locus-tag	class	description
ITG08_00025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG08_00030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITG08_00030	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG08_00040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG08_00065	COG0786	glutamate:sodium symporter activity
ITG08_00080	COG0784	Response regulator, receiver
ITG08_00080	COG5002	protein histidine kinase activity
ITG08_00095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ITG08_00100	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ITG08_00105	COG2885	chlorophyll binding
ITG08_00110	COG0823	Involved in the tonB-independent uptake of proteins
ITG08_00125	COG0811	peptide transport
ITG08_00130	COG0824	Thioesterase
ITG08_00140	COG4890	Cyd operon protein YbgT
ITG08_00145	COG1294	oxidase, subunit
ITG08_00150	COG1271	oxidase subunit
ITG08_00155	COG2255	four-way junction helicase activity
ITG08_00160	COG0632	four-way junction helicase activity
ITG08_00165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ITG08_00170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ITG08_00175	COG1801	Protein of unknown function DUF72
ITG08_00180	COG4106	trans-aconitate 2-methyltransferase activity
ITG08_00185	COG0500	methyltransferase
ITG08_00190	COG0189	ligase activity
ITG08_00190	COG4067	protein conserved in archaea
ITG08_00205	COG3383	formate dehydrogenase (NAD+) activity
ITG08_00210	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ITG08_00215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ITG08_00220	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ITG08_00225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG08_00230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ITG08_00235	COG0745	RESPONSE REGULATOR receiver
ITG08_00240	COG3381	protein complex oligomerization
ITG08_00245	COG1609	Transcriptional regulator
ITG08_00250	COG3070	regulator of competence-specific genes
ITG08_00270	COG0297	glycogen (starch) synthase activity
ITG08_00275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG08_00280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG08_00290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ITG08_00300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ITG08_00305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ITG08_00310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ITG08_00315	COG0542	response to heat
ITG08_00320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ITG08_00325	COG1278	Cold shock
ITG08_00335	COG1187	pseudouridine synthase activity
ITG08_00345	COG1199	ATP-dependent helicase activity
ITG08_00365	COG2850	peptidyl-arginine hydroxylation
ITG08_00375	COG2814	Major facilitator Superfamily
ITG08_00380	COG1770	oligopeptidase
ITG08_00385	COG0708	Exodeoxyribonuclease III
ITG08_00390	COG4160	amino acid transport
ITG08_00415	COG1882	Formate acetyltransferase
ITG08_00425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG08_00430	COG3013	Belongs to the UPF0304 family
ITG08_00440	COG2766	serine protein kinase
ITG08_00445	COG2718	Belongs to the UPF0229 family
ITG08_00450	COG2719	SpoVR family
ITG08_00455	COG0616	signal peptide processing
ITG08_00460	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_00465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG08_00480	COG0835	chemotaxis
ITG08_00480	COG0784	Response regulator, receiver
ITG08_00485	COG1940	carbohydrate kinase activity
ITG08_00490	COG0469	pyruvate kinase activity
ITG08_00495	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG08_00520	COG0084	hydrolase, TatD family'
ITG08_00535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITG08_00540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG08_00565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG08_00570	COG0416	fatty acid biosynthetic process
ITG08_00575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ITG08_00580	COG1399	metal-binding, possibly nucleic acid-binding protein
ITG08_00590	COG0564	pseudouridine synthase activity
ITG08_00595	COG1530	ribonuclease E activity
ITG08_00600	COG0659	secondary active sulfate transmembrane transporter activity
ITG08_00605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITG08_00610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ITG08_00615	COG2982	Protein involved in outer membrane biogenesis
ITG08_00620	COG0572	uridine kinase
ITG08_00625	COG0489	protein tyrosine kinase activity
ITG08_00630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG08_00630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG08_00640	COG2186	Transcriptional regulator
ITG08_00645	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG08_00655	COG0653	protein targeting
ITG08_00660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG08_00665	COG3706	GGDEF domain
ITG08_00675	COG3092	negative regulation of chromosome organization
ITG08_00680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG08_00685	COG0857	belongs to the CobB CobQ family
ITG08_00685	COG0280	phosphate acetyltransferase
ITG08_00690	COG0435	Glutathione S-transferase
ITG08_00700	COG0444	Belongs to the ABC transporter superfamily
ITG08_00705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG08_00710	COG0601	transmembrane transport
ITG08_00720	COG0314	molybdopterin synthase activity
ITG08_00725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ITG08_00730	COG0315	cyclic pyranopterin monophosphate synthase activity
ITG08_00735	COG0521	Mo-molybdopterin cofactor biosynthetic process
ITG08_00740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ITG08_00745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ITG08_00750	COG2198	Histidine kinase
ITG08_00755	COG2204	response regulator
ITG08_00760	COG0556	nucleotide-excision repair
ITG08_00770	COG2211	Major facilitator Superfamily
ITG08_00780	COG4580	involved in the transport of maltose and maltodextrins
ITG08_00790	COG3250	beta-galactosidase activity
ITG08_00795	COG1609	Transcriptional regulator
ITG08_00800	COG4657	Part of a membrane complex involved in electron transport
ITG08_00805	COG2878	Part of a membrane complex involved in electron transport
ITG08_00810	COG4656	Part of a membrane complex involved in electron transport
ITG08_00815	COG4658	electron transport chain
ITG08_00820	COG4659	FMN binding
ITG08_00825	COG4660	Part of a membrane complex involved in electron transport
ITG08_00830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ITG08_00835	COG0346	lactoylglutathione lyase activity
ITG08_00845	COG2885	chlorophyll binding
ITG08_00855	COG2056	Na+-H+ antiporter family
ITG08_00865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ITG08_00885	COG1454	alcohol dehydrogenase
ITG08_00885	COG1012	belongs to the aldehyde dehydrogenase family
ITG08_00890	COG2095	MarC family integral membrane protein
ITG08_00895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG08_00900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG08_00905	COG1757	Na H antiporter
ITG08_00920	COG3081	Nucleoid-associated protein
ITG08_00925	COG3082	Protein of unknown function (DUF1414)
ITG08_00930	COG3083	sulfuric ester hydrolase activity
ITG08_00955	COG0582	viral genome integration into host DNA
ITG08_00995	COG2801	Transposase and inactivated derivatives
ITG08_01010	COG2205	protein histidine kinase activity
ITG08_01100	COG0840	transmembrane signaling receptor activity
ITG08_01105	COG0123	including yeast histone deacetylase and acetoin utilization protein
ITG08_01120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITG08_01125	COG0778	Nitroreductase
ITG08_01130	COG1902	pentaerythritol trinitrate reductase activity
ITG08_01130	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG08_01135	COG0616	signal peptide processing
ITG08_01140	COG0252	asparaginase activity
ITG08_01145	COG3139	Protein of unknown function (DUF1315)
ITG08_01155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG08_01160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG08_01175	COG2226	methyltransferase
ITG08_01195	COG1785	Belongs to the alkaline phosphatase family
ITG08_01200	COG2983	Belongs to the UPF0260 family
ITG08_01210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG08_01215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ITG08_01220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ITG08_01225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ITG08_01230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ITG08_01235	COG2832	Protein of unknown function (DUF454)
ITG08_01245	COG0745	RESPONSE REGULATOR receiver
ITG08_01250	COG0583	DNA-binding transcription factor activity
ITG08_01255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ITG08_01260	COG1286	toxin biosynthetic process
ITG08_01265	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ITG08_01270	COG0285	dihydrofolate synthase activity
ITG08_01275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ITG08_01280	COG0101	tRNA pseudouridine synthase activity
ITG08_01290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITG08_01295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG08_01300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITG08_01310	COG0431	NADPH-dependent FMN reductase
ITG08_01320	COG3101	peptidyl-lysine hydroxylation
ITG08_01325	COG2860	membrane
ITG08_01330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ITG08_01340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ITG08_01350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG08_01355	COG0583	DNA-binding transcription factor activity
ITG08_01360	COG2951	lytic endotransglycosylase activity
ITG08_01365	COG3100	YcgL domain-containing protein
ITG08_01370	COG0850	regulation of cytokinetic process
ITG08_01375	COG2894	cell division
ITG08_01380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ITG08_01385	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ITG08_01390	COG0318	PFAM AMP-dependent synthetase and ligase
ITG08_01395	COG0596	Alpha beta hydrolase
ITG08_01410	COG1214	PFAM Peptidase M22, glycoprotease
ITG08_01415	COG1199	ATP-dependent helicase activity
ITG08_01425	COG0788	formyltetrahydrofolate deformylase activity
ITG08_01430	COG3102	Protein conserved in bacteria
ITG08_01435	COG0018	arginyl-trna synthetase
ITG08_01455	COG1918	ferrous iron import across plasma membrane
ITG08_01465	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ITG08_01470	COG1121	(ABC) transporter
ITG08_01475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG08_01485	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG08_01490	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG08_01495	COG0567	Dehydrogenase, E1 component
ITG08_01500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG08_01505	COG1053	succinate dehydrogenase
ITG08_01510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ITG08_01525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ITG08_01535	COG0033	Phosphoglucomutase
ITG08_01540	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ITG08_01545	COG0596	Alpha beta hydrolase
ITG08_01570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ITG08_01575	COG2190	(PTS) system
ITG08_01575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG08_01575	COG1263	PTS System
ITG08_01580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITG08_01585	COG1940	carbohydrate kinase activity
ITG08_01585	COG1846	Transcriptional regulator
ITG08_01590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG08_01590	COG4651	solute:proton antiporter activity
ITG08_01595	COG0367	asparagine synthase
ITG08_01605	COG3104	oligopeptide transport
ITG08_01610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ITG08_01615	COG0563	adenylate kinase activity
ITG08_01620	COG0326	Molecular chaperone. Has ATPase activity
ITG08_01625	COG3710	Transcriptional regulator
ITG08_01640	COG0622	Phosphoesterase
ITG08_01665	COG1090	epimerase
ITG08_01670	COG0300	oxidoreductase activity
ITG08_01675	COG3118	belongs to the thioredoxin family
ITG08_01680	COG0330	HflC and HflK could
ITG08_01690	COG0789	Transcriptional regulator
ITG08_01710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ITG08_01715	COG3115	cell septum assembly
ITG08_01720	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ITG08_01730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_01740	COG2190	(PTS) system
ITG08_01745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG08_01750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG08_01755	COG2837	iron assimilation
ITG08_01780	COG1393	Belongs to the ArsC family
ITG08_01785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG08_01800	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ITG08_01805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITG08_01810	COG2716	regulation of RNA biosynthetic process
ITG08_01840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG08_01890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITG08_01930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITG08_01945	COG4783	chaperone-mediated protein folding
ITG08_01950	COG1393	Belongs to the ArsC family
ITG08_01970	COG2233	PERMEase
ITG08_01980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ITG08_01985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ITG08_01990	COG0121	glutamine amidotransferase
ITG08_01995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG08_02000	COG1960	acyl-CoA dehydrogenase activity
ITG08_02010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITG08_02015	COG0328	RNA-DNA hybrid ribonuclease activity
ITG08_02020	COG2226	methyltransferase
ITG08_02025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG08_02030	COG0741	lytic transglycosylase activity
ITG08_02030	COG1388	LysM domain
ITG08_02040	COG3021	interspecies interaction between organisms
ITG08_02045	COG0347	Belongs to the P(II) protein family
ITG08_02055	COG0037	tRNA processing
ITG08_02060	COG0825	malonyl-CoA metabolic process
ITG08_02065	COG0587	DNA-directed DNA polymerase activity
ITG08_02070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ITG08_02080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG08_02085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITG08_02090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG08_02095	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ITG08_02105	COG0750	zinc metalloprotease
ITG08_02115	COG0575	Belongs to the CDS family
ITG08_02120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ITG08_02125	COG0233	cytoplasmic translational termination
ITG08_02130	COG0528	UMP kinase activity
ITG08_02135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ITG08_02140	COG0052	Belongs to the universal ribosomal protein uS2 family
ITG08_02145	COG0024	Methionine aminopeptidase
ITG08_02150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ITG08_02160	COG0564	pseudouridine synthase activity
ITG08_02165	COG3098	single-species biofilm formation
ITG08_02190	COG1671	Belongs to the UPF0178 family
ITG08_02200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG08_02210	COG0254	rRNA binding
ITG08_02215	COG1720	tRNA m6t6A37 methyltransferase activity
ITG08_02220	COG0442	prolyl-tRNA aminoacylation
ITG08_02245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ITG08_02250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG08_02255	COG0366	Alpha amylase catalytic
ITG08_02260	COG1263	PTS System
ITG08_02260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG08_02265	COG1609	Transcriptional regulator
ITG08_02275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG08_02280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ITG08_02285	COG2011	ABC-type metal ion transport system permease component
ITG08_02290	COG1464	Belongs to the NlpA lipoprotein family
ITG08_02295	COG4580	involved in the transport of maltose and maltodextrins
ITG08_02300	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ITG08_02310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG08_02310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITG08_02325	COG1611	Belongs to the LOG family
ITG08_02330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG08_02335	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ITG08_02350	COG0583	DNA-binding transcription factor activity
ITG08_02355	COG0301	tRNA thio-modification
ITG08_02355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG08_02365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITG08_02370	COG1722	exodeoxyribonuclease VII activity
ITG08_02375	COG0142	geranyltranstransferase activity
ITG08_02380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ITG08_02390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITG08_02395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ITG08_02400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG08_02420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG08_02420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG08_02425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ITG08_02430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ITG08_02445	COG1073	alpha beta
ITG08_02450	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ITG08_02455	COG2252	PERMEase
ITG08_02460	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG08_02480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG08_02500	COG1609	Transcriptional regulator
ITG08_02505	COG2017	converts alpha-aldose to the beta-anomer
ITG08_02515	COG1085	galactose-1-phosphate uridylyltransferase
ITG08_02520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITG08_02525	COG1609	Transcriptional regulator
ITG08_02530	COG3250	beta-galactosidase activity
ITG08_02540	COG0395	ABC-type sugar transport system, permease component
ITG08_02545	COG1175	transmembrane transport
ITG08_02555	COG0534	Mate efflux family protein
ITG08_02560	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_02570	COG1609	Transcriptional regulator
ITG08_02575	COG0583	DNA-binding transcription factor activity
ITG08_02580	COG2059	Chromate
ITG08_02585	COG2226	methyltransferase
ITG08_02645	COG4964	Belongs to the GSP D family
ITG08_02675	COG1022	Amp-dependent synthetase and ligase
ITG08_02690	COG0583	DNA-binding transcription factor activity
ITG08_02695	COG4628	conserved protein (DUF2132)
ITG08_02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG08_02730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ITG08_02740	COG0560	Phosphoserine phosphatase
ITG08_02750	COG0813	purine-nucleoside phosphorylase activity
ITG08_02760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ITG08_02765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ITG08_02770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG08_02775	COG0084	hydrolase, TatD family'
ITG08_02780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ITG08_02795	COG3153	acetyltransferase
ITG08_02800	COG3154	lipid carrier protein
ITG08_02810	COG0826	peptidase U32
ITG08_02815	COG0826	peptidase U32
ITG08_02820	COG0534	Mate efflux family protein
ITG08_02835	COG1185	polyribonucleotide nucleotidyltransferase activity
ITG08_02840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ITG08_02845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ITG08_02850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ITG08_02855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ITG08_02860	COG0195	Participates in both transcription termination and antitermination
ITG08_02865	COG0779	Required for maturation of 30S ribosomal subunits
ITG08_02880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG08_02885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG08_02890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ITG08_02895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITG08_02900	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ITG08_02905	COG1534	Rna-binding protein
ITG08_02910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG08_02915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG08_02920	COG2027	D-alanyl-D-alanine carboxypeptidase
ITG08_02925	COG2239	Acts as a magnesium transporter
ITG08_02930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITG08_02935	COG0739	heme binding
ITG08_02950	COG0316	Belongs to the HesB IscA family
ITG08_02955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ITG08_02960	COG0628	permease
ITG08_02965	COG2813	Specifically methylates the guanine in position
ITG08_02970	COG0784	Response regulator, receiver
ITG08_02970	COG2205	protein histidine kinase activity
ITG08_02975	COG0747	negative chemotaxis
ITG08_02985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG08_02990	COG0444	Belongs to the ABC transporter superfamily
ITG08_02995	COG4608	Belongs to the ABC transporter superfamily
ITG08_03005	COG2971	BadF BadG BcrA BcrD
ITG08_03020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG08_03025	COG3842	ATPase activity
ITG08_03035	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG08_03040	COG0004	ammonium transporteR
ITG08_03055	COG1049	propionate catabolic process, 2-methylcitrate cycle
ITG08_03060	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITG08_03065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITG08_03070	COG1643	Atp-dependent helicase
ITG08_03075	COG1489	DNA binding
ITG08_03095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG08_03100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ITG08_03105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ITG08_03110	COG0842	Transport permease protein
ITG08_03115	COG1131	(ABC) transporter
ITG08_03120	COG0659	secondary active sulfate transmembrane transporter activity
ITG08_03125	COG0288	reversible hydration of carbon dioxide
ITG08_03140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG08_03145	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITG08_03150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ITG08_03155	COG2186	Transcriptional regulator
ITG08_03165	COG0157	Belongs to the NadC ModD family
ITG08_03175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG08_03180	COG1459	type II secretion system
ITG08_03190	COG0237	dephospho-CoA kinase activity
ITG08_03195	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ITG08_03205	COG0335	large ribosomal subunit rRNA binding
ITG08_03210	COG0336	Belongs to the RNA methyltransferase TrmD family
ITG08_03215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ITG08_03225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ITG08_03230	COG4137	Cytochrome C assembly protein
ITG08_03235	COG4536	flavin adenine dinucleotide binding
ITG08_03240	COG1854	S-ribosylhomocysteine lyase activity
ITG08_03255	COG0612	Peptidase, M16
ITG08_03260	COG1238	metal cluster binding
ITG08_03270	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ITG08_03275	COG0511	ligase activity, forming carbon-carbon bonds
ITG08_03275	COG5016	pyruvate
ITG08_03280	COG3630	sodium ion export across plasma membrane
ITG08_03335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ITG08_03340	COG0527	aspartate kinase activity
ITG08_03350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITG08_03355	COG1546	Belongs to the CinA family
ITG08_03360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ITG08_03365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ITG08_03375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ITG08_03380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ITG08_03385	COG0585	pseudouridine synthase activity
ITG08_03395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ITG08_03400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ITG08_03405	COG0148	phosphopyruvate hydratase activity
ITG08_03410	COG0504	CTP synthase activity
ITG08_03415	COG3956	TIGRFAM MazG family protein
ITG08_03420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG08_03425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG08_03430	COG3437	response regulator, receiver
ITG08_03430	COG3850	Histidine kinase
ITG08_03430	COG4999	Histidine kinase
ITG08_03430	COG2205	protein histidine kinase activity
ITG08_03435	COG0736	holo-[acyl-carrier-protein] synthase activity
ITG08_03440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ITG08_03445	COG1381	Involved in DNA repair and RecF pathway recombination
ITG08_03450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ITG08_03455	COG0571	ribonuclease III activity
ITG08_03465	COG0481	GTPase activity
ITG08_03485	COG1595	DNA-templated transcription, initiation
ITG08_03490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ITG08_03495	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ITG08_03500	COG0354	folic acid binding
ITG08_03515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG08_03520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG08_03525	COG3079	Belongs to the UPF0149 family
ITG08_03530	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ITG08_03540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ITG08_03545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ITG08_03550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITG08_03570	COG0668	transmembrane transport
ITG08_03575	COG0191	fructose-bisphosphate aldolase activity
ITG08_03590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG08_03595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ITG08_03605	COG3091	SprT-like family
ITG08_03610	COG2356	endonuclease I
ITG08_03615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ITG08_03620	COG0189	ligase activity
ITG08_03625	COG1678	Uncharacterized ACR, COG1678
ITG08_03630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ITG08_03650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ITG08_03655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITG08_03660	COG0762	integral membrane protein
ITG08_03675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ITG08_03680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITG08_03685	COG2066	Belongs to the glutaminase family
ITG08_03700	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ITG08_03705	COG0741	lytic transglycosylase activity
ITG08_03745	COG0840	transmembrane signaling receptor activity
ITG08_03860	COG0795	lipopolysaccharide-transporting ATPase activity
ITG08_03865	COG0795	lipopolysaccharide-transporting ATPase activity
ITG08_03870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG08_03875	COG2927	DNA polymerase III (CHI subunit)
ITG08_03880	COG0525	valine-tRNA ligase activity
ITG08_03890	COG0456	acetyltransferase
ITG08_03920	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG08_03925	COG0251	oxidation-reduction process
ITG08_03930	COG0204	Acyl-transferase
ITG08_03935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ITG08_03940	COG5007	Belongs to the BolA IbaG family
ITG08_03950	COG2854	intermembrane phospholipid transfer
ITG08_03955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ITG08_03960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ITG08_03965	COG1127	ABC transporter
ITG08_03975	COG0517	IMP dehydrogenase activity
ITG08_03975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ITG08_03980	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ITG08_03990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ITG08_03995	COG1137	ATPase activity
ITG08_04005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG08_04010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_04015	COG1660	Displays ATPase and GTPase activities
ITG08_04020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_04025	COG2239	Acts as a magnesium transporter
ITG08_04030	COG0312	modulator of DNA gyrase
ITG08_04035	COG3028	Belongs to the UPF0307 family
ITG08_04040	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ITG08_04045	COG1178	ABC-type Fe3 transport system permease component
ITG08_04050	COG4143	(ABC) transporter
ITG08_04055	COG0163	prenyltransferase activity
ITG08_04060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG08_04065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ITG08_04075	COG2105	PFAM AIG2 family protein
ITG08_04080	COG2911	Protein conserved in bacteria
ITG08_04085	COG0729	surface antigen
ITG08_04090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG08_04100	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ITG08_04135	COG0529	Catalyzes the synthesis of activated sulfate
ITG08_04140	COG0471	metal ion transport
ITG08_04140	COG3273	potassium ion transport
ITG08_04145	COG2895	sulfate adenylyltransferase (ATP) activity
ITG08_04150	COG0175	sulfate reduction
ITG08_04155	COG0737	Belongs to the 5'-nucleotidase family
ITG08_04200	COG2153	protein acetylation
ITG08_04210	COG3266	domain, Protein
ITG08_04210	COG3061	Opacity-associated protein A
ITG08_04215	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG08_04225	COG0203	ribosomal protein L17
ITG08_04230	COG0202	RNA polymerase activity
ITG08_04235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ITG08_04240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ITG08_04245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ITG08_04250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ITG08_04255	COG0201	protein transport
ITG08_04260	COG0200	Binds to the 23S rRNA
ITG08_04265	COG1841	ribosomal large subunit assembly
ITG08_04270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ITG08_04275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ITG08_04280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ITG08_04285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ITG08_04290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ITG08_04295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ITG08_04300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ITG08_04305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ITG08_04310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ITG08_04320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ITG08_04325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ITG08_04335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ITG08_04340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ITG08_04345	COG0089	rRNA binding
ITG08_04350	COG0088	Forms part of the polypeptide exit tunnel
ITG08_04355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ITG08_04365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ITG08_04370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITG08_04390	COG2923	Belongs to the DsrF TusC family
ITG08_04395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ITG08_04400	COG2964	Protein conserved in bacteria
ITG08_04405	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG08_04415	COG2900	Belongs to the SlyX family
ITG08_04420	COG1446	asparaginase
ITG08_04425	COG1047	Peptidyl-prolyl cis-trans
ITG08_04440	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG08_04445	COG0488	(ABC) transporter
ITG08_04455	COG0429	hydrolase of the alpha beta-hydrolase fold
ITG08_04460	COG3089	Belongs to the UPF0270 family
ITG08_04465	COG3954	Phosphoribulokinase
ITG08_04470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG08_04480	COG1012	belongs to the aldehyde dehydrogenase family
ITG08_04490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ITG08_04495	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG08_04505	COG0180	Tryptophanyl-tRNA synthetase
ITG08_04515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITG08_04520	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITG08_04530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ITG08_04565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ITG08_04575	COG0678	peroxiredoxin activity
ITG08_04575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG08_04580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG08_04585	COG0251	oxidation-reduction process
ITG08_04595	COG0165	Argininosuccinate lyase
ITG08_04595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG08_04610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ITG08_04615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG08_04620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ITG08_04630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITG08_04635	COG0460	homoserine dehydrogenase
ITG08_04635	COG0527	aspartate kinase activity
ITG08_04640	COG0626	cystathionine gamma-synthase activity
ITG08_04645	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ITG08_04650	COG0281	malic enzyme
ITG08_04655	COG0254	rRNA binding
ITG08_04660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITG08_04665	COG1609	Transcriptional regulator
ITG08_04675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ITG08_04680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ITG08_04685	COG1575	Belongs to the MenA family. Type 1 subfamily
ITG08_04690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG08_04695	COG3074	FtsZ-dependent cytokinesis
ITG08_04700	COG1494	fructose-1,6-bisphosphatase
ITG08_04715	COG3152	Membrane
ITG08_04725	COG0149	triose-phosphate isomerase activity
ITG08_04735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITG08_04745	COG0745	RESPONSE REGULATOR receiver
ITG08_04750	COG2205	protein histidine kinase activity
ITG08_04760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITG08_04770	COG1027	Aspartate ammonia-lyase
ITG08_04775	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG08_04780	COG1288	antiporter activity
ITG08_04790	COG0549	Belongs to the carbamate kinase family
ITG08_04795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ITG08_04800	COG0540	Belongs to the ATCase OTCase family
ITG08_04805	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ITG08_04810	COG1438	arginine binding
ITG08_04815	COG4232	protein-disulfide reductase activity
ITG08_04825	COG3263	regulation of cellular component size
ITG08_04835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_04850	COG2205	protein histidine kinase activity
ITG08_04850	COG2198	Histidine kinase
ITG08_04850	COG0784	Response regulator, receiver
ITG08_04855	COG2814	Major facilitator Superfamily
ITG08_04870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG08_04875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ITG08_04880	COG0511	ligase activity, forming carbon-carbon bonds
ITG08_04885	COG0439	Biotin carboxylase
ITG08_04890	COG2264	protein methyltransferase activity
ITG08_04895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITG08_04900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ITG08_04905	COG0789	Transcriptional regulator
ITG08_04910	COG0138	bifunctional purine biosynthesis protein purh
ITG08_04915	COG0151	Belongs to the GarS family
ITG08_04930	COG1253	flavin adenine dinucleotide binding
ITG08_04935	COG3068	Protein conserved in bacteria
ITG08_04945	COG1573	uracil-dna glycosylase
ITG08_04955	COG2816	NAD+ diphosphatase activity
ITG08_04960	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ITG08_04975	COG0222	ribosome binding
ITG08_04980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ITG08_04985	COG0081	regulation of translation
ITG08_04995	COG0250	Participates in transcription elongation, termination and antitermination
ITG08_05000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITG08_05005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ITG08_05030	COG1072	(Pantothenic acid kinase))
ITG08_05040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ITG08_05050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG08_05135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ITG08_05150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITG08_05165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG08_05170	COG0534	Mate efflux family protein
ITG08_05175	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ITG08_05180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ITG08_05185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITG08_05190	COG2937	Belongs to the GPAT DAPAT family
ITG08_05195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ITG08_05200	COG3161	chorismate lyase activity
ITG08_05205	COG1580	Controls the rotational direction of flagella during chemotaxis
ITG08_05215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG08_05225	COG2177	Part of the ABC transporter FtsEX involved in
ITG08_05230	COG2884	Cell division ATP-binding protein ftsE
ITG08_05235	COG0552	protein localization to endoplasmic reticulum
ITG08_05240	COG0742	ribosomal rna small subunit methyltransferase
ITG08_05250	COG2095	MarC family integral membrane protein
ITG08_05290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITG08_05295	COG0640	Transcriptional regulator
ITG08_05300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG08_05305	COG1280	lysine exporter protein (LysE YggA)
ITG08_05310	COG2267	carboxylic ester hydrolase activity
ITG08_05315	COG0561	phosphatase activity
ITG08_05330	COG3148	PFAM DTW domain containing protein
ITG08_05335	COG2199	diguanylate cyclase activity
ITG08_05335	COG2200	EAL domain
ITG08_05335	COG3287	FIST C domain
ITG08_05340	COG2199	diguanylate cyclase activity
ITG08_05340	COG2200	EAL domain
ITG08_05340	COG3287	FIST C domain
ITG08_05345	COG1011	Hydrolase
ITG08_05350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ITG08_05360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ITG08_05365	COG0019	diaminopimelate decarboxylase activity
ITG08_05375	COG1965	Belongs to the frataxin family
ITG08_05380	COG3072	Adenylate cyclase
ITG08_05385	COG0181	hydroxymethylbilane synthase activity
ITG08_05390	COG1587	Uroporphyrinogen-III synthase
ITG08_05395	COG2959	enzyme of heme biosynthesis
ITG08_05400	COG3071	HemY protein
ITG08_05460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ITG08_05475	COG3118	belongs to the thioredoxin family
ITG08_05480	COG0513	Belongs to the DEAD box helicase family
ITG08_05485	COG0248	Ppx GppA phosphatase
ITG08_05490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ITG08_05500	COG0514	ATP-dependent DNA helicase (RecQ)
ITG08_05505	COG2962	Rard protein
ITG08_05515	COG1280	lysine exporter protein (LysE YggA)
ITG08_05520	COG0405	Gamma-glutamyltransferase
ITG08_05530	COG0210	DNA helicase
ITG08_05540	COG3220	belongs to the UPF0276 family
ITG08_05560	COG2814	Major facilitator Superfamily
ITG08_05570	COG0006	proline dipeptidase activity
ITG08_05570	COG0006	proline dipeptidase activity
ITG08_05580	COG2022	thiamine diphosphate biosynthetic process
ITG08_05585	COG2104	thiamine diphosphate biosynthetic process
ITG08_05590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITG08_05595	COG0352	thiamine-phosphate diphosphorylase activity
ITG08_05600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ITG08_05610	COG2132	Multicopper oxidase
ITG08_05655	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ITG08_05660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG08_05665	COG1739	Uncharacterized protein family UPF0029
ITG08_05670	COG1024	Enoyl-CoA hydratase
ITG08_05670	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG08_05675	COG0183	Belongs to the thiolase family
ITG08_05680	COG0604	alcohol dehydrogenase
ITG08_05695	COG0425	Belongs to the sulfur carrier protein TusA family
ITG08_05705	COG2119	membrane
ITG08_05710	COG0752	glycyl-tRNA synthetase alpha subunit
ITG08_05715	COG0751	glycine-tRNA ligase activity
ITG08_05720	COG0366	Alpha amylase catalytic
ITG08_05725	COG3977	Valine--pyruvate aminotransferase
ITG08_05730	COG0071	Belongs to the small heat shock protein (HSP20) family
ITG08_05735	COG0187	DNA topoisomerase II activity
ITG08_05740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITG08_05745	COG0592	DNA-directed DNA polymerase activity
ITG08_05750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ITG08_05765	COG1126	abc transporter atp-binding protein
ITG08_05770	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ITG08_05775	COG0594	ribonuclease P activity
ITG08_05780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ITG08_05785	COG0706	membrane insertase activity
ITG08_05795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG08_05800	COG0445	tRNA wobble uridine modification
ITG08_05805	COG0357	Ribosomal RNA small subunit methyltransferase G
ITG08_05810	COG1192	Involved in chromosome partitioning
ITG08_05815	COG1475	DNA binding
ITG08_05820	COG3312	ion transport
ITG08_05835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ITG08_05840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG08_05845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ITG08_05850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG08_05855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ITG08_05860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG08_05870	COG2814	Major facilitator Superfamily
ITG08_05875	COG0583	DNA-binding transcription factor activity
ITG08_05885	COG0129	dihydroxy-acid dehydratase activity
ITG08_05890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITG08_05895	COG3978	acetolactate synthase activity
ITG08_05955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG08_05960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITG08_05970	COG3084	Protein conserved in bacteria
ITG08_05980	COG4326	sporulation control protein
ITG08_05985	COG1272	protein, Hemolysin III
ITG08_05995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG08_06000	COG0569	domain protein
ITG08_06005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITG08_06005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG08_06010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ITG08_06015	COG0242	peptide deformylase activity
ITG08_06025	COG0758	DNA mediated transformation
ITG08_06030	COG2922	Belongs to the Smg family
ITG08_06035	COG0551	DNA topoisomerase type I activity
ITG08_06040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ITG08_06045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ITG08_06050	COG0009	L-threonylcarbamoyladenylate synthase
ITG08_06055	COG0408	coproporphyrinogen oxidase activity
ITG08_06060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ITG08_06070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITG08_06115	COG0583	DNA-binding transcription factor activity
ITG08_06120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ITG08_06125	COG2960	long-chain fatty acid transporting porin activity
ITG08_06130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG08_06135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_06140	COG1309	transcriptional regulator
ITG08_06190	COG0601	transmembrane transport
ITG08_06195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITG08_06205	COG1805	sodium ion transport
ITG08_06215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITG08_06220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ITG08_06225	COG0339	signal peptide processing
ITG08_06230	COG1522	sequence-specific DNA binding
ITG08_06235	COG5001	Diguanylate cyclase
ITG08_06235	COG5002	protein histidine kinase activity
ITG08_06240	COG0742	ribosomal rna small subunit methyltransferase
ITG08_06255	COG0589	response to stress
ITG08_06260	COG1528	Iron-storage protein
ITG08_06270	COG2081	HI0933 family
ITG08_06280	COG1322	Protein conserved in bacteria
ITG08_06285	COG2226	methyltransferase
ITG08_06290	COG3165	ubiquinone biosynthetic process from chorismate
ITG08_06295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG08_06300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG08_06305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITG08_06310	COG0805	protein transport
ITG08_06315	COG0084	hydrolase, TatD family'
ITG08_06330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG08_06330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITG08_06355	COG3078	GTPase activator activity
ITG08_06375	COG2204	response regulator
ITG08_06380	COG3852	Histidine kinase
ITG08_06390	COG0174	glutamine synthetase
ITG08_06395	COG1217	gtp-binding protein TYPA
ITG08_06410	COG1295	ribonuclease BN
ITG08_06415	COG1490	D-aminoacyl-tRNA deacylase activity
ITG08_06420	COG0456	acetyltransferase
ITG08_06430	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ITG08_06440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ITG08_06445	COG3031	protein transport across the cell outer membrane
ITG08_06455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG08_06460	COG1459	type II secretion system
ITG08_06465	COG2165	general secretion pathway protein
ITG08_06470	COG2165	general secretion pathway protein
ITG08_06475	COG2165	general secretion pathway protein
ITG08_06480	COG4795	General secretion pathway protein
ITG08_06485	COG3156	type II secretion system protein K
ITG08_06490	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG08_06495	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ITG08_06505	COG1218	3'(2'),5'-bisphosphate nucleotidase
ITG08_06510	COG0494	nUDIX hydrolase
ITG08_06515	COG0316	Belongs to the HesB IscA family
ITG08_06515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ITG08_06520	COG1040	competence protein
ITG08_06525	COG0596	Alpha beta hydrolase
ITG08_06535	COG2183	response to ionizing radiation
ITG08_06540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG08_06555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ITG08_06560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITG08_06565	COG1758	RNA polymerase activity
ITG08_06570	COG0194	GDP metabolic process
ITG08_06575	COG2252	PERMEase
ITG08_06585	COG1278	Cold shock
ITG08_06650	COG1561	YicC-like family, N-terminal region
ITG08_06655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ITG08_06660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ITG08_06665	COG1560	Kdo2-lipid A biosynthetic process
ITG08_06670	COG1309	transcriptional regulator
ITG08_06680	COG2003	Belongs to the UPF0758 family
ITG08_06685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ITG08_06690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ITG08_06700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ITG08_06720	COG0859	PFAM glycosyl transferase family 9
ITG08_06725	COG3642	lipopolysaccharide core region biosynthetic process
ITG08_06730	COG1519	Transferase
ITG08_06740	COG0463	Glycosyl transferase, family 2
ITG08_06750	COG1083	cytidylyl-transferase
ITG08_06765	COG2089	acid synthase
ITG08_06770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ITG08_06775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITG08_06780	COG1086	Polysaccharide biosynthesis protein
ITG08_06800	COG1560	Kdo2-lipid A biosynthetic process
ITG08_06820	COG4942	peptidase
ITG08_06825	COG1045	serine acetyltransferase
ITG08_06835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ITG08_06840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG08_06885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITG08_06905	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG08_06910	COG1596	polysaccharide export
ITG08_06955	COG2244	polysaccharide biosynthetic process
ITG08_06960	COG1442	glycosyl transferase family 8
ITG08_06960	COG1216	Glycosyl transferase, family 2
ITG08_06975	COG1215	transferase activity, transferring glycosyl groups
ITG08_06990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG08_06995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG08_07000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ITG08_07015	COG0534	Mate efflux family protein
ITG08_07020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ITG08_07035	COG2199	diguanylate cyclase activity
ITG08_07040	COG2199	diguanylate cyclase activity
ITG08_07050	COG4251	negative regulation of phosphorylation
ITG08_07055	COG2197	response regulator
ITG08_07060	COG5001	Diguanylate cyclase
ITG08_07060	COG3300	MHYT domain
ITG08_07065	COG0840	transmembrane signaling receptor activity
ITG08_07075	COG5001	Diguanylate cyclase
ITG08_07080	COG1285	pathogenesis
ITG08_07085	COG1509	lysine 2,3-aminomutase activity
ITG08_07090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG08_07100	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ITG08_07105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITG08_07110	COG1053	succinate dehydrogenase
ITG08_07115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ITG08_07125	COG0840	transmembrane signaling receptor activity
ITG08_07130	COG0471	metal ion transport
ITG08_07130	COG0490	domain, Protein
ITG08_07140	COG1162	GTPase activity
ITG08_07235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ITG08_07240	COG0802	atpase or kinase
ITG08_07245	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITG08_07250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ITG08_07255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ITG08_07260	COG1923	regulation of RNA biosynthetic process
ITG08_07265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG08_07270	COG0330	HflC and HflK could
ITG08_07275	COG0330	HflC and HflK could
ITG08_07280	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ITG08_07285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG08_07290	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ITG08_07295	COG0402	S-adenosylhomocysteine deaminase activity
ITG08_07300	COG0557	exoribonuclease II activity
ITG08_07305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG08_07320	COG0359	binds to the 23S rRNA
ITG08_07335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITG08_07345	COG0432	Pfam Uncharacterised protein family UPF0047
ITG08_07350	COG0166	Belongs to the GPI family
ITG08_07360	COG0735	belongs to the Fur family
ITG08_07385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITG08_07390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG08_07395	COG0175	sulfate reduction
ITG08_07475	COG0646	methionine synthase
ITG08_07475	COG1410	methionine synthase
ITG08_07480	COG0527	aspartate kinase activity
ITG08_07485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITG08_07495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ITG08_07505	COG2197	response regulator
ITG08_07580	COG0629	single-stranded DNA binding
ITG08_07585	COG2199	diguanylate cyclase activity
ITG08_07585	COG2200	EAL domain
ITG08_07610	COG3267	Type II secretory pathway component ExeA
ITG08_07610	COG3409	Peptidoglycan-binding domain 1 protein
ITG08_07620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITG08_07625	COG1459	type II secretion system
ITG08_07635	COG2165	general secretion pathway protein
ITG08_07640	COG2165	general secretion pathway protein
ITG08_07670	COG1077	Cell shape determining protein MreB Mrl
ITG08_07675	COG1792	Involved in formation and maintenance of cell shape
ITG08_07680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ITG08_07685	COG0424	maF-like protein
ITG08_07700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITG08_07705	COG0312	modulator of DNA gyrase
ITG08_07710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ITG08_07715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITG08_07730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG08_07735	COG0589	response to stress
ITG08_07750	COG1438	arginine binding
ITG08_07755	COG0039	L-malate dehydrogenase activity
ITG08_07765	COG0142	geranyltranstransferase activity
ITG08_07770	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ITG08_07775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ITG08_07780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ITG08_07785	COG2966	Psort location CytoplasmicMembrane, score
ITG08_07790	COG3610	response to peptide
ITG08_07805	COG2967	ApaG domain
ITG08_07810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ITG08_07815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ITG08_07820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG08_07825	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ITG08_07830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG08_07845	COG0066	3-isopropylmalate dehydratase activity
ITG08_07855	COG0473	3-isopropylmalate dehydrogenase activity
ITG08_07860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITG08_07895	COG1022	Amp-dependent synthetase and ligase
ITG08_07900	COG0028	Belongs to the TPP enzyme family
ITG08_07910	COG3706	GGDEF domain
ITG08_07920	COG0469	pyruvate kinase activity
ITG08_07925	COG1349	DNA-binding transcription factor activity
ITG08_07930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ITG08_07935	COG2873	o-acetylhomoserine
ITG08_07955	COG1610	YqeY-like protein
ITG08_07960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ITG08_07965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ITG08_07970	COG0596	Alpha beta hydrolase
ITG08_07975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ITG08_07980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG08_07985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG08_07990	COG1968	undecaprenyl-diphosphatase activity
ITG08_07995	COG0617	tRNA 3'-terminal CCA addition
ITG08_08000	COG3267	Type II secretory pathway component ExeA
ITG08_08000	COG3409	Peptidoglycan-binding domain 1 protein
ITG08_08010	COG4991	sh3 domain protein
ITG08_08015	COG0306	phosphate transporter
ITG08_08020	COG1392	Phosphate transport regulator
ITG08_08025	COG3025	triphosphatase activity
ITG08_08030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITG08_08040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ITG08_08045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ITG08_08045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ITG08_08050	COG1538	Outer membrane efflux protein
ITG08_08055	COG0494	nUDIX hydrolase
ITG08_08060	COG3151	Protein conserved in bacteria
ITG08_08070	COG3150	esterase
ITG08_08085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG08_08090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITG08_08095	COG3105	Protein conserved in bacteria
ITG08_08100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ITG08_08105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ITG08_08110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ITG08_08115	COG0723	plastoquinol--plastocyanin reductase activity
ITG08_08120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITG08_08125	COG2857	Cytochrome c1
ITG08_08130	COG0625	glutathione transferase activity
ITG08_08135	COG2969	positive regulation of protein catabolic process
ITG08_08140	COG2823	Periplasmic or secreted lipoprotein
ITG08_08145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ITG08_08160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ITG08_08170	COG0275	rRNA processing
ITG08_08175	COG3116	cell division
ITG08_08180	COG0768	penicillin binding
ITG08_08185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITG08_08190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ITG08_08195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITG08_08200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ITG08_08205	COG0772	Belongs to the SEDS family
ITG08_08210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ITG08_08215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITG08_08220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ITG08_08225	COG0849	cell division
ITG08_08230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ITG08_08235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ITG08_08240	COG0653	protein targeting
ITG08_08245	COG0494	nUDIX hydrolase
ITG08_08250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ITG08_08255	COG0505	Belongs to the CarA family
ITG08_08260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITG08_08265	COG0730	response to heat
ITG08_08270	COG0583	DNA-binding transcription factor activity
ITG08_08275	COG2860	membrane
ITG08_08290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITG08_08300	COG0493	'glutamate synthase
ITG08_08305	COG0067	glutamate synthase
ITG08_08305	COG0069	glutamate synthase activity
ITG08_08305	COG0070	glutamate synthase
ITG08_08315	COG0067	glutamate synthase
ITG08_08315	COG0070	glutamate synthase
ITG08_08315	COG0069	glutamate synthase activity
ITG08_08320	COG1242	4 iron, 4 sulfur cluster binding
ITG08_08325	COG4251	negative regulation of phosphorylation
ITG08_08325	COG3706	GGDEF domain
ITG08_08325	COG2203	Gaf domain
ITG08_08325	COG5001	Diguanylate cyclase
ITG08_08330	COG0784	Response regulator, receiver
ITG08_08330	COG2198	Histidine kinase
ITG08_08330	COG5002	protein histidine kinase activity
ITG08_08340	COG0745	RESPONSE REGULATOR receiver
ITG08_08350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ITG08_08365	COG0083	homoserine kinase activity
ITG08_08370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ITG08_08375	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ITG08_08385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ITG08_08400	COG1115	amino acid carrier protein
ITG08_08405	COG3022	response to hydroperoxide
ITG08_08410	COG0513	Belongs to the DEAD box helicase family
ITG08_08415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ITG08_08425	COG0716	FMN binding
ITG08_08430	COG4974	Belongs to the 'phage' integrase family
ITG08_08435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITG08_08440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITG08_08450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ITG08_08455	COG3829	transcription factor binding
ITG08_08455	COG3290	protein histidine kinase activity
ITG08_08475	COG0494	nUDIX hydrolase
ITG08_08485	COG0730	response to heat
ITG08_08490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ITG08_08495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ITG08_08500	COG1283	sodium-dependent phosphate transmembrane transporter activity
ITG08_08505	COG0583	DNA-binding transcription factor activity
ITG08_08510	COG0640	Transcriptional regulator
ITG08_08515	COG0268	Binds directly to 16S ribosomal RNA
ITG08_08520	COG0728	peptidoglycan biosynthetic process
ITG08_08525	COG0196	riboflavin kinase activity
ITG08_08530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG08_08540	COG1047	Peptidyl-prolyl cis-trans
ITG08_08545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ITG08_08550	COG3279	Response regulator of the LytR AlgR family
ITG08_08555	COG3275	phosphorelay sensor kinase activity
ITG08_08560	COG1966	Carbon starvation protein
ITG08_08570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ITG08_08575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ITG08_08585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG08_08590	COG1605	Chorismate mutase
ITG08_08590	COG0287	Prephenate dehydrogenase
ITG08_08595	COG0739	heme binding
ITG08_08605	COG0488	(ABC) transporter
ITG08_08615	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ITG08_08620	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ITG08_08625	COG5001	Diguanylate cyclase
ITG08_08630	COG0077	Prephenate dehydratase
ITG08_08630	COG1605	Chorismate mutase
ITG08_08635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITG08_08640	COG0741	lytic transglycosylase activity
ITG08_08645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG08_08650	COG0564	pseudouridine synthase activity
ITG08_08695	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ITG08_08705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG08_08710	COG0826	peptidase U32
ITG08_08715	COG2974	May be involved in recombination
ITG08_08720	COG0745	RESPONSE REGULATOR receiver
ITG08_08725	COG5002	protein histidine kinase activity
ITG08_08735	COG0248	Ppx GppA phosphatase
ITG08_08740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ITG08_08750	COG0581	inorganic phosphate transmembrane transporter activity
ITG08_08755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG08_08760	COG0704	Plays a role in the regulation of phosphate uptake
ITG08_08780	COG3142	Participates in the control of copper homeostasis
ITG08_08785	COG0450	alkyl hydroperoxide reductase
ITG08_08790	COG0583	DNA-binding transcription factor activity
ITG08_08795	COG0840	transmembrane signaling receptor activity
ITG08_08800	COG0517	IMP dehydrogenase activity
ITG08_08805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ITG08_08810	COG0343	queuine tRNA-ribosyltransferase activity
ITG08_08815	COG1862	Preprotein translocase
ITG08_08820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG08_08825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG08_08830	COG0483	inositol monophosphate 1-phosphatase activity
ITG08_08835	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ITG08_08840	COG1959	2 iron, 2 sulfur cluster binding
ITG08_08845	COG1104	cysteine desulfurase activity
ITG08_08850	COG0822	iron-sulfur transferase activity
ITG08_08860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ITG08_08865	COG0443	Heat shock 70 kDa protein
ITG08_08875	COG2975	iron-sulfur cluster assembly
ITG08_08880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITG08_08885	COG0105	UTP biosynthetic process
ITG08_08890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ITG08_08895	COG1426	Protein conserved in bacteria
ITG08_08900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ITG08_08905	COG0124	histidyl-tRNA synthetase
ITG08_08910	COG2976	Protein conserved in bacteria
ITG08_08915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG08_08920	COG1160	GTP binding
ITG08_08925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ITG08_08930	COG3706	GGDEF domain
ITG08_08970	COG0831	urea catabolic process
ITG08_08975	COG0832	Belongs to the urease beta subunit family
ITG08_08980	COG0804	urea catabolic process
ITG08_08985	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ITG08_09000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ITG08_09005	COG1570	exodeoxyribonuclease VII activity
ITG08_09010	COG0516	GMP reductase activity
ITG08_09010	COG0517	IMP dehydrogenase activity
ITG08_09015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ITG08_09015	COG0519	Catalyzes the synthesis of GMP from XMP
ITG08_09025	COG1757	Na H antiporter
ITG08_09030	COG1584	GPR1 FUN34 yaaH family protein
ITG08_09035	COG1115	amino acid carrier protein
ITG08_09040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ITG08_09045	COG0204	Acyl-transferase
ITG08_09070	COG4067	protein conserved in archaea
ITG08_09070	COG0189	ligase activity
ITG08_09085	COG2867	negative regulation of translational initiation
ITG08_09090	COG2914	Belongs to the UPF0125 (RnfH) family
ITG08_09095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITG08_09100	COG0497	DNA recombination
ITG08_09105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ITG08_09110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ITG08_09115	COG1301	dicarboxylic acid transport
ITG08_09125	COG0443	Heat shock 70 kDa protein
ITG08_09130	COG0484	heat shock protein binding
ITG08_09160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ITG08_09165	COG1253	flavin adenine dinucleotide binding
ITG08_09180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITG08_09180	COG0047	phosphoribosylformylglycinamidine synthase activity
ITG08_09190	COG2171	N-acyltransferase activity
ITG08_09200	COG2095	MarC family integral membrane protein
ITG08_09215	COG3141	response to X-ray
ITG08_09230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ITG08_09235	COG1074	ATP-dependent DNA helicase activity
ITG08_09240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITG08_09250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ITG08_09250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITG08_09260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ITG08_09265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ITG08_09270	COG2166	iron-sulfur cluster assembly
ITG08_09275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG08_09280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITG08_09300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG08_09310	COG2813	Specifically methylates the guanine in position
ITG08_09315	COG0271	Belongs to the BolA IbaG family
ITG08_09320	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG08_09325	COG1805	sodium ion transport
ITG08_09335	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG08_09340	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ITG08_09345	COG2871	sodium ion transport
ITG08_09350	COG1477	protein flavinylation
ITG08_09355	COG2991	Protein conserved in bacteria
ITG08_09365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG08_09375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITG08_09385	COG0733	neurotransmitter:sodium symporter activity
ITG08_09390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ITG08_09395	COG0321	lipoyl(octanoyl) transferase activity
ITG08_09405	COG1686	Belongs to the peptidase S11 family
ITG08_09410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG08_09415	COG0772	Belongs to the SEDS family
ITG08_09420	COG0768	penicillin binding
ITG08_09425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ITG08_09430	COG0799	negative regulation of ribosome biogenesis
ITG08_09435	COG1466	dna polymerase III delta subunit
ITG08_09440	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ITG08_09445	COG0495	leucyl-tRNA aminoacylation
ITG08_09450	COG2888	peptidyl-tyrosine sulfation
ITG08_09455	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ITG08_09460	COG4535	Mg2 and Co2 transporter CorC
ITG08_09465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ITG08_09470	COG1702	phosphate starvation-inducible protein PhoH
ITG08_09480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITG08_09485	COG2706	6-phosphogluconolactonase activity
ITG08_09590	COG0193	aminoacyl-tRNA hydrolase activity
ITG08_09595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ITG08_09600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ITG08_09605	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ITG08_09610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ITG08_09615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ITG08_09620	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG08_09625	COG3094	Invasion gene expression up-regulator, SirB
ITG08_09630	COG2912	Transglutaminase-like superfamily
ITG08_09635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ITG08_09645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ITG08_09650	COG1187	pseudouridine synthase activity
ITG08_09655	COG2840	Smr protein MutS2
ITG08_09690	COG2217	Heavy metal translocating P-type atpase
ITG08_09690	COG2608	mercury ion transmembrane transporter activity
ITG08_09710	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_09750	COG1216	Glycosyl transferase, family 2
ITG08_09770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG08_09775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITG08_09835	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ITG08_09840	COG0784	Response regulator, receiver
ITG08_09840	COG0835	chemotaxis
ITG08_09845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ITG08_09850	COG1815	bacterial-type flagellum-dependent cell motility
ITG08_09855	COG1558	bacterial-type flagellum-dependent cell motility
ITG08_09865	COG1749	Flagellar hook protein flgE
ITG08_09870	COG4787	bacterial-type flagellum-dependent cell motility
ITG08_09880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ITG08_09885	COG1706	bacterial-type flagellum-dependent cell motility
ITG08_09890	COG1705	Flagellar rod assembly protein muramidase FlgJ
ITG08_09890	COG3951	Flagellar rod assembly protein muramidase FlgJ
ITG08_09905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG08_09910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG08_09915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITG08_09925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITG08_09935	COG1516	flagellar protein fliS
ITG08_09955	COG1677	Flagellar hook-basal body complex protein FliE
ITG08_09965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITG08_10015	COG1987	bacterial-type flagellum assembly
ITG08_10020	COG1684	flagellar biosynthetic protein fliR
ITG08_10055	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ITG08_10060	COG0784	Response regulator, receiver
ITG08_10060	COG0643	Histidine kinase
ITG08_10060	COG2198	Histidine kinase
ITG08_10065	COG2201	protein-glutamate methylesterase activity
ITG08_10070	COG1192	Involved in chromosome partitioning
ITG08_10080	COG0835	chemotaxis
ITG08_10090	COG4133	protoheme IX ABC transporter activity
ITG08_10095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG08_10100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG08_10105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITG08_10110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ITG08_10115	COG1138	Cytochrome C-type biogenesis protein
ITG08_10120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITG08_10130	COG3088	subunit of a heme lyase
ITG08_10130	COG4235	cytochrome complex assembly
ITG08_10135	COG2853	Lipoprotein
ITG08_10145	COG2067	long-chain fatty acid transport protein
ITG08_10160	COG0183	Belongs to the thiolase family
ITG08_10165	COG1024	Enoyl-CoA hydratase
ITG08_10165	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITG08_10175	COG2062	phosphohistidine phosphatase, SixA
ITG08_10180	COG2840	Smr protein MutS2
ITG08_10185	COG2890	protein-(glutamine-N5) methyltransferase activity
ITG08_10190	COG1280	lysine exporter protein (LysE YggA)
ITG08_10195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ITG08_10215	COG1175	transmembrane transport
ITG08_10225	COG3842	ATPase activity
ITG08_10230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITG08_10235	COG2070	2-Nitropropane dioxygenase
ITG08_10235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ITG08_10250	COG3321	synthase
ITG08_10250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG08_10265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG08_10270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG08_10275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG08_10300	COG0544	peptidyl-prolyl cis-trans isomerase activity
ITG08_10305	COG0740	serine-type endopeptidase activity
ITG08_10310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ITG08_10315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ITG08_10320	COG0776	regulation of translation
ITG08_10325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG08_10330	COG1555	photosystem II stabilization
ITG08_10345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ITG08_10350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ITG08_10355	COG0436	Aminotransferase
ITG08_10360	COG1169	isochorismate synthase
ITG08_10365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ITG08_10370	COG2267	carboxylic ester hydrolase activity
ITG08_10375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ITG08_10390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG08_10390	COG1263	PTS System
ITG08_10390	COG2190	(PTS) system
ITG08_10405	COG2855	membrane
ITG08_10470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG08_10480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITG08_10485	COG1522	sequence-specific DNA binding
ITG08_10495	COG1946	Acyl-CoA thioesterase
ITG08_10500	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ITG08_10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG08_10550	COG3341	Caulimovirus viroplasmin
ITG08_10550	COG0328	RNA-DNA hybrid ribonuclease activity
ITG08_10555	COG0438	transferase activity, transferring glycosyl groups
ITG08_10560	COG0463	Glycosyl transferase, family 2
ITG08_10560	COG1216	Glycosyl transferase, family 2
ITG08_10585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ITG08_10600	COG0789	Transcriptional regulator
ITG08_10625	COG3119	arylsulfatase activity
ITG08_10630	COG1609	Transcriptional regulator
ITG08_10645	COG2814	Major facilitator Superfamily
ITG08_10655	COG1760	l-serine dehydratase
ITG08_10660	COG1522	sequence-specific DNA binding
ITG08_10665	COG1280	lysine exporter protein (LysE YggA)
ITG08_10685	COG2233	PERMEase
ITG08_10705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITG08_10710	COG1227	inorganic diphosphatase activity
ITG08_10740	COG3152	Membrane
ITG08_10750	COG3547	Transposase (IS116 IS110 IS902 family)
ITG08_10770	COG1228	amidohydrolase
ITG08_10785	COG3040	lipid binding
ITG08_10800	COG0583	DNA-binding transcription factor activity
ITG08_10805	COG1309	transcriptional regulator
ITG08_10815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG08_10820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG08_10825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG08_10830	COG1845	cytochrome c oxidase, subunit III
ITG08_10835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITG08_10860	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG08_10880	COG0346	lactoylglutathione lyase activity
ITG08_10885	COG1902	pentaerythritol trinitrate reductase activity
ITG08_10895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG08_10920	COG0517	IMP dehydrogenase activity
ITG08_10920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ITG08_10920	COG0617	tRNA 3'-terminal CCA addition
ITG08_10950	COG0537	adenosine 5'-monophosphoramidase activity
ITG08_10975	COG3150	esterase
ITG08_10980	COG1252	NADH dehydrogenase
ITG08_10985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG08_10995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ITG08_11005	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG08_11010	COG1136	(ABC) transporter
ITG08_11015	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG08_11025	COG0658	competence protein
ITG08_11025	COG2333	competence protein COMEC
ITG08_11030	COG1132	(ABC) transporter
ITG08_11035	COG1663	tetraacyldisaccharide 4'-kinase activity
ITG08_11040	COG2835	tetraacyldisaccharide 4'-kinase activity
ITG08_11045	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ITG08_11050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ITG08_11055	COG0539	negative regulation of cytoplasmic translation
ITG08_11060	COG0776	regulation of translation
ITG08_11065	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ITG08_11070	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ITG08_11075	COG0284	orotidine-5'-phosphate decarboxylase activity
ITG08_11090	COG0583	DNA-binding transcription factor activity
ITG08_11100	COG0686	Belongs to the AlaDH PNT family
ITG08_11105	COG1522	sequence-specific DNA binding
ITG08_11115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ITG08_11120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ITG08_11125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ITG08_11130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ITG08_11135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITG08_11140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ITG08_11145	COG0156	8-amino-7-oxononanoate synthase activity
ITG08_11165	COG0501	Belongs to the peptidase M48B family
ITG08_11170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ITG08_11175	COG2915	High frequency lysogenization protein hflD homolog
ITG08_11190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG08_11195	COG2916	Histone family protein nucleoid-structuring protein H-NS
ITG08_11200	COG1757	Na H antiporter
ITG08_11215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG08_11220	COG0131	Imidazoleglycerol-phosphate dehydratase
ITG08_11220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ITG08_11225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ITG08_11230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ITG08_11235	COG0107	imidazoleglycerol-phosphate synthase activity
ITG08_11240	COG0140	phosphoribosyl-ATP diphosphatase activity
ITG08_11240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ITG08_11245	COG3012	SEC-C Motif Domain Protein
ITG08_11250	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITG08_11255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ITG08_11260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITG08_11265	COG0215	cysteine-tRNA ligase activity
ITG08_11295	COG2116	formate transmembrane transporter activity
ITG08_11300	COG0390	transport system, permease component
ITG08_11305	COG4459	periplasmic nitrate reductase
ITG08_11310	COG3005	denitrification pathway
ITG08_11315	COG0243	molybdopterin cofactor binding
ITG08_11325	COG1227	inorganic diphosphatase activity
ITG08_11340	COG4172	Belongs to the ABC transporter superfamily
ITG08_11350	COG4171	peptide transport system, permease
ITG08_11355	COG4168	peptide transport system, permease
ITG08_11360	COG4166	transmembrane transport
ITG08_11365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITG08_11370	COG1842	Phage shock protein A
ITG08_11380	COG1983	PspC domain protein
ITG08_11385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_11400	COG2818	Glycosylase
ITG08_11405	COG0626	cystathionine gamma-synthase activity
ITG08_11415	COG0733	neurotransmitter:sodium symporter activity
ITG08_11425	COG0564	pseudouridine synthase activity
ITG08_11430	COG0116	Belongs to the methyltransferase superfamily
ITG08_11430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG08_11435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ITG08_11440	COG4136	ATPase activity
ITG08_11445	COG4135	transport system, permease component
ITG08_11450	COG4134	Bacterial extracellular solute-binding protein
ITG08_11460	COG3313	Fe-S protein
ITG08_11480	COG0513	Belongs to the DEAD box helicase family
ITG08_11490	COG2866	Carboxypeptidase
ITG08_11515	COG4176	ABC-type proline glycine betaine transport system permease component
ITG08_11520	COG2113	Glycine betaine
ITG08_11610	COG3547	Transposase (IS116 IS110 IS902 family)
ITG08_11625	COG3547	Transposase (IS116 IS110 IS902 family)
ITG08_11655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ITG08_11675	COG0642	Histidine kinase
ITG08_11690	COG1061	Type III restriction enzyme res subunit
ITG08_11700	COG2814	Major facilitator Superfamily
ITG08_11710	COG0702	epimerase
ITG08_11735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ITG08_11740	COG2885	chlorophyll binding
ITG08_11740	COG3047	cAMP biosynthetic process
ITG08_11760	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG08_11765	COG2985	domain, Protein
ITG08_11765	COG3273	potassium ion transport
ITG08_11770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITG08_11780	COG1737	Transcriptional regulator
ITG08_11785	COG0076	glutamate decarboxylase activity
ITG08_11795	COG2431	L-lysine efflux transmembrane transporter activity
ITG08_11805	COG3070	regulator of competence-specific genes
ITG08_11815	COG2204	response regulator
ITG08_11820	COG3852	Histidine kinase
ITG08_11830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ITG08_11840	COG2258	MOSC domain
ITG08_11870	COG1448	Aminotransferase
ITG08_11875	COG2770	Histidine kinase
ITG08_11875	COG3437	response regulator, receiver
ITG08_11885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG08_11895	COG0017	Asparaginyl-tRNA synthetase
ITG08_11900	COG0659	secondary active sulfate transmembrane transporter activity
ITG08_11905	COG0840	transmembrane signaling receptor activity
ITG08_11910	COG0720	synthase
ITG08_11920	COG0814	amino acid
ITG08_11925	COG1760	l-serine dehydratase
ITG08_11930	COG0814	amino acid
ITG08_11935	COG0494	nUDIX hydrolase
ITG08_11950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG08_11965	COG3106	COG3106 Predicted ATPase
ITG08_11980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG08_11995	COG0443	Heat shock 70 kDa protein
ITG08_12010	COG3706	GGDEF domain
ITG08_12030	COG3710	Transcriptional regulator
ITG08_12060	COG1643	Atp-dependent helicase
ITG08_12105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ITG08_12110	COG0072	phenylalanine-tRNA ligase activity
ITG08_12110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITG08_12160	COG1595	DNA-templated transcription, initiation
ITG08_12180	COG1464	Belongs to the NlpA lipoprotein family
ITG08_12185	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ITG08_12190	COG3683	transport system, periplasmic component
ITG08_12205	COG1342	Belongs to the UPF0251 family
ITG08_12240	COG0776	regulation of translation
ITG08_12280	COG0583	DNA-binding transcription factor activity
ITG08_12305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG08_12315	COG2988	succinylglutamate desuccinylase activity
ITG08_12320	COG0523	cobalamin synthesis protein
ITG08_12330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITG08_12340	COG0776	regulation of translation
ITG08_12350	COG0500	methyltransferase
ITG08_12355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ITG08_12360	COG0295	cytidine deaminase activity
ITG08_12365	COG1346	cytolysis
ITG08_12375	COG2925	Exonuclease
ITG08_12420	COG3568	Endonuclease Exonuclease Phosphatase
ITG08_12425	COG3122	Protein conserved in bacteria
ITG08_12440	COG4989	oxidoreductase activity
ITG08_12450	COG1823	symporter activity
ITG08_12455	COG0702	epimerase
ITG08_12460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ITG08_12465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ITG08_12470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ITG08_12490	COG2988	succinylglutamate desuccinylase activity
ITG08_12495	COG4139	cobalamin transport
ITG08_12500	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ITG08_12550	COG1247	-acetyltransferase
ITG08_12560	COG3706	GGDEF domain
ITG08_12570	COG2814	Major facilitator Superfamily
ITG08_12580	COG0583	DNA-binding transcription factor activity
ITG08_12590	COG1451	nucleotide metabolic process
ITG08_12600	COG3063	Type IV pilus biogenesis stability protein PilW
ITG08_12605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ITG08_12620	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG08_12625	COG3706	GGDEF domain
ITG08_12685	COG2815	serine threonine protein kinase
ITG08_12685	COG0515	serine threonine protein kinase
ITG08_12695	COG1401	restriction endodeoxyribonuclease activity
ITG08_12710	COG0583	DNA-binding transcription factor activity
ITG08_12730	COG4964	Belongs to the GSP D family
ITG08_12740	COG0455	bacterial-type flagellum organization
ITG08_12785	COG5002	protein histidine kinase activity
ITG08_12785	COG5001	Diguanylate cyclase
ITG08_12790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ITG08_12795	COG0583	DNA-binding transcription factor activity
ITG08_12810	COG0840	transmembrane signaling receptor activity
ITG08_12820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG08_12825	COG1482	cell wall glycoprotein biosynthetic process
ITG08_12830	COG0246	Mannitol dehydrogenase
ITG08_12835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_12840	COG1312	Catalyzes the dehydration of D-mannonate
ITG08_12845	COG0110	maltose O-acetyltransferase activity
ITG08_12855	COG2186	Transcriptional regulator
ITG08_12870	COG3469	chitinase activity
ITG08_12880	COG4771	TonB-dependent receptor
ITG08_12890	COG0454	-acetyltransferase
ITG08_12905	COG0346	lactoylglutathione lyase activity
ITG08_12910	COG0420	3'-5' exonuclease activity
ITG08_12915	COG0419	ATPase involved in DNA repair
ITG08_12935	COG3046	protein related to deoxyribodipyrimidine photolyase
ITG08_12940	COG0415	Belongs to the DNA photolyase family
ITG08_12960	COG2977	Belongs to the P-Pant transferase superfamily
ITG08_12965	COG1120	ATPase activity
ITG08_12970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG08_12980	COG4615	Cyclic peptide transporter
ITG08_13000	COG4774	siderophore transport
ITG08_13030	COG2271	Major facilitator Superfamily
ITG08_13035	COG0584	glycerophosphoryl diester phosphodiesterase
ITG08_13055	COG0494	nUDIX hydrolase
ITG08_13070	COG1187	pseudouridine synthase activity
ITG08_13115	COG0653	protein targeting
ITG08_13125	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_13155	COG0826	peptidase U32
ITG08_13170	COG1126	abc transporter atp-binding protein
ITG08_13175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG08_13180	COG4215	(ABC) transporter
ITG08_13185	COG4160	amino acid transport
ITG08_13320	COG1742	UPF0060 membrane protein
ITG08_13340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ITG08_13350	COG0583	DNA-binding transcription factor activity
ITG08_13355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_13385	COG0583	DNA-binding transcription factor activity
ITG08_13415	COG2204	response regulator
ITG08_13425	COG3448	diguanylate cyclase activity
ITG08_13425	COG4175	Glycine betaine
ITG08_13430	COG4176	ABC-type proline glycine betaine transport system permease component
ITG08_13440	COG1793	dna ligase
ITG08_13445	COG0534	Mate efflux family protein
ITG08_13450	COG0307	riboflavin synthase, alpha
ITG08_13460	COG3001	Fructosamine kinase
ITG08_13470	COG0791	NLP P60 protein
ITG08_13485	COG3148	PFAM DTW domain containing protein
ITG08_13490	COG1940	carbohydrate kinase activity
ITG08_13500	COG0303	'Molybdopterin
ITG08_13505	COG0746	molybdenum cofactor guanylyltransferase activity
ITG08_13510	COG3842	ATPase activity
ITG08_13515	COG4662	Binding-protein-dependent transport system inner membrane component
ITG08_13530	COG4191	Histidine kinase
ITG08_13550	COG0488	(ABC) transporter
ITG08_13555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ITG08_13575	COG3381	protein complex oligomerization
ITG08_13585	COG3383	formate dehydrogenase (NAD+) activity
ITG08_13585	COG0243	molybdopterin cofactor binding
ITG08_13590	COG0437	4 iron, 4 sulfur cluster binding
ITG08_13605	COG0004	ammonium transporteR
ITG08_13610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ITG08_13615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ITG08_13625	COG1177	transmembrane transport
ITG08_13630	COG1176	ABC-type spermidine putrescine transport system, permease component I
ITG08_13635	COG3842	ATPase activity
ITG08_13660	COG0589	response to stress
ITG08_13665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITG08_13680	COG2217	Heavy metal translocating P-type atpase
ITG08_13690	COG2010	Cytochrome c
ITG08_13705	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG08_13820	COG3120	sequence-specific DNA binding
ITG08_13825	COG1067	ATP-dependent peptidase activity
ITG08_13845	COG0488	(ABC) transporter
ITG08_13855	COG0116	Belongs to the methyltransferase superfamily
ITG08_13855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG08_13865	COG0167	dihydroorotate dehydrogenase activity
ITG08_13870	COG2902	Dehydrogenase
ITG08_13880	COG0308	aminopeptidase N
ITG08_13895	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ITG08_13900	COG1956	GAF domain-containing protein
ITG08_13905	COG1132	(ABC) transporter
ITG08_13910	COG2995	paraquat-inducible protein a
ITG08_13915	COG3008	intermembrane lipid transfer
ITG08_13920	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ITG08_13920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITG08_13925	COG2996	Protein conserved in bacteria
ITG08_13940	COG0574	Belongs to the PEP-utilizing enzyme family
ITG08_13940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITG08_13945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG08_13950	COG1666	GTP binding
ITG08_13960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG08_13965	COG4597	amino acid ABC transporter
ITG08_13970	COG0765	amino acid transport
ITG08_13975	COG1126	abc transporter atp-binding protein
ITG08_13980	COG0670	Belongs to the BI1 family
ITG08_13985	COG2920	part of a sulfur-relay system
ITG08_13990	COG1254	Belongs to the acylphosphatase family
ITG08_14000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITG08_14015	COG3047	cAMP biosynthetic process
ITG08_14015	COG2885	chlorophyll binding
ITG08_14025	COG3706	GGDEF domain
ITG08_14030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ITG08_14035	COG0602	queuosine metabolic process
ITG08_14040	COG0561	phosphatase activity
ITG08_14070	COG2828	Protein conserved in bacteria
ITG08_14075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ITG08_14080	COG0372	Belongs to the citrate synthase family
ITG08_14085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ITG08_14125	COG4628	conserved protein (DUF2132)
ITG08_14135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG08_14140	COG0363	glucosamine-6-phosphate deaminase activity
ITG08_14145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ITG08_14150	COG4565	transcriptional regulatory protein
ITG08_14155	COG3290	protein histidine kinase activity
ITG08_14170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_14185	COG1115	amino acid carrier protein
ITG08_14205	COG1115	amino acid carrier protein
ITG08_14210	COG1280	lysine exporter protein (LysE YggA)
ITG08_14215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ITG08_14225	COG0730	response to heat
ITG08_14270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG08_14270	COG4191	Histidine kinase
ITG08_14275	COG0471	metal ion transport
ITG08_14315	COG3033	Beta-eliminating lyase
ITG08_14340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_14350	COG0840	transmembrane signaling receptor activity
ITG08_14360	COG2176	DNA-directed DNA polymerase activity
ITG08_14365	COG0517	IMP dehydrogenase activity
ITG08_14370	COG2186	Transcriptional regulator
ITG08_14375	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_14380	COG2186	Transcriptional regulator
ITG08_14415	COG0840	transmembrane signaling receptor activity
ITG08_14430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_14440	COG3181	Tripartite tricarboxylate transporter family receptor
ITG08_14455	COG2186	Transcriptional regulator
ITG08_14465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG08_14470	COG3639	organic phosphonate transmembrane transporter activity
ITG08_14495	COG1917	Cupin 2, conserved barrel domain protein
ITG08_14500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG08_14505	COG0800	Aldolase
ITG08_14510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_14515	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ITG08_14525	COG0010	Belongs to the arginase family
ITG08_14530	COG1166	arginine decarboxylase activity
ITG08_14540	COG1309	transcriptional regulator
ITG08_14545	COG0488	(ABC) transporter
ITG08_14560	COG3097	Belongs to the UPF0267 family
ITG08_14565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ITG08_14570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ITG08_14590	COG4326	sporulation control protein
ITG08_14600	COG1228	amidohydrolase
ITG08_14605	COG0010	Belongs to the arginase family
ITG08_14610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ITG08_14615	COG2986	histidine ammonia-lyase
ITG08_14635	COG0247	lactate metabolic process
ITG08_14635	COG0277	FAD linked oxidase domain protein
ITG08_14670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ITG08_14680	COG1643	Atp-dependent helicase
ITG08_14685	COG0281	malic enzyme
ITG08_14690	COG2949	membrane
ITG08_14695	COG0471	metal ion transport
ITG08_14710	COG2203	Gaf domain
ITG08_14710	COG2199	diguanylate cyclase activity
ITG08_14725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITG08_14735	COG3706	GGDEF domain
ITG08_14740	COG0492	ferredoxin-NADP+ reductase activity
ITG08_14745	COG4988	ABC transporter
ITG08_14750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ITG08_14755	COG0840	transmembrane signaling receptor activity
ITG08_14760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG08_14765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG08_14790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ITG08_14805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITG08_14810	COG3108	Peptidase M15
ITG08_14815	COG2989	Protein conserved in bacteria
ITG08_14840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG08_14850	COG4235	cytochrome complex assembly
ITG08_14850	COG3088	subunit of a heme lyase
ITG08_14860	COG1138	Cytochrome C-type biogenesis protein
ITG08_14865	COG3301	Polysulphide reductase, NrfD
ITG08_14870	COG0437	4 iron, 4 sulfur cluster binding
ITG08_14875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ITG08_14880	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ITG08_14885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITG08_14900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG08_14905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG08_14910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITG08_14930	COG0243	molybdopterin cofactor binding
ITG08_14935	COG0437	4 iron, 4 sulfur cluster binding
ITG08_14940	COG3302	dmso reductase anchor subunit
ITG08_14960	COG0019	diaminopimelate decarboxylase activity
ITG08_15000	COG0322	excinuclease ABC activity
ITG08_15005	COG2197	response regulator
ITG08_15010	COG0417	DNA replication proofreading
ITG08_15020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITG08_15035	COG1187	pseudouridine synthase activity
ITG08_15040	COG0009	L-threonylcarbamoyladenylate synthase
ITG08_15045	COG0613	PHP domain protein
ITG08_15055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITG08_15060	COG0512	Glutamine amidotransferase of anthranilate synthase
ITG08_15065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ITG08_15070	COG0134	indole-3-glycerol-phosphate synthase activity
ITG08_15070	COG0135	phosphoribosylanthranilate isomerase activity
ITG08_15075	COG0133	tryptophan synthase activity
ITG08_15080	COG0159	tryptophan synthase activity
ITG08_15085	COG1301	dicarboxylic acid transport
ITG08_15095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG08_15105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG08_15110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITG08_15125	COG2917	probably involved in intracellular septation
ITG08_15130	COG1607	acyl-coa hydrolase
ITG08_15135	COG2350	Protein conserved in bacteria
ITG08_15145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITG08_15150	COG0583	DNA-binding transcription factor activity
ITG08_15165	COG1032	radical SAM domain protein
ITG08_15170	COG1396	sequence-specific DNA binding
ITG08_15175	COG3135	benzoate transporter
ITG08_15190	COG0463	Glycosyl transferase, family 2
ITG08_15200	COG3547	Transposase (IS116 IS110 IS902 family)
ITG08_15210	COG1901	pseudouridine methyltransferase
ITG08_15225	COG1595	DNA-templated transcription, initiation
ITG08_15230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITG08_15255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG08_15265	COG0583	DNA-binding transcription factor activity
ITG08_15270	COG2910	NAD(P)H-binding
ITG08_15280	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_15285	COG1733	regulation of RNA biosynthetic process
ITG08_15290	COG0583	DNA-binding transcription factor activity
ITG08_15295	COG4221	oxidoreductase activity
ITG08_15305	COG3047	cAMP biosynthetic process
ITG08_15310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITG08_15325	COG3639	organic phosphonate transmembrane transporter activity
ITG08_15330	COG3639	organic phosphonate transmembrane transporter activity
ITG08_15335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ITG08_15360	COG4948	Mandelate Racemase Muconate Lactonizing
ITG08_15370	COG0583	DNA-binding transcription factor activity
ITG08_15390	COG0583	DNA-binding transcription factor activity
ITG08_15400	COG0840	transmembrane signaling receptor activity
ITG08_15415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG08_15430	COG2814	Major facilitator Superfamily
ITG08_15435	COG0814	amino acid
ITG08_15445	COG1012	belongs to the aldehyde dehydrogenase family
ITG08_15455	COG0840	transmembrane signaling receptor activity
ITG08_15470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_15475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_15485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_15490	COG2207	Transcriptional regulator
ITG08_15495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_15495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_15495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_15510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_15525	COG4166	transmembrane transport
ITG08_15545	COG3119	arylsulfatase activity
ITG08_15555	COG0641	radical SAM
ITG08_15570	COG0697	spore germination
ITG08_15575	COG0431	NADPH-dependent FMN reductase
ITG08_15585	COG0302	gtp cyclohydrolase
ITG08_15590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITG08_15595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITG08_15620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ITG08_15635	COG1012	belongs to the aldehyde dehydrogenase family
ITG08_15640	COG3284	Transcriptional regulator
ITG08_15645	COG0415	Belongs to the DNA photolyase family
ITG08_15650	COG0583	DNA-binding transcription factor activity
ITG08_15660	COG1621	beta-fructofuranosidase activity
ITG08_15665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG08_15670	COG1263	PTS System
ITG08_15670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITG08_15710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ITG08_15715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG08_15720	COG1418	mRNA catabolic process
ITG08_15730	COG2186	Transcriptional regulator
ITG08_15740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ITG08_15750	COG0402	S-adenosylhomocysteine deaminase activity
ITG08_15760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ITG08_15765	COG0789	Transcriptional regulator
ITG08_15780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ITG08_15800	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
ITG08_15805	COG4266	Belongs to the allantoicase family
ITG08_15825	COG2252	PERMEase
ITG08_15850	COG0402	S-adenosylhomocysteine deaminase activity
ITG08_15865	COG2084	Dehydrogenase
ITG08_15870	COG3622	Belongs to the hyi family
ITG08_15875	COG3960	tartronate-semialdehyde synthase activity
ITG08_15880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ITG08_15890	COG2259	Doxx family
ITG08_15895	COG1846	Transcriptional regulator
ITG08_15945	COG1067	ATP-dependent peptidase activity
ITG08_15955	COG4172	Belongs to the ABC transporter superfamily
ITG08_15960	COG1609	Transcriptional regulator
ITG08_15970	COG2017	converts alpha-aldose to the beta-anomer
ITG08_15975	COG3459	Glycosyltransferase 36 associated
ITG08_15980	COG3842	ATPase activity
ITG08_15985	COG2723	6-phospho-beta-galactosidase activity
ITG08_15990	COG0395	ABC-type sugar transport system, permease component
ITG08_16020	COG1505	serine-type exopeptidase activity
ITG08_16025	COG0583	DNA-binding transcription factor activity
ITG08_16030	COG1620	l-lactate permease
ITG08_16035	COG1304	FMN binding
ITG08_16055	COG0747	negative chemotaxis
ITG08_16060	COG4172	Belongs to the ABC transporter superfamily
ITG08_16070	COG0534	Mate efflux family protein
ITG08_16075	COG2207	Transcriptional regulator
ITG08_16075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITG08_16080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG08_16095	COG1054	Belongs to the UPF0176 family
ITG08_16110	COG1482	cell wall glycoprotein biosynthetic process
ITG08_16115	COG2271	Major facilitator Superfamily
ITG08_16120	COG3851	Histidine kinase
ITG08_16125	COG2197	response regulator
ITG08_16155	COG1741	Belongs to the pirin family
ITG08_16160	COG3123	guanosine phosphorylase activity
ITG08_16175	COG0596	Alpha beta hydrolase
ITG08_16215	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ITG08_16225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ITG08_16240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITG08_16260	COG0363	glucosamine-6-phosphate deaminase activity
ITG08_16265	COG3722	fumarate hydratase activity
ITG08_16270	COG0246	Mannitol dehydrogenase
ITG08_16275	COG2213	PTS system mannitol-specific
ITG08_16275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_16300	COG0786	glutamate:sodium symporter activity
ITG08_16315	COG1942	4-Oxalocrotonate Tautomerase
ITG08_16325	COG1595	DNA-templated transcription, initiation
ITG08_16330	COG3806	Anti-sigma factor
ITG08_16340	COG0415	Belongs to the DNA photolyase family
ITG08_16365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ITG08_16390	COG4221	oxidoreductase activity
ITG08_16395	COG0724	RNA recognition motif
ITG08_16405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITG08_16425	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_16430	COG2814	Major facilitator Superfamily
ITG08_16450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG08_16455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITG08_16465	COG0612	Peptidase, M16
ITG08_16470	COG3279	Response regulator of the LytR AlgR family
ITG08_16475	COG3275	phosphorelay sensor kinase activity
ITG08_16490	COG4591	ABC-type transport system involved in lipoprotein release permease component
ITG08_16515	COG0583	DNA-binding transcription factor activity
ITG08_16535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITG08_16540	COG2084	Dehydrogenase
ITG08_16555	COG0217	transcriptional regulatory protein
ITG08_16570	COG3186	Phenylalanine-4-hydroxylase
ITG08_16575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITG08_16585	COG0625	glutathione transferase activity
ITG08_16595	COG0583	DNA-binding transcription factor activity
ITG08_16600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITG08_16600	COG4221	oxidoreductase activity
ITG08_16600	COG3321	synthase
ITG08_16600	COG0604	alcohol dehydrogenase
ITG08_16620	COG0625	glutathione transferase activity
ITG08_16630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ITG08_16650	COG2205	protein histidine kinase activity
ITG08_16655	COG0745	RESPONSE REGULATOR receiver
ITG08_16665	COG3842	ATPase activity
ITG08_16700	COG0765	amino acid transport
ITG08_16715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITG08_16730	COG4221	oxidoreductase activity
ITG08_16745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITG08_16745	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ITG08_16775	COG1444	tRNA N-acetyltransferase activity
ITG08_16815	COG0259	pyridoxamine-phosphate oxidase activity
ITG08_16850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_16870	COG4399	Belongs to the UPF0754 family
ITG08_16875	COG1132	(ABC) transporter
ITG08_16900	COG2194	sulfuric ester hydrolase activity
ITG08_16930	COG3852	Histidine kinase
ITG08_16935	COG2204	response regulator
ITG08_16950	COG0579	oxidoreductase
ITG08_16970	COG2205	protein histidine kinase activity
ITG08_16975	COG0745	RESPONSE REGULATOR receiver
ITG08_16985	COG1309	transcriptional regulator
ITG08_16990	COG1012	belongs to the aldehyde dehydrogenase family
ITG08_17010	COG4175	Glycine betaine
ITG08_17010	COG0517	IMP dehydrogenase activity
ITG08_17015	COG1846	Transcriptional regulator
ITG08_17050	COG1309	transcriptional regulator
ITG08_17070	COG0456	acetyltransferase
ITG08_17075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG08_17085	COG0527	aspartate kinase activity
ITG08_17115	COG1803	Methylglyoxal synthase
ITG08_17115	COG1597	lipid kinase activity
ITG08_17120	COG0668	transmembrane transport
ITG08_17145	COG0628	permease
ITG08_17155	COG0110	maltose O-acetyltransferase activity
ITG08_17160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG08_17180	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_17180	COG3321	synthase
ITG08_17180	COG0604	alcohol dehydrogenase
ITG08_17215	COG0300	oxidoreductase activity
ITG08_17220	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ITG08_17235	COG0346	lactoylglutathione lyase activity
ITG08_17245	COG2723	6-phospho-beta-galactosidase activity
ITG08_17250	COG1609	Transcriptional regulator
ITG08_17255	COG0110	maltose O-acetyltransferase activity
ITG08_17295	COG2814	Major facilitator Superfamily
ITG08_17300	COG0583	DNA-binding transcription factor activity
ITG08_17320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG08_17335	COG1794	racemase activity, acting on amino acids and derivatives
ITG08_17345	COG0583	DNA-binding transcription factor activity
ITG08_17350	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_17355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ITG08_17360	COG1349	DNA-binding transcription factor activity
ITG08_17365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ITG08_17370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITG08_17380	COG0583	DNA-binding transcription factor activity
ITG08_17385	COG0798	PFAM Bile acid sodium symporter
ITG08_17400	COG1309	transcriptional regulator
ITG08_17415	COG0561	phosphatase activity
ITG08_17425	COG3214	Protein conserved in bacteria
ITG08_17430	COG0583	DNA-binding transcription factor activity
ITG08_17455	COG1349	DNA-binding transcription factor activity
ITG08_17460	COG2084	Dehydrogenase
ITG08_17465	COG3395	kinase activity
ITG08_17470	COG0235	Class ii aldolase
ITG08_17475	COG3622	Belongs to the hyi family
ITG08_17480	COG2610	gluconate transmembrane transporter activity
ITG08_17485	COG1929	Belongs to the glycerate kinase type-1 family
ITG08_17490	COG0753	catalase activity
ITG08_17495	COG4667	esterase of the alpha-beta hydrolase superfamily
ITG08_17500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITG08_17510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG08_17515	COG0204	Acyl-transferase
ITG08_17550	COG0366	Alpha amylase catalytic
ITG08_17590	COG3258	Cytochrome c
ITG08_17630	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ITG08_17640	COG1999	signal sequence binding
ITG08_17660	COG0058	SHG alpha-glucan phosphorylase activity
ITG08_17665	COG1640	4-alpha-glucanotransferase
ITG08_17670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ITG08_17685	COG1122	ATPase activity
ITG08_17690	COG4720	Psort location CytoplasmicMembrane, score
ITG08_17695	COG1566	PFAM secretion protein HlyD family protein
ITG08_17725	COG0813	purine-nucleoside phosphorylase activity
ITG08_17730	COG1376	ErfK ybiS ycfS ynhG family protein
ITG08_17730	COG1388	LysM domain
ITG08_17740	COG0513	Belongs to the DEAD box helicase family
ITG08_17745	COG3240	lipase activity
ITG08_17750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITG08_17765	COG4771	TonB-dependent receptor
ITG08_17785	COG0840	transmembrane signaling receptor activity
ITG08_17795	COG0573	inorganic phosphate transmembrane transporter activity
ITG08_17800	COG0581	inorganic phosphate transmembrane transporter activity
ITG08_17805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITG08_17810	COG3706	GGDEF domain
ITG08_17820	COG2304	oxidoreductase activity
ITG08_17825	COG2304	oxidoreductase activity
ITG08_17840	COG0714	Associated with various cellular activities
ITG08_17845	COG0840	transmembrane signaling receptor activity
ITG08_17855	COG3842	ATPase activity
ITG08_17865	COG1175	transmembrane transport
ITG08_17870	COG3833	ABC-type maltose transport systems, permease component
ITG08_17900	COG2814	Major facilitator Superfamily
ITG08_17915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG08_17920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_17925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_17930	COG0577	efflux transmembrane transporter activity
ITG08_17930	COG1136	(ABC) transporter
ITG08_17935	COG2205	protein histidine kinase activity
ITG08_17940	COG0745	RESPONSE REGULATOR receiver
ITG08_17950	COG0577	efflux transmembrane transporter activity
ITG08_17955	COG1136	(ABC) transporter
ITG08_17970	COG0698	ribose 5-phosphate isomerase
ITG08_17975	COG0697	spore germination
ITG08_18005	COG1028	Short-chain dehydrogenase reductase Sdr
ITG08_18025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITG08_18030	COG1904	glucuronate isomerase
ITG08_18070	COG4934	collagen metabolic process
ITG08_18100	COG1012	belongs to the aldehyde dehydrogenase family
ITG08_18105	COG1414	Transcriptional regulator
ITG08_18110	COG0280	phosphate acetyltransferase
ITG08_18115	COG0730	response to heat
ITG08_18145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG08_18150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITG08_18155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG08_18160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG08_18160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ITG08_18175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG08_18185	COG2354	Protein conserved in bacteria
ITG08_18190	COG0418	dihydroorotase activity
ITG08_18200	COG3217	Mosc domain protein beta barrel domain protein
ITG08_18200	COG0633	Ferredoxin
ITG08_18205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ITG08_18250	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ITG08_18255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG08_18265	COG0848	biopolymer transport protein
ITG08_18270	COG0811	peptide transport
ITG08_18275	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ITG08_18285	COG3721	Heme iron utilization protein
ITG08_18290	COG0748	coenzyme F420 binding
ITG08_18295	COG2096	Adenosyltransferase
ITG08_18300	COG0784	Response regulator, receiver
ITG08_18300	COG0835	chemotaxis
ITG08_18305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITG08_18310	COG0366	Alpha amylase catalytic
ITG08_18320	COG3314	Sporulation integral membrane protein YlbJ
ITG08_18345	COG0739	heme binding
ITG08_18350	COG5001	Diguanylate cyclase
ITG08_18355	COG0583	DNA-binding transcription factor activity
ITG08_18360	COG2814	Major facilitator Superfamily
ITG08_18375	COG0697	spore germination
ITG08_18395	COG3118	belongs to the thioredoxin family
ITG08_18400	COG4232	protein-disulfide reductase activity
ITG08_18415	COG0668	transmembrane transport
ITG08_18460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_18465	COG1538	Outer membrane efflux protein
ITG08_18485	COG4989	oxidoreductase activity
ITG08_18490	COG0513	Belongs to the DEAD box helicase family
ITG08_18505	COG2176	DNA-directed DNA polymerase activity
ITG08_18515	COG0513	Belongs to the DEAD box helicase family
ITG08_18520	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ITG08_18525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ITG08_18530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITG08_18535	COG0667	Aldo Keto reductase
ITG08_18545	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITG08_18565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_18580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITG08_18595	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ITG08_18600	COG0513	Belongs to the DEAD box helicase family
ITG08_18605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITG08_18620	COG0604	alcohol dehydrogenase
ITG08_18645	COG4772	TonB-dependent receptor
ITG08_18650	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ITG08_18655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG08_18660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG08_18665	COG1120	ATPase activity
ITG08_18670	COG0697	spore germination
ITG08_18680	COG0583	DNA-binding transcription factor activity
ITG08_18695	COG0366	Alpha amylase catalytic
ITG08_18700	COG0583	DNA-binding transcription factor activity
ITG08_18705	COG0534	Mate efflux family protein
ITG08_18730	COG0516	GMP reductase activity
ITG08_19010	COG3938	Belongs to the proline racemase family
ITG08_19015	COG2022	thiamine diphosphate biosynthetic process
ITG08_19015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG08_19025	COG2423	ornithine cyclodeaminase activity
ITG08_19035	COG3842	ATPase activity
ITG08_19045	COG1177	transmembrane transport
ITG08_19075	COG0697	spore germination
ITG08_19080	COG0351	phosphomethylpyrimidine kinase
ITG08_19085	COG1116	anion transmembrane transporter activity
ITG08_19090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITG08_19095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITG08_19100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ITG08_19105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ITG08_19110	COG0840	transmembrane signaling receptor activity
ITG08_19125	COG0583	DNA-binding transcription factor activity
ITG08_19140	COG1566	PFAM secretion protein HlyD family protein
ITG08_19150	COG0628	permease
ITG08_19175	COG4607	ABC-type enterochelin transport system periplasmic component
ITG08_19180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITG08_19185	COG4605	iron ion homeostasis
ITG08_19190	COG4604	ABC transporter, ATP-binding protein
ITG08_19195	COG3437	response regulator, receiver
ITG08_19200	COG2205	protein histidine kinase activity
ITG08_19200	COG0784	Response regulator, receiver
ITG08_19200	COG2198	Histidine kinase
ITG08_19200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITG08_19205	COG0583	DNA-binding transcription factor activity
ITG08_19210	COG2814	Major facilitator Superfamily
ITG08_19230	COG1522	sequence-specific DNA binding
ITG08_19235	COG0840	transmembrane signaling receptor activity
ITG08_19240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITG08_19255	COG5001	Diguanylate cyclase
ITG08_19255	COG4251	negative regulation of phosphorylation
ITG08_19255	COG3706	GGDEF domain
ITG08_19255	COG2203	Gaf domain
ITG08_19260	COG2897	thiosulfate sulfurtransferase activity
ITG08_19290	COG0302	gtp cyclohydrolase
ITG08_19300	COG4681	YaeQ
ITG08_19305	COG1278	Cold shock
ITG08_19310	COG2133	pyrroloquinoline quinone binding
ITG08_19320	COG1120	ATPase activity
ITG08_19350	COG1024	Enoyl-CoA hydratase
ITG08_19365	COG0446	pyridine nucleotide-disulphide oxidoreductase
ITG08_19365	COG1902	pentaerythritol trinitrate reductase activity
ITG08_19385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_19390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG08_19405	COG2273	Hydrolase Family 16
ITG08_19405	COG5297	Belongs to the glycosyl hydrolase family 6
ITG08_19425	COG2824	Alkylphosphonate utilization operon protein PhnA
ITG08_19450	COG0765	amino acid transport
ITG08_19460	COG0765	amino acid transport
ITG08_19465	COG1126	abc transporter atp-binding protein
ITG08_19470	COG1979	alcohol dehydrogenase
ITG08_19475	COG2207	Transcriptional regulator
ITG08_19495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG08_19515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG08_19525	COG2199	diguanylate cyclase activity
ITG08_19540	COG1686	Belongs to the peptidase S11 family
ITG08_19550	COG0564	pseudouridine synthase activity
ITG08_19560	COG2130	NADP-dependent
ITG08_19565	COG1309	transcriptional regulator
ITG08_19570	COG0545	Peptidyl-prolyl cis-trans isomerase
ITG08_19590	COG3604	Transcriptional regulator
ITG08_19595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG08_19595	COG1017	nitric oxide dioxygenase activity
ITG08_19600	COG1609	Transcriptional regulator
ITG08_19610	COG1175	transmembrane transport
ITG08_19615	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ITG08_19625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ITG08_19635	COG0038	chloride channel
ITG08_19640	COG0523	cobalamin synthesis protein
ITG08_19645	COG0513	Belongs to the DEAD box helicase family
ITG08_19680	COG0745	RESPONSE REGULATOR receiver
ITG08_19725	COG0183	Belongs to the thiolase family
ITG08_19735	COG3243	poly(R)-hydroxyalkanoic acid synthase
ITG08_19745	COG3005	denitrification pathway
ITG08_19755	COG0243	molybdopterin cofactor binding
ITG08_19765	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG08_19765	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ITG08_19770	COG3850	Histidine kinase
ITG08_19775	COG2197	response regulator
ITG08_19780	COG3069	C4-dicarboxylate transmembrane transporter activity
ITG08_19795	COG2267	carboxylic ester hydrolase activity
ITG08_19800	COG2067	long-chain fatty acid transport protein
ITG08_19805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_19810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITG08_19835	COG2188	Transcriptional regulator
ITG08_19840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_19840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_19840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_19845	COG0383	alpha-mannosidase activity
ITG08_19850	COG1929	Belongs to the glycerate kinase type-1 family
ITG08_19865	COG1214	PFAM Peptidase M22, glycoprotease
ITG08_19865	COG0456	acetyltransferase
ITG08_19870	COG2203	Gaf domain
ITG08_19870	COG2199	diguanylate cyclase activity
ITG08_19875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ITG08_19930	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ITG08_19935	COG0494	nUDIX hydrolase
ITG08_19945	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ITG08_19970	COG0840	transmembrane signaling receptor activity
ITG08_20020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG08_20030	COG2116	formate transmembrane transporter activity
ITG08_20035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITG08_20035	COG1648	precorrin-2 dehydrogenase activity
ITG08_20050	COG0745	RESPONSE REGULATOR receiver
ITG08_20055	COG2205	protein histidine kinase activity
ITG08_20060	COG1301	dicarboxylic acid transport
ITG08_20075	COG0811	peptide transport
ITG08_20080	COG0811	peptide transport
ITG08_20085	COG0848	biopolymer transport protein
ITG08_20130	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITG08_20135	COG1121	(ABC) transporter
ITG08_20140	COG1321	iron dependent repressor
ITG08_20140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITG08_20165	COG0534	Mate efflux family protein
ITG08_20195	COG0318	PFAM AMP-dependent synthetase and ligase
ITG08_20205	COG3118	belongs to the thioredoxin family
ITG08_20210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITG08_20240	COG1328	CTP reductase activity
ITG08_20245	COG0602	queuosine metabolic process
ITG08_20255	COG4067	protein conserved in archaea
ITG08_20255	COG0189	ligase activity
ITG08_20260	COG0488	(ABC) transporter
ITG08_20280	COG0725	ABC transporter, periplasmic molybdate-binding protein
ITG08_20285	COG4149	molybdate abc transporter
ITG08_20290	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ITG08_20300	COG5001	Diguanylate cyclase
ITG08_20300	COG2203	Gaf domain
ITG08_20300	COG4251	negative regulation of phosphorylation
ITG08_20300	COG3706	GGDEF domain
ITG08_20310	COG3706	GGDEF domain
ITG08_20325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ITG08_20330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ITG08_20445	COG3140	Belongs to the UPF0181 family
ITG08_20525	COG0023	Translation Initiation Factor
ITG08_20540	COG1181	Belongs to the D-alanine--D-alanine ligase family
ITG08_20545	COG3266	domain, Protein
ITG08_20550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG08_20550	COG1042	CoA-binding domain protein
ITG08_20550	COG0045	succinate-CoA ligase (ADP-forming) activity
ITG08_20555	COG0583	DNA-binding transcription factor activity
ITG08_20560	COG1629	transport
ITG08_20560	COG4771	TonB-dependent receptor
ITG08_20575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ITG08_20580	COG1984	allophanate hydrolase subunit 2
ITG08_20590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ITG08_20595	COG4181	ATPase activity
ITG08_20605	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITG08_20610	COG5001	Diguanylate cyclase
ITG08_20610	COG1716	ATPase activity
ITG08_20620	COG0768	penicillin binding
ITG08_20650	COG4533	DNA binding
ITG08_20660	COG2050	protein possibly involved in aromatic compounds catabolism
ITG08_20665	COG0501	Belongs to the peptidase M48B family
ITG08_20675	COG2067	long-chain fatty acid transport protein
ITG08_20680	COG2267	carboxylic ester hydrolase activity
ITG08_20695	COG0583	DNA-binding transcription factor activity
ITG08_20710	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ITG08_20720	COG2985	domain, Protein
ITG08_20730	COG1566	PFAM secretion protein HlyD family protein
ITG08_20745	COG2272	Belongs to the type-B carboxylesterase lipase family
ITG08_20750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITG08_20755	COG0729	surface antigen
ITG08_20760	COG0513	Belongs to the DEAD box helicase family
ITG08_20775	COG0861	Integral membrane protein TerC family
ITG08_20780	COG0737	Belongs to the 5'-nucleotidase family
ITG08_20785	COG3593	DNA synthesis involved in DNA repair
ITG08_20795	COG0583	DNA-binding transcription factor activity
ITG08_20800	COG2116	formate transmembrane transporter activity
ITG08_20805	COG2353	YceI-like domain
ITG08_20810	COG3038	cytochrome b561
ITG08_20825	COG2200	EAL domain
ITG08_20850	COG0513	Belongs to the DEAD box helicase family
ITG08_20855	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ITG08_20860	COG0814	amino acid
ITG08_20870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG08_20875	COG3437	response regulator, receiver
ITG08_20875	COG0784	Response regulator, receiver
ITG08_20890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG08_20895	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ITG08_20900	COG3706	GGDEF domain
ITG08_20905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITG08_20945	COG0509	glycine decarboxylation via glycine cleavage system
ITG08_20985	COG0534	Mate efflux family protein
ITG08_21010	COG1280	lysine exporter protein (LysE YggA)
ITG08_21045	COG2807	transmembrane transport
ITG08_21055	COG1881	PFAM PEBP family protein
ITG08_21090	COG0840	transmembrane signaling receptor activity
ITG08_21125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITG08_21130	COG2205	protein histidine kinase activity
ITG08_21130	COG0784	Response regulator, receiver
ITG08_21135	COG1538	Outer membrane efflux protein
ITG08_21140	COG1132	(ABC) transporter
ITG08_21180	COG0840	transmembrane signaling receptor activity
ITG08_21185	COG0405	Gamma-glutamyltransferase
ITG08_21195	COG0641	radical SAM
ITG08_21210	COG1597	lipid kinase activity
ITG08_21215	COG0583	DNA-binding transcription factor activity
ITG08_21245	COG0714	Associated with various cellular activities
ITG08_21255	COG3119	arylsulfatase activity
ITG08_21260	COG3119	arylsulfatase activity
ITG08_21265	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ITG08_21280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ITG08_21295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ITG08_21320	COG0384	phenazine biosynthesis protein PhzF
ITG08_21330	COG3300	MHYT domain
ITG08_21330	COG5001	Diguanylate cyclase
ITG08_21345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITG08_21345	COG3153	acetyltransferase
ITG08_21350	COG2199	diguanylate cyclase activity
ITG08_21360	COG3278	Belongs to the heme-copper respiratory oxidase family
ITG08_21400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITG08_21410	COG1012	belongs to the aldehyde dehydrogenase family
ITG08_21420	COG0583	DNA-binding transcription factor activity
ITG08_21430	COG0356	it plays a direct role in the translocation of protons across the membrane
ITG08_21445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITG08_21455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITG08_21465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITG08_21475	COG4172	Belongs to the ABC transporter superfamily
ITG08_21480	COG4239	(ABC) transporter, permease
ITG08_21485	COG4174	ABC transporter (Permease)
ITG08_21490	COG4166	transmembrane transport
ITG08_21505	COG1869	D-ribose catabolic process
ITG08_21510	COG1129	ABC transporter
ITG08_21515	COG1172	Belongs to the binding-protein-dependent transport system permease family
ITG08_21520	COG1879	ABC-type sugar transport system periplasmic component
ITG08_21525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITG08_21530	COG1609	Transcriptional regulator
ITG08_21550	COG0784	Response regulator, receiver
ITG08_21550	COG2205	protein histidine kinase activity
ITG08_21590	COG3547	Transposase (IS116 IS110 IS902 family)
ITG08_21620	COG0243	molybdopterin cofactor binding
ITG08_21625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITG08_21635	COG2223	nitrite transmembrane transporter activity
ITG08_21640	COG2815	serine threonine protein kinase
ITG08_21640	COG0515	serine threonine protein kinase
ITG08_21645	COG1609	Transcriptional regulator
ITG08_21650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_21650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_21655	COG1105	Belongs to the carbohydrate kinase PfkB family
ITG08_21660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_21660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITG08_21660	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ITG08_21670	COG0625	glutathione transferase activity
ITG08_21725	COG1879	ABC-type sugar transport system periplasmic component
ITG08_21730	COG1803	Methylglyoxal synthase
ITG08_21740	COG0210	DNA helicase
ITG08_21745	COG1289	transmembrane transporter activity
ITG08_21765	COG0583	DNA-binding transcription factor activity
ITG08_21770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ITG08_21775	COG1328	CTP reductase activity
ITG08_21780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITG08_21805	COG1011	Hydrolase
ITG08_21815	COG1454	alcohol dehydrogenase
ITG08_21835	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITG08_21845	COG1063	alcohol dehydrogenase
ITG08_21850	COG0156	8-amino-7-oxononanoate synthase activity
ITG08_21860	COG0346	lactoylglutathione lyase activity
ITG08_21880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITG08_21885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG08_21900	COG0393	Putative heavy-metal-binding
ITG08_21905	COG0739	heme binding
ITG08_21930	COG1132	(ABC) transporter
ITG08_21935	COG1132	(ABC) transporter
ITG08_21940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITG08_21955	COG1760	l-serine dehydratase
ITG08_21960	COG3104	oligopeptide transport
ITG08_21965	COG2375	cellular response to nickel ion
ITG08_21970	COG1609	Transcriptional regulator
ITG08_21975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITG08_21980	COG3265	gluconokinase activity
ITG08_21985	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ITG08_21995	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ITG08_22015	COG3842	ATPase activity
ITG08_22020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITG08_22025	COG1840	ABC-type Fe3 transport system, periplasmic component
ITG08_22035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITG08_22045	COG2885	chlorophyll binding
ITG08_22050	COG1765	OsmC-like protein
ITG08_22055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG08_22055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ITG08_22060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITG08_22065	COG0569	domain protein
ITG08_22070	COG0668	transmembrane transport
ITG08_22080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG08_22085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ITG08_22100	COG3530	Putative quorum-sensing-regulated virulence factor
ITG08_22115	COG0109	protoheme IX farnesyltransferase activity
ITG08_22120	COG1612	heme a metabolic process
ITG08_22140	COG1845	cytochrome c oxidase, subunit III
ITG08_22150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITG08_22155	COG1565	acr, cog1565
ITG08_22155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITG08_22160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITG08_22165	COG1280	lysine exporter protein (LysE YggA)
ITG08_22170	COG0179	Fumarylacetoacetate (FAA) hydrolase
ITG08_22180	COG0443	Heat shock 70 kDa protein
ITG08_22210	COG2827	Endonuclease containing a URI domain
ITG08_22215	COG3132	Protein of unknown function, DUF480
ITG08_22225	COG2926	Belongs to the UPF0265 family
ITG08_22250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITG08_22255	COG1151	hydroxylamine reductase activity
ITG08_22270	COG1280	lysine exporter protein (LysE YggA)
ITG08_22285	COG0531	amino acid
ITG08_22300	COG4413	Urea transporter
ITG08_22320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITG08_22325	COG0402	S-adenosylhomocysteine deaminase activity
ITG08_22330	COG1278	Cold shock
ITG08_22335	COG3706	GGDEF domain
ITG08_22350	COG0513	Belongs to the DEAD box helicase family
ITG08_22365	COG4106	trans-aconitate 2-methyltransferase activity
ITG08_22370	COG0642	Histidine kinase
ITG08_22375	COG0745	RESPONSE REGULATOR receiver
ITG08_22400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITG08_22420	COG3037	sugar-specific permease SgaT UlaA
ITG08_22425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITG08_22430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ITG08_22435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITG08_22440	COG2205	protein histidine kinase activity
ITG08_22445	COG0745	RESPONSE REGULATOR receiver
ITG08_22455	COG5001	Diguanylate cyclase
ITG08_22460	COG5001	Diguanylate cyclase
ITG08_22470	COG1131	(ABC) transporter
ITG08_22490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG08_22490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITG08_22500	COG0564	pseudouridine synthase activity
ITG08_22510	COG2814	Major facilitator Superfamily
ITG08_22520	COG1335	isochorismatase
ITG08_22555	COG4533	DNA binding
ITG08_22560	COG0189	ligase activity
ITG08_22565	COG0189	ligase activity
ITG08_22565	COG4067	protein conserved in archaea
ITG08_22590	COG0395	ABC-type sugar transport system, permease component
ITG08_22595	COG3842	ATPase activity
ITG08_22600	COG0584	glycerophosphoryl diester phosphodiesterase
ITG08_22620	COG0673	inositol 2-dehydrogenase activity
ITG08_22630	COG2999	glutathione oxidoreductase activity
ITG08_22635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ITG08_22655	COG4977	sequence-specific DNA binding
ITG08_22715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITG08_22730	COG1192	Involved in chromosome partitioning
ITG08_22820	COG0270	DNA (cytosine-5-)-methyltransferase activity
ITG08_22840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair