2915	High frequency lysogenization protein hflD homolog
HPY12_08980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY12_09000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY12_09015	COG0300	oxidoreductase activity
HPY12_09025	COG0501	Belongs to the peptidase M48B family
HPY12_09035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY12_09040	COG2226	methyltransferase
HPY12_09045	COG0156	8-amino-7-oxononanoate synthase activity
HPY12_09050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY12_09060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY12_09065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY12_09070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY12_09080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY12_09085	COG2199	diguanylate cyclase activity
HPY12_09085	COG2203	Gaf domain
HPY12_09095	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY12_09105	COG4628	conserved protein (DUF2132)
HPY12_09110	COG3092	negative regulation of chromosome organization
HPY12_09115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY12_09120	COG0857	belongs to the CobB CobQ family
HPY12_09120	COG0280	phosphate acetyltransferase
HPY12_09125	COG0435	Glutathione S-transferase
HPY12_09130	COG4608	Belongs to the ABC transporter superfamily
HPY12_09135	COG0444	Belongs to the ABC transporter superfamily
HPY12_09140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY12_09145	COG0601	transmembrane transport
HPY12_09165	COG2204	response regulator
HPY12_09170	COG3300	MHYT domain
HPY12_09170	COG5001	Diguanylate cyclase
HPY12_09175	COG4191	Histidine kinase
HPY12_09180	COG5002	protein histidine kinase activity
HPY12_09190	COG2201	protein-glutamate methylesterase activity
HPY12_09205	COG0009	L-threonylcarbamoyladenylate synthase
HPY12_09220	COG1881	PFAM PEBP family protein
HPY12_09245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY12_09250	COG0640	Transcriptional regulator
HPY12_09260	COG3706	GGDEF domain
HPY12_09280	COG1946	Acyl-CoA thioesterase
HPY12_09285	COG1522	sequence-specific DNA binding
HPY12_09295	COG0616	signal peptide processing
HPY12_09300	COG1028	Short-chain dehydrogenase reductase Sdr
HPY12_09305	COG2983	Belongs to the UPF0260 family
HPY12_09315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY12_09320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY12_09330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY12_09335	COG2832	Protein of unknown function (DUF454)
HPY12_09340	COG0745	RESPONSE REGULATOR receiver
HPY12_09345	COG0583	DNA-binding transcription factor activity
HPY12_09350	COG0778	Nitroreductase
HPY12_09355	COG1024	Enoyl-CoA hydratase
HPY12_09355	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY12_09360	COG0183	Belongs to the thiolase family
HPY12_09375	COG2067	long-chain fatty acid transport protein
HPY12_09385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY12_09390	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY12_09395	COG2801	Transposase and inactivated derivatives
HPY12_09400	COG2982	Protein involved in outer membrane biogenesis
HPY12_09405	COG0572	uridine kinase
HPY12_09410	COG0489	protein tyrosine kinase activity
HPY12_09415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY12_09415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY12_09425	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY12_09435	COG0617	tRNA 3'-terminal CCA addition
HPY12_09435	COG0517	IMP dehydrogenase activity
HPY12_09435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY12_09440	COG2199	diguanylate cyclase activity
HPY12_09445	COG0314	molybdopterin synthase activity
HPY12_09450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY12_09455	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY12_09460	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY12_09465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY12_09470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY12_09475	COG2198	Histidine kinase
HPY12_09480	COG2204	response regulator
HPY12_09485	COG0556	nucleotide-excision repair
HPY12_09495	COG0582	viral genome integration into host DNA
HPY12_09500	COG2801	Transposase and inactivated derivatives
HPY12_09525	COG2003	Belongs to the UPF0758 family
HPY12_09565	COG2831	hemolysin activation secretion protein
HPY12_09595	COG4657	Part of a membrane complex involved in electron transport
HPY12_09600	COG2878	Part of a membrane complex involved in electron transport
HPY12_09605	COG4656	Part of a membrane complex involved in electron transport
HPY12_09620	COG4660	Part of a membrane complex involved in electron transport
HPY12_09625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY12_09630	COG0346	lactoylglutathione lyase activity
HPY12_09650	COG2056	Na+-H+ antiporter family
HPY12_09655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY12_09660	COG1286	toxin biosynthetic process
HPY12_09665	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY12_09670	COG0285	dihydrofolate synthase activity
HPY12_09675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY12_09680	COG0101	tRNA pseudouridine synthase activity
HPY12_09695	COG1263	PTS System
HPY12_09695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY12_09695	COG2190	(PTS) system
HPY12_09700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY12_09705	COG1940	carbohydrate kinase activity
HPY12_09705	COG1846	Transcriptional regulator
HPY12_09710	COG4651	solute:proton antiporter activity
HPY12_09710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY12_09715	COG0367	asparagine synthase
HPY12_09730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY12_09735	COG0563	adenylate kinase activity
HPY12_09740	COG0326	Molecular chaperone. Has ATPase activity
HPY12_09745	COG3710	Transcriptional regulator
HPY12_09760	COG0622	Phosphoesterase
HPY12_09765	COG1090	epimerase
HPY12_09770	COG0300	oxidoreductase activity
HPY12_09775	COG3118	belongs to the thioredoxin family
HPY12_09780	COG0330	HflC and HflK could
HPY12_09785	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY12_09790	COG0789	Transcriptional regulator
HPY12_09805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY12_09810	COG3115	cell septum assembly
HPY12_09815	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY12_09825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_09835	COG2190	(PTS) system
HPY12_09840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY12_09845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY12_09850	COG1702	phosphate starvation-inducible protein PhoH
HPY12_09855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY12_09860	COG4535	Mg2 and Co2 transporter CorC
HPY12_09865	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY12_09870	COG2888	peptidyl-tyrosine sulfation
HPY12_09875	COG0495	leucyl-tRNA aminoacylation
HPY12_09880	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY12_09910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY12_09915	COG1686	Belongs to the peptidase S11 family
HPY12_09920	COG2921	Belongs to the UPF0250 family
