locus-tag	class	description
HOO69_00070	COG0646	methionine synthase
HOO69_00070	COG1410	methionine synthase
HOO69_00075	COG2239	Acts as a magnesium transporter
HOO69_00080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_00085	COG1660	Displays ATPase and GTPase activities
HOO69_00090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_00095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HOO69_00105	COG1137	ATPase activity
HOO69_00110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HOO69_00120	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HOO69_00125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HOO69_00125	COG0517	IMP dehydrogenase activity
HOO69_00135	COG1127	ABC transporter
HOO69_00140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HOO69_00145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HOO69_00150	COG2854	intermembrane phospholipid transfer
HOO69_00155	COG3113	response to antibiotic
HOO69_00160	COG5007	Belongs to the BolA IbaG family
HOO69_00170	COG0204	Acyl-transferase
HOO69_00235	COG0741	lytic transglycosylase activity
HOO69_00240	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HOO69_00245	COG1194	a g-specific adenine glycosylase
HOO69_00250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HOO69_00255	COG2066	Belongs to the glutaminase family
HOO69_00260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HOO69_00265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HOO69_00280	COG0762	integral membrane protein
HOO69_00285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HOO69_00290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HOO69_00310	COG1918	ferrous iron import across plasma membrane
HOO69_00310	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HOO69_00335	COG1131	(ABC) transporter
HOO69_00345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HOO69_00350	COG1678	Uncharacterized ACR, COG1678
HOO69_00355	COG0189	ligase activity
HOO69_00360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HOO69_00365	COG2356	endonuclease I
HOO69_00380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HOO69_00385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HOO69_00395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HOO69_00405	COG0191	fructose-bisphosphate aldolase activity
HOO69_00410	COG0668	transmembrane transport
HOO69_00425	COG0583	DNA-binding transcription factor activity
HOO69_00435	COG3706	GGDEF domain
HOO69_00450	COG1349	DNA-binding transcription factor activity
HOO69_00455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HOO69_00460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOO69_00465	COG3722	fumarate hydratase activity
HOO69_00470	COG0246	Mannitol dehydrogenase
HOO69_00475	COG2213	PTS system mannitol-specific
HOO69_00475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_00480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HOO69_00490	COG0142	geranyltranstransferase activity
HOO69_00495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HOO69_00505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HOO69_00510	COG3610	response to peptide
HOO69_00515	COG3610	response to peptide
HOO69_00540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HOO69_00550	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HOO69_00555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HOO69_00560	COG0582	viral genome integration into host DNA
HOO69_00645	COG0358	DNA primase activity
HOO69_00650	COG1610	YqeY-like protein
HOO69_00655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HOO69_00660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HOO69_00665	COG2267	carboxylic ester hydrolase activity
HOO69_00675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HOO69_00680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HOO69_00690	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HOO69_00695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HOO69_00700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HOO69_00705	COG0585	pseudouridine synthase activity
HOO69_00725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HOO69_00730	COG4536	flavin adenine dinucleotide binding
HOO69_00735	COG4137	Cytochrome C assembly protein
HOO69_00740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HOO69_00750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HOO69_00765	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HOO69_00770	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HOO69_00775	COG0237	dephospho-CoA kinase activity
HOO69_00785	COG1459	type II secretion system
HOO69_00790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HOO69_00800	COG0157	Belongs to the NadC ModD family
HOO69_00810	COG0716	FMN binding
HOO69_00815	COG4974	Belongs to the 'phage' integrase family
HOO69_00820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HOO69_00825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HOO69_00830	COG2186	Transcriptional regulator
HOO69_00835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HOO69_00840	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOO69_00845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOO69_00860	COG0288	reversible hydration of carbon dioxide
HOO69_00865	COG0659	secondary active sulfate transmembrane transporter activity
HOO69_00870	COG1131	(ABC) transporter
HOO69_00875	COG0842	Transport permease protein
HOO69_00890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HOO69_00905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HOO69_00915	COG1643	Atp-dependent helicase
HOO69_00920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HOO69_00925	COG1752	Esterase of the alpha-beta hydrolase superfamily
HOO69_00935	COG3112	Uncharacterised protein family (UPF0231)
HOO69_00945	COG0004	ammonium transporteR
HOO69_00950	COG1840	ABC-type Fe3 transport system, periplasmic component
HOO69_00960	COG3842	ATPase activity
HOO69_00965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOO69_00980	COG2971	BadF BadG BcrA BcrD
HOO69_00990	COG4608	Belongs to the ABC transporter superfamily
HOO69_00995	COG0444	Belongs to the ABC transporter superfamily
HOO69_01000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOO69_01010	COG0747	negative chemotaxis
HOO69_01015	COG2205	protein histidine kinase activity
HOO69_01015	COG2198	Histidine kinase
HOO69_01015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_01015	COG0784	Response regulator, receiver
HOO69_01020	COG2813	Specifically methylates the guanine in position
HOO69_01025	COG0628	permease
HOO69_01030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HOO69_01050	COG0739	heme binding
HOO69_01055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HOO69_01065	COG2027	D-alanyl-D-alanine carboxypeptidase
HOO69_01070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HOO69_01075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HOO69_01080	COG1534	Rna-binding protein
HOO69_01090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HOO69_01095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HOO69_01110	COG0456	acetyltransferase
HOO69_01120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HOO69_01125	COG0513	Belongs to the DEAD box helicase family
HOO69_01130	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HOO69_01145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HOO69_01150	COG2204	response regulator
HOO69_01160	COG0667	Aldo Keto reductase
HOO69_01170	COG3066	DNA modification
HOO69_01185	COG0730	response to heat
HOO69_01195	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HOO69_01200	COG1283	sodium-dependent phosphate transmembrane transporter activity
HOO69_01205	COG0583	DNA-binding transcription factor activity
HOO69_01210	COG0640	Transcriptional regulator
HOO69_01215	COG0268	Binds directly to 16S ribosomal RNA
HOO69_01220	COG0728	peptidoglycan biosynthetic process
HOO69_01225	COG0196	riboflavin kinase activity
HOO69_01240	COG1047	Peptidyl-prolyl cis-trans
HOO69_01245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HOO69_01250	COG0612	Peptidase, M16
HOO69_01255	COG1966	Carbon starvation protein
HOO69_01265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HOO69_01280	COG3279	Response regulator of the LytR AlgR family
HOO69_01285	COG3275	phosphorelay sensor kinase activity
HOO69_01290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HOO69_01295	COG0287	Prephenate dehydrogenase
HOO69_01295	COG1605	Chorismate mutase
HOO69_01300	COG0739	heme binding
HOO69_01310	COG0488	(ABC) transporter
HOO69_01320	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HOO69_01325	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HOO69_01335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HOO69_01340	COG0077	Prephenate dehydratase
HOO69_01340	COG1605	Chorismate mutase
HOO69_01345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HOO69_01350	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HOO69_01355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO69_01360	COG0564	pseudouridine synthase activity
HOO69_01370	COG0542	response to heat
HOO69_01410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOO69_01415	COG0483	inositol monophosphate 1-phosphatase activity
HOO69_01430	COG1104	cysteine desulfurase activity
HOO69_01435	COG0822	iron-sulfur transferase activity
HOO69_01455	COG0633	Ferredoxin
HOO69_01460	COG2975	iron-sulfur cluster assembly
HOO69_01465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HOO69_01475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HOO69_01480	COG0583	DNA-binding transcription factor activity
HOO69_01490	COG0583	DNA-binding transcription factor activity
HOO69_01495	COG1022	Amp-dependent synthetase and ligase
HOO69_01500	COG2169	Transcriptional regulator
HOO69_01530	COG4964	Belongs to the GSP D family
HOO69_01570	COG0583	DNA-binding transcription factor activity
HOO69_01580	COG1175	transmembrane transport
HOO69_01585	COG0395	ABC-type sugar transport system, permease component
HOO69_01590	COG1653	transport
HOO69_01595	COG3250	beta-galactosidase activity
HOO69_01605	COG3408	Glycogen debranching enzyme
HOO69_01605	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HOO69_01610	COG0662	Cupin 2, conserved barrel domain protein
HOO69_01610	COG2207	Transcriptional regulator
HOO69_01635	COG0531	amino acid
HOO69_01640	COG2731	YhcH YjgK YiaL family protein
HOO69_01645	COG3250	beta-galactosidase activity
HOO69_01650	COG1609	Transcriptional regulator
HOO69_01655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HOO69_01660	COG1085	galactose-1-phosphate uridylyltransferase
HOO69_01670	COG2017	converts alpha-aldose to the beta-anomer
HOO69_01690	COG0583	DNA-binding transcription factor activity
HOO69_01695	COG4989	oxidoreductase activity
HOO69_01705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO69_01720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HOO69_01725	COG1349	DNA-binding transcription factor activity
HOO69_01730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HOO69_01735	COG2271	Major facilitator Superfamily
HOO69_01740	COG2171	N-acyltransferase activity
HOO69_01745	COG0450	alkyl hydroperoxide reductase
HOO69_01750	COG0583	DNA-binding transcription factor activity
HOO69_01755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HOO69_01765	COG0517	IMP dehydrogenase activity
HOO69_01770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HOO69_01780	COG1862	Preprotein translocase
HOO69_01785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO69_01790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO69_01800	COG1879	ABC-type sugar transport system periplasmic component
HOO69_01815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HOO69_01830	COG0745	RESPONSE REGULATOR receiver
HOO69_01835	COG5002	protein histidine kinase activity
HOO69_01845	COG0248	Ppx GppA phosphatase
HOO69_01850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HOO69_01855	COG0573	inorganic phosphate transmembrane transporter activity
HOO69_01860	COG0581	inorganic phosphate transmembrane transporter activity
HOO69_01865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HOO69_01870	COG0704	Plays a role in the regulation of phosphate uptake
HOO69_01895	COG3142	Participates in the control of copper homeostasis
HOO69_01900	COG3141	response to X-ray
HOO69_01905	COG1309	transcriptional regulator
HOO69_01910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO69_01930	COG3284	Transcriptional regulator
HOO69_01935	COG3842	ATPase activity
HOO69_01940	COG3842	ATPase activity
HOO69_01950	COG0395	ABC-type sugar transport system, permease component
HOO69_01965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HOO69_01970	COG1074	ATP-dependent DNA helicase activity
HOO69_01975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HOO69_01995	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HOO69_02000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HOO69_02005	COG2166	iron-sulfur cluster assembly
HOO69_02020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HOO69_02025	COG0124	histidyl-tRNA synthetase
HOO69_02030	COG2976	Protein conserved in bacteria
HOO69_02035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO69_02040	COG1160	GTP binding
HOO69_02050	COG3706	GGDEF domain
HOO69_02065	COG0517	IMP dehydrogenase activity
HOO69_02065	COG0516	GMP reductase activity
HOO69_02070	COG0519	Catalyzes the synthesis of GMP from XMP
HOO69_02070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HOO69_02080	COG1584	GPR1 FUN34 yaaH family protein
HOO69_02085	COG1115	amino acid carrier protein
HOO69_02115	COG2873	o-acetylhomoserine
HOO69_02120	COG1253	flavin adenine dinucleotide binding
HOO69_02125	COG0583	DNA-binding transcription factor activity
HOO69_02135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HOO69_02140	COG0204	Acyl-transferase
HOO69_02145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HOO69_02160	COG0668	transmembrane transport
HOO69_02180	COG0009	L-threonylcarbamoyladenylate synthase
HOO69_02185	COG0579	oxidoreductase
HOO69_02190	COG1473	amidohydrolase
HOO69_02200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HOO69_02225	COG2271	Major facilitator Superfamily
HOO69_02230	COG3851	Histidine kinase
HOO69_02235	COG2197	response regulator
HOO69_02260	COG2867	negative regulation of translational initiation
HOO69_02265	COG2914	Belongs to the UPF0125 (RnfH) family
HOO69_02270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO69_02275	COG0497	DNA recombination
HOO69_02285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HOO69_02290	COG1301	dicarboxylic acid transport
HOO69_02305	COG0443	Heat shock 70 kDa protein
HOO69_02310	COG0484	heat shock protein binding
HOO69_02340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HOO69_02355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HOO69_02360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOO69_02360	COG0047	phosphoribosylformylglycinamidine synthase activity
HOO69_02385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HOO69_02390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HOO69_02395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HOO69_02405	COG2840	Smr protein MutS2
HOO69_02435	COG3104	oligopeptide transport
HOO69_02440	COG0367	asparagine synthase
HOO69_02445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HOO69_02445	COG4651	solute:proton antiporter activity
HOO69_02450	COG1940	carbohydrate kinase activity
HOO69_02450	COG1846	Transcriptional regulator
HOO69_02455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HOO69_02460	COG1263	PTS System
HOO69_02460	COG2190	(PTS) system
HOO69_02460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_02470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOO69_02475	COG0735	belongs to the Fur family
HOO69_02485	COG0716	FMN binding
HOO69_02495	COG0596	Alpha beta hydrolase
HOO69_02500	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HOO69_02505	COG0033	Phosphoglucomutase
HOO69_02515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HOO69_02530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HOO69_02535	COG1053	succinate dehydrogenase
HOO69_02545	COG0567	Dehydrogenase, E1 component
HOO69_02550	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOO69_02585	COG3098	single-species biofilm formation
HOO69_02590	COG0564	pseudouridine synthase activity
HOO69_02600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HOO69_02605	COG0142	geranyltranstransferase activity
HOO69_02615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HOO69_02625	COG0301	tRNA thio-modification
HOO69_02625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HOO69_02630	COG0583	DNA-binding transcription factor activity
HOO69_02640	COG2363	Small membrane protein
HOO69_02645	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HOO69_02655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOO69_02660	COG1611	Belongs to the LOG family
HOO69_02675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HOO69_02675	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HOO69_02695	COG1876	peptidase activity
HOO69_02700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOO69_02705	COG1393	Belongs to the ArsC family
HOO69_02725	COG4235	cytochrome complex assembly
HOO69_02730	COG4221	oxidoreductase activity
HOO69_02735	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HOO69_02745	COG0437	4 iron, 4 sulfur cluster binding
HOO69_02750	COG3301	Polysulphide reductase, NrfD
HOO69_02755	COG1138	Cytochrome C-type biogenesis protein
HOO69_02760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HOO69_02765	COG3088	subunit of a heme lyase
HOO69_02765	COG4235	cytochrome complex assembly
HOO69_02780	COG2837	iron assimilation
HOO69_02795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HOO69_02805	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HOO69_02815	COG1516	flagellar protein fliS
HOO69_02825	COG4191	Histidine kinase
HOO69_02835	COG1677	Flagellar hook-basal body complex protein FliE
HOO69_02845	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HOO69_02870	COG1580	Controls the rotational direction of flagella during chemotaxis
HOO69_02895	COG1987	bacterial-type flagellum assembly
HOO69_02900	COG1684	flagellar biosynthetic protein fliR
HOO69_02915	COG2890	protein-(glutamine-N5) methyltransferase activity
HOO69_02920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HOO69_02925	COG0737	Belongs to the 5'-nucleotidase family
HOO69_02935	COG2860	membrane
HOO69_02940	COG3101	peptidyl-lysine hydroxylation
HOO69_02960	COG0431	NADPH-dependent FMN reductase
HOO69_02970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOO69_02975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HOO69_02980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HOO69_02990	COG0101	tRNA pseudouridine synthase activity
HOO69_02995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HOO69_03000	COG0285	dihydrofolate synthase activity
HOO69_03005	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HOO69_03010	COG1286	toxin biosynthetic process
HOO69_03015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HOO69_03020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HOO69_03025	COG1121	(ABC) transporter
HOO69_03030	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HOO69_03035	COG4977	sequence-specific DNA binding
HOO69_03045	COG1918	ferrous iron import across plasma membrane
HOO69_03050	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HOO69_03065	COG0018	arginyl-trna synthetase
HOO69_03075	COG3102	Protein conserved in bacteria
HOO69_03085	COG2062	phosphohistidine phosphatase, SixA
HOO69_03115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HOO69_03120	COG0784	Response regulator, receiver
HOO69_03120	COG2198	Histidine kinase
HOO69_03120	COG0643	Histidine kinase
HOO69_03130	COG1192	Involved in chromosome partitioning
HOO69_03140	COG0835	chemotaxis
HOO69_03150	COG4133	protoheme IX ABC transporter activity
HOO69_03160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HOO69_03165	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HOO69_03170	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HOO69_03175	COG1138	Cytochrome C-type biogenesis protein
HOO69_03180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HOO69_03185	COG3088	subunit of a heme lyase
HOO69_03185	COG4235	cytochrome complex assembly
HOO69_03200	COG2067	long-chain fatty acid transport protein
HOO69_03205	COG2067	long-chain fatty acid transport protein
HOO69_03220	COG0183	Belongs to the thiolase family
HOO69_03225	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOO69_03225	COG1024	Enoyl-CoA hydratase
HOO69_03230	COG0778	Nitroreductase
HOO69_03240	COG0745	RESPONSE REGULATOR receiver
HOO69_03245	COG2832	Protein of unknown function (DUF454)
HOO69_03250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HOO69_03265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HOO69_03360	COG2983	Belongs to the UPF0260 family
HOO69_03385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HOO69_03385	COG2755	lipolytic protein G-D-S-L family
HOO69_03390	COG0668	transmembrane transport
HOO69_03425	COG2226	methyltransferase
HOO69_03440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HOO69_03445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOO69_03455	COG3139	Protein of unknown function (DUF1315)
HOO69_03460	COG3012	SEC-C Motif Domain Protein
HOO69_03465	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HOO69_03475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HOO69_03480	COG0215	cysteine-tRNA ligase activity
HOO69_03490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HOO69_03495	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HOO69_03520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HOO69_03530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HOO69_03555	COG3070	regulator of competence-specific genes
HOO69_03560	COG1609	Transcriptional regulator
HOO69_03570	COG0745	RESPONSE REGULATOR receiver
HOO69_03575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HOO69_03580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HOO69_03590	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HOO69_03595	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HOO69_03610	COG0318	PFAM AMP-dependent synthetase and ligase
HOO69_03630	COG4067	protein conserved in archaea
HOO69_03630	COG0189	ligase activity
HOO69_03645	COG1801	Protein of unknown function DUF72
HOO69_03655	COG1187	pseudouridine synthase activity
HOO69_03665	COG1278	Cold shock
HOO69_03675	COG0542	response to heat
HOO69_03710	COG2116	formate transmembrane transporter activity
HOO69_03720	COG0390	transport system, permease component
HOO69_03725	COG4459	periplasmic nitrate reductase
HOO69_03730	COG3005	denitrification pathway
HOO69_03735	COG0243	molybdopterin cofactor binding
HOO69_03770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HOO69_03775	COG0840	transmembrane signaling receptor activity
HOO69_03780	COG0632	four-way junction helicase activity
HOO69_03785	COG2255	four-way junction helicase activity
HOO69_03795	COG1294	oxidase, subunit
HOO69_03800	COG4890	Cyd operon protein YbgT
HOO69_03810	COG0824	Thioesterase
HOO69_03815	COG0811	peptide transport
HOO69_03835	COG2885	chlorophyll binding
HOO69_03840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HOO69_03845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HOO69_03850	COG0137	argininosuccinate synthase activity
HOO69_03860	COG2205	protein histidine kinase activity
HOO69_03860	COG0784	Response regulator, receiver
HOO69_03890	COG0270	DNA (cytosine-5-)-methyltransferase activity
HOO69_03910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_03920	COG1482	cell wall glycoprotein biosynthetic process
HOO69_03925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_03925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_03925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_03930	COG2207	Transcriptional regulator
HOO69_03940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_03945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_03950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HOO69_03965	COG3850	Histidine kinase
HOO69_03965	COG5002	protein histidine kinase activity
HOO69_03970	COG0745	RESPONSE REGULATOR receiver
HOO69_03975	COG0463	Glycosyl transferase, family 2
HOO69_03980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HOO69_03995	COG1960	acyl-CoA dehydrogenase activity
HOO69_04010	COG0840	transmembrane signaling receptor activity
HOO69_04015	COG2850	peptidyl-arginine hydroxylation
HOO69_04025	COG3923	Primosomal replication protein n
HOO69_04030	COG0730	response to heat
HOO69_04035	COG1199	ATP-dependent helicase activity
HOO69_04045	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HOO69_04050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HOO69_04070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HOO69_04090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HOO69_04105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HOO69_04115	COG2268	Band 7 protein
HOO69_04125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HOO69_04145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOO69_04155	COG1757	Na H antiporter
HOO69_04165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HOO69_04175	COG0131	Imidazoleglycerol-phosphate dehydratase
HOO69_04175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HOO69_04180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HOO69_04185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HOO69_04205	COG1227	inorganic diphosphatase activity
HOO69_04220	COG4172	Belongs to the ABC transporter superfamily
HOO69_04245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HOO69_04250	COG1842	Phage shock protein A
HOO69_04280	COG0519	Catalyzes the synthesis of GMP from XMP
HOO69_04285	COG5380	lipid catabolic process
HOO69_04290	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HOO69_04295	COG0626	cystathionine gamma-synthase activity
HOO69_04305	COG0733	neurotransmitter:sodium symporter activity
HOO69_04315	COG0564	pseudouridine synthase activity
HOO69_04320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HOO69_04340	COG4964	Belongs to the GSP D family
HOO69_04395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HOO69_04400	COG4136	ATPase activity
HOO69_04405	COG4135	transport system, permease component
HOO69_04410	COG4134	Bacterial extracellular solute-binding protein
HOO69_04420	COG3313	Fe-S protein
HOO69_04440	COG2200	EAL domain
HOO69_04450	COG2350	Protein conserved in bacteria
HOO69_04455	COG1607	acyl-coa hydrolase
HOO69_04495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOO69_04505	COG0417	DNA replication proofreading
HOO69_04510	COG2197	response regulator
HOO69_04515	COG0322	excinuclease ABC activity
HOO69_04545	COG3706	GGDEF domain
HOO69_04550	COG2133	pyrroloquinoline quinone binding
HOO69_04590	COG0456	acetyltransferase
HOO69_04600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO69_04600	COG0072	phenylalanine-tRNA ligase activity
HOO69_04610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOO69_04625	COG2176	DNA-directed DNA polymerase activity
HOO69_04630	COG0517	IMP dehydrogenase activity
HOO69_04635	COG2186	Transcriptional regulator
HOO69_04640	COG2186	Transcriptional regulator
HOO69_04665	COG1917	Cupin 2, conserved barrel domain protein
HOO69_04670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOO69_04675	COG0800	Aldolase
HOO69_04680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOO69_04685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HOO69_04695	COG0072	phenylalanine-tRNA ligase activity
HOO69_04695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO69_04700	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOO69_04705	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOO69_04710	COG1129	ABC transporter
HOO69_04720	COG2390	Transcriptional regulator
HOO69_04725	COG0667	Aldo Keto reductase
HOO69_04730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HOO69_04745	COG1454	alcohol dehydrogenase
HOO69_04760	COG1414	Transcriptional regulator
HOO69_04765	COG1414	Transcriptional regulator
HOO69_04770	COG3386	PFAM SMP-30 Gluconolaconase
HOO69_04785	COG1741	Belongs to the pirin family
HOO69_04795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_04795	COG1263	PTS System
HOO69_04800	COG1609	Transcriptional regulator
HOO69_04805	COG1621	beta-fructofuranosidase activity
HOO69_04810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOO69_04830	COG0583	DNA-binding transcription factor activity
HOO69_04850	COG1335	isochorismatase
HOO69_04865	COG0346	lactoylglutathione lyase activity
HOO69_04870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO69_04870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO69_04910	COG1605	Chorismate mutase
HOO69_04915	COG2824	Alkylphosphonate utilization operon protein PhnA
HOO69_04920	COG0789	Transcriptional regulator
HOO69_04925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HOO69_04935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HOO69_04940	COG1280	lysine exporter protein (LysE YggA)
HOO69_05010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HOO69_05015	COG1280	lysine exporter protein (LysE YggA)
HOO69_05030	COG1115	amino acid carrier protein
HOO69_05060	COG2195	Cleaves the N-terminal amino acid of tripeptides
HOO69_05070	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HOO69_05080	COG0625	glutathione transferase activity
HOO69_05100	COG2885	chlorophyll binding
HOO69_05115	COG0277	FAD linked oxidase domain protein
HOO69_05115	COG0247	lactate metabolic process
HOO69_05130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HOO69_05135	COG2986	histidine ammonia-lyase
HOO69_05140	COG0010	Belongs to the arginase family
HOO69_05145	COG1228	amidohydrolase
HOO69_05150	COG2188	Transcriptional regulator
HOO69_05155	COG4326	sporulation control protein
HOO69_05185	COG0295	cytidine deaminase activity
HOO69_05190	COG1346	cytolysis
HOO69_05195	COG1380	Effector of murein hydrolase LrgA
HOO69_05200	COG2925	Exonuclease
HOO69_05240	COG0702	epimerase
HOO69_05245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HOO69_05255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HOO69_05280	COG4139	cobalamin transport
HOO69_05295	COG2203	Gaf domain
HOO69_05295	COG2199	diguanylate cyclase activity
HOO69_05310	COG0583	DNA-binding transcription factor activity
HOO69_05315	COG1119	ATPase activity
HOO69_05330	COG1451	nucleotide metabolic process
HOO69_05345	COG3063	Type IV pilus biogenesis stability protein PilW
HOO69_05350	COG2267	carboxylic ester hydrolase activity
HOO69_05385	COG2095	MarC family integral membrane protein
HOO69_05400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO69_05430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HOO69_05535	COG3501	Rhs element vgr protein
HOO69_05555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HOO69_05560	COG0372	Belongs to the citrate synthase family
HOO69_05570	COG2828	Protein conserved in bacteria
HOO69_05595	COG0561	phosphatase activity
HOO69_05600	COG0602	queuosine metabolic process
HOO69_05610	COG3706	GGDEF domain
HOO69_05640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HOO69_05645	COG0840	transmembrane signaling receptor activity
HOO69_05650	COG1254	Belongs to the acylphosphatase family
HOO69_05655	COG2920	part of a sulfur-relay system
HOO69_05660	COG0670	Belongs to the BI1 family
HOO69_05665	COG1126	abc transporter atp-binding protein
HOO69_05670	COG0765	amino acid transport
HOO69_05675	COG4597	amino acid ABC transporter
HOO69_05680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_05690	COG1666	GTP binding
HOO69_05695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HOO69_05720	COG3008	intermembrane lipid transfer
HOO69_05725	COG2995	paraquat-inducible protein a
HOO69_05730	COG1132	(ABC) transporter
HOO69_05735	COG1956	GAF domain-containing protein
HOO69_05740	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HOO69_05755	COG0308	aminopeptidase N
HOO69_05770	COG0167	dihydroorotate dehydrogenase activity
HOO69_05780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HOO69_05780	COG0116	Belongs to the methyltransferase superfamily
HOO69_05790	COG0488	(ABC) transporter
HOO69_05805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HOO69_05810	COG1067	ATP-dependent peptidase activity
HOO69_05815	COG3120	sequence-specific DNA binding
HOO69_05840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HOO69_05845	COG2226	methyltransferase
HOO69_05950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOO69_06000	COG3278	Belongs to the heme-copper respiratory oxidase family
HOO69_06015	COG2010	Cytochrome c
HOO69_06025	COG2217	Heavy metal translocating P-type atpase
HOO69_06040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOO69_06045	COG0589	response to stress
HOO69_06050	COG0037	tRNA processing
HOO69_06055	COG0534	Mate efflux family protein
HOO69_06075	COG3842	ATPase activity
HOO69_06085	COG1177	transmembrane transport
HOO69_06090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HOO69_06095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HOO69_06100	COG2199	diguanylate cyclase activity
HOO69_06105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HOO69_06110	COG0004	ammonium transporteR
HOO69_06125	COG0437	4 iron, 4 sulfur cluster binding
HOO69_06130	COG3383	formate dehydrogenase (NAD+) activity
HOO69_06130	COG0243	molybdopterin cofactor binding
HOO69_06160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HOO69_06170	COG3040	lipid binding
HOO69_06205	COG2026	Addiction module toxin, RelE StbE family
HOO69_06235	COG2801	Transposase and inactivated derivatives
HOO69_06250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO69_06250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO69_06270	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_06295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO69_06295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO69_06375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO69_06375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOO69_06430	COG0488	(ABC) transporter
HOO69_06440	COG4191	Histidine kinase
HOO69_06445	COG2204	response regulator
HOO69_06455	COG4662	Binding-protein-dependent transport system inner membrane component
HOO69_06460	COG3842	ATPase activity
HOO69_06465	COG0746	molybdenum cofactor guanylyltransferase activity
HOO69_06470	COG0303	'Molybdopterin
HOO69_06480	COG1940	carbohydrate kinase activity
HOO69_06495	COG0840	transmembrane signaling receptor activity
HOO69_06500	COG0791	NLP P60 protein
HOO69_06520	COG0307	riboflavin synthase, alpha
HOO69_06525	COG0534	Mate efflux family protein
HOO69_06540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HOO69_06540	COG2885	chlorophyll binding
HOO69_06575	COG0438	transferase activity, transferring glycosyl groups
HOO69_06595	COG0110	maltose O-acetyltransferase activity
HOO69_06610	COG0438	transferase activity, transferring glycosyl groups
HOO69_06620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HOO69_06635	COG2205	protein histidine kinase activity
HOO69_06640	COG0745	RESPONSE REGULATOR receiver
HOO69_06665	COG3033	Beta-eliminating lyase
HOO69_06680	COG0745	RESPONSE REGULATOR receiver
HOO69_06685	COG0814	amino acid
HOO69_06690	COG1475	DNA binding
HOO69_06695	COG3969	phosphoadenosine phosphosulfate
HOO69_06740	COG2116	formate transmembrane transporter activity
HOO69_06750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HOO69_06755	COG0840	transmembrane signaling receptor activity
HOO69_06790	COG4565	transcriptional regulatory protein
HOO69_06795	COG3290	protein histidine kinase activity
HOO69_06810	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HOO69_06815	COG0848	biopolymer transport protein
HOO69_06820	COG0811	peptide transport
HOO69_06825	COG0811	peptide transport
HOO69_06845	COG0745	RESPONSE REGULATOR receiver
HOO69_06855	COG0039	L-malate dehydrogenase activity
HOO69_06865	COG0584	glycerophosphoryl diester phosphodiesterase
HOO69_06875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HOO69_06895	COG0583	DNA-binding transcription factor activity
HOO69_06900	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HOO69_06905	COG1328	CTP reductase activity
HOO69_06910	COG0840	transmembrane signaling receptor activity
HOO69_06925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HOO69_06935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO69_06970	COG0019	diaminopimelate decarboxylase activity
HOO69_07015	COG4181	ATPase activity
HOO69_07020	COG0534	Mate efflux family protein
HOO69_07025	COG0702	epimerase
HOO69_07035	COG2814	Major facilitator Superfamily
HOO69_07045	COG1061	Type III restriction enzyme res subunit
HOO69_07060	COG0642	Histidine kinase
HOO69_07075	COG3710	Transcriptional regulator
HOO69_07080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO69_07085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO69_07105	COG4589	Belongs to the CDS family
HOO69_07130	COG3501	Rhs element vgr protein
HOO69_07140	COG0463	Glycosyl transferase, family 2
HOO69_07150	COG0109	protoheme IX farnesyltransferase activity
HOO69_07155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HOO69_07160	COG1845	cytochrome c oxidase, subunit III
HOO69_07165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HOO69_07170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HOO69_07185	COG0583	DNA-binding transcription factor activity
HOO69_07190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HOO69_07205	COG0523	cobalamin synthesis protein
HOO69_07220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOO69_07225	COG1780	Probably involved in ribonucleotide reductase function
HOO69_07235	COG0316	Belongs to the HesB IscA family
HOO69_07240	COG0719	Fe-S assembly protein
HOO69_07245	COG0396	ATPase activity
HOO69_07250	COG0719	Fe-S assembly protein
HOO69_07265	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HOO69_07300	COG1858	cytochrome C peroxidase
HOO69_07330	COG3501	Rhs element vgr protein
HOO69_07340	COG2962	Rard protein
HOO69_07345	COG0531	amino acid
HOO69_07355	COG4667	esterase of the alpha-beta hydrolase superfamily
HOO69_07390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HOO69_07405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HOO69_07410	COG3108	Peptidase M15
HOO69_07415	COG2989	Protein conserved in bacteria
HOO69_07440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HOO69_07450	COG3706	GGDEF domain
HOO69_07465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO69_07480	COG3106	COG3106 Predicted ATPase
HOO69_07495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOO69_07500	COG0784	Response regulator, receiver
HOO69_07500	COG2205	protein histidine kinase activity
HOO69_07510	COG0494	nUDIX hydrolase
HOO69_07515	COG0814	amino acid
HOO69_07520	COG1760	l-serine dehydratase
HOO69_07530	COG2356	endonuclease I
HOO69_07535	COG0814	amino acid
HOO69_07545	COG0659	secondary active sulfate transmembrane transporter activity
HOO69_07555	COG0840	transmembrane signaling receptor activity
HOO69_07560	COG0017	Asparaginyl-tRNA synthetase
HOO69_07575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOO69_07585	COG3437	response regulator, receiver
HOO69_07585	COG2770	Histidine kinase
HOO69_07590	COG1448	Aminotransferase
HOO69_07610	COG1643	Atp-dependent helicase
HOO69_07615	COG0281	malic enzyme
HOO69_07625	COG2949	membrane
HOO69_07630	COG3706	GGDEF domain
HOO69_07640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HOO69_07650	COG0492	ferredoxin-NADP+ reductase activity
HOO69_07655	COG4988	ABC transporter
HOO69_07660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HOO69_07665	COG5001	Diguanylate cyclase
HOO69_07665	COG4251	negative regulation of phosphorylation
HOO69_07665	COG2203	Gaf domain
HOO69_07665	COG3706	GGDEF domain
HOO69_07680	COG1187	pseudouridine synthase activity
HOO69_07685	COG0009	L-threonylcarbamoyladenylate synthase
HOO69_07690	COG0613	PHP domain protein
HOO69_07700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOO69_07705	COG0512	Glutamine amidotransferase of anthranilate synthase
HOO69_07710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOO69_07715	COG0134	indole-3-glycerol-phosphate synthase activity
HOO69_07715	COG0135	phosphoribosylanthranilate isomerase activity
HOO69_07725	COG0159	tryptophan synthase activity
HOO69_07730	COG1301	dicarboxylic acid transport
HOO69_07750	COG1643	Atp-dependent helicase
HOO69_07780	COG3706	GGDEF domain
HOO69_07790	COG0443	Heat shock 70 kDa protein
HOO69_07795	COG0443	Heat shock 70 kDa protein
HOO69_07820	COG0457	Tetratricopeptide repeat
HOO69_07890	COG4790	Type iii secretion
HOO69_07895	COG4794	Type iii secretion
HOO69_07900	COG4791	protein targeting
HOO69_07905	COG4792	protein secretion
HOO69_07940	COG4669	(LipO)protein
HOO69_07975	COG1450	Type ii and iii secretion system protein
HOO69_08040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HOO69_08050	COG0673	inositol 2-dehydrogenase activity
HOO69_08060	COG0583	DNA-binding transcription factor activity
HOO69_08070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO69_08080	COG1764	response to oxidative stress
HOO69_08085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HOO69_08110	COG3300	MHYT domain
HOO69_08110	COG5001	Diguanylate cyclase
HOO69_08115	COG1032	radical SAM domain protein
HOO69_08120	COG5001	Diguanylate cyclase
HOO69_08120	COG3300	MHYT domain
HOO69_08125	COG2201	protein-glutamate methylesterase activity
HOO69_08130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HOO69_08140	COG0835	chemotaxis
HOO69_08145	COG0840	transmembrane signaling receptor activity
HOO69_08150	COG0643	Histidine kinase
HOO69_08150	COG2198	Histidine kinase
HOO69_08160	COG0745	RESPONSE REGULATOR receiver
HOO69_08170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HOO69_08180	COG4191	Histidine kinase
HOO69_08180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_08195	COG3070	regulator of competence-specific genes
HOO69_08205	COG2431	L-lysine efflux transmembrane transporter activity
HOO69_08215	COG0076	glutamate decarboxylase activity
HOO69_08220	COG1737	Transcriptional regulator
HOO69_08225	COG1454	alcohol dehydrogenase
HOO69_08225	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_08230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HOO69_08240	COG4160	amino acid transport
HOO69_08265	COG1882	Formate acetyltransferase
HOO69_08280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HOO69_08305	COG2766	serine protein kinase
HOO69_08310	COG2718	Belongs to the UPF0229 family
HOO69_08315	COG2719	SpoVR family
HOO69_08320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HOO69_08335	COG1132	(ABC) transporter
HOO69_08340	COG2333	competence protein COMEC
HOO69_08340	COG0658	competence protein
HOO69_08365	COG4591	ABC-type transport system involved in lipoprotein release permease component
HOO69_08370	COG1136	(ABC) transporter
HOO69_08375	COG4591	ABC-type transport system involved in lipoprotein release permease component
HOO69_08385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HOO69_08395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO69_08400	COG1252	NADH dehydrogenase
HOO69_08405	COG3150	esterase
HOO69_08430	COG0537	adenosine 5'-monophosphoramidase activity
HOO69_08445	COG2186	Transcriptional regulator
HOO69_08450	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HOO69_08460	COG1674	ftsk spoiiie
HOO69_08465	COG1522	sequence-specific DNA binding
HOO69_08470	COG0686	Belongs to the AlaDH PNT family
HOO69_08475	COG3092	negative regulation of chromosome organization
HOO69_08480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOO69_08485	COG0280	phosphate acetyltransferase
HOO69_08485	COG0857	belongs to the CobB CobQ family
HOO69_08490	COG3706	GGDEF domain
HOO69_08495	COG0435	Glutathione S-transferase
HOO69_08505	COG0444	Belongs to the ABC transporter superfamily
HOO69_08510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOO69_08515	COG0601	transmembrane transport
HOO69_08530	COG2067	long-chain fatty acid transport protein
HOO69_08545	COG1136	(ABC) transporter
HOO69_08545	COG0577	efflux transmembrane transporter activity
HOO69_08550	COG0577	efflux transmembrane transporter activity
HOO69_08550	COG1136	(ABC) transporter
HOO69_08555	COG0577	efflux transmembrane transporter activity
HOO69_08565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO69_08575	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO69_08615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HOO69_08625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HOO69_08650	COG2199	diguanylate cyclase activity
HOO69_08665	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HOO69_08670	COG1946	Acyl-CoA thioesterase
HOO69_08680	COG1522	sequence-specific DNA binding
HOO69_08685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HOO69_08705	COG0477	Major facilitator Superfamily
HOO69_08710	COG2855	membrane
HOO69_08725	COG1263	PTS System
HOO69_08725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_08725	COG2190	(PTS) system
HOO69_08745	COG0596	Alpha beta hydrolase
HOO69_08750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HOO69_08755	COG1169	isochorismate synthase
HOO69_08760	COG0436	Aminotransferase
HOO69_08765	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HOO69_08785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HOO69_08790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HOO69_08805	COG0513	Belongs to the DEAD box helicase family
HOO69_08840	COG0616	signal peptide processing
HOO69_08845	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_08865	COG0835	chemotaxis
HOO69_08865	COG0784	Response regulator, receiver
HOO69_08870	COG1940	carbohydrate kinase activity
HOO69_08875	COG0469	pyruvate kinase activity
HOO69_08880	COG4667	esterase of the alpha-beta hydrolase superfamily
HOO69_08900	COG1263	PTS System
HOO69_08900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_08905	COG0084	hydrolase, TatD family'
HOO69_08910	COG0470	DNA polymerase III
HOO69_08920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HOO69_08950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOO69_08965	COG1399	metal-binding, possibly nucleic acid-binding protein
HOO69_08970	COG0424	maF-like protein
HOO69_08975	COG0564	pseudouridine synthase activity
HOO69_08980	COG1530	ribonuclease E activity
HOO69_08985	COG0659	secondary active sulfate transmembrane transporter activity
HOO69_08990	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HOO69_08995	COG0318	PFAM AMP-dependent synthetase and ligase
HOO69_09000	COG0596	Alpha beta hydrolase
HOO69_09005	COG3065	identical protein binding
HOO69_09015	COG1214	PFAM Peptidase M22, glycoprotease
HOO69_09020	COG1199	ATP-dependent helicase activity
HOO69_09030	COG0788	formyltetrahydrofolate deformylase activity
HOO69_09035	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOO69_09035	COG1902	pentaerythritol trinitrate reductase activity
HOO69_09040	COG0616	signal peptide processing
HOO69_09055	COG0477	Major facilitator Superfamily
HOO69_09060	COG0252	asparaginase activity
HOO69_09070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HOO69_09075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HOO69_09085	COG0653	protein targeting
HOO69_09095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HOO69_09100	COG2199	diguanylate cyclase activity
HOO69_09100	COG2203	Gaf domain
HOO69_09110	COG4120	Belongs to the binding-protein-dependent transport system permease family
HOO69_09125	COG0583	DNA-binding transcription factor activity
HOO69_09150	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HOO69_09155	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HOO69_09165	COG0539	negative regulation of cytoplasmic translation
HOO69_09170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HOO69_09175	COG1555	photosystem II stabilization
HOO69_09180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HOO69_09185	COG0776	regulation of translation
HOO69_09190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HOO69_09205	COG0544	peptidyl-prolyl cis-trans isomerase activity
HOO69_09215	COG2204	response regulator
HOO69_09220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HOO69_09225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HOO69_09230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HOO69_09235	COG3842	ATPase activity
HOO69_09240	COG0395	ABC-type sugar transport system, permease component
HOO69_09245	COG1175	transmembrane transport
HOO69_09260	COG0745	RESPONSE REGULATOR receiver
HOO69_09270	COG5002	protein histidine kinase activity
HOO69_09270	COG2205	protein histidine kinase activity
HOO69_09270	COG0784	Response regulator, receiver
HOO69_09275	COG0840	transmembrane signaling receptor activity
HOO69_09300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HOO69_09310	COG2951	lytic endotransglycosylase activity
HOO69_09320	COG0850	regulation of cytokinetic process
HOO69_09325	COG2894	cell division
HOO69_09330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HOO69_09340	COG1454	alcohol dehydrogenase
HOO69_09340	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_09345	COG2095	MarC family integral membrane protein
HOO69_09350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOO69_09360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HOO69_09365	COG1757	Na H antiporter
HOO69_09405	COG0494	nUDIX hydrolase
HOO69_09410	COG0123	including yeast histone deacetylase and acetoin utilization protein
HOO69_09415	COG4580	involved in the transport of maltose and maltodextrins
HOO69_09420	COG1609	Transcriptional regulator
HOO69_09435	COG0395	ABC-type sugar transport system, permease component
HOO69_09440	COG2723	6-phospho-beta-galactosidase activity
HOO69_09445	COG3842	ATPase activity
HOO69_09450	COG1609	Transcriptional regulator
HOO69_09475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HOO69_09480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HOO69_09500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOO69_09510	COG0840	transmembrane signaling receptor activity
HOO69_09515	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HOO69_09530	COG0572	uridine kinase
HOO69_09535	COG0489	protein tyrosine kinase activity
HOO69_09570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HOO69_09570	COG0617	tRNA 3'-terminal CCA addition
HOO69_09570	COG0517	IMP dehydrogenase activity
HOO69_09580	COG3706	GGDEF domain
HOO69_09585	COG0314	molybdopterin synthase activity
HOO69_09590	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HOO69_09595	COG0315	cyclic pyranopterin monophosphate synthase activity
HOO69_09600	COG0521	Mo-molybdopterin cofactor biosynthetic process
HOO69_09610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HOO69_09615	COG2198	Histidine kinase
HOO69_09620	COG2204	response regulator
HOO69_09625	COG0556	nucleotide-excision repair
HOO69_09660	COG3842	ATPase activity
HOO69_09670	COG4657	Part of a membrane complex involved in electron transport
HOO69_09680	COG4656	Part of a membrane complex involved in electron transport
HOO69_09690	COG4659	FMN binding
HOO69_09695	COG4660	Part of a membrane complex involved in electron transport
HOO69_09700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HOO69_09705	COG0346	lactoylglutathione lyase activity
HOO69_09725	COG2056	Na+-H+ antiporter family
HOO69_09735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOO69_09740	COG2716	regulation of RNA biosynthetic process
HOO69_09745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HOO69_09765	COG4783	chaperone-mediated protein folding
HOO69_09770	COG1393	Belongs to the ArsC family
HOO69_09790	COG2233	PERMEase
HOO69_09795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HOO69_09805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HOO69_09810	COG2912	Transglutaminase-like superfamily
HOO69_09820	COG2890	protein-(glutamine-N5) methyltransferase activity
HOO69_09835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HOO69_09845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOO69_09970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HOO69_09980	COG1705	Flagellar rod assembly protein muramidase FlgJ
HOO69_09980	COG3951	Flagellar rod assembly protein muramidase FlgJ
HOO69_09990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HOO69_10000	COG4787	bacterial-type flagellum-dependent cell motility
HOO69_10005	COG1749	Flagellar hook protein flgE
HOO69_10020	COG1815	bacterial-type flagellum-dependent cell motility
HOO69_10025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HOO69_10030	COG0835	chemotaxis
HOO69_10030	COG0784	Response regulator, receiver
HOO69_10040	COG2747	anti-sigma28 factor FlgM
HOO69_10110	COG0582	viral genome integration into host DNA
HOO69_10125	COG2885	chlorophyll binding
HOO69_10145	COG2217	Heavy metal translocating P-type atpase
HOO69_10145	COG2608	mercury ion transmembrane transporter activity
HOO69_10170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HOO69_10185	COG3710	Transcriptional regulator
HOO69_10205	COG0622	Phosphoesterase
HOO69_10230	COG1090	epimerase
HOO69_10235	COG0300	oxidoreductase activity
HOO69_10240	COG3118	belongs to the thioredoxin family
HOO69_10245	COG0330	HflC and HflK could
HOO69_10280	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HOO69_10285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HOO69_10290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_10295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HOO69_10300	COG2190	(PTS) system
HOO69_10305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOO69_10310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOO69_10315	COG1702	phosphate starvation-inducible protein PhoH
HOO69_10320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HOO69_10325	COG4535	Mg2 and Co2 transporter CorC
HOO69_10330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HOO69_10335	COG2888	peptidyl-tyrosine sulfation
HOO69_10340	COG0495	leucyl-tRNA aminoacylation
HOO69_10345	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HOO69_10350	COG1466	dna polymerase III delta subunit
HOO69_10355	COG0799	negative regulation of ribosome biogenesis
HOO69_10360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HOO69_10370	COG0772	Belongs to the SEDS family
HOO69_10375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HOO69_10380	COG1686	Belongs to the peptidase S11 family
HOO69_10385	COG2921	Belongs to the UPF0250 family
HOO69_10405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOO69_10415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO69_10445	COG0366	Alpha amylase catalytic
HOO69_10450	COG1263	PTS System
HOO69_10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_10465	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HOO69_10475	COG2011	ABC-type metal ion transport system permease component
HOO69_10480	COG1464	Belongs to the NlpA lipoprotein family
HOO69_10490	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HOO69_10505	COG1720	tRNA m6t6A37 methyltransferase activity
HOO69_10515	COG0121	glutamine amidotransferase
HOO69_10520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HOO69_10525	COG1960	acyl-CoA dehydrogenase activity
HOO69_10540	COG0328	RNA-DNA hybrid ribonuclease activity
HOO69_10545	COG2226	methyltransferase
HOO69_10550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HOO69_10555	COG1388	LysM domain
HOO69_10555	COG0741	lytic transglycosylase activity
HOO69_10565	COG3021	interspecies interaction between organisms
HOO69_10570	COG0347	Belongs to the P(II) protein family
HOO69_10590	COG0587	DNA-directed DNA polymerase activity
HOO69_10615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HOO69_10620	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HOO69_10625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO69_10630	COG0750	zinc metalloprotease
HOO69_10635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HOO69_10640	COG0575	Belongs to the CDS family
HOO69_10645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HOO69_10650	COG0233	cytoplasmic translational termination
HOO69_10665	COG0052	Belongs to the universal ribosomal protein uS2 family
HOO69_10670	COG0024	Methionine aminopeptidase
HOO69_10685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HOO69_10715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO69_10715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HOO69_10720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HOO69_10725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HOO69_10730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HOO69_10750	COG2252	PERMEase
HOO69_10755	COG2195	Cleaves the N-terminal amino acid of tripeptides
HOO69_10760	COG4067	protein conserved in archaea
HOO69_10760	COG0189	ligase activity
HOO69_10765	COG0189	ligase activity
HOO69_10775	COG0733	neurotransmitter:sodium symporter activity
HOO69_10795	COG0514	ATP-dependent DNA helicase (RecQ)
HOO69_10800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HOO69_10810	COG2991	Protein conserved in bacteria
HOO69_10815	COG1477	protein flavinylation
HOO69_10820	COG2871	sodium ion transport
HOO69_10825	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HOO69_10830	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HOO69_10840	COG1805	sodium ion transport
HOO69_10845	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HOO69_10850	COG0271	Belongs to the BolA IbaG family
HOO69_10870	COG2211	Major facilitator Superfamily
HOO69_10880	COG1595	DNA-templated transcription, initiation
HOO69_10895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HOO69_10900	COG0693	protein deglycase activity
HOO69_10910	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HOO69_10920	COG0560	Phosphoserine phosphatase
HOO69_10930	COG0813	purine-nucleoside phosphorylase activity
HOO69_10935	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HOO69_10940	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HOO69_10955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HOO69_10960	COG0084	hydrolase, TatD family'
HOO69_10970	COG3022	response to hydroperoxide
HOO69_10975	COG1115	amino acid carrier protein
HOO69_10990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HOO69_10995	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HOO69_11000	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HOO69_11010	COG0730	response to heat
HOO69_11015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HOO69_11020	COG0505	Belongs to the CarA family
HOO69_11030	COG0494	nUDIX hydrolase
HOO69_11050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HOO69_11055	COG0849	cell division
HOO69_11060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HOO69_11070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HOO69_11075	COG0772	Belongs to the SEDS family
HOO69_11080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HOO69_11090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HOO69_11100	COG0768	penicillin binding
HOO69_11105	COG3116	cell division
HOO69_11120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HOO69_11125	COG3107	peptidoglycan biosynthetic process
HOO69_11130	COG0792	nuclease activity
HOO69_11135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HOO69_11145	COG2969	positive regulation of protein catabolic process
HOO69_11150	COG0625	glutathione transferase activity
HOO69_11155	COG2857	Cytochrome c1
HOO69_11160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HOO69_11165	COG0723	plastoquinol--plastocyanin reductase activity
HOO69_11180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HOO69_11185	COG3105	Protein conserved in bacteria
HOO69_11190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HOO69_11195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HOO69_11210	COG3150	esterase
HOO69_11220	COG3151	Protein conserved in bacteria
HOO69_11225	COG0494	nUDIX hydrolase
HOO69_11230	COG1538	Outer membrane efflux protein
HOO69_11240	COG0784	Response regulator, receiver
HOO69_11240	COG2198	Histidine kinase
HOO69_11240	COG5002	protein histidine kinase activity
HOO69_11245	COG4251	negative regulation of phosphorylation
HOO69_11245	COG3706	GGDEF domain
HOO69_11245	COG5001	Diguanylate cyclase
HOO69_11245	COG2203	Gaf domain
HOO69_11250	COG1242	4 iron, 4 sulfur cluster binding
HOO69_11255	COG0070	glutamate synthase
HOO69_11255	COG0067	glutamate synthase
HOO69_11255	COG0069	glutamate synthase activity
HOO69_11265	COG0070	glutamate synthase
HOO69_11265	COG0069	glutamate synthase activity
HOO69_11265	COG0067	glutamate synthase
HOO69_11270	COG0493	'glutamate synthase
HOO69_11295	COG0195	Participates in both transcription termination and antitermination
HOO69_11300	COG0779	Required for maturation of 30S ribosomal subunits
HOO69_11315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HOO69_11320	COG3153	acetyltransferase
HOO69_11325	COG3154	lipid carrier protein
HOO69_11335	COG0826	peptidase U32
HOO69_11340	COG0826	peptidase U32
HOO69_11370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HOO69_11380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HOO69_11385	COG2860	membrane
HOO69_11390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HOO69_11410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HOO69_11420	COG0745	RESPONSE REGULATOR receiver
HOO69_11430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HOO69_11440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOO69_11445	COG3025	triphosphatase activity
HOO69_11450	COG1392	Phosphate transport regulator
HOO69_11460	COG4991	sh3 domain protein
HOO69_11480	COG0148	phosphopyruvate hydratase activity
HOO69_11490	COG3956	TIGRFAM MazG family protein
HOO69_11495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOO69_11505	COG2205	protein histidine kinase activity
HOO69_11505	COG3437	response regulator, receiver
HOO69_11505	COG3850	Histidine kinase
HOO69_11505	COG4999	Histidine kinase
HOO69_11525	COG0736	holo-[acyl-carrier-protein] synthase activity
HOO69_11530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HOO69_11535	COG1381	Involved in DNA repair and RecF pathway recombination
HOO69_11540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HOO69_11560	COG3086	response to oxidative stress
HOO69_11565	COG3026	antisigma factor binding
HOO69_11575	COG1595	DNA-templated transcription, initiation
HOO69_11580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HOO69_11590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HOO69_11610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOO69_11615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOO69_11625	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HOO69_11635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HOO69_11640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HOO69_11645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HOO69_11655	COG0028	Belongs to the TPP enzyme family
HOO69_11660	COG1022	Amp-dependent synthetase and ligase
HOO69_11665	COG0583	DNA-binding transcription factor activity
HOO69_11680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOO69_11685	COG0473	3-isopropylmalate dehydrogenase activity
HOO69_11750	COG3437	response regulator, receiver
HOO69_11770	COG1854	S-ribosylhomocysteine lyase activity
HOO69_11780	COG2918	glutathione biosynthetic process
HOO69_11785	COG0612	Peptidase, M16
HOO69_11790	COG1238	metal cluster binding
HOO69_11800	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HOO69_11805	COG0511	ligase activity, forming carbon-carbon bonds
HOO69_11805	COG5016	pyruvate
HOO69_11810	COG3630	sodium ion export across plasma membrane
HOO69_11860	COG0527	aspartate kinase activity
HOO69_11875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HOO69_11880	COG1546	Belongs to the CinA family
HOO69_11885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HOO69_11890	COG0795	lipopolysaccharide-transporting ATPase activity
HOO69_11895	COG0795	lipopolysaccharide-transporting ATPase activity
HOO69_11905	COG2927	DNA polymerase III (CHI subunit)
HOO69_11910	COG0525	valine-tRNA ligase activity
HOO69_11920	COG4269	membrane
HOO69_11930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOO69_11935	COG0564	pseudouridine synthase activity
HOO69_11940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HOO69_11945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HOO69_11960	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HOO69_11965	COG0251	oxidation-reduction process
HOO69_11975	COG0039	L-malate dehydrogenase activity
HOO69_11980	COG1438	arginine binding
HOO69_11985	COG2358	TRAP transporter, solute receptor (TAXI family
HOO69_11995	COG0589	response to stress
HOO69_12015	COG2235	arginine
HOO69_12020	COG0312	modulator of DNA gyrase
HOO69_12025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOO69_12030	COG3164	Protein of unknown function
HOO69_12035	COG1530	ribonuclease E activity
HOO69_12040	COG0424	maF-like protein
HOO69_12045	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HOO69_12050	COG1792	Involved in formation and maintenance of cell shape
HOO69_12055	COG1077	Cell shape determining protein MreB Mrl
HOO69_12085	COG4969	Belongs to the N-Me-Phe pilin family
HOO69_12100	COG1459	type II secretion system
HOO69_12105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HOO69_12140	COG2200	EAL domain
HOO69_12140	COG2199	diguanylate cyclase activity
HOO69_12145	COG0629	single-stranded DNA binding
HOO69_12150	COG2197	response regulator
HOO69_12160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HOO69_12170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HOO69_12175	COG0527	aspartate kinase activity
HOO69_12185	COG3028	Belongs to the UPF0307 family
HOO69_12190	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HOO69_12195	COG1178	ABC-type Fe3 transport system permease component
HOO69_12200	COG4143	(ABC) transporter
HOO69_12205	COG0163	prenyltransferase activity
HOO69_12210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HOO69_12225	COG2105	PFAM AIG2 family protein
HOO69_12230	COG2911	Protein conserved in bacteria
HOO69_12235	COG0729	surface antigen
HOO69_12240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOO69_12245	COG0745	RESPONSE REGULATOR receiver
HOO69_12245	COG4566	intracellular signal transduction
HOO69_12250	COG0004	ammonium transporteR
HOO69_12260	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HOO69_12275	COG1136	(ABC) transporter
HOO69_12300	COG0432	Pfam Uncharacterised protein family UPF0047
HOO69_12315	COG0251	oxidation-reduction process
HOO69_12325	COG2964	Protein conserved in bacteria
HOO69_12335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HOO69_12360	COG2965	DNA replication, synthesis of RNA primer
HOO69_12365	COG0360	Binds together with S18 to 16S ribosomal RNA
HOO69_12370	COG2194	sulfuric ester hydrolase activity
HOO69_12375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HOO69_12385	COG2906	2 iron, 2 sulfur cluster binding
HOO69_12395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HOO69_12410	COG2168	tRNA wobble position uridine thiolation
HOO69_12415	COG2923	Belongs to the DsrF TusC family
HOO69_12420	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HOO69_12425	COG2964	Protein conserved in bacteria
HOO69_12430	COG0545	Peptidyl-prolyl cis-trans isomerase
HOO69_12440	COG2900	Belongs to the SlyX family
HOO69_12450	COG0330	HflC and HflK could
HOO69_12455	COG0330	HflC and HflK could
HOO69_12460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HOO69_12475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HOO69_12485	COG0802	atpase or kinase
HOO69_12490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HOO69_12550	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HOO69_12555	COG1162	GTPase activity
HOO69_12565	COG0471	metal ion transport
HOO69_12565	COG0490	domain, Protein
HOO69_12570	COG0840	transmembrane signaling receptor activity
HOO69_12585	COG4942	peptidase
HOO69_12610	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HOO69_12620	COG0085	RNA polymerase activity
HOO69_12630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HOO69_12645	COG0250	Participates in transcription elongation, termination and antitermination
HOO69_12650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HOO69_12680	COG1072	(Pantothenic acid kinase))
HOO69_12695	COG0149	triose-phosphate isomerase activity
HOO69_12700	COG0534	Mate efflux family protein
HOO69_12705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HOO69_12710	COG1575	Belongs to the MenA family. Type 1 subfamily
HOO69_12715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOO69_12720	COG1509	lysine 2,3-aminomutase activity
HOO69_12730	COG1285	pathogenesis
HOO69_12735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HOO69_12745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HOO69_12750	COG3678	ATP-independent chaperone mediated protein folding
HOO69_12755	COG0745	RESPONSE REGULATOR receiver
HOO69_12760	COG2205	protein histidine kinase activity
HOO69_12765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HOO69_12770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HOO69_12775	COG0180	Tryptophanyl-tRNA synthetase
HOO69_12780	COG0546	phosphoglycolate phosphatase activity
HOO69_12785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HOO69_12790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HOO69_12835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HOO69_12845	COG0678	peroxiredoxin activity
HOO69_12845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HOO69_12850	COG0251	oxidation-reduction process
HOO69_12860	COG0165	Argininosuccinate lyase
HOO69_12860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HOO69_12865	COG0137	argininosuccinate synthase activity
HOO69_12870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HOO69_12875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HOO69_12885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HOO69_12890	COG1695	Transcriptional regulator
HOO69_12895	COG1045	serine acetyltransferase
HOO69_12910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HOO69_12915	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HOO69_12920	COG1053	succinate dehydrogenase
HOO69_12925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HOO69_12940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HOO69_12960	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HOO69_12965	COG1609	Transcriptional regulator
HOO69_12970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HOO69_12980	COG0281	malic enzyme
HOO69_12990	COG0626	cystathionine gamma-synthase activity
HOO69_12995	COG0527	aspartate kinase activity
HOO69_12995	COG0460	homoserine dehydrogenase
HOO69_13010	COG1494	fructose-1,6-bisphosphatase
HOO69_13080	COG4206	TonB-dependent receptor
HOO69_13100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOO69_13110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HOO69_13115	COG0534	Mate efflux family protein
HOO69_13130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HOO69_13135	COG2937	Belongs to the GPAT DAPAT family
HOO69_13140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HOO69_13145	COG3161	chorismate lyase activity
HOO69_13150	COG1580	Controls the rotational direction of flagella during chemotaxis
HOO69_13155	COG0705	Rhomboid family
HOO69_13160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HOO69_13170	COG2177	Part of the ABC transporter FtsEX involved in
HOO69_13175	COG2884	Cell division ATP-binding protein ftsE
HOO69_13180	COG0552	protein localization to endoplasmic reticulum
HOO69_13185	COG0742	ribosomal rna small subunit methyltransferase
HOO69_13195	COG2095	MarC family integral membrane protein
HOO69_13235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HOO69_13240	COG0640	Transcriptional regulator
HOO69_13245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HOO69_13250	COG1280	lysine exporter protein (LysE YggA)
HOO69_13255	COG2267	carboxylic ester hydrolase activity
HOO69_13260	COG0561	phosphatase activity
HOO69_13280	COG2200	EAL domain
HOO69_13280	COG2199	diguanylate cyclase activity
HOO69_13280	COG3287	FIST C domain
HOO69_13285	COG1011	Hydrolase
HOO69_13290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HOO69_13300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HOO69_13305	COG0019	diaminopimelate decarboxylase activity
HOO69_13315	COG1965	Belongs to the frataxin family
HOO69_13320	COG3072	Adenylate cyclase
HOO69_13330	COG1587	Uroporphyrinogen-III synthase
HOO69_13335	COG2959	enzyme of heme biosynthesis
HOO69_13340	COG3071	HemY protein
HOO69_13390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HOO69_13405	COG3118	belongs to the thioredoxin family
HOO69_13415	COG0248	Ppx GppA phosphatase
HOO69_13420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HOO69_13430	COG0514	ATP-dependent DNA helicase (RecQ)
HOO69_13435	COG2962	Rard protein
HOO69_13445	COG1280	lysine exporter protein (LysE YggA)
HOO69_13450	COG0405	Gamma-glutamyltransferase
HOO69_13460	COG0210	DNA helicase
HOO69_13470	COG3220	belongs to the UPF0276 family
HOO69_13495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HOO69_13505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOO69_13525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOO69_13535	COG0747	negative chemotaxis
HOO69_13580	COG1309	transcriptional regulator
HOO69_13585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO69_13590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO69_13595	COG2960	long-chain fatty acid transporting porin activity
HOO69_13600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HOO69_13605	COG0583	DNA-binding transcription factor activity
HOO69_13610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HOO69_13635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HOO69_13640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOO69_13640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOO69_13655	COG0084	hydrolase, TatD family'
HOO69_13660	COG0805	protein transport
HOO69_13665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOO69_13685	COG2226	methyltransferase
HOO69_13690	COG1322	Protein conserved in bacteria
HOO69_13700	COG1639	'signal transduction protein
HOO69_13715	COG2081	HI0933 family
HOO69_13725	COG1528	Iron-storage protein
HOO69_13730	COG0589	response to stress
HOO69_13745	COG0742	ribosomal rna small subunit methyltransferase
HOO69_13750	COG5002	protein histidine kinase activity
HOO69_13750	COG5001	Diguanylate cyclase
HOO69_13755	COG1522	sequence-specific DNA binding
HOO69_13775	COG0006	proline dipeptidase activity
HOO69_13775	COG0006	proline dipeptidase activity
HOO69_13790	COG2104	thiamine diphosphate biosynthetic process
HOO69_13795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HOO69_13810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOO69_13815	COG2132	Multicopper oxidase
HOO69_13870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HOO69_13875	COG1739	Uncharacterized protein family UPF0029
HOO69_13885	COG0183	Belongs to the thiolase family
HOO69_13890	COG0583	DNA-binding transcription factor activity
HOO69_13895	COG2814	Major facilitator Superfamily
HOO69_13905	COG0765	amino acid transport
HOO69_13915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HOO69_13920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HOO69_13925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HOO69_13935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOO69_13940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HOO69_13955	COG3312	ion transport
HOO69_13960	COG1475	DNA binding
HOO69_13965	COG1192	Involved in chromosome partitioning
HOO69_13975	COG0445	tRNA wobble uridine modification
HOO69_13980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HOO69_13985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HOO69_13990	COG0706	membrane insertase activity
HOO69_14000	COG0594	ribonuclease P activity
HOO69_14010	COG1126	abc transporter atp-binding protein
HOO69_14030	COG0592	DNA-directed DNA polymerase activity
HOO69_14035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HOO69_14040	COG0187	DNA topoisomerase II activity
HOO69_14045	COG0071	Belongs to the small heat shock protein (HSP20) family
HOO69_14055	COG3977	Valine--pyruvate aminotransferase
HOO69_14060	COG0751	glycine-tRNA ligase activity
HOO69_14070	COG2119	membrane
HOO69_14080	COG0425	Belongs to the sulfur carrier protein TusA family
HOO69_14095	COG0604	alcohol dehydrogenase
HOO69_14105	COG0129	dihydroxy-acid dehydratase activity
HOO69_14110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HOO69_14115	COG3978	acetolactate synthase activity
HOO69_14135	COG0758	DNA mediated transformation
HOO69_14180	COG0204	Acyl-transferase
HOO69_14185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HOO69_14190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HOO69_14200	COG3084	Protein conserved in bacteria
HOO69_14210	COG4326	sporulation control protein
HOO69_14215	COG1272	protein, Hemolysin III
HOO69_14220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HOO69_14225	COG0569	domain protein
HOO69_14230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HOO69_14230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HOO69_14235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOO69_14240	COG0242	peptide deformylase activity
HOO69_14245	COG1652	LysM domain
HOO69_14250	COG0758	DNA mediated transformation
HOO69_14255	COG2922	Belongs to the Smg family
HOO69_14260	COG0551	DNA topoisomerase type I activity
HOO69_14265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HOO69_14270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HOO69_14275	COG0009	L-threonylcarbamoyladenylate synthase
HOO69_14280	COG0408	coproporphyrinogen oxidase activity
HOO69_14285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HOO69_14295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HOO69_14340	COG5001	Diguanylate cyclase
HOO69_14340	COG3300	MHYT domain
HOO69_14350	COG3852	Histidine kinase
HOO69_14360	COG0174	glutamine synthetase
HOO69_14390	COG1490	D-aminoacyl-tRNA deacylase activity
HOO69_14395	COG0456	acetyltransferase
HOO69_14405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HOO69_14410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HOO69_14415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HOO69_14420	COG3031	protein transport across the cell outer membrane
HOO69_14430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HOO69_14435	COG1459	type II secretion system
HOO69_14440	COG2165	general secretion pathway protein
HOO69_14445	COG2165	general secretion pathway protein
HOO69_14450	COG2165	general secretion pathway protein
HOO69_14455	COG4795	General secretion pathway protein
HOO69_14460	COG3156	type II secretion system protein K
HOO69_14465	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HOO69_14470	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HOO69_14480	COG2205	protein histidine kinase activity
HOO69_14485	COG0745	RESPONSE REGULATOR receiver
HOO69_14490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HOO69_14500	COG2183	response to ionizing radiation
HOO69_14525	COG0494	nUDIX hydrolase
HOO69_14530	COG1218	3'(2'),5'-bisphosphate nucleotidase
HOO69_14535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HOO69_14540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOO69_14545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOO69_14550	COG1758	RNA polymerase activity
HOO69_14555	COG0194	GDP metabolic process
HOO69_14560	COG2252	PERMEase
HOO69_14575	COG1561	YicC-like family, N-terminal region
HOO69_14580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HOO69_14590	COG1560	Kdo2-lipid A biosynthetic process
HOO69_14595	COG1560	Kdo2-lipid A biosynthetic process
HOO69_14600	COG1309	transcriptional regulator
HOO69_14605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HOO69_14610	COG2003	Belongs to the UPF0758 family
HOO69_14635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HOO69_14640	COG0859	PFAM glycosyl transferase family 9
HOO69_14645	COG0463	Glycosyl transferase, family 2
HOO69_14650	COG0859	PFAM glycosyl transferase family 9
HOO69_14655	COG3642	lipopolysaccharide core region biosynthetic process
HOO69_14685	COG1088	dTDP-glucose 4,6-dehydratase activity
HOO69_14690	COG1519	Transferase
HOO69_14700	COG0859	PFAM glycosyl transferase family 9
HOO69_14715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HOO69_14720	COG0673	inositol 2-dehydrogenase activity
HOO69_14725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HOO69_14745	COG1086	Polysaccharide biosynthesis protein
HOO69_14750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOO69_14755	COG1083	cytidylyl-transferase
HOO69_14765	COG2089	acid synthase
HOO69_14775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HOO69_14835	COG0438	transferase activity, transferring glycosyl groups
HOO69_14845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HOO69_14855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOO69_14860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HOO69_14860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HOO69_14865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HOO69_14895	COG0459	protein refolding
HOO69_14900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HOO69_14905	COG1573	uracil-dna glycosylase
HOO69_14920	COG1253	flavin adenine dinucleotide binding
HOO69_14935	COG0151	Belongs to the GarS family
HOO69_14945	COG0789	Transcriptional regulator
HOO69_14950	COG3706	GGDEF domain
HOO69_14955	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HOO69_14960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HOO69_14970	COG0439	Biotin carboxylase
HOO69_14975	COG0511	ligase activity, forming carbon-carbon bonds
HOO69_14980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HOO69_14985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HOO69_15000	COG2814	Major facilitator Superfamily
HOO69_15005	COG0784	Response regulator, receiver
HOO69_15005	COG2205	protein histidine kinase activity
HOO69_15015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOO69_15025	COG2095	MarC family integral membrane protein
HOO69_15035	COG4232	protein-disulfide reductase activity
HOO69_15040	COG1438	arginine binding
HOO69_15045	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HOO69_15050	COG0540	Belongs to the ATCase OTCase family
HOO69_15055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HOO69_15070	COG1288	antiporter activity
HOO69_15075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HOO69_15080	COG1027	Aspartate ammonia-lyase
HOO69_15100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HOO69_15120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOO69_15125	COG3954	Phosphoribulokinase
HOO69_15130	COG3089	Belongs to the UPF0270 family
HOO69_15135	COG0429	hydrolase of the alpha beta-hydrolase fold
HOO69_15145	COG0488	(ABC) transporter
HOO69_15150	COG2249	NAD(P)H dehydrogenase (quinone) activity
HOO69_15160	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HOO69_15165	COG1047	Peptidyl-prolyl cis-trans
HOO69_15170	COG1446	asparaginase
HOO69_15175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HOO69_15180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HOO69_15185	COG0402	S-adenosylhomocysteine deaminase activity
HOO69_15190	COG0557	exoribonuclease II activity
HOO69_15195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOO69_15205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HOO69_15210	COG0088	Forms part of the polypeptide exit tunnel
HOO69_15225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HOO69_15230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HOO69_15235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HOO69_15250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HOO69_15265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HOO69_15280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HOO69_15295	COG1841	ribosomal large subunit assembly
HOO69_15305	COG0201	protein transport
HOO69_15310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HOO69_15315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HOO69_15320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HOO69_15335	COG0203	ribosomal protein L17
HOO69_15345	COG0545	Peptidyl-prolyl cis-trans isomerase
HOO69_15360	COG2153	protein acetylation
HOO69_15370	COG0737	Belongs to the 5'-nucleotidase family
HOO69_15375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOO69_15375	COG1648	precorrin-2 dehydrogenase activity
HOO69_15380	COG0175	sulfate reduction
HOO69_15390	COG3273	potassium ion transport
HOO69_15390	COG0471	metal ion transport
HOO69_15395	COG0529	Catalyzes the synthesis of activated sulfate
HOO69_15405	COG0735	belongs to the Fur family
HOO69_15410	COG5002	protein histidine kinase activity
HOO69_15410	COG2205	protein histidine kinase activity
HOO69_15410	COG0784	Response regulator, receiver
HOO69_15415	COG3437	response regulator, receiver
HOO69_15440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HOO69_15445	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HOO69_15480	COG2801	Transposase and inactivated derivatives
HOO69_15505	COG0793	Belongs to the peptidase S41A family
HOO69_15505	COG4946	Tricorn protease homolog
HOO69_15580	COG0673	inositol 2-dehydrogenase activity
HOO69_15595	COG0251	oxidation-reduction process
HOO69_15605	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HOO69_15630	COG0148	phosphopyruvate hydratase activity
HOO69_15690	COG2274	protein secretion by the type I secretion system
HOO69_15700	COG0583	DNA-binding transcription factor activity
HOO69_15710	COG1309	transcriptional regulator
HOO69_15730	COG0840	transmembrane signaling receptor activity
HOO69_15745	COG1132	(ABC) transporter
HOO69_15750	COG1132	(ABC) transporter
HOO69_15785	COG0745	RESPONSE REGULATOR receiver
HOO69_15790	COG2205	protein histidine kinase activity
HOO69_15795	COG4452	Inner membrane protein CreD
HOO69_15810	COG0583	DNA-binding transcription factor activity
HOO69_15825	COG3710	Transcriptional regulator
HOO69_15870	COG1917	Cupin 2, conserved barrel domain protein
HOO69_15870	COG4977	sequence-specific DNA binding
HOO69_15885	COG2003	Belongs to the UPF0758 family
HOO69_16045	COG1714	RDD family
HOO69_16060	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_16080	COG1309	transcriptional regulator
HOO69_16095	COG0753	catalase activity
HOO69_16110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOO69_16120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOO69_16190	COG1192	Involved in chromosome partitioning
HOO69_16200	COG2814	Major facilitator Superfamily
HOO69_16225	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_16235	COG1902	pentaerythritol trinitrate reductase activity
HOO69_16240	COG1881	PFAM PEBP family protein
HOO69_16260	COG0814	amino acid
HOO69_16345	COG1716	ATPase activity
HOO69_16380	COG3501	Rhs element vgr protein
HOO69_16415	COG3710	Transcriptional regulator
HOO69_16435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HOO69_16440	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_16455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HOO69_16535	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HOO69_16545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOO69_16570	COG0529	Catalyzes the synthesis of activated sulfate
HOO69_16575	COG0471	metal ion transport
HOO69_16575	COG0490	domain, Protein
HOO69_16580	COG2895	sulfate adenylyltransferase (ATP) activity
HOO69_16585	COG0175	sulfate reduction
HOO69_16630	COG0346	lactoylglutathione lyase activity
HOO69_16640	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HOO69_16665	COG0768	penicillin binding
HOO69_16685	COG2026	Addiction module toxin, RelE StbE family
HOO69_16810	COG3706	GGDEF domain
HOO69_16850	COG3842	ATPase activity
HOO69_16855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOO69_16875	COG1175	transmembrane transport
HOO69_16880	COG0583	DNA-binding transcription factor activity
HOO69_16895	COG2814	Major facilitator Superfamily
HOO69_16900	COG3214	Protein conserved in bacteria
HOO69_16905	COG3321	synthase
HOO69_16905	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_16905	COG0604	alcohol dehydrogenase
HOO69_16915	COG0646	methionine synthase
HOO69_16915	COG1410	methionine synthase
HOO69_16920	COG2176	DNA-directed DNA polymerase activity
HOO69_16960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HOO69_16965	COG0840	transmembrane signaling receptor activity
HOO69_16970	COG0835	chemotaxis
HOO69_16985	COG0745	RESPONSE REGULATOR receiver
HOO69_16995	COG1444	tRNA N-acetyltransferase activity
HOO69_17025	COG4608	Belongs to the ABC transporter superfamily
HOO69_17030	COG0444	Belongs to the ABC transporter superfamily
HOO69_17065	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_17075	COG1733	regulation of RNA biosynthetic process
HOO69_17100	COG0110	maltose O-acetyltransferase activity
HOO69_17105	COG1278	Cold shock
HOO69_17115	COG1342	Belongs to the UPF0251 family
HOO69_17130	COG0583	DNA-binding transcription factor activity
HOO69_17150	COG0697	spore germination
HOO69_17180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOO69_17185	COG2135	peptidase activity
HOO69_17195	COG1846	Transcriptional regulator
HOO69_17205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HOO69_17210	COG3960	tartronate-semialdehyde synthase activity
HOO69_17220	COG2084	Dehydrogenase
HOO69_17225	COG3835	regulator
HOO69_17230	COG2610	gluconate transmembrane transporter activity
HOO69_17235	COG1929	Belongs to the glycerate kinase type-1 family
HOO69_17240	COG1901	pseudouridine methyltransferase
HOO69_17280	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HOO69_17300	COG0589	response to stress
HOO69_17335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HOO69_17335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HOO69_17340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HOO69_17355	COG0768	penicillin binding
HOO69_17375	COG0583	DNA-binding transcription factor activity
HOO69_17385	COG0351	phosphomethylpyrimidine kinase
HOO69_17390	COG1116	anion transmembrane transporter activity
HOO69_17395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOO69_17400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HOO69_17405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HOO69_17410	COG2199	diguanylate cyclase activity
HOO69_17410	COG2203	Gaf domain
HOO69_17415	COG0671	phosphoesterase, PA-phosphatase related
HOO69_17440	COG0583	DNA-binding transcription factor activity
HOO69_17475	COG0739	heme binding
HOO69_17485	COG1063	alcohol dehydrogenase
HOO69_17505	COG1595	DNA-templated transcription, initiation
HOO69_17545	COG4964	Belongs to the GSP D family
HOO69_17555	COG0455	bacterial-type flagellum organization
HOO69_17580	COG2885	chlorophyll binding
HOO69_17585	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HOO69_17605	COG0596	Alpha beta hydrolase
HOO69_17615	COG4221	oxidoreductase activity
HOO69_17620	COG0471	metal ion transport
HOO69_17625	COG2988	succinylglutamate desuccinylase activity
HOO69_17630	COG0523	cobalamin synthesis protein
HOO69_17635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HOO69_17645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HOO69_17660	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_17665	COG2814	Major facilitator Superfamily
HOO69_17670	COG1902	pentaerythritol trinitrate reductase activity
HOO69_17675	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_17710	COG0561	phosphatase activity
HOO69_17720	COG1454	alcohol dehydrogenase
HOO69_17725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOO69_17735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HOO69_17745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOO69_17750	COG1263	PTS System
HOO69_17750	COG2190	(PTS) system
HOO69_17750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_17760	COG0814	amino acid
HOO69_17765	COG2909	trisaccharide binding
HOO69_17770	COG0058	SHG alpha-glucan phosphorylase activity
HOO69_17775	COG1640	4-alpha-glucanotransferase
HOO69_17780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HOO69_17810	COG3710	Transcriptional regulator
HOO69_17860	COG1741	Belongs to the pirin family
HOO69_17880	COG1132	(ABC) transporter
HOO69_17895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HOO69_17915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HOO69_17920	COG1120	ATPase activity
HOO69_17925	COG2814	Major facilitator Superfamily
HOO69_17940	COG0786	glutamate:sodium symporter activity
HOO69_17960	COG1247	-acetyltransferase
HOO69_17980	COG0137	argininosuccinate synthase activity
HOO69_18020	COG2814	Major facilitator Superfamily
HOO69_18030	COG0642	Histidine kinase
HOO69_18035	COG0745	RESPONSE REGULATOR receiver
HOO69_18060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOO69_18075	COG0583	DNA-binding transcription factor activity
HOO69_18105	COG4533	DNA binding
HOO69_18110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOO69_18120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HOO69_18125	COG1151	hydroxylamine reductase activity
HOO69_18135	COG0671	phosphoesterase, PA-phosphatase related
HOO69_18150	COG1494	fructose-1,6-bisphosphatase
HOO69_18155	COG0698	ribose 5-phosphate isomerase
HOO69_18160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HOO69_18180	COG2376	Dihydroxyacetone kinase
HOO69_18185	COG1461	Dihydroxyacetone kinase
HOO69_18195	COG0679	Auxin Efflux Carrier
HOO69_18210	COG3604	Transcriptional regulator
HOO69_18230	COG2814	Major facilitator Superfamily
HOO69_18240	COG2329	Antibiotic biosynthesis monooxygenase
HOO69_18255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_18265	COG0583	DNA-binding transcription factor activity
HOO69_18280	COG2814	Major facilitator Superfamily
HOO69_18285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HOO69_18290	COG1940	carbohydrate kinase activity
HOO69_18295	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HOO69_18300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HOO69_18305	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HOO69_18310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HOO69_18315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOO69_18320	COG1737	Transcriptional regulator
HOO69_18325	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HOO69_18330	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HOO69_18335	COG4409	exo-alpha-(2->6)-sialidase activity
HOO69_18340	COG3706	GGDEF domain
HOO69_18350	COG4580	involved in the transport of maltose and maltodextrins
HOO69_18370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HOO69_18380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HOO69_18385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HOO69_18395	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HOO69_18400	COG3366	ferrous iron transmembrane transporter activity
HOO69_18405	COG0700	Nucleoside recognition
HOO69_18410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOO69_18415	COG0583	DNA-binding transcription factor activity
HOO69_18430	COG4774	siderophore transport
HOO69_18460	COG1280	lysine exporter protein (LysE YggA)
HOO69_18475	COG4232	protein-disulfide reductase activity
HOO69_18480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HOO69_18490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOO69_18500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HOO69_18505	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HOO69_18510	COG1845	cytochrome c oxidase, subunit III
HOO69_18530	COG1612	heme a metabolic process
HOO69_18535	COG0109	protoheme IX farnesyltransferase activity
HOO69_18545	COG0765	amino acid transport
HOO69_18550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_18555	COG0765	amino acid transport
HOO69_18560	COG1126	abc transporter atp-binding protein
HOO69_18565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HOO69_18575	COG4175	Glycine betaine
HOO69_18575	COG3448	diguanylate cyclase activity
HOO69_18580	COG4176	ABC-type proline glycine betaine transport system permease component
HOO69_18615	COG4964	Belongs to the GSP D family
HOO69_18625	COG2894	cell division
HOO69_18680	COG1477	protein flavinylation
HOO69_18700	COG4221	oxidoreductase activity
HOO69_18725	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HOO69_18730	COG1162	GTPase activity
HOO69_18740	COG1999	signal sequence binding
HOO69_18750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO69_18755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HOO69_18760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HOO69_18765	COG3033	Beta-eliminating lyase
HOO69_18805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HOO69_18830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOO69_18860	COG0840	transmembrane signaling receptor activity
HOO69_18865	COG0454	-acetyltransferase
HOO69_18890	COG1122	ATPase activity
HOO69_18900	COG1566	PFAM secretion protein HlyD family protein
HOO69_18910	COG3706	GGDEF domain
HOO69_18925	COG0813	purine-nucleoside phosphorylase activity
HOO69_18930	COG3272	Protein of unknown function (DUF1722)
HOO69_18935	COG0789	Transcriptional regulator
HOO69_18940	COG0415	Belongs to the DNA photolyase family
HOO69_18945	COG1388	LysM domain
HOO69_18945	COG1376	ErfK ybiS ycfS ynhG family protein
HOO69_18955	COG0513	Belongs to the DEAD box helicase family
HOO69_18965	COG0513	Belongs to the DEAD box helicase family
HOO69_18970	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HOO69_18985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HOO69_18995	COG0330	HflC and HflK could
HOO69_19005	COG2211	Major facilitator Superfamily
HOO69_19010	COG1486	melibiose metabolic process
HOO69_19015	COG2169	Transcriptional regulator
HOO69_19020	COG3842	ATPase activity
HOO69_19030	COG1175	transmembrane transport
HOO69_19035	COG3833	ABC-type maltose transport systems, permease component
HOO69_19085	COG0402	S-adenosylhomocysteine deaminase activity
HOO69_19090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HOO69_19095	COG2239	Acts as a magnesium transporter
HOO69_19100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO69_19125	COG0121	glutamine amidotransferase
HOO69_19135	COG0531	amino acid
HOO69_19155	COG0673	inositol 2-dehydrogenase activity
HOO69_19160	COG1765	OsmC-like protein
HOO69_19190	COG2304	oxidoreductase activity
HOO69_19195	COG2304	oxidoreductase activity
HOO69_19210	COG0714	Associated with various cellular activities
HOO69_19230	COG0583	DNA-binding transcription factor activity
HOO69_19255	COG3706	GGDEF domain
HOO69_19265	COG0401	homolog of Blt101
HOO69_19270	COG0633	Ferredoxin
HOO69_19270	COG0633	Ferredoxin
HOO69_19270	COG3217	Mosc domain protein beta barrel domain protein
HOO69_19270	COG3217	Mosc domain protein beta barrel domain protein
HOO69_19275	COG3706	GGDEF domain
HOO69_19290	COG0747	negative chemotaxis
HOO69_19295	COG0601	transmembrane transport
HOO69_19305	COG4172	Belongs to the ABC transporter superfamily
HOO69_19320	COG0366	Alpha amylase catalytic
HOO69_19345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HOO69_19355	COG3300	MHYT domain
HOO69_19355	COG5001	Diguanylate cyclase
HOO69_19360	COG0583	DNA-binding transcription factor activity
HOO69_19365	COG2814	Major facilitator Superfamily
HOO69_19385	COG0697	spore germination
HOO69_19395	COG0534	Mate efflux family protein
HOO69_19405	COG2249	NAD(P)H dehydrogenase (quinone) activity
HOO69_19420	COG3604	Transcriptional regulator
HOO69_19425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HOO69_19425	COG1017	nitric oxide dioxygenase activity
HOO69_19440	COG1278	Cold shock
HOO69_19445	COG3036	rescue of stalled ribosome
HOO69_19460	COG1686	Belongs to the peptidase S11 family
HOO69_19480	COG3530	Putative quorum-sensing-regulated virulence factor
HOO69_19495	COG4941	Belongs to the sigma-70 factor family
HOO69_19500	COG3795	YCII-related domain
HOO69_19505	COG1454	alcohol dehydrogenase
HOO69_19510	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HOO69_19520	COG1011	Hydrolase
HOO69_19560	COG1840	ABC-type Fe3 transport system, periplasmic component
HOO69_19570	COG3842	ATPase activity
HOO69_19600	COG2866	Carboxypeptidase
HOO69_19605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HOO69_19610	COG0583	DNA-binding transcription factor activity
HOO69_19615	COG1760	l-serine dehydratase
HOO69_19635	COG3706	GGDEF domain
HOO69_19640	COG0835	chemotaxis
HOO69_19640	COG0784	Response regulator, receiver
HOO69_19645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HOO69_19650	COG0737	Belongs to the 5'-nucleotidase family
HOO69_19665	COG0494	nUDIX hydrolase
HOO69_19675	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HOO69_19680	COG2814	Major facilitator Superfamily
HOO69_19700	COG2199	diguanylate cyclase activity
HOO69_19705	COG1846	Transcriptional regulator
HOO69_19710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HOO69_19715	COG2176	DNA-directed DNA polymerase activity
HOO69_19715	COG5002	protein histidine kinase activity
HOO69_19725	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HOO69_19745	COG0004	ammonium transporteR
HOO69_19750	COG4607	ABC-type enterochelin transport system periplasmic component
HOO69_19755	COG4206	TonB-dependent receptor
HOO69_19785	COG0840	transmembrane signaling receptor activity
HOO69_19805	COG0840	transmembrane signaling receptor activity
HOO69_19825	COG1115	amino acid carrier protein
HOO69_19840	COG0840	transmembrane signaling receptor activity
HOO69_19845	COG2199	diguanylate cyclase activity
HOO69_19845	COG2203	Gaf domain
HOO69_19865	COG3706	GGDEF domain
HOO69_19880	COG1024	Enoyl-CoA hydratase
HOO69_19885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HOO69_19890	COG1960	acyl-CoA dehydrogenase activity
HOO69_19900	COG0183	Belongs to the thiolase family
HOO69_19910	COG1960	acyl-CoA dehydrogenase activity
HOO69_19915	COG1024	Enoyl-CoA hydratase
HOO69_19920	COG1024	Enoyl-CoA hydratase
HOO69_19930	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_19935	COG0840	transmembrane signaling receptor activity
HOO69_19945	COG2315	Protein conserved in bacteria
HOO69_19955	COG0583	DNA-binding transcription factor activity
HOO69_19960	COG0277	FAD linked oxidase domain protein
HOO69_19975	COG5002	protein histidine kinase activity
HOO69_19975	COG5001	Diguanylate cyclase
HOO69_19990	COG0243	molybdopterin cofactor binding
HOO69_19995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOO69_19995	COG1648	precorrin-2 dehydrogenase activity
HOO69_20000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOO69_20010	COG1116	anion transmembrane transporter activity
HOO69_20010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HOO69_20015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOO69_20020	COG1116	anion transmembrane transporter activity
HOO69_20025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HOO69_20025	COG2146	nitrite reductase [NAD(P)H] activity
HOO69_20035	COG2197	response regulator
HOO69_20085	COG3118	belongs to the thioredoxin family
HOO69_20090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOO69_20095	COG0420	3'-5' exonuclease activity
HOO69_20100	COG0419	ATPase involved in DNA repair
HOO69_20105	COG0784	Response regulator, receiver
HOO69_20105	COG2205	protein histidine kinase activity
HOO69_20110	COG0156	8-amino-7-oxononanoate synthase activity
HOO69_20120	COG0038	chloride channel
HOO69_20125	COG0523	cobalamin synthesis protein
HOO69_20130	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HOO69_20140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOO69_20205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HOO69_20210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HOO69_20270	COG0840	transmembrane signaling receptor activity
HOO69_20275	COG4166	transmembrane transport
HOO69_20280	COG4174	ABC transporter (Permease)
HOO69_20285	COG4239	(ABC) transporter, permease
HOO69_20290	COG4172	Belongs to the ABC transporter superfamily
HOO69_20300	COG5001	Diguanylate cyclase
HOO69_20330	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOO69_20335	COG4605	iron ion homeostasis
HOO69_20340	COG4604	ABC transporter, ATP-binding protein
HOO69_20345	COG0789	Transcriptional regulator
HOO69_20365	COG5001	Diguanylate cyclase
HOO69_20365	COG3300	MHYT domain
HOO69_20370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOO69_20490	COG1742	UPF0060 membrane protein
HOO69_20555	COG3152	Membrane
HOO69_20575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO69_20610	COG0625	glutathione transferase activity
HOO69_20635	COG4628	conserved protein (DUF2132)
HOO69_20660	COG1309	transcriptional regulator
HOO69_20665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HOO69_20685	COG0183	Belongs to the thiolase family
HOO69_20700	COG1794	racemase activity, acting on amino acids and derivatives
HOO69_20705	COG2814	Major facilitator Superfamily
HOO69_20710	COG3240	lipase activity
HOO69_20790	COG1328	CTP reductase activity
HOO69_20795	COG0602	queuosine metabolic process
HOO69_20805	COG0189	ligase activity
HOO69_20805	COG4067	protein conserved in archaea
HOO69_20810	COG0494	nUDIX hydrolase
HOO69_20815	COG0545	Peptidyl-prolyl cis-trans isomerase
HOO69_20840	COG2926	Belongs to the UPF0265 family
HOO69_20855	COG2827	Endonuclease containing a URI domain
HOO69_20865	COG1879	ABC-type sugar transport system periplasmic component
HOO69_20870	COG0784	Response regulator, receiver
HOO69_20870	COG2205	protein histidine kinase activity
HOO69_20890	COG1289	transmembrane transporter activity
HOO69_20895	COG0210	DNA helicase
HOO69_20915	COG0484	heat shock protein binding
HOO69_20925	COG1116	anion transmembrane transporter activity
HOO69_20930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOO69_20935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO69_20945	COG5001	Diguanylate cyclase
HOO69_20945	COG1716	ATPase activity
HOO69_20950	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HOO69_20960	COG4181	ATPase activity
HOO69_20975	COG1984	allophanate hydrolase subunit 2
HOO69_20985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HOO69_20990	COG3300	MHYT domain
HOO69_20990	COG5001	Diguanylate cyclase
HOO69_21025	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HOO69_21025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HOO69_21030	COG3850	Histidine kinase
HOO69_21035	COG2197	response regulator
HOO69_21040	COG3069	C4-dicarboxylate transmembrane transporter activity
HOO69_21065	COG3038	cytochrome b561
HOO69_21070	COG2353	YceI-like domain
HOO69_21075	COG2116	formate transmembrane transporter activity
HOO69_21080	COG0583	DNA-binding transcription factor activity
HOO69_21090	COG3593	DNA synthesis involved in DNA repair
HOO69_21095	COG0737	Belongs to the 5'-nucleotidase family
HOO69_21125	COG0750	zinc metalloprotease
HOO69_21130	COG4783	chaperone-mediated protein folding
HOO69_21135	COG2050	protein possibly involved in aromatic compounds catabolism
HOO69_21155	COG1629	transport
HOO69_21155	COG4771	TonB-dependent receptor
HOO69_21160	COG0583	DNA-binding transcription factor activity
HOO69_21170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HOO69_21175	COG0363	glucosamine-6-phosphate deaminase activity
HOO69_21180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HOO69_21190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HOO69_21220	COG0156	8-amino-7-oxononanoate synthase activity
HOO69_21260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HOO69_21285	COG1716	ATPase activity
HOO69_21285	COG5001	Diguanylate cyclase
HOO69_21290	COG0798	PFAM Bile acid sodium symporter
HOO69_21300	COG0045	succinate-CoA ligase (ADP-forming) activity
HOO69_21300	COG1042	CoA-binding domain protein
HOO69_21300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOO69_21310	COG1181	Belongs to the D-alanine--D-alanine ligase family
HOO69_21325	COG0023	Translation Initiation Factor
HOO69_21485	COG3140	Belongs to the UPF0181 family
HOO69_21500	COG0745	RESPONSE REGULATOR receiver
HOO69_21510	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HOO69_21515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HOO69_21530	COG3706	GGDEF domain
HOO69_21535	COG3706	GGDEF domain
HOO69_21535	COG4251	negative regulation of phosphorylation
HOO69_21535	COG2203	Gaf domain
HOO69_21535	COG5001	Diguanylate cyclase
HOO69_21545	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HOO69_21550	COG4149	molybdate abc transporter
HOO69_21555	COG0725	ABC transporter, periplasmic molybdate-binding protein
HOO69_21560	COG1492	cobalamin metabolic process
HOO69_21565	COG3111	PFAM Bacterial OB fold (BOF) protein
HOO69_21575	COG1609	Transcriptional regulator
HOO69_21580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_21580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_21585	COG1105	Belongs to the carbohydrate kinase PfkB family
HOO69_21590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_21590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HOO69_21590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_21595	COG3706	GGDEF domain
HOO69_21600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HOO69_21610	COG2207	Transcriptional regulator
HOO69_21615	COG1979	alcohol dehydrogenase
HOO69_21630	COG2205	protein histidine kinase activity
HOO69_21630	COG2198	Histidine kinase
HOO69_21630	COG0784	Response regulator, receiver
HOO69_21635	COG1879	ABC-type sugar transport system periplasmic component
HOO69_21640	COG1803	Methylglyoxal synthase
HOO69_21650	COG0546	phosphoglycolate phosphatase activity
HOO69_21665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOO69_21670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOO69_21695	COG0456	acetyltransferase
HOO69_21695	COG1214	PFAM Peptidase M22, glycoprotease
HOO69_21715	COG0513	Belongs to the DEAD box helicase family
HOO69_21725	COG0814	amino acid
HOO69_21730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOO69_21730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOO69_21745	COG0513	Belongs to the DEAD box helicase family
HOO69_21755	COG0303	'Molybdopterin
HOO69_21760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HOO69_21775	COG2897	thiosulfate sulfurtransferase activity
HOO69_21830	COG4964	Belongs to the GSP D family
HOO69_21850	COG0583	DNA-binding transcription factor activity
HOO69_21865	COG0583	DNA-binding transcription factor activity
HOO69_21880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HOO69_21885	COG1522	sequence-specific DNA binding
HOO69_21890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HOO69_21900	COG0840	transmembrane signaling receptor activity
HOO69_21910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOO69_21915	COG1067	ATP-dependent peptidase activity
HOO69_21925	COG4172	Belongs to the ABC transporter superfamily
HOO69_21935	COG0583	DNA-binding transcription factor activity
HOO69_21940	COG1620	l-lactate permease
HOO69_21945	COG1304	FMN binding
HOO69_22005	COG0463	Glycosyl transferase, family 2
HOO69_22030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HOO69_22050	COG3284	Transcriptional regulator
HOO69_22055	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_22095	COG2205	protein histidine kinase activity
HOO69_22100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_22100	COG1263	PTS System
HOO69_22105	COG4175	Glycine betaine
HOO69_22125	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_22135	COG5002	protein histidine kinase activity
HOO69_22135	COG0784	Response regulator, receiver
HOO69_22135	COG2205	protein histidine kinase activity
HOO69_22140	COG0745	RESPONSE REGULATOR receiver
HOO69_22160	COG4774	siderophore transport
HOO69_22175	COG3251	PFAM MbtH domain protein
HOO69_22180	COG4615	Cyclic peptide transporter
HOO69_22190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HOO69_22195	COG1120	ATPase activity
HOO69_22235	COG1121	(ABC) transporter
HOO69_22240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HOO69_22280	COG0516	GMP reductase activity
HOO69_22295	COG0516	GMP reductase activity
HOO69_22305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HOO69_22320	COG2375	cellular response to nickel ion
HOO69_22325	COG0583	DNA-binding transcription factor activity
HOO69_22335	COG0564	pseudouridine synthase activity
HOO69_22360	COG0513	Belongs to the DEAD box helicase family
HOO69_22370	COG3706	GGDEF domain
HOO69_22375	COG1309	transcriptional regulator
HOO69_22380	COG2130	NADP-dependent
HOO69_22395	COG2084	Dehydrogenase
HOO69_22410	COG0366	Alpha amylase catalytic
HOO69_22415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOO69_22420	COG0625	glutathione transferase activity
HOO69_22460	COG0745	RESPONSE REGULATOR receiver
HOO69_22480	COG1309	transcriptional regulator
HOO69_22515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HOO69_22520	COG3300	MHYT domain
HOO69_22520	COG5001	Diguanylate cyclase
HOO69_22545	COG1271	oxidase subunit
HOO69_22550	COG1294	oxidase, subunit
HOO69_22595	COG4969	Belongs to the N-Me-Phe pilin family
HOO69_22600	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HOO69_22615	COG1357	PFAM Pentapeptide repeats (8 copies)
HOO69_22630	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HOO69_22670	COG0443	Heat shock 70 kDa protein
HOO69_22675	COG0583	DNA-binding transcription factor activity
HOO69_22685	COG4948	Mandelate Racemase Muconate Lactonizing
HOO69_22705	COG0366	Alpha amylase catalytic
HOO69_22710	COG2182	Extracellular solute-binding protein
HOO69_22720	COG0366	Alpha amylase catalytic
HOO69_22735	COG3275	phosphorelay sensor kinase activity
HOO69_22750	COG4591	ABC-type transport system involved in lipoprotein release permease component
HOO69_22755	COG1136	(ABC) transporter
HOO69_22775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO69_22780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOO69_22820	COG2154	pterin-4-alpha-carbinolamine dehydratase
HOO69_22825	COG3186	Phenylalanine-4-hydroxylase
HOO69_22830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HOO69_22850	COG0384	phenazine biosynthesis protein PhzF
HOO69_22870	COG2226	methyltransferase
HOO69_22895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HOO69_22905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HOO69_22910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HOO69_22910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HOO69_22920	COG0745	RESPONSE REGULATOR receiver
HOO69_22925	COG3437	response regulator, receiver
HOO69_22930	COG4999	Histidine kinase
HOO69_22930	COG3850	Histidine kinase
HOO69_22930	COG3437	response regulator, receiver
HOO69_22930	COG2205	protein histidine kinase activity
HOO69_22940	COG2172	sigma factor antagonist activity
HOO69_22950	COG1366	Belongs to the anti-sigma-factor antagonist family
HOO69_22955	COG0840	transmembrane signaling receptor activity
HOO69_22995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOO69_23005	COG2096	Adenosyltransferase
HOO69_23010	COG0748	coenzyme F420 binding
HOO69_23015	COG3721	Heme iron utilization protein
HOO69_23025	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HOO69_23030	COG0811	peptide transport
HOO69_23035	COG0848	biopolymer transport protein
HOO69_23045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOO69_23050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HOO69_23070	COG3047	cAMP biosynthetic process
HOO69_23075	COG0739	heme binding
HOO69_23110	COG2203	Gaf domain
HOO69_23110	COG2199	diguanylate cyclase activity
HOO69_23145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HOO69_23150	COG0581	inorganic phosphate transmembrane transporter activity
HOO69_23155	COG0573	inorganic phosphate transmembrane transporter activity
HOO69_23165	COG0840	transmembrane signaling receptor activity
HOO69_23180	COG0835	chemotaxis
HOO69_23180	COG0784	Response regulator, receiver
HOO69_23190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_23190	COG4191	Histidine kinase
HOO69_23195	COG3437	response regulator, receiver
HOO69_23195	COG0784	Response regulator, receiver
HOO69_23200	COG1609	Transcriptional regulator
HOO69_23205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOO69_23210	COG1879	ABC-type sugar transport system periplasmic component
HOO69_23215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOO69_23220	COG1129	ABC transporter
HOO69_23225	COG1869	D-ribose catabolic process
HOO69_23235	COG0004	ammonium transporteR
HOO69_23255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HOO69_23265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOO69_23270	COG0509	glycine decarboxylation via glycine cleavage system
HOO69_23285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HOO69_23305	COG4191	Histidine kinase
HOO69_23305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_23330	COG1396	sequence-specific DNA binding
HOO69_23340	COG1280	lysine exporter protein (LysE YggA)
HOO69_23355	COG3501	Rhs element vgr protein
HOO69_23415	COG1609	Transcriptional regulator
HOO69_23420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HOO69_23425	COG3265	gluconokinase activity
HOO69_23430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HOO69_23435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HOO69_23440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HOO69_23480	COG1032	radical SAM domain protein
HOO69_23500	COG0668	transmembrane transport
HOO69_23505	COG2211	Major facilitator Superfamily
HOO69_23520	COG0366	Alpha amylase catalytic
HOO69_23580	COG4191	Histidine kinase
HOO69_23580	COG0784	Response regulator, receiver
HOO69_23590	COG0561	phosphatase activity
HOO69_23595	COG0346	lactoylglutathione lyase activity
HOO69_23610	COG0456	acetyltransferase
HOO69_23650	COG0697	spore germination
HOO69_23655	COG0583	DNA-binding transcription factor activity
HOO69_23685	COG3706	GGDEF domain
HOO69_23690	COG0488	(ABC) transporter
HOO69_23695	COG0348	domain, Protein
HOO69_23700	COG0437	4 iron, 4 sulfur cluster binding
HOO69_23705	COG3383	formate dehydrogenase (NAD+) activity
HOO69_23750	COG1683	Conserved Protein
HOO69_23775	COG0183	Belongs to the thiolase family
HOO69_23780	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_23805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HOO69_23830	COG0346	lactoylglutathione lyase activity
HOO69_23855	COG5001	Diguanylate cyclase
HOO69_23855	COG3300	MHYT domain
HOO69_23870	COG2814	Major facilitator Superfamily
HOO69_23880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOO69_23885	COG2423	ornithine cyclodeaminase activity
HOO69_23890	COG2022	thiamine diphosphate biosynthetic process
HOO69_23890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HOO69_23895	COG3938	Belongs to the proline racemase family
HOO69_23915	COG0745	RESPONSE REGULATOR receiver
HOO69_23925	COG1653	transport
HOO69_23935	COG5001	Diguanylate cyclase
HOO69_23935	COG5002	protein histidine kinase activity
HOO69_23965	COG0601	transmembrane transport
HOO69_23970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOO69_23990	COG4628	conserved protein (DUF2132)
HOO69_23995	COG0024	Methionine aminopeptidase
HOO69_24025	COG2186	Transcriptional regulator
HOO69_24035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HOO69_24045	COG0246	Mannitol dehydrogenase
HOO69_24055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOO69_24060	COG0800	Aldolase
HOO69_24115	COG3568	Endonuclease Exonuclease Phosphatase
HOO69_24120	COG3291	Pkd domain containing protein
HOO69_24130	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_24160	COG1671	Belongs to the UPF0178 family
HOO69_24165	COG1280	lysine exporter protein (LysE YggA)
HOO69_24170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOO69_24175	COG1301	dicarboxylic acid transport
HOO69_24180	COG2199	diguanylate cyclase activity
HOO69_24180	COG2200	EAL domain
HOO69_24215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOO69_24220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOO69_24245	COG2986	histidine ammonia-lyase
HOO69_24270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOO69_24275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HOO69_24280	COG1028	Short-chain dehydrogenase reductase Sdr
HOO69_24290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HOO69_24300	COG1278	Cold shock
HOO69_24305	COG3122	Protein conserved in bacteria
HOO69_24310	COG1166	arginine decarboxylase activity
HOO69_24315	COG0010	Belongs to the arginase family
HOO69_24350	COG2186	Transcriptional regulator
HOO69_24370	COG0402	S-adenosylhomocysteine deaminase activity
HOO69_24375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOO69_24380	COG0840	transmembrane signaling receptor activity
HOO69_24385	COG0784	Response regulator, receiver
HOO69_24385	COG5002	protein histidine kinase activity
HOO69_24385	COG2205	protein histidine kinase activity
HOO69_24400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HOO69_24415	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HOO69_24420	COG0804	urea catabolic process
HOO69_24425	COG0832	Belongs to the urease beta subunit family
HOO69_24430	COG0831	urea catabolic process
HOO69_24455	COG0559	Belongs to the binding-protein-dependent transport system permease family
HOO69_24465	COG1404	Belongs to the peptidase S8 family
HOO69_24475	COG0840	transmembrane signaling receptor activity
HOO69_24485	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HOO69_24490	COG4266	Belongs to the allantoicase family
HOO69_24510	COG2252	PERMEase
HOO69_24575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_24580	COG1609	Transcriptional regulator
HOO69_24590	COG1280	lysine exporter protein (LysE YggA)
HOO69_24605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HOO69_24615	COG1012	belongs to the aldehyde dehydrogenase family
HOO69_24630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HOO69_24635	COG1482	cell wall glycoprotein biosynthetic process
HOO69_24640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_24640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_24640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_24650	COG0383	alpha-mannosidase activity
HOO69_24655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_24655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOO69_24655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_24675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HOO69_24680	COG3394	polysaccharide catabolic process
HOO69_24700	COG3453	Protein conserved in bacteria
HOO69_24700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HOO69_24710	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HOO69_24715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HOO69_24725	COG1733	regulation of RNA biosynthetic process
HOO69_24740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOO69_24755	COG1418	mRNA catabolic process
HOO69_24770	COG2814	Major facilitator Superfamily
HOO69_24790	COG3639	organic phosphonate transmembrane transporter activity
HOO69_24795	COG3639	organic phosphonate transmembrane transporter activity
HOO69_24800	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HOO69_24850	COG0242	peptide deformylase activity
HOO69_24860	COG0596	Alpha beta hydrolase
HOO69_24865	COG0583	DNA-binding transcription factor activity
HOO69_24870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HOO69_24875	COG0569	domain protein
HOO69_24885	COG2205	protein histidine kinase activity
HOO69_24905	COG2706	6-phosphogluconolactonase activity
HOO69_24915	COG0800	Aldolase
HOO69_24925	COG4145	pantothenate transmembrane transporter activity
HOO69_24935	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HOO69_24955	COG1131	(ABC) transporter
HOO69_24960	COG2188	Transcriptional regulator
HOO69_24980	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOO69_24985	COG3716	PTS system mannose fructose sorbose family IID component
HOO69_24995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOO69_25000	COG2222	sugar isomerase
HOO69_25010	COG1349	DNA-binding transcription factor activity
HOO69_25015	COG1349	DNA-binding transcription factor activity
HOO69_25030	COG1136	(ABC) transporter
HOO69_25065	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOO69_25085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HOO69_25095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HOO69_25100	COG0527	aspartate kinase activity
HOO69_25105	COG0662	Cupin 2, conserved barrel domain protein
HOO69_25110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HOO69_25115	COG0456	acetyltransferase
HOO69_25125	COG1917	Cupin 2, conserved barrel domain protein
HOO69_25125	COG4977	sequence-specific DNA binding
HOO69_25130	COG1280	lysine exporter protein (LysE YggA)
HOO69_25135	COG1522	sequence-specific DNA binding
HOO69_25145	COG2258	MOSC domain
HOO69_25150	COG1609	Transcriptional regulator
HOO69_25155	COG1757	Na H antiporter
HOO69_25160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities