locus-tag	class	description
HPK20_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPK20_00010	COG0592	DNA-directed DNA polymerase activity
HPK20_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPK20_00020	COG0187	DNA topoisomerase II activity
HPK20_00025	COG0071	Belongs to the small heat shock protein (HSP20) family
HPK20_00030	COG3977	Valine--pyruvate aminotransferase
HPK20_00035	COG0751	glycine-tRNA ligase activity
HPK20_00040	COG0752	glycyl-tRNA synthetase alpha subunit
HPK20_00045	COG2119	membrane
HPK20_00055	COG0425	Belongs to the sulfur carrier protein TusA family
HPK20_00070	COG0604	alcohol dehydrogenase
HPK20_00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK20_00090	COG3978	acetolactate synthase activity
HPK20_00100	COG0606	chelatase, subunit chli
HPK20_00145	COG0204	Acyl-transferase
HPK20_00150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPK20_00155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPK20_00165	COG3084	Protein conserved in bacteria
HPK20_00170	COG4326	sporulation control protein
HPK20_00175	COG1272	protein, Hemolysin III
HPK20_00185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK20_00190	COG0569	domain protein
HPK20_00195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPK20_00195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK20_00205	COG0242	peptide deformylase activity
HPK20_00210	COG1652	LysM domain
HPK20_00215	COG0758	DNA mediated transformation
HPK20_00220	COG2922	Belongs to the Smg family
HPK20_00225	COG0551	DNA topoisomerase type I activity
HPK20_00230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPK20_00235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPK20_00245	COG0408	coproporphyrinogen oxidase activity
HPK20_00250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPK20_00260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPK20_00300	COG0583	DNA-binding transcription factor activity
HPK20_00305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPK20_00310	COG2960	long-chain fatty acid transporting porin activity
HPK20_00315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_00320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_00330	COG0210	DNA helicase
HPK20_00370	COG0747	negative chemotaxis
HPK20_00380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_00390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_00395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_00410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK20_00415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPK20_00450	COG0210	DNA helicase
HPK20_00455	COG0405	Gamma-glutamyltransferase
HPK20_00460	COG1280	lysine exporter protein (LysE YggA)
HPK20_00470	COG2962	Rard protein
HPK20_00475	COG0514	ATP-dependent DNA helicase (RecQ)
HPK20_00490	COG1132	(ABC) transporter
HPK20_00495	COG1120	ATPase activity
HPK20_00500	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPK20_00515	COG2862	Uncharacterized protein family, UPF0114
HPK20_00520	COG1561	YicC-like family, N-terminal region
HPK20_00525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPK20_00530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPK20_00535	COG1560	Kdo2-lipid A biosynthetic process
HPK20_00540	COG1309	transcriptional regulator
HPK20_00555	COG2003	Belongs to the UPF0758 family
HPK20_00565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPK20_00575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPK20_00590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPK20_00595	COG0438	transferase activity, transferring glycosyl groups
HPK20_00600	COG0438	transferase activity, transferring glycosyl groups
HPK20_00605	COG0463	Glycosyl transferase, family 2
HPK20_00610	COG0859	PFAM glycosyl transferase family 9
HPK20_00615	COG3642	lipopolysaccharide core region biosynthetic process
HPK20_00620	COG1519	Transferase
HPK20_00625	COG0859	PFAM glycosyl transferase family 9
HPK20_00640	COG0297	glycogen (starch) synthase activity
HPK20_00640	COG0438	transferase activity, transferring glycosyl groups
HPK20_00655	COG1560	Kdo2-lipid A biosynthetic process
HPK20_00665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK20_00670	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_00700	COG3206	protein involved in exopolysaccharide biosynthesis
HPK20_00700	COG0489	protein tyrosine kinase activity
HPK20_00705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPK20_00710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPK20_00730	COG2843	Capsule synthesis protein
HPK20_00765	COG0582	viral genome integration into host DNA
HPK20_00805	COG1482	cell wall glycoprotein biosynthetic process
HPK20_00810	COG2271	Major facilitator Superfamily
HPK20_00815	COG3851	Histidine kinase
HPK20_00820	COG2197	response regulator
HPK20_00835	COG1129	ABC transporter
HPK20_00840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPK20_00885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPK20_00920	COG2843	Capsule synthesis protein
HPK20_00930	COG0438	transferase activity, transferring glycosyl groups
HPK20_00935	COG0438	transferase activity, transferring glycosyl groups
HPK20_00940	COG3562	capsule polysaccharide
HPK20_00945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK20_00950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPK20_00955	COG1573	uracil-dna glycosylase
HPK20_00960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_00965	COG3068	Protein conserved in bacteria
HPK20_00970	COG0668	transmembrane transport
HPK20_00975	COG1253	flavin adenine dinucleotide binding
HPK20_00980	COG0776	regulation of translation
HPK20_00995	COG0151	Belongs to the GarS family
HPK20_01000	COG0138	bifunctional purine biosynthesis protein purh
HPK20_01010	COG0789	Transcriptional regulator
HPK20_01015	COG0840	transmembrane signaling receptor activity
HPK20_01020	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPK20_01025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK20_01030	COG2264	protein methyltransferase activity
HPK20_01035	COG0439	Biotin carboxylase
HPK20_01040	COG0511	ligase activity, forming carbon-carbon bonds
HPK20_01045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPK20_01050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK20_01065	COG2814	Major facilitator Superfamily
HPK20_01070	COG0784	Response regulator, receiver
HPK20_01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_01070	COG2198	Histidine kinase
HPK20_01070	COG2205	protein histidine kinase activity
HPK20_01075	COG0248	Ppx GppA phosphatase
HPK20_01080	COG0513	Belongs to the DEAD box helicase family
HPK20_01085	COG3118	belongs to the thioredoxin family
HPK20_01100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPK20_01165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPK20_01175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPK20_01185	COG1072	(Pantothenic acid kinase))
HPK20_01215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK20_01220	COG0250	Participates in transcription elongation, termination and antitermination
HPK20_01225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPK20_01235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPK20_01240	COG0222	ribosome binding
HPK20_01245	COG0085	RNA polymerase activity
HPK20_01250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPK20_01255	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPK20_01260	COG2816	NAD+ diphosphatase activity
HPK20_01265	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPK20_01280	COG4942	peptidase
HPK20_01285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPK20_01300	COG0490	domain, Protein
HPK20_01300	COG0471	metal ion transport
HPK20_01305	COG0688	phosphatidylethanolamine metabolic process
HPK20_01310	COG1162	GTPase activity
HPK20_01365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPK20_01370	COG0802	atpase or kinase
HPK20_01380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPK20_01385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPK20_01390	COG1923	regulation of RNA biosynthetic process
HPK20_01395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPK20_01400	COG0330	HflC and HflK could
HPK20_01405	COG0330	HflC and HflK could
HPK20_01410	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPK20_01415	COG2900	Belongs to the SlyX family
HPK20_01425	COG0545	Peptidyl-prolyl cis-trans isomerase
HPK20_01430	COG2964	Protein conserved in bacteria
HPK20_01435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPK20_01440	COG2923	Belongs to the DsrF TusC family
HPK20_01445	COG2168	tRNA wobble position uridine thiolation
HPK20_01455	COG0049	tRNA binding
HPK20_01460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPK20_01470	COG2906	2 iron, 2 sulfur cluster binding
HPK20_01480	COG0360	Binds together with S18 to 16S ribosomal RNA
HPK20_01485	COG2965	DNA replication, synthesis of RNA primer
HPK20_01495	COG0359	binds to the 23S rRNA
HPK20_01510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK20_01520	COG0166	Belongs to the GPI family
HPK20_01530	COG0735	belongs to the Fur family
HPK20_01535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPK20_01555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPK20_01565	COG0175	sulfate reduction
HPK20_01635	COG1410	methionine synthase
HPK20_01635	COG0646	methionine synthase
HPK20_01640	COG0527	aspartate kinase activity
HPK20_01645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPK20_01655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPK20_01670	COG0629	single-stranded DNA binding
HPK20_01675	COG2200	EAL domain
HPK20_01675	COG2199	diguanylate cyclase activity
HPK20_01700	COG3409	Peptidoglycan-binding domain 1 protein
HPK20_01700	COG3267	Type II secretory pathway component ExeA
HPK20_01710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK20_01760	COG1077	Cell shape determining protein MreB Mrl
HPK20_01765	COG1792	Involved in formation and maintenance of cell shape
HPK20_01770	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPK20_01775	COG0424	maF-like protein
HPK20_01780	COG1530	ribonuclease E activity
HPK20_01785	COG3164	Protein of unknown function
HPK20_01790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK20_01795	COG0312	modulator of DNA gyrase
HPK20_01815	COG0589	response to stress
HPK20_01835	COG0039	L-malate dehydrogenase activity
HPK20_01840	COG0531	amino acid
HPK20_01845	COG0142	geranyltranstransferase activity
HPK20_01850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPK20_01860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPK20_01865	COG2966	Psort location CytoplasmicMembrane, score
HPK20_01870	COG3610	response to peptide
HPK20_01880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPK20_01885	COG2967	ApaG domain
HPK20_01890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPK20_01895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPK20_01900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPK20_01905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPK20_01910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPK20_01965	COG0741	lytic transglycosylase activity
HPK20_01970	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPK20_01975	COG1194	a g-specific adenine glycosylase
HPK20_01985	COG2066	Belongs to the glutaminase family
HPK20_01990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK20_01995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK20_02000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPK20_02010	COG1872	DUF167
HPK20_02015	COG0762	integral membrane protein
HPK20_02020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPK20_02025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPK20_02040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPK20_02045	COG1678	Uncharacterized ACR, COG1678
HPK20_02050	COG0189	ligase activity
HPK20_02055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPK20_02060	COG2356	endonuclease I
HPK20_02075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPK20_02080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPK20_02085	COG0583	DNA-binding transcription factor activity
HPK20_02090	COG4771	TonB-dependent receptor
HPK20_02095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK20_02100	COG0126	phosphoglycerate kinase activity
HPK20_02105	COG0191	fructose-bisphosphate aldolase activity
HPK20_02110	COG0668	transmembrane transport
HPK20_02135	COG3706	GGDEF domain
HPK20_02145	COG1349	DNA-binding transcription factor activity
HPK20_02150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPK20_02155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_02170	COG2239	Acts as a magnesium transporter
HPK20_02200	COG1610	YqeY-like protein
HPK20_02205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPK20_02210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPK20_02215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPK20_02220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPK20_02225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPK20_02230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK20_02240	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPK20_02245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPK20_02255	COG0585	pseudouridine synthase activity
HPK20_02260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPK20_02270	COG1388	LysM domain
HPK20_02270	COG4942	peptidase
HPK20_02275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPK20_02280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPK20_02285	COG1546	Belongs to the CinA family
HPK20_02290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPK20_02300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK20_02305	COG0527	aspartate kinase activity
HPK20_02355	COG3630	sodium ion export across plasma membrane
HPK20_02360	COG0511	ligase activity, forming carbon-carbon bonds
HPK20_02360	COG5016	pyruvate
HPK20_02365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPK20_02370	COG1063	alcohol dehydrogenase
HPK20_02375	COG1238	metal cluster binding
HPK20_02380	COG0612	Peptidase, M16
HPK20_02395	COG1854	S-ribosylhomocysteine lyase activity
HPK20_02400	COG4536	flavin adenine dinucleotide binding
HPK20_02405	COG4137	Cytochrome C assembly protein
HPK20_02410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPK20_02420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPK20_02430	COG0335	large ribosomal subunit rRNA binding
HPK20_02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK20_02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPK20_02445	COG3105	Protein conserved in bacteria
HPK20_02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPK20_02455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPK20_02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPK20_02465	COG0723	plastoquinol--plastocyanin reductase activity
HPK20_02470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPK20_02475	COG2857	Cytochrome c1
HPK20_02480	COG0625	glutathione transferase activity
HPK20_02485	COG2969	positive regulation of protein catabolic process
HPK20_02490	COG2823	Periplasmic or secreted lipoprotein
HPK20_02495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPK20_02500	COG0792	nuclease activity
HPK20_02505	COG3107	peptidoglycan biosynthetic process
HPK20_02510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPK20_02525	COG3116	cell division
HPK20_02530	COG0768	penicillin binding
HPK20_02535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPK20_02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPK20_02550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPK20_02555	COG0772	Belongs to the SEDS family
HPK20_02560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPK20_02565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPK20_02570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPK20_02575	COG0849	cell division
HPK20_02580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPK20_02585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPK20_02595	COG0653	protein targeting
HPK20_02600	COG0494	nUDIX hydrolase
HPK20_02610	COG0505	Belongs to the CarA family
