locus-tag	class	description
HPY05_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY05_00010	COG0592	DNA-directed DNA polymerase activity
HPY05_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY05_00020	COG0187	DNA topoisomerase II activity
HPY05_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY05_00035	COG3977	Valine--pyruvate aminotransferase
HPY05_00040	COG0751	glycine-tRNA ligase activity
HPY05_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY05_00050	COG2119	membrane
HPY05_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY05_00070	COG0604	alcohol dehydrogenase
HPY05_00080	COG0129	dihydroxy-acid dehydratase activity
HPY05_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY05_00100	COG0606	chelatase, subunit chli
HPY05_00105	COG0204	Acyl-transferase
HPY05_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY05_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY05_00125	COG3084	Protein conserved in bacteria
HPY05_00135	COG4326	sporulation control protein
HPY05_00140	COG1272	protein, Hemolysin III
HPY05_00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY05_00155	COG0569	domain protein
HPY05_00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY05_00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY05_00170	COG0242	peptide deformylase activity
HPY05_00175	COG1652	LysM domain
HPY05_00180	COG0758	DNA mediated transformation
HPY05_00185	COG2922	Belongs to the Smg family
HPY05_00190	COG0551	DNA topoisomerase type I activity
HPY05_00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY05_00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY05_00205	COG0009	L-threonylcarbamoyladenylate synthase
HPY05_00210	COG0408	coproporphyrinogen oxidase activity
HPY05_00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY05_00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY05_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY05_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY05_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY05_00280	COG2104	thiamine diphosphate biosynthetic process
HPY05_00285	COG2022	thiamine diphosphate biosynthetic process
HPY05_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY05_00295	COG0006	proline dipeptidase activity
HPY05_00295	COG0006	proline dipeptidase activity
HPY05_00315	COG1522	sequence-specific DNA binding
HPY05_00320	COG5002	protein histidine kinase activity
HPY05_00320	COG5001	Diguanylate cyclase
HPY05_00340	COG0589	response to stress
HPY05_00345	COG1528	Iron-storage protein
HPY05_00355	COG2081	HI0933 family
HPY05_00365	COG1322	Protein conserved in bacteria
HPY05_00370	COG2226	methyltransferase
HPY05_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY05_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY05_00395	COG0805	protein transport
HPY05_00400	COG1858	cytochrome C peroxidase
HPY05_00405	COG0534	Mate efflux family protein
HPY05_00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY05_00420	COG2937	Belongs to the GPAT DAPAT family
HPY05_00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY05_00430	COG3161	chorismate lyase activity
HPY05_00435	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY05_00440	COG0840	transmembrane signaling receptor activity
HPY05_00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY05_00455	COG0084	hydrolase, TatD family'
HPY05_00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY05_00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY05_00490	COG3078	GTPase activator activity
HPY05_00505	COG3071	HemY protein
HPY05_00510	COG2959	enzyme of heme biosynthesis
HPY05_00515	COG1587	Uroporphyrinogen-III synthase
HPY05_00520	COG0181	hydroxymethylbilane synthase activity
HPY05_00530	COG1965	Belongs to the frataxin family
HPY05_00540	COG0019	diaminopimelate decarboxylase activity
HPY05_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY05_00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY05_00560	COG1011	Hydrolase
HPY05_00565	COG3287	FIST C domain
HPY05_00565	COG2199	diguanylate cyclase activity
HPY05_00565	COG2200	EAL domain
HPY05_00580	COG0561	phosphatase activity
HPY05_00585	COG2267	carboxylic ester hydrolase activity
HPY05_00590	COG1280	lysine exporter protein (LysE YggA)
HPY05_00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY05_00600	COG0783	Belongs to the Dps family
HPY05_00630	COG0742	ribosomal rna small subunit methyltransferase
HPY05_00635	COG0552	protein localization to endoplasmic reticulum
HPY05_00640	COG2884	Cell division ATP-binding protein ftsE
HPY05_00645	COG2177	Part of the ABC transporter FtsEX involved in
HPY05_00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY05_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY05_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY05_00680	COG1404	Belongs to the peptidase S8 family
HPY05_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY05_00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY05_00755	COG5001	Diguanylate cyclase
HPY05_00755	COG3300	MHYT domain
HPY05_00765	COG3852	Histidine kinase
HPY05_00775	COG0174	glutamine synthetase
HPY05_00795	COG1295	ribonuclease BN
HPY05_00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY05_00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY05_00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY05_00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY05_00830	COG3031	protein transport across the cell outer membrane
HPY05_00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY05_00845	COG1459	type II secretion system
HPY05_00850	COG2165	general secretion pathway protein
HPY05_00855	COG2165	general secretion pathway protein
HPY05_00860	COG2165	general secretion pathway protein
HPY05_00865	COG4795	General secretion pathway protein
HPY05_00870	COG3156	type II secretion system protein K
HPY05_00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY05_00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY05_00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY05_00895	COG0494	nUDIX hydrolase
HPY05_00905	COG1040	competence protein
HPY05_00915	COG0596	Alpha beta hydrolase
HPY05_00925	COG2183	response to ionizing radiation
HPY05_00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY05_00935	COG2199	diguanylate cyclase activity
HPY05_00940	COG0745	RESPONSE REGULATOR receiver
HPY05_00950	COG2233	PERMEase
HPY05_00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY05_00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY05_00965	COG1758	RNA polymerase activity
HPY05_00970	COG0194	GDP metabolic process
HPY05_00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY05_00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY05_01000	COG4232	protein-disulfide reductase activity
HPY05_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY05_01015	COG1027	Aspartate ammonia-lyase
HPY05_01020	COG3706	GGDEF domain
HPY05_01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY05_01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY05_01040	COG2205	protein histidine kinase activity
HPY05_01045	COG0745	RESPONSE REGULATOR receiver
HPY05_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY05_01060	COG0205	6-phosphofructokinase activity
HPY05_01065	COG1494	fructose-1,6-bisphosphatase
HPY05_01070	COG3074	FtsZ-dependent cytokinesis
HPY05_01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY05_01080	COG0460	homoserine dehydrogenase
HPY05_01080	COG0527	aspartate kinase activity
HPY05_01085	COG0626	cystathionine gamma-synthase activity
HPY05_01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY05_01095	COG0281	malic enzyme
HPY05_01100	COG0254	rRNA binding
HPY05_01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY05_01110	COG1609	Transcriptional regulator
HPY05_01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY05_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY05_01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY05_01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY05_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY05_01140	COG0534	Mate efflux family protein
HPY05_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY05_01175	COG0459	protein refolding
HPY05_01185	COG1509	lysine 2,3-aminomutase activity
HPY05_01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY05_01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY05_01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY05_01210	COG1053	succinate dehydrogenase
HPY05_01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY05_01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY05_01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY05_01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY05_01235	COG1045	serine acetyltransferase
HPY05_01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY05_01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY05_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY05_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY05_01265	COG0137	argininosuccinate synthase activity
HPY05_01270	COG0165	Argininosuccinate lyase
HPY05_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY05_01285	COG0678	peroxiredoxin activity
HPY05_01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY05_01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY05_01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY05_01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY05_01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY05_01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY05_01350	COG0546	phosphoglycolate phosphatase activity
HPY05_01355	COG0180	Tryptophanyl-tRNA synthetase
HPY05_01375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY05_01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY05_01395	COG1012	belongs to the aldehyde dehydrogenase family
HPY05_01410	COG3954	Phosphoribulokinase
HPY05_01420	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY05_01430	COG0488	(ABC) transporter
HPY05_01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY05_01450	COG1047	Peptidyl-prolyl cis-trans
HPY05_01460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY05_01465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY05_01475	COG0557	exoribonuclease II activity
HPY05_01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY05_01485	COG0051	transcription antitermination factor activity, RNA binding
HPY05_01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY05_01495	COG0088	Forms part of the polypeptide exit tunnel
HPY05_01500	COG0089	rRNA binding
HPY05_01505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY05_01510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY05_01515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY05_01520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY05_01525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY05_01530	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY05_01535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY05_01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY05_01545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY05_01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY05_01555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY05_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY05_01565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY05_01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY05_01575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY05_01580	COG1841	ribosomal large subunit assembly
HPY05_01590	COG0201	protein transport
HPY05_01595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY05_01600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY05_01605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY05_01610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY05_01615	COG0202	RNA polymerase activity
HPY05_01620	COG0203	ribosomal protein L17
HPY05_01630	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY05_01635	COG3061	Opacity-associated protein A
HPY05_01635	COG3266	domain, Protein
HPY05_01640	COG0697	spore germination
HPY05_01645	COG2153	protein acetylation
HPY05_01650	COG0513	Belongs to the DEAD box helicase family
HPY05_01660	COG0737	Belongs to the 5'-nucleotidase family
HPY05_01665	COG1648	precorrin-2 dehydrogenase activity
HPY05_01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY05_01670	COG0175	sulfate reduction
HPY05_01675	COG2895	sulfate adenylyltransferase (ATP) activity
HPY05_01680	COG0529	Catalyzes the synthesis of activated sulfate
HPY05_01700	COG1136	(ABC) transporter
HPY05_01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY05_01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY05_01725	COG0729	surface antigen
HPY05_01735	COG2105	PFAM AIG2 family protein
HPY05_01740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY05_01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY05_01755	COG0163	prenyltransferase activity
HPY05_01765	COG1178	ABC-type Fe3 transport system permease component
HPY05_01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY05_01775	COG3028	Belongs to the UPF0307 family
HPY05_01780	COG0312	modulator of DNA gyrase
HPY05_01785	COG2239	Acts as a magnesium transporter
HPY05_01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY05_01795	COG1660	Displays ATPase and GTPase activities
HPY05_01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY05_01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY05_01815	COG1137	ATPase activity
HPY05_01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY05_01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY05_01835	COG0517	IMP dehydrogenase activity
HPY05_01845	COG1127	ABC transporter
HPY05_01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY05_01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY05_01860	COG2854	intermembrane phospholipid transfer
HPY05_01870	COG5007	Belongs to the BolA IbaG family
HPY05_01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY05_01885	COG0251	oxidation-reduction process
HPY05_01895	COG0540	Belongs to the ATCase OTCase family
HPY05_01905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY05_01920	COG0564	pseudouridine synthase activity
HPY05_01925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY05_01930	COG0525	valine-tRNA ligase activity
HPY05_01935	COG2927	DNA polymerase III (CHI subunit)
HPY05_01940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY05_01945	COG0795	lipopolysaccharide-transporting ATPase activity
HPY05_01950	COG0795	lipopolysaccharide-transporting ATPase activity
HPY05_01965	COG3437	response regulator, receiver
HPY05_02005	COG0066	3-isopropylmalate dehydratase activity
HPY05_02010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY05_02015	COG0473	3-isopropylmalate dehydrogenase activity
HPY05_02040	COG0583	DNA-binding transcription factor activity
HPY05_02045	COG1022	Amp-dependent synthetase and ligase
HPY05_02050	COG0028	Belongs to the TPP enzyme family
HPY05_02055	COG0440	acetolactate synthase activity
HPY05_02060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY05_02065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY05_02070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY05_02080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY05_02085	COG3079	Belongs to the UPF0149 family
HPY05_02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY05_02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY05_02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY05_02120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY05_02125	COG1595	DNA-templated transcription, initiation
HPY05_02140	COG3086	response to oxidative stress
HPY05_02145	COG0481	GTPase activity
HPY05_02155	COG0571	ribonuclease III activity
HPY05_02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY05_02165	COG1381	Involved in DNA repair and RecF pathway recombination
HPY05_02170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY05_02175	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY05_02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY05_02210	COG3956	TIGRFAM MazG family protein
HPY05_02215	COG0504	CTP synthase activity
HPY05_02220	COG0148	phosphopyruvate hydratase activity
HPY05_02225	COG0617	tRNA 3'-terminal CCA addition
HPY05_02230	COG3267	Type II secretory pathway component ExeA
HPY05_02230	COG3409	Peptidoglycan-binding domain 1 protein
HPY05_02240	COG4991	sh3 domain protein
HPY05_02245	COG0306	phosphate transporter
HPY05_02250	COG1392	Phosphate transport regulator
HPY05_02255	COG3025	triphosphatase activity
HPY05_02260	COG0840	transmembrane signaling receptor activity
HPY05_02265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY05_02275	COG1538	Outer membrane efflux protein
HPY05_02280	COG0494	nUDIX hydrolase
HPY05_02285	COG3151	Protein conserved in bacteria
HPY05_02295	COG3150	esterase
HPY05_02300	COG0187	DNA topoisomerase II activity
HPY05_02305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY05_02315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY05_02320	COG0237	dephospho-CoA kinase activity
HPY05_02330	COG1459	type II secretion system
HPY05_02335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY05_02355	COG0716	FMN binding
HPY05_02360	COG4974	Belongs to the 'phage' integrase family
HPY05_02365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY05_02370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY05_02375	COG2186	Transcriptional regulator
HPY05_02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY05_02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY05_02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY05_02405	COG3116	cell division
HPY05_02410	COG0768	penicillin binding
HPY05_02415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY05_02420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY05_02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY05_02435	COG0772	Belongs to the SEDS family
HPY05_02440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY05_02445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY05_02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY05_02455	COG0849	cell division
HPY05_02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY05_02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY05_02475	COG0653	protein targeting
HPY05_02480	COG0494	nUDIX hydrolase
HPY05_02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY05_02495	COG0505	Belongs to the CarA family
HPY05_02500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY05_02520	COG0730	response to heat
HPY05_02525	COG0583	DNA-binding transcription factor activity
HPY05_02530	COG2860	membrane
HPY05_02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY05_02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY05_02555	COG0493	'glutamate synthase
HPY05_02560	COG0069	glutamate synthase activity
HPY05_02560	COG0067	glutamate synthase
HPY05_02560	COG0070	glutamate synthase
HPY05_02570	COG0069	glutamate synthase activity
HPY05_02570	COG0067	glutamate synthase
HPY05_02570	COG0070	glutamate synthase
HPY05_02575	COG1242	4 iron, 4 sulfur cluster binding
HPY05_02580	COG2203	Gaf domain
HPY05_02580	COG5001	Diguanylate cyclase
HPY05_02580	COG3706	GGDEF domain
HPY05_02580	COG4251	negative regulation of phosphorylation
HPY05_02585	COG0784	Response regulator, receiver
HPY05_02585	COG5002	protein histidine kinase activity
HPY05_02585	COG2198	Histidine kinase
HPY05_02590	COG0745	RESPONSE REGULATOR receiver
HPY05_02600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY05_02620	COG0083	homoserine kinase activity
HPY05_02625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY05_02630	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY05_02635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY05_02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY05_02655	COG1115	amino acid carrier protein
HPY05_02660	COG3022	response to hydroperoxide
HPY05_02670	COG0084	hydrolase, TatD family'
HPY05_02675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY05_02685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY05_02690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY05_02695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY05_02700	COG0813	purine-nucleoside phosphorylase activity
HPY05_02710	COG0560	Phosphoserine phosphatase
HPY05_02720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY05_02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY05_02730	COG1022	Amp-dependent synthetase and ligase
HPY05_02745	COG3250	beta-galactosidase activity
HPY05_02750	COG1609	Transcriptional regulator
HPY05_02755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY05_02770	COG0189	ligase activity
HPY05_02770	COG0569	domain protein
HPY05_02775	COG0456	acetyltransferase
HPY05_02785	COG2171	N-acyltransferase activity
HPY05_02790	COG3141	response to X-ray
HPY05_02805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY05_02810	COG1074	ATP-dependent DNA helicase activity
HPY05_02815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY05_02825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY05_02825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY05_02835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY05_02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY05_02845	COG2166	iron-sulfur cluster assembly
HPY05_02850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY05_02855	COG0693	protein deglycase activity
HPY05_02860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY05_02865	COG3248	Nucleoside-binding outer membrane protein
HPY05_02875	COG1595	DNA-templated transcription, initiation
HPY05_02885	COG2211	Major facilitator Superfamily
HPY05_02890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY05_02900	COG2813	Specifically methylates the guanine in position
HPY05_02905	COG0271	Belongs to the BolA IbaG family
HPY05_02910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY05_02915	COG1805	sodium ion transport
HPY05_02920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY05_02925	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY05_02930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY05_02935	COG2871	sodium ion transport
HPY05_02940	COG1477	protein flavinylation
HPY05_02960	COG3706	GGDEF domain
HPY05_02965	COG0733	neurotransmitter:sodium symporter activity
HPY05_02970	COG3385	transposase activity
HPY05_02980	COG0189	ligase activity
HPY05_02985	COG0189	ligase activity
HPY05_02985	COG4067	protein conserved in archaea
HPY05_02990	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY05_02995	COG2252	PERMEase
HPY05_03000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY05_03015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY05_03020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY05_03025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY05_03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY05_03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY05_03045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY05_03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY05_03055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY05_03060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY05_03070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY05_03075	COG0024	Methionine aminopeptidase
HPY05_03080	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY05_03085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY05_03090	COG0528	UMP kinase activity
HPY05_03095	COG0233	cytoplasmic translational termination
HPY05_03100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY05_03105	COG0575	Belongs to the CDS family
HPY05_03110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY05_03115	COG0750	zinc metalloprotease
HPY05_03125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY05_03130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY05_03135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY05_03140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY05_03145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY05_03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY05_03155	COG0587	DNA-directed DNA polymerase activity
HPY05_03160	COG0825	malonyl-CoA metabolic process
HPY05_03165	COG0037	tRNA processing
HPY05_03175	COG3479	Phenolic acid decarboxylase
HPY05_03180	COG0347	Belongs to the P(II) protein family
HPY05_03185	COG3021	interspecies interaction between organisms
HPY05_03190	COG0741	lytic transglycosylase activity
HPY05_03190	COG1388	LysM domain
HPY05_03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY05_03200	COG2226	methyltransferase
HPY05_03205	COG0328	RNA-DNA hybrid ribonuclease activity
HPY05_03220	COG1960	acyl-CoA dehydrogenase activity
HPY05_03225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY05_03230	COG0121	glutamine amidotransferase
HPY05_03235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY05_03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY05_03245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY05_03250	COG3706	GGDEF domain
HPY05_03255	COG1187	pseudouridine synthase activity
HPY05_03260	COG2840	Smr protein MutS2
HPY05_03295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY05_03310	COG4774	siderophore transport
HPY05_03310	COG1629	transport
HPY05_03315	COG2375	cellular response to nickel ion
HPY05_03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY05_03320	COG2226	methyltransferase
HPY05_03320	COG3433	isochorismatase activity
HPY05_03355	COG0835	chemotaxis
HPY05_03355	COG0784	Response regulator, receiver
HPY05_03360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY05_03365	COG1815	bacterial-type flagellum-dependent cell motility
HPY05_03380	COG1749	Flagellar hook protein flgE
HPY05_03385	COG4787	bacterial-type flagellum-dependent cell motility
HPY05_03395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY05_03400	COG1706	bacterial-type flagellum-dependent cell motility
HPY05_03405	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY05_03405	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY05_03420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY05_03425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY05_03510	COG0012	GTP binding
HPY05_03515	COG0193	aminoacyl-tRNA hydrolase activity
HPY05_03520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY05_03525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY05_03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY05_03535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY05_03540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY05_03545	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY05_03555	COG2912	Transglutaminase-like superfamily
HPY05_03560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY05_03565	COG0737	Belongs to the 5'-nucleotidase family
HPY05_03570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY05_03575	COG2233	PERMEase
HPY05_03595	COG1393	Belongs to the ArsC family
HPY05_03600	COG4783	chaperone-mediated protein folding
HPY05_03620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY05_03635	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY05_03645	COG1876	peptidase activity
HPY05_03655	COG1393	Belongs to the ArsC family
HPY05_03675	COG2837	iron assimilation
HPY05_03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY05_03685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY05_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY05_03695	COG1334	flagellar protein FlaG
HPY05_03700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY05_03710	COG1516	flagellar protein fliS
HPY05_03720	COG4191	Histidine kinase
HPY05_03730	COG1677	Flagellar hook-basal body complex protein FliE
HPY05_03740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY05_03745	COG1317	bacterial-type flagellum organization
HPY05_03770	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY05_03795	COG1987	bacterial-type flagellum assembly
HPY05_03800	COG1684	flagellar biosynthetic protein fliR
HPY05_03810	COG2840	Smr protein MutS2
HPY05_03815	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY05_03820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY05_03825	COG2860	membrane
HPY05_03830	COG3101	peptidyl-lysine hydroxylation
HPY05_03840	COG0431	NADPH-dependent FMN reductase
HPY05_03845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY05_03845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY05_03850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY05_03855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY05_03860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY05_03865	COG0735	belongs to the Fur family
HPY05_03875	COG0583	DNA-binding transcription factor activity
HPY05_03885	COG1346	cytolysis
HPY05_03900	COG0596	Alpha beta hydrolase
HPY05_03905	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY05_03910	COG0033	Phosphoglucomutase
HPY05_03920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY05_03925	COG0372	Belongs to the citrate synthase family
HPY05_03930	COG2009	succinate dehydrogenase
HPY05_03935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY05_03940	COG1053	succinate dehydrogenase
HPY05_03950	COG0567	Dehydrogenase, E1 component
HPY05_03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY05_03960	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY05_03970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY05_03975	COG1121	(ABC) transporter
HPY05_03980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY05_03985	COG4977	sequence-specific DNA binding
HPY05_03990	COG1918	ferrous iron import across plasma membrane
HPY05_04010	COG0018	arginyl-trna synthetase
HPY05_04020	COG1025	Belongs to the peptidase M16 family
HPY05_04025	COG2062	phosphohistidine phosphatase, SixA
HPY05_04055	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY05_04060	COG0784	Response regulator, receiver
HPY05_04060	COG0643	Histidine kinase
HPY05_04060	COG2198	Histidine kinase
HPY05_04065	COG2201	protein-glutamate methylesterase activity
HPY05_04070	COG1192	Involved in chromosome partitioning
HPY05_04080	COG0835	chemotaxis
HPY05_04090	COG4133	protoheme IX ABC transporter activity
HPY05_04095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY05_04100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY05_04110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY05_04115	COG1138	Cytochrome C-type biogenesis protein
HPY05_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY05_04135	COG2853	Lipoprotein
HPY05_04155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY05_04160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY05_04165	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY05_04180	COG3083	sulfuric ester hydrolase activity
HPY05_04185	COG3082	Protein of unknown function (DUF1414)
HPY05_04190	COG3081	Nucleoid-associated protein
HPY05_04200	COG1757	Na H antiporter
HPY05_04205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY05_04210	COG2095	MarC family integral membrane protein
HPY05_04215	COG1454	alcohol dehydrogenase
HPY05_04215	COG1012	belongs to the aldehyde dehydrogenase family
HPY05_04225	COG0659	secondary active sulfate transmembrane transporter activity
HPY05_04230	COG1530	ribonuclease E activity
HPY05_04235	COG0564	pseudouridine synthase activity
HPY05_04240	COG0424	maF-like protein
HPY05_04245	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY05_04250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY05_04255	COG0416	fatty acid biosynthetic process
HPY05_04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY05_04270	COG1028	Short-chain dehydrogenase reductase Sdr
HPY05_04275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY05_04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY05_04285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY05_04290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY05_04295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY05_04305	COG0084	hydrolase, TatD family'
HPY05_04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY05_04310	COG1263	PTS System
HPY05_04320	COG0733	neurotransmitter:sodium symporter activity
HPY05_04335	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY05_04345	COG1940	carbohydrate kinase activity
HPY05_04350	COG0784	Response regulator, receiver
HPY05_04350	COG0835	chemotaxis
HPY05_04365	COG2226	methyltransferase
HPY05_04375	COG0676	glucose-6-phosphate 1-epimerase activity
HPY05_04380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY05_04385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY05_04395	COG3139	Protein of unknown function (DUF1315)
HPY05_04400	COG0252	asparaginase activity
HPY05_04405	COG0616	signal peptide processing
HPY05_04410	COG1902	pentaerythritol trinitrate reductase activity
HPY05_04410	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY05_04415	COG0788	formyltetrahydrofolate deformylase activity
HPY05_04425	COG1199	ATP-dependent helicase activity
HPY05_04430	COG1214	PFAM Peptidase M22, glycoprotease
HPY05_04445	COG0596	Alpha beta hydrolase
HPY05_04450	COG0318	PFAM AMP-dependent synthetase and ligase
HPY05_04455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY05_04475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY05_04480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY05_04485	COG0436	Aminotransferase
HPY05_04490	COG1169	isochorismate synthase
HPY05_04495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY05_04500	COG0596	Alpha beta hydrolase
HPY05_04520	COG3135	benzoate transporter
HPY05_04545	COG3015	lipoprotein NlpE involved in copper resistance
HPY05_04550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY05_04555	COG2894	cell division
HPY05_04560	COG0850	regulation of cytokinetic process
HPY05_04565	COG3100	YcgL domain-containing protein
HPY05_04570	COG2951	lytic endotransglycosylase activity
HPY05_04580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY05_04585	COG3005	denitrification pathway
HPY05_04590	COG0243	molybdopterin cofactor binding
HPY05_04605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY05_04620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY05_04655	COG4589	Belongs to the CDS family
HPY05_04665	COG5001	Diguanylate cyclase
HPY05_04665	COG3300	MHYT domain
HPY05_04675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY05_04680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY05_04685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY05_04690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY05_04700	COG4191	Histidine kinase
HPY05_04710	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY05_04720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY05_04725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY05_04730	COG0776	regulation of translation
HPY05_04735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY05_04740	COG1555	photosystem II stabilization
HPY05_04745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY05_04750	COG0539	negative regulation of cytoplasmic translation
HPY05_04755	COG0776	regulation of translation
HPY05_04760	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY05_04765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY05_04785	COG0583	DNA-binding transcription factor activity
HPY05_04795	COG0686	Belongs to the AlaDH PNT family
HPY05_04805	COG1674	ftsk spoiiie
HPY05_04810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY05_04815	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY05_04820	COG2186	Transcriptional regulator
HPY05_04835	COG0537	adenosine 5'-monophosphoramidase activity
HPY05_04860	COG3150	esterase
HPY05_04865	COG1252	NADH dehydrogenase
HPY05_04890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY05_04905	COG1136	(ABC) transporter
HPY05_04910	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY05_04920	COG2333	competence protein COMEC
HPY05_04920	COG0658	competence protein
HPY05_04925	COG1132	(ABC) transporter
HPY05_04930	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY05_04935	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY05_04940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY05_04945	COG2719	SpoVR family
HPY05_04950	COG2718	Belongs to the UPF0229 family
HPY05_04955	COG2766	serine protein kinase
HPY05_04960	COG3385	transposase activity
HPY05_04965	COG3013	Belongs to the UPF0304 family
HPY05_04975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY05_04980	COG0840	transmembrane signaling receptor activity
HPY05_04990	COG1882	Formate acetyltransferase
HPY05_05015	COG4160	amino acid transport
HPY05_05020	COG0708	Exodeoxyribonuclease III
HPY05_05030	COG3923	Primosomal replication protein n
HPY05_05035	COG0730	response to heat
HPY05_05040	COG1199	ATP-dependent helicase activity
HPY05_05050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY05_05055	COG3012	SEC-C Motif Domain Protein
HPY05_05060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY05_05065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY05_05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY05_05075	COG0215	cysteine-tRNA ligase activity
HPY05_05080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY05_05085	COG0632	four-way junction helicase activity
HPY05_05095	COG1271	oxidase subunit
HPY05_05100	COG1294	oxidase, subunit
HPY05_05105	COG4890	Cyd operon protein YbgT
HPY05_05110	COG3790	cyd operon protein YbgE
HPY05_05115	COG0824	Thioesterase
HPY05_05120	COG0811	peptide transport
HPY05_05135	COG0823	Involved in the tonB-independent uptake of proteins
HPY05_05140	COG2885	chlorophyll binding
HPY05_05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY05_05160	COG0784	Response regulator, receiver
HPY05_05160	COG5002	protein histidine kinase activity
HPY05_05170	COG1482	cell wall glycoprotein biosynthetic process
HPY05_05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY05_05175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY05_05175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY05_05180	COG2207	Transcriptional regulator
HPY05_05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY05_05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY05_05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY05_05210	COG1012	belongs to the aldehyde dehydrogenase family
HPY05_05215	COG3284	Transcriptional regulator
HPY05_05220	COG4628	conserved protein (DUF2132)
HPY05_05230	COG0415	Belongs to the DNA photolyase family
HPY05_05315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY05_05325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY05_05365	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HPY05_05410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY05_05425	COG0681	Belongs to the peptidase S26 family
HPY05_05470	COG3064	Membrane
HPY05_05500	COG2351	hydroxyisourate hydrolase activity
HPY05_05515	COG5492	domain, Protein
HPY05_05515	COG4932	domain protein
HPY05_05540	COG4796	Type ii and iii secretion system protein
HPY05_05560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY05_05565	COG1459	type II secretion system
HPY05_05585	COG2207	Transcriptional regulator
HPY05_05630	COG3710	Transcriptional regulator
HPY05_05635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY05_05680	COG0629	single-stranded DNA binding
HPY05_05700	COG0714	Associated with various cellular activities
HPY05_05725	COG2003	Belongs to the UPF0758 family
HPY05_05765	COG3311	Transcriptional regulator
HPY05_05770	COG0582	viral genome integration into host DNA
HPY05_05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY05_05795	COG3008	intermembrane lipid transfer
HPY05_05795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY05_05800	COG2995	paraquat-inducible protein a
HPY05_05805	COG0668	transmembrane transport
HPY05_05825	COG1309	transcriptional regulator
HPY05_05830	COG1012	belongs to the aldehyde dehydrogenase family
HPY05_05855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY05_05860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY05_05865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY05_05870	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY05_05885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY05_05890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY05_05895	COG0297	glycogen (starch) synthase activity
HPY05_05915	COG3070	regulator of competence-specific genes
HPY05_05920	COG1609	Transcriptional regulator
HPY05_05930	COG0745	RESPONSE REGULATOR receiver
HPY05_05935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY05_05940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY05_05945	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY05_05950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY05_05965	COG1280	lysine exporter protein (LysE YggA)
HPY05_05970	COG1032	radical SAM domain protein
HPY05_05975	COG5001	Diguanylate cyclase
HPY05_05980	COG0612	Peptidase, M16
HPY05_05995	COG0583	DNA-binding transcription factor activity
HPY05_06000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY05_06010	COG2350	Protein conserved in bacteria
HPY05_06015	COG1607	acyl-coa hydrolase
HPY05_06030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY05_06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY05_06045	COG2116	formate transmembrane transporter activity
HPY05_06050	COG4459	periplasmic nitrate reductase
HPY05_06055	COG3005	denitrification pathway
HPY05_06060	COG0243	molybdopterin cofactor binding
HPY05_06080	COG1227	inorganic diphosphatase activity
HPY05_06100	COG4172	Belongs to the ABC transporter superfamily
HPY05_06115	COG4168	peptide transport system, permease
HPY05_06125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY05_06130	COG1842	Phage shock protein A
HPY05_06145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY05_06160	COG2818	Glycosylase
HPY05_06165	COG0626	cystathionine gamma-synthase activity
HPY05_06175	COG0733	neurotransmitter:sodium symporter activity
HPY05_06180	COG0564	pseudouridine synthase activity
HPY05_06185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY05_06190	COG4136	ATPase activity
HPY05_06195	COG4135	transport system, permease component
HPY05_06200	COG4134	Bacterial extracellular solute-binding protein
HPY05_06210	COG3313	Fe-S protein
HPY05_06220	COG0814	amino acid
HPY05_06230	COG2239	Acts as a magnesium transporter
HPY05_06235	COG2205	protein histidine kinase activity
HPY05_06235	COG0784	Response regulator, receiver
HPY05_06250	COG4934	collagen metabolic process
HPY05_06285	COG0840	transmembrane signaling receptor activity
HPY05_06295	COG4251	negative regulation of phosphorylation
HPY05_06295	COG2203	Gaf domain
