locus-tag	class	description
ISX50_00015	COG2885	chlorophyll binding
ISX50_00025	COG3706	GGDEF domain
ISX50_00030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISX50_00035	COG0602	queuosine metabolic process
ISX50_00040	COG0561	phosphatase activity
ISX50_00075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISX50_00080	COG0372	Belongs to the citrate synthase family
ISX50_00085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ISX50_00095	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISX50_00125	COG4628	conserved protein (DUF2132)
ISX50_00135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ISX50_00140	COG0363	glucosamine-6-phosphate deaminase activity
ISX50_00145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISX50_00150	COG4565	transcriptional regulatory protein
ISX50_00155	COG3290	protein histidine kinase activity
ISX50_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_00185	COG1115	amino acid carrier protein
ISX50_00205	COG1115	amino acid carrier protein
ISX50_00210	COG1280	lysine exporter protein (LysE YggA)
ISX50_00215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISX50_00230	COG0730	response to heat
ISX50_00245	COG0454	-acetyltransferase
ISX50_00255	COG4977	sequence-specific DNA binding
ISX50_00285	COG0471	metal ion transport
ISX50_00340	COG3033	Beta-eliminating lyase
ISX50_00365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_00385	COG2176	DNA-directed DNA polymerase activity
ISX50_00390	COG0517	IMP dehydrogenase activity
ISX50_00395	COG2186	Transcriptional regulator
ISX50_00400	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_00405	COG2186	Transcriptional regulator
ISX50_00440	COG0840	transmembrane signaling receptor activity
ISX50_00455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_00465	COG3181	Tripartite tricarboxylate transporter family receptor
ISX50_00480	COG2186	Transcriptional regulator
ISX50_00490	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ISX50_00495	COG3639	organic phosphonate transmembrane transporter activity
ISX50_00520	COG1917	Cupin 2, conserved barrel domain protein
ISX50_00525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX50_00530	COG0800	Aldolase
ISX50_00535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_00540	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ISX50_00550	COG0010	Belongs to the arginase family
ISX50_00555	COG1166	arginine decarboxylase activity
ISX50_00565	COG1309	transcriptional regulator
ISX50_00570	COG0488	(ABC) transporter
ISX50_00585	COG3097	Belongs to the UPF0267 family
ISX50_00590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISX50_00595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ISX50_00615	COG4326	sporulation control protein
ISX50_00625	COG1228	amidohydrolase
ISX50_00630	COG0010	Belongs to the arginase family
ISX50_00635	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISX50_00640	COG2986	histidine ammonia-lyase
ISX50_00655	COG0247	lactate metabolic process
ISX50_00655	COG0277	FAD linked oxidase domain protein
ISX50_00690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ISX50_00695	COG3385	transposase activity
ISX50_00705	COG1643	Atp-dependent helicase
ISX50_00710	COG0281	malic enzyme
ISX50_00715	COG2949	membrane
ISX50_00720	COG0471	metal ion transport
ISX50_00735	COG2199	diguanylate cyclase activity
ISX50_00750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISX50_00765	COG0492	ferredoxin-NADP+ reductase activity
ISX50_00770	COG4988	ABC transporter
ISX50_00775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISX50_00780	COG0840	transmembrane signaling receptor activity
ISX50_00785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISX50_00790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISX50_00815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ISX50_00830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX50_00835	COG3108	Peptidase M15
ISX50_00840	COG2989	Protein conserved in bacteria
ISX50_00865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISX50_00875	COG4235	cytochrome complex assembly
ISX50_00875	COG3088	subunit of a heme lyase
ISX50_00885	COG1138	Cytochrome C-type biogenesis protein
ISX50_00890	COG3301	Polysulphide reductase, NrfD
ISX50_00895	COG0437	4 iron, 4 sulfur cluster binding
ISX50_00905	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ISX50_00910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX50_00925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISX50_00930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX50_00935	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX50_00950	COG3381	protein complex oligomerization
ISX50_00955	COG0243	molybdopterin cofactor binding
ISX50_00960	COG0437	4 iron, 4 sulfur cluster binding
ISX50_00965	COG3302	dmso reductase anchor subunit
ISX50_00970	COG1058	Belongs to the CinA family
ISX50_00970	COG1546	Belongs to the CinA family
ISX50_00985	COG0019	diaminopimelate decarboxylase activity
ISX50_01025	COG0322	excinuclease ABC activity
ISX50_01030	COG2197	response regulator
ISX50_01035	COG0417	DNA replication proofreading
ISX50_01045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISX50_01060	COG1187	pseudouridine synthase activity
ISX50_01065	COG0009	L-threonylcarbamoyladenylate synthase
ISX50_01070	COG0613	PHP domain protein
ISX50_01080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISX50_01085	COG0512	Glutamine amidotransferase of anthranilate synthase
ISX50_01090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISX50_01095	COG0134	indole-3-glycerol-phosphate synthase activity
ISX50_01095	COG0135	phosphoribosylanthranilate isomerase activity
ISX50_01100	COG0133	tryptophan synthase activity
ISX50_01105	COG0159	tryptophan synthase activity
ISX50_01110	COG1301	dicarboxylic acid transport
ISX50_01120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ISX50_01140	COG0583	DNA-binding transcription factor activity
ISX50_01150	COG2917	probably involved in intracellular septation
ISX50_01155	COG1607	acyl-coa hydrolase
ISX50_01160	COG2350	Protein conserved in bacteria
ISX50_01170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISX50_01175	COG0583	DNA-binding transcription factor activity
ISX50_01190	COG1032	radical SAM domain protein
ISX50_01195	COG1396	sequence-specific DNA binding
ISX50_01200	COG3135	benzoate transporter
ISX50_01215	COG0463	Glycosyl transferase, family 2
ISX50_01220	COG0745	RESPONSE REGULATOR receiver
ISX50_01240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX50_01245	COG0583	DNA-binding transcription factor activity
ISX50_01290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ISX50_01310	COG1349	DNA-binding transcription factor activity
ISX50_01315	COG0786	glutamate:sodium symporter activity
ISX50_01330	COG0784	Response regulator, receiver
ISX50_01330	COG5002	protein histidine kinase activity
ISX50_01345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISX50_01350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISX50_01355	COG2885	chlorophyll binding
ISX50_01360	COG0823	Involved in the tonB-independent uptake of proteins
ISX50_01375	COG0811	peptide transport
ISX50_01380	COG0824	Thioesterase
ISX50_01390	COG4890	Cyd operon protein YbgT
ISX50_01395	COG1294	oxidase, subunit
ISX50_01400	COG1271	oxidase subunit
ISX50_01405	COG2255	four-way junction helicase activity
ISX50_01410	COG0632	four-way junction helicase activity
ISX50_01420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ISX50_01425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISX50_01430	COG1801	Protein of unknown function DUF72
ISX50_01435	COG4106	trans-aconitate 2-methyltransferase activity
ISX50_01440	COG0500	methyltransferase
ISX50_01445	COG0189	ligase activity
ISX50_01445	COG4067	protein conserved in archaea
ISX50_01460	COG3383	formate dehydrogenase (NAD+) activity
ISX50_01465	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ISX50_01470	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ISX50_01475	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ISX50_01480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISX50_01485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISX50_01490	COG0745	RESPONSE REGULATOR receiver
ISX50_01495	COG3381	protein complex oligomerization
ISX50_01500	COG1609	Transcriptional regulator
ISX50_01505	COG3070	regulator of competence-specific genes
ISX50_01525	COG0297	glycogen (starch) synthase activity
ISX50_01530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ISX50_01535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISX50_01545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ISX50_01555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ISX50_01560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISX50_01565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISX50_01570	COG0542	response to heat
ISX50_01575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ISX50_01580	COG1278	Cold shock
ISX50_01590	COG1187	pseudouridine synthase activity
ISX50_01595	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ISX50_01600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISX50_01605	COG1199	ATP-dependent helicase activity
ISX50_01625	COG2850	peptidyl-arginine hydroxylation
ISX50_01630	COG0840	transmembrane signaling receptor activity
ISX50_01635	COG2814	Major facilitator Superfamily
ISX50_01640	COG1770	oligopeptidase
ISX50_01645	COG0708	Exodeoxyribonuclease III
ISX50_01655	COG4160	amino acid transport
ISX50_01685	COG1882	Formate acetyltransferase
ISX50_01695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISX50_01700	COG3013	Belongs to the UPF0304 family
ISX50_01705	COG2766	serine protein kinase
ISX50_01710	COG2718	Belongs to the UPF0229 family
ISX50_01715	COG2719	SpoVR family
ISX50_01720	COG0616	signal peptide processing
ISX50_01725	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_01730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISX50_01745	COG0835	chemotaxis
ISX50_01745	COG0784	Response regulator, receiver
ISX50_01750	COG1940	carbohydrate kinase activity
ISX50_01755	COG0469	pyruvate kinase activity
ISX50_01760	COG4667	esterase of the alpha-beta hydrolase superfamily
ISX50_01785	COG0084	hydrolase, TatD family'
ISX50_01800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISX50_01805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISX50_01830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX50_01835	COG0416	fatty acid biosynthetic process
ISX50_01840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISX50_01845	COG1399	metal-binding, possibly nucleic acid-binding protein
ISX50_01855	COG0564	pseudouridine synthase activity
ISX50_01860	COG1530	ribonuclease E activity
ISX50_01865	COG0659	secondary active sulfate transmembrane transporter activity
ISX50_01870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISX50_01875	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISX50_01880	COG2982	Protein involved in outer membrane biogenesis
ISX50_01885	COG0572	uridine kinase
ISX50_01890	COG0489	protein tyrosine kinase activity
ISX50_01895	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX50_01895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX50_01905	COG2186	Transcriptional regulator
ISX50_01910	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ISX50_01915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISX50_01920	COG0653	protein targeting
ISX50_01925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISX50_01930	COG3706	GGDEF domain
ISX50_01945	COG3092	negative regulation of chromosome organization
ISX50_01950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ISX50_01955	COG0857	belongs to the CobB CobQ family
ISX50_01955	COG0280	phosphate acetyltransferase
ISX50_01960	COG0435	Glutathione S-transferase
ISX50_01970	COG0444	Belongs to the ABC transporter superfamily
ISX50_01975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX50_01980	COG0601	transmembrane transport
ISX50_01990	COG0314	molybdopterin synthase activity
ISX50_01995	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISX50_02000	COG0315	cyclic pyranopterin monophosphate synthase activity
ISX50_02005	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISX50_02010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISX50_02015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISX50_02020	COG2198	Histidine kinase
ISX50_02025	COG2204	response regulator
ISX50_02030	COG0556	nucleotide-excision repair
ISX50_02040	COG4657	Part of a membrane complex involved in electron transport
ISX50_02045	COG2878	Part of a membrane complex involved in electron transport
ISX50_02050	COG4656	Part of a membrane complex involved in electron transport
ISX50_02055	COG4658	electron transport chain
ISX50_02060	COG4659	FMN binding
ISX50_02065	COG4660	Part of a membrane complex involved in electron transport
ISX50_02070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISX50_02075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ISX50_02080	COG0346	lactoylglutathione lyase activity
ISX50_02095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISX50_02100	COG2056	Na+-H+ antiporter family
ISX50_02110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISX50_02130	COG2267	carboxylic ester hydrolase activity
ISX50_02135	COG3706	GGDEF domain
ISX50_02140	COG2198	Histidine kinase
ISX50_02140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX50_02140	COG2205	protein histidine kinase activity
ISX50_02140	COG0784	Response regulator, receiver
ISX50_02145	COG2199	diguanylate cyclase activity
ISX50_02145	COG2202	Pas domain
ISX50_02145	COG2200	EAL domain
ISX50_02150	COG2197	response regulator
ISX50_02170	COG0840	transmembrane signaling receptor activity
ISX50_02185	COG1012	belongs to the aldehyde dehydrogenase family
ISX50_02185	COG1454	alcohol dehydrogenase
ISX50_02190	COG2095	MarC family integral membrane protein
ISX50_02195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISX50_02200	COG2165	general secretion pathway protein
ISX50_02205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISX50_02210	COG1757	Na H antiporter
ISX50_02225	COG3081	Nucleoid-associated protein
ISX50_02230	COG3082	Protein of unknown function (DUF1414)
ISX50_02235	COG3083	sulfuric ester hydrolase activity
ISX50_02250	COG0840	transmembrane signaling receptor activity
ISX50_02255	COG0123	including yeast histone deacetylase and acetoin utilization protein
ISX50_02270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISX50_02275	COG0778	Nitroreductase
ISX50_02280	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISX50_02280	COG1902	pentaerythritol trinitrate reductase activity
ISX50_02285	COG0616	signal peptide processing
ISX50_02290	COG0252	asparaginase activity
ISX50_02295	COG3139	Protein of unknown function (DUF1315)
ISX50_02305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX50_02310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISX50_02325	COG2226	methyltransferase
ISX50_02345	COG2983	Belongs to the UPF0260 family
ISX50_02360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ISX50_02365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ISX50_02370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISX50_02375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISX50_02380	COG2832	Protein of unknown function (DUF454)
ISX50_02390	COG0745	RESPONSE REGULATOR receiver
ISX50_02395	COG0583	DNA-binding transcription factor activity
ISX50_02400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISX50_02405	COG1286	toxin biosynthetic process
ISX50_02410	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISX50_02415	COG0285	dihydrofolate synthase activity
ISX50_02420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISX50_02425	COG0101	tRNA pseudouridine synthase activity
ISX50_02435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISX50_02440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISX50_02445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISX50_02455	COG0431	NADPH-dependent FMN reductase
ISX50_02465	COG3101	peptidyl-lysine hydroxylation
ISX50_02470	COG2860	membrane
ISX50_02475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ISX50_02490	COG2815	serine threonine protein kinase
ISX50_02490	COG0515	serine threonine protein kinase
ISX50_02500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISX50_02510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISX50_02515	COG0583	DNA-binding transcription factor activity
ISX50_02520	COG2951	lytic endotransglycosylase activity
ISX50_02525	COG3100	YcgL domain-containing protein
ISX50_02530	COG0850	regulation of cytokinetic process
ISX50_02535	COG2894	cell division
ISX50_02540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISX50_02545	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISX50_02550	COG0318	PFAM AMP-dependent synthetase and ligase
ISX50_02555	COG0596	Alpha beta hydrolase
ISX50_02570	COG1214	PFAM Peptidase M22, glycoprotease
ISX50_02575	COG1199	ATP-dependent helicase activity
ISX50_02585	COG0788	formyltetrahydrofolate deformylase activity
ISX50_02590	COG3102	Protein conserved in bacteria
ISX50_02595	COG0018	arginyl-trna synthetase
ISX50_02615	COG1918	ferrous iron import across plasma membrane
ISX50_02625	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISX50_02630	COG1121	(ABC) transporter
ISX50_02635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISX50_02645	COG0045	succinate-CoA ligase (ADP-forming) activity
ISX50_02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX50_02655	COG0567	Dehydrogenase, E1 component
ISX50_02660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISX50_02665	COG1053	succinate dehydrogenase
ISX50_02670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISX50_02685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISX50_02695	COG0033	Phosphoglucomutase
ISX50_02700	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISX50_02705	COG0596	Alpha beta hydrolase
ISX50_02730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISX50_02735	COG1263	PTS System
ISX50_02735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX50_02735	COG2190	(PTS) system
ISX50_02740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISX50_02745	COG1846	Transcriptional regulator
ISX50_02745	COG1940	carbohydrate kinase activity
ISX50_02750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISX50_02750	COG4651	solute:proton antiporter activity
ISX50_02755	COG0367	asparagine synthase
ISX50_02765	COG3104	oligopeptide transport
ISX50_02770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISX50_02775	COG0563	adenylate kinase activity
ISX50_02780	COG0326	Molecular chaperone. Has ATPase activity
ISX50_02785	COG3710	Transcriptional regulator
ISX50_02800	COG0622	Phosphoesterase
ISX50_02825	COG1090	epimerase
ISX50_02830	COG0300	oxidoreductase activity
ISX50_02835	COG3118	belongs to the thioredoxin family
ISX50_02840	COG0330	HflC and HflK could
ISX50_02850	COG0789	Transcriptional regulator
ISX50_02870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISX50_02875	COG3115	cell septum assembly
ISX50_02880	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISX50_02890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_02900	COG2190	(PTS) system
ISX50_02905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX50_02910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX50_02915	COG2837	iron assimilation
ISX50_02940	COG1393	Belongs to the ArsC family
ISX50_02945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISX50_02960	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISX50_02965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISX50_02970	COG2716	regulation of RNA biosynthetic process
ISX50_02975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISX50_02990	COG4783	chaperone-mediated protein folding
ISX50_02995	COG1393	Belongs to the ArsC family
ISX50_03015	COG2233	PERMEase
ISX50_03025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ISX50_03030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISX50_03035	COG0121	glutamine amidotransferase
ISX50_03040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ISX50_03045	COG1960	acyl-CoA dehydrogenase activity
ISX50_03055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISX50_03060	COG0328	RNA-DNA hybrid ribonuclease activity
ISX50_03065	COG2226	methyltransferase
ISX50_03070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX50_03075	COG1388	LysM domain
ISX50_03075	COG0741	lytic transglycosylase activity
ISX50_03085	COG3021	interspecies interaction between organisms
ISX50_03090	COG0347	Belongs to the P(II) protein family
ISX50_03100	COG0037	tRNA processing
ISX50_03105	COG0825	malonyl-CoA metabolic process
ISX50_03110	COG0587	DNA-directed DNA polymerase activity
ISX50_03115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISX50_03125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISX50_03130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISX50_03135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISX50_03140	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ISX50_03150	COG0750	zinc metalloprotease
ISX50_03160	COG0575	Belongs to the CDS family
ISX50_03165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISX50_03170	COG0233	cytoplasmic translational termination
ISX50_03175	COG0528	UMP kinase activity
ISX50_03180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISX50_03185	COG0052	Belongs to the universal ribosomal protein uS2 family
ISX50_03190	COG0024	Methionine aminopeptidase
ISX50_03195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ISX50_03205	COG0564	pseudouridine synthase activity
ISX50_03210	COG3098	single-species biofilm formation
ISX50_03235	COG1671	Belongs to the UPF0178 family
ISX50_03255	COG0254	rRNA binding
ISX50_03260	COG1720	tRNA m6t6A37 methyltransferase activity
ISX50_03265	COG0442	prolyl-tRNA aminoacylation
ISX50_03300	COG0366	Alpha amylase catalytic
ISX50_03305	COG1263	PTS System
ISX50_03305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX50_03310	COG1609	Transcriptional regulator
ISX50_03320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISX50_03325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX50_03330	COG2011	ABC-type metal ion transport system permease component
ISX50_03335	COG1464	Belongs to the NlpA lipoprotein family
ISX50_03340	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ISX50_03350	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ISX50_03350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ISX50_03365	COG1611	Belongs to the LOG family
ISX50_03370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISX50_03375	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ISX50_03390	COG0583	DNA-binding transcription factor activity
ISX50_03395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX50_03395	COG0301	tRNA thio-modification
ISX50_03405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISX50_03410	COG1722	exodeoxyribonuclease VII activity
ISX50_03415	COG0142	geranyltranstransferase activity
ISX50_03420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISX50_03430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISX50_03435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISX50_03440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISX50_03460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISX50_03460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISX50_03465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISX50_03470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISX50_03485	COG1073	alpha beta
ISX50_03490	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ISX50_03495	COG2252	PERMEase
ISX50_03500	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISX50_03520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ISX50_03535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX50_03540	COG1609	Transcriptional regulator
ISX50_03545	COG2017	converts alpha-aldose to the beta-anomer
ISX50_03555	COG1085	galactose-1-phosphate uridylyltransferase
ISX50_03560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISX50_03565	COG1609	Transcriptional regulator
ISX50_03570	COG3250	beta-galactosidase activity
ISX50_03575	COG2731	YhcH YjgK YiaL family protein
ISX50_03580	COG0531	amino acid
ISX50_03590	COG3250	beta-galactosidase activity
ISX50_03600	COG0395	ABC-type sugar transport system, permease component
ISX50_03605	COG1175	transmembrane transport
ISX50_03615	COG0534	Mate efflux family protein
ISX50_03620	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_03630	COG1609	Transcriptional regulator
ISX50_03635	COG0583	DNA-binding transcription factor activity
ISX50_03640	COG2059	Chromate
ISX50_03645	COG2226	methyltransferase
ISX50_03705	COG4964	Belongs to the GSP D family
ISX50_03735	COG1022	Amp-dependent synthetase and ligase
ISX50_03755	COG4628	conserved protein (DUF2132)
ISX50_03785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISX50_03790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISX50_03800	COG0560	Phosphoserine phosphatase
ISX50_03810	COG0813	purine-nucleoside phosphorylase activity
ISX50_03820	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ISX50_03825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISX50_03830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISX50_03835	COG0084	hydrolase, TatD family'
ISX50_03845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISX50_03860	COG3153	acetyltransferase
ISX50_03865	COG3154	lipid carrier protein
ISX50_03875	COG0826	peptidase U32
ISX50_03880	COG0826	peptidase U32
ISX50_03885	COG0534	Mate efflux family protein
ISX50_03900	COG1185	polyribonucleotide nucleotidyltransferase activity
ISX50_03905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ISX50_03910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ISX50_03915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ISX50_03920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ISX50_03925	COG0195	Participates in both transcription termination and antitermination
ISX50_03930	COG0779	Required for maturation of 30S ribosomal subunits
ISX50_03945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISX50_03950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX50_03955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISX50_03960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISX50_03965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISX50_03970	COG1534	Rna-binding protein
ISX50_03975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISX50_03980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISX50_03985	COG2027	D-alanyl-D-alanine carboxypeptidase
ISX50_03990	COG2239	Acts as a magnesium transporter
ISX50_03995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISX50_04000	COG0739	heme binding
ISX50_04015	COG0316	Belongs to the HesB IscA family
ISX50_04020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISX50_04025	COG0628	permease
ISX50_04030	COG2813	Specifically methylates the guanine in position
ISX50_04040	COG0747	negative chemotaxis
ISX50_04050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX50_04055	COG0444	Belongs to the ABC transporter superfamily
ISX50_04060	COG4608	Belongs to the ABC transporter superfamily
ISX50_04070	COG2971	BadF BadG BcrA BcrD
ISX50_04085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX50_04090	COG3842	ATPase activity
ISX50_04100	COG1840	ABC-type Fe3 transport system, periplasmic component
ISX50_04105	COG0004	ammonium transporteR
ISX50_04120	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISX50_04125	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISX50_04130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX50_04135	COG1643	Atp-dependent helicase
ISX50_04140	COG1489	DNA binding
ISX50_04160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISX50_04165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISX50_04170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ISX50_04175	COG0842	Transport permease protein
ISX50_04180	COG1131	(ABC) transporter
ISX50_04185	COG0659	secondary active sulfate transmembrane transporter activity
ISX50_04190	COG0288	reversible hydration of carbon dioxide
ISX50_04205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISX50_04210	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX50_04215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISX50_04230	COG0157	Belongs to the NadC ModD family
ISX50_04240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISX50_04245	COG1459	type II secretion system
ISX50_04255	COG0237	dephospho-CoA kinase activity
ISX50_04260	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ISX50_04270	COG0335	large ribosomal subunit rRNA binding
ISX50_04275	COG0336	Belongs to the RNA methyltransferase TrmD family
ISX50_04280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISX50_04285	COG0228	four-way junction DNA binding
ISX50_04290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISX50_04295	COG4137	Cytochrome C assembly protein
ISX50_04300	COG4536	flavin adenine dinucleotide binding
ISX50_04305	COG1854	S-ribosylhomocysteine lyase activity
ISX50_04315	COG2918	glutathione biosynthetic process
ISX50_04320	COG0612	Peptidase, M16
ISX50_04325	COG1238	metal cluster binding
ISX50_04335	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ISX50_04340	COG0511	ligase activity, forming carbon-carbon bonds
ISX50_04340	COG5016	pyruvate
ISX50_04345	COG3630	sodium ion export across plasma membrane
ISX50_04405	COG0527	aspartate kinase activity
ISX50_04415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISX50_04420	COG1546	Belongs to the CinA family
ISX50_04425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISX50_04430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISX50_04440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISX50_04445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISX50_04450	COG0585	pseudouridine synthase activity
ISX50_04460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISX50_04465	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ISX50_04470	COG0148	phosphopyruvate hydratase activity
ISX50_04475	COG0504	CTP synthase activity
ISX50_04480	COG3956	TIGRFAM MazG family protein
ISX50_04485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISX50_04490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISX50_04495	COG2205	protein histidine kinase activity
ISX50_04495	COG3437	response regulator, receiver
ISX50_04495	COG3850	Histidine kinase
ISX50_04495	COG4999	Histidine kinase
ISX50_04500	COG0736	holo-[acyl-carrier-protein] synthase activity
ISX50_04505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISX50_04510	COG1381	Involved in DNA repair and RecF pathway recombination
ISX50_04515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISX50_04520	COG0571	ribonuclease III activity
ISX50_04530	COG0481	GTPase activity
ISX50_04550	COG1595	DNA-templated transcription, initiation
ISX50_04555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISX50_04565	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISX50_04570	COG0354	folic acid binding
ISX50_04585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISX50_04590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISX50_04595	COG3079	Belongs to the UPF0149 family
ISX50_04600	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ISX50_04610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISX50_04615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISX50_04620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISX50_04625	COG3385	transposase activity
ISX50_04645	COG0668	transmembrane transport
ISX50_04650	COG0191	fructose-bisphosphate aldolase activity
ISX50_04665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISX50_04670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISX50_04680	COG3091	SprT-like family
ISX50_04685	COG2356	endonuclease I
ISX50_04695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISX50_04700	COG0189	ligase activity
ISX50_04705	COG1678	Uncharacterized ACR, COG1678
ISX50_04710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISX50_04730	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISX50_04735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISX50_04740	COG0762	integral membrane protein
ISX50_04755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISX50_04760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISX50_04765	COG2066	Belongs to the glutaminase family
ISX50_04780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ISX50_04785	COG0741	lytic transglycosylase activity
ISX50_04825	COG0840	transmembrane signaling receptor activity
ISX50_04945	COG0795	lipopolysaccharide-transporting ATPase activity
ISX50_04950	COG0795	lipopolysaccharide-transporting ATPase activity
ISX50_04955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISX50_04960	COG2927	DNA polymerase III (CHI subunit)
ISX50_04965	COG0525	valine-tRNA ligase activity
ISX50_04975	COG0456	acetyltransferase
ISX50_05005	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ISX50_05010	COG0251	oxidation-reduction process
ISX50_05015	COG0204	Acyl-transferase
ISX50_05020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISX50_05025	COG5007	Belongs to the BolA IbaG family
ISX50_05035	COG2854	intermembrane phospholipid transfer
ISX50_05040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISX50_05045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISX50_05050	COG1127	ABC transporter
ISX50_05060	COG0517	IMP dehydrogenase activity
ISX50_05060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISX50_05065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISX50_05075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISX50_05080	COG1137	ATPase activity
ISX50_05090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISX50_05095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_05100	COG1660	Displays ATPase and GTPase activities
ISX50_05105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_05110	COG2239	Acts as a magnesium transporter
ISX50_05115	COG0312	modulator of DNA gyrase
ISX50_05120	COG3028	Belongs to the UPF0307 family
ISX50_05125	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISX50_05130	COG1178	ABC-type Fe3 transport system permease component
ISX50_05135	COG4143	(ABC) transporter
ISX50_05140	COG0163	prenyltransferase activity
ISX50_05145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISX50_05150	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISX50_05155	COG2105	PFAM AIG2 family protein
ISX50_05160	COG2911	Protein conserved in bacteria
ISX50_05165	COG0729	surface antigen
ISX50_05170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX50_05180	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISX50_05215	COG0529	Catalyzes the synthesis of activated sulfate
ISX50_05220	COG3273	potassium ion transport
ISX50_05220	COG0471	metal ion transport
ISX50_05225	COG2895	sulfate adenylyltransferase (ATP) activity
ISX50_05230	COG0175	sulfate reduction
ISX50_05280	COG2153	protein acetylation
ISX50_05290	COG3266	domain, Protein
ISX50_05290	COG3061	Opacity-associated protein A
ISX50_05295	COG0545	Peptidyl-prolyl cis-trans isomerase
ISX50_05310	COG0203	ribosomal protein L17
ISX50_05315	COG0202	RNA polymerase activity
ISX50_05320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISX50_05325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ISX50_05330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ISX50_05335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISX50_05340	COG0201	protein transport
ISX50_05345	COG0200	Binds to the 23S rRNA
ISX50_05350	COG1841	ribosomal large subunit assembly
ISX50_05355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ISX50_05360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ISX50_05365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ISX50_05370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ISX50_05375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISX50_05380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISX50_05385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISX50_05390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISX50_05395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISX50_05405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISX50_05410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISX50_05420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISX50_05425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISX50_05430	COG0089	rRNA binding
ISX50_05435	COG0088	Forms part of the polypeptide exit tunnel
ISX50_05440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ISX50_05455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISX50_05475	COG2923	Belongs to the DsrF TusC family
ISX50_05480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISX50_05485	COG2964	Protein conserved in bacteria
ISX50_05490	COG0545	Peptidyl-prolyl cis-trans isomerase
ISX50_05500	COG2900	Belongs to the SlyX family
ISX50_05505	COG1446	asparaginase
ISX50_05510	COG1047	Peptidyl-prolyl cis-trans
ISX50_05525	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISX50_05530	COG0488	(ABC) transporter
ISX50_05540	COG0429	hydrolase of the alpha beta-hydrolase fold
ISX50_05545	COG3089	Belongs to the UPF0270 family
ISX50_05550	COG3954	Phosphoribulokinase
ISX50_05555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISX50_05565	COG1012	belongs to the aldehyde dehydrogenase family
ISX50_05575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISX50_05580	COG0512	Glutamine amidotransferase of anthranilate synthase
ISX50_05585	COG2356	endonuclease I
ISX50_05605	COG0180	Tryptophanyl-tRNA synthetase
ISX50_05610	COG0546	phosphoglycolate phosphatase activity
ISX50_05615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISX50_05620	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ISX50_05630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ISX50_05665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISX50_05675	COG0678	peroxiredoxin activity
ISX50_05675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISX50_05680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISX50_05685	COG0251	oxidation-reduction process
ISX50_05695	COG0165	Argininosuccinate lyase
ISX50_05695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISX50_05710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISX50_05715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISX50_05720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ISX50_05730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISX50_05735	COG0460	homoserine dehydrogenase
ISX50_05735	COG0527	aspartate kinase activity
ISX50_05740	COG0626	cystathionine gamma-synthase activity
ISX50_05745	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ISX50_05750	COG0281	malic enzyme
ISX50_05755	COG0254	rRNA binding
ISX50_05760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISX50_05765	COG1609	Transcriptional regulator
ISX50_05775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ISX50_05780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISX50_05785	COG1575	Belongs to the MenA family. Type 1 subfamily
ISX50_05790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISX50_05795	COG3074	FtsZ-dependent cytokinesis
ISX50_05800	COG1494	fructose-1,6-bisphosphatase
ISX50_05815	COG3152	Membrane
ISX50_05825	COG0149	triose-phosphate isomerase activity
ISX50_05835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISX50_05845	COG0745	RESPONSE REGULATOR receiver
ISX50_05850	COG2205	protein histidine kinase activity
ISX50_05860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISX50_05870	COG1027	Aspartate ammonia-lyase
ISX50_05875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISX50_05880	COG1288	antiporter activity
ISX50_05890	COG0549	Belongs to the carbamate kinase family
ISX50_05895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISX50_05900	COG0540	Belongs to the ATCase OTCase family
ISX50_05905	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ISX50_05910	COG1438	arginine binding
ISX50_05915	COG4232	protein-disulfide reductase activity
ISX50_05925	COG3263	regulation of cellular component size
ISX50_05935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_05950	COG0784	Response regulator, receiver
ISX50_05950	COG2198	Histidine kinase
ISX50_05950	COG2205	protein histidine kinase activity
ISX50_05955	COG2814	Major facilitator Superfamily
ISX50_05970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISX50_05975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISX50_05980	COG0511	ligase activity, forming carbon-carbon bonds
ISX50_05985	COG0439	Biotin carboxylase
ISX50_05990	COG2264	protein methyltransferase activity
ISX50_05995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISX50_06000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISX50_06005	COG0789	Transcriptional regulator
ISX50_06010	COG0138	bifunctional purine biosynthesis protein purh
ISX50_06015	COG0151	Belongs to the GarS family
ISX50_06030	COG1253	flavin adenine dinucleotide binding
ISX50_06035	COG3068	Protein conserved in bacteria
ISX50_06045	COG1573	uracil-dna glycosylase
ISX50_06055	COG2816	NAD+ diphosphatase activity
ISX50_06060	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ISX50_06075	COG0222	ribosome binding
ISX50_06080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ISX50_06085	COG0081	regulation of translation
ISX50_06095	COG0250	Participates in transcription elongation, termination and antitermination
ISX50_06100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISX50_06130	COG1072	(Pantothenic acid kinase))
ISX50_06140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISX50_06150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISX50_06255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISX50_06265	COG4206	TonB-dependent receptor
ISX50_06270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISX50_06330	COG2003	Belongs to the UPF0758 family
ISX50_06385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISX50_06390	COG0534	Mate efflux family protein
ISX50_06395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ISX50_06400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISX50_06405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISX50_06410	COG2937	Belongs to the GPAT DAPAT family
ISX50_06415	COG3385	transposase activity
ISX50_06420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISX50_06425	COG3161	chorismate lyase activity
ISX50_06430	COG1580	Controls the rotational direction of flagella during chemotaxis
ISX50_06435	COG0705	Rhomboid family
ISX50_06440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX50_06450	COG2177	Part of the ABC transporter FtsEX involved in
ISX50_06455	COG2884	Cell division ATP-binding protein ftsE
ISX50_06460	COG0552	protein localization to endoplasmic reticulum
ISX50_06465	COG0742	ribosomal rna small subunit methyltransferase
ISX50_06475	COG2095	MarC family integral membrane protein
ISX50_06515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISX50_06520	COG0640	Transcriptional regulator
ISX50_06525	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ISX50_06530	COG1280	lysine exporter protein (LysE YggA)
ISX50_06535	COG2267	carboxylic ester hydrolase activity
ISX50_06540	COG0561	phosphatase activity
ISX50_06555	COG3148	PFAM DTW domain containing protein
ISX50_06560	COG3287	FIST C domain
ISX50_06560	COG2200	EAL domain
ISX50_06560	COG2199	diguanylate cyclase activity
ISX50_06565	COG2199	diguanylate cyclase activity
ISX50_06565	COG2200	EAL domain
ISX50_06565	COG3287	FIST C domain
ISX50_06570	COG1011	Hydrolase
ISX50_06575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISX50_06585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISX50_06590	COG0019	diaminopimelate decarboxylase activity
ISX50_06600	COG1965	Belongs to the frataxin family
ISX50_06605	COG3072	Adenylate cyclase
ISX50_06610	COG0181	hydroxymethylbilane synthase activity
ISX50_06615	COG1587	Uroporphyrinogen-III synthase
ISX50_06620	COG2959	enzyme of heme biosynthesis
ISX50_06625	COG3071	HemY protein
ISX50_06680	COG2871	sodium ion transport
ISX50_06685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISX50_06700	COG3118	belongs to the thioredoxin family
ISX50_06705	COG0513	Belongs to the DEAD box helicase family
ISX50_06710	COG0248	Ppx GppA phosphatase
ISX50_06715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISX50_06725	COG0514	ATP-dependent DNA helicase (RecQ)
ISX50_06730	COG2962	Rard protein
ISX50_06740	COG1280	lysine exporter protein (LysE YggA)
ISX50_06745	COG0405	Gamma-glutamyltransferase
ISX50_06755	COG0210	DNA helicase
ISX50_06765	COG3220	belongs to the UPF0276 family
ISX50_06795	COG0006	proline dipeptidase activity
ISX50_06795	COG0006	proline dipeptidase activity
ISX50_06805	COG2022	thiamine diphosphate biosynthetic process
ISX50_06815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISX50_06820	COG0352	thiamine-phosphate diphosphorylase activity
ISX50_06825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ISX50_06835	COG2132	Multicopper oxidase
ISX50_06885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISX50_06890	COG1739	Uncharacterized protein family UPF0029
ISX50_06895	COG1024	Enoyl-CoA hydratase
ISX50_06895	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX50_06900	COG0183	Belongs to the thiolase family
ISX50_06905	COG0604	alcohol dehydrogenase
ISX50_06920	COG0425	Belongs to the sulfur carrier protein TusA family
ISX50_06930	COG2119	membrane
ISX50_06935	COG0752	glycyl-tRNA synthetase alpha subunit
ISX50_06940	COG0751	glycine-tRNA ligase activity
ISX50_06945	COG0366	Alpha amylase catalytic
ISX50_06950	COG3977	Valine--pyruvate aminotransferase
ISX50_06960	COG0187	DNA topoisomerase II activity
ISX50_06965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISX50_06970	COG0592	DNA-directed DNA polymerase activity
ISX50_06975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ISX50_06990	COG1126	abc transporter atp-binding protein
ISX50_06995	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ISX50_07000	COG0594	ribonuclease P activity
ISX50_07005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISX50_07010	COG0706	membrane insertase activity
ISX50_07020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISX50_07025	COG0445	tRNA wobble uridine modification
ISX50_07030	COG0357	Ribosomal RNA small subunit methyltransferase G
ISX50_07035	COG1192	Involved in chromosome partitioning
ISX50_07040	COG1475	DNA binding
ISX50_07045	COG3312	ion transport
ISX50_07060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISX50_07065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISX50_07070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISX50_07075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ISX50_07080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ISX50_07085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISX50_07095	COG3706	GGDEF domain
ISX50_07100	COG2814	Major facilitator Superfamily
ISX50_07105	COG0583	DNA-binding transcription factor activity
ISX50_07115	COG0129	dihydroxy-acid dehydratase activity
ISX50_07120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISX50_07125	COG3978	acetolactate synthase activity
ISX50_07135	COG0606	chelatase, subunit chli
ISX50_07145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISX50_07150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISX50_07160	COG3084	Protein conserved in bacteria
ISX50_07170	COG4326	sporulation control protein
ISX50_07175	COG1272	protein, Hemolysin III
ISX50_07185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISX50_07190	COG0569	domain protein
ISX50_07195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISX50_07195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISX50_07200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISX50_07205	COG0242	peptide deformylase activity
ISX50_07215	COG0758	DNA mediated transformation
ISX50_07220	COG2922	Belongs to the Smg family
ISX50_07225	COG0551	DNA topoisomerase type I activity
ISX50_07230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISX50_07235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISX50_07240	COG0009	L-threonylcarbamoyladenylate synthase
ISX50_07245	COG0408	coproporphyrinogen oxidase activity
ISX50_07250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISX50_07260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISX50_07305	COG0583	DNA-binding transcription factor activity
ISX50_07310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISX50_07315	COG2960	long-chain fatty acid transporting porin activity
ISX50_07320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX50_07325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_07330	COG1309	transcriptional regulator
ISX50_07380	COG0601	transmembrane transport
ISX50_07385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX50_07430	COG1805	sodium ion transport
ISX50_07440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISX50_07445	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISX50_07455	COG1522	sequence-specific DNA binding
ISX50_07460	COG5002	protein histidine kinase activity
ISX50_07460	COG5001	Diguanylate cyclase
ISX50_07465	COG0742	ribosomal rna small subunit methyltransferase
ISX50_07480	COG0589	response to stress
ISX50_07485	COG1528	Iron-storage protein
ISX50_07495	COG2081	HI0933 family
ISX50_07505	COG1322	Protein conserved in bacteria
ISX50_07510	COG2226	methyltransferase
ISX50_07515	COG3165	ubiquinone biosynthetic process from chorismate
ISX50_07520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISX50_07525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISX50_07530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISX50_07535	COG0805	protein transport
ISX50_07540	COG0084	hydrolase, TatD family'
ISX50_07555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISX50_07555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISX50_07580	COG3078	GTPase activator activity
ISX50_07605	COG3852	Histidine kinase
ISX50_07615	COG0174	glutamine synthetase
ISX50_07620	COG1217	gtp-binding protein TYPA
ISX50_07635	COG1295	ribonuclease BN
ISX50_07640	COG1490	D-aminoacyl-tRNA deacylase activity
ISX50_07645	COG0456	acetyltransferase
ISX50_07655	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ISX50_07665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISX50_07670	COG3031	protein transport across the cell outer membrane
ISX50_07680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISX50_07685	COG1459	type II secretion system
ISX50_07690	COG2165	general secretion pathway protein
ISX50_07695	COG2165	general secretion pathway protein
ISX50_07700	COG2165	general secretion pathway protein
ISX50_07705	COG4795	General secretion pathway protein
ISX50_07710	COG3156	type II secretion system protein K
ISX50_07715	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ISX50_07720	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ISX50_07730	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISX50_07735	COG0494	nUDIX hydrolase
ISX50_07740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISX50_07740	COG0316	Belongs to the HesB IscA family
ISX50_07745	COG1040	competence protein
ISX50_07750	COG0596	Alpha beta hydrolase
ISX50_07760	COG2183	response to ionizing radiation
ISX50_07765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISX50_07780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISX50_07785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISX50_07790	COG1758	RNA polymerase activity
ISX50_07795	COG0194	GDP metabolic process
ISX50_07800	COG2252	PERMEase
ISX50_07810	COG1278	Cold shock
ISX50_07815	COG1561	YicC-like family, N-terminal region
ISX50_07820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISX50_07825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISX50_07830	COG1560	Kdo2-lipid A biosynthetic process
ISX50_07835	COG1309	transcriptional regulator
ISX50_07845	COG2003	Belongs to the UPF0758 family
ISX50_07850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ISX50_07855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISX50_07865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISX50_07880	COG0859	PFAM glycosyl transferase family 9
ISX50_07885	COG0463	Glycosyl transferase, family 2
ISX50_07890	COG0859	PFAM glycosyl transferase family 9
ISX50_07895	COG3642	lipopolysaccharide core region biosynthetic process
ISX50_07925	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_07930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISX50_07940	COG1216	Glycosyl transferase, family 2
ISX50_07950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISX50_07965	COG1519	Transferase
ISX50_07970	COG0859	PFAM glycosyl transferase family 9
ISX50_07975	COG1560	Kdo2-lipid A biosynthetic process
ISX50_07995	COG4942	peptidase
ISX50_08000	COG1045	serine acetyltransferase
ISX50_08010	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISX50_08015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX50_08035	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISX50_08040	COG1596	polysaccharide export
ISX50_08080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISX50_08085	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISX50_08095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISX50_08100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISX50_08105	COG2089	acid synthase
ISX50_08115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ISX50_08120	COG1083	cytidylyl-transferase
ISX50_08125	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_08135	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_08180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ISX50_08190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ISX50_08200	COG0534	Mate efflux family protein
ISX50_08220	COG2199	diguanylate cyclase activity
ISX50_08220	COG2203	Gaf domain
ISX50_08225	COG1285	pathogenesis
ISX50_08230	COG1509	lysine 2,3-aminomutase activity
ISX50_08235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISX50_08245	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISX50_08250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISX50_08255	COG1053	succinate dehydrogenase
ISX50_08260	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISX50_08270	COG0471	metal ion transport
ISX50_08270	COG0490	domain, Protein
ISX50_08275	COG0688	phosphatidylethanolamine metabolic process
ISX50_08280	COG1162	GTPase activity
ISX50_08370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISX50_08375	COG0802	atpase or kinase
ISX50_08380	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX50_08385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISX50_08390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISX50_08395	COG1923	regulation of RNA biosynthetic process
ISX50_08400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISX50_08405	COG0330	HflC and HflK could
ISX50_08410	COG0330	HflC and HflK could
ISX50_08420	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISX50_08425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISX50_08430	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ISX50_08435	COG0402	S-adenosylhomocysteine deaminase activity
ISX50_08440	COG0557	exoribonuclease II activity
ISX50_08445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX50_08450	COG0360	Binds together with S18 to 16S ribosomal RNA
ISX50_08460	COG0359	binds to the 23S rRNA
ISX50_08475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISX50_08485	COG0432	Pfam Uncharacterised protein family UPF0047
ISX50_08490	COG0166	Belongs to the GPI family
ISX50_08505	COG0735	belongs to the Fur family
ISX50_08645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISX50_08650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISX50_08655	COG0175	sulfate reduction
ISX50_08735	COG1410	methionine synthase
ISX50_08735	COG0646	methionine synthase
ISX50_08740	COG0527	aspartate kinase activity
ISX50_08745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISX50_08755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISX50_08765	COG2197	response regulator
ISX50_08770	COG0629	single-stranded DNA binding
ISX50_08775	COG2199	diguanylate cyclase activity
ISX50_08775	COG2200	EAL domain
ISX50_08800	COG3267	Type II secretory pathway component ExeA
ISX50_08800	COG3409	Peptidoglycan-binding domain 1 protein
ISX50_08810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISX50_08815	COG1459	type II secretion system
ISX50_08825	COG2165	general secretion pathway protein
ISX50_08830	COG2165	general secretion pathway protein
ISX50_08860	COG1077	Cell shape determining protein MreB Mrl
ISX50_08865	COG1792	Involved in formation and maintenance of cell shape
ISX50_08870	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISX50_08875	COG0424	maF-like protein
ISX50_08890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISX50_08895	COG0312	modulator of DNA gyrase
ISX50_08900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISX50_08905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ISX50_08920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISX50_08925	COG0589	response to stress
ISX50_08940	COG1438	arginine binding
ISX50_08945	COG0039	L-malate dehydrogenase activity
ISX50_08955	COG0142	geranyltranstransferase activity
ISX50_08960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISX50_08965	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISX50_08970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISX50_08975	COG2966	Psort location CytoplasmicMembrane, score
ISX50_08980	COG3610	response to peptide
ISX50_08995	COG2967	ApaG domain
ISX50_09000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISX50_09005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISX50_09010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISX50_09015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISX50_09020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISX50_09035	COG0066	3-isopropylmalate dehydratase activity
ISX50_09040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISX50_09045	COG0473	3-isopropylmalate dehydrogenase activity
ISX50_09050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISX50_09085	COG1022	Amp-dependent synthetase and ligase
ISX50_09090	COG0028	Belongs to the TPP enzyme family
ISX50_09100	COG3706	GGDEF domain
ISX50_09110	COG0469	pyruvate kinase activity
ISX50_09115	COG1349	DNA-binding transcription factor activity
ISX50_09120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISX50_09125	COG2873	o-acetylhomoserine
ISX50_09145	COG1610	YqeY-like protein
ISX50_09150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISX50_09155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ISX50_09160	COG0596	Alpha beta hydrolase
ISX50_09165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ISX50_09170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISX50_09175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISX50_09180	COG1968	undecaprenyl-diphosphatase activity
ISX50_09190	COG3409	Peptidoglycan-binding domain 1 protein
ISX50_09190	COG3267	Type II secretory pathway component ExeA
ISX50_09200	COG4991	sh3 domain protein
ISX50_09205	COG0306	phosphate transporter
ISX50_09210	COG1392	Phosphate transport regulator
ISX50_09215	COG3025	triphosphatase activity
ISX50_09220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISX50_09230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISX50_09235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ISX50_09235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ISX50_09240	COG1538	Outer membrane efflux protein
ISX50_09245	COG0494	nUDIX hydrolase
ISX50_09250	COG3151	Protein conserved in bacteria
ISX50_09260	COG3150	esterase
ISX50_09275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX50_09280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX50_09285	COG3105	Protein conserved in bacteria
ISX50_09290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISX50_09295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ISX50_09300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ISX50_09305	COG0723	plastoquinol--plastocyanin reductase activity
ISX50_09310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISX50_09315	COG2857	Cytochrome c1
ISX50_09320	COG0625	glutathione transferase activity
ISX50_09325	COG2969	positive regulation of protein catabolic process
ISX50_09330	COG2823	Periplasmic or secreted lipoprotein
ISX50_09335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ISX50_09350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISX50_09360	COG0275	rRNA processing
ISX50_09365	COG3116	cell division
ISX50_09370	COG0768	penicillin binding
ISX50_09375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISX50_09380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISX50_09385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISX50_09390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ISX50_09395	COG0772	Belongs to the SEDS family
ISX50_09400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISX50_09405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISX50_09410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISX50_09415	COG0849	cell division
ISX50_09420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISX50_09425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISX50_09430	COG0653	protein targeting
ISX50_09435	COG0494	nUDIX hydrolase
ISX50_09440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ISX50_09445	COG0505	Belongs to the CarA family
ISX50_09450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISX50_09455	COG0730	response to heat
ISX50_09460	COG0583	DNA-binding transcription factor activity
ISX50_09465	COG2860	membrane
ISX50_09480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISX50_09490	COG0493	'glutamate synthase
ISX50_09495	COG0070	glutamate synthase
ISX50_09495	COG0067	glutamate synthase
ISX50_09495	COG0069	glutamate synthase activity
ISX50_09505	COG0070	glutamate synthase
ISX50_09505	COG0067	glutamate synthase
ISX50_09505	COG0069	glutamate synthase activity
ISX50_09510	COG1242	4 iron, 4 sulfur cluster binding
ISX50_09515	COG3706	GGDEF domain
ISX50_09515	COG4251	negative regulation of phosphorylation
ISX50_09515	COG5001	Diguanylate cyclase
ISX50_09515	COG2203	Gaf domain
ISX50_09520	COG5002	protein histidine kinase activity
ISX50_09520	COG0784	Response regulator, receiver
ISX50_09520	COG2198	Histidine kinase
ISX50_09530	COG0745	RESPONSE REGULATOR receiver
ISX50_09540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISX50_09555	COG0083	homoserine kinase activity
ISX50_09560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISX50_09565	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ISX50_09570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ISX50_09575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISX50_09590	COG1115	amino acid carrier protein
ISX50_09595	COG3022	response to hydroperoxide
ISX50_09600	COG0513	Belongs to the DEAD box helicase family
ISX50_09605	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ISX50_09615	COG0716	FMN binding
ISX50_09620	COG4974	Belongs to the 'phage' integrase family
ISX50_09625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISX50_09630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISX50_09645	COG2204	response regulator
ISX50_09665	COG0494	nUDIX hydrolase
ISX50_09675	COG0730	response to heat
ISX50_09680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ISX50_09685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ISX50_09690	COG1283	sodium-dependent phosphate transmembrane transporter activity
ISX50_09695	COG0583	DNA-binding transcription factor activity
ISX50_09700	COG0640	Transcriptional regulator
ISX50_09705	COG0268	Binds directly to 16S ribosomal RNA
ISX50_09710	COG0728	peptidoglycan biosynthetic process
ISX50_09715	COG0196	riboflavin kinase activity
ISX50_09720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ISX50_09730	COG1047	Peptidyl-prolyl cis-trans
ISX50_09735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISX50_09740	COG3279	Response regulator of the LytR AlgR family
ISX50_09745	COG3275	phosphorelay sensor kinase activity
ISX50_09755	COG1966	Carbon starvation protein
ISX50_09765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ISX50_09770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISX50_09780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISX50_09785	COG1605	Chorismate mutase
ISX50_09785	COG0287	Prephenate dehydrogenase
ISX50_09790	COG0739	heme binding
ISX50_09800	COG0488	(ABC) transporter
ISX50_09810	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISX50_09815	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ISX50_09820	COG5001	Diguanylate cyclase
ISX50_09825	COG0077	Prephenate dehydratase
ISX50_09825	COG1605	Chorismate mutase
ISX50_09830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISX50_09835	COG0741	lytic transglycosylase activity
ISX50_09840	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISX50_09845	COG0564	pseudouridine synthase activity
ISX50_09895	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ISX50_09905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISX50_09910	COG0826	peptidase U32
ISX50_09915	COG2974	May be involved in recombination
ISX50_09920	COG0745	RESPONSE REGULATOR receiver
ISX50_09925	COG5002	protein histidine kinase activity
ISX50_09935	COG0248	Ppx GppA phosphatase
ISX50_09940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISX50_09950	COG0581	inorganic phosphate transmembrane transporter activity
ISX50_09955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISX50_09960	COG0704	Plays a role in the regulation of phosphate uptake
ISX50_09980	COG3142	Participates in the control of copper homeostasis
ISX50_09985	COG0450	alkyl hydroperoxide reductase
ISX50_09990	COG0583	DNA-binding transcription factor activity
ISX50_09995	COG0517	IMP dehydrogenase activity
ISX50_10000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISX50_10005	COG0343	queuine tRNA-ribosyltransferase activity
ISX50_10010	COG1862	Preprotein translocase
ISX50_10015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX50_10020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX50_10025	COG0483	inositol monophosphate 1-phosphatase activity
ISX50_10030	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ISX50_10035	COG1959	2 iron, 2 sulfur cluster binding
ISX50_10040	COG1104	cysteine desulfurase activity
ISX50_10045	COG0822	iron-sulfur transferase activity
ISX50_10055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISX50_10060	COG0443	Heat shock 70 kDa protein
ISX50_10070	COG2975	iron-sulfur cluster assembly
ISX50_10075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISX50_10080	COG0105	UTP biosynthetic process
ISX50_10085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISX50_10095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ISX50_10100	COG0124	histidyl-tRNA synthetase
ISX50_10105	COG2976	Protein conserved in bacteria
ISX50_10110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISX50_10115	COG1160	GTP binding
ISX50_10125	COG3706	GGDEF domain
ISX50_10165	COG0831	urea catabolic process
ISX50_10170	COG0832	Belongs to the urease beta subunit family
ISX50_10175	COG0804	urea catabolic process
ISX50_10180	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ISX50_10195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISX50_10200	COG1570	exodeoxyribonuclease VII activity
ISX50_10205	COG0517	IMP dehydrogenase activity
ISX50_10205	COG0516	GMP reductase activity
ISX50_10210	COG0519	Catalyzes the synthesis of GMP from XMP
ISX50_10210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISX50_10220	COG1757	Na H antiporter
ISX50_10230	COG1584	GPR1 FUN34 yaaH family protein
ISX50_10235	COG1115	amino acid carrier protein
ISX50_10240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISX50_10245	COG0204	Acyl-transferase
ISX50_10270	COG0189	ligase activity
ISX50_10270	COG4067	protein conserved in archaea
ISX50_10295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISX50_10315	COG2867	negative regulation of translational initiation
ISX50_10320	COG2914	Belongs to the UPF0125 (RnfH) family
ISX50_10325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISX50_10330	COG0497	DNA recombination
ISX50_10335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISX50_10340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISX50_10355	COG0443	Heat shock 70 kDa protein
ISX50_10360	COG0484	heat shock protein binding
ISX50_10390	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISX50_10395	COG1253	flavin adenine dinucleotide binding
ISX50_10410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISX50_10410	COG0047	phosphoribosylformylglycinamidine synthase activity
ISX50_10420	COG2171	N-acyltransferase activity
ISX50_10430	COG2095	MarC family integral membrane protein
ISX50_10445	COG3141	response to X-ray
ISX50_10460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISX50_10465	COG1074	ATP-dependent DNA helicase activity
ISX50_10470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISX50_10480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISX50_10480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISX50_10490	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISX50_10495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISX50_10500	COG2166	iron-sulfur cluster assembly
ISX50_10505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISX50_10510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISX50_10515	COG3248	Nucleoside-binding outer membrane protein
ISX50_10530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISX50_10540	COG2813	Specifically methylates the guanine in position
ISX50_10545	COG0271	Belongs to the BolA IbaG family
ISX50_10550	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISX50_10555	COG1805	sodium ion transport
ISX50_10565	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISX50_10570	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISX50_10575	COG2871	sodium ion transport
ISX50_10580	COG1477	protein flavinylation
ISX50_10585	COG2991	Protein conserved in bacteria
ISX50_10595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISX50_10600	COG0514	ATP-dependent DNA helicase (RecQ)
ISX50_10615	COG0733	neurotransmitter:sodium symporter activity
ISX50_10620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISX50_10625	COG0321	lipoyl(octanoyl) transferase activity
ISX50_10635	COG1686	Belongs to the peptidase S11 family
ISX50_10640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISX50_10645	COG0772	Belongs to the SEDS family
ISX50_10650	COG0768	penicillin binding
ISX50_10655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISX50_10660	COG0799	negative regulation of ribosome biogenesis
ISX50_10665	COG1466	dna polymerase III delta subunit
ISX50_10670	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ISX50_10675	COG0495	leucyl-tRNA aminoacylation
ISX50_10680	COG2888	peptidyl-tyrosine sulfation
ISX50_10685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISX50_10690	COG4535	Mg2 and Co2 transporter CorC
ISX50_10695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ISX50_10700	COG1702	phosphate starvation-inducible protein PhoH
ISX50_10710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISX50_10715	COG2706	6-phosphogluconolactonase activity
ISX50_10820	COG0193	aminoacyl-tRNA hydrolase activity
ISX50_10825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISX50_10830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISX50_10835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ISX50_10840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISX50_10845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISX50_10850	COG2890	protein-(glutamine-N5) methyltransferase activity
ISX50_10855	COG3094	Invasion gene expression up-regulator, SirB
ISX50_10860	COG2912	Transglutaminase-like superfamily
ISX50_10865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ISX50_10875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISX50_10880	COG1187	pseudouridine synthase activity
ISX50_10885	COG2840	Smr protein MutS2
ISX50_10925	COG2217	Heavy metal translocating P-type atpase
ISX50_10925	COG2608	mercury ion transmembrane transporter activity
ISX50_10945	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_10985	COG1216	Glycosyl transferase, family 2
ISX50_11005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX50_11010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX50_11070	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISX50_11075	COG0784	Response regulator, receiver
ISX50_11075	COG0835	chemotaxis
ISX50_11080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISX50_11085	COG1815	bacterial-type flagellum-dependent cell motility
ISX50_11090	COG1558	bacterial-type flagellum-dependent cell motility
ISX50_11100	COG1749	Flagellar hook protein flgE
ISX50_11105	COG4787	bacterial-type flagellum-dependent cell motility
ISX50_11115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISX50_11120	COG1706	bacterial-type flagellum-dependent cell motility
ISX50_11125	COG1705	Flagellar rod assembly protein muramidase FlgJ
ISX50_11125	COG3951	Flagellar rod assembly protein muramidase FlgJ
ISX50_11145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX50_11150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX50_11155	COG1334	flagellar protein FlaG
ISX50_11160	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISX50_11170	COG1516	flagellar protein fliS
ISX50_11190	COG1677	Flagellar hook-basal body complex protein FliE
ISX50_11200	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ISX50_11250	COG1987	bacterial-type flagellum assembly
ISX50_11255	COG1684	flagellar biosynthetic protein fliR
ISX50_11290	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISX50_11295	COG0643	Histidine kinase
ISX50_11295	COG0784	Response regulator, receiver
ISX50_11295	COG2198	Histidine kinase
ISX50_11300	COG2201	protein-glutamate methylesterase activity
ISX50_11305	COG1192	Involved in chromosome partitioning
ISX50_11315	COG0835	chemotaxis
ISX50_11325	COG4133	protoheme IX ABC transporter activity
ISX50_11330	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISX50_11335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISX50_11340	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISX50_11345	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ISX50_11350	COG1138	Cytochrome C-type biogenesis protein
ISX50_11355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX50_11360	COG3088	subunit of a heme lyase
ISX50_11360	COG4235	cytochrome complex assembly
ISX50_11365	COG3088	subunit of a heme lyase
ISX50_11365	COG4235	cytochrome complex assembly
ISX50_11370	COG2853	Lipoprotein
ISX50_11375	COG2067	long-chain fatty acid transport protein
ISX50_11380	COG2067	long-chain fatty acid transport protein
ISX50_11395	COG0183	Belongs to the thiolase family
ISX50_11400	COG1024	Enoyl-CoA hydratase
ISX50_11400	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX50_11410	COG2062	phosphohistidine phosphatase, SixA
ISX50_11415	COG2840	Smr protein MutS2
ISX50_11420	COG2890	protein-(glutamine-N5) methyltransferase activity
ISX50_11425	COG1280	lysine exporter protein (LysE YggA)
ISX50_11430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISX50_11450	COG1175	transmembrane transport
ISX50_11460	COG3842	ATPase activity
ISX50_11465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISX50_11470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISX50_11470	COG2070	2-Nitropropane dioxygenase
ISX50_11485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISX50_11485	COG3321	synthase
ISX50_11500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISX50_11505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ISX50_11510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ISX50_11520	COG2204	response regulator
ISX50_11535	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISX50_11540	COG0740	serine-type endopeptidase activity
ISX50_11545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISX50_11550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISX50_11555	COG0776	regulation of translation
ISX50_11560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISX50_11565	COG2183	response to ionizing radiation
ISX50_11580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ISX50_11585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ISX50_11590	COG0436	Aminotransferase
ISX50_11595	COG1169	isochorismate synthase
ISX50_11600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ISX50_11605	COG2267	carboxylic ester hydrolase activity
ISX50_11610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISX50_11630	COG2855	membrane
ISX50_11690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX50_11700	COG1454	alcohol dehydrogenase
ISX50_11725	COG0641	radical SAM
ISX50_11735	COG1309	transcriptional regulator
ISX50_11775	COG1902	pentaerythritol trinitrate reductase activity
ISX50_11785	COG1522	sequence-specific DNA binding
ISX50_11795	COG1946	Acyl-CoA thioesterase
ISX50_11800	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISX50_11820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISX50_11820	COG4124	Belongs to the glycosyl hydrolase 26 family
ISX50_11830	COG0583	DNA-binding transcription factor activity
ISX50_11860	COG0583	DNA-binding transcription factor activity
ISX50_11905	COG0328	RNA-DNA hybrid ribonuclease activity
ISX50_11905	COG3341	Caulimovirus viroplasmin
ISX50_11910	COG0438	transferase activity, transferring glycosyl groups
ISX50_11915	COG1216	Glycosyl transferase, family 2
ISX50_11915	COG0463	Glycosyl transferase, family 2
ISX50_11950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISX50_11965	COG0789	Transcriptional regulator
ISX50_11970	COG3394	polysaccharide catabolic process
ISX50_11980	COG0583	DNA-binding transcription factor activity
ISX50_12010	COG3119	arylsulfatase activity
ISX50_12015	COG1609	Transcriptional regulator
ISX50_12020	COG3385	transposase activity
ISX50_12045	COG1760	l-serine dehydratase
ISX50_12050	COG1522	sequence-specific DNA binding
ISX50_12055	COG1280	lysine exporter protein (LysE YggA)
ISX50_12080	COG3708	Transcriptional regulator
ISX50_12080	COG2207	Transcriptional regulator
ISX50_12090	COG2233	PERMEase
ISX50_12095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISX50_12100	COG1227	inorganic diphosphatase activity
ISX50_12120	COG3153	acetyltransferase
ISX50_12165	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISX50_12175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISX50_12190	COG1228	amidohydrolase
ISX50_12205	COG3040	lipid binding
ISX50_12210	COG3038	cytochrome b561
ISX50_12225	COG0583	DNA-binding transcription factor activity
ISX50_12230	COG1309	transcriptional regulator
ISX50_12240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX50_12245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISX50_12250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISX50_12255	COG1845	cytochrome c oxidase, subunit III
ISX50_12260	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISX50_12285	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ISX50_12310	COG0583	DNA-binding transcription factor activity
ISX50_12315	COG0346	lactoylglutathione lyase activity
ISX50_12320	COG1902	pentaerythritol trinitrate reductase activity
ISX50_12350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISX50_12375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ISX50_12375	COG0617	tRNA 3'-terminal CCA addition
ISX50_12375	COG0517	IMP dehydrogenase activity
ISX50_12405	COG0537	adenosine 5'-monophosphoramidase activity
ISX50_12430	COG3150	esterase
ISX50_12435	COG1252	NADH dehydrogenase
ISX50_12450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISX50_12460	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISX50_12465	COG1136	(ABC) transporter
ISX50_12470	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISX50_12480	COG0658	competence protein
ISX50_12480	COG2333	competence protein COMEC
ISX50_12485	COG1132	(ABC) transporter
ISX50_12490	COG1663	tetraacyldisaccharide 4'-kinase activity
ISX50_12495	COG2835	tetraacyldisaccharide 4'-kinase activity
ISX50_12500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ISX50_12505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISX50_12510	COG0539	negative regulation of cytoplasmic translation
ISX50_12515	COG0776	regulation of translation
ISX50_12520	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISX50_12525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISX50_12530	COG0284	orotidine-5'-phosphate decarboxylase activity
ISX50_12545	COG0583	DNA-binding transcription factor activity
ISX50_12560	COG0686	Belongs to the AlaDH PNT family
ISX50_12565	COG1522	sequence-specific DNA binding
ISX50_12570	COG1674	ftsk spoiiie
ISX50_12575	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ISX50_12580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISX50_12585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ISX50_12590	COG0745	RESPONSE REGULATOR receiver
ISX50_12600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX50_12600	COG2205	protein histidine kinase activity
ISX50_12605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISX50_12610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISX50_12615	COG0156	8-amino-7-oxononanoate synthase activity
ISX50_12620	COG2226	methyltransferase
ISX50_12625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISX50_12635	COG0501	Belongs to the peptidase M48B family
ISX50_12640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISX50_12645	COG2915	High frequency lysogenization protein hflD homolog
ISX50_12660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX50_12665	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISX50_12670	COG1757	Na H antiporter
ISX50_12685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISX50_12690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISX50_12690	COG0131	Imidazoleglycerol-phosphate dehydratase
ISX50_12695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISX50_12700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ISX50_12705	COG0107	imidazoleglycerol-phosphate synthase activity
ISX50_12710	COG0140	phosphoribosyl-ATP diphosphatase activity
ISX50_12710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISX50_12715	COG3012	SEC-C Motif Domain Protein
ISX50_12720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ISX50_12725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISX50_12730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISX50_12735	COG0215	cysteine-tRNA ligase activity
ISX50_12765	COG2116	formate transmembrane transporter activity
ISX50_12770	COG0390	transport system, permease component
ISX50_12775	COG4459	periplasmic nitrate reductase
ISX50_12780	COG3005	denitrification pathway
ISX50_12785	COG0243	molybdopterin cofactor binding
ISX50_12795	COG1227	inorganic diphosphatase activity
ISX50_12810	COG4172	Belongs to the ABC transporter superfamily
ISX50_12825	COG4168	peptide transport system, permease
ISX50_12830	COG4166	transmembrane transport
ISX50_12835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISX50_12840	COG1842	Phage shock protein A
ISX50_12850	COG1983	PspC domain protein
ISX50_12855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_12870	COG2818	Glycosylase
ISX50_12885	COG0626	cystathionine gamma-synthase activity
ISX50_12895	COG0733	neurotransmitter:sodium symporter activity
ISX50_12905	COG0564	pseudouridine synthase activity
ISX50_12910	COG0116	Belongs to the methyltransferase superfamily
ISX50_12910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISX50_12915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISX50_12920	COG4136	ATPase activity
ISX50_12925	COG4135	transport system, permease component
ISX50_12930	COG4134	Bacterial extracellular solute-binding protein
ISX50_12940	COG3313	Fe-S protein
ISX50_12960	COG0513	Belongs to the DEAD box helicase family
ISX50_12965	COG1280	lysine exporter protein (LysE YggA)
ISX50_12975	COG2866	Carboxypeptidase
ISX50_13000	COG4176	ABC-type proline glycine betaine transport system permease component
ISX50_13005	COG2113	Glycine betaine
ISX50_13015	COG0583	DNA-binding transcription factor activity
ISX50_13020	COG2995	paraquat-inducible protein a
ISX50_13025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISX50_13025	COG3008	intermembrane lipid transfer
ISX50_13075	COG3842	ATPase activity
ISX50_13095	COG1609	Transcriptional regulator
ISX50_13105	COG0583	DNA-binding transcription factor activity
ISX50_13125	COG0765	amino acid transport
ISX50_13130	COG0765	amino acid transport
ISX50_13140	COG1737	Transcriptional regulator
ISX50_13155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISX50_13170	COG2059	Chromate
ISX50_13175	COG2059	Chromate
ISX50_13190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ISX50_13200	COG0586	Pfam SNARE associated Golgi protein
ISX50_13210	COG0642	Histidine kinase
ISX50_13225	COG1061	Type III restriction enzyme res subunit
ISX50_13235	COG2814	Major facilitator Superfamily
ISX50_13245	COG0702	epimerase
ISX50_13250	COG0534	Mate efflux family protein
ISX50_13270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ISX50_13275	COG3047	cAMP biosynthetic process
ISX50_13275	COG2885	chlorophyll binding
ISX50_13295	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISX50_13300	COG3273	potassium ion transport
ISX50_13300	COG2985	domain, Protein
ISX50_13305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISX50_13315	COG1737	Transcriptional regulator
ISX50_13320	COG0076	glutamate decarboxylase activity
ISX50_13330	COG2431	L-lysine efflux transmembrane transporter activity
ISX50_13340	COG3070	regulator of competence-specific genes
ISX50_13350	COG2204	response regulator
ISX50_13355	COG3852	Histidine kinase
ISX50_13365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISX50_13395	COG1448	Aminotransferase
ISX50_13400	COG3437	response regulator, receiver
ISX50_13400	COG2770	Histidine kinase
ISX50_13410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX50_13420	COG0017	Asparaginyl-tRNA synthetase
ISX50_13430	COG0840	transmembrane signaling receptor activity
ISX50_13440	COG0814	amino acid
ISX50_13445	COG1760	l-serine dehydratase
ISX50_13450	COG0814	amino acid
ISX50_13455	COG0494	nUDIX hydrolase
ISX50_13465	COG5002	protein histidine kinase activity
ISX50_13465	COG0784	Response regulator, receiver
ISX50_13470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISX50_13485	COG3106	COG3106 Predicted ATPase
ISX50_13505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX50_13520	COG0443	Heat shock 70 kDa protein
ISX50_13535	COG3706	GGDEF domain
ISX50_13545	COG3385	transposase activity
ISX50_13570	COG3710	Transcriptional regulator
ISX50_13600	COG1643	Atp-dependent helicase
ISX50_13640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISX50_13645	COG0072	phenylalanine-tRNA ligase activity
ISX50_13645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX50_13710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISX50_13715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISX50_13735	COG2205	protein histidine kinase activity
ISX50_13735	COG0784	Response regulator, receiver
ISX50_13755	COG1464	Belongs to the NlpA lipoprotein family
ISX50_13765	COG1522	sequence-specific DNA binding
ISX50_13810	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISX50_13835	COG0776	regulation of translation
ISX50_13865	COG0583	DNA-binding transcription factor activity
ISX50_13875	COG2175	clavaminate synthase activity
ISX50_13890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX50_13900	COG2988	succinylglutamate desuccinylase activity
ISX50_13905	COG0523	cobalamin synthesis protein
ISX50_13915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISX50_13925	COG0776	regulation of translation
ISX50_13935	COG0500	methyltransferase
ISX50_13945	COG0295	cytidine deaminase activity
ISX50_13950	COG1346	cytolysis
ISX50_13960	COG2925	Exonuclease
ISX50_13995	COG2207	Transcriptional regulator
ISX50_14005	COG3568	Endonuclease Exonuclease Phosphatase
ISX50_14010	COG3122	Protein conserved in bacteria
ISX50_14025	COG4989	oxidoreductase activity
ISX50_14035	COG1823	symporter activity
ISX50_14040	COG0702	epimerase
ISX50_14045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISX50_14050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ISX50_14055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ISX50_14075	COG2988	succinylglutamate desuccinylase activity
ISX50_14080	COG4139	cobalamin transport
ISX50_14085	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ISX50_14105	COG1247	-acetyltransferase
ISX50_14125	COG2814	Major facilitator Superfamily
ISX50_14130	COG0583	DNA-binding transcription factor activity
ISX50_14140	COG1451	nucleotide metabolic process
ISX50_14150	COG3063	Type IV pilus biogenesis stability protein PilW
ISX50_14155	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISX50_14170	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISX50_14175	COG3706	GGDEF domain
ISX50_14195	COG0583	DNA-binding transcription factor activity
ISX50_14215	COG4964	Belongs to the GSP D family
ISX50_14225	COG0455	bacterial-type flagellum organization
ISX50_14270	COG5002	protein histidine kinase activity
ISX50_14270	COG5001	Diguanylate cyclase
ISX50_14275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISX50_14290	COG0840	transmembrane signaling receptor activity
ISX50_14305	COG3469	chitinase activity
ISX50_14315	COG4771	TonB-dependent receptor
ISX50_14320	COG2226	methyltransferase
ISX50_14325	COG2199	diguanylate cyclase activity
ISX50_14330	COG0454	-acetyltransferase
ISX50_14345	COG0420	3'-5' exonuclease activity
ISX50_14350	COG0419	ATPase involved in DNA repair
ISX50_14370	COG3046	protein related to deoxyribodipyrimidine photolyase
ISX50_14375	COG0415	Belongs to the DNA photolyase family
ISX50_14380	COG0589	response to stress
ISX50_14400	COG1120	ATPase activity
ISX50_14405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX50_14415	COG4615	Cyclic peptide transporter
ISX50_14435	COG4774	siderophore transport
ISX50_14455	COG2271	Major facilitator Superfamily
ISX50_14465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISX50_14490	COG0494	nUDIX hydrolase
ISX50_14505	COG1187	pseudouridine synthase activity
ISX50_14515	COG0110	maltose O-acetyltransferase activity
ISX50_14525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISX50_14580	COG1280	lysine exporter protein (LysE YggA)
ISX50_14585	COG0346	lactoylglutathione lyase activity
ISX50_14625	COG0653	protein targeting
ISX50_14635	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_14670	COG0786	glutamate:sodium symporter activity
ISX50_14685	COG0826	peptidase U32
ISX50_14700	COG1126	abc transporter atp-binding protein
ISX50_14705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX50_14710	COG4215	(ABC) transporter
ISX50_14715	COG4160	amino acid transport
ISX50_14790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISX50_14820	COG1742	UPF0060 membrane protein
ISX50_14845	COG0583	DNA-binding transcription factor activity
ISX50_14850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ISX50_14855	COG1215	transferase activity, transferring glycosyl groups
ISX50_14875	COG0110	maltose O-acetyltransferase activity
ISX50_14890	COG2204	response regulator
ISX50_14900	COG4175	Glycine betaine
ISX50_14900	COG3448	diguanylate cyclase activity
ISX50_14905	COG4176	ABC-type proline glycine betaine transport system permease component
ISX50_14925	COG2885	chlorophyll binding
ISX50_14925	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISX50_14940	COG0534	Mate efflux family protein
ISX50_14945	COG0307	riboflavin synthase, alpha
ISX50_14955	COG3001	Fructosamine kinase
ISX50_14965	COG0791	NLP P60 protein
ISX50_14980	COG3148	PFAM DTW domain containing protein
ISX50_14985	COG1940	carbohydrate kinase activity
ISX50_14995	COG0303	'Molybdopterin
ISX50_15000	COG0746	molybdenum cofactor guanylyltransferase activity
ISX50_15005	COG3842	ATPase activity
ISX50_15010	COG4662	Binding-protein-dependent transport system inner membrane component
ISX50_15020	COG2204	response regulator
ISX50_15025	COG4191	Histidine kinase
ISX50_15045	COG0488	(ABC) transporter
ISX50_15050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ISX50_15070	COG3381	protein complex oligomerization
ISX50_15080	COG0243	molybdopterin cofactor binding
ISX50_15080	COG3383	formate dehydrogenase (NAD+) activity
ISX50_15085	COG0437	4 iron, 4 sulfur cluster binding
ISX50_15100	COG0004	ammonium transporteR
ISX50_15105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISX50_15110	COG5001	Diguanylate cyclase
ISX50_15110	COG5002	protein histidine kinase activity
ISX50_15115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISX50_15125	COG1177	transmembrane transport
ISX50_15135	COG3842	ATPase activity
ISX50_15155	COG0037	tRNA processing
ISX50_15160	COG0589	response to stress
ISX50_15165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISX50_15180	COG2217	Heavy metal translocating P-type atpase
ISX50_15190	COG2010	Cytochrome c
ISX50_15205	COG3278	Belongs to the heme-copper respiratory oxidase family
ISX50_15220	COG2205	protein histidine kinase activity
ISX50_15220	COG0784	Response regulator, receiver
ISX50_15405	COG3120	sequence-specific DNA binding
ISX50_15410	COG1067	ATP-dependent peptidase activity
ISX50_15430	COG0488	(ABC) transporter
ISX50_15440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISX50_15440	COG0116	Belongs to the methyltransferase superfamily
ISX50_15450	COG0167	dihydroorotate dehydrogenase activity
ISX50_15455	COG2902	Dehydrogenase
ISX50_15465	COG0308	aminopeptidase N
ISX50_15480	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ISX50_15485	COG1956	GAF domain-containing protein
ISX50_15490	COG1132	(ABC) transporter
ISX50_15495	COG2995	paraquat-inducible protein a
ISX50_15500	COG3008	intermembrane lipid transfer
ISX50_15505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISX50_15505	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ISX50_15510	COG2996	Protein conserved in bacteria
ISX50_15525	COG0574	Belongs to the PEP-utilizing enzyme family
ISX50_15525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISX50_15530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISX50_15535	COG1666	GTP binding
ISX50_15545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX50_15550	COG4597	amino acid ABC transporter
ISX50_15555	COG0765	amino acid transport
ISX50_15560	COG1126	abc transporter atp-binding protein
ISX50_15565	COG0670	Belongs to the BI1 family
ISX50_15570	COG2920	part of a sulfur-relay system
ISX50_15575	COG1254	Belongs to the acylphosphatase family
ISX50_15585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISX50_15655	COG3593	DNA synthesis involved in DNA repair
ISX50_15665	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISX50_15680	COG2964	Protein conserved in bacteria
ISX50_15695	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISX50_15700	COG3639	organic phosphonate transmembrane transporter activity
ISX50_15705	COG2188	Transcriptional regulator
ISX50_15710	COG3624	Phosphonate C-P lyase system protein PhnG
ISX50_15715	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISX50_15720	COG3626	phosphonate metabolism
ISX50_15725	COG3627	carbon phosphorus lyase activity
ISX50_15730	COG4107	phosphonate C-P lyase system protein PhnK
ISX50_15735	COG4778	phosphonate C-P lyase system protein PhnL
ISX50_15740	COG3454	Phosphonate metabolism
ISX50_15750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISX50_15755	COG0110	maltose O-acetyltransferase activity
ISX50_15760	COG0534	Mate efflux family protein
ISX50_15785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISX50_15790	COG2999	glutathione oxidoreductase activity
ISX50_15800	COG0673	inositol 2-dehydrogenase activity
ISX50_15820	COG0584	glycerophosphoryl diester phosphodiesterase
ISX50_15825	COG3842	ATPase activity
ISX50_15830	COG0395	ABC-type sugar transport system, permease component
ISX50_15835	COG1175	transmembrane transport
ISX50_15855	COG4067	protein conserved in archaea
ISX50_15855	COG0189	ligase activity
ISX50_15860	COG0189	ligase activity
ISX50_15900	COG4977	sequence-specific DNA binding
ISX50_15910	COG2814	Major facilitator Superfamily
ISX50_15920	COG0564	pseudouridine synthase activity
ISX50_15945	COG1131	(ABC) transporter
ISX50_15950	COG2186	Transcriptional regulator
ISX50_15955	COG5001	Diguanylate cyclase
ISX50_15965	COG5001	Diguanylate cyclase
ISX50_15975	COG0745	RESPONSE REGULATOR receiver
ISX50_15980	COG2205	protein histidine kinase activity
ISX50_15985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX50_15990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISX50_15995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_16000	COG3037	sugar-specific permease SgaT UlaA
ISX50_16015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISX50_16040	COG0745	RESPONSE REGULATOR receiver
ISX50_16045	COG2205	protein histidine kinase activity
ISX50_16070	COG0513	Belongs to the DEAD box helicase family
ISX50_16085	COG3706	GGDEF domain
ISX50_16090	COG1278	Cold shock
ISX50_16095	COG0402	S-adenosylhomocysteine deaminase activity
ISX50_16100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISX50_16120	COG4413	Urea transporter
ISX50_16135	COG0531	amino acid
ISX50_16150	COG1280	lysine exporter protein (LysE YggA)
ISX50_16165	COG1151	hydroxylamine reductase activity
ISX50_16170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISX50_16195	COG2926	Belongs to the UPF0265 family
ISX50_16205	COG3132	Protein of unknown function, DUF480
ISX50_16210	COG2827	Endonuclease containing a URI domain
ISX50_16240	COG0443	Heat shock 70 kDa protein
ISX50_16250	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISX50_16255	COG1280	lysine exporter protein (LysE YggA)
ISX50_16260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX50_16270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISX50_16280	COG1845	cytochrome c oxidase, subunit III
ISX50_16300	COG1612	heme a metabolic process
ISX50_16305	COG0109	protoheme IX farnesyltransferase activity
ISX50_16325	COG3530	Putative quorum-sensing-regulated virulence factor
ISX50_16330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISX50_16340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX50_16350	COG0668	transmembrane transport
ISX50_16355	COG0569	domain protein
ISX50_16360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISX50_16365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX50_16365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX50_16370	COG1765	OsmC-like protein
ISX50_16375	COG2885	chlorophyll binding
ISX50_16385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISX50_16395	COG1840	ABC-type Fe3 transport system, periplasmic component
ISX50_16400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX50_16405	COG3842	ATPase activity
ISX50_16425	COG2375	cellular response to nickel ion
ISX50_16430	COG3104	oligopeptide transport
ISX50_16435	COG1760	l-serine dehydratase
ISX50_16455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ISX50_16460	COG1132	(ABC) transporter
ISX50_16465	COG1132	(ABC) transporter
ISX50_16490	COG0739	heme binding
ISX50_16495	COG0393	Putative heavy-metal-binding
ISX50_16510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISX50_16515	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISX50_16535	COG0346	lactoylglutathione lyase activity
ISX50_16550	COG2200	EAL domain
ISX50_16555	COG0156	8-amino-7-oxononanoate synthase activity
ISX50_16560	COG1063	alcohol dehydrogenase
ISX50_16580	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISX50_16610	COG1454	alcohol dehydrogenase
ISX50_16615	COG1011	Hydrolase
ISX50_16645	COG1328	CTP reductase activity
ISX50_16650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISX50_16655	COG0583	DNA-binding transcription factor activity
ISX50_16675	COG1289	transmembrane transporter activity
ISX50_16680	COG0210	DNA helicase
ISX50_16690	COG1803	Methylglyoxal synthase
ISX50_16695	COG1879	ABC-type sugar transport system periplasmic component
ISX50_16700	COG0784	Response regulator, receiver
ISX50_16700	COG2198	Histidine kinase
ISX50_16700	COG5002	protein histidine kinase activity
ISX50_16735	COG2223	nitrite transmembrane transporter activity
ISX50_16750	COG0625	glutathione transferase activity
ISX50_16755	COG3064	Membrane
ISX50_16765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_16765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_16765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISX50_16770	COG1105	Belongs to the carbohydrate kinase PfkB family
ISX50_16775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_16775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_16780	COG1609	Transcriptional regulator
ISX50_16785	COG2815	serine threonine protein kinase
ISX50_16785	COG0515	serine threonine protein kinase
ISX50_16790	COG2223	nitrite transmembrane transporter activity
ISX50_16800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISX50_16805	COG0243	molybdopterin cofactor binding
ISX50_16885	COG1609	Transcriptional regulator
ISX50_16890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX50_16895	COG1879	ABC-type sugar transport system periplasmic component
ISX50_16900	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISX50_16905	COG1129	ABC transporter
ISX50_16910	COG1869	D-ribose catabolic process
ISX50_16930	COG4166	transmembrane transport
ISX50_16935	COG4174	ABC transporter (Permease)
ISX50_16940	COG4239	(ABC) transporter, permease
ISX50_16945	COG4172	Belongs to the ABC transporter superfamily
ISX50_16955	COG0583	DNA-binding transcription factor activity
ISX50_16965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISX50_16975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ISX50_16985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISX50_17000	COG0356	it plays a direct role in the translocation of protons across the membrane
ISX50_17010	COG0583	DNA-binding transcription factor activity
ISX50_17020	COG1012	belongs to the aldehyde dehydrogenase family
ISX50_17030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISX50_17070	COG3278	Belongs to the heme-copper respiratory oxidase family
ISX50_17090	COG3300	MHYT domain
ISX50_17090	COG5001	Diguanylate cyclase
ISX50_17100	COG0384	phenazine biosynthesis protein PhzF
ISX50_17125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISX50_17140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ISX50_17155	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ISX50_17175	COG3119	arylsulfatase activity
ISX50_17180	COG3119	arylsulfatase activity
ISX50_17190	COG0714	Associated with various cellular activities
ISX50_17220	COG0583	DNA-binding transcription factor activity
ISX50_17225	COG1597	lipid kinase activity
ISX50_17230	COG5001	Diguanylate cyclase
ISX50_17230	COG3300	MHYT domain
ISX50_17255	COG0641	radical SAM
ISX50_17265	COG0405	Gamma-glutamyltransferase
ISX50_17280	COG0784	Response regulator, receiver
ISX50_17280	COG2205	protein histidine kinase activity
ISX50_17280	COG5002	protein histidine kinase activity
ISX50_17295	COG1132	(ABC) transporter
ISX50_17300	COG1538	Outer membrane efflux protein
ISX50_17305	COG0784	Response regulator, receiver
ISX50_17305	COG2205	protein histidine kinase activity
ISX50_17310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_17345	COG0840	transmembrane signaling receptor activity
ISX50_17380	COG1881	PFAM PEBP family protein
ISX50_17390	COG2807	transmembrane transport
ISX50_17425	COG1280	lysine exporter protein (LysE YggA)
ISX50_17445	COG0534	Mate efflux family protein
ISX50_17470	COG0509	glycine decarboxylation via glycine cleavage system
ISX50_17510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISX50_17515	COG3706	GGDEF domain
ISX50_17520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ISX50_17525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX50_17540	COG0784	Response regulator, receiver
ISX50_17540	COG3437	response regulator, receiver
ISX50_17545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISX50_17555	COG0814	amino acid
ISX50_17560	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ISX50_17565	COG0513	Belongs to the DEAD box helicase family
ISX50_17590	COG2200	EAL domain
ISX50_17605	COG3038	cytochrome b561
ISX50_17610	COG2353	YceI-like domain
ISX50_17615	COG2116	formate transmembrane transporter activity
ISX50_17620	COG0583	DNA-binding transcription factor activity
ISX50_17630	COG3593	DNA synthesis involved in DNA repair
ISX50_17635	COG0737	Belongs to the 5'-nucleotidase family
ISX50_17640	COG0861	Integral membrane protein TerC family
ISX50_17655	COG0513	Belongs to the DEAD box helicase family
ISX50_17670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISX50_17675	COG2272	Belongs to the type-B carboxylesterase lipase family
ISX50_17690	COG1566	PFAM secretion protein HlyD family protein
ISX50_17700	COG2985	domain, Protein
ISX50_17710	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISX50_17725	COG0583	DNA-binding transcription factor activity
ISX50_17740	COG2267	carboxylic ester hydrolase activity
ISX50_17745	COG2067	long-chain fatty acid transport protein
ISX50_17755	COG0501	Belongs to the peptidase M48B family
ISX50_17760	COG2050	protein possibly involved in aromatic compounds catabolism
ISX50_17770	COG4533	DNA binding
ISX50_17800	COG0768	penicillin binding
ISX50_17810	COG1716	ATPase activity
ISX50_17810	COG5001	Diguanylate cyclase
ISX50_17815	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISX50_17825	COG4181	ATPase activity
ISX50_17830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISX50_17840	COG1984	allophanate hydrolase subunit 2
ISX50_17865	COG3300	MHYT domain
ISX50_17865	COG5001	Diguanylate cyclase
ISX50_17875	COG4771	TonB-dependent receptor
ISX50_17875	COG1629	transport
ISX50_17880	COG0583	DNA-binding transcription factor activity
ISX50_17885	COG1042	CoA-binding domain protein
ISX50_17885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX50_17885	COG0045	succinate-CoA ligase (ADP-forming) activity
ISX50_17890	COG3266	domain, Protein
ISX50_17895	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISX50_17910	COG0023	Translation Initiation Factor
ISX50_17945	COG3140	Belongs to the UPF0181 family
ISX50_18045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISX50_18050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISX50_18065	COG3706	GGDEF domain
ISX50_18075	COG4251	negative regulation of phosphorylation
ISX50_18075	COG3706	GGDEF domain
ISX50_18075	COG2203	Gaf domain
ISX50_18075	COG5001	Diguanylate cyclase
ISX50_18085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISX50_18090	COG4149	molybdate abc transporter
ISX50_18095	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISX50_18115	COG0488	(ABC) transporter
ISX50_18120	COG4067	protein conserved in archaea
ISX50_18120	COG0189	ligase activity
ISX50_18130	COG0602	queuosine metabolic process
ISX50_18135	COG1328	CTP reductase activity
ISX50_18145	COG2391	methyltransferase activity
ISX50_18165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX50_18170	COG3118	belongs to the thioredoxin family
ISX50_18180	COG0318	PFAM AMP-dependent synthetase and ligase
ISX50_18210	COG0534	Mate efflux family protein
ISX50_18235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISX50_18235	COG1321	iron dependent repressor
ISX50_18240	COG1121	(ABC) transporter
ISX50_18245	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISX50_18290	COG0848	biopolymer transport protein
ISX50_18295	COG0811	peptide transport
ISX50_18300	COG0811	peptide transport
ISX50_18310	COG4774	siderophore transport
ISX50_18315	COG1301	dicarboxylic acid transport
ISX50_18320	COG2205	protein histidine kinase activity
ISX50_18325	COG0745	RESPONSE REGULATOR receiver
ISX50_18340	COG1648	precorrin-2 dehydrogenase activity
ISX50_18340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISX50_18345	COG2116	formate transmembrane transporter activity
ISX50_18355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISX50_18410	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ISX50_18420	COG0494	nUDIX hydrolase
ISX50_18425	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISX50_18475	COG3706	GGDEF domain
ISX50_18505	COG1929	Belongs to the glycerate kinase type-1 family
ISX50_18510	COG0383	alpha-mannosidase activity
ISX50_18515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_18515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_18515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_18520	COG2188	Transcriptional regulator
ISX50_18545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX50_18550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_18555	COG2067	long-chain fatty acid transport protein
ISX50_18560	COG2267	carboxylic ester hydrolase activity
ISX50_18575	COG3069	C4-dicarboxylate transmembrane transporter activity
ISX50_18580	COG2197	response regulator
ISX50_18585	COG3850	Histidine kinase
ISX50_18600	COG0243	molybdopterin cofactor binding
ISX50_18630	COG0183	Belongs to the thiolase family
ISX50_18675	COG0745	RESPONSE REGULATOR receiver
ISX50_18710	COG0513	Belongs to the DEAD box helicase family
ISX50_18715	COG0523	cobalamin synthesis protein
ISX50_18720	COG0038	chloride channel
ISX50_18730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISX50_18740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISX50_18745	COG1175	transmembrane transport
ISX50_18755	COG1609	Transcriptional regulator
ISX50_18760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISX50_18760	COG1017	nitric oxide dioxygenase activity
ISX50_18765	COG3604	Transcriptional regulator
ISX50_18785	COG0545	Peptidyl-prolyl cis-trans isomerase
ISX50_18790	COG1309	transcriptional regulator
ISX50_18795	COG2130	NADP-dependent
ISX50_18805	COG0564	pseudouridine synthase activity
ISX50_18815	COG1686	Belongs to the peptidase S11 family
ISX50_18830	COG3706	GGDEF domain
ISX50_18840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISX50_18850	COG3059	membrane
ISX50_18875	COG0251	oxidation-reduction process
ISX50_18890	COG2207	Transcriptional regulator
ISX50_18895	COG1979	alcohol dehydrogenase
ISX50_18900	COG1126	abc transporter atp-binding protein
ISX50_18905	COG0765	amino acid transport
ISX50_18915	COG0765	amino acid transport
ISX50_18930	COG3708	Transcriptional regulator
ISX50_18930	COG2207	Transcriptional regulator
ISX50_18940	COG1280	lysine exporter protein (LysE YggA)
ISX50_18970	COG2824	Alkylphosphonate utilization operon protein PhnA
ISX50_18990	COG5297	Belongs to the glycosyl hydrolase family 6
ISX50_18990	COG2273	Hydrolase Family 16
ISX50_19010	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX50_19040	COG1132	(ABC) transporter
ISX50_19045	COG1132	(ABC) transporter
ISX50_19055	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISX50_19055	COG1902	pentaerythritol trinitrate reductase activity
ISX50_19065	COG3710	Transcriptional regulator
ISX50_19080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX50_19085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_19095	COG2985	domain, Protein
ISX50_19115	COG1024	Enoyl-CoA hydratase
ISX50_19130	COG4774	siderophore transport
ISX50_19145	COG1120	ATPase activity
ISX50_19155	COG2133	pyrroloquinoline quinone binding
ISX50_19160	COG1278	Cold shock
ISX50_19165	COG4681	YaeQ
ISX50_19175	COG0302	gtp cyclohydrolase
ISX50_19205	COG2897	thiosulfate sulfurtransferase activity
ISX50_19210	COG4251	negative regulation of phosphorylation
ISX50_19210	COG2203	Gaf domain
ISX50_19210	COG3706	GGDEF domain
ISX50_19210	COG5001	Diguanylate cyclase
ISX50_19245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISX50_19255	COG3385	transposase activity
ISX50_19260	COG0840	transmembrane signaling receptor activity
ISX50_19265	COG1522	sequence-specific DNA binding
ISX50_19285	COG2814	Major facilitator Superfamily
ISX50_19290	COG0583	DNA-binding transcription factor activity
ISX50_19295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX50_19295	COG0784	Response regulator, receiver
ISX50_19295	COG2198	Histidine kinase
ISX50_19295	COG2205	protein histidine kinase activity
ISX50_19300	COG3437	response regulator, receiver
ISX50_19305	COG4604	ABC transporter, ATP-binding protein
ISX50_19310	COG4605	iron ion homeostasis
ISX50_19315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX50_19320	COG4607	ABC-type enterochelin transport system periplasmic component
ISX50_19345	COG0628	permease
ISX50_19355	COG1566	PFAM secretion protein HlyD family protein
ISX50_19365	COG3706	GGDEF domain
ISX50_19390	COG0402	S-adenosylhomocysteine deaminase activity
ISX50_19405	COG0583	DNA-binding transcription factor activity
ISX50_19425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ISX50_19430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISX50_19435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISX50_19440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX50_19445	COG1116	anion transmembrane transporter activity
ISX50_19450	COG0351	phosphomethylpyrimidine kinase
ISX50_19455	COG0697	spore germination
ISX50_19500	COG2205	protein histidine kinase activity
ISX50_19525	COG0628	permease
ISX50_19550	COG1785	Belongs to the alkaline phosphatase family
ISX50_19560	COG0516	GMP reductase activity
ISX50_19585	COG0534	Mate efflux family protein
ISX50_19590	COG0583	DNA-binding transcription factor activity
ISX50_19595	COG0366	Alpha amylase catalytic
ISX50_19610	COG0697	spore germination
ISX50_19630	COG0604	alcohol dehydrogenase
ISX50_19675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ISX50_19680	COG0513	Belongs to the DEAD box helicase family
ISX50_19685	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ISX50_19700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISX50_19735	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISX50_19745	COG0667	Aldo Keto reductase
ISX50_19750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX50_19755	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISX50_19760	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ISX50_19765	COG0513	Belongs to the DEAD box helicase family
ISX50_19775	COG2176	DNA-directed DNA polymerase activity
ISX50_19790	COG0513	Belongs to the DEAD box helicase family
ISX50_19795	COG4989	oxidoreductase activity
ISX50_19815	COG1538	Outer membrane efflux protein
ISX50_19820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_19865	COG0668	transmembrane transport
ISX50_19875	COG4232	protein-disulfide reductase activity
ISX50_19880	COG3118	belongs to the thioredoxin family
ISX50_19895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISX50_19900	COG0697	spore germination
ISX50_19915	COG2814	Major facilitator Superfamily
ISX50_19920	COG0583	DNA-binding transcription factor activity
ISX50_19925	COG5001	Diguanylate cyclase
ISX50_19930	COG0739	heme binding
ISX50_19955	COG3314	Sporulation integral membrane protein YlbJ
ISX50_19965	COG0366	Alpha amylase catalytic
ISX50_19970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISX50_19975	COG0835	chemotaxis
ISX50_19975	COG0784	Response regulator, receiver
ISX50_19980	COG2096	Adenosyltransferase
ISX50_19985	COG0748	coenzyme F420 binding
ISX50_19990	COG3721	Heme iron utilization protein
ISX50_20000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISX50_20005	COG0811	peptide transport
ISX50_20010	COG0848	biopolymer transport protein
ISX50_20020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX50_20025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISX50_20070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISX50_20075	COG0633	Ferredoxin
ISX50_20075	COG3217	Mosc domain protein beta barrel domain protein
ISX50_20085	COG0418	dihydroorotase activity
ISX50_20090	COG2354	Protein conserved in bacteria
ISX50_20100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISX50_20115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ISX50_20115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ISX50_20120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ISX50_20125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISX50_20130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX50_20160	COG0730	response to heat
ISX50_20165	COG0280	phosphate acetyltransferase
ISX50_20170	COG1414	Transcriptional regulator
ISX50_20175	COG1012	belongs to the aldehyde dehydrogenase family
ISX50_20220	COG0583	DNA-binding transcription factor activity
ISX50_20245	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_20260	COG3706	GGDEF domain
ISX50_20280	COG0583	DNA-binding transcription factor activity
ISX50_20300	COG1136	(ABC) transporter
ISX50_20305	COG0577	efflux transmembrane transporter activity
ISX50_20325	COG3119	arylsulfatase activity
ISX50_20335	COG0641	radical SAM
ISX50_20345	COG0583	DNA-binding transcription factor activity
ISX50_20355	COG0387	Pfam Sodium calcium exchanger
ISX50_20365	COG2239	Acts as a magnesium transporter
ISX50_20385	COG0668	transmembrane transport
ISX50_20395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX50_20400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX50_20440	COG3833	ABC-type maltose transport systems, permease component
ISX50_20445	COG1175	transmembrane transport
ISX50_20455	COG3842	ATPase activity
ISX50_20465	COG0840	transmembrane signaling receptor activity
ISX50_20470	COG0714	Associated with various cellular activities
ISX50_20485	COG2304	oxidoreductase activity
ISX50_20490	COG2304	oxidoreductase activity
ISX50_20505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISX50_20510	COG0581	inorganic phosphate transmembrane transporter activity
ISX50_20515	COG0573	inorganic phosphate transmembrane transporter activity
ISX50_20525	COG0840	transmembrane signaling receptor activity
ISX50_20530	COG5380	lipid catabolic process
ISX50_20535	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ISX50_20540	COG3240	lipase activity
ISX50_20545	COG0513	Belongs to the DEAD box helicase family
ISX50_20555	COG1388	LysM domain
ISX50_20555	COG1376	ErfK ybiS ycfS ynhG family protein
ISX50_20560	COG0813	purine-nucleoside phosphorylase activity
ISX50_20590	COG1566	PFAM secretion protein HlyD family protein
ISX50_20595	COG4720	Psort location CytoplasmicMembrane, score
ISX50_20600	COG1122	ATPase activity
ISX50_20615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISX50_20620	COG1640	4-alpha-glucanotransferase
ISX50_20625	COG0058	SHG alpha-glucan phosphorylase activity
ISX50_20630	COG2909	trisaccharide binding
ISX50_20645	COG1999	signal sequence binding
ISX50_20655	COG1162	GTPase activity
ISX50_20660	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ISX50_20700	COG3258	Cytochrome c
ISX50_20740	COG4580	involved in the transport of maltose and maltodextrins
ISX50_20755	COG2384	SAM-dependent methyltransferase
ISX50_20760	COG0204	Acyl-transferase
ISX50_20770	COG3615	Tellurite resistance protein tehB
ISX50_20775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISX50_20780	COG4667	esterase of the alpha-beta hydrolase superfamily
ISX50_20785	COG0753	catalase activity
ISX50_20790	COG1929	Belongs to the glycerate kinase type-1 family
ISX50_20800	COG3623	hexulose-6-phosphate isomerase
ISX50_20805	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ISX50_20810	COG0561	phosphatase activity
ISX50_20875	COG0583	DNA-binding transcription factor activity
ISX50_20880	COG3214	Protein conserved in bacteria
ISX50_20890	COG0561	phosphatase activity
ISX50_20915	COG0798	PFAM Bile acid sodium symporter
ISX50_20920	COG0583	DNA-binding transcription factor activity
ISX50_20930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISX50_20935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISX50_20940	COG1349	DNA-binding transcription factor activity
ISX50_20945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISX50_20950	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_20955	COG0583	DNA-binding transcription factor activity
ISX50_20965	COG1794	racemase activity, acting on amino acids and derivatives
ISX50_20985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISX50_20995	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISX50_21015	COG3119	arylsulfatase activity
ISX50_21020	COG0641	radical SAM
ISX50_21025	COG0583	DNA-binding transcription factor activity
ISX50_21030	COG2814	Major facilitator Superfamily
ISX50_21070	COG0110	maltose O-acetyltransferase activity
ISX50_21075	COG1609	Transcriptional regulator
ISX50_21080	COG2723	6-phospho-beta-galactosidase activity
ISX50_21095	COG0346	lactoylglutathione lyase activity
ISX50_21110	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ISX50_21115	COG0583	DNA-binding transcription factor activity
ISX50_21120	COG0534	Mate efflux family protein
ISX50_21125	COG1024	Enoyl-CoA hydratase
ISX50_21130	COG0300	oxidoreductase activity
ISX50_21140	COG2723	6-phospho-beta-galactosidase activity
ISX50_21145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX50_21145	COG1263	PTS System
ISX50_21150	COG3265	gluconokinase activity
ISX50_21155	COG0129	dihydroxy-acid dehydratase activity
ISX50_21160	COG1609	Transcriptional regulator
ISX50_21215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISX50_21215	COG0646	methionine synthase
ISX50_21240	COG3321	synthase
ISX50_21240	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_21240	COG0604	alcohol dehydrogenase
ISX50_21250	COG2814	Major facilitator Superfamily
ISX50_21255	COG2207	Transcriptional regulator
ISX50_21270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ISX50_21290	COG2207	Transcriptional regulator
ISX50_21305	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ISX50_21305	COG3408	Glycogen debranching enzyme
ISX50_21310	COG2169	Transcriptional regulator
ISX50_21315	COG1486	melibiose metabolic process
ISX50_21320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISX50_21350	COG1846	Transcriptional regulator
ISX50_21375	COG1012	belongs to the aldehyde dehydrogenase family
ISX50_21380	COG1309	transcriptional regulator
ISX50_21390	COG0745	RESPONSE REGULATOR receiver
ISX50_21395	COG2205	protein histidine kinase activity
ISX50_21415	COG0579	oxidoreductase
ISX50_21430	COG2204	response regulator
ISX50_21445	COG0800	Aldolase
ISX50_21450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX50_21455	COG4145	pantothenate transmembrane transporter activity
ISX50_21465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ISX50_21490	COG2194	sulfuric ester hydrolase activity
ISX50_21515	COG1132	(ABC) transporter
ISX50_21520	COG4399	Belongs to the UPF0754 family
ISX50_21550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_21575	COG0259	pyridoxamine-phosphate oxidase activity
ISX50_21615	COG1444	tRNA N-acetyltransferase activity
ISX50_21640	COG4608	Belongs to the ABC transporter superfamily
ISX50_21645	COG0444	Belongs to the ABC transporter superfamily
ISX50_21655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISX50_21655	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ISX50_21670	COG4221	oxidoreductase activity
ISX50_21685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX50_21700	COG0765	amino acid transport
ISX50_21710	COG3385	transposase activity
ISX50_21740	COG3842	ATPase activity
ISX50_21750	COG0745	RESPONSE REGULATOR receiver
ISX50_21755	COG2205	protein histidine kinase activity
ISX50_21775	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISX50_21785	COG0625	glutathione transferase activity
ISX50_21790	COG1609	Transcriptional regulator
ISX50_21795	COG0483	inositol monophosphate 1-phosphatase activity
ISX50_21800	COG1234	tRNA 3'-trailer cleavage
ISX50_21805	COG3842	ATPase activity
ISX50_21815	COG1175	transmembrane transport
ISX50_21835	COG0625	glutathione transferase activity
ISX50_21855	COG3321	synthase
ISX50_21855	COG4221	oxidoreductase activity
ISX50_21855	COG0604	alcohol dehydrogenase
ISX50_21855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISX50_21860	COG0583	DNA-binding transcription factor activity
ISX50_21865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISX50_21870	COG3186	Phenylalanine-4-hydroxylase
ISX50_21885	COG0217	transcriptional regulatory protein
ISX50_21900	COG2084	Dehydrogenase
ISX50_21915	COG0583	DNA-binding transcription factor activity
ISX50_21930	COG1136	(ABC) transporter
ISX50_21935	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISX50_21950	COG3275	phosphorelay sensor kinase activity
ISX50_21955	COG3279	Response regulator of the LytR AlgR family
ISX50_21960	COG0612	Peptidase, M16
ISX50_21970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX50_21975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX50_21990	COG1902	pentaerythritol trinitrate reductase activity
ISX50_21995	COG2814	Major facilitator Superfamily
ISX50_22000	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_22020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISX50_22030	COG0724	RNA recognition motif
ISX50_22055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISX50_22070	COG4221	oxidoreductase activity
ISX50_22080	COG0415	Belongs to the DNA photolyase family
ISX50_22090	COG3806	Anti-sigma factor
ISX50_22095	COG1595	DNA-templated transcription, initiation
ISX50_22105	COG1942	4-Oxalocrotonate Tautomerase
ISX50_22120	COG0786	glutamate:sodium symporter activity
ISX50_22125	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISX50_22150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_22150	COG2213	PTS system mannitol-specific
ISX50_22155	COG0246	Mannitol dehydrogenase
ISX50_22160	COG3722	fumarate hydratase activity
ISX50_22165	COG0363	glucosamine-6-phosphate deaminase activity
ISX50_22185	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISX50_22200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISX50_22210	COG3366	ferrous iron transmembrane transporter activity
ISX50_22215	COG0700	Nucleoside recognition
ISX50_22220	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISX50_22265	COG0596	Alpha beta hydrolase
ISX50_22280	COG3123	guanosine phosphorylase activity
ISX50_22285	COG1741	Belongs to the pirin family
ISX50_22320	COG0745	RESPONSE REGULATOR receiver
ISX50_22335	COG1054	Belongs to the UPF0176 family
ISX50_22350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX50_22355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX50_22355	COG2207	Transcriptional regulator
ISX50_22360	COG0534	Mate efflux family protein
ISX50_22370	COG4172	Belongs to the ABC transporter superfamily
ISX50_22375	COG0747	negative chemotaxis
ISX50_22395	COG1304	FMN binding
ISX50_22400	COG1620	l-lactate permease
ISX50_22405	COG0583	DNA-binding transcription factor activity
ISX50_22410	COG1505	serine-type exopeptidase activity
ISX50_22440	COG0395	ABC-type sugar transport system, permease component
ISX50_22445	COG2723	6-phospho-beta-galactosidase activity
ISX50_22450	COG3842	ATPase activity
ISX50_22455	COG3459	Glycosyltransferase 36 associated
ISX50_22460	COG2017	converts alpha-aldose to the beta-anomer
ISX50_22470	COG1609	Transcriptional regulator
ISX50_22475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISX50_22480	COG1482	cell wall glycoprotein biosynthetic process
ISX50_22485	COG0246	Mannitol dehydrogenase
ISX50_22490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_22495	COG1312	Catalyzes the dehydration of D-mannonate
ISX50_22500	COG0110	maltose O-acetyltransferase activity
ISX50_22510	COG2186	Transcriptional regulator
ISX50_22515	COG4172	Belongs to the ABC transporter superfamily
ISX50_22525	COG1067	ATP-dependent peptidase activity
ISX50_22575	COG0583	DNA-binding transcription factor activity
ISX50_22585	COG1846	Transcriptional regulator
ISX50_22595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISX50_22600	COG3960	tartronate-semialdehyde synthase activity
ISX50_22605	COG3622	Belongs to the hyi family
ISX50_22610	COG2084	Dehydrogenase
ISX50_22625	COG0402	S-adenosylhomocysteine deaminase activity
ISX50_22650	COG2252	PERMEase
ISX50_22670	COG4266	Belongs to the allantoicase family
ISX50_22675	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ISX50_22705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISX50_22725	COG0789	Transcriptional regulator
ISX50_22730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISX50_22740	COG0402	S-adenosylhomocysteine deaminase activity
ISX50_22750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISX50_22775	COG1418	mRNA catabolic process
ISX50_22780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISX50_22785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISX50_22830	COG0583	DNA-binding transcription factor activity
ISX50_22840	COG3655	Transcriptional regulator
ISX50_22845	COG0625	glutathione transferase activity
ISX50_22865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISX50_22870	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ISX50_22875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISX50_22900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX50_22905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_22910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISX50_22915	COG1136	(ABC) transporter
ISX50_22915	COG0577	efflux transmembrane transporter activity
ISX50_22920	COG2205	protein histidine kinase activity
ISX50_22925	COG0745	RESPONSE REGULATOR receiver
ISX50_22935	COG1882	Formate acetyltransferase
ISX50_22945	COG1609	Transcriptional regulator
ISX50_22950	COG0584	glycerophosphoryl diester phosphodiesterase
ISX50_22960	COG0395	ABC-type sugar transport system, permease component
ISX50_22985	COG4303	Ethanolamine ammonia lyase large subunit
ISX50_22995	COG0531	amino acid
ISX50_23010	COG1609	Transcriptional regulator
ISX50_23015	COG4948	Mandelate Racemase Muconate Lactonizing
ISX50_23035	COG0698	ribose 5-phosphate isomerase
ISX50_23045	COG4166	transmembrane transport
ISX50_23050	COG0583	DNA-binding transcription factor activity
ISX50_23075	COG0546	phosphoglycolate phosphatase activity
ISX50_23080	COG3842	ATPase activity
ISX50_23085	COG0765	amino acid transport
ISX50_23095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_23110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX50_23110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_23110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_23115	COG2207	Transcriptional regulator
ISX50_23120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX50_23130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_23135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX50_23150	COG0840	transmembrane signaling receptor activity
ISX50_23155	COG0814	amino acid
ISX50_23160	COG2814	Major facilitator Superfamily
ISX50_23175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX50_23190	COG0840	transmembrane signaling receptor activity
ISX50_23200	COG0583	DNA-binding transcription factor activity
ISX50_23225	COG0583	DNA-binding transcription factor activity
ISX50_23235	COG4948	Mandelate Racemase Muconate Lactonizing
ISX50_23260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ISX50_23265	COG3639	organic phosphonate transmembrane transporter activity
ISX50_23270	COG3639	organic phosphonate transmembrane transporter activity
ISX50_23315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ISX50_23320	COG3047	cAMP biosynthetic process
ISX50_23330	COG4221	oxidoreductase activity
ISX50_23335	COG0583	DNA-binding transcription factor activity
ISX50_23340	COG1733	regulation of RNA biosynthetic process
ISX50_23345	COG1028	Short-chain dehydrogenase reductase Sdr
ISX50_23365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISX50_23395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX50_23400	COG1595	DNA-templated transcription, initiation
ISX50_23425	COG1901	pseudouridine methyltransferase