HPK20_02615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPK20_02620	COG0730	response to heat
HPK20_02625	COG0583	DNA-binding transcription factor activity
HPK20_02645	COG2860	membrane
HPK20_02650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK20_02670	COG0493	'glutamate synthase
HPK20_02675	COG0067	glutamate synthase
HPK20_02675	COG0069	glutamate synthase activity
HPK20_02675	COG0070	glutamate synthase
HPK20_02685	COG0069	glutamate synthase activity
HPK20_02685	COG0070	glutamate synthase
HPK20_02685	COG0067	glutamate synthase
HPK20_02690	COG1242	4 iron, 4 sulfur cluster binding
HPK20_02695	COG3706	GGDEF domain
HPK20_02695	COG4251	negative regulation of phosphorylation
HPK20_02695	COG5001	Diguanylate cyclase
HPK20_02695	COG2203	Gaf domain
HPK20_02700	COG5002	protein histidine kinase activity
HPK20_02700	COG0784	Response regulator, receiver
HPK20_02700	COG2198	Histidine kinase
HPK20_02710	COG0745	RESPONSE REGULATOR receiver
HPK20_02720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK20_02735	COG0083	homoserine kinase activity
HPK20_02740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPK20_02745	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPK20_02760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPK20_02775	COG1115	amino acid carrier protein
HPK20_02780	COG3022	response to hydroperoxide
HPK20_02790	COG0084	hydrolase, TatD family'
HPK20_02815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK20_02820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPK20_02825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPK20_02830	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPK20_02835	COG0813	purine-nucleoside phosphorylase activity
HPK20_02845	COG0560	Phosphoserine phosphatase
HPK20_02855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPK20_02860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPK20_02865	COG0583	DNA-binding transcription factor activity
HPK20_02875	COG0583	DNA-binding transcription factor activity
HPK20_02915	COG4964	Belongs to the GSP D family
HPK20_02965	COG3437	response regulator, receiver
HPK20_02965	COG0784	Response regulator, receiver
HPK20_02970	COG2059	Chromate
HPK20_02985	COG2017	converts alpha-aldose to the beta-anomer
HPK20_02990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_03005	COG0569	domain protein
HPK20_03005	COG0189	ligase activity
HPK20_03020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPK20_03025	COG2171	N-acyltransferase activity
HPK20_03030	COG3141	response to X-ray
HPK20_03035	COG0583	DNA-binding transcription factor activity
HPK20_03045	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPK20_03050	COG1074	ATP-dependent DNA helicase activity
HPK20_03055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPK20_03065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPK20_03065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPK20_03075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPK20_03080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPK20_03085	COG2166	iron-sulfur cluster assembly
HPK20_03095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK20_03100	COG0693	protein deglycase activity
HPK20_03105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK20_03110	COG3248	Nucleoside-binding outer membrane protein
HPK20_03120	COG1595	DNA-templated transcription, initiation
HPK20_03130	COG0477	Major facilitator Superfamily
HPK20_03135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPK20_03150	COG0745	RESPONSE REGULATOR receiver
HPK20_03155	COG5002	protein histidine kinase activity
HPK20_03170	COG0248	Ppx GppA phosphatase
HPK20_03175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPK20_03180	COG0573	inorganic phosphate transmembrane transporter activity
HPK20_03185	COG0581	inorganic phosphate transmembrane transporter activity
HPK20_03190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPK20_03195	COG0704	Plays a role in the regulation of phosphate uptake
HPK20_03210	COG0450	alkyl hydroperoxide reductase
HPK20_03215	COG0583	DNA-binding transcription factor activity
HPK20_03220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPK20_03230	COG0517	IMP dehydrogenase activity
HPK20_03235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPK20_03245	COG1862	Preprotein translocase
HPK20_03250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_03255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_03260	COG1335	isochorismatase
HPK20_03265	COG0483	inositol monophosphate 1-phosphatase activity
HPK20_03270	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HPK20_03275	COG1959	2 iron, 2 sulfur cluster binding
HPK20_03280	COG1104	cysteine desulfurase activity
HPK20_03285	COG0822	iron-sulfur transferase activity
HPK20_03300	COG0443	Heat shock 70 kDa protein
HPK20_03305	COG0633	Ferredoxin
HPK20_03310	COG2975	iron-sulfur cluster assembly
HPK20_03315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPK20_03320	COG0105	UTP biosynthetic process
HPK20_03330	COG1426	Protein conserved in bacteria
HPK20_03335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPK20_03340	COG0124	histidyl-tRNA synthetase
HPK20_03345	COG2976	Protein conserved in bacteria
HPK20_03350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_03355	COG1160	GTP binding
HPK20_03370	COG1570	exodeoxyribonuclease VII activity
HPK20_03375	COG0517	IMP dehydrogenase activity
HPK20_03375	COG0516	GMP reductase activity
HPK20_03380	COG0519	Catalyzes the synthesis of GMP from XMP
HPK20_03380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPK20_03385	COG0582	viral genome integration into host DNA
HPK20_03470	COG1584	GPR1 FUN34 yaaH family protein
HPK20_03485	COG1473	amidohydrolase
HPK20_03495	COG1115	amino acid carrier protein
HPK20_03505	COG0583	DNA-binding transcription factor activity
HPK20_03605	COG0210	DNA helicase
HPK20_03630	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPK20_03645	COG0582	viral genome integration into host DNA
HPK20_03655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPK20_03660	COG2867	negative regulation of translational initiation
HPK20_03665	COG2914	Belongs to the UPF0125 (RnfH) family
HPK20_03670	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_03675	COG0497	DNA recombination
HPK20_03680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPK20_03685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPK20_03695	COG0443	Heat shock 70 kDa protein
HPK20_03700	COG0484	heat shock protein binding
HPK20_03705	COG4969	Belongs to the N-Me-Phe pilin family
HPK20_03730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_03740	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HPK20_03745	COG0583	DNA-binding transcription factor activity
HPK20_03750	COG0590	tRNA wobble adenosine to inosine editing
HPK20_03755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPK20_03780	COG0442	prolyl-tRNA aminoacylation
HPK20_03785	COG1720	tRNA m6t6A37 methyltransferase activity
HPK20_03790	COG0254	rRNA binding
HPK20_03795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPK20_03800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_03805	COG1671	Belongs to the UPF0178 family
HPK20_03830	COG3098	single-species biofilm formation
HPK20_03835	COG0564	pseudouridine synthase activity
HPK20_03840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPK20_03845	COG0142	geranyltranstransferase activity
HPK20_03850	COG1722	exodeoxyribonuclease VII activity
HPK20_03855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPK20_03865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_03865	COG0301	tRNA thio-modification
HPK20_03870	COG0583	DNA-binding transcription factor activity
HPK20_03880	COG2363	Small membrane protein
HPK20_03890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK20_03895	COG1611	Belongs to the LOG family
HPK20_03910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPK20_03910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPK20_03920	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPK20_03925	COG1464	Belongs to the NlpA lipoprotein family
HPK20_03930	COG2011	ABC-type metal ion transport system permease component
HPK20_03935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPK20_03940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPK20_03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_03955	COG1263	PTS System
HPK20_03960	COG0366	Alpha amylase catalytic
HPK20_03985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_03990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_04000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPK20_04010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPK20_04015	COG0321	lipoyl(octanoyl) transferase activity
HPK20_04020	COG2921	Belongs to the UPF0250 family
HPK20_04025	COG1686	Belongs to the peptidase S11 family
HPK20_04030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPK20_04035	COG0772	Belongs to the SEDS family
HPK20_04040	COG0768	penicillin binding
HPK20_04045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPK20_04050	COG0799	negative regulation of ribosome biogenesis
HPK20_04055	COG1466	dna polymerase III delta subunit
HPK20_04060	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPK20_04070	COG2888	peptidyl-tyrosine sulfation
HPK20_04075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPK20_04080	COG4535	Mg2 and Co2 transporter CorC
HPK20_04085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPK20_04090	COG1702	phosphate starvation-inducible protein PhoH
HPK20_04095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPK20_04100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPK20_04105	COG2190	(PTS) system
HPK20_04115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_04120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPK20_04125	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPK20_04130	COG3115	cell septum assembly
HPK20_04135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPK20_04150	COG0789	Transcriptional regulator
HPK20_04160	COG0330	HflC and HflK could
HPK20_04165	COG3118	belongs to the thioredoxin family
HPK20_04170	COG0300	oxidoreductase activity
HPK20_04175	COG1090	epimerase
HPK20_04200	COG0622	Phosphoesterase
HPK20_04215	COG3710	Transcriptional regulator
HPK20_04220	COG0326	Molecular chaperone. Has ATPase activity
HPK20_04230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPK20_04235	COG3104	oligopeptide transport
HPK20_04245	COG0367	asparagine synthase
HPK20_04250	COG4651	solute:proton antiporter activity
HPK20_04250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPK20_04255	COG1940	carbohydrate kinase activity
HPK20_04255	COG1846	Transcriptional regulator
HPK20_04260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPK20_04265	COG2190	(PTS) system
HPK20_04265	COG1263	PTS System
HPK20_04265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_04280	COG0101	tRNA pseudouridine synthase activity
HPK20_04285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPK20_04290	COG0285	dihydrofolate synthase activity
HPK20_04295	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPK20_04300	COG1286	toxin biosynthetic process
HPK20_04305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPK20_04310	COG2056	Na+-H+ antiporter family
HPK20_04315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK20_04330	COG0346	lactoylglutathione lyase activity
HPK20_04335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPK20_04340	COG4660	Part of a membrane complex involved in electron transport
HPK20_04345	COG4659	FMN binding
HPK20_04350	COG4658	electron transport chain
HPK20_04355	COG4656	Part of a membrane complex involved in electron transport
HPK20_04365	COG4657	Part of a membrane complex involved in electron transport
HPK20_04370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK20_04385	COG0556	nucleotide-excision repair
HPK20_04390	COG2204	response regulator
HPK20_04395	COG2198	Histidine kinase
HPK20_04400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPK20_04405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPK20_04410	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPK20_04415	COG0315	cyclic pyranopterin monophosphate synthase activity
HPK20_04420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPK20_04425	COG0314	molybdopterin synthase activity
HPK20_04430	COG3706	GGDEF domain
HPK20_04435	COG0617	tRNA 3'-terminal CCA addition
HPK20_04435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPK20_04435	COG0517	IMP dehydrogenase activity
HPK20_04445	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPK20_04455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_04455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_04460	COG0489	protein tyrosine kinase activity
HPK20_04465	COG0572	uridine kinase
HPK20_04470	COG2982	Protein involved in outer membrane biogenesis
HPK20_04475	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPK20_04490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPK20_04515	COG0183	Belongs to the thiolase family
HPK20_04520	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPK20_04520	COG1024	Enoyl-CoA hydratase
HPK20_04525	COG0778	Nitroreductase
HPK20_04530	COG0583	DNA-binding transcription factor activity
HPK20_04535	COG0745	RESPONSE REGULATOR receiver
HPK20_04540	COG2832	Protein of unknown function (DUF454)
HPK20_04545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPK20_04555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPK20_04560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPK20_04565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPK20_04575	COG2983	Belongs to the UPF0260 family
HPK20_04595	COG2226	methyltransferase
HPK20_04605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK20_04610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_04620	COG3139	Protein of unknown function (DUF1315)
HPK20_04625	COG0252	asparaginase activity
HPK20_04630	COG0616	signal peptide processing
HPK20_04635	COG1902	pentaerythritol trinitrate reductase activity
HPK20_04635	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPK20_04640	COG0788	formyltetrahydrofolate deformylase activity
HPK20_04650	COG1199	ATP-dependent helicase activity
HPK20_04655	COG1214	PFAM Peptidase M22, glycoprotease
HPK20_04675	COG0318	PFAM AMP-dependent synthetase and ligase
HPK20_04680	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPK20_04690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPK20_04695	COG2894	cell division
HPK20_04705	COG3100	YcgL domain-containing protein
HPK20_04710	COG2951	lytic endotransglycosylase activity
HPK20_04720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK20_04725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPK20_04735	COG3842	ATPase activity
HPK20_04745	COG1840	ABC-type Fe3 transport system, periplasmic component
HPK20_04750	COG2271	Major facilitator Superfamily
HPK20_04755	COG3851	Histidine kinase
HPK20_04760	COG2197	response regulator
HPK20_04795	COG4589	Belongs to the CDS family
HPK20_04805	COG1716	ATPase activity
HPK20_04805	COG5001	Diguanylate cyclase
HPK20_04815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPK20_04815	COG3153	acetyltransferase
HPK20_04825	COG1760	l-serine dehydratase
HPK20_04830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPK20_04835	COG0745	RESPONSE REGULATOR receiver
HPK20_04850	COG1404	Belongs to the peptidase S8 family
HPK20_04855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPK20_04860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPK20_04865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPK20_04870	COG2204	response regulator
HPK20_04875	COG4191	Histidine kinase
HPK20_04880	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPK20_04890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPK20_04895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPK20_04900	COG0776	regulation of translation
HPK20_04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPK20_04910	COG1555	photosystem II stabilization
HPK20_04915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPK20_04920	COG0539	negative regulation of cytoplasmic translation
HPK20_04930	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPK20_04935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPK20_04955	COG0583	DNA-binding transcription factor activity
HPK20_04965	COG0686	Belongs to the AlaDH PNT family
HPK20_04970	COG1522	sequence-specific DNA binding
HPK20_04975	COG1674	ftsk spoiiie
HPK20_04980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPK20_04985	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPK20_04990	COG2186	Transcriptional regulator
HPK20_05005	COG0537	adenosine 5'-monophosphoramidase activity
HPK20_05035	COG1252	NADH dehydrogenase
HPK20_05050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPK20_05060	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPK20_05065	COG1136	(ABC) transporter
HPK20_05070	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPK20_05080	COG2333	competence protein COMEC
HPK20_05080	COG0658	competence protein
HPK20_05085	COG1132	(ABC) transporter
HPK20_05100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPK20_05105	COG2719	SpoVR family
HPK20_05110	COG2718	Belongs to the UPF0229 family
HPK20_05115	COG2766	serine protein kinase
HPK20_05135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPK20_05150	COG1882	Formate acetyltransferase
HPK20_05175	COG4160	amino acid transport
HPK20_05180	COG0708	Exodeoxyribonuclease III
HPK20_05195	COG3923	Primosomal replication protein n
HPK20_05200	COG1199	ATP-dependent helicase activity
HPK20_05205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPK20_05215	COG3012	SEC-C Motif Domain Protein
HPK20_05220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPK20_05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPK20_05230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPK20_05235	COG0215	cysteine-tRNA ligase activity
HPK20_05240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPK20_05245	COG0632	four-way junction helicase activity
HPK20_05250	COG2255	four-way junction helicase activity
HPK20_05255	COG1271	oxidase subunit
HPK20_05260	COG1294	oxidase, subunit
HPK20_05265	COG4890	Cyd operon protein YbgT
HPK20_05275	COG0824	Thioesterase
HPK20_05280	COG0811	peptide transport
HPK20_05300	COG2885	chlorophyll binding
HPK20_05305	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HPK20_05310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPK20_05320	COG0784	Response regulator, receiver
HPK20_05320	COG5002	protein histidine kinase activity
HPK20_05335	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_05355	COG1960	acyl-CoA dehydrogenase activity
HPK20_05360	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPK20_05375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPK20_05380	COG1979	alcohol dehydrogenase
HPK20_05385	COG1737	Transcriptional regulator
HPK20_05390	COG0076	glutamate decarboxylase activity
HPK20_05400	COG2431	L-lysine efflux transmembrane transporter activity
HPK20_05410	COG3070	regulator of competence-specific genes
HPK20_05425	COG3852	Histidine kinase
HPK20_05435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPK20_05440	COG1032	radical SAM domain protein
HPK20_05445	COG0488	(ABC) transporter
HPK20_05465	COG0745	RESPONSE REGULATOR receiver
HPK20_05470	COG5002	protein histidine kinase activity
HPK20_05475	COG0346	lactoylglutathione lyase activity
HPK20_05480	COG1794	racemase activity, acting on amino acids and derivatives
HPK20_05495	COG0840	transmembrane signaling receptor activity
HPK20_05500	COG2771	luxR family
HPK20_05500	COG2200	EAL domain
HPK20_05510	COG0625	glutathione transferase activity
HPK20_05530	COG0612	Peptidase, M16
HPK20_05545	COG0583	DNA-binding transcription factor activity
HPK20_05550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPK20_05560	COG2350	Protein conserved in bacteria
HPK20_05580	COG1301	dicarboxylic acid transport
HPK20_05590	COG0133	tryptophan synthase activity
HPK20_05595	COG0134	indole-3-glycerol-phosphate synthase activity
HPK20_05595	COG0135	phosphoribosylanthranilate isomerase activity
HPK20_05600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPK20_05605	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK20_05610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK20_05620	COG0613	PHP domain protein
HPK20_05625	COG0009	L-threonylcarbamoyladenylate synthase
HPK20_05630	COG1187	pseudouridine synthase activity
HPK20_05650	COG0739	heme binding
HPK20_05655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPK20_05660	COG4988	ABC transporter
HPK20_05665	COG0492	ferredoxin-NADP+ reductase activity
HPK20_05685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK20_05690	COG1454	alcohol dehydrogenase
HPK20_05700	COG1414	Transcriptional regulator
HPK20_05705	COG1414	Transcriptional regulator
HPK20_05715	COG2949	membrane
HPK20_05740	COG0640	Transcriptional regulator
HPK20_05755	COG0583	DNA-binding transcription factor activity
HPK20_05780	COG0281	malic enzyme
HPK20_05785	COG1643	Atp-dependent helicase
HPK20_05795	COG1757	Na H antiporter
HPK20_05800	COG0174	glutamine synthetase
HPK20_05805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPK20_05810	COG1917	Cupin 2, conserved barrel domain protein
HPK20_05810	COG1396	sequence-specific DNA binding
HPK20_05815	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_05820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPK20_05830	COG2957	Belongs to the agmatine deiminase family
HPK20_05840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK20_05845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPK20_05865	COG2885	chlorophyll binding
HPK20_05880	COG0247	lactate metabolic process
HPK20_05880	COG0277	FAD linked oxidase domain protein
HPK20_05900	COG2986	histidine ammonia-lyase
HPK20_05910	COG0010	Belongs to the arginase family
HPK20_05915	COG1228	amidohydrolase
HPK20_05930	COG3099	Belongs to the UPF0263 family
HPK20_05935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPK20_05945	COG5001	Diguanylate cyclase
HPK20_05950	COG0417	DNA replication proofreading
HPK20_05955	COG2197	response regulator
HPK20_05960	COG0322	excinuclease ABC activity
HPK20_05990	COG2133	pyrroloquinoline quinone binding
HPK20_06010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPK20_06015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPK20_06015	COG0072	phenylalanine-tRNA ligase activity
HPK20_06020	COG0776	regulation of translation
HPK20_06030	COG0500	methyltransferase
HPK20_06060	COG3300	MHYT domain
HPK20_06060	COG5001	Diguanylate cyclase
HPK20_06065	COG0295	cytidine deaminase activity
HPK20_06070	COG1346	cytolysis
HPK20_06075	COG1380	Effector of murein hydrolase LrgA
HPK20_06080	COG2925	Exonuclease
HPK20_06095	COG0702	epimerase
HPK20_06100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPK20_06105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPK20_06110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPK20_06125	COG2988	succinylglutamate desuccinylase activity
HPK20_06130	COG4139	cobalamin transport
HPK20_06135	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPK20_06185	COG0583	DNA-binding transcription factor activity
HPK20_06195	COG1451	nucleotide metabolic process
HPK20_06210	COG3063	Type IV pilus biogenesis stability protein PilW
HPK20_06215	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPK20_06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_06250	COG3290	protein histidine kinase activity
HPK20_06255	COG4565	transcriptional regulatory protein
HPK20_06265	COG0835	chemotaxis
HPK20_06265	COG0784	Response regulator, receiver
HPK20_06325	COG1278	Cold shock
HPK20_06360	COG0668	transmembrane transport
HPK20_06375	COG0745	RESPONSE REGULATOR receiver
HPK20_06380	COG5002	protein histidine kinase activity
HPK20_06425	COG3391	amine dehydrogenase activity
HPK20_06430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPK20_06435	COG1254	Belongs to the acylphosphatase family
HPK20_06440	COG2920	part of a sulfur-relay system
HPK20_06445	COG0670	Belongs to the BI1 family
HPK20_06450	COG1126	abc transporter atp-binding protein
HPK20_06455	COG0765	amino acid transport
HPK20_06460	COG4597	amino acid ABC transporter
HPK20_06465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_06475	COG0561	phosphatase activity
HPK20_06480	COG0602	queuosine metabolic process
HPK20_06490	COG3005	denitrification pathway
HPK20_06495	COG0243	molybdopterin cofactor binding
HPK20_06525	COG2999	glutathione oxidoreductase activity
HPK20_06540	COG3706	GGDEF domain
HPK20_06550	COG3706	GGDEF domain
HPK20_06555	COG0443	Heat shock 70 kDa protein
HPK20_06570	COG3706	GGDEF domain
HPK20_06595	COG3005	denitrification pathway
HPK20_06605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPK20_06610	COG1643	Atp-dependent helicase
HPK20_06620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPK20_06630	COG3501	Rhs element vgr protein
HPK20_06655	COG1115	amino acid carrier protein
HPK20_06670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_06675	COG1666	GTP binding
HPK20_06680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_06685	COG0574	Belongs to the PEP-utilizing enzyme family
HPK20_06685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPK20_06700	COG2996	Protein conserved in bacteria
HPK20_06710	COG3008	intermembrane lipid transfer
HPK20_06715	COG2995	paraquat-inducible protein a
HPK20_06720	COG1132	(ABC) transporter
HPK20_06725	COG1956	GAF domain-containing protein
HPK20_06750	COG0308	aminopeptidase N
HPK20_06765	COG0167	dihydroorotate dehydrogenase activity
HPK20_06775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPK20_06775	COG0116	Belongs to the methyltransferase superfamily
HPK20_06800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPK20_06805	COG1067	ATP-dependent peptidase activity
HPK20_06810	COG3120	sequence-specific DNA binding
HPK20_06830	COG0784	Response regulator, receiver
HPK20_06830	COG2205	protein histidine kinase activity
HPK20_06845	COG3278	Belongs to the heme-copper respiratory oxidase family
HPK20_06860	COG2010	Cytochrome c
HPK20_06870	COG2217	Heavy metal translocating P-type atpase
HPK20_06885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK20_06890	COG0589	response to stress
HPK20_06915	COG3842	ATPase activity
HPK20_06925	COG1177	transmembrane transport
HPK20_06935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK20_06940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPK20_06945	COG0004	ammonium transporteR
HPK20_06960	COG0437	4 iron, 4 sulfur cluster binding
HPK20_06965	COG3383	formate dehydrogenase (NAD+) activity
HPK20_06965	COG0243	molybdopterin cofactor binding
HPK20_06975	COG3381	protein complex oligomerization
HPK20_06995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK20_07010	COG3852	Histidine kinase
HPK20_07015	COG2204	response regulator
HPK20_07025	COG4662	Binding-protein-dependent transport system inner membrane component
HPK20_07030	COG3842	ATPase activity
HPK20_07035	COG0746	molybdenum cofactor guanylyltransferase activity
HPK20_07040	COG0303	'Molybdopterin
HPK20_07050	COG1940	carbohydrate kinase activity
HPK20_07065	COG0840	transmembrane signaling receptor activity
HPK20_07070	COG0791	NLP P60 protein
HPK20_07080	COG3001	Fructosamine kinase
HPK20_07090	COG0307	riboflavin synthase, alpha
HPK20_07105	COG1793	dna ligase
HPK20_07110	COG4667	esterase of the alpha-beta hydrolase superfamily
HPK20_07130	COG0848	biopolymer transport protein
HPK20_07135	COG0811	peptide transport
HPK20_07140	COG0811	peptide transport
HPK20_07150	COG3040	lipid binding
HPK20_07155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK20_07160	COG0039	L-malate dehydrogenase activity
HPK20_07165	COG1653	transport
HPK20_07175	COG0395	ABC-type sugar transport system, permease component
HPK20_07180	COG3842	ATPase activity
HPK20_07185	COG1349	DNA-binding transcription factor activity
HPK20_07190	COG0584	glycerophosphoryl diester phosphodiesterase
HPK20_07195	COG2731	YhcH YjgK YiaL family protein
HPK20_07215	COG0625	glutathione transferase activity
HPK20_07225	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPK20_07235	COG2200	EAL domain
HPK20_07240	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK20_07255	COG2814	Major facilitator Superfamily
HPK20_07260	COG1566	PFAM secretion protein HlyD family protein
HPK20_07275	COG2828	Protein conserved in bacteria
HPK20_07280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPK20_07285	COG0372	Belongs to the citrate synthase family
HPK20_07290	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPK20_07300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK20_07300	COG2169	Transcriptional regulator
HPK20_07335	COG1129	ABC transporter
HPK20_07345	COG3250	beta-galactosidase activity
HPK20_07355	COG2991	Protein conserved in bacteria
HPK20_07360	COG0778	Nitroreductase
HPK20_07365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPK20_07370	COG0583	DNA-binding transcription factor activity
HPK20_07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_07380	COG4191	Histidine kinase
HPK20_07385	COG0471	metal ion transport
HPK20_07405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK20_07415	COG3768	UPF0283 membrane protein
HPK20_07420	COG3106	COG3106 Predicted ATPase
HPK20_07435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK20_07450	COG0494	nUDIX hydrolase
HPK20_07455	COG0814	amino acid
HPK20_07460	COG1760	l-serine dehydratase
HPK20_07465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_07470	COG0577	efflux transmembrane transporter activity
HPK20_07470	COG1136	(ABC) transporter
HPK20_07480	COG0720	synthase
HPK20_07485	COG0840	transmembrane signaling receptor activity
HPK20_07490	COG0017	Asparaginyl-tRNA synthetase
HPK20_07510	COG1448	Aminotransferase
HPK20_07520	COG0517	IMP dehydrogenase activity
HPK20_07525	COG2176	DNA-directed DNA polymerase activity
HPK20_07530	COG0840	transmembrane signaling receptor activity
HPK20_07535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPK20_07540	COG1846	Transcriptional regulator
HPK20_07545	COG2197	response regulator
HPK20_07560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_07575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPK20_07580	COG3108	Peptidase M15
HPK20_07585	COG2989	Protein conserved in bacteria
HPK20_07610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPK20_07625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK20_07630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPK20_07660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPK20_07665	COG3265	gluconokinase activity
HPK20_07680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_07730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPK20_07745	COG4181	ATPase activity
HPK20_07750	COG0534	Mate efflux family protein
HPK20_07755	COG0702	epimerase
HPK20_07765	COG2814	Major facilitator Superfamily
HPK20_07775	COG1061	Type III restriction enzyme res subunit
HPK20_07785	COG0745	RESPONSE REGULATOR receiver
HPK20_07790	COG2205	protein histidine kinase activity
HPK20_07795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPK20_07830	COG0714	Associated with various cellular activities
HPK20_07835	COG0641	radical SAM
HPK20_07840	COG3119	arylsulfatase activity
HPK20_07850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPK20_07860	COG1278	Cold shock
HPK20_07870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPK20_07875	COG3706	GGDEF domain
HPK20_07890	COG0814	amino acid
HPK20_07900	COG1131	(ABC) transporter
HPK20_07905	COG0842	Transport permease protein
HPK20_07915	COG3313	Fe-S protein
HPK20_07925	COG4134	Bacterial extracellular solute-binding protein
HPK20_07930	COG4135	transport system, permease component
HPK20_07935	COG4136	ATPase activity
HPK20_07940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPK20_07945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPK20_07955	COG0564	pseudouridine synthase activity
HPK20_07975	COG0733	neurotransmitter:sodium symporter activity
HPK20_07985	COG0626	cystathionine gamma-synthase activity
HPK20_08015	COG0519	Catalyzes the synthesis of GMP from XMP
HPK20_08030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_08045	COG1842	Phage shock protein A
HPK20_08050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPK20_08060	COG4168	peptide transport system, permease
HPK20_08065	COG4171	peptide transport system, permease
HPK20_08075	COG4172	Belongs to the ABC transporter superfamily
HPK20_08090	COG1227	inorganic diphosphatase activity
HPK20_08110	COG0243	molybdopterin cofactor binding
HPK20_08115	COG3005	denitrification pathway
HPK20_08120	COG4459	periplasmic nitrate reductase
HPK20_08125	COG0390	transport system, permease component
HPK20_08130	COG2116	formate transmembrane transporter activity
HPK20_08150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK20_08155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPK20_08160	COG1435	thymidine kinase activity
HPK20_08175	COG4106	trans-aconitate 2-methyltransferase activity
HPK20_08180	COG0500	methyltransferase
HPK20_08185	COG0189	ligase activity
HPK20_08185	COG4067	protein conserved in archaea
HPK20_08195	COG0189	ligase activity
HPK20_08200	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HPK20_08205	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPK20_08210	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPK20_08215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK20_08220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPK20_08225	COG0745	RESPONSE REGULATOR receiver
HPK20_08230	COG3381	protein complex oligomerization
HPK20_08235	COG1609	Transcriptional regulator
HPK20_08240	COG3070	regulator of competence-specific genes
HPK20_08260	COG0297	glycogen (starch) synthase activity
HPK20_08265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPK20_08275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK20_08295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPK20_08300	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPK20_08305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPK20_08310	COG0542	response to heat
HPK20_08315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPK20_08320	COG1278	Cold shock
HPK20_08330	COG1187	pseudouridine synthase activity
HPK20_08335	COG0140	phosphoribosyl-ATP diphosphatase activity
HPK20_08335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPK20_08345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPK20_08350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPK20_08355	COG0131	Imidazoleglycerol-phosphate dehydratase
HPK20_08355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPK20_08360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPK20_08365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPK20_08370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPK20_08380	COG1757	Na H antiporter
HPK20_08385	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPK20_08390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_08395	COG0482	sulfurtransferase activity
HPK20_08400	COG2915	High frequency lysogenization protein hflD homolog
HPK20_08405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPK20_08425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPK20_08440	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_08450	COG0501	Belongs to the peptidase M48B family
HPK20_08460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPK20_08465	COG2226	methyltransferase
HPK20_08475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPK20_08480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPK20_08490	COG2146	nitrite reductase [NAD(P)H] activity
HPK20_08490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK20_08495	COG1116	anion transmembrane transporter activity
HPK20_08500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK20_08505	COG1116	anion transmembrane transporter activity
HPK20_08505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPK20_08520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK20_08520	COG1648	precorrin-2 dehydrogenase activity
HPK20_08525	COG0243	molybdopterin cofactor binding
HPK20_08535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPK20_08540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPK20_08545	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPK20_08550	COG0653	protein targeting
HPK20_08565	COG3706	GGDEF domain
HPK20_08575	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPK20_08585	COG3092	negative regulation of chromosome organization
HPK20_08590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPK20_08595	COG0280	phosphate acetyltransferase
HPK20_08595	COG0857	belongs to the CobB CobQ family
HPK20_08600	COG3174	membrane
HPK20_08605	COG0435	Glutathione S-transferase
HPK20_08620	COG0444	Belongs to the ABC transporter superfamily
HPK20_08625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_08630	COG0601	transmembrane transport
HPK20_08660	COG0204	Acyl-transferase
HPK20_08660	COG0318	PFAM AMP-dependent synthetase and ligase
HPK20_08665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK20_08670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPK20_08680	COG0318	PFAM AMP-dependent synthetase and ligase
HPK20_08690	COG1216	Glycosyl transferase, family 2
HPK20_08695	COG2986	histidine ammonia-lyase
HPK20_08730	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_08745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_08755	COG2202	Pas domain
HPK20_08755	COG2200	EAL domain
HPK20_08755	COG2199	diguanylate cyclase activity
HPK20_08760	COG1621	beta-fructofuranosidase activity
HPK20_08770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_08770	COG1263	PTS System
HPK20_08780	COG0745	RESPONSE REGULATOR receiver
HPK20_08790	COG3708	Transcriptional regulator
HPK20_08790	COG2207	Transcriptional regulator
HPK20_08795	COG2814	Major facilitator Superfamily
HPK20_08800	COG1566	PFAM secretion protein HlyD family protein
HPK20_08805	COG1538	Outer membrane efflux protein
HPK20_08815	COG0747	negative chemotaxis
HPK20_08820	COG0601	transmembrane transport
HPK20_08825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_08830	COG4172	Belongs to the ABC transporter superfamily
HPK20_08835	COG0351	phosphomethylpyrimidine kinase
HPK20_08845	COG0352	thiamine-phosphate diphosphorylase activity
HPK20_08850	COG1741	Belongs to the pirin family
HPK20_08855	COG2723	6-phospho-beta-galactosidase activity
HPK20_08860	COG1609	Transcriptional regulator
HPK20_08870	COG1120	ATPase activity
HPK20_08875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPK20_08885	COG1629	transport
HPK20_08885	COG4774	siderophore transport
HPK20_08890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_08895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_08900	COG4592	Periplasmic binding protein
HPK20_08915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPK20_08915	COG3433	isochorismatase activity
HPK20_08915	COG2226	methyltransferase
HPK20_08920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_08925	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_08930	COG1169	isochorismate synthase
HPK20_08935	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPK20_08945	COG2814	Major facilitator Superfamily
HPK20_08950	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPK20_08990	COG1294	oxidase, subunit
HPK20_08995	COG1271	oxidase subunit
HPK20_09000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_09015	COG3258	Cytochrome c
HPK20_09020	COG2863	cytochrome
HPK20_09065	COG2194	sulfuric ester hydrolase activity
HPK20_09070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK20_09075	COG1368	sulfuric ester hydrolase activity
HPK20_09080	COG0513	Belongs to the DEAD box helicase family
HPK20_09090	COG0671	phosphoesterase, PA-phosphatase related
HPK20_09100	COG0642	Histidine kinase
HPK20_09115	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPK20_09120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPK20_09150	COG2207	Transcriptional regulator
HPK20_09155	COG1881	PFAM PEBP family protein
HPK20_09160	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPK20_09165	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPK20_09165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPK20_09170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_09175	COG2207	Transcriptional regulator
HPK20_09200	COG1278	Cold shock
HPK20_09210	COG0697	spore germination
HPK20_09215	COG0431	NADPH-dependent FMN reductase
HPK20_09230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPK20_09255	COG1073	alpha beta
HPK20_09260	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_09270	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_09280	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_09285	COG4221	oxidoreductase activity
HPK20_09305	COG1309	transcriptional regulator
HPK20_09325	COG2199	diguanylate cyclase activity
HPK20_09325	COG2203	Gaf domain
HPK20_09340	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HPK20_09345	COG1946	Acyl-CoA thioesterase
HPK20_09350	COG1522	sequence-specific DNA binding
HPK20_09395	COG2885	chlorophyll binding
HPK20_09425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPK20_09440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_09445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPK20_09465	COG1580	Controls the rotational direction of flagella during chemotaxis
HPK20_09470	COG1191	sigma factor activity
HPK20_09475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPK20_09480	COG1360	Flagellar Motor Protein
HPK20_09490	COG3015	lipoprotein NlpE involved in copper resistance
HPK20_09495	COG0702	epimerase
HPK20_09525	COG4786	Flagellar basal body rod
HPK20_09525	COG1256	bacterial-type flagellum assembly
HPK20_09535	COG1706	bacterial-type flagellum-dependent cell motility
HPK20_09540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPK20_09545	COG4786	Flagellar basal body rod
HPK20_09555	COG1749	Flagellar hook protein flgE
HPK20_09560	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPK20_09565	COG1558	bacterial-type flagellum-dependent cell motility
HPK20_09570	COG1815	bacterial-type flagellum-dependent cell motility
HPK20_09590	COG1388	LysM domain
HPK20_09590	COG0741	lytic transglycosylase activity
HPK20_09595	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPK20_09615	COG0477	Major facilitator Superfamily
HPK20_09620	COG2855	membrane
HPK20_09640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPK20_09645	COG0596	Alpha beta hydrolase
HPK20_09650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPK20_09655	COG1169	isochorismate synthase
HPK20_09660	COG0436	Aminotransferase
HPK20_09665	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPK20_09670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPK20_09715	COG0616	signal peptide processing
HPK20_09720	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_09735	COG0587	DNA-directed DNA polymerase activity
HPK20_09740	COG0784	Response regulator, receiver
HPK20_09740	COG0835	chemotaxis
HPK20_09745	COG1940	carbohydrate kinase activity
HPK20_09750	COG0469	pyruvate kinase activity
HPK20_09755	COG4667	esterase of the alpha-beta hydrolase superfamily
HPK20_09770	COG0733	neurotransmitter:sodium symporter activity
HPK20_09785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_09785	COG1263	PTS System
HPK20_09795	COG1263	PTS System
HPK20_09795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPK20_09795	COG2190	(PTS) system
HPK20_09800	COG0084	hydrolase, TatD family'
HPK20_09805	COG0470	DNA polymerase III
HPK20_09810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPK20_09815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPK20_09820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPK20_09825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK20_09845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK20_09850	COG0416	fatty acid biosynthetic process
HPK20_09855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPK20_09860	COG1399	metal-binding, possibly nucleic acid-binding protein
HPK20_09865	COG0424	maF-like protein
HPK20_09870	COG0564	pseudouridine synthase activity
HPK20_09875	COG1530	ribonuclease E activity
HPK20_09885	COG0659	secondary active sulfate transmembrane transporter activity
HPK20_09895	COG1454	alcohol dehydrogenase
HPK20_09895	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_09900	COG2095	MarC family integral membrane protein
HPK20_09905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK20_09910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPK20_09915	COG1757	Na H antiporter
HPK20_09930	COG3081	Nucleoid-associated protein
HPK20_09935	COG3082	Protein of unknown function (DUF1414)
HPK20_09940	COG3083	sulfuric ester hydrolase activity
HPK20_09965	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPK20_09980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPK20_10020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK20_10025	COG2159	amidohydrolase
HPK20_10030	COG0583	DNA-binding transcription factor activity
HPK20_10045	COG0667	Aldo Keto reductase
HPK20_10070	COG3384	dioxygenase
HPK20_10075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPK20_10080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPK20_10100	COG2853	Lipoprotein
HPK20_10115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPK20_10120	COG1138	Cytochrome C-type biogenesis protein
HPK20_10125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPK20_10130	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK20_10135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK20_10140	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPK20_10145	COG4133	protoheme IX ABC transporter activity
HPK20_10155	COG0835	chemotaxis
HPK20_10165	COG1192	Involved in chromosome partitioning
HPK20_10170	COG2201	protein-glutamate methylesterase activity
HPK20_10175	COG0643	Histidine kinase
HPK20_10175	COG2198	Histidine kinase
HPK20_10175	COG0784	Response regulator, receiver
HPK20_10180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPK20_10210	COG2062	phosphohistidine phosphatase, SixA
HPK20_10220	COG3102	Protein conserved in bacteria
HPK20_10225	COG0018	arginyl-trna synthetase
HPK20_10245	COG1918	ferrous iron import across plasma membrane
HPK20_10255	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPK20_10260	COG1121	(ABC) transporter
HPK20_10265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPK20_10280	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPK20_10285	COG0567	Dehydrogenase, E1 component
HPK20_10300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPK20_10315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPK20_10325	COG0033	Phosphoglucomutase
HPK20_10330	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPK20_10335	COG0596	Alpha beta hydrolase
HPK20_10350	COG1346	cytolysis
HPK20_10355	COG1380	Effector of murein hydrolase LrgA
HPK20_10360	COG0583	DNA-binding transcription factor activity
HPK20_10370	COG0735	belongs to the Fur family
HPK20_10375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPK20_10380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_10385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPK20_10390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPK20_10390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPK20_10405	COG3101	peptidyl-lysine hydroxylation
HPK20_10410	COG2860	membrane
HPK20_10415	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_10420	COG0583	DNA-binding transcription factor activity
HPK20_10425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPK20_10430	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK20_10435	COG2840	Smr protein MutS2
HPK20_10450	COG1987	bacterial-type flagellum assembly
HPK20_10500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPK20_10510	COG1677	Flagellar hook-basal body complex protein FliE
HPK20_10520	COG4191	Histidine kinase
HPK20_10530	COG1516	flagellar protein fliS
HPK20_10540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPK20_10545	COG1334	flagellar protein FlaG
HPK20_10550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_10555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_10565	COG2837	iron assimilation
HPK20_10585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPK20_10595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK20_10605	COG1393	Belongs to the ArsC family
HPK20_10615	COG1876	peptidase activity
HPK20_10625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPK20_10635	COG2716	regulation of RNA biosynthetic process
HPK20_10665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK20_10685	COG3550	peptidyl-serine autophosphorylation
HPK20_10725	COG3621	Patatin-like phospholipase
HPK20_10730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPK20_10740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPK20_10760	COG4783	chaperone-mediated protein folding
HPK20_10765	COG1393	Belongs to the ArsC family
HPK20_10785	COG2233	PERMEase
HPK20_10795	COG0737	Belongs to the 5'-nucleotidase family
HPK20_10800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPK20_10805	COG2912	Transglutaminase-like superfamily
HPK20_10815	COG2890	protein-(glutamine-N5) methyltransferase activity
HPK20_10820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPK20_10825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPK20_10830	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPK20_10840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPK20_10845	COG0193	aminoacyl-tRNA hydrolase activity
HPK20_10945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPK20_10965	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPK20_10965	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPK20_10970	COG1706	bacterial-type flagellum-dependent cell motility
HPK20_10975	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPK20_10985	COG4787	bacterial-type flagellum-dependent cell motility
HPK20_11005	COG1815	bacterial-type flagellum-dependent cell motility
HPK20_11010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPK20_11015	COG0835	chemotaxis
HPK20_11015	COG0784	Response regulator, receiver
HPK20_11025	COG2747	anti-sigma28 factor FlgM
HPK20_11060	COG2194	sulfuric ester hydrolase activity
HPK20_11065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK20_11085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPK20_11090	COG2217	Heavy metal translocating P-type atpase
HPK20_11090	COG2608	mercury ion transmembrane transporter activity
HPK20_11120	COG2840	Smr protein MutS2
HPK20_11125	COG1187	pseudouridine synthase activity
HPK20_11130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPK20_11135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPK20_11140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPK20_11145	COG0121	glutamine amidotransferase
HPK20_11150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPK20_11155	COG1960	acyl-CoA dehydrogenase activity
HPK20_11165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPK20_11170	COG0328	RNA-DNA hybrid ribonuclease activity
HPK20_11175	COG2226	methyltransferase
HPK20_11185	COG1388	LysM domain
HPK20_11185	COG0741	lytic transglycosylase activity
HPK20_11195	COG3021	interspecies interaction between organisms
HPK20_11200	COG0347	Belongs to the P(II) protein family
HPK20_11210	COG0037	tRNA processing
HPK20_11215	COG0825	malonyl-CoA metabolic process
HPK20_11220	COG0587	DNA-directed DNA polymerase activity
HPK20_11225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPK20_11240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPK20_11245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPK20_11250	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPK20_11260	COG0750	zinc metalloprotease
HPK20_11265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPK20_11270	COG0575	Belongs to the CDS family
HPK20_11275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPK20_11290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPK20_11295	COG0052	Belongs to the universal ribosomal protein uS2 family
HPK20_11300	COG0024	Methionine aminopeptidase
HPK20_11305	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPK20_11315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPK20_11320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPK20_11325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPK20_11330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPK20_11345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK20_11345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPK20_11350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPK20_11355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPK20_11360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPK20_11375	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPK20_11380	COG2252	PERMEase
HPK20_11385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPK20_11395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPK20_11405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK20_11410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_11415	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK20_11420	COG0189	ligase activity
HPK20_11420	COG4067	protein conserved in archaea
HPK20_11425	COG0189	ligase activity
HPK20_11435	COG0733	neurotransmitter:sodium symporter activity
HPK20_11440	COG5001	Diguanylate cyclase
HPK20_11440	COG2203	Gaf domain
HPK20_11440	COG3706	GGDEF domain
HPK20_11440	COG4251	negative regulation of phosphorylation
HPK20_11450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPK20_11465	COG1477	protein flavinylation
HPK20_11470	COG2871	sodium ion transport
HPK20_11475	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPK20_11480	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPK20_11490	COG1805	sodium ion transport
HPK20_11495	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPK20_11500	COG0271	Belongs to the BolA IbaG family
HPK20_11585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPK20_11590	COG0590	tRNA wobble adenosine to inosine editing
HPK20_11600	COG0542	response to heat
HPK20_11610	COG0564	pseudouridine synthase activity
HPK20_11615	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPK20_11620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPK20_11625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPK20_11630	COG0077	Prephenate dehydratase
HPK20_11630	COG1605	Chorismate mutase
HPK20_11635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK20_11640	COG5001	Diguanylate cyclase
HPK20_11645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HPK20_11650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPK20_11660	COG0488	(ABC) transporter
HPK20_11670	COG1605	Chorismate mutase
HPK20_11670	COG0287	Prephenate dehydrogenase
HPK20_11675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_11680	COG3275	phosphorelay sensor kinase activity
HPK20_11685	COG3279	Response regulator of the LytR AlgR family
HPK20_11695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPK20_11700	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPK20_11715	COG1966	Carbon starvation protein
HPK20_11720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPK20_11725	COG1047	Peptidyl-prolyl cis-trans
HPK20_11730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPK20_11735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPK20_11740	COG0196	riboflavin kinase activity
HPK20_11745	COG0728	peptidoglycan biosynthetic process
HPK20_11750	COG0268	Binds directly to 16S ribosomal RNA
HPK20_11755	COG0640	Transcriptional regulator
HPK20_11760	COG0583	DNA-binding transcription factor activity
HPK20_11765	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPK20_11770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPK20_11780	COG0730	response to heat
HPK20_11790	COG0494	nUDIX hydrolase
HPK20_11805	COG0667	Aldo Keto reductase
HPK20_11815	COG2204	response regulator
HPK20_11820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPK20_11840	COG0513	Belongs to the DEAD box helicase family
HPK20_11865	COG3153	acetyltransferase
HPK20_11870	COG3154	lipid carrier protein
HPK20_11880	COG0826	peptidase U32
HPK20_11885	COG0826	peptidase U32
HPK20_11890	COG0534	Mate efflux family protein
HPK20_11910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPK20_11915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPK20_11920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPK20_11930	COG0195	Participates in both transcription termination and antitermination
HPK20_11935	COG0779	Required for maturation of 30S ribosomal subunits
HPK20_11950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPK20_11955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK20_11960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPK20_11965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPK20_11970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPK20_11975	COG1534	Rna-binding protein
HPK20_11980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPK20_11985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPK20_11990	COG2027	D-alanyl-D-alanine carboxypeptidase
HPK20_11995	COG2239	Acts as a magnesium transporter
HPK20_12005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPK20_12010	COG0739	heme binding
HPK20_12025	COG0316	Belongs to the HesB IscA family
HPK20_12030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPK20_12040	COG0628	permease
HPK20_12050	COG2205	protein histidine kinase activity
HPK20_12050	COG0784	Response regulator, receiver
HPK20_12055	COG0747	negative chemotaxis
HPK20_12065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPK20_12070	COG0444	Belongs to the ABC transporter superfamily
HPK20_12075	COG4608	Belongs to the ABC transporter superfamily
HPK20_12085	COG2971	BadF BadG BcrA BcrD
HPK20_12100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK20_12105	COG3842	ATPase activity
HPK20_12115	COG1840	ABC-type Fe3 transport system, periplasmic component
HPK20_12120	COG0004	ammonium transporteR
HPK20_12125	COG0347	Belongs to the P(II) protein family
HPK20_12130	COG3112	Uncharacterised protein family (UPF0231)
HPK20_12135	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPK20_12140	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPK20_12145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK20_12150	COG1643	Atp-dependent helicase
HPK20_12155	COG1489	DNA binding
HPK20_12160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPK20_12165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPK20_12175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPK20_12180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPK20_12185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPK20_12190	COG0842	Transport permease protein
HPK20_12195	COG1131	(ABC) transporter
HPK20_12200	COG0288	reversible hydration of carbon dioxide
HPK20_12215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK20_12220	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPK20_12225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPK20_12230	COG2186	Transcriptional regulator
HPK20_12235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPK20_12240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPK20_12245	COG4974	Belongs to the 'phage' integrase family
HPK20_12270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK20_12275	COG1459	type II secretion system
HPK20_12290	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPK20_12305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPK20_12315	COG3150	esterase
HPK20_12325	COG3151	Protein conserved in bacteria
HPK20_12330	COG0494	nUDIX hydrolase
HPK20_12335	COG1538	Outer membrane efflux protein
HPK20_12345	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPK20_12345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPK20_12350	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPK20_12360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPK20_12365	COG3025	triphosphatase activity
HPK20_12370	COG1392	Phosphate transport regulator
HPK20_12375	COG0306	phosphate transporter
HPK20_12380	COG4991	sh3 domain protein
HPK20_12390	COG3267	Type II secretory pathway component ExeA
HPK20_12390	COG3409	Peptidoglycan-binding domain 1 protein
HPK20_12395	COG0617	tRNA 3'-terminal CCA addition
HPK20_12400	COG0148	phosphopyruvate hydratase activity
HPK20_12405	COG0504	CTP synthase activity
HPK20_12410	COG3956	TIGRFAM MazG family protein
HPK20_12415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPK20_12420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK20_12430	COG0736	holo-[acyl-carrier-protein] synthase activity
HPK20_12435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPK20_12440	COG1381	Involved in DNA repair and RecF pathway recombination
HPK20_12445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPK20_12450	COG0571	ribonuclease III activity
HPK20_12460	COG0481	GTPase activity
HPK20_12465	COG3086	response to oxidative stress
HPK20_12480	COG1595	DNA-templated transcription, initiation
HPK20_12485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPK20_12495	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPK20_12515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPK20_12520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPK20_12525	COG3079	Belongs to the UPF0149 family
HPK20_12530	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPK20_12540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPK20_12550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_12555	COG0440	acetolactate synthase activity
HPK20_12560	COG0028	Belongs to the TPP enzyme family
HPK20_12565	COG1022	Amp-dependent synthetase and ligase
HPK20_12570	COG0583	DNA-binding transcription factor activity
HPK20_12595	COG0473	3-isopropylmalate dehydrogenase activity
HPK20_12600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPK20_12650	COG3437	response regulator, receiver
HPK20_12660	COG2203	Gaf domain
HPK20_12660	COG2200	EAL domain
HPK20_12660	COG2199	diguanylate cyclase activity
HPK20_12765	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPK20_12825	COG3706	GGDEF domain
HPK20_12835	COG0795	lipopolysaccharide-transporting ATPase activity
HPK20_12840	COG0795	lipopolysaccharide-transporting ATPase activity
HPK20_12845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPK20_12855	COG0525	valine-tRNA ligase activity
HPK20_12860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK20_12865	COG0564	pseudouridine synthase activity
HPK20_12875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPK20_12880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPK20_12885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPK20_12890	COG0540	Belongs to the ATCase OTCase family
HPK20_12900	COG0251	oxidation-reduction process
HPK20_12905	COG0204	Acyl-transferase
HPK20_12910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPK20_12915	COG5007	Belongs to the BolA IbaG family
HPK20_12920	COG3113	response to antibiotic
HPK20_12925	COG2854	intermembrane phospholipid transfer
HPK20_12930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPK20_12935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPK20_12940	COG1127	ABC transporter
HPK20_12950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPK20_12950	COG0517	IMP dehydrogenase activity
HPK20_12955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPK20_12965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPK20_12970	COG1137	ATPase activity
HPK20_12980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPK20_12985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_12990	COG1660	Displays ATPase and GTPase activities
HPK20_12995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_13000	COG2239	Acts as a magnesium transporter
HPK20_13005	COG0312	modulator of DNA gyrase
HPK20_13010	COG3028	Belongs to the UPF0307 family
HPK20_13015	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPK20_13020	COG1178	ABC-type Fe3 transport system permease component
HPK20_13030	COG0163	prenyltransferase activity
HPK20_13035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPK20_13040	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPK20_13045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPK20_13050	COG2105	PFAM AIG2 family protein
HPK20_13060	COG0729	surface antigen
HPK20_13065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_13070	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPK20_13085	COG1136	(ABC) transporter
HPK20_13085	COG0577	efflux transmembrane transporter activity
HPK20_13105	COG0529	Catalyzes the synthesis of activated sulfate
HPK20_13110	COG0471	metal ion transport
HPK20_13110	COG0490	domain, Protein
HPK20_13115	COG2895	sulfate adenylyltransferase (ATP) activity
HPK20_13120	COG0175	sulfate reduction
HPK20_13125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK20_13125	COG1648	precorrin-2 dehydrogenase activity
HPK20_13130	COG0737	Belongs to the 5'-nucleotidase family
HPK20_13140	COG0513	Belongs to the DEAD box helicase family
HPK20_13145	COG2153	protein acetylation
HPK20_13150	COG0697	spore germination
HPK20_13155	COG3061	Opacity-associated protein A
HPK20_13160	COG0545	Peptidyl-prolyl cis-trans isomerase
HPK20_13170	COG0203	ribosomal protein L17
HPK20_13175	COG0202	RNA polymerase activity
HPK20_13180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPK20_13185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPK20_13190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPK20_13195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPK20_13200	COG0201	protein transport
HPK20_13210	COG1841	ribosomal large subunit assembly
HPK20_13220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPK20_13230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPK20_13235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPK20_13240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPK20_13245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPK20_13250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPK20_13255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPK20_13260	COG0255	Belongs to the universal ribosomal protein uL29 family
HPK20_13265	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPK20_13275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPK20_13280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPK20_13285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPK20_13290	COG0089	rRNA binding
HPK20_13295	COG0088	Forms part of the polypeptide exit tunnel
HPK20_13300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPK20_13305	COG0051	transcription antitermination factor activity, RNA binding
HPK20_13310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK20_13315	COG0557	exoribonuclease II activity
HPK20_13320	COG3083	sulfuric ester hydrolase activity
HPK20_13325	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPK20_13330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPK20_13340	COG1047	Peptidyl-prolyl cis-trans
HPK20_13345	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HPK20_13355	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPK20_13360	COG0488	(ABC) transporter
HPK20_13370	COG0429	hydrolase of the alpha beta-hydrolase fold
HPK20_13380	COG3954	Phosphoribulokinase
HPK20_13395	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_13405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPK20_13415	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPK20_13425	COG0180	Tryptophanyl-tRNA synthetase
HPK20_13435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPK20_13440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPK20_13450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPK20_13485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPK20_13495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPK20_13495	COG0678	peroxiredoxin activity
HPK20_13505	COG0165	Argininosuccinate lyase
HPK20_13505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPK20_13510	COG0137	argininosuccinate synthase activity
HPK20_13515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPK20_13520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPK20_13525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPK20_13530	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPK20_13535	COG1695	Transcriptional regulator
HPK20_13540	COG1045	serine acetyltransferase
HPK20_13545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPK20_13550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPK20_13555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_13560	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPK20_13565	COG1053	succinate dehydrogenase
HPK20_13570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPK20_13575	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPK20_13585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPK20_13590	COG1509	lysine 2,3-aminomutase activity
HPK20_13595	COG1285	pathogenesis
HPK20_13605	COG1119	ATPase activity
HPK20_13610	COG0459	protein refolding
HPK20_13640	COG0149	triose-phosphate isomerase activity
HPK20_13645	COG0534	Mate efflux family protein
HPK20_13650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPK20_13655	COG1575	Belongs to the MenA family. Type 1 subfamily
HPK20_13660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPK20_13665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPK20_13675	COG1609	Transcriptional regulator
HPK20_13680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPK20_13685	COG0254	rRNA binding
HPK20_13690	COG0281	malic enzyme
HPK20_13695	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPK20_13700	COG0626	cystathionine gamma-synthase activity
HPK20_13705	COG0527	aspartate kinase activity
HPK20_13705	COG0460	homoserine dehydrogenase
HPK20_13710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPK20_13720	COG1494	fructose-1,6-bisphosphatase
HPK20_13725	COG0205	6-phosphofructokinase activity
HPK20_13730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPK20_13740	COG0745	RESPONSE REGULATOR receiver
HPK20_13745	COG2205	protein histidine kinase activity
HPK20_13750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPK20_13755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPK20_13760	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPK20_13765	COG3706	GGDEF domain
HPK20_13770	COG1027	Aspartate ammonia-lyase
HPK20_13775	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPK20_13780	COG1288	antiporter activity
HPK20_13795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPK20_13800	COG0540	Belongs to the ATCase OTCase family
HPK20_13805	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HPK20_13815	COG4232	protein-disulfide reductase activity
HPK20_13835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK20_13840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPK20_13845	COG0194	GDP metabolic process
HPK20_13850	COG1758	RNA polymerase activity
HPK20_13855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPK20_13860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPK20_13865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPK20_13870	COG2233	PERMEase
HPK20_13875	COG2205	protein histidine kinase activity
HPK20_13880	COG0745	RESPONSE REGULATOR receiver
HPK20_13885	COG0800	Aldolase
HPK20_13890	COG2610	gluconate transmembrane transporter activity
HPK20_13895	COG3265	gluconokinase activity
HPK20_13900	COG0129	dihydroxy-acid dehydratase activity
HPK20_13905	COG1609	Transcriptional regulator
HPK20_13910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPK20_13920	COG2183	response to ionizing radiation
HPK20_13935	COG1040	competence protein
HPK20_13945	COG0494	nUDIX hydrolase
HPK20_13950	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPK20_13960	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPK20_13965	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPK20_13970	COG3156	type II secretion system protein K
HPK20_13975	COG4795	General secretion pathway protein
HPK20_13980	COG2165	general secretion pathway protein
HPK20_13985	COG2165	general secretion pathway protein
HPK20_13990	COG2165	general secretion pathway protein
HPK20_13995	COG1459	type II secretion system
HPK20_14000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPK20_14010	COG3031	protein transport across the cell outer membrane
HPK20_14015	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPK20_14020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPK20_14030	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPK20_14035	COG2982	Protein involved in outer membrane biogenesis
HPK20_14040	COG0456	acetyltransferase
HPK20_14045	COG1490	D-aminoacyl-tRNA deacylase activity
HPK20_14070	COG0174	glutamine synthetase
HPK20_14080	COG3852	Histidine kinase
HPK20_14085	COG2204	response regulator
HPK20_14090	COG3300	MHYT domain
HPK20_14090	COG5001	Diguanylate cyclase
HPK20_14095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPK20_14155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPK20_14170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK20_14185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPK20_14190	COG0534	Mate efflux family protein
HPK20_14200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPK20_14205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPK20_14210	COG2937	Belongs to the GPAT DAPAT family
HPK20_14215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPK20_14220	COG3161	chorismate lyase activity
HPK20_14225	COG1580	Controls the rotational direction of flagella during chemotaxis
HPK20_14230	COG0705	Rhomboid family
HPK20_14235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_14240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPK20_14245	COG2177	Part of the ABC transporter FtsEX involved in
HPK20_14250	COG2884	Cell division ATP-binding protein ftsE
HPK20_14255	COG0552	protein localization to endoplasmic reticulum
HPK20_14260	COG0742	ribosomal rna small subunit methyltransferase
HPK20_14270	COG2095	MarC family integral membrane protein
HPK20_14300	COG0783	Belongs to the Dps family
HPK20_14315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPK20_14320	COG0640	Transcriptional regulator
HPK20_14325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPK20_14330	COG1280	lysine exporter protein (LysE YggA)
HPK20_14335	COG2267	carboxylic ester hydrolase activity
HPK20_14340	COG0561	phosphatase activity
HPK20_14360	COG3287	FIST C domain
HPK20_14360	COG2199	diguanylate cyclase activity
HPK20_14360	COG2200	EAL domain
HPK20_14365	COG1011	Hydrolase
HPK20_14370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPK20_14380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPK20_14385	COG0019	diaminopimelate decarboxylase activity
HPK20_14395	COG1965	Belongs to the frataxin family
HPK20_14400	COG3072	Adenylate cyclase
HPK20_14415	COG2959	enzyme of heme biosynthesis
HPK20_14420	COG3071	HemY protein
HPK20_14425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPK20_14455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK20_14455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPK20_14470	COG0084	hydrolase, TatD family'
HPK20_14475	COG0805	protein transport
HPK20_14480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPK20_14490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPK20_14495	COG3165	ubiquinone biosynthetic process from chorismate
HPK20_14500	COG2226	methyltransferase
HPK20_14505	COG1322	Protein conserved in bacteria
HPK20_14530	COG2160	L-arabinose isomerase activity
HPK20_14535	COG0235	Class ii aldolase
HPK20_14540	COG1069	ribulokinase activity
HPK20_14545	COG1879	ABC-type sugar transport system periplasmic component
HPK20_14550	COG1129	ABC transporter
HPK20_14555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPK20_14560	COG2081	HI0933 family
HPK20_14570	COG1528	Iron-storage protein
HPK20_14575	COG0589	response to stress
HPK20_14580	COG0697	spore germination
HPK20_14595	COG5001	Diguanylate cyclase
HPK20_14595	COG5002	protein histidine kinase activity
HPK20_14600	COG1522	sequence-specific DNA binding
HPK20_14620	COG0006	proline dipeptidase activity
HPK20_14620	COG0006	proline dipeptidase activity
HPK20_14650	COG0517	IMP dehydrogenase activity
HPK20_14650	COG4175	Glycine betaine
HPK20_14665	COG2104	thiamine diphosphate biosynthetic process
HPK20_14665	COG2022	thiamine diphosphate biosynthetic process
HPK20_14670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK20_14675	COG0352	thiamine-phosphate diphosphorylase activity
HPK20_14680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPK20_14685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPK20_14690	COG2132	Multicopper oxidase
HPK20_14745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK20_14750	COG1739	Uncharacterized protein family UPF0029
HPK20_14760	COG0183	Belongs to the thiolase family
HPK20_14765	COG0583	DNA-binding transcription factor activity
HPK20_14770	COG2814	Major facilitator Superfamily
HPK20_14775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_14780	COG0765	amino acid transport
HPK20_14790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPK20_14795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPK20_14800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPK20_14805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPK20_14810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPK20_14815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPK20_14830	COG3312	ion transport
HPK20_14835	COG1475	DNA binding
HPK20_14840	COG1192	Involved in chromosome partitioning
HPK20_14845	COG0357	Ribosomal RNA small subunit methyltransferase G
HPK20_14850	COG0445	tRNA wobble uridine modification
HPK20_14855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPK20_14860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPK20_14865	COG0706	membrane insertase activity
HPK20_14880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPK20_14885	COG1126	abc transporter atp-binding protein
HPK20_14905	COG2433	Pfam Transposase IS66
HPK20_15000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK20_15015	COG2017	converts alpha-aldose to the beta-anomer
HPK20_15020	COG1609	Transcriptional regulator
HPK20_15045	COG2186	Transcriptional regulator
HPK20_15050	COG2731	YhcH YjgK YiaL family protein
HPK20_15065	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPK20_15070	COG1063	alcohol dehydrogenase
HPK20_15075	COG0246	Mannitol dehydrogenase
HPK20_15085	COG0800	Aldolase
HPK20_15090	COG4948	Mandelate Racemase Muconate Lactonizing
HPK20_15120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_15130	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK20_15150	COG0148	phosphopyruvate hydratase activity
HPK20_15180	COG0395	ABC-type sugar transport system, permease component
HPK20_15185	COG1175	transmembrane transport
HPK20_15200	COG2186	Transcriptional regulator
HPK20_15205	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_15220	COG2814	Major facilitator Superfamily
HPK20_15225	COG3547	Transposase (IS116 IS110 IS902 family)
HPK20_15240	COG3250	beta-galactosidase activity
HPK20_15250	COG4580	involved in the transport of maltose and maltodextrins
HPK20_15270	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPK20_15280	COG1609	Transcriptional regulator
HPK20_15290	COG1929	Belongs to the glycerate kinase type-1 family
HPK20_15295	COG0383	alpha-mannosidase activity
HPK20_15300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_15300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_15300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_15305	COG2188	Transcriptional regulator
HPK20_15325	COG0371	Dehydrogenase
HPK20_15500	COG4974	Belongs to the 'phage' integrase family
HPK20_15515	COG3132	Protein of unknown function, DUF480
HPK20_15520	COG2827	Endonuclease containing a URI domain
HPK20_15530	COG1879	ABC-type sugar transport system periplasmic component
HPK20_15535	COG0784	Response regulator, receiver
HPK20_15535	COG5002	protein histidine kinase activity
HPK20_15555	COG1492	cobalamin metabolic process
HPK20_15560	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPK20_15565	COG4149	molybdate abc transporter
HPK20_15570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPK20_15590	COG1289	transmembrane transporter activity
HPK20_15730	COG0210	DNA helicase
HPK20_15735	COG1335	isochorismatase
HPK20_15740	COG1803	Methylglyoxal synthase
HPK20_15745	COG1879	ABC-type sugar transport system periplasmic component
HPK20_15750	COG0784	Response regulator, receiver
HPK20_15750	COG2198	Histidine kinase
HPK20_15750	COG2205	protein histidine kinase activity
HPK20_15755	COG0469	pyruvate kinase activity
HPK20_15760	COG2271	Major facilitator Superfamily
HPK20_15785	COG1979	alcohol dehydrogenase
HPK20_15790	COG2207	Transcriptional regulator
HPK20_15805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPK20_15810	COG3706	GGDEF domain
HPK20_15830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_15835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPK20_15845	COG0183	Belongs to the thiolase family
HPK20_15885	COG0243	molybdopterin cofactor binding
HPK20_15900	COG3850	Histidine kinase
HPK20_15905	COG2197	response regulator
HPK20_15910	COG3069	C4-dicarboxylate transmembrane transporter activity
HPK20_15925	COG2814	Major facilitator Superfamily
HPK20_15935	COG0840	transmembrane signaling receptor activity
HPK20_15940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_15945	COG0545	Peptidyl-prolyl cis-trans isomerase
HPK20_15960	COG0840	transmembrane signaling receptor activity
HPK20_15965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPK20_15980	COG2897	thiosulfate sulfurtransferase activity
HPK20_15985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPK20_15995	COG0302	gtp cyclohydrolase
HPK20_16000	COG0531	amino acid
HPK20_16010	COG4303	Ethanolamine ammonia lyase large subunit
HPK20_16015	COG2207	Transcriptional regulator
HPK20_16020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_16020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPK20_16025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPK20_16030	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPK20_16045	COG1011	Hydrolase
HPK20_16050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPK20_16070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPK20_16080	COG3842	ATPase activity
HPK20_16100	COG2866	Carboxypeptidase
HPK20_16125	COG4166	transmembrane transport
HPK20_16130	COG4174	ABC transporter (Permease)
HPK20_16135	COG4239	(ABC) transporter, permease
HPK20_16140	COG4172	Belongs to the ABC transporter superfamily
HPK20_16145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPK20_16175	COG3706	GGDEF domain
HPK20_16190	COG2501	S4 domain
HPK20_16255	COG1979	alcohol dehydrogenase
HPK20_16260	COG2207	Transcriptional regulator
HPK20_16280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPK20_16290	COG0488	(ABC) transporter
HPK20_16300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPK20_16310	COG2814	Major facilitator Superfamily
HPK20_16330	COG3710	Transcriptional regulator
HPK20_16360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_16375	COG2233	PERMEase
HPK20_16395	COG1953	Uracil, thiamine, allantoin
HPK20_16405	COG0765	amino acid transport
HPK20_16410	COG0765	amino acid transport
HPK20_16440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPK20_16465	COG0402	S-adenosylhomocysteine deaminase activity
HPK20_16470	COG2351	hydroxyisourate hydrolase activity
HPK20_16510	COG1129	ABC transporter
HPK20_16515	COG1309	transcriptional regulator
HPK20_16525	COG3706	GGDEF domain
HPK20_16550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPK20_16555	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPK20_16565	COG0745	RESPONSE REGULATOR receiver
HPK20_16580	COG3140	Belongs to the UPF0181 family
HPK20_16645	COG0023	Translation Initiation Factor
HPK20_16670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPK20_16670	COG1042	CoA-binding domain protein
HPK20_16670	COG0045	succinate-CoA ligase (ADP-forming) activity
HPK20_16675	COG0583	DNA-binding transcription factor activity
HPK20_16680	COG1629	transport
HPK20_16680	COG4771	TonB-dependent receptor
HPK20_16700	COG2050	protein possibly involved in aromatic compounds catabolism
HPK20_16705	COG0501	Belongs to the peptidase M48B family
HPK20_16710	COG2824	Alkylphosphonate utilization operon protein PhnA
HPK20_16720	COG0861	Integral membrane protein TerC family
HPK20_16725	COG0737	Belongs to the 5'-nucleotidase family
HPK20_16730	COG3593	DNA synthesis involved in DNA repair
HPK20_16740	COG0583	DNA-binding transcription factor activity
HPK20_16745	COG2116	formate transmembrane transporter activity
HPK20_16750	COG2353	YceI-like domain
HPK20_16755	COG3038	cytochrome b561
HPK20_16780	COG5001	Diguanylate cyclase
HPK20_16790	COG0243	molybdopterin cofactor binding
HPK20_16795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK20_16805	COG5002	protein histidine kinase activity
HPK20_16805	COG0784	Response regulator, receiver
HPK20_16805	COG2205	protein histidine kinase activity
HPK20_16810	COG3437	response regulator, receiver
HPK20_16820	COG2207	Transcriptional regulator
HPK20_16825	COG0582	viral genome integration into host DNA
HPK20_16840	COG2203	Gaf domain
HPK20_16840	COG3706	GGDEF domain
HPK20_16840	COG4251	negative regulation of phosphorylation
HPK20_16840	COG5001	Diguanylate cyclase
HPK20_16875	COG2181	nitrate reductase activity
HPK20_16880	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPK20_16885	COG1140	nitrate reductase beta subunit
HPK20_16890	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPK20_16895	COG2223	nitrite transmembrane transporter activity
HPK20_16900	COG3850	Histidine kinase
HPK20_16905	COG2197	response regulator
HPK20_16910	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPK20_16915	COG2239	Acts as a magnesium transporter
HPK20_16920	COG0840	transmembrane signaling receptor activity
HPK20_16920	COG3290	protein histidine kinase activity
HPK20_16970	COG1518	maintenance of DNA repeat elements
HPK20_16995	COG2003	Belongs to the UPF0758 family
HPK20_17025	COG1160	GTP binding
HPK20_17040	COG0328	RNA-DNA hybrid ribonuclease activity
HPK20_17085	COG3501	Rhs element vgr protein
HPK20_17105	COG0523	cobalamin synthesis protein
HPK20_17120	COG0156	8-amino-7-oxononanoate synthase activity
HPK20_17125	COG2205	protein histidine kinase activity
HPK20_17125	COG0784	Response regulator, receiver
HPK20_17130	COG0419	ATPase involved in DNA repair
HPK20_17140	COG1609	Transcriptional regulator
HPK20_17145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_17145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_17150	COG1105	Belongs to the carbohydrate kinase PfkB family
HPK20_17155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_17155	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPK20_17155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_17160	COG4067	protein conserved in archaea
HPK20_17160	COG0189	ligase activity
HPK20_17170	COG0602	queuosine metabolic process
HPK20_17175	COG1328	CTP reductase activity
HPK20_17235	COG1280	lysine exporter protein (LysE YggA)
HPK20_17240	COG0745	RESPONSE REGULATOR receiver
HPK20_17250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPK20_17260	COG0583	DNA-binding transcription factor activity
HPK20_17275	COG1309	transcriptional regulator
HPK20_17280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPK20_17310	COG1335	isochorismatase
HPK20_17315	COG4977	sequence-specific DNA binding
HPK20_17320	COG0456	acetyltransferase
HPK20_17330	COG1280	lysine exporter protein (LysE YggA)
HPK20_17335	COG0494	nUDIX hydrolase
HPK20_17345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPK20_17375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_17395	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_17405	COG0454	-acetyltransferase
HPK20_17465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPK20_17470	COG0789	Transcriptional regulator
HPK20_17530	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_17540	COG4628	conserved protein (DUF2132)
HPK20_17560	COG0672	)-iron permease
HPK20_17580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPK20_17585	COG0513	Belongs to the DEAD box helicase family
HPK20_17600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK20_17610	COG0583	DNA-binding transcription factor activity
HPK20_17625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_17630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_17640	COG2207	Transcriptional regulator
HPK20_17645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_17645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_17645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_17655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_17680	COG1538	Outer membrane efflux protein
HPK20_17690	COG1132	(ABC) transporter
HPK20_17705	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPK20_17715	COG1349	DNA-binding transcription factor activity
HPK20_17720	COG0110	maltose O-acetyltransferase activity
HPK20_17725	COG3706	GGDEF domain
HPK20_17735	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPK20_17740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK20_17760	COG0747	negative chemotaxis
HPK20_17765	COG4172	Belongs to the ABC transporter superfamily
HPK20_17775	COG3437	response regulator, receiver
HPK20_17780	COG0784	Response regulator, receiver
HPK20_17780	COG2198	Histidine kinase
HPK20_17780	COG2205	protein histidine kinase activity
HPK20_17790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPK20_17815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_17830	COG2423	ornithine cyclodeaminase activity
HPK20_17840	COG4145	pantothenate transmembrane transporter activity
HPK20_17845	COG0583	DNA-binding transcription factor activity
HPK20_17850	COG0435	Glutathione S-transferase
HPK20_17855	COG0400	carboxylic ester hydrolase activity
HPK20_17860	COG1280	lysine exporter protein (LysE YggA)
HPK20_17875	COG1473	amidohydrolase
HPK20_17895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_17900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPK20_17905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPK20_17915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPK20_17930	COG2721	sulfolactate sulfo-lyase activity
HPK20_17985	COG0625	glutathione transferase activity
HPK20_17995	COG1472	Belongs to the glycosyl hydrolase 3 family
HPK20_18005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPK20_18015	COG0573	inorganic phosphate transmembrane transporter activity
HPK20_18020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK20_18040	COG1464	Belongs to the NlpA lipoprotein family
HPK20_18045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPK20_18045	COG0512	Glutamine amidotransferase of anthranilate synthase
HPK20_18065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPK20_18080	COG0653	protein targeting
HPK20_18100	COG2814	Major facilitator Superfamily
HPK20_18110	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_18120	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_18130	COG1024	Enoyl-CoA hydratase
HPK20_18135	COG1024	Enoyl-CoA hydratase
HPK20_18140	COG1960	acyl-CoA dehydrogenase activity
HPK20_18150	COG0183	Belongs to the thiolase family
HPK20_18160	COG1960	acyl-CoA dehydrogenase activity
HPK20_18165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPK20_18170	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPK20_18185	COG0450	alkyl hydroperoxide reductase
HPK20_18190	COG3634	alkyl hydroperoxide reductase activity
HPK20_18220	COG2207	Transcriptional regulator
HPK20_18220	COG1609	Transcriptional regulator
HPK20_18225	COG1454	alcohol dehydrogenase
HPK20_18230	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_18270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPK20_18285	COG2207	Transcriptional regulator
HPK20_18285	COG1609	Transcriptional regulator
HPK20_18290	COG4604	ABC transporter, ATP-binding protein
HPK20_18295	COG4605	iron ion homeostasis
HPK20_18300	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_18325	COG5380	lipid catabolic process
HPK20_18330	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPK20_18340	COG1522	sequence-specific DNA binding
HPK20_18360	COG2814	Major facilitator Superfamily
HPK20_18370	COG0840	transmembrane signaling receptor activity
HPK20_18385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPK20_18390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPK20_18395	COG3279	Response regulator of the LytR AlgR family
HPK20_18400	COG3275	phosphorelay sensor kinase activity
HPK20_18405	COG4989	oxidoreductase activity
HPK20_18420	COG0366	Alpha amylase catalytic
HPK20_18425	COG3227	Zinc metalloprotease (Elastase)
HPK20_18430	COG3047	cAMP biosynthetic process
HPK20_18435	COG0071	Belongs to the small heat shock protein (HSP20) family
HPK20_18450	COG0251	oxidation-reduction process
HPK20_18475	COG1132	(ABC) transporter
HPK20_18480	COG1132	(ABC) transporter
HPK20_18490	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HPK20_18495	COG2246	polysaccharide biosynthetic process
HPK20_18510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPK20_18520	COG0242	peptide deformylase activity
HPK20_18530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_18535	COG2084	Dehydrogenase
HPK20_18545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPK20_18550	COG0583	DNA-binding transcription factor activity
HPK20_18595	COG1063	alcohol dehydrogenase
HPK20_18600	COG0156	8-amino-7-oxononanoate synthase activity
HPK20_18605	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_18610	COG3284	Transcriptional regulator
HPK20_18620	COG0346	lactoylglutathione lyase activity
HPK20_18640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPK20_18650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_18655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPK20_18660	COG0363	glucosamine-6-phosphate deaminase activity
HPK20_18665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPK20_18680	COG0583	DNA-binding transcription factor activity
HPK20_18695	COG0646	methionine synthase
HPK20_18695	COG1410	methionine synthase
HPK20_18700	COG0531	amino acid
HPK20_18715	COG1473	amidohydrolase
HPK20_18720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_18725	COG1929	Belongs to the glycerate kinase type-1 family
HPK20_18730	COG2610	gluconate transmembrane transporter activity
HPK20_18735	COG3835	regulator
HPK20_18740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK20_18745	COG4533	DNA binding
HPK20_18760	COG0840	transmembrane signaling receptor activity
HPK20_18820	COG4964	Belongs to the GSP D family
HPK20_18860	COG0798	PFAM Bile acid sodium symporter
HPK20_18885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPK20_18890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPK20_18890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPK20_18900	COG0745	RESPONSE REGULATOR receiver
HPK20_18925	COG1278	Cold shock
HPK20_18930	COG4681	YaeQ
HPK20_18935	COG3706	GGDEF domain
HPK20_18940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPK20_18940	COG1017	nitric oxide dioxygenase activity
HPK20_18945	COG3604	Transcriptional regulator
HPK20_18955	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPK20_18960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPK20_18970	COG0366	Alpha amylase catalytic
HPK20_18990	COG0714	Associated with various cellular activities
HPK20_19010	COG2304	oxidoreductase activity
HPK20_19035	COG5002	protein histidine kinase activity
HPK20_19035	COG2205	protein histidine kinase activity
HPK20_19035	COG0784	Response regulator, receiver
HPK20_19050	COG3724	N-succinylarginine dihydrolase activity
HPK20_19055	COG1012	belongs to the aldehyde dehydrogenase family
HPK20_19080	COG4948	Mandelate Racemase Muconate Lactonizing
HPK20_19105	COG0583	DNA-binding transcription factor activity
HPK20_19130	COG3171	Protein conserved in bacteria
HPK20_19135	COG0589	response to stress
HPK20_19145	COG3530	Putative quorum-sensing-regulated virulence factor
HPK20_19155	COG0579	oxidoreductase
HPK20_19170	COG2204	response regulator
HPK20_19180	COG1929	Belongs to the glycerate kinase type-1 family
HPK20_19185	COG0383	alpha-mannosidase activity
HPK20_19190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_19190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_19190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPK20_19195	COG2188	Transcriptional regulator
HPK20_19220	COG5001	Diguanylate cyclase
HPK20_19220	COG3300	MHYT domain
HPK20_19225	COG2271	Major facilitator Superfamily
HPK20_19230	COG0584	glycerophosphoryl diester phosphodiesterase
HPK20_19235	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPK20_19240	COG0583	DNA-binding transcription factor activity
HPK20_19250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_19255	COG1879	ABC-type sugar transport system periplasmic component
HPK20_19260	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPK20_19265	COG1129	ABC transporter
HPK20_19270	COG1869	D-ribose catabolic process
HPK20_19385	COG1280	lysine exporter protein (LysE YggA)
HPK20_19390	COG1846	Transcriptional regulator
HPK20_19405	COG0564	pseudouridine synthase activity
HPK20_19410	COG1309	transcriptional regulator
HPK20_19415	COG2130	NADP-dependent
HPK20_19430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_19450	COG1177	transmembrane transport
HPK20_19460	COG3842	ATPase activity
HPK20_19470	COG2200	EAL domain
HPK20_19475	COG0656	L-ascorbic acid biosynthetic process
HPK20_19480	COG1902	pentaerythritol trinitrate reductase activity
HPK20_19485	COG0583	DNA-binding transcription factor activity
HPK20_19490	COG2814	Major facilitator Superfamily
HPK20_19510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPK20_19525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPK20_19535	COG4702	Belongs to the UPF0303 family
HPK20_19540	COG0673	inositol 2-dehydrogenase activity
HPK20_19545	COG1349	DNA-binding transcription factor activity
HPK20_19550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPK20_19570	COG3240	lipase activity
HPK20_19575	COG1028	Short-chain dehydrogenase reductase Sdr
HPK20_19590	COG1120	ATPase activity
HPK20_19595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_19600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_19605	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPK20_19610	COG4774	siderophore transport
HPK20_19635	COG0840	transmembrane signaling receptor activity
HPK20_19640	COG3384	dioxygenase
HPK20_19645	COG0583	DNA-binding transcription factor activity
HPK20_19655	COG1342	Belongs to the UPF0251 family
HPK20_19660	COG0778	Nitroreductase
HPK20_19665	COG0583	DNA-binding transcription factor activity
HPK20_19675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_19680	COG0697	spore germination
HPK20_19695	COG2814	Major facilitator Superfamily
HPK20_19700	COG0583	DNA-binding transcription factor activity
HPK20_19705	COG5001	Diguanylate cyclase
HPK20_19705	COG3300	MHYT domain
HPK20_19710	COG0739	heme binding
HPK20_19725	COG0659	secondary active sulfate transmembrane transporter activity
HPK20_19740	COG2199	diguanylate cyclase activity
HPK20_19745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPK20_19750	COG0581	inorganic phosphate transmembrane transporter activity
HPK20_19755	COG0573	inorganic phosphate transmembrane transporter activity
HPK20_19760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPK20_19765	COG0840	transmembrane signaling receptor activity
HPK20_19770	COG0513	Belongs to the DEAD box helicase family
HPK20_19780	COG1376	ErfK ybiS ycfS ynhG family protein
HPK20_19780	COG1388	LysM domain
HPK20_19785	COG0415	Belongs to the DNA photolyase family
HPK20_19795	COG3272	Protein of unknown function (DUF1722)
HPK20_19800	COG0813	purine-nucleoside phosphorylase activity
HPK20_19815	COG3706	GGDEF domain
HPK20_19825	COG1566	PFAM secretion protein HlyD family protein
HPK20_19860	COG0786	glutamate:sodium symporter activity
HPK20_19875	COG1999	signal sequence binding
HPK20_19885	COG1162	GTPase activity
HPK20_19890	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPK20_19905	COG4580	involved in the transport of maltose and maltodextrins
HPK20_19925	COG1132	(ABC) transporter
HPK20_19935	COG0671	phosphoesterase, PA-phosphatase related
HPK20_19945	COG3383	formate dehydrogenase (NAD+) activity
HPK20_19960	COG0840	transmembrane signaling receptor activity
HPK20_19970	COG1131	(ABC) transporter
HPK20_19975	COG2188	Transcriptional regulator
HPK20_19985	COG3033	Beta-eliminating lyase
HPK20_19990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPK20_19995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_20005	COG0471	metal ion transport
HPK20_20050	COG3501	Rhs element vgr protein
HPK20_20060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPK20_20065	COG1640	4-alpha-glucanotransferase
HPK20_20070	COG0058	SHG alpha-glucan phosphorylase activity
HPK20_20075	COG2909	trisaccharide binding
HPK20_20090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPK20_20095	COG1845	cytochrome c oxidase, subunit III
HPK20_20100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK20_20105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPK20_20120	COG2084	Dehydrogenase
HPK20_20135	COG0217	transcriptional regulatory protein
HPK20_20170	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPK20_20175	COG1444	tRNA N-acetyltransferase activity
HPK20_20190	COG0643	Histidine kinase
HPK20_20190	COG2198	Histidine kinase
HPK20_20200	COG0835	chemotaxis
HPK20_20205	COG0840	transmembrane signaling receptor activity
HPK20_20210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPK20_20220	COG2201	protein-glutamate methylesterase activity
HPK20_20235	COG0745	RESPONSE REGULATOR receiver
HPK20_20275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPK20_20310	COG0840	transmembrane signaling receptor activity
HPK20_20330	COG0513	Belongs to the DEAD box helicase family
HPK20_20340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPK20_20345	COG4597	amino acid ABC transporter
HPK20_20350	COG0765	amino acid transport
HPK20_20355	COG1126	abc transporter atp-binding protein
HPK20_20365	COG0724	RNA recognition motif
HPK20_20370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPK20_20375	COG1522	sequence-specific DNA binding
HPK20_20380	COG2610	gluconate transmembrane transporter activity
HPK20_20385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPK20_20390	COG3622	Belongs to the hyi family
HPK20_20395	COG0235	Class ii aldolase
HPK20_20400	COG3395	kinase activity
HPK20_20405	COG2084	Dehydrogenase
HPK20_20410	COG1349	DNA-binding transcription factor activity
HPK20_20425	COG0583	DNA-binding transcription factor activity
HPK20_20430	COG2910	NAD(P)H-binding
HPK20_20445	COG1335	isochorismatase
HPK20_20450	COG1609	Transcriptional regulator
HPK20_20450	COG2207	Transcriptional regulator
HPK20_20465	COG2329	Antibiotic biosynthesis monooxygenase
HPK20_20470	COG3304	Inner membrane component domain
HPK20_20480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_20515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPK20_20520	COG0419	ATPase involved in DNA repair
HPK20_20545	COG4581	dead DEAH box helicase
HPK20_20565	COG2176	DNA-directed DNA polymerase activity
HPK20_20585	COG0443	Heat shock 70 kDa protein
HPK20_20590	COG0095	Lipoate-protein ligase
HPK20_20605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPK20_20610	COG1473	amidohydrolase
HPK20_20625	COG3722	fumarate hydratase activity
HPK20_20635	COG2213	PTS system mannitol-specific
HPK20_20635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPK20_20640	COG0739	heme binding
HPK20_20655	COG0363	glucosamine-6-phosphate deaminase activity
HPK20_20680	COG0402	S-adenosylhomocysteine deaminase activity
HPK20_20685	COG2259	Doxx family
HPK20_20690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPK20_20695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPK20_20705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPK20_20710	COG1301	dicarboxylic acid transport
HPK20_20725	COG1917	Cupin 2, conserved barrel domain protein
HPK20_20725	COG2169	Transcriptional regulator
HPK20_20760	COG1764	response to oxidative stress
HPK20_20765	COG1846	Transcriptional regulator
HPK20_20770	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPK20_20790	COG1280	lysine exporter protein (LysE YggA)
HPK20_20800	COG1902	pentaerythritol trinitrate reductase activity
HPK20_20805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPK20_20815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPK20_20850	COG0109	protoheme IX farnesyltransferase activity
HPK20_20865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPK20_20895	COG2169	Transcriptional regulator
HPK20_20915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_20920	COG0697	spore germination
HPK20_20925	COG0477	Major facilitator Superfamily
HPK20_20930	COG0625	glutathione transferase activity
HPK20_20940	COG1942	4-Oxalocrotonate Tautomerase
HPK20_20955	COG0583	DNA-binding transcription factor activity
HPK20_20975	COG3152	Membrane
HPK20_20995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPK20_21010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPK20_21025	COG1620	l-lactate permease
HPK20_21030	COG0583	DNA-binding transcription factor activity
HPK20_21035	COG4172	Belongs to the ABC transporter superfamily
HPK20_21045	COG1067	ATP-dependent peptidase activity
HPK20_21050	COG0840	transmembrane signaling receptor activity
HPK20_21055	COG2211	Major facilitator Superfamily
HPK20_21060	COG0668	transmembrane transport
HPK20_21065	COG0569	domain protein
HPK20_21070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPK20_21080	COG3123	guanosine phosphorylase activity
HPK20_21085	COG1741	Belongs to the pirin family
HPK20_21095	COG5001	Diguanylate cyclase
HPK20_21120	COG3706	GGDEF domain
HPK20_21140	COG3706	GGDEF domain
HPK20_21165	COG2354	Protein conserved in bacteria
HPK20_21170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPK20_21175	COG0418	dihydroorotase activity
HPK20_21180	COG0633	Ferredoxin
HPK20_21180	COG3217	Mosc domain protein beta barrel domain protein
HPK20_21210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPK20_21215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPK20_21225	COG0848	biopolymer transport protein
HPK20_21230	COG0811	peptide transport
HPK20_21235	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPK20_21240	COG3721	Heme iron utilization protein
HPK20_21245	COG0748	coenzyme F420 binding
HPK20_21255	COG0531	amino acid
HPK20_21260	COG1522	sequence-specific DNA binding
HPK20_21290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPK20_21295	COG2200	EAL domain
HPK20_21325	COG3300	MHYT domain
HPK20_21325	COG5001	Diguanylate cyclase
HPK20_21340	COG1765	OsmC-like protein
HPK20_21375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPK20_21405	COG0745	RESPONSE REGULATOR receiver
HPK20_21410	COG0642	Histidine kinase
HPK20_21420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPK20_21425	COG3186	Phenylalanine-4-hydroxylase
HPK20_21430	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPK20_21435	COG0534	Mate efflux family protein
HPK20_21445	COG0861	Integral membrane protein TerC family
HPK20_21455	COG0456	acetyltransferase
HPK20_21460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPK20_21465	COG0662	Cupin 2, conserved barrel domain protein
HPK20_21470	COG0527	aspartate kinase activity
HPK20_21475	COG0561	phosphatase activity
HPK20_21485	COG0583	DNA-binding transcription factor activity
HPK20_21495	COG3437	response regulator, receiver
HPK20_21495	COG0784	Response regulator, receiver
HPK20_21505	COG0113	porphobilinogen synthase activity
HPK20_21515	COG0459	protein refolding
HPK20_21520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPK20_21545	COG2113	Glycine betaine
HPK20_21550	COG4176	ABC-type proline glycine betaine transport system permease component
HPK20_21555	COG4175	Glycine betaine
HPK20_21565	COG1166	arginine decarboxylase activity
HPK20_21575	COG1522	sequence-specific DNA binding
HPK20_21590	COG0765	amino acid transport
HPK20_21600	COG1686	Belongs to the peptidase S11 family
HPK20_21615	COG1566	PFAM secretion protein HlyD family protein
HPK20_21660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPK20_21670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPK20_21685	COG1280	lysine exporter protein (LysE YggA)
HPK20_21705	COG0840	transmembrane signaling receptor activity
HPK20_21720	COG2985	domain, Protein
HPK20_21730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPK20_21750	COG1280	lysine exporter protein (LysE YggA)
HPK20_21795	COG3122	Protein conserved in bacteria
HPK20_21815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPK20_21815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPK20_21820	COG0509	glycine decarboxylation via glycine cleavage system
HPK20_21835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPK20_21845	COG3706	GGDEF domain
HPK20_21850	COG5001	Diguanylate cyclase
HPK20_21855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_21870	COG0546	phosphoglycolate phosphatase activity
HPK20_21890	COG0484	heat shock protein binding
HPK20_21900	COG5001	Diguanylate cyclase
HPK20_21900	COG1716	ATPase activity
HPK20_21905	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPK20_21915	COG4181	ATPase activity
HPK20_21920	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPK20_21930	COG1984	allophanate hydrolase subunit 2
HPK20_21940	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPK20_21945	COG5002	protein histidine kinase activity
HPK20_21945	COG5001	Diguanylate cyclase
HPK20_21945	COG3447	MASE1 domain protein
HPK20_21950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPK20_21955	COG0840	transmembrane signaling receptor activity
HPK20_21960	COG0814	amino acid
HPK20_21965	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPK20_21970	COG0513	Belongs to the DEAD box helicase family
HPK20_21975	COG1309	transcriptional regulator
HPK20_21985	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPK20_22000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPK20_22040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPK20_22050	COG0463	Glycosyl transferase, family 2
HPK20_22060	COG0583	DNA-binding transcription factor activity
HPK20_22065	COG0697	spore germination
HPK20_22070	COG1917	Cupin 2, conserved barrel domain protein
HPK20_22070	COG2207	Transcriptional regulator
HPK20_22095	COG0330	HflC and HflK could
HPK20_22105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPK20_22120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPK20_22125	COG0583	DNA-binding transcription factor activity
HPK20_22130	COG3781	membrane
HPK20_22140	COG1271	oxidase subunit
HPK20_22145	COG1294	oxidase, subunit
HPK20_22150	COG0800	Aldolase
HPK20_22155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPK20_22160	COG1904	glucuronate isomerase
HPK20_22165	COG0246	Mannitol dehydrogenase
HPK20_22180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPK20_22190	COG2186	Transcriptional regulator
HPK20_22210	COG1070	Carbohydrate kinase
HPK20_22220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPK20_22235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPK20_22265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPK20_22295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPK20_22305	COG2116	formate transmembrane transporter activity
HPK20_22310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPK20_22310	COG1648	precorrin-2 dehydrogenase activity
HPK20_22340	COG3118	belongs to the thioredoxin family
HPK20_22345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPK20_22360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPK20_22370	COG1596	polysaccharide export
HPK20_22395	COG0438	transferase activity, transferring glycosyl groups
HPK20_22400	COG0438	transferase activity, transferring glycosyl groups
HPK20_22400	COG0297	glycogen (starch) synthase activity
HPK20_22415	COG0247	lactate metabolic process
HPK20_22420	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPK20_22425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPK20_22430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPK20_22435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPK20_22490	COG4386	tail sheath protein
HPK20_22530	COG4695	Portal protein
HPK20_22580	COG0667	Aldo Keto reductase
HPK20_22585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPK20_22595	COG0583	DNA-binding transcription factor activity
HPK20_22600	COG1335	isochorismatase
HPK20_22620	COG1017	nitric oxide dioxygenase activity
HPK20_22620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPK20_22625	COG0625	glutathione transferase activity