locus-tag class description AL468_00010 ENOG4105CGF Aromatic amino acid aminotransferase AL468_00025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_00035 ENOG4105C5S asparaginyl-tRNA synthetase AL468_00040 ENOG4105C8Q Methyl-accepting chemotaxis AL468_00045 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AL468_00055 ENOG4105BZU Histidine kinase AL468_00060 ENOG4105EJQ L-serine dehydratase AL468_00065 ENOG4105C44 Serine transporter AL468_00070 ENOG4105P8F nudix hydrolase AL468_00085 ENOG4105CRQ synthase (Component I) AL468_00105 ENOG4105CM6 amino acid regulated cytosolic protein AL468_00110 ENOG4106K28 UPF0283 membrane protein AL468_00120 ENOG4105D9U N-acetyltransferase AL468_00210 ENOG410822N TonB family AL468_00330 ENOG410822N TonB family AL468_00440 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AL468_00630 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL468_00850 ENOG4105RHY Pfam:UPF0157 AL468_01135 ENOG4108R6K riboflavin synthase, subunit alpha AL468_01260 ENOG4105DQ6 Transposase AL468_01350 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL468_01380 ENOG4105KCV RNA signal recognition particle 4.5S RNA AL468_01390 ENOG4105N14 lysine exporter protein LysE YggA AL468_01405 ENOG4105Y49 secretion protein, HlyD family AL468_01415 ENOG4105EQ2 LysR family Transcriptional regulator AL468_01425 ENOG4105Y49 secretion protein, HlyD family AL468_01440 ENOG4107KET secretion protein, HlyD family AL468_01455 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AL468_01460 ENOG4108V9W transcriptional regulatory protein AL468_01465 ENOG4105E0K tonB-dependent siderophore receptor AL468_01470 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF AL468_01475 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AL468_01480 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) AL468_01485 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AL468_01505 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AL468_01510 ENOG4105C26 Dehydrogenase AL468_01530 ENOG4108KB1 transcriptional regulator, arac family AL468_01560 ENOG41066XE Type III export protein AL468_01630 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL468_01655 ENOG41062JF Transcriptional regulator AL468_01770 ENOG4105EJ9 Membrane AL468_01805 ENOG4105CR4 methylisocitrate lyase AL468_01810 ENOG4105BZN citrate synthase AL468_01815 ENOG4108I0Z Aconitate hydratase AL468_01820 ENOG4105C7F AcnD-accessory protein PrpF AL468_01825 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_01835 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AL468_01845 ENOG410667J hydrolase AL468_01850 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AL468_01855 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AL468_01860 ENOG4105BZU Histidine kinase AL468_01870 ENOG4105CDV Ompa motb domain protein AL468_01885 ENOG4105CDV Ompa motb domain protein AL468_01900 ENOG4105DR4 Methyltransferase AL468_01905 ENOG4105C8Q Methyl-accepting chemotaxis AL468_01910 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AL468_01915 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AL468_01925 ENOG4108MN8 Membrane AL468_01930 ENOG4105CDA abc transporter atp-binding protein AL468_01935 ENOG4105DRP amino acid AbC transporter AL468_01940 ENOG4105EZ7 amino acid ABC transporter AL468_01945 ENOG4107QXX ABC transporter AL468_01960 ENOG4108VPT UPF0234 protein AL468_01965 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL468_01985 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL468_01990 ENOG4105DY2 Paraquat-inducible protein b AL468_01995 ENOG4105H2K paraquat-inducible protein a AL468_02000 ENOG4105BZ1 (ABC) transporter AL468_02005 ENOG4108ZGC gaf domain protein AL468_02010 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AL468_02015 ENOG4105CN1 protease AL468_02025 ENOG4105CD8 aminopeptidase N AL468_02035 ENOG4105C7I Dehydrogenase AL468_02040 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AL468_02045 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AL468_02050 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AL468_02060 ENOG4105C5H ABC transporter AL468_02075 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AL468_02080 ENOG4105DAN ATP-dependent protease AL468_02085 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) AL468_02115 ENOG4105BZU Histidine kinase AL468_02130 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AL468_02145 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) AL468_02155 ENOG4105C59 p-type ATPase AL468_02170 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL468_02175 ENOG4105Q9Y Universal stress protein AL468_02180 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AL468_02200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_02205 ENOG4105F38 ABC transporter, permease AL468_02210 ENOG4105D38 putrescine abc transporter AL468_02215 ENOG4107RUE extracellular solute-binding protein family 1 AL468_02220 ENOG4107RUE extracellular solute-binding protein family 1 AL468_02225 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AL468_02260 ENOG4105QAX Iron-sulfur AL468_02265 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL468_02275 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL468_02295 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL468_02300 ENOG4105C5H ABC transporter AL468_02310 ENOG4105BZU Histidine kinase AL468_02315 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_02330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_02335 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AL468_02340 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL468_02350 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AL468_02355 ENOG4106IUH DTW domain containing protein AL468_02390 ENOG4107TT5 NLP P60 protein AL468_02400 ENOG4105BZU Histidine kinase AL468_02410 ENOG4105FGM Fructosamine kinase AL468_02420 ENOG4108R6K riboflavin synthase, subunit alpha AL468_02425 ENOG4107QI1 Mate efflux family protein AL468_02440 ENOG41082AN stage II sporulation protein AL468_02450 ENOG4107V1M polysaccharide export protein AL468_02465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_02470 ENOG4107QPH glycogen) synthase AL468_02475 ENOG4107TYR Glycosyl Transferase AL468_02505 ENOG4105CPK Glycosyl transferase (Group 1 AL468_02510 ENOG4107R8N Glycosyl transferase, family 2 AL468_02525 ENOG4105C94 Transporter AL468_02540 ENOG4105CQ7 ATP-dependent helicase AL468_02545 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AL468_02590 ENOG4105CFG Acts as a chaperone (By similarity) AL468_02595 ENOG4105CFG Acts as a chaperone (By similarity) AL468_02615 ENOG4106855 Competence protein AL468_02620 ENOG4105BZ1 (ABC) transporter AL468_02625 ENOG4105BZ1 (ABC) transporter AL468_02635 ENOG4105E0K tonB-dependent siderophore receptor AL468_02640 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL468_02645 ENOG4105J76 Periplasmic binding protein AL468_02650 ENOG4105E0A ABC, transporter AL468_02660 ENOG4105CPI Metal Dependent Phosphohydrolase AL468_02665 ENOG4105E0U tyrosine-specific transport protein AL468_02675 ENOG4105DHT Metal Dependent Phosphohydrolase AL468_02685 ENOG4105EE5 Membrane protein terC AL468_02695 ENOG41076CZ activating enzyme AL468_02700 ENOG4105G0K glycine radical enzyme YjjI family AL468_02705 ENOG410829K Lysine exporter protein (Lyse ygga) AL468_02710 ENOG4105CPI Metal Dependent Phosphohydrolase AL468_02715 ENOG4105BZU Histidine kinase AL468_02720 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_02730 ENOG4105C8P )-transporter AL468_02750 ENOG4105BZU Histidine kinase AL468_02755 ENOG41090KN UPF0303 protein AL468_02760 ENOG4105D9R oxidoreductase AL468_02765 ENOG4105E98 transcriptional regulator DeoR family AL468_02780 ENOG4105C4X radical SAM domain protein AL468_02795 ENOG4105ENH Sulfatase AL468_02800 ENOG4105CZK Aspartate kinase AL468_02805 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AL468_02810 ENOG4108JPW Aminotransferase AL468_02815 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase AL468_02820 ENOG4105C94 Transporter AL468_02835 ENOG4108IJ7 Glycine betaine AL468_02840 ENOG4108HQS Glycine betaine AL468_02845 ENOG4105GIJ Glycine betaine AL468_02880 ENOG4105DHQ Histidine kinase AL468_02885 ENOG4105E0M Sulfatase AL468_02910 ENOG4105BZG amino acid carrier protein AL468_02920 ENOG410829K Lysine exporter protein (Lyse ygga) AL468_02925 ENOG4105CTD carboxy-peptidase AL468_02930 ENOG4105D1S lipid A biosynthesis AL468_02935 ENOG4105E5D amino acid AL468_02950 ENOG4105CVG Homoserine O-transsuccinylase AL468_02955 ENOG41090FY type IV pilus biogenesis stability protein PilW AL468_02965 ENOG4105BZU Histidine kinase AL468_02970 ENOG4105BZU Histidine kinase AL468_02985 ENOG4108UW5 maltose o-acetyltransferase AL468_03000 ENOG4105MSB protein, conserved in bacteria AL468_03005 ENOG4108ZT1 Transcriptional regulator AL468_03015 ENOG4105BZU Histidine kinase AL468_03050 ENOG4108RXX maleylacetoacetate isomerase AL468_03060 ENOG4105F1J Homogentisate 1,2-dioxygenase AL468_03065 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AL468_03070 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL468_03075 ENOG4107QSI ABC, transporter AL468_03080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL468_03085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_03090 ENOG4105C3U ABC transporter AL468_03095 ENOG4108JQ7 (ABC) transporter AL468_03105 ENOG4107MM9 BNR Asp-box repeat-containing protein AL468_03115 ENOG4105D38 putrescine abc transporter AL468_03120 ENOG4105F38 ABC transporter, permease AL468_03125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_03130 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL468_03135 ENOG4105CIF Ornithine Cyclodeaminase AL468_03150 ENOG4105CTU Proline racemase AL468_03180 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AL468_03185 ENOG4108VKG metal-dependent hydrolase AL468_03195 ENOG4105F04 LysR family Transcriptional regulator AL468_03215 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AL468_03220 ENOG4108IU2 vtamin B12-transporter permease AL468_03225 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AL468_03245 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AL468_03250 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AL468_03255 ENOG4105K4T epimerase AL468_03260 ENOG4108ETY sodium dicarboxylate symporter AL468_03265 ENOG4105CJB Exodeoxyribonuclease I AL468_03270 ENOG4105VAW lrga family AL468_03275 ENOG41067MG lrgb family AL468_03280 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) AL468_03285 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AL468_03290 ENOG4105FQ6 thiopurine methyltransferase AL468_03300 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL468_03310 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AL468_03315 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AL468_03345 ENOG4105K8R UPF0145 protein AL468_03350 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AL468_03355 ENOG41082NX 50s ribosomal protein l35 AL468_03360 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AL468_03365 ENOG4105C22 threonyL-tRNA synthetase AL468_03380 ENOG4105CZE histidine utilization repressor AL468_03385 ENOG4105CI2 imidazolone-5-propionate hydrolase AL468_03390 ENOG41088SP formiminoglutamate hydrolase AL468_03400 ENOG4105C84 Histidine ammonia-lyase AL468_03415 ENOG4105CQB FAD linked oxidase domain protein AL468_03430 ENOG4105CDV Ompa motb domain protein AL468_03450 ENOG4105C8V SAICAR synthetase AL468_03465 ENOG4105CQ7 ATP-dependent helicase AL468_03470 ENOG4107R1I NAD-dependent malic enzyme AL468_03475 ENOG4107GZ4 SanA protein AL468_03480 ENOG4105C8P )-transporter AL468_03485 ENOG4105BZU Histidine kinase AL468_03505 ENOG4105C3M thioredoxin reductase AL468_03510 ENOG4108JJ9 ABC, transporter AL468_03515 ENOG4108JJ8 (ABC) transporter AL468_03520 ENOG4105BZC d-serine deaminase AL468_03525 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AL468_03535 ENOG4105BZU Histidine kinase AL468_03565 ENOG4105DWU Membrane AL468_03575 ENOG4105DY8 decarboxylase AL468_03580 ENOG4106KNT transcriptional regulator AL468_03595 ENOG41090BQ Glutaredoxin AL468_03600 ENOG4105D0C transport protein AL468_03605 ENOG4105RKW reductase (By AL468_03610 ENOG4107QPN acyl-Coa dehydrogenase AL468_03615 ENOG41067SE Tetr family transcriptional regulator AL468_03625 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AL468_03650 ENOG4105CGD Nad-dependent epimerase dehydratase AL468_03655 ENOG4105CUW cytochrome C-TYPE protein AL468_03685 ENOG4105C2C drug resistance transporter, Bcr CflA AL468_03695 ENOG4105I08 Pseudouridine synthase AL468_03700 ENOG4105CFI type iii restriction protein res subunit AL468_03710 ENOG4105ETX regulatoR AL468_03715 ENOG4105EB3 Histidine kinase AL468_03725 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AL468_03735 ENOG4105CGH 5'-nucleotidase AL468_03745 ENOG4105XZD Fe-S protein AL468_03755 ENOG4105VNH ABC transporter solute-binding protein AL468_03760 ENOG4105CXZ ABC transporter, permease AL468_03765 ENOG4108VGW abc transporter atp-binding protein AL468_03770 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AL468_03785 ENOG4108JUA Transcriptional regulator AL468_03790 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AL468_03795 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL468_03805 ENOG4108W1A pseudouridine synthase AL468_03810 ENOG4105C8J )-transporter AL468_03815 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AL468_03820 ENOG4105C28 cystathionine AL468_03825 ENOG4107IFA Lipase (EC 3.1.1.3) AL468_03835 ENOG4108R3E Dna-3-methyladenine glycosylase i AL468_03855 ENOG4105FM1 phage shock protein C AL468_03860 ENOG4105YYT phage shock protein B AL468_03865 ENOG41087YS Phage shock protein A AL468_03870 ENOG4105E51 psp operon transcriptional activator AL468_03875 ENOG4108J59 Extracellular solute-binding protein, family 5 AL468_03880 ENOG4108I5W peptide transport system, permease protein AL468_03885 ENOG4108EU3 peptide transport system, permease AL468_03890 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AL468_03895 ENOG4108JQ2 peptide transport system atp-binding protein AL468_03905 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AL468_03920 ENOG4108J2R molybdopterin oxidoreductase AL468_03945 ENOG4105TMB Formate nitrite transporter AL468_03970 ENOG4107DB1 DUF218 domain AL468_03975 ENOG4107104 thymidine kinase AL468_03980 ENOG4105C8N cysteinyl-tRNA synthetase AL468_03985 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL468_03990 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AL468_03995 ENOG4105D58 Diguanylate phosphodiesterase AL468_04000 ENOG4105K5B UPF0225 protein AL468_04025 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AL468_04030 ENOG4105CIH Imidazole acetol-phosphate transaminase AL468_04035 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AL468_04040 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AL468_04045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_04050 ENOG4107S6Z Na H antiporter AL468_04055 ENOG4108YX2 DNA-binding protein AL468_04060 ENOG4107RE1 Inosine-guanosine kinase AL468_04070 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AL468_04075 ENOG41075W9 High frequency lysogenization protein HflD homolog AL468_04080 ENOG4107QTF adenylosuccinate lyase AL468_04090 ENOG4105RHG AL468_04100 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AL468_04115 ENOG4107FW0 short-chain dehydrogenase reductase AL468_04125 ENOG4105D0M Protease HtpX homolog AL468_04135 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AL468_04145 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL468_04150 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AL468_04170 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AL468_04175 ENOG4105D1H recombination factor protein RarA AL468_04180 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AL468_04185 ENOG4105CNU cell division protein FtsK AL468_04190 ENOG4105EW9 transcriptional regulator AsnC family AL468_04195 ENOG4105DCF alanine dehydrogenase AL468_04205 ENOG4107R11 Transcriptional regulator AL468_04215 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AL468_04220 ENOG4105C8Q Methyl-accepting chemotaxis AL468_04255 ENOG4105BZS acriflavin resistance protein AL468_04260 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL468_04265 ENOG4105C8Q Methyl-accepting chemotaxis AL468_04275 ENOG4108RNS Exports L-alanine (By similarity) AL468_04280 ENOG4105BZU Histidine kinase AL468_04290 ENOG4106032 Glutathionylspermidine synthase AL468_04300 ENOG4105Z6B inner membrane protein yjfl AL468_04310 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AL468_04315 ENOG4105UFD tol-pal system protein YbgF AL468_04320 ENOG4105KCK Peptidoglycan-associated lipoprotein AL468_04325 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AL468_04335 ENOG4105M8F Biopolymer transport protein exbD tolR AL468_04340 ENOG4105E02 MotA TolQ exbB proton channel AL468_04345 ENOG4107YD3 Thioesterase AL468_04360 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL468_04365 ENOG4105C4M (Ubiquinol oxidase) subunit I AL468_04370 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AL468_04375 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AL468_04380 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AL468_04385 ENOG4105CDY transcriptional regulatory protein AL468_04390 ENOG4105C9M aspartyl-trna synthetase AL468_04395 ENOG41081XQ Conserved Protein AL468_04400 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AL468_04405 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AL468_04415 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_04435 