HPY12_09925	COG0321	lipoyl(octanoyl) transferase activity
HPY12_09930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY12_09940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY12_09965	COG1596	polysaccharide export
HPY12_09975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY12_10005	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY12_10015	COG0438	transferase activity, transferring glycosyl groups
HPY12_10040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY12_10045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY12_10050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY12_10055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY12_10085	COG0366	Alpha amylase catalytic
HPY12_10090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY12_10090	COG1263	PTS System
HPY12_10095	COG1609	Transcriptional regulator
HPY12_10100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY12_10105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY12_10110	COG2011	ABC-type metal ion transport system permease component
HPY12_10115	COG1464	Belongs to the NlpA lipoprotein family
HPY12_10120	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY12_10130	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY12_10130	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY12_10140	COG3706	GGDEF domain
HPY12_10145	COG1611	Belongs to the LOG family
HPY12_10150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY12_10155	COG2363	Small membrane protein
HPY12_10160	COG0583	DNA-binding transcription factor activity
HPY12_10165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY12_10165	COG0301	tRNA thio-modification
HPY12_10175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY12_10180	COG1722	exodeoxyribonuclease VII activity
HPY12_10185	COG0142	geranyltranstransferase activity
HPY12_10190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY12_10195	COG0564	pseudouridine synthase activity
HPY12_10200	COG3098	single-species biofilm formation
HPY12_10215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY12_10225	COG1671	Belongs to the UPF0178 family
HPY12_10235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY12_10240	COG0254	rRNA binding
HPY12_10245	COG1720	tRNA m6t6A37 methyltransferase activity
HPY12_10250	COG0442	prolyl-tRNA aminoacylation
HPY12_10270	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY12_10270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY12_10280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY12_10290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY12_10320	COG0484	heat shock protein binding
HPY12_10325	COG0443	Heat shock 70 kDa protein
HPY12_10330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY12_10335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY12_10340	COG0497	DNA recombination
HPY12_10345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY12_10350	COG2914	Belongs to the UPF0125 (RnfH) family
HPY12_10355	COG2867	negative regulation of translational initiation
HPY12_10360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY12_10385	COG2801	Transposase and inactivated derivatives
HPY12_10395	COG1104	cysteine desulfurase activity
HPY12_10460	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY12_10465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY12_10470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY12_10490	COG3051	citrate lyase alpha subunit
HPY12_10495	COG2301	Belongs to the HpcH HpaI aldolase family
HPY12_10505	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY12_10515	COG3630	sodium ion export across plasma membrane
HPY12_10520	COG5016	pyruvate
HPY12_10520	COG0511	ligase activity, forming carbon-carbon bonds
HPY12_10525	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY12_10535	COG4565	transcriptional regulatory protein
HPY12_10550	COG0583	DNA-binding transcription factor activity
HPY12_10560	COG1115	amino acid carrier protein
HPY12_10565	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY12_10570	COG0583	DNA-binding transcription factor activity
HPY12_10580	COG1120	ATPase activity
HPY12_10585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY12_10590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY12_10595	COG4592	Periplasmic binding protein
HPY12_10605	COG1028	Short-chain dehydrogenase reductase Sdr
HPY12_10610	COG1169	isochorismate synthase
HPY12_10615	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY12_10620	COG1535	isochorismatase
HPY12_10620	COG3433	isochorismatase activity
HPY12_10625	COG1584	GPR1 FUN34 yaaH family protein
HPY12_10635	COG0519	Catalyzes the synthesis of GMP from XMP
HPY12_10635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY12_10640	COG0517	IMP dehydrogenase activity
HPY12_10640	COG0516	GMP reductase activity
HPY12_10645	COG1570	exodeoxyribonuclease VII activity
HPY12_10660	COG1160	GTP binding
HPY12_10665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY12_10670	COG2976	Protein conserved in bacteria
HPY12_10675	COG0124	histidyl-tRNA synthetase
HPY12_10680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY12_10685	COG1426	Protein conserved in bacteria
HPY12_10695	COG0105	UTP biosynthetic process
HPY12_10700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY12_10705	COG2975	iron-sulfur cluster assembly
HPY12_10710	COG0633	Ferredoxin
HPY12_10730	COG0822	iron-sulfur transferase activity
HPY12_10740	COG1959	2 iron, 2 sulfur cluster binding
HPY12_10750	COG0483	inositol monophosphate 1-phosphatase activity
HPY12_10755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY12_10760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY12_10765	COG1862	Preprotein translocase
HPY12_10775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY12_10780	COG0517	IMP dehydrogenase activity
HPY12_10790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY12_10795	COG0583	DNA-binding transcription factor activity
HPY12_10800	COG0450	alkyl hydroperoxide reductase
HPY12_10805	COG3142	Participates in the control of copper homeostasis
HPY12_10820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY12_10825	COG0581	inorganic phosphate transmembrane transporter activity
HPY12_10835	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY12_10840	COG0248	Ppx GppA phosphatase
HPY12_10850	COG5002	protein histidine kinase activity
HPY12_10855	COG0745	RESPONSE REGULATOR receiver
HPY12_10870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY12_10910	COG0542	response to heat
HPY12_10920	COG0564	pseudouridine synthase activity
HPY12_10925	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY12_10930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY12_10935	COG0077	Prephenate dehydratase
HPY12_10935	COG1605	Chorismate mutase
HPY12_10940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY12_10945	COG5001	Diguanylate cyclase
HPY12_10955	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY12_10965	COG0488	(ABC) transporter
HPY12_10975	COG1605	Chorismate mutase
HPY12_10975	COG0287	Prephenate dehydrogenase
HPY12_10980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY12_10985	COG3275	phosphorelay sensor kinase activity
HPY12_10990	COG3279	Response regulator of the LytR AlgR family
HPY12_11000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY12_11005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY12_11020	COG1966	Carbon starvation protein
HPY12_11030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY12_11035	COG1047	Peptidyl-prolyl cis-trans
HPY12_11040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY12_11050	COG0196	riboflavin kinase activity
HPY12_11055	COG0728	peptidoglycan biosynthetic process
HPY12_11060	COG0268	Binds directly to 16S ribosomal RNA
HPY12_11065	COG0640	Transcriptional regulator
HPY12_11070	COG0583	DNA-binding transcription factor activity
HPY12_11075	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY12_11080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPY12_11085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY12_11090	COG0730	response to heat
HPY12_11095	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY12_11100	COG0494	nUDIX hydrolase
HPY12_11105	COG3066	DNA modification
HPY12_11110	COG0667	Aldo Keto reductase
HPY12_11120	COG2204	response regulator
HPY12_11125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY12_11145	COG0513	Belongs to the DEAD box helicase family
HPY12_11170	COG3153	acetyltransferase
HPY12_11175	COG3154	lipid carrier protein
HPY12_11185	COG0826	peptidase U32
HPY12_11190	COG0826	peptidase U32
HPY12_11215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY12_11225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY12_11230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY12_11235	COG0195	Participates in both transcription termination and antitermination
HPY12_11240	COG0779	Required for maturation of 30S ribosomal subunits
HPY12_11255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY12_11265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY12_11270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY12_11275	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY12_11280	COG1534	Rna-binding protein
HPY12_11285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY12_11290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY12_11295	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY12_11305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY12_11310	COG0739	heme binding
HPY12_11325	COG0316	Belongs to the HesB IscA family
HPY12_11330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY12_11335	COG0628	permease
HPY12_11340	COG2813	Specifically methylates the guanine in position
HPY12_11345	COG2205	protein histidine kinase activity
HPY12_11345	COG0784	Response regulator, receiver
HPY12_11350	COG0747	negative chemotaxis
HPY12_11360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY12_11365	COG0444	Belongs to the ABC transporter superfamily
HPY12_11370	COG4608	Belongs to the ABC transporter superfamily
HPY12_11380	COG2971	BadF BadG BcrA BcrD
HPY12_11395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY12_11400	COG3842	ATPase activity
HPY12_11410	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY12_11415	COG0004	ammonium transporteR
HPY12_11420	COG0347	Belongs to the P(II) protein family
HPY12_11425	COG3112	Uncharacterised protein family (UPF0231)
HPY12_11430	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY12_11435	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY12_11440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY12_11445	COG1643	Atp-dependent helicase
HPY12_11455	COG1489	DNA binding
HPY12_11465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY12_11475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY12_11480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY12_11485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY12_11490	COG0842	Transport permease protein
HPY12_11495	COG1131	(ABC) transporter
HPY12_11500	COG0659	secondary active sulfate transmembrane transporter activity
HPY12_11505	COG0288	reversible hydration of carbon dioxide
HPY12_11520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY12_11525	COG3107	peptidoglycan biosynthetic process
HPY12_11530	COG0792	nuclease activity
HPY12_11535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY12_11540	COG2823	Periplasmic or secreted lipoprotein
HPY12_11545	COG2969	positive regulation of protein catabolic process
HPY12_11550	COG0625	glutathione transferase activity
HPY12_11555	COG2857	Cytochrome c1
HPY12_11560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY12_11565	COG0723	plastoquinol--plastocyanin reductase activity
HPY12_11570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY12_11575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY12_11580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY12_11590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY12_11595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY12_11600	COG0335	large ribosomal subunit rRNA binding
HPY12_11605	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY12_11610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY12_11615	COG0228	four-way junction DNA binding
HPY12_11620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY12_11625	COG4137	Cytochrome C assembly protein
HPY12_11630	COG4536	flavin adenine dinucleotide binding
HPY12_11635	COG1854	S-ribosylhomocysteine lyase activity
HPY12_11640	COG2918	glutathione biosynthetic process
HPY12_11645	COG0612	Peptidase, M16
HPY12_11650	COG1238	metal cluster binding
HPY12_11660	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY12_11665	COG5016	pyruvate
HPY12_11665	COG0511	ligase activity, forming carbon-carbon bonds
HPY12_11670	COG3630	sodium ion export across plasma membrane
HPY12_11715	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY12_11720	COG0527	aspartate kinase activity
HPY12_11725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY12_11730	COG2137	regulation of response to DNA damage stimulus
HPY12_11735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY12_11745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY12_11750	COG4208	sulfate ABC transporter
HPY12_11775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY12_11785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY12_11790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY12_11795	COG0585	pseudouridine synthase activity
HPY12_11800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY12_11805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY12_11810	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY12_11815	COG1968	undecaprenyl-diphosphatase activity
HPY12_11820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY12_11825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY12_11830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY12_11840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY12_11845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY12_11850	COG1610	YqeY-like protein
HPY12_11855	COG0358	DNA primase activity
HPY12_11875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY12_11880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY12_11885	COG1349	DNA-binding transcription factor activity
HPY12_11905	COG1279	arginine transmembrane transporter activity
HPY12_11910	COG0668	transmembrane transport
HPY12_11915	COG0191	fructose-bisphosphate aldolase activity
HPY12_11925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY12_11930	COG4771	TonB-dependent receptor
HPY12_11935	COG0583	DNA-binding transcription factor activity
HPY12_11940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY12_11945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY12_11950	COG3091	SprT-like family
HPY12_11955	COG2356	endonuclease I
HPY12_11960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY12_11965	COG0189	ligase activity
HPY12_11970	COG1678	Uncharacterized ACR, COG1678
HPY12_11975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY12_11980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY12_12000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY12_12005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY12_12010	COG0762	integral membrane protein
HPY12_12025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY12_12030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY12_12035	COG2066	Belongs to the glutaminase family
HPY12_12040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY12_12045	COG1194	a g-specific adenine glycosylase
HPY12_12050	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY12_12055	COG0741	lytic transglycosylase activity
HPY12_12110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY12_12115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY12_12120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY12_12125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY12_12130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY12_12135	COG2967	ApaG domain
HPY12_12140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY12_12150	COG3610	response to peptide
HPY12_12155	COG2966	Psort location CytoplasmicMembrane, score
HPY12_12160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY12_12165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY12_12170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY12_12175	COG0142	geranyltranstransferase activity
HPY12_12180	COG0531	amino acid
HPY12_12185	COG0039	L-malate dehydrogenase activity
HPY12_12190	COG1438	arginine binding
HPY12_12195	COG2358	TRAP transporter, solute receptor (TAXI family
HPY12_12205	COG0589	response to stress
HPY12_12225	COG2235	arginine
HPY12_12230	COG0312	modulator of DNA gyrase
HPY12_12235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY12_12240	COG3164	Protein of unknown function
HPY12_12245	COG1530	ribonuclease E activity
HPY12_12250	COG0424	maF-like protein
HPY12_12255	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY12_12260	COG1792	Involved in formation and maintenance of cell shape
HPY12_12265	COG1077	Cell shape determining protein MreB Mrl
HPY12_12310	COG1459	type II secretion system
HPY12_12325	COG3267	Type II secretory pathway component ExeA
HPY12_12325	COG3409	Peptidoglycan-binding domain 1 protein
HPY12_12350	COG2199	diguanylate cyclase activity
HPY12_12350	COG2200	EAL domain
HPY12_12355	COG0629	single-stranded DNA binding
HPY12_12370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY12_12380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY12_12385	COG0527	aspartate kinase activity
HPY12_12390	COG1410	methionine synthase
HPY12_12390	COG0646	methionine synthase
HPY12_12430	COG0175	sulfate reduction
HPY12_12435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPY12_12440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY12_12465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY12_12470	COG0735	belongs to the Fur family
HPY12_12485	COG0166	Belongs to the GPI family
HPY12_12520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPY12_12565	COG0432	Pfam Uncharacterised protein family UPF0047
HPY12_12575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY12_12590	COG0359	binds to the 23S rRNA
HPY12_12595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY12_12600	COG2965	DNA replication, synthesis of RNA primer
HPY12_12605	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY12_12615	COG2906	2 iron, 2 sulfur cluster binding
HPY12_12620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY12_12625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY12_12630	COG0049	tRNA binding
HPY12_12645	COG2923	Belongs to the DsrF TusC family
HPY12_12650	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY12_12655	COG2964	Protein conserved in bacteria
HPY12_12660	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY12_12670	COG2900	Belongs to the SlyX family
HPY12_12675	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY12_12680	COG0330	HflC and HflK could
HPY12_12685	COG0330	HflC and HflK could
HPY12_12690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY12_12695	COG1923	regulation of RNA biosynthetic process
HPY12_12700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY12_12705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY12_12715	COG0802	atpase or kinase
HPY12_12720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY12_12770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY12_12775	COG1162	GTPase activity
HPY12_12780	COG0688	phosphatidylethanolamine metabolic process
HPY12_12785	COG0471	metal ion transport
HPY12_12795	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY12_12800	COG4942	peptidase
HPY12_12815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY12_12820	COG2816	NAD+ diphosphatase activity
HPY12_12825	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY12_12830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY12_12835	COG0085	RNA polymerase activity
HPY12_12840	COG0222	ribosome binding
HPY12_12845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY12_12855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY12_12860	COG0250	Participates in transcription elongation, termination and antitermination
HPY12_12865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY12_12870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY12_12895	COG1072	(Pantothenic acid kinase))
HPY12_12905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY12_12915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY12_12990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY12_13005	COG3118	belongs to the thioredoxin family
HPY12_13010	COG0513	Belongs to the DEAD box helicase family
HPY12_13015	COG0248	Ppx GppA phosphatase
HPY12_13020	COG2205	protein histidine kinase activity
HPY12_13020	COG2202	Pas domain
HPY12_13025	COG2814	Major facilitator Superfamily
HPY12_13040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY12_13045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY12_13050	COG0511	ligase activity, forming carbon-carbon bonds
HPY12_13060	COG2264	protein methyltransferase activity
HPY12_13065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY12_13070	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY12_13085	COG1609	Transcriptional regulator
HPY12_13090	COG0129	dihydroxy-acid dehydratase activity
HPY12_13095	COG3265	gluconokinase activity
HPY12_13105	COG0800	Aldolase
HPY12_13125	COG0840	transmembrane signaling receptor activity
HPY12_13130	COG1982	Orn Lys Arg decarboxylase major
HPY12_13135	COG0531	amino acid
HPY12_13140	COG3710	Transcriptional regulator
HPY12_13145	COG0789	Transcriptional regulator
HPY12_13160	COG0151	Belongs to the GarS family
HPY12_13170	COG0776	regulation of translation
HPY12_13175	COG1253	flavin adenine dinucleotide binding
HPY12_13180	COG1940	carbohydrate kinase activity
HPY12_13190	COG3068	Protein conserved in bacteria
HPY12_13200	COG1573	uracil-dna glycosylase
HPY12_13205	COG0668	transmembrane transport
HPY12_13210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY12_13240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY12_13245	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPY12_13255	COG0463	Glycosyl transferase, family 2
HPY12_13270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY12_13275	COG0318	PFAM AMP-dependent synthetase and ligase
HPY12_13290	COG1028	Short-chain dehydrogenase reductase Sdr
HPY12_13300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY12_13345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY12_13350	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HPY12_13350	COG0662	Cupin 2, conserved barrel domain protein
HPY12_13355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY12_13390	COG1519	Transferase
HPY12_13420	COG3642	lipopolysaccharide core region biosynthetic process
HPY12_13425	COG0859	PFAM glycosyl transferase family 9
HPY12_13430	COG0463	Glycosyl transferase, family 2
HPY12_13435	COG0859	PFAM glycosyl transferase family 9
HPY12_13440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY12_13445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY12_13455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY12_13460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY12_13465	COG2003	Belongs to the UPF0758 family
HPY12_13475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY12_13485	COG1309	transcriptional regulator
HPY12_13490	COG1560	Kdo2-lipid A biosynthetic process
HPY12_13495	COG1560	Kdo2-lipid A biosynthetic process
HPY12_13500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY12_13505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY12_13510	COG1561	YicC-like family, N-terminal region
HPY12_13515	COG2862	Uncharacterized protein family, UPF0114
HPY12_13520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY12_13520	COG1263	PTS System
HPY12_13525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY12_13545	COG1120	ATPase activity
HPY12_13550	COG4774	siderophore transport
HPY12_13555	COG1132	(ABC) transporter
HPY12_13570	COG0514	ATP-dependent DNA helicase (RecQ)
HPY12_13575	COG2962	Rard protein
HPY12_13580	COG0405	Gamma-glutamyltransferase
HPY12_13590	COG1280	lysine exporter protein (LysE YggA)
HPY12_13595	COG0210	DNA helicase
HPY12_13605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY12_13610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY12_13620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY12_13630	COG0747	negative chemotaxis
HPY12_13680	COG1309	transcriptional regulator
HPY12_13685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY12_13690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY12_13695	COG2960	long-chain fatty acid transporting porin activity
HPY12_13700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY12_13705	COG0583	DNA-binding transcription factor activity
HPY12_13775	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY12_13780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY12_13785	COG1739	Uncharacterized protein family UPF0029
HPY12_13790	COG1024	Enoyl-CoA hydratase
HPY12_13790	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY12_13795	COG0183	Belongs to the thiolase family
HPY12_13800	COG0583	DNA-binding transcription factor activity
HPY12_13805	COG2814	Major facilitator Superfamily
HPY12_13815	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY12_13820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY12_13825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY12_13830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY12_13835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY12_13840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY12_13850	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY12_13855	COG3312	ion transport
HPY12_13860	COG1475	DNA binding
HPY12_13865	COG1192	Involved in chromosome partitioning
HPY12_13870	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY12_13875	COG0445	tRNA wobble uridine modification
HPY12_13880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY12_13885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY12_13890	COG0706	membrane insertase activity
HPY12_13900	COG0594	ribonuclease P activity
HPY12_13905	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY12_13910	COG1126	abc transporter atp-binding protein
HPY12_13955	COG0217	transcriptional regulatory protein
HPY12_13960	COG2084	Dehydrogenase
HPY12_13975	COG2909	trisaccharide binding
HPY12_13980	COG0058	SHG alpha-glucan phosphorylase activity
HPY12_13985	COG1640	4-alpha-glucanotransferase
HPY12_13990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY12_14000	COG3501	Rhs element vgr protein
HPY12_14035	COG0471	metal ion transport
HPY12_14040	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY12_14080	COG0671	phosphoesterase, PA-phosphatase related
HPY12_14085	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY12_14095	COG1999	signal sequence binding
HPY12_14110	COG0786	glutamate:sodium symporter activity
HPY12_14130	COG1566	PFAM secretion protein HlyD family protein
HPY12_14140	COG3706	GGDEF domain
HPY12_14155	COG0813	purine-nucleoside phosphorylase activity
HPY12_14160	COG3272	Protein of unknown function (DUF1722)
HPY12_14170	COG0415	Belongs to the DNA photolyase family
HPY12_14175	COG1376	ErfK ybiS ycfS ynhG family protein
HPY12_14175	COG1388	LysM domain
HPY12_14185	COG0513	Belongs to the DEAD box helicase family
HPY12_14190	COG1770	oligopeptidase
HPY12_14220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY12_14225	COG0573	inorganic phosphate transmembrane transporter activity
HPY12_14230	COG0581	inorganic phosphate transmembrane transporter activity
HPY12_14235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY12_14260	COG0659	secondary active sulfate transmembrane transporter activity
HPY12_14270	COG0739	heme binding
HPY12_14275	COG3300	MHYT domain
HPY12_14275	COG5001	Diguanylate cyclase
HPY12_14280	COG0583	DNA-binding transcription factor activity
HPY12_14285	COG2814	Major facilitator Superfamily
HPY12_14305	COG1301	dicarboxylic acid transport
HPY12_14315	COG1342	Belongs to the UPF0251 family
HPY12_14350	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY12_14355	COG0673	inositol 2-dehydrogenase activity
HPY12_14365	COG2771	luxR family
HPY12_14365	COG2200	EAL domain
HPY12_14370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY12_14380	COG0564	pseudouridine synthase activity
HPY12_14470	COG3501	Rhs element vgr protein
HPY12_14485	COG1869	D-ribose catabolic process
HPY12_14490	COG1129	ABC transporter
HPY12_14495	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY12_14500	COG1879	ABC-type sugar transport system periplasmic component
HPY12_14505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY12_14510	COG1609	Transcriptional regulator
HPY12_14520	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY12_14530	COG0584	glycerophosphoryl diester phosphodiesterase
HPY12_14535	COG2271	Major facilitator Superfamily
HPY12_14570	COG0579	oxidoreductase
HPY12_14580	COG0242	peptide deformylase activity
HPY12_14595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_14600	COG1609	Transcriptional regulator
HPY12_14610	COG1320	monovalent cation:proton antiporter activity
HPY12_14615	COG2212	antiporter activity
HPY12_14635	COG2111	Na H antiporter
HPY12_14635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY12_14645	COG0589	response to stress
HPY12_14650	COG0814	amino acid
HPY12_14670	COG3530	Putative quorum-sensing-regulated virulence factor
HPY12_14680	COG5002	protein histidine kinase activity
HPY12_14680	COG5001	Diguanylate cyclase
HPY12_14685	COG1278	Cold shock
HPY12_14700	COG2304	oxidoreductase activity
HPY12_14720	COG0714	Associated with various cellular activities
HPY12_14725	COG0840	transmembrane signaling receptor activity
HPY12_14740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY12_14745	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY12_14755	COG3604	Transcriptional regulator
HPY12_14760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY12_14760	COG1017	nitric oxide dioxygenase activity
HPY12_14765	COG1278	Cold shock
HPY12_14770	COG3036	rescue of stalled ribosome
HPY12_14795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY12_14795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY12_14800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY12_14810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY12_14820	COG0516	GMP reductase activity
HPY12_14830	COG0583	DNA-binding transcription factor activity
HPY12_14835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY12_14840	COG0513	Belongs to the DEAD box helicase family
HPY12_14845	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY12_14855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY12_14865	COG4191	Histidine kinase
HPY12_14865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY12_14875	COG1757	Na H antiporter
HPY12_14880	COG2814	Major facilitator Superfamily
HPY12_14890	COG3706	GGDEF domain
HPY12_14895	COG3240	lipase activity
HPY12_14905	COG0840	transmembrane signaling receptor activity
HPY12_14910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY12_14915	COG5380	lipid catabolic process
HPY12_14940	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY12_14945	COG4605	iron ion homeostasis
HPY12_14950	COG4604	ABC transporter, ATP-binding protein
HPY12_14955	COG2207	Transcriptional regulator
HPY12_14970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY12_14990	COG0745	RESPONSE REGULATOR receiver
HPY12_15000	COG3623	hexulose-6-phosphate isomerase
HPY12_15005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY12_15010	COG0561	phosphatase activity
HPY12_15045	COG0366	Alpha amylase catalytic
HPY12_15065	COG0745	RESPONSE REGULATOR receiver
HPY12_15070	COG5002	protein histidine kinase activity
HPY12_15110	COG2814	Major facilitator Superfamily
HPY12_15125	COG1686	Belongs to the peptidase S11 family
HPY12_15145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY12_15145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY12_15150	COG0509	glycine decarboxylation via glycine cleavage system
HPY12_15155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY12_15165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY12_15180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY12_15185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY12_15195	COG4977	sequence-specific DNA binding
HPY12_15225	COG0384	phenazine biosynthesis protein PhzF
HPY12_15285	COG0454	-acetyltransferase
HPY12_15320	COG3549	Plasmid maintenance system killer
HPY12_15325	COG3093	addiction module antidote protein HigA
HPY12_15395	COG0494	nUDIX hydrolase
HPY12_15400	COG0456	acetyltransferase
HPY12_15405	COG3040	lipid binding
HPY12_15410	COG3040	lipid binding
HPY12_15420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY12_15440	COG0384	phenazine biosynthesis protein PhzF
HPY12_15455	COG0456	acetyltransferase
HPY12_15480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY12_15520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY12_15590	COG3549	Plasmid maintenance system killer
HPY12_15595	COG3093	addiction module antidote protein HigA
HPY12_15640	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY12_15670	COG1418	mRNA catabolic process
HPY12_15690	COG0346	lactoylglutathione lyase activity
HPY12_15875	COG0346	lactoylglutathione lyase activity
HPY12_15895	COG1328	CTP reductase activity
HPY12_15900	COG0602	queuosine metabolic process
HPY12_15910	COG4067	protein conserved in archaea
HPY12_15910	COG0189	ligase activity
HPY12_15915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY12_15915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY12_15915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY12_15920	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY12_15925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_15925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_15930	COG1609	Transcriptional regulator
HPY12_15935	COG0420	3'-5' exonuclease activity
HPY12_15940	COG0419	ATPase involved in DNA repair
HPY12_15945	COG2205	protein histidine kinase activity
HPY12_15945	COG0784	Response regulator, receiver
HPY12_15950	COG0156	8-amino-7-oxononanoate synthase activity
HPY12_15965	COG0523	cobalamin synthesis protein
HPY12_15975	COG3158	transport of potassium into the cell
HPY12_15980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY12_15980	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY12_15980	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY12_15980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY12_15985	COG2205	protein histidine kinase activity
HPY12_15990	COG0745	RESPONSE REGULATOR receiver
HPY12_15995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY12_16000	COG0586	Pfam SNARE associated Golgi protein
HPY12_16010	COG2200	EAL domain
HPY12_16020	COG3038	cytochrome b561
HPY12_16030	COG2116	formate transmembrane transporter activity
HPY12_16035	COG0583	DNA-binding transcription factor activity
HPY12_16045	COG3593	DNA synthesis involved in DNA repair
HPY12_16050	COG0737	Belongs to the 5'-nucleotidase family
HPY12_16065	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY12_16095	COG3706	GGDEF domain
HPY12_16115	COG3706	GGDEF domain
HPY12_16130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY12_16135	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY12_16145	COG0745	RESPONSE REGULATOR receiver
HPY12_16160	COG3140	Belongs to the UPF0181 family
HPY12_16230	COG0023	Translation Initiation Factor
HPY12_16250	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY12_16250	COG1042	CoA-binding domain protein
HPY12_16250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY12_16255	COG0583	DNA-binding transcription factor activity
HPY12_16260	COG4771	TonB-dependent receptor
HPY12_16275	COG2050	protein possibly involved in aromatic compounds catabolism
HPY12_16295	COG0625	glutathione transferase activity
HPY12_16310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY12_16315	COG4172	Belongs to the ABC transporter superfamily
HPY12_16320	COG4239	(ABC) transporter, permease
HPY12_16325	COG4174	ABC transporter (Permease)
HPY12_16330	COG4166	transmembrane transport
HPY12_16355	COG3104	oligopeptide transport
HPY12_16375	COG3842	ATPase activity
HPY12_16380	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY12_16385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY12_16395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY12_16400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY12_16405	COG1011	Hydrolase
HPY12_16415	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY12_16420	COG1970	mechanosensitive ion channel activity
HPY12_16425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY12_16430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY12_16430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY12_16435	COG0302	gtp cyclohydrolase
HPY12_16445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY12_16455	COG2897	thiosulfate sulfurtransferase activity
HPY12_16470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY12_16500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY12_16525	COG0583	DNA-binding transcription factor activity
HPY12_16530	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY12_16555	COG2391	methyltransferase activity
HPY12_16570	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY12_16615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY12_16615	COG1263	PTS System
HPY12_16625	COG1621	beta-fructofuranosidase activity
HPY12_16630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY12_16635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY12_16650	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY12_16655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY12_16660	COG0840	transmembrane signaling receptor activity
HPY12_16665	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY12_16670	COG1760	l-serine dehydratase
HPY12_16690	COG1609	Transcriptional regulator
HPY12_16695	COG2197	response regulator
HPY12_16700	COG3850	Histidine kinase
HPY12_16705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY12_16715	COG0243	molybdopterin cofactor binding
HPY12_16735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY12_16740	COG2197	response regulator
HPY12_16745	COG3851	Histidine kinase
HPY12_16750	COG2271	Major facilitator Superfamily
HPY12_16755	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY12_16765	COG3842	ATPase activity
HPY12_16770	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY12_16780	COG0183	Belongs to the thiolase family
HPY12_16790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY12_16795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY12_16810	COG3706	GGDEF domain
HPY12_16815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY12_16825	COG1979	alcohol dehydrogenase
HPY12_16840	COG4191	Histidine kinase
HPY12_16850	COG2271	Major facilitator Superfamily
HPY12_16855	COG0469	pyruvate kinase activity
HPY12_16860	COG0784	Response regulator, receiver
HPY12_16860	COG2198	Histidine kinase
HPY12_16860	COG2205	protein histidine kinase activity
HPY12_16865	COG1879	ABC-type sugar transport system periplasmic component
HPY12_16870	COG1803	Methylglyoxal synthase
HPY12_16875	COG1335	isochorismatase
HPY12_16880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY12_16895	COG0210	DNA helicase
HPY12_16900	COG1289	transmembrane transporter activity
HPY12_16930	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY12_16935	COG4149	molybdate abc transporter
HPY12_16940	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY12_16945	COG1492	cobalamin metabolic process
HPY12_16950	COG1204	response to ionizing radiation
HPY12_16985	COG5002	protein histidine kinase activity
HPY12_16985	COG0784	Response regulator, receiver
HPY12_16990	COG1879	ABC-type sugar transport system periplasmic component
HPY12_17000	COG2827	Endonuclease containing a URI domain
HPY12_17005	COG3132	Protein of unknown function, DUF480
HPY12_17015	COG2926	Belongs to the UPF0265 family
HPY12_17025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY12_17030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY12_17035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY12_17045	COG0247	lactate metabolic process
HPY12_17050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY12_17055	COG3118	belongs to the thioredoxin family
HPY12_17080	COG4160	amino acid transport
HPY12_17085	COG4215	(ABC) transporter
HPY12_17090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY12_17095	COG1126	abc transporter atp-binding protein
HPY12_17105	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY12_17115	COG0494	nUDIX hydrolase
HPY12_17120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY12_17130	COG1309	transcriptional regulator
HPY12_17135	COG0513	Belongs to the DEAD box helicase family
HPY12_17140	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY12_17145	COG0814	amino acid
HPY12_17150	COG0840	transmembrane signaling receptor activity
HPY12_17155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY12_17160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY12_17170	COG1984	allophanate hydrolase subunit 2
HPY12_17185	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY12_17190	COG4181	ATPase activity
HPY12_17200	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY12_17205	COG5001	Diguanylate cyclase
HPY12_17205	COG1716	ATPase activity
HPY12_17215	COG0484	heat shock protein binding
HPY12_17230	COG0546	phosphoglycolate phosphatase activity
HPY12_17245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY12_17250	COG1368	sulfuric ester hydrolase activity
HPY12_17260	COG0513	Belongs to the DEAD box helicase family
HPY12_17275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY12_17285	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY12_17295	COG3227	Zinc metalloprotease (Elastase)
HPY12_17305	COG0010	Belongs to the arginase family
HPY12_17310	COG1166	arginine decarboxylase activity
HPY12_17320	COG2239	Acts as a magnesium transporter
HPY12_17325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY12_17330	COG0459	protein refolding
HPY12_17340	COG0527	aspartate kinase activity
HPY12_17345	COG0662	Cupin 2, conserved barrel domain protein
HPY12_17350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY12_17355	COG0456	acetyltransferase
HPY12_17360	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY12_17365	COG3186	Phenylalanine-4-hydroxylase
HPY12_17370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY12_17385	COG2264	protein methyltransferase activity
HPY12_17410	COG1253	flavin adenine dinucleotide binding
HPY12_17415	COG1765	OsmC-like protein
HPY12_17445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPY12_17450	COG0531	amino acid
HPY12_17455	COG3706	GGDEF domain
HPY12_17465	COG3279	Response regulator of the LytR AlgR family
HPY12_17470	COG3275	phosphorelay sensor kinase activity
HPY12_17485	COG1136	(ABC) transporter
HPY12_17485	COG0577	efflux transmembrane transporter activity
HPY12_17490	COG1136	(ABC) transporter
HPY12_17500	COG4989	oxidoreductase activity
HPY12_17505	COG0366	Alpha amylase catalytic
HPY12_17515	COG2067	long-chain fatty acid transport protein
HPY12_17520	COG2267	carboxylic ester hydrolase activity
HPY12_17530	COG3227	Zinc metalloprotease (Elastase)
HPY12_17535	COG3047	cAMP biosynthetic process
HPY12_17545	COG1686	Belongs to the peptidase S11 family
HPY12_17550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPY12_17555	COG1271	oxidase subunit
HPY12_17560	COG1294	oxidase, subunit
HPY12_17575	COG3048	D-serine ammonia-lyase activity
HPY12_17580	COG0583	DNA-binding transcription factor activity
HPY12_17625	COG1063	alcohol dehydrogenase
HPY12_17650	COG0346	lactoylglutathione lyase activity
HPY12_17675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY12_17680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY12_17685	COG0363	glucosamine-6-phosphate deaminase activity
HPY12_17690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY12_17715	COG1929	Belongs to the glycerate kinase type-1 family
HPY12_17720	COG2610	gluconate transmembrane transporter activity
HPY12_17735	COG0748	coenzyme F420 binding
HPY12_17740	COG3721	Heme iron utilization protein
HPY12_17750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY12_17755	COG0811	peptide transport
HPY12_17760	COG0848	biopolymer transport protein
HPY12_17765	COG4558	Periplasmic binding protein
HPY12_17770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY12_17775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY12_17810	COG0633	Ferredoxin
HPY12_17810	COG3217	Mosc domain protein beta barrel domain protein
HPY12_17810	COG0633	Ferredoxin
HPY12_17810	COG3217	Mosc domain protein beta barrel domain protein
HPY12_17815	COG0418	dihydroorotase activity
HPY12_17825	COG3152	Membrane
HPY12_17835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY12_17840	COG2354	Protein conserved in bacteria
HPY12_17845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY12_17850	COG1278	Cold shock
HPY12_17875	COG3706	GGDEF domain
HPY12_17880	COG1349	DNA-binding transcription factor activity
HPY12_17895	COG3833	ABC-type maltose transport systems, permease component
HPY12_17900	COG1175	transmembrane transport
HPY12_17910	COG3842	ATPase activity
HPY12_17930	COG0393	Putative heavy-metal-binding
HPY12_17940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY12_17945	COG0835	chemotaxis
HPY12_17945	COG0784	Response regulator, receiver
HPY12_17950	COG1846	Transcriptional regulator
HPY12_17955	COG3706	GGDEF domain
HPY12_17990	COG0583	DNA-binding transcription factor activity
HPY12_17995	COG5001	Diguanylate cyclase
HPY12_18005	COG1741	Belongs to the pirin family
HPY12_18010	COG3123	guanosine phosphorylase activity
HPY12_18020	COG2211	Major facilitator Superfamily
HPY12_18025	COG0840	transmembrane signaling receptor activity
HPY12_18030	COG1067	ATP-dependent peptidase activity
HPY12_18040	COG4172	Belongs to the ABC transporter superfamily
HPY12_18060	COG0583	DNA-binding transcription factor activity
HPY12_18070	COG1620	l-lactate permease
HPY12_18085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY12_18095	COG0840	transmembrane signaling receptor activity
HPY12_18105	COG0513	Belongs to the DEAD box helicase family
HPY12_18110	COG0583	DNA-binding transcription factor activity
HPY12_18120	COG1902	pentaerythritol trinitrate reductase activity
HPY12_18130	COG1132	(ABC) transporter
HPY12_18140	COG1902	pentaerythritol trinitrate reductase activity
HPY12_18150	COG1280	lysine exporter protein (LysE YggA)
HPY12_18155	COG2207	Transcriptional regulator
HPY12_18175	COG1846	Transcriptional regulator
HPY12_18180	COG1764	response to oxidative stress
HPY12_18185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY12_18190	COG0697	spore germination
HPY12_18200	COG0700	Nucleoside recognition
HPY12_18205	COG3366	ferrous iron transmembrane transporter activity
HPY12_18210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY12_18220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY12_18225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY12_18230	COG2259	Doxx family
HPY12_18255	COG0363	glucosamine-6-phosphate deaminase activity
HPY12_18270	COG4580	involved in the transport of maltose and maltodextrins
HPY12_18285	COG0840	transmembrane signaling receptor activity
HPY12_18300	COG0840	transmembrane signaling receptor activity
HPY12_18310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY12_18315	COG1126	abc transporter atp-binding protein
HPY12_18325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY12_18330	COG4597	amino acid ABC transporter
HPY12_18335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY12_18340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY12_18340	COG2213	PTS system mannitol-specific
HPY12_18345	COG0246	Mannitol dehydrogenase
HPY12_18350	COG3722	fumarate hydratase activity
HPY12_18355	COG0673	inositol 2-dehydrogenase activity
HPY12_18395	COG1335	isochorismatase
HPY12_18405	COG2910	NAD(P)H-binding
HPY12_18415	COG0840	transmembrane signaling receptor activity
HPY12_18420	COG4221	oxidoreductase activity
HPY12_18430	COG1901	pseudouridine methyltransferase
HPY12_18440	COG0531	amino acid
HPY12_18445	COG1982	Orn Lys Arg decarboxylase major
HPY12_18475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY12_18500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY12_18540	COG0745	RESPONSE REGULATOR receiver
HPY12_18565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY12_18570	COG0840	transmembrane signaling receptor activity
HPY12_18575	COG0835	chemotaxis
HPY12_18580	COG0835	chemotaxis
HPY12_18585	COG0643	Histidine kinase
HPY12_18585	COG2198	Histidine kinase
HPY12_18605	COG0601	transmembrane transport
HPY12_18610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY12_18620	COG2194	sulfuric ester hydrolase activity
HPY12_18625	COG0642	Histidine kinase
HPY12_18630	COG0745	RESPONSE REGULATOR receiver
HPY12_18660	COG1444	tRNA N-acetyltransferase activity
HPY12_18665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine