locus-tag	class	description
MKS89_00010	COG0592	DNA-directed DNA polymerase activity
MKS89_00020	COG0187	DNA topoisomerase II activity
MKS89_00025	COG0071	Belongs to the small heat shock protein (HSP20) family
MKS89_00035	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MKS89_00045	COG3977	Valine--pyruvate aminotransferase
MKS89_00055	COG0439	Biotin carboxylase
MKS89_00085	COG0751	glycine-tRNA ligase activity
MKS89_00090	COG0752	glycyl-tRNA synthetase alpha subunit
MKS89_00100	COG2119	membrane
MKS89_00120	COG0425	Belongs to the sulfur carrier protein TusA family
MKS89_00135	COG0129	dihydroxy-acid dehydratase activity
MKS89_00140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MKS89_00145	COG3978	acetolactate synthase activity
MKS89_00155	COG0606	chelatase, subunit chli
MKS89_00160	COG0204	Acyl-transferase
MKS89_00165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKS89_00170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MKS89_00180	COG3084	Protein conserved in bacteria
MKS89_00185	COG4326	sporulation control protein
MKS89_00190	COG1272	protein, Hemolysin III
MKS89_00195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKS89_00200	COG0569	domain protein
MKS89_00205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MKS89_00205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKS89_00210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MKS89_00220	COG0758	DNA mediated transformation
MKS89_00225	COG2922	Belongs to the Smg family
MKS89_00230	COG0551	DNA topoisomerase type I activity
MKS89_00235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MKS89_00240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MKS89_00245	COG0009	L-threonylcarbamoyladenylate synthase
MKS89_00250	COG0408	coproporphyrinogen oxidase activity
MKS89_00265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MKS89_00305	COG0583	DNA-binding transcription factor activity
MKS89_00310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MKS89_00315	COG2960	long-chain fatty acid transporting porin activity
MKS89_00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKS89_00325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKS89_00365	COG0747	negative chemotaxis
MKS89_00370	COG0601	transmembrane transport
MKS89_00375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKS89_00385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKS89_00390	COG1172	Belongs to the binding-protein-dependent transport system permease family
MKS89_00395	COG1172	Belongs to the binding-protein-dependent transport system permease family
MKS89_00400	COG1129	ABC transporter
MKS89_00405	COG1879	ABC-type sugar transport system periplasmic component
MKS89_00410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKS89_00415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MKS89_00435	COG0210	DNA helicase
MKS89_00440	COG3097	Belongs to the UPF0267 family
MKS89_00450	COG0405	Gamma-glutamyltransferase
MKS89_00455	COG1280	lysine exporter protein (LysE YggA)
MKS89_00460	COG2962	Rard protein
MKS89_00465	COG0514	ATP-dependent DNA helicase (RecQ)
MKS89_00485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKS89_00490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKS89_00495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKS89_00500	COG2723	6-phospho-beta-galactosidase activity
MKS89_00505	COG1447	Phosphotransferase system cellobiose-specific component IIA
MKS89_00510	COG1609	Transcriptional regulator
MKS89_00520	COG1929	Belongs to the glycerate kinase type-1 family
MKS89_00525	COG1486	melibiose metabolic process
MKS89_00530	COG1263	PTS System
MKS89_00530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_00535	COG2188	Transcriptional regulator
MKS89_00600	COG1561	YicC-like family, N-terminal region
MKS89_00605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MKS89_00610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MKS89_00615	COG1560	Kdo2-lipid A biosynthetic process
MKS89_00620	COG1560	Kdo2-lipid A biosynthetic process
MKS89_00625	COG1309	transcriptional regulator
MKS89_00630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MKS89_00640	COG2003	Belongs to the UPF0758 family
MKS89_00645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MKS89_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MKS89_00665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MKS89_00670	COG0859	PFAM glycosyl transferase family 9
MKS89_00675	COG0463	Glycosyl transferase, family 2
MKS89_00680	COG0859	PFAM glycosyl transferase family 9
MKS89_00685	COG3642	lipopolysaccharide core region biosynthetic process
MKS89_00695	COG1519	Transferase
MKS89_00715	COG0859	PFAM glycosyl transferase family 9
MKS89_00725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MKS89_00730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKS89_00750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKS89_00760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKS89_00830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKS89_00860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKS89_00870	COG3068	Protein conserved in bacteria
MKS89_00875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKS89_00880	COG1573	uracil-dna glycosylase
MKS89_00885	COG0776	regulation of translation
MKS89_00900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKS89_00915	COG2814	Major facilitator Superfamily
MKS89_00920	COG1566	PFAM secretion protein HlyD family protein
MKS89_00935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MKS89_00940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKS89_00945	COG1758	RNA polymerase activity
MKS89_00950	COG0194	GDP metabolic process
MKS89_00960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MKS89_00965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKS89_00985	COG1027	Aspartate ammonia-lyase
MKS89_00990	COG3447	MASE1 domain protein
MKS89_00990	COG5001	Diguanylate cyclase
MKS89_00990	COG5002	protein histidine kinase activity
MKS89_00995	COG3030	protein affecting phage T7 exclusion by the F plasmid
MKS89_01000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MKS89_01005	COG2205	protein histidine kinase activity
MKS89_01010	COG0745	RESPONSE REGULATOR receiver
MKS89_01020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MKS89_01030	COG0205	6-phosphofructokinase activity
MKS89_01035	COG1494	fructose-1,6-bisphosphatase
MKS89_01040	COG3074	FtsZ-dependent cytokinesis
MKS89_01045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MKS89_01050	COG0460	homoserine dehydrogenase
MKS89_01050	COG0527	aspartate kinase activity
