locus-tag	class	description
HPY09_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPY09_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY09_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPY09_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY09_00030	ENOG4108ZNX	Heat shock protein
HPY09_00035	ENOG4105JKW	Valine--pyruvate aminotransferase
HPY09_00040	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HPY09_00045	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HPY09_00060	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HPY09_00070	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HPY09_00075	ENOG4105C7B	Threonine dehydratase
HPY09_00080	ENOG4105C01	Dihydroxy-acid dehydratase
HPY09_00085	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPY09_00100	ENOG4105C0P	Mg chelatase subunit ChlI
HPY09_00105	ENOG4106HNH	Acyl-transferase
HPY09_00110	ENOG4108Z33	Thiol disulfide Interchange Protein
HPY09_00115	ENOG4105E27	serine threonine protein kinase
HPY09_00125	ENOG4105PC1	Conserved Protein
HPY09_00135	ENOG4108N23	SpoOM-related protein
HPY09_00140	ENOG4108UT2	hemolysin iii
HPY09_00150	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY09_00155	ENOG4105C1A	potassium transporter peripheral membrane
HPY09_00160	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HPY09_00175	ENOG4108WZM	domain protein
HPY09_00180	ENOG4105C79	DNA protecting protein DprA
HPY09_00185	ENOG4108RPN	Protein smg homolog
HPY09_00190	ENOG4108WI1	Dna topoisomerase
HPY09_00195	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HPY09_00200	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HPY09_00205	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY09_00210	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HPY09_00215	ENOG4105E2X	shikimate dehydrogenase
HPY09_00225	ENOG4108Z0R	Transferase
HPY09_00260	ENOG4105WMR	Protein CrcB homolog
HPY09_00265	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HPY09_00275	ENOG4105D06	uba thif-type nad fad binding protein
HPY09_00280	ENOG4105WHD	thiamine biosynthesis protein ThiS
HPY09_00285	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPY09_00290	ENOG4105D41	biosynthesis protein thiH
HPY09_00295	ENOG4105DC7	peptidase M24
HPY09_00295	ENOG4105DC7	peptidase M24
HPY09_00300	ENOG4105G2Y	Transcriptional regulator
HPY09_00305	ENOG4105CNH	Multidrug resistance protein MdtL
HPY09_00315	ENOG4108VVK	transcriptional Regulator, AsnC
HPY09_00320	ENOG4105BZU	Histidine kinase
HPY09_00335	ENOG4105EMK	carboxylate amino acid amine transporter
HPY09_00340	ENOG4108M6U	Universal stress protein A
HPY09_00345	ENOG41090A1	ferritin
HPY09_00350	ENOG4108V6B	universal stress protein B
HPY09_00355	ENOG4105CBX	hi0933 family
HPY09_00365	ENOG4105CGY	Dna recombination protein
HPY09_00370	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPY09_00375	ENOG4105JC1	sterol-binding domain protein
HPY09_00385	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY09_00390	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPY09_00395	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPY09_00400	ENOG4105CA0	peroxidase
HPY09_00405	ENOG4107R73	Mate efflux family protein
HPY09_00415	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPY09_00420	ENOG4105E55	glycerol-3-phosphate acyltransferase
HPY09_00425	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HPY09_00430	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HPY09_00435	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY09_00440	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_00450	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HPY09_00455	ENOG4105F8V	Hydrolase, tatD family
HPY09_00460	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPY09_00470	ENOG4105C2M	dna polymerase I
HPY09_00480	ENOG4106RE7	Cytochrome
HPY09_00490	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HPY09_00495	ENOG4105XCT	Protein of unknown function (DUF2489)
HPY09_00500	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY09_00505	ENOG410601J	HemY protein
HPY09_00510	ENOG4105ECF	c-methyltransferase
HPY09_00515	ENOG41076E6	Uroporphyrinogen-III Synthase
HPY09_00520	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPY09_00525	ENOG4107T0K	Adenylate cyclase
HPY09_00530	ENOG4105XQ6	frataxin-like protein
HPY09_00540	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPY09_00545	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPY09_00550	ENOG4105CT0	Protein of unknown function, DUF484
HPY09_00555	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY09_00560	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HPY09_00565	ENOG4105BZU	Histidine kinase
HPY09_00580	ENOG4105DQF	Hydrolase
HPY09_00585	ENOG4108EUD	Lysophospholipase
HPY09_00590	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY09_00595	ENOG4105D58	Diguanylate phosphodiesterase
HPY09_00600	ENOG4108RMU	ferritin dps family protein
HPY09_00630	ENOG4106H78	methyltransferase
HPY09_00635	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPY09_00640	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPY09_00645	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HPY09_00650	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY09_00655	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HPY09_00670	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HPY09_00675	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY09_00680	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HPY09_00685	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPY09_00750	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPY09_00755	ENOG4105BZU	Histidine kinase
HPY09_00760	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_00765	ENOG4105CUX	Signal transduction histidine kinase
HPY09_00775	ENOG4105C5F	glutamine synthetase
HPY09_00785	ENOG4105CI3	gtp-binding protein typa
HPY09_00795	ENOG4107S2Z	UPF0761 membrane protein
HPY09_00800	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPY09_00805	ENOG4105SUU	thioesterase domain
HPY09_00815	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HPY09_00820	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HPY09_00825	ENOG4105VEJ	Heat shock protein
HPY09_00830	ENOG4108XKW	General secretion pathway protein C
HPY09_00840	ENOG4107QHF	type ii secretion system protein e
HPY09_00845	ENOG4105D7Q	type ii secretion system
HPY09_00850	ENOG4108VAU	general secretion pathway protein G
HPY09_00855	ENOG4105VWV	general secretion pathway protein h
HPY09_00860	ENOG4105X5Z	General secretion pathway protein I
HPY09_00865	ENOG4108WWZ	General secretion pathway protein J
HPY09_00870	ENOG4108RTD	type II secretion system protein K
HPY09_00875	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HPY09_00880	ENOG4105U1E	general secretion pathway protein M
HPY09_00885	ENOG4105PIC	general secretion pathway protein N
HPY09_00890	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HPY09_00895	ENOG4107RK2	ADP-ribose diphosphatase NudE
HPY09_00905	ENOG4105MJ2	Competence protein
HPY09_00915	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY09_00925	ENOG4105BZM	domain protein
HPY09_00930	ENOG4108RRZ	Transcription elongation factor GreB
HPY09_00935	ENOG4108KHX	Diguanylate cyclase
HPY09_00945	ENOG4105E0F	Histidine kinase
HPY09_00950	ENOG4105C2W	permease
HPY09_00955	ENOG4105CB5	ATP-dependent DNA helicase recG
HPY09_00960	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY09_00965	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HPY09_00970	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPY09_00975	ENOG4105EX9	Membrane
HPY09_00980	ENOG4107QN1	sodium solute
HPY09_01000	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HPY09_01010	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY09_01015	ENOG4108IJ0	Aspartate ammonia-lyase
HPY09_01020	ENOG4105BZU	Histidine kinase
HPY09_01025	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HPY09_01030	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPY09_01040	ENOG4105E0F	Histidine kinase
HPY09_01045	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HPY09_01055	ENOG41076HS	cation diffusion facilitator family transporter
HPY09_01060	ENOG4105CTQ	phosphohexokinase
HPY09_01065	ENOG4105CBT	Fructose-1,6-bisphosphatase
HPY09_01070	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HPY09_01075	ENOG4105SYT	Methylenetetrahydrofolate reductase
HPY09_01080	ENOG4105CFH	Aspartokinase
HPY09_01090	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HPY09_01095	ENOG4105C6K	Malic enzyme
HPY09_01100	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPY09_01105	ENOG4105C25	Primosomal protein n'
HPY09_01110	ENOG4105ETE	Transcriptional regulator (LacI family
HPY09_01115	ENOG41063M6	Cell Division Protein
HPY09_01120	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HPY09_01125	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HPY09_01130	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HPY09_01135	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY09_01145	ENOG4105CP7	Triose-phosphate isomerase
HPY09_01170	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY09_01175	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY09_01185	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HPY09_01190	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY09_01200	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HPY09_01205	ENOG4105E33	succinate dehydrogenase
HPY09_01215	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HPY09_01220	ENOG4107YZP	Rhodanese domain protein
HPY09_01225	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HPY09_01230	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPY09_01235	ENOG4105D7W	serine acetyltransferase
HPY09_01245	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HPY09_01250	ENOG4105CWC	Acetylornithine deacetylase
HPY09_01255	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPY09_01260	ENOG4105CAS	nag kinase
HPY09_01265	ENOG4105CDH	Citrulline--aspartate ligase
HPY09_01270	ENOG4105CH7	arginosuccinase
HPY09_01280	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY09_01285	ENOG4105EHV	domain protein
HPY09_01295	ENOG4108JQC	penicillin-binding protein 1A
HPY09_01320	ENOG4105E4G	Type IV pilus
HPY09_01325	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPY09_01330	ENOG4105D49	3-dehydroquinate synthase
HPY09_01340	ENOG4105DFE	Dna adenine methylase
HPY09_01345	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPY09_01350	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY09_01355	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPY09_01375	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HPY09_01380	ENOG4105DDQ	anthranilate synthase
HPY09_01385	ENOG4105C8Y	Acetylornithine aminotransferase
HPY09_01395	ENOG4105C26	Dehydrogenase
HPY09_01405	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HPY09_01410	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HPY09_01420	ENOG4105DNZ	Alpha Beta Hydrolase
HPY09_01430	ENOG4105C5H	ABC transporter
HPY09_01435	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPY09_01450	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HPY09_01455	ENOG4105D44	asparaginase
HPY09_01460	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY09_01465	ENOG4108UV7	flagellar protein motX
HPY09_01470	ENOG4105E68	Sulfatase
HPY09_01475	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY09_01480	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPY09_01485	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPY09_01490	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPY09_01495	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPY09_01500	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPY09_01505	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY09_01510	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPY09_01515	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPY09_01520	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPY09_01525	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HPY09_01530	ENOG41083MP	50s ribosomal protein l29
HPY09_01535	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HPY09_01540	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPY09_01545	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPY09_01550	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY09_01555	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPY09_01560	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HPY09_01565	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HPY09_01570	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HPY09_01575	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPY09_01580	ENOG4105VPB	50S ribosomal protein L30
HPY09_01590	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HPY09_01600	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY09_01605	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPY09_01610	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPY09_01615	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY09_01620	ENOG4108ZT0	50S ribosomal protein l17
HPY09_01630	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY09_01635	ENOG4108UBT	opacity-associated protein
HPY09_01640	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY09_01645	ENOG4107YB6	acetyltransferase, (GNAT) family
HPY09_01650	ENOG4105C1J	atp-dependent rna helicase
HPY09_01660	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HPY09_01665	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPY09_01670	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HPY09_01675	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HPY09_01680	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HPY09_01700	ENOG4105C19	ABC transporter
HPY09_01715	ENOG4108UUE	Transcriptional regulator
HPY09_01720	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPY09_01725	ENOG4105CFU	surface antigen
HPY09_01735	ENOG41066HZ	AIG2-like family
HPY09_01740	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPY09_01750	ENOG4105DFU	Cell wall formation (By similarity)
HPY09_01755	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HPY09_01765	ENOG4106SMU	thiamine transporter membrane protein
HPY09_01770	ENOG4107T0D	ABC, transporter
HPY09_01775	ENOG4105N42	UPF0307 protein
HPY09_01780	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HPY09_01785	ENOG4105CJW	magnesium transporter
HPY09_01790	ENOG41080Z8	PHOSPHOCARRIER protein
HPY09_01795	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPY09_01800	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HPY09_01805	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HPY09_01810	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY09_01815	ENOG4108IUZ	ABC transporter
HPY09_01820	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HPY09_01830	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HPY09_01835	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY09_01845	ENOG4105DHJ	ABC, transporter
HPY09_01850	ENOG4105CY3	ABC transporter, permease
HPY09_01855	ENOG4107PE3	Mammalian cell entry related domain protein
HPY09_01860	ENOG4105E3I	toluene tolerance
HPY09_01870	ENOG4105VFK	BolA family
HPY09_01875	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPY09_01880	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HPY09_01885	ENOG4105KME	endoribonuclease L-psp
HPY09_01895	ENOG4105CXT	aspartate transcarbamylase
HPY09_01905	ENOG4108IAB	Phoh family
HPY09_01920	ENOG4105D3G	Pseudouridine synthase
HPY09_01925	ENOG4105C5I	Dehydrogenase
HPY09_01930	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPY09_01935	ENOG4105MYG	DNA polymerase iii, chi subunit
HPY09_01940	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY09_01945	ENOG4108M8S	permease YjgP YjgQ family protein
HPY09_01950	ENOG4108K5H	permease YjgP YjgQ family protein
HPY09_01965	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY09_02005	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY09_02010	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY09_02015	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPY09_02045	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY09_02050	ENOG4105C7K	acetolactate synthase
HPY09_02055	ENOG4108ZP8	Acetolactate synthase small subunit
HPY09_02060	ENOG4108JQ1	Dehydrogenase
HPY09_02065	ENOG4105E66	phosphoriboisomerase A
HPY09_02070	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HPY09_02080	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HPY09_02090	ENOG4105D0A	hydroxylase
HPY09_02095	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY09_02110	ENOG4105Y75	tpr repeat protein
HPY09_02120	ENOG4108IYU	L-aspartate oxidase
HPY09_02125	ENOG4105EMN	RNA polymerase sigma factor
HPY09_02140	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
HPY09_02145	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPY09_02150	ENOG4105C3F	Signal peptidase i
HPY09_02155	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPY09_02160	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPY09_02165	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HPY09_02170	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HPY09_02175	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HPY09_02195	ENOG4105BZU	Histidine kinase
HPY09_02205	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY09_02210	ENOG4105DXN	mazG family
HPY09_02215	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HPY09_02220	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPY09_02225	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HPY09_02240	ENOG4106MWK	domain protein
HPY09_02245	ENOG4105CJ3	phosphate transporter
HPY09_02250	ENOG4107IX6	phosphate transport regulator
HPY09_02255	ENOG4105I7R	Adenylate cyclase
HPY09_02260	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_02265	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPY09_02275	ENOG4105DFG	type I secretion outer membrane protein
HPY09_02280	ENOG41087AY	ADP-Ribose pyrophosphatase
HPY09_02285	ENOG4108SX3	cytoplasmic protein
HPY09_02290	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HPY09_02295	ENOG4105IPS	esterase
HPY09_02300	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY09_02305	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY09_02315	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HPY09_02320	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPY09_02325	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HPY09_02330	ENOG4105D7Q	type ii secretion system
HPY09_02335	ENOG4107QHF	type ii secretion system protein e
HPY09_02345	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HPY09_02355	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY09_02360	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY09_02365	ENOG4105T95	Thiol disulfide interChange protein
HPY09_02370	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HPY09_02375	ENOG41073TP	transcriptional regulator
HPY09_02380	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPY09_02385	ENOG4107QSN	dihydrolipoamide acetyltransferase
HPY09_02390	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY09_02405	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPY09_02410	ENOG4105CJN	penicillin-binding protein
HPY09_02415	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPY09_02420	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HPY09_02430	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPY09_02440	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HPY09_02445	ENOG4105DFU	Cell wall formation (By similarity)
HPY09_02450	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HPY09_02455	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HPY09_02460	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPY09_02465	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY09_02475	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY09_02480	ENOG4105M6F	mutator MutT protein
HPY09_02485	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPY09_02495	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HPY09_02500	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPY09_02520	ENOG4105EJ9	Membrane
HPY09_02525	ENOG4105VP0	transcriptional regulator, lysR family
HPY09_02530	ENOG4105EN6	Membrane
HPY09_02535	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HPY09_02545	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPY09_02555	ENOG4105BZ8	glutamate synthase
HPY09_02560	ENOG4105CBC	glutamate synthase
HPY09_02585	ENOG4105BZU	Histidine kinase
HPY09_02590	ENOG41065U4	response regulator
HPY09_02600	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY09_02620	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPY09_02625	ENOG4105D98	threonine synthase
HPY09_02630	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HPY09_02635	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HPY09_02640	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPY09_02655	ENOG4105BZG	amino acid carrier protein
HPY09_02660	ENOG4105D1Q	UPF0246 protein
HPY09_02670	ENOG4105EYA	deoxyribonuclease
HPY09_02675	ENOG4105D9N	nucleoside
HPY09_02685	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HPY09_02690	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HPY09_02695	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HPY09_02700	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY09_02710	ENOG4105EAC	phosphoserine phosphatase
HPY09_02720	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPY09_02725	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY09_02730	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY09_02735	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY09_02745	ENOG4105CNT	hydrolase family 2
HPY09_02750	ENOG41060NJ	transcriptional regulator
HPY09_02755	ENOG4108Y51	tRNA-binding protein
HPY09_02770	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY09_02775	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY09_02785	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HPY09_02790	ENOG4105X2V	dna damage-inducible protein
HPY09_02805	ENOG4105DSY	exodeoxyribonuclease V, gamma
HPY09_02810	ENOG4107QKA	exodeoxyribonuclease V beta
HPY09_02815	ENOG4107QYX	exodeoxyribonuclease v alpha
HPY09_02825	ENOG4107QZM	n-acetylglutamate synthase
HPY09_02835	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HPY09_02840	ENOG4105CUZ	uba thif-type nad fad binding protein
HPY09_02845	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HPY09_02850	ENOG4105C9B	Cysteine desulfurase
HPY09_02855	ENOG4107S0N	DJ-1 family
HPY09_02860	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPY09_02865	ENOG4105DRB	nucleoside-specific channel-forming protein
HPY09_02875	ENOG4105K6V	RNA polymerase
HPY09_02885	ENOG4105EYM	Major Facilitator superfamily
HPY09_02890	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY09_02900	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY09_02905	ENOG4105M85	Bola protein
HPY09_02910	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY09_02915	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY09_02920	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY09_02930	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY09_02935	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HPY09_02940	ENOG4105CJ2	(LipO)protein
HPY09_02960	ENOG4105BZU	Histidine kinase
HPY09_02965	ENOG4105C8J	)-transporter
HPY09_02970	ENOG4105VNT	transposase (IS4 family) protein
HPY09_02980	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY09_02985	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY09_02990	ENOG4105CIN	aminoacyl-histidine dipeptidase
HPY09_02995	ENOG4105C7N	Xanthine uracil vitamin C permease
HPY09_03000	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HPY09_03005	ENOG4108DJV	Fermentation respiration switch protein
HPY09_03010	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HPY09_03015	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPY09_03020	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPY09_03025	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPY09_03030	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY09_03045	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HPY09_03050	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HPY09_03055	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HPY09_03060	ENOG4108ZAI	phosphatidylglycerophosphatase a
HPY09_03065	ENOG4108T8E	UPF0325 protein
HPY09_03070	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HPY09_03075	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPY09_03080	ENOG4105CE9	30S ribosomal protein S2
HPY09_03085	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HPY09_03090	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPY09_03095	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPY09_03100	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPY09_03105	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPY09_03110	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPY09_03115	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPY09_03125	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HPY09_03130	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY09_03135	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HPY09_03140	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY09_03145	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY09_03150	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY09_03155	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPY09_03160	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HPY09_03165	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HPY09_03170	ENOG4105N7H	Cytochrome
HPY09_03175	ENOG4105PY6	Phenolic acid decarboxylase
HPY09_03180	ENOG4108YZA	Nitrogen regulatory protein pii
HPY09_03185	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HPY09_03190	ENOG4105E9H	Lytic Murein transglycosylase
HPY09_03195	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPY09_03200	ENOG4105D1A	Methyltransferase
HPY09_03205	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY09_03210	ENOG4107RZZ	dna polymerase iii epsilon subunit
HPY09_03220	ENOG4107QPN	acyl-Coa dehydrogenase
HPY09_03225	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY09_03230	ENOG4105E7A	Glutamine amidotransferase
HPY09_03235	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HPY09_03240	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPY09_03245	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HPY09_03250	ENOG4105BZU	Histidine kinase
HPY09_03255	ENOG4105FE9	pseudouridine synthase
HPY09_03260	ENOG4108DG9	Smr protein MutS2
HPY09_03280	ENOG4105E2D	ec 3.2.1.52
HPY09_03290	ENOG4105C59	p-type ATPase
HPY09_03295	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPY09_03300	ENOG4105UYK	outer membrane protein a
HPY09_03310	ENOG4107RBR	Receptor
HPY09_03315	ENOG4105Q26	Siderophore-interacting protein
HPY09_03320	ENOG4105C0W	non-ribosomal peptide synthetase
HPY09_03355	ENOG4107R88	Chemotaxis protein (CheV)
HPY09_03360	ENOG4105BZU	Histidine kinase
HPY09_03365	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPY09_03370	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPY09_03375	ENOG4105W00	Flagellar hook capping protein
HPY09_03380	ENOG4105BZE	flagellar hook protein, FlgE
HPY09_03385	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPY09_03390	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPY09_03395	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY09_03400	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY09_03405	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPY09_03420	ENOG4105I03	Flagellin
HPY09_03425	ENOG4105I03	Flagellin
HPY09_03510	ENOG4105C3G	gtp-binding protein
HPY09_03515	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPY09_03520	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPY09_03525	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPY09_03530	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HPY09_03535	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPY09_03540	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPY09_03545	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPY09_03550	ENOG4108YY7	Invasion gene expression up-regulator SirB
HPY09_03555	ENOG41063JG	Transcriptional regulator
HPY09_03560	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY09_03565	ENOG4105CGH	5'-nucleotidase
HPY09_03570	ENOG4108Z66	YbaK ebsC protein
HPY09_03575	ENOG4105C2W	permease
HPY09_03590	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HPY09_03595	ENOG4105K89	arsenate reductase
HPY09_03600	ENOG4105ERG	peptidase m48, ste24p
HPY09_03615	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_03620	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY09_03635	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY09_03655	ENOG4105KUZ	arsenate reductase
HPY09_03670	ENOG4105QZU	Inner membrane protein YfeZ
HPY09_03675	ENOG4105EZR	dyp-type peroxidase family protein
HPY09_03680	ENOG4105I03	Flagellin
HPY09_03685	ENOG4105I03	Flagellin
HPY09_03690	ENOG4105I03	Flagellin
HPY09_03695	ENOG41063QE	flagellar protein FlaG
HPY09_03700	ENOG4107W9T	flagellar hook-associated
HPY09_03710	ENOG4105MQ3	flagellar protein FliS
HPY09_03720	ENOG4105BZU	Histidine kinase
HPY09_03730	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HPY09_03735	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPY09_03740	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY09_03745	ENOG4105W2B	Flagellar assembly protein
HPY09_03750	ENOG4108JIR	Flagellum-specific ATP synthase
HPY09_03770	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY09_03775	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY09_03780	ENOG4105DD5	Flagellar motor switch protein
HPY09_03785	ENOG4105VTB	flagellar biosynthesis protein fliO
HPY09_03790	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPY09_03795	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPY09_03800	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPY09_03805	ENOG4105D00	flagellar biosynthetic protein flhB
HPY09_03810	ENOG4108DG9	Smr protein MutS2
HPY09_03815	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HPY09_03820	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPY09_03825	ENOG4105EN6	Membrane
HPY09_03830	ENOG4108BPE	-transporting atpase
HPY09_03835	ENOG4105MH2	YfcL protein
HPY09_03840	ENOG4105Q8W	reductase
HPY09_03845	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HPY09_03850	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY09_03855	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HPY09_03860	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY09_03865	ENOG41090R7	Ferric uptake
HPY09_03875	ENOG4105CMU	LysR family (Transcriptional regulator
HPY09_03880	ENOG4105VAW	lrga family
HPY09_03885	ENOG41067MG	lrgb family
HPY09_03890	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY09_03900	ENOG4105EV9	Alpha Beta Hydrolase
HPY09_03905	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HPY09_03910	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HPY09_03920	ENOG4107QNR	UPF0135 protein
HPY09_03925	ENOG4105BZN	citrate synthase
HPY09_03930	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HPY09_03935	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HPY09_03940	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HPY09_03945	ENOG4105E33	succinate dehydrogenase
HPY09_03950	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPY09_03955	ENOG4105C7S	Dehydrogenase
HPY09_03960	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HPY09_03965	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HPY09_03970	ENOG4105FAV	ABC, transporter
HPY09_03975	ENOG4105FDK	ABC transporter
HPY09_03980	ENOG4105NXV	High-affinity zinc uptake system protein
HPY09_03985	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HPY09_03990	ENOG4105XFK	Ferrous iron transport protein A
HPY09_04010	ENOG4105C75	arginyL-tRNA synthetase
HPY09_04020	ENOG4108JQM	Insulinase (Peptidase family M16)
HPY09_04025	ENOG4108BY2	phosphohistidine phosphatase
HPY09_04030	ENOG4105D7B	Flagellar biosynthesis protein flha
HPY09_04035	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HPY09_04045	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY09_04050	ENOG4108VYJ	response regulator receiver protein
HPY09_04055	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HPY09_04065	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY09_04070	ENOG4107QJE	Chromosome Partitioning Protein
HPY09_04080	ENOG4108V3W	Chemotaxis protein, CheW
HPY09_04090	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HPY09_04095	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HPY09_04100	ENOG41060IM	Heme exporter protein
HPY09_04105	ENOG41067VX	Heme exporter protein
HPY09_04110	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HPY09_04115	ENOG4105DA4	cytochrome c-type biogenesis protein
HPY09_04120	ENOG4107QX9	Thiol disulfide interChange protein
HPY09_04125	ENOG4108M1T	Cytochrome c-type biogenesis protein
HPY09_04135	ENOG410903C	(LipO)protein
HPY09_04150	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY09_04155	ENOG4105M2J	Glutaredoxin
HPY09_04160	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY09_04165	ENOG4105DGU	Histone deacetylase
HPY09_04180	ENOG4105E68	Sulfatase
HPY09_04185	ENOG4105YDX	UPF0352 protein
HPY09_04190	ENOG4106V8H	Nucleoid-associated protein
HPY09_04200	ENOG4105DFD	Na H antiporter
HPY09_04205	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY09_04210	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPY09_04215	ENOG4105C0A	alcohol dehydrogenase
HPY09_04225	ENOG4105CHH	sulfate transporter
HPY09_04230	ENOG4105C03	ribonuclease
HPY09_04235	ENOG4105EI2	Pseudouridine synthase
HPY09_04240	ENOG4108UHJ	MAF-like protein
HPY09_04245	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HPY09_04250	ENOG4105VGS	50s ribosomal protein l32
HPY09_04255	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HPY09_04260	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY09_04265	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HPY09_04270	ENOG4105CHR	reductase
HPY09_04275	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPY09_04280	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY09_04285	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HPY09_04290	ENOG4105HHA	aminodeoxychorismate lyase
HPY09_04295	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPY09_04300	ENOG4107QRG	dna polymerase iii
HPY09_04305	ENOG4105F8V	Hydrolase, tatD family
HPY09_04310	ENOG4105CI1	PTS System
HPY09_04320	ENOG4105C8J	)-transporter
HPY09_04340	ENOG4105CA9	Pyruvate kinase
HPY09_04345	ENOG4105DAG	ROK family
HPY09_04365	ENOG4105DHI	Methyltransferase
HPY09_04375	ENOG4105DSB	aldose 1-epimerase
HPY09_04380	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY09_04385	ENOG4105E0X	reductase
HPY09_04395	ENOG4105VUT	cytoplasmic protein
HPY09_04400	ENOG4105HDK	L-asparaginase
HPY09_04405	ENOG4105D07	Signal peptide peptidase, SppA
HPY09_04410	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY09_04415	ENOG4105CIY	formyltetrahydrofolate deformylase
HPY09_04425	ENOG4105DVT	helicase
HPY09_04430	ENOG41072GX	Peptidase M22 Glycoprotease
HPY09_04445	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY09_04450	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY09_04455	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HPY09_04475	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY09_04480	ENOG4105DK2	UPF0207 protein
HPY09_04485	ENOG4105CHM	Aminotransferase
HPY09_04490	ENOG4105E4F	Isochorismate synthase
HPY09_04495	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPY09_04500	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HPY09_04505	ENOG4108IPT	Naphthoate synthase
HPY09_04515	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY09_04520	ENOG4105DKK	Benzoate
HPY09_04525	ENOG4107S74	Lysophospholipid transporter LplT
HPY09_04550	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HPY09_04555	ENOG4107QMS	site-determining protein
HPY09_04560	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HPY09_04565	ENOG4105VNG	YcgL domain-containing protein
HPY09_04570	ENOG4105CVE	Lytic murein transglycosylase
HPY09_04575	ENOG4105JQN	Transcriptional regulator
HPY09_04580	ENOG4105D9N	nucleoside
HPY09_04585	ENOG4105CUW	cytochrome C-TYPE protein
HPY09_04590	ENOG4107QY8	reductase
HPY09_04600	ENOG4105JQN	Transcriptional regulator
HPY09_04620	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HPY09_04655	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPY09_04665	ENOG4105BZU	Histidine kinase
HPY09_04675	ENOG4105CNG	UPF0061 protein
HPY09_04680	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPY09_04685	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HPY09_04690	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY09_04695	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_04710	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPY09_04715	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPY09_04720	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPY09_04725	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HPY09_04730	ENOG4105K70	DNA-binding protein
HPY09_04735	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HPY09_04740	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HPY09_04745	ENOG4105CAT	Cytidine monophosphate kinase
HPY09_04750	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPY09_04755	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY09_04760	ENOG4105Q4A	inner membrane protein yciS
HPY09_04765	ENOG4105CFV	Tetratricopeptide repeat protein
HPY09_04775	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HPY09_04785	ENOG4107R11	Transcriptional regulator
HPY09_04795	ENOG4105DCF	alanine dehydrogenase
HPY09_04800	ENOG4105EW9	transcriptional regulator AsnC family
HPY09_04805	ENOG4105CNU	cell division protein FtsK
HPY09_04810	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HPY09_04815	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY09_04820	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HPY09_04830	ENOG4108NVR	Methyl-accepting chemotaxis
HPY09_04835	ENOG4105K59	histidine triad (HIT) protein
HPY09_04860	ENOG4105D0Y	UPF0227 protein
HPY09_04865	ENOG4105CEP	NADH dehydrogenase
HPY09_04880	ENOG4106M3D	hemolysin
HPY09_04890	ENOG4108JA2	transcriptioN-repair coupling factor
HPY09_04900	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY09_04905	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY09_04910	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY09_04920	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HPY09_04925	ENOG4105BZ1	(ABC) transporter
HPY09_04930	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HPY09_04935	ENOG4105W49	UPF0434 protein
HPY09_04940	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY09_04945	ENOG4105ED1	spovr family
HPY09_04950	ENOG4106AKX	UPF0229 protein
HPY09_04955	ENOG4105CYN	Serine protein kinase
HPY09_04960	ENOG4105VNT	transposase (IS4 family) protein
HPY09_04965	ENOG4105XWI	UPF0304 protein
HPY09_04975	ENOG4105F1A	Pyruvate formate-lyase
HPY09_04980	ENOG4108N3W	hemolysin secretion protein
HPY09_04990	ENOG4105C6N	Formate acetyltransferase
HPY09_05000	ENOG4108JEH	abc transporter atp-binding protein
HPY09_05005	ENOG4105E89	ABC transporter
HPY09_05010	ENOG4105DSP	amino acid AbC transporter
HPY09_05015	ENOG4106YG3	ABC transporter
HPY09_05020	ENOG4105CGK	Exodeoxyribonuclease III
HPY09_05025	ENOG4106428	Protein of unknown function (DUF2496)
HPY09_05030	ENOG4108URS	primosomal replication protein n''
HPY09_05035	ENOG4105EJ9	Membrane
HPY09_05040	ENOG4105DVT	helicase
HPY09_05055	ENOG4105K5B	UPF0225 protein
HPY09_05060	ENOG4105D58	Diguanylate phosphodiesterase
HPY09_05065	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HPY09_05070	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY09_05075	ENOG4105C8N	cysteinyl-tRNA synthetase
HPY09_05080	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPY09_05085	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPY09_05095	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY09_05100	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY09_05110	ENOG4105KJB	cyd operon protein YbgE
HPY09_05115	ENOG4107YD3	Thioesterase
HPY09_05120	ENOG4105E02	MotA TolQ exbB proton channel
HPY09_05125	ENOG4105M8F	Biopolymer transport protein exbD tolR
HPY09_05135	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HPY09_05140	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HPY09_05150	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HPY09_05160	ENOG4105BZU	Histidine kinase
HPY09_05165	ENOG4108RNS	Exports L-alanine (By similarity)
HPY09_05170	ENOG4105EIP	mannose-6-phosphate isomerase
HPY09_05175	ENOG4105DM4	PTS System
HPY09_05180	ENOG4106R3P	AraC family transcriptional regulator
HPY09_05190	ENOG4108YRF	PTS System
HPY09_05195	ENOG4105DM4	PTS System
HPY09_05200	ENOG4105DM4	PTS System
HPY09_05210	ENOG4105C26	Dehydrogenase
HPY09_05215	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HPY09_05220	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY09_05230	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY09_05315	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPY09_05325	ENOG4105KT5	UmuD protein
HPY09_05365	ENOG4105MRD	Phage derived protein Gp49-like (DUF891)
HPY09_05410	ENOG4105T95	Thiol disulfide interChange protein
HPY09_05470	ENOG4105F88	accessory colonization factor AcfD
HPY09_05500	ENOG4105VT2	5-hydroxyisourate hydrolase
HPY09_05515	ENOG4107VGF	ig domain protein group 2 domain protein
HPY09_05520	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY09_05540	ENOG4105GRU	toxin co-regulated pilus biosynthesis outer membrane protein C
HPY09_05565	ENOG4108VEY	type ii secretion system
HPY09_05605	ENOG4108MA4	Peptidase M66
HPY09_05630	ENOG4108M3R	transcriptional activator CadC
HPY09_05635	ENOG4105BZS	acriflavin resistance protein
HPY09_05680	ENOG4108UUM	single-stranded DNA-binding protein
HPY09_05700	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
HPY09_05725	ENOG4108YGG	dna repair protein
HPY09_05765	ENOG410679B	prophage CP4-57 regulatory protein alpA
HPY09_05770	ENOG4105DFP	Integrase
HPY09_05785	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HPY09_05795	ENOG4105DY2	Paraquat-inducible protein b
HPY09_05800	ENOG4105F1S	paraquat-inducible protein a
HPY09_05825	ENOG4108R86	Transcriptional regulator
HPY09_05830	ENOG4105C26	Dehydrogenase
HPY09_05835	ENOG4105MTM	Protein of unknown function (DUF1496)
HPY09_05845	ENOG41067SE	Tetr family transcriptional regulator
HPY09_05850	ENOG4107QPN	acyl-Coa dehydrogenase
HPY09_05860	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPY09_05865	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HPY09_05870	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HPY09_05880	ENOG4105RKX	Protein of unknown function (DUF2498)
HPY09_05885	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY09_05890	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY09_05895	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPY09_05915	ENOG4105HP8	regulator of competence-specific genes
HPY09_05920	ENOG4105ETE	Transcriptional regulator (LacI family
HPY09_05930	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HPY09_05935	ENOG4107S90	membrAne
HPY09_05940	ENOG4106371	Methyltransferase
HPY09_05945	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HPY09_05950	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HPY09_05960	ENOG4105EW9	transcriptional regulator AsnC family
HPY09_05965	ENOG4108VP3	Lysine exporter protein (LysE YggA)
HPY09_05970	ENOG4105CCT	upf0313 protein
HPY09_05995	ENOG4105DZ2	Transcriptional regulator
HPY09_06000	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HPY09_06010	ENOG4105K9H	YciI-like protein
HPY09_06015	ENOG4105NAU	thioesterase Superfamily protein
HPY09_06030	ENOG4105GFG	DUF218 domain
HPY09_06035	ENOG4107SRH	Nad-dependent epimerase dehydratase
HPY09_06045	ENOG4105TMB	Formate nitrite transporter
HPY09_06060	ENOG4107QY8	reductase
HPY09_06080	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HPY09_06100	ENOG4108JQ2	peptide transport system atp-binding protein
HPY09_06105	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HPY09_06110	ENOG4108EU3	peptide transport system, permease
HPY09_06115	ENOG4108I5W	peptide transport system, permease protein
HPY09_06120	ENOG4108J59	Extracellular solute-binding protein, family 5
HPY09_06125	ENOG4105E51	psp operon transcriptional activator
HPY09_06130	ENOG41087YS	Phage shock protein A
HPY09_06145	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPY09_06160	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HPY09_06165	ENOG4105C28	cystathionine
HPY09_06175	ENOG4105C8J	)-transporter
HPY09_06180	ENOG4108W1A	pseudouridine synthase
HPY09_06185	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HPY09_06190	ENOG4108VGW	abc transporter atp-binding protein
HPY09_06195	ENOG4105CXZ	ABC transporter, permease
HPY09_06200	ENOG4105VNH	ABC transporter solute-binding protein
HPY09_06210	ENOG4105XZD	Fe-S protein
HPY09_06220	ENOG4105C44	Serine transporter
HPY09_06230	ENOG4105CJW	magnesium transporter
HPY09_06235	ENOG4105BZU	Histidine kinase
HPY09_06240	ENOG4105BZU	Histidine kinase
HPY09_06250	ENOG4105KXC	Collagenase
HPY09_06285	ENOG4108N3W	hemolysin secretion protein
HPY09_06300	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPY09_06305	ENOG4105BZU	Histidine kinase
HPY09_06320	ENOG4105CFI	type iii restriction protein res subunit
HPY09_06325	ENOG4105I08	Pseudouridine synthase
HPY09_06330	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY09_06340	ENOG4105CGD	Nad-dependent epimerase dehydratase
HPY09_06345	ENOG4105UQX	Mate efflux family protein
HPY09_06350	ENOG4108I0Y	(ABC) transporter
HPY09_06365	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY09_06375	ENOG4105E3Q	saccharopine dehydrogenase
HPY09_06380	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HPY09_06385	ENOG4105CDV	Ompa motb domain protein
HPY09_06390	ENOG4105DFG	type I secretion outer membrane protein
HPY09_06460	ENOG4105F04	LysR family Transcriptional regulator
HPY09_06470	ENOG4108VKG	metal-dependent hydrolase
HPY09_06475	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HPY09_06485	ENOG41090FY	type IV pilus biogenesis stability protein PilW
HPY09_06490	ENOG4105CVG	Homoserine O-transsuccinylase
HPY09_06510	ENOG4107V40	secretion protein, HlyD family
HPY09_06525	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY09_06530	ENOG4106YYS	transcriptional regulatory protein
HPY09_06540	ENOG4107R88	Chemotaxis protein (CheV)
HPY09_06590	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPY09_06595	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPY09_06600	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPY09_06610	ENOG4105C7K	acetolactate synthase
HPY09_06615	ENOG4107FQX	Alpha-acetolactate decarboxylase
HPY09_06625	ENOG4105F88	accessory colonization factor AcfD
HPY09_06635	ENOG4105CH6	catalase
HPY09_06645	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY09_06655	ENOG4108TWJ	NADH dehydrogenase subunit 5
HPY09_06660	ENOG4105DUM	transcriptional regulator, lysR family
HPY09_06680	ENOG4105V0I	UPF0267 protein
HPY09_06695	ENOG4105C9Q	fumarate hydratase class II
HPY09_06705	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY09_06710	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY09_06715	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY09_06720	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY09_06725	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY09_06735	ENOG4107QZV	Type I secretion membrane fusion protein
HPY09_06760	ENOG4108M8W	Monooxygenase
HPY09_06765	ENOG4108XDE	Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis
HPY09_06775	ENOG4105E09	nadh pyrophosphatase
HPY09_06780	ENOG4106MXH	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY09_06795	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY09_06805	ENOG4105CS2	ec 3.2.1.21
HPY09_06810	ENOG4105DDV	Transcriptional regulator (LacI family
HPY09_06815	ENOG4105M4H	endoribonuclease L-psp
HPY09_06820	ENOG4105XEP	YhcH YjgK YiaL family protein
HPY09_06825	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HPY09_06830	ENOG4105E98	transcriptional regulator DeoR family
HPY09_06835	ENOG4108IJ9	(ABC) transporter
HPY09_06840	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HPY09_06870	ENOG4109015	Biopolymer transport protein exbD tolR
HPY09_06875	ENOG41067XB	TonB family
HPY09_06895	ENOG4107QI1	Mate efflux family protein
HPY09_06915	ENOG4107TT5	NLP P60 protein
HPY09_06920	ENOG4108N3W	hemolysin secretion protein
HPY09_06930	ENOG4106IUH	DTW domain containing protein
HPY09_06935	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HPY09_06950	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY09_06955	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HPY09_06960	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY09_06965	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HPY09_06975	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_06980	ENOG4105BZU	Histidine kinase
HPY09_06985	ENOG4105C5H	ABC transporter
HPY09_06990	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPY09_07010	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY09_07020	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY09_07025	ENOG4105QAX	Iron-sulfur
HPY09_07040	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HPY09_07045	ENOG4108VPT	UPF0234 protein
HPY09_07050	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY09_07065	ENOG4105QNR	S1 RNA binding domain protein
HPY09_07075	ENOG4105DY2	Paraquat-inducible protein b
HPY09_07080	ENOG4105H2K	paraquat-inducible protein a
HPY09_07085	ENOG4105BZ1	(ABC) transporter
HPY09_07090	ENOG4108ZGC	gaf domain protein
HPY09_07095	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HPY09_07100	ENOG4105CN1	protease
HPY09_07110	ENOG4105CD8	aminopeptidase N
HPY09_07120	ENOG4105C7I	Dehydrogenase
HPY09_07125	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPY09_07130	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HPY09_07135	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HPY09_07145	ENOG4105C5H	ABC transporter
HPY09_07160	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HPY09_07165	ENOG4105DAN	ATP-dependent protease
HPY09_07170	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
HPY09_07270	ENOG4105EUK	rtx toxin RtxA
HPY09_07275	ENOG4108RC6	RTX toxin
HPY09_07300	ENOG4105BZU	Histidine kinase
HPY09_07315	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HPY09_07330	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HPY09_07340	ENOG4105C59	p-type ATPase
HPY09_07355	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HPY09_07360	ENOG4105Q9Y	Universal stress protein
HPY09_07365	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HPY09_07385	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY09_07395	ENOG4105D38	putrescine abc transporter
HPY09_07400	ENOG4108HM4	ABC transporter
HPY09_07405	ENOG4107RUE	extracellular solute-binding protein family 1
HPY09_07420	ENOG4105BZG	amino acid carrier protein
HPY09_07425	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY09_07455	ENOG4105CS6	Rhs element vgr protein
HPY09_07460	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY09_07465	ENOG4105CTD	carboxy-peptidase
HPY09_07485	ENOG4105C1J	atp-dependent rna helicase
HPY09_07495	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY09_07500	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY09_07505	ENOG4105EJC	lysr family transcriptional regulator
HPY09_07515	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HPY09_07520	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HPY09_07525	ENOG4105R8A	Heat shock protein
HPY09_07535	ENOG4105CQ7	ATP-dependent helicase
HPY09_07565	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY09_07570	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY09_07575	ENOG4105BZU	Histidine kinase
HPY09_07585	ENOG4105BZU	Histidine kinase
HPY09_07605	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HPY09_07610	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HPY09_07615	ENOG410667J	hydrolase
HPY09_07625	ENOG4107QXX	ABC transporter
HPY09_07630	ENOG4105EZ7	amino acid ABC transporter
HPY09_07635	ENOG4105DRP	amino acid AbC transporter
HPY09_07640	ENOG4105CDA	abc transporter atp-binding protein
HPY09_07645	ENOG4108MN8	Membrane
HPY09_07650	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HPY09_07655	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HPY09_07660	ENOG4105DR4	Methyltransferase
HPY09_07665	ENOG4106TD9	Diguanylate cyclase
HPY09_07675	ENOG4105BZU	Histidine kinase
HPY09_07680	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY09_07685	ENOG4108RXX	maleylacetoacetate isomerase
HPY09_07695	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HPY09_07700	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPY09_07705	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY09_07720	ENOG4105VNT	transposase (IS4 family) protein
HPY09_07725	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY09_07730	ENOG4105C7F	AcnD-accessory protein PrpF
HPY09_07735	ENOG4108I0Z	Aconitate hydratase
HPY09_07740	ENOG4105BZN	citrate synthase
HPY09_07745	ENOG4105CR4	methylisocitrate lyase
HPY09_07770	ENOG4108PTX	LysR family Transcriptional regulator
HPY09_07775	ENOG4105D05	Receptor
HPY09_07815	ENOG4107SDZ	Galactoside transport system permease protein mglC
HPY09_07820	ENOG4105C2J	ABC transporter
HPY09_07845	ENOG4107EXC	regulatoR
HPY09_07850	ENOG4105GR3	Histidine kinase
HPY09_07855	ENOG4105RW8	MltA-interacting MipA family protein
HPY09_07860	ENOG4108MJ5	VirK protein
HPY09_07865	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_07870	ENOG4105BZU	Histidine kinase
HPY09_07875	ENOG4105C8P	)-transporter
HPY09_07880	ENOG4108NVR	Methyl-accepting chemotaxis
HPY09_07885	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY09_07900	ENOG4105D9U	N-acetyltransferase
HPY09_07905	ENOG4108JU8	Transcriptional regulator
HPY09_07915	ENOG4105CM6	amino acid regulated cytosolic protein
HPY09_07930	ENOG4105CRQ	synthase (Component I)
HPY09_07935	ENOG4105P8F	nudix hydrolase
HPY09_07940	ENOG4105C44	Serine transporter
HPY09_07945	ENOG4105EJQ	L-serine dehydratase
HPY09_07950	ENOG4105VNT	transposase (IS4 family) protein
HPY09_07955	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HPY09_07965	ENOG4108N3W	hemolysin secretion protein
HPY09_07970	ENOG4105C5S	asparaginyl-tRNA synthetase
HPY09_07980	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY09_07985	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY09_08000	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_08005	ENOG4105DJ9	glucan biosynthesis protein
HPY09_08010	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HPY09_08015	ENOG4105C94	Transporter
HPY09_08020	ENOG41067TZ	transcriptional regulator, MarR family
HPY09_08035	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY09_08045	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY09_08060	ENOG4105C5X	domain protein
HPY09_08065	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HPY09_08100	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HPY09_08110	ENOG4105S8Q	sugar efflux transporter
HPY09_08120	ENOG4105C72	UPF0176 protein
HPY09_08125	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY09_08130	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPY09_08135	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY09_08140	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY09_08145	ENOG4107QK7	reductase
HPY09_08170	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_08185	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HPY09_08190	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HPY09_08205	ENOG4108YZT	Adenosylcobinamide kinase
HPY09_08210	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HPY09_08215	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HPY09_08220	ENOG4105E0X	reductase
HPY09_08225	ENOG4108ETY	sodium dicarboxylate symporter
HPY09_08230	ENOG4105CJB	Exodeoxyribonuclease I
HPY09_08235	ENOG4105VAW	lrga family
HPY09_08240	ENOG41067MG	lrgb family
HPY09_08260	ENOG4108RS6	transposase
HPY09_08275	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY09_08280	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HPY09_08285	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPY09_08325	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPY09_08330	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY09_08335	ENOG4105CQ2	DNA polymerase
HPY09_08340	ENOG4105BZU	Histidine kinase
HPY09_08350	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY09_08355	ENOG4108W5H	UPF0263 protein
HPY09_08365	ENOG4105CZE	histidine utilization repressor
HPY09_08370	ENOG4105CI2	imidazolone-5-propionate hydrolase
HPY09_08375	ENOG41088SP	formiminoglutamate hydrolase
HPY09_08380	ENOG4105CGP	Urocanate hydratase
HPY09_08385	ENOG4105C84	Histidine ammonia-lyase
HPY09_08405	ENOG4105CQB	FAD linked oxidase domain protein
HPY09_08420	ENOG4108ZG0	Ompa motb domain protein
HPY09_08440	ENOG4105C8V	SAICAR synthetase
HPY09_08450	ENOG4107R1I	NAD-dependent malic enzyme
HPY09_08460	ENOG4107GZ4	SanA protein
HPY09_08465	ENOG4105BZU	Histidine kinase
HPY09_08470	ENOG4105C9B	Cysteine desulfurase
HPY09_08480	ENOG4105C3M	thioredoxin reductase
HPY09_08485	ENOG4108JJ9	ABC, transporter
HPY09_08490	ENOG4108JJ8	(ABC) transporter
HPY09_08495	ENOG4105FE9	pseudouridine synthase
HPY09_08500	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPY09_08505	ENOG4105DB7	PHP domain protein
HPY09_08515	ENOG4105CRQ	synthase (Component I)
HPY09_08520	ENOG4105DDQ	anthranilate synthase
HPY09_08525	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPY09_08530	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPY09_08535	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPY09_08540	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPY09_08545	ENOG4105CK2	sodium dicarboxylate symporter
HPY09_08550	ENOG4107104	thymidine kinase
HPY09_08555	ENOG4105C9M	aspartyl-trna synthetase
HPY09_08560	ENOG41081XQ	Conserved Protein
HPY09_08565	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HPY09_08570	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HPY09_08575	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY09_08590	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPY09_08600	ENOG4105CUX	Signal transduction histidine kinase
HPY09_08625	ENOG4105DWU	Membrane
HPY09_08635	ENOG4105DY8	decarboxylase
HPY09_08640	ENOG4106KNT	transcriptional regulator
HPY09_08645	ENOG4105C0A	alcohol dehydrogenase
HPY09_08650	ENOG41090BQ	Glutaredoxin
HPY09_08655	ENOG4105D0C	transport protein
HPY09_08660	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY09_08665	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPY09_08670	ENOG4105VEQ	Cold shock protein
HPY09_08680	ENOG4108R99	pseudouridine synthase
HPY09_08685	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HPY09_08690	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPY09_08695	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY09_08700	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HPY09_08705	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPY09_08710	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPY09_08715	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPY09_08720	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPY09_08725	ENOG4107S6Z	Na H antiporter
HPY09_08735	ENOG4107RE1	Inosine-guanosine kinase
HPY09_08740	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPY09_08745	ENOG41075W9	High frequency lysogenization protein HflD homolog
HPY09_08750	ENOG4107QTF	adenylosuccinate lyase
HPY09_08760	ENOG4105RHG	
HPY09_08770	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HPY09_08795	ENOG4105D0M	Protease HtpX homolog
HPY09_08805	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HPY09_08810	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HPY09_08815	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY09_08820	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HPY09_08825	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HPY09_08830	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPY09_08835	ENOG4105D1H	recombination factor protein RarA
HPY09_08845	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY09_08850	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HPY09_08855	ENOG4105BZU	Histidine kinase
HPY09_08860	ENOG4108JJB	ABC transporter
HPY09_08865	ENOG4105C7J	ABC transporter, permease
HPY09_08875	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY09_08880	ENOG4105PQ6	UPF0208 membrane protein
HPY09_08885	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY09_08890	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HPY09_08895	ENOG4105CHF	Glutathione S-transferase
HPY09_08900	ENOG4108JQ7	(ABC) transporter
HPY09_08905	ENOG4105C3U	ABC transporter
HPY09_08910	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY09_08915	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY09_08920	ENOG4107QSI	ABC, transporter
HPY09_08935	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_08940	ENOG4105BZU	Histidine kinase
HPY09_08945	ENOG4105BZU	Histidine kinase
HPY09_08950	ENOG4105BZU	Histidine kinase
HPY09_08960	ENOG4107YTP	response regulator receiver protein
HPY09_08975	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY09_08990	ENOG4108RS6	transposase
HPY09_09000	ENOG4108V1U	phospholipid-binding protein
HPY09_09025	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY09_09030	ENOG41082YX	Transcriptional regulator, arsr family
HPY09_09040	ENOG4105BZU	Histidine kinase
HPY09_09060	ENOG4105C29	acyl-CoA thioesterase
HPY09_09065	ENOG4108XM1	transcriptional regulator AsnC family
HPY09_09075	ENOG4105ERU	peptidase
HPY09_09080	ENOG4105UBK	short-chain dehydrogenase reductase
HPY09_09090	ENOG4108ZZ3	UPF0260 protein
HPY09_09095	ENOG4105KRS	Proteinase inhibitor
HPY09_09105	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HPY09_09110	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HPY09_09115	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPY09_09120	ENOG4105WD1	Membrane
HPY09_09125	ENOG4105I93	response regulator
HPY09_09130	ENOG4105EJC	lysr family transcriptional regulator
HPY09_09135	ENOG41069NU	Nitroreductase
HPY09_09140	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY09_09145	ENOG4105CHU	acetyl-coa acetyltransferase
HPY09_09160	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY09_09165	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY09_09175	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HPY09_09180	ENOG4108GAE	asmA family
HPY09_09185	ENOG4105DBI	uridine monophosphokinase
HPY09_09190	ENOG4105D1F	ATP-binding protein
HPY09_09195	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPY09_09205	ENOG4108I5U	Uridine phosphorylase
HPY09_09220	ENOG4105BZU	Histidine kinase
HPY09_09225	ENOG4108ZAF	Molybdopterin
HPY09_09230	ENOG4105M00	molybdopterin converting factor, subunit 1
HPY09_09235	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY09_09240	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HPY09_09245	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY09_09250	ENOG4105CHW	UPF0052 protein
HPY09_09260	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_09265	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HPY09_09280	ENOG4108R3D	Electron transport complex
HPY09_09300	ENOG4105DZB	Electron transport complex
HPY09_09305	ENOG4105CSM	endonuclease III
HPY09_09310	ENOG4108UYE	Lactoylglutathione lyase
HPY09_09315	ENOG4106WH9	Protein of unknown function (DUF2753)
HPY09_09320	ENOG4105EIY	sodium-type flagellar protein motY
HPY09_09325	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
HPY09_09330	ENOG4105D3Y	Na H antiporter
HPY09_09335	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HPY09_09340	ENOG4105E96	Colicin v production protein
HPY09_09345	ENOG4108S3P	Sporulation domain protein
HPY09_09350	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPY09_09355	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HPY09_09360	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPY09_09375	ENOG4105CI1	PTS System
HPY09_09380	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY09_09385	ENOG4105E2R	ROK family
HPY09_09390	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPY09_09400	ENOG4105MDZ	Transcriptional activator rfaH
HPY09_09405	ENOG4105DUX	Transporter
HPY09_09410	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPY09_09415	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPY09_09420	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HPY09_09425	ENOG4108TU9	TRANSCRIPTIONal
HPY09_09440	ENOG4108RE9	Phosphodiesterase
HPY09_09445	ENOG4105ECP	epimerase
HPY09_09450	ENOG4105E1F	short-chain dehydrogenase reductase
HPY09_09455	ENOG4107QR8	Thioredoxin
HPY09_09460	ENOG4107QX8	SPFH domain, Band 7 family protein
HPY09_09465	ENOG4105G5H	Membrane
HPY09_09470	ENOG4108Z6Z	Transcriptional regulator
HPY09_09480	ENOG41081QG	Porin Gram-negative type
HPY09_09485	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPY09_09490	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HPY09_09495	ENOG4105EXN	Sulfate transport protein CysZ
HPY09_09500	ENOG4105C6T	cysteine synthase
HPY09_09505	ENOG4105KZ7	phosphocarrier protein hpr
HPY09_09510	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPY09_09515	ENOG4105C5Y	PTS System
HPY09_09520	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY09_09525	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HPY09_09530	ENOG4105C9A	Phoh family
HPY09_09535	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HPY09_09540	ENOG4108JU5	Magnesium and cobalt efflux protein
HPY09_09545	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HPY09_09550	ENOG4107PAI	alpha helical protein
HPY09_09555	ENOG4105C8T	Leucyl-tRNA synthetase
HPY09_09560	ENOG4108U2H	Rare lipoprotein B
HPY09_09565	ENOG4105DJF	DNA polymerase III, delta' subunit
HPY09_09570	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HPY09_09575	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HPY09_09580	ENOG4105CJN	penicillin-binding protein
HPY09_09585	ENOG4105CNI	cell division protein FtsW
HPY09_09590	ENOG4105K6T	rare lipoprotein A
HPY09_09595	ENOG4105DZ1	carboxypeptidase
HPY09_09600	ENOG4108Z43	UPF0250 protein
HPY09_09605	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HPY09_09610	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPY09_09620	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY09_09640	ENOG4105D75	Capsular exopolysaccharide family
HPY09_09645	ENOG4105DAY	polysaccharide export protein
HPY09_09655	ENOG4105D3Q	Sugar transferase
HPY09_09670	ENOG4108MA4	Peptidase M66
HPY09_09685	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HPY09_09695	ENOG4105Q84	sucrose synthase
HPY09_09705	ENOG4105D7W	serine acetyltransferase
HPY09_09725	ENOG4108UW5	maltose o-acetyltransferase
HPY09_09735	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY09_09740	ENOG4107ZCW	Low molecular weight phosphotyrosine protein phosphatase
HPY09_09745	ENOG4105BZS	acriflavin resistance protein
HPY09_09775	ENOG4105CG3	alpha amylase, catalytic region
HPY09_09780	ENOG4105C5Y	PTS System
HPY09_09785	ENOG4105D4X	repressor
HPY09_09790	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HPY09_09795	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HPY09_09800	ENOG4108UMI	ABC transporter, permease
HPY09_09805	ENOG4105D01	(LipO)protein
HPY09_09810	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HPY09_09815	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HPY09_09820	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HPY09_09830	ENOG4105BZU	Histidine kinase
HPY09_09835	ENOG4105EWT	decarboxylase family
HPY09_09840	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HPY09_09845	ENOG4105M08	Membrane
HPY09_09850	ENOG4105ETT	transcriptional Regulator, LysR family
HPY09_09855	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HPY09_09860	ENOG4106VK6	Flagellar motor protein
HPY09_09865	ENOG4105E14	MotA TolQ exbB proton channel
HPY09_09875	ENOG4105CTB	Polyprenyl synthetase
HPY09_09880	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HPY09_09885	ENOG4105DR9	pseudouridine synthase
HPY09_09890	ENOG4105WP7	tRNA pseudouridine synthase C
HPY09_09905	ENOG4108428	Inherit from COG: -acetyltransferase
HPY09_09915	ENOG4108UPT	UPF0178 protein
HPY09_09920	ENOG4105CFC	Transporter
HPY09_09930	ENOG4105NRA	50s ribosomal protein l31 type b
HPY09_09935	ENOG4108R96	Methyltransferase, YaeB family
HPY09_09940	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPY09_09960	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPY09_09970	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPY09_09975	ENOG4108Z6B	deaminase
HPY09_09980	ENOG4105CFC	Transporter
HPY09_10010	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY09_10020	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY09_10025	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPY09_10030	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPY09_10035	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY09_10040	ENOG4105VDB	UPF0125 protein
HPY09_10045	ENOG4108Z1B	Cyclase dehydrase
HPY09_10050	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPY09_10145	ENOG4105DZ0	fad dependent oxidoreductase
HPY09_10150	ENOG4108Z4U	Ferredoxin
HPY09_10175	ENOG4105CHY	citrate lyase, alpha
HPY09_10180	ENOG4105CI0	Citrate lyase
HPY09_10190	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
HPY09_10195	ENOG4105D2K	citrate carrier protein
HPY09_10205	ENOG4107QSA	Oxaloacetate decarboxylase
HPY09_10210	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY09_10215	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY09_10220	ENOG4106YYS	transcriptional regulatory protein
HPY09_10245	ENOG4105BZG	amino acid carrier protein
HPY09_10250	ENOG4105EUZ	Beta-lactamase domain protein
HPY09_10255	ENOG41064T2	transcriptional regulator, lysR family
HPY09_10265	ENOG4105E0A	ABC, transporter
HPY09_10270	ENOG4105TVJ	transport system, permease
HPY09_10275	ENOG4105DQ5	transport system permease protein
HPY09_10280	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HPY09_10290	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HPY09_10295	ENOG4105E4F	Isochorismate synthase
HPY09_10300	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY09_10305	ENOG4105WQI	isochorismatase
HPY09_10310	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HPY09_10320	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HPY09_10330	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPY09_10335	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY09_10340	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPY09_10355	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPY09_10360	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY09_10365	ENOG4105N21	Membrane
HPY09_10370	ENOG4105CUT	histidyl-tRNA synthetase
HPY09_10375	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPY09_10385	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HPY09_10390	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HPY09_10400	ENOG4105WVQ	Fe-S assembly protein IscX
HPY09_10405	ENOG4108ZIT	Ferredoxin, 2FE-2S
HPY09_10420	ENOG4108Z4V	iron-sulfur cluster assembly
HPY09_10425	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HPY09_10435	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HPY09_10440	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HPY09_10445	ENOG4105ECY	inositol monophosphatase
HPY09_10450	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY09_10455	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY09_10460	ENOG4105VIE	preprotein translocase, subunit YajC
HPY09_10470	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HPY09_10475	ENOG4105W87	Cbs domain
HPY09_10480	ENOG4108I9X	Isocitrate lyase
HPY09_10485	ENOG4107QP3	malate synthase g
HPY09_10490	ENOG4105C5Q	Transcriptional regulator
HPY09_10495	ENOG4105D3R	alkyl hydroperoxide reductase
HPY09_10500	ENOG4106N3A	copper homeostasis protein cutc
HPY09_10505	ENOG4105CSR	polyphosphate kinase 2
HPY09_10515	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY09_10520	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY09_10525	ENOG4105C8U	phosphate abc transporter
HPY09_10530	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HPY09_10535	ENOG4105C9X	ppx gppa phosphatase
HPY09_10540	ENOG4105DJH	phosphate
HPY09_10545	ENOG4105BZU	Histidine kinase
HPY09_10550	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY09_10560	ENOG4105CFP	Peptidase U32
HPY09_10565	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HPY09_10610	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY09_10615	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPY09_10620	ENOG4105C34	Pseudouridine synthase
HPY09_10625	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_10630	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HPY09_10640	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
HPY09_10645	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY09_10655	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
HPY09_10660	ENOG4107SC1	transglycosylase
HPY09_10665	ENOG4105C5H	ABC transporter
HPY09_10680	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY09_10685	ENOG4108HRK	Histidine kinase
HPY09_10690	ENOG4108NEV	two component transcriptional regulator, LytTR family
HPY09_10700	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HPY09_10705	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY09_10725	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPY09_10730	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HPY09_10735	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HPY09_10745	ENOG4105DTN	riboflavin biosynthesis protein ribF
HPY09_10750	ENOG4105CJR	Integral membrane protein (MviN
HPY09_10755	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HPY09_10760	ENOG41080HT	Transcriptional regulator, arsr family
HPY09_10765	ENOG41063Z6	transcriptional regulator, lysR family
HPY09_10775	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HPY09_10780	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPY09_10785	ENOG4105HF0	Membrane
HPY09_10790	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HPY09_10795	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPY09_10800	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
HPY09_10805	ENOG4105CPC	Aldo Keto reductase
HPY09_10815	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_10820	ENOG4105CRK	lysyL-tRNA synthetase
HPY09_10830	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPY09_10840	ENOG4105C1J	atp-dependent rna helicase
HPY09_10850	ENOG4105BZU	Histidine kinase
HPY09_10865	ENOG4108YYD	acetyltransferase
HPY09_10875	ENOG4105BZU	Histidine kinase
HPY09_10910	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HPY09_10920	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HPY09_10925	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPY09_10930	ENOG4105CHV	Transcription elongation factor NusA
HPY09_10935	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HPY09_10950	ENOG4105NTZ	Preprotein translocase subunit SecG
HPY09_10960	ENOG4105EEI	dihydropteroate synthase
HPY09_10965	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPY09_10970	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HPY09_10975	ENOG4105HBR	Rna-binding protein
HPY09_10980	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPY09_10985	ENOG4105FCK	Membrane
HPY09_10990	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HPY09_10995	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY09_11000	ENOG4105DR5	peptidase
HPY09_11015	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HPY09_11020	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPY09_11025	ENOG4105IPI	Membrane
HPY09_11030	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY09_11040	ENOG4107QRA	Extracellular solute-binding protein, family 5
HPY09_11050	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY09_11055	ENOG4105C3U	ABC transporter
HPY09_11060	ENOG4108JQ7	(ABC) transporter
HPY09_11070	ENOG4105RD7	BadF BadG BcrA BcrD
HPY09_11075	ENOG4105E2D	ec 3.2.1.52
HPY09_11080	ENOG4105E2V	Glycosyltransferase 36
HPY09_11090	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY09_11115	ENOG4105XTV	UPF0231 protein
HPY09_11120	ENOG4107QIJ	Aconitate hydratase 2
HPY09_11125	ENOG4105D78	K07001 NTE family protein
HPY09_11130	ENOG4105BZ4	penicillin-binding protein
HPY09_11135	ENOG4105CQ7	ATP-dependent helicase
HPY09_11145	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HPY09_11150	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPY09_11155	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HPY09_11160	ENOG4105DJ0	Poly(A) Polymerase
HPY09_11165	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY09_11170	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPY09_11175	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPY09_11180	ENOG4105E3A	(ABC) transporter
HPY09_11185	ENOG4105DA5	(ABC) transporter
HPY09_11190	ENOG4105CHH	sulfate transporter
HPY09_11195	ENOG41077A9	carbonic anhydrase
HPY09_11200	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPY09_11205	ENOG410630P	Transcriptional regulator
HPY09_11210	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HPY09_11215	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HPY09_11220	ENOG41082RQ	UPF0102 protein
HPY09_11225	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY09_11230	ENOG4105W4M	Transport-associated protein
HPY09_11235	ENOG4105KB2	stringent starvation protein b
HPY09_11240	ENOG4107MKT	Stringent starvation protein a
HPY09_11245	ENOG4105EIX	cytochrome c1
HPY09_11250	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY09_11255	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY09_11260	ENOG4108UJD	30S ribosomal protein S9
HPY09_11265	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPY09_11270	ENOG4105D6Z	AFG1 family ATPase
HPY09_11280	ENOG4105C0H	protease
HPY09_11285	ENOG4105C0H	protease
HPY09_11290	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HPY09_11295	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPY09_11300	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPY09_11305	ENOG4105K5M	30s ribosomal protein S16
HPY09_11310	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY09_11315	ENOG4106KVJ	cytochrome C assembly protein
HPY09_11320	ENOG4108JU6	CBS domain protein
HPY09_11325	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPY09_11330	ENOG4105D9M	gamma-glutamylcysteine synthetase
HPY09_11340	ENOG4105W39	Membrane
HPY09_11350	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY09_11355	ENOG4107QSA	Oxaloacetate decarboxylase
HPY09_11405	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HPY09_11415	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPY09_11425	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPY09_11435	ENOG4108IJ6	ABC transporter
HPY09_11440	ENOG4105ECW	sulfate abc transporter
HPY09_11445	ENOG4108I5D	sulfate abc transporter
HPY09_11450	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY09_11455	ENOG4105C6T	cysteine synthase
HPY09_11460	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HPY09_11465	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY09_11470	ENOG4108K5P	(LipO)protein
HPY09_11475	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HPY09_11480	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HPY09_11485	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HPY09_11490	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPY09_11495	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPY09_11505	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPY09_11510	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY09_11515	ENOG4107ZVW	dihydroneopterin aldolase
HPY09_11520	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HPY09_11530	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY09_11535	ENOG4105VCC	30S ribosomal protein S21
HPY09_11540	ENOG4105KTH	gatB Yqey
HPY09_11545	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPY09_11550	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY09_11565	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY09_11570	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HPY09_11575	ENOG410804X	Transcriptional regulator
HPY09_11580	ENOG4105CA9	Pyruvate kinase
HPY09_11585	ENOG4105MPN	Membrane
HPY09_11595	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HPY09_11600	ENOG4105D64	Mechanosensitive ion channel
HPY09_11610	ENOG4105BZA	Phosphoglycerate kinase
HPY09_11615	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY09_11620	ENOG4105D05	Receptor
HPY09_11625	ENOG4108R4R	Iron-regulated virulence regulatory protein
HPY09_11630	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY09_11635	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HPY09_11645	ENOG4105RWS	endonuclease I
HPY09_11655	ENOG4105D7Z	glutathione synthase
HPY09_11660	ENOG4108UJU	UPF0301 protein
HPY09_11665	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPY09_11670	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY09_11680	ENOG4105CZX	twitching motility protein
HPY09_11685	ENOG4105CZX	twitching motility protein
HPY09_11690	ENOG4105DFA	alanine racemase domain protein
HPY09_11695	ENOG4105II7	pyrroline-5-carboxylate reductase
HPY09_11700	ENOG4108VIA	integral membrane protein
HPY09_11705	ENOG4105VZ9	UPF0235 protein
HPY09_11715	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HPY09_11720	ENOG4105CSA	Coproporphyrinogen iii oxidase
HPY09_11725	ENOG4105CSV	Glutaminase
HPY09_11730	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HPY09_11735	ENOG4105CEN	a g-specific adenine glycosylase
HPY09_11740	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HPY09_11745	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HPY09_11800	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HPY09_11805	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HPY09_11810	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HPY09_11815	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HPY09_11820	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HPY09_11825	ENOG4105NWN	ApaG protein
HPY09_11830	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HPY09_11840	ENOG4107XM3	UPF0442 protein
HPY09_11845	ENOG4105DWK	Membrane
HPY09_11850	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY09_11855	ENOG4105K46	50S ribosomal protein l27
HPY09_11860	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPY09_11865	ENOG4105EAH	synthase
HPY09_11870	ENOG4105D5Q	Arginine ornithine antiporter
HPY09_11875	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HPY09_11880	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPY09_11885	ENOG4105H1G	trap transporter solute receptor taxi family
HPY09_11895	ENOG41081QV	Universal stress protein
HPY09_11915	ENOG4105CEU	Arginine dihydrolase
HPY09_11920	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HPY09_11930	ENOG4105QD6	exported protein
HPY09_11935	ENOG4105C03	ribonuclease
HPY09_11940	ENOG4108Z03	MAF-like protein
HPY09_11945	ENOG4105VQ7	Rod shape-determining protein MreD
HPY09_11950	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HPY09_11990	ENOG4105X0D	Fimbrial protein
HPY09_12000	ENOG4105D7Q	type ii secretion system
HPY09_12005	ENOG4107QHF	type ii secretion system protein e
HPY09_12040	ENOG41062P1	Diguanylate cyclase phosphodiesterase
HPY09_12045	ENOG4108UUM	single-stranded DNA-binding protein
HPY09_12050	ENOG41086KC	Transcriptional regulator
HPY09_12055	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HPY09_12060	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HPY09_12070	ENOG4105C5R	Aminotransferase
HPY09_12075	ENOG4105CFH	Aspartokinase
HPY09_12080	ENOG4105C3R	Methionine synthase
HPY09_12085	ENOG4105EEQ	Na H antiporter
HPY09_12120	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPY09_12130	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HPY09_12150	ENOG4105P4Z	Phage shock protein G
HPY09_12155	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY09_12160	ENOG4105MYN	Zinc uptake regulation protein
HPY09_12175	ENOG4107QP8	phosphohexose isomerase
HPY09_12180	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HPY09_12185	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY09_12190	ENOG4105CDU	Replicative dna helicase
HPY09_12200	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPY09_12205	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPY09_12210	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HPY09_12215	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPY09_12220	ENOG4108UQY	Iron-storage protein
HPY09_12225	ENOG4105W53	bacterioferritin-associated ferredoxin
HPY09_12230	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY09_12235	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY09_12240	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPY09_12255	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPY09_12260	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HPY09_12265	ENOG4105WWK	YheO domain protein
HPY09_12270	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY09_12280	ENOG41069P5	Protein slyX homolog
HPY09_12290	ENOG4105EPW	hflc protein
HPY09_12295	ENOG4107QJR	hflk protein
HPY09_12300	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPY09_12305	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HPY09_12310	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPY09_12315	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HPY09_12320	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HPY09_12325	ENOG4105K8N	protein family UPF0079, ATPase
HPY09_12330	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HPY09_12380	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPY09_12385	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPY09_12390	ENOG4105DJ4	phosphatidylserine decarboxylase
HPY09_12395	ENOG4105C8P	)-transporter
HPY09_12405	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPY09_12410	ENOG41063SB	peptidase
HPY09_12420	ENOG41062JF	Transcriptional regulator
HPY09_12425	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HPY09_12430	ENOG4105E09	nadh pyrophosphatase
HPY09_12435	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HPY09_12440	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY09_12445	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY09_12450	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HPY09_12455	ENOG4108VZM	50s ribosomal protein L10
HPY09_12465	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HPY09_12470	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPY09_12475	ENOG4105PM1	preprotein translocase subunit SecE
HPY09_12480	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY09_12505	ENOG4105CS9	pantothenic acid kinase
HPY09_12510	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPY09_12515	ENOG4105D4A	Cell wall formation (By similarity)
HPY09_12525	ENOG4105JIM	Phosphatidylserine synthase
HPY09_12595	ENOG4107QK7	reductase
HPY09_12605	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HPY09_12615	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HPY09_12625	ENOG4105C1J	atp-dependent rna helicase
HPY09_12630	ENOG4105C9X	ppx gppa phosphatase
HPY09_12635	ENOG4105BZU	Histidine kinase
HPY09_12640	ENOG4105D8G	Major Facilitator superfamily
HPY09_12660	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HPY09_12665	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HPY09_12670	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HPY09_12675	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY09_12680	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY09_12685	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HPY09_12690	ENOG4105DIQ	Transcriptional regulator
HPY09_12700	ENOG4105EWV	Sodium calcium exchanger membrane region
HPY09_12705	ENOG4105C01	Dihydroxy-acid dehydratase
HPY09_12710	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPY09_12715	ENOG4105C6Z	Gluconate
HPY09_12720	ENOG4108UHU	Aldolase
HPY09_12725	ENOG4105E0K	tonB-dependent siderophore receptor
HPY09_12740	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_12750	ENOG4105D5Q	Arginine ornithine antiporter
HPY09_12755	ENOG4108M3R	transcriptional activator CadC
HPY09_12760	ENOG4105W1Y	Transcriptional regulator
HPY09_12775	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPY09_12785	ENOG4105K70	DNA-binding protein
HPY09_12795	ENOG4105R2J	Conserved Protein
HPY09_12800	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HPY09_12805	ENOG4108RG0	uracil-dna glycosylase
HPY09_12810	ENOG4105CUY	Mechanosensitive ion channel
HPY09_12815	ENOG4105CY0	Metallo-Beta-Lactamase
HPY09_12820	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY09_12830	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY09_12850	ENOG4107V1M	polysaccharide export protein
HPY09_12865	ENOG41090SZ	ABC-2 type transporter
HPY09_12870	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY09_12890	ENOG4108MDC	(LipO)protein
HPY09_12900	ENOG4105E3R	(LipO)protein
HPY09_12915	ENOG4105D3Q	Sugar transferase
HPY09_12935	ENOG4105CKK	Glycosyl transferase, family 2
HPY09_12960	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY09_12970	ENOG4105C5E	polysaccharide biosynthesis protein
HPY09_12975	ENOG4108TMJ	glycosyl transferase
HPY09_13005	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HPY09_13010	ENOG4107T94	Endo-14-beta-xylanase
HPY09_13030	ENOG4105XA0	heptosyltransferase ii
HPY09_13035	ENOG4108ST3	glycosyltransferase
HPY09_13040	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HPY09_13065	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
HPY09_13070	ENOG4105DKP	glycosyl transferase, family 9
HPY09_13075	ENOG4106WTF	Glycosyl transferase, family 2
HPY09_13080	ENOG4105M5K	heptosyltransferase
HPY09_13085	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPY09_13090	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPY09_13100	ENOG4105W0E	50S ribosomal protein L33
HPY09_13105	ENOG4105KDC	50s ribosomal protein l28
HPY09_13110	ENOG4105W5Q	DNA repair protein (RadC
HPY09_13115	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_13120	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HPY09_13130	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HPY09_13135	ENOG4105D1S	lipid A biosynthesis
HPY09_13140	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HPY09_13145	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPY09_13150	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPY09_13155	ENOG4105DSJ	YicC domain protein
HPY09_13160	ENOG4108TEB	UPF0114 protein
HPY09_13165	ENOG4105FCK	Membrane
HPY09_13170	ENOG4105C5Y	PTS System
HPY09_13175	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY09_13180	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HPY09_13190	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPY09_13195	ENOG4105FR1	rard protein
HPY09_13200	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY09_13205	ENOG4108DMH	HTH_ARAC
HPY09_13210	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY09_13215	ENOG4105C4R	Atp-dependent dna helicase
HPY09_13220	ENOG4105DGW	oligopeptidase A
HPY09_13225	ENOG4105D6S	protein involved in catabolism of external DNA
HPY09_13230	ENOG4105DC8	reductase
HPY09_13240	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY09_13245	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY09_13250	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPY09_13290	ENOG4105MPD	Cytochrome
HPY09_13295	ENOG4105C4R	Atp-dependent dna helicase
HPY09_13300	ENOG4105Y7M	Transcriptional regulator, TetR family
HPY09_13305	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPY09_13310	ENOG4105BZS	acriflavin resistance protein
HPY09_13315	ENOG4105W0Z	cytoplasmic protein
HPY09_13320	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HPY09_13325	ENOG4105EMY	transcriptional regulator
HPY09_13395	ENOG4108RR8	protoporphyrinogen oxidase
HPY09_13400	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY09_13405	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPY09_13410	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY09_13415	ENOG4105CHU	acetyl-coa acetyltransferase
HPY09_13420	ENOG4105F52	Transcriptional regulator
HPY09_13425	ENOG4105CZQ	inner membrane transport protein YdhC
HPY09_13435	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPY09_13440	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPY09_13445	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPY09_13450	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPY09_13455	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY09_13460	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY09_13470	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPY09_13475	ENOG410684E	atp synthase
HPY09_13480	ENOG4105FA0	parb-like partition protein
HPY09_13485	ENOG4107QJE	Chromosome Partitioning Protein
HPY09_13490	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPY09_13495	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HPY09_13500	ENOG4105QTB	Flavodoxin
HPY09_13505	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HPY09_13510	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPY09_13520	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HPY09_13535	ENOG4105E5Q	amino acid AbC transporter
HPY09_13540	ENOG4105EAB	amino acid AbC transporter
HPY09_13545	ENOG4106RMF	ParB family
HPY09_13575	ENOG4105CDY	transcriptional regulatory protein
HPY09_13580	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPY09_13585	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_13590	ENOG4108YYI	Protein of unknown function (DUF2810)
HPY09_13595	ENOG41061ZR	Transcriptional regulator
HPY09_13600	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HPY09_13610	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPY09_13615	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY09_13620	ENOG4105CS6	Rhs element vgr protein
HPY09_13645	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY09_13655	ENOG4105C8P	)-transporter
HPY09_13660	ENOG4108Q67	UPF0319 protein
HPY09_13690	ENOG4105EYK	Phosphatidylglycerophosphatase B
HPY09_13700	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HPY09_13725	ENOG4105D6U	Sodium Glutamate Symporter
HPY09_13730	ENOG4105YE1	PilZ domain
HPY09_13745	ENOG4105EFX	secretion protein, HlyD family
HPY09_13750	ENOG4105KK7	inner membrane protein YiaW
HPY09_13755	ENOG4106TD9	Diguanylate cyclase
HPY09_13770	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY09_13775	ENOG4107SEY	Conserved Protein
HPY09_13785	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY09_13790	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HPY09_13800	ENOG4105C1J	atp-dependent rna helicase
HPY09_13805	ENOG4105CUG	Oligopeptidase b
HPY09_13835	ENOG4105CVA	phosphate
HPY09_13840	ENOG4105C8U	phosphate abc transporter
HPY09_13845	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY09_13850	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY09_13865	ENOG4105DWD	nucleoside recognition domain protein
HPY09_13870	ENOG4105CHH	sulfate transporter
HPY09_13880	ENOG4105DR5	peptidase
HPY09_13885	ENOG4105BZU	Histidine kinase
HPY09_13890	ENOG4105EQ2	LysR family Transcriptional regulator
HPY09_13895	ENOG4105E5M	Multidrug resistance protein D
HPY09_13900	ENOG4108Z4X	TRANSCRIPTIONal
HPY09_13915	ENOG4105CK2	sodium dicarboxylate symporter
HPY09_13965	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HPY09_13970	ENOG4105D9R	oxidoreductase
HPY09_13980	ENOG4105BZU	Histidine kinase
HPY09_13985	ENOG4107VXZ	Hydrolase
HPY09_13995	ENOG4105D3G	Pseudouridine synthase
HPY09_14055	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY09_14060	ENOG4108JUB	Transcriptional regulator
HPY09_14100	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HPY09_14105	ENOG4105C2J	ABC transporter
HPY09_14110	ENOG4105CNN	ABC, transporter
HPY09_14115	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPY09_14120	ENOG4108RVA	ribokinase
HPY09_14125	ENOG4105ETE	Transcriptional regulator (LacI family
HPY09_14130	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HPY09_14135	ENOG4108I5U	Uridine phosphorylase
HPY09_14155	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPY09_14160	ENOG4105CXY	transporter
HPY09_14175	ENOG4105CQZ	Histidine kinase
HPY09_14180	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY09_14195	ENOG4105D5U	fad dependent oxidoreductase
HPY09_14205	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPY09_14210	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY09_14215	ENOG4105KJM	monovalent cation h antiporter subunit g
HPY09_14225	ENOG4105SC1	monovalent cation H antiporter subunit E
HPY09_14230	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HPY09_14235	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HPY09_14240	ENOG4105D65	subunit l
HPY09_14250	ENOG4105Q9Y	Universal stress protein
HPY09_14255	ENOG4105CIC	tryptophan-specific transport protein
HPY09_14270	ENOG4105VRT	cytoplasmic protein
HPY09_14280	ENOG4105BZU	Histidine kinase
HPY09_14285	ENOG4105VEQ	Cold shock protein
HPY09_14300	ENOG4107QVM	von Willebrand factor, type A
HPY09_14320	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPY09_14325	ENOG41069D7	Methyl-accepting chemotaxis
HPY09_14340	ENOG4105D9N	nucleoside
HPY09_14345	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY09_14355	ENOG4108JUA	Transcriptional regulator
HPY09_14360	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY09_14365	ENOG4105VEQ	Cold shock protein
HPY09_14385	ENOG4108UNF	response regulator
HPY09_14395	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HPY09_14400	ENOG4105C5I	Dehydrogenase
HPY09_14420	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY09_14435	ENOG4108RS6	transposase
HPY09_14445	ENOG4105C1J	atp-dependent rna helicase
HPY09_14450	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY09_14455	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HPY09_14465	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY09_14475	ENOG4105BZU	Histidine kinase
HPY09_14485	ENOG4107S6Z	Na H antiporter
HPY09_14490	ENOG4105E5M	Multidrug resistance protein D
HPY09_14500	ENOG4105BZU	Histidine kinase
HPY09_14505	ENOG4105KUU	lipolytic protein G-D-S-L family
HPY09_14510	ENOG4106M3D	hemolysin
HPY09_14515	ENOG4108N3W	hemolysin secretion protein
HPY09_14520	ENOG4107IFA	Lipase (EC 3.1.1.3)
HPY09_14550	ENOG4105DHS	permease protein
HPY09_14555	ENOG4105CM4	permease protein
HPY09_14560	ENOG4108IPW	abc transporter atp-binding protein
HPY09_14580	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY09_14585	ENOG41082YX	Transcriptional regulator, arsr family
HPY09_14590	ENOG4105D6J	arsenicaL-resistance protein
HPY09_14610	ENOG4105CR8	Transcriptional regulator
HPY09_14625	ENOG4105ETX	regulatoR
HPY09_14655	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HPY09_14665	ENOG410667J	hydrolase
HPY09_14710	ENOG4105CHJ	isochorismatase hydrolase
HPY09_14715	ENOG4105C2I	pirin domain protein
HPY09_14720	ENOG4105EGI	Transcriptional regulator
HPY09_14745	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY09_14750	ENOG4105BZU	Histidine kinase
HPY09_14770	ENOG4107QVI	Methyltransferase, type 11
HPY09_14785	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
HPY09_14790	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_14800	ENOG4105DZ1	carboxypeptidase
HPY09_14820	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY09_14825	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HPY09_14830	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY09_14850	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPY09_14855	ENOG41082NX	50s ribosomal protein l35
HPY09_14860	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPY09_14940	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY09_14975	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HPY09_15035	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY09_15070	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY09_15100	ENOG4108S58	Phenazine biosynthesis protein PhzF
HPY09_15395	ENOG4108EF6	Proline imino-peptidase
HPY09_15400	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY09_15495	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY09_15545	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY09_15555	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY09_15605	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY09_15665	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HPY09_15875	ENOG4105VXN	addiction module toxin, RelE StbE family
HPY09_15935	ENOG4105EST	Metal Dependent Phosphohydrolase
HPY09_15960	ENOG4105KD7	acetyltransferase
HPY09_15975	ENOG41080ET	plasmid maintenance system killer protein
HPY09_15980	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
HPY09_16040	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY09_16075	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY09_16160	ENOG4105HHM	rdd domain containing protein
HPY09_16610	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY09_16710	ENOG4108RS6	transposase
HPY09_16715	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY09_16720	ENOG4105CDV	Ompa motb domain protein
HPY09_16725	ENOG4108NVR	Methyl-accepting chemotaxis
HPY09_16730	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPY09_16735	ENOG4105D7K	pfkb domain protein
HPY09_16740	ENOG4108HKT	sucrose-6-phosphate hydrolase
HPY09_16745	ENOG4105ETE	Transcriptional regulator (LacI family
HPY09_16750	ENOG4105C5Y	PTS System
HPY09_16790	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HPY09_16825	ENOG4108RCM	Nitroreductase
HPY09_16830	ENOG41067V3	Antibiotic biosynthesis monooxygenase
HPY09_16835	ENOG4105ETT	transcriptional Regulator, LysR family
HPY09_16845	ENOG4105RA2	Membrane
HPY09_16860	ENOG4108M3J	Dehydrogenase
HPY09_16885	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY09_16895	ENOG4107RHR	regulatoR
HPY09_16900	ENOG4105KHC	sulfurtransferase
HPY09_16910	ENOG4105D06	uba thif-type nad fad binding protein
HPY09_16915	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY09_16920	ENOG4105EUJ	GTP cyclohydrolase i
HPY09_16925	ENOG4105E0X	reductase
HPY09_16930	ENOG4105CKU	formyltetrahydrofolate synthetase
HPY09_16935	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HPY09_16940	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HPY09_16950	ENOG4105JQN	Transcriptional regulator
HPY09_16955	ENOG4105PAD	Hydrolase
HPY09_16960	ENOG4105NXH	GreA GreB family elongation factor
HPY09_16965	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HPY09_16970	ENOG4108JPW	Aminotransferase
HPY09_16975	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HPY09_16990	ENOG4107RCV	ABC transporter, permease
HPY09_17005	ENOG4105DUX	Transporter
HPY09_17030	ENOG4105E43	Extracellular solute-binding protein, family 5
HPY09_17035	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HPY09_17040	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPY09_17045	ENOG4108JQ5	ABC transporter
HPY09_17050	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY09_17065	ENOG4105CYM	Glutathione S-transferase
HPY09_17085	ENOG4105KA0	thioesterase Superfamily protein
HPY09_17100	ENOG4105D05	Receptor
HPY09_17105	ENOG4105CWB	LysR family transcriptional Regulator
HPY09_17110	ENOG4105CD5	CoA-binding domain protein
HPY09_17130	ENOG4108ZJT	translation initiation factor, Sui1
HPY09_17150	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY09_17160	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY09_17165	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY09_17180	ENOG4105BZU	Histidine kinase
HPY09_17190	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY09_17200	ENOG4105BZU	Histidine kinase
HPY09_17230	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HPY09_17240	ENOG4105DU1	integral membrane protein, terc
HPY09_17245	ENOG4105CGH	5'-nucleotidase
HPY09_17250	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
HPY09_17255	ENOG4108UQ5	membrane protein YcdZ
HPY09_17260	ENOG4105DUM	transcriptional regulator, lysR family
HPY09_17265	ENOG4105TMB	Formate nitrite transporter
HPY09_17275	ENOG4105DS1	cytochrome b561
HPY09_17285	ENOG4105EPM	Diguanylate phosphodiesterase
HPY09_17310	ENOG4105C08	Histidine kinase
HPY09_17315	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HPY09_17320	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HPY09_17325	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HPY09_17330	ENOG4105CKI	cobalamin synthesis protein
HPY09_17335	ENOG4105CMQ	Chloride channel
HPY09_17345	ENOG4107KBT	8-Amino-7-oxononanoate synthase
HPY09_17350	ENOG4108MGY	Histidine kinase
HPY09_17355	ENOG4105EYH	Exonuclease
HPY09_17360	ENOG4107RFY	SbcCD D subunit
HPY09_17365	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPY09_17370	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HPY09_17375	ENOG4105DE4	1-phosphofructokinase
HPY09_17380	ENOG4105DM4	PTS System
HPY09_17385	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY09_17390	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY09_17395	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HPY09_17400	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HPY09_17410	ENOG4107VXZ	Hydrolase
HPY09_17415	ENOG4108N3W	hemolysin secretion protein
HPY09_17420	ENOG4105CEE	C4-dicarboxylate transporter
HPY09_17425	ENOG4105EJQ	L-serine dehydratase
HPY09_17430	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY09_17435	ENOG4105BZU	Histidine kinase
HPY09_17450	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY09_17470	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY09_17475	ENOG4108KX4	response regulator
HPY09_17480	ENOG4105BZU	Histidine kinase
HPY09_17485	ENOG4105CXY	transporter
HPY09_17490	ENOG4105C4Y	ABC transporter
HPY09_17495	ENOG4107RCV	ABC transporter, permease
HPY09_17500	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY09_17505	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HPY09_17515	ENOG4105CHU	acetyl-coa acetyltransferase
HPY09_17525	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY09_17530	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY09_17545	ENOG4105BZU	Histidine kinase
HPY09_17550	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY09_17560	ENOG4108I6A	alcohol dehydrogenase
HPY09_17570	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
HPY09_17580	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
HPY09_17585	ENOG4105CXY	transporter
HPY09_17590	ENOG4105CA9	Pyruvate kinase
HPY09_17595	ENOG4105BZU	Histidine kinase
HPY09_17600	ENOG4108SV3	Tmao reductase system periplasmic protein tort
HPY09_17605	ENOG4108Z5K	methylglyoxal synthase
HPY09_17610	ENOG4108RWI	nicotinamidase
HPY09_17615	ENOG41080IJ	Diacylglycerol kinase
HPY09_17620	ENOG41088T4	Helicase IV
HPY09_17625	ENOG4105EM2	membrane
HPY09_17655	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HPY09_17660	ENOG4105E0C	molybdate abc transporter
HPY09_17665	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HPY09_17670	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HPY09_17710	ENOG4105ID8	Transcriptional regulator, ARAC family
HPY09_17720	ENOG4105EYM	Major Facilitator superfamily
HPY09_17725	ENOG4105C0W	non-ribosomal peptide synthetase
HPY09_17750	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY09_17755	ENOG4105C94	Transporter
HPY09_17775	ENOG4105BZ1	(ABC) transporter
HPY09_17780	ENOG4105BZ1	(ABC) transporter
HPY09_17790	ENOG4105BZU	Histidine kinase
HPY09_17795	ENOG4108QGH	periplasmic
HPY09_17805	ENOG41082IR	Excinuclease ABC C subunit domain protein
HPY09_17820	ENOG41090HJ	UPF0265 protein
HPY09_17835	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPY09_17840	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HPY09_17850	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPY09_17855	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY09_17860	ENOG4105K63	Thioredoxin
HPY09_17885	ENOG4105DMR	ABC, transporter
HPY09_17890	ENOG4105GBT	ABC transporter
HPY09_17895	ENOG4106PMH	Extracellular solute-binding protein family 3
HPY09_17900	ENOG4105E5Z	arginine transporter ATP-binding subunit
HPY09_17910	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HPY09_17920	ENOG4108YZ4	nudix hydrolase
HPY09_17925	ENOG4105C5W	Aldolase
HPY09_17930	ENOG4106RE7	Cytochrome
HPY09_17935	ENOG4107XI7	Tetr family transcriptional regulator
HPY09_17940	ENOG4105C1J	atp-dependent rna helicase
HPY09_17945	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HPY09_17950	ENOG4105E0U	tyrosine-specific transport protein
HPY09_17955	ENOG4108N3W	hemolysin secretion protein
HPY09_17960	ENOG4105CMR	udp-glucose 4-epimerase
HPY09_17965	ENOG4105E7W	lamb ycsf family protein
HPY09_17975	ENOG4107R7A	Allophanate hydrolase subunit 2
HPY09_17985	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HPY09_17990	ENOG4105CV6	ABC transporter, permease
HPY09_17995	ENOG4108I0Y	(ABC) transporter
HPY09_18005	ENOG4105RKW	reductase (By
HPY09_18020	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY09_18035	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY09_18050	ENOG4107RE1	Inosine-guanosine kinase
HPY09_18055	ENOG4105E0M	Sulfatase
HPY09_18065	ENOG4105C1J	atp-dependent rna helicase
HPY09_18080	ENOG4105CVA	phosphate
HPY09_18090	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HPY09_18095	ENOG4108M1A	Chitin-binding protein
HPY09_18100	ENOG4105D4Y	metalloprotease
HPY09_18110	ENOG4105CYW	agmatinase
HPY09_18115	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HPY09_18125	ENOG4105CJW	magnesium transporter
HPY09_18130	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY09_18135	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY09_18145	ENOG4105CZK	Aspartate kinase
HPY09_18150	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
HPY09_18155	ENOG4108JPW	Aminotransferase
HPY09_18160	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY09_18165	ENOG41090A4	Pterin carbinolamine dehydratase
HPY09_18170	ENOG4105MIR	Phenylalanine 4-monooxygenase
HPY09_18175	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY09_18190	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY09_18195	ENOG4105EGI	Transcriptional regulator
HPY09_18215	ENOG4105C37	(CBS) domain
HPY09_18220	ENOG4108UKZ	OsmC family
HPY09_18225	ENOG4107YWA	deoxycytidylate deaminase
HPY09_18255	ENOG4105DVH	amino acid
HPY09_18260	ENOG4106TD9	Diguanylate cyclase
HPY09_18270	ENOG4108VAC	response regulator
HPY09_18275	ENOG4108HRK	Histidine kinase
HPY09_18290	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY09_18295	ENOG4105C19	ABC transporter
HPY09_18305	ENOG4107RGM	aldo keto reductase
HPY09_18310	ENOG4107T9C	Alpha amylase catalytic region
HPY09_18320	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY09_18325	ENOG4108M0H	Extracellular lipase
HPY09_18330	ENOG4107SDU	Methyl-accepting chemotaxis
HPY09_18335	ENOG4105D4Y	metalloprotease
HPY09_18340	ENOG4105EIF	outer membrane protein W
HPY09_18350	ENOG41061WM	D-Alanyl-D-Alanine
HPY09_18360	ENOG4105VEQ	Cold shock protein
HPY09_18370	ENOG4105BZC	d-serine deaminase
HPY09_18425	ENOG4107R08	Integrase
HPY09_18445	ENOG4105CPQ	Dehydrogenase
HPY09_18450	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY09_18465	ENOG4105EXG	Transcriptional regulator
HPY09_18470	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HPY09_18490	ENOG4107SSZ	Phosphatase
HPY09_18495	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY09_18500	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HPY09_18510	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPY09_18535	ENOG4105BZW	Glycerate kinase
HPY09_18540	ENOG4105C6Z	Gluconate
HPY09_18545	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HPY09_18550	ENOG4108NVR	Methyl-accepting chemotaxis
HPY09_18555	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HPY09_18560	ENOG41090JE	Utilization Protein
HPY09_18565	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY09_18570	ENOG4105WQ5	TonB family
HPY09_18575	ENOG41090AP	transport protein
HPY09_18580	ENOG4106GFD	transport protein
HPY09_18585	ENOG4107R4I	Periplasmic binding protein
HPY09_18590	ENOG4105EHG	Permease protein
HPY09_18595	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY09_18625	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_18630	ENOG4105QVC	MOSC domain-containing protein
HPY09_18630	ENOG4105QVC	MOSC domain-containing protein
HPY09_18635	ENOG4105EKE	dihydroorotase
HPY09_18640	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
HPY09_18645	ENOG4105CKW	Inner membrane protein yedI
HPY09_18655	ENOG4108ESY	Metal dependent phosphohydrolase
HPY09_18660	ENOG4105VEQ	Cold shock protein
HPY09_18685	ENOG4105BZU	Histidine kinase
HPY09_18690	ENOG4105E98	transcriptional regulator DeoR family
HPY09_18705	ENOG4105EG2	ABC transporter, permease
HPY09_18710	ENOG4105D56	permease protein
HPY09_18715	ENOG4107FKK	extracellular solute-binding protein family 1
HPY09_18720	ENOG4108IJ9	(ABC) transporter
HPY09_18725	ENOG4108HK0	-acetyltransferase
HPY09_18740	ENOG4105K8R	UPF0145 protein
HPY09_18745	ENOG41086KC	Transcriptional regulator
HPY09_18750	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HPY09_18760	ENOG4105K56	Transcriptional regulator
HPY09_18765	ENOG4106TD9	Diguanylate cyclase
HPY09_18780	ENOG4105BZU	Histidine kinase
HPY09_18800	ENOG4105ETT	transcriptional Regulator, LysR family
HPY09_18805	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY09_18815	ENOG4105EUB	pirin domain protein
HPY09_18820	ENOG4105NBK	UPF0345 protein
HPY09_18830	ENOG4105E5W	Transporter
HPY09_18835	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_18840	ENOG4105DAN	ATP-dependent protease
HPY09_18850	ENOG4108JQ5	ABC transporter
HPY09_18855	ENOG4105E89	ABC transporter
HPY09_18860	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_18870	ENOG4105CC0	LysR family Transcriptional regulator
HPY09_18880	ENOG4105DAA	L-lactate
HPY09_18895	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HPY09_18905	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HPY09_18925	ENOG4108RPX	mosc domain containing protein
HPY09_18930	ENOG4105C1J	atp-dependent rna helicase
HPY09_18940	ENOG4105BZ1	(ABC) transporter
HPY09_18950	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY09_18960	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY09_18985	ENOG4105K56	Transcriptional regulator
HPY09_18990	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HPY09_19000	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY09_19005	ENOG4105VW4	glutaredoxin 3
HPY09_19010	ENOG4108P2H	Inner membrane protein YjiG
HPY09_19015	ENOG41074DU	domain protein
HPY09_19020	ENOG4105DN9	Na H antiporter
HPY09_19030	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPY09_19035	ENOG4105D03	DNA-3-methyladenine glycosylase II
HPY09_19040	ENOG4108VGI	doxx family
HPY09_19065	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPY09_19075	ENOG4107W52	maltose operon periplasmic protein
HPY09_19080	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPY09_19095	ENOG4108N3W	hemolysin secretion protein
HPY09_19110	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_19115	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY09_19125	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY09_19130	ENOG4105CDA	abc transporter atp-binding protein
HPY09_19140	ENOG4106TNF	Periplasmic binding protein
HPY09_19145	ENOG4105EZ7	amino acid ABC transporter
HPY09_19150	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HPY09_19155	ENOG4105CTS	PTS system mannitol-specific
HPY09_19160	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HPY09_19165	ENOG4105E61	Mannitol repressor protein
HPY09_19170	ENOG4105EP9	oxidoreductase
HPY09_19200	ENOG4108RYK	Nad-dependent epimerase dehydratase
HPY09_19205	ENOG4105JQN	Transcriptional regulator
HPY09_19210	ENOG41069D7	Methyl-accepting chemotaxis
HPY09_19215	ENOG4105EMU	Dehydrogenase
HPY09_19220	ENOG4105JQN	Transcriptional regulator
HPY09_19240	ENOG4105D5Q	Arginine ornithine antiporter
HPY09_19245	ENOG4105CXN	decarboxylase
HPY09_19255	ENOG4105VJY	transcriptional regulator
HPY09_19275	ENOG4107RGH	Aldehyde dehydrogenase
HPY09_19280	ENOG4105EW9	transcriptional regulator AsnC family
HPY09_19285	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_19295	ENOG4105CK7	Sodium proline symporter
HPY09_19320	ENOG4105E6M	Sulphatase-modifying factor protein
HPY09_19335	ENOG4107QZV	Type I secretion membrane fusion protein
HPY09_19350	ENOG4108JJA	ABC, transporter
HPY09_19370	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_19375	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY09_19385	ENOG4105BZU	Histidine kinase
HPY09_19390	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_19395	ENOG4108V3W	Chemotaxis protein, CheW
HPY09_19400	ENOG4108V3W	Chemotaxis protein, CheW
HPY09_19405	ENOG4105CBS	Chea signal transduction histidine kinase
HPY09_19410	ENOG4108VYJ	response regulator receiver protein
HPY09_19420	ENOG4108NY6	Extracellular solute-binding protein, family 5
HPY09_19425	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY09_19430	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY09_19440	ENOG4105DIJ	Phosphoethanolamine transferase
HPY09_19445	ENOG4105DHQ	Histidine kinase
HPY09_19450	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY09_19460	ENOG4105EMU	Dehydrogenase
HPY09_19480	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HPY09_19485	ENOG4107RUE	extracellular solute-binding protein family 1
HPY09_19595	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY09_19625	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY09_19720	ENOG4105KT5	UmuD protein
HPY09_19740	ENOG4106032	Glutathionylspermidine synthase
HPY09_19760	ENOG4108P9J	Phage shock protein A
HPY09_19780	ENOG4105D13	transposase
HPY09_19795	ENOG4105K4U	addiction module toxin, RelE StbE family
HPY09_20045	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY09_20050	ENOG4105BZU	Histidine kinase
HPY09_20405	ENOG4105DVT	helicase
HPY09_20445	ENOG4105C4R	Atp-dependent dna helicase
HPY09_20480	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY09_20495	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY09_20575	ENOG4105DCY	Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity)
HPY09_20665	ENOG4105C3F	Signal peptidase i
HPY09_20690	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY09_20795	ENOG4105FA0	parb-like partition protein
HPY09_20935	ENOG4105C4R	Atp-dependent dna helicase