locus-tag	class	description
ITG09_00010	COG2871	sodium ion transport
ITG09_00015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ITG09_00030	COG3118	belongs to the thioredoxin family
ITG09_00035	COG0513	Belongs to the DEAD box helicase family
ITG09_00040	COG0248	Ppx GppA phosphatase
ITG09_00045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ITG09_00055	COG0514	ATP-dependent DNA helicase (RecQ)
ITG09_00060	COG2962	Rard protein
ITG09_00070	COG1280	lysine exporter protein (LysE YggA)
ITG09_00075	COG0405	Gamma-glutamyltransferase
ITG09_00085	COG0210	DNA helicase
ITG09_00095	COG3220	belongs to the UPF0276 family
ITG09_00125	COG0006	proline dipeptidase activity
ITG09_00125	COG0006	proline dipeptidase activity
ITG09_00135	COG2022	thiamine diphosphate biosynthetic process
ITG09_00140	COG2104	thiamine diphosphate biosynthetic process
ITG09_00145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG09_00150	COG0352	thiamine-phosphate diphosphorylase activity
ITG09_00155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ITG09_00165	COG2132	Multicopper oxidase
ITG09_00215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG09_00225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ITG09_00230	COG0408	coproporphyrinogen oxidase activity
ITG09_00235	COG0009	L-threonylcarbamoyladenylate synthase
ITG09_00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ITG09_00245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ITG09_00250	COG0551	DNA topoisomerase type I activity
ITG09_00255	COG2922	Belongs to the Smg family
ITG09_00260	COG0758	DNA mediated transformation
ITG09_00270	COG0242	peptide deformylase activity
ITG09_00275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ITG09_00280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG09_00280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG09_00285	COG0569	domain protein
ITG09_00290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG09_00300	COG1272	protein, Hemolysin III
ITG09_00305	COG4326	sporulation control protein
ITG09_00315	COG3084	Protein conserved in bacteria
ITG09_00325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITG09_00330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG09_00340	COG0606	chelatase, subunit chli
ITG09_00350	COG3978	acetolactate synthase activity
ITG09_00355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG09_00360	COG0129	dihydroxy-acid dehydratase activity
ITG09_00370	COG0583	DNA-binding transcription factor activity
ITG09_00375	COG2814	Major facilitator Superfamily
ITG09_00385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG09_00390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ITG09_00395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG09_00400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ITG09_00405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG09_00410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ITG09_00425	COG3312	ion transport
ITG09_00430	COG1475	DNA binding
ITG09_00435	COG1192	Involved in chromosome partitioning
ITG09_00440	COG0357	Ribosomal RNA small subunit methyltransferase G
ITG09_00445	COG0445	tRNA wobble uridine modification
ITG09_00450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG09_00460	COG0706	membrane insertase activity
ITG09_00465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ITG09_00470	COG0594	ribonuclease P activity
ITG09_00475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ITG09_00480	COG1126	abc transporter atp-binding protein
ITG09_00495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ITG09_00500	COG0592	DNA-directed DNA polymerase activity
ITG09_00505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITG09_00510	COG0187	DNA topoisomerase II activity
ITG09_00520	COG3977	Valine--pyruvate aminotransferase
ITG09_00525	COG0366	Alpha amylase catalytic
ITG09_00530	COG0751	glycine-tRNA ligase activity
ITG09_00535	COG0752	glycyl-tRNA synthetase alpha subunit
ITG09_00540	COG2119	membrane
ITG09_00550	COG0425	Belongs to the sulfur carrier protein TusA family
ITG09_00565	COG0604	alcohol dehydrogenase
ITG09_00570	COG0183	Belongs to the thiolase family
ITG09_00575	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG09_00575	COG1024	Enoyl-CoA hydratase
ITG09_00580	COG1739	Uncharacterized protein family UPF0029
ITG09_00585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG09_00630	COG0583	DNA-binding transcription factor activity
ITG09_00635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ITG09_00640	COG2960	long-chain fatty acid transporting porin activity
ITG09_00645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG09_00650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_00655	COG1309	transcriptional regulator
ITG09_00705	COG0601	transmembrane transport
ITG09_00710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG09_00755	COG1805	sodium ion transport
ITG09_00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG09_00770	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ITG09_00775	COG0339	signal peptide processing
ITG09_00780	COG1522	sequence-specific DNA binding
ITG09_00785	COG5002	protein histidine kinase activity
ITG09_00785	COG5001	Diguanylate cyclase
ITG09_00790	COG0742	ribosomal rna small subunit methyltransferase
ITG09_00805	COG0589	response to stress
ITG09_00810	COG1528	Iron-storage protein
ITG09_00820	COG2081	HI0933 family
ITG09_00830	COG1322	Protein conserved in bacteria
ITG09_00835	COG2226	methyltransferase
ITG09_00840	COG3165	ubiquinone biosynthetic process from chorismate
ITG09_00845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG09_00850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG09_00855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG09_00860	COG0805	protein transport
ITG09_00865	COG0084	hydrolase, TatD family'
ITG09_00880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG09_00880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG09_00905	COG3078	GTPase activator activity
ITG09_00930	COG3852	Histidine kinase
ITG09_00940	COG0174	glutamine synthetase
ITG09_00945	COG1217	gtp-binding protein TYPA
ITG09_00950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ITG09_00960	COG1295	ribonuclease BN
ITG09_00965	COG1490	D-aminoacyl-tRNA deacylase activity
ITG09_00970	COG0456	acetyltransferase
ITG09_00980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ITG09_00990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ITG09_00995	COG3031	protein transport across the cell outer membrane
ITG09_01005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG09_01010	COG1459	type II secretion system
ITG09_01015	COG2165	general secretion pathway protein
ITG09_01020	COG2165	general secretion pathway protein
ITG09_01025	COG2165	general secretion pathway protein
ITG09_01030	COG4795	General secretion pathway protein
ITG09_01035	COG3156	type II secretion system protein K
ITG09_01040	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG09_01045	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG09_01060	COG1218	3'(2'),5'-bisphosphate nucleotidase
ITG09_01065	COG0494	nUDIX hydrolase
ITG09_01070	COG0316	Belongs to the HesB IscA family
ITG09_01070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ITG09_01075	COG1040	competence protein
ITG09_01080	COG0596	Alpha beta hydrolase
ITG09_01090	COG2183	response to ionizing radiation
ITG09_01095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG09_01110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ITG09_01115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG09_01120	COG1758	RNA polymerase activity
ITG09_01125	COG0194	GDP metabolic process
ITG09_01130	COG2252	PERMEase
ITG09_01140	COG1278	Cold shock
ITG09_01145	COG1561	YicC-like family, N-terminal region
ITG09_01150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ITG09_01155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ITG09_01160	COG1560	Kdo2-lipid A biosynthetic process
ITG09_01165	COG1309	transcriptional regulator
ITG09_01175	COG2003	Belongs to the UPF0758 family
ITG09_01180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ITG09_01185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ITG09_01195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ITG09_01205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG09_01215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ITG09_01225	COG0463	Glycosyl transferase, family 2
ITG09_01230	COG0859	PFAM glycosyl transferase family 9
ITG09_01235	COG3642	lipopolysaccharide core region biosynthetic process
ITG09_01245	COG1086	Polysaccharide biosynthesis protein
ITG09_01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITG09_01255	COG1083	cytidylyl-transferase
ITG09_01270	COG2089	acid synthase
ITG09_01285	COG1519	Transferase
ITG09_01290	COG0859	PFAM glycosyl transferase family 9
ITG09_01295	COG1560	Kdo2-lipid A biosynthetic process
ITG09_01315	COG4942	peptidase
ITG09_01320	COG1045	serine acetyltransferase
ITG09_01330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ITG09_01335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG09_01355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG09_01365	COG2801	Transposase and inactivated derivatives
ITG09_01370	COG1596	polysaccharide export
ITG09_01410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ITG09_01430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITG09_01445	COG1216	Glycosyl transferase, family 2
ITG09_01460	COG0438	transferase activity, transferring glycosyl groups
ITG09_01465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG09_01475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITG09_01485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ITG09_01495	COG0534	Mate efflux family protein
ITG09_01500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ITG09_01515	COG2199	diguanylate cyclase activity
ITG09_01520	COG1285	pathogenesis
ITG09_01525	COG1509	lysine 2,3-aminomutase activity
ITG09_01530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG09_01540	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ITG09_01545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG09_01550	COG1053	succinate dehydrogenase
ITG09_01555	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ITG09_01565	COG0840	transmembrane signaling receptor activity
ITG09_01570	COG0471	metal ion transport
ITG09_01570	COG0490	domain, Protein
ITG09_01575	COG0688	phosphatidylethanolamine metabolic process
ITG09_01580	COG1162	GTPase activity
ITG09_01670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ITG09_01675	COG0802	atpase or kinase
ITG09_01680	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITG09_01685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ITG09_01690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ITG09_01695	COG1923	regulation of RNA biosynthetic process
ITG09_01700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG09_01705	COG0330	HflC and HflK could
ITG09_01710	COG0330	HflC and HflK could
ITG09_01715	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ITG09_01720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG09_01725	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ITG09_01730	COG0402	S-adenosylhomocysteine deaminase activity
ITG09_01735	COG0557	exoribonuclease II activity
ITG09_01740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG09_01745	COG0360	Binds together with S18 to 16S ribosomal RNA
ITG09_01755	COG0359	binds to the 23S rRNA
ITG09_01770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITG09_01780	COG0432	Pfam Uncharacterised protein family UPF0047
ITG09_01785	COG0166	Belongs to the GPI family
ITG09_01795	COG0735	belongs to the Fur family
ITG09_01800	COG3385	transposase activity
ITG09_01810	COG0583	DNA-binding transcription factor activity
ITG09_01835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG09_01840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG09_01845	COG0175	sulfate reduction
ITG09_01930	COG0646	methionine synthase
ITG09_01930	COG1410	methionine synthase
ITG09_01935	COG0527	aspartate kinase activity
ITG09_01940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITG09_01950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ITG09_01960	COG2197	response regulator
ITG09_01965	COG0629	single-stranded DNA binding
ITG09_01970	COG2200	EAL domain
ITG09_01970	COG2199	diguanylate cyclase activity
ITG09_01995	COG3267	Type II secretory pathway component ExeA
ITG09_01995	COG3409	Peptidoglycan-binding domain 1 protein
ITG09_02005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG09_02010	COG1459	type II secretion system
ITG09_02020	COG2165	general secretion pathway protein
ITG09_02025	COG2165	general secretion pathway protein
ITG09_02055	COG1077	Cell shape determining protein MreB Mrl
ITG09_02060	COG1792	Involved in formation and maintenance of cell shape
ITG09_02065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ITG09_02070	COG0424	maF-like protein
ITG09_02085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITG09_02090	COG0312	modulator of DNA gyrase
ITG09_02095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ITG09_02100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITG09_02115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG09_02120	COG0589	response to stress
ITG09_02135	COG1438	arginine binding
ITG09_02140	COG0039	L-malate dehydrogenase activity
ITG09_02150	COG0142	geranyltranstransferase activity
ITG09_02155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ITG09_02160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ITG09_02165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ITG09_02170	COG2966	Psort location CytoplasmicMembrane, score
ITG09_02175	COG3610	response to peptide
ITG09_02190	COG2967	ApaG domain
ITG09_02195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ITG09_02200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ITG09_02205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG09_02210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ITG09_02215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG09_02230	COG0066	3-isopropylmalate dehydratase activity
ITG09_02240	COG0473	3-isopropylmalate dehydrogenase activity
ITG09_02245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITG09_02280	COG1022	Amp-dependent synthetase and ligase
ITG09_02285	COG0028	Belongs to the TPP enzyme family
ITG09_02295	COG3706	GGDEF domain
ITG09_02305	COG0469	pyruvate kinase activity
ITG09_02310	COG1349	DNA-binding transcription factor activity
ITG09_02315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ITG09_02320	COG2873	o-acetylhomoserine
ITG09_02335	COG2378	regulation of single-species biofilm formation
ITG09_02390	COG0582	viral genome integration into host DNA
ITG09_02400	COG2205	protein histidine kinase activity
ITG09_02480	COG1610	YqeY-like protein
ITG09_02485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ITG09_02490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ITG09_02495	COG0596	Alpha beta hydrolase
ITG09_02500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ITG09_02505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG09_02510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG09_02515	COG1968	undecaprenyl-diphosphatase activity
ITG09_02525	COG3267	Type II secretory pathway component ExeA
ITG09_02525	COG3409	Peptidoglycan-binding domain 1 protein
ITG09_02535	COG4991	sh3 domain protein
ITG09_02540	COG0306	phosphate transporter
ITG09_02545	COG1392	Phosphate transport regulator
ITG09_02550	COG3025	triphosphatase activity
ITG09_02555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG09_02565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ITG09_02570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ITG09_02570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ITG09_02580	COG1538	Outer membrane efflux protein
ITG09_02585	COG0494	nUDIX hydrolase
ITG09_02590	COG3151	Protein conserved in bacteria
ITG09_02600	COG3150	esterase
ITG09_02615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG09_02620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG09_02625	COG3105	Protein conserved in bacteria
ITG09_02630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ITG09_02635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ITG09_02640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ITG09_02645	COG0723	plastoquinol--plastocyanin reductase activity
ITG09_02650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITG09_02655	COG2857	Cytochrome c1
ITG09_02660	COG0625	glutathione transferase activity
ITG09_02665	COG2969	positive regulation of protein catabolic process
ITG09_02675	COG2823	Periplasmic or secreted lipoprotein
ITG09_02680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG09_02695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ITG09_02705	COG0275	rRNA processing
ITG09_02710	COG3116	cell division
ITG09_02715	COG0768	penicillin binding
ITG09_02720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG09_02725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ITG09_02730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG09_02735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ITG09_02740	COG0772	Belongs to the SEDS family
ITG09_02745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ITG09_02750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG09_02755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ITG09_02760	COG0849	cell division
ITG09_02765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ITG09_02770	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ITG09_02775	COG0653	protein targeting
ITG09_02780	COG0494	nUDIX hydrolase
ITG09_02785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ITG09_02790	COG0505	Belongs to the CarA family
ITG09_02795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITG09_02800	COG0730	response to heat
ITG09_02805	COG0583	DNA-binding transcription factor activity
ITG09_02810	COG2860	membrane
ITG09_02825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG09_02835	COG0493	'glutamate synthase
ITG09_02840	COG0070	glutamate synthase
ITG09_02840	COG0069	glutamate synthase activity
ITG09_02840	COG0067	glutamate synthase
ITG09_02850	COG0067	glutamate synthase
ITG09_02850	COG0069	glutamate synthase activity
ITG09_02850	COG0070	glutamate synthase
ITG09_02855	COG1242	4 iron, 4 sulfur cluster binding
ITG09_02860	COG2203	Gaf domain
ITG09_02860	COG3706	GGDEF domain
ITG09_02860	COG4251	negative regulation of phosphorylation
ITG09_02860	COG5001	Diguanylate cyclase
ITG09_02865	COG2198	Histidine kinase
ITG09_02865	COG5002	protein histidine kinase activity
ITG09_02865	COG0784	Response regulator, receiver
ITG09_02875	COG0745	RESPONSE REGULATOR receiver
ITG09_02885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG09_02900	COG0083	homoserine kinase activity
ITG09_02905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ITG09_02980	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ITG09_02990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ITG09_02995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ITG09_03010	COG1115	amino acid carrier protein
ITG09_03015	COG3022	response to hydroperoxide
ITG09_03020	COG0513	Belongs to the DEAD box helicase family
ITG09_03025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ITG09_03035	COG0716	FMN binding
ITG09_03040	COG4974	Belongs to the 'phage' integrase family
ITG09_03045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG09_03050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITG09_03085	COG0494	nUDIX hydrolase
ITG09_03095	COG0730	response to heat
ITG09_03100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ITG09_03105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ITG09_03110	COG1283	sodium-dependent phosphate transmembrane transporter activity
ITG09_03115	COG0583	DNA-binding transcription factor activity
ITG09_03120	COG0640	Transcriptional regulator
ITG09_03125	COG0268	Binds directly to 16S ribosomal RNA
ITG09_03130	COG0728	peptidoglycan biosynthetic process
ITG09_03135	COG0196	riboflavin kinase activity
ITG09_03140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG09_03150	COG1047	Peptidyl-prolyl cis-trans
ITG09_03155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ITG09_03160	COG3279	Response regulator of the LytR AlgR family
ITG09_03165	COG3275	phosphorelay sensor kinase activity
ITG09_03170	COG3385	transposase activity
ITG09_03175	COG1966	Carbon starvation protein
ITG09_03185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ITG09_03190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ITG09_03200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG09_03205	COG0287	Prephenate dehydrogenase
ITG09_03205	COG1605	Chorismate mutase
ITG09_03210	COG0739	heme binding
ITG09_03220	COG0488	(ABC) transporter
ITG09_03230	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ITG09_03235	COG3385	transposase activity
ITG09_03240	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ITG09_03245	COG5001	Diguanylate cyclase
ITG09_03250	COG0077	Prephenate dehydratase
ITG09_03250	COG1605	Chorismate mutase
ITG09_03255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG09_03265	COG0741	lytic transglycosylase activity
ITG09_03270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG09_03275	COG0564	pseudouridine synthase activity
ITG09_03320	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ITG09_03330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG09_03335	COG0826	peptidase U32
ITG09_03340	COG2974	May be involved in recombination
ITG09_03345	COG0745	RESPONSE REGULATOR receiver
ITG09_03350	COG5002	protein histidine kinase activity
ITG09_03360	COG0248	Ppx GppA phosphatase
ITG09_03365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ITG09_03375	COG0581	inorganic phosphate transmembrane transporter activity
ITG09_03380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG09_03385	COG0704	Plays a role in the regulation of phosphate uptake
ITG09_03395	COG3385	transposase activity
ITG09_03410	COG3142	Participates in the control of copper homeostasis
ITG09_03415	COG0450	alkyl hydroperoxide reductase
ITG09_03420	COG0583	DNA-binding transcription factor activity
ITG09_03425	COG0517	IMP dehydrogenase activity
ITG09_03430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ITG09_03435	COG0343	queuine tRNA-ribosyltransferase activity
ITG09_03440	COG1862	Preprotein translocase
ITG09_03445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG09_03450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG09_03455	COG0483	inositol monophosphate 1-phosphatase activity
ITG09_03460	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ITG09_03465	COG1959	2 iron, 2 sulfur cluster binding
ITG09_03470	COG1104	cysteine desulfurase activity
ITG09_03475	COG0822	iron-sulfur transferase activity
ITG09_03485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG09_03490	COG0443	Heat shock 70 kDa protein
ITG09_03500	COG2975	iron-sulfur cluster assembly
ITG09_03505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG09_03510	COG0105	UTP biosynthetic process
ITG09_03515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ITG09_03525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ITG09_03530	COG0124	histidyl-tRNA synthetase
ITG09_03535	COG2976	Protein conserved in bacteria
ITG09_03540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG09_03545	COG1160	GTP binding
ITG09_03555	COG3706	GGDEF domain
ITG09_03595	COG0831	urea catabolic process
ITG09_03600	COG0832	Belongs to the urease beta subunit family
ITG09_03605	COG0804	urea catabolic process
ITG09_03610	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ITG09_03625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ITG09_03630	COG1570	exodeoxyribonuclease VII activity
ITG09_03635	COG0517	IMP dehydrogenase activity
ITG09_03635	COG0516	GMP reductase activity
ITG09_03640	COG0519	Catalyzes the synthesis of GMP from XMP
ITG09_03640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ITG09_03650	COG1757	Na H antiporter
ITG09_03655	COG1584	GPR1 FUN34 yaaH family protein
ITG09_03660	COG1115	amino acid carrier protein
ITG09_03665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ITG09_03670	COG0204	Acyl-transferase
ITG09_03740	COG2391	methyltransferase activity
ITG09_03755	COG0189	ligase activity
ITG09_03755	COG4067	protein conserved in archaea
ITG09_03770	COG2867	negative regulation of translational initiation
ITG09_03775	COG2914	Belongs to the UPF0125 (RnfH) family
ITG09_03780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG09_03785	COG0497	DNA recombination
ITG09_03790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ITG09_03795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ITG09_03810	COG0443	Heat shock 70 kDa protein
ITG09_03815	COG0484	heat shock protein binding
ITG09_03845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG09_03850	COG1253	flavin adenine dinucleotide binding
ITG09_03865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITG09_03865	COG0047	phosphoribosylformylglycinamidine synthase activity
ITG09_03875	COG2171	N-acyltransferase activity
ITG09_03885	COG2095	MarC family integral membrane protein
ITG09_03900	COG3141	response to X-ray
ITG09_03915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ITG09_03920	COG1074	ATP-dependent DNA helicase activity
ITG09_03925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG09_03935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ITG09_03935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG09_03945	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ITG09_03950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ITG09_03955	COG2166	iron-sulfur cluster assembly
ITG09_03960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG09_03965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITG09_03970	COG3248	Nucleoside-binding outer membrane protein
ITG09_03985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG09_03995	COG2813	Specifically methylates the guanine in position
ITG09_04000	COG0271	Belongs to the BolA IbaG family
ITG09_04005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG09_04010	COG1805	sodium ion transport
ITG09_04020	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG09_04025	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG09_04030	COG2871	sodium ion transport
ITG09_04035	COG1477	protein flavinylation
ITG09_04040	COG2991	Protein conserved in bacteria
ITG09_04050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG09_04070	COG0733	neurotransmitter:sodium symporter activity
ITG09_04075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ITG09_04080	COG0321	lipoyl(octanoyl) transferase activity
ITG09_04090	COG1686	Belongs to the peptidase S11 family
ITG09_04095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG09_04100	COG0772	Belongs to the SEDS family
ITG09_04105	COG0768	penicillin binding
ITG09_04110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ITG09_04115	COG0799	negative regulation of ribosome biogenesis
ITG09_04120	COG1466	dna polymerase III delta subunit
ITG09_04125	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ITG09_04130	COG0495	leucyl-tRNA aminoacylation
ITG09_04135	COG2888	peptidyl-tyrosine sulfation
ITG09_04140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ITG09_04145	COG4535	Mg2 and Co2 transporter CorC
ITG09_04150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ITG09_04155	COG1702	phosphate starvation-inducible protein PhoH
ITG09_04165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG09_04170	COG2706	6-phosphogluconolactonase activity
ITG09_04275	COG0193	aminoacyl-tRNA hydrolase activity
ITG09_04280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ITG09_04285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ITG09_04290	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ITG09_04295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ITG09_04300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ITG09_04305	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG09_04310	COG3094	Invasion gene expression up-regulator, SirB
ITG09_04315	COG2912	Transglutaminase-like superfamily
ITG09_04320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ITG09_04330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ITG09_04335	COG1187	pseudouridine synthase activity
ITG09_04340	COG2840	Smr protein MutS2
ITG09_04380	COG2608	mercury ion transmembrane transporter activity
ITG09_04380	COG2217	Heavy metal translocating P-type atpase
ITG09_04400	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_04440	COG1216	Glycosyl transferase, family 2
ITG09_04460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG09_04465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG09_04525	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ITG09_04530	COG0784	Response regulator, receiver
ITG09_04530	COG0835	chemotaxis
ITG09_04535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ITG09_04540	COG1815	bacterial-type flagellum-dependent cell motility
ITG09_04545	COG1558	bacterial-type flagellum-dependent cell motility
ITG09_04555	COG1749	Flagellar hook protein flgE
ITG09_04560	COG4787	bacterial-type flagellum-dependent cell motility
ITG09_04570	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG09_04575	COG1706	bacterial-type flagellum-dependent cell motility
ITG09_04580	COG3951	Flagellar rod assembly protein muramidase FlgJ
ITG09_04580	COG1705	Flagellar rod assembly protein muramidase FlgJ
ITG09_04600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG09_04605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG09_04610	COG1334	flagellar protein FlaG
ITG09_04615	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG09_04625	COG1516	flagellar protein fliS
ITG09_04645	COG1677	Flagellar hook-basal body complex protein FliE
ITG09_04655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITG09_04705	COG1987	bacterial-type flagellum assembly
ITG09_04710	COG1684	flagellar biosynthetic protein fliR
ITG09_04745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ITG09_04750	COG0643	Histidine kinase
ITG09_04750	COG0784	Response regulator, receiver
ITG09_04750	COG2198	Histidine kinase
ITG09_04755	COG2201	protein-glutamate methylesterase activity
ITG09_04760	COG1192	Involved in chromosome partitioning
ITG09_04770	COG0835	chemotaxis
ITG09_04780	COG4133	protoheme IX ABC transporter activity
ITG09_04785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG09_04790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG09_04795	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG09_04800	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ITG09_04805	COG1138	Cytochrome C-type biogenesis protein
ITG09_04810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITG09_04815	COG3088	subunit of a heme lyase
ITG09_04815	COG4235	cytochrome complex assembly
ITG09_04820	COG3088	subunit of a heme lyase
ITG09_04820	COG4235	cytochrome complex assembly
ITG09_04825	COG2853	Lipoprotein
ITG09_04835	COG2067	long-chain fatty acid transport protein
ITG09_04850	COG0183	Belongs to the thiolase family
ITG09_04855	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG09_04855	COG1024	Enoyl-CoA hydratase
ITG09_04865	COG2062	phosphohistidine phosphatase, SixA
ITG09_04870	COG2840	Smr protein MutS2
ITG09_04875	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG09_04880	COG1280	lysine exporter protein (LysE YggA)
ITG09_04885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ITG09_04905	COG1175	transmembrane transport
ITG09_04915	COG3842	ATPase activity
ITG09_04920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG09_04925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ITG09_04925	COG2070	2-Nitropropane dioxygenase
ITG09_04940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG09_04940	COG3321	synthase
ITG09_04955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG09_04960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG09_04965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG09_04975	COG2204	response regulator
ITG09_04990	COG0544	peptidyl-prolyl cis-trans isomerase activity
ITG09_04995	COG0740	serine-type endopeptidase activity
ITG09_05000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ITG09_05005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ITG09_05010	COG0776	regulation of translation
ITG09_05015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG09_05020	COG1555	photosystem II stabilization
ITG09_05035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ITG09_05040	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ITG09_05045	COG0436	Aminotransferase
ITG09_05050	COG1169	isochorismate synthase
ITG09_05055	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ITG09_05060	COG2267	carboxylic ester hydrolase activity
ITG09_05065	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ITG09_05085	COG2855	membrane
ITG09_05145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG09_05155	COG1454	alcohol dehydrogenase
ITG09_05185	COG0641	radical SAM
ITG09_05195	COG1309	transcriptional regulator
ITG09_05235	COG1902	pentaerythritol trinitrate reductase activity
ITG09_05240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITG09_05245	COG1522	sequence-specific DNA binding
ITG09_05255	COG1946	Acyl-CoA thioesterase
ITG09_05260	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ITG09_05305	COG1061	Type III restriction enzyme res subunit
ITG09_05320	COG3385	transposase activity
ITG09_05345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITG09_05385	COG0215	cysteine-tRNA ligase activity
ITG09_05400	COG0583	DNA-binding transcription factor activity
ITG09_05420	COG1263	PTS System
ITG09_05420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG09_05430	COG1621	beta-fructofuranosidase activity
ITG09_05435	COG3385	transposase activity
ITG09_05440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ITG09_05440	COG4124	Belongs to the glycosyl hydrolase 26 family
ITG09_05455	COG1228	amidohydrolase
ITG09_05475	COG1566	PFAM secretion protein HlyD family protein
ITG09_05490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG09_05525	COG3341	Caulimovirus viroplasmin
ITG09_05525	COG0328	RNA-DNA hybrid ribonuclease activity
ITG09_05530	COG0438	transferase activity, transferring glycosyl groups
ITG09_05535	COG0463	Glycosyl transferase, family 2
ITG09_05535	COG1216	Glycosyl transferase, family 2
ITG09_05570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG09_05585	COG0789	Transcriptional regulator
ITG09_05590	COG3394	polysaccharide catabolic process
ITG09_05600	COG0583	DNA-binding transcription factor activity
ITG09_05625	COG3119	arylsulfatase activity
ITG09_05630	COG1609	Transcriptional regulator
ITG09_05655	COG1760	l-serine dehydratase
ITG09_05660	COG1522	sequence-specific DNA binding
ITG09_05690	COG3708	Transcriptional regulator
ITG09_05690	COG2207	Transcriptional regulator
ITG09_05700	COG2233	PERMEase
ITG09_05705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG09_05710	COG1227	inorganic diphosphatase activity
ITG09_05740	COG3153	acetyltransferase
ITG09_05785	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG09_05795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG09_05810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG09_05815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG09_05820	COG1120	ATPase activity
ITG09_05830	COG1228	amidohydrolase
ITG09_05835	COG3040	lipid binding
ITG09_05840	COG3038	cytochrome b561
ITG09_05855	COG0583	DNA-binding transcription factor activity
ITG09_05860	COG1309	transcriptional regulator
ITG09_05870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG09_05875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG09_05880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG09_05885	COG1845	cytochrome c oxidase, subunit III
ITG09_05890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITG09_05905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG09_05930	COG0583	DNA-binding transcription factor activity
ITG09_05935	COG0346	lactoylglutathione lyase activity
ITG09_05940	COG1902	pentaerythritol trinitrate reductase activity
ITG09_05970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG09_05995	COG0617	tRNA 3'-terminal CCA addition
ITG09_05995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ITG09_05995	COG0517	IMP dehydrogenase activity
ITG09_06025	COG0537	adenosine 5'-monophosphoramidase activity
ITG09_06050	COG3150	esterase
ITG09_06055	COG1252	NADH dehydrogenase
ITG09_06070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ITG09_06080	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG09_06085	COG1136	(ABC) transporter
ITG09_06090	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG09_06100	COG0658	competence protein
ITG09_06100	COG2333	competence protein COMEC
ITG09_06105	COG1132	(ABC) transporter
ITG09_06110	COG1663	tetraacyldisaccharide 4'-kinase activity
ITG09_06115	COG2835	tetraacyldisaccharide 4'-kinase activity
ITG09_06120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ITG09_06125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ITG09_06130	COG0539	negative regulation of cytoplasmic translation
ITG09_06135	COG0776	regulation of translation
ITG09_06140	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ITG09_06145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ITG09_06150	COG0284	orotidine-5'-phosphate decarboxylase activity
ITG09_06165	COG0583	DNA-binding transcription factor activity
ITG09_06175	COG0686	Belongs to the AlaDH PNT family
ITG09_06180	COG1522	sequence-specific DNA binding
ITG09_06185	COG1674	ftsk spoiiie
ITG09_06190	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ITG09_06195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ITG09_06200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ITG09_06215	COG0784	Response regulator, receiver
ITG09_06215	COG2205	protein histidine kinase activity
ITG09_06220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITG09_06225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ITG09_06230	COG0156	8-amino-7-oxononanoate synthase activity
ITG09_06235	COG2226	methyltransferase
ITG09_06240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ITG09_06250	COG0501	Belongs to the peptidase M48B family
ITG09_06255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ITG09_06260	COG2915	High frequency lysogenization protein hflD homolog
ITG09_06275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG09_06280	COG2916	Histone family protein nucleoid-structuring protein H-NS
ITG09_06285	COG1757	Na H antiporter
ITG09_06300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG09_06305	COG0131	Imidazoleglycerol-phosphate dehydratase
ITG09_06305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG09_06310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ITG09_06315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ITG09_06320	COG0107	imidazoleglycerol-phosphate synthase activity
ITG09_06325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ITG09_06325	COG0140	phosphoribosyl-ATP diphosphatase activity
ITG09_06330	COG3012	SEC-C Motif Domain Protein
ITG09_06335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG09_06340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG09_06345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG09_06350	COG0215	cysteine-tRNA ligase activity
ITG09_06380	COG2116	formate transmembrane transporter activity
ITG09_06385	COG0390	transport system, permease component
ITG09_06390	COG4459	periplasmic nitrate reductase
ITG09_06395	COG3005	denitrification pathway
ITG09_06400	COG0243	molybdopterin cofactor binding
ITG09_06410	COG1227	inorganic diphosphatase activity
ITG09_06425	COG4172	Belongs to the ABC transporter superfamily
ITG09_06440	COG4168	peptide transport system, permease
ITG09_06445	COG4166	transmembrane transport
ITG09_06450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITG09_06455	COG1842	Phage shock protein A
ITG09_06465	COG1983	PspC domain protein
ITG09_06470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_06485	COG2818	Glycosylase
ITG09_06500	COG0626	cystathionine gamma-synthase activity
ITG09_06510	COG0733	neurotransmitter:sodium symporter activity
ITG09_06520	COG0564	pseudouridine synthase activity
ITG09_06525	COG0116	Belongs to the methyltransferase superfamily
ITG09_06525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG09_06530	COG3385	transposase activity
ITG09_06535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ITG09_06540	COG4136	ATPase activity
ITG09_06545	COG4135	transport system, permease component
ITG09_06550	COG4134	Bacterial extracellular solute-binding protein
ITG09_06560	COG3313	Fe-S protein
ITG09_06580	COG0513	Belongs to the DEAD box helicase family
ITG09_06585	COG1280	lysine exporter protein (LysE YggA)
ITG09_06595	COG2866	Carboxypeptidase
ITG09_06605	COG3005	denitrification pathway
ITG09_06610	COG0243	molybdopterin cofactor binding
ITG09_06630	COG4176	ABC-type proline glycine betaine transport system permease component
ITG09_06635	COG2113	Glycine betaine
ITG09_06645	COG0583	DNA-binding transcription factor activity
ITG09_06655	COG2995	paraquat-inducible protein a
ITG09_06660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG09_06660	COG3008	intermembrane lipid transfer
ITG09_06700	COG3842	ATPase activity
ITG09_06720	COG1609	Transcriptional regulator
ITG09_06730	COG0583	DNA-binding transcription factor activity
ITG09_06755	COG2026	Addiction module toxin, RelE StbE family
ITG09_06855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ITG09_06865	COG0586	Pfam SNARE associated Golgi protein
ITG09_06875	COG0642	Histidine kinase
ITG09_06890	COG1061	Type III restriction enzyme res subunit
ITG09_06900	COG2814	Major facilitator Superfamily
ITG09_06910	COG0702	epimerase
ITG09_06915	COG0534	Mate efflux family protein
ITG09_06935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG09_06940	COG2885	chlorophyll binding
ITG09_06940	COG3047	cAMP biosynthetic process
ITG09_06960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG09_06965	COG2985	domain, Protein
ITG09_06965	COG3273	potassium ion transport
ITG09_06970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG09_06980	COG1737	Transcriptional regulator
ITG09_06985	COG0076	glutamate decarboxylase activity
ITG09_06995	COG2431	L-lysine efflux transmembrane transporter activity
ITG09_07005	COG3070	regulator of competence-specific genes
ITG09_07015	COG2204	response regulator
ITG09_07020	COG3852	Histidine kinase
ITG09_07030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ITG09_07045	COG2258	MOSC domain
ITG09_07065	COG1448	Aminotransferase
ITG09_07070	COG3437	response regulator, receiver
ITG09_07070	COG2770	Histidine kinase
ITG09_07080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG09_07090	COG0017	Asparaginyl-tRNA synthetase
ITG09_07095	COG0659	secondary active sulfate transmembrane transporter activity
ITG09_07100	COG0840	transmembrane signaling receptor activity
ITG09_07110	COG0814	amino acid
ITG09_07115	COG1760	l-serine dehydratase
ITG09_07120	COG0814	amino acid
ITG09_07125	COG0494	nUDIX hydrolase
ITG09_07135	COG0784	Response regulator, receiver
ITG09_07135	COG5002	protein histidine kinase activity
ITG09_07140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG09_07155	COG3106	COG3106 Predicted ATPase
ITG09_07170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG09_07185	COG0443	Heat shock 70 kDa protein
ITG09_07200	COG3706	GGDEF domain
ITG09_07230	COG3710	Transcriptional regulator
ITG09_07260	COG1643	Atp-dependent helicase
ITG09_07300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ITG09_07305	COG0072	phenylalanine-tRNA ligase activity
ITG09_07305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG09_07350	COG0302	gtp cyclohydrolase
ITG09_07355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG09_07360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG09_07375	COG1464	Belongs to the NlpA lipoprotein family
ITG09_07430	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ITG09_07455	COG0776	regulation of translation
ITG09_07475	COG0840	transmembrane signaling receptor activity
ITG09_07485	COG0583	DNA-binding transcription factor activity
ITG09_07495	COG2175	clavaminate synthase activity
ITG09_07510	COG2988	succinylglutamate desuccinylase activity
ITG09_07515	COG0523	cobalamin synthesis protein
ITG09_07525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG09_07535	COG0776	regulation of translation
ITG09_07545	COG0500	methyltransferase
ITG09_07555	COG0295	cytidine deaminase activity
ITG09_07560	COG1346	cytolysis
ITG09_07570	COG2925	Exonuclease
ITG09_07615	COG3568	Endonuclease Exonuclease Phosphatase
ITG09_07625	COG3122	Protein conserved in bacteria
ITG09_07640	COG4989	oxidoreductase activity
ITG09_07650	COG1823	symporter activity
ITG09_07655	COG0702	epimerase
ITG09_07660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ITG09_07665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ITG09_07670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ITG09_07690	COG2988	succinylglutamate desuccinylase activity
ITG09_07695	COG4139	cobalamin transport
ITG09_07700	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ITG09_07710	COG0747	negative chemotaxis
ITG09_07715	COG0601	transmembrane transport
ITG09_07720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG09_07745	COG1247	-acetyltransferase
ITG09_07765	COG2814	Major facilitator Superfamily
ITG09_07770	COG0583	DNA-binding transcription factor activity
ITG09_07780	COG1451	nucleotide metabolic process
ITG09_07790	COG3063	Type IV pilus biogenesis stability protein PilW
ITG09_07795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ITG09_07810	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG09_07815	COG3706	GGDEF domain
ITG09_07840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITG09_07845	COG1999	signal sequence binding
ITG09_07875	COG0583	DNA-binding transcription factor activity
ITG09_07880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG09_07895	COG0840	transmembrane signaling receptor activity
ITG09_07910	COG3469	chitinase activity
ITG09_07920	COG4771	TonB-dependent receptor
ITG09_07925	COG2226	methyltransferase
ITG09_07930	COG2199	diguanylate cyclase activity
ITG09_07935	COG0454	-acetyltransferase
ITG09_07950	COG0420	3'-5' exonuclease activity
ITG09_07955	COG0419	ATPase involved in DNA repair
ITG09_07975	COG3046	protein related to deoxyribodipyrimidine photolyase
ITG09_07980	COG0415	Belongs to the DNA photolyase family
ITG09_07985	COG0589	response to stress
ITG09_08005	COG1120	ATPase activity
ITG09_08010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG09_08020	COG4615	Cyclic peptide transporter
ITG09_08040	COG4774	siderophore transport
ITG09_08060	COG2271	Major facilitator Superfamily
ITG09_08070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG09_08095	COG0494	nUDIX hydrolase
ITG09_08110	COG1187	pseudouridine synthase activity
ITG09_08120	COG0110	maltose O-acetyltransferase activity
ITG09_08130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG09_08140	COG1051	belongs to the nudix hydrolase family
ITG09_08170	COG0346	lactoylglutathione lyase activity
ITG09_08190	COG1619	proteins homologs of microcin C7 resistance protein MccF
ITG09_08210	COG0653	protein targeting
ITG09_08220	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_08255	COG0786	glutamate:sodium symporter activity
ITG09_08270	COG0826	peptidase U32
ITG09_08285	COG1126	abc transporter atp-binding protein
ITG09_08290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG09_08295	COG4215	(ABC) transporter
ITG09_08300	COG4160	amino acid transport
ITG09_08315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ITG09_08345	COG1742	UPF0060 membrane protein
ITG09_08370	COG0583	DNA-binding transcription factor activity
ITG09_08405	COG2204	response regulator
ITG09_08415	COG4175	Glycine betaine
ITG09_08415	COG3448	diguanylate cyclase activity
ITG09_08420	COG4176	ABC-type proline glycine betaine transport system permease component
ITG09_08440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ITG09_08440	COG2885	chlorophyll binding
ITG09_08450	COG1793	dna ligase
ITG09_08455	COG0534	Mate efflux family protein
ITG09_08460	COG0307	riboflavin synthase, alpha
ITG09_08470	COG3001	Fructosamine kinase
ITG09_08480	COG0791	NLP P60 protein
ITG09_08485	COG0840	transmembrane signaling receptor activity
ITG09_08495	COG3148	PFAM DTW domain containing protein
ITG09_08500	COG1940	carbohydrate kinase activity
ITG09_08510	COG0303	'Molybdopterin
ITG09_08515	COG0746	molybdenum cofactor guanylyltransferase activity
ITG09_08520	COG3842	ATPase activity
ITG09_08525	COG4662	Binding-protein-dependent transport system inner membrane component
ITG09_08535	COG2204	response regulator
ITG09_08540	COG4191	Histidine kinase
ITG09_08555	COG0488	(ABC) transporter
ITG09_08560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ITG09_08580	COG3381	protein complex oligomerization
ITG09_08590	COG0243	molybdopterin cofactor binding
ITG09_08590	COG3383	formate dehydrogenase (NAD+) activity
ITG09_08595	COG0437	4 iron, 4 sulfur cluster binding
ITG09_08610	COG0004	ammonium transporteR
ITG09_08615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ITG09_08620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ITG09_08630	COG1177	transmembrane transport
ITG09_08640	COG3842	ATPase activity
ITG09_08660	COG0037	tRNA processing
ITG09_08665	COG0589	response to stress
ITG09_08670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG09_08685	COG2217	Heavy metal translocating P-type atpase
ITG09_08695	COG2010	Cytochrome c
ITG09_08710	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG09_08725	COG2205	protein histidine kinase activity
ITG09_08725	COG0784	Response regulator, receiver
ITG09_08755	COG3120	sequence-specific DNA binding
ITG09_08760	COG1067	ATP-dependent peptidase activity
ITG09_08780	COG0488	(ABC) transporter
ITG09_08790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG09_08790	COG0116	Belongs to the methyltransferase superfamily
ITG09_08800	COG0167	dihydroorotate dehydrogenase activity
ITG09_08805	COG2902	Dehydrogenase
ITG09_08815	COG0308	aminopeptidase N
ITG09_08830	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ITG09_08835	COG1956	GAF domain-containing protein
ITG09_08840	COG1132	(ABC) transporter
ITG09_08845	COG2995	paraquat-inducible protein a
ITG09_08850	COG3008	intermembrane lipid transfer
ITG09_08855	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ITG09_08855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG09_08860	COG2996	Protein conserved in bacteria
ITG09_08875	COG0574	Belongs to the PEP-utilizing enzyme family
ITG09_08875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG09_08880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG09_08885	COG1666	GTP binding
ITG09_08895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG09_08900	COG4597	amino acid ABC transporter
ITG09_08905	COG0765	amino acid transport
ITG09_08910	COG1126	abc transporter atp-binding protein
ITG09_08915	COG0670	Belongs to the BI1 family
ITG09_08920	COG2920	part of a sulfur-relay system
ITG09_08925	COG1254	Belongs to the acylphosphatase family
ITG09_08930	COG0840	transmembrane signaling receptor activity
ITG09_08935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG09_08950	COG2885	chlorophyll binding
ITG09_08965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ITG09_08970	COG0602	queuosine metabolic process
ITG09_08975	COG0561	phosphatase activity
ITG09_09005	COG2828	Protein conserved in bacteria
ITG09_09010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ITG09_09015	COG0372	Belongs to the citrate synthase family
ITG09_09020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ITG09_09030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG09_09060	COG4628	conserved protein (DUF2132)
ITG09_09070	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG09_09075	COG0363	glucosamine-6-phosphate deaminase activity
ITG09_09080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ITG09_09085	COG4565	transcriptional regulatory protein
ITG09_09090	COG3290	protein histidine kinase activity
ITG09_09105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_09120	COG1115	amino acid carrier protein
ITG09_09190	COG1115	amino acid carrier protein
ITG09_09195	COG1280	lysine exporter protein (LysE YggA)
ITG09_09200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ITG09_09290	COG0730	response to heat
ITG09_09305	COG0454	-acetyltransferase
ITG09_09315	COG4977	sequence-specific DNA binding
ITG09_09340	COG0471	metal ion transport
ITG09_09395	COG3033	Beta-eliminating lyase
ITG09_09420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_09440	COG2176	DNA-directed DNA polymerase activity
ITG09_09445	COG0517	IMP dehydrogenase activity
ITG09_09450	COG2186	Transcriptional regulator
ITG09_09455	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_09460	COG2186	Transcriptional regulator
ITG09_09495	COG0840	transmembrane signaling receptor activity
ITG09_09510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_09520	COG3181	Tripartite tricarboxylate transporter family receptor
ITG09_09535	COG2186	Transcriptional regulator
ITG09_09545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG09_09550	COG3639	organic phosphonate transmembrane transporter activity
ITG09_09575	COG1917	Cupin 2, conserved barrel domain protein
ITG09_09580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG09_09585	COG0800	Aldolase
ITG09_09590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_09595	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ITG09_09605	COG0010	Belongs to the arginase family
ITG09_09610	COG1166	arginine decarboxylase activity
ITG09_09615	COG2226	methyltransferase
ITG09_09625	COG1309	transcriptional regulator
ITG09_09630	COG0488	(ABC) transporter
ITG09_09645	COG3097	Belongs to the UPF0267 family
ITG09_09650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ITG09_09655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ITG09_09675	COG4326	sporulation control protein
ITG09_09685	COG1228	amidohydrolase
ITG09_09690	COG0010	Belongs to the arginase family
ITG09_09695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ITG09_09700	COG2986	histidine ammonia-lyase
ITG09_09715	COG0247	lactate metabolic process
ITG09_09715	COG0277	FAD linked oxidase domain protein
ITG09_09750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ITG09_09760	COG1643	Atp-dependent helicase
ITG09_09765	COG0281	malic enzyme
ITG09_09770	COG2949	membrane
ITG09_09775	COG0471	metal ion transport
ITG09_09800	COG2199	diguanylate cyclase activity
ITG09_09815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG09_09835	COG0492	ferredoxin-NADP+ reductase activity
ITG09_09840	COG4988	ABC transporter
ITG09_09845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ITG09_09850	COG0840	transmembrane signaling receptor activity
ITG09_09855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG09_09860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG09_09885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ITG09_09900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG09_09905	COG3108	Peptidase M15
ITG09_09910	COG2989	Protein conserved in bacteria
ITG09_09935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG09_09945	COG4235	cytochrome complex assembly
ITG09_09945	COG3088	subunit of a heme lyase
ITG09_09955	COG1138	Cytochrome C-type biogenesis protein
ITG09_09960	COG3301	Polysulphide reductase, NrfD
ITG09_09965	COG0437	4 iron, 4 sulfur cluster binding
ITG09_09975	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ITG09_09995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG09_10000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG09_10005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG09_10020	COG3381	protein complex oligomerization
ITG09_10025	COG0243	molybdopterin cofactor binding
ITG09_10030	COG0437	4 iron, 4 sulfur cluster binding
ITG09_10035	COG3302	dmso reductase anchor subunit
ITG09_10040	COG1546	Belongs to the CinA family
ITG09_10040	COG1058	Belongs to the CinA family
ITG09_10055	COG0019	diaminopimelate decarboxylase activity
ITG09_10095	COG0322	excinuclease ABC activity
ITG09_10100	COG2197	response regulator
ITG09_10105	COG0417	DNA replication proofreading
ITG09_10115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG09_10130	COG1187	pseudouridine synthase activity
ITG09_10135	COG0009	L-threonylcarbamoyladenylate synthase
ITG09_10140	COG0613	PHP domain protein
ITG09_10150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG09_10155	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG09_10160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ITG09_10165	COG0134	indole-3-glycerol-phosphate synthase activity
ITG09_10165	COG0135	phosphoribosylanthranilate isomerase activity
ITG09_10170	COG0133	tryptophan synthase activity
ITG09_10175	COG0159	tryptophan synthase activity
ITG09_10185	COG1301	dicarboxylic acid transport
ITG09_10215	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG09_10235	COG0583	DNA-binding transcription factor activity
ITG09_10245	COG2917	probably involved in intracellular septation
ITG09_10250	COG1607	acyl-coa hydrolase
ITG09_10255	COG2350	Protein conserved in bacteria
ITG09_10265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITG09_10270	COG0583	DNA-binding transcription factor activity
ITG09_10285	COG1032	radical SAM domain protein
ITG09_10290	COG1396	sequence-specific DNA binding
ITG09_10295	COG3135	benzoate transporter
ITG09_10310	COG0463	Glycosyl transferase, family 2
ITG09_10315	COG0745	RESPONSE REGULATOR receiver
ITG09_10335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG09_10340	COG0583	DNA-binding transcription factor activity
ITG09_10385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG09_10405	COG1349	DNA-binding transcription factor activity
ITG09_10410	COG0786	glutamate:sodium symporter activity
ITG09_10425	COG5002	protein histidine kinase activity
ITG09_10425	COG0784	Response regulator, receiver
ITG09_10440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ITG09_10445	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ITG09_10450	COG2885	chlorophyll binding
ITG09_10455	COG0823	Involved in the tonB-independent uptake of proteins
ITG09_10470	COG0811	peptide transport
ITG09_10475	COG0824	Thioesterase
ITG09_10485	COG4890	Cyd operon protein YbgT
ITG09_10490	COG1294	oxidase, subunit
ITG09_10495	COG1271	oxidase subunit
ITG09_10500	COG2255	four-way junction helicase activity
ITG09_10505	COG0632	four-way junction helicase activity
ITG09_10510	COG5278	phosphoserine phosphatase activity
ITG09_10510	COG0840	transmembrane signaling receptor activity
ITG09_10515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ITG09_10520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ITG09_10525	COG1801	Protein of unknown function DUF72
ITG09_10530	COG4106	trans-aconitate 2-methyltransferase activity
ITG09_10535	COG0500	methyltransferase
ITG09_10540	COG0189	ligase activity
ITG09_10540	COG4067	protein conserved in archaea
ITG09_10555	COG3383	formate dehydrogenase (NAD+) activity
ITG09_10560	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ITG09_10565	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ITG09_10570	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ITG09_10575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG09_10580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG09_10585	COG0745	RESPONSE REGULATOR receiver
ITG09_10590	COG3381	protein complex oligomerization
ITG09_10595	COG1609	Transcriptional regulator
ITG09_10600	COG3070	regulator of competence-specific genes
ITG09_10620	COG0297	glycogen (starch) synthase activity
ITG09_10625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG09_10630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG09_10640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ITG09_10650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ITG09_10655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ITG09_10660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ITG09_10670	COG0542	response to heat
ITG09_10675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ITG09_10680	COG1278	Cold shock
ITG09_10690	COG1187	pseudouridine synthase activity
ITG09_10695	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG09_10700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG09_10705	COG1199	ATP-dependent helicase activity
ITG09_10725	COG2850	peptidyl-arginine hydroxylation
ITG09_10730	COG0840	transmembrane signaling receptor activity
ITG09_10735	COG2814	Major facilitator Superfamily
ITG09_10740	COG1770	oligopeptidase
ITG09_10745	COG0708	Exodeoxyribonuclease III
ITG09_10755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_10765	COG4160	amino acid transport
ITG09_10795	COG1882	Formate acetyltransferase
ITG09_10805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG09_10810	COG3013	Belongs to the UPF0304 family
ITG09_10820	COG2766	serine protein kinase
ITG09_10825	COG2718	Belongs to the UPF0229 family
ITG09_10830	COG2719	SpoVR family
ITG09_10835	COG0616	signal peptide processing
ITG09_10840	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_10845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG09_10860	COG0835	chemotaxis
ITG09_10860	COG0784	Response regulator, receiver
ITG09_10865	COG1940	carbohydrate kinase activity
ITG09_10870	COG0469	pyruvate kinase activity
ITG09_10875	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG09_10900	COG0084	hydrolase, TatD family'
ITG09_10915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITG09_10920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG09_10945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG09_10950	COG0416	fatty acid biosynthetic process
ITG09_10955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ITG09_10960	COG1399	metal-binding, possibly nucleic acid-binding protein
ITG09_10970	COG0564	pseudouridine synthase activity
ITG09_10975	COG1530	ribonuclease E activity
ITG09_10980	COG0659	secondary active sulfate transmembrane transporter activity
ITG09_10990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ITG09_10995	COG2982	Protein involved in outer membrane biogenesis
ITG09_11000	COG0572	uridine kinase
ITG09_11005	COG0489	protein tyrosine kinase activity
ITG09_11010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG09_11010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG09_11020	COG2186	Transcriptional regulator
ITG09_11025	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG09_11030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG09_11035	COG0653	protein targeting
ITG09_11040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG09_11045	COG3706	GGDEF domain
ITG09_11060	COG3092	negative regulation of chromosome organization
ITG09_11065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG09_11070	COG0857	belongs to the CobB CobQ family
ITG09_11070	COG0280	phosphate acetyltransferase
ITG09_11075	COG0435	Glutathione S-transferase
ITG09_11085	COG0444	Belongs to the ABC transporter superfamily
ITG09_11090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG09_11095	COG0601	transmembrane transport
ITG09_11105	COG0314	molybdopterin synthase activity
ITG09_11110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ITG09_11115	COG0315	cyclic pyranopterin monophosphate synthase activity
ITG09_11120	COG0521	Mo-molybdopterin cofactor biosynthetic process
ITG09_11125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ITG09_11130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ITG09_11135	COG2198	Histidine kinase
ITG09_11140	COG2204	response regulator
ITG09_11145	COG0556	nucleotide-excision repair
ITG09_11155	COG4657	Part of a membrane complex involved in electron transport
ITG09_11160	COG2878	Part of a membrane complex involved in electron transport
ITG09_11165	COG4656	Part of a membrane complex involved in electron transport
ITG09_11170	COG4658	electron transport chain
ITG09_11175	COG4659	FMN binding
ITG09_11180	COG4660	Part of a membrane complex involved in electron transport
ITG09_11185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ITG09_11190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ITG09_11195	COG0346	lactoylglutathione lyase activity
ITG09_11215	COG2056	Na+-H+ antiporter family
ITG09_11225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ITG09_11245	COG1454	alcohol dehydrogenase
ITG09_11245	COG1012	belongs to the aldehyde dehydrogenase family
ITG09_11250	COG2095	MarC family integral membrane protein
ITG09_11255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG09_11260	COG2165	general secretion pathway protein
ITG09_11265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG09_11270	COG1757	Na H antiporter
ITG09_11285	COG3081	Nucleoid-associated protein
ITG09_11290	COG3082	Protein of unknown function (DUF1414)
ITG09_11325	COG0582	viral genome integration into host DNA
ITG09_11345	COG4372	Transposase
ITG09_11375	COG2274	protein secretion by the type I secretion system
ITG09_11455	COG0840	transmembrane signaling receptor activity
ITG09_11460	COG0123	including yeast histone deacetylase and acetoin utilization protein
ITG09_11475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG09_11480	COG0778	Nitroreductase
ITG09_11485	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG09_11485	COG1902	pentaerythritol trinitrate reductase activity
ITG09_11490	COG0616	signal peptide processing
ITG09_11495	COG0252	asparaginase activity
ITG09_11500	COG3139	Protein of unknown function (DUF1315)
ITG09_11510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG09_11515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG09_11530	COG2226	methyltransferase
ITG09_11550	COG2983	Belongs to the UPF0260 family
ITG09_11565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ITG09_11570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ITG09_11575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ITG09_11580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ITG09_11585	COG2832	Protein of unknown function (DUF454)
ITG09_11595	COG0745	RESPONSE REGULATOR receiver
ITG09_11600	COG0583	DNA-binding transcription factor activity
ITG09_11605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ITG09_11610	COG1286	toxin biosynthetic process
ITG09_11615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ITG09_11620	COG0285	dihydrofolate synthase activity
ITG09_11625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ITG09_11630	COG0101	tRNA pseudouridine synthase activity
ITG09_11640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG09_11645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG09_11650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITG09_11670	COG3101	peptidyl-lysine hydroxylation
ITG09_11675	COG2860	membrane
ITG09_11680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ITG09_11700	COG0515	serine threonine protein kinase
ITG09_11700	COG2815	serine threonine protein kinase
ITG09_11710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ITG09_11720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG09_11725	COG0583	DNA-binding transcription factor activity
ITG09_11730	COG2951	lytic endotransglycosylase activity
ITG09_11735	COG3100	YcgL domain-containing protein
ITG09_11740	COG0850	regulation of cytokinetic process
ITG09_11745	COG2894	cell division
ITG09_11750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ITG09_11755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ITG09_11760	COG0318	PFAM AMP-dependent synthetase and ligase
ITG09_11765	COG0596	Alpha beta hydrolase
ITG09_11780	COG1214	PFAM Peptidase M22, glycoprotease
ITG09_11785	COG1199	ATP-dependent helicase activity
ITG09_11795	COG0788	formyltetrahydrofolate deformylase activity
ITG09_11800	COG3102	Protein conserved in bacteria
ITG09_11805	COG0018	arginyl-trna synthetase
ITG09_11825	COG1918	ferrous iron import across plasma membrane
ITG09_11840	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ITG09_11845	COG1121	(ABC) transporter
ITG09_11850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG09_11860	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG09_11865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG09_11870	COG0567	Dehydrogenase, E1 component
ITG09_11875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG09_11880	COG1053	succinate dehydrogenase
ITG09_11885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ITG09_11900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ITG09_11910	COG0033	Phosphoglucomutase
ITG09_11915	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ITG09_11920	COG0596	Alpha beta hydrolase
ITG09_11945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ITG09_11950	COG1263	PTS System
ITG09_11950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG09_11950	COG2190	(PTS) system
ITG09_11955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITG09_11960	COG1846	Transcriptional regulator
ITG09_11960	COG1940	carbohydrate kinase activity
ITG09_11965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG09_11965	COG4651	solute:proton antiporter activity
ITG09_11970	COG0367	asparagine synthase
ITG09_11980	COG3104	oligopeptide transport
ITG09_11985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ITG09_11990	COG0563	adenylate kinase activity
ITG09_11995	COG0326	Molecular chaperone. Has ATPase activity
ITG09_12000	COG3710	Transcriptional regulator
ITG09_12015	COG0622	Phosphoesterase
ITG09_12040	COG1090	epimerase
ITG09_12045	COG0300	oxidoreductase activity
ITG09_12050	COG3118	belongs to the thioredoxin family
ITG09_12055	COG0330	HflC and HflK could
ITG09_12065	COG0789	Transcriptional regulator
ITG09_12080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ITG09_12085	COG3115	cell septum assembly
ITG09_12090	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ITG09_12100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_12110	COG2190	(PTS) system
ITG09_12115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG09_12120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG09_12125	COG2837	iron assimilation
ITG09_12150	COG1393	Belongs to the ArsC family
ITG09_12155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG09_12170	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ITG09_12175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITG09_12180	COG2716	regulation of RNA biosynthetic process
ITG09_12185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG09_12200	COG4783	chaperone-mediated protein folding
ITG09_12205	COG1393	Belongs to the ArsC family
ITG09_12225	COG2233	PERMEase
ITG09_12240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ITG09_12245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ITG09_12250	COG0121	glutamine amidotransferase
ITG09_12255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG09_12260	COG1960	acyl-CoA dehydrogenase activity
ITG09_12270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITG09_12275	COG0328	RNA-DNA hybrid ribonuclease activity
ITG09_12280	COG2226	methyltransferase
ITG09_12285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG09_12290	COG1388	LysM domain
ITG09_12290	COG0741	lytic transglycosylase activity
ITG09_12300	COG3021	interspecies interaction between organisms
ITG09_12305	COG0347	Belongs to the P(II) protein family
ITG09_12315	COG0037	tRNA processing
ITG09_12320	COG0825	malonyl-CoA metabolic process
ITG09_12325	COG0587	DNA-directed DNA polymerase activity
ITG09_12330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ITG09_12340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG09_12345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITG09_12350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG09_12355	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ITG09_12365	COG0750	zinc metalloprotease
ITG09_12375	COG0575	Belongs to the CDS family
ITG09_12380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ITG09_12385	COG0233	cytoplasmic translational termination
ITG09_12390	COG0528	UMP kinase activity
ITG09_12395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ITG09_12400	COG0052	Belongs to the universal ribosomal protein uS2 family
ITG09_12405	COG0024	Methionine aminopeptidase
ITG09_12410	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ITG09_12420	COG0564	pseudouridine synthase activity
ITG09_12425	COG3098	single-species biofilm formation
ITG09_12450	COG1671	Belongs to the UPF0178 family
ITG09_12460	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG09_12470	COG0254	rRNA binding
ITG09_12475	COG1720	tRNA m6t6A37 methyltransferase activity
ITG09_12480	COG0442	prolyl-tRNA aminoacylation
ITG09_12515	COG0366	Alpha amylase catalytic
ITG09_12520	COG1263	PTS System
ITG09_12520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG09_12525	COG1609	Transcriptional regulator
ITG09_12535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG09_12540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ITG09_12545	COG2011	ABC-type metal ion transport system permease component
ITG09_12550	COG1464	Belongs to the NlpA lipoprotein family
ITG09_12555	COG4580	involved in the transport of maltose and maltodextrins
ITG09_12560	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ITG09_12570	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG09_12570	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG09_12585	COG1611	Belongs to the LOG family
ITG09_12590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG09_12595	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ITG09_12610	COG0583	DNA-binding transcription factor activity
ITG09_12615	COG0301	tRNA thio-modification
ITG09_12615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG09_12625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG09_12630	COG1722	exodeoxyribonuclease VII activity
ITG09_12635	COG0142	geranyltranstransferase activity
ITG09_12640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ITG09_12645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITG09_12650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ITG09_12655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG09_12675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG09_12675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG09_12680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ITG09_12685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ITG09_12700	COG1073	alpha beta
ITG09_12705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ITG09_12710	COG2252	PERMEase
ITG09_12715	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG09_12735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG09_12750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG09_12755	COG1609	Transcriptional regulator
ITG09_12760	COG2017	converts alpha-aldose to the beta-anomer
ITG09_12770	COG1085	galactose-1-phosphate uridylyltransferase
ITG09_12775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG09_12780	COG1609	Transcriptional regulator
ITG09_12785	COG3250	beta-galactosidase activity
ITG09_12790	COG2731	YhcH YjgK YiaL family protein
ITG09_12795	COG0531	amino acid
ITG09_12800	COG0531	amino acid
ITG09_12805	COG3250	beta-galactosidase activity
ITG09_12815	COG0395	ABC-type sugar transport system, permease component
ITG09_12820	COG1175	transmembrane transport
ITG09_12830	COG0534	Mate efflux family protein
ITG09_12835	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_12845	COG1609	Transcriptional regulator
ITG09_12850	COG0583	DNA-binding transcription factor activity
ITG09_12855	COG2059	Chromate
ITG09_12900	COG0455	bacterial-type flagellum organization
ITG09_12910	COG4964	Belongs to the GSP D family
ITG09_12930	COG0583	DNA-binding transcription factor activity
ITG09_12945	COG1022	Amp-dependent synthetase and ligase
ITG09_12955	COG0583	DNA-binding transcription factor activity
ITG09_12960	COG4628	conserved protein (DUF2132)
ITG09_12990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG09_12995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ITG09_13005	COG0560	Phosphoserine phosphatase
ITG09_13015	COG0813	purine-nucleoside phosphorylase activity
ITG09_13025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ITG09_13030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ITG09_13035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG09_13040	COG0084	hydrolase, TatD family'
ITG09_13050	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ITG09_13065	COG3153	acetyltransferase
ITG09_13070	COG3154	lipid carrier protein
ITG09_13080	COG0826	peptidase U32
ITG09_13085	COG0826	peptidase U32
ITG09_13090	COG0534	Mate efflux family protein
ITG09_13105	COG1185	polyribonucleotide nucleotidyltransferase activity
ITG09_13110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ITG09_13115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ITG09_13120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ITG09_13125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ITG09_13130	COG0195	Participates in both transcription termination and antitermination
ITG09_13135	COG0779	Required for maturation of 30S ribosomal subunits
ITG09_13150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG09_13155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG09_13160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ITG09_13165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITG09_13170	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ITG09_13175	COG1534	Rna-binding protein
ITG09_13180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG09_13185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG09_13190	COG2027	D-alanyl-D-alanine carboxypeptidase
ITG09_13195	COG2239	Acts as a magnesium transporter
ITG09_13200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG09_13205	COG0739	heme binding
ITG09_13220	COG0316	Belongs to the HesB IscA family
ITG09_13225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ITG09_13230	COG0628	permease
ITG09_13235	COG2813	Specifically methylates the guanine in position
ITG09_13240	COG0784	Response regulator, receiver
ITG09_13240	COG2205	protein histidine kinase activity
ITG09_13245	COG0747	negative chemotaxis
ITG09_13255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG09_13260	COG0444	Belongs to the ABC transporter superfamily
ITG09_13265	COG4608	Belongs to the ABC transporter superfamily
ITG09_13275	COG2971	BadF BadG BcrA BcrD
ITG09_13290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG09_13295	COG3842	ATPase activity
ITG09_13305	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG09_13310	COG0004	ammonium transporteR
ITG09_13325	COG1049	propionate catabolic process, 2-methylcitrate cycle
ITG09_13330	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITG09_13335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG09_13340	COG1643	Atp-dependent helicase
ITG09_13345	COG1489	DNA binding
ITG09_13365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG09_13370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ITG09_13375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ITG09_13380	COG0842	Transport permease protein
ITG09_13385	COG1131	(ABC) transporter
ITG09_13390	COG0659	secondary active sulfate transmembrane transporter activity
ITG09_13395	COG0288	reversible hydration of carbon dioxide
ITG09_13410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG09_13415	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG09_13420	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ITG09_13425	COG2186	Transcriptional regulator
ITG09_13435	COG0157	Belongs to the NadC ModD family
ITG09_13450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG09_13455	COG1459	type II secretion system
ITG09_13465	COG0237	dephospho-CoA kinase activity
ITG09_13470	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ITG09_13480	COG0335	large ribosomal subunit rRNA binding
ITG09_13485	COG0336	Belongs to the RNA methyltransferase TrmD family
ITG09_13490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ITG09_13495	COG0228	four-way junction DNA binding
ITG09_13500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ITG09_13505	COG4137	Cytochrome C assembly protein
ITG09_13510	COG4536	flavin adenine dinucleotide binding
ITG09_13515	COG1854	S-ribosylhomocysteine lyase activity
ITG09_13525	COG2918	glutathione biosynthetic process
ITG09_13530	COG0612	Peptidase, M16
ITG09_13535	COG1238	metal cluster binding
ITG09_13545	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ITG09_13550	COG0511	ligase activity, forming carbon-carbon bonds
ITG09_13550	COG5016	pyruvate
ITG09_13555	COG3630	sodium ion export across plasma membrane
ITG09_13615	COG0527	aspartate kinase activity
ITG09_13625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG09_13630	COG1546	Belongs to the CinA family
ITG09_13635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ITG09_13640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ITG09_13650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ITG09_13655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ITG09_13660	COG0585	pseudouridine synthase activity
ITG09_13670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ITG09_13675	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ITG09_13680	COG0148	phosphopyruvate hydratase activity
ITG09_13685	COG0504	CTP synthase activity
ITG09_13690	COG3956	TIGRFAM MazG family protein
ITG09_13695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG09_13700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG09_13705	COG2205	protein histidine kinase activity
ITG09_13705	COG3437	response regulator, receiver
ITG09_13705	COG3850	Histidine kinase
ITG09_13705	COG4999	Histidine kinase
ITG09_13710	COG0736	holo-[acyl-carrier-protein] synthase activity
ITG09_13715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ITG09_13720	COG1381	Involved in DNA repair and RecF pathway recombination
ITG09_13725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ITG09_13730	COG0571	ribonuclease III activity
ITG09_13740	COG0481	GTPase activity
ITG09_13760	COG1595	DNA-templated transcription, initiation
ITG09_13765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ITG09_13775	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ITG09_13780	COG0354	folic acid binding
ITG09_13795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG09_13800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG09_13805	COG3079	Belongs to the UPF0149 family
ITG09_13810	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ITG09_13820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ITG09_13825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ITG09_13830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG09_13845	COG1279	arginine transmembrane transporter activity
ITG09_13850	COG0668	transmembrane transport
ITG09_13855	COG0191	fructose-bisphosphate aldolase activity
ITG09_13870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG09_13875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ITG09_13885	COG3091	SprT-like family
ITG09_13890	COG2356	endonuclease I
ITG09_13900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ITG09_13905	COG0189	ligase activity
ITG09_13910	COG1678	Uncharacterized ACR, COG1678
ITG09_13915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ITG09_13930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ITG09_13935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITG09_13940	COG0762	integral membrane protein
ITG09_13955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ITG09_13960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITG09_13965	COG2066	Belongs to the glutaminase family
ITG09_13980	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ITG09_13985	COG0741	lytic transglycosylase activity
ITG09_14025	COG0840	transmembrane signaling receptor activity
ITG09_14175	COG4974	Belongs to the 'phage' integrase family
ITG09_14195	COG0795	lipopolysaccharide-transporting ATPase activity
ITG09_14200	COG0795	lipopolysaccharide-transporting ATPase activity
ITG09_14205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG09_14210	COG2927	DNA polymerase III (CHI subunit)
ITG09_14215	COG0525	valine-tRNA ligase activity
ITG09_14225	COG0456	acetyltransferase
ITG09_14255	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG09_14260	COG0251	oxidation-reduction process
ITG09_14265	COG0204	Acyl-transferase
ITG09_14270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ITG09_14275	COG5007	Belongs to the BolA IbaG family
ITG09_14285	COG2854	intermembrane phospholipid transfer
ITG09_14290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG09_14295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ITG09_14300	COG1127	ABC transporter
ITG09_14310	COG0517	IMP dehydrogenase activity
ITG09_14310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ITG09_14315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ITG09_14325	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ITG09_14330	COG1137	ATPase activity
ITG09_14340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG09_14345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_14350	COG1660	Displays ATPase and GTPase activities
ITG09_14355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_14360	COG2239	Acts as a magnesium transporter
ITG09_14365	COG0312	modulator of DNA gyrase
ITG09_14370	COG3028	Belongs to the UPF0307 family
ITG09_14375	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ITG09_14380	COG1178	ABC-type Fe3 transport system permease component
ITG09_14385	COG4143	(ABC) transporter
ITG09_14390	COG0163	prenyltransferase activity
ITG09_14395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG09_14400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ITG09_14405	COG2105	PFAM AIG2 family protein
ITG09_14410	COG2911	Protein conserved in bacteria
ITG09_14415	COG0729	surface antigen
ITG09_14420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG09_14430	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ITG09_14465	COG0529	Catalyzes the synthesis of activated sulfate
ITG09_14470	COG0471	metal ion transport
ITG09_14470	COG3273	potassium ion transport
ITG09_14475	COG2895	sulfate adenylyltransferase (ATP) activity
ITG09_14480	COG0175	sulfate reduction
ITG09_14530	COG2153	protein acetylation
ITG09_14540	COG3061	Opacity-associated protein A
ITG09_14540	COG3266	domain, Protein
ITG09_14545	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG09_14560	COG0203	ribosomal protein L17
ITG09_14565	COG0202	RNA polymerase activity
ITG09_14570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ITG09_14575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ITG09_14580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ITG09_14585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ITG09_14590	COG0201	protein transport
ITG09_14595	COG0200	Binds to the 23S rRNA
ITG09_14600	COG1841	ribosomal large subunit assembly
ITG09_14605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ITG09_14610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ITG09_14615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ITG09_14620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ITG09_14625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ITG09_14630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ITG09_14635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ITG09_14640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ITG09_14645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ITG09_14655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ITG09_14660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ITG09_14670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ITG09_14675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ITG09_14680	COG0089	rRNA binding
ITG09_14685	COG0088	Forms part of the polypeptide exit tunnel
ITG09_14690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ITG09_14705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG09_14725	COG2923	Belongs to the DsrF TusC family
ITG09_14730	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ITG09_14735	COG2964	Protein conserved in bacteria
ITG09_14740	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG09_14750	COG2900	Belongs to the SlyX family
ITG09_14755	COG1446	asparaginase
ITG09_14760	COG1047	Peptidyl-prolyl cis-trans
ITG09_14775	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG09_14780	COG0488	(ABC) transporter
ITG09_14790	COG0429	hydrolase of the alpha beta-hydrolase fold
ITG09_14795	COG3089	Belongs to the UPF0270 family
ITG09_14800	COG3954	Phosphoribulokinase
ITG09_14805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG09_14815	COG1012	belongs to the aldehyde dehydrogenase family
ITG09_14825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ITG09_14830	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG09_14835	COG2356	endonuclease I
ITG09_14855	COG0180	Tryptophanyl-tRNA synthetase
ITG09_14860	COG0546	phosphoglycolate phosphatase activity
ITG09_14865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG09_14870	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITG09_14880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ITG09_14915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ITG09_14925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG09_14925	COG0678	peroxiredoxin activity
ITG09_14930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG09_14935	COG0251	oxidation-reduction process
ITG09_14945	COG0165	Argininosuccinate lyase
ITG09_14945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG09_14960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ITG09_14965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG09_14970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ITG09_14980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG09_14985	COG0460	homoserine dehydrogenase
ITG09_14985	COG0527	aspartate kinase activity
ITG09_14990	COG0626	cystathionine gamma-synthase activity
ITG09_14995	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ITG09_15000	COG0281	malic enzyme
ITG09_15005	COG0254	rRNA binding
ITG09_15010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITG09_15015	COG1609	Transcriptional regulator
ITG09_15025	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ITG09_15030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ITG09_15035	COG1575	Belongs to the MenA family. Type 1 subfamily
ITG09_15040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG09_15045	COG3074	FtsZ-dependent cytokinesis
ITG09_15050	COG1494	fructose-1,6-bisphosphatase
ITG09_15065	COG3152	Membrane
ITG09_15075	COG0149	triose-phosphate isomerase activity
ITG09_15080	COG0205	6-phosphofructokinase activity
ITG09_15085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITG09_15095	COG0745	RESPONSE REGULATOR receiver
ITG09_15100	COG2205	protein histidine kinase activity
ITG09_15170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITG09_15175	COG1737	Transcriptional regulator
ITG09_15180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITG09_15185	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ITG09_15195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_15200	COG2731	YhcH YjgK YiaL family protein
ITG09_15205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG09_15210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITG09_15215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITG09_15225	COG1027	Aspartate ammonia-lyase
ITG09_15230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG09_15235	COG1288	antiporter activity
ITG09_15245	COG0549	Belongs to the carbamate kinase family
ITG09_15250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ITG09_15255	COG0540	Belongs to the ATCase OTCase family
ITG09_15260	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG09_15265	COG1438	arginine binding
ITG09_15270	COG4232	protein-disulfide reductase activity
ITG09_15280	COG3263	regulation of cellular component size
ITG09_15290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_15305	COG2198	Histidine kinase
ITG09_15305	COG2205	protein histidine kinase activity
ITG09_15305	COG0784	Response regulator, receiver
ITG09_15310	COG2814	Major facilitator Superfamily
ITG09_15325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG09_15330	COG3385	transposase activity
ITG09_15335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ITG09_15340	COG0511	ligase activity, forming carbon-carbon bonds
ITG09_15345	COG0439	Biotin carboxylase
ITG09_15350	COG2264	protein methyltransferase activity
ITG09_15355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG09_15360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG09_15365	COG0789	Transcriptional regulator
ITG09_15370	COG0138	bifunctional purine biosynthesis protein purh
ITG09_15375	COG0151	Belongs to the GarS family
ITG09_15390	COG1253	flavin adenine dinucleotide binding
ITG09_15395	COG3068	Protein conserved in bacteria
ITG09_15405	COG1573	uracil-dna glycosylase
ITG09_15415	COG2816	NAD+ diphosphatase activity
ITG09_15420	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ITG09_15435	COG0222	ribosome binding
ITG09_15440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ITG09_15445	COG0081	regulation of translation
ITG09_15455	COG0250	Participates in transcription elongation, termination and antitermination
ITG09_15460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG09_15490	COG1072	(Pantothenic acid kinase))
ITG09_15500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ITG09_15510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG09_15600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ITG09_15610	COG4206	TonB-dependent receptor
ITG09_15615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG09_15630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG09_15635	COG0534	Mate efflux family protein
ITG09_15640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ITG09_15645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ITG09_15650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG09_15655	COG2937	Belongs to the GPAT DAPAT family
ITG09_15660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ITG09_15665	COG3161	chorismate lyase activity
ITG09_15670	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG09_15675	COG0705	Rhomboid family
ITG09_15680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG09_15690	COG2177	Part of the ABC transporter FtsEX involved in
ITG09_15695	COG2884	Cell division ATP-binding protein ftsE
ITG09_15700	COG0552	protein localization to endoplasmic reticulum
ITG09_15700	COG0552	protein localization to endoplasmic reticulum
ITG09_15705	COG0742	ribosomal rna small subunit methyltransferase
ITG09_15715	COG3385	transposase activity
ITG09_15720	COG2095	MarC family integral membrane protein
ITG09_15760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG09_15765	COG0640	Transcriptional regulator
ITG09_15770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG09_15775	COG1280	lysine exporter protein (LysE YggA)
ITG09_15780	COG2267	carboxylic ester hydrolase activity
ITG09_15785	COG0561	phosphatase activity
ITG09_15800	COG3148	PFAM DTW domain containing protein
ITG09_15805	COG2199	diguanylate cyclase activity
ITG09_15805	COG2200	EAL domain
ITG09_15805	COG3287	FIST C domain
ITG09_15810	COG2200	EAL domain
ITG09_15810	COG3287	FIST C domain
ITG09_15810	COG2199	diguanylate cyclase activity
ITG09_15815	COG1011	Hydrolase
ITG09_15820	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ITG09_15830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ITG09_15835	COG0019	diaminopimelate decarboxylase activity
ITG09_15845	COG1965	Belongs to the frataxin family
ITG09_15850	COG3072	Adenylate cyclase
ITG09_15855	COG0181	hydroxymethylbilane synthase activity
ITG09_15860	COG1587	Uroporphyrinogen-III synthase
ITG09_15865	COG2959	enzyme of heme biosynthesis
ITG09_15870	COG3071	HemY protein
ITG09_15945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG09_15970	COG0745	RESPONSE REGULATOR receiver
ITG09_15975	COG0642	Histidine kinase
ITG09_15995	COG0513	Belongs to the DEAD box helicase family
ITG09_16010	COG3706	GGDEF domain
ITG09_16015	COG1278	Cold shock
ITG09_16020	COG0402	S-adenosylhomocysteine deaminase activity
ITG09_16025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITG09_16045	COG4413	Urea transporter
ITG09_16060	COG0531	amino acid
ITG09_16075	COG1280	lysine exporter protein (LysE YggA)
ITG09_16090	COG1151	hydroxylamine reductase activity
ITG09_16095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG09_16120	COG2926	Belongs to the UPF0265 family
ITG09_16130	COG3132	Protein of unknown function, DUF480
ITG09_16135	COG2827	Endonuclease containing a URI domain
ITG09_16165	COG0443	Heat shock 70 kDa protein
ITG09_16175	COG0179	Fumarylacetoacetate (FAA) hydrolase
ITG09_16180	COG1280	lysine exporter protein (LysE YggA)
ITG09_16185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG09_16195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG09_16205	COG1845	cytochrome c oxidase, subunit III
ITG09_16225	COG1612	heme a metabolic process
ITG09_16230	COG0109	protoheme IX farnesyltransferase activity
ITG09_16250	COG3530	Putative quorum-sensing-regulated virulence factor
ITG09_16255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG09_16265	COG0662	Cupin 2, conserved barrel domain protein
ITG09_16265	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ITG09_16270	COG0668	transmembrane transport
ITG09_16275	COG0569	domain protein
ITG09_16280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG09_16285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG09_16285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG09_16290	COG1765	OsmC-like protein
ITG09_16295	COG2885	chlorophyll binding
ITG09_16305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG09_16315	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG09_16320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG09_16325	COG3842	ATPase activity
ITG09_16345	COG2375	cellular response to nickel ion
ITG09_16350	COG3104	oligopeptide transport
ITG09_16355	COG1760	l-serine dehydratase
ITG09_16375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG09_16380	COG1132	(ABC) transporter
ITG09_16385	COG1132	(ABC) transporter
ITG09_16410	COG0739	heme binding
ITG09_16415	COG0393	Putative heavy-metal-binding
ITG09_16435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITG09_16455	COG0346	lactoylglutathione lyase activity
ITG09_16470	COG2200	EAL domain
ITG09_16475	COG0156	8-amino-7-oxononanoate synthase activity
ITG09_16480	COG1063	alcohol dehydrogenase
ITG09_16500	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG09_16535	COG1454	alcohol dehydrogenase
ITG09_16540	COG1011	Hydrolase
ITG09_16570	COG1328	CTP reductase activity
ITG09_16575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG09_16580	COG0583	DNA-binding transcription factor activity
ITG09_16600	COG1289	transmembrane transporter activity
ITG09_16605	COG0210	DNA helicase
ITG09_16615	COG1803	Methylglyoxal synthase
ITG09_16620	COG1879	ABC-type sugar transport system periplasmic component
ITG09_16625	COG5002	protein histidine kinase activity
ITG09_16625	COG0784	Response regulator, receiver
ITG09_16625	COG2198	Histidine kinase
ITG09_16675	COG0625	glutathione transferase activity
ITG09_16680	COG3064	Membrane
ITG09_16695	COG2205	protein histidine kinase activity
ITG09_16700	COG0745	RESPONSE REGULATOR receiver
ITG09_16735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_16735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_16735	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ITG09_16740	COG1105	Belongs to the carbohydrate kinase PfkB family
ITG09_16745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_16745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_16750	COG1609	Transcriptional regulator
ITG09_16755	COG0515	serine threonine protein kinase
ITG09_16755	COG2815	serine threonine protein kinase
ITG09_16760	COG2223	nitrite transmembrane transporter activity
ITG09_16770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG09_16775	COG0243	molybdopterin cofactor binding
ITG09_16805	COG2026	Addiction module toxin, RelE StbE family
ITG09_16860	COG1609	Transcriptional regulator
ITG09_16865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG09_16870	COG1879	ABC-type sugar transport system periplasmic component
ITG09_16875	COG1172	Belongs to the binding-protein-dependent transport system permease family
ITG09_16880	COG1129	ABC transporter
ITG09_16885	COG1869	D-ribose catabolic process
ITG09_16905	COG4166	transmembrane transport
ITG09_16910	COG4174	ABC transporter (Permease)
ITG09_16915	COG4239	(ABC) transporter, permease
ITG09_16920	COG4172	Belongs to the ABC transporter superfamily
ITG09_16930	COG0583	DNA-binding transcription factor activity
ITG09_16940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG09_16950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG09_16960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG09_16975	COG0356	it plays a direct role in the translocation of protons across the membrane
ITG09_16985	COG0583	DNA-binding transcription factor activity
ITG09_16995	COG1012	belongs to the aldehyde dehydrogenase family
ITG09_17005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG09_17045	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG09_17065	COG5001	Diguanylate cyclase
ITG09_17065	COG3300	MHYT domain
ITG09_17075	COG0384	phenazine biosynthesis protein PhzF
ITG09_17100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ITG09_17115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG09_17130	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG09_17150	COG3119	arylsulfatase activity
ITG09_17155	COG3119	arylsulfatase activity
ITG09_17165	COG0714	Associated with various cellular activities
ITG09_17195	COG0583	DNA-binding transcription factor activity
ITG09_17200	COG1597	lipid kinase activity
ITG09_17215	COG0641	radical SAM
ITG09_17225	COG0405	Gamma-glutamyltransferase
ITG09_17240	COG0784	Response regulator, receiver
ITG09_17240	COG2205	protein histidine kinase activity
ITG09_17240	COG5002	protein histidine kinase activity
ITG09_17255	COG1132	(ABC) transporter
ITG09_17260	COG1538	Outer membrane efflux protein
ITG09_17265	COG0784	Response regulator, receiver
ITG09_17265	COG2205	protein histidine kinase activity
ITG09_17270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_17305	COG0840	transmembrane signaling receptor activity
ITG09_17350	COG0745	RESPONSE REGULATOR receiver
ITG09_17355	COG5002	protein histidine kinase activity
ITG09_17360	COG1881	PFAM PEBP family protein
ITG09_17370	COG2807	transmembrane transport
ITG09_17405	COG1280	lysine exporter protein (LysE YggA)
ITG09_17425	COG0534	Mate efflux family protein
ITG09_17445	COG0509	glycine decarboxylation via glycine cleavage system
ITG09_17485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG09_17490	COG3706	GGDEF domain
ITG09_17495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ITG09_17500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG09_17515	COG0784	Response regulator, receiver
ITG09_17515	COG3437	response regulator, receiver
ITG09_17520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG09_17530	COG0814	amino acid
ITG09_17535	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ITG09_17540	COG0513	Belongs to the DEAD box helicase family
ITG09_17565	COG2200	EAL domain
ITG09_17580	COG3038	cytochrome b561
ITG09_17585	COG2353	YceI-like domain
ITG09_17590	COG2116	formate transmembrane transporter activity
ITG09_17595	COG0583	DNA-binding transcription factor activity
ITG09_17605	COG3593	DNA synthesis involved in DNA repair
ITG09_17610	COG0737	Belongs to the 5'-nucleotidase family
ITG09_17615	COG0861	Integral membrane protein TerC family
ITG09_17630	COG0513	Belongs to the DEAD box helicase family
ITG09_17635	COG0729	surface antigen
ITG09_17645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG09_17665	COG1566	PFAM secretion protein HlyD family protein
ITG09_17675	COG2985	domain, Protein
ITG09_17685	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ITG09_17700	COG0583	DNA-binding transcription factor activity
ITG09_17715	COG2267	carboxylic ester hydrolase activity
ITG09_17720	COG2067	long-chain fatty acid transport protein
ITG09_17730	COG0501	Belongs to the peptidase M48B family
ITG09_17735	COG2050	protein possibly involved in aromatic compounds catabolism
ITG09_17745	COG4533	DNA binding
ITG09_17775	COG0768	penicillin binding
ITG09_17785	COG1716	ATPase activity
ITG09_17785	COG5001	Diguanylate cyclase
ITG09_17790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG09_17800	COG4181	ATPase activity
ITG09_17805	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ITG09_17815	COG1984	allophanate hydrolase subunit 2
ITG09_17845	COG3300	MHYT domain
ITG09_17845	COG5001	Diguanylate cyclase
ITG09_17855	COG1629	transport
ITG09_17855	COG4771	TonB-dependent receptor
ITG09_17860	COG0583	DNA-binding transcription factor activity
ITG09_17865	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG09_17865	COG1042	CoA-binding domain protein
ITG09_17865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG09_17870	COG3266	domain, Protein
ITG09_17875	COG1181	Belongs to the D-alanine--D-alanine ligase family
ITG09_17890	COG0023	Translation Initiation Factor
ITG09_17945	COG0210	DNA helicase
ITG09_17975	COG3140	Belongs to the UPF0181 family
ITG09_18000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ITG09_18005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ITG09_18020	COG3706	GGDEF domain
ITG09_18030	COG4251	negative regulation of phosphorylation
ITG09_18030	COG5001	Diguanylate cyclase
ITG09_18030	COG3706	GGDEF domain
ITG09_18030	COG2203	Gaf domain
ITG09_18040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ITG09_18045	COG4149	molybdate abc transporter
ITG09_18050	COG0725	ABC transporter, periplasmic molybdate-binding protein
ITG09_18070	COG0488	(ABC) transporter
ITG09_18075	COG4067	protein conserved in archaea
ITG09_18075	COG0189	ligase activity
ITG09_18085	COG0602	queuosine metabolic process
ITG09_18115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG09_18135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ITG09_18140	COG0732	type I restriction modification DNA specificity domain
ITG09_18145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ITG09_18155	COG0210	DNA helicase
ITG09_18185	COG0602	queuosine metabolic process
ITG09_18190	COG1328	CTP reductase activity
ITG09_18205	COG2391	methyltransferase activity
ITG09_18225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG09_18230	COG3118	belongs to the thioredoxin family
ITG09_18240	COG0318	PFAM AMP-dependent synthetase and ligase
ITG09_18270	COG0534	Mate efflux family protein
ITG09_18295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG09_18295	COG1321	iron dependent repressor
ITG09_18300	COG1121	(ABC) transporter
ITG09_18305	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITG09_18350	COG0848	biopolymer transport protein
ITG09_18355	COG0811	peptide transport
ITG09_18360	COG0811	peptide transport
ITG09_18370	COG4774	siderophore transport
ITG09_18375	COG1301	dicarboxylic acid transport
ITG09_18380	COG2205	protein histidine kinase activity
ITG09_18385	COG0745	RESPONSE REGULATOR receiver
ITG09_18400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITG09_18400	COG1648	precorrin-2 dehydrogenase activity
ITG09_18405	COG2116	formate transmembrane transporter activity
ITG09_18415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG09_18455	COG3712	iron ion homeostasis
ITG09_18490	COG0848	biopolymer transport protein
ITG09_18535	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ITG09_18545	COG0494	nUDIX hydrolase
ITG09_18550	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ITG09_18600	COG3706	GGDEF domain
ITG09_18630	COG1929	Belongs to the glycerate kinase type-1 family
ITG09_18635	COG0383	alpha-mannosidase activity
ITG09_18640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_18640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_18640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_18645	COG2188	Transcriptional regulator
ITG09_18670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG09_18675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_18680	COG2067	long-chain fatty acid transport protein
ITG09_18685	COG2267	carboxylic ester hydrolase activity
ITG09_18700	COG3069	C4-dicarboxylate transmembrane transporter activity
ITG09_18705	COG2197	response regulator
ITG09_18710	COG3850	Histidine kinase
ITG09_18715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG09_18715	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG09_18725	COG0243	molybdopterin cofactor binding
ITG09_18730	COG3043	anaerobic respiration
ITG09_18755	COG0183	Belongs to the thiolase family
ITG09_18800	COG0745	RESPONSE REGULATOR receiver
ITG09_18835	COG0513	Belongs to the DEAD box helicase family
ITG09_18840	COG0523	cobalamin synthesis protein
ITG09_18845	COG0038	chloride channel
ITG09_18855	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ITG09_18865	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ITG09_18870	COG1175	transmembrane transport
ITG09_18880	COG1609	Transcriptional regulator
ITG09_18885	COG1017	nitric oxide dioxygenase activity
ITG09_18885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG09_18890	COG3604	Transcriptional regulator
ITG09_18910	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG09_18915	COG1309	transcriptional regulator
ITG09_18920	COG2130	NADP-dependent
ITG09_18930	COG0564	pseudouridine synthase activity
ITG09_18940	COG1686	Belongs to the peptidase S11 family
ITG09_18955	COG3706	GGDEF domain
ITG09_18965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG09_18975	COG3059	membrane
ITG09_19000	COG0251	oxidation-reduction process
ITG09_19015	COG2207	Transcriptional regulator
ITG09_19020	COG1979	alcohol dehydrogenase
ITG09_19025	COG1126	abc transporter atp-binding protein
ITG09_19030	COG0765	amino acid transport
ITG09_19040	COG0765	amino acid transport
ITG09_19055	COG1280	lysine exporter protein (LysE YggA)
ITG09_19085	COG2824	Alkylphosphonate utilization operon protein PhnA
ITG09_19115	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG09_19120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_19140	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG09_19140	COG1902	pentaerythritol trinitrate reductase activity
ITG09_19150	COG3710	Transcriptional regulator
ITG09_19165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG09_19170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_19180	COG2985	domain, Protein
ITG09_19200	COG1024	Enoyl-CoA hydratase
ITG09_19215	COG4774	siderophore transport
ITG09_19230	COG1120	ATPase activity
ITG09_19240	COG2133	pyrroloquinoline quinone binding
ITG09_19245	COG1278	Cold shock
ITG09_19250	COG4681	YaeQ
ITG09_19260	COG0302	gtp cyclohydrolase
ITG09_19290	COG2897	thiosulfate sulfurtransferase activity
ITG09_19295	COG4251	negative regulation of phosphorylation
ITG09_19295	COG5001	Diguanylate cyclase
ITG09_19295	COG2203	Gaf domain
ITG09_19295	COG3706	GGDEF domain
ITG09_19330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG09_19335	COG0840	transmembrane signaling receptor activity
ITG09_19340	COG1522	sequence-specific DNA binding
ITG09_19360	COG3385	transposase activity
ITG09_19365	COG2814	Major facilitator Superfamily
ITG09_19370	COG0583	DNA-binding transcription factor activity
ITG09_19380	COG3437	response regulator, receiver
ITG09_19385	COG4604	ABC transporter, ATP-binding protein
ITG09_19390	COG4605	iron ion homeostasis
ITG09_19395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG09_19400	COG4607	ABC-type enterochelin transport system periplasmic component
ITG09_19430	COG0628	permease
ITG09_19440	COG1566	PFAM secretion protein HlyD family protein
ITG09_19450	COG3706	GGDEF domain
ITG09_19475	COG0402	S-adenosylhomocysteine deaminase activity
ITG09_19490	COG0583	DNA-binding transcription factor activity
ITG09_19500	COG0352	thiamine-phosphate diphosphorylase activity
ITG09_19505	COG0840	transmembrane signaling receptor activity
ITG09_19510	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ITG09_19515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ITG09_19520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG09_19525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG09_19530	COG1116	anion transmembrane transporter activity
ITG09_19535	COG0351	phosphomethylpyrimidine kinase
ITG09_19540	COG0697	spore germination
ITG09_19570	COG3710	Transcriptional regulator
ITG09_19585	COG2205	protein histidine kinase activity
ITG09_19610	COG0628	permease
ITG09_19635	COG1785	Belongs to the alkaline phosphatase family
ITG09_19645	COG0516	GMP reductase activity
ITG09_19670	COG0534	Mate efflux family protein
ITG09_19675	COG0583	DNA-binding transcription factor activity
ITG09_19680	COG0366	Alpha amylase catalytic
ITG09_19695	COG0697	spore germination
ITG09_19715	COG0604	alcohol dehydrogenase
ITG09_19720	COG0583	DNA-binding transcription factor activity
ITG09_19760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG09_19765	COG0513	Belongs to the DEAD box helicase family
ITG09_19770	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ITG09_19785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITG09_19820	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG09_19830	COG0667	Aldo Keto reductase
ITG09_19835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG09_19840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ITG09_19845	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ITG09_19850	COG0513	Belongs to the DEAD box helicase family
ITG09_19860	COG2176	DNA-directed DNA polymerase activity
ITG09_19875	COG0513	Belongs to the DEAD box helicase family
ITG09_19880	COG4989	oxidoreductase activity
ITG09_19900	COG1538	Outer membrane efflux protein
ITG09_19905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_19950	COG0668	transmembrane transport
ITG09_19960	COG4232	protein-disulfide reductase activity
ITG09_19965	COG3118	belongs to the thioredoxin family
ITG09_19980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG09_19985	COG0697	spore germination
ITG09_20000	COG2814	Major facilitator Superfamily
ITG09_20005	COG0583	DNA-binding transcription factor activity
ITG09_20010	COG5001	Diguanylate cyclase
ITG09_20015	COG0739	heme binding
ITG09_20040	COG3314	Sporulation integral membrane protein YlbJ
ITG09_20050	COG0366	Alpha amylase catalytic
ITG09_20055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG09_20060	COG0784	Response regulator, receiver
ITG09_20060	COG0835	chemotaxis
ITG09_20065	COG2096	Adenosyltransferase
ITG09_20070	COG0748	coenzyme F420 binding
ITG09_20075	COG3721	Heme iron utilization protein
ITG09_20085	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ITG09_20090	COG0811	peptide transport
ITG09_20095	COG0848	biopolymer transport protein
ITG09_20105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG09_20110	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG09_20155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ITG09_20160	COG0633	Ferredoxin
ITG09_20160	COG3217	Mosc domain protein beta barrel domain protein
ITG09_20170	COG0418	dihydroorotase activity
ITG09_20175	COG2354	Protein conserved in bacteria
ITG09_20185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG09_20200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG09_20200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG09_20205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG09_20210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG09_20215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG09_20245	COG0730	response to heat
ITG09_20250	COG0280	phosphate acetyltransferase
ITG09_20255	COG1414	Transcriptional regulator
ITG09_20260	COG1012	belongs to the aldehyde dehydrogenase family
ITG09_20310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG09_20320	COG0583	DNA-binding transcription factor activity
ITG09_20325	COG3961	Belongs to the TPP enzyme family
ITG09_20335	COG1566	PFAM secretion protein HlyD family protein
ITG09_20350	COG1904	glucuronate isomerase
ITG09_20355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_20375	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_20395	COG3706	GGDEF domain
ITG09_20415	COG0583	DNA-binding transcription factor activity
ITG09_20435	COG1136	(ABC) transporter
ITG09_20440	COG0577	efflux transmembrane transporter activity
ITG09_20460	COG3119	arylsulfatase activity
ITG09_20470	COG0641	radical SAM
ITG09_20505	COG3833	ABC-type maltose transport systems, permease component
ITG09_20510	COG1175	transmembrane transport
ITG09_20520	COG3842	ATPase activity
ITG09_20525	COG3385	transposase activity
ITG09_20535	COG0840	transmembrane signaling receptor activity
ITG09_20540	COG0714	Associated with various cellular activities
ITG09_20555	COG2304	oxidoreductase activity
ITG09_20560	COG2304	oxidoreductase activity
ITG09_20575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG09_20580	COG0581	inorganic phosphate transmembrane transporter activity
ITG09_20585	COG0573	inorganic phosphate transmembrane transporter activity
ITG09_20595	COG0840	transmembrane signaling receptor activity
ITG09_20605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITG09_20610	COG3240	lipase activity
ITG09_20615	COG0513	Belongs to the DEAD box helicase family
ITG09_20625	COG1388	LysM domain
ITG09_20625	COG1376	ErfK ybiS ycfS ynhG family protein
ITG09_20630	COG0813	purine-nucleoside phosphorylase activity
ITG09_20660	COG1566	PFAM secretion protein HlyD family protein
ITG09_20665	COG4720	Psort location CytoplasmicMembrane, score
ITG09_20670	COG1122	ATPase activity
ITG09_20685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ITG09_20690	COG1640	4-alpha-glucanotransferase
ITG09_20695	COG0058	SHG alpha-glucan phosphorylase activity
ITG09_20700	COG2909	trisaccharide binding
ITG09_20715	COG1999	signal sequence binding
ITG09_20725	COG1162	GTPase activity
ITG09_20730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ITG09_20740	COG4566	intracellular signal transduction
ITG09_20770	COG3258	Cytochrome c
ITG09_20810	COG4580	involved in the transport of maltose and maltodextrins
ITG09_20830	COG0204	Acyl-transferase
ITG09_20835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG09_20840	COG3615	Tellurite resistance protein tehB
ITG09_20845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG09_20850	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG09_20855	COG0753	catalase activity
ITG09_20860	COG1929	Belongs to the glycerate kinase type-1 family
ITG09_20870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG09_20875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG09_20880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG09_20890	COG0561	phosphatase activity
ITG09_20905	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITG09_20910	COG1414	Transcriptional regulator
ITG09_20915	COG3623	hexulose-6-phosphate isomerase
ITG09_20935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG09_20940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG09_20950	COG3623	hexulose-6-phosphate isomerase
ITG09_20955	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITG09_20960	COG0561	phosphatase activity
ITG09_21025	COG0583	DNA-binding transcription factor activity
ITG09_21040	COG0561	phosphatase activity
ITG09_21065	COG0798	PFAM Bile acid sodium symporter
ITG09_21070	COG0583	DNA-binding transcription factor activity
ITG09_21080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG09_21085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ITG09_21090	COG1349	DNA-binding transcription factor activity
ITG09_21095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ITG09_21100	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_21105	COG0583	DNA-binding transcription factor activity
ITG09_21115	COG1794	racemase activity, acting on amino acids and derivatives
ITG09_21135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG09_21145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITG09_21210	COG4964	Belongs to the GSP D family
ITG09_21245	COG3706	GGDEF domain
ITG09_21250	COG0583	DNA-binding transcription factor activity
ITG09_21255	COG0583	DNA-binding transcription factor activity
ITG09_21260	COG2814	Major facilitator Superfamily
ITG09_21265	COG0110	maltose O-acetyltransferase activity
ITG09_21270	COG1609	Transcriptional regulator
ITG09_21275	COG2723	6-phospho-beta-galactosidase activity
ITG09_21290	COG0346	lactoylglutathione lyase activity
ITG09_21305	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG09_21310	COG0583	DNA-binding transcription factor activity
ITG09_21315	COG0534	Mate efflux family protein
ITG09_21320	COG1024	Enoyl-CoA hydratase
ITG09_21325	COG0300	oxidoreductase activity
ITG09_21335	COG2723	6-phospho-beta-galactosidase activity
ITG09_21340	COG1263	PTS System
ITG09_21340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG09_21345	COG3265	gluconokinase activity
ITG09_21350	COG0129	dihydroxy-acid dehydratase activity
ITG09_21360	COG1609	Transcriptional regulator
ITG09_21440	COG0646	methionine synthase
ITG09_21440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG09_21465	COG0604	alcohol dehydrogenase
ITG09_21465	COG3321	synthase
ITG09_21465	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_21475	COG2814	Major facilitator Superfamily
ITG09_21480	COG2207	Transcriptional regulator
ITG09_21495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG09_21515	COG2207	Transcriptional regulator
ITG09_21535	COG2169	Transcriptional regulator
ITG09_21540	COG1486	melibiose metabolic process
ITG09_21545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG09_21565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITG09_21570	COG1072	(Pantothenic acid kinase))
ITG09_21580	COG1063	alcohol dehydrogenase
ITG09_21585	COG2213	PTS system mannitol-specific
ITG09_21590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_21605	COG1846	Transcriptional regulator
ITG09_21630	COG1012	belongs to the aldehyde dehydrogenase family
ITG09_21635	COG1309	transcriptional regulator
ITG09_21655	COG0745	RESPONSE REGULATOR receiver
ITG09_21660	COG2205	protein histidine kinase activity
ITG09_21680	COG0579	oxidoreductase
ITG09_21695	COG2204	response regulator
ITG09_21700	COG3852	Histidine kinase
ITG09_21710	COG0800	Aldolase
ITG09_21720	COG4145	pantothenate transmembrane transporter activity
ITG09_21730	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ITG09_21760	COG2194	sulfuric ester hydrolase activity
ITG09_21785	COG1132	(ABC) transporter
ITG09_21820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_21845	COG0259	pyridoxamine-phosphate oxidase activity
ITG09_21890	COG1444	tRNA N-acetyltransferase activity
ITG09_21915	COG4608	Belongs to the ABC transporter superfamily
ITG09_21920	COG0444	Belongs to the ABC transporter superfamily
ITG09_21930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG09_21930	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ITG09_21945	COG4221	oxidoreductase activity
ITG09_21960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG09_21975	COG0765	amino acid transport
ITG09_22010	COG3842	ATPase activity
ITG09_22020	COG0745	RESPONSE REGULATOR receiver
ITG09_22025	COG2205	protein histidine kinase activity
ITG09_22045	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ITG09_22055	COG0625	glutathione transferase activity
ITG09_22075	COG3321	synthase
ITG09_22075	COG0604	alcohol dehydrogenase
ITG09_22080	COG0583	DNA-binding transcription factor activity
ITG09_22085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG09_22090	COG3186	Phenylalanine-4-hydroxylase
ITG09_22105	COG0217	transcriptional regulatory protein
ITG09_22120	COG2084	Dehydrogenase
ITG09_22135	COG0583	DNA-binding transcription factor activity
ITG09_22155	COG3842	ATPase activity
ITG09_22160	COG1175	transmembrane transport
ITG09_22165	COG0395	ABC-type sugar transport system, permease component
ITG09_22175	COG0546	phosphoglycolate phosphatase activity
ITG09_22180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ITG09_22200	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG09_22215	COG3275	phosphorelay sensor kinase activity
ITG09_22220	COG3279	Response regulator of the LytR AlgR family
ITG09_22230	COG0612	Peptidase, M16
ITG09_22240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG09_22245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG09_22260	COG1902	pentaerythritol trinitrate reductase activity
ITG09_22265	COG2814	Major facilitator Superfamily
ITG09_22270	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_22285	COG2205	protein histidine kinase activity
ITG09_22290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG09_22290	COG1263	PTS System
ITG09_22305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG09_22315	COG0724	RNA recognition motif
ITG09_22340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG09_22355	COG4221	oxidoreductase activity
ITG09_22365	COG0415	Belongs to the DNA photolyase family
ITG09_22375	COG3806	Anti-sigma factor
ITG09_22380	COG1595	DNA-templated transcription, initiation
ITG09_22390	COG1942	4-Oxalocrotonate Tautomerase
ITG09_22405	COG0786	glutamate:sodium symporter activity
ITG09_22410	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG09_22430	COG2213	PTS system mannitol-specific
ITG09_22430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_22435	COG0246	Mannitol dehydrogenase
ITG09_22440	COG3722	fumarate hydratase activity
ITG09_22445	COG0363	glucosamine-6-phosphate deaminase activity
ITG09_22465	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITG09_22480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ITG09_22490	COG3366	ferrous iron transmembrane transporter activity
ITG09_22495	COG0700	Nucleoside recognition
ITG09_22500	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ITG09_22545	COG0596	Alpha beta hydrolase
ITG09_22560	COG3123	guanosine phosphorylase activity
ITG09_22565	COG1741	Belongs to the pirin family
ITG09_22600	COG0745	RESPONSE REGULATOR receiver
ITG09_22615	COG1054	Belongs to the UPF0176 family
ITG09_22630	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG09_22635	COG0583	DNA-binding transcription factor activity
ITG09_22640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG09_22645	COG2207	Transcriptional regulator
ITG09_22645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG09_22650	COG0534	Mate efflux family protein
ITG09_22660	COG4172	Belongs to the ABC transporter superfamily
ITG09_22665	COG0747	negative chemotaxis
ITG09_22685	COG1304	FMN binding
ITG09_22690	COG1620	l-lactate permease
ITG09_22695	COG0583	DNA-binding transcription factor activity
ITG09_22700	COG1505	serine-type exopeptidase activity
ITG09_22725	COG0395	ABC-type sugar transport system, permease component
ITG09_22730	COG2723	6-phospho-beta-galactosidase activity
ITG09_22735	COG3842	ATPase activity
ITG09_22740	COG3459	Glycosyltransferase 36 associated
ITG09_22745	COG2017	converts alpha-aldose to the beta-anomer
ITG09_22755	COG1609	Transcriptional regulator
ITG09_22770	COG4172	Belongs to the ABC transporter superfamily
ITG09_22780	COG1067	ATP-dependent peptidase activity
ITG09_22825	COG1846	Transcriptional regulator
ITG09_22835	COG0583	DNA-binding transcription factor activity
ITG09_22840	COG2259	Doxx family
ITG09_22850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ITG09_22855	COG3960	tartronate-semialdehyde synthase activity
ITG09_22860	COG3622	Belongs to the hyi family
ITG09_22865	COG2084	Dehydrogenase
ITG09_22880	COG0402	S-adenosylhomocysteine deaminase activity
ITG09_22895	COG2252	PERMEase
ITG09_22915	COG4266	Belongs to the allantoicase family
ITG09_22920	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ITG09_22950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ITG09_22970	COG0789	Transcriptional regulator
ITG09_22975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ITG09_22985	COG0402	S-adenosylhomocysteine deaminase activity
ITG09_22995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ITG09_23020	COG1418	mRNA catabolic process
ITG09_23025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG09_23030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG09_23070	COG0583	DNA-binding transcription factor activity
ITG09_23075	COG0625	glutathione transferase activity
ITG09_23080	COG0583	DNA-binding transcription factor activity
ITG09_23095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG09_23100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ITG09_23105	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ITG09_23130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG09_23135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_23140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG09_23145	COG0577	efflux transmembrane transporter activity
ITG09_23145	COG1136	(ABC) transporter
ITG09_23150	COG2205	protein histidine kinase activity
ITG09_23155	COG0745	RESPONSE REGULATOR receiver
ITG09_23165	COG1882	Formate acetyltransferase
ITG09_23185	COG4303	Ethanolamine ammonia lyase large subunit
ITG09_23195	COG0531	amino acid
ITG09_23205	COG2814	Major facilitator Superfamily
ITG09_23210	COG1609	Transcriptional regulator
ITG09_23215	COG4948	Mandelate Racemase Muconate Lactonizing
ITG09_23230	COG4774	siderophore transport
ITG09_23235	COG0698	ribose 5-phosphate isomerase
ITG09_23245	COG4166	transmembrane transport
ITG09_23250	COG0583	DNA-binding transcription factor activity
ITG09_23275	COG0546	phosphoglycolate phosphatase activity
ITG09_23280	COG3842	ATPase activity
ITG09_23285	COG0765	amino acid transport
ITG09_23295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_23310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG09_23310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_23310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_23315	COG2207	Transcriptional regulator
ITG09_23320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG09_23330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_23335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG09_23355	COG0814	amino acid
ITG09_23360	COG2814	Major facilitator Superfamily
ITG09_23375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG09_23400	COG0583	DNA-binding transcription factor activity
ITG09_23425	COG0583	DNA-binding transcription factor activity
ITG09_23435	COG4948	Mandelate Racemase Muconate Lactonizing
ITG09_23460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG09_23465	COG3639	organic phosphonate transmembrane transporter activity
ITG09_23470	COG3639	organic phosphonate transmembrane transporter activity
ITG09_23515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG09_23520	COG3047	cAMP biosynthetic process
ITG09_23530	COG4221	oxidoreductase activity
ITG09_23535	COG0583	DNA-binding transcription factor activity
ITG09_23540	COG1733	regulation of RNA biosynthetic process
ITG09_23545	COG1028	Short-chain dehydrogenase reductase Sdr
ITG09_23565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG09_23605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG09_23610	COG1595	DNA-templated transcription, initiation
ITG09_23640	COG1901	pseudouridine methyltransferase
ITG09_23750	COG2801	Transposase and inactivated derivatives
ITG09_23760	COG2205	protein histidine kinase activity
ITG09_23845	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG09_23860	COG2964	Protein conserved in bacteria
ITG09_23875	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ITG09_23880	COG3639	organic phosphonate transmembrane transporter activity
ITG09_23885	COG2188	Transcriptional regulator
ITG09_23890	COG3624	Phosphonate C-P lyase system protein PhnG
ITG09_23895	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ITG09_23900	COG3626	phosphonate metabolism
ITG09_23905	COG3627	carbon phosphorus lyase activity
ITG09_23910	COG4107	phosphonate C-P lyase system protein PhnK
ITG09_23915	COG4778	phosphonate C-P lyase system protein PhnL
ITG09_23920	COG3454	Phosphonate metabolism
ITG09_23930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ITG09_23935	COG0110	maltose O-acetyltransferase activity
ITG09_23940	COG0534	Mate efflux family protein
ITG09_23965	COG3385	transposase activity
ITG09_23975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ITG09_23980	COG2999	glutathione oxidoreductase activity
ITG09_23990	COG0673	inositol 2-dehydrogenase activity
ITG09_24010	COG0584	glycerophosphoryl diester phosphodiesterase
ITG09_24015	COG3842	ATPase activity
ITG09_24020	COG0395	ABC-type sugar transport system, permease component
ITG09_24045	COG4067	protein conserved in archaea
ITG09_24045	COG0189	ligase activity
ITG09_24050	COG0189	ligase activity
ITG09_24100	COG2814	Major facilitator Superfamily
ITG09_24110	COG0564	pseudouridine synthase activity
ITG09_24120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG09_24120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG09_24140	COG1131	(ABC) transporter
ITG09_24145	COG2186	Transcriptional regulator
ITG09_24150	COG5001	Diguanylate cyclase
ITG09_24160	COG5001	Diguanylate cyclase
ITG09_24170	COG0745	RESPONSE REGULATOR receiver
ITG09_24175	COG2205	protein histidine kinase activity
ITG09_24180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG09_24240	COG0740	serine-type endopeptidase activity
ITG09_24255	COG1802	Transcriptional regulator
ITG09_24255	COG4626	Terminase
ITG09_24385	COG1192	Involved in chromosome partitioning