MKS89_01055	COG0626	cystathionine gamma-synthase activity
MKS89_01060	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
MKS89_01070	COG0281	malic enzyme
MKS89_01075	COG0254	rRNA binding
MKS89_01080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKS89_01085	COG1609	Transcriptional regulator
MKS89_01095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MKS89_01100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MKS89_01105	COG1575	Belongs to the MenA family. Type 1 subfamily
MKS89_01115	COG0534	Mate efflux family protein
MKS89_01145	COG0459	protein refolding
MKS89_01150	COG1119	ATPase activity
MKS89_01155	COG1509	lysine 2,3-aminomutase activity
MKS89_01170	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MKS89_01175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MKS89_01180	COG1053	succinate dehydrogenase
MKS89_01185	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MKS89_01190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKS89_01195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MKS89_01200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MKS89_01205	COG1045	serine acetyltransferase
MKS89_01210	COG1695	Transcriptional regulator
MKS89_01215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MKS89_01220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MKS89_01225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MKS89_01230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MKS89_01235	COG0137	argininosuccinate synthase activity
MKS89_01250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MKS89_01250	COG0678	peroxiredoxin activity
MKS89_01260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MKS89_01285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MKS89_01290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MKS89_01300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MKS89_01305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MKS89_01315	COG0180	Tryptophanyl-tRNA synthetase
MKS89_01320	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKS89_01330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MKS89_01345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MKS89_01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MKS89_01400	COG3954	Phosphoribulokinase
MKS89_01410	COG0429	hydrolase of the alpha beta-hydrolase fold
MKS89_01420	COG0488	(ABC) transporter
MKS89_01425	COG2249	NAD(P)H dehydrogenase (quinone) activity
MKS89_01440	COG1047	Peptidyl-prolyl cis-trans
MKS89_01445	COG1446	asparaginase
MKS89_01450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKS89_01455	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MKS89_01460	COG0557	exoribonuclease II activity
MKS89_01465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKS89_01470	COG0051	transcription antitermination factor activity, RNA binding
MKS89_01475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MKS89_01480	COG0088	Forms part of the polypeptide exit tunnel
MKS89_01490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MKS89_01495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MKS89_01500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MKS89_01505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MKS89_01510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MKS89_01520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MKS89_01525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MKS89_01530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MKS89_01535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MKS89_01540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MKS89_01545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MKS89_01550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MKS89_01555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MKS89_01565	COG1841	ribosomal large subunit assembly
MKS89_01570	COG0200	Binds to the 23S rRNA
MKS89_01575	COG0201	protein transport
MKS89_01580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MKS89_01585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MKS89_01590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MKS89_01600	COG0202	RNA polymerase activity
MKS89_01605	COG0203	ribosomal protein L17
MKS89_01615	COG0545	Peptidyl-prolyl cis-trans isomerase
MKS89_01625	COG2153	protein acetylation
MKS89_01635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MKS89_01635	COG1648	precorrin-2 dehydrogenase activity
MKS89_01640	COG0175	sulfate reduction
MKS89_01645	COG2895	sulfate adenylyltransferase (ATP) activity
MKS89_01650	COG0471	metal ion transport
MKS89_01650	COG0490	domain, Protein
MKS89_01655	COG0529	Catalyzes the synthesis of activated sulfate
MKS89_01690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKS89_01695	COG0729	surface antigen
MKS89_01700	COG2911	Protein conserved in bacteria
MKS89_01705	COG2105	PFAM AIG2 family protein
MKS89_01710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MKS89_01720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MKS89_01725	COG0163	prenyltransferase activity
MKS89_01730	COG4143	(ABC) transporter
MKS89_01735	COG1178	ABC-type Fe3 transport system permease component
MKS89_01740	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MKS89_01745	COG3028	Belongs to the UPF0307 family
MKS89_01750	COG0312	modulator of DNA gyrase
MKS89_01775	COG2239	Acts as a magnesium transporter
MKS89_01780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_01785	COG1660	Displays ATPase and GTPase activities
MKS89_01790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_01795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MKS89_01805	COG1137	ATPase activity
MKS89_01820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MKS89_01825	COG0517	IMP dehydrogenase activity
MKS89_01825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MKS89_01835	COG1127	ABC transporter
MKS89_01840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MKS89_01845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MKS89_01850	COG2854	intermembrane phospholipid transfer
MKS89_01860	COG5007	Belongs to the BolA IbaG family
MKS89_01865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MKS89_01870	COG0204	Acyl-transferase
MKS89_01875	COG0251	oxidation-reduction process
MKS89_01880	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MKS89_01890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MKS89_01910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MKS89_01930	COG0564	pseudouridine synthase activity
MKS89_01935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKS89_01940	COG4269	membrane
