locus-tag	class	description
HPY09_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY09_00010	COG0592	DNA-directed DNA polymerase activity
HPY09_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY09_00020	COG0187	DNA topoisomerase II activity
HPY09_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY09_00035	COG3977	Valine--pyruvate aminotransferase
HPY09_00040	COG0751	glycine-tRNA ligase activity
HPY09_00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY09_00050	COG2119	membrane
HPY09_00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY09_00070	COG0604	alcohol dehydrogenase
HPY09_00080	COG0129	dihydroxy-acid dehydratase activity
HPY09_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY09_00100	COG0606	chelatase, subunit chli
HPY09_00105	COG0204	Acyl-transferase
HPY09_00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY09_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY09_00125	COG3084	Protein conserved in bacteria
HPY09_00135	COG4326	sporulation control protein
HPY09_00140	COG1272	protein, Hemolysin III
HPY09_00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY09_00155	COG0569	domain protein
HPY09_00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY09_00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY09_00170	COG0242	peptide deformylase activity
HPY09_00175	COG1652	LysM domain
HPY09_00180	COG0758	DNA mediated transformation
HPY09_00185	COG2922	Belongs to the Smg family
HPY09_00190	COG0551	DNA topoisomerase type I activity
HPY09_00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY09_00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY09_00205	COG0009	L-threonylcarbamoyladenylate synthase
HPY09_00210	COG0408	coproporphyrinogen oxidase activity
HPY09_00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY09_00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY09_00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY09_00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY09_00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY09_00280	COG2104	thiamine diphosphate biosynthetic process
HPY09_00285	COG2022	thiamine diphosphate biosynthetic process
HPY09_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY09_00295	COG0006	proline dipeptidase activity
HPY09_00295	COG0006	proline dipeptidase activity
HPY09_00315	COG1522	sequence-specific DNA binding
HPY09_00320	COG5001	Diguanylate cyclase
HPY09_00320	COG5002	protein histidine kinase activity
HPY09_00340	COG0589	response to stress
HPY09_00345	COG1528	Iron-storage protein
HPY09_00355	COG2081	HI0933 family
HPY09_00365	COG1322	Protein conserved in bacteria
HPY09_00370	COG2226	methyltransferase
HPY09_00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY09_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY09_00395	COG0805	protein transport
HPY09_00400	COG1858	cytochrome C peroxidase
HPY09_00405	COG0534	Mate efflux family protein
HPY09_00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY09_00420	COG2937	Belongs to the GPAT DAPAT family
HPY09_00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY09_00430	COG3161	chorismate lyase activity
HPY09_00435	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY09_00440	COG0840	transmembrane signaling receptor activity
HPY09_00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY09_00455	COG0084	hydrolase, TatD family'
HPY09_00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY09_00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY09_00490	COG3078	GTPase activator activity
HPY09_00505	COG3071	HemY protein
HPY09_00510	COG2959	enzyme of heme biosynthesis
HPY09_00515	COG1587	Uroporphyrinogen-III synthase
HPY09_00520	COG0181	hydroxymethylbilane synthase activity
HPY09_00530	COG1965	Belongs to the frataxin family
HPY09_00540	COG0019	diaminopimelate decarboxylase activity
HPY09_00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY09_00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY09_00560	COG1011	Hydrolase
HPY09_00565	COG2200	EAL domain
HPY09_00565	COG3287	FIST C domain
HPY09_00565	COG2199	diguanylate cyclase activity
HPY09_00580	COG0561	phosphatase activity
HPY09_00585	COG2267	carboxylic ester hydrolase activity
HPY09_00590	COG1280	lysine exporter protein (LysE YggA)
HPY09_00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY09_00600	COG0783	Belongs to the Dps family
HPY09_00630	COG0742	ribosomal rna small subunit methyltransferase
HPY09_00635	COG0552	protein localization to endoplasmic reticulum
HPY09_00640	COG2884	Cell division ATP-binding protein ftsE
HPY09_00645	COG2177	Part of the ABC transporter FtsEX involved in
HPY09_00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY09_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY09_00680	COG1404	Belongs to the peptidase S8 family
HPY09_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY09_00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY09_00755	COG3300	MHYT domain
HPY09_00755	COG5001	Diguanylate cyclase
HPY09_00765	COG3852	Histidine kinase
HPY09_00775	COG0174	glutamine synthetase
HPY09_00795	COG1295	ribonuclease BN
HPY09_00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY09_00805	COG0456	acetyltransferase
HPY09_00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY09_00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY09_00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY09_00830	COG3031	protein transport across the cell outer membrane
HPY09_00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY09_00845	COG1459	type II secretion system
HPY09_00850	COG2165	general secretion pathway protein
HPY09_00855	COG2165	general secretion pathway protein
HPY09_00860	COG2165	general secretion pathway protein
HPY09_00865	COG4795	General secretion pathway protein
HPY09_00870	COG3156	type II secretion system protein K
HPY09_00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY09_00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY09_00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY09_00895	COG0494	nUDIX hydrolase
HPY09_00905	COG1040	competence protein
HPY09_00915	COG0596	Alpha beta hydrolase
HPY09_00925	COG2183	response to ionizing radiation
HPY09_00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY09_00935	COG2199	diguanylate cyclase activity
HPY09_00940	COG0745	RESPONSE REGULATOR receiver
HPY09_00950	COG2233	PERMEase
HPY09_00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY09_00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY09_00965	COG1758	RNA polymerase activity
HPY09_00970	COG0194	GDP metabolic process
HPY09_00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY09_00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY09_01000	COG4232	protein-disulfide reductase activity
HPY09_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY09_01015	COG1027	Aspartate ammonia-lyase
HPY09_01020	COG3706	GGDEF domain
HPY09_01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY09_01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY09_01040	COG2205	protein histidine kinase activity
HPY09_01045	COG0745	RESPONSE REGULATOR receiver
HPY09_01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY09_01060	COG0205	6-phosphofructokinase activity
HPY09_01065	COG1494	fructose-1,6-bisphosphatase
HPY09_01070	COG3074	FtsZ-dependent cytokinesis
HPY09_01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY09_01080	COG0527	aspartate kinase activity
HPY09_01080	COG0460	homoserine dehydrogenase
HPY09_01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY09_01095	COG0281	malic enzyme
HPY09_01100	COG0254	rRNA binding
HPY09_01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY09_01110	COG1609	Transcriptional regulator
HPY09_01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY09_01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY09_01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY09_01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY09_01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY09_01140	COG0534	Mate efflux family protein
HPY09_01145	COG0149	triose-phosphate isomerase activity
HPY09_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY09_01175	COG0459	protein refolding
HPY09_01185	COG1509	lysine 2,3-aminomutase activity
HPY09_01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY09_01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY09_01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY09_01210	COG1053	succinate dehydrogenase
HPY09_01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY09_01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY09_01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY09_01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY09_01235	COG1045	serine acetyltransferase
HPY09_01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY09_01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY09_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY09_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY09_01265	COG0137	argininosuccinate synthase activity
HPY09_01270	COG0165	Argininosuccinate lyase
HPY09_01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_01285	COG0678	peroxiredoxin activity
HPY09_01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY09_01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY09_01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY09_01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY09_01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY09_01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY09_01350	COG0546	phosphoglycolate phosphatase activity
HPY09_01355	COG0180	Tryptophanyl-tRNA synthetase
HPY09_01375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY09_01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY09_01395	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_01410	COG3954	Phosphoribulokinase
HPY09_01420	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY09_01430	COG0488	(ABC) transporter
HPY09_01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY09_01450	COG1047	Peptidyl-prolyl cis-trans
HPY09_01460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY09_01465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY09_01475	COG0557	exoribonuclease II activity
HPY09_01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY09_01485	COG0051	transcription antitermination factor activity, RNA binding
HPY09_01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY09_01495	COG0088	Forms part of the polypeptide exit tunnel
HPY09_01500	COG0089	rRNA binding
HPY09_01505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY09_01510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY09_01515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY09_01520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY09_01525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY09_01530	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY09_01535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY09_01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY09_01545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY09_01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY09_01555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY09_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY09_01565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY09_01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY09_01575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY09_01580	COG1841	ribosomal large subunit assembly
HPY09_01590	COG0201	protein transport
HPY09_01595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY09_01600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY09_01605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY09_01610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY09_01615	COG0202	RNA polymerase activity
HPY09_01620	COG0203	ribosomal protein L17
HPY09_01630	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY09_01635	COG3061	Opacity-associated protein A
HPY09_01635	COG3266	domain, Protein
HPY09_01640	COG0697	spore germination
HPY09_01645	COG2153	protein acetylation
HPY09_01650	COG0513	Belongs to the DEAD box helicase family
HPY09_01660	COG0737	Belongs to the 5'-nucleotidase family
HPY09_01665	COG1648	precorrin-2 dehydrogenase activity
HPY09_01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY09_01670	COG0175	sulfate reduction
HPY09_01675	COG2895	sulfate adenylyltransferase (ATP) activity
HPY09_01680	COG0529	Catalyzes the synthesis of activated sulfate
HPY09_01700	COG1136	(ABC) transporter
HPY09_01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY09_01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_01725	COG0729	surface antigen
HPY09_01735	COG2105	PFAM AIG2 family protein
HPY09_01740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY09_01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY09_01755	COG0163	prenyltransferase activity
HPY09_01765	COG1178	ABC-type Fe3 transport system permease component
HPY09_01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY09_01775	COG3028	Belongs to the UPF0307 family
HPY09_01780	COG0312	modulator of DNA gyrase
HPY09_01785	COG2239	Acts as a magnesium transporter
HPY09_01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_01795	COG1660	Displays ATPase and GTPase activities
HPY09_01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY09_01815	COG1137	ATPase activity
HPY09_01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY09_01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY09_01835	COG0517	IMP dehydrogenase activity
HPY09_01845	COG1127	ABC transporter
HPY09_01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY09_01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY09_01860	COG2854	intermembrane phospholipid transfer
HPY09_01870	COG5007	Belongs to the BolA IbaG family
HPY09_01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY09_01885	COG0251	oxidation-reduction process
HPY09_01895	COG0540	Belongs to the ATCase OTCase family
