locus-tag	class	description
HPY05_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPY05_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY05_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPY05_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY05_00030	ENOG4108ZNX	Heat shock protein
HPY05_00035	ENOG4105JKW	Valine--pyruvate aminotransferase
HPY05_00040	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HPY05_00045	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HPY05_00060	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HPY05_00070	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HPY05_00075	ENOG4105C7B	Threonine dehydratase
HPY05_00080	ENOG4105C01	Dihydroxy-acid dehydratase
HPY05_00085	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPY05_00100	ENOG4105C0P	Mg chelatase subunit ChlI
HPY05_00105	ENOG4106HNH	Acyl-transferase
HPY05_00110	ENOG4108Z33	Thiol disulfide Interchange Protein
HPY05_00115	ENOG4105E27	serine threonine protein kinase
HPY05_00125	ENOG4105PC1	Conserved Protein
HPY05_00135	ENOG4108N23	SpoOM-related protein
HPY05_00140	ENOG4108UT2	hemolysin iii
HPY05_00150	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY05_00155	ENOG4105C1A	potassium transporter peripheral membrane
HPY05_00160	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HPY05_00175	ENOG4108WZM	domain protein
HPY05_00180	ENOG4105C79	DNA protecting protein DprA
HPY05_00185	ENOG4108RPN	Protein smg homolog
HPY05_00190	ENOG4108WI1	Dna topoisomerase
HPY05_00195	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HPY05_00200	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HPY05_00205	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY05_00210	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HPY05_00215	ENOG4105E2X	shikimate dehydrogenase
HPY05_00225	ENOG4108Z0R	Transferase
HPY05_00260	ENOG4105WMR	Protein CrcB homolog
HPY05_00265	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HPY05_00275	ENOG4105D06	uba thif-type nad fad binding protein
HPY05_00280	ENOG4105WHD	thiamine biosynthesis protein ThiS
HPY05_00285	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPY05_00290	ENOG4105D41	biosynthesis protein thiH
HPY05_00295	ENOG4105DC7	peptidase M24
HPY05_00295	ENOG4105DC7	peptidase M24
HPY05_00300	ENOG4105G2Y	Transcriptional regulator
HPY05_00305	ENOG4105CNH	Multidrug resistance protein MdtL
HPY05_00315	ENOG4108VVK	transcriptional Regulator, AsnC
HPY05_00320	ENOG4105BZU	Histidine kinase
HPY05_00335	ENOG4105EMK	carboxylate amino acid amine transporter
HPY05_00340	ENOG4108M6U	Universal stress protein A
HPY05_00345	ENOG41090A1	ferritin
HPY05_00350	ENOG4108V6B	universal stress protein B
HPY05_00355	ENOG4105CBX	hi0933 family
HPY05_00365	ENOG4105CGY	Dna recombination protein
HPY05_00370	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPY05_00375	ENOG4105JC1	sterol-binding domain protein
HPY05_00385	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY05_00390	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPY05_00395	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPY05_00400	ENOG4105CA0	peroxidase
HPY05_00405	ENOG4107R73	Mate efflux family protein
HPY05_00415	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPY05_00420	ENOG4105E55	glycerol-3-phosphate acyltransferase
HPY05_00425	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HPY05_00430	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HPY05_00435	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY05_00440	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_00450	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HPY05_00455	ENOG4105F8V	Hydrolase, tatD family
HPY05_00460	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPY05_00470	ENOG4105C2M	dna polymerase I
HPY05_00480	ENOG4106RE7	Cytochrome
HPY05_00490	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HPY05_00495	ENOG4105XCT	Protein of unknown function (DUF2489)
HPY05_00500	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY05_00505	ENOG410601J	HemY protein
HPY05_00510	ENOG4105ECF	c-methyltransferase
HPY05_00515	ENOG41076E6	Uroporphyrinogen-III Synthase
HPY05_00520	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPY05_00525	ENOG4107T0K	Adenylate cyclase
HPY05_00530	ENOG4105XQ6	frataxin-like protein
HPY05_00540	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPY05_00545	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPY05_00550	ENOG4105CT0	Protein of unknown function, DUF484
HPY05_00555	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY05_00560	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HPY05_00565	ENOG4105BZU	Histidine kinase
HPY05_00580	ENOG4105DQF	Hydrolase
HPY05_00585	ENOG4108EUD	Lysophospholipase
HPY05_00590	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY05_00595	ENOG4105D58	Diguanylate phosphodiesterase
HPY05_00600	ENOG4108RMU	ferritin dps family protein
HPY05_00630	ENOG4106H78	methyltransferase
HPY05_00635	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPY05_00640	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPY05_00645	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HPY05_00650	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY05_00655	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HPY05_00670	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HPY05_00675	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY05_00680	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HPY05_00685	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPY05_00750	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPY05_00755	ENOG4105BZU	Histidine kinase
HPY05_00760	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_00765	ENOG4105CUX	Signal transduction histidine kinase
HPY05_00775	ENOG4105C5F	glutamine synthetase
HPY05_00785	ENOG4105CI3	gtp-binding protein typa
HPY05_00795	ENOG4107S2Z	UPF0761 membrane protein
HPY05_00800	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPY05_00815	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HPY05_00820	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HPY05_00825	ENOG4105VEJ	Heat shock protein
HPY05_00830	ENOG4108XKW	General secretion pathway protein C
HPY05_00840	ENOG4107QHF	type ii secretion system protein e
HPY05_00845	ENOG4105D7Q	type ii secretion system
HPY05_00850	ENOG4108VAU	general secretion pathway protein G
HPY05_00855	ENOG4105VWV	general secretion pathway protein h
HPY05_00860	ENOG4105X5Z	General secretion pathway protein I
HPY05_00865	ENOG4108WWZ	General secretion pathway protein J
HPY05_00870	ENOG4108RTD	type II secretion system protein K
HPY05_00875	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HPY05_00880	ENOG4105U1E	general secretion pathway protein M
HPY05_00885	ENOG4105PIC	general secretion pathway protein N
HPY05_00890	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HPY05_00895	ENOG4107RK2	ADP-ribose diphosphatase NudE
HPY05_00905	ENOG4105MJ2	Competence protein
HPY05_00915	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY05_00925	ENOG4105BZM	domain protein
HPY05_00930	ENOG4108RRZ	Transcription elongation factor GreB
HPY05_00935	ENOG4108KHX	Diguanylate cyclase
HPY05_00945	ENOG4105E0F	Histidine kinase
HPY05_00950	ENOG4105C2W	permease
HPY05_00955	ENOG4105CB5	ATP-dependent DNA helicase recG
HPY05_00960	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY05_00965	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HPY05_00970	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPY05_00975	ENOG4105EX9	Membrane
HPY05_00980	ENOG4107QN1	sodium solute
HPY05_01000	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HPY05_01010	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY05_01015	ENOG4108IJ0	Aspartate ammonia-lyase
HPY05_01020	ENOG4105BZU	Histidine kinase
HPY05_01025	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HPY05_01030	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPY05_01040	ENOG4105E0F	Histidine kinase
HPY05_01045	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HPY05_01055	ENOG41076HS	cation diffusion facilitator family transporter
HPY05_01060	ENOG4105CTQ	phosphohexokinase
HPY05_01065	ENOG4105CBT	Fructose-1,6-bisphosphatase
HPY05_01070	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HPY05_01075	ENOG4105SYT	Methylenetetrahydrofolate reductase
HPY05_01080	ENOG4105CFH	Aspartokinase
HPY05_01085	ENOG4105C28	cystathionine
HPY05_01090	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HPY05_01095	ENOG4105C6K	Malic enzyme
HPY05_01100	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPY05_01105	ENOG4105C25	Primosomal protein n'
HPY05_01110	ENOG4105ETE	Transcriptional regulator (LacI family
HPY05_01115	ENOG41063M6	Cell Division Protein
HPY05_01120	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HPY05_01125	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HPY05_01130	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HPY05_01135	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY05_01170	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY05_01175	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY05_01185	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HPY05_01190	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY05_01200	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HPY05_01205	ENOG4105E33	succinate dehydrogenase
HPY05_01215	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HPY05_01220	ENOG4107YZP	Rhodanese domain protein
HPY05_01225	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HPY05_01230	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPY05_01235	ENOG4105D7W	serine acetyltransferase
HPY05_01245	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HPY05_01250	ENOG4105CWC	Acetylornithine deacetylase
HPY05_01255	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPY05_01260	ENOG4105CAS	nag kinase
HPY05_01265	ENOG4105CDH	Citrulline--aspartate ligase
HPY05_01270	ENOG4105CH7	arginosuccinase
HPY05_01280	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY05_01285	ENOG4105EHV	domain protein
HPY05_01295	ENOG4108JQC	penicillin-binding protein 1A
HPY05_01320	ENOG4105E4G	Type IV pilus
HPY05_01325	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPY05_01330	ENOG4105D49	3-dehydroquinate synthase
HPY05_01340	ENOG4105DFE	Dna adenine methylase
HPY05_01345	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPY05_01350	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY05_01355	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPY05_01375	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HPY05_01380	ENOG4105DDQ	anthranilate synthase
HPY05_01385	ENOG4105C8Y	Acetylornithine aminotransferase
HPY05_01395	ENOG4105C26	Dehydrogenase
HPY05_01405	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HPY05_01410	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HPY05_01420	ENOG4105DNZ	Alpha Beta Hydrolase
HPY05_01430	ENOG4105C5H	ABC transporter
HPY05_01435	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPY05_01450	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HPY05_01455	ENOG4105D44	asparaginase
HPY05_01460	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY05_01465	ENOG4108UV7	flagellar protein motX
HPY05_01470	ENOG4105E68	Sulfatase
HPY05_01475	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY05_01480	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPY05_01485	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPY05_01490	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPY05_01495	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPY05_01500	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPY05_01505	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY05_01510	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPY05_01515	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPY05_01520	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPY05_01525	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HPY05_01530	ENOG41083MP	50s ribosomal protein l29
HPY05_01535	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HPY05_01540	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPY05_01545	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPY05_01550	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY05_01555	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPY05_01560	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HPY05_01565	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HPY05_01570	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HPY05_01575	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPY05_01580	ENOG4105VPB	50S ribosomal protein L30
HPY05_01590	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HPY05_01600	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY05_01605	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPY05_01610	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPY05_01615	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY05_01620	ENOG4108ZT0	50S ribosomal protein l17
HPY05_01630	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY05_01635	ENOG4108UBT	opacity-associated protein
HPY05_01640	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY05_01645	ENOG4107YB6	acetyltransferase, (GNAT) family
HPY05_01650	ENOG4105C1J	atp-dependent rna helicase
HPY05_01660	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HPY05_01665	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPY05_01670	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HPY05_01675	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HPY05_01680	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HPY05_01700	ENOG4105C19	ABC transporter
HPY05_01715	ENOG4108UUE	Transcriptional regulator
HPY05_01720	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPY05_01725	ENOG4105CFU	surface antigen
HPY05_01735	ENOG41066HZ	AIG2-like family
HPY05_01740	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPY05_01750	ENOG4105DFU	Cell wall formation (By similarity)
HPY05_01755	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HPY05_01765	ENOG4106SMU	thiamine transporter membrane protein
HPY05_01770	ENOG4107T0D	ABC, transporter
HPY05_01775	ENOG4105N42	UPF0307 protein
HPY05_01780	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HPY05_01785	ENOG4105CJW	magnesium transporter
HPY05_01790	ENOG41080Z8	PHOSPHOCARRIER protein
HPY05_01795	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPY05_01800	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HPY05_01805	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HPY05_01810	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY05_01815	ENOG4108IUZ	ABC transporter
HPY05_01820	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HPY05_01830	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HPY05_01835	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY05_01845	ENOG4105DHJ	ABC, transporter
HPY05_01850	ENOG4105CY3	ABC transporter, permease
HPY05_01855	ENOG4107PE3	Mammalian cell entry related domain protein
HPY05_01860	ENOG4105E3I	toluene tolerance
HPY05_01870	ENOG4105VFK	BolA family
HPY05_01875	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPY05_01880	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HPY05_01885	ENOG4105KME	endoribonuclease L-psp
HPY05_01895	ENOG4105CXT	aspartate transcarbamylase
HPY05_01905	ENOG4108IAB	Phoh family
HPY05_01920	ENOG4105D3G	Pseudouridine synthase
HPY05_01925	ENOG4105C5I	Dehydrogenase
HPY05_01930	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPY05_01935	ENOG4105MYG	DNA polymerase iii, chi subunit
HPY05_01940	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY05_01945	ENOG4108M8S	permease YjgP YjgQ family protein
HPY05_01950	ENOG4108K5H	permease YjgP YjgQ family protein
HPY05_01965	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY05_02005	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY05_02010	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY05_02015	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPY05_02040	ENOG41064T2	transcriptional regulator, lysR family
HPY05_02045	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY05_02050	ENOG4105C7K	acetolactate synthase
HPY05_02055	ENOG4108ZP8	Acetolactate synthase small subunit
HPY05_02060	ENOG4108JQ1	Dehydrogenase
HPY05_02065	ENOG4105E66	phosphoriboisomerase A
HPY05_02070	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HPY05_02080	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HPY05_02090	ENOG4105D0A	hydroxylase
HPY05_02095	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY05_02110	ENOG4105Y75	tpr repeat protein
HPY05_02120	ENOG4108IYU	L-aspartate oxidase
HPY05_02125	ENOG4105EMN	RNA polymerase sigma factor
HPY05_02140	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
HPY05_02145	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPY05_02150	ENOG4105C3F	Signal peptidase i
HPY05_02155	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPY05_02160	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPY05_02165	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HPY05_02170	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HPY05_02175	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HPY05_02195	ENOG4105BZU	Histidine kinase
HPY05_02205	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY05_02210	ENOG4105DXN	mazG family
HPY05_02215	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HPY05_02220	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPY05_02225	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HPY05_02240	ENOG4106MWK	domain protein
HPY05_02245	ENOG4105CJ3	phosphate transporter
HPY05_02250	ENOG4107IX6	phosphate transport regulator
HPY05_02255	ENOG4105I7R	Adenylate cyclase
HPY05_02260	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_02265	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPY05_02275	ENOG4105DFG	type I secretion outer membrane protein
HPY05_02280	ENOG41087AY	ADP-Ribose pyrophosphatase
HPY05_02285	ENOG4108SX3	cytoplasmic protein
HPY05_02290	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HPY05_02295	ENOG4105IPS	esterase
HPY05_02300	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY05_02305	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY05_02315	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HPY05_02320	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPY05_02325	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HPY05_02330	ENOG4105D7Q	type ii secretion system
HPY05_02335	ENOG4107QHF	type ii secretion system protein e
HPY05_02345	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HPY05_02355	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY05_02360	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY05_02365	ENOG4105T95	Thiol disulfide interChange protein
HPY05_02370	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HPY05_02375	ENOG41073TP	transcriptional regulator
HPY05_02380	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPY05_02385	ENOG4107QSN	dihydrolipoamide acetyltransferase
HPY05_02390	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY05_02405	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPY05_02410	ENOG4105CJN	penicillin-binding protein
HPY05_02415	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPY05_02420	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HPY05_02430	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPY05_02440	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HPY05_02445	ENOG4105DFU	Cell wall formation (By similarity)
HPY05_02450	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HPY05_02455	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HPY05_02460	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPY05_02465	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY05_02475	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY05_02480	ENOG4105M6F	mutator MutT protein
HPY05_02485	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPY05_02495	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HPY05_02500	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPY05_02520	ENOG4105EJ9	Membrane
HPY05_02525	ENOG4105VP0	transcriptional regulator, lysR family
HPY05_02530	ENOG4105EN6	Membrane
HPY05_02535	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HPY05_02545	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPY05_02555	ENOG4105BZ8	glutamate synthase
HPY05_02560	ENOG4105CBC	glutamate synthase
HPY05_02575	ENOG4105N5T	Radical SAM Protein
HPY05_02585	ENOG4105BZU	Histidine kinase
HPY05_02590	ENOG41065U4	response regulator
HPY05_02600	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY05_02620	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPY05_02625	ENOG4105D98	threonine synthase
HPY05_02630	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HPY05_02635	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HPY05_02640	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPY05_02655	ENOG4105BZG	amino acid carrier protein
HPY05_02660	ENOG4105D1Q	UPF0246 protein
HPY05_02670	ENOG4105EYA	deoxyribonuclease
HPY05_02675	ENOG4105D9N	nucleoside
HPY05_02685	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HPY05_02690	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HPY05_02695	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HPY05_02700	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY05_02710	ENOG4105EAC	phosphoserine phosphatase
HPY05_02720	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPY05_02725	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY05_02730	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY05_02735	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY05_02745	ENOG4105CNT	hydrolase family 2
HPY05_02750	ENOG41060NJ	transcriptional regulator
HPY05_02755	ENOG4108Y51	tRNA-binding protein
HPY05_02770	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY05_02775	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY05_02785	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HPY05_02790	ENOG4105X2V	dna damage-inducible protein
HPY05_02805	ENOG4105DSY	exodeoxyribonuclease V, gamma
HPY05_02810	ENOG4107QKA	exodeoxyribonuclease V beta
HPY05_02815	ENOG4107QYX	exodeoxyribonuclease v alpha
HPY05_02825	ENOG4107QZM	n-acetylglutamate synthase
HPY05_02835	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HPY05_02840	ENOG4105CUZ	uba thif-type nad fad binding protein
HPY05_02845	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HPY05_02850	ENOG4105C9B	Cysteine desulfurase
HPY05_02855	ENOG4107S0N	DJ-1 family
HPY05_02860	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPY05_02865	ENOG4105DRB	nucleoside-specific channel-forming protein
HPY05_02875	ENOG4105K6V	RNA polymerase
HPY05_02885	ENOG4105EYM	Major Facilitator superfamily
HPY05_02890	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY05_02900	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY05_02905	ENOG4105M85	Bola protein
HPY05_02910	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY05_02915	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY05_02920	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY05_02925	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY05_02930	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY05_02935	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HPY05_02940	ENOG4105CJ2	(LipO)protein
HPY05_02960	ENOG4105BZU	Histidine kinase
HPY05_02965	ENOG4105C8J	)-transporter
HPY05_02970	ENOG4105VNT	transposase (IS4 family) protein
HPY05_02980	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY05_02985	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY05_02990	ENOG4105CIN	aminoacyl-histidine dipeptidase
HPY05_02995	ENOG4105C7N	Xanthine uracil vitamin C permease
HPY05_03000	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HPY05_03005	ENOG4108DJV	Fermentation respiration switch protein
HPY05_03010	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HPY05_03015	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPY05_03020	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPY05_03025	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPY05_03030	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY05_03045	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HPY05_03050	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HPY05_03055	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HPY05_03060	ENOG4108ZAI	phosphatidylglycerophosphatase a
HPY05_03065	ENOG4108T8E	UPF0325 protein
HPY05_03070	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HPY05_03075	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPY05_03080	ENOG4105CE9	30S ribosomal protein S2
HPY05_03085	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HPY05_03090	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPY05_03095	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPY05_03100	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPY05_03105	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPY05_03110	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPY05_03115	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPY05_03125	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HPY05_03130	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY05_03135	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HPY05_03140	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY05_03145	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY05_03150	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY05_03155	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPY05_03160	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HPY05_03165	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HPY05_03170	ENOG4105N7H	Cytochrome
HPY05_03175	ENOG4105PY6	Phenolic acid decarboxylase
HPY05_03180	ENOG4108YZA	Nitrogen regulatory protein pii
HPY05_03185	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HPY05_03190	ENOG4105E9H	Lytic Murein transglycosylase
HPY05_03195	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPY05_03200	ENOG4105D1A	Methyltransferase
HPY05_03205	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY05_03210	ENOG4107RZZ	dna polymerase iii epsilon subunit
HPY05_03220	ENOG4107QPN	acyl-Coa dehydrogenase
HPY05_03225	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY05_03230	ENOG4105E7A	Glutamine amidotransferase
HPY05_03235	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HPY05_03240	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPY05_03245	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HPY05_03250	ENOG4105BZU	Histidine kinase
HPY05_03255	ENOG4105FE9	pseudouridine synthase
HPY05_03260	ENOG4108DG9	Smr protein MutS2
HPY05_03280	ENOG4105E2D	ec 3.2.1.52
HPY05_03295	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPY05_03300	ENOG4105UYK	outer membrane protein a
HPY05_03310	ENOG4107RBR	Receptor
HPY05_03315	ENOG4105Q26	Siderophore-interacting protein
HPY05_03320	ENOG4105C0W	non-ribosomal peptide synthetase
HPY05_03355	ENOG4107R88	Chemotaxis protein (CheV)
HPY05_03360	ENOG4105BZU	Histidine kinase
HPY05_03365	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPY05_03370	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPY05_03375	ENOG4105W00	Flagellar hook capping protein
HPY05_03380	ENOG4105BZE	flagellar hook protein, FlgE
HPY05_03385	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPY05_03390	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPY05_03395	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY05_03400	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY05_03405	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPY05_03420	ENOG4105I03	Flagellin
HPY05_03425	ENOG4105I03	Flagellin
HPY05_03510	ENOG4105C3G	gtp-binding protein
HPY05_03515	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPY05_03520	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPY05_03525	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPY05_03530	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HPY05_03535	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPY05_03540	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPY05_03545	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPY05_03550	ENOG4108YY7	Invasion gene expression up-regulator SirB
HPY05_03555	ENOG41063JG	Transcriptional regulator
HPY05_03560	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY05_03565	ENOG4105CGH	5'-nucleotidase
HPY05_03570	ENOG4108Z66	YbaK ebsC protein
HPY05_03575	ENOG4105C2W	permease
HPY05_03590	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HPY05_03595	ENOG4105K89	arsenate reductase
HPY05_03600	ENOG4105ERG	peptidase m48, ste24p
HPY05_03615	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_03620	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY05_03635	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY05_03655	ENOG4105KUZ	arsenate reductase
HPY05_03670	ENOG4105QZU	Inner membrane protein YfeZ
HPY05_03675	ENOG4105EZR	dyp-type peroxidase family protein
HPY05_03680	ENOG4105I03	Flagellin
HPY05_03685	ENOG4105I03	Flagellin
HPY05_03690	ENOG4105I03	Flagellin
HPY05_03695	ENOG41063QE	flagellar protein FlaG
HPY05_03700	ENOG4107W9T	flagellar hook-associated
HPY05_03710	ENOG4105MQ3	flagellar protein FliS
HPY05_03720	ENOG4105BZU	Histidine kinase
HPY05_03730	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HPY05_03735	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPY05_03740	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY05_03745	ENOG4105W2B	Flagellar assembly protein
HPY05_03750	ENOG4108JIR	Flagellum-specific ATP synthase
HPY05_03770	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY05_03775	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY05_03780	ENOG4105DD5	Flagellar motor switch protein
HPY05_03785	ENOG4105VTB	flagellar biosynthesis protein fliO
HPY05_03790	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPY05_03795	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPY05_03800	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPY05_03805	ENOG4105D00	flagellar biosynthetic protein flhB
HPY05_03810	ENOG4108DG9	Smr protein MutS2
HPY05_03815	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HPY05_03820	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPY05_03825	ENOG4105EN6	Membrane
HPY05_03830	ENOG4108BPE	-transporting atpase
HPY05_03835	ENOG4105MH2	YfcL protein
HPY05_03840	ENOG4105Q8W	reductase
HPY05_03845	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HPY05_03850	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY05_03855	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HPY05_03860	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY05_03865	ENOG41090R7	Ferric uptake
HPY05_03875	ENOG4105CMU	LysR family (Transcriptional regulator
HPY05_03880	ENOG4105VAW	lrga family
HPY05_03885	ENOG41067MG	lrgb family
HPY05_03890	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY05_03900	ENOG4105EV9	Alpha Beta Hydrolase
HPY05_03905	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HPY05_03910	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HPY05_03920	ENOG4107QNR	UPF0135 protein
HPY05_03925	ENOG4105BZN	citrate synthase
HPY05_03930	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HPY05_03935	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HPY05_03940	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HPY05_03945	ENOG4105E33	succinate dehydrogenase
HPY05_03950	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPY05_03955	ENOG4105C7S	Dehydrogenase
HPY05_03960	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HPY05_03965	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HPY05_03970	ENOG4105FAV	ABC, transporter
HPY05_03975	ENOG4105FDK	ABC transporter
HPY05_03980	ENOG4105NXV	High-affinity zinc uptake system protein
HPY05_03985	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HPY05_03990	ENOG4105XFK	Ferrous iron transport protein A
HPY05_04010	ENOG4105C75	arginyL-tRNA synthetase
HPY05_04020	ENOG4108JQM	Insulinase (Peptidase family M16)
HPY05_04025	ENOG4108BY2	phosphohistidine phosphatase
HPY05_04030	ENOG4105D7B	Flagellar biosynthesis protein flha
HPY05_04045	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY05_04050	ENOG4108VYJ	response regulator receiver protein
HPY05_04055	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HPY05_04065	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY05_04070	ENOG4107QJE	Chromosome Partitioning Protein
HPY05_04080	ENOG4108V3W	Chemotaxis protein, CheW
HPY05_04090	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HPY05_04095	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HPY05_04100	ENOG41060IM	Heme exporter protein
HPY05_04105	ENOG41067VX	Heme exporter protein
HPY05_04110	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HPY05_04115	ENOG4105DA4	cytochrome c-type biogenesis protein
HPY05_04120	ENOG4107QX9	Thiol disulfide interChange protein
HPY05_04125	ENOG4108M1T	Cytochrome c-type biogenesis protein
HPY05_04135	ENOG410903C	(LipO)protein
HPY05_04150	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY05_04155	ENOG4105M2J	Glutaredoxin
HPY05_04160	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY05_04165	ENOG4105DGU	Histone deacetylase
HPY05_04180	ENOG4105E68	Sulfatase
HPY05_04185	ENOG4105YDX	UPF0352 protein
HPY05_04190	ENOG4106V8H	Nucleoid-associated protein
HPY05_04200	ENOG4105DFD	Na H antiporter
HPY05_04205	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY05_04210	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPY05_04215	ENOG4105C0A	alcohol dehydrogenase
HPY05_04225	ENOG4105CHH	sulfate transporter
HPY05_04230	ENOG4105C03	ribonuclease
HPY05_04235	ENOG4105EI2	Pseudouridine synthase
HPY05_04240	ENOG4108UHJ	MAF-like protein
HPY05_04245	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HPY05_04250	ENOG4105VGS	50s ribosomal protein l32
HPY05_04255	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HPY05_04260	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY05_04265	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HPY05_04270	ENOG4105CHR	reductase
HPY05_04275	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPY05_04280	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY05_04285	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HPY05_04290	ENOG4105HHA	aminodeoxychorismate lyase
HPY05_04295	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPY05_04300	ENOG4107QRG	dna polymerase iii
HPY05_04305	ENOG4105F8V	Hydrolase, tatD family
HPY05_04310	ENOG4105CI1	PTS System
HPY05_04320	ENOG4105C8J	)-transporter
HPY05_04335	ENOG4108NRW	Phospholipase, patatin family
HPY05_04340	ENOG4105CA9	Pyruvate kinase
HPY05_04345	ENOG4105DAG	ROK family
HPY05_04365	ENOG4105DHI	Methyltransferase
HPY05_04375	ENOG4105DSB	aldose 1-epimerase
HPY05_04380	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY05_04385	ENOG4105E0X	reductase
HPY05_04395	ENOG4105VUT	cytoplasmic protein
HPY05_04400	ENOG4105HDK	L-asparaginase
HPY05_04405	ENOG4105D07	Signal peptide peptidase, SppA
HPY05_04410	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY05_04415	ENOG4105CIY	formyltetrahydrofolate deformylase
HPY05_04425	ENOG4105DVT	helicase
HPY05_04430	ENOG41072GX	Peptidase M22 Glycoprotease
HPY05_04445	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY05_04450	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY05_04455	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HPY05_04475	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY05_04480	ENOG4105DK2	UPF0207 protein
HPY05_04485	ENOG4105CHM	Aminotransferase
HPY05_04490	ENOG4105E4F	Isochorismate synthase
HPY05_04495	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPY05_04500	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HPY05_04505	ENOG4108IPT	Naphthoate synthase
HPY05_04515	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY05_04520	ENOG4105DKK	Benzoate
HPY05_04525	ENOG4107S74	Lysophospholipid transporter LplT
HPY05_04550	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HPY05_04555	ENOG4107QMS	site-determining protein
HPY05_04560	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HPY05_04565	ENOG4105VNG	YcgL domain-containing protein
HPY05_04570	ENOG4105CVE	Lytic murein transglycosylase
HPY05_04575	ENOG4105JQN	Transcriptional regulator
HPY05_04580	ENOG4105D9N	nucleoside
HPY05_04585	ENOG4105CUW	cytochrome C-TYPE protein
HPY05_04590	ENOG4107QY8	reductase
HPY05_04600	ENOG4105JQN	Transcriptional regulator
HPY05_04620	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HPY05_04655	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPY05_04665	ENOG4105BZU	Histidine kinase
HPY05_04675	ENOG4105CNG	UPF0061 protein
HPY05_04680	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPY05_04685	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HPY05_04690	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY05_04695	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_04710	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPY05_04715	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPY05_04720	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPY05_04725	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HPY05_04730	ENOG4105K70	DNA-binding protein
HPY05_04735	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HPY05_04740	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HPY05_04745	ENOG4105CAT	Cytidine monophosphate kinase
HPY05_04750	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPY05_04755	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY05_04760	ENOG4105Q4A	inner membrane protein yciS
HPY05_04765	ENOG4105CFV	Tetratricopeptide repeat protein
HPY05_04775	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HPY05_04785	ENOG4107R11	Transcriptional regulator
HPY05_04795	ENOG4105DCF	alanine dehydrogenase
HPY05_04800	ENOG4105EW9	transcriptional regulator AsnC family
HPY05_04805	ENOG4105CNU	cell division protein FtsK
HPY05_04810	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HPY05_04815	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY05_04820	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HPY05_04830	ENOG4108NVR	Methyl-accepting chemotaxis
HPY05_04835	ENOG4105K59	histidine triad (HIT) protein
HPY05_04860	ENOG4105D0Y	UPF0227 protein
HPY05_04865	ENOG4105CEP	NADH dehydrogenase
HPY05_04880	ENOG4106M3D	hemolysin
HPY05_04890	ENOG4108JA2	transcriptioN-repair coupling factor
HPY05_04905	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY05_04910	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY05_04920	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HPY05_04925	ENOG4105BZ1	(ABC) transporter
HPY05_04930	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HPY05_04935	ENOG4105W49	UPF0434 protein
HPY05_04940	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY05_04945	ENOG4105ED1	spovr family
HPY05_04950	ENOG4106AKX	UPF0229 protein
HPY05_04955	ENOG4105CYN	Serine protein kinase
HPY05_04960	ENOG4105VNT	transposase (IS4 family) protein
HPY05_04965	ENOG4105XWI	UPF0304 protein
HPY05_04975	ENOG4105F1A	Pyruvate formate-lyase
HPY05_04980	ENOG4108N3W	hemolysin secretion protein
HPY05_04990	ENOG4105C6N	Formate acetyltransferase
HPY05_05000	ENOG4108JEH	abc transporter atp-binding protein
HPY05_05005	ENOG4105E89	ABC transporter
HPY05_05010	ENOG4105DSP	amino acid AbC transporter
HPY05_05015	ENOG4106YG3	ABC transporter
HPY05_05020	ENOG4105CGK	Exodeoxyribonuclease III
HPY05_05025	ENOG4106428	Protein of unknown function (DUF2496)
HPY05_05030	ENOG4108URS	primosomal replication protein n''
HPY05_05035	ENOG4105EJ9	Membrane
HPY05_05040	ENOG4105DVT	helicase
HPY05_05055	ENOG4105K5B	UPF0225 protein
HPY05_05060	ENOG4105D58	Diguanylate phosphodiesterase
HPY05_05065	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HPY05_05070	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY05_05075	ENOG4105C8N	cysteinyl-tRNA synthetase
HPY05_05080	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPY05_05085	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPY05_05095	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY05_05100	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY05_05110	ENOG4105KJB	cyd operon protein YbgE
HPY05_05115	ENOG4107YD3	Thioesterase
HPY05_05120	ENOG4105E02	MotA TolQ exbB proton channel
HPY05_05125	ENOG4105M8F	Biopolymer transport protein exbD tolR
HPY05_05135	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HPY05_05140	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HPY05_05150	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HPY05_05160	ENOG4105BZU	Histidine kinase
HPY05_05165	ENOG4108RNS	Exports L-alanine (By similarity)
HPY05_05170	ENOG4105EIP	mannose-6-phosphate isomerase
HPY05_05175	ENOG4105DM4	PTS System
HPY05_05180	ENOG4106R3P	AraC family transcriptional regulator
HPY05_05190	ENOG4108YRF	PTS System
HPY05_05195	ENOG4105DM4	PTS System
HPY05_05200	ENOG4105DM4	PTS System
HPY05_05210	ENOG4105C26	Dehydrogenase
HPY05_05215	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HPY05_05220	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY05_05230	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY05_05315	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPY05_05325	ENOG4105KT5	UmuD protein
HPY05_05365	ENOG4105MRD	Phage derived protein Gp49-like (DUF891)
HPY05_05410	ENOG4105T95	Thiol disulfide interChange protein
HPY05_05470	ENOG4105F88	accessory colonization factor AcfD
HPY05_05500	ENOG4105VT2	5-hydroxyisourate hydrolase
HPY05_05515	ENOG4107VGF	ig domain protein group 2 domain protein
HPY05_05520	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY05_05525	ENOG4105XB6	Toxin coregulated pilin
HPY05_05540	ENOG4105GRU	toxin co-regulated pilus biosynthesis outer membrane protein C
HPY05_05560	ENOG4107QHF	type ii secretion system protein e
HPY05_05565	ENOG4108VEY	type ii secretion system
HPY05_05605	ENOG4108MA4	Peptidase M66
HPY05_05630	ENOG4108M3R	transcriptional activator CadC
HPY05_05635	ENOG4105BZS	acriflavin resistance protein
HPY05_05680	ENOG4108UUM	single-stranded DNA-binding protein
HPY05_05700	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
HPY05_05725	ENOG4108YGG	dna repair protein
HPY05_05765	ENOG410679B	prophage CP4-57 regulatory protein alpA
HPY05_05770	ENOG4105DFP	Integrase
HPY05_05785	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HPY05_05795	ENOG4105DY2	Paraquat-inducible protein b
HPY05_05800	ENOG4105F1S	paraquat-inducible protein a
HPY05_05825	ENOG4108R86	Transcriptional regulator
HPY05_05830	ENOG4105C26	Dehydrogenase
HPY05_05835	ENOG4105MTM	Protein of unknown function (DUF1496)
HPY05_05845	ENOG41067SE	Tetr family transcriptional regulator
HPY05_05850	ENOG4107QPN	acyl-Coa dehydrogenase
HPY05_05860	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPY05_05865	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HPY05_05870	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HPY05_05880	ENOG4105RKX	Protein of unknown function (DUF2498)
HPY05_05885	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY05_05890	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY05_05895	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPY05_05915	ENOG4105HP8	regulator of competence-specific genes
HPY05_05920	ENOG4105ETE	Transcriptional regulator (LacI family
HPY05_05930	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HPY05_05935	ENOG4107S90	membrAne
HPY05_05940	ENOG4106371	Methyltransferase
HPY05_05945	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HPY05_05950	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HPY05_05960	ENOG4105EW9	transcriptional regulator AsnC family
HPY05_05965	ENOG4108VP3	Lysine exporter protein (LysE YggA)
HPY05_05970	ENOG4105CCT	upf0313 protein
HPY05_05995	ENOG4105DZ2	Transcriptional regulator
HPY05_06000	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HPY05_06010	ENOG4105K9H	YciI-like protein
HPY05_06015	ENOG4105NAU	thioesterase Superfamily protein
HPY05_06030	ENOG4105GFG	DUF218 domain
HPY05_06035	ENOG4107SRH	Nad-dependent epimerase dehydratase
HPY05_06045	ENOG4105TMB	Formate nitrite transporter
HPY05_06060	ENOG4107QY8	reductase
HPY05_06080	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HPY05_06100	ENOG4108JQ2	peptide transport system atp-binding protein
HPY05_06105	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HPY05_06110	ENOG4108EU3	peptide transport system, permease
HPY05_06115	ENOG4108I5W	peptide transport system, permease protein
HPY05_06120	ENOG4108J59	Extracellular solute-binding protein, family 5
HPY05_06125	ENOG4105E51	psp operon transcriptional activator
HPY05_06130	ENOG41087YS	Phage shock protein A
HPY05_06145	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPY05_06160	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HPY05_06165	ENOG4105C28	cystathionine
HPY05_06175	ENOG4105C8J	)-transporter
HPY05_06180	ENOG4108W1A	pseudouridine synthase
HPY05_06185	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HPY05_06190	ENOG4108VGW	abc transporter atp-binding protein
HPY05_06195	ENOG4105CXZ	ABC transporter, permease
HPY05_06200	ENOG4105VNH	ABC transporter solute-binding protein
HPY05_06210	ENOG4105XZD	Fe-S protein
HPY05_06220	ENOG4105C44	Serine transporter
HPY05_06230	ENOG4105CJW	magnesium transporter
HPY05_06235	ENOG4105BZU	Histidine kinase
HPY05_06240	ENOG4105BZU	Histidine kinase
HPY05_06250	ENOG4105KXC	Collagenase
HPY05_06285	ENOG4108N3W	hemolysin secretion protein
HPY05_06300	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPY05_06305	ENOG4105BZU	Histidine kinase
HPY05_06325	ENOG4105I08	Pseudouridine synthase
HPY05_06330	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY05_06340	ENOG4105CGD	Nad-dependent epimerase dehydratase
HPY05_06345	ENOG4105UQX	Mate efflux family protein
HPY05_06350	ENOG4108I0Y	(ABC) transporter
HPY05_06365	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY05_06375	ENOG4105E3Q	saccharopine dehydrogenase
HPY05_06380	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HPY05_06385	ENOG4105CDV	Ompa motb domain protein
HPY05_06390	ENOG4105DFG	type I secretion outer membrane protein
HPY05_06460	ENOG4105F04	LysR family Transcriptional regulator
HPY05_06470	ENOG4108VKG	metal-dependent hydrolase
HPY05_06475	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HPY05_06485	ENOG41090FY	type IV pilus biogenesis stability protein PilW
HPY05_06490	ENOG4105CVG	Homoserine O-transsuccinylase
HPY05_06510	ENOG4107V40	secretion protein, HlyD family
HPY05_06525	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY05_06530	ENOG4106YYS	transcriptional regulatory protein
HPY05_06540	ENOG4107R88	Chemotaxis protein (CheV)
HPY05_06590	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPY05_06595	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPY05_06600	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPY05_06610	ENOG4105C7K	acetolactate synthase
HPY05_06615	ENOG4107FQX	Alpha-acetolactate decarboxylase
HPY05_06625	ENOG4105F88	accessory colonization factor AcfD
HPY05_06635	ENOG4105CH6	catalase
HPY05_06645	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY05_06655	ENOG4108TWJ	NADH dehydrogenase subunit 5
HPY05_06660	ENOG4105DUM	transcriptional regulator, lysR family
HPY05_06680	ENOG4105V0I	UPF0267 protein
HPY05_06695	ENOG4105C9Q	fumarate hydratase class II
HPY05_06705	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY05_06710	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY05_06715	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY05_06720	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY05_06725	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY05_06735	ENOG4107QZV	Type I secretion membrane fusion protein
HPY05_06760	ENOG4108M8W	Monooxygenase
HPY05_06765	ENOG4108XDE	Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis
HPY05_06775	ENOG4105E09	nadh pyrophosphatase
HPY05_06780	ENOG4106MXH	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY05_06795	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY05_06805	ENOG4105CS2	ec 3.2.1.21
HPY05_06810	ENOG4105DDV	Transcriptional regulator (LacI family
HPY05_06815	ENOG4105M4H	endoribonuclease L-psp
HPY05_06820	ENOG4105XEP	YhcH YjgK YiaL family protein
HPY05_06825	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HPY05_06830	ENOG4105E98	transcriptional regulator DeoR family
HPY05_06835	ENOG4108IJ9	(ABC) transporter
HPY05_06840	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HPY05_06870	ENOG4109015	Biopolymer transport protein exbD tolR
HPY05_06875	ENOG41067XB	TonB family
HPY05_06895	ENOG4107QI1	Mate efflux family protein
HPY05_06915	ENOG4107TT5	NLP P60 protein
HPY05_06920	ENOG4108N3W	hemolysin secretion protein
HPY05_06930	ENOG4106IUH	DTW domain containing protein
HPY05_06935	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HPY05_06950	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY05_06955	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HPY05_06960	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY05_06965	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HPY05_06975	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_06980	ENOG4105BZU	Histidine kinase
HPY05_06985	ENOG4105C5H	ABC transporter
HPY05_06990	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPY05_07010	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY05_07020	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY05_07025	ENOG4105QAX	Iron-sulfur
HPY05_07040	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HPY05_07045	ENOG4108VPT	UPF0234 protein
HPY05_07050	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY05_07065	ENOG4105QNR	S1 RNA binding domain protein
HPY05_07075	ENOG4105DY2	Paraquat-inducible protein b
HPY05_07080	ENOG4105H2K	paraquat-inducible protein a
HPY05_07085	ENOG4105BZ1	(ABC) transporter
HPY05_07090	ENOG4108ZGC	gaf domain protein
HPY05_07095	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HPY05_07100	ENOG4105CN1	protease
HPY05_07110	ENOG4105CD8	aminopeptidase N
HPY05_07120	ENOG4105C7I	Dehydrogenase
HPY05_07125	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPY05_07130	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HPY05_07135	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HPY05_07145	ENOG4105C5H	ABC transporter
HPY05_07160	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HPY05_07165	ENOG4105DAN	ATP-dependent protease
HPY05_07170	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
HPY05_07270	ENOG4105EUK	rtx toxin RtxA
HPY05_07275	ENOG4108RC6	RTX toxin
HPY05_07300	ENOG4105BZU	Histidine kinase
HPY05_07330	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HPY05_07340	ENOG4105C59	p-type ATPase
HPY05_07355	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HPY05_07360	ENOG4105Q9Y	Universal stress protein
HPY05_07365	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HPY05_07385	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY05_07395	ENOG4105D38	putrescine abc transporter
HPY05_07400	ENOG4108HM4	ABC transporter
HPY05_07405	ENOG4107RUE	extracellular solute-binding protein family 1
HPY05_07420	ENOG4105BZG	amino acid carrier protein
HPY05_07425	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY05_07455	ENOG4105CS6	Rhs element vgr protein
HPY05_07460	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY05_07465	ENOG4105CTD	carboxy-peptidase
HPY05_07485	ENOG4105C1J	atp-dependent rna helicase
HPY05_07495	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY05_07500	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY05_07505	ENOG4105EJC	lysr family transcriptional regulator
HPY05_07515	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HPY05_07520	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HPY05_07525	ENOG4105R8A	Heat shock protein
HPY05_07535	ENOG4105CQ7	ATP-dependent helicase
HPY05_07555	ENOG4105BZU	Histidine kinase
HPY05_07565	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY05_07570	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY05_07575	ENOG4105BZU	Histidine kinase
HPY05_07585	ENOG4105BZU	Histidine kinase
HPY05_07605	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HPY05_07610	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HPY05_07615	ENOG410667J	hydrolase
HPY05_07625	ENOG4107QXX	ABC transporter
HPY05_07630	ENOG4105EZ7	amino acid ABC transporter
HPY05_07635	ENOG4105DRP	amino acid AbC transporter
HPY05_07640	ENOG4105CDA	abc transporter atp-binding protein
HPY05_07645	ENOG4108MN8	Membrane
HPY05_07650	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HPY05_07655	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HPY05_07660	ENOG4105DR4	Methyltransferase
HPY05_07665	ENOG4106TD9	Diguanylate cyclase
HPY05_07675	ENOG4105BZU	Histidine kinase
HPY05_07680	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY05_07685	ENOG4108RXX	maleylacetoacetate isomerase
HPY05_07695	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HPY05_07700	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPY05_07705	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY05_07720	ENOG4105VNT	transposase (IS4 family) protein
HPY05_07725	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY05_07730	ENOG4105C7F	AcnD-accessory protein PrpF
HPY05_07735	ENOG4108I0Z	Aconitate hydratase
HPY05_07740	ENOG4105BZN	citrate synthase
HPY05_07745	ENOG4105CR4	methylisocitrate lyase
HPY05_07770	ENOG4108PTX	LysR family Transcriptional regulator
HPY05_07775	ENOG4105D05	Receptor
HPY05_07800	ENOG4105EFX	secretion protein, HlyD family
HPY05_07815	ENOG4107SDZ	Galactoside transport system permease protein mglC
HPY05_07820	ENOG4105C2J	ABC transporter
HPY05_07845	ENOG4107EXC	regulatoR
HPY05_07850	ENOG4105GR3	Histidine kinase
HPY05_07855	ENOG4105RW8	MltA-interacting MipA family protein
HPY05_07860	ENOG4108MJ5	VirK protein
HPY05_07865	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_07870	ENOG4105BZU	Histidine kinase
HPY05_07875	ENOG4105C8P	)-transporter
HPY05_07880	ENOG4108NVR	Methyl-accepting chemotaxis
HPY05_07885	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY05_07900	ENOG4105D9U	N-acetyltransferase
HPY05_07905	ENOG4108JU8	Transcriptional regulator
HPY05_07915	ENOG4105CM6	amino acid regulated cytosolic protein
HPY05_07930	ENOG4105CRQ	synthase (Component I)
HPY05_07935	ENOG4105P8F	nudix hydrolase
HPY05_07940	ENOG4105C44	Serine transporter
HPY05_07945	ENOG4105EJQ	L-serine dehydratase
HPY05_07950	ENOG4105VNT	transposase (IS4 family) protein
HPY05_07955	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HPY05_07965	ENOG4108N3W	hemolysin secretion protein
HPY05_07970	ENOG4105C5S	asparaginyl-tRNA synthetase
HPY05_07980	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY05_07985	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY05_08000	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_08005	ENOG4105DJ9	glucan biosynthesis protein
HPY05_08010	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HPY05_08015	ENOG4105C94	Transporter
HPY05_08020	ENOG41067TZ	transcriptional regulator, MarR family
HPY05_08035	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY05_08045	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY05_08060	ENOG4105C5X	domain protein
HPY05_08065	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HPY05_08095	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HPY05_08105	ENOG4105S8Q	sugar efflux transporter
HPY05_08115	ENOG4105C72	UPF0176 protein
HPY05_08120	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY05_08125	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPY05_08130	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY05_08135	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY05_08140	ENOG4107QK7	reductase
HPY05_08165	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_08180	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HPY05_08185	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HPY05_08200	ENOG4108YZT	Adenosylcobinamide kinase
HPY05_08205	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HPY05_08210	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HPY05_08215	ENOG4105E0X	reductase
HPY05_08220	ENOG4108ETY	sodium dicarboxylate symporter
HPY05_08225	ENOG4105CJB	Exodeoxyribonuclease I
HPY05_08230	ENOG4105VAW	lrga family
HPY05_08235	ENOG41067MG	lrgb family
HPY05_08255	ENOG4108RS6	transposase
HPY05_08270	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY05_08275	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HPY05_08280	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPY05_08320	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPY05_08325	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY05_08330	ENOG4105CQ2	DNA polymerase
HPY05_08335	ENOG4105BZU	Histidine kinase
HPY05_08345	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY05_08350	ENOG4108W5H	UPF0263 protein
HPY05_08360	ENOG4105CZE	histidine utilization repressor
HPY05_08365	ENOG4105CI2	imidazolone-5-propionate hydrolase
HPY05_08370	ENOG41088SP	formiminoglutamate hydrolase
HPY05_08375	ENOG4105CGP	Urocanate hydratase
HPY05_08380	ENOG4105C84	Histidine ammonia-lyase
HPY05_08400	ENOG4105CQB	FAD linked oxidase domain protein
HPY05_08415	ENOG4108ZG0	Ompa motb domain protein
HPY05_08435	ENOG4105C8V	SAICAR synthetase
HPY05_08445	ENOG4107R1I	NAD-dependent malic enzyme
HPY05_08455	ENOG4107GZ4	SanA protein
HPY05_08460	ENOG4105BZU	Histidine kinase
HPY05_08465	ENOG4105C9B	Cysteine desulfurase
HPY05_08475	ENOG4105C3M	thioredoxin reductase
HPY05_08480	ENOG4108JJ9	ABC, transporter
HPY05_08485	ENOG4108JJ8	(ABC) transporter
HPY05_08490	ENOG4105FE9	pseudouridine synthase
HPY05_08495	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPY05_08500	ENOG4105DB7	PHP domain protein
HPY05_08510	ENOG4105CRQ	synthase (Component I)
HPY05_08515	ENOG4105DDQ	anthranilate synthase
HPY05_08520	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPY05_08525	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPY05_08530	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPY05_08535	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPY05_08540	ENOG4105CK2	sodium dicarboxylate symporter
HPY05_08545	ENOG4107104	thymidine kinase
HPY05_08550	ENOG4105C9M	aspartyl-trna synthetase
HPY05_08555	ENOG41081XQ	Conserved Protein
HPY05_08560	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HPY05_08565	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HPY05_08570	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY05_08585	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPY05_08595	ENOG4105CUX	Signal transduction histidine kinase
HPY05_08620	ENOG4105DWU	Membrane
HPY05_08630	ENOG4105DY8	decarboxylase
HPY05_08635	ENOG4106KNT	transcriptional regulator
HPY05_08640	ENOG4105C0A	alcohol dehydrogenase
HPY05_08645	ENOG41090BQ	Glutaredoxin
HPY05_08650	ENOG4105D0C	transport protein
HPY05_08655	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY05_08660	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPY05_08665	ENOG4105VEQ	Cold shock protein
HPY05_08675	ENOG4108R99	pseudouridine synthase
HPY05_08680	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HPY05_08685	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPY05_08690	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY05_08695	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HPY05_08700	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPY05_08705	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPY05_08710	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPY05_08715	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPY05_08720	ENOG4107S6Z	Na H antiporter
HPY05_08730	ENOG4107RE1	Inosine-guanosine kinase
HPY05_08735	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPY05_08740	ENOG41075W9	High frequency lysogenization protein HflD homolog
HPY05_08745	ENOG4107QTF	adenylosuccinate lyase
HPY05_08755	ENOG4105RHG	
HPY05_08765	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HPY05_08780	ENOG4107FW0	short-chain dehydrogenase reductase
HPY05_08790	ENOG4105D0M	Protease HtpX homolog
HPY05_08800	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HPY05_08805	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HPY05_08810	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY05_08815	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HPY05_08820	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HPY05_08825	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPY05_08830	ENOG4105D1H	recombination factor protein RarA
HPY05_08840	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY05_08845	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HPY05_08850	ENOG4105BZU	Histidine kinase
HPY05_08855	ENOG4108JJB	ABC transporter
HPY05_08860	ENOG4105C7J	ABC transporter, permease
HPY05_08870	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY05_08875	ENOG4105PQ6	UPF0208 membrane protein
HPY05_08880	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY05_08885	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HPY05_08890	ENOG4105CHF	Glutathione S-transferase
HPY05_08895	ENOG4108JQ7	(ABC) transporter
HPY05_08900	ENOG4105C3U	ABC transporter
HPY05_08905	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY05_08910	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY05_08915	ENOG4107QSI	ABC, transporter
HPY05_08930	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_08935	ENOG4105BZU	Histidine kinase
HPY05_08940	ENOG4105BZU	Histidine kinase
HPY05_08945	ENOG4105BZU	Histidine kinase
HPY05_08955	ENOG4107YTP	response regulator receiver protein
HPY05_08970	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY05_08985	ENOG4108RS6	transposase
HPY05_08995	ENOG4108V1U	phospholipid-binding protein
HPY05_09020	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY05_09025	ENOG41082YX	Transcriptional regulator, arsr family
HPY05_09035	ENOG4105BZU	Histidine kinase
HPY05_09055	ENOG4105C29	acyl-CoA thioesterase
HPY05_09060	ENOG4108XM1	transcriptional regulator AsnC family
HPY05_09070	ENOG4105ERU	peptidase
HPY05_09075	ENOG4105UBK	short-chain dehydrogenase reductase
HPY05_09085	ENOG4108ZZ3	UPF0260 protein
HPY05_09090	ENOG4105KRS	Proteinase inhibitor
HPY05_09100	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HPY05_09105	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HPY05_09110	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPY05_09115	ENOG4105WD1	Membrane
HPY05_09120	ENOG4105I93	response regulator
HPY05_09125	ENOG4105EJC	lysr family transcriptional regulator
HPY05_09130	ENOG41069NU	Nitroreductase
HPY05_09135	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY05_09140	ENOG4105CHU	acetyl-coa acetyltransferase
HPY05_09155	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY05_09160	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY05_09170	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HPY05_09175	ENOG4108GAE	asmA family
HPY05_09180	ENOG4105DBI	uridine monophosphokinase
HPY05_09185	ENOG4105D1F	ATP-binding protein
HPY05_09190	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPY05_09200	ENOG4108I5U	Uridine phosphorylase
HPY05_09215	ENOG4105BZU	Histidine kinase
HPY05_09220	ENOG4108ZAF	Molybdopterin
HPY05_09225	ENOG4105M00	molybdopterin converting factor, subunit 1
HPY05_09230	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY05_09235	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HPY05_09240	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY05_09245	ENOG4105CHW	UPF0052 protein
HPY05_09255	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_09260	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HPY05_09275	ENOG4108R3D	Electron transport complex
HPY05_09295	ENOG4105DZB	Electron transport complex
HPY05_09300	ENOG4105CSM	endonuclease III
HPY05_09305	ENOG4108UYE	Lactoylglutathione lyase
HPY05_09310	ENOG4106WH9	Protein of unknown function (DUF2753)
HPY05_09315	ENOG4105EIY	sodium-type flagellar protein motY
HPY05_09320	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HPY05_09325	ENOG4105D3Y	Na H antiporter
HPY05_09330	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HPY05_09335	ENOG4105E96	Colicin v production protein
HPY05_09340	ENOG4108S3P	Sporulation domain protein
HPY05_09345	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPY05_09350	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HPY05_09355	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPY05_09370	ENOG4105CI1	PTS System
HPY05_09375	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY05_09380	ENOG4105E2R	ROK family
HPY05_09385	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPY05_09390	ENOG4105CAQ	asparagine synthetase
HPY05_09395	ENOG4105MDZ	Transcriptional activator rfaH
HPY05_09400	ENOG4105DUX	Transporter
HPY05_09405	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPY05_09410	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPY05_09415	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HPY05_09420	ENOG4108TU9	TRANSCRIPTIONal
HPY05_09435	ENOG4108RE9	Phosphodiesterase
HPY05_09440	ENOG4105ECP	epimerase
HPY05_09445	ENOG4105E1F	short-chain dehydrogenase reductase
HPY05_09450	ENOG4107QR8	Thioredoxin
HPY05_09455	ENOG4107QX8	SPFH domain, Band 7 family protein
HPY05_09460	ENOG4105G5H	Membrane
HPY05_09465	ENOG4108Z6Z	Transcriptional regulator
HPY05_09475	ENOG41081QG	Porin Gram-negative type
HPY05_09480	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPY05_09490	ENOG4105EXN	Sulfate transport protein CysZ
HPY05_09495	ENOG4105C6T	cysteine synthase
HPY05_09500	ENOG4105KZ7	phosphocarrier protein hpr
HPY05_09505	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPY05_09510	ENOG4105C5Y	PTS System
HPY05_09515	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY05_09520	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HPY05_09525	ENOG4105C9A	Phoh family
HPY05_09530	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HPY05_09535	ENOG4108JU5	Magnesium and cobalt efflux protein
HPY05_09540	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HPY05_09545	ENOG4107PAI	alpha helical protein
HPY05_09550	ENOG4105C8T	Leucyl-tRNA synthetase
HPY05_09555	ENOG4108U2H	Rare lipoprotein B
HPY05_09560	ENOG4105DJF	DNA polymerase III, delta' subunit
HPY05_09565	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HPY05_09570	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HPY05_09575	ENOG4105CJN	penicillin-binding protein
HPY05_09580	ENOG4105CNI	cell division protein FtsW
HPY05_09585	ENOG4105K6T	rare lipoprotein A
HPY05_09590	ENOG4105DZ1	carboxypeptidase
HPY05_09595	ENOG4108Z43	UPF0250 protein
HPY05_09600	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HPY05_09605	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPY05_09615	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY05_09635	ENOG4105D75	Capsular exopolysaccharide family
HPY05_09640	ENOG4105DAY	polysaccharide export protein
HPY05_09650	ENOG4105D3Q	Sugar transferase
HPY05_09665	ENOG4108MA4	Peptidase M66
HPY05_09680	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HPY05_09690	ENOG4105Q84	sucrose synthase
HPY05_09700	ENOG4105D7W	serine acetyltransferase
HPY05_09720	ENOG4108UW5	maltose o-acetyltransferase
HPY05_09730	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY05_09735	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
HPY05_09740	ENOG4105BZS	acriflavin resistance protein
HPY05_09775	ENOG4105C5Y	PTS System
HPY05_09780	ENOG4105D4X	repressor
HPY05_09785	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HPY05_09790	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HPY05_09795	ENOG4108UMI	ABC transporter, permease
HPY05_09800	ENOG4105D01	(LipO)protein
HPY05_09805	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HPY05_09810	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HPY05_09815	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HPY05_09825	ENOG4105BZU	Histidine kinase
HPY05_09830	ENOG4105EWT	decarboxylase family
HPY05_09835	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HPY05_09840	ENOG4105M08	Membrane
HPY05_09845	ENOG4105ETT	transcriptional Regulator, LysR family
HPY05_09850	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HPY05_09855	ENOG4106VK6	Flagellar motor protein
HPY05_09860	ENOG4105E14	MotA TolQ exbB proton channel
HPY05_09870	ENOG4105CTB	Polyprenyl synthetase
HPY05_09875	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HPY05_09880	ENOG4105DR9	pseudouridine synthase
HPY05_09885	ENOG4105WP7	tRNA pseudouridine synthase C
HPY05_09900	ENOG4108428	Inherit from COG: -acetyltransferase
HPY05_09910	ENOG4108UPT	UPF0178 protein
HPY05_09915	ENOG4105CFC	Transporter
HPY05_09925	ENOG4105NRA	50s ribosomal protein l31 type b
HPY05_09930	ENOG4108R96	Methyltransferase, YaeB family
HPY05_09935	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPY05_09955	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPY05_09965	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPY05_09970	ENOG4108Z6B	deaminase
HPY05_09975	ENOG4105CFC	Transporter
HPY05_10005	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY05_10010	ENOG4105CFG	Acts as a chaperone (By similarity)
HPY05_10015	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY05_10020	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPY05_10025	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPY05_10030	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY05_10035	ENOG4105VDB	UPF0125 protein
HPY05_10040	ENOG4108Z1B	Cyclase dehydrase
HPY05_10045	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPY05_10140	ENOG4105DZ0	fad dependent oxidoreductase
HPY05_10145	ENOG4108Z4U	Ferredoxin
HPY05_10170	ENOG4105CHY	citrate lyase, alpha
HPY05_10175	ENOG4105CI0	Citrate lyase
HPY05_10185	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
HPY05_10190	ENOG4105D2K	citrate carrier protein
HPY05_10200	ENOG4107QSA	Oxaloacetate decarboxylase
HPY05_10205	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY05_10210	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY05_10215	ENOG4106YYS	transcriptional regulatory protein
HPY05_10240	ENOG4105BZG	amino acid carrier protein
HPY05_10245	ENOG4105EUZ	Beta-lactamase domain protein
HPY05_10250	ENOG41064T2	transcriptional regulator, lysR family
HPY05_10260	ENOG4105E0A	ABC, transporter
HPY05_10265	ENOG4105TVJ	transport system, permease
HPY05_10270	ENOG4105DQ5	transport system permease protein
HPY05_10275	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HPY05_10285	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HPY05_10290	ENOG4105E4F	Isochorismate synthase
HPY05_10295	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY05_10300	ENOG4105WQI	isochorismatase
HPY05_10305	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HPY05_10315	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HPY05_10325	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPY05_10330	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY05_10335	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPY05_10350	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPY05_10355	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY05_10360	ENOG4105N21	Membrane
HPY05_10365	ENOG4105CUT	histidyl-tRNA synthetase
HPY05_10370	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPY05_10380	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HPY05_10385	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HPY05_10390	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY05_10395	ENOG4105WVQ	Fe-S assembly protein IscX
HPY05_10400	ENOG4108ZIT	Ferredoxin, 2FE-2S
HPY05_10415	ENOG4108Z4V	iron-sulfur cluster assembly
HPY05_10420	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HPY05_10430	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HPY05_10435	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HPY05_10440	ENOG4105ECY	inositol monophosphatase
HPY05_10445	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY05_10450	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY05_10455	ENOG4105VIE	preprotein translocase, subunit YajC
HPY05_10465	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HPY05_10470	ENOG4105W87	Cbs domain
HPY05_10475	ENOG4108I9X	Isocitrate lyase
HPY05_10480	ENOG4107QP3	malate synthase g
HPY05_10485	ENOG4105C5Q	Transcriptional regulator
HPY05_10490	ENOG4105D3R	alkyl hydroperoxide reductase
HPY05_10495	ENOG4106N3A	copper homeostasis protein cutc
HPY05_10500	ENOG4105CSR	polyphosphate kinase 2
HPY05_10510	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY05_10515	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY05_10520	ENOG4105C8U	phosphate abc transporter
HPY05_10525	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HPY05_10530	ENOG4105C9X	ppx gppa phosphatase
HPY05_10535	ENOG4105DJH	phosphate
HPY05_10540	ENOG4105BZU	Histidine kinase
HPY05_10545	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY05_10555	ENOG4105CFP	Peptidase U32
HPY05_10560	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HPY05_10605	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY05_10610	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPY05_10615	ENOG4105C34	Pseudouridine synthase
HPY05_10620	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY05_10625	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HPY05_10635	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
HPY05_10640	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY05_10650	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
HPY05_10655	ENOG4107SC1	transglycosylase
HPY05_10660	ENOG4105C5H	ABC transporter
HPY05_10675	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY05_10680	ENOG4108HRK	Histidine kinase
HPY05_10685	ENOG4108NEV	two component transcriptional regulator, LytTR family
HPY05_10695	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HPY05_10700	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY05_10720	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPY05_10725	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HPY05_10730	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HPY05_10740	ENOG4105DTN	riboflavin biosynthesis protein ribF
HPY05_10745	ENOG4105CJR	Integral membrane protein (MviN
HPY05_10750	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HPY05_10755	ENOG41080HT	Transcriptional regulator, arsr family
HPY05_10760	ENOG41063Z6	transcriptional regulator, lysR family
HPY05_10770	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HPY05_10775	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPY05_10780	ENOG4105HF0	Membrane
HPY05_10785	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HPY05_10790	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPY05_10795	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
HPY05_10800	ENOG4105CPC	Aldo Keto reductase
HPY05_10810	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_10815	ENOG4105CRK	lysyL-tRNA synthetase
HPY05_10825	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPY05_10835	ENOG4105C1J	atp-dependent rna helicase
HPY05_10845	ENOG4105BZU	Histidine kinase
HPY05_10860	ENOG4108YYD	acetyltransferase
HPY05_10870	ENOG4105BZU	Histidine kinase
HPY05_10905	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HPY05_10915	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HPY05_10920	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPY05_10925	ENOG4105CHV	Transcription elongation factor NusA
HPY05_10930	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HPY05_10945	ENOG4105NTZ	Preprotein translocase subunit SecG
HPY05_10955	ENOG4105EEI	dihydropteroate synthase
HPY05_10960	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPY05_10965	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HPY05_10970	ENOG4105HBR	Rna-binding protein
HPY05_10975	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPY05_10980	ENOG4105FCK	Membrane
HPY05_10985	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HPY05_10990	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY05_10995	ENOG4105DR5	peptidase
HPY05_11010	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HPY05_11015	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPY05_11020	ENOG4105IPI	Membrane
HPY05_11025	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY05_11035	ENOG4107QRA	Extracellular solute-binding protein, family 5
HPY05_11045	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY05_11050	ENOG4105C3U	ABC transporter
HPY05_11055	ENOG4108JQ7	(ABC) transporter
HPY05_11065	ENOG4105RD7	BadF BadG BcrA BcrD
HPY05_11070	ENOG4105E2D	ec 3.2.1.52
HPY05_11075	ENOG4105E2V	Glycosyltransferase 36
HPY05_11085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY05_11110	ENOG4105XTV	UPF0231 protein
HPY05_11115	ENOG4107QIJ	Aconitate hydratase 2
HPY05_11120	ENOG4105D78	K07001 NTE family protein
HPY05_11125	ENOG4105BZ4	penicillin-binding protein
HPY05_11130	ENOG4105CQ7	ATP-dependent helicase
HPY05_11140	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HPY05_11145	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPY05_11150	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HPY05_11155	ENOG4105DJ0	Poly(A) Polymerase
HPY05_11160	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY05_11165	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPY05_11170	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPY05_11175	ENOG4105E3A	(ABC) transporter
HPY05_11180	ENOG4105DA5	(ABC) transporter
HPY05_11185	ENOG4105CHH	sulfate transporter
HPY05_11190	ENOG41077A9	carbonic anhydrase
HPY05_11195	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPY05_11200	ENOG410630P	Transcriptional regulator
HPY05_11205	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HPY05_11210	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HPY05_11215	ENOG41082RQ	UPF0102 protein
HPY05_11220	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY05_11225	ENOG4105W4M	Transport-associated protein
HPY05_11230	ENOG4105KB2	stringent starvation protein b
HPY05_11235	ENOG4107MKT	Stringent starvation protein a
HPY05_11240	ENOG4105EIX	cytochrome c1
HPY05_11250	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY05_11255	ENOG4108UJD	30S ribosomal protein S9
HPY05_11260	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPY05_11265	ENOG4105D6Z	AFG1 family ATPase
HPY05_11275	ENOG4105C0H	protease
HPY05_11280	ENOG4105C0H	protease
HPY05_11285	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HPY05_11290	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPY05_11295	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPY05_11300	ENOG4105K5M	30s ribosomal protein S16
HPY05_11305	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY05_11310	ENOG4106KVJ	cytochrome C assembly protein
HPY05_11315	ENOG4108JU6	CBS domain protein
HPY05_11320	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPY05_11325	ENOG4105D9M	gamma-glutamylcysteine synthetase
HPY05_11335	ENOG4105W39	Membrane
HPY05_11345	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY05_11350	ENOG4107QSA	Oxaloacetate decarboxylase
HPY05_11400	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HPY05_11405	ENOG4105CFH	Aspartokinase
HPY05_11410	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPY05_11420	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPY05_11430	ENOG4108IJ6	ABC transporter
HPY05_11435	ENOG4105ECW	sulfate abc transporter
HPY05_11440	ENOG4108I5D	sulfate abc transporter
HPY05_11445	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY05_11450	ENOG4105C6T	cysteine synthase
HPY05_11455	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HPY05_11460	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY05_11465	ENOG4108K5P	(LipO)protein
HPY05_11470	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HPY05_11475	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HPY05_11480	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HPY05_11485	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPY05_11490	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPY05_11500	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPY05_11505	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY05_11510	ENOG4107ZVW	dihydroneopterin aldolase
HPY05_11515	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HPY05_11525	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY05_11530	ENOG4105VCC	30S ribosomal protein S21
HPY05_11535	ENOG4105KTH	gatB Yqey
HPY05_11540	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPY05_11545	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY05_11560	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY05_11565	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HPY05_11570	ENOG410804X	Transcriptional regulator
HPY05_11575	ENOG4105CA9	Pyruvate kinase
HPY05_11580	ENOG4105MPN	Membrane
HPY05_11590	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HPY05_11595	ENOG4105D64	Mechanosensitive ion channel
HPY05_11600	ENOG4105D2N	Aldolase
HPY05_11610	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY05_11615	ENOG4105D05	Receptor
HPY05_11620	ENOG4108R4R	Iron-regulated virulence regulatory protein
HPY05_11625	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY05_11630	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HPY05_11640	ENOG4105RWS	endonuclease I
HPY05_11645	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HPY05_11650	ENOG4105D7Z	glutathione synthase
HPY05_11655	ENOG4108UJU	UPF0301 protein
HPY05_11660	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPY05_11665	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY05_11675	ENOG4105CZX	twitching motility protein
HPY05_11680	ENOG4105CZX	twitching motility protein
HPY05_11685	ENOG4105DFA	alanine racemase domain protein
HPY05_11690	ENOG4105II7	pyrroline-5-carboxylate reductase
HPY05_11695	ENOG4108VIA	integral membrane protein
HPY05_11700	ENOG4105VZ9	UPF0235 protein
HPY05_11710	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HPY05_11715	ENOG4105CSA	Coproporphyrinogen iii oxidase
HPY05_11720	ENOG4105CSV	Glutaminase
HPY05_11725	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HPY05_11730	ENOG4105CEN	a g-specific adenine glycosylase
HPY05_11735	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HPY05_11740	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HPY05_11795	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HPY05_11800	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HPY05_11805	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HPY05_11810	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HPY05_11815	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HPY05_11820	ENOG4105NWN	ApaG protein
HPY05_11825	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HPY05_11835	ENOG4107XM3	UPF0442 protein
HPY05_11840	ENOG4105DWK	Membrane
HPY05_11845	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY05_11850	ENOG4105K46	50S ribosomal protein l27
HPY05_11855	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPY05_11860	ENOG4105EAH	synthase
HPY05_11865	ENOG4105D5Q	Arginine ornithine antiporter
HPY05_11870	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HPY05_11875	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPY05_11880	ENOG4105H1G	trap transporter solute receptor taxi family
HPY05_11890	ENOG41081QV	Universal stress protein
HPY05_11910	ENOG4105CEU	Arginine dihydrolase
HPY05_11915	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HPY05_11925	ENOG4105QD6	exported protein
HPY05_11930	ENOG4105C03	ribonuclease
HPY05_11935	ENOG4108Z03	MAF-like protein
HPY05_11940	ENOG4105VQ7	Rod shape-determining protein MreD
HPY05_11945	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HPY05_11985	ENOG4105X0D	Fimbrial protein
HPY05_11995	ENOG4105D7Q	type ii secretion system
HPY05_12000	ENOG4107QHF	type ii secretion system protein e
HPY05_12035	ENOG41062P1	Diguanylate cyclase phosphodiesterase
HPY05_12040	ENOG4108UUM	single-stranded DNA-binding protein
HPY05_12045	ENOG41086KC	Transcriptional regulator
HPY05_12050	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HPY05_12055	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HPY05_12065	ENOG4105C5R	Aminotransferase
HPY05_12070	ENOG4105CFH	Aspartokinase
HPY05_12075	ENOG4105C3R	Methionine synthase
HPY05_12080	ENOG4105EEQ	Na H antiporter
HPY05_12115	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPY05_12125	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HPY05_12145	ENOG4105P4Z	Phage shock protein G
HPY05_12150	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY05_12155	ENOG4105MYN	Zinc uptake regulation protein
HPY05_12170	ENOG4107QP8	phosphohexose isomerase
HPY05_12175	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HPY05_12180	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY05_12185	ENOG4105CDU	Replicative dna helicase
HPY05_12195	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPY05_12200	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPY05_12205	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HPY05_12210	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPY05_12215	ENOG4108UQY	Iron-storage protein
HPY05_12220	ENOG4105W53	bacterioferritin-associated ferredoxin
HPY05_12225	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY05_12230	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY05_12235	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPY05_12250	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPY05_12255	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HPY05_12260	ENOG4105WWK	YheO domain protein
HPY05_12265	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY05_12275	ENOG41069P5	Protein slyX homolog
HPY05_12285	ENOG4105EPW	hflc protein
HPY05_12290	ENOG4107QJR	hflk protein
HPY05_12295	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPY05_12300	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HPY05_12305	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPY05_12310	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HPY05_12315	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HPY05_12320	ENOG4105K8N	protein family UPF0079, ATPase
HPY05_12325	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HPY05_12375	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPY05_12380	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPY05_12385	ENOG4105DJ4	phosphatidylserine decarboxylase
HPY05_12390	ENOG4105C8P	)-transporter
HPY05_12400	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPY05_12405	ENOG41063SB	peptidase
HPY05_12415	ENOG41062JF	Transcriptional regulator
HPY05_12420	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HPY05_12425	ENOG4105E09	nadh pyrophosphatase
HPY05_12430	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HPY05_12435	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY05_12440	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY05_12445	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HPY05_12450	ENOG4108VZM	50s ribosomal protein L10
HPY05_12460	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HPY05_12465	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPY05_12470	ENOG4105PM1	preprotein translocase subunit SecE
HPY05_12475	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY05_12500	ENOG4105CS9	pantothenic acid kinase
HPY05_12505	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPY05_12510	ENOG4105D4A	Cell wall formation (By similarity)
HPY05_12520	ENOG4105JIM	Phosphatidylserine synthase
HPY05_12590	ENOG4107QK7	reductase
HPY05_12600	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HPY05_12610	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HPY05_12620	ENOG4105C1J	atp-dependent rna helicase
HPY05_12625	ENOG4105C9X	ppx gppa phosphatase
HPY05_12630	ENOG4105BZU	Histidine kinase
HPY05_12635	ENOG4105D8G	Major Facilitator superfamily
HPY05_12650	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY05_12655	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HPY05_12660	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HPY05_12665	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HPY05_12670	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY05_12675	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY05_12680	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HPY05_12685	ENOG4105DIQ	Transcriptional regulator
HPY05_12695	ENOG4105EWV	Sodium calcium exchanger membrane region
HPY05_12700	ENOG4105C01	Dihydroxy-acid dehydratase
HPY05_12705	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPY05_12710	ENOG4105C6Z	Gluconate
HPY05_12715	ENOG4108UHU	Aldolase
HPY05_12720	ENOG4105E0K	tonB-dependent siderophore receptor
HPY05_12735	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_12740	ENOG4105CXN	decarboxylase
HPY05_12745	ENOG4105D5Q	Arginine ornithine antiporter
HPY05_12750	ENOG4108M3R	transcriptional activator CadC
HPY05_12755	ENOG4105W1Y	Transcriptional regulator
HPY05_12770	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPY05_12780	ENOG4105K70	DNA-binding protein
HPY05_12790	ENOG4105R2J	Conserved Protein
HPY05_12795	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HPY05_12800	ENOG4108RG0	uracil-dna glycosylase
HPY05_12805	ENOG4105CUY	Mechanosensitive ion channel
HPY05_12810	ENOG4105CY0	Metallo-Beta-Lactamase
HPY05_12815	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY05_12825	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY05_12845	ENOG4107V1M	polysaccharide export protein
HPY05_12860	ENOG41090SZ	ABC-2 type transporter
HPY05_12865	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY05_12885	ENOG4108MDC	(LipO)protein
HPY05_12895	ENOG4105E3R	(LipO)protein
HPY05_12910	ENOG4105D3Q	Sugar transferase
HPY05_12930	ENOG4105CKK	Glycosyl transferase, family 2
HPY05_12955	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY05_12965	ENOG4105C5E	polysaccharide biosynthesis protein
HPY05_12970	ENOG4108TMJ	glycosyl transferase
HPY05_13000	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HPY05_13005	ENOG4107T94	Endo-14-beta-xylanase
HPY05_13025	ENOG4105XA0	heptosyltransferase ii
HPY05_13030	ENOG4108ST3	glycosyltransferase
HPY05_13035	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HPY05_13060	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
HPY05_13065	ENOG4105DKP	glycosyl transferase, family 9
HPY05_13070	ENOG4106WTF	Glycosyl transferase, family 2
HPY05_13075	ENOG4105M5K	heptosyltransferase
HPY05_13080	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPY05_13085	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPY05_13095	ENOG4105W0E	50S ribosomal protein L33
HPY05_13100	ENOG4105KDC	50s ribosomal protein l28
HPY05_13105	ENOG4105W5Q	DNA repair protein (RadC
HPY05_13110	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_13115	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HPY05_13125	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HPY05_13130	ENOG4105D1S	lipid A biosynthesis
HPY05_13135	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HPY05_13140	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPY05_13145	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPY05_13150	ENOG4105DSJ	YicC domain protein
HPY05_13155	ENOG4108TEB	UPF0114 protein
HPY05_13160	ENOG4105FCK	Membrane
HPY05_13165	ENOG4105C5Y	PTS System
HPY05_13170	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY05_13175	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HPY05_13185	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPY05_13190	ENOG4105FR1	rard protein
HPY05_13195	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY05_13200	ENOG4108DMH	HTH_ARAC
HPY05_13205	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY05_13210	ENOG4105C4R	Atp-dependent dna helicase
HPY05_13215	ENOG4105DGW	oligopeptidase A
HPY05_13220	ENOG4105D6S	protein involved in catabolism of external DNA
HPY05_13225	ENOG4105DC8	reductase
HPY05_13235	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY05_13240	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY05_13245	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPY05_13285	ENOG4105MPD	Cytochrome
HPY05_13290	ENOG4105C4R	Atp-dependent dna helicase
HPY05_13295	ENOG4105Y7M	Transcriptional regulator, TetR family
HPY05_13300	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPY05_13305	ENOG4105BZS	acriflavin resistance protein
HPY05_13310	ENOG4105W0Z	cytoplasmic protein
HPY05_13315	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HPY05_13320	ENOG4105EMY	transcriptional regulator
HPY05_13390	ENOG4108RR8	protoporphyrinogen oxidase
HPY05_13395	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY05_13400	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPY05_13405	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY05_13410	ENOG4105CHU	acetyl-coa acetyltransferase
HPY05_13415	ENOG4105F52	Transcriptional regulator
HPY05_13420	ENOG4105CZQ	inner membrane transport protein YdhC
HPY05_13430	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPY05_13435	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPY05_13440	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPY05_13445	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPY05_13450	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY05_13455	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY05_13465	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPY05_13470	ENOG410684E	atp synthase
HPY05_13475	ENOG4105FA0	parb-like partition protein
HPY05_13480	ENOG4107QJE	Chromosome Partitioning Protein
HPY05_13485	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPY05_13490	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HPY05_13495	ENOG4105QTB	Flavodoxin
HPY05_13500	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HPY05_13505	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPY05_13515	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HPY05_13530	ENOG4105E5Q	amino acid AbC transporter
HPY05_13535	ENOG4105EAB	amino acid AbC transporter
HPY05_13540	ENOG4106RMF	ParB family
HPY05_13570	ENOG4105CDY	transcriptional regulatory protein
HPY05_13575	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPY05_13580	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_13585	ENOG4108YYI	Protein of unknown function (DUF2810)
HPY05_13590	ENOG41061ZR	Transcriptional regulator
HPY05_13595	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HPY05_13600	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HPY05_13605	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPY05_13610	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY05_13615	ENOG4105CS6	Rhs element vgr protein
HPY05_13640	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY05_13650	ENOG4105C8P	)-transporter
HPY05_13655	ENOG4108Q67	UPF0319 protein
HPY05_13685	ENOG4105EYK	Phosphatidylglycerophosphatase B
HPY05_13695	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HPY05_13720	ENOG4105D6U	Sodium Glutamate Symporter
HPY05_13725	ENOG4105YE1	PilZ domain
HPY05_13740	ENOG4105EFX	secretion protein, HlyD family
HPY05_13745	ENOG4105KK7	inner membrane protein YiaW
HPY05_13750	ENOG4106TD9	Diguanylate cyclase
HPY05_13765	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY05_13770	ENOG4107SEY	Conserved Protein
HPY05_13780	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY05_13785	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HPY05_13795	ENOG4105C1J	atp-dependent rna helicase
HPY05_13800	ENOG4105CUG	Oligopeptidase b
HPY05_13830	ENOG4105CVA	phosphate
HPY05_13835	ENOG4105C8U	phosphate abc transporter
HPY05_13840	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY05_13845	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY05_13860	ENOG4105DWD	nucleoside recognition domain protein
HPY05_13865	ENOG4105CHH	sulfate transporter
HPY05_13875	ENOG4105DR5	peptidase
HPY05_13880	ENOG4105BZU	Histidine kinase
HPY05_13885	ENOG4105EQ2	LysR family Transcriptional regulator
HPY05_13890	ENOG4105E5M	Multidrug resistance protein D
HPY05_13895	ENOG4108Z4X	TRANSCRIPTIONal
HPY05_13910	ENOG4105CK2	sodium dicarboxylate symporter
HPY05_13960	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HPY05_13965	ENOG4105D9R	oxidoreductase
HPY05_13975	ENOG4105BZU	Histidine kinase
HPY05_13980	ENOG4107VXZ	Hydrolase
HPY05_13990	ENOG4105D3G	Pseudouridine synthase
HPY05_14050	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY05_14055	ENOG4108JUB	Transcriptional regulator
HPY05_14095	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HPY05_14100	ENOG4105C2J	ABC transporter
HPY05_14105	ENOG4105CNN	ABC, transporter
HPY05_14110	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPY05_14115	ENOG4108RVA	ribokinase
HPY05_14120	ENOG4105ETE	Transcriptional regulator (LacI family
HPY05_14125	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HPY05_14130	ENOG4108I5U	Uridine phosphorylase
HPY05_14150	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPY05_14155	ENOG4105CXY	transporter
HPY05_14170	ENOG4105CQZ	Histidine kinase
HPY05_14175	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY05_14190	ENOG4105D5U	fad dependent oxidoreductase
HPY05_14200	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPY05_14205	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY05_14210	ENOG4105KJM	monovalent cation h antiporter subunit g
HPY05_14215	ENOG41080TA	Multiple resistance and ph regulation protein f
HPY05_14220	ENOG4105SC1	monovalent cation H antiporter subunit E
HPY05_14225	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HPY05_14230	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HPY05_14235	ENOG4105D65	subunit l
HPY05_14245	ENOG4105Q9Y	Universal stress protein
HPY05_14250	ENOG4105CIC	tryptophan-specific transport protein
HPY05_14265	ENOG4105VRT	cytoplasmic protein
HPY05_14275	ENOG4105BZU	Histidine kinase
HPY05_14280	ENOG4105VEQ	Cold shock protein
HPY05_14295	ENOG4107QVM	von Willebrand factor, type A
HPY05_14315	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPY05_14320	ENOG41069D7	Methyl-accepting chemotaxis
HPY05_14335	ENOG4105D9N	nucleoside
HPY05_14340	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY05_14350	ENOG4108JUA	Transcriptional regulator
HPY05_14355	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY05_14360	ENOG4105VEQ	Cold shock protein
HPY05_14380	ENOG4108UNF	response regulator
HPY05_14390	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HPY05_14395	ENOG4105C5I	Dehydrogenase
HPY05_14415	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY05_14430	ENOG4108RS6	transposase
HPY05_14440	ENOG4105C1J	atp-dependent rna helicase
HPY05_14445	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY05_14450	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HPY05_14455	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HPY05_14460	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY05_14480	ENOG4107S6Z	Na H antiporter
HPY05_14485	ENOG4105E5M	Multidrug resistance protein D
HPY05_14495	ENOG4105BZU	Histidine kinase
HPY05_14500	ENOG4105KUU	lipolytic protein G-D-S-L family
HPY05_14505	ENOG4106M3D	hemolysin
HPY05_14510	ENOG4108N3W	hemolysin secretion protein
HPY05_14515	ENOG4107IFA	Lipase (EC 3.1.1.3)
HPY05_14545	ENOG4105DHS	permease protein
HPY05_14550	ENOG4105CM4	permease protein
HPY05_14555	ENOG4108IPW	abc transporter atp-binding protein
HPY05_14575	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY05_14580	ENOG41082YX	Transcriptional regulator, arsr family
HPY05_14585	ENOG4105D6J	arsenicaL-resistance protein
HPY05_14605	ENOG4105CR8	Transcriptional regulator
HPY05_14620	ENOG4105ETX	regulatoR
HPY05_14650	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HPY05_14660	ENOG410667J	hydrolase
HPY05_14705	ENOG4105CHJ	isochorismatase hydrolase
HPY05_14710	ENOG4105C2I	pirin domain protein
HPY05_14715	ENOG4105EGI	Transcriptional regulator
HPY05_14740	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY05_14745	ENOG4105BZU	Histidine kinase
HPY05_14765	ENOG4107QVI	Methyltransferase, type 11
HPY05_14780	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HPY05_14785	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_14795	ENOG4105DZ1	carboxypeptidase
HPY05_14815	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY05_14820	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HPY05_14825	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY05_14845	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPY05_14850	ENOG41082NX	50s ribosomal protein l35
HPY05_14855	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPY05_14935	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY05_15030	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY05_15065	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY05_15095	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY05_15395	ENOG4108EF6	Proline imino-peptidase
HPY05_15400	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY05_15500	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY05_15550	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY05_15560	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY05_15610	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY05_15670	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HPY05_15880	ENOG4105VXN	addiction module toxin, RelE StbE family
HPY05_15940	ENOG4105EST	Metal Dependent Phosphohydrolase
HPY05_15965	ENOG4105KD7	acetyltransferase
HPY05_15980	ENOG41080ET	plasmid maintenance system killer protein
HPY05_15985	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
HPY05_16045	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY05_16080	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY05_16165	ENOG4105HHM	rdd domain containing protein
HPY05_16615	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY05_16715	ENOG4108RS6	transposase
HPY05_16720	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY05_16725	ENOG4105CDV	Ompa motb domain protein
HPY05_16730	ENOG4108NVR	Methyl-accepting chemotaxis
HPY05_16735	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPY05_16740	ENOG4105D7K	pfkb domain protein
HPY05_16745	ENOG4108HKT	sucrose-6-phosphate hydrolase
HPY05_16750	ENOG4105ETE	Transcriptional regulator (LacI family
HPY05_16755	ENOG4105C5Y	PTS System
HPY05_16795	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HPY05_16830	ENOG4108RCM	Nitroreductase
HPY05_16835	ENOG41067V3	Antibiotic biosynthesis monooxygenase
HPY05_16840	ENOG4105ETT	transcriptional Regulator, LysR family
HPY05_16850	ENOG4105RA2	Membrane
HPY05_16865	ENOG4108M3J	Dehydrogenase
HPY05_16890	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY05_16900	ENOG4107RHR	regulatoR
HPY05_16905	ENOG4105KHC	sulfurtransferase
HPY05_16915	ENOG4105D06	uba thif-type nad fad binding protein
HPY05_16920	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY05_16925	ENOG4105EUJ	GTP cyclohydrolase i
HPY05_16930	ENOG4105E0X	reductase
HPY05_16935	ENOG4105CKU	formyltetrahydrofolate synthetase
HPY05_16940	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HPY05_16945	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HPY05_16955	ENOG4105JQN	Transcriptional regulator
HPY05_16960	ENOG4105PAD	Hydrolase
HPY05_16965	ENOG4105NXH	GreA GreB family elongation factor
HPY05_16970	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HPY05_16975	ENOG4108JPW	Aminotransferase
HPY05_16980	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HPY05_16995	ENOG4107RCV	ABC transporter, permease
HPY05_17010	ENOG4105DUX	Transporter
HPY05_17035	ENOG4105E43	Extracellular solute-binding protein, family 5
HPY05_17040	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HPY05_17045	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPY05_17050	ENOG4108JQ5	ABC transporter
HPY05_17055	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY05_17070	ENOG4105CYM	Glutathione S-transferase
HPY05_17090	ENOG4105KA0	thioesterase Superfamily protein
HPY05_17105	ENOG4105D05	Receptor
HPY05_17110	ENOG4105CWB	LysR family transcriptional Regulator
HPY05_17115	ENOG4105CD5	CoA-binding domain protein
HPY05_17135	ENOG4108ZJT	translation initiation factor, Sui1
HPY05_17155	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY05_17165	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY05_17170	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY05_17185	ENOG4105BZU	Histidine kinase
HPY05_17195	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY05_17205	ENOG4105BZU	Histidine kinase
HPY05_17235	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HPY05_17245	ENOG4105DU1	integral membrane protein, terc
HPY05_17250	ENOG4105CGH	5'-nucleotidase
HPY05_17255	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
HPY05_17260	ENOG4108UQ5	membrane protein YcdZ
HPY05_17265	ENOG4105DUM	transcriptional regulator, lysR family
HPY05_17270	ENOG4105TMB	Formate nitrite transporter
HPY05_17280	ENOG4105DS1	cytochrome b561
HPY05_17290	ENOG4105EPM	Diguanylate phosphodiesterase
HPY05_17315	ENOG4105C08	Histidine kinase
HPY05_17320	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HPY05_17325	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HPY05_17330	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HPY05_17335	ENOG4105CKI	cobalamin synthesis protein
HPY05_17340	ENOG4105CMQ	Chloride channel
HPY05_17350	ENOG4107KBT	8-Amino-7-oxononanoate synthase
HPY05_17355	ENOG4108MGY	Histidine kinase
HPY05_17360	ENOG4105EYH	Exonuclease
HPY05_17365	ENOG4107RFY	SbcCD D subunit
HPY05_17370	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPY05_17375	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HPY05_17380	ENOG4105DE4	1-phosphofructokinase
HPY05_17385	ENOG4105DM4	PTS System
HPY05_17390	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY05_17395	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY05_17400	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HPY05_17405	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HPY05_17415	ENOG4107VXZ	Hydrolase
HPY05_17420	ENOG4108N3W	hemolysin secretion protein
HPY05_17425	ENOG4105CEE	C4-dicarboxylate transporter
HPY05_17430	ENOG4105EJQ	L-serine dehydratase
HPY05_17435	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY05_17440	ENOG4105BZU	Histidine kinase
HPY05_17455	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY05_17475	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY05_17480	ENOG4108KX4	response regulator
HPY05_17485	ENOG4105BZU	Histidine kinase
HPY05_17490	ENOG4105CXY	transporter
HPY05_17495	ENOG4105C4Y	ABC transporter
HPY05_17500	ENOG4107RCV	ABC transporter, permease
HPY05_17505	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY05_17510	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HPY05_17520	ENOG4105CHU	acetyl-coa acetyltransferase
HPY05_17530	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY05_17535	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY05_17550	ENOG4105BZU	Histidine kinase
HPY05_17555	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY05_17565	ENOG4108I6A	alcohol dehydrogenase
HPY05_17575	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
HPY05_17585	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
HPY05_17590	ENOG4105CXY	transporter
HPY05_17595	ENOG4105CA9	Pyruvate kinase
HPY05_17600	ENOG4105BZU	Histidine kinase
HPY05_17605	ENOG4108SV3	Tmao reductase system periplasmic protein tort
HPY05_17610	ENOG4108Z5K	methylglyoxal synthase
HPY05_17615	ENOG4108RWI	nicotinamidase
HPY05_17620	ENOG41080IJ	Diacylglycerol kinase
HPY05_17625	ENOG41088T4	Helicase IV
HPY05_17630	ENOG4105EM2	membrane
HPY05_17660	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HPY05_17665	ENOG4105E0C	molybdate abc transporter
HPY05_17670	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HPY05_17675	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HPY05_17715	ENOG4105ID8	Transcriptional regulator, ARAC family
HPY05_17725	ENOG4105EYM	Major Facilitator superfamily
HPY05_17755	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY05_17760	ENOG4105C94	Transporter
HPY05_17780	ENOG4105BZ1	(ABC) transporter
HPY05_17785	ENOG4105BZ1	(ABC) transporter
HPY05_17795	ENOG4105BZU	Histidine kinase
HPY05_17800	ENOG4108QGH	periplasmic
HPY05_17810	ENOG41082IR	Excinuclease ABC C subunit domain protein
HPY05_17825	ENOG41090HJ	UPF0265 protein
HPY05_17840	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPY05_17845	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HPY05_17855	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPY05_17860	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY05_17865	ENOG4105K63	Thioredoxin
HPY05_17890	ENOG4105DMR	ABC, transporter
HPY05_17895	ENOG4105GBT	ABC transporter
HPY05_17900	ENOG4106PMH	Extracellular solute-binding protein family 3
HPY05_17905	ENOG4105E5Z	arginine transporter ATP-binding subunit
HPY05_17915	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HPY05_17925	ENOG4108YZ4	nudix hydrolase
HPY05_17930	ENOG4105C5W	Aldolase
HPY05_17935	ENOG4106RE7	Cytochrome
HPY05_17940	ENOG4107XI7	Tetr family transcriptional regulator
HPY05_17945	ENOG4105C1J	atp-dependent rna helicase
HPY05_17950	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HPY05_17955	ENOG4105E0U	tyrosine-specific transport protein
HPY05_17960	ENOG4108N3W	hemolysin secretion protein
HPY05_17965	ENOG4105CMR	udp-glucose 4-epimerase
HPY05_17970	ENOG4105E7W	lamb ycsf family protein
HPY05_17980	ENOG4107R7A	Allophanate hydrolase subunit 2
HPY05_17990	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HPY05_17995	ENOG4105CV6	ABC transporter, permease
HPY05_18000	ENOG4108I0Y	(ABC) transporter
HPY05_18010	ENOG4105RKW	reductase (By
HPY05_18025	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY05_18040	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY05_18055	ENOG4107RE1	Inosine-guanosine kinase
HPY05_18060	ENOG4105E0M	Sulfatase
HPY05_18070	ENOG4105C1J	atp-dependent rna helicase
HPY05_18085	ENOG4105CVA	phosphate
HPY05_18095	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HPY05_18100	ENOG4108M1A	Chitin-binding protein
HPY05_18105	ENOG4105D4Y	metalloprotease
HPY05_18115	ENOG4105CYW	agmatinase
HPY05_18120	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HPY05_18130	ENOG4105CJW	magnesium transporter
HPY05_18135	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY05_18140	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY05_18150	ENOG4105CZK	Aspartate kinase
HPY05_18155	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
HPY05_18160	ENOG4108JPW	Aminotransferase
HPY05_18165	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY05_18170	ENOG41090A4	Pterin carbinolamine dehydratase
HPY05_18175	ENOG4105MIR	Phenylalanine 4-monooxygenase
HPY05_18180	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY05_18195	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY05_18200	ENOG4105EGI	Transcriptional regulator
HPY05_18220	ENOG4105C37	(CBS) domain
HPY05_18225	ENOG4108UKZ	OsmC family
HPY05_18230	ENOG4107YWA	deoxycytidylate deaminase
HPY05_18270	ENOG4106TD9	Diguanylate cyclase
HPY05_18280	ENOG4108VAC	response regulator
HPY05_18285	ENOG4108HRK	Histidine kinase
HPY05_18300	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY05_18305	ENOG4105C19	ABC transporter
HPY05_18315	ENOG4107RGM	aldo keto reductase
HPY05_18320	ENOG4107T9C	Alpha amylase catalytic region
HPY05_18330	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY05_18335	ENOG4108M0H	Extracellular lipase
HPY05_18340	ENOG4107SDU	Methyl-accepting chemotaxis
HPY05_18345	ENOG4105D4Y	metalloprotease
HPY05_18350	ENOG4105EIF	outer membrane protein W
HPY05_18360	ENOG41061WM	D-Alanyl-D-Alanine
HPY05_18365	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY05_18370	ENOG4105VEQ	Cold shock protein
HPY05_18380	ENOG4105BZC	d-serine deaminase
HPY05_18390	ENOG4105W8I	Transcriptional regulator
HPY05_18435	ENOG4107R08	Integrase
HPY05_18455	ENOG4105CPQ	Dehydrogenase
HPY05_18460	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY05_18475	ENOG4105EXG	Transcriptional regulator
HPY05_18480	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HPY05_18500	ENOG4107SSZ	Phosphatase
HPY05_18505	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY05_18510	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HPY05_18515	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HPY05_18520	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPY05_18545	ENOG4105BZW	Glycerate kinase
HPY05_18550	ENOG4105C6Z	Gluconate
HPY05_18555	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HPY05_18560	ENOG4108NVR	Methyl-accepting chemotaxis
HPY05_18565	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HPY05_18570	ENOG41090JE	Utilization Protein
HPY05_18575	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY05_18580	ENOG4105WQ5	TonB family
HPY05_18585	ENOG41090AP	transport protein
HPY05_18590	ENOG4106GFD	transport protein
HPY05_18600	ENOG4105EHG	Permease protein
HPY05_18605	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY05_18635	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_18640	ENOG4105QVC	MOSC domain-containing protein
HPY05_18640	ENOG4105QVC	MOSC domain-containing protein
HPY05_18645	ENOG4105EKE	dihydroorotase
HPY05_18650	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
HPY05_18655	ENOG4105CKW	Inner membrane protein yedI
HPY05_18665	ENOG4108ESY	Metal dependent phosphohydrolase
HPY05_18670	ENOG4105VEQ	Cold shock protein
HPY05_18695	ENOG4105BZU	Histidine kinase
HPY05_18700	ENOG4105E98	transcriptional regulator DeoR family
HPY05_18715	ENOG4105EG2	ABC transporter, permease
HPY05_18720	ENOG4105D56	permease protein
HPY05_18725	ENOG4107FKK	extracellular solute-binding protein family 1
HPY05_18730	ENOG4108IJ9	(ABC) transporter
HPY05_18735	ENOG4108HK0	-acetyltransferase
HPY05_18750	ENOG4105K8R	UPF0145 protein
HPY05_18755	ENOG41086KC	Transcriptional regulator
HPY05_18760	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HPY05_18770	ENOG4105K56	Transcriptional regulator
HPY05_18775	ENOG4106TD9	Diguanylate cyclase
HPY05_18790	ENOG4105BZU	Histidine kinase
HPY05_18810	ENOG4105ETT	transcriptional Regulator, LysR family
HPY05_18815	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY05_18825	ENOG4105EUB	pirin domain protein
HPY05_18830	ENOG4105NBK	UPF0345 protein
HPY05_18840	ENOG4105E5W	Transporter
HPY05_18845	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_18850	ENOG4105DAN	ATP-dependent protease
HPY05_18860	ENOG4108JQ5	ABC transporter
HPY05_18865	ENOG4105E89	ABC transporter
HPY05_18870	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_18880	ENOG4105CC0	LysR family Transcriptional regulator
HPY05_18890	ENOG4105DAA	L-lactate
HPY05_18905	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HPY05_18915	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HPY05_18935	ENOG4108RPX	mosc domain containing protein
HPY05_18940	ENOG4105C1J	atp-dependent rna helicase
HPY05_18950	ENOG4105BZ1	(ABC) transporter
HPY05_18960	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY05_18970	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY05_18995	ENOG4105K56	Transcriptional regulator
HPY05_19000	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HPY05_19010	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY05_19015	ENOG4105VW4	glutaredoxin 3
HPY05_19020	ENOG4108P2H	Inner membrane protein YjiG
HPY05_19025	ENOG41074DU	domain protein
HPY05_19030	ENOG4105DN9	Na H antiporter
HPY05_19040	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPY05_19045	ENOG4105D03	DNA-3-methyladenine glycosylase II
HPY05_19050	ENOG4108VGI	doxx family
HPY05_19075	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPY05_19085	ENOG4107W52	maltose operon periplasmic protein
HPY05_19090	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPY05_19105	ENOG4108N3W	hemolysin secretion protein
HPY05_19120	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_19125	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY05_19135	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY05_19140	ENOG4105CDA	abc transporter atp-binding protein
HPY05_19150	ENOG4106TNF	Periplasmic binding protein
HPY05_19155	ENOG4105EZ7	amino acid ABC transporter
HPY05_19160	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HPY05_19165	ENOG4105CTS	PTS system mannitol-specific
HPY05_19170	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HPY05_19175	ENOG4105E61	Mannitol repressor protein
HPY05_19180	ENOG4105EP9	oxidoreductase
HPY05_19210	ENOG4108RYK	Nad-dependent epimerase dehydratase
HPY05_19215	ENOG4105JQN	Transcriptional regulator
HPY05_19220	ENOG41069D7	Methyl-accepting chemotaxis
HPY05_19225	ENOG4105EMU	Dehydrogenase
HPY05_19230	ENOG4105JQN	Transcriptional regulator
HPY05_19250	ENOG4105D5Q	Arginine ornithine antiporter
HPY05_19255	ENOG4105CXN	decarboxylase
HPY05_19265	ENOG4105VJY	transcriptional regulator
HPY05_19285	ENOG4107RGH	Aldehyde dehydrogenase
HPY05_19290	ENOG4105EW9	transcriptional regulator AsnC family
HPY05_19305	ENOG4105CK7	Sodium proline symporter
HPY05_19330	ENOG4105E6M	Sulphatase-modifying factor protein
HPY05_19345	ENOG4107QZV	Type I secretion membrane fusion protein
HPY05_19360	ENOG4108JJA	ABC, transporter
HPY05_19380	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_19385	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY05_19395	ENOG4105BZU	Histidine kinase
HPY05_19400	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_19405	ENOG4108V3W	Chemotaxis protein, CheW
HPY05_19410	ENOG4108V3W	Chemotaxis protein, CheW
HPY05_19415	ENOG4105CBS	Chea signal transduction histidine kinase
HPY05_19420	ENOG4108VYJ	response regulator receiver protein
HPY05_19430	ENOG4108NY6	Extracellular solute-binding protein, family 5
HPY05_19435	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY05_19440	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY05_19450	ENOG4105DIJ	Phosphoethanolamine transferase
HPY05_19455	ENOG4105DHQ	Histidine kinase
HPY05_19460	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY05_19470	ENOG4105EMU	Dehydrogenase
HPY05_19490	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HPY05_19495	ENOG4107RUE	extracellular solute-binding protein family 1
HPY05_19560	ENOG4105C4R	Atp-dependent dna helicase
HPY05_19790	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY05_19820	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY05_19915	ENOG4105KT5	UmuD protein
HPY05_19935	ENOG4106032	Glutathionylspermidine synthase
HPY05_19955	ENOG4108P9J	Phage shock protein A
HPY05_19975	ENOG4105D13	transposase
HPY05_19990	ENOG4105K4U	addiction module toxin, RelE StbE family
HPY05_20240	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY05_20245	ENOG4105BZU	Histidine kinase
HPY05_20600	ENOG4105DVT	helicase
HPY05_20640	ENOG4105C4R	Atp-dependent dna helicase
HPY05_20675	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY05_20690	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY05_20770	ENOG4105DCY	Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity)
HPY05_20860	ENOG4105C3F	Signal peptidase i
HPY05_20885	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY05_21000	ENOG4105FA0	parb-like partition protein