locus-tag	class	description
IS519_00005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IS519_00015	COG2350	Protein conserved in bacteria
IS519_00020	COG1607	acyl-coa hydrolase
IS519_00025	COG2917	probably involved in intracellular septation
IS519_00055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IS519_00065	COG1301	dicarboxylic acid transport
IS519_00075	COG0330	HflC and HflK could
IS519_00080	COG0159	tryptophan synthase activity
IS519_00085	COG0133	tryptophan synthase activity
IS519_00090	COG0134	indole-3-glycerol-phosphate synthase activity
IS519_00090	COG0135	phosphoribosylanthranilate isomerase activity
IS519_00095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IS519_00100	COG0512	Glutamine amidotransferase of anthranilate synthase
IS519_00105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IS519_00115	COG0613	PHP domain protein
IS519_00120	COG0009	L-threonylcarbamoyladenylate synthase
IS519_00125	COG1187	pseudouridine synthase activity
IS519_00140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IS519_00150	COG0417	DNA replication proofreading
IS519_00155	COG2197	response regulator
IS519_00160	COG0322	excinuclease ABC activity
IS519_00200	COG0019	diaminopimelate decarboxylase activity
IS519_00215	COG1058	Belongs to the CinA family
IS519_00215	COG1546	Belongs to the CinA family
IS519_00220	COG3302	dmso reductase anchor subunit
IS519_00225	COG0437	4 iron, 4 sulfur cluster binding
IS519_00230	COG0243	molybdopterin cofactor binding
IS519_00235	COG3381	protein complex oligomerization
IS519_00250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS519_00255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IS519_00260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS519_00275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS519_00280	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IS519_00285	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IS519_00290	COG0437	4 iron, 4 sulfur cluster binding
IS519_00295	COG3301	Polysulphide reductase, NrfD
IS519_00300	COG1138	Cytochrome C-type biogenesis protein
IS519_00310	COG3088	subunit of a heme lyase
IS519_00310	COG4235	cytochrome complex assembly
IS519_00320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IS519_00345	COG2989	Protein conserved in bacteria
IS519_00350	COG3108	Peptidase M15
IS519_00355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS519_00370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IS519_00395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS519_00400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS519_00405	COG0840	transmembrane signaling receptor activity
IS519_00415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IS519_00420	COG4988	ABC transporter
IS519_00425	COG0492	ferredoxin-NADP+ reductase activity
IS519_00455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS519_00470	COG2199	diguanylate cyclase activity
IS519_00490	COG0471	metal ion transport
IS519_00495	COG2949	membrane
IS519_00500	COG0281	malic enzyme
IS519_00505	COG1643	Atp-dependent helicase
IS519_00515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IS519_00540	COG2885	chlorophyll binding
IS519_00555	COG0277	FAD linked oxidase domain protein
IS519_00555	COG0247	lactate metabolic process
IS519_00570	COG2986	histidine ammonia-lyase
IS519_00575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IS519_00580	COG0010	Belongs to the arginase family
IS519_00585	COG1228	amidohydrolase
IS519_00595	COG4326	sporulation control protein
IS519_00615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IS519_00620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IS519_00625	COG3097	Belongs to the UPF0267 family
IS519_00640	COG0488	(ABC) transporter
IS519_00645	COG1309	transcriptional regulator
IS519_00655	COG1166	arginine decarboxylase activity
IS519_00660	COG0010	Belongs to the arginase family
IS519_00675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_00680	COG0800	Aldolase
IS519_00685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_00690	COG1917	Cupin 2, conserved barrel domain protein
IS519_00715	COG3639	organic phosphonate transmembrane transporter activity
IS519_00720	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IS519_00730	COG2186	Transcriptional regulator
IS519_00735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_00750	COG0840	transmembrane signaling receptor activity
IS519_00790	COG2186	Transcriptional regulator
IS519_00795	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_00800	COG2186	Transcriptional regulator
IS519_00805	COG0517	IMP dehydrogenase activity
IS519_00810	COG2176	DNA-directed DNA polymerase activity
IS519_00830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_00880	COG0741	lytic transglycosylase activity
IS519_00880	COG1196	nuclear chromosome segregation
IS519_00880	COG0739	heme binding
IS519_00915	COG0471	metal ion transport
IS519_00920	COG4191	Histidine kinase
IS519_00920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS519_00945	COG4977	sequence-specific DNA binding
IS519_00955	COG0454	-acetyltransferase
IS519_00985	COG0730	response to heat
IS519_01005	COG5642	Protein of unknown function (DUF2384)
IS519_01015	COG2211	Major facilitator Superfamily
IS519_01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_01030	COG0583	DNA-binding transcription factor activity
IS519_01035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IS519_01040	COG1280	lysine exporter protein (LysE YggA)
IS519_01060	COG1115	amino acid carrier protein
IS519_01075	COG1115	amino acid carrier protein
IS519_01090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_01105	COG3290	protein histidine kinase activity
IS519_01110	COG4565	transcriptional regulatory protein
IS519_01115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IS519_01120	COG0363	glucosamine-6-phosphate deaminase activity
IS519_01125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IS519_01135	COG4628	conserved protein (DUF2132)
IS519_01170	COG3437	response regulator, receiver
IS519_01175	COG0515	serine threonine protein kinase
IS519_01175	COG2815	serine threonine protein kinase
IS519_01280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IS519_01290	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IS519_01295	COG0372	Belongs to the citrate synthase family
IS519_01300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IS519_01305	COG2828	Protein conserved in bacteria
IS519_01335	COG0561	phosphatase activity
IS519_01340	COG0602	queuosine metabolic process
IS519_01345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IS519_01350	COG3706	GGDEF domain
IS519_01360	COG2885	chlorophyll binding
IS519_01450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IS519_01455	COG0840	transmembrane signaling receptor activity
IS519_01460	COG1254	Belongs to the acylphosphatase family
IS519_01465	COG2920	part of a sulfur-relay system
IS519_01470	COG0670	Belongs to the BI1 family
IS519_01475	COG1126	abc transporter atp-binding protein
IS519_01480	COG0765	amino acid transport
IS519_01485	COG4597	amino acid ABC transporter
IS519_01490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS519_01500	COG1666	GTP binding
IS519_01505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS519_01510	COG0574	Belongs to the PEP-utilizing enzyme family
IS519_01510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IS519_01525	COG2996	Protein conserved in bacteria
IS519_01530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IS519_01530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IS519_01535	COG3008	intermembrane lipid transfer
IS519_01540	COG2995	paraquat-inducible protein a
IS519_01545	COG1132	(ABC) transporter
IS519_01550	COG1956	GAF domain-containing protein
IS519_01555	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IS519_01570	COG0308	aminopeptidase N
IS519_01580	COG2902	Dehydrogenase
IS519_01585	COG0167	dihydroorotate dehydrogenase activity
IS519_01595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IS519_01595	COG0116	Belongs to the methyltransferase superfamily
IS519_01605	COG0488	(ABC) transporter
IS519_01625	COG1067	ATP-dependent peptidase activity
IS519_01630	COG3120	sequence-specific DNA binding
IS519_01715	COG4128	Pfam Zonular occludens toxin
IS519_01765	COG0784	Response regulator, receiver
IS519_01765	COG2205	protein histidine kinase activity
IS519_01780	COG3278	Belongs to the heme-copper respiratory oxidase family
IS519_01795	COG2010	Cytochrome c
IS519_01805	COG2217	Heavy metal translocating P-type atpase
IS519_01820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS519_01825	COG0589	response to stress
IS519_01830	COG0037	tRNA processing
IS519_01850	COG3842	ATPase activity
IS519_01860	COG1177	transmembrane transport
IS519_01870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IS519_01880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IS519_01885	COG0004	ammonium transporteR
IS519_01900	COG0437	4 iron, 4 sulfur cluster binding
IS519_01905	COG3383	formate dehydrogenase (NAD+) activity
IS519_01905	COG0243	molybdopterin cofactor binding
IS519_01915	COG3381	protein complex oligomerization
IS519_01935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IS519_01950	COG3220	belongs to the UPF0276 family
IS519_01965	COG1271	oxidase subunit
IS519_01970	COG1294	oxidase, subunit
IS519_01975	COG4890	Cyd operon protein YbgT
IS519_01985	COG0488	(ABC) transporter
IS519_02005	COG4191	Histidine kinase
IS519_02010	COG2204	response regulator
IS519_02020	COG4662	Binding-protein-dependent transport system inner membrane component
IS519_02025	COG3842	ATPase activity
IS519_02030	COG0746	molybdenum cofactor guanylyltransferase activity
IS519_02035	COG0303	'Molybdopterin
IS519_02045	COG1940	carbohydrate kinase activity
IS519_02050	COG3148	PFAM DTW domain containing protein
IS519_02065	COG0791	NLP P60 protein
IS519_02075	COG3001	Fructosamine kinase
IS519_02085	COG0307	riboflavin synthase, alpha
IS519_02090	COG0534	Mate efflux family protein
IS519_02095	COG1793	dna ligase
IS519_02105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IS519_02105	COG2885	chlorophyll binding
IS519_02125	COG4176	ABC-type proline glycine betaine transport system permease component
IS519_02130	COG3448	diguanylate cyclase activity
IS519_02130	COG4175	Glycine betaine
IS519_02140	COG2204	response regulator
IS519_02145	COG0438	transferase activity, transferring glycosyl groups
IS519_02175	COG1215	transferase activity, transferring glycosyl groups
IS519_02180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IS519_02185	COG0583	DNA-binding transcription factor activity
IS519_02205	COG1742	UPF0060 membrane protein
IS519_02280	COG3547	Transposase (IS116 IS110 IS902 family)
IS519_02295	COG3547	Transposase (IS116 IS110 IS902 family)
IS519_02320	COG4160	amino acid transport
IS519_02325	COG4215	(ABC) transporter
IS519_02330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS519_02335	COG1126	abc transporter atp-binding protein
IS519_02350	COG0826	peptidase U32
IS519_02400	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_02410	COG0546	phosphoglycolate phosphatase activity
IS519_02415	COG0653	protein targeting
IS519_02430	COG1619	proteins homologs of microcin C7 resistance protein MccF
IS519_02460	COG0346	lactoylglutathione lyase activity
IS519_02505	COG1051	belongs to the nudix hydrolase family
IS519_02515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS519_02515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS519_02530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS519_02545	COG0110	maltose O-acetyltransferase activity
IS519_02555	COG1187	pseudouridine synthase activity
IS519_02570	COG0494	nUDIX hydrolase
IS519_02595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS519_02605	COG0584	glycerophosphoryl diester phosphodiesterase
IS519_02610	COG2271	Major facilitator Superfamily
IS519_02640	COG0589	response to stress
IS519_02645	COG0415	Belongs to the DNA photolyase family
IS519_02650	COG3046	protein related to deoxyribodipyrimidine photolyase
IS519_02655	COG1088	dTDP-glucose 4,6-dehydratase activity
IS519_02670	COG0419	ATPase involved in DNA repair
IS519_02675	COG0420	3'-5' exonuclease activity
IS519_02695	COG0454	-acetyltransferase
IS519_02700	COG2199	diguanylate cyclase activity
IS519_02705	COG2226	methyltransferase
IS519_02710	COG4771	TonB-dependent receptor
IS519_02720	COG3469	chitinase activity
IS519_02735	COG0840	transmembrane signaling receptor activity
IS519_02750	COG0583	DNA-binding transcription factor activity
IS519_02755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IS519_02760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IS519_02770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IS519_02795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IS519_02815	COG0494	nUDIX hydrolase
IS519_02850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS519_02855	COG1012	belongs to the aldehyde dehydrogenase family
IS519_02860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS519_02865	COG1012	belongs to the aldehyde dehydrogenase family
IS519_02870	COG0596	Alpha beta hydrolase
IS519_02880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS519_02885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IS519_02895	COG2186	Transcriptional regulator
IS519_02900	COG2207	Transcriptional regulator
IS519_02905	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_02910	COG3119	arylsulfatase activity
IS519_02915	COG2149	membrane
IS519_02925	COG0641	radical SAM
IS519_02930	COG0328	RNA-DNA hybrid ribonuclease activity
IS519_02940	COG2003	Belongs to the UPF0758 family
IS519_03000	COG0784	Response regulator, receiver
IS519_03000	COG5002	protein histidine kinase activity
IS519_03000	COG2205	protein histidine kinase activity
IS519_03005	COG3437	response regulator, receiver
IS519_03015	COG0784	Response regulator, receiver
IS519_03015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IS519_03015	COG2198	Histidine kinase
IS519_03015	COG2205	protein histidine kinase activity
IS519_03020	COG0778	Nitroreductase
IS519_03030	COG1733	regulation of RNA biosynthetic process
IS519_03050	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS519_03055	COG1129	ABC transporter
IS519_03070	COG0582	viral genome integration into host DNA
IS519_03090	COG3706	GGDEF domain
IS519_03095	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS519_03110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IS519_03115	COG3063	Type IV pilus biogenesis stability protein PilW
IS519_03125	COG1451	nucleotide metabolic process
IS519_03135	COG0583	DNA-binding transcription factor activity
IS519_03140	COG2814	Major facilitator Superfamily
IS519_03160	COG1247	-acetyltransferase
IS519_03175	COG1294	oxidase, subunit
IS519_03180	COG1271	oxidase subunit
IS519_03185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS519_03200	COG3397	chitin binding
IS519_03210	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IS519_03215	COG4139	cobalamin transport
IS519_03220	COG2988	succinylglutamate desuccinylase activity
IS519_03240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IS519_03245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IS519_03250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IS519_03255	COG0702	epimerase
IS519_03260	COG1823	symporter activity
IS519_03270	COG4989	oxidoreductase activity
IS519_03295	COG3122	Protein conserved in bacteria
IS519_03300	COG3568	Endonuclease Exonuclease Phosphatase
IS519_03345	COG2925	Exonuclease
IS519_03355	COG1346	cytolysis
IS519_03360	COG0295	cytidine deaminase activity
IS519_03365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IS519_03370	COG0500	methyltransferase
IS519_03400	COG0776	regulation of translation
IS519_03405	COG0456	acetyltransferase
IS519_03420	COG0523	cobalamin synthesis protein
IS519_03430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS519_03445	COG2175	clavaminate synthase activity
IS519_03490	COG0840	transmembrane signaling receptor activity
IS519_03530	COG0776	regulation of translation
IS519_03555	COG1342	Belongs to the UPF0251 family
IS519_03570	COG2205	protein histidine kinase activity
IS519_03590	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IS519_03615	COG1289	transmembrane transporter activity
IS519_03630	COG0583	DNA-binding transcription factor activity
IS519_03635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IS519_03645	COG0697	spore germination
IS519_03655	COG2873	o-acetylhomoserine
IS519_03660	COG1522	sequence-specific DNA binding
IS519_03705	COG0596	Alpha beta hydrolase
IS519_03750	COG0072	phenylalanine-tRNA ligase activity
IS519_03750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS519_03755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IS519_03800	COG1643	Atp-dependent helicase
IS519_03830	COG3710	Transcriptional regulator
IS519_03850	COG3706	GGDEF domain
IS519_03865	COG0443	Heat shock 70 kDa protein
IS519_03880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS519_03895	COG3106	COG3106 Predicted ATPase
IS519_03915	COG5002	protein histidine kinase activity
IS519_03915	COG0784	Response regulator, receiver
IS519_03925	COG0494	nUDIX hydrolase
IS519_03930	COG0814	amino acid
IS519_03935	COG1760	l-serine dehydratase
IS519_03940	COG0814	amino acid
IS519_03945	COG0840	transmembrane signaling receptor activity
IS519_03950	COG0659	secondary active sulfate transmembrane transporter activity
IS519_03955	COG0017	Asparaginyl-tRNA synthetase
IS519_03965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS519_03975	COG3437	response regulator, receiver
IS519_03975	COG2770	Histidine kinase
IS519_03980	COG1448	Aminotransferase
IS519_04010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IS519_04020	COG3852	Histidine kinase
IS519_04025	COG2204	response regulator
IS519_04035	COG3070	regulator of competence-specific genes
IS519_04045	COG2431	L-lysine efflux transmembrane transporter activity
IS519_04055	COG0076	glutamate decarboxylase activity
IS519_04060	COG1737	Transcriptional regulator
IS519_04070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS519_04075	COG3273	potassium ion transport
IS519_04075	COG2985	domain, Protein
IS519_04080	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS519_04110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IS519_04130	COG0534	Mate efflux family protein
IS519_04135	COG0702	epimerase
IS519_04145	COG2814	Major facilitator Superfamily
IS519_04155	COG1061	Type III restriction enzyme res subunit
IS519_04170	COG0642	Histidine kinase
IS519_04175	COG1902	pentaerythritol trinitrate reductase activity
IS519_04180	COG0583	DNA-binding transcription factor activity
IS519_04185	COG0586	Pfam SNARE associated Golgi protein
IS519_04195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IS519_04255	COG0745	RESPONSE REGULATOR receiver
IS519_04335	COG0784	Response regulator, receiver
IS519_04335	COG3437	response regulator, receiver
IS519_04345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS519_04345	COG3008	intermembrane lipid transfer
IS519_04350	COG2995	paraquat-inducible protein a
IS519_04360	COG0583	DNA-binding transcription factor activity
IS519_04370	COG2113	Glycine betaine
IS519_04375	COG4176	ABC-type proline glycine betaine transport system permease component
IS519_04400	COG2866	Carboxypeptidase
IS519_04410	COG1280	lysine exporter protein (LysE YggA)
IS519_04415	COG0513	Belongs to the DEAD box helicase family
IS519_04435	COG3313	Fe-S protein
IS519_04445	COG4134	Bacterial extracellular solute-binding protein
IS519_04450	COG4135	transport system, permease component
IS519_04455	COG4136	ATPase activity
IS519_04460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IS519_04515	COG4964	Belongs to the GSP D family
IS519_04535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IS519_04535	COG0116	Belongs to the methyltransferase superfamily
IS519_04540	COG0564	pseudouridine synthase activity
IS519_04550	COG0733	neurotransmitter:sodium symporter activity
IS519_04560	COG0626	cystathionine gamma-synthase activity
IS519_04575	COG2818	Glycosylase
IS519_04590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_04595	COG1983	PspC domain protein
IS519_04605	COG1842	Phage shock protein A
IS519_04610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IS519_04615	COG4166	transmembrane transport
IS519_04620	COG4168	peptide transport system, permease
IS519_04635	COG4172	Belongs to the ABC transporter superfamily
IS519_04650	COG1227	inorganic diphosphatase activity
IS519_04660	COG0243	molybdopterin cofactor binding
IS519_04665	COG3005	denitrification pathway
IS519_04670	COG4459	periplasmic nitrate reductase
IS519_04675	COG0390	transport system, permease component
IS519_04680	COG2116	formate transmembrane transporter activity
IS519_04710	COG0215	cysteine-tRNA ligase activity
IS519_04715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS519_04720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IS519_04725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IS519_04730	COG3012	SEC-C Motif Domain Protein
IS519_04735	COG0140	phosphoribosyl-ATP diphosphatase activity
IS519_04735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IS519_04740	COG0107	imidazoleglycerol-phosphate synthase activity
IS519_04745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IS519_04750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IS519_04755	COG0131	Imidazoleglycerol-phosphate dehydratase
IS519_04755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS519_04760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS519_04775	COG1757	Na H antiporter
IS519_04780	COG2916	Histone family protein nucleoid-structuring protein H-NS
IS519_04785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_04800	COG2915	High frequency lysogenization protein hflD homolog
IS519_04805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IS519_04810	COG0501	Belongs to the peptidase M48B family
IS519_04825	COG2226	methyltransferase
IS519_04830	COG0156	8-amino-7-oxononanoate synthase activity
IS519_04835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IS519_04840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IS519_04850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IS519_04855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IS519_04860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IS519_04865	COG1674	ftsk spoiiie
IS519_04870	COG1522	sequence-specific DNA binding
IS519_04875	COG0686	Belongs to the AlaDH PNT family
IS519_04885	COG0583	DNA-binding transcription factor activity
IS519_04900	COG0284	orotidine-5'-phosphate decarboxylase activity
IS519_04905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IS519_04910	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IS519_04915	COG0776	regulation of translation
IS519_04920	COG0539	negative regulation of cytoplasmic translation
IS519_04925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IS519_04930	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IS519_04935	COG2835	tetraacyldisaccharide 4'-kinase activity
IS519_04940	COG1663	tetraacyldisaccharide 4'-kinase activity
IS519_04945	COG1132	(ABC) transporter
IS519_04950	COG0658	competence protein
IS519_04950	COG2333	competence protein COMEC
IS519_04960	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS519_04965	COG1136	(ABC) transporter
IS519_04970	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS519_04980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IS519_04995	COG1252	NADH dehydrogenase
IS519_05000	COG3150	esterase
IS519_05025	COG0537	adenosine 5'-monophosphoramidase activity
IS519_05045	COG2217	Heavy metal translocating P-type atpase
IS519_05055	COG0517	IMP dehydrogenase activity
IS519_05055	COG0617	tRNA 3'-terminal CCA addition
IS519_05055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IS519_05080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS519_05105	COG1902	pentaerythritol trinitrate reductase activity
IS519_05110	COG0346	lactoylglutathione lyase activity
IS519_05135	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IS519_05150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IS519_05155	COG1845	cytochrome c oxidase, subunit III
IS519_05160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS519_05165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS519_05170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS519_05180	COG1309	transcriptional regulator
IS519_05185	COG0583	DNA-binding transcription factor activity
IS519_05205	COG3040	lipid binding
IS519_05220	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IS519_05230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IS519_05240	COG3118	belongs to the thioredoxin family
IS519_05245	COG4232	protein-disulfide reductase activity
IS519_05270	COG0697	spore germination
IS519_05280	COG0583	DNA-binding transcription factor activity
IS519_05290	COG1227	inorganic diphosphatase activity
IS519_05295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS519_05305	COG2233	PERMEase
IS519_05315	COG2207	Transcriptional regulator
IS519_05315	COG3708	Transcriptional regulator
IS519_05340	COG1280	lysine exporter protein (LysE YggA)
IS519_05345	COG1522	sequence-specific DNA binding
IS519_05350	COG1760	l-serine dehydratase
IS519_05375	COG1609	Transcriptional regulator
IS519_05380	COG3119	arylsulfatase activity
IS519_05410	COG0583	DNA-binding transcription factor activity
IS519_05415	COG1486	melibiose metabolic process
IS519_05425	COG0789	Transcriptional regulator
IS519_05430	COG0583	DNA-binding transcription factor activity
IS519_05445	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IS519_05475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IS519_05510	COG0463	Glycosyl transferase, family 2
IS519_05510	COG1216	Glycosyl transferase, family 2
IS519_05515	COG0438	transferase activity, transferring glycosyl groups
IS519_05520	COG0328	RNA-DNA hybrid ribonuclease activity
IS519_05520	COG3341	Caulimovirus viroplasmin
IS519_05580	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IS519_05585	COG1946	Acyl-CoA thioesterase
IS519_05595	COG1522	sequence-specific DNA binding
IS519_05600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IS519_05650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS519_05715	COG2855	membrane
IS519_05730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS519_05730	COG2190	(PTS) system
IS519_05730	COG1263	PTS System
IS519_05750	COG2267	carboxylic ester hydrolase activity
IS519_05755	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IS519_05760	COG1169	isochorismate synthase
IS519_05765	COG0436	Aminotransferase
IS519_05770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IS519_05775	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IS519_05790	COG2183	response to ionizing radiation
IS519_05795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS519_05800	COG0776	regulation of translation
IS519_05805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IS519_05810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IS519_05815	COG0740	serine-type endopeptidase activity
IS519_05820	COG0544	peptidyl-prolyl cis-trans isomerase activity
IS519_05835	COG2204	response regulator
IS519_05845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IS519_05850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IS519_05855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IS519_05870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IS519_05870	COG3321	synthase
IS519_05885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IS519_05885	COG2070	2-Nitropropane dioxygenase
IS519_05890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS519_05895	COG3842	ATPase activity
IS519_05905	COG1175	transmembrane transport
IS519_05925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IS519_05930	COG1280	lysine exporter protein (LysE YggA)
IS519_05935	COG2890	protein-(glutamine-N5) methyltransferase activity
IS519_05945	COG2062	phosphohistidine phosphatase, SixA
IS519_05955	COG1024	Enoyl-CoA hydratase
IS519_05955	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS519_05960	COG0183	Belongs to the thiolase family
IS519_05975	COG2067	long-chain fatty acid transport protein
IS519_05980	COG2067	long-chain fatty acid transport protein
IS519_05985	COG2853	Lipoprotein
IS519_05990	COG4235	cytochrome complex assembly
IS519_05990	COG3088	subunit of a heme lyase
IS519_05995	COG3088	subunit of a heme lyase
IS519_05995	COG4235	cytochrome complex assembly
IS519_06000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IS519_06005	COG1138	Cytochrome C-type biogenesis protein
IS519_06010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IS519_06015	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS519_06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS519_06025	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IS519_06030	COG4133	protoheme IX ABC transporter activity
IS519_06040	COG0835	chemotaxis
IS519_06050	COG1192	Involved in chromosome partitioning
IS519_06055	COG2201	protein-glutamate methylesterase activity
IS519_06060	COG0784	Response regulator, receiver
IS519_06060	COG2198	Histidine kinase
IS519_06060	COG0643	Histidine kinase
IS519_06065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IS519_06100	COG1684	flagellar biosynthetic protein fliR
IS519_06105	COG1987	bacterial-type flagellum assembly
IS519_06155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IS519_06165	COG1677	Flagellar hook-basal body complex protein FliE
IS519_06185	COG1516	flagellar protein fliS
IS519_06195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IS519_06205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IS519_06210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IS519_06230	COG3951	Flagellar rod assembly protein muramidase FlgJ
IS519_06230	COG1705	Flagellar rod assembly protein muramidase FlgJ
IS519_06235	COG1706	bacterial-type flagellum-dependent cell motility
IS519_06240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IS519_06250	COG4787	bacterial-type flagellum-dependent cell motility
IS519_06255	COG1749	Flagellar hook protein flgE
IS519_06265	COG1558	bacterial-type flagellum-dependent cell motility
IS519_06270	COG1815	bacterial-type flagellum-dependent cell motility
IS519_06275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IS519_06280	COG0784	Response regulator, receiver
IS519_06280	COG0835	chemotaxis
IS519_06285	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IS519_06345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IS519_06350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IS519_06370	COG1216	Glycosyl transferase, family 2
IS519_06375	COG2986	histidine ammonia-lyase
IS519_06410	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_06430	COG2217	Heavy metal translocating P-type atpase
IS519_06430	COG2608	mercury ion transmembrane transporter activity
IS519_06470	COG2840	Smr protein MutS2
IS519_06475	COG1187	pseudouridine synthase activity
IS519_06480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IS519_06490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IS519_06495	COG2912	Transglutaminase-like superfamily
IS519_06500	COG3094	Invasion gene expression up-regulator, SirB
IS519_06505	COG2890	protein-(glutamine-N5) methyltransferase activity
IS519_06510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IS519_06515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IS519_06520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IS519_06525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IS519_06530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IS519_06535	COG0193	aminoacyl-tRNA hydrolase activity
IS519_06640	COG2706	6-phosphogluconolactonase activity
IS519_06645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS519_06655	COG1702	phosphate starvation-inducible protein PhoH
IS519_06660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IS519_06665	COG4535	Mg2 and Co2 transporter CorC
IS519_06670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IS519_06675	COG2888	peptidyl-tyrosine sulfation
IS519_06680	COG0495	leucyl-tRNA aminoacylation
IS519_06685	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IS519_06690	COG1466	dna polymerase III delta subunit
IS519_06695	COG0799	negative regulation of ribosome biogenesis
IS519_06700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IS519_06705	COG0768	penicillin binding
IS519_06710	COG0772	Belongs to the SEDS family
IS519_06715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IS519_06720	COG1686	Belongs to the peptidase S11 family
IS519_06730	COG0321	lipoyl(octanoyl) transferase activity
IS519_06735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IS519_06740	COG0733	neurotransmitter:sodium symporter activity
IS519_06760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS519_06770	COG2991	Protein conserved in bacteria
IS519_06775	COG1477	protein flavinylation
IS519_06780	COG2871	sodium ion transport
IS519_06785	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS519_06790	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS519_06800	COG1805	sodium ion transport
IS519_06805	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IS519_06810	COG0271	Belongs to the BolA IbaG family
IS519_06815	COG2813	Specifically methylates the guanine in position
IS519_06825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IS519_06840	COG3248	Nucleoside-binding outer membrane protein
IS519_06845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IS519_06850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IS519_06855	COG2166	iron-sulfur cluster assembly
IS519_06860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IS519_06865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IS519_06875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IS519_06875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IS519_06885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IS519_06890	COG1074	ATP-dependent DNA helicase activity
IS519_06900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IS519_06910	COG0583	DNA-binding transcription factor activity
IS519_06915	COG3141	response to X-ray
IS519_06930	COG2095	MarC family integral membrane protein
IS519_06935	COG0737	Belongs to the 5'-nucleotidase family
IS519_06940	COG2171	N-acyltransferase activity
IS519_06950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IS519_06950	COG0047	phosphoribosylformylglycinamidine synthase activity
IS519_06965	COG1253	flavin adenine dinucleotide binding
IS519_06970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IS519_07000	COG0484	heat shock protein binding
IS519_07005	COG0443	Heat shock 70 kDa protein
IS519_07020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IS519_07025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IS519_07035	COG0497	DNA recombination