MKS89_01945	COG0501	Belongs to the peptidase M48B family
MKS89_01950	COG0525	valine-tRNA ligase activity
MKS89_01955	COG2927	DNA polymerase III (CHI subunit)
MKS89_01960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MKS89_01965	COG0795	lipopolysaccharide-transporting ATPase activity
MKS89_01970	COG0795	lipopolysaccharide-transporting ATPase activity
MKS89_01990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKS89_02050	COG0066	3-isopropylmalate dehydratase activity
MKS89_02055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MKS89_02060	COG0473	3-isopropylmalate dehydrogenase activity
MKS89_02065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKS89_02080	COG0583	DNA-binding transcription factor activity
MKS89_02085	COG0028	Belongs to the TPP enzyme family
MKS89_02095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKS89_02100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKS89_02105	COG1012	belongs to the aldehyde dehydrogenase family
MKS89_02110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKS89_02120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKS89_02125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKS89_02130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MKS89_02135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MKS89_02145	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MKS89_02155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKS89_02160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKS89_02180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MKS89_02190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MKS89_02225	COG0571	ribonuclease III activity
MKS89_02230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MKS89_02235	COG1381	Involved in DNA repair and RecF pathway recombination
MKS89_02240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MKS89_02245	COG0736	holo-[acyl-carrier-protein] synthase activity
MKS89_02250	COG4999	Histidine kinase
MKS89_02250	COG2205	protein histidine kinase activity
MKS89_02250	COG3437	response regulator, receiver
MKS89_02250	COG3850	Histidine kinase
MKS89_02260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKS89_02265	COG3956	TIGRFAM MazG family protein
MKS89_02270	COG0504	CTP synthase activity
MKS89_02280	COG0617	tRNA 3'-terminal CCA addition
MKS89_02285	COG4991	sh3 domain protein
MKS89_02290	COG0306	phosphate transporter
MKS89_02295	COG1392	Phosphate transport regulator
MKS89_02300	COG3025	triphosphatase activity
MKS89_02310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MKS89_02315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MKS89_02315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MKS89_02320	COG1538	Outer membrane efflux protein
MKS89_02325	COG0494	nUDIX hydrolase
MKS89_02330	COG3151	Protein conserved in bacteria
MKS89_02340	COG3150	esterase
MKS89_02350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MKS89_02365	COG3220	belongs to the UPF0276 family
MKS89_02380	COG1595	DNA-templated transcription, initiation
MKS89_02385	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MKS89_02390	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MKS89_02395	COG0237	dephospho-CoA kinase activity
MKS89_02405	COG1459	type II secretion system
MKS89_02410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKS89_02430	COG0157	Belongs to the NadC ModD family
MKS89_02440	COG0716	FMN binding
MKS89_02445	COG4974	Belongs to the 'phage' integrase family
MKS89_02450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKS89_02455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MKS89_02490	COG0477	Major facilitator Superfamily
MKS89_02505	COG0667	Aldo Keto reductase
MKS89_02520	COG2186	Transcriptional regulator
MKS89_02525	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MKS89_02530	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKS89_02535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKS89_02550	COG0288	reversible hydration of carbon dioxide
MKS89_02555	COG1131	(ABC) transporter
MKS89_02560	COG0842	Transport permease protein
MKS89_02570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKS89_02575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKS89_02580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKS89_02595	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MKS89_02600	COG1414	Transcriptional regulator
MKS89_02605	COG3623	hexulose-6-phosphate isomerase
MKS89_02610	COG1129	ABC transporter
MKS89_02615	COG1172	Belongs to the binding-protein-dependent transport system permease family
MKS89_02640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MKS89_02645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MKS89_02650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKS89_02660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKS89_02665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MKS89_02670	COG1489	DNA binding
MKS89_02675	COG1643	Atp-dependent helicase
MKS89_02680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKS89_02695	COG3112	Uncharacterised protein family (UPF0231)
MKS89_02705	COG0004	ammonium transporteR
MKS89_02715	COG0628	permease
MKS89_02720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MKS89_02725	COG0316	Belongs to the HesB IscA family
MKS89_02730	COG0739	heme binding
MKS89_02735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKS89_02740	COG2027	D-alanyl-D-alanine carboxypeptidase
MKS89_02745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKS89_02750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKS89_02755	COG1534	Rna-binding protein
MKS89_02760	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MKS89_02765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKS89_02770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MKS89_02775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKS89_02780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKS89_02795	COG0779	Required for maturation of 30S ribosomal subunits
MKS89_02800	COG0195	Participates in both transcription termination and antitermination
MKS89_02815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MKS89_02820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MKS89_02825	COG1185	polyribonucleotide nucleotidyltransferase activity
MKS89_02835	COG0534	Mate efflux family protein
MKS89_02840	COG0826	peptidase U32
MKS89_02845	COG0826	peptidase U32
MKS89_02855	COG3154	lipid carrier protein
MKS89_02860	COG3153	acetyltransferase
MKS89_02870	COG0456	acetyltransferase
MKS89_02875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKS89_02910	COG1216	Glycosyl transferase, family 2
MKS89_02910	COG1442	glycosyl transferase family 8
MKS89_02915	COG0438	transferase activity, transferring glycosyl groups
MKS89_02920	COG1045	serine acetyltransferase
MKS89_02925	COG0438	transferase activity, transferring glycosyl groups
MKS89_02950	COG0726	polysaccharide deacetylase
MKS89_02965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKS89_02970	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKS89_02985	COG0745	RESPONSE REGULATOR receiver
MKS89_03000	COG0513	Belongs to the DEAD box helicase family
MKS89_03005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MKS89_03020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MKS89_03025	COG2204	response regulator
MKS89_03035	COG0667	Aldo Keto reductase
MKS89_03040	COG3066	DNA modification
MKS89_03045	COG0494	nUDIX hydrolase
MKS89_03055	COG0730	response to heat
MKS89_03060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MKS89_03065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MKS89_03070	COG0583	DNA-binding transcription factor activity
MKS89_03075	COG0640	Transcriptional regulator
MKS89_03080	COG0268	Binds directly to 16S ribosomal RNA
MKS89_03085	COG0728	peptidoglycan biosynthetic process
MKS89_03090	COG0196	riboflavin kinase activity
MKS89_03100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MKS89_03105	COG1047	Peptidyl-prolyl cis-trans
MKS89_03110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MKS89_03115	COG1966	Carbon starvation protein
MKS89_03125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MKS89_03130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MKS89_03140	COG3279	Response regulator of the LytR AlgR family
MKS89_03145	COG3275	phosphorelay sensor kinase activity
MKS89_03150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKS89_03155	COG0287	Prephenate dehydrogenase
MKS89_03155	COG1605	Chorismate mutase
MKS89_03165	COG0488	(ABC) transporter
MKS89_03170	COG0741	lytic transglycosylase activity
MKS89_03175	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
MKS89_03185	COG3718	enzyme involved in inositol metabolism
MKS89_03200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MKS89_03205	COG1605	Chorismate mutase
MKS89_03205	COG0077	Prephenate dehydratase
MKS89_03210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MKS89_03215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKS89_03220	COG0564	pseudouridine synthase activity
MKS89_03230	COG0542	response to heat
MKS89_03300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKS89_03305	COG0826	peptidase U32
MKS89_03310	COG2974	May be involved in recombination
MKS89_03315	COG0745	RESPONSE REGULATOR receiver
MKS89_03320	COG5002	protein histidine kinase activity
MKS89_03330	COG0248	Ppx GppA phosphatase
MKS89_03335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MKS89_03345	COG0581	inorganic phosphate transmembrane transporter activity
MKS89_03350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MKS89_03355	COG0704	Plays a role in the regulation of phosphate uptake
MKS89_03360	COG0450	alkyl hydroperoxide reductase
MKS89_03365	COG0583	DNA-binding transcription factor activity
MKS89_03370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MKS89_03380	COG0516	GMP reductase activity
MKS89_03380	COG0517	IMP dehydrogenase activity
MKS89_03395	COG1862	Preprotein translocase
MKS89_03400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKS89_03405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKS89_03410	COG0483	inositol monophosphate 1-phosphatase activity
MKS89_03415	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MKS89_03420	COG1959	2 iron, 2 sulfur cluster binding
MKS89_03425	COG1104	cysteine desulfurase activity
MKS89_03430	COG0822	iron-sulfur transferase activity
MKS89_03435	COG0316	Belongs to the HesB IscA family
MKS89_03445	COG0443	Heat shock 70 kDa protein
MKS89_03450	COG0633	Ferredoxin
MKS89_03455	COG2975	iron-sulfur cluster assembly
MKS89_03465	COG0105	UTP biosynthetic process
MKS89_03470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MKS89_03480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MKS89_03485	COG0124	histidyl-tRNA synthetase
MKS89_03490	COG2976	Protein conserved in bacteria
MKS89_03495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKS89_03500	COG1160	GTP binding
MKS89_03515	COG0516	GMP reductase activity
MKS89_03515	COG0517	IMP dehydrogenase activity
MKS89_03555	COG2169	Transcriptional regulator
MKS89_03555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKS89_03565	COG2755	lipolytic protein G-D-S-L family
MKS89_03565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MKS89_03605	COG0583	DNA-binding transcription factor activity
MKS89_03610	COG1349	DNA-binding transcription factor activity
MKS89_03620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_03625	COG0738	Major facilitator superfamily
MKS89_03650	COG0583	DNA-binding transcription factor activity
MKS89_03660	COG0454	-acetyltransferase
MKS89_03670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKS89_03675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKS89_03685	COG5002	protein histidine kinase activity
MKS89_03690	COG1115	amino acid carrier protein
MKS89_03705	COG3623	hexulose-6-phosphate isomerase
MKS89_03710	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MKS89_03715	COG0561	phosphatase activity
MKS89_03750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_03760	COG2207	Transcriptional regulator
MKS89_03770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_03770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_03770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_03835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MKS89_03890	COG2192	nodulation
MKS89_03910	COG2832	Protein of unknown function (DUF454)
MKS89_03915	COG2501	S4 domain
MKS89_03920	COG0840	transmembrane signaling receptor activity
MKS89_03925	COG3711	transcriptional antiterminator
MKS89_03930	COG2190	(PTS) system
MKS89_03930	COG1263	PTS System
MKS89_03930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_03935	COG0641	radical SAM
MKS89_04015	COG3976	FMN-binding domain protein
MKS89_04015	COG1053	succinate dehydrogenase
MKS89_04015	COG0431	NADPH-dependent FMN reductase
MKS89_04020	COG1053	succinate dehydrogenase
MKS89_04020	COG3976	FMN-binding domain protein
MKS89_04020	COG0431	NADPH-dependent FMN reductase
MKS89_04025	COG0583	DNA-binding transcription factor activity
MKS89_04035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MKS89_04045	COG0477	Major facilitator Superfamily
MKS89_04120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MKS89_04125	COG2867	negative regulation of translational initiation
MKS89_04130	COG2914	Belongs to the UPF0125 (RnfH) family
MKS89_04135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKS89_04145	COG0497	DNA recombination
MKS89_04150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MKS89_04155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MKS89_04165	COG2358	TRAP transporter, solute receptor (TAXI family
MKS89_04170	COG0443	Heat shock 70 kDa protein
MKS89_04175	COG0484	heat shock protein binding
MKS89_04210	COG0583	DNA-binding transcription factor activity
MKS89_04220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MKS89_04230	COG0686	Belongs to the AlaDH PNT family
MKS89_04240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MKS89_04265	COG0442	prolyl-tRNA aminoacylation
MKS89_04270	COG1720	tRNA m6t6A37 methyltransferase activity
MKS89_04275	COG1671	Belongs to the UPF0178 family
MKS89_04300	COG3098	single-species biofilm formation
MKS89_04305	COG0564	pseudouridine synthase activity
MKS89_04310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MKS89_04315	COG0142	geranyltranstransferase activity
MKS89_04325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MKS89_04335	COG4989	oxidoreductase activity
MKS89_04340	COG0301	tRNA thio-modification
MKS89_04340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKS89_04345	COG0583	DNA-binding transcription factor activity
MKS89_04360	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
MKS89_04365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKS89_04370	COG1611	Belongs to the LOG family
MKS89_04385	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MKS89_04385	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MKS89_04395	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
MKS89_04400	COG1464	Belongs to the NlpA lipoprotein family
MKS89_04405	COG2011	ABC-type metal ion transport system permease component
MKS89_04410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MKS89_04415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MKS89_04425	COG1263	PTS System
MKS89_04425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_04430	COG0366	Alpha amylase catalytic
MKS89_04445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MKS89_04450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MKS89_04460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MKS89_04480	COG1686	Belongs to the peptidase S11 family
MKS89_04485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MKS89_04490	COG0772	Belongs to the SEDS family
MKS89_04495	COG0768	penicillin binding
MKS89_04500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MKS89_04505	COG0799	negative regulation of ribosome biogenesis
MKS89_04510	COG1466	dna polymerase III delta subunit
MKS89_04515	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MKS89_04530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MKS89_04535	COG4535	Mg2 and Co2 transporter CorC
MKS89_04540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MKS89_04545	COG1702	phosphate starvation-inducible protein PhoH
MKS89_04555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKS89_04560	COG2190	(PTS) system
MKS89_04565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKS89_04570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_04575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKS89_04580	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MKS89_04590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MKS89_04595	COG0789	Transcriptional regulator
MKS89_04600	COG3118	belongs to the thioredoxin family
MKS89_04605	COG0300	oxidoreductase activity
MKS89_04610	COG1090	epimerase
MKS89_04645	COG3710	Transcriptional regulator
MKS89_04650	COG0326	Molecular chaperone. Has ATPase activity
MKS89_04655	COG0563	adenylate kinase activity
MKS89_04660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MKS89_04670	COG0367	asparagine synthase
MKS89_04675	COG1846	Transcriptional regulator
MKS89_04675	COG1940	carbohydrate kinase activity
MKS89_04690	COG0101	tRNA pseudouridine synthase activity
MKS89_04695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MKS89_04700	COG0285	dihydrofolate synthase activity
MKS89_04705	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MKS89_04710	COG1286	toxin biosynthetic process
MKS89_04715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MKS89_04720	COG2056	Na+-H+ antiporter family
MKS89_04725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MKS89_04735	COG0346	lactoylglutathione lyase activity
MKS89_04740	COG2186	Transcriptional regulator
MKS89_04745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKS89_04750	COG4660	Part of a membrane complex involved in electron transport
MKS89_04760	COG4658	electron transport chain
MKS89_04765	COG4656	Part of a membrane complex involved in electron transport
MKS89_04770	COG2878	Part of a membrane complex involved in electron transport
MKS89_04775	COG4657	Part of a membrane complex involved in electron transport
MKS89_04780	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_04790	COG3527	Alpha-acetolactate decarboxylase
MKS89_04800	COG1335	isochorismatase
MKS89_04805	COG1982	Orn Lys Arg decarboxylase major
MKS89_04810	COG0697	spore germination
MKS89_04830	COG0556	nucleotide-excision repair
MKS89_04835	COG2204	response regulator
MKS89_04840	COG2198	Histidine kinase
MKS89_04845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MKS89_04850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MKS89_04855	COG0521	Mo-molybdopterin cofactor biosynthetic process
MKS89_04860	COG0315	cyclic pyranopterin monophosphate synthase activity
MKS89_04865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MKS89_04870	COG0314	molybdopterin synthase activity
MKS89_04890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKS89_04890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKS89_04895	COG0489	protein tyrosine kinase activity
MKS89_04900	COG0572	uridine kinase
MKS89_04915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKS89_04920	COG2067	long-chain fatty acid transport protein
MKS89_04925	COG0183	Belongs to the thiolase family
MKS89_04930	COG1024	Enoyl-CoA hydratase
MKS89_04930	COG1250	3-hydroxyacyl-CoA dehydrogenase
MKS89_04935	COG0778	Nitroreductase
MKS89_04940	COG0583	DNA-binding transcription factor activity
MKS89_04945	COG0745	RESPONSE REGULATOR receiver
MKS89_04950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MKS89_04955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKS89_04965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MKS89_04975	COG2983	Belongs to the UPF0260 family
MKS89_05000	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_05015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MKS89_05050	COG2986	histidine ammonia-lyase
MKS89_05055	COG1228	amidohydrolase
MKS89_05065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MKS89_05070	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MKS89_05100	COG4166	transmembrane transport
MKS89_05105	COG0601	transmembrane transport
MKS89_05115	COG4172	Belongs to the ABC transporter superfamily
MKS89_05120	COG0436	Aminotransferase
MKS89_05125	COG1169	isochorismate synthase
MKS89_05130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MKS89_05140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MKS89_05160	COG2855	membrane
MKS89_05180	COG1335	isochorismatase
MKS89_05190	COG1522	sequence-specific DNA binding
MKS89_05195	COG1946	Acyl-CoA thioesterase
MKS89_05225	COG0653	protein targeting
MKS89_05245	COG0483	inositol monophosphate 1-phosphatase activity
MKS89_05260	COG3842	ATPase activity
MKS89_05275	COG3639	organic phosphonate transmembrane transporter activity
MKS89_05290	COG3593	DNA synthesis involved in DNA repair
MKS89_05295	COG0210	DNA helicase
MKS89_05300	COG3842	ATPase activity
MKS89_05320	COG0395	ABC-type sugar transport system, permease component
MKS89_05325	COG1175	transmembrane transport
MKS89_05330	COG0583	DNA-binding transcription factor activity
MKS89_05340	COG0513	Belongs to the DEAD box helicase family
MKS89_05345	COG4628	conserved protein (DUF2132)
MKS89_05415	COG1917	Cupin 2, conserved barrel domain protein
MKS89_05415	COG2207	Transcriptional regulator
MKS89_05420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKS89_05430	COG1294	oxidase, subunit
MKS89_05435	COG1271	oxidase subunit
MKS89_05440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKS89_05450	COG5297	Belongs to the glycosyl hydrolase family 6
MKS89_05465	COG2207	Transcriptional regulator
MKS89_05465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKS89_05475	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MKS89_05480	COG2267	carboxylic ester hydrolase activity
MKS89_05490	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_05500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKS89_05505	COG5002	protein histidine kinase activity
MKS89_05535	COG4145	pantothenate transmembrane transporter activity
MKS89_05545	COG1349	DNA-binding transcription factor activity
MKS89_05550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKS89_05555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MKS89_05560	COG1882	Formate acetyltransferase
MKS89_05565	COG1879	ABC-type sugar transport system periplasmic component
MKS89_05580	COG0840	transmembrane signaling receptor activity
MKS89_05590	COG2226	methyltransferase
MKS89_05595	COG0676	glucose-6-phosphate 1-epimerase activity
MKS89_05600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MKS89_05605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKS89_05615	COG3139	Protein of unknown function (DUF1315)
MKS89_05620	COG0252	asparaginase activity
MKS89_05625	COG0616	signal peptide processing
MKS89_05630	COG0788	formyltetrahydrofolate deformylase activity
MKS89_05640	COG1199	ATP-dependent helicase activity
MKS89_05645	COG1214	PFAM Peptidase M22, glycoprotease
MKS89_05660	COG0596	Alpha beta hydrolase
MKS89_05665	COG0318	PFAM AMP-dependent synthetase and ligase
MKS89_05670	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MKS89_05675	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MKS89_05680	COG2894	cell division
MKS89_05690	COG3100	YcgL domain-containing protein
MKS89_05695	COG2951	lytic endotransglycosylase activity
MKS89_05700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MKS89_05745	COG2373	Large extracellular alpha-helical protein
MKS89_05750	COG4953	penicillin-binding protein 1C
MKS89_05755	COG4628	conserved protein (DUF2132)
MKS89_05765	COG0662	Cupin 2, conserved barrel domain protein
MKS89_05800	COG2169	Transcriptional regulator
MKS89_05800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKS89_05830	COG1940	carbohydrate kinase activity
MKS89_05830	COG1846	Transcriptional regulator
MKS89_05835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MKS89_05840	COG0363	glucosamine-6-phosphate deaminase activity
MKS89_05845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_05845	COG2190	(PTS) system
MKS89_05845	COG1263	PTS System
MKS89_05850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MKS89_05855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKS89_05860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKS89_05865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKS89_05875	COG0740	serine-type endopeptidase activity
MKS89_05885	COG4191	Histidine kinase
MKS89_05895	COG0740	serine-type endopeptidase activity
MKS89_05905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MKS89_05910	COG0776	regulation of translation
MKS89_05915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKS89_05920	COG1555	photosystem II stabilization
MKS89_05940	COG0539	negative regulation of cytoplasmic translation
MKS89_05945	COG0776	regulation of translation
MKS89_05950	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
MKS89_05955	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MKS89_05960	COG0284	orotidine-5'-phosphate decarboxylase activity
MKS89_05965	COG3385	transposase activity
MKS89_05990	COG1522	sequence-specific DNA binding
MKS89_05995	COG1674	ftsk spoiiie
MKS89_06000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MKS89_06005	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MKS89_06010	COG2186	Transcriptional regulator
MKS89_06020	COG0537	adenosine 5'-monophosphoramidase activity
MKS89_06045	COG3150	esterase
MKS89_06050	COG1252	NADH dehydrogenase
MKS89_06055	COG0601	transmembrane transport
MKS89_06060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKS89_06100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MKS89_06110	COG4591	ABC-type transport system involved in lipoprotein release permease component
MKS89_06115	COG1136	(ABC) transporter
MKS89_06120	COG4591	ABC-type transport system involved in lipoprotein release permease component
MKS89_06130	COG0658	competence protein
MKS89_06130	COG2333	competence protein COMEC
MKS89_06135	COG1132	(ABC) transporter
MKS89_06140	COG1663	tetraacyldisaccharide 4'-kinase activity
MKS89_06150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MKS89_06155	COG2719	SpoVR family
MKS89_06165	COG2766	serine protein kinase
MKS89_06175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MKS89_06190	COG1882	Formate acetyltransferase
MKS89_06205	COG3923	Primosomal replication protein n
MKS89_06210	COG0730	response to heat
MKS89_06215	COG1199	ATP-dependent helicase activity
MKS89_06220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKS89_06225	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKS89_06230	COG3012	SEC-C Motif Domain Protein
MKS89_06235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKS89_06240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MKS89_06245	COG0215	cysteine-tRNA ligase activity
MKS89_06250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MKS89_06255	COG0632	four-way junction helicase activity
MKS89_06265	COG1271	oxidase subunit
MKS89_06270	COG1294	oxidase, subunit
MKS89_06275	COG4890	Cyd operon protein YbgT
MKS89_06280	COG3790	cyd operon protein YbgE
MKS89_06290	COG0811	peptide transport
MKS89_06305	COG0823	Involved in the tonB-independent uptake of proteins
MKS89_06310	COG2885	chlorophyll binding
MKS89_06315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MKS89_06320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MKS89_06405	COG0604	alcohol dehydrogenase
MKS89_06410	COG0431	NADPH-dependent FMN reductase
MKS89_06410	COG3976	FMN-binding domain protein
MKS89_06410	COG1053	succinate dehydrogenase
MKS89_06425	COG2814	Major facilitator Superfamily
MKS89_06435	COG0471	metal ion transport
MKS89_06440	COG4565	transcriptional regulatory protein
MKS89_06445	COG2828	Protein conserved in bacteria
MKS89_06455	COG3534	alpha-L-arabinofuranosidase
MKS89_06460	COG1629	transport
MKS89_06460	COG4774	siderophore transport
MKS89_06465	COG2382	esterase
MKS89_06480	COG1120	ATPase activity
MKS89_06485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_06490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_06500	COG4592	Periplasmic binding protein
MKS89_06505	COG3433	isochorismatase activity
MKS89_06505	COG1535	isochorismatase
MKS89_06515	COG1021	2,3-dihydroxybenzoate-AMP ligase
MKS89_06520	COG1169	isochorismate synthase
MKS89_06525	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_06550	COG0765	amino acid transport
MKS89_06555	COG0765	amino acid transport
MKS89_06560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_06575	COG3414	Phosphotransferase system galactitol-specific IIB component
MKS89_06585	COG3591	Belongs to the peptidase S1B family
MKS89_06595	COG2423	ornithine cyclodeaminase activity
MKS89_06605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MKS89_06625	COG3501	Rhs element vgr protein
MKS89_06650	COG0583	DNA-binding transcription factor activity
MKS89_06655	COG2249	NAD(P)H dehydrogenase (quinone) activity
MKS89_06660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MKS89_06665	COG3842	ATPase activity
MKS89_06680	COG1840	ABC-type Fe3 transport system, periplasmic component
MKS89_06685	COG1609	Transcriptional regulator
MKS89_06695	COG0739	heme binding
MKS89_06705	COG1342	Belongs to the UPF0251 family
MKS89_06715	COG1132	(ABC) transporter
MKS89_06720	COG1132	(ABC) transporter
MKS89_06725	COG1477	protein flavinylation
MKS89_06730	COG0569	domain protein
MKS89_06735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKS89_06745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MKS89_06750	COG2985	domain, Protein
MKS89_06750	COG3273	potassium ion transport
MKS89_06755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MKS89_06760	COG1737	Transcriptional regulator
MKS89_06765	COG0076	glutamate decarboxylase activity
MKS89_06775	COG3070	regulator of competence-specific genes
MKS89_06790	COG4191	Histidine kinase
MKS89_06800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MKS89_06805	COG1032	radical SAM domain protein
MKS89_06820	COG1522	sequence-specific DNA binding
MKS89_06825	COG0626	cystathionine gamma-synthase activity
MKS89_06830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_06835	COG0765	amino acid transport
MKS89_06840	COG1126	abc transporter atp-binding protein
MKS89_06845	COG0583	DNA-binding transcription factor activity
MKS89_06850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MKS89_06860	COG2350	Protein conserved in bacteria
MKS89_06865	COG1607	acyl-coa hydrolase
MKS89_06870	COG2917	probably involved in intracellular septation
MKS89_06875	COG1301	dicarboxylic acid transport
MKS89_06880	COG0159	tryptophan synthase activity
MKS89_06885	COG0133	tryptophan synthase activity
MKS89_06890	COG0135	phosphoribosylanthranilate isomerase activity
MKS89_06890	COG0134	indole-3-glycerol-phosphate synthase activity
MKS89_06895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MKS89_06900	COG0512	Glutamine amidotransferase of anthranilate synthase
MKS89_06905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKS89_06915	COG0009	L-threonylcarbamoyladenylate synthase
MKS89_06920	COG1187	pseudouridine synthase activity
MKS89_06925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MKS89_06930	COG4988	ABC transporter
MKS89_06935	COG0492	ferredoxin-NADP+ reductase activity
MKS89_06945	COG2949	membrane
MKS89_06955	COG0281	malic enzyme
MKS89_06965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MKS89_06995	COG0247	lactate metabolic process
MKS89_06995	COG0277	FAD linked oxidase domain protein
MKS89_07010	COG3099	Belongs to the UPF0263 family
MKS89_07025	COG0417	DNA replication proofreading
MKS89_07035	COG2197	response regulator
MKS89_07040	COG0322	excinuclease ABC activity
MKS89_07045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MKS89_07050	COG0390	transport system, permease component
MKS89_07060	COG4172	Belongs to the ABC transporter superfamily
MKS89_07075	COG4168	peptide transport system, permease
MKS89_07085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MKS89_07090	COG1842	Phage shock protein A
MKS89_07100	COG1983	PspC domain protein
MKS89_07105	COG0626	cystathionine gamma-synthase activity
MKS89_07115	COG0840	transmembrane signaling receptor activity
MKS89_07120	COG0733	neurotransmitter:sodium symporter activity
MKS89_07125	COG0564	pseudouridine synthase activity
MKS89_07130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKS89_07140	COG3313	Fe-S protein
MKS89_07155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MKS89_07160	COG1061	Type III restriction enzyme res subunit
MKS89_07165	COG1187	pseudouridine synthase activity
MKS89_07170	COG2814	Major facilitator Superfamily
MKS89_07180	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_07185	COG1063	alcohol dehydrogenase
MKS89_07190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKS89_07200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKS89_07200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKS89_07210	COG4948	Mandelate Racemase Muconate Lactonizing