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AL468_04440 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AL468_04445 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) AL468_04450 ENOG4106371 Methyltransferase AL468_04455 ENOG4107S90 membrAne AL468_04460 ENOG4106WF9 DNA-binding transcriptional regulator TorR AL468_04465 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL468_04470 ENOG4105ETE Transcriptional regulator (LacI family AL468_04475 ENOG4105HP8 regulator of competence-specific genes AL468_04495 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AL468_04500 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL468_04505 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL468_04510 ENOG4105RKX Protein of unknown function (DUF2498) AL468_04515 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AL468_04525 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AL468_04530 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AL468_04535 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AL468_04540 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_04545 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AL468_04550 ENOG4105VEQ Cold shock protein AL468_04560 ENOG4108R99 pseudouridine synthase AL468_04570 ENOG4105SDR Outer membrane protein OmpT AL468_04575 ENOG4105DVT helicase AL468_04580 ENOG4105EJ9 Membrane AL468_04585 ENOG4108URS primosomal replication protein n'' AL468_04590 ENOG4106428 Protein of unknown function (DUF2496) AL468_04595 ENOG4105CGK Exodeoxyribonuclease III AL468_04610 ENOG4105DSP amino acid AbC transporter AL468_04615 ENOG4105E89 ABC transporter AL468_04620 ENOG4108JEH abc transporter atp-binding protein AL468_04640 ENOG4105C6N Formate acetyltransferase AL468_04650 ENOG4105F1A Pyruvate formate-lyase AL468_04660 ENOG4105XWI UPF0304 protein AL468_04670 ENOG4105CYN Serine protein kinase AL468_04675 ENOG4106AKX UPF0229 protein AL468_04680 ENOG4105ED1 spovr family AL468_04685 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AL468_04690 ENOG4105W49 UPF0434 protein AL468_04695 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AL468_04700 ENOG4105BZ1 (ABC) transporter AL468_04705 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AL468_04715 ENOG4105D60 lipoprotein releasing system transmembrane protein AL468_04720 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AL468_04725 ENOG4105D60 lipoprotein releasing system transmembrane protein AL468_04735 ENOG4108JA2 transcriptioN-repair coupling factor AL468_04750 ENOG4105CEP NADH dehydrogenase AL468_04755 ENOG4105D0Y UPF0227 protein AL468_04780 ENOG4105K59 histidine triad (HIT) protein AL468_04785 ENOG4108NVR Methyl-accepting chemotaxis AL468_04795 ENOG4107SXA Phosphorylase AL468_04805 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL468_04820 ENOG4105BZU Histidine kinase AL468_04835 ENOG4108MNP Glycoprotein polysaccharide metabolism AL468_04840 ENOG4105C29 acyl-CoA thioesterase AL468_04850 ENOG4108XM1 transcriptional regulator AsnC family AL468_04875 ENOG4105BZS acriflavin resistance protein AL468_04880 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AL468_04925 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL468_04930 ENOG4105HMI Membrane AL468_04940 ENOG4105CEY Amp-dependent synthetase and ligase AL468_04945 ENOG4105DNI Converts SHCHC to OSB (By similarity) AL468_04950 ENOG4108IPT Naphthoate synthase AL468_04955 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AL468_04960 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AL468_04965 ENOG4105E4F Isochorismate synthase AL468_04970 ENOG4105CHM Aminotransferase AL468_04975 ENOG4105DK2 UPF0207 protein AL468_04980 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AL468_04995 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AL468_05000 ENOG4105EIN peptidylprolyl cis-trans isomerase AL468_05005 ENOG4105K70 DNA-binding protein AL468_05010 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AL468_05015 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AL468_05020 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AL468_05025 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AL468_05035 ENOG4105CQZ Histidine kinase AL468_05040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_05050 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL468_05055 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ AL468_05060 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL468_05065 ENOG4105CNG UPF0061 protein AL468_05085 ENOG4107ZYR domain protein AL468_05090 ENOG4105C1J atp-dependent rna helicase AL468_05130 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL468_05145 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_05150 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL468_05155 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AL468_05160 ENOG4105C84 Histidine ammonia-lyase AL468_05185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_05190 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL468_05195 ENOG4105C2D reductase AL468_05200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_05265 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AL468_05270 ENOG4105D9N nucleoside AL468_05280 ENOG4105CVE Lytic murein transglycosylase AL468_05285 ENOG4105VNG YcgL domain-containing protein AL468_05290 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AL468_05295 ENOG4107QMS site-determining protein AL468_05300 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AL468_05305 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AL468_05310 ENOG4105CEY Amp-dependent synthetase and ligase AL468_05315 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_05320 ENOG4105R8X Outer membrane lipoprotein Slp AL468_05330 ENOG41072GX Peptidase M22 Glycoprotease AL468_05335 ENOG4105DVT helicase AL468_05340 ENOG4105CIY formyltetrahydrofolate deformylase AL468_05345 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AL468_05355 ENOG4106ZCM YecM protein AL468_05365 ENOG4105C75 arginyL-tRNA synthetase AL468_05385 ENOG4105XFK Ferrous iron transport protein A AL468_05390 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AL468_05395 ENOG4105NXV High-affinity zinc uptake system protein AL468_05400 ENOG4105FDK ABC transporter AL468_05405 ENOG4105FAV ABC, transporter AL468_05410 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AL468_05415 ENOG4105CMV Succinyl-CoA synthetase subunit beta AL468_05420 ENOG4105C7S Dehydrogenase AL468_05425 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AL468_05430 ENOG4105E33 succinate dehydrogenase AL468_05435 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AL468_05440 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AL468_05445 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AL468_05450 ENOG4105BZN citrate synthase AL468_05455 ENOG4107QNR UPF0135 protein AL468_05465 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AL468_05470 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AL468_05475 ENOG4105EV9 Alpha Beta Hydrolase AL468_05485 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AL468_05495 ENOG41090R7 Ferric uptake AL468_05500 ENOG4105CX6 glutaminyL-tRNA synthetase AL468_05505 ENOG4105CI1 PTS System AL468_05515 ENOG4105CE4 GlcNAc 6-P deacetylase AL468_05520 ENOG4105E2R ROK family AL468_05525 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL468_05530 ENOG4105CAQ asparagine synthetase AL468_05535 ENOG4105MDZ Transcriptional activator rfaH AL468_05540 ENOG4105DUX Transporter AL468_05545 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AL468_05550 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AL468_05555 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AL468_05560 ENOG4108DQ1 activator toxR AL468_05580 ENOG4108RE9 Phosphodiesterase AL468_05610 ENOG4105ECP epimerase AL468_05615 ENOG4105E1F short-chain dehydrogenase reductase AL468_05625 ENOG4107QR8 Thioredoxin AL468_05630 ENOG4107QX8 SPFH domain, Band 7 family protein AL468_05655 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AL468_05660 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AL468_05665 ENOG4105EXN Sulfate transport protein CysZ AL468_05670 ENOG4105C6T cysteine synthase AL468_05680 ENOG4105KZ7 phosphocarrier protein hpr AL468_05685 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AL468_05690 ENOG4105C5Y PTS System AL468_05700 ENOG4105I03 Flagellin AL468_05710 ENOG4105I03 Flagellin AL468_05715 ENOG4105DTJ flagellar hook-associated protein AL468_05725 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL468_05730 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_05735 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_05740 ENOG4105CGA flagellar basal-body rod protein FlgG AL468_05745 ENOG4108KPB Flagellar basal-body rod protein FlgF AL468_05750 ENOG4105BZE flagellar hook protein, FlgE AL468_05755 ENOG4105W00 Flagellar hook capping protein AL468_05760 ENOG4108ZC9 flagellar basal-body rod protein flgc AL468_05765 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL468_05770 ENOG4105BZU Histidine kinase AL468_05775 ENOG4107R88 Chemotaxis protein (CheV) AL468_05820 ENOG4105UYK outer membrane protein a AL468_05825 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AL468_05835 ENOG41081QG Porin Gram-negative type AL468_05850 ENOG4105C59 p-type ATPase AL468_05865 ENOG4105E2D ec 3.2.1.52 AL468_05890 ENOG4108DG9 Smr protein MutS2 AL468_05895 ENOG4105FE9 pseudouridine synthase AL468_05900 ENOG4108Z66 YbaK ebsC protein AL468_05905 ENOG4105CGH 5'-nucleotidase AL468_05910 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AL468_05915 ENOG41063JG Transcriptional regulator AL468_05920 ENOG4108YY7 Invasion gene expression up-regulator SirB AL468_05925 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AL468_05930 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AL468_05935 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AL468_05940 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AL468_05945 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AL468_05950 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AL468_05955 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AL468_05960 ENOG4105C3G gtp-binding protein AL468_06070 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL468_06080 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AL468_06085 ENOG4105C9A Phoh family AL468_06090 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AL468_06095 ENOG4108JU5 Magnesium and cobalt efflux protein AL468_06100 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AL468_06105 ENOG4107PAI alpha helical protein AL468_06110 ENOG4105C8T Leucyl-tRNA synthetase AL468_06115 ENOG4108U2H Rare lipoprotein B AL468_06120 ENOG4105DJF DNA polymerase III, delta' subunit AL468_06125 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AL468_06130 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AL468_06135 ENOG4105CJN penicillin-binding protein AL468_06140 ENOG4105CNI cell division protein FtsW AL468_06145 ENOG4105K6T rare lipoprotein A AL468_06150 ENOG4105DZ1 carboxypeptidase AL468_06155 ENOG4108Z43 UPF0250 protein AL468_06160 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AL468_06165 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AL468_06170 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL468_06175 ENOG4108JYZ YitT family AL468_06190 ENOG4105CG3 alpha amylase, catalytic region AL468_06195 ENOG4105C5Y PTS System AL468_06200 ENOG4105D4X repressor AL468_06205 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AL468_06210 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AL468_06215 ENOG4108UMI ABC transporter, permease AL468_06220 ENOG4105D01 (LipO)protein AL468_06225 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein AL468_06230 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AL468_06235 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AL468_06245 ENOG4105BZU Histidine kinase AL468_06250 ENOG4105EWT decarboxylase family AL468_06255 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease AL468_06260 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AL468_06265 ENOG4105M08 Membrane AL468_06275 ENOG4105ETT transcriptional Regulator, LysR family AL468_06280 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AL468_06285 ENOG4106VK6 Flagellar motor protein AL468_06290 ENOG4105E14 MotA TolQ exbB proton channel AL468_06295 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL468_06300 ENOG4105CTB Polyprenyl synthetase AL468_06305 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AL468_06310 ENOG4108ZAI phosphatidylglycerophosphatase a AL468_06315 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AL468_06320 ENOG4107YIM Involved in the transcription termination process (By similarity) AL468_06325 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AL468_06340 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL468_06345 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AL468_06350 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AL468_06355 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AL468_06360 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AL468_06365 ENOG4108DJV Fermentation respiration switch protein AL468_06370 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AL468_06380 ENOG4105C7N Xanthine uracil vitamin C permease AL468_06385 ENOG4105CIN aminoacyl-histidine dipeptidase AL468_06400 ENOG4105X58 receptor AL468_06415 ENOG4108ETH Formylglycinamide ribotide synthetase AL468_06420 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AL468_06430 ENOG4108Z6B deaminase AL468_06435 ENOG4105CFC Transporter AL468_06470 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AL468_06480 ENOG4105CK2 sodium dicarboxylate symporter AL468_06485 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AL468_06490 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AL468_06500 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AL468_06505 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL468_06510 ENOG4105VDB UPF0125 protein AL468_06515 ENOG4108Z1B Cyclase dehydrase AL468_06520 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AL468_06535 ENOG4105ETT transcriptional Regulator, LysR family AL468_06540 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AL468_06560 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL468_06565 ENOG4108IQK o-acetylhomoserine AL468_06585 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL468_06590 ENOG4105BZG amino acid carrier protein AL468_06595 ENOG4106HK8 GPR1 FUN34 yaaH family protein AL468_06605 ENOG4107S6Z Na H antiporter AL468_06685 ENOG4105DFP Integrase AL468_06690 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL468_06695 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL468_06700 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL468_06715 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AL468_06720 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL468_06725 ENOG4105N21 Membrane AL468_06730 ENOG4105CUT histidyl-tRNA synthetase AL468_06735 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AL468_06750 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AL468_06755 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AL468_06760 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AL468_06765 ENOG4105WVQ Fe-S assembly protein IscX AL468_06770 ENOG4108ZIT Ferredoxin, 2FE-2S AL468_06775 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AL468_06780 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AL468_06785 ENOG4108Z4V iron-sulfur cluster assembly AL468_06790 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AL468_06795 ENOG4105C3J Cysteine desulfurase AL468_06800 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AL468_06805 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AL468_06810 ENOG4105ECY inositol monophosphatase AL468_06815 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_06820 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_06825 ENOG4105VIE preprotein translocase, subunit YajC AL468_06830 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AL468_06835 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AL468_06850 ENOG4105W87 Cbs domain AL468_06855 ENOG4108I9X Isocitrate lyase AL468_06860 ENOG4107QP3 malate synthase g AL468_06865 ENOG4105C5Q Transcriptional regulator AL468_06870 ENOG4105D3R alkyl hydroperoxide reductase AL468_06875 ENOG4106N3A copper homeostasis protein cutc AL468_06880 ENOG4105CSR polyphosphate kinase 2 AL468_06890 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL468_06895 ENOG4105E2Z phosphate ABC transporter (Permease AL468_06900 ENOG4105C8U phosphate abc transporter AL468_06905 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AL468_06910 ENOG4105C9X ppx gppa phosphatase AL468_06920 ENOG4105BZU Histidine kinase AL468_06925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL468_06935 ENOG4105DH7 May be involved in recombination (By similarity) AL468_06940 ENOG4105CFP Peptidase U32 AL468_06945 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AL468_07005 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_07010 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AL468_07015 ENOG4105C34 Pseudouridine synthase AL468_07020 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL468_07025 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AL468_07030 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AL468_07040 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL468_07045 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) AL468_07050 ENOG4107SC1 transglycosylase AL468_07055 ENOG4105C5H ABC transporter AL468_07065 ENOG4105E4C Lytic transglycosylase catalytic AL468_07070 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AL468_07075 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL468_07080 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AL468_07085 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AL468_07090 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL468_07110 ENOG4108HRK Histidine kinase AL468_07115 ENOG4108NEV two component transcriptional regulator, LytTR family AL468_07125 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AL468_07130 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AL468_07135 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AL468_07140 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL468_07145 ENOG4105DTN riboflavin biosynthesis protein ribF AL468_07150 ENOG4105CJR Integral membrane protein (MviN AL468_07155 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AL468_07160 ENOG41080HT Transcriptional regulator, arsr family AL468_07165 ENOG41063Z6 transcriptional regulator, lysR family AL468_07180 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AL468_07185 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AL468_07190 ENOG4105HF0 Membrane AL468_07195 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AL468_07200 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AL468_07205 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) AL468_07215 ENOG4105CPC Aldo Keto reductase AL468_07225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_07230 ENOG4105CRK lysyL-tRNA synthetase AL468_07240 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AL468_07245 ENOG4105T95 Thiol disulfide interChange protein AL468_07250 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL468_07255 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AL468_07260 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL468_07265 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AL468_07270 ENOG4105C1J atp-dependent rna helicase AL468_07275 ENOG4105D1Q UPF0246 protein AL468_07280 ENOG4105BZG amino acid carrier protein AL468_07295 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AL468_07305 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AL468_07310 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) AL468_07315 ENOG4108YYH Nadph-dependent fmn reductase AL468_07320 ENOG4105D98 threonine synthase AL468_07325 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AL468_07345 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL468_07360 ENOG41065U4 response regulator AL468_07370 ENOG4105BZU Histidine kinase AL468_07380 ENOG4105N5T Radical SAM Protein AL468_07400 ENOG4105BZ8 glutamate synthase AL468_07410 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AL468_07415 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AL468_07420 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AL468_07425 ENOG4105EN6 Membrane AL468_07430 ENOG4105VP0 transcriptional regulator, lysR family AL468_07445 ENOG4105EJ9 Membrane AL468_07465 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AL468_07470 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AL468_07475 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AL468_07480 ENOG4105M6F mutator MutT protein AL468_07485 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL468_07495 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_07500 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AL468_07505 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AL468_07510 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AL468_07515 ENOG4105DFU Cell wall formation (By similarity) AL468_07520 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AL468_07530 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AL468_07535 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AL468_07540 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AL468_07545 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AL468_07550 ENOG4105CJN penicillin-binding protein AL468_07555 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL468_07560 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AL468_07570 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AL468_07580 ENOG41082RQ UPF0102 protein AL468_07585 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL468_07590 ENOG4105W4M Transport-associated protein AL468_07595 ENOG4105KB2 stringent starvation protein b AL468_07600 ENOG4107MKT Stringent starvation protein a AL468_07605 ENOG4105EIX cytochrome c1 AL468_07610 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL468_07615 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL468_07620 ENOG4108UJD 30S ribosomal protein S9 AL468_07625 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AL468_07635 ENOG4105D6Z AFG1 family ATPase AL468_07645 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AL468_07650 ENOG4105C0H protease AL468_07655 ENOG4105C0H protease AL468_07660 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_07665 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_07670 ENOG4105IPS esterase AL468_07675 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AL468_07680 ENOG4108SX3 cytoplasmic protein AL468_07685 ENOG41087AY ADP-Ribose pyrophosphatase AL468_07690 ENOG4105DFG type I secretion outer membrane protein AL468_07695 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AL468_07700 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AL468_07705 ENOG4105C8Q Methyl-accepting chemotaxis AL468_07715 ENOG4105I7R Adenylate cyclase AL468_07720 ENOG4107IX6 phosphate transport regulator AL468_07725 ENOG4105CJ3 phosphate transporter AL468_07730 ENOG4106MWK domain protein AL468_07735 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL468_07750 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AL468_07755 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AL468_07760 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL468_07765 ENOG4107ZVW dihydroneopterin aldolase AL468_07770 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AL468_07775 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AL468_07780 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL468_07785 ENOG4105VCC 30S ribosomal protein S21 AL468_07790 ENOG4105KTH gatB Yqey AL468_07795 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AL468_07800 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_07810 ENOG4105D01 (LipO)protein AL468_07845 ENOG4105CTS PTS system mannitol-specific AL468_07850 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AL468_07855 ENOG4105E61 Mannitol repressor protein AL468_07870 ENOG4108UTZ Dihydroxyacetone kinase AL468_07875 ENOG4105CMT Dihydroxyacetone kinase AL468_07885 ENOG4105GR3 Histidine kinase AL468_07900 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AL468_07905 ENOG410804X Transcriptional regulator AL468_07915 ENOG4105CA9 Pyruvate kinase AL468_07925 ENOG4105BZU Histidine kinase AL468_07930 ENOG4108ZP8 Acetolactate synthase small subunit AL468_07935 ENOG4105C7K acetolactate synthase AL468_07940 ENOG4108IQE Amp-dependent synthetase and ligase AL468_07945 ENOG41064T2 transcriptional regulator, lysR family AL468_07970 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AL468_07975 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AL468_07980 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL468_07985 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL468_07995 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AL468_08000 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AL468_08005 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AL468_08010 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AL468_08015 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AL468_08020 ENOG4105NWN ApaG protein AL468_08025 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AL468_08040 ENOG4105DWK Membrane AL468_08045 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AL468_08050 ENOG4105K46 50S ribosomal protein l27 AL468_08055 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AL468_08060 ENOG4105EAH synthase AL468_08070 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AL468_08075 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AL468_08105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_08110 ENOG4105CC0 LysR family Transcriptional regulator AL468_08115 ENOG4107T0D ABC, transporter AL468_08120 ENOG4106SMU thiamine transporter membrane protein AL468_08125 ENOG4105DP9 ABC transporter AL468_08130 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AL468_08135 ENOG4105DFU Cell wall formation (By similarity) AL468_08145 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AL468_08150 ENOG4105F0N pyrophosphate phospho-hydrolase AL468_08160 ENOG41066HZ AIG2-like family AL468_08165 ENOG4105MA0 exported protein AL468_08170 ENOG4105CFU surface antigen AL468_08175 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL468_08180 ENOG41061GZ Protein of unknown function (DUF1107) AL468_08185 ENOG4108UUE Transcriptional regulator AL468_08200 ENOG4108I0Y (ABC) transporter AL468_08220 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AL468_08230 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AL468_08235 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AL468_08240 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL468_08245 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AL468_08255 ENOG4105C1J atp-dependent rna helicase AL468_08260 ENOG4107YB6 acetyltransferase, (GNAT) family AL468_08270 ENOG4108V1T peptidylprolyl cis-trans isomerase AL468_08280 ENOG4108ZT0 50S ribosomal protein l17 AL468_08285 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL468_08290 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AL468_08295 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AL468_08300 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AL468_08310 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AL468_08315 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AL468_08320 ENOG4105VPB 50S ribosomal protein L30 AL468_08325 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AL468_08335 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AL468_08340 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AL468_08345 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AL468_08350 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AL468_08355 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AL468_08360 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AL468_08365 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AL468_08370 ENOG41083MP 50s ribosomal protein l29 AL468_08375 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AL468_08380 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AL468_08385 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AL468_08390 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AL468_08395 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AL468_08400 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AL468_08405 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AL468_08410 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AL468_08415 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AL468_08420 ENOG4105VFB Binds the 23S rRNA (By similarity) AL468_08430 ENOG4105C25 Primosomal protein n' AL468_08435 ENOG4105ETE Transcriptional regulator (LacI family AL468_08445 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AL468_08450 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AL468_08455 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AL468_08460 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL468_08465 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AL468_08475 ENOG4105CBT Fructose-1,6-bisphosphatase AL468_08505 ENOG4105CP7 Triose-phosphate isomerase AL468_08510 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AL468_08530 ENOG4108RYC glycosyltransferase AL468_08545 ENOG41090RK glycosyl transferase AL468_08565 ENOG4105ESV Glycosyl transferase, family 4 AL468_08615 ENOG4105DAY polysaccharide export protein AL468_08630 ENOG4108MDC (LipO)protein AL468_08640 ENOG4105E3R (LipO)protein AL468_08645 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AL468_08650 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AL468_08660 ENOG4105XA0 heptosyltransferase ii AL468_08665 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AL468_08670 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AL468_08710 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AL468_08715 ENOG4105C1B dTDP-glucose 4-6-dehydratase AL468_08720 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) AL468_08725 ENOG41080IJ Diacylglycerol kinase AL468_08730 ENOG4105DKP glycosyl transferase, family 9 AL468_08735 ENOG4106WTF Glycosyl transferase, family 2 AL468_08745 ENOG4108JMC lipopolysaccharide core biosynthesis protein AL468_08750 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AL468_08755 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AL468_08770 ENOG4105KDC 50s ribosomal protein l28 AL468_08775 ENOG4105W5Q DNA repair protein (RadC AL468_08780 ENOG4105C8Q Methyl-accepting chemotaxis AL468_08790 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AL468_08795 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AL468_08800 ENOG4105D1S lipid A biosynthesis AL468_08805 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AL468_08810 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AL468_08820 ENOG4105DSJ YicC domain protein AL468_08830 ENOG4105DFD Na H antiporter AL468_08835 ENOG4105CIF Ornithine Cyclodeaminase AL468_08855 ENOG4108JQ7 (ABC) transporter AL468_08865 ENOG4107QRA Extracellular solute-binding protein, family 5 AL468_08870 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AL468_08875 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AL468_08905 ENOG4109015 Biopolymer transport protein exbD tolR AL468_08920 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AL468_08925 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AL468_08930 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL468_08935 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AL468_08940 ENOG4105CB5 ATP-dependent DNA helicase recG AL468_08945 ENOG4105C2W permease AL468_08950 ENOG4105E0F Histidine kinase AL468_08955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL468_08965 ENOG4108RRZ Transcription elongation factor GreB AL468_08975 ENOG4105BZM domain protein AL468_08985 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_08990 ENOG4105MJ2 Competence protein AL468_08995 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AL468_09000 ENOG4107RK2 ADP-ribose diphosphatase NudE AL468_09010 ENOG4105PIC general secretion pathway protein N AL468_09015 ENOG4105U1E general secretion pathway protein M AL468_09020 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) AL468_09025 ENOG4108RTD type II secretion system protein K AL468_09030 ENOG4108WWZ General secretion pathway protein J AL468_09035 ENOG4105X5Z General secretion pathway protein I AL468_09040 ENOG4105VWV general secretion pathway protein h AL468_09045 ENOG4108VAU general secretion pathway protein G AL468_09050 ENOG4105D7Q type ii secretion system AL468_09055 ENOG4107QHF type ii secretion system protein e AL468_09065 ENOG4108XKW General secretion pathway protein C AL468_09070 ENOG4105VEJ Heat shock protein AL468_09075 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AL468_09080 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AL468_09090 ENOG4105SUU thioesterase domain AL468_09095 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AL468_09100 ENOG4107S2Z UPF0761 membrane protein AL468_09125 ENOG4105C5F glutamine synthetase AL468_09135 ENOG4105CUX Signal transduction histidine kinase AL468_09140 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_09145 ENOG4105BZU Histidine kinase AL468_09150 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL468_09155 ENOG4105D4P Coproporphyrinogen iii oxidase AL468_09160 ENOG4105XCT Protein of unknown function (DUF2489) AL468_09165 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AL468_09180 ENOG4106RE7 Cytochrome AL468_09185 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AL468_09190 ENOG4105C2M dna polymerase I AL468_09200 ENOG4105KD7 acetyltransferase AL468_09205 ENOG4105D52 delta-aminolevulinic acid dehydratase AL468_09215 ENOG4105F8V Hydrolase, tatD family AL468_09225 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AL468_09230 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AL468_09235 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AL468_09240 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL468_09245 ENOG4105JC1 sterol-binding domain protein AL468_09250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AL468_09255 ENOG4105CGY Dna recombination protein AL468_09265 ENOG4105BZU Histidine kinase AL468_09270 ENOG4105DSF transport protein AL468_09305 ENOG4107TE5 Lipid kinase AL468_09330 ENOG4108JUA Transcriptional regulator AL468_09335 ENOG4105CBX hi0933 family AL468_09340 ENOG4108V6B universal stress protein B AL468_09345 ENOG41090A1 ferritin AL468_09350 ENOG4108M6U Universal stress protein A AL468_09355 ENOG4105EMK carboxylate amino acid amine transporter AL468_09365 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AL468_09370 ENOG4105BZU Histidine kinase AL468_09375 ENOG4108VVK transcriptional Regulator, AsnC AL468_09380 ENOG4105DGW oligopeptidase A AL468_09385 ENOG4105D6S protein involved in catabolism of external DNA AL468_09390 ENOG4105DC8 reductase AL468_09395 ENOG4107RSM transcriptional regulator AL468_09400 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AL468_09405 ENOG4108UHU Aldolase AL468_09410 ENOG4105C6Z Gluconate AL468_09415 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AL468_09420 ENOG4105C01 Dihydroxy-acid dehydratase AL468_09430 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AL468_09435 ENOG41064T2 transcriptional regulator, lysR family AL468_09440 ENOG4105DIQ Transcriptional regulator AL468_09480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_09485 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL468_09495 ENOG4108JQ6 ABC transporter AL468_09535 ENOG4105MPD Cytochrome AL468_09540 ENOG4105C4R Atp-dependent dna helicase AL468_09545 ENOG41067SE Tetr family transcriptional regulator AL468_09550 ENOG410624X efflux transporter, rnd family, mfp subunit AL468_09555 ENOG4105BZS acriflavin resistance protein AL468_09560 ENOG4105W0Z cytoplasmic protein AL468_09565 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AL468_09570 ENOG4105EMY transcriptional regulator AL468_09610 ENOG4108Z0R Transferase AL468_09615 ENOG4105SG3 Protein of unknown function (DUF1488) AL468_09620 ENOG4105E2X shikimate dehydrogenase AL468_09625 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AL468_09630 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL468_09635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AL468_09640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AL468_09645 ENOG4108WI1 Dna topoisomerase AL468_09650 ENOG4108RPN Protein smg homolog AL468_09655 ENOG4105C79 DNA protecting protein DprA AL468_09665 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL468_09670 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AL468_09675 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL468_09680 ENOG4105C1A potassium transporter peripheral membrane AL468_09685 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL468_09695 ENOG4108UT2 hemolysin iii AL468_09700 ENOG4108N23 SpoOM-related protein AL468_09710 ENOG4105PC1 Conserved Protein AL468_09720 ENOG4105E27 serine threonine protein kinase AL468_09725 ENOG4108Z33 Thiol disulfide Interchange Protein AL468_09730 ENOG4106HNH Acyl-transferase AL468_09740 ENOG4105C0P Mg chelatase subunit ChlI AL468_09750 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AL468_09755 ENOG4105CM2 brancheD-chain amino acid aminotransferase AL468_09760 ENOG4105C01 Dihydroxy-acid dehydratase AL468_09765 ENOG4105C7B Threonine dehydratase AL468_09770 ENOG4105F52 Transcriptional regulator AL468_09775 ENOG4105CZQ inner membrane transport protein YdhC AL468_09780 ENOG4105F87 Dehydratase AL468_09785 ENOG4105EAD ABC transporter AL468_09790 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AL468_09795 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AL468_09800 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AL468_09805 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AL468_09810 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AL468_09815 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL468_09825 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL468_09830 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AL468_09835 ENOG410684E atp synthase AL468_09840 ENOG4105FA0 parb-like partition protein AL468_09845 ENOG4107QJE Chromosome Partitioning Protein AL468_09850 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AL468_09855 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AL468_09860 ENOG4105QTB Flavodoxin AL468_09865 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AL468_09870 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AL468_09875 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AL468_09880 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AL468_09890 ENOG4105CDA abc transporter atp-binding protein AL468_09895 ENOG4105E5Q amino acid AbC transporter AL468_09900 ENOG4105EAB amino acid AbC transporter AL468_09910 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL468_09915 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AL468_09920 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AL468_09925 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_09940 ENOG4108ZNX Heat shock protein AL468_09945 ENOG4105JKW Valine--pyruvate aminotransferase AL468_09950 ENOG4107T9C Alpha amylase catalytic region AL468_09955 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AL468_09960 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AL468_09975 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AL468_09990 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AL468_09995 ENOG4105CHU acetyl-coa acetyltransferase AL468_10000 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL468_10005 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AL468_10010 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL468_10015 ENOG4108RR8 protoporphyrinogen oxidase AL468_10065 ENOG4105E3B Multicopper oxidase AL468_10070 ENOG4105WMR Protein CrcB homolog AL468_10075 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AL468_10085 ENOG4105D06 uba thif-type nad fad binding protein AL468_10095 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AL468_10100 ENOG4105D41 biosynthesis protein thiH AL468_10105 ENOG4105DC7 peptidase M24 AL468_10105 ENOG4105DC7 peptidase M24 AL468_10135 ENOG4105E18 UPF0276 protein AL468_10145 ENOG4105C4R Atp-dependent dna helicase AL468_10155 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL468_10170 ENOG4105FR1 rard protein AL468_10175 ENOG4105C9U ATP-dependent DNA helicase RecQ AL468_10185 ENOG4105EX9 Membrane AL468_10190 ENOG4105C9X ppx gppa phosphatase AL468_10195 ENOG4105C1J atp-dependent rna helicase AL468_10200 ENOG4105K63 Thioredoxin AL468_10205 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AL468_10220 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AL468_10230 ENOG4107QK7 reductase AL468_10270 ENOG410601J HemY protein AL468_10275 ENOG4105ECF c-methyltransferase AL468_10280 ENOG41076E6 Uroporphyrinogen-III Synthase AL468_10285 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AL468_10290 ENOG4107T0K Adenylate cyclase AL468_10295 ENOG4105XQ6 frataxin-like protein AL468_10305 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL468_10310 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AL468_10320 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL468_10325 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AL468_10330 ENOG4105BZU Histidine kinase AL468_10335 ENOG4106IUH DTW domain containing protein AL468_10350 ENOG4105DQF Hydrolase AL468_10355 ENOG4108EUD Lysophospholipase AL468_10360 ENOG410829K Lysine exporter protein (Lyse ygga) AL468_10365 ENOG4105D58 Diguanylate phosphodiesterase AL468_10370 ENOG41082YX Transcriptional regulator, arsr family AL468_10375 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL468_10425 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AL468_10435 ENOG4106H78 methyltransferase AL468_10440 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AL468_10445 ENOG4105CAK Cell division ATP-binding protein ftsE AL468_10450 ENOG4105CRP Part of the ABC transporter FtsEX involved in AL468_10455 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_10465 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL468_10470 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AL468_10475 ENOG4105X6C Flagellar basal body-associated protein FliL AL468_10480 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AL468_10485 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AL468_10490 ENOG4105E55 glycerol-3-phosphate acyltransferase AL468_10500 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AL468_10515 ENOG4107R73 Mate efflux family protein AL468_10520 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AL468_10535 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AL468_10540 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AL468_10550 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AL468_10585 ENOG4105JIM Phosphatidylserine synthase AL468_10595 ENOG4105D4A Cell wall formation (By similarity) AL468_10600 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AL468_10605 ENOG4105CS9 pantothenic acid kinase AL468_10635 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL468_10645 ENOG4105PM1 preprotein translocase subunit SecE AL468_10650 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AL468_10655 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AL468_10660 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AL468_10665 ENOG4108VZM 50s ribosomal protein L10 AL468_10670 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AL468_10675 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL468_10680 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL468_10685 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor AL468_10690 ENOG4105E09 nadh pyrophosphatase AL468_10695 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AL468_10700 ENOG4108RG0 uracil-dna glycosylase AL468_10705 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AL468_10710 ENOG4105R2J Conserved Protein AL468_10730 ENOG4105C12 Phosphoribosylglycinamide synthetase AL468_10740 ENOG4105DC1 bifunctional purine biosynthesis protein purh AL468_10750 ENOG4105W1Y Transcriptional regulator AL468_10755 ENOG4108M3R transcriptional activator CadC AL468_10765 ENOG4105D5Q Arginine ornithine antiporter AL468_10770 ENOG4105CXN decarboxylase AL468_10825 ENOG4105C5H ABC transporter AL468_10835 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AL468_10840 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL468_10845 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AL468_10855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AL468_10860 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AL468_10865 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AL468_10870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_10885 ENOG4105D8G Major Facilitator superfamily AL468_10890 ENOG4105BZU Histidine kinase AL468_10895 ENOG4105C9Q fumarate hydratase class II AL468_10910 ENOG4107QN1 sodium solute AL468_10920 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AL468_10930 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL468_10935 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL468_10940 ENOG4108IJ0 Aspartate ammonia-lyase AL468_10945 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 AL468_10950 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AL468_10960 ENOG4105E0F Histidine kinase AL468_10965 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL468_10970 ENOG4108SPG Periplasmic Protein AL468_10975 ENOG41076HS cation diffusion facilitator family transporter AL468_10980 ENOG4105CTQ phosphohexokinase AL468_10985 ENOG4107QI1 Mate efflux family protein AL468_10990 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL468_10995 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL468_11005 ENOG4105KT7 mgtC SapB transporter AL468_11010 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AL468_11015 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AL468_11025 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL468_11030 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL468_11035 ENOG4105E33 succinate dehydrogenase AL468_11045 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AL468_11055 ENOG41062JF Transcriptional regulator AL468_11065 ENOG41063SB peptidase AL468_11070 ENOG4105D7W serine acetyltransferase AL468_11075 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AL468_11080 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AL468_11085 ENOG4107YZP Rhodanese domain protein AL468_11090 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AL468_11100 ENOG4105C8P )-transporter AL468_11105 ENOG4105DJ4 phosphatidylserine decarboxylase AL468_11110 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL468_11115 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AL468_11180 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AL468_11190 ENOG4105K8N protein family UPF0079, ATPase AL468_11195 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AL468_11200 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AL468_11205 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AL468_11210 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AL468_11215 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AL468_11220 ENOG4107QJR hflk protein AL468_11225 ENOG4105EPW hflc protein AL468_11235 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL468_11245 ENOG4108UV7 flagellar protein motX AL468_11250 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL468_11255 ENOG4105KPV Transcriptional regulator AL468_11260 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AL468_11265 ENOG4105C2N RNA methyltransferase TrmH family group 3 AL468_11270 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL468_11275 ENOG4105C31 Tryptophanyl-tRNA synthetase AL468_11290 ENOG4105DDQ anthranilate synthase AL468_11295 ENOG4105C8Y Acetylornithine aminotransferase AL468_11305 ENOG4105C26 Dehydrogenase AL468_11315 ENOG4107RYR Transcriptional regulator, Crp Fnr family AL468_11320 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AL468_11325 ENOG4105YP7 UPF0270 protein AL468_11330 ENOG4105DNZ Alpha Beta Hydrolase AL468_11340 ENOG4105C5H ABC transporter AL468_11345 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL468_11360 ENOG4108YZY peptidylprolyl cis-trans isomerase AL468_11365 ENOG4105D44 asparaginase AL468_11370 ENOG41069P5 Protein slyX homolog AL468_11380 ENOG4108V1T peptidylprolyl cis-trans isomerase AL468_11385 ENOG4105WWK YheO domain protein AL468_11390 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AL468_11395 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AL468_11400 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AL468_11405 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AL468_11410 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AL468_11415 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL468_11420 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL468_11425 ENOG4105W53 bacterioferritin-associated ferredoxin AL468_11430 ENOG4108UQY Iron-storage protein AL468_11435 ENOG4105C6K Malic enzyme AL468_11440 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AL468_11445 ENOG4105C28 cystathionine AL468_11450 ENOG4105CFH Aspartokinase AL468_11455 ENOG4105SYT Methylenetetrahydrofolate reductase AL468_11465 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AL468_11470 ENOG4105CWC Acetylornithine deacetylase AL468_11475 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AL468_11480 ENOG4105CAS nag kinase AL468_11485 ENOG4105CDH Citrulline--aspartate ligase AL468_11490 ENOG4105CH7 arginosuccinase AL468_11505 ENOG4107QN2 dihydrolipoyl dehydrogenase AL468_11510 ENOG4105EHV domain protein AL468_11525 ENOG4108JQC penicillin-binding protein 1A AL468_11550 ENOG4105E4G Type IV pilus AL468_11555 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AL468_11560 ENOG4105D49 3-dehydroquinate synthase AL468_11570 ENOG4105DFE Dna adenine methylase AL468_11575 ENOG4105DJV ribulose-phosphate 3-epimerase AL468_11580 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AL468_11585 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) AL468_11590 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AL468_11595 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AL468_11605 ENOG4105CDU Replicative dna helicase AL468_11610 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL468_11615 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AL468_11620 ENOG4107QP8 phosphohexose isomerase AL468_11630 ENOG4105MYN Zinc uptake regulation protein AL468_11635 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL468_11655 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AL468_11660 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AL468_11665 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AL468_11725 ENOG4105EEQ Na H antiporter AL468_11730 ENOG4105C3R Methionine synthase AL468_11735 ENOG4105CFH Aspartokinase AL468_11745 ENOG4105C5R Aminotransferase AL468_11755 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AL468_11760 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AL468_11765 ENOG41086KC Transcriptional regulator AL468_11770 ENOG4108UUM single-stranded DNA-binding protein AL468_11800 ENOG4107QYX exodeoxyribonuclease v alpha AL468_11825 ENOG41062P1 Diguanylate cyclase phosphodiesterase AL468_11860 ENOG4107QHF type ii secretion system protein e AL468_11865 ENOG4105D7Q type ii secretion system AL468_11910 ENOG4105DFF Rod shape-determining protein mreb AL468_11915 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AL468_11920 ENOG4105VQ7 Rod shape-determining protein MreD AL468_11925 ENOG4108Z03 MAF-like protein AL468_11930 ENOG4105C03 ribonuclease AL468_11935 ENOG4105QD6 exported protein AL468_11945 ENOG4105D1U peptidase U62 modulator of DNA gyrase AL468_11950 ENOG4108IAB Phoh family AL468_11955 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AL468_11960 ENOG4105K3M )-transporter AL468_11965 ENOG4105D3G Pseudouridine synthase AL468_11970 ENOG4105C5I Dehydrogenase AL468_11975 ENOG4105N42 UPF0307 protein AL468_11980 ENOG4105CMS peptidase U62, modulator of DNA gyrase AL468_11985 ENOG4105CJW magnesium transporter AL468_11990 ENOG41080Z8 PHOSPHOCARRIER protein AL468_11995 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AL468_12000 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AL468_12005 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AL468_12010 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_12015 ENOG4108IUZ ABC transporter AL468_12020 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AL468_12030 ENOG4105C2X Arabinose 5-phosphate isomerase AL468_12040 ENOG4105DHJ ABC, transporter AL468_12045 ENOG4105CY3 ABC transporter, permease AL468_12050 ENOG4107PE3 Mammalian cell entry related domain protein AL468_12055 ENOG4105E3I toluene tolerance AL468_12065 ENOG4105VFK BolA family AL468_12070 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AL468_12075 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AL468_12080 ENOG4105KME endoribonuclease L-psp AL468_12085 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AL468_12090 ENOG4105CXT aspartate transcarbamylase AL468_12100 ENOG4105DBV ornithine carbamoyltransferase AL468_12105 ENOG4105CEU Arginine dihydrolase AL468_12120 ENOG4108MJ3 acetyltransferase AL468_12130 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AL468_12135 ENOG4105MYG DNA polymerase iii, chi subunit AL468_12145 ENOG4108M8S permease YjgP YjgQ family protein AL468_12150 ENOG4108K5H permease YjgP YjgQ family protein AL468_12160 ENOG4105EXU Membrane AL468_12165 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL468_12185 ENOG4105CK1 PTS System AL468_12190 ENOG4105VCP PTS System AL468_12195 ENOG4105F8D glycoside hydrolase family 4 AL468_12200 ENOG410901P UPF0249 protein AL468_12210 ENOG4108ESY Metal dependent phosphohydrolase AL468_12255 ENOG4105C26 Dehydrogenase AL468_12285 ENOG4105C8Q Methyl-accepting chemotaxis AL468_12330 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AL468_12335 ENOG4105CEN a g-specific adenine glycosylase AL468_12340 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AL468_12350 ENOG4105CSV Glutaminase AL468_12355 ENOG4105CSA Coproporphyrinogen iii oxidase AL468_12360 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL468_12370 ENOG4105VZ9 UPF0235 protein AL468_12375 ENOG4108VIA integral membrane protein AL468_12380 ENOG4105II7 pyrroline-5-carboxylate reductase AL468_12385 ENOG4105DFA alanine racemase domain protein AL468_12390 ENOG4105CZX twitching motility protein AL468_12395 ENOG4105CZX twitching motility protein AL468_12400 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AL468_12405 ENOG4108UJU UPF0301 protein AL468_12410 ENOG4105D7Z glutathione synthase AL468_12415 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AL468_12420 ENOG4105RWS endonuclease I AL468_12425 ENOG4105GPY SprT protein AL468_12435 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AL468_12445 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL468_12450 ENOG4108R4R Iron-regulated virulence regulatory protein AL468_12455 ENOG4105D05 Receptor AL468_12460 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL468_12465 ENOG4105BZA Phosphoglycerate kinase AL468_12470 ENOG4105D2N Aldolase AL468_12475 ENOG4105D64 Mechanosensitive ion channel AL468_12490 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AL468_12495 ENOG4105MPN Membrane AL468_12500 ENOG4108JQ1 Dehydrogenase AL468_12505 ENOG4105E66 phosphoriboisomerase A AL468_12510 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AL468_12520 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AL468_12535 ENOG4105D0A hydroxylase AL468_12540 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL468_12555 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AL468_12560 ENOG4105Y75 tpr repeat protein AL468_12570 ENOG4108IYU L-aspartate oxidase AL468_12580 ENOG4105EMN RNA polymerase sigma factor AL468_12600 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AL468_12605 ENOG4105C3F Signal peptidase i AL468_12610 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AL468_12615 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AL468_12620 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AL468_12625 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AL468_12630 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AL468_12635 ENOG4105BZU Histidine kinase AL468_12645 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AL468_12655 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL468_12660 ENOG4105DXN mazG family AL468_12665 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AL468_12670 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AL468_12675 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL468_12680 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AL468_12685 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AL468_12690 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AL468_12695 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AL468_12700 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AL468_12710 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_12715 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AL468_12720 ENOG4107TH8 cina domain protein AL468_12725 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AL468_12730 ENOG4105Y3E Modulates RecA activity (By similarity) AL468_12735 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL468_12740 ENOG4105CFH Aspartokinase AL468_12745 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AL468_12810 ENOG4107QSA Oxaloacetate decarboxylase AL468_12815 ENOG4105D9Q decarboxylase (Beta subunit) AL468_12825 ENOG4105W39 Membrane AL468_12835 ENOG4105D9M gamma-glutamylcysteine synthetase AL468_12850 ENOG4108JU6 CBS domain protein AL468_12855 ENOG4106KVJ cytochrome C assembly protein AL468_12860 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AL468_12865 ENOG4105K5M 30s ribosomal protein S16 AL468_12870 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AL468_12875 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AL468_12880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AL468_12885 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AL468_12890 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AL468_12895 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AL468_12900 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AL468_12905 ENOG4105D7Q type ii secretion system AL468_12910 ENOG4107QHF type ii secretion system protein e AL468_12915 ENOG4108ZUW Major pilin subunit AL468_12925 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AL468_12935 ENOG41073TP transcriptional regulator AL468_12940 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AL468_12945 ENOG4107QSN dihydrolipoamide acetyltransferase AL468_12950 ENOG4107QN2 dihydrolipoyl dehydrogenase AL468_12955 ENOG410630P Transcriptional regulator AL468_12960 ENOG4108UGV hypoxanthine phosphoribosyltransferase AL468_12965 ENOG41077A9 carbonic anhydrase AL468_12970 ENOG4105CHH sulfate transporter AL468_12975 ENOG4105DA5 (ABC) transporter AL468_12980 ENOG4105E3A (ABC) transporter AL468_12990 ENOG4105D1S lipid A biosynthesis AL468_12995 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AL468_13000 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AL468_13005 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL468_13010 ENOG4105DJ0 Poly(A) Polymerase AL468_13015 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AL468_13020 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AL468_13025 ENOG4105PW4 Sugar fermentation stimulation protein homolog AL468_13030 ENOG4105CQ7 ATP-dependent helicase AL468_13035 ENOG4105BZ4 penicillin-binding protein AL468_13040 ENOG4105D78 K07001 NTE family protein AL468_13045 ENOG4107QIJ Aconitate hydratase 2 AL468_13050 ENOG4105XTV UPF0231 protein AL468_13055 ENOG4108YZA Nitrogen regulatory protein pii AL468_13075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_13090 ENOG4105E2D ec 3.2.1.52 AL468_13095 ENOG4105RD7 BadF BadG BcrA BcrD AL468_13105 ENOG4108JQ7 (ABC) transporter AL468_13110 ENOG4105C3U ABC transporter AL468_13115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_13125 ENOG4107QRA Extracellular solute-binding protein, family 5 AL468_13130 ENOG4105BZU Histidine kinase AL468_13135 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL468_13140 ENOG4105F4G Membrane AL468_13145 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AL468_13150 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AL468_13165 ENOG4105DR5 peptidase AL468_13170 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL468_13180 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AL468_13185 ENOG4107QE9 Inherit from COG: Membrane AL468_13190 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL468_13195 ENOG4105HBR Rna-binding protein AL468_13200 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AL468_13205 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AL468_13210 ENOG4105EEI dihydropteroate synthase AL468_13215 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AL468_13240 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AL468_13245 ENOG4105CHV Transcription elongation factor NusA AL468_13250 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AL468_13255 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AL468_13260 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AL468_13265 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AL468_13270 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AL468_13285 ENOG4105C3S Mate efflux family protein AL468_13290 ENOG4106RZ4 Peptidase U32 AL468_13295 ENOG4105CFP Peptidase U32 AL468_13300 ENOG4105BZU Histidine kinase AL468_13310 ENOG4105XPQ lipid carrier protein AL468_13315 ENOG4108YYD acetyltransferase AL468_13335 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AL468_13345 ENOG4105EYA deoxyribonuclease AL468_13350 ENOG4105D9N nucleoside AL468_13360 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AL468_13365 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AL468_13370 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AL468_13375 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL468_13385 ENOG4105EAC phosphoserine phosphatase AL468_13395 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AL468_13400 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL468_13405 ENOG4105ETT transcriptional Regulator, LysR family AL468_13415 ENOG4108IQE Amp-dependent synthetase and ligase AL468_13505 ENOG41064T2 transcriptional regulator, lysR family AL468_13510 ENOG4105E5D amino acid AL468_13515 ENOG4105FK9 beta-D-galactosidase beta subunit AL468_13520 ENOG4105CNT hydrolase family 2 AL468_13525 ENOG4105CQ4 Transcriptional regulator AL468_13535 ENOG4105CMR udp-glucose 4-epimerase AL468_13540 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AL468_13545 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AL468_13550 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AL468_13565 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AL468_13570 ENOG41060NJ transcriptional regulator AL468_13575 ENOG4108Y51 tRNA-binding protein AL468_13600 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AL468_13605 ENOG4105E98 transcriptional regulator DeoR family AL468_13610 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AL468_13615 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL468_13625 ENOG4105CXY transporter AL468_13630 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AL468_13635 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AL468_13640 ENOG4105X2V dna damage-inducible protein AL468_13645 ENOG4105EVZ LysR family transcriptional regulator AL468_13655 ENOG4105E68 Sulfatase AL468_13660 ENOG4105DSY exodeoxyribonuclease V, gamma AL468_13670 ENOG4107QKA exodeoxyribonuclease V beta AL468_13675 ENOG4107QYX exodeoxyribonuclease v alpha AL468_13700 ENOG4107QZM n-acetylglutamate synthase AL468_13715 ENOG4105CA3 membrane-bound lytic murein transglycosylase AL468_13720 ENOG4105CUZ uba thif-type nad fad binding protein AL468_13725 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AL468_13730 ENOG4105BZU Histidine kinase AL468_13735 ENOG4105C9B Cysteine desulfurase AL468_13740 ENOG4107S0N DJ-1 family AL468_13745 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AL468_13770 ENOG4105K6V RNA polymerase AL468_13785 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL468_13790 ENOG4105IEY (LipO)protein AL468_13795 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL468_13800 ENOG4105M85 Bola protein AL468_13810 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_13815 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_13820 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_13825 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_13830 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_13835 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AL468_13840 ENOG4105CJ2 (LipO)protein AL468_13855 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AL468_13860 ENOG4105C9U ATP-dependent DNA helicase RecQ AL468_13865 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL468_13880 ENOG4105C8J )-transporter AL468_13890 ENOG4105W1I UPF0253 protein AL468_13900 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AL468_13905 ENOG4108R96 Methyltransferase, YaeB family AL468_13910 ENOG4105NRA 50s ribosomal protein l31 type b AL468_13920 ENOG4105CFC Transporter AL468_13945 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AL468_13950 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL468_13955 ENOG4108UPT UPF0178 protein AL468_13980 ENOG4105DR9 pseudouridine synthase AL468_13985 ENOG4105DR9 pseudouridine synthase AL468_13990 ENOG4108T8E UPF0325 protein AL468_13995 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AL468_14000 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AL468_14005 ENOG4105CE9 30S ribosomal protein S2 AL468_14010 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AL468_14015 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AL468_14020 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AL468_14025 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AL468_14030 ENOG4105KNE Phosphatidate cytidylyltransferase AL468_14035 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AL468_14040 ENOG4105DZP Membrane-associated zinc metalloprotease AL468_14045 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL468_14050 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AL468_14055 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_14060 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL468_14065 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_14070 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_14075 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL468_14080 ENOG4105C0B DNA polymerase III (alpha subunit) AL468_14085 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AL468_14090 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AL468_14095 ENOG4105N7H Cytochrome AL468_14100 ENOG4108YZA Nitrogen regulatory protein pii AL468_14105 ENOG4107NA1 Endonuclease Exonuclease phosphatase AL468_14115 ENOG4105E9H Lytic Murein transglycosylase AL468_14120 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AL468_14125 ENOG4105D1A Methyltransferase AL468_14130 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL468_14135 ENOG4108JDX DNA polymerase iii, epsilon subunit AL468_14165 ENOG4107QPN acyl-Coa dehydrogenase AL468_14170 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL468_14175 ENOG4105E7A Glutamine amidotransferase AL468_14180 ENOG4108V3E phosphoribosylglycinamide formyltransferase AL468_14185 ENOG4105CXB phosphoribosylaminoimidazole synthetase AL468_14190 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AL468_14195 ENOG4105C2W permease AL468_14215 ENOG4105ERG peptidase m48, ste24p AL468_14230 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL468_14245 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL468_14260 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL468_14265 ENOG4105KUZ arsenate reductase AL468_14285 ENOG4105QZU Inner membrane protein YfeZ AL468_14290 ENOG4105EZR dyp-type peroxidase family protein AL468_14295 ENOG4105I03 Flagellin AL468_14305 ENOG4105I03 Flagellin AL468_14310 ENOG4105I03 Flagellin AL468_14315 ENOG41063QE flagellar protein FlaG AL468_14320 ENOG4107BRV flagellar capping protein AL468_14330 ENOG4105MQ3 flagellar protein FliS AL468_14335 ENOG4108JUA Transcriptional regulator AL468_14340 ENOG4105BZU Histidine kinase AL468_14345 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_14350 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AL468_14355 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL468_14360 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL468_14370 ENOG4108JIR Flagellum-specific ATP synthase AL468_14390 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL468_14395 ENOG4105DD5 Flagellar motor switch protein AL468_14400 ENOG4105VTB flagellar biosynthesis protein fliO AL468_14405 ENOG4105CN7 Flagellar biosynthetic protein FliP AL468_14410 ENOG4105VS8 Flagellar biosynthetic protein fliq AL468_14415 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL468_14420 ENOG4105D00 flagellar biosynthetic protein flhB AL468_14425 ENOG4105D7B Flagellar biosynthesis protein flha AL468_14430 ENOG4105FZW flagellar biosynthesis regulator FlhF AL468_14435 ENOG4107R21 site-determining protein AL468_14440 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_14445 ENOG4108VYJ response regulator receiver protein AL468_14450 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AL468_14455 ENOG4105CBS Chea signal transduction histidine kinase AL468_14460 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AL468_14465 ENOG4107QJE Chromosome Partitioning Protein AL468_14475 ENOG4108V3W Chemotaxis protein, CheW AL468_14485 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AL468_14490 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AL468_14495 ENOG41060IM Heme exporter protein AL468_14500 ENOG4105X3C heme exporter protein AL468_14505 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AL468_14510 ENOG4105DA4 cytochrome c-type biogenesis protein AL468_14515 ENOG4107QX9 Thiol disulfide interChange protein AL468_14520 ENOG4108M1T Cytochrome c-type biogenesis protein AL468_14525 ENOG4105KWW Biogenesis protein AL468_14530 ENOG410903C (LipO)protein AL468_14535 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_14540 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_14555 ENOG4105CHU acetyl-coa acetyltransferase AL468_14560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL468_14570 ENOG4107QXK peptidase AL468_14575 ENOG4108BY2 phosphohistidine phosphatase AL468_14580 ENOG4108DG9 Smr protein MutS2 AL468_14585 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AL468_14590 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AL468_14595 ENOG4105EN6 Membrane AL468_14605 ENOG4108BPE -transporting atpase AL468_14610 ENOG4105MH2 YfcL protein AL468_14620 ENOG4105Q8W reductase AL468_14625 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AL468_14630 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_14640 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AL468_14645 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL468_14655 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AL468_14665 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AL468_14670 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AL468_14675 ENOG4108S3P Sporulation domain protein AL468_14680 ENOG4105E96 Colicin v production protein AL468_14685 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AL468_14690 ENOG4105EJC lysr family transcriptional regulator AL468_14695 ENOG4105I93 response regulator AL468_14705 ENOG4105WD1 Membrane AL468_14710 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AL468_14715 ENOG4107QMP dna polymerase iii subunits gamma and tau AL468_14720 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AL468_14725 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AL468_14730 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL468_14735 ENOG4105C44 Serine transporter AL468_14740 ENOG4105KME endoribonuclease L-psp AL468_14745 ENOG4105CEM UPF0597 protein AL468_14755 ENOG4105KRS Proteinase inhibitor AL468_14760 ENOG4105Y3U Transglycosylase-associated protein AL468_14765 ENOG4108ZZ3 UPF0260 protein AL468_14775 ENOG41067V3 Antibiotic biosynthesis monooxygenase AL468_14780 ENOG4108UYE Lactoylglutathione lyase AL468_14790 ENOG4105G6Z alkaline phosphatase AL468_14810 ENOG4105DHI Methyltransferase AL468_14815 ENOG4107SDU Methyl-accepting chemotaxis AL468_14820 ENOG4105DSB aldose 1-epimerase AL468_14825 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL468_14830 ENOG4105E0X reductase AL468_14840 ENOG4105VUT cytoplasmic protein AL468_14845 ENOG4105HDK L-asparaginase AL468_14850 ENOG4105D07 Signal peptide peptidase, SppA AL468_14855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_14865 ENOG41069NU Nitroreductase AL468_14870 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL468_14880 ENOG4108RU0 short-chain dehydrogenase reductase AL468_14885 ENOG4105DGU Histone deacetylase AL468_14895 ENOG4105E68 Sulfatase AL468_14900 ENOG4105YDX UPF0352 protein AL468_14905 ENOG4106V8H Nucleoid-associated protein AL468_14920 ENOG4105DFD Na H antiporter AL468_14925 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL468_14930 ENOG4105EYW Ion transport protein AL468_14935 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AL468_14940 ENOG4108EKI Dehydrogenase AL468_14955 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL468_14960 ENOG4105M2J Glutaredoxin AL468_14965 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL468_15060 ENOG4105ED4 portal protein AL468_15195 ENOG4105D3Y Na H antiporter AL468_15200 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AL468_15210 ENOG4105EIY sodium-type flagellar protein motY AL468_15215 ENOG4106WH9 Protein of unknown function (DUF2753) AL468_15220 ENOG4108UYE Lactoylglutathione lyase AL468_15225 ENOG4105CSM endonuclease III AL468_15230 ENOG4105DZB Electron transport complex AL468_15235 ENOG4108UQQ Electron transport complex AL468_15240 ENOG4105D6A Electron transport complex AL468_15250 ENOG4108R3D Electron transport complex AL468_15255 ENOG4105DGN Electron transport complex AL468_15270 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AL468_15275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_15285 ENOG4105CHW UPF0052 protein AL468_15290 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL468_15295 ENOG4108RIR Molybdenum cofactor biosynthesis protein AL468_15300 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL468_15305 ENOG4105M00 molybdopterin converting factor, subunit 1 AL468_15310 ENOG4108ZAF Molybdopterin AL468_15315 ENOG4107QSI ABC, transporter AL468_15320 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL468_15325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_15330 ENOG4105C3U ABC transporter AL468_15335 ENOG4108JQ7 (ABC) transporter AL468_15340 ENOG4105CHF Glutathione S-transferase AL468_15350 ENOG4107PU6 Membrane AL468_15355 ENOG4108DNC Involved in acetate metabolism (By similarity) AL468_15360 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL468_15365 ENOG4105PQ6 UPF0208 membrane protein AL468_15375 ENOG4105C7J ABC transporter, permease AL468_15380 ENOG4108JJB ABC transporter AL468_15385 ENOG4107R28 alpha amylase, catalytic region AL468_15390 ENOG4105BZU Histidine kinase AL468_15395 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AL468_15400 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL468_15405 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AL468_15415 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AL468_15425 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AL468_15430 ENOG4105D1F ATP-binding protein AL468_15435 ENOG4105DBI uridine monophosphokinase AL468_15445 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AL468_15450 ENOG4105KJF protein tyrosine phosphatase AL468_15455 ENOG4105CHH sulfate transporter AL468_15465 ENOG4105C03 ribonuclease AL468_15470 ENOG4105EI2 Pseudouridine synthase AL468_15475 ENOG4108UHJ MAF-like protein AL468_15480 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AL468_15485 ENOG4105VGS 50s ribosomal protein l32 AL468_15490 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AL468_15495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL468_15500 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AL468_15505 ENOG4105CHR reductase AL468_15510 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL468_15515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_15525 ENOG4105HHA aminodeoxychorismate lyase AL468_15530 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AL468_15535 ENOG4107QRG dna polymerase iii AL468_15540 ENOG4105F8V Hydrolase, tatD family AL468_15545 ENOG4105CI1 PTS System AL468_15555 ENOG4105C8J )-transporter AL468_15570 ENOG4108NRW Phospholipase, patatin family AL468_15575 ENOG4105CA9 Pyruvate kinase AL468_15580 ENOG4105DAG ROK family AL468_15585 ENOG4107R88 Chemotaxis protein (CheV) AL468_15590 ENOG4105C0B DNA polymerase III (alpha subunit) AL468_15605 ENOG4105UBK short-chain dehydrogenase reductase AL468_15610 ENOG4105ERU peptidase AL468_15615 ENOG4105CAT Cytidine monophosphate kinase AL468_15620 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AL468_15625 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL468_15630 ENOG4105Q4A inner membrane protein yciS AL468_15635 ENOG4105CFV Tetratricopeptide repeat protein AL468_15640 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AL468_15645 ENOG4108J59 Extracellular solute-binding protein, family 5 AL468_15660 ENOG4105DY2 Paraquat-inducible protein b AL468_15665 ENOG4105F1S paraquat-inducible protein a AL468_15670 ENOG4105NQN cytochrome C AL468_15680 ENOG4105DB1 molybdopterin oxidoreductase AL468_15685 ENOG4106WHD Tetrathionate reductase AL468_15690 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL468_15695 ENOG4106AFQ Histidine kinase AL468_15700 ENOG4108ZXC Two component transcriptional regulator, luxr family AL468_15710 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL468_15715 ENOG4105N6Y Thioredoxin AL468_15730 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AL468_15745 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL468_15755 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL468_15765 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL468_15785 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL468_15795 ENOG4105J12 Multidrug resistance protein mdtN AL468_15800 ENOG4105JQN Transcriptional regulator AL468_15820 ENOG41062D9 Histidine kinase AL468_15825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL468_15835 ENOG4105C8Q Methyl-accepting chemotaxis AL468_15850 ENOG4105CCT upf0313 protein AL468_15870 ENOG4105DZ2 Transcriptional regulator AL468_15875 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL468_15885 ENOG4105K9H YciI-like protein AL468_15890 ENOG4105NAU thioesterase Superfamily protein AL468_15895 ENOG4107835 probably involved in intracellular septation (By similarity) AL468_15905 ENOG4105BZU Histidine kinase AL468_15915 ENOG4105CK2 sodium dicarboxylate symporter AL468_15925 ENOG4105CEY Amp-dependent synthetase and ligase AL468_15930 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL468_15935 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AL468_15940 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL468_15945 ENOG4105DK0 Indole-3-glycerol phosphate synthase AL468_15950 ENOG4108I0Q anthranilate phosphoribosyltransferase AL468_15955 ENOG4105DDQ anthranilate synthase AL468_15960 ENOG4105CRQ synthase (Component I) AL468_15970 ENOG4105DB7 PHP domain protein AL468_15975 ENOG4107RTD sua5 ycio yrdc ywlc family protein AL468_15985 ENOG4105FE9 pseudouridine synthase AL468_15990 ENOG4108W5H UPF0263 protein AL468_16005 ENOG4105CQ2 DNA polymerase AL468_16010 ENOG4105WH1 Two component transcriptional regulator luxr family AL468_16015 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AL468_16055 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) AL468_16080 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL468_16085 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL468_16090 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL468_16095 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_16110 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AL468_16120 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL468_16125 ENOG4105DVI reductase, NrfD AL468_16130 ENOG4105DA4 cytochrome c-type biogenesis protein AL468_16135 ENOG4107QX9 Thiol disulfide interChange protein AL468_16140 ENOG4108DMF Cytochrome C biogenesis protein AL468_16150 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AL468_16175 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AL468_16180 ENOG4105EAQ (twin-arginine translocation) pathway signal AL468_16185 ENOG4105C5X domain protein AL468_16200 ENOG4105CH5 extracellular solute-binding protein, family 7 AL468_16210 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL468_16230 ENOG4105C94 Transporter AL468_16235 ENOG4105C8Q Methyl-accepting chemotaxis AL468_16260 ENOG4105VUF Transcriptional regulator AL468_16265 ENOG4108Z8I decarboxylase AL468_16275 ENOG4105KXC Collagenase AL468_16290 ENOG4105CR8 Transcriptional regulator AL468_16295 ENOG4105C8Q Methyl-accepting chemotaxis AL468_16305 ENOG41061MD high-affinity nickel-transporter AL468_16310 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter AL468_16315 ENOG4105C6Z Gluconate AL468_16320 ENOG4105EXW epimerase dehydratase AL468_16325 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AL468_16330 ENOG4105FB2 class II Aldolase AL468_16335 ENOG4105G63 Type III effector Hrp-dependent AL468_16340 ENOG4105ZXK Dehydrogenase AL468_16345 ENOG4105MVE transcriptional regulator AL468_16355 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AL468_16360 ENOG4107R88 Chemotaxis protein (CheV) AL468_16370 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related AL468_16375 ENOG41090JE Utilization Protein AL468_16380 ENOG4105D4P Coproporphyrinogen iii oxidase AL468_16385 ENOG4105WQ5 TonB family AL468_16390 ENOG41090AP transport protein AL468_16395 ENOG4106GFD transport protein AL468_16405 ENOG4105EHG Permease protein AL468_16410 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AL468_16450 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AL468_16455 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AL468_16460 ENOG4105QVC MOSC domain-containing protein AL468_16460 ENOG4105QVC MOSC domain-containing protein AL468_16475 ENOG4105EKE dihydroorotase AL468_16480 ENOG4105CKW Inner membrane protein yedI AL468_16510 ENOG4105EG2 ABC transporter, permease AL468_16515 ENOG4105D56 permease protein AL468_16520 ENOG4107FKK extracellular solute-binding protein family 1 AL468_16525 ENOG4108IJ9 (ABC) transporter AL468_16530 ENOG4105D3Q Sugar transferase AL468_16545 ENOG4108F2G Chain length determinant protein AL468_16585 ENOG4105V0I UPF0267 protein AL468_16590 ENOG4108WUH Transcriptional regulator, TetR family AL468_16595 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AL468_16600 ENOG4108RXX maleylacetoacetate isomerase AL468_16605 ENOG4105CH6 catalase AL468_16610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL468_16615 ENOG4105DM4 PTS System AL468_16620 ENOG4108YRF PTS System AL468_16630 ENOG4106R3P AraC family transcriptional regulator AL468_16635 ENOG4105DM4 PTS System AL468_16640 ENOG4105EIP mannose-6-phosphate isomerase AL468_16660 ENOG4108JUA Transcriptional regulator AL468_16665 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AL468_16675 ENOG4105CK1 PTS System AL468_16685 ENOG4105CJP fad dependent oxidoreductase AL468_16690 ENOG4107QZF nitrite reductase NADPH large subunit AL468_16695 ENOG4105C26 Dehydrogenase AL468_16700 ENOG4105DVW rieske (2Fe-2S) AL468_16710 ENOG4105ETT transcriptional Regulator, LysR family AL468_16715 ENOG4105CZN Potassium uptake protein AL468_16725 ENOG4105EEX Two component transcriptional regulator (Winged helix family AL468_16730 ENOG4105BZU Histidine kinase AL468_16735 ENOG4105BZ1 (ABC) transporter AL468_16740 ENOG4105E0K tonB-dependent siderophore receptor AL468_16745 ENOG4105E0A ABC, transporter AL468_16750 ENOG4108HUF Transporter AL468_16755 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL468_16770 ENOG4108JJ6 Type I secretion system ATPase AL468_16780 ENOG41086KC Transcriptional regulator AL468_16785 ENOG41086KC Transcriptional regulator AL468_16795 ENOG41069D7 Methyl-accepting chemotaxis AL468_16805 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL468_16820 ENOG4107QVM von Willebrand factor, type A AL468_16840 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL468_16845 ENOG4105E2Z phosphate ABC transporter (Permease AL468_16850 ENOG4105C8U phosphate abc transporter AL468_16855 ENOG4107S17 Phosphate-binding protein AL468_16860 ENOG4108NVR Methyl-accepting chemotaxis AL468_16880 ENOG4105D05 Receptor AL468_16885 ENOG4105CUG Oligopeptidase b AL468_16890 ENOG4105C1J atp-dependent rna helicase AL468_16900 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AL468_16905 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL468_16910 ENOG4108XDN Transcriptional regulator AL468_16915 ENOG4107SEY Conserved Protein AL468_16920 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL468_16935 ENOG4106TD9 Diguanylate cyclase AL468_16940 ENOG4105KK7 inner membrane protein YiaW AL468_16945 ENOG4105EFX secretion protein, HlyD family AL468_16950 ENOG4108V7D UPF0397 protein AL468_16955 ENOG4108JJB ABC transporter AL468_16975 ENOG4105GXZ Ferredoxin-type protein NapH AL468_16980 ENOG4108BGM Quinol dehydrogenase periplasmic component AL468_16985 ENOG4105WCN acetyltransferase AL468_17000 ENOG4105YE1 PilZ domain AL468_17005 ENOG4107QE9 Inherit from COG: Membrane AL468_17010 ENOG4105C8Q Methyl-accepting chemotaxis AL468_17015 ENOG4105DAN ATP-dependent protease AL468_17025 ENOG4108JQ5 ABC transporter AL468_17035 ENOG410642W LysR family Transcriptional regulator AL468_17040 ENOG4105DAA L-lactate AL468_17045 ENOG4105DMF Dehydrogenase AL468_17055 ENOG4105D64 Mechanosensitive ion channel AL468_17065 ENOG4105CPQ Dehydrogenase AL468_17070 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL468_17075 ENOG4105BZU Histidine kinase AL468_17080 ENOG4107R0W ABC transporter AL468_17090 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL468_17100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL468_17120 ENOG4105EXG Transcriptional regulator AL468_17125 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AL468_17140 ENOG4107SSZ Phosphatase AL468_17170 ENOG4108JIR Flagellum-specific ATP synthase AL468_17180 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL468_17185 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL468_17195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_17210 ENOG4105DD5 Flagellar motor switch protein AL468_17215 ENOG4105CN7 Flagellar biosynthetic protein FliP AL468_17220 ENOG4105VS8 Flagellar biosynthetic protein fliq AL468_17225 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL468_17230 ENOG4105D00 flagellar biosynthetic protein flhB AL468_17245 ENOG4105I03 Flagellin AL468_17255 ENOG410804A Flagellar hook-associated 2 domain-containing protein AL468_17260 ENOG4105MQ3 flagellar protein FliS AL468_17285 ENOG4107RD7 Flagellar Motor Protein, MotA AL468_17290 ENOG4105ER2 Ompa motb domain protein AL468_17305 ENOG4105KWG Pfam:DUF1696 AL468_17345 ENOG4105C6N Formate acetyltransferase AL468_17350 ENOG4105F1A Pyruvate formate-lyase AL468_17355 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL468_17365 ENOG4105I4A GCN5-related N-acetyltransferase AL468_17375 ENOG4105CNH Multidrug resistance protein MdtL AL468_17380 ENOG4105G2Y Transcriptional regulator AL468_17420 ENOG4105IPI Membrane AL468_17425 ENOG41068P6 UPF0319 protein AL468_17430 ENOG4105DP0 ferredoxin-NADP reductase AL468_17440 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL468_17445 ENOG4105ETT transcriptional Regulator, LysR family AL468_17455 ENOG4108RCM Nitroreductase AL468_17460 ENOG4108ZX5 transcriptional regulator AL468_17470 ENOG4105DZ1 carboxypeptidase AL468_17485 ENOG4105C72 UPF0176 protein AL468_17495 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL468_17505 ENOG4108M1A Chitin-binding protein AL468_17510 ENOG4108NRW Phospholipase, patatin family AL468_17515 ENOG41081FY multiple antibiotic resistance (MarC)-related AL468_17530 ENOG4105DAY polysaccharide export protein AL468_17535 ENOG4105KJF protein tyrosine phosphatase AL468_17550 ENOG4105CK2 sodium dicarboxylate symporter AL468_17560 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL468_17565 ENOG4108P2H Inner membrane protein YjiG AL468_17570 ENOG41074DU domain protein AL468_17585 ENOG4107T9C Alpha amylase catalytic region AL468_17590 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AL468_17595 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AL468_17600 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AL468_17605 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AL468_17615 ENOG41061ZR Transcriptional regulator AL468_17640 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL468_17645 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AL468_17650 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AL468_17660 ENOG4105D5Q Arginine ornithine antiporter AL468_17665 ENOG4105CXN decarboxylase AL468_17685 ENOG4108K8S endonuclease I AL468_17705 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AL468_17750 ENOG4105DR5 peptidase AL468_17760 ENOG4107RAN Peptidase, M16 AL468_17765 ENOG4105C8Q Methyl-accepting chemotaxis AL468_17770 ENOG4105E0A ABC, transporter AL468_17775 ENOG4108U1V ABC transporter, permease AL468_17780 ENOG4105DQ5 transport system permease protein AL468_17785 ENOG4108HUF Transporter AL468_17790 ENOG4105GAV receptor AL468_17795 ENOG4105E0K tonB-dependent siderophore receptor AL468_17805 ENOG4105DUU IucA IucC family protein AL468_17815 ENOG4105DBM Siderophore biosynthesis protein AL468_17820 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL468_17825 ENOG4108JP0 extracellular solute-binding protein family 1 AL468_17830 ENOG4105DHQ Histidine kinase AL468_17835 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL468_17845 ENOG4105CI1 PTS System AL468_17860 ENOG4106371 Methyltransferase AL468_17870 ENOG4105CKK Glycosyl transferase, family 2 AL468_17910 ENOG4108ZHJ Organic hydroperoxide resistance protein AL468_17915 ENOG4105K56 Transcriptional regulator AL468_17920 ENOG4105D3R alkyl hydroperoxide reductase AL468_17925 ENOG4108JU3 Alkyl hydroperoxide reductase AL468_17940 ENOG4105EXG Transcriptional regulator AL468_17945 ENOG4105ECQ AraC Family Transcriptional Regulator AL468_17950 ENOG4108AEY RNA polymerase sigma factor AL468_17970 ENOG4108RPX mosc domain containing protein AL468_17995 ENOG4105CF7 AraC family transcriptional regulator AL468_18005 ENOG4105BZ1 (ABC) transporter AL468_18015 ENOG4105EW9 transcriptional regulator AsnC family AL468_18025 ENOG4105KNA -acetyltransferase AL468_18040 ENOG4105CK7 Sodium proline symporter AL468_18050 ENOG4105C26 Dehydrogenase AL468_18065 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AL468_18070 ENOG4105CQZ Histidine kinase AL468_18075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_18080 ENOG4107QZV Type I secretion membrane fusion protein AL468_18120 ENOG4108J59 Extracellular solute-binding protein, family 5 AL468_18130 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) AL468_18140 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL468_18145 ENOG4105C5Y PTS System AL468_18150 ENOG4105FCK Membrane AL468_18155 ENOG4105EC3 peptidase S51, dipeptidase E AL468_18160 ENOG4105EQ2 LysR family Transcriptional regulator AL468_18175 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AL468_18200 ENOG4108JQ7 (ABC) transporter AL468_18225 ENOG4105BZU Histidine kinase AL468_18235 ENOG4105CDY transcriptional regulatory protein AL468_18240 ENOG4105CNI cell division protein FtsW AL468_18250 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL468_18270 ENOG4108HRK Histidine kinase AL468_18275 ENOG4108VAC response regulator AL468_18285 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL468_18290 ENOG4105C8Q Methyl-accepting chemotaxis AL468_18305 ENOG4105D6U Sodium Glutamate Symporter AL468_18315 ENOG4105CZV ABC transporter AL468_18320 ENOG4107U9B transcriptional regulator AL468_18325 ENOG4105D6U Sodium Glutamate Symporter AL468_18335 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AL468_18355 ENOG4105C2I pirin domain protein AL468_18360 ENOG4108VGI doxx family AL468_18370 ENOG4105D03 DNA-3-methyladenine glycosylase II AL468_18395 ENOG4105DN9 Na H antiporter AL468_18410 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_18425 ENOG4105NBK UPF0345 protein AL468_18435 ENOG4105BZU Histidine kinase AL468_18440 ENOG4105UQX Mate efflux family protein AL468_18445 ENOG4105D3G Pseudouridine synthase AL468_18460 ENOG4105EJC lysr family transcriptional regulator AL468_18465 ENOG4108HCJ Hydrolase AL468_18475 ENOG4108KHX Diguanylate cyclase AL468_18485 ENOG4105C4W S-formylglutathione hydrolase AL468_18495 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AL468_18500 ENOG4105CC0 LysR family Transcriptional regulator AL468_18505 ENOG4105Q26 Siderophore-interacting protein AL468_18520 ENOG4105EW9 transcriptional regulator AsnC family AL468_18540 ENOG4107W31 Pentapeptide repeat protein AL468_18545 ENOG4105EIF outer membrane protein W AL468_18555 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL468_18575 ENOG4107WCA isomerase AL468_18580 ENOG4108UVJ appr-1-p processing domain protein AL468_18585 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AL468_18590 ENOG4108WAV Transcriptional regulator AL468_18635 ENOG4105BZU Histidine kinase AL468_18670 ENOG4105VEQ Cold shock protein AL468_18675 ENOG4107QM5 aconitate hydratase AL468_18680 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AL468_18690 ENOG4107QJR hflk protein AL468_18700 ENOG4105VEQ Cold shock protein AL468_18705 ENOG4105CZN Potassium uptake protein AL468_18715 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL468_18720 ENOG4105EEX Two component transcriptional regulator (Winged helix family AL468_18725 ENOG4105C08 Histidine kinase AL468_18730 ENOG4105D64 Mechanosensitive ion channel AL468_18735 ENOG4105CJ2 (LipO)protein AL468_18745 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AL468_18795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL468_18955 ENOG4105S8Q sugar efflux transporter AL468_18985 ENOG41079PT Aminoacyl carrier protein. Can be charged with L-glycine via the formation of a thioester bond between the amino acid and the 4'-phosphopantetheinyl prosthetic group, catalyzed by the AL468_18995 ENOG4105C0W non-ribosomal peptide synthetase AL468_19010 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_19015 ENOG4108TSE Transferase AL468_19060 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AL468_19085 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AL468_19090 ENOG4105C6Z Gluconate AL468_19095 ENOG4105BZW Glycerate kinase AL468_19100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_19135 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL468_19140 ENOG41068WN AL468_19145 ENOG4105CUW cytochrome C-TYPE protein AL468_19150 ENOG4107QY8 reductase AL468_19160 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AL468_19165 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AL468_19170 ENOG4105ETU transcriptional activator (TenA AL468_19175 ENOG4107Z6I Thiamine biosynthesis protein AL468_19180 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AL468_19185 ENOG4108YI8 ABC transporter AL468_19190 ENOG4105DWF phosphomethylpyrimidine kinase AL468_19205 ENOG4108TEM pseudouridine methyltransferase AL468_19260 ENOG4108YYI Protein of unknown function (DUF2810) AL468_19265 ENOG4105C5I Dehydrogenase AL468_19275 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AL468_19280 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AL468_19285 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL468_19290 ENOG410804D Sensor Signal Transduction Histidine Kinase AL468_19315 ENOG4109015 Biopolymer transport protein exbD tolR AL468_19360 ENOG4105DSE periplasmic solute binding protein AL468_19365 ENOG4105DIK (ABC) transporter AL468_19370 ENOG4105CC5 ABC transporter AL468_19385 ENOG4105CUG Oligopeptidase b AL468_19390 ENOG4105E5M Multidrug resistance protein D AL468_19395 ENOG4105CYW agmatinase AL468_19400 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AL468_19410 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_19415 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_19420 ENOG4105DUM transcriptional regulator, lysR family AL468_19465 ENOG4106TD9 Diguanylate cyclase AL468_19470 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL468_19490 ENOG4105D5U fad dependent oxidoreductase AL468_19495 ENOG4108MTT Glutamate-rich protein grpB AL468_19515 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL468_19520 ENOG4105C4M (Ubiquinol oxidase) subunit I AL468_19525 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_19530 ENOG4105C0F tryptophanase EC 4.1.99.1 AL468_19550 ENOG4105D9N nucleoside AL468_19565 ENOG4105BZU Histidine kinase AL468_19580 ENOG4106TD9 Diguanylate cyclase AL468_19585 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL468_19590 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AL468_19605 ENOG4105E0X reductase AL468_19610 ENOG4108UKZ OsmC family AL468_19615 ENOG4108UW5 maltose o-acetyltransferase AL468_19650 ENOG4105JQN Transcriptional regulator AL468_19655 ENOG4105PAD Hydrolase AL468_19670 ENOG4108UUE Transcriptional regulator AL468_19680 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_19690 ENOG4105KUU lipolytic protein G-D-S-L family AL468_19695 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AL468_19720 ENOG4105ETE Transcriptional regulator (LacI family AL468_19725 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AL468_19730 ENOG4108JPW Aminotransferase AL468_19750 ENOG4107RCV ABC transporter, permease AL468_19770 ENOG4108MJ5 VirK protein AL468_19780 ENOG4105CJP fad dependent oxidoreductase AL468_19795 ENOG4105ETT transcriptional Regulator, LysR family AL468_19815 ENOG4105DUX Transporter AL468_19820 ENOG4105EJQ L-serine dehydratase AL468_19840 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL468_19845 ENOG4105E4C Lytic transglycosylase catalytic AL468_19865 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL468_19870 ENOG4108ZC9 flagellar basal-body rod protein flgc AL468_19875 ENOG4105W00 Flagellar hook capping protein AL468_19880 ENOG4105BZE flagellar hook protein, FlgE AL468_19885 ENOG4108KPB Flagellar basal-body rod protein FlgF AL468_19890 ENOG4105CGA flagellar basal-body rod protein FlgG AL468_19895 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_19900 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_19905 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL468_19910 ENOG4105E1Q flagellar hook-associated protein AL468_19915 ENOG4105DTJ flagellar hook-associated protein AL468_19935 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AL468_19950 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL468_19955 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL468_19960 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL468_19990 ENOG4107Z3H Transcriptional regulator, TetR family AL468_19995 ENOG4108K3Z AraC family transcriptional regulator AL468_20000 ENOG4105CPD ethanolamine ammonia-lyase AL468_20005 ENOG4107FQ9 ethanolamine ammonia-lyase AL468_20010 ENOG4105CUB amino acid AL468_20015 ENOG4105EA8 2-Nitropropane dioxygenase AL468_20020 ENOG4105CWX Alpha-1,2-mannosidase AL468_20025 ENOG4105CWX Alpha-1,2-mannosidase AL468_20035 ENOG4105CWX Alpha-1,2-mannosidase AL468_20040 ENOG4105CWX Alpha-1,2-mannosidase AL468_20045 ENOG4105DM4 PTS System AL468_20055 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL468_20060 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AL468_20065 ENOG4105N2W Transcriptional regulator AL468_20075 ENOG4108RWI nicotinamidase AL468_20085 ENOG4107RH7 Nicotinate phosphoribosyltransferase AL468_20110 ENOG4105ETT transcriptional Regulator, LysR family AL468_20125 ENOG4105RW8 MltA-interacting MipA family protein AL468_20130 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AL468_20135 ENOG4108IJ7 Glycine betaine AL468_20140 ENOG4108HQS Glycine betaine AL468_20150 ENOG4105VYW UPF0251 protein AL468_20175 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL468_20185 ENOG4107S8C mandelate racemase muconate lactonizing AL468_20195 ENOG4105RQF LysR family Transcriptional regulator AL468_20210 ENOG4108Z4X TRANSCRIPTIONal AL468_20235 ENOG4107RZC phospholipase d AL468_20265 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_20320 ENOG4107KET secretion protein, HlyD family AL468_20335 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL468_20340 ENOG4105WH1 Two component transcriptional regulator luxr family AL468_20355 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AL468_20360 ENOG4105HDK L-asparaginase AL468_20365 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL468_20380 ENOG4105N14 lysine exporter protein LysE YggA AL468_20385 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AL468_20405 ENOG4105C8Y Acetylornithine aminotransferase AL468_20410 ENOG4105C26 Dehydrogenase AL468_20415 ENOG4108RYR transcriptional regulator AsnC family AL468_20420 ENOG4108KJ1 Trap dicarboxylate transporter, dctp subunit AL468_20425 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase AL468_20430 ENOG4105ENR peptidase, M24 AL468_20435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_20440 ENOG4108K1J Transporter DctQ AL468_20445 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL468_20450 ENOG4108NKV transcriptional regulator AL468_20455 ENOG4105CHR reductase AL468_20465 ENOG4105CPQ Dehydrogenase AL468_20470 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_20485 ENOG4107RSM transcriptional regulator AL468_20495 ENOG4105C1J atp-dependent rna helicase AL468_20535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_20540 ENOG410874W AraC family transcriptional regulator AL468_20560 ENOG4108P3C AL468_20575 ENOG4105CHR reductase AL468_20600 ENOG4105C5Y PTS System AL468_20605 ENOG4105D7K pfkb domain protein AL468_20610 ENOG4108HKT sucrose-6-phosphate hydrolase AL468_20620 ENOG4105CYM Glutathione S-transferase AL468_20630 ENOG4105DZ1 carboxypeptidase AL468_20640 ENOG4105EHV domain protein AL468_20645 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL468_20660 ENOG4105VEQ Cold shock protein AL468_20665 ENOG4105EUB pirin domain protein AL468_20670 ENOG4108NRW Phospholipase, patatin family AL468_20685 ENOG4105EP9 oxidoreductase AL468_20690 ENOG4105DIJ Phosphoethanolamine transferase AL468_20695 ENOG41080IJ Diacylglycerol kinase AL468_20705 ENOG4105E0F Histidine kinase AL468_20710 ENOG4107EXC regulatoR AL468_20725 ENOG4108Z33 Thiol disulfide Interchange Protein AL468_20745 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AL468_20755 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL468_20770 ENOG4105EST Metal Dependent Phosphohydrolase AL468_20775 ENOG4105DZC cytosine deaminase AL468_20780 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin AL468_20785 ENOG4105CJW magnesium transporter AL468_20790 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL468_20795 ENOG4105EFX secretion protein, HlyD family AL468_20820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL468_20825 ENOG4105E0F Histidine kinase AL468_20840 ENOG4105DVH amino acid AL468_20855 ENOG4105DUM transcriptional regulator, lysR family AL468_20880 ENOG4105BZU Histidine kinase AL468_20890 ENOG41090HJ UPF0265 protein AL468_20900 ENOG4108YXG UPF0502 protein AL468_20905 ENOG41082IR Excinuclease ABC C subunit domain protein AL468_20915 ENOG4108QGH periplasmic AL468_20920 ENOG4105BZU Histidine kinase AL468_20930 ENOG4105J12 Multidrug resistance protein mdtN AL468_20950 ENOG4105EW9 transcriptional regulator AsnC family AL468_20980 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_20985 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_21005 ENOG4105CHU acetyl-coa acetyltransferase AL468_21015 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AL468_21025 ENOG4105CUW cytochrome C-TYPE protein AL468_21035 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL468_21050 ENOG4105BZU Histidine kinase AL468_21055 ENOG4105WH1 Two component transcriptional regulator luxr family AL468_21070 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL468_21075 ENOG4107YWA deoxycytidylate deaminase AL468_21090 ENOG4108N3W hemolysin secretion protein AL468_21095 ENOG4108YZN class I peptide chain release factor AL468_21100 ENOG4107VXZ Hydrolase AL468_21105 ENOG4105UYK outer membrane protein a AL468_21115 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL468_21120 ENOG4105DXI Major Facilitator superfamily AL468_21125 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AL468_21130 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL468_21135 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL468_21160 ENOG4105BZU Histidine kinase AL468_21165 ENOG4105KHC sulfurtransferase AL468_21185 ENOG4105D06 uba thif-type nad fad binding protein AL468_21190 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL468_21195 ENOG4105EUJ GTP cyclohydrolase i AL468_21200 ENOG4105C5A transporter AL468_21210 ENOG4105CMQ Chloride channel AL468_21225 ENOG4107RGM aldo keto reductase AL468_21230 ENOG4108UNF response regulator AL468_21240 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AL468_21245 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL468_21250 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_21265 ENOG4105DQU oxidoreductase, subunit beta AL468_21270 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AL468_21280 ENOG4105DR5 peptidase AL468_21305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_21310 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_21315 ENOG4108WC9 type VI secretion system effector, hcp1 family AL468_21320 ENOG4105CS6 Rhs element vgr protein AL468_21345 ENOG4105D9P serine threonine protein kinase AL468_21380 ENOG4105EW9 transcriptional regulator AsnC family AL468_21450 ENOG4105ENX hydrolase AL468_21455 ENOG4105C2C drug resistance transporter, Bcr CflA AL468_21465 ENOG4105CC0 LysR family Transcriptional regulator AL468_21470 ENOG4105EMU Dehydrogenase AL468_21475 ENOG4105Q9Y Universal stress protein AL468_21485 ENOG4105D65 subunit l AL468_21490 ENOG4105MKQ Monovalent cation H antiporter subunit C AL468_21495 ENOG4108JPZ Monovalent cation H antiporter subunit D AL468_21500 ENOG4105SC1 monovalent cation H antiporter subunit E AL468_21505 ENOG41080TA Multiple resistance and ph regulation protein f AL468_21510 ENOG4105KJM monovalent cation h antiporter subunit g AL468_21515 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_21520 ENOG4105C10 Electron transfer flavoprotein AL468_21525 ENOG4105BZJ Electron transfer flavoprotein AL468_21530 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL468_21540 ENOG4105C0Z ABC transporter AL468_21565 ENOG4108IV0 ABC, transporter AL468_21570 ENOG4105DZS Phenylacetate-CoA ligase AL468_21600 ENOG4105C94 Transporter AL468_21605 ENOG4105CHR reductase AL468_21610 ENOG4105C7K acetolactate synthase AL468_21615 ENOG4107FQX Alpha-acetolactate decarboxylase AL468_21625 ENOG4107YBY Hydrolase AL468_21630 ENOG4108S58 Phenazine biosynthesis protein PhzF AL468_21640 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL468_21645 ENOG4105C4M (Ubiquinol oxidase) subunit I AL468_21650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_21670 ENOG4105BZU Histidine kinase AL468_21675 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL468_21685 ENOG4108IPT Naphthoate synthase AL468_21690 ENOG4107QX3 carboxylase AL468_21695 ENOG4105C1G acyl-Coa dehydrogenase AL468_21705 ENOG4105CHU acetyl-coa acetyltransferase AL468_21710 ENOG4105C26 Dehydrogenase AL468_21715 ENOG4105C1G acyl-Coa dehydrogenase AL468_21720 ENOG4105E39 Enoyl-CoA hydratase AL468_21730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL468_21735 ENOG4105CHR reductase AL468_21740 ENOG4105BZU Histidine kinase AL468_21745 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AL468_21750 ENOG4105C26 Dehydrogenase AL468_21755 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AL468_21765 ENOG4108HQS Glycine betaine AL468_21770 ENOG4108IJ7 Glycine betaine AL468_21775 ENOG4108RCM Nitroreductase AL468_21785 ENOG4107QX8 SPFH domain, Band 7 family protein AL468_21795 ENOG4105BZU Histidine kinase AL468_21800 ENOG4105CA0 peroxidase AL468_21805 ENOG4105BZU Histidine kinase AL468_21815 ENOG4105D82 Glutamate dehydrogenase AL468_21865 ENOG4108K0B C-di-gmp phosphodiesterase AL468_21870 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AL468_21875 ENOG4105C2J ABC transporter AL468_21880 ENOG4105CNN ABC, transporter AL468_21885 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AL468_21890 ENOG4108RVA ribokinase AL468_21895 ENOG4105ETE Transcriptional regulator (LacI family AL468_21905 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AL468_21910 ENOG4108I5U Uridine phosphorylase AL468_21925 ENOG4105DHS permease protein AL468_21930 ENOG4105CM4 permease protein AL468_21935 ENOG4108IPW abc transporter atp-binding protein AL468_21940 ENOG4108Z6Z Transcriptional regulator AL468_21945 ENOG4108W3Q Transcriptional regulator AL468_21980 ENOG4105EM2 membrane AL468_21985 ENOG41088T4 Helicase IV AL468_21990 ENOG4108Z5K methylglyoxal synthase AL468_21995 ENOG4108SV3 Tmao reductase system periplasmic protein tort AL468_22000 ENOG4105BZU Histidine kinase AL468_22020 ENOG4105ENH Sulfatase AL468_22030 ENOG41061MV Arylsulfatase AL468_22035 ENOG4105C4X radical SAM domain protein AL468_22040 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL468_22070 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL468_22075 ENOG41064T2 transcriptional regulator, lysR family AL468_22080 ENOG4107TE5 Lipid kinase AL468_22085 ENOG4108YDI single-species biofilm formation on inanimate substrate AL468_22095 ENOG4105F2V VRR-NUC domain-containing protein AL468_22110 ENOG4105D0M Protease HtpX homolog AL468_22115 ENOG4108V0P LemA family AL468_22120 ENOG4105CEE C4-dicarboxylate transporter AL468_22140 ENOG4108MGY Histidine kinase AL468_22145 ENOG4107KBT 8-Amino-7-oxononanoate synthase AL468_22150 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AL468_22155 ENOG4105BZU Histidine kinase AL468_22160 ENOG4105BZU Histidine kinase AL468_22170 ENOG4108WQH regulatoR AL468_22175 ENOG4107R88 Chemotaxis protein (CheV) AL468_22180 ENOG4108VAU general secretion pathway protein G AL468_22190 ENOG4105FR1 rard protein AL468_22220 ENOG4105KPY Small multidrug resistance protein AL468_22225 ENOG4108I0N Transporter, RarD family, DMT superfamily protein AL468_22240 ENOG4107RGH Aldehyde dehydrogenase AL468_22250 ENOG4105CBC glutamate synthase AL468_22255 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AL468_22280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_22285 ENOG4108UYE Lactoylglutathione lyase AL468_22305 ENOG4105CJW magnesium transporter AL468_22335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL468_22350 ENOG4105HDD phospholipase AL468_22375 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AL468_22410 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AL468_22415 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AL468_22420 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL468_22430 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AL468_22440 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL468_22460 ENOG4105DM4 PTS System AL468_22465 ENOG4105DE4 1-phosphofructokinase AL468_22470 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AL468_22475 ENOG4107B7Y DNA-binding transcriptional regulator FruR AL468_22490 ENOG4108NJZ Sensory box GGDEF EAL domain protein AL468_22495 ENOG4105DRP amino acid AbC transporter AL468_22500 ENOG4106TNF Periplasmic binding protein AL468_22505 ENOG4105E5Q amino acid AbC transporter AL468_22510 ENOG4105CDA abc transporter atp-binding protein AL468_22520 ENOG4108I6A alcohol dehydrogenase AL468_22525 ENOG4105CF7 AraC family transcriptional regulator AL468_22540 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL468_22545 ENOG4105CKU formyltetrahydrofolate synthetase AL468_22550 ENOG4107RE1 Inosine-guanosine kinase AL468_22565 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL468_22585 ENOG4108ZYK Acyl carrier protein phosphodiesterase AL468_22590 ENOG4105C1J atp-dependent rna helicase AL468_22595 ENOG4108M8H domain protein AL468_22610 ENOG4105DS1 cytochrome b561 AL468_22615 ENOG4108YYC ycei family AL468_22620 ENOG4105TMB Formate nitrite transporter AL468_22630 ENOG4105DUM transcriptional regulator, lysR family AL468_22635 ENOG4108UQ5 membrane protein YcdZ AL468_22640 ENOG4105CPB ATP-dependent endonuclease of the OLD family AL468_22645 ENOG4105CGH 5'-nucleotidase AL468_22650 ENOG4105DU1 integral membrane protein, terc AL468_22670 ENOG4108M0H Extracellular lipase AL468_22675 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_22690 ENOG4105KA0 thioesterase Superfamily protein AL468_22700 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AL468_22740 ENOG4105RKW reductase (By AL468_22750 ENOG4108I0Y (ABC) transporter AL468_22755 ENOG4105CV6 ABC transporter, permease AL468_22765 ENOG4107R7A Allophanate hydrolase subunit 2 AL468_22770 ENOG4105P4J Allophanate hydrolase, subunit 1 AL468_22775 ENOG4105E7W lamb ycsf family protein AL468_22780 ENOG4105BZU Histidine kinase AL468_22785 ENOG4105CMR udp-glucose 4-epimerase AL468_22800 ENOG4105CWB LysR family transcriptional Regulator AL468_22805 ENOG4105CD5 CoA-binding domain protein AL468_22815 ENOG4105CPF Cell wall formation (By similarity) AL468_22825 ENOG4108ZJT translation initiation factor, Sui1 AL468_22875 ENOG4105MQ5 zona occludens toxin AL468_22905 ENOG4105EJC lysr family transcriptional regulator AL468_22915 ENOG4108M6U Universal stress protein A AL468_22945 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL468_22950 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL468_22965 ENOG4105BZU Histidine kinase AL468_22985 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AL468_22990 ENOG4105E0C molybdate abc transporter AL468_22995 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AL468_23000 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AL468_23005 ENOG4105WXI Bacterial OB fold (BOF) protein AL468_23015 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_23020 ENOG4105CGF Aromatic amino acid aminotransferase AL468_23025 ENOG4108K01 transcriptional regulator AL468_23030 ENOG4105UQX Mate efflux family protein AL468_23035 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AL468_23040 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AL468_23055 ENOG4105BZS acriflavin resistance protein AL468_23160 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AL468_23170 ENOG4107TIF Phenazine biosynthesis protein, PhzF family AL468_23180 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AL468_23190 ENOG4105C5Q Transcriptional regulator AL468_23195 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL468_23200 ENOG4105CXY transporter AL468_23205 ENOG4108KX4 response regulator AL468_23210 ENOG4105BZU Histidine kinase AL468_23215 ENOG4105CXY transporter AL468_23220 ENOG4105EIP mannose-6-phosphate isomerase AL468_23240 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL468_23245 ENOG4105K63 Thioredoxin AL468_23250 ENOG4108ISG Major Facilitator AL468_23255 ENOG4105VXR cytoplasmic protein AL468_23285 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL468_23300 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL468_23305 ENOG4105TMB Formate nitrite transporter AL468_23310 ENOG4105WZK nitrite reductase NADPH small subunit AL468_23315 ENOG4107QZF nitrite reductase NADPH large subunit AL468_23320 ENOG4105NXH GreA GreB family elongation factor AL468_23330 ENOG4105BZU Histidine kinase AL468_23405 ENOG4108NVR Methyl-accepting chemotaxis AL468_23410 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL468_23425 ENOG4105EJC lysr family transcriptional regulator AL468_23445 ENOG4105CXG d-lactate dehydrogenase AL468_23450 ENOG4105CC0 LysR family Transcriptional regulator AL468_23465 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AL468_23470 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) AL468_23480 ENOG4105C5W Aldolase AL468_23485 ENOG4106RE7 Cytochrome AL468_23490 ENOG4105CSX c4-dicarboxylate anaerobic carrier AL468_23500 ENOG4105QNF Outer membrane lipoprotein AL468_23510 ENOG4105EYH Exonuclease AL468_23515 ENOG4107RFY SbcCD D subunit AL468_23540 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_23585 ENOG4108ZF3 Phosphatase AL468_23600 ENOG4106VK6 Flagellar motor protein AL468_23620 ENOG4105D9P serine threonine protein kinase AL468_23640 ENOG4105F8J Adenylate Guanylate cyclase AL468_23655 ENOG4108IG5 Transcriptional regulator AL468_23670 ENOG4107QZF nitrite reductase NADPH large subunit AL468_23675 ENOG4105D7T ABC transporter AL468_23680 ENOG4105DG7 nitrate ABC transporter AL468_23710 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL468_23725 ENOG4105C44 Serine transporter AL468_23735 ENOG4105BZU Histidine kinase AL468_23765 ENOG4105ETX regulatoR AL468_23785 ENOG4106E5D Protein of unknown function (DUF461) AL468_23790 ENOG4105R8A Heat shock protein AL468_23805 ENOG4107RUY (E1 component), alpha subunit AL468_23810 ENOG4105CPP Dehydrogenase, E1 component AL468_23815 ENOG4107QSN dihydrolipoamide acetyltransferase AL468_23820 ENOG4105C10 Electron transfer flavoprotein AL468_23825 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL468_23840 ENOG4105UYK outer membrane protein a AL468_23860 ENOG4105DMR ABC, transporter AL468_23865 ENOG4105GBT ABC transporter AL468_23870 ENOG4106PMH Extracellular solute-binding protein family 3 AL468_23875 ENOG4105E5Z arginine transporter ATP-binding subunit AL468_23915 ENOG4105C26 Dehydrogenase AL468_23935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_23945 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL468_23955 ENOG4105CCU oxidase (Subunit III) AL468_23960 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL468_23965 ENOG4105E2S oxidase) subunit II AL468_23970 ENOG4105CHR reductase AL468_23975 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL468_23980 ENOG4105E39 Enoyl-CoA hydratase AL468_23985 ENOG4105E39 Enoyl-CoA hydratase AL468_23995 ENOG4105C26 Dehydrogenase AL468_24000 ENOG4105CHU acetyl-coa acetyltransferase AL468_24010 ENOG4105C1G acyl-Coa dehydrogenase AL468_24015 ENOG4107QX3 carboxylase AL468_24020 ENOG4105E39 Enoyl-CoA hydratase AL468_24025 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL468_24040 ENOG4105CQB FAD linked oxidase domain protein AL468_24050 ENOG4107U2T alpha beta AL468_24055 ENOG4105ECQ AraC Family Transcriptional Regulator AL468_24070 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AL468_24075 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component AL468_24080 ENOG4108IJ8 ABC transporter AL468_24085 ENOG4105E90 ABC transporter AL468_24090 ENOG4107SDU Methyl-accepting chemotaxis AL468_24095 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL468_24105 ENOG4105BZU Histidine kinase AL468_24110 ENOG4105C1J atp-dependent rna helicase AL468_24115 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) AL468_24130 ENOG4105CVA phosphate AL468_24145 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AL468_24150 ENOG4105DKW ABC transporter AL468_24155 ENOG4105CXC rtn protein AL468_24175 ENOG4105C1J atp-dependent rna helicase AL468_24180 ENOG4105CKI cobalamin synthesis protein AL468_24190 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AL468_24200 ENOG4105VEQ Cold shock protein AL468_24205 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AL468_24210 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL468_24220 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL468_24225 ENOG4105C1J atp-dependent rna helicase AL468_24235 ENOG4105HF0 Membrane AL468_24260 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AL468_24280 ENOG4105VRT cytoplasmic protein AL468_24300 ENOG41090A4 Pterin carbinolamine dehydratase AL468_24305 ENOG4105MIR Phenylalanine 4-monooxygenase AL468_24310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_24315 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL468_24340 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AL468_24345 ENOG4105C0A alcohol dehydrogenase AL468_24360 ENOG4108RMU ferritin dps family protein AL468_24365 ENOG4105C8Q Methyl-accepting chemotaxis AL468_24375 ENOG4107R39 (ABC) transporter AL468_24395 ENOG4105BZU Histidine kinase AL468_24405 ENOG4105VEQ Cold shock protein AL468_24425 ENOG4108ZG0 Ompa motb domain protein AL468_24435 ENOG4108V1T peptidylprolyl cis-trans isomerase AL468_24440 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL468_24445 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AL468_24470 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) AL468_24475 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL468_24500 ENOG4105SUT Transcriptional Regulator AraC Family AL468_24515 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AL468_24535 ENOG4108SXK Transporter Drug Metabolite Exporter family AL468_24540 ENOG4105VW4 glutaredoxin 3 AL468_24555 ENOG4105E5M Multidrug resistance protein D AL468_24560 ENOG4105CR8 Transcriptional regulator AL468_24570 ENOG4105DR5 peptidase AL468_24595 ENOG4105DWD nucleoside recognition domain protein AL468_24600 ENOG4105C8Q Methyl-accepting chemotaxis AL468_24610 ENOG4105E0U tyrosine-specific transport protein AL468_24630 ENOG4107Z1W Fructose transport system kinase AL468_24640 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein AL468_24645 ENOG4105CTS PTS system mannitol-specific AL468_24650 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia AL468_24670 ENOG4105D6J arsenicaL-resistance protein AL468_24680 ENOG4108V1U phospholipid-binding protein AL468_24685 ENOG4105JAB phenazine biosynthesis protein, phzf family AL468_24690 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AL468_24700 ENOG4105CJ1 ABC, transporter AL468_24705 ENOG4107QWP ABC-2 type transporter AL468_24745 ENOG4108IJF Heavy metal efflux pump, CzcA AL468_24775 ENOG4108HK0 -acetyltransferase AL468_24785 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_24795 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL468_24810 ENOG4105C5H ABC transporter AL468_24815 ENOG4108M6U Universal stress protein A AL468_24820 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL468_24825 ENOG4105CKD glutathione-regulated potassium-efflux system protein