HPY09_01905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY09_01920	COG0564	pseudouridine synthase activity
HPY09_01925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY09_01930	COG0525	valine-tRNA ligase activity
HPY09_01935	COG2927	DNA polymerase III (CHI subunit)
HPY09_01940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY09_01945	COG0795	lipopolysaccharide-transporting ATPase activity
HPY09_01950	COG0795	lipopolysaccharide-transporting ATPase activity
HPY09_01965	COG3437	response regulator, receiver
HPY09_02005	COG0066	3-isopropylmalate dehydratase activity
HPY09_02010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY09_02015	COG0473	3-isopropylmalate dehydrogenase activity
HPY09_02045	COG1022	Amp-dependent synthetase and ligase
HPY09_02050	COG0028	Belongs to the TPP enzyme family
HPY09_02055	COG0440	acetolactate synthase activity
HPY09_02060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY09_02065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY09_02070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY09_02080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY09_02085	COG3079	Belongs to the UPF0149 family
HPY09_02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY09_02120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY09_02125	COG1595	DNA-templated transcription, initiation
HPY09_02140	COG3086	response to oxidative stress
HPY09_02145	COG0481	GTPase activity
HPY09_02155	COG0571	ribonuclease III activity
HPY09_02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY09_02165	COG1381	Involved in DNA repair and RecF pathway recombination
HPY09_02170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY09_02175	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY09_02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY09_02210	COG3956	TIGRFAM MazG family protein
HPY09_02215	COG0504	CTP synthase activity
HPY09_02220	COG0148	phosphopyruvate hydratase activity
HPY09_02225	COG0617	tRNA 3'-terminal CCA addition
HPY09_02230	COG3409	Peptidoglycan-binding domain 1 protein
HPY09_02230	COG3267	Type II secretory pathway component ExeA
HPY09_02240	COG4991	sh3 domain protein
HPY09_02245	COG0306	phosphate transporter
HPY09_02250	COG1392	Phosphate transport regulator
HPY09_02255	COG3025	triphosphatase activity
HPY09_02260	COG0840	transmembrane signaling receptor activity
HPY09_02265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY09_02275	COG1538	Outer membrane efflux protein
HPY09_02280	COG0494	nUDIX hydrolase
HPY09_02285	COG3151	Protein conserved in bacteria
HPY09_02295	COG3150	esterase
HPY09_02300	COG0187	DNA topoisomerase II activity
HPY09_02305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY09_02315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY09_02320	COG0237	dephospho-CoA kinase activity
HPY09_02330	COG1459	type II secretion system
HPY09_02335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY09_02355	COG0716	FMN binding
HPY09_02360	COG4974	Belongs to the 'phage' integrase family
HPY09_02365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY09_02370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY09_02375	COG2186	Transcriptional regulator
HPY09_02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY09_02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY09_02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_02405	COG3116	cell division
HPY09_02410	COG0768	penicillin binding
HPY09_02415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY09_02420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY09_02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY09_02435	COG0772	Belongs to the SEDS family
HPY09_02440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY09_02445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY09_02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY09_02455	COG0849	cell division
HPY09_02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY09_02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY09_02475	COG0653	protein targeting
HPY09_02480	COG0494	nUDIX hydrolase
HPY09_02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY09_02495	COG0505	Belongs to the CarA family
HPY09_02500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY09_02520	COG0730	response to heat
HPY09_02525	COG0583	DNA-binding transcription factor activity
HPY09_02530	COG2860	membrane
HPY09_02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY09_02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY09_02555	COG0493	'glutamate synthase
HPY09_02560	COG0070	glutamate synthase
HPY09_02560	COG0069	glutamate synthase activity
HPY09_02560	COG0067	glutamate synthase
HPY09_02570	COG0067	glutamate synthase
HPY09_02570	COG0069	glutamate synthase activity
HPY09_02570	COG0070	glutamate synthase
HPY09_02580	COG2203	Gaf domain
HPY09_02580	COG3706	GGDEF domain
HPY09_02580	COG4251	negative regulation of phosphorylation
HPY09_02580	COG5001	Diguanylate cyclase
HPY09_02585	COG0784	Response regulator, receiver
HPY09_02585	COG5002	protein histidine kinase activity
HPY09_02585	COG2198	Histidine kinase
HPY09_02590	COG0745	RESPONSE REGULATOR receiver
HPY09_02600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY09_02620	COG0083	homoserine kinase activity
HPY09_02625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY09_02630	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY09_02635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY09_02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY09_02655	COG1115	amino acid carrier protein
HPY09_02660	COG3022	response to hydroperoxide
HPY09_02670	COG0084	hydrolase, TatD family'
HPY09_02675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY09_02685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY09_02690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY09_02695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY09_02700	COG0813	purine-nucleoside phosphorylase activity
HPY09_02710	COG0560	Phosphoserine phosphatase
HPY09_02720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY09_02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY09_02730	COG1022	Amp-dependent synthetase and ligase
HPY09_02745	COG3250	beta-galactosidase activity
HPY09_02750	COG1609	Transcriptional regulator
HPY09_02755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_02770	COG0569	domain protein
HPY09_02770	COG0189	ligase activity
HPY09_02775	COG0456	acetyltransferase
HPY09_02785	COG2171	N-acyltransferase activity
HPY09_02790	COG3141	response to X-ray
HPY09_02805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY09_02810	COG1074	ATP-dependent DNA helicase activity
HPY09_02815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY09_02825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY09_02825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY09_02835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY09_02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY09_02845	COG2166	iron-sulfur cluster assembly
HPY09_02850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY09_02855	COG0693	protein deglycase activity
HPY09_02860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY09_02865	COG3248	Nucleoside-binding outer membrane protein
HPY09_02875	COG1595	DNA-templated transcription, initiation
HPY09_02885	COG2211	Major facilitator Superfamily
HPY09_02890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY09_02900	COG2813	Specifically methylates the guanine in position
HPY09_02905	COG0271	Belongs to the BolA IbaG family
HPY09_02910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY09_02915	COG1805	sodium ion transport
HPY09_02920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY09_02930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY09_02935	COG2871	sodium ion transport
HPY09_02940	COG1477	protein flavinylation
HPY09_02960	COG3706	GGDEF domain
HPY09_02965	COG0733	neurotransmitter:sodium symporter activity
HPY09_02970	COG3385	transposase activity
HPY09_02980	COG0189	ligase activity
HPY09_02985	COG0189	ligase activity
HPY09_02985	COG4067	protein conserved in archaea
HPY09_02990	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY09_02995	COG2252	PERMEase
HPY09_03000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY09_03015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY09_03020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY09_03025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY09_03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_03045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY09_03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY09_03055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY09_03060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY09_03070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY09_03075	COG0024	Methionine aminopeptidase
HPY09_03080	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY09_03085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY09_03090	COG0528	UMP kinase activity
HPY09_03095	COG0233	cytoplasmic translational termination
HPY09_03100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY09_03105	COG0575	Belongs to the CDS family
HPY09_03110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY09_03115	COG0750	zinc metalloprotease
HPY09_03125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY09_03130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_03135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY09_03140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_03145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY09_03155	COG0587	DNA-directed DNA polymerase activity
HPY09_03160	COG0825	malonyl-CoA metabolic process
HPY09_03165	COG0037	tRNA processing
HPY09_03175	COG3479	Phenolic acid decarboxylase
HPY09_03180	COG0347	Belongs to the P(II) protein family
HPY09_03185	COG3021	interspecies interaction between organisms
HPY09_03190	COG0741	lytic transglycosylase activity
HPY09_03190	COG1388	LysM domain
HPY09_03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY09_03200	COG2226	methyltransferase
HPY09_03205	COG0328	RNA-DNA hybrid ribonuclease activity
HPY09_03220	COG1960	acyl-CoA dehydrogenase activity
HPY09_03225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY09_03230	COG0121	glutamine amidotransferase
HPY09_03235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY09_03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY09_03245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY09_03250	COG3706	GGDEF domain
HPY09_03255	COG1187	pseudouridine synthase activity
HPY09_03260	COG2840	Smr protein MutS2
HPY09_03290	COG2608	mercury ion transmembrane transporter activity
HPY09_03290	COG2217	Heavy metal translocating P-type atpase
HPY09_03295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY09_03310	COG1629	transport
HPY09_03310	COG4774	siderophore transport
HPY09_03315	COG2375	cellular response to nickel ion
HPY09_03320	COG3433	isochorismatase activity
HPY09_03320	COG2226	methyltransferase
HPY09_03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY09_03355	COG0835	chemotaxis
HPY09_03355	COG0784	Response regulator, receiver
HPY09_03360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY09_03365	COG1815	bacterial-type flagellum-dependent cell motility
HPY09_03380	COG1749	Flagellar hook protein flgE
HPY09_03385	COG4787	bacterial-type flagellum-dependent cell motility
HPY09_03395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY09_03400	COG1706	bacterial-type flagellum-dependent cell motility
HPY09_03405	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY09_03405	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY09_03420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_03425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_03510	COG0012	GTP binding
HPY09_03515	COG0193	aminoacyl-tRNA hydrolase activity
HPY09_03520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY09_03525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY09_03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY09_03535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY09_03540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY09_03545	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY09_03555	COG2912	Transglutaminase-like superfamily
HPY09_03560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY09_03565	COG0737	Belongs to the 5'-nucleotidase family
HPY09_03570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY09_03575	COG2233	PERMEase
HPY09_03595	COG1393	Belongs to the ArsC family
HPY09_03600	COG4783	chaperone-mediated protein folding
HPY09_03620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY09_03635	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY09_03645	COG1876	peptidase activity
HPY09_03655	COG1393	Belongs to the ArsC family
HPY09_03675	COG2837	iron assimilation
HPY09_03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_03685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_03695	COG1334	flagellar protein FlaG
HPY09_03700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY09_03710	COG1516	flagellar protein fliS
HPY09_03720	COG4191	Histidine kinase
HPY09_03730	COG1677	Flagellar hook-basal body complex protein FliE
HPY09_03740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY09_03745	COG1317	bacterial-type flagellum organization
HPY09_03770	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY09_03795	COG1987	bacterial-type flagellum assembly
HPY09_03800	COG1684	flagellar biosynthetic protein fliR
HPY09_03810	COG2840	Smr protein MutS2
HPY09_03815	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY09_03820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY09_03825	COG2860	membrane
HPY09_03830	COG3101	peptidyl-lysine hydroxylation
HPY09_03840	COG0431	NADPH-dependent FMN reductase
HPY09_03845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY09_03845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY09_03850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY09_03855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY09_03860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY09_03865	COG0735	belongs to the Fur family
HPY09_03875	COG0583	DNA-binding transcription factor activity
HPY09_03885	COG1346	cytolysis
HPY09_03900	COG0596	Alpha beta hydrolase
HPY09_03905	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY09_03910	COG0033	Phosphoglucomutase
HPY09_03920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY09_03925	COG0372	Belongs to the citrate synthase family
HPY09_03930	COG2009	succinate dehydrogenase
HPY09_03935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY09_03940	COG1053	succinate dehydrogenase
HPY09_03950	COG0567	Dehydrogenase, E1 component
HPY09_03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY09_03960	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY09_03970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY09_03975	COG1121	(ABC) transporter
HPY09_03980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY09_03985	COG4977	sequence-specific DNA binding
HPY09_03990	COG1918	ferrous iron import across plasma membrane
HPY09_04010	COG0018	arginyl-trna synthetase
HPY09_04020	COG1025	Belongs to the peptidase M16 family
HPY09_04025	COG2062	phosphohistidine phosphatase, SixA
HPY09_04055	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY09_04060	COG0643	Histidine kinase
HPY09_04060	COG2198	Histidine kinase
HPY09_04060	COG0784	Response regulator, receiver
HPY09_04065	COG2201	protein-glutamate methylesterase activity
HPY09_04070	COG1192	Involved in chromosome partitioning
HPY09_04080	COG0835	chemotaxis
HPY09_04090	COG4133	protoheme IX ABC transporter activity
HPY09_04095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY09_04100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY09_04110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY09_04115	COG1138	Cytochrome C-type biogenesis protein
HPY09_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY09_04135	COG2853	Lipoprotein
HPY09_04155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY09_04160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY09_04165	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY09_04180	COG3083	sulfuric ester hydrolase activity
HPY09_04185	COG3082	Protein of unknown function (DUF1414)
HPY09_04190	COG3081	Nucleoid-associated protein
HPY09_04200	COG1757	Na H antiporter
HPY09_04205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY09_04210	COG2095	MarC family integral membrane protein
HPY09_04215	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_04215	COG1454	alcohol dehydrogenase
HPY09_04225	COG0659	secondary active sulfate transmembrane transporter activity
HPY09_04230	COG1530	ribonuclease E activity
HPY09_04235	COG0564	pseudouridine synthase activity
HPY09_04240	COG0424	maF-like protein
HPY09_04245	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY09_04250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY09_04255	COG0416	fatty acid biosynthetic process
HPY09_04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY09_04270	COG1028	Short-chain dehydrogenase reductase Sdr
HPY09_04275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY09_04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY09_04285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY09_04290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY09_04295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY09_04305	COG0084	hydrolase, TatD family'
HPY09_04310	COG1263	PTS System
HPY09_04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_04320	COG0733	neurotransmitter:sodium symporter activity
HPY09_04345	COG1940	carbohydrate kinase activity
HPY09_04350	COG0835	chemotaxis
HPY09_04350	COG0784	Response regulator, receiver
HPY09_04365	COG2226	methyltransferase
HPY09_04375	COG0676	glucose-6-phosphate 1-epimerase activity
HPY09_04380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY09_04385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_04395	COG3139	Protein of unknown function (DUF1315)
HPY09_04400	COG0252	asparaginase activity
HPY09_04405	COG0616	signal peptide processing
HPY09_04410	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY09_04410	COG1902	pentaerythritol trinitrate reductase activity
HPY09_04415	COG0788	formyltetrahydrofolate deformylase activity
HPY09_04425	COG1199	ATP-dependent helicase activity
HPY09_04430	COG1214	PFAM Peptidase M22, glycoprotease
HPY09_04445	COG0596	Alpha beta hydrolase
HPY09_04450	COG0318	PFAM AMP-dependent synthetase and ligase
HPY09_04455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY09_04475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY09_04480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY09_04485	COG0436	Aminotransferase
HPY09_04490	COG1169	isochorismate synthase
HPY09_04495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY09_04500	COG0596	Alpha beta hydrolase
HPY09_04520	COG3135	benzoate transporter
HPY09_04545	COG3015	lipoprotein NlpE involved in copper resistance
HPY09_04550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY09_04555	COG2894	cell division
HPY09_04560	COG0850	regulation of cytokinetic process
HPY09_04565	COG3100	YcgL domain-containing protein
HPY09_04570	COG2951	lytic endotransglycosylase activity
HPY09_04580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY09_04585	COG3005	denitrification pathway
HPY09_04590	COG0243	molybdopterin cofactor binding
HPY09_04605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_04620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY09_04655	COG4589	Belongs to the CDS family
HPY09_04665	COG5001	Diguanylate cyclase
HPY09_04665	COG3300	MHYT domain
HPY09_04675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY09_04680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY09_04685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY09_04690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY09_04700	COG4191	Histidine kinase
HPY09_04710	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY09_04720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY09_04725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY09_04730	COG0776	regulation of translation
HPY09_04735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY09_04740	COG1555	photosystem II stabilization
HPY09_04745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY09_04750	COG0539	negative regulation of cytoplasmic translation
HPY09_04755	COG0776	regulation of translation
HPY09_04760	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY09_04765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY09_04785	COG0583	DNA-binding transcription factor activity
HPY09_04795	COG0686	Belongs to the AlaDH PNT family
HPY09_04805	COG1674	ftsk spoiiie
HPY09_04810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY09_04815	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY09_04820	COG2186	Transcriptional regulator
HPY09_04835	COG0537	adenosine 5'-monophosphoramidase activity
HPY09_04860	COG3150	esterase
HPY09_04865	COG1252	NADH dehydrogenase
HPY09_04890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY09_04900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY09_04905	COG1136	(ABC) transporter
HPY09_04910	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY09_04920	COG0658	competence protein
HPY09_04920	COG2333	competence protein COMEC
HPY09_04925	COG1132	(ABC) transporter
HPY09_04930	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY09_04935	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY09_04940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY09_04945	COG2719	SpoVR family
HPY09_04950	COG2718	Belongs to the UPF0229 family
HPY09_04955	COG2766	serine protein kinase
HPY09_04960	COG3385	transposase activity
HPY09_04965	COG3013	Belongs to the UPF0304 family
HPY09_04975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY09_04980	COG0840	transmembrane signaling receptor activity
HPY09_04990	COG1882	Formate acetyltransferase
HPY09_05015	COG4160	amino acid transport
HPY09_05020	COG0708	Exodeoxyribonuclease III
HPY09_05030	COG3923	Primosomal replication protein n
HPY09_05035	COG0730	response to heat
HPY09_05040	COG1199	ATP-dependent helicase activity
HPY09_05050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY09_05055	COG3012	SEC-C Motif Domain Protein
HPY09_05060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY09_05065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY09_05075	COG0215	cysteine-tRNA ligase activity
HPY09_05080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY09_05085	COG0632	four-way junction helicase activity
HPY09_05095	COG1271	oxidase subunit
HPY09_05100	COG1294	oxidase, subunit
HPY09_05105	COG4890	Cyd operon protein YbgT
HPY09_05110	COG3790	cyd operon protein YbgE
HPY09_05115	COG0824	Thioesterase
HPY09_05120	COG0811	peptide transport
HPY09_05135	COG0823	Involved in the tonB-independent uptake of proteins
HPY09_05140	COG2885	chlorophyll binding
HPY09_05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY09_05160	COG0784	Response regulator, receiver
HPY09_05160	COG5002	protein histidine kinase activity
HPY09_05170	COG1482	cell wall glycoprotein biosynthetic process
HPY09_05175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_05175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_05180	COG2207	Transcriptional regulator
HPY09_05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_05210	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_05215	COG3284	Transcriptional regulator
HPY09_05220	COG4628	conserved protein (DUF2132)
HPY09_05230	COG0415	Belongs to the DNA photolyase family
HPY09_05315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY09_05325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY09_05365	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HPY09_05410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY09_05425	COG0681	Belongs to the peptidase S26 family
HPY09_05470	COG3064	Membrane
HPY09_05500	COG2351	hydroxyisourate hydrolase activity
HPY09_05515	COG5492	domain, Protein
HPY09_05515	COG4932	domain protein
HPY09_05540	COG4796	Type ii and iii secretion system protein
HPY09_05565	COG1459	type II secretion system
HPY09_05585	COG2207	Transcriptional regulator
HPY09_05630	COG3710	Transcriptional regulator
HPY09_05635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY09_05680	COG0629	single-stranded DNA binding
HPY09_05700	COG0714	Associated with various cellular activities
HPY09_05725	COG2003	Belongs to the UPF0758 family
HPY09_05765	COG3311	Transcriptional regulator
HPY09_05770	COG0582	viral genome integration into host DNA
HPY09_05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_05795	COG3008	intermembrane lipid transfer
HPY09_05795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY09_05800	COG2995	paraquat-inducible protein a
HPY09_05805	COG0668	transmembrane transport
HPY09_05825	COG1309	transcriptional regulator
HPY09_05830	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_05855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY09_05860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY09_05865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY09_05870	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY09_05885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY09_05890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY09_05895	COG0297	glycogen (starch) synthase activity
HPY09_05915	COG3070	regulator of competence-specific genes
HPY09_05920	COG1609	Transcriptional regulator
HPY09_05930	COG0745	RESPONSE REGULATOR receiver
HPY09_05935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY09_05940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY09_05945	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY09_05950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY09_05965	COG1280	lysine exporter protein (LysE YggA)
HPY09_05970	COG1032	radical SAM domain protein
HPY09_05975	COG5001	Diguanylate cyclase
HPY09_05980	COG0612	Peptidase, M16
HPY09_05995	COG0583	DNA-binding transcription factor activity
HPY09_06000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY09_06010	COG2350	Protein conserved in bacteria
HPY09_06015	COG1607	acyl-coa hydrolase
HPY09_06030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY09_06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY09_06045	COG2116	formate transmembrane transporter activity
HPY09_06050	COG4459	periplasmic nitrate reductase
HPY09_06055	COG3005	denitrification pathway
HPY09_06060	COG0243	molybdopterin cofactor binding
HPY09_06080	COG1227	inorganic diphosphatase activity
HPY09_06100	COG4172	Belongs to the ABC transporter superfamily
HPY09_06115	COG4168	peptide transport system, permease
HPY09_06125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY09_06130	COG1842	Phage shock protein A
HPY09_06145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_06160	COG2818	Glycosylase
HPY09_06165	COG0626	cystathionine gamma-synthase activity
HPY09_06175	COG0733	neurotransmitter:sodium symporter activity
HPY09_06180	COG0564	pseudouridine synthase activity
HPY09_06185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY09_06190	COG4136	ATPase activity
HPY09_06195	COG4135	transport system, permease component
HPY09_06200	COG4134	Bacterial extracellular solute-binding protein
HPY09_06210	COG3313	Fe-S protein
HPY09_06220	COG0814	amino acid
HPY09_06230	COG2239	Acts as a magnesium transporter
HPY09_06235	COG0784	Response regulator, receiver
HPY09_06235	COG2205	protein histidine kinase activity
HPY09_06250	COG4934	collagen metabolic process
HPY09_06285	COG0840	transmembrane signaling receptor activity
HPY09_06295	COG4251	negative regulation of phosphorylation
HPY09_06295	COG3706	GGDEF domain
HPY09_06295	COG2203	Gaf domain
HPY09_06295	COG5001	Diguanylate cyclase
HPY09_06300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY09_06305	COG5002	protein histidine kinase activity
HPY09_06320	COG1061	Type III restriction enzyme res subunit
HPY09_06325	COG1187	pseudouridine synthase activity
HPY09_06330	COG2814	Major facilitator Superfamily
HPY09_06340	COG0702	epimerase
HPY09_06345	COG0534	Mate efflux family protein
HPY09_06350	COG4181	ATPase activity
HPY09_06365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY09_06375	COG1748	Saccharopine dehydrogenase
HPY09_06390	COG1538	Outer membrane efflux protein
HPY09_06460	COG0583	DNA-binding transcription factor activity
HPY09_06470	COG1451	nucleotide metabolic process
HPY09_06485	COG3063	Type IV pilus biogenesis stability protein PilW
HPY09_06490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY09_06510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_06525	COG3290	protein histidine kinase activity
HPY09_06530	COG4565	transcriptional regulatory protein
HPY09_06540	COG0784	Response regulator, receiver
HPY09_06540	COG0835	chemotaxis
HPY09_06590	COG1085	galactose-1-phosphate uridylyltransferase
HPY09_06595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY09_06600	COG2017	converts alpha-aldose to the beta-anomer
HPY09_06615	COG3527	Alpha-acetolactate decarboxylase
HPY09_06625	COG3064	Membrane
HPY09_06635	COG0753	catalase activity
HPY09_06655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY09_06705	COG1271	oxidase subunit
HPY09_06710	COG1294	oxidase, subunit
HPY09_06715	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY09_06715	COG1136	(ABC) transporter
HPY09_06720	COG1136	(ABC) transporter
HPY09_06720	COG0577	efflux transmembrane transporter activity
HPY09_06725	COG0577	efflux transmembrane transporter activity
HPY09_06725	COG1136	(ABC) transporter
HPY09_06775	COG2816	NAD+ diphosphatase activity
HPY09_06780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY09_06795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY09_06805	COG2723	6-phospho-beta-galactosidase activity
HPY09_06810	COG1609	Transcriptional regulator
HPY09_06815	COG0251	oxidation-reduction process
HPY09_06820	COG2731	YhcH YjgK YiaL family protein
HPY09_06825	COG0584	glycerophosphoryl diester phosphodiesterase
HPY09_06830	COG1349	DNA-binding transcription factor activity
HPY09_06835	COG3842	ATPase activity
HPY09_06840	COG0395	ABC-type sugar transport system, permease component
HPY09_06845	COG1175	transmembrane transport
HPY09_06860	COG0811	peptide transport
HPY09_06865	COG0811	peptide transport
HPY09_06870	COG0848	biopolymer transport protein
HPY09_06875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY09_06885	COG1793	dna ligase
HPY09_06895	COG0534	Mate efflux family protein
HPY09_06905	COG3001	Fructosamine kinase
HPY09_06915	COG0791	NLP P60 protein
HPY09_06920	COG0840	transmembrane signaling receptor activity
HPY09_06935	COG1940	carbohydrate kinase activity
HPY09_06955	COG0746	molybdenum cofactor guanylyltransferase activity
HPY09_06960	COG3842	ATPase activity
HPY09_06965	COG4662	Binding-protein-dependent transport system inner membrane component
HPY09_06975	COG2204	response regulator
HPY09_06980	COG3852	Histidine kinase
HPY09_06985	COG0488	(ABC) transporter
HPY09_06990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY09_07020	COG3383	formate dehydrogenase (NAD+) activity
HPY09_07020	COG0243	molybdopterin cofactor binding
HPY09_07025	COG0437	4 iron, 4 sulfur cluster binding
HPY09_07040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY09_07045	COG1666	GTP binding
HPY09_07050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY09_07065	COG2996	Protein conserved in bacteria
HPY09_07075	COG3008	intermembrane lipid transfer
HPY09_07080	COG2995	paraquat-inducible protein a
HPY09_07085	COG1132	(ABC) transporter
HPY09_07090	COG1956	GAF domain-containing protein
HPY09_07095	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY09_07110	COG0308	aminopeptidase N
HPY09_07125	COG0167	dihydroorotate dehydrogenase activity
HPY09_07135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY09_07135	COG0116	Belongs to the methyltransferase superfamily
HPY09_07160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY09_07165	COG1067	ATP-dependent peptidase activity
HPY09_07170	COG3120	sequence-specific DNA binding
HPY09_07270	COG1073	alpha beta
HPY09_07270	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY09_07270	COG3064	Membrane
HPY09_07275	COG2994	toxin metabolic process
HPY09_07300	COG2205	protein histidine kinase activity
HPY09_07300	COG0784	Response regulator, receiver
HPY09_07315	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY09_07330	COG2010	Cytochrome c
HPY09_07340	COG2217	Heavy metal translocating P-type atpase
HPY09_07355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY09_07360	COG0589	response to stress
HPY09_07365	COG0037	tRNA processing
HPY09_07385	COG3842	ATPase activity
HPY09_07395	COG1177	transmembrane transport
HPY09_07405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY09_07420	COG1115	amino acid carrier protein
HPY09_07425	COG1280	lysine exporter protein (LysE YggA)
HPY09_07455	COG3501	Rhs element vgr protein
HPY09_07465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY09_07485	COG0513	Belongs to the DEAD box helicase family
HPY09_07490	COG2076	Multidrug Resistance protein
HPY09_07495	COG0415	Belongs to the DNA photolyase family
HPY09_07500	COG0477	Major facilitator Superfamily
HPY09_07505	COG0583	DNA-binding transcription factor activity
HPY09_07515	COG0402	S-adenosylhomocysteine deaminase activity
HPY09_07520	COG0095	Lipoate-protein ligase
HPY09_07525	COG0443	Heat shock 70 kDa protein
HPY09_07535	COG1643	Atp-dependent helicase
HPY09_07565	COG0443	Heat shock 70 kDa protein
HPY09_07570	COG0443	Heat shock 70 kDa protein
HPY09_07575	COG3706	GGDEF domain
HPY09_07605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY09_07610	COG0602	queuosine metabolic process
HPY09_07615	COG0561	phosphatase activity
HPY09_07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_07630	COG4597	amino acid ABC transporter
HPY09_07635	COG0765	amino acid transport
HPY09_07640	COG1126	abc transporter atp-binding protein
HPY09_07645	COG0670	Belongs to the BI1 family
HPY09_07650	COG2920	part of a sulfur-relay system
HPY09_07655	COG1254	Belongs to the acylphosphatase family
HPY09_07660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY09_07665	COG3706	GGDEF domain
HPY09_07675	COG3437	response regulator, receiver
HPY09_07675	COG2205	protein histidine kinase activity
HPY09_07675	COG3850	Histidine kinase
HPY09_07675	COG4999	Histidine kinase
HPY09_07680	COG3437	response regulator, receiver
HPY09_07685	COG0625	glutathione transferase activity
HPY09_07695	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY09_07705	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY09_07720	COG3385	transposase activity
HPY09_07740	COG0372	Belongs to the citrate synthase family
HPY09_07745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY09_07770	COG0583	DNA-binding transcription factor activity
HPY09_07775	COG4771	TonB-dependent receptor
HPY09_07820	COG1129	ABC transporter
HPY09_07845	COG0745	RESPONSE REGULATOR receiver
HPY09_07850	COG5002	protein histidine kinase activity
HPY09_07855	COG3713	MltA-interacting MipA family protein
HPY09_07860	COG2990	Protein conserved in bacteria
HPY09_07870	COG4191	Histidine kinase
HPY09_07870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_07875	COG0471	metal ion transport
HPY09_07885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY09_07900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_07910	COG3768	UPF0283 membrane protein
HPY09_07915	COG3106	COG3106 Predicted ATPase
HPY09_07930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY09_07935	COG0494	nUDIX hydrolase
HPY09_07940	COG0814	amino acid
HPY09_07945	COG1760	l-serine dehydratase
HPY09_07950	COG3385	transposase activity
HPY09_07955	COG0720	synthase
HPY09_07965	COG0840	transmembrane signaling receptor activity
HPY09_07970	COG0017	Asparaginyl-tRNA synthetase
HPY09_07975	COG0351	phosphomethylpyrimidine kinase
HPY09_07980	COG2770	Histidine kinase
HPY09_07980	COG3437	response regulator, receiver
HPY09_07985	COG1448	Aminotransferase
HPY09_08000	COG0840	transmembrane signaling receptor activity
HPY09_08005	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY09_08010	COG2943	transferase activity, transferring hexosyl groups
HPY09_08015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY09_08020	COG1846	Transcriptional regulator
HPY09_08045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY09_08060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY09_08065	COG3108	Peptidase M15
HPY09_08100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY09_08110	COG2814	Major facilitator Superfamily
HPY09_08130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY09_08135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY09_08140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY09_08185	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY09_08190	COG4139	cobalamin transport
HPY09_08195	COG2988	succinylglutamate desuccinylase activity
HPY09_08210	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY09_08215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY09_08220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_08230	COG2925	Exonuclease
HPY09_08235	COG1380	Effector of murein hydrolase LrgA
HPY09_08240	COG1346	cytolysis
HPY09_08275	COG0776	regulation of translation
HPY09_08280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_08280	COG0072	phenylalanine-tRNA ligase activity
HPY09_08285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY09_08325	COG0322	excinuclease ABC activity
HPY09_08330	COG2197	response regulator
HPY09_08335	COG0417	DNA replication proofreading
HPY09_08340	COG5001	Diguanylate cyclase
HPY09_08350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY09_08355	COG3099	Belongs to the UPF0263 family
HPY09_08370	COG1228	amidohydrolase
HPY09_08375	COG0010	Belongs to the arginase family
HPY09_08380	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY09_08385	COG2986	histidine ammonia-lyase
HPY09_08405	COG0277	FAD linked oxidase domain protein
HPY09_08405	COG0247	lactate metabolic process
HPY09_08420	COG2885	chlorophyll binding
HPY09_08440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY09_08450	COG0281	malic enzyme
HPY09_08460	COG2949	membrane
HPY09_08465	COG3706	GGDEF domain
HPY09_08470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY09_08480	COG0492	ferredoxin-NADP+ reductase activity
HPY09_08485	COG4988	ABC transporter
HPY09_08490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY09_08495	COG1187	pseudouridine synthase activity
HPY09_08500	COG0009	L-threonylcarbamoyladenylate synthase
HPY09_08505	COG0613	PHP domain protein
HPY09_08515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY09_08520	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY09_08525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY09_08530	COG0134	indole-3-glycerol-phosphate synthase activity
HPY09_08530	COG0135	phosphoribosylanthranilate isomerase activity
HPY09_08535	COG0133	tryptophan synthase activity
HPY09_08540	COG0159	tryptophan synthase activity
HPY09_08550	COG1435	thymidine kinase activity
HPY09_08555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY09_08560	COG1801	Protein of unknown function DUF72
HPY09_08565	COG4106	trans-aconitate 2-methyltransferase activity
HPY09_08570	COG0500	methyltransferase
HPY09_08575	COG4067	protein conserved in archaea
HPY09_08575	COG0189	ligase activity
HPY09_08590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY09_08600	COG3852	Histidine kinase
HPY09_08615	COG3070	regulator of competence-specific genes
HPY09_08625	COG2431	L-lysine efflux transmembrane transporter activity
HPY09_08635	COG0076	glutamate decarboxylase activity
HPY09_08640	COG1737	Transcriptional regulator
HPY09_08645	COG1454	alcohol dehydrogenase
HPY09_08645	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_08650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY09_08655	COG3273	potassium ion transport
HPY09_08655	COG2985	domain, Protein
HPY09_08660	COG0542	response to heat
HPY09_08665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY09_08670	COG1278	Cold shock
HPY09_08680	COG1187	pseudouridine synthase activity
HPY09_08685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY09_08685	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY09_08690	COG0107	imidazoleglycerol-phosphate synthase activity
HPY09_08695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY09_08700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY09_08705	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY09_08705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY09_08710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY09_08715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY09_08720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY09_08725	COG1757	Na H antiporter
HPY09_08730	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY09_08735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_08740	COG0482	sulfurtransferase activity
HPY09_08745	COG2915	High frequency lysogenization protein hflD homolog
HPY09_08750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY09_08760	COG2268	Band 7 protein
HPY09_08770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY09_08795	COG0501	Belongs to the peptidase M48B family
HPY09_08805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY09_08810	COG2226	methyltransferase
HPY09_08815	COG0156	8-amino-7-oxononanoate synthase activity
HPY09_08820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY09_08825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY09_08830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY09_08835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY09_08840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY09_08845	COG0653	protein targeting
HPY09_08850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY09_08855	COG3706	GGDEF domain
HPY09_08865	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY09_08875	COG4628	conserved protein (DUF2132)
HPY09_08880	COG3092	negative regulation of chromosome organization
HPY09_08885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY09_08890	COG0857	belongs to the CobB CobQ family
HPY09_08890	COG0280	phosphate acetyltransferase
HPY09_08895	COG0435	Glutathione S-transferase
HPY09_08900	COG4608	Belongs to the ABC transporter superfamily
HPY09_08905	COG0444	Belongs to the ABC transporter superfamily
HPY09_08910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_08915	COG0601	transmembrane transport
HPY09_08935	COG2204	response regulator
HPY09_08940	COG5001	Diguanylate cyclase
HPY09_08940	COG3300	MHYT domain
HPY09_08945	COG4191	Histidine kinase
HPY09_08950	COG5002	protein histidine kinase activity
HPY09_08960	COG2201	protein-glutamate methylesterase activity
HPY09_08975	COG0009	L-threonylcarbamoyladenylate synthase
HPY09_09000	COG1881	PFAM PEBP family protein
HPY09_09025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY09_09030	COG0640	Transcriptional regulator
HPY09_09040	COG3706	GGDEF domain
HPY09_09060	COG1946	Acyl-CoA thioesterase
HPY09_09065	COG1522	sequence-specific DNA binding
HPY09_09075	COG0616	signal peptide processing
HPY09_09080	COG1028	Short-chain dehydrogenase reductase Sdr
HPY09_09090	COG2983	Belongs to the UPF0260 family
HPY09_09105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY09_09110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY09_09115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY09_09120	COG2832	Protein of unknown function (DUF454)
HPY09_09125	COG0745	RESPONSE REGULATOR receiver
HPY09_09130	COG0583	DNA-binding transcription factor activity
HPY09_09135	COG0778	Nitroreductase
HPY09_09140	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY09_09140	COG1024	Enoyl-CoA hydratase
HPY09_09145	COG0183	Belongs to the thiolase family
HPY09_09160	COG2067	long-chain fatty acid transport protein
HPY09_09165	COG2067	long-chain fatty acid transport protein
HPY09_09170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY09_09175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY09_09180	COG2982	Protein involved in outer membrane biogenesis
HPY09_09185	COG0572	uridine kinase
HPY09_09190	COG0489	protein tyrosine kinase activity
HPY09_09195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_09195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_09205	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY09_09215	COG0517	IMP dehydrogenase activity
HPY09_09215	COG0617	tRNA 3'-terminal CCA addition
HPY09_09215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY09_09220	COG2199	diguanylate cyclase activity
HPY09_09225	COG0314	molybdopterin synthase activity
HPY09_09230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY09_09235	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY09_09240	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY09_09245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY09_09250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY09_09255	COG2198	Histidine kinase
HPY09_09260	COG2204	response regulator
HPY09_09265	COG0556	nucleotide-excision repair
HPY09_09275	COG4657	Part of a membrane complex involved in electron transport
HPY09_09280	COG2878	Part of a membrane complex involved in electron transport
HPY09_09285	COG4656	Part of a membrane complex involved in electron transport
HPY09_09300	COG4660	Part of a membrane complex involved in electron transport
HPY09_09305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY09_09310	COG0346	lactoylglutathione lyase activity
HPY09_09325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY09_09330	COG2056	Na+-H+ antiporter family
HPY09_09335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY09_09340	COG1286	toxin biosynthetic process
HPY09_09345	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY09_09350	COG0285	dihydrofolate synthase activity
HPY09_09355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY09_09360	COG0101	tRNA pseudouridine synthase activity
HPY09_09375	COG2190	(PTS) system
HPY09_09375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_09375	COG1263	PTS System
HPY09_09380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY09_09385	COG1846	Transcriptional regulator
HPY09_09385	COG1940	carbohydrate kinase activity
HPY09_09390	COG4651	solute:proton antiporter activity
HPY09_09390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY09_09410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY09_09415	COG0563	adenylate kinase activity
HPY09_09420	COG0326	Molecular chaperone. Has ATPase activity
HPY09_09425	COG3710	Transcriptional regulator
HPY09_09440	COG0622	Phosphoesterase
HPY09_09445	COG1090	epimerase
HPY09_09450	COG0300	oxidoreductase activity
HPY09_09455	COG3118	belongs to the thioredoxin family
HPY09_09460	COG0330	HflC and HflK could
HPY09_09465	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY09_09470	COG0789	Transcriptional regulator
HPY09_09485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY09_09490	COG3115	cell septum assembly
HPY09_09495	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY09_09500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY09_09505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_09515	COG2190	(PTS) system
HPY09_09520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_09525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY09_09530	COG1702	phosphate starvation-inducible protein PhoH
HPY09_09535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY09_09540	COG4535	Mg2 and Co2 transporter CorC
HPY09_09545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY09_09550	COG2888	peptidyl-tyrosine sulfation
HPY09_09555	COG0495	leucyl-tRNA aminoacylation
HPY09_09560	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY09_09565	COG1466	dna polymerase III delta subunit
HPY09_09570	COG0799	negative regulation of ribosome biogenesis
HPY09_09575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY09_09580	COG0768	penicillin binding
HPY09_09585	COG0772	Belongs to the SEDS family
HPY09_09590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY09_09595	COG1686	Belongs to the peptidase S11 family
HPY09_09600	COG2921	Belongs to the UPF0250 family
HPY09_09605	COG0321	lipoyl(octanoyl) transferase activity
HPY09_09610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY09_09620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY09_09645	COG1596	polysaccharide export
HPY09_09655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY09_09685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY09_09695	COG0438	transferase activity, transferring glycosyl groups
HPY09_09705	COG1045	serine acetyltransferase
HPY09_09725	COG0110	maltose O-acetyltransferase activity
HPY09_09730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY09_09735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY09_09740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY09_09745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY09_09775	COG0366	Alpha amylase catalytic
HPY09_09780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_09780	COG1263	PTS System
HPY09_09785	COG1609	Transcriptional regulator
HPY09_09790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY09_09795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY09_09800	COG2011	ABC-type metal ion transport system permease component
HPY09_09805	COG1464	Belongs to the NlpA lipoprotein family
HPY09_09810	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY09_09820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY09_09820	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY09_09830	COG3706	GGDEF domain
HPY09_09835	COG1611	Belongs to the LOG family
HPY09_09840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY09_09845	COG2363	Small membrane protein
HPY09_09850	COG0583	DNA-binding transcription factor activity
HPY09_09855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY09_09855	COG0301	tRNA thio-modification
HPY09_09865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY09_09870	COG1722	exodeoxyribonuclease VII activity
HPY09_09875	COG0142	geranyltranstransferase activity
HPY09_09880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY09_09885	COG0564	pseudouridine synthase activity
HPY09_09890	COG3098	single-species biofilm formation
HPY09_09905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_09915	COG1671	Belongs to the UPF0178 family
HPY09_09920	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY09_09925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY09_09930	COG0254	rRNA binding
HPY09_09935	COG1720	tRNA m6t6A37 methyltransferase activity
HPY09_09940	COG0442	prolyl-tRNA aminoacylation
HPY09_09960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY09_09960	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY09_09970	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY09_09980	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY09_10010	COG0484	heat shock protein binding
HPY09_10020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY09_10025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY09_10030	COG0497	DNA recombination
HPY09_10035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_10040	COG2914	Belongs to the UPF0125 (RnfH) family
HPY09_10045	COG2867	negative regulation of translational initiation
HPY09_10050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY09_10080	COG1104	cysteine desulfurase activity
HPY09_10145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY09_10150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY09_10155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY09_10175	COG3051	citrate lyase alpha subunit
HPY09_10180	COG2301	Belongs to the HpcH HpaI aldolase family
HPY09_10190	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY09_10205	COG5016	pyruvate
HPY09_10205	COG0511	ligase activity, forming carbon-carbon bonds
HPY09_10210	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY09_10220	COG4565	transcriptional regulatory protein
HPY09_10245	COG1115	amino acid carrier protein
HPY09_10250	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY09_10255	COG0583	DNA-binding transcription factor activity
HPY09_10265	COG1120	ATPase activity
HPY09_10270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_10275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_10280	COG4592	Periplasmic binding protein
HPY09_10290	COG1028	Short-chain dehydrogenase reductase Sdr
HPY09_10295	COG1169	isochorismate synthase
HPY09_10300	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY09_10305	COG3433	isochorismatase activity
HPY09_10305	COG1535	isochorismatase
HPY09_10310	COG1584	GPR1 FUN34 yaaH family protein
HPY09_10320	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY09_10330	COG0519	Catalyzes the synthesis of GMP from XMP
HPY09_10330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY09_10335	COG0516	GMP reductase activity
HPY09_10335	COG0517	IMP dehydrogenase activity
HPY09_10340	COG1570	exodeoxyribonuclease VII activity
HPY09_10355	COG1160	GTP binding
HPY09_10360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_10365	COG2976	Protein conserved in bacteria
HPY09_10370	COG0124	histidyl-tRNA synthetase
HPY09_10375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY09_10385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPY09_10390	COG0105	UTP biosynthetic process
HPY09_10400	COG2975	iron-sulfur cluster assembly
HPY09_10405	COG0633	Ferredoxin
HPY09_10425	COG0822	iron-sulfur transferase activity
HPY09_10435	COG1959	2 iron, 2 sulfur cluster binding
HPY09_10445	COG0483	inositol monophosphate 1-phosphatase activity
HPY09_10450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_10455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_10460	COG1862	Preprotein translocase
HPY09_10470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY09_10475	COG0517	IMP dehydrogenase activity
HPY09_10485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY09_10490	COG0583	DNA-binding transcription factor activity
HPY09_10495	COG0450	alkyl hydroperoxide reductase
HPY09_10500	COG3142	Participates in the control of copper homeostasis
HPY09_10515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY09_10520	COG0581	inorganic phosphate transmembrane transporter activity
HPY09_10530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY09_10535	COG0248	Ppx GppA phosphatase
HPY09_10545	COG5002	protein histidine kinase activity
HPY09_10550	COG0745	RESPONSE REGULATOR receiver
HPY09_10565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY09_10610	COG0542	response to heat
HPY09_10620	COG0564	pseudouridine synthase activity
HPY09_10625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_10630	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY09_10635	COG1605	Chorismate mutase
HPY09_10635	COG0077	Prephenate dehydratase
HPY09_10640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY09_10645	COG5001	Diguanylate cyclase
HPY09_10655	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY09_10665	COG0488	(ABC) transporter
HPY09_10675	COG0287	Prephenate dehydrogenase
HPY09_10675	COG1605	Chorismate mutase
HPY09_10680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY09_10685	COG3275	phosphorelay sensor kinase activity
HPY09_10690	COG3279	Response regulator of the LytR AlgR family
HPY09_10700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY09_10705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY09_10720	COG1966	Carbon starvation protein
HPY09_10725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY09_10730	COG1047	Peptidyl-prolyl cis-trans
HPY09_10735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY09_10745	COG0196	riboflavin kinase activity
HPY09_10750	COG0728	peptidoglycan biosynthetic process
HPY09_10755	COG0268	Binds directly to 16S ribosomal RNA
HPY09_10760	COG0640	Transcriptional regulator
HPY09_10765	COG0583	DNA-binding transcription factor activity
HPY09_10770	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY09_10775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPY09_10780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY09_10785	COG0730	response to heat
HPY09_10790	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY09_10795	COG0494	nUDIX hydrolase
HPY09_10800	COG3066	DNA modification
HPY09_10805	COG0667	Aldo Keto reductase
HPY09_10815	COG2204	response regulator
HPY09_10820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY09_10840	COG0513	Belongs to the DEAD box helicase family
HPY09_10865	COG3153	acetyltransferase
HPY09_10870	COG3154	lipid carrier protein
HPY09_10880	COG0826	peptidase U32
HPY09_10885	COG0826	peptidase U32
HPY09_10910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY09_10920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY09_10925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY09_10930	COG0195	Participates in both transcription termination and antitermination
HPY09_10935	COG0779	Required for maturation of 30S ribosomal subunits
HPY09_10950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY09_10960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY09_10965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY09_10970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY09_10975	COG1534	Rna-binding protein
HPY09_10980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY09_10985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY09_10990	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY09_10995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY09_11000	COG0739	heme binding
HPY09_11015	COG0316	Belongs to the HesB IscA family
HPY09_11020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY09_11025	COG0628	permease
HPY09_11030	COG2813	Specifically methylates the guanine in position
HPY09_11035	COG0784	Response regulator, receiver
HPY09_11035	COG2205	protein histidine kinase activity
HPY09_11040	COG0747	negative chemotaxis
HPY09_11050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_11055	COG0444	Belongs to the ABC transporter superfamily
HPY09_11060	COG4608	Belongs to the ABC transporter superfamily
HPY09_11070	COG2971	BadF BadG BcrA BcrD
HPY09_11090	COG3842	ATPase activity
HPY09_11100	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY09_11105	COG0004	ammonium transporteR
HPY09_11110	COG0347	Belongs to the P(II) protein family
HPY09_11115	COG3112	Uncharacterised protein family (UPF0231)
HPY09_11120	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY09_11125	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY09_11130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY09_11135	COG1643	Atp-dependent helicase
HPY09_11145	COG1489	DNA binding
HPY09_11155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY09_11165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY09_11170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY09_11175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY09_11180	COG0842	Transport permease protein
HPY09_11185	COG1131	(ABC) transporter
HPY09_11190	COG0659	secondary active sulfate transmembrane transporter activity
HPY09_11195	COG0288	reversible hydration of carbon dioxide
HPY09_11210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY09_11215	COG3107	peptidoglycan biosynthetic process
HPY09_11220	COG0792	nuclease activity
HPY09_11225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY09_11230	COG2823	Periplasmic or secreted lipoprotein
HPY09_11235	COG2969	positive regulation of protein catabolic process
HPY09_11240	COG0625	glutathione transferase activity
HPY09_11245	COG2857	Cytochrome c1
HPY09_11250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY09_11255	COG0723	plastoquinol--plastocyanin reductase activity
HPY09_11260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY09_11265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY09_11270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY09_11280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY09_11285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY09_11290	COG0335	large ribosomal subunit rRNA binding
HPY09_11295	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY09_11300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY09_11305	COG0228	four-way junction DNA binding
HPY09_11310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY09_11315	COG4137	Cytochrome C assembly protein
HPY09_11320	COG4536	flavin adenine dinucleotide binding
HPY09_11325	COG1854	S-ribosylhomocysteine lyase activity
HPY09_11330	COG2918	glutathione biosynthetic process
HPY09_11335	COG0612	Peptidase, M16
HPY09_11340	COG1238	metal cluster binding
HPY09_11350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY09_11355	COG5016	pyruvate
HPY09_11355	COG0511	ligase activity, forming carbon-carbon bonds
HPY09_11360	COG3630	sodium ion export across plasma membrane
HPY09_11405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY09_11415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY09_11425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY09_11435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY09_11440	COG4208	sulfate ABC transporter
HPY09_11460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY09_11465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY09_11475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY09_11480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY09_11485	COG0585	pseudouridine synthase activity
HPY09_11490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY09_11495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY09_11500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY09_11505	COG1968	undecaprenyl-diphosphatase activity
HPY09_11510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY09_11515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY09_11520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY09_11530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY09_11535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY09_11540	COG1610	YqeY-like protein
HPY09_11545	COG0358	DNA primase activity
HPY09_11565	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY09_11570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY09_11575	COG1349	DNA-binding transcription factor activity
HPY09_11595	COG1279	arginine transmembrane transporter activity
HPY09_11600	COG0668	transmembrane transport
HPY09_11610	COG0126	phosphoglycerate kinase activity
HPY09_11615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY09_11620	COG4771	TonB-dependent receptor
HPY09_11625	COG0583	DNA-binding transcription factor activity
HPY09_11630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY09_11635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY09_11645	COG2356	endonuclease I
HPY09_11655	COG0189	ligase activity
HPY09_11660	COG1678	Uncharacterized ACR, COG1678
HPY09_11665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY09_11670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY09_11690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY09_11695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY09_11700	COG0762	integral membrane protein
HPY09_11705	COG1872	DUF167
HPY09_11715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY09_11720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY09_11725	COG2066	Belongs to the glutaminase family
HPY09_11730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY09_11735	COG1194	a g-specific adenine glycosylase
HPY09_11740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY09_11745	COG0741	lytic transglycosylase activity
HPY09_11800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY09_11805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY09_11810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY09_11815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY09_11820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY09_11825	COG2967	ApaG domain
HPY09_11830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY09_11840	COG3610	response to peptide
HPY09_11845	COG2966	Psort location CytoplasmicMembrane, score
HPY09_11850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY09_11855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY09_11860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY09_11865	COG0142	geranyltranstransferase activity
HPY09_11870	COG0531	amino acid
HPY09_11875	COG0039	L-malate dehydrogenase activity
HPY09_11880	COG1438	arginine binding
HPY09_11885	COG2358	TRAP transporter, solute receptor (TAXI family
HPY09_11895	COG0589	response to stress
HPY09_11915	COG2235	arginine
HPY09_11920	COG0312	modulator of DNA gyrase
HPY09_11925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY09_11930	COG3164	Protein of unknown function
HPY09_11935	COG1530	ribonuclease E activity
HPY09_11940	COG0424	maF-like protein
HPY09_11945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY09_11950	COG1792	Involved in formation and maintenance of cell shape
HPY09_11955	COG1077	Cell shape determining protein MreB Mrl
HPY09_12000	COG1459	type II secretion system
HPY09_12005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY09_12015	COG3409	Peptidoglycan-binding domain 1 protein
HPY09_12015	COG3267	Type II secretory pathway component ExeA
HPY09_12040	COG2199	diguanylate cyclase activity
HPY09_12040	COG2200	EAL domain
HPY09_12045	COG0629	single-stranded DNA binding
HPY09_12060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY09_12070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY09_12075	COG0527	aspartate kinase activity
HPY09_12080	COG1410	methionine synthase
HPY09_12080	COG0646	methionine synthase
HPY09_12120	COG0175	sulfate reduction
HPY09_12130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY09_12155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY09_12160	COG0735	belongs to the Fur family
HPY09_12175	COG0166	Belongs to the GPI family
HPY09_12180	COG0432	Pfam Uncharacterised protein family UPF0047
HPY09_12185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY09_12200	COG0359	binds to the 23S rRNA
HPY09_12205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY09_12210	COG2965	DNA replication, synthesis of RNA primer
HPY09_12215	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY09_12225	COG2906	2 iron, 2 sulfur cluster binding
HPY09_12230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY09_12235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY09_12240	COG0049	tRNA binding
HPY09_12255	COG2923	Belongs to the DsrF TusC family
HPY09_12260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY09_12265	COG2964	Protein conserved in bacteria
HPY09_12270	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY09_12280	COG2900	Belongs to the SlyX family
HPY09_12285	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY09_12290	COG0330	HflC and HflK could
HPY09_12295	COG0330	HflC and HflK could
HPY09_12300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY09_12305	COG1923	regulation of RNA biosynthetic process
HPY09_12310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY09_12315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY09_12325	COG0802	atpase or kinase
HPY09_12330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY09_12380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY09_12385	COG1162	GTPase activity
HPY09_12390	COG0688	phosphatidylethanolamine metabolic process
HPY09_12395	COG0471	metal ion transport
HPY09_12405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY09_12410	COG4942	peptidase
HPY09_12425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY09_12430	COG2816	NAD+ diphosphatase activity
HPY09_12435	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY09_12440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY09_12445	COG0085	RNA polymerase activity
HPY09_12450	COG0222	ribosome binding
HPY09_12455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY09_12465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY09_12470	COG0250	Participates in transcription elongation, termination and antitermination
HPY09_12475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY09_12480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY09_12505	COG1072	(Pantothenic acid kinase))
HPY09_12515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY09_12525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY09_12605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY09_12620	COG3118	belongs to the thioredoxin family
HPY09_12625	COG0513	Belongs to the DEAD box helicase family
HPY09_12630	COG0248	Ppx GppA phosphatase
HPY09_12635	COG0784	Response regulator, receiver
HPY09_12635	COG2205	protein histidine kinase activity
HPY09_12640	COG2814	Major facilitator Superfamily
HPY09_12660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY09_12665	COG0511	ligase activity, forming carbon-carbon bonds
HPY09_12670	COG0439	Biotin carboxylase
HPY09_12675	COG2264	protein methyltransferase activity
HPY09_12680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY09_12685	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY09_12690	COG1609	Transcriptional regulator
HPY09_12700	COG0387	Pfam Sodium calcium exchanger
HPY09_12705	COG0129	dihydroxy-acid dehydratase activity
HPY09_12710	COG3265	gluconokinase activity
HPY09_12720	COG0800	Aldolase
HPY09_12740	COG0840	transmembrane signaling receptor activity
HPY09_12750	COG0531	amino acid
HPY09_12755	COG3710	Transcriptional regulator
HPY09_12760	COG0789	Transcriptional regulator
HPY09_12775	COG0151	Belongs to the GarS family
HPY09_12785	COG0776	regulation of translation
HPY09_12790	COG1253	flavin adenine dinucleotide binding
HPY09_12795	COG3068	Protein conserved in bacteria
HPY09_12805	COG1573	uracil-dna glycosylase
HPY09_12810	COG0668	transmembrane transport
HPY09_12815	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY09_12820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY09_12830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY09_12870	COG0517	IMP dehydrogenase activity
HPY09_12870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY09_12880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY09_12900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_12915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY09_12970	COG1086	Polysaccharide biosynthesis protein
HPY09_12975	COG0438	transferase activity, transferring glycosyl groups
HPY09_13005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY09_13030	COG0859	PFAM glycosyl transferase family 9
HPY09_13040	COG1519	Transferase
HPY09_13065	COG3642	lipopolysaccharide core region biosynthetic process
HPY09_13070	COG0859	PFAM glycosyl transferase family 9
HPY09_13075	COG0463	Glycosyl transferase, family 2
HPY09_13080	COG0859	PFAM glycosyl transferase family 9
HPY09_13085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY09_13090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY09_13100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY09_13105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY09_13110	COG2003	Belongs to the UPF0758 family
HPY09_13120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY09_13130	COG1309	transcriptional regulator
HPY09_13135	COG1560	Kdo2-lipid A biosynthetic process
HPY09_13140	COG1560	Kdo2-lipid A biosynthetic process
HPY09_13145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY09_13150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY09_13155	COG1561	YicC-like family, N-terminal region
HPY09_13160	COG2862	Uncharacterized protein family, UPF0114
HPY09_13165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY09_13170	COG1263	PTS System
HPY09_13170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_13175	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY09_13190	COG0514	ATP-dependent DNA helicase (RecQ)
HPY09_13195	COG2962	Rard protein
HPY09_13200	COG0405	Gamma-glutamyltransferase
HPY09_13210	COG1280	lysine exporter protein (LysE YggA)
HPY09_13215	COG0210	DNA helicase
HPY09_13225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY09_13230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_13240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_13250	COG0747	negative chemotaxis
HPY09_13300	COG1309	transcriptional regulator
HPY09_13305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_13310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY09_13315	COG2960	long-chain fatty acid transporting porin activity
HPY09_13320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY09_13325	COG0583	DNA-binding transcription factor activity
HPY09_13395	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY09_13400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY09_13405	COG1739	Uncharacterized protein family UPF0029
HPY09_13410	COG1024	Enoyl-CoA hydratase
HPY09_13410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY09_13415	COG0183	Belongs to the thiolase family
HPY09_13420	COG0583	DNA-binding transcription factor activity
HPY09_13425	COG2814	Major facilitator Superfamily
HPY09_13435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY09_13440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY09_13445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY09_13450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY09_13455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY09_13460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY09_13470	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY09_13475	COG3312	ion transport
HPY09_13480	COG1475	DNA binding
HPY09_13485	COG1192	Involved in chromosome partitioning
HPY09_13490	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY09_13495	COG0445	tRNA wobble uridine modification
HPY09_13500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY09_13505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY09_13510	COG0706	membrane insertase activity
HPY09_13520	COG0594	ribonuclease P activity
HPY09_13525	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY09_13530	COG1126	abc transporter atp-binding protein
HPY09_13575	COG0217	transcriptional regulatory protein
HPY09_13580	COG2084	Dehydrogenase
HPY09_13595	COG2909	trisaccharide binding
HPY09_13600	COG0058	SHG alpha-glucan phosphorylase activity
HPY09_13610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY09_13620	COG3501	Rhs element vgr protein
HPY09_13655	COG0471	metal ion transport
HPY09_13660	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY09_13690	COG0671	phosphoesterase, PA-phosphatase related
HPY09_13700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY09_13710	COG1999	signal sequence binding
HPY09_13725	COG0786	glutamate:sodium symporter activity
HPY09_13745	COG1566	PFAM secretion protein HlyD family protein
HPY09_13755	COG3706	GGDEF domain
HPY09_13770	COG0813	purine-nucleoside phosphorylase activity
HPY09_13775	COG3272	Protein of unknown function (DUF1722)
HPY09_13785	COG0415	Belongs to the DNA photolyase family
HPY09_13790	COG1388	LysM domain
HPY09_13790	COG1376	ErfK ybiS ycfS ynhG family protein
HPY09_13800	COG0513	Belongs to the DEAD box helicase family
HPY09_13805	COG1770	oligopeptidase
HPY09_13835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY09_13840	COG0573	inorganic phosphate transmembrane transporter activity
HPY09_13845	COG0581	inorganic phosphate transmembrane transporter activity
HPY09_13850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY09_13870	COG0659	secondary active sulfate transmembrane transporter activity
HPY09_13880	COG0739	heme binding
HPY09_13885	COG3300	MHYT domain
HPY09_13885	COG5001	Diguanylate cyclase
HPY09_13890	COG0583	DNA-binding transcription factor activity
HPY09_13895	COG2814	Major facilitator Superfamily
HPY09_13915	COG1301	dicarboxylic acid transport
HPY09_13930	COG1342	Belongs to the UPF0251 family
HPY09_13965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY09_13970	COG0673	inositol 2-dehydrogenase activity
HPY09_13980	COG2771	luxR family
HPY09_13980	COG2200	EAL domain
HPY09_13985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY09_13995	COG0564	pseudouridine synthase activity
HPY09_14100	COG1869	D-ribose catabolic process
HPY09_14105	COG1129	ABC transporter
HPY09_14110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY09_14115	COG1879	ABC-type sugar transport system periplasmic component
HPY09_14120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_14125	COG1609	Transcriptional regulator
HPY09_14135	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY09_14155	COG0584	glycerophosphoryl diester phosphodiesterase
HPY09_14160	COG2271	Major facilitator Superfamily
HPY09_14195	COG0579	oxidoreductase
HPY09_14205	COG0242	peptide deformylase activity
HPY09_14210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY09_14210	COG1017	nitric oxide dioxygenase activity
HPY09_14215	COG1320	monovalent cation:proton antiporter activity
HPY09_14240	COG2111	Na H antiporter
HPY09_14240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY09_14250	COG0589	response to stress
HPY09_14255	COG0814	amino acid
HPY09_14270	COG3530	Putative quorum-sensing-regulated virulence factor
HPY09_14280	COG5001	Diguanylate cyclase
HPY09_14280	COG5002	protein histidine kinase activity
HPY09_14285	COG1278	Cold shock
HPY09_14300	COG2304	oxidoreductase activity
HPY09_14320	COG0714	Associated with various cellular activities
HPY09_14325	COG0840	transmembrane signaling receptor activity
HPY09_14340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY09_14345	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY09_14355	COG3604	Transcriptional regulator
HPY09_14360	COG1017	nitric oxide dioxygenase activity
HPY09_14360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY09_14365	COG1278	Cold shock
HPY09_14370	COG3036	rescue of stalled ribosome
HPY09_14395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY09_14395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY09_14400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY09_14410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY09_14420	COG0516	GMP reductase activity
HPY09_14445	COG0513	Belongs to the DEAD box helicase family
HPY09_14450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY09_14455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY09_14465	COG0784	Response regulator, receiver
HPY09_14465	COG3437	response regulator, receiver
HPY09_14475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_14475	COG4191	Histidine kinase
HPY09_14485	COG1757	Na H antiporter
HPY09_14490	COG2814	Major facilitator Superfamily
HPY09_14500	COG3706	GGDEF domain
HPY09_14505	COG3240	lipase activity
HPY09_14515	COG0840	transmembrane signaling receptor activity
HPY09_14520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY09_14525	COG5380	lipid catabolic process
HPY09_14550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_14555	COG4605	iron ion homeostasis
HPY09_14560	COG4604	ABC transporter, ATP-binding protein
HPY09_14565	COG2207	Transcriptional regulator
HPY09_14580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY09_14585	COG0640	Transcriptional regulator
HPY09_14590	COG0798	PFAM Bile acid sodium symporter
HPY09_14610	COG0583	DNA-binding transcription factor activity
HPY09_14625	COG0745	RESPONSE REGULATOR receiver
HPY09_14655	COG3623	hexulose-6-phosphate isomerase
HPY09_14660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY09_14665	COG0561	phosphatase activity
HPY09_14710	COG1335	isochorismatase
HPY09_14715	COG1741	Belongs to the pirin family
HPY09_14720	COG0583	DNA-binding transcription factor activity
HPY09_14725	COG0366	Alpha amylase catalytic
HPY09_14745	COG0745	RESPONSE REGULATOR receiver
HPY09_14750	COG5002	protein histidine kinase activity
HPY09_14770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY09_14785	COG0583	DNA-binding transcription factor activity
HPY09_14800	COG1686	Belongs to the peptidase S11 family
HPY09_14820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY09_14820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY09_14825	COG0509	glycine decarboxylation via glycine cleavage system
HPY09_14830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY09_14855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY09_14860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY09_14870	COG4977	sequence-specific DNA binding
HPY09_14940	COG0346	lactoylglutathione lyase activity
HPY09_14975	COG0384	phenazine biosynthesis protein PhzF
HPY09_15035	COG0384	phenazine biosynthesis protein PhzF
HPY09_15070	COG0456	acetyltransferase
HPY09_15100	COG0384	phenazine biosynthesis protein PhzF
HPY09_15250	COG2801	Transposase and inactivated derivatives
HPY09_15400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY09_15545	COG0346	lactoylglutathione lyase activity
HPY09_15555	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY09_15605	COG0456	acetyltransferase
HPY09_15665	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY09_15875	COG3041	Addiction module toxin RelE StbE family
HPY09_15935	COG1418	mRNA catabolic process
HPY09_15960	COG0456	acetyltransferase
HPY09_15975	COG3549	Plasmid maintenance system killer
HPY09_15980	COG3093	addiction module antidote protein HigA
HPY09_16040	COG0456	acetyltransferase
HPY09_16045	COG4977	sequence-specific DNA binding
HPY09_16075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_16075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_16160	COG1714	RDD family
HPY09_16290	COG2357	RelA SpoT domain protein
HPY09_16610	COG0346	lactoylglutathione lyase activity
HPY09_16695	COG5642	Protein of unknown function (DUF2384)
HPY09_16715	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY09_16730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY09_16735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_16740	COG1621	beta-fructofuranosidase activity
HPY09_16750	COG1263	PTS System
HPY09_16750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_16790	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY09_16830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY09_16835	COG0583	DNA-binding transcription factor activity
HPY09_16860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY09_16885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY09_16895	COG2390	Transcriptional regulator
HPY09_16900	COG2897	thiosulfate sulfurtransferase activity
HPY09_16910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY09_16920	COG0302	gtp cyclohydrolase
HPY09_16925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_16925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_16930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY09_16935	COG1970	mechanosensitive ion channel activity
HPY09_16940	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY09_16955	COG1011	Hydrolase
HPY09_16960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY09_16965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY09_16975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY09_16980	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY09_16985	COG3842	ATPase activity
HPY09_17005	COG3104	oligopeptide transport
HPY09_17030	COG4166	transmembrane transport
HPY09_17035	COG4174	ABC transporter (Permease)
HPY09_17040	COG4239	(ABC) transporter, permease
HPY09_17045	COG4172	Belongs to the ABC transporter superfamily
HPY09_17050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY09_17065	COG0625	glutathione transferase activity
HPY09_17085	COG2050	protein possibly involved in aromatic compounds catabolism
HPY09_17100	COG4771	TonB-dependent receptor
HPY09_17105	COG0583	DNA-binding transcription factor activity
HPY09_17110	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY09_17110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_17110	COG1042	CoA-binding domain protein
HPY09_17130	COG0023	Translation Initiation Factor
HPY09_17135	COG3140	Belongs to the UPF0181 family
HPY09_17150	COG0745	RESPONSE REGULATOR receiver
HPY09_17160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY09_17165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY09_17180	COG3706	GGDEF domain
HPY09_17230	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY09_17245	COG0737	Belongs to the 5'-nucleotidase family
HPY09_17250	COG3593	DNA synthesis involved in DNA repair
HPY09_17260	COG0583	DNA-binding transcription factor activity
HPY09_17265	COG2116	formate transmembrane transporter activity
HPY09_17275	COG3038	cytochrome b561
HPY09_17285	COG2200	EAL domain
HPY09_17300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY09_17310	COG2205	protein histidine kinase activity
HPY09_17315	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY09_17315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY09_17315	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY09_17315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY09_17320	COG3158	transport of potassium into the cell
HPY09_17330	COG0523	cobalamin synthesis protein
HPY09_17335	COG0038	chloride channel
HPY09_17345	COG0156	8-amino-7-oxononanoate synthase activity
HPY09_17350	COG0784	Response regulator, receiver
HPY09_17350	COG2205	protein histidine kinase activity
HPY09_17355	COG0419	ATPase involved in DNA repair
HPY09_17360	COG0420	3'-5' exonuclease activity
HPY09_17365	COG1609	Transcriptional regulator
HPY09_17370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_17370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_17375	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY09_17380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY09_17380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_17380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_17385	COG0189	ligase activity
HPY09_17385	COG4067	protein conserved in archaea
HPY09_17395	COG0602	queuosine metabolic process
HPY09_17400	COG1328	CTP reductase activity
HPY09_17410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY09_17415	COG0840	transmembrane signaling receptor activity
HPY09_17420	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY09_17425	COG1760	l-serine dehydratase
HPY09_17430	COG2197	response regulator
HPY09_17435	COG3850	Histidine kinase
HPY09_17440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY09_17450	COG0243	molybdopterin cofactor binding
HPY09_17470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY09_17475	COG2197	response regulator
HPY09_17480	COG3851	Histidine kinase
HPY09_17485	COG2271	Major facilitator Superfamily
HPY09_17490	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY09_17500	COG3842	ATPase activity
HPY09_17505	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY09_17515	COG0183	Belongs to the thiolase family
HPY09_17525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_17530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_17545	COG3706	GGDEF domain
HPY09_17550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY09_17560	COG1979	alcohol dehydrogenase
HPY09_17575	COG4191	Histidine kinase
HPY09_17585	COG2271	Major facilitator Superfamily
HPY09_17590	COG0469	pyruvate kinase activity
HPY09_17600	COG1879	ABC-type sugar transport system periplasmic component
HPY09_17605	COG1803	Methylglyoxal synthase
HPY09_17610	COG1335	isochorismatase
HPY09_17615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY09_17620	COG0210	DNA helicase
HPY09_17625	COG1289	transmembrane transporter activity
HPY09_17655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY09_17660	COG4149	molybdate abc transporter
HPY09_17665	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY09_17670	COG1492	cobalamin metabolic process
HPY09_17710	COG4977	sequence-specific DNA binding
HPY09_17710	COG1917	Cupin 2, conserved barrel domain protein
HPY09_17715	COG4771	TonB-dependent receptor
HPY09_17720	COG2814	Major facilitator Superfamily
HPY09_17725	COG2226	methyltransferase
HPY09_17725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY09_17725	COG3433	isochorismatase activity
HPY09_17750	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY09_17755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY09_17775	COG1132	(ABC) transporter
HPY09_17780	COG1132	(ABC) transporter
HPY09_17790	COG5002	protein histidine kinase activity
HPY09_17790	COG0784	Response regulator, receiver
HPY09_17795	COG1879	ABC-type sugar transport system periplasmic component
HPY09_17805	COG2827	Endonuclease containing a URI domain
HPY09_17820	COG2926	Belongs to the UPF0265 family
HPY09_17835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY09_17840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY09_17850	COG0247	lactate metabolic process
HPY09_17855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY09_17860	COG3118	belongs to the thioredoxin family
HPY09_17885	COG4160	amino acid transport
HPY09_17890	COG4215	(ABC) transporter
HPY09_17895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_17900	COG1126	abc transporter atp-binding protein
HPY09_17910	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY09_17920	COG0494	nUDIX hydrolase
HPY09_17925	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY09_17935	COG1309	transcriptional regulator
HPY09_17940	COG0513	Belongs to the DEAD box helicase family
HPY09_17945	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY09_17950	COG0814	amino acid
HPY09_17955	COG0840	transmembrane signaling receptor activity
HPY09_17960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY09_17965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY09_17975	COG1984	allophanate hydrolase subunit 2
HPY09_17990	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY09_17995	COG4181	ATPase activity
HPY09_18005	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY09_18010	COG5001	Diguanylate cyclase
HPY09_18010	COG1716	ATPase activity
HPY09_18020	COG0484	heat shock protein binding
HPY09_18035	COG0546	phosphoglycolate phosphatase activity
HPY09_18050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_18055	COG1368	sulfuric ester hydrolase activity
HPY09_18065	COG0513	Belongs to the DEAD box helicase family
HPY09_18080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY09_18090	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY09_18095	COG3397	chitin binding
HPY09_18100	COG3227	Zinc metalloprotease (Elastase)
HPY09_18110	COG0010	Belongs to the arginase family
HPY09_18115	COG1166	arginine decarboxylase activity
HPY09_18125	COG2239	Acts as a magnesium transporter
HPY09_18130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY09_18135	COG0459	protein refolding
HPY09_18145	COG0527	aspartate kinase activity
HPY09_18150	COG0662	Cupin 2, conserved barrel domain protein
HPY09_18155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY09_18160	COG0456	acetyltransferase
HPY09_18165	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY09_18170	COG3186	Phenylalanine-4-hydroxylase
HPY09_18175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY09_18190	COG2264	protein methyltransferase activity
HPY09_18215	COG1253	flavin adenine dinucleotide binding
HPY09_18220	COG1765	OsmC-like protein
HPY09_18250	COG1252	NADH dehydrogenase
HPY09_18255	COG0531	amino acid
HPY09_18260	COG3706	GGDEF domain
HPY09_18270	COG3279	Response regulator of the LytR AlgR family
HPY09_18275	COG3275	phosphorelay sensor kinase activity
HPY09_18290	COG1136	(ABC) transporter
HPY09_18290	COG0577	efflux transmembrane transporter activity
HPY09_18295	COG1136	(ABC) transporter
HPY09_18305	COG4989	oxidoreductase activity
HPY09_18310	COG0366	Alpha amylase catalytic
HPY09_18320	COG2067	long-chain fatty acid transport protein
HPY09_18325	COG2267	carboxylic ester hydrolase activity
HPY09_18335	COG3227	Zinc metalloprotease (Elastase)
HPY09_18340	COG3047	cAMP biosynthetic process
HPY09_18350	COG1686	Belongs to the peptidase S11 family
HPY09_18360	COG1278	Cold shock
HPY09_18370	COG3048	D-serine ammonia-lyase activity
HPY09_18400	COG2801	Transposase and inactivated derivatives
HPY09_18405	COG5002	protein histidine kinase activity
HPY09_18425	COG0582	viral genome integration into host DNA
HPY09_18445	COG1063	alcohol dehydrogenase
HPY09_18470	COG0346	lactoylglutathione lyase activity
HPY09_18490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY09_18495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY09_18500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY09_18510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY09_18535	COG1929	Belongs to the glycerate kinase type-1 family
HPY09_18540	COG2610	gluconate transmembrane transporter activity
HPY09_18545	COG3835	regulator
HPY09_18555	COG0748	coenzyme F420 binding
HPY09_18560	COG3721	Heme iron utilization protein
HPY09_18570	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY09_18575	COG0811	peptide transport
HPY09_18580	COG0848	biopolymer transport protein
HPY09_18585	COG4558	Periplasmic binding protein
HPY09_18590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_18595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY09_18630	COG3217	Mosc domain protein beta barrel domain protein
HPY09_18630	COG0633	Ferredoxin
HPY09_18630	COG0633	Ferredoxin
HPY09_18630	COG3217	Mosc domain protein beta barrel domain protein
HPY09_18635	COG0418	dihydroorotase activity
HPY09_18640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY09_18645	COG2354	Protein conserved in bacteria
HPY09_18655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY09_18660	COG1278	Cold shock
HPY09_18685	COG3706	GGDEF domain
HPY09_18690	COG1349	DNA-binding transcription factor activity
HPY09_18705	COG3833	ABC-type maltose transport systems, permease component
HPY09_18710	COG1175	transmembrane transport
HPY09_18720	COG3842	ATPase activity
HPY09_18725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_18740	COG0393	Putative heavy-metal-binding
HPY09_18750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY09_18755	COG0835	chemotaxis
HPY09_18755	COG0784	Response regulator, receiver
HPY09_18760	COG1846	Transcriptional regulator
HPY09_18765	COG3706	GGDEF domain
HPY09_18800	COG0583	DNA-binding transcription factor activity
HPY09_18805	COG5001	Diguanylate cyclase
HPY09_18815	COG1741	Belongs to the pirin family
HPY09_18820	COG3123	guanosine phosphorylase activity
HPY09_18830	COG2211	Major facilitator Superfamily
HPY09_18835	COG0840	transmembrane signaling receptor activity
HPY09_18840	COG1067	ATP-dependent peptidase activity
HPY09_18850	COG4172	Belongs to the ABC transporter superfamily
HPY09_18870	COG0583	DNA-binding transcription factor activity
HPY09_18880	COG1620	l-lactate permease
HPY09_18895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY09_18905	COG0840	transmembrane signaling receptor activity
HPY09_18925	COG2258	MOSC domain
HPY09_18930	COG0513	Belongs to the DEAD box helicase family
HPY09_18940	COG1132	(ABC) transporter
HPY09_18950	COG1902	pentaerythritol trinitrate reductase activity
HPY09_18960	COG1280	lysine exporter protein (LysE YggA)
HPY09_18965	COG2207	Transcriptional regulator
HPY09_18985	COG1846	Transcriptional regulator
HPY09_18990	COG1764	response to oxidative stress
HPY09_18995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY09_19000	COG0697	spore germination
HPY09_19010	COG0700	Nucleoside recognition
HPY09_19015	COG3366	ferrous iron transmembrane transporter activity
HPY09_19020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY09_19030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY09_19035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY09_19040	COG2259	Doxx family
HPY09_19065	COG0363	glucosamine-6-phosphate deaminase activity
HPY09_19080	COG4580	involved in the transport of maltose and maltodextrins
HPY09_19095	COG0840	transmembrane signaling receptor activity
HPY09_19110	COG0840	transmembrane signaling receptor activity
HPY09_19115	COG5001	Diguanylate cyclase
HPY09_19125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY09_19130	COG1126	abc transporter atp-binding protein
HPY09_19140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_19145	COG4597	amino acid ABC transporter
HPY09_19150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY09_19155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_19155	COG2213	PTS system mannitol-specific
HPY09_19160	COG0246	Mannitol dehydrogenase
HPY09_19165	COG3722	fumarate hydratase activity
HPY09_19170	COG0673	inositol 2-dehydrogenase activity
HPY09_19200	COG2910	NAD(P)H-binding
HPY09_19210	COG0840	transmembrane signaling receptor activity
HPY09_19215	COG4221	oxidoreductase activity
HPY09_19225	COG1901	pseudouridine methyltransferase
HPY09_19240	COG0531	amino acid
HPY09_19245	COG1982	Orn Lys Arg decarboxylase major
HPY09_19255	COG2197	response regulator
HPY09_19295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY09_19320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY09_19385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY09_19390	COG0840	transmembrane signaling receptor activity
HPY09_19395	COG0835	chemotaxis
HPY09_19400	COG0835	chemotaxis
HPY09_19405	COG2198	Histidine kinase
HPY09_19405	COG0643	Histidine kinase
HPY09_19420	COG0747	negative chemotaxis
HPY09_19425	COG0601	transmembrane transport
HPY09_19430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_19435	COG4608	Belongs to the ABC transporter superfamily
HPY09_19440	COG2194	sulfuric ester hydrolase activity
HPY09_19445	COG0642	Histidine kinase
HPY09_19450	COG0745	RESPONSE REGULATOR receiver
HPY09_19460	COG4221	oxidoreductase activity
HPY09_19480	COG1444	tRNA N-acetyltransferase activity
HPY09_19485	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY09_19595	COG0653	protein targeting
HPY09_19625	COG0776	regulation of translation
HPY09_19740	COG0754	glutathionylspermidine amidase activity
HPY09_19760	COG1842	Phage shock protein A
HPY09_19795	COG2026	Addiction module toxin, RelE StbE family
HPY09_19930	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY09_20050	COG5001	Diguanylate cyclase
HPY09_20050	COG3300	MHYT domain
HPY09_20405	COG1199	ATP-dependent helicase activity
HPY09_20445	COG0210	DNA helicase
HPY09_20495	COG4206	TonB-dependent receptor
HPY09_20575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY09_20650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY09_20665	COG0681	Belongs to the peptidase S26 family
HPY09_20690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY09_20795	COG1475	DNA binding
HPY09_21045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates