locus-tag	class	description
AL475_00005	COG0243	molybdopterin cofactor binding
AL475_00010	COG0437	4 iron, 4 sulfur cluster binding
AL475_00025	COG0004	ammonium transporteR
AL475_00030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL475_00035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL475_00040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL475_00045	COG1177	transmembrane transport
AL475_00050	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL475_00055	COG3842	ATPase activity
AL475_00080	COG0589	response to stress
AL475_00085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL475_00100	COG2217	Heavy metal translocating P-type atpase
AL475_00110	COG2010	Cytochrome c
AL475_00125	COG3278	Belongs to the heme-copper respiratory oxidase family
AL475_00225	COG3120	sequence-specific DNA binding
AL475_00230	COG1067	ATP-dependent peptidase activity
AL475_00235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL475_00260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL475_00260	COG0116	Belongs to the methyltransferase superfamily
AL475_00270	COG0167	dihydroorotate dehydrogenase activity
AL475_00285	COG0308	aminopeptidase N
AL475_00310	COG1956	GAF domain-containing protein
AL475_00315	COG1132	(ABC) transporter
AL475_00320	COG2995	paraquat-inducible protein a
AL475_00325	COG3008	intermembrane lipid transfer
AL475_00330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL475_00330	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AL475_00335	COG2996	Protein conserved in bacteria
AL475_00350	COG0574	Belongs to the PEP-utilizing enzyme family
AL475_00350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL475_00355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_00375	COG1115	amino acid carrier protein
AL475_00400	COG3501	Rhs element vgr protein
AL475_00410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL475_00420	COG1643	Atp-dependent helicase
AL475_00425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL475_00435	COG3005	denitrification pathway
AL475_00460	COG3706	GGDEF domain
AL475_00475	COG0443	Heat shock 70 kDa protein
AL475_00480	COG3706	GGDEF domain
AL475_00490	COG3706	GGDEF domain
AL475_00505	COG2999	glutathione oxidoreductase activity
AL475_00525	COG3706	GGDEF domain
AL475_00525	COG0745	RESPONSE REGULATOR receiver
AL475_00535	COG0243	molybdopterin cofactor binding
AL475_00540	COG3005	denitrification pathway
AL475_00550	COG0602	queuosine metabolic process
AL475_00555	COG0561	phosphatase activity
AL475_00565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_00570	COG4597	amino acid ABC transporter
AL475_00575	COG0765	amino acid transport
AL475_00580	COG1126	abc transporter atp-binding protein
AL475_00585	COG0670	Belongs to the BI1 family
AL475_00590	COG2920	part of a sulfur-relay system
AL475_00595	COG1254	Belongs to the acylphosphatase family
AL475_00600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL475_00605	COG3391	amine dehydrogenase activity
AL475_00615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL475_00625	COG2010	Cytochrome c
AL475_00645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL475_00650	COG5002	protein histidine kinase activity
AL475_00655	COG0745	RESPONSE REGULATOR receiver
AL475_00670	COG0668	transmembrane transport
AL475_00705	COG1278	Cold shock
AL475_00750	COG0745	RESPONSE REGULATOR receiver
AL475_00750	COG3706	GGDEF domain
AL475_00765	COG0835	chemotaxis
AL475_00765	COG0784	Response regulator, receiver
AL475_00775	COG4565	transcriptional regulatory protein
AL475_00780	COG3290	protein histidine kinase activity
AL475_00795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_00815	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL475_00820	COG3063	Type IV pilus biogenesis stability protein PilW
AL475_00835	COG1451	nucleotide metabolic process
AL475_00845	COG0583	DNA-binding transcription factor activity
AL475_00895	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL475_00900	COG4139	cobalamin transport
AL475_00905	COG2988	succinylglutamate desuccinylase activity
AL475_00920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL475_00925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL475_00930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL475_00935	COG0702	epimerase
AL475_00950	COG2925	Exonuclease
AL475_00960	COG1346	cytolysis
AL475_00965	COG0295	cytidine deaminase activity
AL475_00970	COG5001	Diguanylate cyclase
AL475_00970	COG3300	MHYT domain
AL475_00990	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL475_01000	COG0500	methyltransferase
AL475_01010	COG0776	regulation of translation
AL475_01015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_01015	COG0072	phenylalanine-tRNA ligase activity
AL475_01020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL475_01035	COG0745	RESPONSE REGULATOR receiver
AL475_01035	COG3706	GGDEF domain
AL475_01040	COG2133	pyrroloquinoline quinone binding
AL475_01075	COG0322	excinuclease ABC activity
AL475_01080	COG2197	response regulator
AL475_01085	COG0417	DNA replication proofreading
AL475_01090	COG5001	Diguanylate cyclase
AL475_01100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL475_01120	COG1228	amidohydrolase
AL475_01125	COG0010	Belongs to the arginase family
AL475_01135	COG2986	histidine ammonia-lyase
AL475_01155	COG0277	FAD linked oxidase domain protein
AL475_01155	COG0247	lactate metabolic process
AL475_01170	COG2885	chlorophyll binding
AL475_01195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL475_01200	COG1012	belongs to the aldehyde dehydrogenase family
AL475_01205	COG2957	Belongs to the agmatine deiminase family
AL475_01215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL475_01220	COG1012	belongs to the aldehyde dehydrogenase family
AL475_01225	COG1396	sequence-specific DNA binding
AL475_01225	COG1917	Cupin 2, conserved barrel domain protein
AL475_01230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL475_01235	COG0174	glutamine synthetase
AL475_01240	COG1757	Na H antiporter
AL475_01255	COG0583	DNA-binding transcription factor activity
AL475_01270	COG1643	Atp-dependent helicase
AL475_01275	COG0281	malic enzyme
AL475_01310	COG0583	DNA-binding transcription factor activity
AL475_01325	COG0640	Transcriptional regulator
AL475_01350	COG2949	membrane
AL475_01360	COG1414	Transcriptional regulator
AL475_01365	COG1414	Transcriptional regulator
AL475_01375	COG1454	alcohol dehydrogenase
AL475_01380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL475_01400	COG0492	ferredoxin-NADP+ reductase activity
AL475_01405	COG4988	ABC transporter
AL475_01410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL475_01425	COG1187	pseudouridine synthase activity
AL475_01430	COG0009	L-threonylcarbamoyladenylate synthase
AL475_01435	COG0613	PHP domain protein
AL475_01445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL475_01450	COG0512	Glutamine amidotransferase of anthranilate synthase
AL475_01455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL475_01460	COG0134	indole-3-glycerol-phosphate synthase activity
AL475_01460	COG0135	phosphoribosylanthranilate isomerase activity
AL475_01465	COG0133	tryptophan synthase activity
AL475_01475	COG1301	dicarboxylic acid transport
AL475_01490	COG1607	acyl-coa hydrolase
AL475_01495	COG2350	Protein conserved in bacteria
AL475_01505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL475_01510	COG0583	DNA-binding transcription factor activity
AL475_01525	COG0612	Peptidase, M16
AL475_01545	COG0625	glutathione transferase activity
AL475_01555	COG2200	EAL domain
AL475_01555	COG2771	luxR family
AL475_01560	COG0840	transmembrane signaling receptor activity
AL475_01575	COG1794	racemase activity, acting on amino acids and derivatives
AL475_01580	COG0346	lactoylglutathione lyase activity
AL475_01585	COG5002	protein histidine kinase activity
AL475_01590	COG0745	RESPONSE REGULATOR receiver
AL475_01610	COG0488	(ABC) transporter
AL475_01615	COG1032	radical SAM domain protein
AL475_01620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL475_01630	COG4191	Histidine kinase
AL475_01630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_01645	COG3070	regulator of competence-specific genes
AL475_01655	COG2431	L-lysine efflux transmembrane transporter activity
AL475_01665	COG0076	glutamate decarboxylase activity
AL475_01670	COG1737	Transcriptional regulator
AL475_01675	COG1012	belongs to the aldehyde dehydrogenase family
AL475_01675	COG1454	alcohol dehydrogenase
AL475_01680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL475_01690	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL475_01695	COG1960	acyl-CoA dehydrogenase activity
AL475_01715	COG1012	belongs to the aldehyde dehydrogenase family
AL475_01730	COG5002	protein histidine kinase activity
AL475_01730	COG0784	Response regulator, receiver
AL475_01740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL475_01745	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL475_01750	COG2885	chlorophyll binding
AL475_01770	COG0811	peptide transport
AL475_01775	COG0824	Thioesterase
AL475_01785	COG4890	Cyd operon protein YbgT
AL475_01790	COG1294	oxidase, subunit
AL475_01795	COG1271	oxidase subunit
AL475_01800	COG2255	four-way junction helicase activity
AL475_01805	COG0632	four-way junction helicase activity
AL475_01810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL475_01815	COG0215	cysteine-tRNA ligase activity
AL475_01820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL475_01825	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL475_01830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL475_01835	COG3012	SEC-C Motif Domain Protein
AL475_01845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL475_01850	COG1199	ATP-dependent helicase activity
AL475_01855	COG3923	Primosomal replication protein n
AL475_01870	COG0708	Exodeoxyribonuclease III
AL475_01875	COG4160	amino acid transport
AL475_01880	COG4215	(ABC) transporter
AL475_01900	COG1882	Formate acetyltransferase
AL475_01915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL475_01935	COG2766	serine protein kinase
AL475_01940	COG2718	Belongs to the UPF0229 family
AL475_01945	COG2719	SpoVR family
AL475_01950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL475_01965	COG1132	(ABC) transporter
AL475_01970	COG2333	competence protein COMEC
AL475_01970	COG0658	competence protein
AL475_01980	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL475_01985	COG1136	(ABC) transporter
AL475_01990	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL475_02000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL475_02015	COG1252	NADH dehydrogenase
AL475_02045	COG0537	adenosine 5'-monophosphoramidase activity
AL475_02060	COG2186	Transcriptional regulator
AL475_02065	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL475_02070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL475_02075	COG1674	ftsk spoiiie
AL475_02080	COG1522	sequence-specific DNA binding
AL475_02085	COG0686	Belongs to the AlaDH PNT family
AL475_02095	COG0583	DNA-binding transcription factor activity
AL475_02115	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL475_02120	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL475_02130	COG0539	negative regulation of cytoplasmic translation
AL475_02135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL475_02140	COG1555	photosystem II stabilization
AL475_02145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL475_02150	COG0776	regulation of translation
AL475_02155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL475_02160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL475_02170	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL475_02180	COG4191	Histidine kinase
AL475_02185	COG2204	response regulator
AL475_02190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL475_02195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL475_02200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL475_02220	COG0745	RESPONSE REGULATOR receiver
AL475_02225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL475_02230	COG1760	l-serine dehydratase
AL475_02240	COG3153	acetyltransferase
AL475_02240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL475_02250	COG1716	ATPase activity
AL475_02250	COG5001	Diguanylate cyclase
AL475_02260	COG4589	Belongs to the CDS family
AL475_02295	COG2197	response regulator
AL475_02300	COG3851	Histidine kinase
AL475_02305	COG2271	Major facilitator Superfamily
AL475_02310	COG1840	ABC-type Fe3 transport system, periplasmic component
AL475_02320	COG3842	ATPase activity
AL475_02410	COG3550	peptidyl-serine autophosphorylation
AL475_02430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_02435	COG0569	domain protein
AL475_02440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_02445	COG0745	RESPONSE REGULATOR receiver
AL475_02450	COG2205	protein histidine kinase activity
AL475_02455	COG0668	transmembrane transport
AL475_02460	COG1477	protein flavinylation
AL475_02470	COG1968	undecaprenyl-diphosphatase activity
AL475_02475	COG1742	UPF0060 membrane protein
AL475_02480	COG1280	lysine exporter protein (LysE YggA)
AL475_02490	COG1279	arginine transmembrane transporter activity
AL475_02505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL475_02510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL475_02520	COG2951	lytic endotransglycosylase activity
AL475_02525	COG3100	YcgL domain-containing protein
AL475_02540	COG2894	cell division
AL475_02545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL475_02555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL475_02560	COG0318	PFAM AMP-dependent synthetase and ligase
AL475_02580	COG1214	PFAM Peptidase M22, glycoprotease
AL475_02585	COG1199	ATP-dependent helicase activity
AL475_02595	COG0788	formyltetrahydrofolate deformylase activity
AL475_02600	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL475_02600	COG1902	pentaerythritol trinitrate reductase activity
AL475_02605	COG0616	signal peptide processing
AL475_02610	COG0252	asparaginase activity
AL475_02615	COG3139	Protein of unknown function (DUF1315)
AL475_02625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_02630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL475_02640	COG2226	methyltransferase
AL475_02670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL475_02675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL475_02680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL475_02690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL475_02695	COG2832	Protein of unknown function (DUF454)
AL475_02705	COG0745	RESPONSE REGULATOR receiver
AL475_02710	COG0583	DNA-binding transcription factor activity
AL475_02715	COG0778	Nitroreductase
AL475_02720	COG1024	Enoyl-CoA hydratase
AL475_02720	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL475_02725	COG0183	Belongs to the thiolase family
AL475_02740	COG2067	long-chain fatty acid transport protein
AL475_02745	COG2067	long-chain fatty acid transport protein
AL475_02750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL475_02765	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL475_02770	COG2982	Protein involved in outer membrane biogenesis
AL475_02775	COG0572	uridine kinase
AL475_02780	COG0489	protein tyrosine kinase activity
AL475_02785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_02785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_02795	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL475_02805	COG0517	IMP dehydrogenase activity
AL475_02805	COG0516	GMP reductase activity
AL475_02810	COG3706	GGDEF domain
AL475_02815	COG0314	molybdopterin synthase activity
AL475_02820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL475_02825	COG0315	cyclic pyranopterin monophosphate synthase activity
AL475_02830	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL475_02835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL475_02840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL475_02845	COG2198	Histidine kinase
AL475_02850	COG2204	response regulator
AL475_02865	COG4657	Part of a membrane complex involved in electron transport
AL475_02870	COG2878	Part of a membrane complex involved in electron transport
AL475_02880	COG4658	electron transport chain
AL475_02885	COG4659	FMN binding
AL475_02890	COG4660	Part of a membrane complex involved in electron transport
