locus-tag	class	description
AL537_00015	COG1677	Flagellar hook-basal body complex protein FliE
AL537_00020	COG2204	response regulator
AL537_00025	COG4191	Histidine kinase
AL537_00035	COG1516	flagellar protein fliS
AL537_00045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL537_00050	COG1334	flagellar protein FlaG
AL537_00055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_00060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_00070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_00075	COG2837	iron assimilation
AL537_00100	COG1393	Belongs to the ArsC family
AL537_00105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL537_00125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL537_00135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL537_00150	COG4783	chaperone-mediated protein folding
AL537_00155	COG1393	Belongs to the ArsC family
AL537_00175	COG2233	PERMEase
AL537_00180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL537_00185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL537_00190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL537_00195	COG0121	glutamine amidotransferase
AL537_00200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL537_00205	COG1960	acyl-CoA dehydrogenase activity
AL537_00235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL537_00240	COG0328	RNA-DNA hybrid ribonuclease activity
AL537_00245	COG2226	methyltransferase
AL537_00250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL537_00255	COG0741	lytic transglycosylase activity
AL537_00255	COG1388	LysM domain
AL537_00265	COG3021	interspecies interaction between organisms
AL537_00270	COG0347	Belongs to the P(II) protein family
AL537_00285	COG0825	malonyl-CoA metabolic process
AL537_00290	COG0587	DNA-directed DNA polymerase activity
AL537_00300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_00305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_00315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_00320	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL537_00330	COG0750	zinc metalloprotease
AL537_00335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL537_00340	COG0575	Belongs to the CDS family
AL537_00345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL537_00350	COG0233	cytoplasmic translational termination
AL537_00355	COG0528	UMP kinase activity
AL537_00360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL537_00365	COG0052	Belongs to the universal ribosomal protein uS2 family
AL537_00370	COG0024	Methionine aminopeptidase
AL537_00375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL537_00385	COG0564	pseudouridine synthase activity
AL537_00420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL537_00425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL537_00450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL537_00460	COG0254	rRNA binding
AL537_00465	COG1720	tRNA m6t6A37 methyltransferase activity
AL537_00470	COG0442	prolyl-tRNA aminoacylation
AL537_00490	COG0733	neurotransmitter:sodium symporter activity
AL537_00505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_00510	COG0514	ATP-dependent DNA helicase (RecQ)
AL537_00515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL537_00530	COG1477	protein flavinylation
AL537_00535	COG2871	sodium ion transport
AL537_00540	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_00545	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_00550	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_00555	COG1805	sodium ion transport
AL537_00560	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_00570	COG0271	Belongs to the BolA IbaG family
AL537_00575	COG2813	Specifically methylates the guanine in position
AL537_00580	COG3056	Lipoprotein
AL537_00600	COG1595	DNA-templated transcription, initiation
AL537_00620	COG3248	Nucleoside-binding outer membrane protein
AL537_00625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL537_00630	COG0693	protein deglycase activity
AL537_00635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL537_00640	COG3706	GGDEF domain
AL537_00645	COG2166	iron-sulfur cluster assembly
AL537_00650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL537_00655	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL537_00670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL537_00670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL537_00680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL537_00685	COG1074	ATP-dependent DNA helicase activity
AL537_00695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL537_00715	COG3141	response to X-ray
AL537_00720	COG2171	N-acyltransferase activity
AL537_00725	COG0584	glycerophosphoryl diester phosphodiesterase
AL537_00730	COG2271	Major facilitator Superfamily
AL537_00740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL537_00745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL537_00750	COG1349	DNA-binding transcription factor activity
AL537_00755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL537_00775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_00780	COG1609	Transcriptional regulator
AL537_00785	COG2211	Major facilitator Superfamily
AL537_00800	COG2017	converts alpha-aldose to the beta-anomer
AL537_00805	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL537_00815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL537_00825	COG1609	Transcriptional regulator
AL537_00830	COG3250	beta-galactosidase activity
AL537_00835	COG2731	YhcH YjgK YiaL family protein
AL537_00840	COG0531	amino acid
AL537_00845	COG0583	DNA-binding transcription factor activity
AL537_00905	COG4964	Belongs to the GSP D family
AL537_00930	COG2169	Transcriptional regulator
AL537_00935	COG1022	Amp-dependent synthetase and ligase
AL537_00945	COG0583	DNA-binding transcription factor activity
AL537_00950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL537_00955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL537_00965	COG0560	Phosphoserine phosphatase
AL537_00975	COG0813	purine-nucleoside phosphorylase activity
AL537_00980	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL537_00985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL537_01000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL537_01005	COG0084	hydrolase, TatD family'
AL537_01015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL537_01035	COG3153	acetyltransferase
AL537_01065	COG0534	Mate efflux family protein
AL537_01080	COG1185	polyribonucleotide nucleotidyltransferase activity
AL537_01085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL537_01090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL537_01095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL537_01100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL537_01105	COG0195	Participates in both transcription termination and antitermination
AL537_01110	COG0779	Required for maturation of 30S ribosomal subunits
AL537_01125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL537_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL537_01140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL537_01145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL537_01150	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL537_01155	COG1534	Rna-binding protein
AL537_01160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_01165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_01170	COG2027	D-alanyl-D-alanine carboxypeptidase
AL537_01180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL537_01185	COG0739	heme binding
AL537_01205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL537_01210	COG0628	permease
AL537_01215	COG2813	Specifically methylates the guanine in position
AL537_01225	COG0747	negative chemotaxis
AL537_01240	COG0444	Belongs to the ABC transporter superfamily
AL537_01245	COG4608	Belongs to the ABC transporter superfamily
AL537_01255	COG2971	BadF BadG BcrA BcrD
AL537_01270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL537_01275	COG3842	ATPase activity
AL537_01285	COG1840	ABC-type Fe3 transport system, periplasmic component
AL537_01290	COG0004	ammonium transporteR
AL537_01295	COG0347	Belongs to the P(II) protein family
AL537_01300	COG3112	Uncharacterised protein family (UPF0231)
AL537_01305	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL537_01310	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL537_01315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL537_01320	COG1643	Atp-dependent helicase
AL537_01325	COG1489	DNA binding
AL537_01330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL537_01335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL537_01345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL537_01350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL537_01355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL537_01360	COG1560	Kdo2-lipid A biosynthetic process
AL537_01370	COG0842	Transport permease protein
AL537_01375	COG1131	(ABC) transporter
AL537_01380	COG0659	secondary active sulfate transmembrane transporter activity
AL537_01385	COG0288	reversible hydration of carbon dioxide
AL537_01400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_01405	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL537_01410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL537_01415	COG2186	Transcriptional regulator
AL537_01425	COG0157	Belongs to the NadC ModD family
AL537_01435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL537_01440	COG1459	type II secretion system
AL537_01450	COG0237	dephospho-CoA kinase activity
AL537_01455	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL537_01460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL537_01475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL537_01480	COG0228	four-way junction DNA binding
AL537_01485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL537_01490	COG4137	Cytochrome C assembly protein
AL537_01495	COG4536	flavin adenine dinucleotide binding
AL537_01500	COG1854	S-ribosylhomocysteine lyase activity
AL537_01515	COG0612	Peptidase, M16
AL537_01520	COG1238	metal cluster binding
AL537_01530	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL537_01535	COG5016	pyruvate
AL537_01535	COG0511	ligase activity, forming carbon-carbon bonds
AL537_01605	COG0527	aspartate kinase activity
AL537_01610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL537_01615	COG2137	regulation of response to DNA damage stimulus
AL537_01620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL537_01625	COG1546	Belongs to the CinA family
AL537_01630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL537_01635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL537_01645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL537_01650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL537_01665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL537_01670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL537_01675	COG0148	phosphopyruvate hydratase activity
AL537_01680	COG0504	CTP synthase activity
AL537_01685	COG3956	TIGRFAM MazG family protein
AL537_01690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL537_01700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL537_01715	COG0736	holo-[acyl-carrier-protein] synthase activity
AL537_01720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL537_01725	COG1381	Involved in DNA repair and RecF pathway recombination
AL537_01730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL537_01740	COG0681	Belongs to the peptidase S26 family
AL537_01745	COG0481	GTPase activity
AL537_01750	COG3086	response to oxidative stress
AL537_01765	COG1595	DNA-templated transcription, initiation
AL537_01775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL537_01785	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL537_01790	COG0354	folic acid binding
AL537_01805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL537_01810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL537_01815	COG3079	Belongs to the UPF0149 family
AL537_01825	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL537_01835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL537_01840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL537_01845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL537_01855	COG0583	DNA-binding transcription factor activity
AL537_01870	COG0668	transmembrane transport
AL537_01875	COG0191	fructose-bisphosphate aldolase activity
AL537_01880	COG0126	phosphoglycerate kinase activity
AL537_01885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL537_01890	COG4771	TonB-dependent receptor
AL537_01895	COG0583	DNA-binding transcription factor activity
AL537_01900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL537_01910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL537_01925	COG2356	endonuclease I
AL537_01930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL537_01935	COG0189	ligase activity
AL537_01940	COG1678	Uncharacterized ACR, COG1678
AL537_01945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL537_01960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL537_01965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL537_01970	COG0762	integral membrane protein
AL537_01975	COG1872	DUF167
AL537_01985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL537_01990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL537_01995	COG2066	Belongs to the glutaminase family
AL537_02005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL537_02015	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL537_02090	COG1012	belongs to the aldehyde dehydrogenase family
AL537_02140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL537_02150	COG3394	polysaccharide catabolic process
AL537_02155	COG1486	melibiose metabolic process
AL537_02160	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL537_02165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL537_02175	COG0726	polysaccharide deacetylase
AL537_02185	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_02190	COG4325	translation initiation factor activity
AL537_02200	COG0795	lipopolysaccharide-transporting ATPase activity
AL537_02205	COG0795	lipopolysaccharide-transporting ATPase activity
AL537_02215	COG2927	DNA polymerase III (CHI subunit)
AL537_02220	COG0525	valine-tRNA ligase activity
AL537_02260	COG0540	Belongs to the ATCase OTCase family
AL537_02265	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL537_02270	COG0251	oxidation-reduction process
AL537_02275	COG0204	Acyl-transferase
AL537_02285	COG5007	Belongs to the BolA IbaG family
AL537_02295	COG2854	intermembrane phospholipid transfer
AL537_02300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL537_02305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL537_02310	COG1127	ABC transporter
AL537_02330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL537_02335	COG1137	ATPase activity
AL537_02345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL537_02350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_02355	COG1660	Displays ATPase and GTPase activities
AL537_02360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_02365	COG2239	Acts as a magnesium transporter
AL537_02370	COG0312	modulator of DNA gyrase
AL537_02375	COG3028	Belongs to the UPF0307 family
AL537_02380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL537_02385	COG0564	pseudouridine synthase activity
AL537_02395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL537_02400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL537_02405	COG0312	modulator of DNA gyrase
AL537_02410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL537_02415	COG3164	Protein of unknown function
AL537_02420	COG1530	ribonuclease E activity
AL537_02425	COG0424	maF-like protein
AL537_02430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL537_02435	COG1792	Involved in formation and maintenance of cell shape
AL537_02440	COG1077	Cell shape determining protein MreB Mrl
AL537_02485	COG1459	type II secretion system
AL537_02490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL537_02500	COG3267	Type II secretory pathway component ExeA
AL537_02500	COG3409	Peptidoglycan-binding domain 1 protein
AL537_02505	COG1450	Type ii and iii secretion system protein
AL537_02525	COG2200	EAL domain
AL537_02525	COG2199	diguanylate cyclase activity
AL537_02530	COG0629	single-stranded DNA binding
AL537_02545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL537_02555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL537_02565	COG0527	aspartate kinase activity
AL537_02570	COG0646	methionine synthase
AL537_02570	COG1410	methionine synthase
AL537_02635	COG0175	sulfate reduction
AL537_02640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_02645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL537_02665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL537_02670	COG0735	belongs to the Fur family
AL537_02680	COG0166	Belongs to the GPI family
AL537_02685	COG0432	Pfam Uncharacterised protein family UPF0047
AL537_02690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL537_02695	COG0305	Participates in initiation and elongation during chromosome replication
AL537_02715	COG2965	DNA replication, synthesis of RNA primer
AL537_02720	COG0360	Binds together with S18 to 16S ribosomal RNA
AL537_02725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL537_02730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL537_02740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL537_02745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL537_02775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL537_02790	COG0678	peroxiredoxin activity
AL537_02790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL537_02795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_02810	COG0165	Argininosuccinate lyase
AL537_02810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL537_02815	COG0137	argininosuccinate synthase activity
AL537_02825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL537_02835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL537_02845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL537_02850	COG0460	homoserine dehydrogenase
AL537_02850	COG0527	aspartate kinase activity
AL537_02855	COG0626	cystathionine gamma-synthase activity
AL537_02865	COG0281	malic enzyme
AL537_02875	COG2906	2 iron, 2 sulfur cluster binding
AL537_02880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL537_02885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL537_02900	COG2168	tRNA wobble position uridine thiolation
AL537_02905	COG2923	Belongs to the DsrF TusC family
AL537_02910	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL537_02915	COG2964	Protein conserved in bacteria
AL537_02920	COG0545	Peptidyl-prolyl cis-trans isomerase
AL537_02935	COG1446	asparaginase
AL537_02940	COG1047	Peptidyl-prolyl cis-trans
AL537_02955	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL537_02960	COG0488	(ABC) transporter
AL537_02970	COG0429	hydrolase of the alpha beta-hydrolase fold
AL537_02975	COG3089	Belongs to the UPF0270 family
AL537_02980	COG3954	Phosphoribulokinase
AL537_02985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_03005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL537_03025	COG0180	Tryptophanyl-tRNA synthetase
AL537_03030	COG0546	phosphoglycolate phosphatase activity
AL537_03035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL537_03040	COG0557	exoribonuclease II activity
AL537_03045	COG1959	2 iron, 2 sulfur cluster binding
AL537_03050	COG1017	nitric oxide dioxygenase activity
AL537_03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL537_03055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL537_03065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL537_03070	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL537_03075	COG0330	HflC and HflK could
AL537_03080	COG0330	HflC and HflK could
AL537_03085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL537_03095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL537_03100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL537_03110	COG0802	atpase or kinase
AL537_03120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL537_03185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL537_03190	COG1162	GTPase activity
AL537_03195	COG0688	phosphatidylethanolamine metabolic process
AL537_03200	COG3273	potassium ion transport
AL537_03200	COG0471	metal ion transport
AL537_03210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL537_03215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_03220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL537_03225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL537_03230	COG1045	serine acetyltransferase
AL537_03235	COG4942	peptidase
AL537_03255	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL537_03260	COG1053	succinate dehydrogenase
AL537_03265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL537_03270	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL537_03290	COG1509	lysine 2,3-aminomutase activity
AL537_03295	COG1285	pathogenesis
AL537_03305	COG0459	protein refolding
AL537_03310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL537_03315	COG0534	Mate efflux family protein
AL537_03320	COG0205	6-phosphofructokinase activity
AL537_03325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL537_03330	COG3678	ATP-independent chaperone mediated protein folding
AL537_03335	COG0745	RESPONSE REGULATOR receiver
AL537_03340	COG2205	protein histidine kinase activity
AL537_03350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL537_03360	COG1027	Aspartate ammonia-lyase
AL537_03365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL537_03370	COG4232	protein-disulfide reductase activity
AL537_03380	COG3263	regulation of cellular component size
AL537_03390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL537_03415	COG2814	Major facilitator Superfamily
AL537_03430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL537_03435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL537_03440	COG0511	ligase activity, forming carbon-carbon bonds
AL537_03445	COG0439	Biotin carboxylase
AL537_03455	COG2264	protein methyltransferase activity
AL537_03460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL537_03465	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL537_03475	COG0488	(ABC) transporter
AL537_03530	COG1982	Orn Lys Arg decarboxylase major
AL537_03535	COG0531	amino acid
AL537_03545	COG3710	Transcriptional regulator
AL537_03550	COG0789	Transcriptional regulator
AL537_03560	COG0138	bifunctional purine biosynthesis protein purh
AL537_03570	COG0151	Belongs to the GarS family
AL537_03585	COG1253	flavin adenine dinucleotide binding
AL537_03590	COG3068	Protein conserved in bacteria
AL537_03600	COG1573	uracil-dna glycosylase
AL537_03605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL537_03610	COG2816	NAD+ diphosphatase activity
AL537_03615	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL537_03620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL537_03625	COG0085	RNA polymerase activity
AL537_03630	COG0222	ribosome binding
AL537_03635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL537_03650	COG0250	Participates in transcription elongation, termination and antitermination
AL537_03655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL537_03665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL537_03700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL537_03700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL537_03705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL537_03715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL537_03795	COG4206	TonB-dependent receptor
AL537_03815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_03820	COG0534	Mate efflux family protein
AL537_03825	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL537_03835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL537_03845	COG2937	Belongs to the GPAT DAPAT family
AL537_03850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL537_03855	COG3161	chorismate lyase activity
AL537_03860	COG1580	Controls the rotational direction of flagella during chemotaxis
AL537_03865	COG0705	Rhomboid family
AL537_03870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_03885	COG2177	Part of the ABC transporter FtsEX involved in
AL537_03890	COG2884	Cell division ATP-binding protein ftsE
AL537_03895	COG0552	protein localization to endoplasmic reticulum
AL537_03900	COG0742	ribosomal rna small subunit methyltransferase
AL537_03910	COG2095	MarC family integral membrane protein
AL537_03960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL537_03965	COG0640	Transcriptional regulator
AL537_03970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL537_03975	COG1280	lysine exporter protein (LysE YggA)
AL537_03980	COG2267	carboxylic ester hydrolase activity
AL537_03985	COG0561	phosphatase activity
AL537_04005	COG3287	FIST C domain
AL537_04005	COG2200	EAL domain
AL537_04005	COG2199	diguanylate cyclase activity
AL537_04010	COG1011	Hydrolase
AL537_04015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL537_04025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL537_04030	COG0019	diaminopimelate decarboxylase activity
AL537_04040	COG1965	Belongs to the frataxin family
AL537_04045	COG3072	Adenylate cyclase
AL537_04050	COG0181	hydroxymethylbilane synthase activity
AL537_04055	COG1587	Uroporphyrinogen-III synthase
AL537_04060	COG2959	enzyme of heme biosynthesis
AL537_04065	COG3071	HemY protein
AL537_04115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL537_04130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL537_04135	COG3118	belongs to the thioredoxin family
AL537_04140	COG0513	Belongs to the DEAD box helicase family
AL537_04145	COG0248	Ppx GppA phosphatase
AL537_04150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL537_04160	COG0514	ATP-dependent DNA helicase (RecQ)
AL537_04165	COG2962	Rard protein
AL537_04175	COG1280	lysine exporter protein (LysE YggA)
AL537_04180	COG0405	Gamma-glutamyltransferase
AL537_04185	COG0210	DNA helicase
AL537_04195	COG3220	belongs to the UPF0276 family
AL537_04225	COG0006	proline dipeptidase activity
AL537_04225	COG0006	proline dipeptidase activity
AL537_04245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL537_04260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL537_04320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL537_04330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL537_04335	COG0408	coproporphyrinogen oxidase activity
AL537_04340	COG0009	L-threonylcarbamoyladenylate synthase
AL537_04345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL537_04350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL537_04355	COG0551	DNA topoisomerase type I activity
AL537_04360	COG2922	Belongs to the Smg family
AL537_04365	COG0758	DNA mediated transformation
AL537_04375	COG0242	peptide deformylase activity
AL537_04380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL537_04385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL537_04385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL537_04390	COG0569	domain protein
AL537_04395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_04405	COG1272	protein, Hemolysin III
AL537_04410	COG4326	sporulation control protein
AL537_04420	COG3084	Protein conserved in bacteria
AL537_04430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL537_04435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL537_04440	COG0204	Acyl-transferase
AL537_04450	COG0606	chelatase, subunit chli
AL537_04460	COG3978	acetolactate synthase activity
AL537_04465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL537_04470	COG0129	dihydroxy-acid dehydratase activity
AL537_04480	COG0583	DNA-binding transcription factor activity
AL537_04485	COG2814	Major facilitator Superfamily
AL537_04495	COG0765	amino acid transport
AL537_04505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL537_04510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL537_04515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL537_04520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL537_04525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL537_04530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL537_04540	COG0356	it plays a direct role in the translocation of protons across the membrane
AL537_04545	COG3312	ion transport
AL537_04550	COG1475	DNA binding
AL537_04555	COG1192	Involved in chromosome partitioning
AL537_04560	COG0357	Ribosomal RNA small subunit methyltransferase G
AL537_04565	COG0445	tRNA wobble uridine modification
AL537_04570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL537_04580	COG0706	membrane insertase activity
AL537_04585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL537_04590	COG0594	ribonuclease P activity
AL537_04600	COG1126	abc transporter atp-binding protein
AL537_04620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL537_04625	COG0592	DNA-directed DNA polymerase activity
AL537_04635	COG0187	DNA topoisomerase II activity
AL537_04650	COG0071	Belongs to the small heat shock protein (HSP20) family
AL537_04655	COG3977	Valine--pyruvate aminotransferase
AL537_04660	COG0366	Alpha amylase catalytic
AL537_04665	COG0751	glycine-tRNA ligase activity
AL537_04675	COG2119	membrane
AL537_04685	COG0425	Belongs to the sulfur carrier protein TusA family
AL537_04700	COG0604	alcohol dehydrogenase
AL537_04705	COG0183	Belongs to the thiolase family
AL537_04715	COG1739	Uncharacterized protein family UPF0029
AL537_04720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_04765	COG0583	DNA-binding transcription factor activity
AL537_04770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL537_04775	COG2960	long-chain fatty acid transporting porin activity
AL537_04780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_04785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_04840	COG4172	Belongs to the ABC transporter superfamily
AL537_04845	COG4166	transmembrane transport
AL537_04855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_04895	COG1609	Transcriptional regulator
AL537_04900	COG0583	DNA-binding transcription factor activity
AL537_04915	COG0129	dihydroxy-acid dehydratase activity
AL537_04920	COG3265	gluconokinase activity
AL537_04925	COG2610	gluconate transmembrane transporter activity
AL537_04930	COG0800	Aldolase
AL537_04935	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL537_04940	COG0583	DNA-binding transcription factor activity
AL537_04945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_04950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL537_04960	COG1522	sequence-specific DNA binding
AL537_04965	COG5001	Diguanylate cyclase
AL537_04965	COG5002	protein histidine kinase activity
AL537_04970	COG0742	ribosomal rna small subunit methyltransferase
AL537_04980	COG0697	spore germination
AL537_04985	COG0589	response to stress
AL537_04990	COG1528	Iron-storage protein
AL537_05000	COG2081	HI0933 family
AL537_05030	COG1597	lipid kinase activity
AL537_05060	COG0628	permease
AL537_05075	COG1322	Protein conserved in bacteria
AL537_05080	COG2226	methyltransferase
AL537_05085	COG3165	ubiquinone biosynthetic process from chorismate
AL537_05090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL537_05105	COG0805	protein transport
AL537_05115	COG0084	hydrolase, TatD family'
AL537_05130	COG0456	acetyltransferase
AL537_05140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_05140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_05145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL537_05175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL537_05180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL537_05190	COG2204	response regulator
AL537_05195	COG3852	Histidine kinase
AL537_05205	COG0174	glutamine synthetase
AL537_05230	COG1295	ribonuclease BN
AL537_05235	COG1490	D-aminoacyl-tRNA deacylase activity
AL537_05240	COG0456	acetyltransferase
AL537_05250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL537_05255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL537_05260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL537_05265	COG3031	protein transport across the cell outer membrane
AL537_05275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL537_05280	COG1459	type II secretion system
AL537_05285	COG2165	general secretion pathway protein
AL537_05290	COG2165	general secretion pathway protein
AL537_05295	COG2165	general secretion pathway protein
AL537_05300	COG4795	General secretion pathway protein
AL537_05305	COG3156	type II secretion system protein K
AL537_05310	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL537_05315	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL537_05325	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL537_05330	COG0494	nUDIX hydrolase
AL537_05335	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL537_05335	COG0316	Belongs to the HesB IscA family
AL537_05340	COG1040	competence protein
AL537_05345	COG0596	Alpha beta hydrolase
