locus-tag	class	description
ITG13_00005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG13_00015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ITG13_00025	COG1072	(Pantothenic acid kinase))
ITG13_00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG13_00060	COG0250	Participates in transcription elongation, termination and antitermination
ITG13_00070	COG0081	regulation of translation
ITG13_00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ITG13_00080	COG0222	ribosome binding
ITG13_00095	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ITG13_00100	COG2816	NAD+ diphosphatase activity
ITG13_00110	COG1573	uracil-dna glycosylase
ITG13_00120	COG3068	Protein conserved in bacteria
ITG13_00125	COG1253	flavin adenine dinucleotide binding
ITG13_00140	COG0151	Belongs to the GarS family
ITG13_00145	COG0138	bifunctional purine biosynthesis protein purh
ITG13_00150	COG0789	Transcriptional regulator
ITG13_00155	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG13_00160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG13_00165	COG2264	protein methyltransferase activity
ITG13_00170	COG0439	Biotin carboxylase
ITG13_00175	COG0511	ligase activity, forming carbon-carbon bonds
ITG13_00180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ITG13_00185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG13_00200	COG2814	Major facilitator Superfamily
ITG13_00205	COG0784	Response regulator, receiver
ITG13_00205	COG2198	Histidine kinase
ITG13_00205	COG2205	protein histidine kinase activity
ITG13_00220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_00230	COG3263	regulation of cellular component size
ITG13_00240	COG4232	protein-disulfide reductase activity
ITG13_00245	COG1438	arginine binding
ITG13_00250	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG13_00255	COG0540	Belongs to the ATCase OTCase family
ITG13_00260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ITG13_00275	COG1288	antiporter activity
ITG13_00280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG13_00285	COG1027	Aspartate ammonia-lyase
ITG13_00295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITG13_00305	COG2205	protein histidine kinase activity
ITG13_00310	COG0745	RESPONSE REGULATOR receiver
ITG13_00320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITG13_00330	COG0149	triose-phosphate isomerase activity
ITG13_00340	COG3152	Membrane
ITG13_00355	COG1494	fructose-1,6-bisphosphatase
ITG13_00360	COG3074	FtsZ-dependent cytokinesis
ITG13_00365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG13_00370	COG1575	Belongs to the MenA family. Type 1 subfamily
ITG13_00375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ITG13_00380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ITG13_00390	COG1609	Transcriptional regulator
ITG13_00395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITG13_00400	COG0254	rRNA binding
ITG13_00405	COG0281	malic enzyme
ITG13_00410	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ITG13_00415	COG0626	cystathionine gamma-synthase activity
ITG13_00420	COG0460	homoserine dehydrogenase
ITG13_00420	COG0527	aspartate kinase activity
ITG13_00425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG13_00435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ITG13_00440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG13_00445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ITG13_00460	COG0165	Argininosuccinate lyase
ITG13_00460	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG13_00470	COG0251	oxidation-reduction process
ITG13_00475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG13_00480	COG0678	peroxiredoxin activity
ITG13_00480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG13_00490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ITG13_00525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ITG13_00535	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITG13_00540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG13_00545	COG0546	phosphoglycolate phosphatase activity
ITG13_00550	COG0180	Tryptophanyl-tRNA synthetase
ITG13_00570	COG2356	endonuclease I
ITG13_00575	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG13_00580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ITG13_00590	COG1012	belongs to the aldehyde dehydrogenase family
ITG13_00600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG13_00605	COG3954	Phosphoribulokinase
ITG13_00610	COG3089	Belongs to the UPF0270 family
ITG13_00615	COG0429	hydrolase of the alpha beta-hydrolase fold
ITG13_00625	COG0488	(ABC) transporter
ITG13_00630	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG13_00645	COG1047	Peptidyl-prolyl cis-trans
ITG13_00650	COG1446	asparaginase
ITG13_00655	COG2900	Belongs to the SlyX family
ITG13_00665	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG13_00670	COG2964	Protein conserved in bacteria
ITG13_00675	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ITG13_00680	COG2923	Belongs to the DsrF TusC family
ITG13_00700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG13_00715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ITG13_00720	COG0088	Forms part of the polypeptide exit tunnel
ITG13_00725	COG0089	rRNA binding
ITG13_00730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ITG13_00735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ITG13_00745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ITG13_00750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ITG13_00760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ITG13_00765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ITG13_00770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ITG13_00775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ITG13_00780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ITG13_00785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ITG13_00790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ITG13_00795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ITG13_00800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ITG13_00805	COG1841	ribosomal large subunit assembly
ITG13_00810	COG0200	Binds to the 23S rRNA
ITG13_00815	COG0201	protein transport
ITG13_00820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ITG13_00825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ITG13_00830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ITG13_00835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ITG13_00840	COG0202	RNA polymerase activity
ITG13_00845	COG0203	ribosomal protein L17
ITG13_00860	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG13_00865	COG3061	Opacity-associated protein A
ITG13_00865	COG3266	domain, Protein
ITG13_00875	COG2153	protein acetylation
ITG13_00920	COG0737	Belongs to the 5'-nucleotidase family
ITG13_00925	COG0175	sulfate reduction
ITG13_00930	COG2895	sulfate adenylyltransferase (ATP) activity
ITG13_00935	COG3273	potassium ion transport
ITG13_00935	COG0471	metal ion transport
ITG13_00940	COG0529	Catalyzes the synthesis of activated sulfate
ITG13_00975	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ITG13_00985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG13_00990	COG0729	surface antigen
ITG13_00995	COG2911	Protein conserved in bacteria
ITG13_01000	COG2105	PFAM AIG2 family protein
ITG13_01005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ITG13_01010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG13_01015	COG0163	prenyltransferase activity
ITG13_01020	COG4143	(ABC) transporter
ITG13_01025	COG1178	ABC-type Fe3 transport system permease component
ITG13_01030	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ITG13_01035	COG3028	Belongs to the UPF0307 family
ITG13_01040	COG0312	modulator of DNA gyrase
ITG13_01045	COG2239	Acts as a magnesium transporter
ITG13_01050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_01055	COG1660	Displays ATPase and GTPase activities
ITG13_01060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_01065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG13_01075	COG1137	ATPase activity
ITG13_01080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ITG13_01090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ITG13_01095	COG0517	IMP dehydrogenase activity
ITG13_01095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ITG13_01105	COG1127	ABC transporter
ITG13_01110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ITG13_01115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG13_01120	COG2854	intermembrane phospholipid transfer
ITG13_01130	COG5007	Belongs to the BolA IbaG family
ITG13_01135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ITG13_01140	COG0204	Acyl-transferase
ITG13_01145	COG0251	oxidation-reduction process
ITG13_01150	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG13_01180	COG0456	acetyltransferase
ITG13_01190	COG0525	valine-tRNA ligase activity
ITG13_01195	COG2927	DNA polymerase III (CHI subunit)
ITG13_01200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG13_01205	COG0795	lipopolysaccharide-transporting ATPase activity
ITG13_01210	COG0795	lipopolysaccharide-transporting ATPase activity
ITG13_01325	COG0840	transmembrane signaling receptor activity
ITG13_01365	COG0741	lytic transglycosylase activity
ITG13_01370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ITG13_01385	COG2066	Belongs to the glutaminase family
ITG13_01390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITG13_01395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ITG13_01410	COG0762	integral membrane protein
ITG13_01415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITG13_01420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ITG13_01435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ITG13_01440	COG1678	Uncharacterized ACR, COG1678
ITG13_01445	COG0189	ligase activity
ITG13_01450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ITG13_01460	COG2356	endonuclease I
ITG13_01465	COG3091	SprT-like family
ITG13_01475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ITG13_01480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG13_01495	COG0191	fructose-bisphosphate aldolase activity
ITG13_01500	COG0668	transmembrane transport
ITG13_01505	COG1279	arginine transmembrane transporter activity
ITG13_01520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG13_01525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ITG13_01530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ITG13_01540	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ITG13_01545	COG3079	Belongs to the UPF0149 family
ITG13_01550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG13_01555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG13_01570	COG0354	folic acid binding
ITG13_01575	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ITG13_01585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ITG13_01590	COG1595	DNA-templated transcription, initiation
ITG13_01610	COG0481	GTPase activity
ITG13_01620	COG0571	ribonuclease III activity
ITG13_01625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ITG13_01630	COG1381	Involved in DNA repair and RecF pathway recombination
ITG13_01635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ITG13_01640	COG0736	holo-[acyl-carrier-protein] synthase activity
ITG13_01645	COG4999	Histidine kinase
ITG13_01645	COG3850	Histidine kinase
ITG13_01645	COG2205	protein histidine kinase activity
ITG13_01645	COG3437	response regulator, receiver
ITG13_01650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG13_01655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG13_01660	COG3956	TIGRFAM MazG family protein
ITG13_01665	COG0504	CTP synthase activity
ITG13_01670	COG0148	phosphopyruvate hydratase activity
ITG13_01675	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ITG13_01680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ITG13_01690	COG0585	pseudouridine synthase activity
ITG13_01695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ITG13_01700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ITG13_01710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ITG13_01715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ITG13_01720	COG1546	Belongs to the CinA family
ITG13_01725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG13_01735	COG0527	aspartate kinase activity
ITG13_01795	COG3630	sodium ion export across plasma membrane
ITG13_01800	COG5016	pyruvate
ITG13_01800	COG0511	ligase activity, forming carbon-carbon bonds
ITG13_01805	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ITG13_01815	COG1238	metal cluster binding
ITG13_01820	COG0612	Peptidase, M16
ITG13_01825	COG2918	glutathione biosynthetic process
ITG13_01835	COG1854	S-ribosylhomocysteine lyase activity
ITG13_01840	COG4536	flavin adenine dinucleotide binding
ITG13_01845	COG4137	Cytochrome C assembly protein
ITG13_01850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ITG13_01855	COG0228	four-way junction DNA binding
ITG13_01860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ITG13_01865	COG0336	Belongs to the RNA methyltransferase TrmD family
ITG13_01870	COG0335	large ribosomal subunit rRNA binding
ITG13_01880	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ITG13_01885	COG0237	dephospho-CoA kinase activity
ITG13_01895	COG1459	type II secretion system
ITG13_01900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG13_01910	COG0157	Belongs to the NadC ModD family
ITG13_01920	COG2186	Transcriptional regulator
ITG13_01925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ITG13_01930	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG13_01935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG13_01950	COG0288	reversible hydration of carbon dioxide
ITG13_01955	COG0659	secondary active sulfate transmembrane transporter activity
ITG13_01960	COG1131	(ABC) transporter
ITG13_01965	COG0842	Transport permease protein
ITG13_01970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ITG13_01975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ITG13_01980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG13_02000	COG1489	DNA binding
ITG13_02005	COG1643	Atp-dependent helicase
ITG13_02010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG13_02015	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITG13_02020	COG1049	propionate catabolic process, 2-methylcitrate cycle
ITG13_02035	COG0004	ammonium transporteR
ITG13_02040	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG13_02050	COG3842	ATPase activity
ITG13_02055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG13_02070	COG2971	BadF BadG BcrA BcrD
ITG13_02080	COG4608	Belongs to the ABC transporter superfamily
ITG13_02085	COG0444	Belongs to the ABC transporter superfamily
ITG13_02090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG13_02100	COG0747	negative chemotaxis
ITG13_02110	COG2813	Specifically methylates the guanine in position
ITG13_02115	COG0628	permease
ITG13_02120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ITG13_02125	COG0316	Belongs to the HesB IscA family
ITG13_02140	COG0739	heme binding
ITG13_02145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG13_02150	COG2239	Acts as a magnesium transporter
ITG13_02155	COG2027	D-alanyl-D-alanine carboxypeptidase
ITG13_02160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG13_02165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG13_02170	COG1534	Rna-binding protein
ITG13_02175	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ITG13_02180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITG13_02185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ITG13_02190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG13_02195	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG13_02210	COG0779	Required for maturation of 30S ribosomal subunits
ITG13_02215	COG0195	Participates in both transcription termination and antitermination
ITG13_02220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ITG13_02225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ITG13_02230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ITG13_02235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ITG13_02240	COG1185	polyribonucleotide nucleotidyltransferase activity
ITG13_02255	COG0534	Mate efflux family protein
ITG13_02260	COG0826	peptidase U32
ITG13_02265	COG0826	peptidase U32
ITG13_02275	COG3154	lipid carrier protein
ITG13_02280	COG3153	acetyltransferase
ITG13_02295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ITG13_02305	COG0084	hydrolase, TatD family'
ITG13_02310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG13_02315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ITG13_02320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ITG13_02330	COG0813	purine-nucleoside phosphorylase activity
ITG13_02340	COG0560	Phosphoserine phosphatase
ITG13_02350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ITG13_02355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG13_02385	COG4628	conserved protein (DUF2132)
ITG13_02405	COG1022	Amp-dependent synthetase and ligase
ITG13_02440	COG4964	Belongs to the GSP D family
ITG13_02500	COG2059	Chromate
ITG13_02505	COG0583	DNA-binding transcription factor activity
ITG13_02510	COG1609	Transcriptional regulator
ITG13_02520	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_02525	COG0534	Mate efflux family protein
ITG13_02535	COG1175	transmembrane transport
ITG13_02540	COG0395	ABC-type sugar transport system, permease component
ITG13_02550	COG3250	beta-galactosidase activity
ITG13_02555	COG0531	amino acid
ITG13_02560	COG0531	amino acid
ITG13_02565	COG2731	YhcH YjgK YiaL family protein
ITG13_02570	COG3250	beta-galactosidase activity
ITG13_02575	COG1609	Transcriptional regulator
ITG13_02580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG13_02585	COG1085	galactose-1-phosphate uridylyltransferase
ITG13_02595	COG2017	converts alpha-aldose to the beta-anomer
ITG13_02600	COG1609	Transcriptional regulator
ITG13_02605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG13_02620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG13_02640	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG13_02645	COG2252	PERMEase
ITG13_02650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ITG13_02655	COG1073	alpha beta
ITG13_02670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ITG13_02675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ITG13_02680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG13_02680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG13_02700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG13_02705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ITG13_02710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITG13_02715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ITG13_02720	COG0142	geranyltranstransferase activity
ITG13_02725	COG1722	exodeoxyribonuclease VII activity
ITG13_02730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG13_02740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG13_02740	COG0301	tRNA thio-modification
ITG13_02745	COG0583	DNA-binding transcription factor activity
ITG13_02760	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ITG13_02765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG13_02770	COG1611	Belongs to the LOG family
ITG13_02785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG13_02785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG13_02795	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ITG13_02800	COG1464	Belongs to the NlpA lipoprotein family
ITG13_02805	COG2011	ABC-type metal ion transport system permease component
ITG13_02810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ITG13_02815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG13_02825	COG1609	Transcriptional regulator
ITG13_02830	COG1263	PTS System
ITG13_02830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG13_02835	COG0366	Alpha amylase catalytic
ITG13_02855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ITG13_02880	COG0442	prolyl-tRNA aminoacylation
ITG13_02885	COG1720	tRNA m6t6A37 methyltransferase activity
ITG13_02890	COG0254	rRNA binding
ITG13_02900	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG13_02910	COG1671	Belongs to the UPF0178 family
ITG13_02935	COG3098	single-species biofilm formation
ITG13_02940	COG0564	pseudouridine synthase activity
ITG13_02950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ITG13_02955	COG0024	Methionine aminopeptidase
ITG13_02960	COG0052	Belongs to the universal ribosomal protein uS2 family
ITG13_02965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ITG13_02970	COG0528	UMP kinase activity
ITG13_02975	COG0233	cytoplasmic translational termination
ITG13_02980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ITG13_02985	COG0575	Belongs to the CDS family
ITG13_02995	COG0750	zinc metalloprotease
ITG13_03005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ITG13_03010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG13_03015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITG13_03020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG13_03030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ITG13_03035	COG0587	DNA-directed DNA polymerase activity
ITG13_03040	COG0825	malonyl-CoA metabolic process
ITG13_03045	COG0037	tRNA processing
ITG13_03055	COG0347	Belongs to the P(II) protein family
ITG13_03060	COG3021	interspecies interaction between organisms
ITG13_03070	COG1388	LysM domain
ITG13_03070	COG0741	lytic transglycosylase activity
ITG13_03075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG13_03080	COG2226	methyltransferase
ITG13_03085	COG0328	RNA-DNA hybrid ribonuclease activity
ITG13_03090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITG13_03100	COG1960	acyl-CoA dehydrogenase activity
ITG13_03105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG13_03110	COG0121	glutamine amidotransferase
ITG13_03115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ITG13_03120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ITG13_03130	COG2233	PERMEase
ITG13_03150	COG1393	Belongs to the ArsC family
ITG13_03155	COG4783	chaperone-mediated protein folding
ITG13_03170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG13_03175	COG2716	regulation of RNA biosynthetic process
ITG13_03180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITG13_03185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ITG13_03200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG13_03205	COG1393	Belongs to the ArsC family
ITG13_03230	COG2837	iron assimilation
ITG13_03235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG13_03240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG13_03245	COG2190	(PTS) system
ITG13_03255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_03265	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ITG13_03270	COG3115	cell septum assembly
ITG13_03275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ITG13_03295	COG0789	Transcriptional regulator
ITG13_03305	COG0330	HflC and HflK could
ITG13_03310	COG3118	belongs to the thioredoxin family
ITG13_03315	COG0300	oxidoreductase activity
ITG13_03320	COG1090	epimerase
ITG13_03345	COG0622	Phosphoesterase
ITG13_03360	COG3710	Transcriptional regulator
ITG13_03365	COG0326	Molecular chaperone. Has ATPase activity
ITG13_03370	COG0563	adenylate kinase activity
ITG13_03375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ITG13_03380	COG3104	oligopeptide transport
ITG13_03390	COG0367	asparagine synthase
ITG13_03395	COG4651	solute:proton antiporter activity
ITG13_03395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG13_03400	COG1940	carbohydrate kinase activity
ITG13_03400	COG1846	Transcriptional regulator
ITG13_03405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITG13_03410	COG1263	PTS System
ITG13_03410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG13_03410	COG2190	(PTS) system
ITG13_03415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ITG13_03440	COG0596	Alpha beta hydrolase
ITG13_03445	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ITG13_03450	COG0033	Phosphoglucomutase
ITG13_03460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ITG13_03475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ITG13_03480	COG1053	succinate dehydrogenase
ITG13_03485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG13_03490	COG0567	Dehydrogenase, E1 component
ITG13_03495	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG13_03500	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG13_03515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG13_03520	COG1121	(ABC) transporter
ITG13_03525	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ITG13_03535	COG1918	ferrous iron import across plasma membrane
ITG13_03555	COG0018	arginyl-trna synthetase
ITG13_03560	COG3102	Protein conserved in bacteria
ITG13_03565	COG0788	formyltetrahydrofolate deformylase activity
ITG13_03575	COG1199	ATP-dependent helicase activity
ITG13_03580	COG1214	PFAM Peptidase M22, glycoprotease
ITG13_03595	COG0596	Alpha beta hydrolase
ITG13_03600	COG0318	PFAM AMP-dependent synthetase and ligase
ITG13_03605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ITG13_03610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ITG13_03615	COG2894	cell division
ITG13_03620	COG0850	regulation of cytokinetic process
ITG13_03625	COG3100	YcgL domain-containing protein
ITG13_03630	COG2951	lytic endotransglycosylase activity
ITG13_03635	COG0583	DNA-binding transcription factor activity
ITG13_03640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG13_03650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ITG13_03660	COG0515	serine threonine protein kinase
ITG13_03660	COG2815	serine threonine protein kinase
ITG13_03675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ITG13_03680	COG2860	membrane
ITG13_03685	COG3101	peptidyl-lysine hydroxylation
ITG13_03695	COG0431	NADPH-dependent FMN reductase
ITG13_03705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITG13_03710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG13_03715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG13_03725	COG0101	tRNA pseudouridine synthase activity
ITG13_03730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ITG13_03735	COG0285	dihydrofolate synthase activity
ITG13_03740	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ITG13_03745	COG1286	toxin biosynthetic process
ITG13_03750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ITG13_03755	COG0583	DNA-binding transcription factor activity
ITG13_03760	COG0745	RESPONSE REGULATOR receiver
ITG13_03770	COG2832	Protein of unknown function (DUF454)
ITG13_03775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ITG13_03780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ITG13_03785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ITG13_03790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ITG13_03805	COG2983	Belongs to the UPF0260 family
ITG13_03825	COG2226	methyltransferase
ITG13_03840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG13_03845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG13_03855	COG3139	Protein of unknown function (DUF1315)
ITG13_03860	COG0252	asparaginase activity
ITG13_03865	COG0616	signal peptide processing
ITG13_03870	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG13_03870	COG1902	pentaerythritol trinitrate reductase activity
ITG13_03875	COG0778	Nitroreductase
ITG13_03880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG13_03895	COG0123	including yeast histone deacetylase and acetoin utilization protein
ITG13_03900	COG0840	transmembrane signaling receptor activity
ITG13_03915	COG3083	sulfuric ester hydrolase activity
ITG13_03920	COG3082	Protein of unknown function (DUF1414)
ITG13_03925	COG3081	Nucleoid-associated protein
ITG13_03940	COG1757	Na H antiporter
ITG13_03945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG13_03955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG13_03960	COG2095	MarC family integral membrane protein
ITG13_03965	COG1012	belongs to the aldehyde dehydrogenase family
ITG13_03965	COG1454	alcohol dehydrogenase
ITG13_03980	COG0840	transmembrane signaling receptor activity
ITG13_03995	COG2197	response regulator
ITG13_04000	COG2199	diguanylate cyclase activity
ITG13_04000	COG2200	EAL domain
ITG13_04000	COG2202	Pas domain
ITG13_04005	COG2198	Histidine kinase
ITG13_04005	COG0784	Response regulator, receiver
ITG13_04005	COG2205	protein histidine kinase activity
ITG13_04005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_04010	COG3706	GGDEF domain
ITG13_04015	COG2267	carboxylic ester hydrolase activity
ITG13_04035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ITG13_04045	COG2056	Na+-H+ antiporter family
ITG13_04050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITG13_04065	COG0346	lactoylglutathione lyase activity
ITG13_04070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ITG13_04075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ITG13_04080	COG4660	Part of a membrane complex involved in electron transport
ITG13_04085	COG4659	FMN binding
ITG13_04090	COG4658	electron transport chain
ITG13_04095	COG4656	Part of a membrane complex involved in electron transport
ITG13_04100	COG2878	Part of a membrane complex involved in electron transport
ITG13_04105	COG4657	Part of a membrane complex involved in electron transport
ITG13_04115	COG0556	nucleotide-excision repair
ITG13_04120	COG2204	response regulator
ITG13_04125	COG2198	Histidine kinase
ITG13_04130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ITG13_04135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ITG13_04140	COG0521	Mo-molybdopterin cofactor biosynthetic process
ITG13_04145	COG0315	cyclic pyranopterin monophosphate synthase activity
ITG13_04150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ITG13_04155	COG0314	molybdopterin synthase activity
ITG13_04165	COG0601	transmembrane transport
ITG13_04170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG13_04175	COG0444	Belongs to the ABC transporter superfamily
ITG13_04185	COG0435	Glutathione S-transferase
ITG13_04190	COG0857	belongs to the CobB CobQ family
ITG13_04190	COG0280	phosphate acetyltransferase
ITG13_04195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG13_04200	COG3092	negative regulation of chromosome organization
ITG13_04215	COG3706	GGDEF domain
ITG13_04220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG13_04225	COG0653	protein targeting
ITG13_04230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG13_04235	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG13_04240	COG2186	Transcriptional regulator
ITG13_04250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG13_04250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG13_04255	COG0489	protein tyrosine kinase activity
ITG13_04260	COG0572	uridine kinase
ITG13_04265	COG2982	Protein involved in outer membrane biogenesis
ITG13_04270	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ITG13_04275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITG13_04280	COG0659	secondary active sulfate transmembrane transporter activity
ITG13_04285	COG1530	ribonuclease E activity
ITG13_04290	COG0564	pseudouridine synthase activity
ITG13_04300	COG1399	metal-binding, possibly nucleic acid-binding protein
ITG13_04305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ITG13_04310	COG0416	fatty acid biosynthetic process
ITG13_04315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG13_04340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG13_04345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITG13_04360	COG0084	hydrolase, TatD family'
ITG13_04385	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG13_04390	COG0469	pyruvate kinase activity
ITG13_04395	COG1940	carbohydrate kinase activity
ITG13_04400	COG0784	Response regulator, receiver
ITG13_04400	COG0835	chemotaxis
ITG13_04415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG13_04420	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_04425	COG0616	signal peptide processing
ITG13_04430	COG2719	SpoVR family
ITG13_04435	COG2718	Belongs to the UPF0229 family
ITG13_04440	COG2766	serine protein kinase
ITG13_04450	COG3013	Belongs to the UPF0304 family
ITG13_04455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG13_04465	COG1882	Formate acetyltransferase
ITG13_04495	COG4160	amino acid transport
ITG13_04505	COG0708	Exodeoxyribonuclease III
ITG13_04510	COG1770	oligopeptidase
ITG13_04515	COG2814	Major facilitator Superfamily
ITG13_04520	COG0840	transmembrane signaling receptor activity
ITG13_04525	COG2850	peptidyl-arginine hydroxylation
ITG13_04545	COG1199	ATP-dependent helicase activity
ITG13_04550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG13_04555	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG13_04560	COG1187	pseudouridine synthase activity
ITG13_04570	COG1278	Cold shock
ITG13_04575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ITG13_04580	COG0542	response to heat
ITG13_04590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ITG13_04595	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ITG13_04600	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ITG13_04610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ITG13_04620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG13_04625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG13_04630	COG0297	glycogen (starch) synthase activity
ITG13_04650	COG3070	regulator of competence-specific genes
ITG13_04655	COG1609	Transcriptional regulator
ITG13_04660	COG3381	protein complex oligomerization
ITG13_04665	COG0745	RESPONSE REGULATOR receiver
ITG13_04670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG13_04675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG13_04680	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ITG13_04685	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ITG13_04690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ITG13_04695	COG3383	formate dehydrogenase (NAD+) activity
ITG13_04710	COG0189	ligase activity
ITG13_04710	COG4067	protein conserved in archaea
ITG13_04715	COG0500	methyltransferase
ITG13_04720	COG4106	trans-aconitate 2-methyltransferase activity
ITG13_04725	COG1801	Protein of unknown function DUF72
ITG13_04730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ITG13_04735	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ITG13_04745	COG0632	four-way junction helicase activity
ITG13_04750	COG2255	four-way junction helicase activity
ITG13_04755	COG1271	oxidase subunit
ITG13_04760	COG1294	oxidase, subunit
ITG13_04765	COG4890	Cyd operon protein YbgT
ITG13_04775	COG0824	Thioesterase
ITG13_04780	COG0811	peptide transport
ITG13_04795	COG0823	Involved in the tonB-independent uptake of proteins
ITG13_04800	COG2885	chlorophyll binding
ITG13_04805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ITG13_04810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ITG13_04825	COG5002	protein histidine kinase activity
ITG13_04825	COG0784	Response regulator, receiver
ITG13_04840	COG0786	glutamate:sodium symporter activity
ITG13_04845	COG1349	DNA-binding transcription factor activity
ITG13_04865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG13_04910	COG0583	DNA-binding transcription factor activity
ITG13_04915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG13_04935	COG0745	RESPONSE REGULATOR receiver
ITG13_04940	COG0463	Glycosyl transferase, family 2
ITG13_04955	COG3135	benzoate transporter
ITG13_04960	COG1396	sequence-specific DNA binding
ITG13_04965	COG1032	radical SAM domain protein
ITG13_04980	COG0583	DNA-binding transcription factor activity
ITG13_04985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITG13_04995	COG2350	Protein conserved in bacteria
ITG13_05000	COG1607	acyl-coa hydrolase
ITG13_05005	COG2917	probably involved in intracellular septation
ITG13_05015	COG0583	DNA-binding transcription factor activity
ITG13_05025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_05035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG13_05045	COG1301	dicarboxylic acid transport
ITG13_05050	COG0159	tryptophan synthase activity
ITG13_05055	COG0133	tryptophan synthase activity
ITG13_05060	COG0134	indole-3-glycerol-phosphate synthase activity
ITG13_05060	COG0135	phosphoribosylanthranilate isomerase activity
ITG13_05065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ITG13_05070	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG13_05075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG13_05085	COG0613	PHP domain protein
ITG13_05090	COG0009	L-threonylcarbamoyladenylate synthase
ITG13_05095	COG1187	pseudouridine synthase activity
ITG13_05110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG13_05120	COG0417	DNA replication proofreading
ITG13_05125	COG2197	response regulator
ITG13_05130	COG0322	excinuclease ABC activity
ITG13_05170	COG0019	diaminopimelate decarboxylase activity
ITG13_05185	COG1058	Belongs to the CinA family
ITG13_05185	COG1546	Belongs to the CinA family
ITG13_05190	COG3302	dmso reductase anchor subunit
ITG13_05195	COG0437	4 iron, 4 sulfur cluster binding
ITG13_05200	COG0243	molybdopterin cofactor binding
ITG13_05205	COG3381	protein complex oligomerization
ITG13_05220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG13_05225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG13_05230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG13_05250	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ITG13_05260	COG0437	4 iron, 4 sulfur cluster binding
ITG13_05265	COG3301	Polysulphide reductase, NrfD
ITG13_05270	COG1138	Cytochrome C-type biogenesis protein
ITG13_05280	COG3088	subunit of a heme lyase
ITG13_05280	COG4235	cytochrome complex assembly
ITG13_05290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG13_05315	COG2989	Protein conserved in bacteria
ITG13_05320	COG3108	Peptidase M15
ITG13_05325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG13_05340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ITG13_05365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG13_05370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG13_05375	COG0840	transmembrane signaling receptor activity
ITG13_05380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ITG13_05385	COG4988	ABC transporter
ITG13_05390	COG0492	ferredoxin-NADP+ reductase activity
ITG13_05405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG13_05420	COG2199	diguanylate cyclase activity
ITG13_05435	COG0471	metal ion transport
ITG13_05440	COG2949	membrane
ITG13_05445	COG0281	malic enzyme
ITG13_05450	COG1643	Atp-dependent helicase
ITG13_05460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ITG13_05495	COG0247	lactate metabolic process
ITG13_05495	COG0277	FAD linked oxidase domain protein
ITG13_05510	COG2986	histidine ammonia-lyase
ITG13_05515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ITG13_05520	COG0010	Belongs to the arginase family
ITG13_05525	COG1228	amidohydrolase
ITG13_05535	COG4326	sporulation control protein
ITG13_05555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ITG13_05560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ITG13_05565	COG3097	Belongs to the UPF0267 family
ITG13_05580	COG0488	(ABC) transporter
ITG13_05585	COG1309	transcriptional regulator
ITG13_05595	COG1166	arginine decarboxylase activity
ITG13_05600	COG0010	Belongs to the arginase family
ITG13_05610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ITG13_05615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_05620	COG0800	Aldolase
ITG13_05625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG13_05630	COG1917	Cupin 2, conserved barrel domain protein
ITG13_05655	COG3639	organic phosphonate transmembrane transporter activity
ITG13_05660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG13_05670	COG2186	Transcriptional regulator
ITG13_05685	COG3181	Tripartite tricarboxylate transporter family receptor
ITG13_05695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_05710	COG0840	transmembrane signaling receptor activity
ITG13_05745	COG2186	Transcriptional regulator
ITG13_05750	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_05755	COG2186	Transcriptional regulator
ITG13_05760	COG0517	IMP dehydrogenase activity
ITG13_05765	COG2176	DNA-directed DNA polymerase activity
ITG13_05785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_05810	COG3033	Beta-eliminating lyase
ITG13_05875	COG0471	metal ion transport
ITG13_05880	COG4191	Histidine kinase
ITG13_05880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_05905	COG0454	-acetyltransferase
ITG13_05935	COG0730	response to heat
ITG13_05950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ITG13_05955	COG1280	lysine exporter protein (LysE YggA)
ITG13_05960	COG1115	amino acid carrier protein
ITG13_05975	COG1115	amino acid carrier protein
ITG13_05990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_06005	COG3290	protein histidine kinase activity
ITG13_06010	COG4565	transcriptional regulatory protein
ITG13_06015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ITG13_06020	COG0363	glucosamine-6-phosphate deaminase activity
ITG13_06025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG13_06035	COG4628	conserved protein (DUF2132)
ITG13_06065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG13_06075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ITG13_06080	COG0372	Belongs to the citrate synthase family
ITG13_06085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ITG13_06090	COG2828	Protein conserved in bacteria
ITG13_06120	COG0561	phosphatase activity
ITG13_06125	COG0602	queuosine metabolic process
ITG13_06130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ITG13_06135	COG3706	GGDEF domain
ITG13_06145	COG2885	chlorophyll binding
ITG13_06315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG13_06325	COG1254	Belongs to the acylphosphatase family
ITG13_06330	COG2920	part of a sulfur-relay system
ITG13_06335	COG0670	Belongs to the BI1 family
ITG13_06340	COG1126	abc transporter atp-binding protein
ITG13_06345	COG0765	amino acid transport
ITG13_06350	COG4597	amino acid ABC transporter
ITG13_06355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_06365	COG1666	GTP binding
ITG13_06370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG13_06375	COG0574	Belongs to the PEP-utilizing enzyme family
ITG13_06375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG13_06390	COG2996	Protein conserved in bacteria
ITG13_06395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG13_06395	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ITG13_06400	COG3008	intermembrane lipid transfer
ITG13_06405	COG2995	paraquat-inducible protein a
ITG13_06410	COG1132	(ABC) transporter
ITG13_06415	COG1956	GAF domain-containing protein
ITG13_06420	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ITG13_06435	COG0308	aminopeptidase N
ITG13_06445	COG2902	Dehydrogenase
ITG13_06450	COG0167	dihydroorotate dehydrogenase activity
ITG13_06460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG13_06460	COG0116	Belongs to the methyltransferase superfamily
ITG13_06470	COG0488	(ABC) transporter
ITG13_06490	COG1067	ATP-dependent peptidase activity
ITG13_06495	COG3120	sequence-specific DNA binding
ITG13_06570	COG4128	Pfam Zonular occludens toxin
ITG13_06605	COG2176	DNA-directed DNA polymerase activity
ITG13_06605	COG5002	protein histidine kinase activity
ITG13_06615	COG0784	Response regulator, receiver
ITG13_06615	COG2205	protein histidine kinase activity
ITG13_06630	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG13_06645	COG2010	Cytochrome c
ITG13_06655	COG2217	Heavy metal translocating P-type atpase
ITG13_06670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG13_06675	COG0589	response to stress
ITG13_06685	COG0037	tRNA processing
ITG13_06705	COG3842	ATPase activity
ITG13_06715	COG1177	transmembrane transport
ITG13_06725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ITG13_06730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ITG13_06735	COG0004	ammonium transporteR
ITG13_06750	COG0437	4 iron, 4 sulfur cluster binding
ITG13_06755	COG0243	molybdopterin cofactor binding
ITG13_06755	COG3383	formate dehydrogenase (NAD+) activity
ITG13_06765	COG3381	protein complex oligomerization
ITG13_06785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ITG13_06790	COG0488	(ABC) transporter
ITG13_06810	COG4191	Histidine kinase
ITG13_06815	COG2204	response regulator
ITG13_06825	COG4662	Binding-protein-dependent transport system inner membrane component
ITG13_06830	COG3842	ATPase activity
ITG13_06835	COG0746	molybdenum cofactor guanylyltransferase activity
ITG13_06840	COG0303	'Molybdopterin
ITG13_06850	COG1940	carbohydrate kinase activity
ITG13_06855	COG3148	PFAM DTW domain containing protein
ITG13_06870	COG0791	NLP P60 protein
ITG13_06880	COG3001	Fructosamine kinase
ITG13_06890	COG0307	riboflavin synthase, alpha
ITG13_06895	COG0534	Mate efflux family protein
ITG13_06900	COG1793	dna ligase
ITG13_06910	COG2885	chlorophyll binding
ITG13_06910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ITG13_06930	COG4176	ABC-type proline glycine betaine transport system permease component
ITG13_06935	COG4175	Glycine betaine
ITG13_06935	COG3448	diguanylate cyclase activity
ITG13_06945	COG2204	response regulator
ITG13_06980	COG1215	transferase activity, transferring glycosyl groups
ITG13_06985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG13_06990	COG0583	DNA-binding transcription factor activity
ITG13_07015	COG1742	UPF0060 membrane protein
ITG13_07045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ITG13_07065	COG4160	amino acid transport
ITG13_07070	COG4215	(ABC) transporter
ITG13_07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_07080	COG1126	abc transporter atp-binding protein
ITG13_07095	COG0826	peptidase U32
ITG13_07110	COG0786	glutamate:sodium symporter activity
ITG13_07145	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_07155	COG0653	protein targeting
ITG13_07190	COG0346	lactoylglutathione lyase activity
ITG13_07195	COG1280	lysine exporter protein (LysE YggA)
ITG13_07240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG13_07250	COG0110	maltose O-acetyltransferase activity
ITG13_07260	COG1187	pseudouridine synthase activity
ITG13_07275	COG0494	nUDIX hydrolase
ITG13_07300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG13_07310	COG2271	Major facilitator Superfamily
ITG13_07330	COG4774	siderophore transport
ITG13_07350	COG4615	Cyclic peptide transporter
ITG13_07360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG13_07365	COG1120	ATPase activity
ITG13_07385	COG0589	response to stress
ITG13_07390	COG0415	Belongs to the DNA photolyase family
ITG13_07395	COG3046	protein related to deoxyribodipyrimidine photolyase
ITG13_07415	COG0419	ATPase involved in DNA repair
ITG13_07420	COG0420	3'-5' exonuclease activity
ITG13_07435	COG0454	-acetyltransferase
ITG13_07440	COG2226	methyltransferase
ITG13_07445	COG4771	TonB-dependent receptor
ITG13_07455	COG3469	chitinase activity
ITG13_07470	COG0840	transmembrane signaling receptor activity
ITG13_07485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG13_07490	COG5002	protein histidine kinase activity
ITG13_07490	COG5001	Diguanylate cyclase
ITG13_07535	COG0455	bacterial-type flagellum organization
ITG13_07545	COG4964	Belongs to the GSP D family
ITG13_07565	COG0583	DNA-binding transcription factor activity
ITG13_07585	COG3706	GGDEF domain
ITG13_07590	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG13_07605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ITG13_07610	COG3063	Type IV pilus biogenesis stability protein PilW
ITG13_07620	COG1451	nucleotide metabolic process
ITG13_07630	COG0583	DNA-binding transcription factor activity
ITG13_07635	COG2814	Major facilitator Superfamily
ITG13_07655	COG1247	-acetyltransferase
ITG13_07675	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ITG13_07680	COG4139	cobalamin transport
ITG13_07685	COG2988	succinylglutamate desuccinylase activity
ITG13_07705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ITG13_07710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ITG13_07720	COG0702	epimerase
ITG13_07725	COG1823	symporter activity
ITG13_07735	COG4989	oxidoreductase activity
ITG13_07750	COG3122	Protein conserved in bacteria
ITG13_07755	COG3568	Endonuclease Exonuclease Phosphatase
ITG13_07830	COG2925	Exonuclease
ITG13_07840	COG1346	cytolysis
ITG13_07845	COG0295	cytidine deaminase activity
ITG13_07855	COG0500	methyltransferase
ITG13_07865	COG0776	regulation of translation
ITG13_07875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG13_07885	COG0523	cobalamin synthesis protein
ITG13_07890	COG2988	succinylglutamate desuccinylase activity
ITG13_07900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG13_07915	COG2175	clavaminate synthase activity
ITG13_07925	COG0583	DNA-binding transcription factor activity
ITG13_07955	COG0776	regulation of translation
ITG13_07980	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ITG13_08035	COG1464	Belongs to the NlpA lipoprotein family
ITG13_08050	COG0784	Response regulator, receiver
ITG13_08050	COG2205	protein histidine kinase activity
ITG13_08070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG13_08075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG13_08080	COG0302	gtp cyclohydrolase
ITG13_08105	COG0596	Alpha beta hydrolase
ITG13_08115	COG0210	DNA helicase
ITG13_08120	COG0072	phenylalanine-tRNA ligase activity
ITG13_08120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG13_08125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ITG13_08165	COG1643	Atp-dependent helicase
ITG13_08195	COG3710	Transcriptional regulator
ITG13_08225	COG3706	GGDEF domain
ITG13_08240	COG0443	Heat shock 70 kDa protein
ITG13_08255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG13_08275	COG3106	COG3106 Predicted ATPase
ITG13_08290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG13_08295	COG5002	protein histidine kinase activity
ITG13_08295	COG0784	Response regulator, receiver
ITG13_08305	COG0494	nUDIX hydrolase
ITG13_08310	COG0814	amino acid
ITG13_08315	COG1760	l-serine dehydratase
ITG13_08320	COG0814	amino acid
ITG13_08330	COG0840	transmembrane signaling receptor activity
ITG13_08335	COG0659	secondary active sulfate transmembrane transporter activity
ITG13_08340	COG0017	Asparaginyl-tRNA synthetase
ITG13_08350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG13_08360	COG2770	Histidine kinase
ITG13_08360	COG3437	response regulator, receiver
ITG13_08365	COG1448	Aminotransferase
ITG13_08395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ITG13_08405	COG3852	Histidine kinase
ITG13_08410	COG2204	response regulator
ITG13_08420	COG3070	regulator of competence-specific genes
ITG13_08430	COG2431	L-lysine efflux transmembrane transporter activity
ITG13_08440	COG0076	glutamate decarboxylase activity
ITG13_08445	COG1737	Transcriptional regulator
ITG13_08455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG13_08460	COG3273	potassium ion transport
ITG13_08460	COG2985	domain, Protein
ITG13_08465	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG13_08485	COG3047	cAMP biosynthetic process
ITG13_08485	COG2885	chlorophyll binding
ITG13_08490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG13_08510	COG0534	Mate efflux family protein
ITG13_08515	COG0702	epimerase
ITG13_08525	COG2814	Major facilitator Superfamily
ITG13_08535	COG1061	Type III restriction enzyme res subunit
ITG13_08550	COG0642	Histidine kinase
ITG13_08570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ITG13_08585	COG2059	Chromate
ITG13_08590	COG2059	Chromate
ITG13_08605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITG13_08620	COG1737	Transcriptional regulator
ITG13_08630	COG0765	amino acid transport
ITG13_08635	COG0765	amino acid transport
ITG13_08640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_08655	COG0583	DNA-binding transcription factor activity
ITG13_08665	COG1609	Transcriptional regulator
ITG13_08685	COG3842	ATPase activity
ITG13_08735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG13_08735	COG3008	intermembrane lipid transfer
ITG13_08740	COG2995	paraquat-inducible protein a
ITG13_08745	COG0583	DNA-binding transcription factor activity
ITG13_08755	COG2113	Glycine betaine
ITG13_08760	COG4176	ABC-type proline glycine betaine transport system permease component
ITG13_08785	COG2866	Carboxypeptidase
ITG13_08795	COG1280	lysine exporter protein (LysE YggA)
ITG13_08800	COG0513	Belongs to the DEAD box helicase family
ITG13_08820	COG3313	Fe-S protein
ITG13_08830	COG4134	Bacterial extracellular solute-binding protein
ITG13_08835	COG4135	transport system, permease component
ITG13_08840	COG4136	ATPase activity
ITG13_08845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ITG13_08850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG13_08850	COG0116	Belongs to the methyltransferase superfamily
ITG13_08855	COG0564	pseudouridine synthase activity
ITG13_08865	COG0733	neurotransmitter:sodium symporter activity
ITG13_08875	COG0626	cystathionine gamma-synthase activity
ITG13_08890	COG2818	Glycosylase
ITG13_08905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_08910	COG1983	PspC domain protein
ITG13_08920	COG1842	Phage shock protein A
ITG13_08925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITG13_08930	COG4166	transmembrane transport
ITG13_08935	COG4168	peptide transport system, permease
ITG13_08950	COG4172	Belongs to the ABC transporter superfamily
ITG13_08965	COG1227	inorganic diphosphatase activity
ITG13_08975	COG0243	molybdopterin cofactor binding
ITG13_08980	COG3005	denitrification pathway
ITG13_08985	COG4459	periplasmic nitrate reductase
ITG13_08990	COG0390	transport system, permease component
ITG13_08995	COG2116	formate transmembrane transporter activity
ITG13_09025	COG0215	cysteine-tRNA ligase activity
ITG13_09030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG13_09035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG13_09040	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG13_09045	COG3012	SEC-C Motif Domain Protein
ITG13_09050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ITG13_09050	COG0140	phosphoribosyl-ATP diphosphatase activity
ITG13_09055	COG0107	imidazoleglycerol-phosphate synthase activity
ITG13_09060	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ITG13_09065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ITG13_09070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG13_09070	COG0131	Imidazoleglycerol-phosphate dehydratase
ITG13_09075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG13_09090	COG1757	Na H antiporter
ITG13_09095	COG2916	Histone family protein nucleoid-structuring protein H-NS
ITG13_09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG13_09115	COG2915	High frequency lysogenization protein hflD homolog
ITG13_09120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ITG13_09125	COG0501	Belongs to the peptidase M48B family
ITG13_09135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ITG13_09140	COG2226	methyltransferase
ITG13_09145	COG0156	8-amino-7-oxononanoate synthase activity
ITG13_09150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ITG13_09155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITG13_09160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_09160	COG2205	protein histidine kinase activity
ITG13_09170	COG0745	RESPONSE REGULATOR receiver
ITG13_09175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ITG13_09180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ITG13_09185	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ITG13_09190	COG1674	ftsk spoiiie
ITG13_09195	COG1522	sequence-specific DNA binding
ITG13_09200	COG0686	Belongs to the AlaDH PNT family
ITG13_09210	COG0583	DNA-binding transcription factor activity
ITG13_09225	COG0284	orotidine-5'-phosphate decarboxylase activity
ITG13_09230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ITG13_09235	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ITG13_09240	COG0776	regulation of translation
ITG13_09245	COG0539	negative regulation of cytoplasmic translation
ITG13_09250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ITG13_09255	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ITG13_09260	COG2835	tetraacyldisaccharide 4'-kinase activity
ITG13_09265	COG1663	tetraacyldisaccharide 4'-kinase activity
ITG13_09270	COG1132	(ABC) transporter
ITG13_09275	COG2333	competence protein COMEC
ITG13_09275	COG0658	competence protein
ITG13_09285	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG13_09290	COG1136	(ABC) transporter
ITG13_09295	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG13_09305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ITG13_09320	COG1252	NADH dehydrogenase
ITG13_09325	COG3150	esterase
ITG13_09350	COG0537	adenosine 5'-monophosphoramidase activity
ITG13_09380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ITG13_09380	COG0617	tRNA 3'-terminal CCA addition
ITG13_09380	COG0517	IMP dehydrogenase activity
ITG13_09405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG13_09430	COG0697	spore germination
ITG13_09435	COG1902	pentaerythritol trinitrate reductase activity
ITG13_09440	COG0346	lactoylglutathione lyase activity
ITG13_09445	COG0583	DNA-binding transcription factor activity
ITG13_09470	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG13_09495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITG13_09500	COG1845	cytochrome c oxidase, subunit III
ITG13_09505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG13_09510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG13_09515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG13_09525	COG1309	transcriptional regulator
ITG13_09530	COG0583	DNA-binding transcription factor activity
ITG13_09545	COG3040	lipid binding
ITG13_09560	COG1228	amidohydrolase
ITG13_09590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG13_09600	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG13_09645	COG3153	acetyltransferase
ITG13_09655	COG1227	inorganic diphosphatase activity
ITG13_09660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG13_09665	COG2233	PERMEase
ITG13_09685	COG1280	lysine exporter protein (LysE YggA)
ITG13_09690	COG1522	sequence-specific DNA binding
ITG13_09695	COG1760	l-serine dehydratase
ITG13_09720	COG1609	Transcriptional regulator
ITG13_09725	COG3119	arylsulfatase activity
ITG13_09755	COG0583	DNA-binding transcription factor activity
ITG13_09760	COG1486	melibiose metabolic process
ITG13_09765	COG3394	polysaccharide catabolic process
ITG13_09770	COG0789	Transcriptional regulator
ITG13_09785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG13_09815	COG0463	Glycosyl transferase, family 2
ITG13_09815	COG1216	Glycosyl transferase, family 2
ITG13_09820	COG0438	transferase activity, transferring glycosyl groups
ITG13_09825	COG0328	RNA-DNA hybrid ribonuclease activity
ITG13_09825	COG3341	Caulimovirus viroplasmin
ITG13_09870	COG0583	DNA-binding transcription factor activity
ITG13_09905	COG0583	DNA-binding transcription factor activity
ITG13_09915	COG4124	Belongs to the glycosyl hydrolase 26 family
ITG13_09915	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ITG13_09935	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ITG13_09940	COG1946	Acyl-CoA thioesterase
ITG13_09950	COG1522	sequence-specific DNA binding
ITG13_09960	COG1902	pentaerythritol trinitrate reductase activity
ITG13_10000	COG1309	transcriptional regulator
ITG13_10010	COG0641	radical SAM
ITG13_10040	COG1454	alcohol dehydrogenase
ITG13_10050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG13_10110	COG2855	membrane
ITG13_10130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ITG13_10135	COG2267	carboxylic ester hydrolase activity
ITG13_10140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ITG13_10145	COG1169	isochorismate synthase
ITG13_10150	COG0436	Aminotransferase
ITG13_10155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ITG13_10160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ITG13_10175	COG1555	photosystem II stabilization
ITG13_10180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG13_10185	COG0776	regulation of translation
ITG13_10190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ITG13_10195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ITG13_10200	COG0740	serine-type endopeptidase activity
ITG13_10205	COG0544	peptidyl-prolyl cis-trans isomerase activity
ITG13_10220	COG2204	response regulator
ITG13_10230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG13_10235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG13_10240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG13_10255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG13_10255	COG3321	synthase
ITG13_10270	COG2070	2-Nitropropane dioxygenase
ITG13_10270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ITG13_10275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG13_10280	COG3842	ATPase activity
ITG13_10290	COG1175	transmembrane transport
ITG13_10310	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ITG13_10315	COG1280	lysine exporter protein (LysE YggA)
ITG13_10320	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG13_10325	COG2840	Smr protein MutS2
ITG13_10330	COG2062	phosphohistidine phosphatase, SixA
ITG13_10340	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG13_10340	COG1024	Enoyl-CoA hydratase
ITG13_10345	COG0183	Belongs to the thiolase family
ITG13_10365	COG2067	long-chain fatty acid transport protein
ITG13_10370	COG2853	Lipoprotein
ITG13_10375	COG3088	subunit of a heme lyase
ITG13_10375	COG4235	cytochrome complex assembly
ITG13_10380	COG3088	subunit of a heme lyase
ITG13_10380	COG4235	cytochrome complex assembly
ITG13_10385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITG13_10390	COG1138	Cytochrome C-type biogenesis protein
ITG13_10395	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ITG13_10400	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG13_10405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG13_10410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG13_10415	COG4133	protoheme IX ABC transporter activity
ITG13_10425	COG0835	chemotaxis
ITG13_10435	COG1192	Involved in chromosome partitioning
ITG13_10440	COG2201	protein-glutamate methylesterase activity
ITG13_10445	COG0784	Response regulator, receiver
ITG13_10445	COG2198	Histidine kinase
ITG13_10445	COG0643	Histidine kinase
ITG13_10450	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ITG13_10485	COG1684	flagellar biosynthetic protein fliR
ITG13_10490	COG1987	bacterial-type flagellum assembly
ITG13_10540	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITG13_10550	COG1677	Flagellar hook-basal body complex protein FliE
ITG13_10570	COG1516	flagellar protein fliS
ITG13_10580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG13_10585	COG1334	flagellar protein FlaG
ITG13_10590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG13_10595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG13_10615	COG1705	Flagellar rod assembly protein muramidase FlgJ
ITG13_10615	COG3951	Flagellar rod assembly protein muramidase FlgJ
ITG13_10620	COG1706	bacterial-type flagellum-dependent cell motility
ITG13_10625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG13_10635	COG4787	bacterial-type flagellum-dependent cell motility
ITG13_10640	COG1749	Flagellar hook protein flgE
ITG13_10650	COG1558	bacterial-type flagellum-dependent cell motility
ITG13_10655	COG1815	bacterial-type flagellum-dependent cell motility
ITG13_10660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ITG13_10665	COG0835	chemotaxis
ITG13_10665	COG0784	Response regulator, receiver
ITG13_10670	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ITG13_10730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG13_10735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG13_10755	COG1216	Glycosyl transferase, family 2
ITG13_10760	COG2986	histidine ammonia-lyase
ITG13_10795	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_10810	COG2608	mercury ion transmembrane transporter activity
ITG13_10810	COG2217	Heavy metal translocating P-type atpase
ITG13_10850	COG2840	Smr protein MutS2
ITG13_10855	COG1187	pseudouridine synthase activity
ITG13_10860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ITG13_10870	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ITG13_10875	COG2912	Transglutaminase-like superfamily
ITG13_10880	COG3094	Invasion gene expression up-regulator, SirB
ITG13_10885	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG13_10890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ITG13_10895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ITG13_10900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ITG13_10905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ITG13_10910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ITG13_10915	COG0193	aminoacyl-tRNA hydrolase activity
ITG13_11020	COG2706	6-phosphogluconolactonase activity
ITG13_11025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG13_11035	COG1702	phosphate starvation-inducible protein PhoH
ITG13_11040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ITG13_11045	COG4535	Mg2 and Co2 transporter CorC
ITG13_11050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ITG13_11055	COG2888	peptidyl-tyrosine sulfation
ITG13_11060	COG0495	leucyl-tRNA aminoacylation
ITG13_11065	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ITG13_11070	COG1466	dna polymerase III delta subunit
ITG13_11075	COG0799	negative regulation of ribosome biogenesis
ITG13_11080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ITG13_11085	COG0768	penicillin binding
ITG13_11090	COG0772	Belongs to the SEDS family
ITG13_11095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG13_11100	COG1686	Belongs to the peptidase S11 family
ITG13_11110	COG0321	lipoyl(octanoyl) transferase activity
ITG13_11115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ITG13_11120	COG0733	neurotransmitter:sodium symporter activity
ITG13_11135	COG0514	ATP-dependent DNA helicase (RecQ)
ITG13_11140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG13_11150	COG2991	Protein conserved in bacteria
ITG13_11155	COG1477	protein flavinylation
ITG13_11160	COG2871	sodium ion transport
ITG13_11165	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG13_11170	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG13_11180	COG1805	sodium ion transport
ITG13_11185	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG13_11190	COG0271	Belongs to the BolA IbaG family
ITG13_11195	COG2813	Specifically methylates the guanine in position
ITG13_11205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG13_11220	COG3248	Nucleoside-binding outer membrane protein
ITG13_11225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITG13_11230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG13_11235	COG2166	iron-sulfur cluster assembly
ITG13_11240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ITG13_11245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ITG13_11255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ITG13_11255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG13_11265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG13_11270	COG1074	ATP-dependent DNA helicase activity
ITG13_11280	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ITG13_11295	COG3141	response to X-ray
ITG13_11310	COG2095	MarC family integral membrane protein
ITG13_11315	COG0737	Belongs to the 5'-nucleotidase family
ITG13_11320	COG2171	N-acyltransferase activity
ITG13_11330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITG13_11330	COG0047	phosphoribosylformylglycinamidine synthase activity
ITG13_11345	COG1253	flavin adenine dinucleotide binding
ITG13_11350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG13_11380	COG0484	heat shock protein binding
ITG13_11385	COG0443	Heat shock 70 kDa protein
ITG13_11400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ITG13_11405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ITG13_11410	COG0497	DNA recombination
ITG13_11415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG13_11420	COG2914	Belongs to the UPF0125 (RnfH) family
ITG13_11425	COG2867	negative regulation of translational initiation
ITG13_11440	COG0189	ligase activity
ITG13_11440	COG4067	protein conserved in archaea
ITG13_11465	COG0204	Acyl-transferase
ITG13_11470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ITG13_11475	COG1115	amino acid carrier protein
ITG13_11480	COG1584	GPR1 FUN34 yaaH family protein
ITG13_11485	COG1757	Na H antiporter
ITG13_11495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ITG13_11495	COG0519	Catalyzes the synthesis of GMP from XMP
ITG13_11500	COG0517	IMP dehydrogenase activity
ITG13_11500	COG0516	GMP reductase activity
ITG13_11505	COG1570	exodeoxyribonuclease VII activity
ITG13_11510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ITG13_11525	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ITG13_11530	COG0804	urea catabolic process
ITG13_11535	COG0832	Belongs to the urease beta subunit family
ITG13_11540	COG0831	urea catabolic process
ITG13_11580	COG3706	GGDEF domain
ITG13_11590	COG1160	GTP binding
ITG13_11595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG13_11600	COG2976	Protein conserved in bacteria
ITG13_11605	COG0124	histidyl-tRNA synthetase
ITG13_11610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ITG13_11615	COG1426	Protein conserved in bacteria
ITG13_11620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ITG13_11625	COG0105	UTP biosynthetic process
ITG13_11630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG13_11635	COG2975	iron-sulfur cluster assembly
ITG13_11645	COG0443	Heat shock 70 kDa protein
ITG13_11650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG13_11660	COG0822	iron-sulfur transferase activity
ITG13_11665	COG1104	cysteine desulfurase activity
ITG13_11670	COG1959	2 iron, 2 sulfur cluster binding
ITG13_11675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ITG13_11680	COG0483	inositol monophosphate 1-phosphatase activity
ITG13_11685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG13_11690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG13_11695	COG1862	Preprotein translocase
ITG13_11700	COG0343	queuine tRNA-ribosyltransferase activity
ITG13_11705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ITG13_11710	COG0517	IMP dehydrogenase activity
ITG13_11715	COG0583	DNA-binding transcription factor activity
ITG13_11720	COG0450	alkyl hydroperoxide reductase
ITG13_11725	COG3142	Participates in the control of copper homeostasis
ITG13_11745	COG0704	Plays a role in the regulation of phosphate uptake
ITG13_11750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG13_11755	COG0581	inorganic phosphate transmembrane transporter activity
ITG13_11765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ITG13_11770	COG0248	Ppx GppA phosphatase
ITG13_11780	COG5002	protein histidine kinase activity
ITG13_11785	COG0745	RESPONSE REGULATOR receiver
ITG13_11790	COG2974	May be involved in recombination
ITG13_11795	COG0826	peptidase U32
ITG13_11800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG13_11810	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ITG13_11855	COG0564	pseudouridine synthase activity
ITG13_11860	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG13_11865	COG0741	lytic transglycosylase activity
ITG13_11870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG13_11875	COG0077	Prephenate dehydratase
ITG13_11875	COG1605	Chorismate mutase
ITG13_11880	COG5001	Diguanylate cyclase
ITG13_11885	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ITG13_11890	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ITG13_11900	COG0488	(ABC) transporter
ITG13_11910	COG0739	heme binding
ITG13_11915	COG1605	Chorismate mutase
ITG13_11915	COG0287	Prephenate dehydrogenase
ITG13_11920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG13_11930	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ITG13_11935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ITG13_11945	COG1966	Carbon starvation protein
ITG13_11950	COG3385	transposase activity
ITG13_11955	COG3275	phosphorelay sensor kinase activity
ITG13_11960	COG3279	Response regulator of the LytR AlgR family
ITG13_11965	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ITG13_11970	COG1047	Peptidyl-prolyl cis-trans
ITG13_11980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG13_11985	COG0196	riboflavin kinase activity
ITG13_11990	COG0728	peptidoglycan biosynthetic process
ITG13_11995	COG0268	Binds directly to 16S ribosomal RNA
ITG13_12000	COG0640	Transcriptional regulator
ITG13_12005	COG0583	DNA-binding transcription factor activity
ITG13_12010	COG1283	sodium-dependent phosphate transmembrane transporter activity
ITG13_12015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ITG13_12020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ITG13_12025	COG0730	response to heat
ITG13_12035	COG0494	nUDIX hydrolase
ITG13_12055	COG2204	response regulator
ITG13_12070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITG13_12075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG13_12080	COG4974	Belongs to the 'phage' integrase family
ITG13_12085	COG0716	FMN binding
ITG13_12095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ITG13_12100	COG0513	Belongs to the DEAD box helicase family
ITG13_12105	COG3022	response to hydroperoxide
ITG13_12110	COG1115	amino acid carrier protein
ITG13_12125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ITG13_12130	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ITG13_12135	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ITG13_12140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ITG13_12145	COG0083	homoserine kinase activity
ITG13_12160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG13_12170	COG0745	RESPONSE REGULATOR receiver
ITG13_12180	COG0784	Response regulator, receiver
ITG13_12180	COG2198	Histidine kinase
ITG13_12180	COG5002	protein histidine kinase activity
ITG13_12185	COG5001	Diguanylate cyclase
ITG13_12185	COG2203	Gaf domain
ITG13_12185	COG3706	GGDEF domain
ITG13_12185	COG4251	negative regulation of phosphorylation
ITG13_12190	COG1242	4 iron, 4 sulfur cluster binding
ITG13_12195	COG0067	glutamate synthase
ITG13_12195	COG0069	glutamate synthase activity
ITG13_12195	COG0070	glutamate synthase
ITG13_12205	COG0067	glutamate synthase
ITG13_12205	COG0069	glutamate synthase activity
ITG13_12205	COG0070	glutamate synthase
ITG13_12210	COG0493	'glutamate synthase
ITG13_12220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG13_12235	COG2860	membrane
ITG13_12240	COG0583	DNA-binding transcription factor activity
ITG13_12245	COG0730	response to heat
ITG13_12250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITG13_12255	COG0505	Belongs to the CarA family
ITG13_12260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ITG13_12265	COG0494	nUDIX hydrolase
ITG13_12270	COG0653	protein targeting
ITG13_12275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ITG13_12280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ITG13_12285	COG0849	cell division
ITG13_12290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ITG13_12295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG13_12300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ITG13_12305	COG0772	Belongs to the SEDS family
ITG13_12310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ITG13_12315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG13_12320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ITG13_12325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG13_12330	COG0768	penicillin binding
ITG13_12335	COG3116	cell division
ITG13_12340	COG0275	rRNA processing
ITG13_12350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ITG13_12365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG13_12370	COG2823	Periplasmic or secreted lipoprotein
ITG13_12375	COG2969	positive regulation of protein catabolic process
ITG13_12380	COG0625	glutathione transferase activity
ITG13_12385	COG2857	Cytochrome c1
ITG13_12390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITG13_12395	COG0723	plastoquinol--plastocyanin reductase activity
ITG13_12400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ITG13_12405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ITG13_12410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ITG13_12415	COG3105	Protein conserved in bacteria
ITG13_12420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG13_12425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG13_12440	COG3150	esterase
ITG13_12450	COG3151	Protein conserved in bacteria
ITG13_12455	COG0494	nUDIX hydrolase
ITG13_12460	COG1538	Outer membrane efflux protein
ITG13_12465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ITG13_12465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ITG13_12470	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ITG13_12480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG13_12485	COG3025	triphosphatase activity
ITG13_12490	COG1392	Phosphate transport regulator
ITG13_12495	COG0306	phosphate transporter
ITG13_12500	COG4991	sh3 domain protein
ITG13_12510	COG3409	Peptidoglycan-binding domain 1 protein
ITG13_12510	COG3267	Type II secretory pathway component ExeA
ITG13_12515	COG0617	tRNA 3'-terminal CCA addition
ITG13_12520	COG1968	undecaprenyl-diphosphatase activity
ITG13_12525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG13_12530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG13_12535	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ITG13_12540	COG0596	Alpha beta hydrolase
ITG13_12545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ITG13_12550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ITG13_12555	COG1610	YqeY-like protein
ITG13_12575	COG2873	o-acetylhomoserine
ITG13_12580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ITG13_12585	COG1349	DNA-binding transcription factor activity
ITG13_12590	COG0469	pyruvate kinase activity
ITG13_12600	COG3706	GGDEF domain
ITG13_12610	COG0028	Belongs to the TPP enzyme family
ITG13_12615	COG1022	Amp-dependent synthetase and ligase
ITG13_12650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITG13_12655	COG0473	3-isopropylmalate dehydrogenase activity
ITG13_12665	COG0066	3-isopropylmalate dehydratase activity
ITG13_12680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG13_12685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ITG13_12690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG13_12695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ITG13_12700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ITG13_12705	COG2967	ApaG domain
ITG13_12720	COG3610	response to peptide
ITG13_12725	COG2966	Psort location CytoplasmicMembrane, score
ITG13_12730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ITG13_12735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ITG13_12740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ITG13_12745	COG0142	geranyltranstransferase activity
ITG13_12755	COG0039	L-malate dehydrogenase activity
ITG13_12760	COG1438	arginine binding
ITG13_12775	COG0589	response to stress
ITG13_12780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG13_12795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITG13_12800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ITG13_12805	COG0312	modulator of DNA gyrase
ITG13_12810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITG13_12825	COG0424	maF-like protein
ITG13_12830	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ITG13_12835	COG1792	Involved in formation and maintenance of cell shape
ITG13_12840	COG1077	Cell shape determining protein MreB Mrl
ITG13_12870	COG2165	general secretion pathway protein
ITG13_12875	COG2165	general secretion pathway protein
ITG13_12885	COG1459	type II secretion system
ITG13_12890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG13_12900	COG3409	Peptidoglycan-binding domain 1 protein
ITG13_12900	COG3267	Type II secretory pathway component ExeA
ITG13_12925	COG2200	EAL domain
ITG13_12925	COG2199	diguanylate cyclase activity
ITG13_12930	COG0629	single-stranded DNA binding
ITG13_12935	COG2197	response regulator
ITG13_12945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ITG13_12955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITG13_12960	COG0527	aspartate kinase activity
ITG13_13030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ITG13_13040	COG4206	TonB-dependent receptor
ITG13_13045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG13_13060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG13_13065	COG0534	Mate efflux family protein
ITG13_13070	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ITG13_13075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ITG13_13080	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG13_13085	COG2937	Belongs to the GPAT DAPAT family
ITG13_13090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ITG13_13095	COG3161	chorismate lyase activity
ITG13_13100	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG13_13105	COG0705	Rhomboid family
ITG13_13110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG13_13120	COG2177	Part of the ABC transporter FtsEX involved in
ITG13_13125	COG2884	Cell division ATP-binding protein ftsE
ITG13_13130	COG0552	protein localization to endoplasmic reticulum
ITG13_13135	COG0742	ribosomal rna small subunit methyltransferase
ITG13_13145	COG2095	MarC family integral membrane protein
ITG13_13185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG13_13190	COG0640	Transcriptional regulator
ITG13_13195	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG13_13200	COG1280	lysine exporter protein (LysE YggA)
ITG13_13205	COG2267	carboxylic ester hydrolase activity
ITG13_13210	COG0561	phosphatase activity
ITG13_13225	COG3148	PFAM DTW domain containing protein
ITG13_13230	COG2200	EAL domain
ITG13_13230	COG2199	diguanylate cyclase activity
ITG13_13230	COG3287	FIST C domain
ITG13_13235	COG2199	diguanylate cyclase activity
ITG13_13235	COG2200	EAL domain
ITG13_13235	COG3287	FIST C domain
ITG13_13240	COG1011	Hydrolase
ITG13_13245	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ITG13_13255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ITG13_13260	COG0019	diaminopimelate decarboxylase activity
ITG13_13270	COG1965	Belongs to the frataxin family
ITG13_13275	COG3072	Adenylate cyclase
ITG13_13280	COG0181	hydroxymethylbilane synthase activity
ITG13_13285	COG1587	Uroporphyrinogen-III synthase
ITG13_13290	COG2959	enzyme of heme biosynthesis
ITG13_13295	COG3071	HemY protein
ITG13_13350	COG2871	sodium ion transport
ITG13_13355	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ITG13_13370	COG3118	belongs to the thioredoxin family
ITG13_13375	COG0513	Belongs to the DEAD box helicase family
ITG13_13380	COG0248	Ppx GppA phosphatase
ITG13_13385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ITG13_13395	COG0514	ATP-dependent DNA helicase (RecQ)
ITG13_13400	COG2962	Rard protein
ITG13_13420	COG1280	lysine exporter protein (LysE YggA)
ITG13_13425	COG0405	Gamma-glutamyltransferase
ITG13_13435	COG0210	DNA helicase
ITG13_13445	COG3220	belongs to the UPF0276 family
ITG13_13475	COG0006	proline dipeptidase activity
ITG13_13475	COG0006	proline dipeptidase activity
ITG13_13485	COG2022	thiamine diphosphate biosynthetic process
ITG13_13490	COG2104	thiamine diphosphate biosynthetic process
ITG13_13495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG13_13500	COG0352	thiamine-phosphate diphosphorylase activity
ITG13_13505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ITG13_13560	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ITG13_13565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG13_13570	COG1739	Uncharacterized protein family UPF0029
ITG13_13575	COG1024	Enoyl-CoA hydratase
ITG13_13575	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG13_13580	COG0183	Belongs to the thiolase family
ITG13_13585	COG0604	alcohol dehydrogenase
ITG13_13600	COG0425	Belongs to the sulfur carrier protein TusA family
ITG13_13610	COG2119	membrane
ITG13_13615	COG0752	glycyl-tRNA synthetase alpha subunit
ITG13_13620	COG0751	glycine-tRNA ligase activity
ITG13_13625	COG0366	Alpha amylase catalytic
ITG13_13630	COG3977	Valine--pyruvate aminotransferase
ITG13_13640	COG0187	DNA topoisomerase II activity
ITG13_13645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITG13_13650	COG0592	DNA-directed DNA polymerase activity
ITG13_13655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ITG13_13670	COG1126	abc transporter atp-binding protein
ITG13_13675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ITG13_13680	COG0594	ribonuclease P activity
ITG13_13685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ITG13_13690	COG0706	membrane insertase activity
ITG13_13700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG13_13705	COG0445	tRNA wobble uridine modification
ITG13_13710	COG0357	Ribosomal RNA small subunit methyltransferase G
ITG13_13715	COG1192	Involved in chromosome partitioning
ITG13_13720	COG1475	DNA binding
ITG13_13725	COG3312	ion transport
ITG13_13740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ITG13_13745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG13_13750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ITG13_13755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG13_13760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ITG13_13765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG13_13775	COG2814	Major facilitator Superfamily
ITG13_13780	COG0583	DNA-binding transcription factor activity
ITG13_13790	COG0129	dihydroxy-acid dehydratase activity
ITG13_13795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG13_13800	COG3978	acetolactate synthase activity
ITG13_13810	COG0606	chelatase, subunit chli
ITG13_13820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG13_13825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITG13_13835	COG3084	Protein conserved in bacteria
ITG13_13845	COG4326	sporulation control protein
ITG13_13850	COG1272	protein, Hemolysin III
ITG13_13860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG13_13865	COG0569	domain protein
ITG13_13870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG13_13870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG13_13875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ITG13_13880	COG0242	peptide deformylase activity
ITG13_13890	COG0758	DNA mediated transformation
ITG13_13895	COG2922	Belongs to the Smg family
ITG13_13900	COG0551	DNA topoisomerase type I activity
ITG13_13905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ITG13_13910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ITG13_13915	COG0009	L-threonylcarbamoyladenylate synthase
ITG13_13920	COG0408	coproporphyrinogen oxidase activity
ITG13_13925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ITG13_13935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG13_13980	COG0583	DNA-binding transcription factor activity
ITG13_13985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ITG13_13990	COG2960	long-chain fatty acid transporting porin activity
ITG13_13995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG13_14000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_14005	COG1309	transcriptional regulator
ITG13_14055	COG0601	transmembrane transport
ITG13_14060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG13_14105	COG1805	sodium ion transport
ITG13_14115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG13_14120	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ITG13_14125	COG0339	signal peptide processing
ITG13_14130	COG1522	sequence-specific DNA binding
ITG13_14135	COG5001	Diguanylate cyclase
ITG13_14135	COG5002	protein histidine kinase activity
ITG13_14140	COG0742	ribosomal rna small subunit methyltransferase
ITG13_14155	COG0589	response to stress
ITG13_14160	COG1528	Iron-storage protein
ITG13_14170	COG2081	HI0933 family
ITG13_14180	COG1322	Protein conserved in bacteria
ITG13_14185	COG2226	methyltransferase
ITG13_14190	COG3165	ubiquinone biosynthetic process from chorismate
ITG13_14195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG13_14200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG13_14205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG13_14210	COG0805	protein transport
ITG13_14215	COG0084	hydrolase, TatD family'
ITG13_14230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG13_14230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG13_14255	COG3078	GTPase activator activity
ITG13_14280	COG3852	Histidine kinase
ITG13_14290	COG0174	glutamine synthetase
ITG13_14295	COG1217	gtp-binding protein TYPA
ITG13_14310	COG1295	ribonuclease BN
ITG13_14315	COG1490	D-aminoacyl-tRNA deacylase activity
ITG13_14320	COG0456	acetyltransferase
ITG13_14330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ITG13_14340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ITG13_14345	COG3031	protein transport across the cell outer membrane
ITG13_14355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG13_14360	COG1459	type II secretion system
ITG13_14365	COG2165	general secretion pathway protein
ITG13_14370	COG2165	general secretion pathway protein
ITG13_14375	COG2165	general secretion pathway protein
ITG13_14380	COG4795	General secretion pathway protein
ITG13_14385	COG3156	type II secretion system protein K
ITG13_14390	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG13_14395	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG13_14405	COG1218	3'(2'),5'-bisphosphate nucleotidase
ITG13_14410	COG0494	nUDIX hydrolase
ITG13_14415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ITG13_14415	COG0316	Belongs to the HesB IscA family
ITG13_14420	COG1040	competence protein
ITG13_14425	COG0596	Alpha beta hydrolase
ITG13_14435	COG2183	response to ionizing radiation
ITG13_14440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG13_14455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ITG13_14460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG13_14465	COG1758	RNA polymerase activity
ITG13_14470	COG0194	GDP metabolic process
ITG13_14475	COG2252	PERMEase
ITG13_14485	COG1278	Cold shock
ITG13_14490	COG1561	YicC-like family, N-terminal region
ITG13_14495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ITG13_14500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ITG13_14505	COG1560	Kdo2-lipid A biosynthetic process
ITG13_14510	COG1309	transcriptional regulator
ITG13_14520	COG2003	Belongs to the UPF0758 family
ITG13_14525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ITG13_14530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ITG13_14540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ITG13_14570	COG0463	Glycosyl transferase, family 2
ITG13_14575	COG0859	PFAM glycosyl transferase family 9
ITG13_14580	COG3642	lipopolysaccharide core region biosynthetic process
ITG13_14590	COG0438	transferase activity, transferring glycosyl groups
ITG13_14590	COG0297	glycogen (starch) synthase activity
ITG13_14600	COG2089	acid synthase
ITG13_14615	COG1519	Transferase
ITG13_14620	COG0859	PFAM glycosyl transferase family 9
ITG13_14625	COG1560	Kdo2-lipid A biosynthetic process
ITG13_14645	COG4942	peptidase
ITG13_14650	COG1045	serine acetyltransferase
ITG13_14660	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ITG13_14665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG13_14685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG13_14690	COG1596	polysaccharide export
ITG13_14790	COG0463	Glycosyl transferase, family 2
ITG13_14825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG13_14830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ITG13_14840	COG0534	Mate efflux family protein
ITG13_14865	COG2199	diguanylate cyclase activity
ITG13_14865	COG2203	Gaf domain
ITG13_14870	COG1285	pathogenesis
ITG13_14875	COG1509	lysine 2,3-aminomutase activity
ITG13_14880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG13_14890	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ITG13_14895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG13_14900	COG1053	succinate dehydrogenase
ITG13_14905	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ITG13_14915	COG0490	domain, Protein
ITG13_14915	COG0471	metal ion transport
ITG13_14920	COG0688	phosphatidylethanolamine metabolic process
ITG13_14925	COG1162	GTPase activity
ITG13_15015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ITG13_15020	COG0802	atpase or kinase
ITG13_15025	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITG13_15030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ITG13_15035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ITG13_15040	COG1923	regulation of RNA biosynthetic process
ITG13_15045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG13_15050	COG0330	HflC and HflK could
ITG13_15055	COG0330	HflC and HflK could
ITG13_15060	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ITG13_15065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG13_15070	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ITG13_15075	COG0402	S-adenosylhomocysteine deaminase activity
ITG13_15080	COG0557	exoribonuclease II activity
ITG13_15085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG13_15090	COG0360	Binds together with S18 to 16S ribosomal RNA
ITG13_15100	COG0359	binds to the 23S rRNA
ITG13_15115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITG13_15125	COG0432	Pfam Uncharacterised protein family UPF0047
ITG13_15130	COG0166	Belongs to the GPI family
ITG13_15140	COG0735	belongs to the Fur family
ITG13_15290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG13_15295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG13_15300	COG0175	sulfate reduction
ITG13_15380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG13_15380	COG0646	methionine synthase
ITG13_15405	COG0604	alcohol dehydrogenase
ITG13_15405	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_15405	COG3321	synthase
ITG13_15415	COG2814	Major facilitator Superfamily
ITG13_15420	COG2207	Transcriptional regulator
ITG13_15435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG13_15455	COG2207	Transcriptional regulator
ITG13_15470	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ITG13_15470	COG3408	Glycogen debranching enzyme
ITG13_15475	COG2169	Transcriptional regulator
ITG13_15480	COG1486	melibiose metabolic process
ITG13_15485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITG13_15515	COG1846	Transcriptional regulator
ITG13_15540	COG1012	belongs to the aldehyde dehydrogenase family
ITG13_15545	COG1309	transcriptional regulator
ITG13_15555	COG0745	RESPONSE REGULATOR receiver
ITG13_15560	COG2205	protein histidine kinase activity
ITG13_15580	COG0579	oxidoreductase
ITG13_15595	COG2204	response regulator
ITG13_15610	COG0800	Aldolase
ITG13_15615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG13_15620	COG4145	pantothenate transmembrane transporter activity
ITG13_15630	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ITG13_15655	COG2194	sulfuric ester hydrolase activity
ITG13_15680	COG1132	(ABC) transporter
ITG13_15715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_15740	COG0259	pyridoxamine-phosphate oxidase activity
ITG13_15780	COG1444	tRNA N-acetyltransferase activity
ITG13_15805	COG4608	Belongs to the ABC transporter superfamily
ITG13_15810	COG0444	Belongs to the ABC transporter superfamily
ITG13_15820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG13_15820	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ITG13_15835	COG4221	oxidoreductase activity
ITG13_15850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG13_15865	COG0765	amino acid transport
ITG13_15900	COG3842	ATPase activity
ITG13_15910	COG0745	RESPONSE REGULATOR receiver
ITG13_15915	COG2205	protein histidine kinase activity
ITG13_15935	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ITG13_15945	COG0625	glutathione transferase activity
ITG13_15965	COG0604	alcohol dehydrogenase
ITG13_15965	COG3321	synthase
ITG13_15970	COG0583	DNA-binding transcription factor activity
ITG13_15975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG13_15980	COG3186	Phenylalanine-4-hydroxylase
ITG13_16005	COG0217	transcriptional regulatory protein
ITG13_16020	COG2084	Dehydrogenase
ITG13_16035	COG0583	DNA-binding transcription factor activity
ITG13_16050	COG1136	(ABC) transporter
ITG13_16055	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG13_16070	COG3275	phosphorelay sensor kinase activity
ITG13_16075	COG3279	Response regulator of the LytR AlgR family
ITG13_16080	COG0612	Peptidase, M16
ITG13_16090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG13_16095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG13_16110	COG1902	pentaerythritol trinitrate reductase activity
ITG13_16115	COG2814	Major facilitator Superfamily
ITG13_16120	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_16140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG13_16150	COG0724	RNA recognition motif
ITG13_16175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG13_16200	COG0415	Belongs to the DNA photolyase family
ITG13_16210	COG3806	Anti-sigma factor
ITG13_16215	COG1595	DNA-templated transcription, initiation
ITG13_16225	COG1942	4-Oxalocrotonate Tautomerase
ITG13_16240	COG0786	glutamate:sodium symporter activity
ITG13_16245	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG13_16265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_16265	COG2213	PTS system mannitol-specific
ITG13_16270	COG0246	Mannitol dehydrogenase
ITG13_16275	COG3722	fumarate hydratase activity
ITG13_16280	COG0363	glucosamine-6-phosphate deaminase activity
ITG13_16300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITG13_16310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ITG13_16320	COG3366	ferrous iron transmembrane transporter activity
ITG13_16325	COG0700	Nucleoside recognition
ITG13_16330	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ITG13_16375	COG0596	Alpha beta hydrolase
ITG13_16390	COG3123	guanosine phosphorylase activity
ITG13_16395	COG1741	Belongs to the pirin family
ITG13_16425	COG2197	response regulator
ITG13_16430	COG3851	Histidine kinase
ITG13_16435	COG2271	Major facilitator Superfamily
ITG13_16440	COG1482	cell wall glycoprotein biosynthetic process
ITG13_16455	COG0745	RESPONSE REGULATOR receiver
ITG13_16470	COG1054	Belongs to the UPF0176 family
ITG13_16475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG13_16480	COG2207	Transcriptional regulator
ITG13_16480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG13_16485	COG0534	Mate efflux family protein
ITG13_16495	COG4172	Belongs to the ABC transporter superfamily
ITG13_16500	COG0747	negative chemotaxis
ITG13_16520	COG1304	FMN binding
ITG13_16525	COG1620	l-lactate permease
ITG13_16530	COG0583	DNA-binding transcription factor activity
ITG13_16535	COG1505	serine-type exopeptidase activity
ITG13_16565	COG0395	ABC-type sugar transport system, permease component
ITG13_16570	COG2723	6-phospho-beta-galactosidase activity
ITG13_16575	COG3842	ATPase activity
ITG13_16580	COG3459	Glycosyltransferase 36 associated
ITG13_16595	COG1609	Transcriptional regulator
ITG13_16600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG13_16605	COG1482	cell wall glycoprotein biosynthetic process
ITG13_16610	COG0246	Mannitol dehydrogenase
ITG13_16615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_16620	COG1312	Catalyzes the dehydration of D-mannonate
ITG13_16625	COG0110	maltose O-acetyltransferase activity
ITG13_16635	COG2186	Transcriptional regulator
ITG13_16640	COG4172	Belongs to the ABC transporter superfamily
ITG13_16650	COG1067	ATP-dependent peptidase activity
ITG13_16695	COG1846	Transcriptional regulator
ITG13_16705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ITG13_16710	COG3960	tartronate-semialdehyde synthase activity
ITG13_16715	COG3622	Belongs to the hyi family
ITG13_16720	COG2084	Dehydrogenase
ITG13_16735	COG0402	S-adenosylhomocysteine deaminase activity
ITG13_16750	COG2252	PERMEase
ITG13_16770	COG4266	Belongs to the allantoicase family
ITG13_16775	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ITG13_16800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ITG13_16820	COG0789	Transcriptional regulator
ITG13_16825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ITG13_16835	COG0402	S-adenosylhomocysteine deaminase activity
ITG13_16845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ITG13_16870	COG1418	mRNA catabolic process
ITG13_16875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG13_16880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG13_16925	COG0583	DNA-binding transcription factor activity
ITG13_16935	COG3655	Transcriptional regulator
ITG13_16960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG13_16965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ITG13_16970	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ITG13_16995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG13_17000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_17005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_17010	COG1136	(ABC) transporter
ITG13_17010	COG0577	efflux transmembrane transporter activity
ITG13_17015	COG2205	protein histidine kinase activity
ITG13_17020	COG0745	RESPONSE REGULATOR receiver
ITG13_17030	COG1882	Formate acetyltransferase
ITG13_17050	COG4303	Ethanolamine ammonia lyase large subunit
ITG13_17060	COG0531	amino acid
ITG13_17065	COG0583	DNA-binding transcription factor activity
ITG13_17075	COG1609	Transcriptional regulator
ITG13_17080	COG4948	Mandelate Racemase Muconate Lactonizing
ITG13_17100	COG0698	ribose 5-phosphate isomerase
ITG13_17110	COG4166	transmembrane transport
ITG13_17120	COG0583	DNA-binding transcription factor activity
ITG13_17145	COG0546	phosphoglycolate phosphatase activity
ITG13_17150	COG3842	ATPase activity
ITG13_17155	COG0765	amino acid transport
ITG13_17165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_17180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_17180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_17180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_17185	COG2207	Transcriptional regulator
ITG13_17190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG13_17200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_17205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_17220	COG0840	transmembrane signaling receptor activity
ITG13_17225	COG0814	amino acid
ITG13_17230	COG2814	Major facilitator Superfamily
ITG13_17245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG13_17260	COG0840	transmembrane signaling receptor activity
ITG13_17270	COG0583	DNA-binding transcription factor activity
ITG13_17295	COG0583	DNA-binding transcription factor activity
ITG13_17305	COG4948	Mandelate Racemase Muconate Lactonizing
ITG13_17330	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG13_17335	COG3639	organic phosphonate transmembrane transporter activity
ITG13_17340	COG3639	organic phosphonate transmembrane transporter activity
ITG13_17385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG13_17390	COG3047	cAMP biosynthetic process
ITG13_17400	COG4221	oxidoreductase activity
ITG13_17405	COG0583	DNA-binding transcription factor activity
ITG13_17410	COG1733	regulation of RNA biosynthetic process
ITG13_17415	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_17430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG13_17460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG13_17465	COG1595	DNA-templated transcription, initiation
ITG13_17480	COG1901	pseudouridine methyltransferase
ITG13_17535	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG13_17550	COG2964	Protein conserved in bacteria
ITG13_17565	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ITG13_17570	COG3639	organic phosphonate transmembrane transporter activity
ITG13_17575	COG2188	Transcriptional regulator
ITG13_17580	COG3624	Phosphonate C-P lyase system protein PhnG
ITG13_17585	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ITG13_17590	COG3626	phosphonate metabolism
ITG13_17595	COG3627	carbon phosphorus lyase activity
ITG13_17600	COG4107	phosphonate C-P lyase system protein PhnK
ITG13_17605	COG4778	phosphonate C-P lyase system protein PhnL
ITG13_17610	COG3454	Phosphonate metabolism
ITG13_17620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ITG13_17625	COG0110	maltose O-acetyltransferase activity
ITG13_17630	COG0534	Mate efflux family protein
ITG13_17655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ITG13_17660	COG2999	glutathione oxidoreductase activity
ITG13_17670	COG0673	inositol 2-dehydrogenase activity
ITG13_17690	COG0584	glycerophosphoryl diester phosphodiesterase
ITG13_17695	COG3842	ATPase activity
ITG13_17700	COG0395	ABC-type sugar transport system, permease component
ITG13_17705	COG1175	transmembrane transport
ITG13_17725	COG4067	protein conserved in archaea
ITG13_17725	COG0189	ligase activity
ITG13_17730	COG0189	ligase activity
ITG13_17770	COG4977	sequence-specific DNA binding
ITG13_17780	COG2814	Major facilitator Superfamily
ITG13_17790	COG0564	pseudouridine synthase activity
ITG13_17800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG13_17800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG13_17820	COG1131	(ABC) transporter
ITG13_17825	COG2186	Transcriptional regulator
ITG13_17830	COG5001	Diguanylate cyclase
ITG13_17840	COG5001	Diguanylate cyclase
ITG13_17850	COG0745	RESPONSE REGULATOR receiver
ITG13_17855	COG2205	protein histidine kinase activity
ITG13_17860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG13_17865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG13_17870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_17875	COG3037	sugar-specific permease SgaT UlaA
ITG13_17890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG13_17915	COG0745	RESPONSE REGULATOR receiver
ITG13_17920	COG2205	protein histidine kinase activity
ITG13_17945	COG0513	Belongs to the DEAD box helicase family
ITG13_17960	COG3706	GGDEF domain
ITG13_17965	COG1278	Cold shock
ITG13_17970	COG0402	S-adenosylhomocysteine deaminase activity
ITG13_17975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITG13_17995	COG4413	Urea transporter
ITG13_18010	COG0531	amino acid
ITG13_18025	COG1280	lysine exporter protein (LysE YggA)
ITG13_18040	COG1151	hydroxylamine reductase activity
ITG13_18045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG13_18070	COG2926	Belongs to the UPF0265 family
ITG13_18080	COG3132	Protein of unknown function, DUF480
ITG13_18085	COG2827	Endonuclease containing a URI domain
ITG13_18115	COG0443	Heat shock 70 kDa protein
ITG13_18125	COG0179	Fumarylacetoacetate (FAA) hydrolase
ITG13_18130	COG1280	lysine exporter protein (LysE YggA)
ITG13_18135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG13_18145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG13_18155	COG1845	cytochrome c oxidase, subunit III
ITG13_18175	COG1612	heme a metabolic process
ITG13_18180	COG0109	protoheme IX farnesyltransferase activity
ITG13_18200	COG3530	Putative quorum-sensing-regulated virulence factor
ITG13_18205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG13_18210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG13_18215	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ITG13_18215	COG0662	Cupin 2, conserved barrel domain protein
ITG13_18220	COG0668	transmembrane transport
ITG13_18225	COG0569	domain protein
ITG13_18230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG13_18235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG13_18235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG13_18240	COG1765	OsmC-like protein
ITG13_18245	COG2885	chlorophyll binding
ITG13_18255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG13_18265	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG13_18270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG13_18275	COG3842	ATPase activity
ITG13_18295	COG2375	cellular response to nickel ion
ITG13_18300	COG3104	oligopeptide transport
ITG13_18305	COG1760	l-serine dehydratase
ITG13_18325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG13_18330	COG1132	(ABC) transporter
ITG13_18335	COG1132	(ABC) transporter
ITG13_18360	COG0739	heme binding
ITG13_18365	COG0393	Putative heavy-metal-binding
ITG13_18380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG13_18385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITG13_18405	COG0346	lactoylglutathione lyase activity
ITG13_18420	COG2200	EAL domain
ITG13_18425	COG0156	8-amino-7-oxononanoate synthase activity
ITG13_18430	COG1063	alcohol dehydrogenase
ITG13_18480	COG1454	alcohol dehydrogenase
ITG13_18490	COG1011	Hydrolase
ITG13_18520	COG1328	CTP reductase activity
ITG13_18525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG13_18530	COG0583	DNA-binding transcription factor activity
ITG13_18550	COG1289	transmembrane transporter activity
ITG13_18555	COG0210	DNA helicase
ITG13_18565	COG1803	Methylglyoxal synthase
ITG13_18570	COG1879	ABC-type sugar transport system periplasmic component
ITG13_18575	COG0784	Response regulator, receiver
ITG13_18575	COG5002	protein histidine kinase activity
ITG13_18575	COG2198	Histidine kinase
ITG13_18610	COG2223	nitrite transmembrane transporter activity
ITG13_18625	COG0625	glutathione transferase activity
ITG13_18630	COG3064	Membrane
ITG13_18640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_18640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_18640	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ITG13_18645	COG1105	Belongs to the carbohydrate kinase PfkB family
ITG13_18650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_18650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_18655	COG1609	Transcriptional regulator
ITG13_18660	COG0515	serine threonine protein kinase
ITG13_18660	COG2815	serine threonine protein kinase
ITG13_18665	COG2223	nitrite transmembrane transporter activity
ITG13_18675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG13_18680	COG0243	molybdopterin cofactor binding
ITG13_18740	COG1609	Transcriptional regulator
ITG13_18745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG13_18750	COG1879	ABC-type sugar transport system periplasmic component
ITG13_18755	COG1172	Belongs to the binding-protein-dependent transport system permease family
ITG13_18760	COG1129	ABC transporter
ITG13_18765	COG1869	D-ribose catabolic process
ITG13_18785	COG4166	transmembrane transport
ITG13_18790	COG4174	ABC transporter (Permease)
ITG13_18795	COG4239	(ABC) transporter, permease
ITG13_18800	COG4172	Belongs to the ABC transporter superfamily
ITG13_18820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG13_18830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG13_18840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG13_18855	COG0356	it plays a direct role in the translocation of protons across the membrane
ITG13_18865	COG0583	DNA-binding transcription factor activity
ITG13_18875	COG1012	belongs to the aldehyde dehydrogenase family
ITG13_18885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG13_18925	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG13_18945	COG3300	MHYT domain
ITG13_18945	COG5001	Diguanylate cyclase
ITG13_18955	COG0384	phenazine biosynthesis protein PhzF
ITG13_18985	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ITG13_19000	COG2197	response regulator
ITG13_19005	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG13_19020	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG13_19040	COG3119	arylsulfatase activity
ITG13_19045	COG3119	arylsulfatase activity
ITG13_19055	COG0714	Associated with various cellular activities
ITG13_19085	COG0583	DNA-binding transcription factor activity
ITG13_19090	COG1597	lipid kinase activity
ITG13_19095	COG3300	MHYT domain
ITG13_19095	COG5001	Diguanylate cyclase
ITG13_19120	COG0641	radical SAM
ITG13_19130	COG0405	Gamma-glutamyltransferase
ITG13_19145	COG5002	protein histidine kinase activity
ITG13_19145	COG0784	Response regulator, receiver
ITG13_19145	COG2205	protein histidine kinase activity
ITG13_19160	COG1132	(ABC) transporter
ITG13_19165	COG1538	Outer membrane efflux protein
ITG13_19170	COG0784	Response regulator, receiver
ITG13_19170	COG2205	protein histidine kinase activity
ITG13_19175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_19210	COG0840	transmembrane signaling receptor activity
ITG13_19235	COG0583	DNA-binding transcription factor activity
ITG13_19245	COG1881	PFAM PEBP family protein
ITG13_19255	COG2807	transmembrane transport
ITG13_19290	COG1280	lysine exporter protein (LysE YggA)
ITG13_19310	COG0534	Mate efflux family protein
ITG13_19325	COG3385	transposase activity
ITG13_19335	COG0509	glycine decarboxylation via glycine cleavage system
ITG13_19375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG13_19380	COG3706	GGDEF domain
ITG13_19385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ITG13_19390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG13_19405	COG3437	response regulator, receiver
ITG13_19405	COG0784	Response regulator, receiver
ITG13_19410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG13_19420	COG0814	amino acid
ITG13_19425	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ITG13_19430	COG0513	Belongs to the DEAD box helicase family
ITG13_19455	COG2200	EAL domain
ITG13_19470	COG3038	cytochrome b561
ITG13_19475	COG2353	YceI-like domain
ITG13_19480	COG2116	formate transmembrane transporter activity
ITG13_19485	COG0583	DNA-binding transcription factor activity
ITG13_19495	COG3593	DNA synthesis involved in DNA repair
ITG13_19500	COG0737	Belongs to the 5'-nucleotidase family
ITG13_19505	COG0861	Integral membrane protein TerC family
ITG13_19520	COG0513	Belongs to the DEAD box helicase family
ITG13_19535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG13_19540	COG2272	Belongs to the type-B carboxylesterase lipase family
ITG13_19555	COG1566	PFAM secretion protein HlyD family protein
ITG13_19565	COG2985	domain, Protein
ITG13_19575	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ITG13_19590	COG0583	DNA-binding transcription factor activity
ITG13_19605	COG2267	carboxylic ester hydrolase activity
ITG13_19610	COG2067	long-chain fatty acid transport protein
ITG13_19620	COG0501	Belongs to the peptidase M48B family
ITG13_19625	COG2050	protein possibly involved in aromatic compounds catabolism
ITG13_19635	COG4533	DNA binding
ITG13_19665	COG0768	penicillin binding
ITG13_19675	COG1716	ATPase activity
ITG13_19675	COG5001	Diguanylate cyclase
ITG13_19680	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG13_19690	COG4181	ATPase activity
ITG13_19695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ITG13_19705	COG1984	allophanate hydrolase subunit 2
ITG13_19730	COG5001	Diguanylate cyclase
ITG13_19730	COG3300	MHYT domain
ITG13_19740	COG4771	TonB-dependent receptor
ITG13_19740	COG1629	transport
ITG13_19745	COG0583	DNA-binding transcription factor activity
ITG13_19750	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG13_19750	COG1042	CoA-binding domain protein
ITG13_19750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG13_19755	COG3266	domain, Protein
ITG13_19760	COG1181	Belongs to the D-alanine--D-alanine ligase family
ITG13_19775	COG0023	Translation Initiation Factor
ITG13_19795	COG3706	GGDEF domain
ITG13_19800	COG3140	Belongs to the UPF0181 family
ITG13_19825	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ITG13_19830	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ITG13_19845	COG3706	GGDEF domain
ITG13_19855	COG5001	Diguanylate cyclase
ITG13_19855	COG4251	negative regulation of phosphorylation
ITG13_19855	COG2203	Gaf domain
ITG13_19855	COG3706	GGDEF domain
ITG13_19865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ITG13_19870	COG4149	molybdate abc transporter
ITG13_19875	COG0725	ABC transporter, periplasmic molybdate-binding protein
ITG13_19895	COG0488	(ABC) transporter
ITG13_19900	COG4067	protein conserved in archaea
ITG13_19900	COG0189	ligase activity
ITG13_19910	COG0602	queuosine metabolic process
ITG13_19915	COG1328	CTP reductase activity
ITG13_19925	COG2391	methyltransferase activity
ITG13_19945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG13_19975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG13_20030	COG5642	Protein of unknown function (DUF2384)
ITG13_20055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ITG13_20085	COG0318	PFAM AMP-dependent synthetase and ligase
ITG13_20115	COG0534	Mate efflux family protein
ITG13_20140	COG1321	iron dependent repressor
ITG13_20140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG13_20145	COG1121	(ABC) transporter
ITG13_20150	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITG13_20195	COG0848	biopolymer transport protein
ITG13_20200	COG0811	peptide transport
ITG13_20205	COG0811	peptide transport
ITG13_20215	COG4774	siderophore transport
ITG13_20220	COG1301	dicarboxylic acid transport
ITG13_20225	COG2205	protein histidine kinase activity
ITG13_20230	COG0745	RESPONSE REGULATOR receiver
ITG13_20245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITG13_20245	COG1648	precorrin-2 dehydrogenase activity
ITG13_20250	COG2116	formate transmembrane transporter activity
ITG13_20260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG13_20315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ITG13_20325	COG0494	nUDIX hydrolase
ITG13_20330	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ITG13_20380	COG3706	GGDEF domain
ITG13_20410	COG1929	Belongs to the glycerate kinase type-1 family
ITG13_20415	COG0383	alpha-mannosidase activity
ITG13_20420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG13_20420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_20420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG13_20425	COG2188	Transcriptional regulator
ITG13_20450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG13_20455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_20460	COG2067	long-chain fatty acid transport protein
ITG13_20465	COG2267	carboxylic ester hydrolase activity
ITG13_20480	COG3069	C4-dicarboxylate transmembrane transporter activity
ITG13_20485	COG2197	response regulator
ITG13_20490	COG3850	Histidine kinase
ITG13_20505	COG0243	molybdopterin cofactor binding
ITG13_20510	COG3043	anaerobic respiration
ITG13_20525	COG3243	poly(R)-hydroxyalkanoic acid synthase
ITG13_20535	COG0183	Belongs to the thiolase family
ITG13_20580	COG0745	RESPONSE REGULATOR receiver
ITG13_20615	COG0513	Belongs to the DEAD box helicase family
ITG13_20620	COG0523	cobalamin synthesis protein
ITG13_20625	COG0038	chloride channel
ITG13_20635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ITG13_20645	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ITG13_20650	COG1175	transmembrane transport
ITG13_20660	COG1609	Transcriptional regulator
ITG13_20665	COG1017	nitric oxide dioxygenase activity
ITG13_20665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG13_20670	COG3604	Transcriptional regulator
ITG13_20690	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG13_20695	COG1309	transcriptional regulator
ITG13_20700	COG2130	NADP-dependent
ITG13_20710	COG0564	pseudouridine synthase activity
ITG13_20720	COG1686	Belongs to the peptidase S11 family
ITG13_20735	COG3706	GGDEF domain
ITG13_20745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG13_20755	COG3059	membrane
ITG13_20780	COG0251	oxidation-reduction process
ITG13_20795	COG2207	Transcriptional regulator
ITG13_20800	COG1979	alcohol dehydrogenase
ITG13_20805	COG1126	abc transporter atp-binding protein
ITG13_20810	COG0765	amino acid transport
ITG13_20820	COG0765	amino acid transport
ITG13_20835	COG3708	Transcriptional regulator
ITG13_20835	COG2207	Transcriptional regulator
ITG13_20845	COG1280	lysine exporter protein (LysE YggA)
ITG13_20875	COG2824	Alkylphosphonate utilization operon protein PhnA
ITG13_20895	COG2273	Hydrolase Family 16
ITG13_20895	COG5297	Belongs to the glycosyl hydrolase family 6
ITG13_20915	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG13_20945	COG1132	(ABC) transporter
ITG13_20960	COG1902	pentaerythritol trinitrate reductase activity
ITG13_20960	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG13_20970	COG3710	Transcriptional regulator
ITG13_20985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG13_20990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_21000	COG2985	domain, Protein
ITG13_21020	COG1024	Enoyl-CoA hydratase
ITG13_21050	COG1120	ATPase activity
ITG13_21060	COG2133	pyrroloquinoline quinone binding
ITG13_21065	COG1278	Cold shock
ITG13_21070	COG4681	YaeQ
ITG13_21080	COG0302	gtp cyclohydrolase
ITG13_21110	COG2897	thiosulfate sulfurtransferase activity
ITG13_21115	COG3706	GGDEF domain
ITG13_21115	COG2203	Gaf domain
ITG13_21115	COG5001	Diguanylate cyclase
ITG13_21115	COG4251	negative regulation of phosphorylation
ITG13_21150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG13_21160	COG0840	transmembrane signaling receptor activity
ITG13_21165	COG1522	sequence-specific DNA binding
ITG13_21185	COG2814	Major facilitator Superfamily
ITG13_21190	COG0583	DNA-binding transcription factor activity
ITG13_21195	COG2205	protein histidine kinase activity
ITG13_21195	COG2198	Histidine kinase
ITG13_21195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG13_21195	COG0784	Response regulator, receiver
ITG13_21200	COG3437	response regulator, receiver
ITG13_21205	COG4604	ABC transporter, ATP-binding protein
ITG13_21210	COG4605	iron ion homeostasis
ITG13_21215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG13_21220	COG4607	ABC-type enterochelin transport system periplasmic component
ITG13_21250	COG0628	permease
ITG13_21260	COG1566	PFAM secretion protein HlyD family protein
ITG13_21270	COG3706	GGDEF domain
ITG13_21295	COG0402	S-adenosylhomocysteine deaminase activity
ITG13_21310	COG0583	DNA-binding transcription factor activity
ITG13_21330	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ITG13_21335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ITG13_21340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG13_21345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG13_21350	COG1116	anion transmembrane transporter activity
ITG13_21355	COG0351	phosphomethylpyrimidine kinase
ITG13_21360	COG0697	spore germination
ITG13_21405	COG2205	protein histidine kinase activity
ITG13_21430	COG0628	permease
ITG13_21455	COG1785	Belongs to the alkaline phosphatase family
ITG13_21605	COG4695	Portal protein
ITG13_21670	COG1403	HNH endonuclease
ITG13_21695	COG0582	viral genome integration into host DNA
ITG13_21700	COG0516	GMP reductase activity
ITG13_21725	COG0534	Mate efflux family protein
ITG13_21730	COG0583	DNA-binding transcription factor activity
ITG13_21735	COG0366	Alpha amylase catalytic
ITG13_21750	COG0697	spore germination
ITG13_21770	COG0604	alcohol dehydrogenase
ITG13_21815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG13_21820	COG0513	Belongs to the DEAD box helicase family
ITG13_21825	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ITG13_21840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITG13_21875	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG13_21885	COG0667	Aldo Keto reductase
ITG13_21890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG13_21895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ITG13_21900	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ITG13_21905	COG0513	Belongs to the DEAD box helicase family
ITG13_21915	COG2176	DNA-directed DNA polymerase activity
ITG13_21930	COG0513	Belongs to the DEAD box helicase family
ITG13_21935	COG4989	oxidoreductase activity
ITG13_21955	COG1538	Outer membrane efflux protein
ITG13_21960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG13_22005	COG0668	transmembrane transport
ITG13_22015	COG4232	protein-disulfide reductase activity
ITG13_22020	COG3118	belongs to the thioredoxin family
ITG13_22035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG13_22040	COG0697	spore germination
ITG13_22055	COG2814	Major facilitator Superfamily
ITG13_22060	COG0583	DNA-binding transcription factor activity
ITG13_22065	COG5001	Diguanylate cyclase
ITG13_22070	COG0739	heme binding
ITG13_22095	COG3314	Sporulation integral membrane protein YlbJ
ITG13_22105	COG0366	Alpha amylase catalytic
ITG13_22110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG13_22115	COG0784	Response regulator, receiver
ITG13_22115	COG0835	chemotaxis
ITG13_22120	COG2096	Adenosyltransferase
ITG13_22125	COG0748	coenzyme F420 binding
ITG13_22130	COG3721	Heme iron utilization protein
ITG13_22140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ITG13_22145	COG0811	peptide transport
ITG13_22150	COG0848	biopolymer transport protein
ITG13_22160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG13_22165	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG13_22210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ITG13_22215	COG0633	Ferredoxin
ITG13_22215	COG3217	Mosc domain protein beta barrel domain protein
ITG13_22225	COG0418	dihydroorotase activity
ITG13_22230	COG2354	Protein conserved in bacteria
ITG13_22240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG13_22255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG13_22255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG13_22260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG13_22265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG13_22270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG13_22300	COG0730	response to heat
ITG13_22305	COG0280	phosphate acetyltransferase
ITG13_22310	COG1414	Transcriptional regulator
ITG13_22315	COG1012	belongs to the aldehyde dehydrogenase family
ITG13_22360	COG0583	DNA-binding transcription factor activity
ITG13_22385	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_22400	COG3706	GGDEF domain
ITG13_22420	COG0583	DNA-binding transcription factor activity
ITG13_22440	COG1136	(ABC) transporter
ITG13_22445	COG0577	efflux transmembrane transporter activity
ITG13_22465	COG3119	arylsulfatase activity
ITG13_22475	COG0641	radical SAM
ITG13_22485	COG0583	DNA-binding transcription factor activity
ITG13_22495	COG0387	Pfam Sodium calcium exchanger
ITG13_22505	COG2239	Acts as a magnesium transporter
ITG13_22525	COG0668	transmembrane transport
ITG13_22535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG13_22540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG13_22580	COG3833	ABC-type maltose transport systems, permease component
ITG13_22585	COG1175	transmembrane transport
ITG13_22595	COG3842	ATPase activity
ITG13_22605	COG0840	transmembrane signaling receptor activity
ITG13_22610	COG0714	Associated with various cellular activities
ITG13_22625	COG2304	oxidoreductase activity
ITG13_22630	COG2304	oxidoreductase activity
ITG13_22645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG13_22650	COG0581	inorganic phosphate transmembrane transporter activity
ITG13_22655	COG0573	inorganic phosphate transmembrane transporter activity
ITG13_22665	COG0840	transmembrane signaling receptor activity
ITG13_22675	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITG13_22680	COG3240	lipase activity
ITG13_22685	COG0513	Belongs to the DEAD box helicase family
ITG13_22695	COG1388	LysM domain
ITG13_22695	COG1376	ErfK ybiS ycfS ynhG family protein
ITG13_22700	COG0813	purine-nucleoside phosphorylase activity
ITG13_22730	COG1566	PFAM secretion protein HlyD family protein
ITG13_22735	COG4720	Psort location CytoplasmicMembrane, score
ITG13_22740	COG1122	ATPase activity
ITG13_22755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ITG13_22760	COG1640	4-alpha-glucanotransferase
ITG13_22765	COG0058	SHG alpha-glucan phosphorylase activity
ITG13_22770	COG2909	trisaccharide binding
ITG13_22785	COG1999	signal sequence binding
ITG13_22795	COG1162	GTPase activity
ITG13_22800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ITG13_22835	COG0583	DNA-binding transcription factor activity
ITG13_22870	COG4580	involved in the transport of maltose and maltodextrins
ITG13_22890	COG0204	Acyl-transferase
ITG13_22895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG13_22900	COG3615	Tellurite resistance protein tehB
ITG13_22905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG13_22910	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG13_22915	COG0753	catalase activity
ITG13_22920	COG1929	Belongs to the glycerate kinase type-1 family
ITG13_22930	COG3623	hexulose-6-phosphate isomerase
ITG13_22935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITG13_22940	COG0561	phosphatase activity
ITG13_23005	COG0583	DNA-binding transcription factor activity
ITG13_23010	COG3214	Protein conserved in bacteria
ITG13_23020	COG0561	phosphatase activity
ITG13_23045	COG0798	PFAM Bile acid sodium symporter
ITG13_23050	COG0583	DNA-binding transcription factor activity
ITG13_23060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG13_23065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ITG13_23070	COG1349	DNA-binding transcription factor activity
ITG13_23075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ITG13_23080	COG1028	Short-chain dehydrogenase reductase Sdr
ITG13_23085	COG0583	DNA-binding transcription factor activity
ITG13_23095	COG1794	racemase activity, acting on amino acids and derivatives
ITG13_23115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG13_23125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITG13_23145	COG3119	arylsulfatase activity
ITG13_23150	COG0641	radical SAM
ITG13_23155	COG0583	DNA-binding transcription factor activity
ITG13_23160	COG2814	Major facilitator Superfamily
ITG13_23200	COG0110	maltose O-acetyltransferase activity
ITG13_23205	COG1609	Transcriptional regulator
ITG13_23210	COG2723	6-phospho-beta-galactosidase activity
ITG13_23225	COG0346	lactoylglutathione lyase activity
ITG13_23240	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG13_23245	COG0583	DNA-binding transcription factor activity
ITG13_23250	COG0534	Mate efflux family protein
ITG13_23255	COG1024	Enoyl-CoA hydratase
ITG13_23260	COG0300	oxidoreductase activity
ITG13_23270	COG2723	6-phospho-beta-galactosidase activity
ITG13_23275	COG1263	PTS System
ITG13_23275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG13_23280	COG3265	gluconokinase activity
ITG13_23285	COG0129	dihydroxy-acid dehydratase activity
ITG13_23290	COG1609	Transcriptional regulator