AL475_02895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL475_02900	COG0346	lactoylglutathione lyase activity
AL475_02915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL475_02920	COG2056	Na+-H+ antiporter family
AL475_02925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL475_02930	COG1286	toxin biosynthetic process
AL475_02935	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL475_02940	COG0285	dihydrofolate synthase activity
AL475_02950	COG0101	tRNA pseudouridine synthase activity
AL475_02960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL475_02965	COG1263	PTS System
AL475_02965	COG2190	(PTS) system
AL475_02965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_02970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL475_02975	COG1940	carbohydrate kinase activity
AL475_02975	COG1846	Transcriptional regulator
AL475_02980	COG4651	solute:proton antiporter activity
AL475_02980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL475_02985	COG0367	asparagine synthase
AL475_02995	COG3104	oligopeptide transport
AL475_03000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL475_03010	COG0326	Molecular chaperone. Has ATPase activity
AL475_03015	COG3710	Transcriptional regulator
AL475_03030	COG0622	Phosphoesterase
AL475_03055	COG1090	epimerase
AL475_03060	COG0300	oxidoreductase activity
AL475_03070	COG3118	belongs to the thioredoxin family
AL475_03075	COG0330	HflC and HflK could
AL475_03085	COG0789	Transcriptional regulator
AL475_03100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL475_03105	COG3115	cell septum assembly
AL475_03110	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL475_03115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL475_03125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_03135	COG2190	(PTS) system
AL475_03140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL475_03145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL475_03150	COG1702	phosphate starvation-inducible protein PhoH
AL475_03155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL475_03160	COG4535	Mg2 and Co2 transporter CorC
AL475_03165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL475_03170	COG2888	peptidyl-tyrosine sulfation
AL475_03180	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL475_03185	COG1466	dna polymerase III delta subunit
AL475_03190	COG0799	negative regulation of ribosome biogenesis
AL475_03195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL475_03200	COG0768	penicillin binding
AL475_03205	COG0772	Belongs to the SEDS family
AL475_03210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL475_03215	COG1686	Belongs to the peptidase S11 family
AL475_03220	COG2921	Belongs to the UPF0250 family
AL475_03225	COG0321	lipoyl(octanoyl) transferase activity
AL475_03230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL475_03240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL475_03250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_03255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_03295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL475_03300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL475_03305	COG2011	ABC-type metal ion transport system permease component
AL475_03310	COG1464	Belongs to the NlpA lipoprotein family
AL475_03315	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL475_03325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL475_03325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL475_03335	COG3706	GGDEF domain
AL475_03335	COG0745	RESPONSE REGULATOR receiver
AL475_03340	COG1611	Belongs to the LOG family
AL475_03345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL475_03355	COG2363	Small membrane protein
AL475_03365	COG0583	DNA-binding transcription factor activity
AL475_03370	COG0301	tRNA thio-modification
AL475_03370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL475_03380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL475_03390	COG0142	geranyltranstransferase activity
AL475_03395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL475_03400	COG0564	pseudouridine synthase activity
AL475_03405	COG3098	single-species biofilm formation
AL475_03430	COG1671	Belongs to the UPF0178 family
AL475_03435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_03440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL475_03450	COG1720	tRNA m6t6A37 methyltransferase activity
AL475_03455	COG0442	prolyl-tRNA aminoacylation
AL475_03480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL475_03485	COG0590	tRNA wobble adenosine to inosine editing
AL475_03490	COG0583	DNA-binding transcription factor activity
AL475_03495	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL475_03500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AL475_03505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_03540	COG0443	Heat shock 70 kDa protein
AL475_03550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL475_03555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL475_03560	COG0497	DNA recombination
AL475_03565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL475_03570	COG2914	Belongs to the UPF0125 (RnfH) family
AL475_03575	COG2867	negative regulation of translational initiation
AL475_03580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL475_03590	COG0582	viral genome integration into host DNA
AL475_03610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL475_03625	COG2003	Belongs to the UPF0758 family
AL475_03660	COG1479	Protein of unknown function DUF262
AL475_03695	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_03765	COG0583	DNA-binding transcription factor activity
AL475_03770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL475_03775	COG1115	amino acid carrier protein
AL475_03785	COG1473	amidohydrolase
AL475_03800	COG1584	GPR1 FUN34 yaaH family protein
AL475_03820	COG0210	DNA helicase
AL475_03880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL475_03885	COG0582	viral genome integration into host DNA
AL475_03890	COG0519	Catalyzes the synthesis of GMP from XMP
AL475_03890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL475_03895	COG0517	IMP dehydrogenase activity
AL475_03895	COG0516	GMP reductase activity
AL475_03900	COG1570	exodeoxyribonuclease VII activity
AL475_03915	COG1160	GTP binding
AL475_03920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL475_03925	COG2976	Protein conserved in bacteria
AL475_03930	COG0124	histidyl-tRNA synthetase
AL475_03935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL475_03955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL475_03960	COG2975	iron-sulfur cluster assembly
AL475_03965	COG0633	Ferredoxin
AL475_03970	COG0443	Heat shock 70 kDa protein
AL475_03985	COG0822	iron-sulfur transferase activity
AL475_03990	COG1104	cysteine desulfurase activity
AL475_03995	COG1959	2 iron, 2 sulfur cluster binding
AL475_04000	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL475_04005	COG0483	inositol monophosphate 1-phosphatase activity
AL475_04010	COG1335	isochorismatase
AL475_04015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_04020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_04025	COG1862	Preprotein translocase
AL475_04030	COG0343	queuine tRNA-ribosyltransferase activity
AL475_04035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL475_04040	COG0517	IMP dehydrogenase activity
AL475_04050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL475_04055	COG0583	DNA-binding transcription factor activity
AL475_04060	COG0450	alkyl hydroperoxide reductase
AL475_04075	COG0704	Plays a role in the regulation of phosphate uptake
AL475_04080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL475_04085	COG0581	inorganic phosphate transmembrane transporter activity
AL475_04090	COG0573	inorganic phosphate transmembrane transporter activity
AL475_04100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL475_04105	COG0248	Ppx GppA phosphatase
AL475_04115	COG5002	protein histidine kinase activity
AL475_04120	COG0745	RESPONSE REGULATOR receiver
AL475_04125	COG2974	May be involved in recombination
AL475_04135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL475_04140	COG0477	Major facilitator Superfamily
AL475_04150	COG1595	DNA-templated transcription, initiation
AL475_04160	COG3248	Nucleoside-binding outer membrane protein
AL475_04165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL475_04170	COG0693	protein deglycase activity
AL475_04175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL475_04185	COG2166	iron-sulfur cluster assembly
AL475_04190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL475_04195	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL475_04205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL475_04205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL475_04215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL475_04220	COG1074	ATP-dependent DNA helicase activity
AL475_04225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL475_04240	COG3141	response to X-ray
AL475_04245	COG2171	N-acyltransferase activity
AL475_04250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL475_04265	COG0189	ligase activity
AL475_04265	COG0569	domain protein
AL475_04280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL475_04285	COG2017	converts alpha-aldose to the beta-anomer
AL475_04295	COG2059	Chromate
AL475_04300	COG3437	response regulator, receiver
AL475_04300	COG0784	Response regulator, receiver
AL475_04350	COG4964	Belongs to the GSP D family
AL475_04390	COG0583	DNA-binding transcription factor activity
AL475_04400	COG0583	DNA-binding transcription factor activity
AL475_04405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL475_04410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL475_04420	COG0560	Phosphoserine phosphatase
AL475_04430	COG0813	purine-nucleoside phosphorylase activity
AL475_04435	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL475_04440	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL475_04445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL475_04455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL475_04480	COG0084	hydrolase, TatD family'
AL475_04490	COG1115	amino acid carrier protein
AL475_04505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL475_04520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL475_04525	COG0083	homoserine kinase activity
AL475_04545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_04560	COG0745	RESPONSE REGULATOR receiver
AL475_04570	COG2198	Histidine kinase
AL475_04570	COG0784	Response regulator, receiver
AL475_04570	COG5002	protein histidine kinase activity
AL475_04575	COG5001	Diguanylate cyclase
AL475_04575	COG4251	negative regulation of phosphorylation
AL475_04575	COG3706	GGDEF domain
AL475_04575	COG2203	Gaf domain
AL475_04580	COG1242	4 iron, 4 sulfur cluster binding
AL475_04585	COG0067	glutamate synthase
AL475_04585	COG0070	glutamate synthase
AL475_04585	COG0069	glutamate synthase activity
AL475_04595	COG0070	glutamate synthase
AL475_04595	COG0069	glutamate synthase activity
AL475_04595	COG0067	glutamate synthase
AL475_04600	COG0493	'glutamate synthase
AL475_04620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL475_04625	COG2860	membrane
AL475_04645	COG0583	DNA-binding transcription factor activity
AL475_04650	COG0730	response to heat
AL475_04655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL475_04660	COG0505	Belongs to the CarA family
AL475_04670	COG0494	nUDIX hydrolase
AL475_04675	COG0653	protein targeting
AL475_04685	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL475_04690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL475_04695	COG0849	cell division
AL475_04700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL475_04705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL475_04710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL475_04715	COG0772	Belongs to the SEDS family
AL475_04720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL475_04725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL475_04730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL475_04735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL475_04740	COG0768	penicillin binding
AL475_04745	COG3116	cell division
AL475_04750	COG0275	rRNA processing
AL475_04760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL475_04765	COG3107	peptidoglycan biosynthetic process
AL475_04770	COG0792	nuclease activity
AL475_04775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL475_04780	COG2823	Periplasmic or secreted lipoprotein
AL475_04785	COG2969	positive regulation of protein catabolic process
AL475_04790	COG0625	glutathione transferase activity
AL475_04795	COG2857	Cytochrome c1
AL475_04800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL475_04805	COG0723	plastoquinol--plastocyanin reductase activity
AL475_04810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL475_04815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL475_04825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL475_04830	COG3105	Protein conserved in bacteria
AL475_04835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL475_04840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL475_04845	COG0335	large ribosomal subunit rRNA binding
AL475_04855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL475_04865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL475_04870	COG4137	Cytochrome C assembly protein
AL475_04875	COG4536	flavin adenine dinucleotide binding
AL475_04880	COG1854	S-ribosylhomocysteine lyase activity
AL475_04895	COG0612	Peptidase, M16
AL475_04900	COG1238	metal cluster binding
AL475_04905	COG1063	alcohol dehydrogenase
AL475_04910	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL475_04915	COG0511	ligase activity, forming carbon-carbon bonds
AL475_04915	COG5016	pyruvate
AL475_04920	COG3630	sodium ion export across plasma membrane
AL475_04970	COG0527	aspartate kinase activity
AL475_04975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL475_04985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL475_04990	COG1546	Belongs to the CinA family
AL475_04995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL475_05000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL475_05005	COG1388	LysM domain
AL475_05005	COG4942	peptidase
AL475_05015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL475_05020	COG0585	pseudouridine synthase activity
AL475_05030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL475_05035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL475_05040	COG1968	undecaprenyl-diphosphatase activity
AL475_05045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL475_05050	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL475_05055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL475_05060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL475_05065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL475_05070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL475_05075	COG1610	YqeY-like protein
AL475_05085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL475_05095	COG0582	viral genome integration into host DNA
AL475_05115	COG2203	Gaf domain
AL475_05115	COG5001	Diguanylate cyclase
AL475_05115	COG3706	GGDEF domain
AL475_05115	COG4251	negative regulation of phosphorylation
AL475_05150	COG3706	GGDEF domain
AL475_05160	COG2003	Belongs to the UPF0758 family
AL475_05215	COG0668	transmembrane transport
AL475_05225	COG1968	undecaprenyl-diphosphatase activity
AL475_05255	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_05310	COG2239	Acts as a magnesium transporter
AL475_05330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_05335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL475_05340	COG1349	DNA-binding transcription factor activity
AL475_05345	COG0469	pyruvate kinase activity
AL475_05355	COG3706	GGDEF domain
AL475_05380	COG0668	transmembrane transport
AL475_05385	COG0191	fructose-bisphosphate aldolase activity
AL475_05390	COG0126	phosphoglycerate kinase activity
AL475_05395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL475_05400	COG4771	TonB-dependent receptor
AL475_05405	COG0583	DNA-binding transcription factor activity
AL475_05410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL475_05430	COG2356	endonuclease I
AL475_05435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL475_05440	COG0189	ligase activity
AL475_05445	COG1678	Uncharacterized ACR, COG1678
AL475_05450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL475_05465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL475_05470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL475_05475	COG0762	integral membrane protein
AL475_05480	COG1872	DUF167
AL475_05495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL475_05500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL475_05505	COG2066	Belongs to the glutaminase family
AL475_05510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL475_05515	COG1194	a g-specific adenine glycosylase
AL475_05520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL475_05525	COG0741	lytic transglycosylase activity
AL475_05580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL475_05585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL475_05590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL475_05605	COG2967	ApaG domain
AL475_05620	COG3610	response to peptide
AL475_05625	COG2966	Psort location CytoplasmicMembrane, score
AL475_05630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL475_05635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL475_05640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL475_05645	COG0142	geranyltranstransferase activity
AL475_05650	COG0531	amino acid
AL475_05655	COG0039	L-malate dehydrogenase activity
AL475_05675	COG0589	response to stress
AL475_05695	COG0312	modulator of DNA gyrase
AL475_05700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL475_05705	COG3164	Protein of unknown function
AL475_05710	COG1530	ribonuclease E activity
AL475_05715	COG0424	maF-like protein
AL475_05720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL475_05725	COG1792	Involved in formation and maintenance of cell shape
AL475_05730	COG1077	Cell shape determining protein MreB Mrl
AL475_05780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL475_05790	COG3409	Peptidoglycan-binding domain 1 protein
AL475_05790	COG3267	Type II secretory pathway component ExeA
AL475_05815	COG2199	diguanylate cyclase activity
AL475_05815	COG2200	EAL domain
AL475_05820	COG0629	single-stranded DNA binding
AL475_05835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL475_05845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL475_05850	COG0527	aspartate kinase activity
AL475_05855	COG1410	methionine synthase
AL475_05855	COG0646	methionine synthase
AL475_05935	COG0175	sulfate reduction
AL475_05965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL475_05970	COG0735	belongs to the Fur family
AL475_05980	COG0166	Belongs to the GPI family
AL475_05985	COG0432	Pfam Uncharacterised protein family UPF0047
AL475_05990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL475_05995	COG0305	Participates in initiation and elongation during chromosome replication
AL475_06005	COG0359	binds to the 23S rRNA
AL475_06015	COG2965	DNA replication, synthesis of RNA primer
AL475_06020	COG0360	Binds together with S18 to 16S ribosomal RNA
AL475_06030	COG2906	2 iron, 2 sulfur cluster binding
AL475_06040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL475_06045	COG0049	tRNA binding
AL475_06055	COG2168	tRNA wobble position uridine thiolation
AL475_06060	COG2923	Belongs to the DsrF TusC family
AL475_06070	COG2964	Protein conserved in bacteria
AL475_06075	COG0545	Peptidyl-prolyl cis-trans isomerase
AL475_06085	COG2900	Belongs to the SlyX family
AL475_06090	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL475_06095	COG0330	HflC and HflK could
AL475_06100	COG0330	HflC and HflK could
AL475_06105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL475_06110	COG1923	regulation of RNA biosynthetic process
AL475_06120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL475_06130	COG0802	atpase or kinase
AL475_06135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL475_06185	COG1162	GTPase activity
AL475_06190	COG0688	phosphatidylethanolamine metabolic process
AL475_06195	COG0471	metal ion transport
AL475_06195	COG0490	domain, Protein
AL475_06210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL475_06215	COG4942	peptidase
AL475_06235	COG2816	NAD+ diphosphatase activity
AL475_06240	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL475_06245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL475_06250	COG0085	RNA polymerase activity
AL475_06260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL475_06265	COG0081	regulation of translation
AL475_06270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL475_06275	COG0250	Participates in transcription elongation, termination and antitermination
AL475_06280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL475_06315	COG1072	(Pantothenic acid kinase))
AL475_06325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL475_06335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL475_06400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL475_06410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL475_06415	COG3118	belongs to the thioredoxin family
AL475_06420	COG0513	Belongs to the DEAD box helicase family
AL475_06425	COG0248	Ppx GppA phosphatase
AL475_06430	COG2198	Histidine kinase
AL475_06430	COG0784	Response regulator, receiver
AL475_06430	COG2205	protein histidine kinase activity
AL475_06435	COG2814	Major facilitator Superfamily
AL475_06450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL475_06455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL475_06460	COG0511	ligase activity, forming carbon-carbon bonds
AL475_06465	COG0439	Biotin carboxylase
AL475_06470	COG2264	protein methyltransferase activity
AL475_06475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL475_06480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL475_06485	COG0840	transmembrane signaling receptor activity
AL475_06490	COG0789	Transcriptional regulator
AL475_06500	COG0138	bifunctional purine biosynthesis protein purh
AL475_06505	COG0151	Belongs to the GarS family
AL475_06515	COG0776	regulation of translation
AL475_06520	COG1253	flavin adenine dinucleotide binding
AL475_06525	COG0668	transmembrane transport
AL475_06530	COG3068	Protein conserved in bacteria
AL475_06535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_06540	COG1573	uracil-dna glycosylase
AL475_06545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL475_06555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL475_06615	COG1086	Polysaccharide biosynthesis protein
AL475_06620	COG0438	transferase activity, transferring glycosyl groups
AL475_06625	COG2264	protein methyltransferase activity
AL475_06650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL475_06660	COG1560	Kdo2-lipid A biosynthetic process
AL475_06665	COG3307	-O-antigen
AL475_06670	COG0859	PFAM glycosyl transferase family 9
AL475_06675	COG0859	PFAM glycosyl transferase family 9
AL475_06680	COG1519	Transferase
AL475_06685	COG0438	transferase activity, transferring glycosyl groups
AL475_06695	COG0859	PFAM glycosyl transferase family 9
AL475_06700	COG0463	Glycosyl transferase, family 2
AL475_06705	COG0438	transferase activity, transferring glycosyl groups
AL475_06710	COG0438	transferase activity, transferring glycosyl groups
AL475_06715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL475_06730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL475_06740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL475_06765	COG1309	transcriptional regulator
AL475_06770	COG1560	Kdo2-lipid A biosynthetic process
AL475_06775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL475_06780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL475_06785	COG1561	YicC-like family, N-terminal region
AL475_06805	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL475_06810	COG1120	ATPase activity
AL475_06815	COG1132	(ABC) transporter
AL475_06830	COG0514	ATP-dependent DNA helicase (RecQ)
AL475_06835	COG2962	Rard protein
AL475_06845	COG1280	lysine exporter protein (LysE YggA)
AL475_06850	COG0405	Gamma-glutamyltransferase
AL475_06855	COG0210	DNA helicase
AL475_06890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL475_06895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL475_06910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_06915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_06925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_06935	COG0747	negative chemotaxis
AL475_06940	COG4172	Belongs to the ABC transporter superfamily
AL475_06975	COG0210	DNA helicase
AL475_06985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_06990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_06995	COG2960	long-chain fatty acid transporting porin activity
AL475_07005	COG0583	DNA-binding transcription factor activity
AL475_07055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL475_07065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL475_07070	COG0408	coproporphyrinogen oxidase activity
AL475_07085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL475_07090	COG0551	DNA topoisomerase type I activity
AL475_07095	COG2922	Belongs to the Smg family
AL475_07100	COG0758	DNA mediated transformation
AL475_07105	COG1652	LysM domain
AL475_07110	COG0242	peptide deformylase activity
AL475_07120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL475_07120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL475_07125	COG0569	domain protein
AL475_07130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_07140	COG1272	protein, Hemolysin III
AL475_07145	COG4326	sporulation control protein
AL475_07155	COG3084	Protein conserved in bacteria
AL475_07165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL475_07170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL475_07175	COG0204	Acyl-transferase
AL475_07180	COG0606	chelatase, subunit chli
AL475_07190	COG3978	acetolactate synthase activity
AL475_07195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL475_07210	COG0604	alcohol dehydrogenase
AL475_07235	COG2119	membrane
AL475_07240	COG0752	glycyl-tRNA synthetase alpha subunit
AL475_07245	COG0751	glycine-tRNA ligase activity
AL475_07250	COG3977	Valine--pyruvate aminotransferase
AL475_07255	COG0071	Belongs to the small heat shock protein (HSP20) family
AL475_07260	COG0187	DNA topoisomerase II activity
AL475_07265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL475_07270	COG0592	DNA-directed DNA polymerase activity
AL475_07275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL475_07290	COG1126	abc transporter atp-binding protein
AL475_07295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL475_07305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL475_07310	COG0706	membrane insertase activity
AL475_07320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL475_07325	COG0445	tRNA wobble uridine modification
AL475_07330	COG0357	Ribosomal RNA small subunit methyltransferase G
AL475_07335	COG1192	Involved in chromosome partitioning
AL475_07340	COG1475	DNA binding
AL475_07345	COG3312	ion transport
AL475_07350	COG0356	it plays a direct role in the translocation of protons across the membrane
AL475_07360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL475_07365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL475_07375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL475_07380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL475_07385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL475_07395	COG0765	amino acid transport
AL475_07400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_07405	COG2814	Major facilitator Superfamily
AL475_07410	COG0583	DNA-binding transcription factor activity
AL475_07415	COG0183	Belongs to the thiolase family
AL475_07425	COG1739	Uncharacterized protein family UPF0029
AL475_07430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_07485	COG2132	Multicopper oxidase
AL475_07490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL475_07495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL475_07500	COG0352	thiamine-phosphate diphosphorylase activity
AL475_07505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL475_07520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL475_07525	COG0517	IMP dehydrogenase activity
AL475_07525	COG4175	Glycine betaine
AL475_07555	COG0006	proline dipeptidase activity
AL475_07555	COG0006	proline dipeptidase activity
AL475_07575	COG1522	sequence-specific DNA binding
AL475_07580	COG5001	Diguanylate cyclase
AL475_07580	COG5002	protein histidine kinase activity
AL475_07600	COG0589	response to stress
AL475_07605	COG1528	Iron-storage protein
AL475_07615	COG2081	HI0933 family
AL475_07620	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL475_07625	COG1129	ABC transporter
AL475_07630	COG1879	ABC-type sugar transport system periplasmic component
AL475_07635	COG1069	ribulokinase activity
AL475_07640	COG0235	Class ii aldolase
AL475_07645	COG2160	L-arabinose isomerase activity
AL475_07670	COG1322	Protein conserved in bacteria
AL475_07675	COG2226	methyltransferase
AL475_07680	COG3165	ubiquinone biosynthetic process from chorismate
AL475_07685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL475_07695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL475_07700	COG0805	protein transport
AL475_07705	COG0084	hydrolase, TatD family'
AL475_07715	COG0456	acetyltransferase
AL475_07720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL475_07720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL475_07725	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL475_07755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL475_07760	COG3071	HemY protein
AL475_07765	COG2959	enzyme of heme biosynthesis
AL475_07770	COG1587	Uroporphyrinogen-III synthase
AL475_07780	COG3072	Adenylate cyclase
AL475_07795	COG0019	diaminopimelate decarboxylase activity
AL475_07800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL475_07810	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL475_07815	COG1011	Hydrolase
AL475_07820	COG3287	FIST C domain
AL475_07820	COG2200	EAL domain
AL475_07820	COG2199	diguanylate cyclase activity
AL475_07840	COG0561	phosphatase activity
AL475_07845	COG2267	carboxylic ester hydrolase activity
AL475_07850	COG1280	lysine exporter protein (LysE YggA)
AL475_07855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL475_07860	COG0640	Transcriptional regulator
AL475_07865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL475_07880	COG0783	Belongs to the Dps family
AL475_07915	COG2095	MarC family integral membrane protein
AL475_07925	COG0742	ribosomal rna small subunit methyltransferase
AL475_07930	COG0552	protein localization to endoplasmic reticulum
AL475_07935	COG2884	Cell division ATP-binding protein ftsE
AL475_07940	COG2177	Part of the ABC transporter FtsEX involved in
AL475_07945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL475_07955	COG0705	Rhomboid family
AL475_07960	COG1580	Controls the rotational direction of flagella during chemotaxis
AL475_07965	COG3161	chorismate lyase activity
AL475_07970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL475_07975	COG2937	Belongs to the GPAT DAPAT family
AL475_07980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL475_07985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL475_07995	COG0534	Mate efflux family protein
AL475_08015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL475_08030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL475_08090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL475_08095	COG5001	Diguanylate cyclase
AL475_08095	COG3300	MHYT domain
AL475_08100	COG2204	response regulator
AL475_08105	COG3852	Histidine kinase
AL475_08115	COG0174	glutamine synthetase
AL475_08140	COG1490	D-aminoacyl-tRNA deacylase activity
AL475_08145	COG0456	acetyltransferase
AL475_08150	COG2982	Protein involved in outer membrane biogenesis
AL475_08155	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL475_08165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL475_08170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL475_08175	COG3031	protein transport across the cell outer membrane
AL475_08185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL475_08190	COG1459	type II secretion system
AL475_08195	COG2165	general secretion pathway protein
AL475_08200	COG2165	general secretion pathway protein
AL475_08205	COG2165	general secretion pathway protein
AL475_08210	COG4795	General secretion pathway protein
AL475_08215	COG3156	type II secretion system protein K
AL475_08220	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL475_08225	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL475_08235	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL475_08240	COG0494	nUDIX hydrolase
AL475_08245	COG0316	Belongs to the HesB IscA family
AL475_08245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL475_08250	COG1040	competence protein
AL475_08265	COG2183	response to ionizing radiation
AL475_08275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL475_08280	COG1609	Transcriptional regulator
AL475_08285	COG0129	dihydroxy-acid dehydratase activity
AL475_08290	COG3265	gluconokinase activity
AL475_08295	COG2610	gluconate transmembrane transporter activity
AL475_08300	COG0800	Aldolase
AL475_08305	COG0745	RESPONSE REGULATOR receiver
AL475_08310	COG2205	protein histidine kinase activity
AL475_08315	COG2233	PERMEase
AL475_08320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL475_08325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL475_08330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL475_08340	COG0194	GDP metabolic process
AL475_08345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL475_08350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL475_08360	COG3263	regulation of cellular component size
AL475_08370	COG4232	protein-disulfide reductase activity
AL475_08380	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL475_08385	COG0540	Belongs to the ATCase OTCase family
AL475_08395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL475_08410	COG1288	antiporter activity
AL475_08415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL475_08420	COG1027	Aspartate ammonia-lyase
AL475_08425	COG3706	GGDEF domain
AL475_08430	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL475_08435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL475_08440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL475_08445	COG2205	protein histidine kinase activity
AL475_08450	COG0745	RESPONSE REGULATOR receiver
AL475_08455	COG3678	ATP-independent chaperone mediated protein folding
AL475_08460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL475_08465	COG0205	6-phosphofructokinase activity
AL475_08470	COG1494	fructose-1,6-bisphosphatase
AL475_08480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL475_08485	COG0527	aspartate kinase activity
AL475_08485	COG0460	homoserine dehydrogenase
AL475_08490	COG0626	cystathionine gamma-synthase activity
AL475_08500	COG0281	malic enzyme
AL475_08505	COG0254	rRNA binding
AL475_08510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL475_08515	COG1609	Transcriptional regulator
AL475_08525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL475_08530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL475_08535	COG1575	Belongs to the MenA family. Type 1 subfamily
AL475_08540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_08550	COG0149	triose-phosphate isomerase activity
AL475_08575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL475_08580	COG0459	protein refolding
AL475_08585	COG1119	ATPase activity
AL475_08595	COG1285	pathogenesis
AL475_08600	COG1509	lysine 2,3-aminomutase activity
AL475_08605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL475_08610	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL475_08615	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL475_08620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL475_08625	COG1053	succinate dehydrogenase
AL475_08635	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL475_08640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL475_08645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL475_08650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL475_08655	COG1045	serine acetyltransferase
AL475_08660	COG1695	Transcriptional regulator
AL475_08665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL475_08670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL475_08675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL475_08680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL475_08690	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL475_08690	COG0165	Argininosuccinate lyase
AL475_08700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL475_08700	COG0678	peroxiredoxin activity
AL475_08710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL475_08745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL475_08755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL475_08760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL475_08770	COG0180	Tryptophanyl-tRNA synthetase
AL475_08780	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL475_08790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL475_08800	COG1012	belongs to the aldehyde dehydrogenase family
AL475_08810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL475_08815	COG3954	Phosphoribulokinase
AL475_08825	COG0429	hydrolase of the alpha beta-hydrolase fold
AL475_08835	COG0488	(ABC) transporter
AL475_08840	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL475_08850	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AL475_08855	COG1047	Peptidyl-prolyl cis-trans
AL475_08865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL475_08870	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL475_08875	COG3083	sulfuric ester hydrolase activity
AL475_08880	COG0557	exoribonuclease II activity
AL475_08885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL475_08890	COG0051	transcription antitermination factor activity, RNA binding
AL475_08895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL475_08900	COG0088	Forms part of the polypeptide exit tunnel
AL475_08905	COG0089	rRNA binding
AL475_08915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL475_08920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL475_08935	COG0255	Belongs to the universal ribosomal protein uL29 family
AL475_08945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL475_08950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL475_08955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL475_08960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL475_08965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL475_08970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL475_08975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL475_08985	COG1841	ribosomal large subunit assembly
AL475_08995	COG0201	protein transport
AL475_09010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL475_09015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL475_09020	COG0202	RNA polymerase activity
AL475_09025	COG0203	ribosomal protein L17
AL475_09035	COG0545	Peptidyl-prolyl cis-trans isomerase
AL475_09040	COG3061	Opacity-associated protein A
AL475_09045	COG0697	spore germination
AL475_09050	COG2153	protein acetylation
AL475_09055	COG0513	Belongs to the DEAD box helicase family
AL475_09065	COG0737	Belongs to the 5'-nucleotidase family
AL475_09070	COG1648	precorrin-2 dehydrogenase activity
AL475_09070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL475_09075	COG0175	sulfate reduction
AL475_09080	COG2895	sulfate adenylyltransferase (ATP) activity
AL475_09085	COG0471	metal ion transport
AL475_09085	COG0490	domain, Protein
AL475_09090	COG0529	Catalyzes the synthesis of activated sulfate
AL475_09110	COG0577	efflux transmembrane transporter activity
AL475_09110	COG1136	(ABC) transporter
AL475_09125	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL475_09130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_09135	COG0729	surface antigen
AL475_09145	COG2105	PFAM AIG2 family protein
AL475_09150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL475_09155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL475_09160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL475_09165	COG0163	prenyltransferase activity
AL475_09170	COG4143	(ABC) transporter
AL475_09175	COG1178	ABC-type Fe3 transport system permease component
AL475_09180	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL475_09185	COG3028	Belongs to the UPF0307 family
AL475_09190	COG0312	modulator of DNA gyrase
AL475_09195	COG2239	Acts as a magnesium transporter
AL475_09200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_09210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_09215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL475_09225	COG1137	ATPase activity
AL475_09230	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL475_09240	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL475_09245	COG0517	IMP dehydrogenase activity
AL475_09245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL475_09255	COG1127	ABC transporter
AL475_09260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL475_09265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL475_09270	COG2854	intermembrane phospholipid transfer
AL475_09275	COG3113	response to antibiotic
AL475_09280	COG5007	Belongs to the BolA IbaG family
AL475_09285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL475_09290	COG0204	Acyl-transferase
AL475_09295	COG0251	oxidation-reduction process
AL475_09300	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL475_09305	COG0540	Belongs to the ATCase OTCase family
AL475_09310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL475_09315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL475_09325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL475_09335	COG0564	pseudouridine synthase activity
AL475_09340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_09345	COG0525	valine-tRNA ligase activity
AL475_09360	COG0795	lipopolysaccharide-transporting ATPase activity
AL475_09365	COG0795	lipopolysaccharide-transporting ATPase activity
AL475_09380	COG3706	GGDEF domain
AL475_09400	COG2199	diguanylate cyclase activity
AL475_09400	COG2200	EAL domain
AL475_09400	COG2203	Gaf domain
AL475_09460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL475_09465	COG0473	3-isopropylmalate dehydrogenase activity
AL475_09470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL475_09490	COG0583	DNA-binding transcription factor activity
AL475_09495	COG1022	Amp-dependent synthetase and ligase
AL475_09500	COG0028	Belongs to the TPP enzyme family
AL475_09505	COG0440	acetolactate synthase activity
AL475_09510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_09520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL475_09530	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL475_09540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL475_09545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL475_09560	COG0354	folic acid binding
AL475_09565	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL475_09575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL475_09580	COG1595	DNA-templated transcription, initiation
AL475_09595	COG3086	response to oxidative stress
AL475_09600	COG0481	GTPase activity
AL475_09605	COG0681	Belongs to the peptidase S26 family
AL475_09610	COG0571	ribonuclease III activity
AL475_09615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL475_09620	COG1381	Involved in DNA repair and RecF pathway recombination
AL475_09625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL475_09630	COG0736	holo-[acyl-carrier-protein] synthase activity
AL475_09640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL475_09645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL475_09650	COG3956	TIGRFAM MazG family protein
AL475_09655	COG0504	CTP synthase activity
AL475_09660	COG0148	phosphopyruvate hydratase activity
AL475_09665	COG0617	tRNA 3'-terminal CCA addition
AL475_09670	COG3267	Type II secretory pathway component ExeA
AL475_09670	COG3409	Peptidoglycan-binding domain 1 protein
AL475_09680	COG4991	sh3 domain protein
AL475_09685	COG0306	phosphate transporter
AL475_09690	COG1392	Phosphate transport regulator
AL475_09695	COG3025	triphosphatase activity
AL475_09700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL475_09710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL475_09715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL475_09715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL475_09720	COG1538	Outer membrane efflux protein
AL475_09725	COG0494	nUDIX hydrolase
AL475_09730	COG3151	Protein conserved in bacteria
AL475_09740	COG3150	esterase
AL475_09745	COG0187	DNA topoisomerase II activity
AL475_09750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL475_09755	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL475_09760	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL475_09775	COG1459	type II secretion system
AL475_09800	COG0716	FMN binding
AL475_09805	COG4974	Belongs to the 'phage' integrase family
AL475_09810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL475_09815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL475_09820	COG2186	Transcriptional regulator
AL475_09825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL475_09830	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL475_09835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL475_09850	COG0288	reversible hydration of carbon dioxide
AL475_09855	COG1131	(ABC) transporter
AL475_09860	COG0842	Transport permease protein
AL475_09865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL475_09870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL475_09875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL475_09885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL475_09890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL475_09895	COG1489	DNA binding
AL475_09900	COG1643	Atp-dependent helicase
AL475_09905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL475_09910	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL475_09915	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL475_09920	COG3112	Uncharacterised protein family (UPF0231)
AL475_09925	COG0347	Belongs to the P(II) protein family
AL475_09930	COG0004	ammonium transporteR
AL475_09935	COG1840	ABC-type Fe3 transport system, periplasmic component
AL475_09945	COG3842	ATPase activity
AL475_09950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL475_09965	COG2971	BadF BadG BcrA BcrD
AL475_09975	COG4608	Belongs to the ABC transporter superfamily
AL475_09980	COG0444	Belongs to the ABC transporter superfamily
AL475_09985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_09995	COG0747	negative chemotaxis
AL475_10010	COG0628	permease
AL475_10015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL475_10020	COG0316	Belongs to the HesB IscA family
AL475_10035	COG0739	heme binding
AL475_10040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL475_10050	COG2239	Acts as a magnesium transporter
AL475_10055	COG2027	D-alanyl-D-alanine carboxypeptidase
AL475_10060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL475_10065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL475_10070	COG1534	Rna-binding protein
AL475_10080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL475_10085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL475_10090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL475_10095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL475_10110	COG0779	Required for maturation of 30S ribosomal subunits
AL475_10115	COG0195	Participates in both transcription termination and antitermination
AL475_10125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL475_10130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL475_10155	COG0534	Mate efflux family protein
AL475_10180	COG3153	acetyltransferase
AL475_10200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL475_10205	COG0513	Belongs to the DEAD box helicase family
AL475_10225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL475_10230	COG2204	response regulator
AL475_10240	COG0667	Aldo Keto reductase
AL475_10250	COG3066	DNA modification
AL475_10255	COG0494	nUDIX hydrolase
AL475_10265	COG0730	response to heat
AL475_10275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL475_10280	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL475_10285	COG0583	DNA-binding transcription factor activity
AL475_10290	COG0640	Transcriptional regulator
AL475_10300	COG0728	peptidoglycan biosynthetic process
AL475_10305	COG0196	riboflavin kinase activity
AL475_10310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL475_10315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL475_10320	COG1047	Peptidyl-prolyl cis-trans
AL475_10325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL475_10330	COG1966	Carbon starvation protein
AL475_10345	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL475_10350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL475_10360	COG3279	Response regulator of the LytR AlgR family
AL475_10365	COG3275	phosphorelay sensor kinase activity
AL475_10370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_10375	COG1605	Chorismate mutase
AL475_10375	COG0287	Prephenate dehydrogenase
AL475_10385	COG0488	(ABC) transporter
AL475_10400	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL475_10405	COG5001	Diguanylate cyclase
AL475_10410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL475_10415	COG1605	Chorismate mutase
AL475_10415	COG0077	Prephenate dehydratase
AL475_10420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL475_10425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL475_10430	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL475_10435	COG0564	pseudouridine synthase activity
AL475_10445	COG0542	response to heat
AL475_10455	COG0590	tRNA wobble adenosine to inosine editing
AL475_10460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL475_10465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AL475_10545	COG0271	Belongs to the BolA IbaG family
AL475_10550	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL475_10555	COG1805	sodium ion transport
AL475_10565	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL475_10570	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL475_10575	COG2871	sodium ion transport
AL475_10580	COG1477	protein flavinylation
AL475_10595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL475_10610	COG0733	neurotransmitter:sodium symporter activity
AL475_10620	COG0189	ligase activity
AL475_10625	COG0189	ligase activity
AL475_10625	COG4067	protein conserved in archaea
AL475_10630	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL475_10635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_10640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL475_10650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL475_10660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL475_10665	COG2252	PERMEase
AL475_10670	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL475_10685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL475_10690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL475_10695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL475_10700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL475_10700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL475_10720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL475_10725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL475_10730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL475_10740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL475_10745	COG0024	Methionine aminopeptidase
AL475_10770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL475_10775	COG0575	Belongs to the CDS family
AL475_10780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL475_10785	COG0750	zinc metalloprotease
AL475_10795	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL475_10800	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL475_10805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL475_10825	COG0587	DNA-directed DNA polymerase activity
AL475_10830	COG0825	malonyl-CoA metabolic process
AL475_10835	COG0037	tRNA processing
AL475_10845	COG0347	Belongs to the P(II) protein family
AL475_10860	COG0741	lytic transglycosylase activity
AL475_10860	COG1388	LysM domain
AL475_10870	COG2226	methyltransferase
AL475_10875	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_10880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL475_10890	COG1960	acyl-CoA dehydrogenase activity
AL475_10895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL475_10900	COG0121	glutamine amidotransferase
AL475_10905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL475_10910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL475_10915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL475_10920	COG1187	pseudouridine synthase activity
AL475_10955	COG2608	mercury ion transmembrane transporter activity
AL475_10955	COG2217	Heavy metal translocating P-type atpase
AL475_10960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL475_10980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL475_10985	COG2194	sulfuric ester hydrolase activity
AL475_11075	COG4695	Portal protein
AL475_11105	COG2747	anti-sigma28 factor FlgM
AL475_11115	COG0835	chemotaxis
AL475_11115	COG0784	Response regulator, receiver
AL475_11120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL475_11125	COG1815	bacterial-type flagellum-dependent cell motility
AL475_11130	COG1558	bacterial-type flagellum-dependent cell motility
AL475_11135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL475_11140	COG1749	Flagellar hook protein flgE
AL475_11145	COG4787	bacterial-type flagellum-dependent cell motility
AL475_11150	COG4786	Flagellar basal body rod
AL475_11155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL475_11160	COG1706	bacterial-type flagellum-dependent cell motility
AL475_11165	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL475_11165	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL475_11185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_11285	COG0193	aminoacyl-tRNA hydrolase activity
AL475_11290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL475_11300	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL475_11305	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL475_11310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL475_11315	COG2890	protein-(glutamine-N5) methyltransferase activity
AL475_11320	COG3094	Invasion gene expression up-regulator, SirB
AL475_11325	COG2912	Transglutaminase-like superfamily
AL475_11335	COG0737	Belongs to the 5'-nucleotidase family
AL475_11345	COG2233	PERMEase
AL475_11365	COG1393	Belongs to the ArsC family
AL475_11370	COG4783	chaperone-mediated protein folding
AL475_11390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL475_11395	COG2716	regulation of RNA biosynthetic process
AL475_11400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL475_11405	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL475_11415	COG1876	peptidase activity
AL475_11420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL475_11425	COG1393	Belongs to the ArsC family
AL475_11435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL475_11445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL475_11465	COG2837	iron assimilation
AL475_11475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_11480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_11485	COG1334	flagellar protein FlaG
AL475_11490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL475_11500	COG1516	flagellar protein fliS
AL475_11510	COG4191	Histidine kinase
AL475_11515	COG2204	response regulator
AL475_11520	COG1677	Flagellar hook-basal body complex protein FliE
AL475_11530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL475_11580	COG1987	bacterial-type flagellum assembly
AL475_11600	COG2890	protein-(glutamine-N5) methyltransferase activity
AL475_11605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL475_11610	COG0583	DNA-binding transcription factor activity
AL475_11615	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_11620	COG2860	membrane
AL475_11625	COG3101	peptidyl-lysine hydroxylation
AL475_11640	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL475_11640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL475_11645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL475_11650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_11655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL475_11660	COG0735	belongs to the Fur family
AL475_11670	COG0583	DNA-binding transcription factor activity
AL475_11675	COG1380	Effector of murein hydrolase LrgA
AL475_11680	COG1346	cytolysis
AL475_11695	COG0596	Alpha beta hydrolase
AL475_11700	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL475_11705	COG0033	Phosphoglucomutase
AL475_11715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL475_11725	COG2009	succinate dehydrogenase
AL475_11730	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL475_11745	COG0567	Dehydrogenase, E1 component
AL475_11750	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL475_11765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL475_11770	COG1121	(ABC) transporter
AL475_11775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL475_11790	COG1918	ferrous iron import across plasma membrane
AL475_11810	COG0018	arginyl-trna synthetase
AL475_11815	COG3102	Protein conserved in bacteria
AL475_11825	COG2062	phosphohistidine phosphatase, SixA
AL475_11840	COG0455	bacterial-type flagellum organization
AL475_11855	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL475_11860	COG0643	Histidine kinase
AL475_11860	COG2198	Histidine kinase
AL475_11865	COG2201	protein-glutamate methylesterase activity
AL475_11870	COG1192	Involved in chromosome partitioning
AL475_11880	COG0835	chemotaxis
AL475_11890	COG4133	protoheme IX ABC transporter activity
AL475_11895	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL475_11900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL475_11905	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL475_11910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL475_11915	COG1138	Cytochrome C-type biogenesis protein
AL475_11920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL475_11935	COG2853	Lipoprotein
AL475_11955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL475_11960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL475_11965	COG3384	dioxygenase
AL475_11990	COG0667	Aldo Keto reductase
AL475_12005	COG0583	DNA-binding transcription factor activity
AL475_12010	COG2159	amidohydrolase
AL475_12015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_12055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL475_12070	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL475_12080	COG1448	Aminotransferase
AL475_12095	COG3083	sulfuric ester hydrolase activity
AL475_12105	COG3081	Nucleoid-associated protein
AL475_12115	COG1757	Na H antiporter
AL475_12120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL475_12125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL475_12130	COG2095	MarC family integral membrane protein
AL475_12135	COG1454	alcohol dehydrogenase
AL475_12135	COG1012	belongs to the aldehyde dehydrogenase family
AL475_12145	COG0659	secondary active sulfate transmembrane transporter activity
AL475_12155	COG1530	ribonuclease E activity
AL475_12160	COG0564	pseudouridine synthase activity
AL475_12165	COG0424	maF-like protein
AL475_12170	COG1399	metal-binding, possibly nucleic acid-binding protein
AL475_12180	COG0416	fatty acid biosynthetic process
AL475_12185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL475_12205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL475_12210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL475_12215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL475_12220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL475_12225	COG0470	DNA polymerase III
AL475_12230	COG0084	hydrolase, TatD family'
AL475_12235	COG2190	(PTS) system
AL475_12235	COG1263	PTS System
AL475_12235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_12245	COG1263	PTS System
AL475_12245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_12255	COG0733	neurotransmitter:sodium symporter activity
AL475_12270	COG4667	esterase of the alpha-beta hydrolase superfamily
AL475_12280	COG1940	carbohydrate kinase activity
AL475_12285	COG0784	Response regulator, receiver
AL475_12285	COG0835	chemotaxis
AL475_12290	COG0587	DNA-directed DNA polymerase activity
AL475_12305	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_12310	COG0616	signal peptide processing
AL475_12320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL475_12320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL475_12340	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL475_12345	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL475_12350	COG0436	Aminotransferase
AL475_12355	COG1169	isochorismate synthase
AL475_12360	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL475_12365	COG0596	Alpha beta hydrolase
AL475_12370	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL475_12375	COG1441	menaquinone biosynthetic process
AL475_12390	COG2855	membrane
AL475_12395	COG0477	Major facilitator Superfamily
AL475_12415	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AL475_12420	COG1388	LysM domain
AL475_12420	COG0741	lytic transglycosylase activity
AL475_12440	COG1815	bacterial-type flagellum-dependent cell motility
AL475_12445	COG1558	bacterial-type flagellum-dependent cell motility
AL475_12450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL475_12455	COG1749	Flagellar hook protein flgE
AL475_12465	COG4786	Flagellar basal body rod
AL475_12470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL475_12475	COG1706	bacterial-type flagellum-dependent cell motility
AL475_12485	COG1256	bacterial-type flagellum assembly
AL475_12485	COG4786	Flagellar basal body rod
AL475_12535	COG0702	epimerase
AL475_12540	COG3015	lipoprotein NlpE involved in copper resistance
AL475_12550	COG1360	Flagellar Motor Protein
AL475_12555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL475_12560	COG1191	sigma factor activity
AL475_12565	COG1580	Controls the rotational direction of flagella during chemotaxis
AL475_12585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL475_12590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL475_12605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL475_12615	COG1987	bacterial-type flagellum assembly
AL475_12635	COG2885	chlorophyll binding
AL475_12640	COG2204	response regulator
AL475_12655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL475_12680	COG1522	sequence-specific DNA binding
AL475_12685	COG1946	Acyl-CoA thioesterase
AL475_12690	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL475_12705	COG2203	Gaf domain
AL475_12705	COG2199	diguanylate cyclase activity
AL475_12730	COG0431	NADPH-dependent FMN reductase
AL475_12735	COG0697	spore germination
AL475_12745	COG1278	Cold shock
AL475_12780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL475_12785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_12790	COG1881	PFAM PEBP family protein
AL475_12795	COG2207	Transcriptional regulator
AL475_12825	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL475_12830	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_12845	COG0642	Histidine kinase
AL475_12850	COG0745	RESPONSE REGULATOR receiver
AL475_12855	COG0671	phosphoesterase, PA-phosphatase related
AL475_12865	COG0513	Belongs to the DEAD box helicase family
AL475_12870	COG1368	sulfuric ester hydrolase activity
AL475_12875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL475_12880	COG2194	sulfuric ester hydrolase activity
AL475_12905	COG4566	intracellular signal transduction
AL475_12930	COG2863	cytochrome
AL475_12935	COG3258	Cytochrome c
AL475_12950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_12955	COG1271	oxidase subunit
AL475_12960	COG1294	oxidase, subunit
AL475_13000	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL475_13005	COG2814	Major facilitator Superfamily
AL475_13015	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL475_13020	COG1169	isochorismate synthase
AL475_13025	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_13030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_13035	COG3433	isochorismatase activity
AL475_13035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL475_13035	COG2226	methyltransferase
AL475_13050	COG4592	Periplasmic binding protein
AL475_13055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_13060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_13065	COG4774	siderophore transport
AL475_13065	COG1629	transport
AL475_13075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL475_13080	COG1120	ATPase activity
AL475_13090	COG1609	Transcriptional regulator
AL475_13095	COG2723	6-phospho-beta-galactosidase activity
AL475_13100	COG1741	Belongs to the pirin family
AL475_13105	COG0352	thiamine-phosphate diphosphorylase activity
AL475_13115	COG0351	phosphomethylpyrimidine kinase
AL475_13120	COG4172	Belongs to the ABC transporter superfamily
AL475_13125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_13130	COG0601	transmembrane transport
AL475_13135	COG0747	negative chemotaxis
AL475_13145	COG1538	Outer membrane efflux protein
AL475_13150	COG1566	PFAM secretion protein HlyD family protein
AL475_13155	COG2814	Major facilitator Superfamily
AL475_13160	COG3708	Transcriptional regulator
AL475_13160	COG2207	Transcriptional regulator
AL475_13170	COG0745	RESPONSE REGULATOR receiver
AL475_13180	COG1263	PTS System
AL475_13180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL475_13190	COG1621	beta-fructofuranosidase activity
AL475_13195	COG2202	Pas domain
AL475_13195	COG2200	EAL domain
AL475_13195	COG2199	diguanylate cyclase activity
AL475_13205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_13220	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_13255	COG2986	histidine ammonia-lyase
AL475_13260	COG1216	Glycosyl transferase, family 2
AL475_13280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL475_13285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL475_13320	COG0601	transmembrane transport
AL475_13325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL475_13330	COG0444	Belongs to the ABC transporter superfamily
AL475_13345	COG0435	Glutathione S-transferase
AL475_13350	COG3174	membrane
AL475_13355	COG0280	phosphate acetyltransferase
AL475_13355	COG0857	belongs to the CobB CobQ family
AL475_13360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL475_13365	COG3092	negative regulation of chromosome organization
AL475_13375	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL475_13385	COG3706	GGDEF domain
AL475_13400	COG0653	protein targeting
AL475_13405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL475_13410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL475_13415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL475_13425	COG0243	molybdopterin cofactor binding
AL475_13430	COG1648	precorrin-2 dehydrogenase activity
AL475_13430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL475_13445	COG1116	anion transmembrane transporter activity
AL475_13445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL475_13450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL475_13455	COG1116	anion transmembrane transporter activity
AL475_13460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL475_13460	COG2146	nitrite reductase [NAD(P)H] activity
AL475_13470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL475_13475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL475_13480	COG0156	8-amino-7-oxononanoate synthase activity
AL475_13485	COG2226	methyltransferase
AL475_13490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL475_13495	COG0501	Belongs to the peptidase M48B family
AL475_13505	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_13520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL475_13540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL475_13545	COG2915	High frequency lysogenization protein hflD homolog
AL475_13550	COG0482	sulfurtransferase activity
AL475_13555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_13560	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL475_13565	COG1757	Na H antiporter
AL475_13575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL475_13580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL475_13585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL475_13590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL475_13590	COG0131	Imidazoleglycerol-phosphate dehydratase
AL475_13595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL475_13600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL475_13610	COG0140	phosphoribosyl-ATP diphosphatase activity
AL475_13610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL475_13615	COG1187	pseudouridine synthase activity
AL475_13625	COG1278	Cold shock
AL475_13630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL475_13635	COG0542	response to heat
AL475_13640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL475_13645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL475_13650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL475_13660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL475_13670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL475_13675	COG3706	GGDEF domain
AL475_13675	COG0745	RESPONSE REGULATOR receiver
AL475_13680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL475_13685	COG0297	glycogen (starch) synthase activity
AL475_13705	COG3070	regulator of competence-specific genes
AL475_13710	COG1609	Transcriptional regulator
AL475_13715	COG3381	protein complex oligomerization
AL475_13720	COG0745	RESPONSE REGULATOR receiver
AL475_13725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL475_13730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL475_13735	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL475_13740	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL475_13745	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL475_13750	COG0189	ligase activity
AL475_13760	COG4067	protein conserved in archaea
AL475_13760	COG0189	ligase activity
AL475_13765	COG0500	methyltransferase
AL475_13770	COG4106	trans-aconitate 2-methyltransferase activity
AL475_13785	COG1435	thymidine kinase activity
AL475_13790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL475_13795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL475_13815	COG2116	formate transmembrane transporter activity
AL475_13820	COG0390	transport system, permease component
AL475_13825	COG4459	periplasmic nitrate reductase
AL475_13830	COG3005	denitrification pathway
AL475_13835	COG0243	molybdopterin cofactor binding
AL475_13855	COG1227	inorganic diphosphatase activity
AL475_13870	COG4172	Belongs to the ABC transporter superfamily
AL475_13880	COG4171	peptide transport system, permease
AL475_13885	COG4168	peptide transport system, permease
AL475_13895	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL475_13900	COG1842	Phage shock protein A
AL475_13915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_13930	COG0519	Catalyzes the synthesis of GMP from XMP
AL475_13945	COG4232	protein-disulfide reductase activity
AL475_13960	COG0626	cystathionine gamma-synthase activity
AL475_13970	COG0733	neurotransmitter:sodium symporter activity
AL475_13990	COG0564	pseudouridine synthase activity
AL475_14000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL475_14005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL475_14010	COG4136	ATPase activity
AL475_14015	COG4135	transport system, permease component
AL475_14020	COG4134	Bacterial extracellular solute-binding protein
AL475_14030	COG3313	Fe-S protein
AL475_14040	COG0842	Transport permease protein
AL475_14045	COG1131	(ABC) transporter
AL475_14055	COG0814	amino acid
AL475_14070	COG3706	GGDEF domain
AL475_14075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL475_14085	COG1278	Cold shock
AL475_14095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_14105	COG3119	arylsulfatase activity
AL475_14110	COG0641	radical SAM
AL475_14115	COG0714	Associated with various cellular activities
AL475_14150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL475_14155	COG2205	protein histidine kinase activity
AL475_14160	COG0745	RESPONSE REGULATOR receiver
AL475_14170	COG1061	Type III restriction enzyme res subunit
AL475_14180	COG2814	Major facilitator Superfamily
AL475_14190	COG0702	epimerase
AL475_14195	COG0534	Mate efflux family protein
AL475_14200	COG4181	ATPase activity
AL475_14215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL475_14265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_14280	COG3265	gluconokinase activity
AL475_14285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL475_14315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL475_14335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL475_14360	COG2989	Protein conserved in bacteria
AL475_14365	COG3108	Peptidase M15
AL475_14370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL475_14385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_14405	COG2197	response regulator
AL475_14410	COG1846	Transcriptional regulator
AL475_14415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_14420	COG0840	transmembrane signaling receptor activity
AL475_14425	COG2176	DNA-directed DNA polymerase activity
AL475_14430	COG0517	IMP dehydrogenase activity
AL475_14430	COG0516	GMP reductase activity
AL475_14440	COG1448	Aminotransferase
AL475_14460	COG0840	transmembrane signaling receptor activity
AL475_14465	COG0720	synthase
AL475_14470	COG1538	Outer membrane efflux protein
AL475_14475	COG1136	(ABC) transporter
AL475_14475	COG0577	efflux transmembrane transporter activity
AL475_14480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL475_14485	COG1760	l-serine dehydratase
AL475_14490	COG0814	amino acid
AL475_14495	COG0494	nUDIX hydrolase
AL475_14510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL475_14525	COG3106	COG3106 Predicted ATPase
AL475_14535	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AL475_14540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_14560	COG0471	metal ion transport
AL475_14565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_14565	COG4191	Histidine kinase
AL475_14575	COG0583	DNA-binding transcription factor activity
AL475_14580	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL475_14585	COG0778	Nitroreductase
AL475_14590	COG2991	Protein conserved in bacteria
AL475_14600	COG3250	beta-galactosidase activity
AL475_14610	COG1129	ABC transporter
AL475_14645	COG2169	Transcriptional regulator
AL475_14645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL475_14655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL475_14660	COG0372	Belongs to the citrate synthase family
AL475_14665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL475_14670	COG2828	Protein conserved in bacteria
AL475_14685	COG1566	PFAM secretion protein HlyD family protein
AL475_14690	COG2814	Major facilitator Superfamily
AL475_14705	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL475_14710	COG2200	EAL domain
AL475_14720	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL475_14730	COG0625	glutathione transferase activity
AL475_14750	COG2731	YhcH YjgK YiaL family protein
AL475_14760	COG0584	glycerophosphoryl diester phosphodiesterase
AL475_14765	COG1349	DNA-binding transcription factor activity
AL475_14770	COG3842	ATPase activity
AL475_14775	COG0395	ABC-type sugar transport system, permease component
AL475_14795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL475_14800	COG3040	lipid binding
AL475_14810	COG0811	peptide transport
AL475_14815	COG0811	peptide transport
AL475_14820	COG0848	biopolymer transport protein
AL475_14840	COG4667	esterase of the alpha-beta hydrolase superfamily
AL475_14845	COG1793	dna ligase
AL475_14860	COG0307	riboflavin synthase, alpha
AL475_14880	COG0791	NLP P60 protein
AL475_14885	COG0840	transmembrane signaling receptor activity
AL475_14900	COG1940	carbohydrate kinase activity
AL475_14910	COG0303	'Molybdopterin
AL475_14915	COG0746	molybdenum cofactor guanylyltransferase activity
AL475_14920	COG3842	ATPase activity
AL475_14925	COG4662	Binding-protein-dependent transport system inner membrane component
AL475_14935	COG2204	response regulator
AL475_14940	COG3852	Histidine kinase
AL475_14955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL475_14975	COG3381	protein complex oligomerization
AL475_14985	COG3604	Transcriptional regulator
AL475_14995	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL475_15000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL475_15010	COG0366	Alpha amylase catalytic
AL475_15030	COG0714	Associated with various cellular activities
AL475_15065	COG3706	GGDEF domain
AL475_15075	COG0784	Response regulator, receiver
AL475_15075	COG5002	protein histidine kinase activity
AL475_15075	COG2205	protein histidine kinase activity
AL475_15080	COG3706	GGDEF domain
AL475_15080	COG0745	RESPONSE REGULATOR receiver
AL475_15090	COG3724	N-succinylarginine dihydrolase activity
AL475_15095	COG1012	belongs to the aldehyde dehydrogenase family
AL475_15120	COG4948	Mandelate Racemase Muconate Lactonizing
AL475_15145	COG0583	DNA-binding transcription factor activity
AL475_15170	COG3171	Protein conserved in bacteria
AL475_15175	COG0589	response to stress
AL475_15185	COG3530	Putative quorum-sensing-regulated virulence factor
AL475_15195	COG0579	oxidoreductase
AL475_15210	COG2204	response regulator
AL475_15220	COG1929	Belongs to the glycerate kinase type-1 family
AL475_15225	COG0383	alpha-mannosidase activity
AL475_15230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_15230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_15230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_15235	COG2188	Transcriptional regulator
AL475_15260	COG5001	Diguanylate cyclase
AL475_15260	COG3300	MHYT domain
AL475_15265	COG2271	Major facilitator Superfamily
AL475_15270	COG0584	glycerophosphoryl diester phosphodiesterase
AL475_15275	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL475_15280	COG0583	DNA-binding transcription factor activity
AL475_15290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_15295	COG1879	ABC-type sugar transport system periplasmic component
AL475_15300	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL475_15305	COG1129	ABC transporter
AL475_15310	COG1869	D-ribose catabolic process
AL475_15330	COG3501	Rhs element vgr protein
AL475_15425	COG1280	lysine exporter protein (LysE YggA)
AL475_15430	COG1846	Transcriptional regulator
AL475_15435	COG1230	cation diffusion facilitator family transporter
AL475_15445	COG0564	pseudouridine synthase activity
AL475_15450	COG1309	transcriptional regulator
AL475_15455	COG2130	NADP-dependent
AL475_15470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_15500	COG3842	ATPase activity
AL475_15510	COG2200	EAL domain
AL475_15515	COG0656	L-ascorbic acid biosynthetic process
AL475_15520	COG1902	pentaerythritol trinitrate reductase activity
AL475_15525	COG0583	DNA-binding transcription factor activity
AL475_15530	COG2814	Major facilitator Superfamily
AL475_15550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL475_15565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL475_15575	COG4702	Belongs to the UPF0303 family
AL475_15580	COG0673	inositol 2-dehydrogenase activity
AL475_15585	COG1349	DNA-binding transcription factor activity
AL475_15590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL475_15610	COG3240	lipase activity
AL475_15615	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_15620	COG0583	DNA-binding transcription factor activity
AL475_15630	COG1120	ATPase activity
AL475_15635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_15640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_15645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL475_15650	COG4774	siderophore transport
AL475_15675	COG0840	transmembrane signaling receptor activity
AL475_15680	COG3384	dioxygenase
AL475_15685	COG0583	DNA-binding transcription factor activity
AL475_15695	COG1342	Belongs to the UPF0251 family
AL475_15700	COG0778	Nitroreductase
AL475_15705	COG0583	DNA-binding transcription factor activity
AL475_15715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL475_15720	COG0697	spore germination
AL475_15735	COG2814	Major facilitator Superfamily
AL475_15740	COG0583	DNA-binding transcription factor activity
AL475_15745	COG3300	MHYT domain
AL475_15745	COG5001	Diguanylate cyclase
AL475_15750	COG0739	heme binding
AL475_15765	COG0659	secondary active sulfate transmembrane transporter activity
AL475_15780	COG2199	diguanylate cyclase activity
AL475_15790	COG0581	inorganic phosphate transmembrane transporter activity
AL475_15795	COG0573	inorganic phosphate transmembrane transporter activity
AL475_15800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL475_15805	COG0840	transmembrane signaling receptor activity
AL475_15810	COG0513	Belongs to the DEAD box helicase family
AL475_15820	COG1376	ErfK ybiS ycfS ynhG family protein
AL475_15820	COG1388	LysM domain
AL475_15825	COG0415	Belongs to the DNA photolyase family
AL475_15835	COG3272	Protein of unknown function (DUF1722)
AL475_15840	COG0813	purine-nucleoside phosphorylase activity
AL475_15855	COG3706	GGDEF domain
AL475_15865	COG1566	PFAM secretion protein HlyD family protein
AL475_15900	COG0786	glutamate:sodium symporter activity
AL475_15915	COG1999	signal sequence binding
AL475_15925	COG1162	GTPase activity
AL475_15930	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL475_15945	COG4580	involved in the transport of maltose and maltodextrins
AL475_15960	COG1132	(ABC) transporter
AL475_15965	COG4974	Belongs to the 'phage' integrase family
AL475_15975	COG0326	Molecular chaperone. Has ATPase activity
AL475_16130	COG4695	Portal protein
AL475_16170	COG4386	tail sheath protein
AL475_16205	COG0671	phosphoesterase, PA-phosphatase related
AL475_16215	COG3383	formate dehydrogenase (NAD+) activity
AL475_16230	COG0840	transmembrane signaling receptor activity
AL475_16240	COG1131	(ABC) transporter
AL475_16245	COG2188	Transcriptional regulator
AL475_16255	COG3033	Beta-eliminating lyase
AL475_16260	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL475_16265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_16275	COG0471	metal ion transport
AL475_16300	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AL475_16320	COG3501	Rhs element vgr protein
AL475_16330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL475_16335	COG1640	4-alpha-glucanotransferase
AL475_16340	COG0058	SHG alpha-glucan phosphorylase activity
AL475_16345	COG2909	trisaccharide binding
AL475_16360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL475_16365	COG1845	cytochrome c oxidase, subunit III
AL475_16370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL475_16375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL475_16390	COG2084	Dehydrogenase
AL475_16405	COG0217	transcriptional regulatory protein
AL475_16440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL475_16445	COG1444	tRNA N-acetyltransferase activity
AL475_16455	COG0745	RESPONSE REGULATOR receiver
AL475_16465	COG0835	chemotaxis
AL475_16470	COG0835	chemotaxis
AL475_16475	COG0840	transmembrane signaling receptor activity
AL475_16480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL475_16490	COG2201	protein-glutamate methylesterase activity
AL475_16505	COG0745	RESPONSE REGULATOR receiver
AL475_16535	COG0259	pyridoxamine-phosphate oxidase activity
AL475_16545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL475_16580	COG0840	transmembrane signaling receptor activity
AL475_16595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL475_16600	COG0859	PFAM glycosyl transferase family 9
AL475_16605	COG0513	Belongs to the DEAD box helicase family
AL475_16615	COG0583	DNA-binding transcription factor activity
AL475_16620	COG2226	methyltransferase
AL475_16635	COG0724	RNA recognition motif
AL475_16640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL475_16645	COG1522	sequence-specific DNA binding
AL475_16650	COG2610	gluconate transmembrane transporter activity
AL475_16655	COG3622	Belongs to the hyi family
AL475_16660	COG0235	Class ii aldolase
AL475_16665	COG3395	kinase activity
AL475_16670	COG2084	Dehydrogenase
AL475_16675	COG1349	DNA-binding transcription factor activity
AL475_16690	COG0583	DNA-binding transcription factor activity
AL475_16695	COG2910	NAD(P)H-binding
AL475_16710	COG1335	isochorismatase
AL475_16715	COG2207	Transcriptional regulator
AL475_16715	COG1609	Transcriptional regulator
AL475_16730	COG2329	Antibiotic biosynthesis monooxygenase
AL475_16735	COG3304	Inner membrane component domain
AL475_16745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_16775	COG0583	DNA-binding transcription factor activity
AL475_16780	COG4221	oxidoreductase activity
AL475_16800	COG1403	HNH endonuclease
AL475_16810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_16835	COG2176	DNA-directed DNA polymerase activity
AL475_16855	COG0443	Heat shock 70 kDa protein
AL475_16860	COG0095	Lipoate-protein ligase
AL475_16875	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_16880	COG1473	amidohydrolase
AL475_16895	COG3722	fumarate hydratase activity
AL475_16905	COG2213	PTS system mannitol-specific
AL475_16905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_16915	COG0739	heme binding
AL475_16930	COG0363	glucosamine-6-phosphate deaminase activity
AL475_16955	COG0402	S-adenosylhomocysteine deaminase activity
AL475_16960	COG2259	Doxx family
AL475_16965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL475_16970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL475_16980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL475_16985	COG1301	dicarboxylic acid transport
AL475_17040	COG1764	response to oxidative stress
AL475_17045	COG1846	Transcriptional regulator
AL475_17050	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL475_17070	COG1280	lysine exporter protein (LysE YggA)
AL475_17080	COG1902	pentaerythritol trinitrate reductase activity
AL475_17085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL475_17095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL475_17125	COG1612	heme a metabolic process
AL475_17130	COG0109	protoheme IX farnesyltransferase activity
AL475_17145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL475_17155	COG5001	Diguanylate cyclase
AL475_17155	COG5002	protein histidine kinase activity
AL475_17155	COG3447	MASE1 domain protein
AL475_17175	COG2169	Transcriptional regulator
AL475_17195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_17200	COG0697	spore germination
AL475_17205	COG0477	Major facilitator Superfamily
AL475_17210	COG0625	glutathione transferase activity
AL475_17215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL475_17225	COG1942	4-Oxalocrotonate Tautomerase
AL475_17240	COG0583	DNA-binding transcription factor activity
AL475_17265	COG3152	Membrane
AL475_17285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL475_17310	COG1304	FMN binding
AL475_17315	COG1620	l-lactate permease
AL475_17325	COG0583	DNA-binding transcription factor activity
AL475_17330	COG4172	Belongs to the ABC transporter superfamily
AL475_17340	COG1067	ATP-dependent peptidase activity
AL475_17345	COG0840	transmembrane signaling receptor activity
AL475_17350	COG2211	Major facilitator Superfamily
AL475_17355	COG0668	transmembrane transport
AL475_17360	COG0569	domain protein
AL475_17365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL475_17380	COG3123	guanosine phosphorylase activity
AL475_17390	COG2814	Major facilitator Superfamily
AL475_17400	COG3501	Rhs element vgr protein
AL475_17505	COG0745	RESPONSE REGULATOR receiver
AL475_17510	COG1741	Belongs to the pirin family
AL475_17545	COG3706	GGDEF domain
AL475_17565	COG3706	GGDEF domain
AL475_17575	COG1846	Transcriptional regulator
AL475_17580	COG2315	Protein conserved in bacteria
AL475_17585	COG0784	Response regulator, receiver
AL475_17585	COG0835	chemotaxis
AL475_17590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL475_17615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL475_17635	COG1522	sequence-specific DNA binding
AL475_17645	COG0393	Putative heavy-metal-binding
AL475_17650	COG0823	Involved in the tonB-independent uptake of proteins
AL475_17655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL475_17660	COG0534	Mate efflux family protein
AL475_17670	COG1653	transport
AL475_17675	COG3842	ATPase activity
AL475_17680	COG0395	ABC-type sugar transport system, permease component
AL475_17685	COG1175	transmembrane transport
AL475_17700	COG0840	transmembrane signaling receptor activity
AL475_17710	COG0800	Aldolase
AL475_17715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_17730	COG1917	Cupin 2, conserved barrel domain protein
AL475_17740	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_17745	COG1414	Transcriptional regulator
AL475_17750	COG0517	IMP dehydrogenase activity
AL475_17770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_17780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_17820	COG3842	ATPase activity
AL475_17860	COG1349	DNA-binding transcription factor activity
AL475_17880	COG2354	Protein conserved in bacteria
AL475_17885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL475_17890	COG0418	dihydroorotase activity
AL475_17900	COG0633	Ferredoxin
AL475_17900	COG3217	Mosc domain protein beta barrel domain protein
AL475_17930	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL475_17935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_17945	COG0848	biopolymer transport protein
AL475_17950	COG0811	peptide transport
AL475_17955	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL475_17960	COG3721	Heme iron utilization protein
AL475_17965	COG0748	coenzyme F420 binding
AL475_17975	COG0531	amino acid
AL475_17980	COG1522	sequence-specific DNA binding
AL475_18010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL475_18015	COG2200	EAL domain
AL475_18045	COG5001	Diguanylate cyclase
AL475_18045	COG3300	MHYT domain
AL475_18060	COG1765	OsmC-like protein
AL475_18070	COG2171	N-acyltransferase activity
AL475_18095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL475_18125	COG0745	RESPONSE REGULATOR receiver
AL475_18130	COG0642	Histidine kinase
AL475_18140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL475_18145	COG3186	Phenylalanine-4-hydroxylase
AL475_18150	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL475_18155	COG0534	Mate efflux family protein
AL475_18165	COG0861	Integral membrane protein TerC family
AL475_18175	COG0456	acetyltransferase
AL475_18180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL475_18185	COG0662	Cupin 2, conserved barrel domain protein
AL475_18190	COG0527	aspartate kinase activity
AL475_18195	COG0561	phosphatase activity
AL475_18205	COG0583	DNA-binding transcription factor activity
AL475_18215	COG0784	Response regulator, receiver
AL475_18215	COG3437	response regulator, receiver
AL475_18225	COG0113	porphobilinogen synthase activity
AL475_18235	COG0459	protein refolding
AL475_18240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL475_18245	COG2239	Acts as a magnesium transporter
AL475_18265	COG2113	Glycine betaine
AL475_18270	COG4176	ABC-type proline glycine betaine transport system permease component
AL475_18275	COG4175	Glycine betaine
AL475_18285	COG1166	arginine decarboxylase activity
AL475_18295	COG1522	sequence-specific DNA binding
AL475_18310	COG0765	amino acid transport
AL475_18320	COG1686	Belongs to the peptidase S11 family
AL475_18335	COG1566	PFAM secretion protein HlyD family protein
AL475_18345	COG3338	carbonate dehydratase activity
AL475_18380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL475_18390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL475_18400	COG1280	lysine exporter protein (LysE YggA)
AL475_18405	COG0513	Belongs to the DEAD box helicase family
AL475_18420	COG0840	transmembrane signaling receptor activity
AL475_18435	COG2985	domain, Protein
AL475_18445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL475_18465	COG1280	lysine exporter protein (LysE YggA)
AL475_18510	COG3122	Protein conserved in bacteria
AL475_18530	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL475_18530	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL475_18535	COG0509	glycine decarboxylation via glycine cleavage system
AL475_18550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL475_18560	COG3706	GGDEF domain
AL475_18565	COG5001	Diguanylate cyclase
AL475_18570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_18585	COG0546	phosphoglycolate phosphatase activity
AL475_18610	COG0484	heat shock protein binding
AL475_18620	COG1716	ATPase activity
AL475_18620	COG5001	Diguanylate cyclase
AL475_18625	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL475_18635	COG4181	ATPase activity
AL475_18640	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL475_18650	COG1984	allophanate hydrolase subunit 2
AL475_18660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL475_18665	COG5002	protein histidine kinase activity
AL475_18665	COG5001	Diguanylate cyclase
AL475_18665	COG3447	MASE1 domain protein
AL475_18670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL475_18675	COG0840	transmembrane signaling receptor activity
AL475_18680	COG0814	amino acid
AL475_18685	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL475_18690	COG0513	Belongs to the DEAD box helicase family
AL475_18695	COG1309	transcriptional regulator
AL475_18705	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL475_18720	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL475_18750	COG0840	transmembrane signaling receptor activity
AL475_18760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL475_18770	COG0463	Glycosyl transferase, family 2
AL475_18780	COG0583	DNA-binding transcription factor activity
AL475_18785	COG0697	spore germination
AL475_18790	COG2207	Transcriptional regulator
AL475_18790	COG1917	Cupin 2, conserved barrel domain protein
AL475_18815	COG0330	HflC and HflK could
AL475_18825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL475_18840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL475_18845	COG0583	DNA-binding transcription factor activity
AL475_18850	COG3781	membrane
AL475_18855	COG0243	molybdopterin cofactor binding
AL475_18860	COG1271	oxidase subunit
AL475_18865	COG1294	oxidase, subunit
AL475_18870	COG0800	Aldolase
AL475_18875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL475_18880	COG1904	glucuronate isomerase
AL475_18885	COG0246	Mannitol dehydrogenase
AL475_18900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL475_18910	COG2186	Transcriptional regulator
AL475_18920	COG2390	Transcriptional regulator
AL475_18930	COG1070	Carbohydrate kinase
AL475_18940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_18955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL475_18965	COG1120	ATPase activity
AL475_18970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL475_19005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_19030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL475_19035	COG2146	nitrite reductase [NAD(P)H] activity
AL475_19070	COG2814	Major facilitator Superfamily
AL475_19075	COG3118	belongs to the thioredoxin family
AL475_19080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL475_19095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL475_19105	COG1596	polysaccharide export
AL475_19130	COG0438	transferase activity, transferring glycosyl groups
AL475_19135	COG0438	transferase activity, transferring glycosyl groups
AL475_19135	COG0297	glycogen (starch) synthase activity
AL475_19150	COG0247	lactate metabolic process
AL475_19155	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AL475_19160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL475_19165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL475_19170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL475_19220	COG4386	tail sheath protein
AL475_19260	COG4695	Portal protein
AL475_19320	COG0110	maltose O-acetyltransferase activity
AL475_19430	COG3081	Nucleoid-associated protein
AL475_19455	COG4974	Belongs to the 'phage' integrase family
AL475_19475	COG2827	Endonuclease containing a URI domain
AL475_19485	COG1879	ABC-type sugar transport system periplasmic component
AL475_19490	COG5002	protein histidine kinase activity
AL475_19490	COG0784	Response regulator, receiver
AL475_19510	COG1492	cobalamin metabolic process
AL475_19515	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL475_19520	COG4149	molybdate abc transporter
AL475_19525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL475_19540	COG1289	transmembrane transporter activity
AL475_19580	COG0210	DNA helicase
AL475_19585	COG1335	isochorismatase
AL475_19590	COG1803	Methylglyoxal synthase
AL475_19595	COG1879	ABC-type sugar transport system periplasmic component
AL475_19600	COG2198	Histidine kinase
AL475_19600	COG2205	protein histidine kinase activity
AL475_19600	COG0784	Response regulator, receiver
AL475_19605	COG0469	pyruvate kinase activity
AL475_19610	COG2271	Major facilitator Superfamily
AL475_19615	COG1840	ABC-type Fe3 transport system, periplasmic component
AL475_19635	COG1979	alcohol dehydrogenase
AL475_19640	COG2207	Transcriptional regulator
AL475_19655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL475_19660	COG3706	GGDEF domain
AL475_19680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_19685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL475_19695	COG0183	Belongs to the thiolase family
AL475_19735	COG0243	molybdopterin cofactor binding
AL475_19750	COG3850	Histidine kinase
AL475_19755	COG2197	response regulator
AL475_19760	COG3069	C4-dicarboxylate transmembrane transporter activity
AL475_19775	COG2814	Major facilitator Superfamily
AL475_19780	COG0840	transmembrane signaling receptor activity
AL475_19785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_19805	COG0840	transmembrane signaling receptor activity
AL475_19810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL475_19825	COG2897	thiosulfate sulfurtransferase activity
AL475_19830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL475_19840	COG0302	gtp cyclohydrolase
AL475_19845	COG0531	amino acid
AL475_19855	COG4303	Ethanolamine ammonia lyase large subunit
AL475_19865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_19865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL475_19870	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL475_19875	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL475_19885	COG1011	Hydrolase
AL475_19890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL475_19910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL475_19920	COG3842	ATPase activity
AL475_19940	COG2866	Carboxypeptidase
AL475_19965	COG4166	transmembrane transport
AL475_19970	COG4174	ABC transporter (Permease)
AL475_19975	COG4239	(ABC) transporter, permease
AL475_19980	COG4172	Belongs to the ABC transporter superfamily
AL475_19985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL475_20000	COG2205	protein histidine kinase activity
AL475_20000	COG0784	Response regulator, receiver
AL475_20005	COG5001	Diguanylate cyclase
AL475_20005	COG4251	negative regulation of phosphorylation
AL475_20005	COG2203	Gaf domain
AL475_20005	COG3706	GGDEF domain
AL475_20015	COG3706	GGDEF domain
AL475_20025	COG2501	S4 domain
AL475_20065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_20090	COG2207	Transcriptional regulator
AL475_20110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL475_20120	COG0488	(ABC) transporter
AL475_20140	COG2814	Major facilitator Superfamily
AL475_20160	COG3710	Transcriptional regulator
AL475_20175	COG0384	phenazine biosynthesis protein PhzF
AL475_20200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_20215	COG2233	PERMEase
AL475_20235	COG1953	Uracil, thiamine, allantoin
AL475_20245	COG0765	amino acid transport
AL475_20250	COG0765	amino acid transport
AL475_20280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL475_20300	COG0402	S-adenosylhomocysteine deaminase activity
AL475_20305	COG2351	hydroxyisourate hydrolase activity
AL475_20345	COG1129	ABC transporter
AL475_20350	COG1309	transcriptional regulator
AL475_20360	COG3706	GGDEF domain
AL475_20370	COG0745	RESPONSE REGULATOR receiver
AL475_20370	COG3706	GGDEF domain
AL475_20385	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL475_20390	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL475_20400	COG0745	RESPONSE REGULATOR receiver
AL475_20420	COG0023	Translation Initiation Factor
AL475_20435	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL475_20445	COG0045	succinate-CoA ligase (ADP-forming) activity
AL475_20445	COG1042	CoA-binding domain protein
AL475_20445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL475_20450	COG0583	DNA-binding transcription factor activity
AL475_20455	COG4771	TonB-dependent receptor
AL475_20455	COG1629	transport
AL475_20475	COG2050	protein possibly involved in aromatic compounds catabolism
AL475_20480	COG0501	Belongs to the peptidase M48B family
AL475_20485	COG2824	Alkylphosphonate utilization operon protein PhnA
AL475_20495	COG0861	Integral membrane protein TerC family
AL475_20500	COG0737	Belongs to the 5'-nucleotidase family
AL475_20505	COG3593	DNA synthesis involved in DNA repair
AL475_20515	COG0583	DNA-binding transcription factor activity
AL475_20520	COG2116	formate transmembrane transporter activity
AL475_20525	COG2353	YceI-like domain
AL475_20530	COG3038	cytochrome b561
AL475_20555	COG5001	Diguanylate cyclase
AL475_20565	COG0243	molybdopterin cofactor binding
AL475_20570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL475_20575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL475_20575	COG1017	nitric oxide dioxygenase activity
AL475_20590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL475_20605	COG0247	lactate metabolic process
AL475_20605	COG2181	nitrate reductase activity
AL475_20610	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL475_20610	COG1902	pentaerythritol trinitrate reductase activity
AL475_20630	COG1760	l-serine dehydratase
AL475_20660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL475_20670	COG2205	protein histidine kinase activity
AL475_20670	COG5002	protein histidine kinase activity
AL475_20670	COG0784	Response regulator, receiver
AL475_20675	COG3437	response regulator, receiver
AL475_20685	COG2207	Transcriptional regulator
AL475_20690	COG0582	viral genome integration into host DNA
AL475_20700	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL475_20705	COG2200	EAL domain
AL475_20705	COG2199	diguanylate cyclase activity
AL475_20705	COG2202	Pas domain
AL475_20725	COG5001	Diguanylate cyclase
AL475_20725	COG4251	negative regulation of phosphorylation
AL475_20725	COG2203	Gaf domain
AL475_20725	COG3706	GGDEF domain
AL475_20775	COG2181	nitrate reductase activity
AL475_20780	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AL475_20785	COG1140	nitrate reductase beta subunit
AL475_20790	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL475_20795	COG2223	nitrite transmembrane transporter activity
AL475_20800	COG3850	Histidine kinase
AL475_20805	COG2197	response regulator
AL475_20810	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AL475_20815	COG2239	Acts as a magnesium transporter
AL475_20820	COG3290	protein histidine kinase activity
AL475_20820	COG0840	transmembrane signaling receptor activity
AL475_20870	COG1518	maintenance of DNA repeat elements
AL475_20885	COG2003	Belongs to the UPF0758 family
AL475_20920	COG0328	RNA-DNA hybrid ribonuclease activity
AL475_20960	COG3501	Rhs element vgr protein
AL475_20980	COG0523	cobalamin synthesis protein
AL475_20985	COG0038	chloride channel
AL475_20995	COG0156	8-amino-7-oxononanoate synthase activity
AL475_21000	COG0784	Response regulator, receiver
AL475_21000	COG2205	protein histidine kinase activity
AL475_21005	COG0419	ATPase involved in DNA repair
AL475_21015	COG1609	Transcriptional regulator
AL475_21020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_21020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_21025	COG1105	Belongs to the carbohydrate kinase PfkB family
AL475_21030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_21030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL475_21030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_21035	COG4067	protein conserved in archaea
AL475_21035	COG0189	ligase activity
AL475_21045	COG0602	queuosine metabolic process
AL475_21050	COG1328	CTP reductase activity
AL475_21105	COG2207	Transcriptional regulator
AL475_21115	COG1073	alpha beta
AL475_21120	COG1073	alpha beta
AL475_21130	COG1902	pentaerythritol trinitrate reductase activity
AL475_21135	COG4221	oxidoreductase activity
AL475_21150	COG1073	alpha beta
AL475_21175	COG1566	PFAM secretion protein HlyD family protein
AL475_21180	COG1309	transcriptional regulator
AL475_21200	COG1280	lysine exporter protein (LysE YggA)
AL475_21205	COG0745	RESPONSE REGULATOR receiver
AL475_21215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL475_21225	COG0583	DNA-binding transcription factor activity
AL475_21240	COG1309	transcriptional regulator
AL475_21245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL475_21275	COG1335	isochorismatase
AL475_21280	COG4977	sequence-specific DNA binding
AL475_21285	COG0456	acetyltransferase
AL475_21295	COG1280	lysine exporter protein (LysE YggA)
AL475_21300	COG0494	nUDIX hydrolase
AL475_21310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL475_21340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL475_21360	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_21370	COG0454	-acetyltransferase
AL475_21430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL475_21435	COG0789	Transcriptional regulator
AL475_21490	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_21500	COG4628	conserved protein (DUF2132)
AL475_21535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL475_21540	COG0513	Belongs to the DEAD box helicase family
AL475_21545	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL475_21555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL475_21565	COG0583	DNA-binding transcription factor activity
AL475_21580	COG3710	Transcriptional regulator
AL475_21585	COG4232	protein-disulfide reductase activity
AL475_21590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL475_21595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL475_21605	COG1252	NADH dehydrogenase
AL475_21615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_21620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_21630	COG2207	Transcriptional regulator
AL475_21635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_21635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL475_21635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_21645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL475_21680	COG1538	Outer membrane efflux protein
AL475_21690	COG1132	(ABC) transporter
AL475_21705	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL475_21715	COG1349	DNA-binding transcription factor activity
AL475_21720	COG0110	maltose O-acetyltransferase activity
AL475_21725	COG3706	GGDEF domain
AL475_21735	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL475_21760	COG0747	negative chemotaxis
AL475_21765	COG4172	Belongs to the ABC transporter superfamily
AL475_21775	COG3437	response regulator, receiver
AL475_21780	COG2205	protein histidine kinase activity
AL475_21780	COG2198	Histidine kinase
AL475_21780	COG0784	Response regulator, receiver
AL475_21790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL475_21815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_21830	COG2423	ornithine cyclodeaminase activity
AL475_21840	COG4145	pantothenate transmembrane transporter activity
AL475_21845	COG0583	DNA-binding transcription factor activity
AL475_21850	COG0435	Glutathione S-transferase
AL475_21855	COG0400	carboxylic ester hydrolase activity
AL475_21860	COG1280	lysine exporter protein (LysE YggA)
AL475_21875	COG1473	amidohydrolase
AL475_21895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_21900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL475_21905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL475_21915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL475_21930	COG2721	sulfolactate sulfo-lyase activity
AL475_21985	COG0625	glutathione transferase activity
AL475_22005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL475_22015	COG0573	inorganic phosphate transmembrane transporter activity
AL475_22020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL475_22030	COG2207	Transcriptional regulator
AL475_22040	COG1464	Belongs to the NlpA lipoprotein family
AL475_22045	COG0512	Glutamine amidotransferase of anthranilate synthase
AL475_22045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL475_22065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL475_22080	COG0653	protein targeting
AL475_22085	COG2814	Major facilitator Superfamily
AL475_22095	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_22105	COG1028	Short-chain dehydrogenase reductase Sdr
AL475_22115	COG1024	Enoyl-CoA hydratase
AL475_22120	COG1024	Enoyl-CoA hydratase
AL475_22125	COG1960	acyl-CoA dehydrogenase activity
AL475_22135	COG0183	Belongs to the thiolase family
AL475_22145	COG1960	acyl-CoA dehydrogenase activity
AL475_22150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL475_22155	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL475_22170	COG0450	alkyl hydroperoxide reductase
AL475_22175	COG3634	alkyl hydroperoxide reductase activity
AL475_22205	COG1609	Transcriptional regulator
AL475_22205	COG2207	Transcriptional regulator
AL475_22210	COG1454	alcohol dehydrogenase
AL475_22215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_22285	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL475_22300	COG1609	Transcriptional regulator
AL475_22300	COG2207	Transcriptional regulator
AL475_22305	COG4604	ABC transporter, ATP-binding protein
AL475_22310	COG4605	iron ion homeostasis
AL475_22315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL475_22335	COG3291	Pkd domain containing protein
AL475_22335	COG4412	M6 family metalloprotease domain protein
AL475_22340	COG5380	lipid catabolic process
AL475_22345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL475_22355	COG1522	sequence-specific DNA binding
AL475_22375	COG2814	Major facilitator Superfamily
AL475_22385	COG0840	transmembrane signaling receptor activity
AL475_22405	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL475_22410	COG3279	Response regulator of the LytR AlgR family
AL475_22415	COG3275	phosphorelay sensor kinase activity
AL475_22420	COG4989	oxidoreductase activity
AL475_22435	COG0366	Alpha amylase catalytic
AL475_22440	COG3227	Zinc metalloprotease (Elastase)
AL475_22445	COG3047	cAMP biosynthetic process
AL475_22450	COG0071	Belongs to the small heat shock protein (HSP20) family
AL475_22460	COG0251	oxidation-reduction process
AL475_22470	COG1403	HNH endonuclease
AL475_22480	COG1132	(ABC) transporter
AL475_22485	COG1132	(ABC) transporter
AL475_22495	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL475_22500	COG2246	polysaccharide biosynthetic process
AL475_22510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL475_22520	COG0242	peptide deformylase activity
AL475_22530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL475_22535	COG2084	Dehydrogenase
AL475_22545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL475_22550	COG0583	DNA-binding transcription factor activity
AL475_22595	COG1063	alcohol dehydrogenase
AL475_22600	COG0156	8-amino-7-oxononanoate synthase activity
AL475_22605	COG1012	belongs to the aldehyde dehydrogenase family
AL475_22610	COG3284	Transcriptional regulator
AL475_22620	COG0346	lactoylglutathione lyase activity
AL475_22640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL475_22650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL475_22655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL475_22660	COG0363	glucosamine-6-phosphate deaminase activity
AL475_22665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL475_22680	COG0583	DNA-binding transcription factor activity
AL475_22695	COG1410	methionine synthase
AL475_22695	COG0646	methionine synthase
AL475_22700	COG0531	amino acid
AL475_22715	COG1473	amidohydrolase
AL475_22720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL475_22725	COG1929	Belongs to the glycerate kinase type-1 family
AL475_22730	COG2610	gluconate transmembrane transporter activity
AL475_22735	COG3835	regulator
AL475_22740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_22745	COG4533	DNA binding
AL475_22760	COG0840	transmembrane signaling receptor activity
AL475_22785	COG0251	oxidation-reduction process
AL475_22820	COG4964	Belongs to the GSP D family
AL475_22860	COG0798	PFAM Bile acid sodium symporter
AL475_22885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL475_22890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL475_22890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL475_22900	COG0745	RESPONSE REGULATOR receiver
AL475_22920	COG3036	rescue of stalled ribosome
AL475_22925	COG1278	Cold shock
AL475_22930	COG4681	YaeQ
AL475_22935	COG3706	GGDEF domain
AL475_22940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL475_22940	COG1017	nitric oxide dioxygenase activity