IS519_07040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS519_07045	COG2914	Belongs to the UPF0125 (RnfH) family
IS519_07050	COG2867	negative regulation of translational initiation
IS519_07115	COG0582	viral genome integration into host DNA
IS519_07130	COG3850	Histidine kinase
IS519_07130	COG2205	protein histidine kinase activity
IS519_07130	COG3437	response regulator, receiver
IS519_07130	COG4999	Histidine kinase
IS519_07140	COG5492	domain, Protein
IS519_07140	COG4932	domain protein
IS519_07150	COG3064	Membrane
IS519_07175	COG2003	Belongs to the UPF0758 family
IS519_07195	COG1396	sequence-specific DNA binding
IS519_07200	COG3550	peptidyl-serine autophosphorylation
IS519_07205	COG4067	protein conserved in archaea
IS519_07205	COG0189	ligase activity
IS519_07230	COG0204	Acyl-transferase
IS519_07235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IS519_07240	COG1115	amino acid carrier protein
IS519_07245	COG1584	GPR1 FUN34 yaaH family protein
IS519_07250	COG1757	Na H antiporter
IS519_07260	COG0519	Catalyzes the synthesis of GMP from XMP
IS519_07260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IS519_07265	COG0516	GMP reductase activity
IS519_07265	COG0517	IMP dehydrogenase activity
IS519_07270	COG1570	exodeoxyribonuclease VII activity
IS519_07275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IS519_07290	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IS519_07295	COG0804	urea catabolic process
IS519_07300	COG0832	Belongs to the urease beta subunit family
IS519_07305	COG0831	urea catabolic process
IS519_07345	COG3706	GGDEF domain
IS519_07355	COG1160	GTP binding
IS519_07360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS519_07365	COG2976	Protein conserved in bacteria
IS519_07370	COG0124	histidyl-tRNA synthetase
IS519_07375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IS519_07385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IS519_07390	COG0105	UTP biosynthetic process
IS519_07395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IS519_07400	COG2975	iron-sulfur cluster assembly
IS519_07410	COG0443	Heat shock 70 kDa protein
IS519_07415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS519_07425	COG0822	iron-sulfur transferase activity
IS519_07430	COG1104	cysteine desulfurase activity
IS519_07435	COG1959	2 iron, 2 sulfur cluster binding
IS519_07440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IS519_07445	COG0483	inositol monophosphate 1-phosphatase activity
IS519_07450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS519_07455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS519_07460	COG1862	Preprotein translocase
IS519_07465	COG0343	queuine tRNA-ribosyltransferase activity
IS519_07470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IS519_07475	COG0517	IMP dehydrogenase activity
IS519_07480	COG0583	DNA-binding transcription factor activity
IS519_07485	COG0450	alkyl hydroperoxide reductase
IS519_07490	COG3142	Participates in the control of copper homeostasis
IS519_07500	COG0704	Plays a role in the regulation of phosphate uptake
IS519_07505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS519_07510	COG0581	inorganic phosphate transmembrane transporter activity
IS519_07515	COG0573	inorganic phosphate transmembrane transporter activity
IS519_07520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IS519_07525	COG0248	Ppx GppA phosphatase
IS519_07535	COG5002	protein histidine kinase activity
IS519_07540	COG0745	RESPONSE REGULATOR receiver
IS519_07545	COG2974	May be involved in recombination
IS519_07550	COG0826	peptidase U32
IS519_07555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IS519_07565	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IS519_07610	COG0564	pseudouridine synthase activity
IS519_07615	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IS519_07620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IS519_07625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS519_07630	COG1605	Chorismate mutase
IS519_07630	COG0077	Prephenate dehydratase
IS519_07635	COG5001	Diguanylate cyclase
IS519_07640	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IS519_07645	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IS519_07655	COG0488	(ABC) transporter
IS519_07665	COG0739	heme binding
IS519_07670	COG0287	Prephenate dehydrogenase
IS519_07670	COG1605	Chorismate mutase
IS519_07675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS519_07685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IS519_07690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IS519_07700	COG1966	Carbon starvation protein
IS519_07705	COG3275	phosphorelay sensor kinase activity
IS519_07710	COG3279	Response regulator of the LytR AlgR family
IS519_07715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IS519_07720	COG1047	Peptidyl-prolyl cis-trans
IS519_07730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IS519_07735	COG0196	riboflavin kinase activity
IS519_07740	COG0728	peptidoglycan biosynthetic process
IS519_07745	COG0268	Binds directly to 16S ribosomal RNA
IS519_07750	COG0640	Transcriptional regulator
IS519_07755	COG0583	DNA-binding transcription factor activity
IS519_07760	COG1283	sodium-dependent phosphate transmembrane transporter activity
IS519_07775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IS519_07780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IS519_07785	COG0730	response to heat
IS519_07790	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IS519_07795	COG0494	nUDIX hydrolase
IS519_07830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IS519_07835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS519_07840	COG4974	Belongs to the 'phage' integrase family
IS519_07845	COG0716	FMN binding
IS519_07855	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IS519_07860	COG0513	Belongs to the DEAD box helicase family
IS519_07865	COG3022	response to hydroperoxide
IS519_07870	COG1115	amino acid carrier protein
IS519_07885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IS519_07890	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IS519_07895	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IS519_07905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IS519_07910	COG0083	homoserine kinase activity
IS519_07925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS519_07930	COG0745	RESPONSE REGULATOR receiver
IS519_07940	COG0784	Response regulator, receiver
IS519_07940	COG5002	protein histidine kinase activity
IS519_07940	COG2198	Histidine kinase
IS519_07945	COG2203	Gaf domain
IS519_07945	COG5001	Diguanylate cyclase
IS519_07945	COG3706	GGDEF domain
IS519_07945	COG4251	negative regulation of phosphorylation
IS519_07950	COG1242	4 iron, 4 sulfur cluster binding
IS519_07955	COG0070	glutamate synthase
IS519_07955	COG0069	glutamate synthase activity
IS519_07955	COG0067	glutamate synthase
IS519_07965	COG0067	glutamate synthase
IS519_07965	COG0069	glutamate synthase activity
IS519_07965	COG0070	glutamate synthase
IS519_07970	COG0493	'glutamate synthase
IS519_07980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IS519_07995	COG2860	membrane
IS519_08000	COG0655	NAD(P)H dehydrogenase (quinone) activity
IS519_08005	COG0583	DNA-binding transcription factor activity
IS519_08010	COG0730	response to heat
IS519_08015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IS519_08020	COG0505	Belongs to the CarA family
IS519_08025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IS519_08030	COG0494	nUDIX hydrolase
IS519_08035	COG0653	protein targeting
IS519_08040	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IS519_08045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IS519_08050	COG0849	cell division
IS519_08055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IS519_08060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS519_08065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IS519_08070	COG0772	Belongs to the SEDS family
IS519_08075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IS519_08080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IS519_08085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IS519_08090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IS519_08095	COG0768	penicillin binding
IS519_08100	COG3116	cell division
IS519_08105	COG0275	rRNA processing
IS519_08115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IS519_08130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IS519_08135	COG2823	Periplasmic or secreted lipoprotein
IS519_08140	COG2969	positive regulation of protein catabolic process
IS519_08145	COG0625	glutathione transferase activity
IS519_08150	COG2857	Cytochrome c1
IS519_08155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IS519_08160	COG0723	plastoquinol--plastocyanin reductase activity
IS519_08165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IS519_08170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IS519_08175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IS519_08180	COG3105	Protein conserved in bacteria
IS519_08185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS519_08190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IS519_08205	COG3150	esterase
IS519_08215	COG3151	Protein conserved in bacteria
IS519_08220	COG0494	nUDIX hydrolase
IS519_08225	COG1538	Outer membrane efflux protein
IS519_08230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IS519_08230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IS519_08235	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IS519_08245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS519_08250	COG3025	triphosphatase activity
IS519_08255	COG1392	Phosphate transport regulator
IS519_08260	COG0306	phosphate transporter
IS519_08265	COG4991	sh3 domain protein
IS519_08275	COG3409	Peptidoglycan-binding domain 1 protein
IS519_08275	COG3267	Type II secretory pathway component ExeA
IS519_08280	COG0617	tRNA 3'-terminal CCA addition
IS519_08285	COG1968	undecaprenyl-diphosphatase activity
IS519_08290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS519_08295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS519_08300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IS519_08305	COG0596	Alpha beta hydrolase
IS519_08310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IS519_08315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IS519_08320	COG1610	YqeY-like protein
IS519_08340	COG2873	o-acetylhomoserine
IS519_08345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IS519_08350	COG1349	DNA-binding transcription factor activity
IS519_08355	COG0469	pyruvate kinase activity
IS519_08365	COG3706	GGDEF domain
IS519_08375	COG0028	Belongs to the TPP enzyme family
IS519_08380	COG1022	Amp-dependent synthetase and ligase
IS519_08415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IS519_08420	COG0473	3-isopropylmalate dehydrogenase activity
IS519_08425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IS519_08430	COG0066	3-isopropylmalate dehydratase activity
IS519_08445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IS519_08450	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IS519_08455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS519_08460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IS519_08465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IS519_08470	COG2967	ApaG domain
IS519_08490	COG2966	Psort location CytoplasmicMembrane, score
IS519_08495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IS519_08500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IS519_08505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IS519_08510	COG0142	geranyltranstransferase activity
IS519_08520	COG0039	L-malate dehydrogenase activity
IS519_08525	COG1438	arginine binding
IS519_08540	COG0589	response to stress
IS519_08545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS519_08560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IS519_08565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IS519_08570	COG0312	modulator of DNA gyrase
IS519_08575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IS519_08590	COG0424	maF-like protein
IS519_08595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IS519_08600	COG1792	Involved in formation and maintenance of cell shape
IS519_08605	COG1077	Cell shape determining protein MreB Mrl
IS519_08635	COG2165	general secretion pathway protein
IS519_08640	COG2165	general secretion pathway protein
IS519_08650	COG1459	type II secretion system
IS519_08655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS519_08665	COG3267	Type II secretory pathway component ExeA
IS519_08665	COG3409	Peptidoglycan-binding domain 1 protein
IS519_08690	COG2199	diguanylate cyclase activity
IS519_08690	COG2200	EAL domain
IS519_08695	COG0629	single-stranded DNA binding
IS519_08700	COG2197	response regulator
IS519_08710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IS519_08720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IS519_08725	COG0527	aspartate kinase activity
IS519_08730	COG1410	methionine synthase
IS519_08730	COG0646	methionine synthase
IS519_08810	COG0175	sulfate reduction
IS519_08815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS519_08820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IS519_08865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_08875	COG3069	C4-dicarboxylate transmembrane transporter activity
IS519_08915	COG0735	belongs to the Fur family
IS519_08925	COG0166	Belongs to the GPI family
IS519_08930	COG0432	Pfam Uncharacterised protein family UPF0047
IS519_08940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IS519_08955	COG0359	binds to the 23S rRNA
IS519_08970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS519_08975	COG0557	exoribonuclease II activity
IS519_08980	COG0402	S-adenosylhomocysteine deaminase activity
IS519_08985	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IS519_08990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IS519_08995	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IS519_09000	COG0330	HflC and HflK could
IS519_09005	COG0330	HflC and HflK could
IS519_09010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IS519_09015	COG1923	regulation of RNA biosynthetic process
IS519_09020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IS519_09025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IS519_09030	COG0860	N-Acetylmuramoyl-L-alanine amidase
IS519_09035	COG0802	atpase or kinase
IS519_09040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IS519_09130	COG1162	GTPase activity
IS519_09135	COG0688	phosphatidylethanolamine metabolic process
IS519_09140	COG0490	domain, Protein
IS519_09140	COG0471	metal ion transport
IS519_09145	COG0840	transmembrane signaling receptor activity
IS519_09155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IS519_09160	COG1053	succinate dehydrogenase
IS519_09165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS519_09170	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IS519_09180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IS519_09185	COG1509	lysine 2,3-aminomutase activity
IS519_09195	COG1285	pathogenesis
IS519_09200	COG5001	Diguanylate cyclase
IS519_09235	COG0583	DNA-binding transcription factor activity
IS519_09255	COG0582	viral genome integration into host DNA
IS519_09310	COG0582	viral genome integration into host DNA
IS519_09325	COG0534	Mate efflux family protein
IS519_09335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IS519_09345	COG1596	polysaccharide export
IS519_09380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IS519_09460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS519_09465	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IS519_09475	COG1045	serine acetyltransferase
IS519_09480	COG4942	peptidase
IS519_09500	COG1560	Kdo2-lipid A biosynthetic process
IS519_09505	COG0859	PFAM glycosyl transferase family 9
IS519_09510	COG1519	Transferase
IS519_09525	COG2089	acid synthase
IS519_09535	COG0438	transferase activity, transferring glycosyl groups
IS519_09535	COG0297	glycogen (starch) synthase activity
IS519_09545	COG3642	lipopolysaccharide core region biosynthetic process
IS519_09550	COG0859	PFAM glycosyl transferase family 9
IS519_09555	COG0463	Glycosyl transferase, family 2
IS519_09560	COG0438	transferase activity, transferring glycosyl groups
IS519_09585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IS519_09595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IS519_09600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IS519_09605	COG2003	Belongs to the UPF0758 family
IS519_09615	COG1309	transcriptional regulator
IS519_09620	COG1560	Kdo2-lipid A biosynthetic process
IS519_09625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IS519_09630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IS519_09635	COG1561	YicC-like family, N-terminal region
IS519_09640	COG1278	Cold shock
IS519_09650	COG2252	PERMEase
IS519_09655	COG0194	GDP metabolic process
IS519_09660	COG1758	RNA polymerase activity
IS519_09665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS519_09670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IS519_09685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS519_09690	COG2183	response to ionizing radiation
IS519_09700	COG0596	Alpha beta hydrolase
IS519_09710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IS519_09710	COG0316	Belongs to the HesB IscA family
IS519_09715	COG0494	nUDIX hydrolase
IS519_09720	COG1218	3'(2'),5'-bisphosphate nucleotidase
IS519_09730	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IS519_09735	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IS519_09740	COG3156	type II secretion system protein K
IS519_09745	COG4795	General secretion pathway protein
IS519_09750	COG2165	general secretion pathway protein
IS519_09755	COG2165	general secretion pathway protein
IS519_09760	COG2165	general secretion pathway protein
IS519_09765	COG1459	type II secretion system
IS519_09770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS519_09780	COG3031	protein transport across the cell outer membrane
IS519_09785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IS519_09795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IS519_09805	COG0456	acetyltransferase
IS519_09810	COG1490	D-aminoacyl-tRNA deacylase activity
IS519_09815	COG1295	ribonuclease BN
IS519_09830	COG1217	gtp-binding protein TYPA
IS519_09835	COG0174	glutamine synthetase
IS519_09845	COG3852	Histidine kinase
IS519_09870	COG3078	GTPase activator activity
IS519_09895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IS519_09895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IS519_09910	COG0084	hydrolase, TatD family'
IS519_09915	COG0805	protein transport
IS519_09920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IS519_09925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IS519_09930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IS519_09935	COG3165	ubiquinone biosynthetic process from chorismate
IS519_09940	COG2226	methyltransferase
IS519_09945	COG1322	Protein conserved in bacteria
IS519_09955	COG2081	HI0933 family
IS519_09965	COG1528	Iron-storage protein
IS519_09970	COG0589	response to stress
IS519_09985	COG0742	ribosomal rna small subunit methyltransferase
IS519_09990	COG5001	Diguanylate cyclase
IS519_09990	COG5002	protein histidine kinase activity
IS519_09995	COG1522	sequence-specific DNA binding
IS519_10000	COG0339	signal peptide processing
IS519_10005	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IS519_10010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS519_10020	COG1805	sodium ion transport
IS519_10075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS519_10080	COG0601	transmembrane transport
IS519_10130	COG1309	transcriptional regulator
IS519_10135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_10140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS519_10145	COG2960	long-chain fatty acid transporting porin activity
IS519_10150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IS519_10155	COG0583	DNA-binding transcription factor activity
IS519_10200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IS519_10210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IS519_10215	COG0408	coproporphyrinogen oxidase activity
IS519_10220	COG0009	L-threonylcarbamoyladenylate synthase
IS519_10225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IS519_10230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IS519_10235	COG0551	DNA topoisomerase type I activity
IS519_10240	COG2922	Belongs to the Smg family
IS519_10245	COG0758	DNA mediated transformation
IS519_10255	COG0242	peptide deformylase activity
IS519_10265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IS519_10265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IS519_10270	COG0569	domain protein
IS519_10275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IS519_10285	COG1272	protein, Hemolysin III
IS519_10290	COG4326	sporulation control protein
IS519_10300	COG3084	Protein conserved in bacteria
IS519_10310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IS519_10315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IS519_10325	COG0606	chelatase, subunit chli
IS519_10335	COG3978	acetolactate synthase activity
IS519_10340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS519_10345	COG0129	dihydroxy-acid dehydratase activity
IS519_10355	COG0583	DNA-binding transcription factor activity
IS519_10360	COG2814	Major facilitator Superfamily
IS519_10370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IS519_10375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IS519_10380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IS519_10385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IS519_10390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IS519_10395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IS519_10410	COG3312	ion transport
IS519_10415	COG1475	DNA binding
IS519_10420	COG1192	Involved in chromosome partitioning
IS519_10425	COG0357	Ribosomal RNA small subunit methyltransferase G
IS519_10430	COG0445	tRNA wobble uridine modification
IS519_10435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IS519_10445	COG0706	membrane insertase activity
IS519_10450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IS519_10455	COG0594	ribonuclease P activity
IS519_10460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IS519_10465	COG1126	abc transporter atp-binding protein
IS519_10480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IS519_10485	COG0592	DNA-directed DNA polymerase activity
IS519_10490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IS519_10495	COG0187	DNA topoisomerase II activity
IS519_10500	COG4667	esterase of the alpha-beta hydrolase superfamily
IS519_10510	COG3977	Valine--pyruvate aminotransferase
IS519_10515	COG0366	Alpha amylase catalytic
IS519_10520	COG0751	glycine-tRNA ligase activity
IS519_10525	COG0752	glycyl-tRNA synthetase alpha subunit
IS519_10530	COG2119	membrane
IS519_10540	COG0425	Belongs to the sulfur carrier protein TusA family
IS519_10555	COG0604	alcohol dehydrogenase
IS519_10560	COG0183	Belongs to the thiolase family
IS519_10565	COG1024	Enoyl-CoA hydratase
IS519_10565	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS519_10570	COG1739	Uncharacterized protein family UPF0029
IS519_10575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IS519_10580	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IS519_10635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IS519_10645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IS519_10650	COG2104	thiamine diphosphate biosynthetic process
IS519_10655	COG2022	thiamine diphosphate biosynthetic process
IS519_10665	COG0006	proline dipeptidase activity
IS519_10695	COG3220	belongs to the UPF0276 family
IS519_10705	COG0210	DNA helicase
IS519_10715	COG0405	Gamma-glutamyltransferase
IS519_10720	COG1280	lysine exporter protein (LysE YggA)
IS519_10730	COG2962	Rard protein
IS519_10735	COG0514	ATP-dependent DNA helicase (RecQ)
IS519_10745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IS519_10750	COG0248	Ppx GppA phosphatase
IS519_10755	COG0513	Belongs to the DEAD box helicase family
IS519_10760	COG3118	belongs to the thioredoxin family
IS519_10775	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IS519_10780	COG2871	sodium ion transport
IS519_10835	COG3071	HemY protein
IS519_10840	COG2959	enzyme of heme biosynthesis
IS519_10845	COG1587	Uroporphyrinogen-III synthase
IS519_10850	COG0181	hydroxymethylbilane synthase activity
IS519_10860	COG1965	Belongs to the frataxin family
IS519_10870	COG0019	diaminopimelate decarboxylase activity
IS519_10875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IS519_10885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IS519_10890	COG1011	Hydrolase
IS519_10895	COG2199	diguanylate cyclase activity
IS519_10895	COG2200	EAL domain
IS519_10895	COG3287	FIST C domain
IS519_10900	COG2199	diguanylate cyclase activity
IS519_10900	COG2200	EAL domain
IS519_10900	COG3287	FIST C domain
IS519_10905	COG3148	PFAM DTW domain containing protein
IS519_10920	COG0561	phosphatase activity
IS519_10925	COG2267	carboxylic ester hydrolase activity
IS519_10930	COG1280	lysine exporter protein (LysE YggA)
IS519_10935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IS519_10940	COG0640	Transcriptional regulator
IS519_10945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS519_10985	COG2095	MarC family integral membrane protein
IS519_10995	COG0742	ribosomal rna small subunit methyltransferase
IS519_11000	COG0552	protein localization to endoplasmic reticulum
IS519_11005	COG2884	Cell division ATP-binding protein ftsE
IS519_11010	COG2177	Part of the ABC transporter FtsEX involved in
IS519_11020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS519_11025	COG0705	Rhomboid family
IS519_11030	COG1580	Controls the rotational direction of flagella during chemotaxis
IS519_11035	COG3161	chorismate lyase activity
IS519_11040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IS519_11045	COG2937	Belongs to the GPAT DAPAT family
IS519_11050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IS519_11055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IS519_11060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IS519_11065	COG0534	Mate efflux family protein
IS519_11070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS519_11120	COG0582	viral genome integration into host DNA
IS519_11135	COG2003	Belongs to the UPF0758 family
IS519_11165	COG0250	Participates in transcription elongation, termination and antitermination
IS519_11180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IS519_11185	COG4206	TonB-dependent receptor
IS519_11195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IS519_11280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS519_11290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IS519_11300	COG1072	(Pantothenic acid kinase))
IS519_11325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IS519_11330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IS519_11335	COG0250	Participates in transcription elongation, termination and antitermination
IS519_11345	COG0081	regulation of translation
IS519_11350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IS519_11355	COG0222	ribosome binding
IS519_11370	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IS519_11375	COG2816	NAD+ diphosphatase activity
IS519_11385	COG1573	uracil-dna glycosylase
IS519_11395	COG3068	Protein conserved in bacteria
IS519_11400	COG1253	flavin adenine dinucleotide binding
IS519_11415	COG0151	Belongs to the GarS family
IS519_11420	COG0138	bifunctional purine biosynthesis protein purh
IS519_11425	COG0789	Transcriptional regulator
IS519_11430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IS519_11435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS519_11440	COG2264	protein methyltransferase activity
IS519_11445	COG0439	Biotin carboxylase
IS519_11450	COG0511	ligase activity, forming carbon-carbon bonds
IS519_11455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IS519_11460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS519_11475	COG2814	Major facilitator Superfamily
IS519_11480	COG2198	Histidine kinase
IS519_11480	COG0784	Response regulator, receiver
IS519_11480	COG2205	protein histidine kinase activity
IS519_11495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_11505	COG3263	regulation of cellular component size
IS519_11515	COG4232	protein-disulfide reductase activity
IS519_11520	COG1438	arginine binding
IS519_11525	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IS519_11530	COG0540	Belongs to the ATCase OTCase family
IS519_11535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IS519_11540	COG0549	Belongs to the carbamate kinase family
IS519_11550	COG1288	antiporter activity
IS519_11555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS519_11560	COG1027	Aspartate ammonia-lyase
IS519_11570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IS519_11580	COG2205	protein histidine kinase activity
IS519_11585	COG0745	RESPONSE REGULATOR receiver
IS519_11595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IS519_11600	COG0205	6-phosphofructokinase activity
IS519_11605	COG0149	triose-phosphate isomerase activity
IS519_11615	COG3152	Membrane
IS519_11630	COG1494	fructose-1,6-bisphosphatase
IS519_11635	COG3074	FtsZ-dependent cytokinesis
IS519_11640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS519_11645	COG1575	Belongs to the MenA family. Type 1 subfamily
IS519_11650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IS519_11655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IS519_11665	COG1609	Transcriptional regulator
IS519_11670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IS519_11675	COG0254	rRNA binding
IS519_11680	COG0281	malic enzyme
IS519_11685	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IS519_11690	COG0626	cystathionine gamma-synthase activity
IS519_11695	COG0460	homoserine dehydrogenase
IS519_11695	COG0527	aspartate kinase activity
IS519_11700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IS519_11710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IS519_11715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS519_11720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IS519_11735	COG0165	Argininosuccinate lyase
IS519_11735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IS519_11745	COG0251	oxidation-reduction process
IS519_11750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS519_11755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IS519_11755	COG0678	peroxiredoxin activity
IS519_11765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IS519_11800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IS519_11810	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IS519_11815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IS519_11820	COG0546	phosphoglycolate phosphatase activity
IS519_11825	COG0180	Tryptophanyl-tRNA synthetase
IS519_11835	COG0512	Glutamine amidotransferase of anthranilate synthase
IS519_11840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IS519_11850	COG1012	belongs to the aldehyde dehydrogenase family
IS519_11860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS519_11865	COG3954	Phosphoribulokinase
IS519_11870	COG3089	Belongs to the UPF0270 family
IS519_11875	COG0429	hydrolase of the alpha beta-hydrolase fold
IS519_11885	COG0488	(ABC) transporter
IS519_11890	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS519_11905	COG1047	Peptidyl-prolyl cis-trans
IS519_11910	COG1446	asparaginase
IS519_11915	COG2900	Belongs to the SlyX family
IS519_11925	COG0545	Peptidyl-prolyl cis-trans isomerase
IS519_11930	COG2964	Protein conserved in bacteria
IS519_11935	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IS519_11940	COG2923	Belongs to the DsrF TusC family
IS519_11960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS519_11965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IS519_11975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IS519_11980	COG0088	Forms part of the polypeptide exit tunnel
IS519_11985	COG0089	rRNA binding
IS519_11990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IS519_11995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IS519_12005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IS519_12010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IS519_12020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IS519_12025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IS519_12030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IS519_12035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IS519_12040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IS519_12045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IS519_12050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IS519_12055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IS519_12060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IS519_12065	COG1841	ribosomal large subunit assembly
IS519_12070	COG0200	Binds to the 23S rRNA
IS519_12075	COG0201	protein transport
IS519_12080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IS519_12085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IS519_12090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IS519_12095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IS519_12100	COG0202	RNA polymerase activity
IS519_12105	COG0203	ribosomal protein L17
IS519_12115	COG0545	Peptidyl-prolyl cis-trans isomerase
IS519_12120	COG3061	Opacity-associated protein A
IS519_12120	COG3266	domain, Protein
IS519_12130	COG2153	protein acetylation
IS519_12180	COG0175	sulfate reduction
IS519_12185	COG2895	sulfate adenylyltransferase (ATP) activity
IS519_12190	COG3273	potassium ion transport
IS519_12190	COG0471	metal ion transport
IS519_12195	COG0529	Catalyzes the synthesis of activated sulfate
IS519_12230	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IS519_12240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IS519_12245	COG0729	surface antigen
IS519_12250	COG2911	Protein conserved in bacteria
IS519_12255	COG2105	PFAM AIG2 family protein
IS519_12260	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IS519_12265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IS519_12270	COG0163	prenyltransferase activity
IS519_12275	COG4143	(ABC) transporter
IS519_12280	COG1178	ABC-type Fe3 transport system permease component
IS519_12285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IS519_12290	COG3028	Belongs to the UPF0307 family
IS519_12295	COG0312	modulator of DNA gyrase
IS519_12300	COG2239	Acts as a magnesium transporter
IS519_12305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_12310	COG1660	Displays ATPase and GTPase activities
IS519_12315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_12320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IS519_12330	COG1137	ATPase activity
IS519_12335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IS519_12345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IS519_12350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IS519_12350	COG0517	IMP dehydrogenase activity
IS519_12360	COG1127	ABC transporter
IS519_12365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IS519_12370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IS519_12375	COG2854	intermembrane phospholipid transfer
IS519_12385	COG5007	Belongs to the BolA IbaG family
IS519_12390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IS519_12395	COG0204	Acyl-transferase
IS519_12400	COG0251	oxidation-reduction process
IS519_12405	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IS519_12435	COG0456	acetyltransferase
IS519_12445	COG0525	valine-tRNA ligase activity
IS519_12450	COG2927	DNA polymerase III (CHI subunit)
IS519_12455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IS519_12460	COG0795	lipopolysaccharide-transporting ATPase activity
IS519_12465	COG0795	lipopolysaccharide-transporting ATPase activity
IS519_12480	COG0582	viral genome integration into host DNA
IS519_12520	COG0582	viral genome integration into host DNA
IS519_12560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS519_12565	COG4974	Belongs to the 'phage' integrase family
IS519_12710	COG0741	lytic transglycosylase activity
IS519_12715	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IS519_12730	COG2066	Belongs to the glutaminase family
IS519_12735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IS519_12740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IS519_12755	COG0762	integral membrane protein
IS519_12760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IS519_12765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IS519_12785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IS519_12790	COG1678	Uncharacterized ACR, COG1678
IS519_12795	COG0189	ligase activity
IS519_12800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IS519_12805	COG2356	endonuclease I
IS519_12810	COG3091	SprT-like family
IS519_12820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IS519_12825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS519_12840	COG0191	fructose-bisphosphate aldolase activity
IS519_12845	COG0668	transmembrane transport
IS519_12850	COG1279	arginine transmembrane transporter activity
IS519_12865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS519_12870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IS519_12875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IS519_12885	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IS519_12890	COG3079	Belongs to the UPF0149 family
IS519_12895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS519_12900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IS519_12915	COG0354	folic acid binding
IS519_12920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IS519_12930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IS519_12935	COG1595	DNA-templated transcription, initiation
IS519_12955	COG0481	GTPase activity
IS519_12965	COG0571	ribonuclease III activity
IS519_12970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IS519_12975	COG1381	Involved in DNA repair and RecF pathway recombination
IS519_12980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IS519_12985	COG0736	holo-[acyl-carrier-protein] synthase activity
IS519_12990	COG2205	protein histidine kinase activity
IS519_12990	COG4999	Histidine kinase
IS519_12990	COG3850	Histidine kinase
IS519_12990	COG3437	response regulator, receiver
IS519_12995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IS519_13000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IS519_13005	COG3956	TIGRFAM MazG family protein
IS519_13010	COG0504	CTP synthase activity
IS519_13015	COG0148	phosphopyruvate hydratase activity
IS519_13020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IS519_13025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IS519_13035	COG0585	pseudouridine synthase activity
IS519_13040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IS519_13045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IS519_13055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IS519_13060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IS519_13080	COG1648	precorrin-2 dehydrogenase activity
IS519_13080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IS519_13085	COG1546	Belongs to the CinA family
IS519_13090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IS519_13100	COG0527	aspartate kinase activity
IS519_13155	COG3630	sodium ion export across plasma membrane
IS519_13160	COG0511	ligase activity, forming carbon-carbon bonds
IS519_13160	COG5016	pyruvate
IS519_13165	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IS519_13175	COG1238	metal cluster binding
IS519_13180	COG0612	Peptidase, M16
IS519_13195	COG1854	S-ribosylhomocysteine lyase activity
IS519_13200	COG4536	flavin adenine dinucleotide binding
IS519_13205	COG4137	Cytochrome C assembly protein
IS519_13210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IS519_13220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IS519_13225	COG0336	Belongs to the RNA methyltransferase TrmD family
IS519_13230	COG0335	large ribosomal subunit rRNA binding
IS519_13240	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IS519_13255	COG1459	type II secretion system
IS519_13260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IS519_13265	COG4969	Belongs to the N-Me-Phe pilin family
IS519_13270	COG0157	Belongs to the NadC ModD family
IS519_13280	COG2186	Transcriptional regulator
IS519_13285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IS519_13290	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS519_13295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IS519_13310	COG0288	reversible hydration of carbon dioxide
IS519_13315	COG0659	secondary active sulfate transmembrane transporter activity
IS519_13320	COG1131	(ABC) transporter
IS519_13325	COG0842	Transport permease protein
IS519_13330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IS519_13335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IS519_13340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS519_13360	COG1489	DNA binding
IS519_13385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS519_13395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS519_13405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_13415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS519_13420	COG4974	Belongs to the 'phage' integrase family
IS519_13430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IS519_13440	COG1643	Atp-dependent helicase
IS519_13455	COG1061	Type III restriction enzyme res subunit
IS519_13480	COG2433	Pfam Transposase IS66
IS519_13520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IS519_13525	COG1752	Esterase of the alpha-beta hydrolase superfamily
IS519_13530	COG1049	propionate catabolic process, 2-methylcitrate cycle
IS519_13545	COG0004	ammonium transporteR
IS519_13550	COG1840	ABC-type Fe3 transport system, periplasmic component
IS519_13560	COG3842	ATPase activity
IS519_13565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IS519_13580	COG2971	BadF BadG BcrA BcrD
IS519_13590	COG4608	Belongs to the ABC transporter superfamily
IS519_13595	COG0444	Belongs to the ABC transporter superfamily
IS519_13600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS519_13610	COG0747	negative chemotaxis
IS519_13620	COG2813	Specifically methylates the guanine in position
IS519_13625	COG0628	permease
IS519_13630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IS519_13635	COG0316	Belongs to the HesB IscA family
IS519_13650	COG0739	heme binding
IS519_13655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IS519_13660	COG2239	Acts as a magnesium transporter
IS519_13665	COG2027	D-alanyl-D-alanine carboxypeptidase
IS519_13670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS519_13675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IS519_13680	COG1534	Rna-binding protein
IS519_13685	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IS519_13690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IS519_13695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IS519_13700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IS519_13705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IS519_13720	COG0779	Required for maturation of 30S ribosomal subunits
IS519_13725	COG0195	Participates in both transcription termination and antitermination
IS519_13730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IS519_13735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IS519_13740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IS519_13745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IS519_13750	COG1185	polyribonucleotide nucleotidyltransferase activity
IS519_13765	COG0534	Mate efflux family protein
IS519_13770	COG0826	peptidase U32
IS519_13775	COG0826	peptidase U32
IS519_13785	COG3154	lipid carrier protein
IS519_13790	COG3153	acetyltransferase
IS519_13805	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IS519_13815	COG0084	hydrolase, TatD family'
IS519_13820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS519_13825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IS519_13830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IS519_13840	COG0813	purine-nucleoside phosphorylase activity
IS519_13850	COG0560	Phosphoserine phosphatase
IS519_13860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IS519_13865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IS519_13870	COG4628	conserved protein (DUF2132)
IS519_13875	COG0583	DNA-binding transcription factor activity
IS519_13885	COG0583	DNA-binding transcription factor activity
IS519_13890	COG1022	Amp-dependent synthetase and ligase
IS519_13920	COG4964	Belongs to the GSP D family
IS519_13980	COG2059	Chromate
IS519_13985	COG0583	DNA-binding transcription factor activity
IS519_13990	COG1609	Transcriptional regulator
IS519_14000	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_14005	COG0534	Mate efflux family protein
IS519_14010	COG3842	ATPase activity
IS519_14015	COG1175	transmembrane transport
IS519_14020	COG0395	ABC-type sugar transport system, permease component
IS519_14030	COG3250	beta-galactosidase activity
IS519_14035	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IS519_14035	COG3408	Glycogen debranching enzyme
IS519_14045	COG0531	amino acid
IS519_14050	COG0531	amino acid
IS519_14055	COG2731	YhcH YjgK YiaL family protein
IS519_14060	COG3250	beta-galactosidase activity
IS519_14065	COG1609	Transcriptional regulator
IS519_14070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IS519_14075	COG1085	galactose-1-phosphate uridylyltransferase
IS519_14085	COG2017	converts alpha-aldose to the beta-anomer
IS519_14090	COG1609	Transcriptional regulator
IS519_14095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS519_14110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IS519_14130	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS519_14135	COG2252	PERMEase
IS519_14140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IS519_14145	COG1073	alpha beta
IS519_14160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IS519_14165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IS519_14170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS519_14170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS519_14190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IS519_14195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IS519_14200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IS519_14205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IS519_14210	COG0142	geranyltranstransferase activity
IS519_14215	COG1722	exodeoxyribonuclease VII activity
IS519_14220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IS519_14230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IS519_14230	COG0301	tRNA thio-modification
IS519_14235	COG0583	DNA-binding transcription factor activity
IS519_14250	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IS519_14255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IS519_14260	COG1611	Belongs to the LOG family
IS519_14275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IS519_14275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IS519_14285	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IS519_14290	COG4580	involved in the transport of maltose and maltodextrins
IS519_14295	COG1464	Belongs to the NlpA lipoprotein family
IS519_14300	COG2011	ABC-type metal ion transport system permease component
IS519_14305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IS519_14310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IS519_14320	COG1609	Transcriptional regulator
IS519_14325	COG1263	PTS System
IS519_14325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS519_14330	COG0366	Alpha amylase catalytic
IS519_14375	COG0442	prolyl-tRNA aminoacylation
IS519_14380	COG1720	tRNA m6t6A37 methyltransferase activity
IS519_14385	COG0254	rRNA binding
IS519_14395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IS519_14415	COG1671	Belongs to the UPF0178 family
IS519_14440	COG3098	single-species biofilm formation
IS519_14445	COG0564	pseudouridine synthase activity
IS519_14455	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IS519_14460	COG0024	Methionine aminopeptidase
IS519_14465	COG0052	Belongs to the universal ribosomal protein uS2 family
IS519_14470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IS519_14475	COG0528	UMP kinase activity
IS519_14480	COG0233	cytoplasmic translational termination
IS519_14485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IS519_14490	COG0575	Belongs to the CDS family
IS519_14500	COG0750	zinc metalloprotease
IS519_14510	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IS519_14515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IS519_14520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IS519_14525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IS519_14535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IS519_14540	COG0587	DNA-directed DNA polymerase activity
IS519_14545	COG0825	malonyl-CoA metabolic process
IS519_14550	COG0037	tRNA processing
IS519_14560	COG0347	Belongs to the P(II) protein family
IS519_14565	COG3021	interspecies interaction between organisms
IS519_14575	COG1388	LysM domain
IS519_14575	COG0741	lytic transglycosylase activity
IS519_14580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IS519_14585	COG2226	methyltransferase
IS519_14590	COG0328	RNA-DNA hybrid ribonuclease activity
IS519_14595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IS519_14605	COG1960	acyl-CoA dehydrogenase activity
IS519_14610	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IS519_14615	COG0121	glutamine amidotransferase
IS519_14620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IS519_14625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IS519_14655	COG1393	Belongs to the ArsC family
IS519_14660	COG4783	chaperone-mediated protein folding
IS519_14675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IS519_14680	COG2716	regulation of RNA biosynthetic process
IS519_14685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IS519_14690	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IS519_14705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IS519_14710	COG1393	Belongs to the ArsC family
IS519_14715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IS519_14725	COG2003	Belongs to the UPF0758 family
IS519_14765	COG2837	iron assimilation
IS519_14770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IS519_14775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IS519_14780	COG2190	(PTS) system
IS519_14790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_14800	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IS519_14805	COG3115	cell septum assembly
IS519_14810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IS519_14830	COG0789	Transcriptional regulator
IS519_14840	COG0330	HflC and HflK could
IS519_14845	COG3118	belongs to the thioredoxin family
IS519_14850	COG0300	oxidoreductase activity
IS519_14855	COG1090	epimerase
IS519_14880	COG0622	Phosphoesterase
IS519_14895	COG3710	Transcriptional regulator
IS519_14900	COG0326	Molecular chaperone. Has ATPase activity
IS519_14905	COG0563	adenylate kinase activity
IS519_14910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IS519_14915	COG3104	oligopeptide transport
IS519_14920	COG0250	Participates in transcription elongation, termination and antitermination
IS519_14925	COG0367	asparagine synthase
IS519_14930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IS519_14930	COG4651	solute:proton antiporter activity
IS519_14935	COG1846	Transcriptional regulator
IS519_14935	COG1940	carbohydrate kinase activity
IS519_14940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IS519_14945	COG2190	(PTS) system
IS519_14945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS519_14945	COG1263	PTS System
IS519_14950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IS519_14975	COG0596	Alpha beta hydrolase
IS519_14980	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IS519_14985	COG0033	Phosphoglucomutase
IS519_14995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IS519_15010	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IS519_15015	COG1053	succinate dehydrogenase
IS519_15020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IS519_15025	COG0567	Dehydrogenase, E1 component
IS519_15030	COG0508	dehydrogenase complex catalyzes the overall conversion of
IS519_15035	COG0045	succinate-CoA ligase (ADP-forming) activity
IS519_15045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS519_15050	COG1121	(ABC) transporter
IS519_15055	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IS519_15065	COG1918	ferrous iron import across plasma membrane
IS519_15085	COG0018	arginyl-trna synthetase
IS519_15090	COG3102	Protein conserved in bacteria
IS519_15095	COG0788	formyltetrahydrofolate deformylase activity
IS519_15105	COG1199	ATP-dependent helicase activity
IS519_15110	COG1214	PFAM Peptidase M22, glycoprotease
IS519_15120	COG3065	identical protein binding
IS519_15125	COG0596	Alpha beta hydrolase
IS519_15130	COG0318	PFAM AMP-dependent synthetase and ligase
IS519_15135	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IS519_15140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IS519_15145	COG2894	cell division
IS519_15150	COG0850	regulation of cytokinetic process
IS519_15155	COG3100	YcgL domain-containing protein
IS519_15160	COG2951	lytic endotransglycosylase activity
IS519_15165	COG0583	DNA-binding transcription factor activity
IS519_15170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS519_15180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IS519_15195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IS519_15200	COG2860	membrane
IS519_15205	COG3101	peptidyl-lysine hydroxylation
IS519_15225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IS519_15230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IS519_15235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS519_15245	COG0101	tRNA pseudouridine synthase activity
IS519_15250	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IS519_15255	COG0285	dihydrofolate synthase activity
IS519_15260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IS519_15265	COG1286	toxin biosynthetic process
IS519_15270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IS519_15275	COG0583	DNA-binding transcription factor activity
IS519_15280	COG0745	RESPONSE REGULATOR receiver
IS519_15290	COG2832	Protein of unknown function (DUF454)
IS519_15295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IS519_15300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IS519_15305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IS519_15310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IS519_15325	COG2983	Belongs to the UPF0260 family
IS519_15345	COG2226	methyltransferase
IS519_15360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IS519_15365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IS519_15375	COG3139	Protein of unknown function (DUF1315)
IS519_15380	COG0252	asparaginase activity
IS519_15385	COG0616	signal peptide processing
IS519_15390	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS519_15390	COG1902	pentaerythritol trinitrate reductase activity
IS519_15395	COG0778	Nitroreductase
IS519_15400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS519_15415	COG0123	including yeast histone deacetylase and acetoin utilization protein
IS519_15435	COG3082	Protein of unknown function (DUF1414)
IS519_15440	COG3081	Nucleoid-associated protein
IS519_15455	COG1757	Na H antiporter
IS519_15460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IS519_15470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IS519_15475	COG2095	MarC family integral membrane protein
IS519_15480	COG1012	belongs to the aldehyde dehydrogenase family
IS519_15480	COG1454	alcohol dehydrogenase
IS519_15500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IS519_15510	COG2056	Na+-H+ antiporter family
IS519_15530	COG0346	lactoylglutathione lyase activity
IS519_15540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IS519_15545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IS519_15550	COG4660	Part of a membrane complex involved in electron transport
IS519_15555	COG4659	FMN binding
IS519_15560	COG4658	electron transport chain
IS519_15565	COG4656	Part of a membrane complex involved in electron transport
IS519_15570	COG2878	Part of a membrane complex involved in electron transport
IS519_15575	COG4657	Part of a membrane complex involved in electron transport
IS519_15585	COG0556	nucleotide-excision repair
IS519_15590	COG2204	response regulator
IS519_15595	COG2198	Histidine kinase
IS519_15600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IS519_15605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IS519_15610	COG0521	Mo-molybdopterin cofactor biosynthetic process
IS519_15615	COG0315	cyclic pyranopterin monophosphate synthase activity
IS519_15620	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IS519_15625	COG0314	molybdopterin synthase activity
IS519_15635	COG0601	transmembrane transport
IS519_15640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS519_15645	COG0444	Belongs to the ABC transporter superfamily
IS519_15655	COG0435	Glutathione S-transferase
IS519_15660	COG0280	phosphate acetyltransferase
IS519_15660	COG0857	belongs to the CobB CobQ family
IS519_15665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IS519_15670	COG3092	negative regulation of chromosome organization
IS519_15680	COG0366	Alpha amylase catalytic
IS519_15685	COG3706	GGDEF domain
IS519_15690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IS519_15695	COG0653	protein targeting
IS519_15705	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IS519_15710	COG2186	Transcriptional regulator
IS519_15720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS519_15720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IS519_15725	COG0489	protein tyrosine kinase activity
IS519_15730	COG0572	uridine kinase
IS519_15735	COG2982	Protein involved in outer membrane biogenesis
IS519_15740	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IS519_15745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IS519_15750	COG0659	secondary active sulfate transmembrane transporter activity
IS519_15755	COG1530	ribonuclease E activity
IS519_15760	COG0564	pseudouridine synthase activity
IS519_15770	COG1399	metal-binding, possibly nucleic acid-binding protein
IS519_15775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IS519_15780	COG0416	fatty acid biosynthetic process
IS519_15785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IS519_15810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IS519_15815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IS519_15825	COG0470	DNA polymerase III
IS519_15830	COG0084	hydrolase, TatD family'
IS519_15855	COG4667	esterase of the alpha-beta hydrolase superfamily
IS519_15860	COG0469	pyruvate kinase activity
IS519_15865	COG1940	carbohydrate kinase activity
IS519_15870	COG0835	chemotaxis
IS519_15870	COG0784	Response regulator, receiver
IS519_15880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IS519_15885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IS519_15890	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_15895	COG0616	signal peptide processing
IS519_15900	COG2719	SpoVR family
IS519_15905	COG2718	Belongs to the UPF0229 family
IS519_15910	COG2766	serine protein kinase
IS519_15925	COG3013	Belongs to the UPF0304 family
IS519_15930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS519_15940	COG1882	Formate acetyltransferase
IS519_15970	COG4160	amino acid transport
IS519_15975	COG0708	Exodeoxyribonuclease III
IS519_15980	COG1770	oligopeptidase
IS519_15985	COG2814	Major facilitator Superfamily
IS519_15995	COG2850	peptidyl-arginine hydroxylation
IS519_16015	COG1199	ATP-dependent helicase activity
IS519_16025	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IS519_16030	COG1187	pseudouridine synthase activity
IS519_16040	COG1278	Cold shock
IS519_16045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IS519_16050	COG0542	response to heat
IS519_16055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IS519_16060	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IS519_16065	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IS519_16075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IS519_16085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IS519_16090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IS519_16095	COG0297	glycogen (starch) synthase activity
IS519_16120	COG3070	regulator of competence-specific genes
IS519_16125	COG1609	Transcriptional regulator
IS519_16130	COG3381	protein complex oligomerization
IS519_16135	COG0745	RESPONSE REGULATOR receiver
IS519_16140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IS519_16145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IS519_16150	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
IS519_16155	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IS519_16160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IS519_16165	COG3383	formate dehydrogenase (NAD+) activity
IS519_16180	COG4067	protein conserved in archaea
IS519_16180	COG0189	ligase activity
IS519_16185	COG0500	methyltransferase
IS519_16190	COG4106	trans-aconitate 2-methyltransferase activity
IS519_16195	COG1801	Protein of unknown function DUF72
IS519_16200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IS519_16205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IS519_16210	COG0840	transmembrane signaling receptor activity
IS519_16215	COG0632	four-way junction helicase activity
IS519_16220	COG2255	four-way junction helicase activity
IS519_16225	COG1271	oxidase subunit
IS519_16230	COG1294	oxidase, subunit
IS519_16235	COG4890	Cyd operon protein YbgT
IS519_16245	COG0824	Thioesterase
IS519_16250	COG0811	peptide transport
IS519_16265	COG0823	Involved in the tonB-independent uptake of proteins
IS519_16270	COG2885	chlorophyll binding
IS519_16275	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IS519_16280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IS519_16295	COG5002	protein histidine kinase activity
IS519_16295	COG0784	Response regulator, receiver
IS519_16310	COG0786	glutamate:sodium symporter activity
IS519_16335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IS519_16345	COG0583	DNA-binding transcription factor activity
IS519_16350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS519_16370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IS519_16375	COG0444	Belongs to the ABC transporter superfamily
IS519_16380	COG4608	Belongs to the ABC transporter superfamily
IS519_16390	COG1609	Transcriptional regulator
IS519_16400	COG4580	involved in the transport of maltose and maltodextrins
IS519_16410	COG1472	Belongs to the glycosyl hydrolase 3 family
IS519_16435	COG0745	RESPONSE REGULATOR receiver
IS519_16440	COG0463	Glycosyl transferase, family 2
IS519_16455	COG1032	radical SAM domain protein
IS519_16470	COG0583	DNA-binding transcription factor activity
IS519_16500	COG0646	methionine synthase
IS519_16500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IS519_16520	COG0604	alcohol dehydrogenase
IS519_16520	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_16520	COG3321	synthase
IS519_16545	COG1312	Catalyzes the dehydration of D-mannonate
IS519_16550	COG2186	Transcriptional regulator
IS519_16560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IS519_16570	COG0246	Mannitol dehydrogenase
IS519_16575	COG1904	glucuronate isomerase
IS519_16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_16585	COG0800	Aldolase
IS519_16615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IS519_16620	COG0110	maltose O-acetyltransferase activity
IS519_16635	COG2207	Transcriptional regulator
IS519_16650	COG3408	Glycogen debranching enzyme
IS519_16650	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IS519_16655	COG2188	Transcriptional regulator
IS519_16670	COG1263	PTS System
IS519_16670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS519_16675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_16680	COG0800	Aldolase
IS519_16685	COG2169	Transcriptional regulator
IS519_16690	COG1486	melibiose metabolic process
IS519_16695	COG2211	Major facilitator Superfamily
IS519_16705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IS519_16710	COG1072	(Pantothenic acid kinase))
IS519_16715	COG3722	fumarate hydratase activity
IS519_16720	COG1063	alcohol dehydrogenase
IS519_16725	COG2213	PTS system mannitol-specific
IS519_16730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_16735	COG0456	acetyltransferase
IS519_16745	COG1309	transcriptional regulator
IS519_16780	COG1846	Transcriptional regulator
IS519_16785	COG4175	Glycine betaine
IS519_16805	COG1012	belongs to the aldehyde dehydrogenase family
IS519_16810	COG1309	transcriptional regulator
IS519_16830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IS519_16840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IS519_16845	COG1473	amidohydrolase
IS519_16855	COG1522	sequence-specific DNA binding
IS519_16870	COG0745	RESPONSE REGULATOR receiver
IS519_16875	COG2205	protein histidine kinase activity
IS519_16895	COG0579	oxidoreductase
IS519_16910	COG2204	response regulator
IS519_16915	COG3852	Histidine kinase
IS519_16925	COG0800	Aldolase
IS519_16930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_16935	COG4145	pantothenate transmembrane transporter activity
IS519_16945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IS519_16980	COG2194	sulfuric ester hydrolase activity
IS519_16990	COG1360	Flagellar Motor Protein
IS519_16995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IS519_17000	COG1191	sigma factor activity
IS519_17025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IS519_17030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IS519_17070	COG1677	Flagellar hook-basal body complex protein FliE
IS519_17075	COG2885	chlorophyll binding
IS519_17085	COG1256	bacterial-type flagellum assembly
IS519_17085	COG4786	Flagellar basal body rod
IS519_17095	COG1706	bacterial-type flagellum-dependent cell motility
IS519_17100	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IS519_17105	COG4786	Flagellar basal body rod
IS519_17110	COG4786	Flagellar basal body rod
IS519_17115	COG1749	Flagellar hook protein flgE
IS519_17125	COG1558	bacterial-type flagellum-dependent cell motility
IS519_17130	COG1815	bacterial-type flagellum-dependent cell motility
IS519_17140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IS519_17150	COG1987	bacterial-type flagellum assembly
IS519_17185	COG1132	(ABC) transporter
IS519_17215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_17240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IS519_17250	COG0259	pyridoxamine-phosphate oxidase activity
IS519_17290	COG1444	tRNA N-acetyltransferase activity
IS519_17315	COG4608	Belongs to the ABC transporter superfamily
IS519_17320	COG0444	Belongs to the ABC transporter superfamily
IS519_17330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IS519_17330	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
IS519_17345	COG4221	oxidoreductase activity
IS519_17355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS519_17360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS519_17375	COG0765	amino acid transport
IS519_17410	COG3842	ATPase activity
IS519_17425	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IS519_17435	COG0625	glutathione transferase activity
IS519_17445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IS519_17450	COG3186	Phenylalanine-4-hydroxylase
IS519_17465	COG0217	transcriptional regulatory protein
IS519_17480	COG2084	Dehydrogenase
IS519_17490	COG1621	beta-fructofuranosidase activity
IS519_17500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_17505	COG1072	(Pantothenic acid kinase))
IS519_17525	COG4591	ABC-type transport system involved in lipoprotein release permease component
IS519_17540	COG3275	phosphorelay sensor kinase activity
IS519_17545	COG3279	Response regulator of the LytR AlgR family
IS519_17550	COG0612	Peptidase, M16
IS519_17555	COG0612	Peptidase, M16
IS519_17565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS519_17570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS519_17585	COG1902	pentaerythritol trinitrate reductase activity
IS519_17590	COG2814	Major facilitator Superfamily
IS519_17595	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_17615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS519_17625	COG0724	RNA recognition motif
IS519_17630	COG4221	oxidoreductase activity
IS519_17655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IS519_17670	COG4221	oxidoreductase activity
IS519_17680	COG0415	Belongs to the DNA photolyase family
IS519_17690	COG3806	Anti-sigma factor
IS519_17695	COG1595	DNA-templated transcription, initiation
IS519_17705	COG1942	4-Oxalocrotonate Tautomerase
IS519_17720	COG0786	glutamate:sodium symporter activity
IS519_17725	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS519_17750	COG2213	PTS system mannitol-specific
IS519_17750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_17755	COG0246	Mannitol dehydrogenase
IS519_17760	COG3722	fumarate hydratase activity
IS519_17765	COG0363	glucosamine-6-phosphate deaminase activity
IS519_17785	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IS519_17790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IS519_17800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IS519_17810	COG3366	ferrous iron transmembrane transporter activity
IS519_17815	COG0700	Nucleoside recognition
IS519_17820	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IS519_17865	COG0596	Alpha beta hydrolase
IS519_17880	COG3123	guanosine phosphorylase activity
IS519_17885	COG1741	Belongs to the pirin family
IS519_17905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IS519_17920	COG0346	lactoylglutathione lyase activity
IS519_17930	COG2723	6-phospho-beta-galactosidase activity
IS519_17935	COG1609	Transcriptional regulator
IS519_17940	COG0110	maltose O-acetyltransferase activity
IS519_17945	COG0583	DNA-binding transcription factor activity
IS519_17975	COG2197	response regulator
IS519_17985	COG2814	Major facilitator Superfamily
IS519_17990	COG0583	DNA-binding transcription factor activity
IS519_17995	COG0641	radical SAM
IS519_18000	COG3119	arylsulfatase activity
IS519_18025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IS519_18035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IS519_18055	COG0641	radical SAM
IS519_18060	COG0583	DNA-binding transcription factor activity
IS519_18065	COG3119	arylsulfatase activity
IS519_18090	COG0549	Belongs to the carbamate kinase family
IS519_18095	COG0531	amino acid
IS519_18100	COG2957	Belongs to the agmatine deiminase family
IS519_18140	COG0583	DNA-binding transcription factor activity
IS519_18145	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_18150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IS519_18155	COG1349	DNA-binding transcription factor activity
IS519_18160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IS519_18165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IS519_18185	COG2828	Protein conserved in bacteria
IS519_18210	COG0583	DNA-binding transcription factor activity
IS519_18215	COG0798	PFAM Bile acid sodium symporter
IS519_18230	COG1309	transcriptional regulator
IS519_18235	COG0561	phosphatase activity
IS519_18250	COG0583	DNA-binding transcription factor activity
IS519_18290	COG1349	DNA-binding transcription factor activity
IS519_18295	COG2084	Dehydrogenase
IS519_18300	COG3395	kinase activity
IS519_18305	COG0235	Class ii aldolase
IS519_18310	COG3622	Belongs to the hyi family
IS519_18315	COG2610	gluconate transmembrane transporter activity
IS519_18320	COG1929	Belongs to the glycerate kinase type-1 family
IS519_18325	COG0753	catalase activity
IS519_18330	COG4667	esterase of the alpha-beta hydrolase superfamily
IS519_18335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IS519_18345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS519_18350	COG0204	Acyl-transferase
IS519_18355	COG2384	SAM-dependent methyltransferase
IS519_18370	COG4580	involved in the transport of maltose and maltodextrins
IS519_18410	COG3258	Cytochrome c
IS519_18440	COG4566	intracellular signal transduction
IS519_18450	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IS519_18455	COG1162	GTPase activity
IS519_18465	COG1999	signal sequence binding
IS519_18480	COG2909	trisaccharide binding
IS519_18485	COG0058	SHG alpha-glucan phosphorylase activity
IS519_18490	COG1640	4-alpha-glucanotransferase
IS519_18495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IS519_18510	COG1122	ATPase activity
IS519_18515	COG4720	Psort location CytoplasmicMembrane, score
IS519_18520	COG1566	PFAM secretion protein HlyD family protein
IS519_18550	COG0813	purine-nucleoside phosphorylase activity
IS519_18555	COG1376	ErfK ybiS ycfS ynhG family protein
IS519_18555	COG1388	LysM domain
IS519_18565	COG0513	Belongs to the DEAD box helicase family
IS519_18575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IS519_18585	COG0840	transmembrane signaling receptor activity
IS519_18595	COG0573	inorganic phosphate transmembrane transporter activity
IS519_18600	COG0581	inorganic phosphate transmembrane transporter activity
IS519_18605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS519_18620	COG2304	oxidoreductase activity
IS519_18625	COG2304	oxidoreductase activity
IS519_18640	COG0714	Associated with various cellular activities
IS519_18660	COG0840	transmembrane signaling receptor activity
IS519_18670	COG3842	ATPase activity
IS519_18680	COG1175	transmembrane transport
IS519_18685	COG3833	ABC-type maltose transport systems, permease component
IS519_18730	COG0668	transmembrane transport
IS519_18735	COG0583	DNA-binding transcription factor activity
IS519_18755	COG2239	Acts as a magnesium transporter
IS519_18765	COG0387	Pfam Sodium calcium exchanger
IS519_18770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS519_18775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IS519_18785	COG2356	endonuclease I
IS519_18795	COG0577	efflux transmembrane transporter activity
IS519_18800	COG1136	(ABC) transporter
IS519_18810	COG0737	Belongs to the 5'-nucleotidase family
IS519_18845	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_18870	COG0583	DNA-binding transcription factor activity
IS519_18915	COG1012	belongs to the aldehyde dehydrogenase family
IS519_18920	COG1414	Transcriptional regulator
IS519_18930	COG0730	response to heat
IS519_18960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS519_18965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IS519_18970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IS519_18975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IS519_18975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IS519_18990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS519_19000	COG2354	Protein conserved in bacteria
IS519_19005	COG0418	dihydroorotase activity
IS519_19015	COG3217	Mosc domain protein beta barrel domain protein
IS519_19015	COG0633	Ferredoxin
IS519_19020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IS519_19065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IS519_19070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS519_19080	COG0848	biopolymer transport protein
IS519_19085	COG0811	peptide transport
IS519_19090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IS519_19100	COG3721	Heme iron utilization protein
IS519_19105	COG0748	coenzyme F420 binding
IS519_19110	COG2096	Adenosyltransferase
IS519_19115	COG0784	Response regulator, receiver
IS519_19115	COG0835	chemotaxis
IS519_19120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IS519_19125	COG0366	Alpha amylase catalytic
IS519_19135	COG3314	Sporulation integral membrane protein YlbJ
IS519_19160	COG0739	heme binding
IS519_19165	COG5001	Diguanylate cyclase
IS519_19170	COG0583	DNA-binding transcription factor activity
IS519_19175	COG2814	Major facilitator Superfamily
IS519_19190	COG0697	spore germination
IS519_19195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IS519_19210	COG3118	belongs to the thioredoxin family
IS519_19215	COG4232	protein-disulfide reductase activity
IS519_19230	COG0668	transmembrane transport
IS519_19280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_19285	COG1538	Outer membrane efflux protein
IS519_19305	COG4989	oxidoreductase activity
IS519_19310	COG0513	Belongs to the DEAD box helicase family
IS519_19325	COG2176	DNA-directed DNA polymerase activity
IS519_19335	COG0513	Belongs to the DEAD box helicase family
IS519_19340	COG0778	Nitroreductase
IS519_19355	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IS519_19360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IS519_19365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IS519_19370	COG0667	Aldo Keto reductase
IS519_19380	COG2195	Cleaves the N-terminal amino acid of tripeptides
IS519_19415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS519_19430	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IS519_19435	COG0513	Belongs to the DEAD box helicase family
IS519_19440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IS519_19460	COG1396	sequence-specific DNA binding
IS519_19465	COG3135	benzoate transporter
IS519_19505	COG0019	diaminopimelate decarboxylase activity
IS519_19510	COG4264	IucA IucC family
IS519_19535	COG4772	TonB-dependent receptor
IS519_19540	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IS519_19545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS519_19550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS519_19555	COG1120	ATPase activity
IS519_19575	COG0366	Alpha amylase catalytic
IS519_19585	COG0583	DNA-binding transcription factor activity
IS519_19590	COG0534	Mate efflux family protein
IS519_19600	COG2963	transposase activity
IS519_19625	COG0516	GMP reductase activity
IS519_19640	COG3710	Transcriptional regulator
IS519_19675	COG0697	spore germination
IS519_19680	COG0351	phosphomethylpyrimidine kinase
IS519_19685	COG1116	anion transmembrane transporter activity
IS519_19690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IS519_19695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IS519_19700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IS519_19705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IS519_19715	COG0352	thiamine-phosphate diphosphorylase activity
IS519_19725	COG0583	DNA-binding transcription factor activity
IS519_19740	COG0402	S-adenosylhomocysteine deaminase activity
IS519_19765	COG3706	GGDEF domain
IS519_19775	COG1566	PFAM secretion protein HlyD family protein
IS519_19785	COG0628	permease
IS519_19805	COG0668	transmembrane transport
IS519_19810	COG0569	domain protein
IS519_19815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IS519_19820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IS519_19820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IS519_19825	COG1765	OsmC-like protein
IS519_19830	COG2885	chlorophyll binding
IS519_19840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IS519_19850	COG1840	ABC-type Fe3 transport system, periplasmic component
IS519_19855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IS519_19860	COG3842	ATPase activity
IS519_19885	COG3104	oligopeptide transport
IS519_19895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IS519_19915	COG5001	Diguanylate cyclase
IS519_19915	COG4251	negative regulation of phosphorylation
IS519_19915	COG2203	Gaf domain
IS519_19915	COG3706	GGDEF domain
IS519_19920	COG2897	thiosulfate sulfurtransferase activity
IS519_19950	COG0302	gtp cyclohydrolase
IS519_19960	COG4681	YaeQ
IS519_19965	COG1278	Cold shock
IS519_19970	COG2133	pyrroloquinoline quinone binding
IS519_19980	COG1120	ATPase activity
IS519_19995	COG4774	siderophore transport
IS519_20000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS519_20005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS519_20010	COG1024	Enoyl-CoA hydratase
IS519_20030	COG2985	domain, Protein
IS519_20040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_20045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS519_20060	COG3710	Transcriptional regulator
IS519_20070	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS519_20070	COG1902	pentaerythritol trinitrate reductase activity
IS519_20085	COG1132	(ABC) transporter
IS519_20110	COG0427	acetyl-CoA hydrolase
IS519_20115	COG1024	Enoyl-CoA hydratase
IS519_20115	COG1250	3-hydroxyacyl-CoA dehydrogenase
IS519_20120	COG0183	Belongs to the thiolase family
IS519_20135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_20140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS519_20180	COG2824	Alkylphosphonate utilization operon protein PhnA
IS519_20225	COG0765	amino acid transport
IS519_20235	COG0765	amino acid transport
IS519_20240	COG1126	abc transporter atp-binding protein
IS519_20245	COG1979	alcohol dehydrogenase
IS519_20250	COG2207	Transcriptional regulator
IS519_20280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IS519_20295	COG3059	membrane
IS519_20305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS519_20315	COG3706	GGDEF domain
IS519_20330	COG1686	Belongs to the peptidase S11 family
IS519_20340	COG0583	DNA-binding transcription factor activity
IS519_20350	COG0564	pseudouridine synthase activity
IS519_20360	COG2130	NADP-dependent
IS519_20365	COG1309	transcriptional regulator
IS519_20370	COG0545	Peptidyl-prolyl cis-trans isomerase
IS519_20390	COG3604	Transcriptional regulator
IS519_20395	COG1017	nitric oxide dioxygenase activity
IS519_20395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS519_20400	COG1609	Transcriptional regulator
IS519_20410	COG1175	transmembrane transport
IS519_20415	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IS519_20425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IS519_20435	COG0038	chloride channel
IS519_20440	COG0523	cobalamin synthesis protein
IS519_20445	COG0513	Belongs to the DEAD box helicase family
IS519_20505	COG0745	RESPONSE REGULATOR receiver
IS519_20550	COG0183	Belongs to the thiolase family
IS519_20565	COG2963	transposase activity
IS519_20580	COG3005	denitrification pathway
IS519_20590	COG0243	molybdopterin cofactor binding
IS519_20605	COG3850	Histidine kinase
IS519_20610	COG2197	response regulator
IS519_20615	COG3069	C4-dicarboxylate transmembrane transporter activity
IS519_20630	COG2267	carboxylic ester hydrolase activity
IS519_20635	COG2067	long-chain fatty acid transport protein
IS519_20640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_20645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IS519_20670	COG2188	Transcriptional regulator
IS519_20675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_20675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_20675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_20680	COG0383	alpha-mannosidase activity
IS519_20685	COG1929	Belongs to the glycerate kinase type-1 family
IS519_20705	COG0583	DNA-binding transcription factor activity
IS519_20720	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IS519_20730	COG1280	lysine exporter protein (LysE YggA)
IS519_20760	COG2304	oxidoreductase activity
IS519_20780	COG0714	Associated with various cellular activities
IS519_20790	COG0534	Mate efflux family protein
IS519_20805	COG0509	glycine decarboxylation via glycine cleavage system
IS519_20845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS519_20855	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IS519_20860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_20875	COG0784	Response regulator, receiver
IS519_20875	COG3437	response regulator, receiver
IS519_20880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS519_20890	COG0814	amino acid
IS519_20895	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IS519_20900	COG0513	Belongs to the DEAD box helicase family
IS519_20925	COG2200	EAL domain
IS519_20940	COG3038	cytochrome b561
IS519_20945	COG2353	YceI-like domain
IS519_20950	COG2116	formate transmembrane transporter activity
IS519_20955	COG0583	DNA-binding transcription factor activity
IS519_20965	COG3593	DNA synthesis involved in DNA repair
IS519_20970	COG0737	Belongs to the 5'-nucleotidase family
IS519_20975	COG0861	Integral membrane protein TerC family
IS519_20990	COG0513	Belongs to the DEAD box helicase family
IS519_21010	COG0583	DNA-binding transcription factor activity
IS519_21020	COG2267	carboxylic ester hydrolase activity
IS519_21025	COG2067	long-chain fatty acid transport protein
IS519_21035	COG0501	Belongs to the peptidase M48B family
IS519_21040	COG2050	protein possibly involved in aromatic compounds catabolism
IS519_21050	COG4533	DNA binding
IS519_21090	COG3706	GGDEF domain
IS519_21115	COG2207	Transcriptional regulator
IS519_21120	COG0076	glutamate decarboxylase activity
IS519_21130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IS519_21170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IS519_21175	COG0494	nUDIX hydrolase
IS519_21245	COG0768	penicillin binding
IS519_21255	COG1716	ATPase activity
IS519_21255	COG5001	Diguanylate cyclase
IS519_21260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IS519_21270	COG4181	ATPase activity
IS519_21275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IS519_21285	COG1984	allophanate hydrolase subunit 2
IS519_21310	COG3300	MHYT domain
IS519_21310	COG5001	Diguanylate cyclase
IS519_21320	COG4771	TonB-dependent receptor
IS519_21320	COG1629	transport
IS519_21325	COG0583	DNA-binding transcription factor activity
IS519_21330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS519_21330	COG1042	CoA-binding domain protein
IS519_21330	COG0045	succinate-CoA ligase (ADP-forming) activity
IS519_21335	COG3266	domain, Protein
IS519_21340	COG1181	Belongs to the D-alanine--D-alanine ligase family
IS519_21355	COG0023	Translation Initiation Factor
IS519_21360	COG3706	GGDEF domain
IS519_21365	COG3140	Belongs to the UPF0181 family
IS519_21390	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IS519_21395	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IS519_21410	COG3706	GGDEF domain
IS519_21420	COG2203	Gaf domain
IS519_21420	COG5001	Diguanylate cyclase
IS519_21420	COG4251	negative regulation of phosphorylation
IS519_21420	COG3706	GGDEF domain
IS519_21430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IS519_21435	COG4149	molybdate abc transporter
IS519_21440	COG0725	ABC transporter, periplasmic molybdate-binding protein
IS519_21640	COG2226	methyltransferase
IS519_21650	COG1475	DNA binding
IS519_21690	COG1484	DNA-dependent DNA replication
IS519_21775	COG0488	(ABC) transporter
IS519_21780	COG4067	protein conserved in archaea
IS519_21780	COG0189	ligase activity
IS519_21800	COG0602	queuosine metabolic process
IS519_21805	COG1328	CTP reductase activity
IS519_21835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IS519_21840	COG3118	belongs to the thioredoxin family
IS519_21850	COG0318	PFAM AMP-dependent synthetase and ligase
IS519_21885	COG0534	Mate efflux family protein
IS519_21910	COG1321	iron dependent repressor
IS519_21910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IS519_21915	COG1121	(ABC) transporter
IS519_21920	COG0803	Belongs to the bacterial solute-binding protein 9 family
IS519_21965	COG0848	biopolymer transport protein
IS519_21970	COG0811	peptide transport
IS519_21975	COG0811	peptide transport
IS519_21985	COG4774	siderophore transport
IS519_21990	COG1301	dicarboxylic acid transport
IS519_21995	COG2205	protein histidine kinase activity
IS519_22000	COG0745	RESPONSE REGULATOR receiver
IS519_22015	COG1648	precorrin-2 dehydrogenase activity
IS519_22015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IS519_22020	COG2116	formate transmembrane transporter activity
IS519_22030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS519_22070	COG2807	transmembrane transport
IS519_22080	COG1881	PFAM PEBP family protein
IS519_22085	COG5002	protein histidine kinase activity
IS519_22150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_22155	COG2205	protein histidine kinase activity
IS519_22155	COG0784	Response regulator, receiver
IS519_22160	COG1538	Outer membrane efflux protein
IS519_22165	COG1132	(ABC) transporter
IS519_22195	COG0405	Gamma-glutamyltransferase
IS519_22205	COG0641	radical SAM
IS519_22230	COG3300	MHYT domain
IS519_22230	COG5001	Diguanylate cyclase
IS519_22240	COG0583	DNA-binding transcription factor activity
IS519_22270	COG0714	Associated with various cellular activities
IS519_22280	COG3119	arylsulfatase activity
IS519_22285	COG3119	arylsulfatase activity
IS519_22295	COG2205	protein histidine kinase activity
IS519_22295	COG0784	Response regulator, receiver
IS519_22305	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IS519_22330	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IS519_22355	COG0384	phenazine biosynthesis protein PhzF
IS519_22365	COG5001	Diguanylate cyclase
IS519_22365	COG3300	MHYT domain
IS519_22385	COG3278	Belongs to the heme-copper respiratory oxidase family
IS519_22425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IS519_22435	COG1012	belongs to the aldehyde dehydrogenase family
IS519_22445	COG0583	DNA-binding transcription factor activity
IS519_22455	COG0356	it plays a direct role in the translocation of protons across the membrane
IS519_22470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IS519_22480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IS519_22490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IS519_22500	COG0583	DNA-binding transcription factor activity
IS519_22510	COG3038	cytochrome b561
IS519_22530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IS519_22540	COG1609	Transcriptional regulator
IS519_22555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_22575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IS519_22580	COG1538	Outer membrane efflux protein
IS519_22620	COG1228	amidohydrolase
IS519_22635	COG4172	Belongs to the ABC transporter superfamily
IS519_22640	COG4239	(ABC) transporter, permease
IS519_22645	COG4174	ABC transporter (Permease)
IS519_22650	COG4166	transmembrane transport
IS519_22670	COG1869	D-ribose catabolic process
IS519_22675	COG1129	ABC transporter
IS519_22680	COG1172	Belongs to the binding-protein-dependent transport system permease family
IS519_22685	COG1879	ABC-type sugar transport system periplasmic component
IS519_22690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_22695	COG1609	Transcriptional regulator
IS519_22730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS519_22735	COG0789	Transcriptional regulator
IS519_22770	COG0243	molybdopterin cofactor binding
IS519_22775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IS519_22785	COG2223	nitrite transmembrane transporter activity
IS519_22790	COG2815	serine threonine protein kinase
IS519_22790	COG0515	serine threonine protein kinase
IS519_22795	COG1609	Transcriptional regulator
IS519_22800	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_22800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_22805	COG1105	Belongs to the carbohydrate kinase PfkB family
IS519_22810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_22810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_22810	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IS519_22825	COG0745	RESPONSE REGULATOR receiver
IS519_22845	COG3064	Membrane
IS519_22865	COG0625	glutathione transferase activity
IS519_22915	COG0784	Response regulator, receiver
IS519_22915	COG2198	Histidine kinase
IS519_22915	COG5002	protein histidine kinase activity
IS519_22920	COG1879	ABC-type sugar transport system periplasmic component
IS519_22925	COG1803	Methylglyoxal synthase
IS519_22935	COG0210	DNA helicase
IS519_22940	COG1289	transmembrane transporter activity
IS519_22960	COG0583	DNA-binding transcription factor activity
IS519_22965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IS519_22970	COG1328	CTP reductase activity
IS519_23000	COG1011	Hydrolase
IS519_23010	COG1454	alcohol dehydrogenase
IS519_23050	COG2249	NAD(P)H dehydrogenase (quinone) activity
IS519_23075	COG1063	alcohol dehydrogenase
IS519_23080	COG0156	8-amino-7-oxononanoate synthase activity
IS519_23085	COG2200	EAL domain
IS519_23100	COG0346	lactoylglutathione lyase activity
IS519_23120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IS519_23125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IS519_23140	COG0393	Putative heavy-metal-binding
IS519_23145	COG0739	heme binding
IS519_23170	COG1132	(ABC) transporter
IS519_23175	COG1132	(ABC) transporter
IS519_23180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IS519_23200	COG1760	l-serine dehydratase
IS519_23205	COG0840	transmembrane signaling receptor activity
IS519_23210	COG1522	sequence-specific DNA binding
IS519_23230	COG2814	Major facilitator Superfamily
IS519_23235	COG0583	DNA-binding transcription factor activity
IS519_23240	COG3437	response regulator, receiver
IS519_23240	COG3850	Histidine kinase
IS519_23240	COG2205	protein histidine kinase activity
IS519_23240	COG4999	Histidine kinase
IS519_23245	COG3437	response regulator, receiver
IS519_23250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IS519_23255	COG0573	inorganic phosphate transmembrane transporter activity
IS519_23265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IS519_23270	COG4604	ABC transporter, ATP-binding protein
IS519_23275	COG4605	iron ion homeostasis
IS519_23280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IS519_23285	COG4607	ABC-type enterochelin transport system periplasmic component
IS519_23325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IS519_23330	COG3530	Putative quorum-sensing-regulated virulence factor
IS519_23350	COG0109	protoheme IX farnesyltransferase activity
IS519_23375	COG1845	cytochrome c oxidase, subunit III
IS519_23385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IS519_23390	COG1565	acr, cog1565
IS519_23390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IS519_23395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IS519_23400	COG1280	lysine exporter protein (LysE YggA)
IS519_23405	COG0179	Fumarylacetoacetate (FAA) hydrolase
IS519_23415	COG0443	Heat shock 70 kDa protein
IS519_23445	COG2827	Endonuclease containing a URI domain
IS519_23450	COG3132	Protein of unknown function, DUF480
IS519_23460	COG2926	Belongs to the UPF0265 family
IS519_23485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IS519_23490	COG1151	hydroxylamine reductase activity
IS519_23505	COG1280	lysine exporter protein (LysE YggA)
IS519_23520	COG0531	amino acid
IS519_23535	COG4413	Urea transporter
IS519_23555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IS519_23560	COG0402	S-adenosylhomocysteine deaminase activity
IS519_23565	COG1278	Cold shock
IS519_23570	COG3706	GGDEF domain
IS519_23575	COG2963	transposase activity
IS519_23595	COG0513	Belongs to the DEAD box helicase family
IS519_23620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IS519_23635	COG3037	sugar-specific permease SgaT UlaA
IS519_23640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_23645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IS519_23650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IS519_23655	COG2205	protein histidine kinase activity
IS519_23660	COG0745	RESPONSE REGULATOR receiver
IS519_23665	COG5001	Diguanylate cyclase
IS519_23675	COG5001	Diguanylate cyclase
IS519_23680	COG2186	Transcriptional regulator
IS519_23685	COG1131	(ABC) transporter
IS519_23705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS519_23705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IS519_23715	COG0564	pseudouridine synthase activity
IS519_23725	COG2814	Major facilitator Superfamily
IS519_23770	COG4533	DNA binding
IS519_23775	COG0189	ligase activity
IS519_23780	COG4067	protein conserved in archaea
IS519_23780	COG0189	ligase activity
IS519_23800	COG1175	transmembrane transport
IS519_23805	COG0395	ABC-type sugar transport system, permease component
IS519_23810	COG3842	ATPase activity
IS519_23815	COG0584	glycerophosphoryl diester phosphodiesterase
IS519_23835	COG0673	inositol 2-dehydrogenase activity
IS519_23845	COG2999	glutathione oxidoreductase activity
IS519_23850	COG0840	transmembrane signaling receptor activity
IS519_23855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IS519_23880	COG0534	Mate efflux family protein
IS519_23885	COG0110	maltose O-acetyltransferase activity
IS519_23890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IS519_23900	COG3454	Phosphonate metabolism
IS519_23905	COG4778	phosphonate C-P lyase system protein PhnL
IS519_23910	COG4107	phosphonate C-P lyase system protein PhnK
IS519_23915	COG3627	carbon phosphorus lyase activity
IS519_23920	COG3626	phosphonate metabolism
IS519_23925	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IS519_23930	COG3624	Phosphonate C-P lyase system protein PhnG
IS519_23935	COG2188	Transcriptional regulator
IS519_23940	COG3639	organic phosphonate transmembrane transporter activity
IS519_23945	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IS519_23960	COG2964	Protein conserved in bacteria
IS519_23975	COG0446	pyridine nucleotide-disulphide oxidoreductase
IS519_24030	COG1901	pseudouridine methyltransferase
IS519_24060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IS519_24090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IS519_24100	COG0583	DNA-binding transcription factor activity
IS519_24105	COG2910	NAD(P)H-binding
IS519_24115	COG1028	Short-chain dehydrogenase reductase Sdr
IS519_24120	COG1733	regulation of RNA biosynthetic process
IS519_24125	COG0583	DNA-binding transcription factor activity
IS519_24130	COG4221	oxidoreductase activity
IS519_24140	COG3047	cAMP biosynthetic process
IS519_24145	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IS519_24150	COG1288	antiporter activity
IS519_24195	COG3639	organic phosphonate transmembrane transporter activity
IS519_24200	COG3639	organic phosphonate transmembrane transporter activity
IS519_24205	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IS519_24230	COG4948	Mandelate Racemase Muconate Lactonizing
IS519_24240	COG0583	DNA-binding transcription factor activity
IS519_24250	COG0656	L-ascorbic acid biosynthetic process
IS519_24255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS519_24260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IS519_24275	COG0191	fructose-bisphosphate aldolase activity
IS519_24295	COG2084	Dehydrogenase
IS519_24300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_24305	COG1349	DNA-binding transcription factor activity
IS519_24335	COG0583	DNA-binding transcription factor activity
IS519_24360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS519_24370	COG1757	Na H antiporter
IS519_24375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IS519_24395	COG2814	Major facilitator Superfamily
IS519_24400	COG1686	Belongs to the peptidase S11 family
IS519_24410	COG0583	DNA-binding transcription factor activity
IS519_24415	COG0814	amino acid
IS519_24420	COG2211	Major facilitator Superfamily
IS519_24425	COG1397	ADP-ribosylglycohydrolase
IS519_24430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IS519_24435	COG2223	nitrite transmembrane transporter activity
IS519_24440	COG2188	Transcriptional regulator
IS519_24445	COG0840	transmembrane signaling receptor activity
IS519_24460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_24465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_24475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IS519_24480	COG2207	Transcriptional regulator
IS519_24485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IS519_24485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_24485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_24500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IS519_24510	COG0765	amino acid transport
IS519_24515	COG3842	ATPase activity
IS519_24520	COG0546	phosphoglycolate phosphatase activity
IS519_24545	COG0583	DNA-binding transcription factor activity
IS519_24550	COG4166	transmembrane transport
IS519_24565	COG0302	gtp cyclohydrolase
IS519_24570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IS519_24575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IS519_24585	COG1882	Formate acetyltransferase
IS519_24595	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IS519_24600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IS519_24605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IS519_24620	COG1012	belongs to the aldehyde dehydrogenase family
IS519_24625	COG3284	Transcriptional regulator
IS519_24635	COG0625	glutathione transferase activity
IS519_24665	COG2871	sodium ion transport
IS519_24685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IS519_24690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IS519_24695	COG1418	mRNA catabolic process
IS519_24705	COG2706	6-phosphogluconolactonase activity
IS519_24710	COG2814	Major facilitator Superfamily
IS519_24735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IS519_24755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IS519_24755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IS519_24760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IS519_24770	COG1691	(AIR) carboxylase
IS519_24780	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IS519_24810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IS519_24820	COG0402	S-adenosylhomocysteine deaminase activity
IS519_24830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IS519_24835	COG0789	Transcriptional regulator
IS519_24850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IS519_24875	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IS519_24880	COG4266	Belongs to the allantoicase family
IS519_24900	COG2252	PERMEase
IS519_24925	COG0402	S-adenosylhomocysteine deaminase activity
IS519_24940	COG2084	Dehydrogenase
IS519_24945	COG3622	Belongs to the hyi family
IS519_24950	COG3960	tartronate-semialdehyde synthase activity
IS519_24955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IS519_24965	COG1846	Transcriptional regulator
IS519_25005	COG1067	ATP-dependent peptidase activity
IS519_25015	COG4172	Belongs to the ABC transporter superfamily
IS519_25020	COG1609	Transcriptional regulator
IS519_25030	COG2017	converts alpha-aldose to the beta-anomer
IS519_25035	COG3459	Glycosyltransferase 36 associated
IS519_25040	COG3842	ATPase activity
IS519_25045	COG2723	6-phospho-beta-galactosidase activity
IS519_25050	COG0395	ABC-type sugar transport system, permease component
IS519_25085	COG1505	serine-type exopeptidase activity
IS519_25090	COG0583	DNA-binding transcription factor activity
IS519_25095	COG1620	l-lactate permease
IS519_25100	COG1304	FMN binding
IS519_25120	COG0747	negative chemotaxis
IS519_25125	COG4608	Belongs to the ABC transporter superfamily
IS519_25135	COG0534	Mate efflux family protein
IS519_25140	COG2207	Transcriptional regulator
IS519_25140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IS519_25145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IS519_25160	COG1054	Belongs to the UPF0176 family
IS519_25175	COG0745	RESPONSE REGULATOR receiver
IS519_25195	COG2271	Major facilitator Superfamily
IS519_25200	COG3851	Histidine kinase
IS519_25205	COG2197	response regulator
IS519_25220	COG0583	DNA-binding transcription factor activity
IS519_25225	COG0534	Mate efflux family protein
IS519_25230	COG1024	Enoyl-CoA hydratase
IS519_25235	COG0300	oxidoreductase activity
IS519_25255	COG1720	tRNA m6t6A37 methyltransferase activity
IS519_25260	COG0800	Aldolase
IS519_25265	COG2723	6-phospho-beta-galactosidase activity
IS519_25270	COG1263	PTS System
IS519_25270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IS519_25275	COG3265	gluconokinase activity
IS519_25280	COG0129	dihydroxy-acid dehydratase activity
IS519_25285	COG1609	Transcriptional regulator
IS519_25295	COG3547	Transposase (IS116 IS110 IS902 family)