AL537_05355	COG2183	response to ionizing radiation
AL537_05365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_05375	COG0745	RESPONSE REGULATOR receiver
AL537_05380	COG2205	protein histidine kinase activity
AL537_05385	COG2233	PERMEase
AL537_05390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL537_05395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL537_05400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL537_05405	COG1758	RNA polymerase activity
AL537_05410	COG0194	GDP metabolic process
AL537_05425	COG0848	biopolymer transport protein
AL537_05430	COG0811	peptide transport
AL537_05455	COG4174	ABC transporter (Permease)
AL537_05460	COG4239	(ABC) transporter, permease
AL537_05465	COG0747	negative chemotaxis
AL537_05470	COG0444	Belongs to the ABC transporter superfamily
AL537_05475	COG4608	Belongs to the ABC transporter superfamily
AL537_05485	COG1561	YicC-like family, N-terminal region
AL537_05495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL537_05505	COG1560	Kdo2-lipid A biosynthetic process
AL537_05510	COG1309	transcriptional regulator
AL537_05515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL537_05525	COG2003	Belongs to the UPF0758 family
AL537_05555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL537_05570	COG0463	Glycosyl transferase, family 2
AL537_05575	COG0859	PFAM glycosyl transferase family 9
AL537_05580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL537_05585	COG3642	lipopolysaccharide core region biosynthetic process
AL537_05590	COG1086	Polysaccharide biosynthesis protein
AL537_05595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL537_05600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL537_05605	COG2089	acid synthase
AL537_05620	COG1083	cytidylyl-transferase
AL537_05635	COG1519	Transferase
AL537_05640	COG0859	PFAM glycosyl transferase family 9
AL537_05645	COG1560	Kdo2-lipid A biosynthetic process
AL537_05655	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_05690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL537_05695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL537_05705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AL537_05725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL537_05760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL537_05765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL537_05770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL537_05775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL537_05785	COG0110	maltose O-acetyltransferase activity
AL537_05805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL537_05815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL537_05835	COG0149	triose-phosphate isomerase activity
AL537_05865	COG1494	fructose-1,6-bisphosphatase
AL537_05880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL537_05885	COG1575	Belongs to the MenA family. Type 1 subfamily
AL537_05890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL537_05895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL537_05905	COG1609	Transcriptional regulator
AL537_05910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL537_05920	COG0254	rRNA binding
AL537_05930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL537_05935	COG0088	Forms part of the polypeptide exit tunnel
AL537_05945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL537_05950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL537_05955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL537_05960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL537_05970	COG0255	Belongs to the universal ribosomal protein uL29 family
AL537_05975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL537_05985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL537_05990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL537_05995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL537_06000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL537_06005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL537_06020	COG1841	ribosomal large subunit assembly
AL537_06030	COG0201	protein transport
AL537_06040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL537_06045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL537_06055	COG0202	RNA polymerase activity
AL537_06060	COG0203	ribosomal protein L17
AL537_06070	COG0545	Peptidyl-prolyl cis-trans isomerase
AL537_06080	COG2153	protein acetylation
AL537_06085	COG0513	Belongs to the DEAD box helicase family
AL537_06100	COG1648	precorrin-2 dehydrogenase activity
AL537_06100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL537_06105	COG0175	sulfate reduction
AL537_06110	COG2895	sulfate adenylyltransferase (ATP) activity
AL537_06115	COG3273	potassium ion transport
AL537_06115	COG0471	metal ion transport
AL537_06120	COG0529	Catalyzes the synthesis of activated sulfate
AL537_06140	COG4181	ATPase activity
AL537_06155	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL537_06165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_06170	COG0729	surface antigen
AL537_06175	COG2911	Protein conserved in bacteria
AL537_06180	COG2105	PFAM AIG2 family protein
AL537_06190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL537_06195	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL537_06205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL537_06210	COG0163	prenyltransferase activity
AL537_06215	COG4143	(ABC) transporter
AL537_06220	COG1178	ABC-type Fe3 transport system permease component
AL537_06225	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL537_06230	COG0583	DNA-binding transcription factor activity
AL537_06235	COG1902	pentaerythritol trinitrate reductase activity
AL537_06280	COG0142	geranyltranstransferase activity
AL537_06285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL537_06295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL537_06300	COG2966	Psort location CytoplasmicMembrane, score
AL537_06315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL537_06320	COG2967	ApaG domain
AL537_06325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL537_06330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL537_06335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL537_06340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL537_06345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL537_06365	COG0473	3-isopropylmalate dehydrogenase activity
AL537_06370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL537_06395	COG0583	DNA-binding transcription factor activity
AL537_06400	COG1022	Amp-dependent synthetase and ligase
AL537_06405	COG0028	Belongs to the TPP enzyme family
AL537_06415	COG3706	GGDEF domain
AL537_06425	COG0469	pyruvate kinase activity
AL537_06435	COG1349	DNA-binding transcription factor activity
AL537_06440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL537_06455	COG5002	protein histidine kinase activity
AL537_06465	COG2376	Dihydroxyacetone kinase
AL537_06470	COG1461	Dihydroxyacetone kinase
AL537_06485	COG3722	fumarate hydratase activity
AL537_06495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_06495	COG2213	PTS system mannitol-specific
AL537_06540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL537_06545	COG0358	DNA primase activity
AL537_06550	COG1610	YqeY-like protein
AL537_06555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL537_06560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL537_06565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL537_06570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL537_06575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL537_06580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL537_06585	COG1968	undecaprenyl-diphosphatase activity
AL537_06590	COG0617	tRNA 3'-terminal CCA addition
AL537_06595	COG3267	Type II secretory pathway component ExeA
AL537_06595	COG3409	Peptidoglycan-binding domain 1 protein
AL537_06605	COG0405	Gamma-glutamyltransferase
AL537_06610	COG4991	sh3 domain protein
AL537_06615	COG0306	phosphate transporter
AL537_06620	COG1392	Phosphate transport regulator
AL537_06625	COG3025	triphosphatase activity
AL537_06640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL537_06645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL537_06645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL537_06650	COG1538	Outer membrane efflux protein
AL537_06655	COG0494	nUDIX hydrolase
AL537_06660	COG3151	Protein conserved in bacteria
AL537_06670	COG3150	esterase
AL537_06675	COG0187	DNA topoisomerase II activity
AL537_06680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL537_06685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL537_06695	COG3105	Protein conserved in bacteria
AL537_06705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL537_06715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL537_06720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL537_06725	COG0723	plastoquinol--plastocyanin reductase activity
AL537_06730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL537_06735	COG2857	Cytochrome c1
AL537_06740	COG0625	glutathione transferase activity
AL537_06745	COG2969	positive regulation of protein catabolic process
AL537_06750	COG2823	Periplasmic or secreted lipoprotein
AL537_06755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL537_06770	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL537_06785	COG3116	cell division
AL537_06790	COG0768	penicillin binding
AL537_06795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL537_06800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL537_06805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL537_06810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL537_06815	COG0772	Belongs to the SEDS family
AL537_06825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL537_06830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL537_06835	COG0849	cell division
AL537_06840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL537_06845	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL537_06855	COG0653	protein targeting
AL537_06860	COG0494	nUDIX hydrolase
AL537_06870	COG0505	Belongs to the CarA family
AL537_06875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL537_06895	COG0730	response to heat
AL537_06905	COG0583	DNA-binding transcription factor activity
AL537_06910	COG2860	membrane
AL537_06925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL537_06935	COG0493	'glutamate synthase
AL537_06940	COG0069	glutamate synthase activity
AL537_06940	COG0070	glutamate synthase
AL537_06940	COG0067	glutamate synthase
AL537_06950	COG0070	glutamate synthase
AL537_06950	COG0069	glutamate synthase activity
AL537_06950	COG0067	glutamate synthase
AL537_06955	COG1242	4 iron, 4 sulfur cluster binding
AL537_06960	COG2203	Gaf domain
AL537_06960	COG3706	GGDEF domain
AL537_06960	COG5001	Diguanylate cyclase
AL537_06960	COG4251	negative regulation of phosphorylation
AL537_06965	COG2198	Histidine kinase
AL537_06965	COG0784	Response regulator, receiver
AL537_06965	COG5002	protein histidine kinase activity
AL537_06975	COG0745	RESPONSE REGULATOR receiver
AL537_06990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL537_07010	COG0083	homoserine kinase activity
AL537_07015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL537_07025	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL537_07030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL537_07040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL537_07055	COG1115	amino acid carrier protein
AL537_07060	COG3022	response to hydroperoxide
AL537_07065	COG0513	Belongs to the DEAD box helicase family
AL537_07070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL537_07080	COG0716	FMN binding
AL537_07090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL537_07095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL537_07105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL537_07110	COG2204	response regulator
AL537_07120	COG0667	Aldo Keto reductase
AL537_07145	COG0730	response to heat
AL537_07155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL537_07165	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL537_07170	COG0583	DNA-binding transcription factor activity
AL537_07175	COG0640	Transcriptional regulator
AL537_07180	COG0268	Binds directly to 16S ribosomal RNA
AL537_07185	COG0728	peptidoglycan biosynthetic process
AL537_07190	COG0196	riboflavin kinase activity
AL537_07200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL537_07205	COG1047	Peptidyl-prolyl cis-trans
AL537_07210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL537_07220	COG3279	Response regulator of the LytR AlgR family
AL537_07225	COG3275	phosphorelay sensor kinase activity
AL537_07230	COG1966	Carbon starvation protein
AL537_07250	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL537_07255	COG1472	Belongs to the glycosyl hydrolase 3 family
AL537_07260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL537_07265	COG0287	Prephenate dehydrogenase
AL537_07265	COG1605	Chorismate mutase
AL537_07270	COG0739	heme binding
AL537_07270	COG0741	lytic transglycosylase activity
AL537_07270	COG1196	nuclear chromosome segregation
AL537_07280	COG0488	(ABC) transporter
AL537_07290	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL537_07295	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL537_07300	COG0077	Prephenate dehydratase
AL537_07300	COG1605	Chorismate mutase
AL537_07305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL537_07310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL537_07315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_07320	COG0564	pseudouridine synthase activity
AL537_07330	COG0542	response to heat
AL537_07390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL537_07400	COG2974	May be involved in recombination
AL537_07410	COG0745	RESPONSE REGULATOR receiver
AL537_07415	COG5002	protein histidine kinase activity
AL537_07425	COG0248	Ppx GppA phosphatase
AL537_07430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL537_07435	COG0573	inorganic phosphate transmembrane transporter activity
AL537_07440	COG0581	inorganic phosphate transmembrane transporter activity
AL537_07445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL537_07450	COG0704	Plays a role in the regulation of phosphate uptake
AL537_07460	COG3142	Participates in the control of copper homeostasis
AL537_07465	COG0450	alkyl hydroperoxide reductase
AL537_07470	COG0583	DNA-binding transcription factor activity
AL537_07475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL537_07485	COG0517	IMP dehydrogenase activity
AL537_07500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL537_07510	COG1862	Preprotein translocase
AL537_07515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_07520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_07525	COG0483	inositol monophosphate 1-phosphatase activity
AL537_07530	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL537_07540	COG1104	cysteine desulfurase activity
AL537_07545	COG0822	iron-sulfur transferase activity
AL537_07560	COG0443	Heat shock 70 kDa protein
AL537_07565	COG0633	Ferredoxin
AL537_07570	COG2975	iron-sulfur cluster assembly
AL537_07580	COG0105	UTP biosynthetic process
AL537_07600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL537_07605	COG0124	histidyl-tRNA synthetase
AL537_07610	COG2976	Protein conserved in bacteria
AL537_07615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_07620	COG1160	GTP binding
AL537_07640	COG0516	GMP reductase activity
AL537_07640	COG0517	IMP dehydrogenase activity
AL537_07645	COG0519	Catalyzes the synthesis of GMP from XMP
AL537_07645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL537_07650	COG1757	Na H antiporter
AL537_07660	COG1584	GPR1 FUN34 yaaH family protein
AL537_07665	COG1115	amino acid carrier protein
AL537_07690	COG2873	o-acetylhomoserine
AL537_07695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL537_07715	COG3153	acetyltransferase
AL537_07715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL537_07720	COG0583	DNA-binding transcription factor activity
AL537_07730	COG2801	Transposase and inactivated derivatives
AL537_07735	COG0583	DNA-binding transcription factor activity
AL537_07785	COG0210	DNA helicase
AL537_07820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL537_07845	COG0582	viral genome integration into host DNA
AL537_07855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL537_07860	COG2867	negative regulation of translational initiation
AL537_07865	COG2914	Belongs to the UPF0125 (RnfH) family
AL537_07870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_07875	COG0497	DNA recombination
AL537_07885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL537_07890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL537_07895	COG1301	dicarboxylic acid transport
AL537_07905	COG0484	heat shock protein binding
AL537_07940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL537_07945	COG0590	tRNA wobble adenosine to inosine editing
AL537_07955	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL537_07960	COG0047	phosphoribosylformylglycinamidine synthase activity
AL537_07960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL537_07975	COG1629	transport
AL537_07990	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL537_07995	COG2252	PERMEase
AL537_08000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL537_08015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL537_08020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL537_08025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL537_08030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_08030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_08055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL537_08060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL537_08065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL537_08070	COG0142	geranyltranstransferase activity
AL537_08075	COG1722	exodeoxyribonuclease VII activity
AL537_08080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL537_08090	COG0301	tRNA thio-modification
AL537_08090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_08095	COG0583	DNA-binding transcription factor activity
AL537_08105	COG2363	Small membrane protein
AL537_08115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_08120	COG1611	Belongs to the LOG family
AL537_08125	COG3706	GGDEF domain
AL537_08125	COG0745	RESPONSE REGULATOR receiver
AL537_08135	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL537_08135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL537_08145	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL537_08150	COG1464	Belongs to the NlpA lipoprotein family
AL537_08155	COG2011	ABC-type metal ion transport system permease component
AL537_08160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL537_08165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL537_08175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_08175	COG1263	PTS System
AL537_08180	COG0366	Alpha amylase catalytic
AL537_08195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL537_08200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL537_08205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL537_08210	COG0321	lipoyl(octanoyl) transferase activity
AL537_08220	COG1686	Belongs to the peptidase S11 family
AL537_08225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL537_08230	COG0772	Belongs to the SEDS family
AL537_08235	COG0768	penicillin binding
AL537_08240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL537_08245	COG0799	negative regulation of ribosome biogenesis
AL537_08250	COG1466	dna polymerase III delta subunit
AL537_08255	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL537_08260	COG0495	leucyl-tRNA aminoacylation
AL537_08265	COG2888	peptidyl-tyrosine sulfation
AL537_08270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL537_08275	COG4535	Mg2 and Co2 transporter CorC
AL537_08280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL537_08285	COG1702	phosphate starvation-inducible protein PhoH
AL537_08290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL537_08300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL537_08410	COG0012	GTP binding
AL537_08415	COG0193	aminoacyl-tRNA hydrolase activity
AL537_08420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL537_08425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL537_08430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL537_08435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL537_08445	COG2890	protein-(glutamine-N5) methyltransferase activity
AL537_08450	COG3094	Invasion gene expression up-regulator, SirB
AL537_08455	COG2912	Transglutaminase-like superfamily
AL537_08460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL537_08465	COG0737	Belongs to the 5'-nucleotidase family
AL537_08475	COG1187	pseudouridine synthase activity
AL537_08480	COG2840	Smr protein MutS2
AL537_08520	COG2217	Heavy metal translocating P-type atpase
AL537_08520	COG2608	mercury ion transmembrane transporter activity
AL537_08540	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL537_08595	COG0784	Response regulator, receiver
AL537_08595	COG0835	chemotaxis
AL537_08600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL537_08605	COG1815	bacterial-type flagellum-dependent cell motility
AL537_08610	COG1558	bacterial-type flagellum-dependent cell motility
AL537_08615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL537_08620	COG1749	Flagellar hook protein flgE
AL537_08625	COG4787	bacterial-type flagellum-dependent cell motility
AL537_08630	COG4786	Flagellar basal body rod
AL537_08635	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL537_08640	COG1706	bacterial-type flagellum-dependent cell motility
AL537_08645	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL537_08645	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL537_08655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_08660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_08675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_08680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_08685	COG2190	(PTS) system
AL537_08690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL537_08695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_08705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL537_08710	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL537_08715	COG3115	cell septum assembly
AL537_08720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL537_08745	COG0330	HflC and HflK could
AL537_08750	COG3118	belongs to the thioredoxin family
AL537_08760	COG0300	oxidoreductase activity
AL537_08765	COG1090	epimerase
AL537_08795	COG0622	Phosphoesterase
AL537_08815	COG3710	Transcriptional regulator
AL537_08820	COG0326	Molecular chaperone. Has ATPase activity
AL537_08830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL537_08835	COG3104	oligopeptide transport
AL537_08840	COG0250	Participates in transcription elongation, termination and antitermination
AL537_08845	COG0367	asparagine synthase
AL537_08850	COG4651	solute:proton antiporter activity
AL537_08850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL537_08855	COG1846	Transcriptional regulator
AL537_08855	COG1940	carbohydrate kinase activity
AL537_08860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL537_08870	COG2190	(PTS) system
AL537_08870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_08870	COG1263	PTS System
AL537_08875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL537_08880	COG0735	belongs to the Fur family
AL537_08890	COG0716	FMN binding
AL537_08900	COG0596	Alpha beta hydrolase
AL537_08905	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL537_08910	COG0033	Phosphoglucomutase
AL537_08920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL537_08930	COG2009	succinate dehydrogenase
AL537_08935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL537_08940	COG1053	succinate dehydrogenase
AL537_08945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL537_08950	COG0567	Dehydrogenase, E1 component
AL537_08955	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL537_08970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL537_08975	COG1121	(ABC) transporter
AL537_08980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL537_08985	COG4977	sequence-specific DNA binding
AL537_08990	COG1918	ferrous iron import across plasma membrane
AL537_09010	COG0018	arginyl-trna synthetase
AL537_09020	COG3102	Protein conserved in bacteria
AL537_09035	COG0788	formyltetrahydrofolate deformylase activity
AL537_09040	COG1199	ATP-dependent helicase activity
AL537_09045	COG1214	PFAM Peptidase M22, glycoprotease
AL537_09055	COG3065	identical protein binding
AL537_09060	COG2267	carboxylic ester hydrolase activity
AL537_09065	COG0318	PFAM AMP-dependent synthetase and ligase
AL537_09070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL537_09075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL537_09080	COG2894	cell division
AL537_09085	COG0850	regulation of cytokinetic process
AL537_09090	COG3100	YcgL domain-containing protein
AL537_09095	COG2951	lytic endotransglycosylase activity
AL537_09105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL537_09110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL537_09130	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_09135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL537_09140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL537_09165	COG2986	histidine ammonia-lyase
AL537_09170	COG1216	Glycosyl transferase, family 2
AL537_09175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL537_09190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL537_09195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL537_09230	COG1253	flavin adenine dinucleotide binding
AL537_09235	COG0513	Belongs to the DEAD box helicase family
AL537_09240	COG0569	domain protein
AL537_09245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_09260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL537_09265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL537_09270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL537_09275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL537_09300	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL537_09310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL537_09315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL537_09320	COG0776	regulation of translation
AL537_09325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL537_09330	COG1555	photosystem II stabilization
AL537_09345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL537_09350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL537_09355	COG0436	Aminotransferase
AL537_09360	COG1169	isochorismate synthase
AL537_09365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL537_09370	COG0596	Alpha beta hydrolase
AL537_09375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL537_09380	COG1441	menaquinone biosynthetic process
AL537_09395	COG2855	membrane
AL537_09400	COG0477	Major facilitator Superfamily
AL537_09445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_09450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_09475	COG1522	sequence-specific DNA binding
AL537_09485	COG1946	Acyl-CoA thioesterase
AL537_09490	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL537_09505	COG3706	GGDEF domain
AL537_09505	COG0745	RESPONSE REGULATOR receiver
AL537_09515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL537_09520	COG0516	GMP reductase activity
AL537_09520	COG0517	IMP dehydrogenase activity
AL537_09545	COG0537	adenosine 5'-monophosphoramidase activity
AL537_09570	COG3150	esterase
AL537_09575	COG1252	NADH dehydrogenase
AL537_09590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL537_09600	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL537_09605	COG1136	(ABC) transporter
AL537_09610	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL537_09620	COG0658	competence protein
AL537_09620	COG2333	competence protein COMEC
AL537_09625	COG1132	(ABC) transporter
AL537_09645	COG2719	SpoVR family
AL537_09650	COG2718	Belongs to the UPF0229 family
AL537_09655	COG2766	serine protein kinase
AL537_09665	COG3013	Belongs to the UPF0304 family
AL537_09675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL537_09685	COG1882	Formate acetyltransferase
AL537_09715	COG4215	(ABC) transporter
AL537_09730	COG0708	Exodeoxyribonuclease III
AL537_09740	COG3923	Primosomal replication protein n
AL537_09745	COG0730	response to heat
AL537_09750	COG1199	ATP-dependent helicase activity
AL537_09755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_09760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL537_09765	COG1187	pseudouridine synthase activity
AL537_09775	COG1278	Cold shock
AL537_09780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL537_09785	COG0542	response to heat
AL537_09790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL537_09795	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL537_09800	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL537_09820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL537_09825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL537_09830	COG0297	glycogen (starch) synthase activity
AL537_09850	COG3070	regulator of competence-specific genes
AL537_09855	COG1609	Transcriptional regulator
AL537_09860	COG3381	protein complex oligomerization
AL537_09865	COG0745	RESPONSE REGULATOR receiver
AL537_09870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL537_09875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_09880	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL537_09885	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL537_09890	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL537_09910	COG4067	protein conserved in archaea
AL537_09910	COG0189	ligase activity
AL537_09920	COG0500	methyltransferase
AL537_09930	COG1801	Protein of unknown function DUF72
AL537_09940	COG0217	transcriptional regulatory protein
AL537_09945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL537_09950	COG0632	four-way junction helicase activity
AL537_09955	COG2255	four-way junction helicase activity
AL537_09960	COG1271	oxidase subunit
AL537_09965	COG1294	oxidase, subunit
AL537_09970	COG4890	Cyd operon protein YbgT
AL537_09980	COG0824	Thioesterase
AL537_09985	COG0811	peptide transport
AL537_10000	COG0823	Involved in the tonB-independent uptake of proteins
AL537_10005	COG2885	chlorophyll binding
AL537_10010	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL537_10015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL537_10025	COG3766	membrane
AL537_10035	COG0754	glutathionylspermidine amidase activity
AL537_10045	COG5002	protein histidine kinase activity
AL537_10045	COG0784	Response regulator, receiver
AL537_10060	COG0840	transmembrane signaling receptor activity
AL537_10065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_10070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_10095	COG3568	Endonuclease Exonuclease Phosphatase
AL537_10105	COG0840	transmembrane signaling receptor activity
AL537_10120	COG0583	DNA-binding transcription factor activity
AL537_10130	COG0686	Belongs to the AlaDH PNT family
AL537_10140	COG1674	ftsk spoiiie
AL537_10145	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL537_10150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL537_10155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL537_10170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL537_10195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL537_10215	COG0300	oxidoreductase activity
AL537_10230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL537_10240	COG2268	Band 7 protein
AL537_10250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL537_10255	COG2915	High frequency lysogenization protein hflD homolog
AL537_10260	COG0482	sulfurtransferase activity
AL537_10270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_10280	COG1757	Na H antiporter
AL537_10290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL537_10295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL537_10300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL537_10305	COG0131	Imidazoleglycerol-phosphate dehydratase
AL537_10305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL537_10310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL537_10315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL537_10320	COG0107	imidazoleglycerol-phosphate synthase activity
AL537_10325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL537_10325	COG0140	phosphoribosyl-ATP diphosphatase activity
AL537_10330	COG3012	SEC-C Motif Domain Protein
AL537_10335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL537_10340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_10345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL537_10350	COG0215	cysteine-tRNA ligase activity
AL537_10355	COG1435	thymidine kinase activity
AL537_10360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL537_10385	COG2116	formate transmembrane transporter activity
AL537_10395	COG0390	transport system, permease component
AL537_10400	COG4459	periplasmic nitrate reductase
AL537_10405	COG3005	denitrification pathway
AL537_10410	COG0243	molybdopterin cofactor binding
AL537_10425	COG1227	inorganic diphosphatase activity
AL537_10435	COG4172	Belongs to the ABC transporter superfamily
AL537_10445	COG4171	peptide transport system, permease
AL537_10450	COG4168	peptide transport system, permease
AL537_10460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL537_10465	COG1842	Phage shock protein A
AL537_10475	COG1983	PspC domain protein
AL537_10495	COG2818	Glycosylase
AL537_10500	COG5380	lipid catabolic process
AL537_10505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL537_10510	COG0626	cystathionine gamma-synthase activity
AL537_10520	COG0733	neurotransmitter:sodium symporter activity
AL537_10525	COG0564	pseudouridine synthase activity
AL537_10535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL537_10540	COG1151	hydroxylamine reductase activity
AL537_10545	COG3604	Transcriptional regulator
AL537_10560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL537_10565	COG4136	ATPase activity
AL537_10570	COG4135	transport system, permease component
AL537_10575	COG4134	Bacterial extracellular solute-binding protein
AL537_10585	COG3313	Fe-S protein
AL537_10605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL537_10610	COG2205	protein histidine kinase activity
AL537_10615	COG0745	RESPONSE REGULATOR receiver
AL537_10625	COG1061	Type III restriction enzyme res subunit
AL537_10630	COG1187	pseudouridine synthase activity
AL537_10640	COG2814	Major facilitator Superfamily
AL537_10670	COG3005	denitrification pathway
AL537_10675	COG0702	epimerase
AL537_10680	COG0534	Mate efflux family protein
AL537_10700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL537_10710	COG1960	acyl-CoA dehydrogenase activity
AL537_10715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL537_10720	COG3273	potassium ion transport
AL537_10720	COG2985	domain, Protein
AL537_10725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL537_10735	COG1737	Transcriptional regulator
AL537_10740	COG0076	glutamate decarboxylase activity
AL537_10750	COG2431	L-lysine efflux transmembrane transporter activity
AL537_10765	COG3070	regulator of competence-specific genes
AL537_10780	COG4191	Histidine kinase
AL537_10780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_10790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL537_10800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL537_10805	COG4988	ABC transporter
AL537_10810	COG0492	ferredoxin-NADP+ reductase activity
AL537_10830	COG3706	GGDEF domain
AL537_10830	COG0745	RESPONSE REGULATOR receiver
AL537_10835	COG0471	metal ion transport
AL537_10840	COG2949	membrane
AL537_10845	COG0281	malic enzyme
AL537_10850	COG1643	Atp-dependent helicase
AL537_10865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL537_10900	COG0247	lactate metabolic process
AL537_10900	COG0277	FAD linked oxidase domain protein
AL537_10915	COG2986	histidine ammonia-lyase
AL537_10920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL537_10925	COG0010	Belongs to the arginase family
AL537_10930	COG1228	amidohydrolase
AL537_10935	COG2188	Transcriptional regulator
AL537_10950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL537_10960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL537_10970	COG0393	Putative heavy-metal-binding
AL537_11000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL537_11005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_11005	COG0072	phenylalanine-tRNA ligase activity
AL537_11015	COG0776	regulation of translation
AL537_11025	COG0500	methyltransferase
AL537_11030	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL537_11035	COG0295	cytidine deaminase activity
AL537_11040	COG1346	cytolysis
AL537_11045	COG1380	Effector of murein hydrolase LrgA
AL537_11050	COG2925	Exonuclease
AL537_11090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL537_11115	COG1484	DNA-dependent DNA replication
AL537_11265	COG0702	epimerase
AL537_11270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL537_11275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL537_11295	COG2988	succinylglutamate desuccinylase activity
AL537_11300	COG4139	cobalamin transport
AL537_11305	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL537_11325	COG0583	DNA-binding transcription factor activity
AL537_11335	COG1451	nucleotide metabolic process
AL537_11340	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AL537_11370	COG3938	Belongs to the proline racemase family
AL537_11385	COG2423	ornithine cyclodeaminase activity
AL537_11390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL537_11395	COG3842	ATPase activity
AL537_11400	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL537_11405	COG1177	transmembrane transport
AL537_11420	COG3291	Pkd domain containing protein
AL537_11435	COG0444	Belongs to the ABC transporter superfamily
AL537_11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_11445	COG0601	transmembrane transport
AL537_11455	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL537_11465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL537_11475	COG0625	glutathione transferase activity
AL537_11510	COG2200	EAL domain
AL537_11510	COG2771	luxR family
AL537_11520	COG1846	Transcriptional regulator
AL537_11525	COG2315	Protein conserved in bacteria
AL537_11540	COG0110	maltose O-acetyltransferase activity
AL537_11570	COG3063	Type IV pilus biogenesis stability protein PilW
AL537_11575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL537_11590	COG0531	amino acid
AL537_11595	COG1560	Kdo2-lipid A biosynthetic process
AL537_11600	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL537_11605	COG1280	lysine exporter protein (LysE YggA)
AL537_11615	COG1115	amino acid carrier protein
AL537_11640	COG1368	sulfuric ester hydrolase activity
AL537_11645	COG0642	Histidine kinase
AL537_11650	COG0745	RESPONSE REGULATOR receiver
AL537_11660	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_11680	COG2113	Glycine betaine
AL537_11685	COG4176	ABC-type proline glycine betaine transport system permease component
AL537_11705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_11710	COG0456	acetyltransferase
AL537_11715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL537_11720	COG0662	Cupin 2, conserved barrel domain protein
AL537_11725	COG0527	aspartate kinase activity
AL537_11730	COG3119	arylsulfatase activity
AL537_11745	COG0641	radical SAM
AL537_11760	COG1349	DNA-binding transcription factor activity
AL537_11765	COG0673	inositol 2-dehydrogenase activity
AL537_11770	COG4702	Belongs to the UPF0303 family
AL537_11795	COG0471	metal ion transport
AL537_11800	COG4191	Histidine kinase
AL537_11810	COG5001	Diguanylate cyclase
AL537_11810	COG3300	MHYT domain
AL537_11825	COG1328	CTP reductase activity
AL537_11830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL537_11840	COG0861	Integral membrane protein TerC family
AL537_11850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL537_11860	COG0814	amino acid
AL537_11875	COG1120	ATPase activity
AL537_11880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL537_11890	COG4774	siderophore transport
AL537_11900	COG1132	(ABC) transporter
AL537_11905	COG1132	(ABC) transporter
AL537_11910	COG4968	Prepilin-type N-terminal cleavage methylation domain
AL537_11930	COG0443	Heat shock 70 kDa protein
AL537_11935	COG0443	Heat shock 70 kDa protein
AL537_11980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL537_11985	COG1643	Atp-dependent helicase
AL537_12000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_12010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL537_12015	COG1215	transferase activity, transferring glycosyl groups
AL537_12020	COG0438	transferase activity, transferring glycosyl groups
AL537_12050	COG0438	transferase activity, transferring glycosyl groups
AL537_12060	COG2204	response regulator
AL537_12090	COG1793	dna ligase
AL537_12100	COG0534	Mate efflux family protein
AL537_12105	COG0307	riboflavin synthase, alpha
AL537_12125	COG3706	GGDEF domain
AL537_12135	COG0791	NLP P60 protein
AL537_12175	COG1940	carbohydrate kinase activity
AL537_12185	COG0303	'Molybdopterin
AL537_12190	COG0746	molybdenum cofactor guanylyltransferase activity
AL537_12195	COG3842	ATPase activity
AL537_12210	COG2204	response regulator
AL537_12215	COG4191	Histidine kinase
AL537_12225	COG0488	(ABC) transporter
AL537_12230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL537_12250	COG3381	protein complex oligomerization
AL537_12260	COG0243	molybdopterin cofactor binding
AL537_12260	COG3383	formate dehydrogenase (NAD+) activity
AL537_12265	COG0437	4 iron, 4 sulfur cluster binding
AL537_12290	COG0004	ammonium transporteR
AL537_12295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL537_12300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL537_12305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL537_12310	COG1177	transmembrane transport
AL537_12315	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL537_12320	COG3842	ATPase activity
AL537_12345	COG0589	response to stress
AL537_12350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_12365	COG2217	Heavy metal translocating P-type atpase
AL537_12375	COG2010	Cytochrome c
AL537_12390	COG3278	Belongs to the heme-copper respiratory oxidase family
AL537_12405	COG2205	protein histidine kinase activity
AL537_12405	COG0784	Response regulator, receiver
AL537_12615	COG3120	sequence-specific DNA binding
AL537_12620	COG1067	ATP-dependent peptidase activity
AL537_12625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL537_12650	COG0116	Belongs to the methyltransferase superfamily
AL537_12650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL537_12660	COG0167	dihydroorotate dehydrogenase activity
AL537_12665	COG2902	Dehydrogenase
AL537_12675	COG0308	aminopeptidase N
AL537_12810	COG4695	Portal protein
AL537_12890	COG1428	Deoxynucleoside kinase
AL537_12940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_12940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_12985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AL537_12990	COG0308	aminopeptidase N
AL537_13005	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL537_13010	COG1956	GAF domain-containing protein
AL537_13015	COG1132	(ABC) transporter
AL537_13020	COG2995	paraquat-inducible protein a
AL537_13025	COG3008	intermembrane lipid transfer
AL537_13050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL537_13055	COG1666	GTP binding
AL537_13070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_13075	COG4597	amino acid ABC transporter
AL537_13080	COG0765	amino acid transport
AL537_13085	COG1126	abc transporter atp-binding protein
AL537_13090	COG0670	Belongs to the BI1 family
AL537_13100	COG2920	part of a sulfur-relay system
AL537_13105	COG1254	Belongs to the acylphosphatase family
AL537_13155	COG3706	GGDEF domain
AL537_13160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL537_13165	COG0602	queuosine metabolic process
AL537_13170	COG0561	phosphatase activity
AL537_13195	COG2828	Protein conserved in bacteria
AL537_13205	COG0372	Belongs to the citrate synthase family
AL537_13210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL537_13245	COG0730	response to heat
AL537_13265	COG0457	Tetratricopeptide repeat
AL537_13330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL537_13335	COG4790	Type iii secretion
AL537_13340	COG4794	Type iii secretion
AL537_13345	COG4791	protein targeting
AL537_13350	COG4792	protein secretion
AL537_13375	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_13405	COG3177	Filamentation induced by cAMP protein fic
AL537_13425	COG4669	(LipO)protein
AL537_13495	COG1012	belongs to the aldehyde dehydrogenase family
AL537_13500	COG3284	Transcriptional regulator
AL537_13525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL537_13530	COG0363	glucosamine-6-phosphate deaminase activity
AL537_13535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL537_13540	COG4977	sequence-specific DNA binding
AL537_13550	COG4565	transcriptional regulatory protein
AL537_13555	COG3290	protein histidine kinase activity
AL537_13570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_13585	COG0583	DNA-binding transcription factor activity
AL537_13600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL537_13610	COG2985	domain, Protein
AL537_13640	COG2272	Belongs to the type-B carboxylesterase lipase family
AL537_13645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL537_13650	COG0729	surface antigen
AL537_13660	COG1280	lysine exporter protein (LysE YggA)
AL537_13670	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL537_13690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL537_13770	COG2200	EAL domain
AL537_13790	COG0697	spore germination
AL537_13815	COG3459	Glycosyltransferase 36 associated
AL537_13995	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL537_14045	COG2226	methyltransferase
AL537_14280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_14290	COG3768	UPF0283 membrane protein
AL537_14295	COG3106	COG3106 Predicted ATPase
AL537_14315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL537_14320	COG0784	Response regulator, receiver
AL537_14320	COG2205	protein histidine kinase activity
AL537_14330	COG0494	nUDIX hydrolase
AL537_14335	COG0814	amino acid
AL537_14340	COG1760	l-serine dehydratase
AL537_14345	COG2200	EAL domain
AL537_14355	COG0720	synthase
AL537_14360	COG3646	Phage regulatory protein
AL537_14380	COG3646	Phage regulatory protein
AL537_14590	COG0751	glycine-tRNA ligase activity
AL537_14625	COG5532	Uncharacterized conserved protein (DUF2303)
AL537_14650	COG1278	Cold shock
AL537_14655	COG0582	viral genome integration into host DNA
AL537_14675	COG3300	MHYT domain
AL537_14675	COG5001	Diguanylate cyclase
AL537_14680	COG0840	transmembrane signaling receptor activity
AL537_14685	COG0017	Asparaginyl-tRNA synthetase
AL537_14695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_14710	COG1448	Aminotransferase
AL537_14730	COG0840	transmembrane signaling receptor activity
AL537_14735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_14765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL537_14780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL537_14785	COG3108	Peptidase M15
AL537_14790	COG2989	Protein conserved in bacteria
AL537_14815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL537_14825	COG4235	cytochrome complex assembly
AL537_14825	COG3088	subunit of a heme lyase
AL537_14835	COG1138	Cytochrome C-type biogenesis protein
AL537_14840	COG3301	Polysulphide reductase, NrfD
AL537_14845	COG0437	4 iron, 4 sulfur cluster binding
AL537_14855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL537_14875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_14880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL537_14885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL537_14910	COG0019	diaminopimelate decarboxylase activity
AL537_14950	COG0322	excinuclease ABC activity
AL537_14955	COG2197	response regulator
AL537_14960	COG0417	DNA replication proofreading
AL537_14980	COG1187	pseudouridine synthase activity
AL537_14990	COG0009	L-threonylcarbamoyladenylate synthase
AL537_14995	COG0613	PHP domain protein
AL537_15005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL537_15010	COG0512	Glutamine amidotransferase of anthranilate synthase
AL537_15020	COG0135	phosphoribosylanthranilate isomerase activity
AL537_15020	COG0134	indole-3-glycerol-phosphate synthase activity
AL537_15030	COG0159	tryptophan synthase activity
AL537_15035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_15040	COG0318	PFAM AMP-dependent synthetase and ligase
AL537_15050	COG1301	dicarboxylic acid transport
AL537_15070	COG2917	probably involved in intracellular septation
AL537_15080	COG1607	acyl-coa hydrolase
AL537_15085	COG2350	Protein conserved in bacteria
AL537_15095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL537_15100	COG0583	DNA-binding transcription factor activity
AL537_15115	COG5001	Diguanylate cyclase
AL537_15120	COG1032	radical SAM domain protein
AL537_15135	COG0840	transmembrane signaling receptor activity
AL537_15145	COG0745	RESPONSE REGULATOR receiver
AL537_15150	COG3850	Histidine kinase
AL537_15150	COG5002	protein histidine kinase activity
AL537_15185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL537_15200	COG1335	isochorismatase
AL537_15205	COG1136	(ABC) transporter
AL537_15205	COG0577	efflux transmembrane transporter activity
AL537_15215	COG0577	efflux transmembrane transporter activity
AL537_15215	COG1136	(ABC) transporter
AL537_15225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_15255	COG3118	belongs to the thioredoxin family
AL537_15260	COG4232	protein-disulfide reductase activity
AL537_15295	COG2863	cytochrome
AL537_15300	COG3258	Cytochrome c
AL537_15305	COG2995	paraquat-inducible protein a
AL537_15310	COG3008	intermembrane lipid transfer
AL537_15310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL537_15325	COG4166	transmembrane transport
AL537_15335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL537_15340	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL537_15350	COG0539	negative regulation of cytoplasmic translation
AL537_15355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL537_15360	COG0616	signal peptide processing
AL537_15365	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_15380	COG0587	DNA-directed DNA polymerase activity
AL537_15385	COG0835	chemotaxis
AL537_15385	COG0784	Response regulator, receiver
AL537_15390	COG1940	carbohydrate kinase activity
AL537_15395	COG0469	pyruvate kinase activity
AL537_15400	COG4667	esterase of the alpha-beta hydrolase superfamily
AL537_15415	COG0733	neurotransmitter:sodium symporter activity
AL537_15425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_15425	COG1263	PTS System
AL537_15430	COG0084	hydrolase, TatD family'
AL537_15435	COG0470	DNA polymerase III
AL537_15440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL537_15445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL537_15475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL537_15480	COG0416	fatty acid biosynthetic process
AL537_15490	COG1399	metal-binding, possibly nucleic acid-binding protein
AL537_15495	COG0424	maF-like protein
AL537_15500	COG0564	pseudouridine synthase activity
AL537_15505	COG1530	ribonuclease E activity
AL537_15515	COG0659	secondary active sulfate transmembrane transporter activity
AL537_15520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL537_15525	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL537_15545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_15545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_15555	COG2186	Transcriptional regulator
AL537_15560	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL537_15565	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL537_15570	COG0653	protein targeting
AL537_15575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL537_15580	COG3706	GGDEF domain
AL537_15585	COG0366	Alpha amylase catalytic
AL537_15590	COG1122	ATPase activity
AL537_15595	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL537_15605	COG3092	negative regulation of chromosome organization
AL537_15610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL537_15615	COG0857	belongs to the CobB CobQ family
AL537_15615	COG0280	phosphate acetyltransferase
AL537_15620	COG3174	membrane
AL537_15630	COG0435	Glutathione S-transferase
AL537_15640	COG0444	Belongs to the ABC transporter superfamily
AL537_15645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_15650	COG0601	transmembrane transport
AL537_15660	COG0314	molybdopterin synthase activity
AL537_15665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL537_15670	COG0315	cyclic pyranopterin monophosphate synthase activity
AL537_15675	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL537_15680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL537_15685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL537_15690	COG2198	Histidine kinase
AL537_15695	COG2204	response regulator
AL537_15700	COG0556	nucleotide-excision repair
AL537_15715	COG4657	Part of a membrane complex involved in electron transport
AL537_15720	COG2878	Part of a membrane complex involved in electron transport
AL537_15725	COG4656	Part of a membrane complex involved in electron transport
AL537_15730	COG4658	electron transport chain
AL537_15735	COG4659	FMN binding
AL537_15740	COG4660	Part of a membrane complex involved in electron transport
AL537_15745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL537_15750	COG0346	lactoylglutathione lyase activity
AL537_15760	COG2885	chlorophyll binding
AL537_15770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL537_15775	COG2056	Na+-H+ antiporter family
AL537_15905	COG4695	Portal protein
AL537_16010	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL537_16015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL537_16035	COG1012	belongs to the aldehyde dehydrogenase family
AL537_16035	COG1454	alcohol dehydrogenase
AL537_16040	COG2095	MarC family integral membrane protein
AL537_16045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_16050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL537_16055	COG1757	Na H antiporter
AL537_16070	COG3081	Nucleoid-associated protein
AL537_16075	COG3082	Protein of unknown function (DUF1414)
AL537_16090	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL537_16105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL537_16110	COG0778	Nitroreductase
AL537_16120	COG1902	pentaerythritol trinitrate reductase activity
AL537_16120	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL537_16125	COG0616	signal peptide processing
AL537_16130	COG0252	asparaginase activity
AL537_16135	COG3139	Protein of unknown function (DUF1315)
AL537_16145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_16150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL537_16165	COG2226	methyltransferase
AL537_16185	COG1785	Belongs to the alkaline phosphatase family
AL537_16195	COG0346	lactoylglutathione lyase activity
AL537_16200	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL537_16205	COG0668	transmembrane transport
AL537_16210	COG2983	Belongs to the UPF0260 family
AL537_16215	COG2261	transglycosylase associated protein
AL537_16230	COG3681	Belongs to the UPF0597 family
AL537_16235	COG0251	oxidation-reduction process
AL537_16240	COG0814	amino acid
AL537_16245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL537_16250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL537_16255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL537_16265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL537_16270	COG2832	Protein of unknown function (DUF454)
AL537_16280	COG0745	RESPONSE REGULATOR receiver
AL537_16285	COG0583	DNA-binding transcription factor activity
AL537_16290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL537_16295	COG1286	toxin biosynthetic process
AL537_16300	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL537_16305	COG0285	dihydrofolate synthase activity
AL537_16310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL537_16320	COG0101	tRNA pseudouridine synthase activity
AL537_16330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL537_16335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL537_16345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL537_16350	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL537_16350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL537_16355	COG0431	NADPH-dependent FMN reductase
AL537_16370	COG3101	peptidyl-lysine hydroxylation
AL537_16380	COG2860	membrane
AL537_16385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL537_16390	COG2890	protein-(glutamine-N5) methyltransferase activity
AL537_16395	COG2840	Smr protein MutS2
AL537_16400	COG2062	phosphohistidine phosphatase, SixA
AL537_16415	COG1024	Enoyl-CoA hydratase
AL537_16415	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL537_16420	COG0183	Belongs to the thiolase family
AL537_16450	COG3088	subunit of a heme lyase
AL537_16450	COG4235	cytochrome complex assembly
AL537_16460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL537_16465	COG1138	Cytochrome C-type biogenesis protein
AL537_16470	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL537_16475	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL537_16480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL537_16485	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL537_16490	COG4133	protoheme IX ABC transporter activity
AL537_16500	COG0835	chemotaxis
AL537_16510	COG1192	Involved in chromosome partitioning
AL537_16515	COG2201	protein-glutamate methylesterase activity
AL537_16520	COG0643	Histidine kinase
AL537_16520	COG2198	Histidine kinase
AL537_16525	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL537_16540	COG0455	bacterial-type flagellum organization
AL537_16560	COG1684	flagellar biosynthetic protein fliR
AL537_16565	COG1987	bacterial-type flagellum assembly
AL537_16620	COG0745	RESPONSE REGULATOR receiver
AL537_16645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_16655	COG0463	Glycosyl transferase, family 2
AL537_16675	COG1136	(ABC) transporter
AL537_16695	COG1764	response to oxidative stress
AL537_16700	COG1846	Transcriptional regulator
AL537_16705	COG0450	alkyl hydroperoxide reductase
AL537_16710	COG3634	alkyl hydroperoxide reductase activity
AL537_16740	COG1595	DNA-templated transcription, initiation
AL537_16760	COG2258	MOSC domain
AL537_16785	COG2207	Transcriptional regulator
AL537_16795	COG1132	(ABC) transporter
AL537_16830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL537_16855	COG0259	pyridoxamine-phosphate oxidase activity
AL537_16910	COG4166	transmembrane transport
AL537_16930	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL537_16935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_16935	COG1263	PTS System
AL537_16940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_16945	COG3340	Belongs to the peptidase S51 family
AL537_16965	COG1444	tRNA N-acetyltransferase activity
AL537_16990	COG4608	Belongs to the ABC transporter superfamily
AL537_16995	COG0444	Belongs to the ABC transporter superfamily
AL537_17005	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AL537_17005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL537_17030	COG0772	Belongs to the SEDS family
AL537_17040	COG1136	(ABC) transporter
AL537_17060	COG3275	phosphorelay sensor kinase activity
AL537_17065	COG3279	Response regulator of the LytR AlgR family
AL537_17075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL537_17095	COG0786	glutamate:sodium symporter activity
AL537_17105	COG1131	(ABC) transporter
AL537_17110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_17115	COG0786	glutamate:sodium symporter activity
AL537_17125	COG0363	glucosamine-6-phosphate deaminase activity
AL537_17145	COG1741	Belongs to the pirin family
AL537_17150	COG2259	Doxx family
AL537_17160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL537_17165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL537_17175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL537_17200	COG0596	Alpha beta hydrolase
AL537_17215	COG3123	guanosine phosphorylase activity
AL537_17225	COG5001	Diguanylate cyclase
AL537_17230	COG0534	Mate efflux family protein
AL537_17235	COG0564	pseudouridine synthase activity
AL537_17250	COG0583	DNA-binding transcription factor activity
AL537_17255	COG0561	phosphatase activity
AL537_17265	COG2199	diguanylate cyclase activity
AL537_17280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL537_17285	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL537_17290	COG0583	DNA-binding transcription factor activity
AL537_17295	COG2375	cellular response to nickel ion
AL537_17330	COG1357	PFAM Pentapeptide repeats (8 copies)
AL537_17335	COG3047	cAMP biosynthetic process
AL537_17365	COG3408	Glycogen debranching enzyme
AL537_17365	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AL537_17370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AL537_17390	COG0583	DNA-binding transcription factor activity
AL537_17405	COG0546	phosphoglycolate phosphatase activity
AL537_17430	COG3835	regulator
AL537_17435	COG2610	gluconate transmembrane transporter activity
AL537_17440	COG1929	Belongs to the glycerate kinase type-1 family
AL537_17445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_17465	COG0456	acetyltransferase
AL537_17480	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_17485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_17490	COG3005	denitrification pathway
AL537_17495	COG0243	molybdopterin cofactor binding
AL537_17505	COG0352	thiamine-phosphate diphosphorylase activity
AL537_17510	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL537_17515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL537_17520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL537_17525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL537_17530	COG1116	anion transmembrane transporter activity
AL537_17535	COG0351	phosphomethylpyrimidine kinase
AL537_17540	COG0312	modulator of DNA gyrase
AL537_17545	COG0312	modulator of DNA gyrase
AL537_17550	COG1901	pseudouridine methyltransferase
AL537_17615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL537_17625	COG0584	glycerophosphoryl diester phosphodiesterase
AL537_17635	COG0745	RESPONSE REGULATOR receiver
AL537_17655	COG0811	peptide transport
AL537_17660	COG0811	peptide transport
AL537_17665	COG0848	biopolymer transport protein
AL537_17705	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL537_17710	COG1121	(ABC) transporter
AL537_17715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL537_17730	COG1770	oligopeptidase
AL537_17735	COG2814	Major facilitator Superfamily
AL537_17740	COG0010	Belongs to the arginase family
AL537_17745	COG1166	arginine decarboxylase activity
AL537_17755	COG4067	protein conserved in archaea
AL537_17755	COG0189	ligase activity
AL537_17760	COG0189	ligase activity
AL537_17765	COG0583	DNA-binding transcription factor activity
AL537_17800	COG4191	Histidine kinase
AL537_17805	COG2204	response regulator
AL537_17810	COG3706	GGDEF domain
AL537_17835	COG0579	oxidoreductase
AL537_17850	COG1294	oxidase, subunit
AL537_17855	COG1271	oxidase subunit
AL537_17865	COG3033	Beta-eliminating lyase
AL537_17885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL537_17900	COG3706	GGDEF domain
AL537_17920	COG3706	GGDEF domain
AL537_17925	COG0415	Belongs to the DNA photolyase family
AL537_17930	COG3046	protein related to deoxyribodipyrimidine photolyase
AL537_17945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_17945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_17950	COG1765	OsmC-like protein
AL537_17955	COG0110	maltose O-acetyltransferase activity
AL537_17995	COG1011	Hydrolase
AL537_18010	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL537_18020	COG2067	long-chain fatty acid transport protein
AL537_18025	COG3240	lipase activity
AL537_18055	COG1609	Transcriptional regulator
AL537_18060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_18075	COG1840	ABC-type Fe3 transport system, periplasmic component
AL537_18080	COG3842	ATPase activity
AL537_18105	COG2990	Protein conserved in bacteria
AL537_18115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL537_18120	COG2866	Carboxypeptidase
AL537_18130	COG0583	DNA-binding transcription factor activity
AL537_18155	COG1760	l-serine dehydratase
AL537_18175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL537_18180	COG0741	lytic transglycosylase activity
AL537_18200	COG1815	bacterial-type flagellum-dependent cell motility
AL537_18205	COG1558	bacterial-type flagellum-dependent cell motility
AL537_18210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL537_18215	COG1749	Flagellar hook protein flgE
AL537_18220	COG4787	bacterial-type flagellum-dependent cell motility
AL537_18225	COG4786	Flagellar basal body rod
AL537_18230	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL537_18235	COG1706	bacterial-type flagellum-dependent cell motility
AL537_18245	COG1256	bacterial-type flagellum assembly
AL537_18245	COG4786	Flagellar basal body rod
AL537_18250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_18270	COG1304	FMN binding
AL537_18285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_18290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL537_18295	COG0459	protein refolding
AL537_18325	COG1309	transcriptional regulator
AL537_18335	COG4303	Ethanolamine ammonia lyase large subunit
AL537_18340	COG4302	ethanolamine ammonia-lyase activity
AL537_18345	COG0531	amino acid
AL537_18350	COG2070	2-Nitropropane dioxygenase
AL537_18355	COG3537	Alpha-1,2-mannosidase
AL537_18360	COG3537	Alpha-1,2-mannosidase
AL537_18370	COG3537	Alpha-1,2-mannosidase
AL537_18375	COG3537	Alpha-1,2-mannosidase
AL537_18380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_18390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_18390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_18395	COG0346	lactoylglutathione lyase activity
AL537_18400	COG1349	DNA-binding transcription factor activity
AL537_18410	COG1335	isochorismatase
AL537_18420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL537_18445	COG0583	DNA-binding transcription factor activity
AL537_18460	COG3713	MltA-interacting MipA family protein
AL537_18465	COG3015	lipoprotein NlpE involved in copper resistance
AL537_18470	COG3448	diguanylate cyclase activity
AL537_18470	COG4175	Glycine betaine
AL537_18475	COG4176	ABC-type proline glycine betaine transport system permease component
AL537_18485	COG1342	Belongs to the UPF0251 family
AL537_18510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL537_18520	COG4948	Mandelate Racemase Muconate Lactonizing
AL537_18530	COG0583	DNA-binding transcription factor activity
AL537_18570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL537_18600	COG3842	ATPase activity
AL537_18630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_18650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL537_18655	COG2197	response regulator
AL537_18670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL537_18675	COG0252	asparaginase activity
AL537_18685	COG0583	DNA-binding transcription factor activity
AL537_18695	COG1280	lysine exporter protein (LysE YggA)
AL537_18700	COG3122	Protein conserved in bacteria
AL537_18710	COG2423	ornithine cyclodeaminase activity
AL537_18715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL537_18720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL537_18725	COG1012	belongs to the aldehyde dehydrogenase family
AL537_18730	COG1522	sequence-specific DNA binding
AL537_18735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL537_18740	COG3608	succinylglutamate desuccinylase aspartoacylase
AL537_18745	COG0006	proline dipeptidase activity
AL537_18750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_18755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL537_18760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL537_18765	COG2207	Transcriptional regulator
AL537_18770	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_18780	COG1063	alcohol dehydrogenase
AL537_18785	COG1902	pentaerythritol trinitrate reductase activity
AL537_18800	COG0583	DNA-binding transcription factor activity
AL537_18810	COG0513	Belongs to the DEAD box helicase family
AL537_18850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_18855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL537_18855	COG2207	Transcriptional regulator
AL537_18875	COG3746	phosphate-selective porin O and P
AL537_18890	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_18910	COG1263	PTS System
AL537_18910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_18915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_18920	COG1621	beta-fructofuranosidase activity
AL537_18930	COG0625	glutathione transferase activity
AL537_18945	COG1686	Belongs to the peptidase S11 family
AL537_18955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL537_18955	COG0678	peroxiredoxin activity
AL537_18960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL537_18975	COG1278	Cold shock
AL537_18980	COG1741	Belongs to the pirin family
AL537_18985	COG4667	esterase of the alpha-beta hydrolase superfamily
AL537_19005	COG2194	sulfuric ester hydrolase activity
AL537_19010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL537_19020	COG2205	protein histidine kinase activity
AL537_19025	COG0745	RESPONSE REGULATOR receiver
AL537_19040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL537_19060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL537_19070	COG2814	Major facilitator Superfamily
AL537_19085	COG1418	mRNA catabolic process
AL537_19090	COG0402	S-adenosylhomocysteine deaminase activity
AL537_19095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL537_19100	COG2239	Acts as a magnesium transporter
AL537_19105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL537_19110	COG1566	PFAM secretion protein HlyD family protein
AL537_19135	COG0745	RESPONSE REGULATOR receiver
AL537_19140	COG2205	protein histidine kinase activity
AL537_19155	COG0531	amino acid
AL537_19170	COG0583	DNA-binding transcription factor activity
AL537_19195	COG0784	Response regulator, receiver
AL537_19195	COG2205	protein histidine kinase activity
AL537_19195	COG5002	protein histidine kinase activity
AL537_19215	COG3132	Protein of unknown function, DUF480
AL537_19220	COG2827	Endonuclease containing a URI domain
AL537_19230	COG1879	ABC-type sugar transport system periplasmic component
AL537_19235	COG2205	protein histidine kinase activity
AL537_19235	COG0784	Response regulator, receiver
AL537_19295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_19300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_19310	COG1280	lysine exporter protein (LysE YggA)
AL537_19325	COG0183	Belongs to the thiolase family
AL537_19335	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL537_19345	COG3005	denitrification pathway
AL537_19355	COG0243	molybdopterin cofactor binding
AL537_19365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL537_19370	COG3850	Histidine kinase
AL537_19375	COG2197	response regulator
AL537_19390	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL537_19410	COG0840	transmembrane signaling receptor activity
AL537_19420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_19435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL537_19440	COG2814	Major facilitator Superfamily
AL537_19445	COG0840	transmembrane signaling receptor activity
AL537_19450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL537_19455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL537_19485	COG2897	thiosulfate sulfurtransferase activity
AL537_19505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL537_19520	COG1914	H( )-stimulated, divalent metal cation uptake system
AL537_19530	COG0038	chloride channel
AL537_19545	COG4989	oxidoreductase activity
AL537_19560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL537_19560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL537_19570	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL537_19615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_19630	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL537_19635	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL537_19635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL537_19645	COG0739	heme binding
AL537_19670	COG2204	response regulator
AL537_19685	COG3501	Rhs element vgr protein
AL537_19710	COG0515	serine threonine protein kinase
AL537_19745	COG1522	sequence-specific DNA binding
AL537_19860	COG2814	Major facilitator Superfamily
AL537_19870	COG0583	DNA-binding transcription factor activity
AL537_19875	COG4221	oxidoreductase activity
AL537_19880	COG0589	response to stress
AL537_19890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL537_19890	COG2111	Na H antiporter
AL537_19910	COG2212	antiporter activity
AL537_19915	COG1320	monovalent cation:proton antiporter activity
AL537_19920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL537_19985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_19990	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_20000	COG3527	Alpha-acetolactate decarboxylase
AL537_20010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_20025	COG1294	oxidase, subunit
AL537_20030	COG1271	oxidase subunit
AL537_20035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_20040	COG0110	maltose O-acetyltransferase activity
AL537_20055	COG2205	protein histidine kinase activity
AL537_20055	COG3437	response regulator, receiver
AL537_20055	COG3850	Histidine kinase
AL537_20055	COG4999	Histidine kinase
AL537_20075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL537_20080	COG1960	acyl-CoA dehydrogenase activity
AL537_20090	COG0183	Belongs to the thiolase family
AL537_20100	COG1960	acyl-CoA dehydrogenase activity
AL537_20105	COG1024	Enoyl-CoA hydratase
AL537_20120	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_20125	COG0745	RESPONSE REGULATOR receiver
AL537_20125	COG3706	GGDEF domain
AL537_20130	COG1309	transcriptional regulator
AL537_20135	COG1012	belongs to the aldehyde dehydrogenase family
AL537_20150	COG4176	ABC-type proline glycine betaine transport system permease component
AL537_20155	COG4175	Glycine betaine
AL537_20155	COG0517	IMP dehydrogenase activity
AL537_20170	COG0330	HflC and HflK could
AL537_20180	COG3300	MHYT domain
AL537_20180	COG5001	Diguanylate cyclase
AL537_20190	COG2205	protein histidine kinase activity
AL537_20190	COG0784	Response regulator, receiver
AL537_20200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL537_20250	COG5001	Diguanylate cyclase
AL537_20255	COG1869	D-ribose catabolic process
AL537_20260	COG1129	ABC transporter
AL537_20265	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL537_20270	COG1879	ABC-type sugar transport system periplasmic component
AL537_20275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_20280	COG1609	Transcriptional regulator
AL537_20295	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL537_20305	COG4607	ABC-type enterochelin transport system periplasmic component
AL537_20310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_20315	COG4605	iron ion homeostasis
AL537_20320	COG4604	ABC transporter, ATP-binding protein
AL537_20325	COG0789	Transcriptional regulator
AL537_20330	COG2207	Transcriptional regulator
AL537_20335	COG4771	TonB-dependent receptor
AL537_20335	COG1629	transport
AL537_20365	COG1289	transmembrane transporter activity
AL537_20370	COG0210	DNA helicase
AL537_20375	COG1803	Methylglyoxal synthase
AL537_20380	COG1879	ABC-type sugar transport system periplasmic component
AL537_20385	COG2205	protein histidine kinase activity
AL537_20385	COG0784	Response regulator, receiver
AL537_20385	COG2198	Histidine kinase
AL537_20405	COG3119	arylsulfatase activity
AL537_20415	COG3119	arylsulfatase activity
AL537_20420	COG0641	radical SAM
AL537_20425	COG0714	Associated with various cellular activities
AL537_20455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_20455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_20460	COG0583	DNA-binding transcription factor activity
AL537_20465	COG1597	lipid kinase activity
AL537_20470	COG3111	PFAM Bacterial OB fold (BOF) protein
AL537_20495	COG0501	Belongs to the peptidase M48B family
AL537_20500	COG1704	LemA family
AL537_20505	COG3069	C4-dicarboxylate transmembrane transporter activity
AL537_20515	COG0456	acetyltransferase
AL537_20515	COG1214	PFAM Peptidase M22, glycoprotease
AL537_20535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL537_20575	COG2003	Belongs to the UPF0758 family
AL537_20610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL537_20640	COG3121	Chaperone
AL537_20645	COG3188	usher protein
AL537_20665	COG0582	viral genome integration into host DNA
AL537_20670	COG3300	MHYT domain
AL537_20670	COG5001	Diguanylate cyclase
AL537_20675	COG3706	GGDEF domain
AL537_20685	COG2197	response regulator
AL537_20690	COG0784	Response regulator, receiver
AL537_20690	COG0835	chemotaxis
AL537_20705	COG2962	Rard protein
AL537_20735	COG2076	Multidrug Resistance protein
AL537_20765	COG0069	glutamate synthase activity
AL537_20765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL537_20770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL537_20795	COG1902	pentaerythritol trinitrate reductase activity
AL537_20800	COG0346	lactoylglutathione lyase activity
AL537_20825	COG2239	Acts as a magnesium transporter
AL537_20860	COG0242	peptide deformylase activity
AL537_20900	COG2176	DNA-directed DNA polymerase activity
AL537_20925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL537_20930	COG0697	spore germination
AL537_20940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL537_20950	COG0346	lactoylglutathione lyase activity
AL537_20955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL537_20955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL537_20960	COG0509	glycine decarboxylation via glycine cleavage system
AL537_20965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL537_20975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL537_20985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_21005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_21005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_21005	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL537_21010	COG1105	Belongs to the carbohydrate kinase PfkB family
AL537_21015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_21015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_21020	COG1609	Transcriptional regulator
AL537_21035	COG2203	Gaf domain
AL537_21035	COG2200	EAL domain
AL537_21035	COG2199	diguanylate cyclase activity
AL537_21040	COG0765	amino acid transport
AL537_21045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_21050	COG0765	amino acid transport
AL537_21055	COG1126	abc transporter atp-binding protein
AL537_21065	COG1979	alcohol dehydrogenase
AL537_21070	COG2207	Transcriptional regulator
AL537_21085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL537_21090	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL537_21095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_21110	COG0546	phosphoglycolate phosphatase activity
AL537_21130	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL537_21135	COG0513	Belongs to the DEAD box helicase family
AL537_21140	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL537_21155	COG3038	cytochrome b561
AL537_21160	COG2353	YceI-like domain
AL537_21165	COG2116	formate transmembrane transporter activity
AL537_21175	COG0583	DNA-binding transcription factor activity
AL537_21185	COG3593	DNA synthesis involved in DNA repair
AL537_21190	COG0737	Belongs to the 5'-nucleotidase family
AL537_21215	COG2267	carboxylic ester hydrolase activity
AL537_21220	COG2067	long-chain fatty acid transport protein
AL537_21235	COG2050	protein possibly involved in aromatic compounds catabolism
AL537_21245	COG4533	DNA binding
AL537_21280	COG1716	ATPase activity
AL537_21280	COG5001	Diguanylate cyclase
AL537_21285	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL537_21295	COG4181	ATPase activity
AL537_21300	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL537_21310	COG1984	allophanate hydrolase subunit 2
AL537_21315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL537_21320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL537_21325	COG3447	MASE1 domain protein
AL537_21325	COG5002	protein histidine kinase activity
AL537_21325	COG5001	Diguanylate cyclase
AL537_21330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL537_21345	COG0583	DNA-binding transcription factor activity
AL537_21350	COG0045	succinate-CoA ligase (ADP-forming) activity
AL537_21350	COG1042	CoA-binding domain protein
AL537_21350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_21365	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL537_21375	COG0023	Translation Initiation Factor
AL537_21380	COG4128	Pfam Zonular occludens toxin
AL537_21425	COG4128	Pfam Zonular occludens toxin
AL537_21590	COG0589	response to stress
AL537_21595	COG3140	Belongs to the UPF0181 family
AL537_21620	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL537_21625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL537_21640	COG0745	RESPONSE REGULATOR receiver
AL537_21640	COG3706	GGDEF domain
AL537_21650	COG3706	GGDEF domain
AL537_21650	COG2203	Gaf domain
AL537_21650	COG4251	negative regulation of phosphorylation
AL537_21650	COG5001	Diguanylate cyclase
AL537_21660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL537_21665	COG4149	molybdate abc transporter
AL537_21670	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL537_21680	COG3111	PFAM Bacterial OB fold (BOF) protein
AL537_21690	COG0189	ligase activity
AL537_21690	COG4067	protein conserved in archaea
AL537_21700	COG2207	Transcriptional regulator
AL537_21705	COG0534	Mate efflux family protein
AL537_21710	COG0602	queuosine metabolic process
AL537_21715	COG1328	CTP reductase activity
AL537_21730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_21760	COG1794	racemase activity, acting on amino acids and derivatives
AL537_21765	COG0384	phenazine biosynthesis protein PhzF
AL537_21775	COG0243	molybdopterin cofactor binding
AL537_21790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL537_21800	COG2197	response regulator
AL537_21805	COG3851	Histidine kinase
AL537_21810	COG2271	Major facilitator Superfamily
AL537_21835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL537_21840	COG3118	belongs to the thioredoxin family
AL537_21845	COG2814	Major facilitator Superfamily
AL537_21880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL537_21900	COG2116	formate transmembrane transporter activity
AL537_21905	COG2146	nitrite reductase [NAD(P)H] activity
AL537_21910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_21915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_21925	COG5001	Diguanylate cyclase
AL537_22145	COG1328	CTP reductase activity
AL537_22150	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AL537_22195	COG2176	DNA-directed DNA polymerase activity
AL537_22235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL537_22250	COG0277	FAD linked oxidase domain protein
AL537_22255	COG0583	DNA-binding transcription factor activity
AL537_22270	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL537_22285	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL537_22295	COG1288	antiporter activity
AL537_22305	COG3040	lipid binding
AL537_22315	COG0419	ATPase involved in DNA repair
AL537_22320	COG0420	3'-5' exonuclease activity
AL537_22335	COG3501	Rhs element vgr protein
AL537_22390	COG0631	protein serine/threonine phosphatase activity
AL537_22425	COG2815	serine threonine protein kinase
AL537_22425	COG0515	serine threonine protein kinase
AL537_22475	COG2146	nitrite reductase [NAD(P)H] activity
AL537_22475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_22480	COG1116	anion transmembrane transporter activity
AL537_22485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL537_22490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL537_22490	COG1116	anion transmembrane transporter activity
AL537_22500	COG3707	response regulator
AL537_22520	COG0243	molybdopterin cofactor binding
AL537_22530	COG0814	amino acid
AL537_22540	COG3706	GGDEF domain
AL537_22590	COG2847	Copper chaperone PCu(A)C
AL537_22595	COG0443	Heat shock 70 kDa protein
AL537_22645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL537_22645	COG2885	chlorophyll binding
AL537_22665	COG4160	amino acid transport
AL537_22670	COG4215	(ABC) transporter
AL537_22675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_22680	COG1126	abc transporter atp-binding protein
AL537_22710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_22720	COG1012	belongs to the aldehyde dehydrogenase family
AL537_22740	COG1902	pentaerythritol trinitrate reductase activity
AL537_22740	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL537_22745	COG0109	protoheme IX farnesyltransferase activity
AL537_22750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL537_22755	COG1845	cytochrome c oxidase, subunit III
AL537_22760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL537_22765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL537_22770	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_22780	COG1024	Enoyl-CoA hydratase
AL537_22785	COG1024	Enoyl-CoA hydratase
AL537_22800	COG0183	Belongs to the thiolase family
AL537_22810	COG1960	acyl-CoA dehydrogenase activity
AL537_22815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL537_22820	COG1024	Enoyl-CoA hydratase
AL537_22830	COG5413	integral membrane protein
AL537_22840	COG0277	FAD linked oxidase domain protein
AL537_22840	COG0247	lactate metabolic process
AL537_22895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL537_22910	COG0513	Belongs to the DEAD box helicase family
AL537_22915	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL537_22920	COG2207	Transcriptional regulator
AL537_22930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL537_22945	COG0840	transmembrane signaling receptor activity
AL537_22950	COG1119	ATPase activity
AL537_22955	COG2200	EAL domain
AL537_22975	COG0513	Belongs to the DEAD box helicase family
AL537_22980	COG0523	cobalamin synthesis protein
AL537_22990	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL537_23000	COG1278	Cold shock
AL537_23005	COG0557	exoribonuclease II activity
AL537_23010	COG0133	tryptophan synthase activity
AL537_23020	COG4628	conserved protein (DUF2132)
AL537_23025	COG0513	Belongs to the DEAD box helicase family
AL537_23035	COG0730	response to heat
AL537_23060	COG1278	Cold shock
AL537_23080	COG0330	HflC and HflK could
AL537_23095	COG0861	Integral membrane protein TerC family
AL537_23100	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_23110	COG3217	Mosc domain protein beta barrel domain protein
AL537_23110	COG0633	Ferredoxin
AL537_23120	COG0583	DNA-binding transcription factor activity
AL537_23125	COG0596	Alpha beta hydrolase
AL537_23135	COG2814	Major facilitator Superfamily
AL537_23140	COG3246	L-lysine catabolic process to acetate
AL537_23150	COG0183	Belongs to the thiolase family
AL537_23155	COG0113	porphobilinogen synthase activity
AL537_23180	COG1404	Belongs to the peptidase S8 family
AL537_23200	COG3530	Putative quorum-sensing-regulated virulence factor
AL537_23225	COG3186	Phenylalanine-4-hydroxylase
AL537_23230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL537_23235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_23260	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL537_23265	COG1454	alcohol dehydrogenase
AL537_23270	COG2133	pyrroloquinoline quinone binding
AL537_23280	COG0783	Belongs to the Dps family
AL537_23285	COG0840	transmembrane signaling receptor activity
AL537_23295	COG0577	efflux transmembrane transporter activity
AL537_23295	COG1136	(ABC) transporter
AL537_23315	COG2199	diguanylate cyclase activity
AL537_23320	COG3036	rescue of stalled ribosome
AL537_23325	COG1278	Cold shock
AL537_23355	COG0545	Peptidyl-prolyl cis-trans isomerase
AL537_23360	COG0109	protoheme IX farnesyltransferase activity
AL537_23365	COG1612	heme a metabolic process
AL537_23390	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL537_23395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL537_23400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL537_23405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL537_23415	COG1280	lysine exporter protein (LysE YggA)
AL537_23420	COG2207	Transcriptional regulator
AL537_23435	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL537_23455	COG0697	spore germination
AL537_23475	COG2814	Major facilitator Superfamily
AL537_23480	COG0583	DNA-binding transcription factor activity
AL537_23485	COG5001	Diguanylate cyclase
AL537_23490	COG0739	heme binding
AL537_23520	COG0840	transmembrane signaling receptor activity
AL537_23530	COG0814	amino acid
AL537_23545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL537_23550	COG1072	(Pantothenic acid kinase))
AL537_23560	COG1063	alcohol dehydrogenase
AL537_23565	COG2213	PTS system mannitol-specific
AL537_23570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_23585	COG0798	PFAM Bile acid sodium symporter
AL537_23595	COG1881	PFAM PEBP family protein
AL537_23605	COG2706	6-phosphogluconolactonase activity
AL537_23615	COG1131	(ABC) transporter
AL537_23620	COG0842	Transport permease protein
AL537_23635	COG3383	formate dehydrogenase (NAD+) activity
AL537_23660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_23690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_23700	COG2067	long-chain fatty acid transport protein
AL537_23710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_23720	COG1505	serine-type exopeptidase activity
AL537_23725	COG0488	(ABC) transporter
AL537_23730	COG0589	response to stress
AL537_23735	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL537_23755	COG0366	Alpha amylase catalytic
AL537_23760	COG0789	Transcriptional regulator
AL537_23780	COG4934	collagen metabolic process
AL537_23790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL537_23795	COG0583	DNA-binding transcription factor activity
AL537_23820	COG2610	gluconate transmembrane transporter activity
AL537_23825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL537_23830	COG3622	Belongs to the hyi family
AL537_23835	COG0235	Class ii aldolase
AL537_23840	COG3395	kinase activity
AL537_23845	COG2084	Dehydrogenase
AL537_23850	COG1349	DNA-binding transcription factor activity
AL537_23860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL537_23865	COG0784	Response regulator, receiver
AL537_23865	COG0835	chemotaxis
AL537_23875	COG0748	coenzyme F420 binding
AL537_23880	COG3721	Heme iron utilization protein
AL537_23890	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL537_23895	COG0811	peptide transport
AL537_23900	COG0848	biopolymer transport protein
AL537_23910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_23915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL537_23955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL537_23960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL537_23965	COG0633	Ferredoxin
AL537_23965	COG3217	Mosc domain protein beta barrel domain protein
AL537_23965	COG3217	Mosc domain protein beta barrel domain protein
AL537_23965	COG0633	Ferredoxin
AL537_23970	COG0401	homolog of Blt101
AL537_23980	COG0418	dihydroorotase activity
AL537_23985	COG2354	Protein conserved in bacteria
AL537_24015	COG0183	Belongs to the thiolase family
AL537_24110	COG0804	urea catabolic process
AL537_24130	COG0747	negative chemotaxis
AL537_24140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_24155	COG2207	Transcriptional regulator
AL537_24185	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL537_24265	COG4790	Type iii secretion
AL537_24275	COG3710	Transcriptional regulator
AL537_24305	COG4792	protein secretion
AL537_24310	COG4789	Type iii secretion
AL537_24445	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL537_24455	COG3344	reverse transcriptase
AL537_24570	COG3833	ABC-type maltose transport systems, permease component
AL537_24575	COG1175	transmembrane transport
AL537_24585	COG3842	ATPase activity
AL537_24590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL537_24605	COG3206	protein involved in exopolysaccharide biosynthesis
AL537_24605	COG0489	protein tyrosine kinase activity
AL537_24650	COG1309	transcriptional regulator
AL537_24655	COG2130	NADP-dependent
AL537_24665	COG0753	catalase activity
AL537_24670	COG2084	Dehydrogenase
AL537_24675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_24680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_24690	COG2207	Transcriptional regulator
AL537_24695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_24695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_24695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_24725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_24730	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL537_24735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL537_24745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL537_24750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_24770	COG0583	DNA-binding transcription factor activity
AL537_24775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_24780	COG0569	domain protein
AL537_24790	COG5002	protein histidine kinase activity
AL537_24795	COG1132	(ABC) transporter
AL537_24800	COG4774	siderophore transport
AL537_24805	COG1120	ATPase activity
AL537_24810	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL537_24845	COG2197	response regulator
AL537_24855	COG0840	transmembrane signaling receptor activity
AL537_24865	COG0714	Associated with various cellular activities
AL537_24880	COG2304	oxidoreductase activity
AL537_24885	COG2304	oxidoreductase activity
AL537_24900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL537_24905	COG0581	inorganic phosphate transmembrane transporter activity
AL537_24910	COG0573	inorganic phosphate transmembrane transporter activity
AL537_24915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL537_24945	COG1770	oligopeptidase
AL537_24950	COG0513	Belongs to the DEAD box helicase family
AL537_24960	COG1376	ErfK ybiS ycfS ynhG family protein
AL537_24960	COG1388	LysM domain
AL537_24965	COG0415	Belongs to the DNA photolyase family
AL537_24970	COG0789	Transcriptional regulator
AL537_24975	COG3272	Protein of unknown function (DUF1722)
AL537_24980	COG0813	purine-nucleoside phosphorylase activity
AL537_24995	COG3706	GGDEF domain
AL537_25005	COG1566	PFAM secretion protein HlyD family protein
AL537_25010	COG4720	Psort location CytoplasmicMembrane, score
AL537_25015	COG1122	ATPase activity
AL537_25035	COG0348	domain, Protein
AL537_25040	COG0437	4 iron, 4 sulfur cluster binding
AL537_25045	COG1247	-acetyltransferase
AL537_25065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_25070	COG0840	transmembrane signaling receptor activity
AL537_25075	COG1067	ATP-dependent peptidase activity
AL537_25085	COG4172	Belongs to the ABC transporter superfamily
AL537_25090	COG1505	serine-type exopeptidase activity
AL537_25095	COG0583	DNA-binding transcription factor activity
AL537_25100	COG1620	l-lactate permease
AL537_25105	COG1304	FMN binding
AL537_25115	COG0668	transmembrane transport
AL537_25150	COG1063	alcohol dehydrogenase
AL537_25155	COG0156	8-amino-7-oxononanoate synthase activity
AL537_25160	COG5001	Diguanylate cyclase
AL537_25160	COG3300	MHYT domain
AL537_25165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_25185	COG0745	RESPONSE REGULATOR receiver
AL537_25210	COG0346	lactoylglutathione lyase activity
AL537_25265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL537_25280	COG2204	response regulator
AL537_25305	COG1987	bacterial-type flagellum assembly
AL537_25315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL537_25330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_25350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL537_25355	COG1516	flagellar protein fliS
AL537_25370	COG1580	Controls the rotational direction of flagella during chemotaxis
AL537_25375	COG1191	sigma factor activity
AL537_25380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL537_25385	COG1360	Flagellar Motor Protein
AL537_25445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL537_25450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL537_25460	COG0454	-acetyltransferase
AL537_25470	COG2814	Major facilitator Superfamily
AL537_25515	COG0628	permease
AL537_25520	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL537_25535	COG4628	conserved protein (DUF2132)
AL537_25540	COG0583	DNA-binding transcription factor activity
AL537_25565	COG1686	Belongs to the peptidase S11 family
AL537_25590	COG0415	Belongs to the DNA photolyase family
AL537_25595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AL537_25600	COG3397	chitin binding
AL537_25605	COG4667	esterase of the alpha-beta hydrolase superfamily
AL537_25610	COG2095	MarC family integral membrane protein
AL537_25625	COG1596	polysaccharide export
AL537_25630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL537_25645	COG1301	dicarboxylic acid transport
AL537_25665	COG3339	Conserved Protein
AL537_25675	COG0700	Nucleoside recognition
AL537_25680	COG3366	ferrous iron transmembrane transporter activity
AL537_25695	COG0366	Alpha amylase catalytic
AL537_25700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL537_25705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL537_25710	COG1640	4-alpha-glucanotransferase
AL537_25715	COG0058	SHG alpha-glucan phosphorylase activity
AL537_25725	COG2909	trisaccharide binding
AL537_25740	COG1999	signal sequence binding
AL537_25745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_25745	COG1263	PTS System
AL537_25750	COG1162	GTPase activity
AL537_25755	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL537_25760	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL537_25770	COG0531	amino acid
AL537_25775	COG1982	Orn Lys Arg decarboxylase major
AL537_25795	COG2356	endonuclease I
AL537_25815	COG4580	involved in the transport of maltose and maltodextrins
AL537_25830	COG2814	Major facilitator Superfamily
AL537_25855	COG0739	heme binding
AL537_25865	COG0612	Peptidase, M16
AL537_25870	COG0840	transmembrane signaling receptor activity
AL537_25875	COG1120	ATPase activity
AL537_25880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_25885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_25890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL537_25895	COG4772	TonB-dependent receptor
AL537_25920	COG4264	IucA IucC family
AL537_25925	COG0019	diaminopimelate decarboxylase activity
AL537_25930	COG1653	transport