HPY05_06295	COG3706	GGDEF domain
HPY05_06295	COG5001	Diguanylate cyclase
HPY05_06300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY05_06305	COG5002	protein histidine kinase activity
HPY05_06325	COG1187	pseudouridine synthase activity
HPY05_06330	COG2814	Major facilitator Superfamily
HPY05_06340	COG0702	epimerase
HPY05_06345	COG0534	Mate efflux family protein
HPY05_06350	COG4181	ATPase activity
HPY05_06365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY05_06375	COG1748	Saccharopine dehydrogenase
HPY05_06390	COG1538	Outer membrane efflux protein
HPY05_06460	COG0583	DNA-binding transcription factor activity
HPY05_06470	COG1451	nucleotide metabolic process
HPY05_06485	COG3063	Type IV pilus biogenesis stability protein PilW
HPY05_06490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY05_06510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY05_06525	COG3290	protein histidine kinase activity
HPY05_06530	COG4565	transcriptional regulatory protein
HPY05_06540	COG0835	chemotaxis
HPY05_06540	COG0784	Response regulator, receiver
HPY05_06590	COG1085	galactose-1-phosphate uridylyltransferase
HPY05_06595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY05_06600	COG2017	converts alpha-aldose to the beta-anomer
HPY05_06615	COG3527	Alpha-acetolactate decarboxylase
HPY05_06625	COG3064	Membrane
HPY05_06635	COG0753	catalase activity
HPY05_06655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY05_06705	COG1271	oxidase subunit
HPY05_06710	COG1294	oxidase, subunit
HPY05_06715	COG1136	(ABC) transporter
HPY05_06715	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY05_06720	COG0577	efflux transmembrane transporter activity
HPY05_06720	COG1136	(ABC) transporter
HPY05_06725	COG0577	efflux transmembrane transporter activity
HPY05_06725	COG1136	(ABC) transporter
HPY05_06775	COG2816	NAD+ diphosphatase activity
HPY05_06780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY05_06795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY05_06805	COG2723	6-phospho-beta-galactosidase activity
HPY05_06810	COG1609	Transcriptional regulator
HPY05_06815	COG0251	oxidation-reduction process
HPY05_06820	COG2731	YhcH YjgK YiaL family protein
HPY05_06825	COG0584	glycerophosphoryl diester phosphodiesterase
HPY05_06830	COG1349	DNA-binding transcription factor activity
HPY05_06835	COG3842	ATPase activity
HPY05_06840	COG0395	ABC-type sugar transport system, permease component
HPY05_06845	COG1175	transmembrane transport
HPY05_06860	COG0811	peptide transport
HPY05_06865	COG0811	peptide transport
HPY05_06870	COG0848	biopolymer transport protein
HPY05_06875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY05_06885	COG1793	dna ligase
HPY05_06895	COG0534	Mate efflux family protein
HPY05_06905	COG3001	Fructosamine kinase
HPY05_06915	COG0791	NLP P60 protein
HPY05_06920	COG0840	transmembrane signaling receptor activity
HPY05_06935	COG1940	carbohydrate kinase activity
HPY05_06955	COG0746	molybdenum cofactor guanylyltransferase activity
HPY05_06960	COG3842	ATPase activity
HPY05_06965	COG4662	Binding-protein-dependent transport system inner membrane component
HPY05_06975	COG2204	response regulator
HPY05_06980	COG3852	Histidine kinase
HPY05_06985	COG0488	(ABC) transporter
HPY05_06990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY05_07020	COG3383	formate dehydrogenase (NAD+) activity
HPY05_07020	COG0243	molybdopterin cofactor binding
HPY05_07025	COG0437	4 iron, 4 sulfur cluster binding
HPY05_07040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY05_07045	COG1666	GTP binding
HPY05_07050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY05_07065	COG2996	Protein conserved in bacteria
HPY05_07075	COG3008	intermembrane lipid transfer
HPY05_07080	COG2995	paraquat-inducible protein a
HPY05_07085	COG1132	(ABC) transporter
HPY05_07090	COG1956	GAF domain-containing protein
HPY05_07095	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY05_07110	COG0308	aminopeptidase N
HPY05_07125	COG0167	dihydroorotate dehydrogenase activity
HPY05_07135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY05_07135	COG0116	Belongs to the methyltransferase superfamily
HPY05_07160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY05_07165	COG1067	ATP-dependent peptidase activity
HPY05_07170	COG3120	sequence-specific DNA binding
HPY05_07270	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY05_07270	COG1073	alpha beta
HPY05_07270	COG3064	Membrane
HPY05_07275	COG2994	toxin metabolic process
HPY05_07300	COG0784	Response regulator, receiver
HPY05_07300	COG2205	protein histidine kinase activity
HPY05_07330	COG2010	Cytochrome c
HPY05_07340	COG2217	Heavy metal translocating P-type atpase
HPY05_07355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY05_07360	COG0589	response to stress
HPY05_07365	COG0037	tRNA processing
HPY05_07385	COG3842	ATPase activity
HPY05_07395	COG1177	transmembrane transport
HPY05_07405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY05_07420	COG1115	amino acid carrier protein
HPY05_07425	COG1280	lysine exporter protein (LysE YggA)
HPY05_07455	COG3501	Rhs element vgr protein
HPY05_07465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY05_07485	COG0513	Belongs to the DEAD box helicase family
HPY05_07490	COG2076	Multidrug Resistance protein
HPY05_07495	COG0415	Belongs to the DNA photolyase family
HPY05_07500	COG0477	Major facilitator Superfamily
HPY05_07505	COG0583	DNA-binding transcription factor activity
HPY05_07515	COG0402	S-adenosylhomocysteine deaminase activity
HPY05_07520	COG0095	Lipoate-protein ligase
HPY05_07525	COG0443	Heat shock 70 kDa protein
HPY05_07535	COG1643	Atp-dependent helicase
HPY05_07565	COG0443	Heat shock 70 kDa protein
HPY05_07570	COG0443	Heat shock 70 kDa protein
HPY05_07575	COG3706	GGDEF domain
HPY05_07605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY05_07610	COG0602	queuosine metabolic process
HPY05_07615	COG0561	phosphatase activity
HPY05_07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY05_07630	COG4597	amino acid ABC transporter
HPY05_07635	COG0765	amino acid transport
HPY05_07640	COG1126	abc transporter atp-binding protein
HPY05_07645	COG0670	Belongs to the BI1 family
HPY05_07650	COG2920	part of a sulfur-relay system
HPY05_07655	COG1254	Belongs to the acylphosphatase family
HPY05_07660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY05_07665	COG3706	GGDEF domain
HPY05_07675	COG3850	Histidine kinase
HPY05_07675	COG3437	response regulator, receiver
HPY05_07675	COG2205	protein histidine kinase activity
HPY05_07675	COG4999	Histidine kinase
HPY05_07680	COG3437	response regulator, receiver
HPY05_07685	COG0625	glutathione transferase activity
HPY05_07695	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY05_07705	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY05_07720	COG3385	transposase activity
HPY05_07740	COG0372	Belongs to the citrate synthase family
HPY05_07745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY05_07770	COG0583	DNA-binding transcription factor activity
HPY05_07775	COG4771	TonB-dependent receptor
HPY05_07800	COG1566	PFAM secretion protein HlyD family protein
HPY05_07820	COG1129	ABC transporter
HPY05_07845	COG0745	RESPONSE REGULATOR receiver
HPY05_07850	COG5002	protein histidine kinase activity
HPY05_07855	COG3713	MltA-interacting MipA family protein
HPY05_07860	COG2990	Protein conserved in bacteria
HPY05_07870	COG4191	Histidine kinase
HPY05_07870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY05_07875	COG0471	metal ion transport
HPY05_07885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY05_07900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY05_07910	COG3768	UPF0283 membrane protein
HPY05_07915	COG3106	COG3106 Predicted ATPase
HPY05_07930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY05_07935	COG0494	nUDIX hydrolase
HPY05_07940	COG0814	amino acid
HPY05_07945	COG1760	l-serine dehydratase
HPY05_07950	COG3385	transposase activity
HPY05_07955	COG0720	synthase
HPY05_07965	COG0840	transmembrane signaling receptor activity
HPY05_07970	COG0017	Asparaginyl-tRNA synthetase
HPY05_07975	COG0351	phosphomethylpyrimidine kinase
HPY05_07980	COG3437	response regulator, receiver
HPY05_07980	COG2770	Histidine kinase
HPY05_07985	COG1448	Aminotransferase
HPY05_08000	COG0840	transmembrane signaling receptor activity
HPY05_08005	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY05_08010	COG2943	transferase activity, transferring hexosyl groups
HPY05_08015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY05_08020	COG1846	Transcriptional regulator
HPY05_08045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY05_08060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY05_08065	COG3108	Peptidase M15
HPY05_08095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY05_08105	COG2814	Major facilitator Superfamily
HPY05_08125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY05_08130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY05_08135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY05_08180	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY05_08185	COG4139	cobalamin transport
HPY05_08190	COG2988	succinylglutamate desuccinylase activity
HPY05_08205	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY05_08210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY05_08215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY05_08225	COG2925	Exonuclease
HPY05_08230	COG1380	Effector of murein hydrolase LrgA
HPY05_08235	COG1346	cytolysis
HPY05_08270	COG0776	regulation of translation
HPY05_08275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY05_08275	COG0072	phenylalanine-tRNA ligase activity
HPY05_08280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY05_08320	COG0322	excinuclease ABC activity
HPY05_08325	COG2197	response regulator
HPY05_08330	COG0417	DNA replication proofreading
HPY05_08335	COG5001	Diguanylate cyclase
HPY05_08345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY05_08350	COG3099	Belongs to the UPF0263 family
HPY05_08365	COG1228	amidohydrolase
HPY05_08370	COG0010	Belongs to the arginase family
HPY05_08375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY05_08380	COG2986	histidine ammonia-lyase
HPY05_08400	COG0247	lactate metabolic process
HPY05_08400	COG0277	FAD linked oxidase domain protein
HPY05_08415	COG2885	chlorophyll binding
HPY05_08435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY05_08445	COG0281	malic enzyme
HPY05_08455	COG2949	membrane
HPY05_08460	COG3706	GGDEF domain
HPY05_08465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY05_08475	COG0492	ferredoxin-NADP+ reductase activity
HPY05_08480	COG4988	ABC transporter
HPY05_08485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY05_08490	COG1187	pseudouridine synthase activity
HPY05_08495	COG0009	L-threonylcarbamoyladenylate synthase
HPY05_08500	COG0613	PHP domain protein
HPY05_08510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY05_08515	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY05_08520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY05_08525	COG0135	phosphoribosylanthranilate isomerase activity
HPY05_08525	COG0134	indole-3-glycerol-phosphate synthase activity
HPY05_08530	COG0133	tryptophan synthase activity
HPY05_08535	COG0159	tryptophan synthase activity
HPY05_08545	COG1435	thymidine kinase activity
HPY05_08550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY05_08555	COG1801	Protein of unknown function DUF72
HPY05_08560	COG4106	trans-aconitate 2-methyltransferase activity
HPY05_08565	COG0500	methyltransferase
HPY05_08570	COG4067	protein conserved in archaea
HPY05_08570	COG0189	ligase activity
HPY05_08585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY05_08595	COG3852	Histidine kinase
HPY05_08610	COG3070	regulator of competence-specific genes
HPY05_08620	COG2431	L-lysine efflux transmembrane transporter activity
HPY05_08630	COG0076	glutamate decarboxylase activity
HPY05_08635	COG1737	Transcriptional regulator
HPY05_08640	COG1454	alcohol dehydrogenase
HPY05_08640	COG1012	belongs to the aldehyde dehydrogenase family
HPY05_08645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY05_08650	COG2985	domain, Protein
HPY05_08650	COG3273	potassium ion transport
HPY05_08655	COG0542	response to heat
HPY05_08660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY05_08665	COG1278	Cold shock
HPY05_08675	COG1187	pseudouridine synthase activity
HPY05_08680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY05_08680	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY05_08685	COG0107	imidazoleglycerol-phosphate synthase activity
HPY05_08690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY05_08695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY05_08700	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY05_08700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY05_08705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY05_08710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY05_08715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY05_08720	COG1757	Na H antiporter
HPY05_08725	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY05_08730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY05_08735	COG0482	sulfurtransferase activity
HPY05_08740	COG2915	High frequency lysogenization protein hflD homolog
HPY05_08745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY05_08755	COG2268	Band 7 protein
HPY05_08765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY05_08780	COG0300	oxidoreductase activity
HPY05_08790	COG0501	Belongs to the peptidase M48B family
HPY05_08800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY05_08805	COG2226	methyltransferase
HPY05_08810	COG0156	8-amino-7-oxononanoate synthase activity
HPY05_08815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY05_08820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY05_08825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY05_08830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY05_08835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY05_08840	COG0653	protein targeting
HPY05_08845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY05_08850	COG3706	GGDEF domain
HPY05_08860	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY05_08870	COG4628	conserved protein (DUF2132)
HPY05_08875	COG3092	negative regulation of chromosome organization
HPY05_08880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY05_08885	COG0280	phosphate acetyltransferase
HPY05_08885	COG0857	belongs to the CobB CobQ family
HPY05_08890	COG0435	Glutathione S-transferase
HPY05_08895	COG4608	Belongs to the ABC transporter superfamily
HPY05_08900	COG0444	Belongs to the ABC transporter superfamily
HPY05_08905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY05_08910	COG0601	transmembrane transport
HPY05_08930	COG2204	response regulator
HPY05_08935	COG5001	Diguanylate cyclase
HPY05_08935	COG3300	MHYT domain
HPY05_08940	COG4191	Histidine kinase
HPY05_08945	COG5002	protein histidine kinase activity
HPY05_08955	COG2201	protein-glutamate methylesterase activity
HPY05_08970	COG0009	L-threonylcarbamoyladenylate synthase
HPY05_08995	COG1881	PFAM PEBP family protein
HPY05_09020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY05_09025	COG0640	Transcriptional regulator
HPY05_09035	COG3706	GGDEF domain
HPY05_09055	COG1946	Acyl-CoA thioesterase
HPY05_09060	COG1522	sequence-specific DNA binding
HPY05_09070	COG0616	signal peptide processing
HPY05_09075	COG1028	Short-chain dehydrogenase reductase Sdr
HPY05_09085	COG2983	Belongs to the UPF0260 family
HPY05_09100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY05_09105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY05_09110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY05_09115	COG2832	Protein of unknown function (DUF454)
HPY05_09120	COG0745	RESPONSE REGULATOR receiver
HPY05_09125	COG0583	DNA-binding transcription factor activity
HPY05_09130	COG0778	Nitroreductase
HPY05_09135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY05_09135	COG1024	Enoyl-CoA hydratase
HPY05_09140	COG0183	Belongs to the thiolase family
HPY05_09155	COG2067	long-chain fatty acid transport protein
HPY05_09160	COG2067	long-chain fatty acid transport protein
HPY05_09165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY05_09170	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY05_09175	COG2982	Protein involved in outer membrane biogenesis
HPY05_09180	COG0572	uridine kinase
HPY05_09185	COG0489	protein tyrosine kinase activity
HPY05_09190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY05_09190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY05_09200	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY05_09210	COG0517	IMP dehydrogenase activity
HPY05_09210	COG0617	tRNA 3'-terminal CCA addition
HPY05_09210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY05_09215	COG2199	diguanylate cyclase activity
HPY05_09220	COG0314	molybdopterin synthase activity
HPY05_09225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY05_09230	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY05_09235	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY05_09240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY05_09245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY05_09250	COG2198	Histidine kinase
HPY05_09255	COG2204	response regulator
HPY05_09260	COG0556	nucleotide-excision repair
HPY05_09270	COG4657	Part of a membrane complex involved in electron transport
HPY05_09275	COG2878	Part of a membrane complex involved in electron transport
HPY05_09280	COG4656	Part of a membrane complex involved in electron transport
HPY05_09295	COG4660	Part of a membrane complex involved in electron transport
HPY05_09300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY05_09305	COG0346	lactoylglutathione lyase activity
HPY05_09320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY05_09325	COG2056	Na+-H+ antiporter family
HPY05_09330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY05_09335	COG1286	toxin biosynthetic process
HPY05_09340	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY05_09345	COG0285	dihydrofolate synthase activity
HPY05_09350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY05_09355	COG0101	tRNA pseudouridine synthase activity
HPY05_09370	COG1263	PTS System
HPY05_09370	COG2190	(PTS) system
HPY05_09370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY05_09375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY05_09380	COG1940	carbohydrate kinase activity
HPY05_09380	COG1846	Transcriptional regulator
HPY05_09385	COG4651	solute:proton antiporter activity
HPY05_09385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY05_09390	COG0367	asparagine synthase
HPY05_09405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY05_09410	COG0563	adenylate kinase activity
HPY05_09415	COG0326	Molecular chaperone. Has ATPase activity
HPY05_09420	COG3710	Transcriptional regulator
HPY05_09435	COG0622	Phosphoesterase
HPY05_09440	COG1090	epimerase
HPY05_09445	COG0300	oxidoreductase activity
HPY05_09450	COG3118	belongs to the thioredoxin family
HPY05_09455	COG0330	HflC and HflK could
HPY05_09460	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY05_09465	COG0789	Transcriptional regulator
HPY05_09480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY05_09490	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY05_09495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY05_09500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY05_09510	COG2190	(PTS) system
HPY05_09515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY05_09520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY05_09525	COG1702	phosphate starvation-inducible protein PhoH
HPY05_09530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY05_09535	COG4535	Mg2 and Co2 transporter CorC
HPY05_09540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY05_09545	COG2888	peptidyl-tyrosine sulfation
HPY05_09550	COG0495	leucyl-tRNA aminoacylation
HPY05_09555	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY05_09560	COG1466	dna polymerase III delta subunit
HPY05_09565	COG0799	negative regulation of ribosome biogenesis
HPY05_09570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY05_09575	COG0768	penicillin binding
HPY05_09580	COG0772	Belongs to the SEDS family
HPY05_09585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY05_09590	COG1686	Belongs to the peptidase S11 family
HPY05_09595	COG2921	Belongs to the UPF0250 family
HPY05_09600	COG0321	lipoyl(octanoyl) transferase activity
HPY05_09605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY05_09615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY05_09640	COG1596	polysaccharide export
HPY05_09650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY05_09680	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY05_09690	COG0438	transferase activity, transferring glycosyl groups
HPY05_09700	COG1045	serine acetyltransferase
HPY05_09720	COG0110	maltose O-acetyltransferase activity
HPY05_09725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY05_09730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY05_09735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY05_09740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY05_09775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY05_09775	COG1263	PTS System
HPY05_09780	COG1609	Transcriptional regulator
HPY05_09785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY05_09790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY05_09795	COG2011	ABC-type metal ion transport system permease component
HPY05_09800	COG1464	Belongs to the NlpA lipoprotein family
HPY05_09805	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY05_09815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY05_09815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY05_09825	COG3706	GGDEF domain
HPY05_09830	COG1611	Belongs to the LOG family
HPY05_09835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY05_09840	COG2363	Small membrane protein
HPY05_09845	COG0583	DNA-binding transcription factor activity
HPY05_09850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY05_09850	COG0301	tRNA thio-modification
HPY05_09860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY05_09865	COG1722	exodeoxyribonuclease VII activity
HPY05_09870	COG0142	geranyltranstransferase activity
HPY05_09875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY05_09880	COG0564	pseudouridine synthase activity
HPY05_09885	COG3098	single-species biofilm formation
HPY05_09900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY05_09910	COG1671	Belongs to the UPF0178 family
HPY05_09915	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY05_09920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY05_09925	COG0254	rRNA binding
HPY05_09930	COG1720	tRNA m6t6A37 methyltransferase activity
HPY05_09935	COG0442	prolyl-tRNA aminoacylation
HPY05_09955	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY05_09955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY05_09965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY05_09975	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY05_10005	COG0484	heat shock protein binding
HPY05_10010	COG0443	Heat shock 70 kDa protein
HPY05_10015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY05_10020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY05_10025	COG0497	DNA recombination
HPY05_10030	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY05_10035	COG2914	Belongs to the UPF0125 (RnfH) family
HPY05_10040	COG2867	negative regulation of translational initiation
HPY05_10045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY05_10075	COG1104	cysteine desulfurase activity
HPY05_10140	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY05_10145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY05_10150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY05_10170	COG3051	citrate lyase alpha subunit
HPY05_10175	COG2301	Belongs to the HpcH HpaI aldolase family
HPY05_10185	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY05_10195	COG3630	sodium ion export across plasma membrane
HPY05_10200	COG5016	pyruvate
HPY05_10200	COG0511	ligase activity, forming carbon-carbon bonds
HPY05_10205	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY05_10215	COG4565	transcriptional regulatory protein
HPY05_10240	COG1115	amino acid carrier protein
HPY05_10245	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY05_10250	COG0583	DNA-binding transcription factor activity
HPY05_10260	COG1120	ATPase activity
HPY05_10265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY05_10270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY05_10275	COG4592	Periplasmic binding protein
HPY05_10285	COG1028	Short-chain dehydrogenase reductase Sdr
HPY05_10290	COG1169	isochorismate synthase
HPY05_10295	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY05_10300	COG1535	isochorismatase
HPY05_10300	COG3433	isochorismatase activity
HPY05_10305	COG1584	GPR1 FUN34 yaaH family protein
HPY05_10315	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY05_10325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY05_10325	COG0519	Catalyzes the synthesis of GMP from XMP
HPY05_10330	COG0516	GMP reductase activity
HPY05_10330	COG0517	IMP dehydrogenase activity
HPY05_10335	COG1570	exodeoxyribonuclease VII activity
HPY05_10350	COG1160	GTP binding
HPY05_10355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY05_10360	COG2976	Protein conserved in bacteria
HPY05_10365	COG0124	histidyl-tRNA synthetase
HPY05_10370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY05_10380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPY05_10385	COG0105	UTP biosynthetic process
HPY05_10390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY05_10395	COG2975	iron-sulfur cluster assembly
HPY05_10400	COG0633	Ferredoxin
HPY05_10420	COG0822	iron-sulfur transferase activity
HPY05_10430	COG1959	2 iron, 2 sulfur cluster binding
HPY05_10440	COG0483	inositol monophosphate 1-phosphatase activity
HPY05_10445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY05_10450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY05_10455	COG1862	Preprotein translocase
HPY05_10465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY05_10470	COG0517	IMP dehydrogenase activity
HPY05_10480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY05_10485	COG0583	DNA-binding transcription factor activity
HPY05_10490	COG0450	alkyl hydroperoxide reductase
HPY05_10495	COG3142	Participates in the control of copper homeostasis
HPY05_10510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY05_10515	COG0581	inorganic phosphate transmembrane transporter activity
HPY05_10525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY05_10530	COG0248	Ppx GppA phosphatase
HPY05_10540	COG5002	protein histidine kinase activity
HPY05_10545	COG0745	RESPONSE REGULATOR receiver
HPY05_10560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY05_10605	COG0542	response to heat
HPY05_10615	COG0564	pseudouridine synthase activity
HPY05_10620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY05_10625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY05_10630	COG0077	Prephenate dehydratase
HPY05_10630	COG1605	Chorismate mutase
HPY05_10635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY05_10640	COG5001	Diguanylate cyclase
HPY05_10650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY05_10660	COG0488	(ABC) transporter
HPY05_10670	COG0287	Prephenate dehydrogenase
HPY05_10670	COG1605	Chorismate mutase
HPY05_10675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY05_10680	COG3275	phosphorelay sensor kinase activity
HPY05_10685	COG3279	Response regulator of the LytR AlgR family
HPY05_10695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY05_10700	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY05_10715	COG1966	Carbon starvation protein
HPY05_10720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY05_10725	COG1047	Peptidyl-prolyl cis-trans
HPY05_10730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY05_10740	COG0196	riboflavin kinase activity
HPY05_10745	COG0728	peptidoglycan biosynthetic process
HPY05_10750	COG0268	Binds directly to 16S ribosomal RNA
HPY05_10755	COG0640	Transcriptional regulator
HPY05_10760	COG0583	DNA-binding transcription factor activity
HPY05_10765	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY05_10770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPY05_10775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY05_10780	COG0730	response to heat
HPY05_10785	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY05_10790	COG0494	nUDIX hydrolase
HPY05_10795	COG3066	DNA modification
HPY05_10800	COG0667	Aldo Keto reductase
HPY05_10810	COG2204	response regulator
HPY05_10815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY05_10835	COG0513	Belongs to the DEAD box helicase family
HPY05_10860	COG3153	acetyltransferase
HPY05_10865	COG3154	lipid carrier protein
HPY05_10875	COG0826	peptidase U32
HPY05_10880	COG0826	peptidase U32
HPY05_10905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY05_10915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY05_10920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY05_10925	COG0195	Participates in both transcription termination and antitermination
HPY05_10930	COG0779	Required for maturation of 30S ribosomal subunits
HPY05_10945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY05_10955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY05_10960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY05_10965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY05_10970	COG1534	Rna-binding protein
HPY05_10975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY05_10980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY05_10985	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY05_10990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY05_10995	COG0739	heme binding
HPY05_11010	COG0316	Belongs to the HesB IscA family
HPY05_11015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY05_11020	COG0628	permease
HPY05_11025	COG2813	Specifically methylates the guanine in position
HPY05_11030	COG0784	Response regulator, receiver
HPY05_11030	COG2205	protein histidine kinase activity
HPY05_11035	COG0747	negative chemotaxis
HPY05_11045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY05_11050	COG0444	Belongs to the ABC transporter superfamily
HPY05_11055	COG4608	Belongs to the ABC transporter superfamily
HPY05_11065	COG2971	BadF BadG BcrA BcrD
HPY05_11085	COG3842	ATPase activity
HPY05_11095	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY05_11100	COG0004	ammonium transporteR
HPY05_11105	COG0347	Belongs to the P(II) protein family
HPY05_11110	COG3112	Uncharacterised protein family (UPF0231)
HPY05_11115	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY05_11120	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY05_11125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY05_11130	COG1643	Atp-dependent helicase
HPY05_11140	COG1489	DNA binding
HPY05_11150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY05_11160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY05_11165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY05_11170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY05_11175	COG0842	Transport permease protein
HPY05_11180	COG1131	(ABC) transporter
HPY05_11185	COG0659	secondary active sulfate transmembrane transporter activity
HPY05_11190	COG0288	reversible hydration of carbon dioxide
HPY05_11205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY05_11210	COG3107	peptidoglycan biosynthetic process
HPY05_11215	COG0792	nuclease activity
HPY05_11220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY05_11225	COG2823	Periplasmic or secreted lipoprotein
HPY05_11230	COG2969	positive regulation of protein catabolic process
HPY05_11235	COG0625	glutathione transferase activity
HPY05_11240	COG2857	Cytochrome c1
HPY05_11250	COG0723	plastoquinol--plastocyanin reductase activity
HPY05_11255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY05_11260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY05_11265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY05_11275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY05_11280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY05_11285	COG0335	large ribosomal subunit rRNA binding
HPY05_11290	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY05_11295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY05_11300	COG0228	four-way junction DNA binding
HPY05_11305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY05_11310	COG4137	Cytochrome C assembly protein
HPY05_11315	COG4536	flavin adenine dinucleotide binding
HPY05_11320	COG1854	S-ribosylhomocysteine lyase activity
HPY05_11325	COG2918	glutathione biosynthetic process
HPY05_11330	COG0612	Peptidase, M16
HPY05_11335	COG1238	metal cluster binding
HPY05_11345	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY05_11350	COG0511	ligase activity, forming carbon-carbon bonds
HPY05_11350	COG5016	pyruvate
HPY05_11355	COG3630	sodium ion export across plasma membrane
HPY05_11400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY05_11405	COG0527	aspartate kinase activity
HPY05_11410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY05_11420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY05_11430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY05_11435	COG4208	sulfate ABC transporter
HPY05_11455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY05_11460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY05_11470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY05_11475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY05_11480	COG0585	pseudouridine synthase activity
HPY05_11485	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY05_11490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY05_11495	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY05_11500	COG1968	undecaprenyl-diphosphatase activity
HPY05_11505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY05_11510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY05_11515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY05_11525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY05_11530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY05_11535	COG1610	YqeY-like protein
HPY05_11540	COG0358	DNA primase activity
HPY05_11560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY05_11565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY05_11570	COG1349	DNA-binding transcription factor activity
HPY05_11590	COG1279	arginine transmembrane transporter activity
HPY05_11595	COG0668	transmembrane transport
HPY05_11600	COG0191	fructose-bisphosphate aldolase activity
HPY05_11610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY05_11615	COG4771	TonB-dependent receptor
HPY05_11620	COG0583	DNA-binding transcription factor activity
HPY05_11625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY05_11630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY05_11640	COG2356	endonuclease I
HPY05_11645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY05_11650	COG0189	ligase activity
HPY05_11655	COG1678	Uncharacterized ACR, COG1678
HPY05_11660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY05_11665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY05_11685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY05_11690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY05_11695	COG0762	integral membrane protein
HPY05_11700	COG1872	DUF167
HPY05_11710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY05_11715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY05_11720	COG2066	Belongs to the glutaminase family
HPY05_11725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY05_11730	COG1194	a g-specific adenine glycosylase
HPY05_11735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY05_11740	COG0741	lytic transglycosylase activity
HPY05_11795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY05_11800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY05_11805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY05_11810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY05_11815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY05_11820	COG2967	ApaG domain
HPY05_11825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY05_11835	COG3610	response to peptide
HPY05_11840	COG2966	Psort location CytoplasmicMembrane, score
HPY05_11845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY05_11850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY05_11855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY05_11860	COG0142	geranyltranstransferase activity
HPY05_11865	COG0531	amino acid
HPY05_11870	COG0039	L-malate dehydrogenase activity
HPY05_11875	COG1438	arginine binding
HPY05_11880	COG2358	TRAP transporter, solute receptor (TAXI family
HPY05_11890	COG0589	response to stress
HPY05_11910	COG2235	arginine
HPY05_11915	COG0312	modulator of DNA gyrase
HPY05_11920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY05_11925	COG3164	Protein of unknown function
HPY05_11930	COG1530	ribonuclease E activity
HPY05_11935	COG0424	maF-like protein
HPY05_11940	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY05_11945	COG1792	Involved in formation and maintenance of cell shape
HPY05_11950	COG1077	Cell shape determining protein MreB Mrl
HPY05_11995	COG1459	type II secretion system
HPY05_12000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY05_12010	COG3267	Type II secretory pathway component ExeA
HPY05_12010	COG3409	Peptidoglycan-binding domain 1 protein
HPY05_12035	COG2200	EAL domain
HPY05_12035	COG2199	diguanylate cyclase activity
HPY05_12040	COG0629	single-stranded DNA binding
HPY05_12055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY05_12065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY05_12070	COG0527	aspartate kinase activity
HPY05_12075	COG1410	methionine synthase
HPY05_12075	COG0646	methionine synthase
HPY05_12115	COG0175	sulfate reduction
HPY05_12125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY05_12150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY05_12155	COG0735	belongs to the Fur family
HPY05_12170	COG0166	Belongs to the GPI family
HPY05_12175	COG0432	Pfam Uncharacterised protein family UPF0047
HPY05_12180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY05_12195	COG0359	binds to the 23S rRNA
HPY05_12200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY05_12205	COG2965	DNA replication, synthesis of RNA primer
HPY05_12210	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY05_12220	COG2906	2 iron, 2 sulfur cluster binding
HPY05_12225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY05_12230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY05_12235	COG0049	tRNA binding
HPY05_12250	COG2923	Belongs to the DsrF TusC family
HPY05_12255	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY05_12260	COG2964	Protein conserved in bacteria
HPY05_12265	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY05_12275	COG2900	Belongs to the SlyX family
HPY05_12280	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY05_12285	COG0330	HflC and HflK could
HPY05_12290	COG0330	HflC and HflK could
HPY05_12295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY05_12300	COG1923	regulation of RNA biosynthetic process
HPY05_12305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY05_12310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY05_12320	COG0802	atpase or kinase
HPY05_12325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY05_12375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY05_12380	COG1162	GTPase activity
HPY05_12385	COG0688	phosphatidylethanolamine metabolic process
HPY05_12390	COG0471	metal ion transport
HPY05_12400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY05_12405	COG4942	peptidase
HPY05_12420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY05_12425	COG2816	NAD+ diphosphatase activity
HPY05_12430	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY05_12435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY05_12440	COG0085	RNA polymerase activity
HPY05_12445	COG0222	ribosome binding
HPY05_12450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY05_12460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY05_12465	COG0250	Participates in transcription elongation, termination and antitermination
HPY05_12470	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY05_12475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY05_12500	COG1072	(Pantothenic acid kinase))
HPY05_12510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY05_12520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY05_12600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY05_12615	COG3118	belongs to the thioredoxin family
HPY05_12620	COG0513	Belongs to the DEAD box helicase family
HPY05_12625	COG0248	Ppx GppA phosphatase
HPY05_12630	COG2205	protein histidine kinase activity
HPY05_12630	COG0784	Response regulator, receiver
HPY05_12635	COG2814	Major facilitator Superfamily
HPY05_12650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY05_12655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY05_12660	COG0511	ligase activity, forming carbon-carbon bonds
HPY05_12665	COG0439	Biotin carboxylase
HPY05_12670	COG2264	protein methyltransferase activity
HPY05_12675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY05_12680	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY05_12685	COG1609	Transcriptional regulator
HPY05_12695	COG0387	Pfam Sodium calcium exchanger
HPY05_12700	COG0129	dihydroxy-acid dehydratase activity
HPY05_12705	COG3265	gluconokinase activity
HPY05_12715	COG0800	Aldolase
HPY05_12735	COG0840	transmembrane signaling receptor activity
HPY05_12740	COG1982	Orn Lys Arg decarboxylase major
HPY05_12745	COG0531	amino acid
HPY05_12750	COG3710	Transcriptional regulator
HPY05_12755	COG0789	Transcriptional regulator
HPY05_12770	COG0151	Belongs to the GarS family
HPY05_12780	COG0776	regulation of translation
HPY05_12785	COG1253	flavin adenine dinucleotide binding
HPY05_12790	COG3068	Protein conserved in bacteria
HPY05_12800	COG1573	uracil-dna glycosylase
HPY05_12805	COG0668	transmembrane transport
HPY05_12810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY05_12815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY05_12825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY05_12865	COG0517	IMP dehydrogenase activity
HPY05_12865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY05_12875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY05_12895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY05_12910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY05_12965	COG1086	Polysaccharide biosynthesis protein
HPY05_12970	COG0438	transferase activity, transferring glycosyl groups
HPY05_13000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY05_13025	COG0859	PFAM glycosyl transferase family 9
HPY05_13035	COG1519	Transferase
HPY05_13060	COG3642	lipopolysaccharide core region biosynthetic process
HPY05_13065	COG0859	PFAM glycosyl transferase family 9
HPY05_13070	COG0463	Glycosyl transferase, family 2
HPY05_13075	COG0859	PFAM glycosyl transferase family 9
HPY05_13080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY05_13085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY05_13095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY05_13100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY05_13105	COG2003	Belongs to the UPF0758 family
HPY05_13115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY05_13125	COG1309	transcriptional regulator
HPY05_13130	COG1560	Kdo2-lipid A biosynthetic process
HPY05_13135	COG1560	Kdo2-lipid A biosynthetic process
HPY05_13140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY05_13145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY05_13150	COG1561	YicC-like family, N-terminal region
HPY05_13155	COG2862	Uncharacterized protein family, UPF0114
HPY05_13160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY05_13165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY05_13165	COG1263	PTS System
HPY05_13170	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY05_13185	COG0514	ATP-dependent DNA helicase (RecQ)
HPY05_13190	COG2962	Rard protein
HPY05_13195	COG0405	Gamma-glutamyltransferase
HPY05_13205	COG1280	lysine exporter protein (LysE YggA)
HPY05_13210	COG0210	DNA helicase
HPY05_13220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY05_13225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY05_13235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY05_13245	COG0747	negative chemotaxis
HPY05_13295	COG1309	transcriptional regulator
HPY05_13300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY05_13305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY05_13310	COG2960	long-chain fatty acid transporting porin activity
HPY05_13315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY05_13320	COG0583	DNA-binding transcription factor activity
HPY05_13390	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY05_13395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY05_13400	COG1739	Uncharacterized protein family UPF0029
HPY05_13405	COG1024	Enoyl-CoA hydratase
HPY05_13405	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY05_13410	COG0183	Belongs to the thiolase family
HPY05_13415	COG0583	DNA-binding transcription factor activity
HPY05_13420	COG2814	Major facilitator Superfamily
HPY05_13430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY05_13435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY05_13440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY05_13445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY05_13450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY05_13455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY05_13465	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY05_13470	COG3312	ion transport
HPY05_13475	COG1475	DNA binding
HPY05_13480	COG1192	Involved in chromosome partitioning
HPY05_13485	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY05_13490	COG0445	tRNA wobble uridine modification
HPY05_13495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY05_13500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY05_13505	COG0706	membrane insertase activity
HPY05_13515	COG0594	ribonuclease P activity
HPY05_13520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY05_13525	COG1126	abc transporter atp-binding protein
HPY05_13570	COG0217	transcriptional regulatory protein
HPY05_13575	COG2084	Dehydrogenase
HPY05_13590	COG2909	trisaccharide binding
HPY05_13595	COG0058	SHG alpha-glucan phosphorylase activity
HPY05_13600	COG1640	4-alpha-glucanotransferase
HPY05_13605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY05_13615	COG3501	Rhs element vgr protein
HPY05_13650	COG0471	metal ion transport
HPY05_13655	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY05_13685	COG0671	phosphoesterase, PA-phosphatase related
HPY05_13695	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY05_13705	COG1999	signal sequence binding
HPY05_13720	COG0786	glutamate:sodium symporter activity
HPY05_13740	COG1566	PFAM secretion protein HlyD family protein
HPY05_13750	COG3706	GGDEF domain
HPY05_13765	COG0813	purine-nucleoside phosphorylase activity
HPY05_13770	COG3272	Protein of unknown function (DUF1722)
HPY05_13780	COG0415	Belongs to the DNA photolyase family
HPY05_13785	COG1376	ErfK ybiS ycfS ynhG family protein
HPY05_13785	COG1388	LysM domain
HPY05_13795	COG0513	Belongs to the DEAD box helicase family
HPY05_13800	COG1770	oligopeptidase
HPY05_13830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY05_13835	COG0573	inorganic phosphate transmembrane transporter activity
HPY05_13840	COG0581	inorganic phosphate transmembrane transporter activity
HPY05_13845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY05_13865	COG0659	secondary active sulfate transmembrane transporter activity
HPY05_13875	COG0739	heme binding
HPY05_13880	COG5001	Diguanylate cyclase
HPY05_13880	COG3300	MHYT domain
HPY05_13885	COG0583	DNA-binding transcription factor activity
HPY05_13890	COG2814	Major facilitator Superfamily
HPY05_13910	COG1301	dicarboxylic acid transport
HPY05_13925	COG1342	Belongs to the UPF0251 family
HPY05_13960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY05_13965	COG0673	inositol 2-dehydrogenase activity
HPY05_13975	COG2200	EAL domain
HPY05_13975	COG2771	luxR family
HPY05_13980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY05_13990	COG0564	pseudouridine synthase activity
HPY05_14095	COG1869	D-ribose catabolic process
HPY05_14100	COG1129	ABC transporter
HPY05_14105	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY05_14110	COG1879	ABC-type sugar transport system periplasmic component
HPY05_14115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY05_14120	COG1609	Transcriptional regulator
HPY05_14130	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY05_14150	COG0584	glycerophosphoryl diester phosphodiesterase
HPY05_14155	COG2271	Major facilitator Superfamily
HPY05_14190	COG0579	oxidoreductase
HPY05_14200	COG0242	peptide deformylase activity
HPY05_14205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY05_14205	COG1017	nitric oxide dioxygenase activity
HPY05_14210	COG1320	monovalent cation:proton antiporter activity
HPY05_14215	COG2212	antiporter activity
HPY05_14235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY05_14235	COG2111	Na H antiporter
HPY05_14245	COG0589	response to stress
HPY05_14250	COG0814	amino acid
HPY05_14265	COG3530	Putative quorum-sensing-regulated virulence factor
HPY05_14275	COG5001	Diguanylate cyclase
HPY05_14275	COG5002	protein histidine kinase activity
HPY05_14280	COG1278	Cold shock
HPY05_14295	COG2304	oxidoreductase activity
HPY05_14315	COG0714	Associated with various cellular activities
HPY05_14320	COG0840	transmembrane signaling receptor activity
HPY05_14335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY05_14340	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY05_14350	COG3604	Transcriptional regulator
HPY05_14355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY05_14355	COG1017	nitric oxide dioxygenase activity
HPY05_14360	COG1278	Cold shock
HPY05_14365	COG3036	rescue of stalled ribosome
HPY05_14390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY05_14390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY05_14395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY05_14405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY05_14415	COG0516	GMP reductase activity
HPY05_14440	COG0513	Belongs to the DEAD box helicase family
HPY05_14445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY05_14450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY05_14455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY05_14460	COG0784	Response regulator, receiver
HPY05_14460	COG3437	response regulator, receiver
HPY05_14480	COG1757	Na H antiporter
HPY05_14485	COG2814	Major facilitator Superfamily
HPY05_14495	COG3706	GGDEF domain
HPY05_14500	COG3240	lipase activity
HPY05_14510	COG0840	transmembrane signaling receptor activity
HPY05_14515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY05_14520	COG5380	lipid catabolic process
HPY05_14545	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY05_14550	COG4605	iron ion homeostasis
HPY05_14555	COG4604	ABC transporter, ATP-binding protein
HPY05_14560	COG2207	Transcriptional regulator
HPY05_14575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY05_14580	COG0640	Transcriptional regulator
HPY05_14585	COG0798	PFAM Bile acid sodium symporter
HPY05_14605	COG0583	DNA-binding transcription factor activity
HPY05_14620	COG0745	RESPONSE REGULATOR receiver
HPY05_14650	COG3623	hexulose-6-phosphate isomerase
HPY05_14655	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY05_14660	COG0561	phosphatase activity
HPY05_14705	COG1335	isochorismatase
HPY05_14710	COG1741	Belongs to the pirin family
HPY05_14715	COG0583	DNA-binding transcription factor activity
HPY05_14720	COG0366	Alpha amylase catalytic
HPY05_14740	COG0745	RESPONSE REGULATOR receiver
HPY05_14745	COG5002	protein histidine kinase activity
HPY05_14765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY05_14780	COG0583	DNA-binding transcription factor activity
HPY05_14795	COG1686	Belongs to the peptidase S11 family
HPY05_14815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY05_14815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY05_14820	COG0509	glycine decarboxylation via glycine cleavage system
HPY05_14825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY05_14850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY05_14855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY05_14865	COG4977	sequence-specific DNA binding
HPY05_14935	COG0346	lactoylglutathione lyase activity
HPY05_15030	COG0384	phenazine biosynthesis protein PhzF
HPY05_15065	COG0456	acetyltransferase
HPY05_15095	COG0384	phenazine biosynthesis protein PhzF
HPY05_15245	COG2801	Transposase and inactivated derivatives
HPY05_15400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY05_15550	COG0346	lactoylglutathione lyase activity
HPY05_15560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY05_15610	COG0456	acetyltransferase
HPY05_15670	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY05_15880	COG3041	Addiction module toxin RelE StbE family
HPY05_15940	COG1418	mRNA catabolic process
HPY05_15965	COG0456	acetyltransferase
HPY05_15980	COG3549	Plasmid maintenance system killer
HPY05_15985	COG3093	addiction module antidote protein HigA
HPY05_16045	COG0456	acetyltransferase
HPY05_16050	COG4977	sequence-specific DNA binding
HPY05_16080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY05_16080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY05_16165	COG1714	RDD family
HPY05_16295	COG2357	RelA SpoT domain protein
HPY05_16615	COG0346	lactoylglutathione lyase activity
HPY05_16700	COG5642	Protein of unknown function (DUF2384)
HPY05_16720	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY05_16735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY05_16740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY05_16745	COG1621	beta-fructofuranosidase activity
HPY05_16755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY05_16755	COG1263	PTS System
HPY05_16795	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY05_16835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY05_16840	COG0583	DNA-binding transcription factor activity
HPY05_16865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY05_16890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY05_16900	COG2390	Transcriptional regulator
HPY05_16905	COG2897	thiosulfate sulfurtransferase activity
HPY05_16915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY05_16925	COG0302	gtp cyclohydrolase
HPY05_16930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY05_16930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY05_16935	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY05_16940	COG1970	mechanosensitive ion channel activity
HPY05_16945	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY05_16960	COG1011	Hydrolase
HPY05_16965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY05_16970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY05_16980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY05_16985	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY05_16990	COG3842	ATPase activity
HPY05_17010	COG3104	oligopeptide transport
HPY05_17035	COG4166	transmembrane transport
HPY05_17040	COG4174	ABC transporter (Permease)
HPY05_17045	COG4239	(ABC) transporter, permease
HPY05_17050	COG4172	Belongs to the ABC transporter superfamily
HPY05_17055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY05_17070	COG0625	glutathione transferase activity
HPY05_17090	COG2050	protein possibly involved in aromatic compounds catabolism
HPY05_17105	COG4771	TonB-dependent receptor
HPY05_17110	COG0583	DNA-binding transcription factor activity
HPY05_17115	COG1042	CoA-binding domain protein
HPY05_17115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY05_17115	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY05_17135	COG0023	Translation Initiation Factor
HPY05_17140	COG3140	Belongs to the UPF0181 family
HPY05_17155	COG0745	RESPONSE REGULATOR receiver
HPY05_17165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY05_17170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY05_17185	COG3706	GGDEF domain
HPY05_17235	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY05_17250	COG0737	Belongs to the 5'-nucleotidase family
HPY05_17255	COG3593	DNA synthesis involved in DNA repair
HPY05_17265	COG0583	DNA-binding transcription factor activity
HPY05_17270	COG2116	formate transmembrane transporter activity
HPY05_17280	COG3038	cytochrome b561
HPY05_17290	COG2200	EAL domain
HPY05_17305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY05_17315	COG2205	protein histidine kinase activity
HPY05_17320	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY05_17320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY05_17320	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY05_17320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY05_17325	COG3158	transport of potassium into the cell
HPY05_17335	COG0523	cobalamin synthesis protein
HPY05_17340	COG0038	chloride channel
HPY05_17350	COG0156	8-amino-7-oxononanoate synthase activity
HPY05_17355	COG2205	protein histidine kinase activity
HPY05_17355	COG0784	Response regulator, receiver
HPY05_17360	COG0419	ATPase involved in DNA repair
HPY05_17365	COG0420	3'-5' exonuclease activity
HPY05_17370	COG1609	Transcriptional regulator
HPY05_17375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY05_17375	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY05_17380	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY05_17385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY05_17385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY05_17385	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY05_17390	COG0189	ligase activity
HPY05_17390	COG4067	protein conserved in archaea
HPY05_17400	COG0602	queuosine metabolic process
HPY05_17405	COG1328	CTP reductase activity
HPY05_17415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY05_17420	COG0840	transmembrane signaling receptor activity
HPY05_17425	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY05_17430	COG1760	l-serine dehydratase
HPY05_17435	COG2197	response regulator
HPY05_17440	COG3850	Histidine kinase
HPY05_17445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY05_17455	COG0243	molybdopterin cofactor binding
HPY05_17475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY05_17480	COG2197	response regulator
HPY05_17485	COG3851	Histidine kinase
HPY05_17490	COG2271	Major facilitator Superfamily
HPY05_17495	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY05_17505	COG3842	ATPase activity
HPY05_17510	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY05_17520	COG0183	Belongs to the thiolase family
HPY05_17530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY05_17535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY05_17550	COG3706	GGDEF domain
HPY05_17555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY05_17565	COG1979	alcohol dehydrogenase
HPY05_17580	COG4191	Histidine kinase
HPY05_17590	COG2271	Major facilitator Superfamily
HPY05_17595	COG0469	pyruvate kinase activity
HPY05_17605	COG1879	ABC-type sugar transport system periplasmic component
HPY05_17610	COG1803	Methylglyoxal synthase
HPY05_17615	COG1335	isochorismatase
HPY05_17620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY05_17625	COG0210	DNA helicase
HPY05_17630	COG1289	transmembrane transporter activity
HPY05_17660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY05_17665	COG4149	molybdate abc transporter
HPY05_17670	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY05_17675	COG1492	cobalamin metabolic process
HPY05_17715	COG1917	Cupin 2, conserved barrel domain protein
HPY05_17715	COG4977	sequence-specific DNA binding
HPY05_17720	COG4771	TonB-dependent receptor
HPY05_17725	COG2814	Major facilitator Superfamily
HPY05_17755	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY05_17760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY05_17780	COG1132	(ABC) transporter
HPY05_17785	COG1132	(ABC) transporter
HPY05_17795	COG5002	protein histidine kinase activity
HPY05_17795	COG0784	Response regulator, receiver
HPY05_17800	COG1879	ABC-type sugar transport system periplasmic component
HPY05_17810	COG2827	Endonuclease containing a URI domain
HPY05_17825	COG2926	Belongs to the UPF0265 family
HPY05_17840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY05_17845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY05_17855	COG0247	lactate metabolic process
HPY05_17860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY05_17865	COG3118	belongs to the thioredoxin family
HPY05_17890	COG4160	amino acid transport
HPY05_17895	COG4215	(ABC) transporter
HPY05_17900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY05_17905	COG1126	abc transporter atp-binding protein
HPY05_17915	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY05_17925	COG0494	nUDIX hydrolase
HPY05_17930	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY05_17940	COG1309	transcriptional regulator
HPY05_17945	COG0513	Belongs to the DEAD box helicase family
HPY05_17950	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY05_17955	COG0814	amino acid
HPY05_17960	COG0840	transmembrane signaling receptor activity
HPY05_17965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY05_17970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY05_17980	COG1984	allophanate hydrolase subunit 2
HPY05_17995	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY05_18000	COG4181	ATPase activity
HPY05_18010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY05_18015	COG1716	ATPase activity
HPY05_18015	COG5001	Diguanylate cyclase
HPY05_18025	COG0484	heat shock protein binding
HPY05_18040	COG0546	phosphoglycolate phosphatase activity
HPY05_18055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY05_18060	COG1368	sulfuric ester hydrolase activity
HPY05_18070	COG0513	Belongs to the DEAD box helicase family
HPY05_18085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY05_18095	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY05_18100	COG3397	chitin binding
HPY05_18105	COG3227	Zinc metalloprotease (Elastase)
HPY05_18115	COG0010	Belongs to the arginase family
HPY05_18120	COG1166	arginine decarboxylase activity
HPY05_18130	COG2239	Acts as a magnesium transporter
HPY05_18135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY05_18140	COG0459	protein refolding
HPY05_18150	COG0527	aspartate kinase activity
HPY05_18155	COG0662	Cupin 2, conserved barrel domain protein
HPY05_18160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY05_18165	COG0456	acetyltransferase
HPY05_18170	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY05_18175	COG3186	Phenylalanine-4-hydroxylase
HPY05_18180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY05_18195	COG2264	protein methyltransferase activity
HPY05_18220	COG1253	flavin adenine dinucleotide binding
HPY05_18225	COG1765	OsmC-like protein
HPY05_18260	COG1252	NADH dehydrogenase
HPY05_18270	COG3706	GGDEF domain
HPY05_18280	COG3279	Response regulator of the LytR AlgR family
HPY05_18285	COG3275	phosphorelay sensor kinase activity
HPY05_18300	COG0577	efflux transmembrane transporter activity
HPY05_18300	COG1136	(ABC) transporter
HPY05_18305	COG1136	(ABC) transporter
HPY05_18315	COG4989	oxidoreductase activity
HPY05_18320	COG0366	Alpha amylase catalytic
HPY05_18330	COG2067	long-chain fatty acid transport protein
HPY05_18335	COG2267	carboxylic ester hydrolase activity
HPY05_18345	COG3227	Zinc metalloprotease (Elastase)
HPY05_18350	COG3047	cAMP biosynthetic process
HPY05_18360	COG1686	Belongs to the peptidase S11 family
HPY05_18365	COG0557	exoribonuclease II activity
HPY05_18370	COG1278	Cold shock
HPY05_18380	COG3048	D-serine ammonia-lyase activity
HPY05_18390	COG0583	DNA-binding transcription factor activity
HPY05_18410	COG2801	Transposase and inactivated derivatives
HPY05_18415	COG5002	protein histidine kinase activity
HPY05_18435	COG0582	viral genome integration into host DNA
HPY05_18455	COG1063	alcohol dehydrogenase
HPY05_18480	COG0346	lactoylglutathione lyase activity
HPY05_18500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY05_18505	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY05_18510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY05_18515	COG0363	glucosamine-6-phosphate deaminase activity
HPY05_18520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY05_18545	COG1929	Belongs to the glycerate kinase type-1 family
HPY05_18550	COG2610	gluconate transmembrane transporter activity
HPY05_18555	COG3835	regulator
HPY05_18565	COG0748	coenzyme F420 binding
HPY05_18570	COG3721	Heme iron utilization protein
HPY05_18580	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY05_18585	COG0811	peptide transport
HPY05_18590	COG0848	biopolymer transport protein
HPY05_18600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY05_18605	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY05_18640	COG0633	Ferredoxin
HPY05_18640	COG3217	Mosc domain protein beta barrel domain protein
HPY05_18640	COG0633	Ferredoxin
HPY05_18640	COG3217	Mosc domain protein beta barrel domain protein
HPY05_18645	COG0418	dihydroorotase activity
HPY05_18650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY05_18655	COG2354	Protein conserved in bacteria
HPY05_18665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY05_18670	COG1278	Cold shock
HPY05_18695	COG3706	GGDEF domain
HPY05_18700	COG1349	DNA-binding transcription factor activity
HPY05_18715	COG3833	ABC-type maltose transport systems, permease component
HPY05_18720	COG1175	transmembrane transport
HPY05_18730	COG3842	ATPase activity
HPY05_18735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY05_18750	COG0393	Putative heavy-metal-binding
HPY05_18760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY05_18765	COG0784	Response regulator, receiver
HPY05_18765	COG0835	chemotaxis
HPY05_18770	COG1846	Transcriptional regulator
HPY05_18775	COG3706	GGDEF domain
HPY05_18810	COG0583	DNA-binding transcription factor activity
HPY05_18815	COG5001	Diguanylate cyclase
HPY05_18825	COG1741	Belongs to the pirin family
HPY05_18830	COG3123	guanosine phosphorylase activity
HPY05_18840	COG2211	Major facilitator Superfamily
HPY05_18845	COG0840	transmembrane signaling receptor activity
HPY05_18850	COG1067	ATP-dependent peptidase activity
HPY05_18860	COG4172	Belongs to the ABC transporter superfamily
HPY05_18880	COG0583	DNA-binding transcription factor activity
HPY05_18890	COG1620	l-lactate permease
HPY05_18905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY05_18915	COG0840	transmembrane signaling receptor activity
HPY05_18935	COG2258	MOSC domain
HPY05_18940	COG0513	Belongs to the DEAD box helicase family
HPY05_18950	COG1132	(ABC) transporter
HPY05_18960	COG1902	pentaerythritol trinitrate reductase activity
HPY05_18970	COG1280	lysine exporter protein (LysE YggA)
HPY05_18975	COG2207	Transcriptional regulator
HPY05_18995	COG1846	Transcriptional regulator
HPY05_19000	COG1764	response to oxidative stress
HPY05_19005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY05_19010	COG0697	spore germination
HPY05_19020	COG0700	Nucleoside recognition
HPY05_19025	COG3366	ferrous iron transmembrane transporter activity
HPY05_19030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY05_19040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY05_19045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY05_19050	COG2259	Doxx family
HPY05_19075	COG0363	glucosamine-6-phosphate deaminase activity
HPY05_19090	COG4580	involved in the transport of maltose and maltodextrins
HPY05_19105	COG0840	transmembrane signaling receptor activity
HPY05_19120	COG0840	transmembrane signaling receptor activity
HPY05_19125	COG5001	Diguanylate cyclase
HPY05_19135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY05_19140	COG1126	abc transporter atp-binding protein
HPY05_19150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY05_19155	COG4597	amino acid ABC transporter
HPY05_19160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY05_19165	COG2213	PTS system mannitol-specific
HPY05_19165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY05_19170	COG0246	Mannitol dehydrogenase
HPY05_19175	COG3722	fumarate hydratase activity
HPY05_19180	COG0673	inositol 2-dehydrogenase activity
HPY05_19210	COG2910	NAD(P)H-binding
HPY05_19220	COG0840	transmembrane signaling receptor activity
HPY05_19225	COG4221	oxidoreductase activity
HPY05_19235	COG1901	pseudouridine methyltransferase
HPY05_19250	COG0531	amino acid
HPY05_19255	COG1982	Orn Lys Arg decarboxylase major
HPY05_19265	COG2197	response regulator
HPY05_19305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY05_19330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY05_19395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY05_19400	COG0840	transmembrane signaling receptor activity
HPY05_19405	COG0835	chemotaxis
HPY05_19410	COG0835	chemotaxis
HPY05_19415	COG0643	Histidine kinase
HPY05_19415	COG2198	Histidine kinase
HPY05_19430	COG0747	negative chemotaxis
HPY05_19435	COG0601	transmembrane transport
HPY05_19440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY05_19445	COG4608	Belongs to the ABC transporter superfamily
HPY05_19450	COG2194	sulfuric ester hydrolase activity
HPY05_19455	COG0642	Histidine kinase
HPY05_19460	COG0745	RESPONSE REGULATOR receiver
HPY05_19470	COG4221	oxidoreductase activity
HPY05_19490	COG1444	tRNA N-acetyltransferase activity
HPY05_19495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY05_19665	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY05_19790	COG0653	protein targeting
HPY05_19820	COG0776	regulation of translation
HPY05_19935	COG0754	glutathionylspermidine amidase activity
HPY05_19955	COG1842	Phage shock protein A
HPY05_19990	COG2026	Addiction module toxin, RelE StbE family
HPY05_20125	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY05_20245	COG5001	Diguanylate cyclase
HPY05_20245	COG3300	MHYT domain
HPY05_20600	COG1199	ATP-dependent helicase activity
HPY05_20640	COG0210	DNA helicase
HPY05_20690	COG4206	TonB-dependent receptor
HPY05_20770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY05_20845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY05_20860	COG0681	Belongs to the peptidase S26 family
HPY05_20885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY05_21000	COG1475	DNA binding