MKS89_07220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKS89_07250	COG1802	Transcriptional regulator
MKS89_07260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MKS89_07280	COG1280	lysine exporter protein (LysE YggA)
MKS89_07300	COG1280	lysine exporter protein (LysE YggA)
MKS89_07305	COG2192	nodulation
MKS89_07315	COG2176	DNA-directed DNA polymerase activity
MKS89_07320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKS89_07330	COG2223	nitrite transmembrane transporter activity
MKS89_07345	COG1181	Belongs to the D-alanine--D-alanine ligase family
MKS89_07370	COG1794	racemase activity, acting on amino acids and derivatives
MKS89_07375	COG0702	epimerase
MKS89_07380	COG0534	Mate efflux family protein
MKS89_07385	COG4181	ATPase activity
MKS89_07395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MKS89_07410	COG0019	diaminopimelate decarboxylase activity
MKS89_07415	COG0840	transmembrane signaling receptor activity
MKS89_07435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKS89_07445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKS89_07450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MKS89_07460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_07460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_07460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_07470	COG0383	alpha-mannosidase activity
MKS89_07480	COG1940	carbohydrate kinase activity
MKS89_07490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKS89_07495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKS89_07510	COG1846	Transcriptional regulator
MKS89_07515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKS89_07550	COG1335	isochorismatase
MKS89_07555	COG4565	transcriptional regulatory protein
MKS89_07570	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MKS89_07580	COG2301	Belongs to the HpcH HpaI aldolase family
MKS89_07600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKS89_07605	COG1254	Belongs to the acylphosphatase family
MKS89_07610	COG2920	part of a sulfur-relay system
MKS89_07615	COG0670	Belongs to the BI1 family
MKS89_07620	COG1126	abc transporter atp-binding protein
MKS89_07625	COG0765	amino acid transport
MKS89_07630	COG4597	amino acid ABC transporter
MKS89_07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_07650	COG1666	GTP binding
MKS89_07655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKS89_07670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MKS89_07670	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MKS89_07675	COG1956	GAF domain-containing protein
MKS89_07680	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MKS89_07685	COG0793	Belongs to the peptidase S41A family
MKS89_07695	COG0308	aminopeptidase N
MKS89_07710	COG0167	dihydroorotate dehydrogenase activity
MKS89_07720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MKS89_07720	COG0116	Belongs to the methyltransferase superfamily
MKS89_07725	COG0488	(ABC) transporter
MKS89_07740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MKS89_07745	COG1067	ATP-dependent peptidase activity
MKS89_07750	COG3120	sequence-specific DNA binding
MKS89_07770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MKS89_07775	COG0574	Belongs to the PEP-utilizing enzyme family
MKS89_07775	COG3848	Pyruvate phosphate dikinase
MKS89_07780	COG0028	Belongs to the TPP enzyme family
MKS89_07790	COG1414	Transcriptional regulator
MKS89_07790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MKS89_07795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKS89_07800	COG0156	8-amino-7-oxononanoate synthase activity
MKS89_07805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKS89_07810	COG3321	synthase
MKS89_07825	COG0778	Nitroreductase
MKS89_07835	COG0784	Response regulator, receiver
MKS89_07835	COG2205	protein histidine kinase activity
MKS89_07850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKS89_07855	COG0589	response to stress
MKS89_07860	COG0037	tRNA processing
MKS89_07875	COG3842	ATPase activity
MKS89_07880	COG1176	ABC-type spermidine putrescine transport system, permease component I
MKS89_07885	COG1177	transmembrane transport
MKS89_07895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MKS89_07900	COG0814	amino acid
MKS89_07905	COG0004	ammonium transporteR
MKS89_07915	COG3829	transcription factor binding
MKS89_07920	COG0746	molybdenum cofactor guanylyltransferase activity
MKS89_07925	COG1763	Mo-molybdopterin cofactor biosynthetic process
MKS89_07930	COG1940	carbohydrate kinase activity
MKS89_07935	COG0840	transmembrane signaling receptor activity
MKS89_07945	COG3001	Fructosamine kinase
MKS89_07950	COG0307	riboflavin synthase, alpha
MKS89_07955	COG0534	Mate efflux family protein
MKS89_07960	COG1793	dna ligase
MKS89_07975	COG0848	biopolymer transport protein
MKS89_07980	COG0811	peptide transport
MKS89_07985	COG0811	peptide transport
MKS89_07995	COG0584	glycerophosphoryl diester phosphodiesterase
MKS89_08005	COG1115	amino acid carrier protein
MKS89_08020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MKS89_08040	COG1609	Transcriptional regulator
MKS89_08065	COG0640	Transcriptional regulator
MKS89_08075	COG0431	NADPH-dependent FMN reductase
MKS89_08080	COG0798	PFAM Bile acid sodium symporter
MKS89_08100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MKS89_08110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKS89_08115	COG0840	transmembrane signaling receptor activity
MKS89_08120	COG4580	involved in the transport of maltose and maltodextrins
MKS89_08125	COG1874	Beta-galactosidase
MKS89_08135	COG3833	ABC-type maltose transport systems, permease component
MKS89_08140	COG1175	transmembrane transport
MKS89_08145	COG2182	Extracellular solute-binding protein
MKS89_08170	COG1063	alcohol dehydrogenase
MKS89_08175	COG4533	DNA binding
MKS89_08205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKS89_08215	COG1643	Atp-dependent helicase
MKS89_08240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MKS89_08260	COG0443	Heat shock 70 kDa protein
MKS89_08265	COG0443	Heat shock 70 kDa protein
MKS89_08280	COG0602	queuosine metabolic process
MKS89_08285	COG0561	phosphatase activity
MKS89_08300	COG2079	MmgE PrpD family protein
MKS89_08305	COG0372	Belongs to the citrate synthase family
MKS89_08310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MKS89_08320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKS89_08330	COG3768	UPF0283 membrane protein
MKS89_08335	COG3106	COG3106 Predicted ATPase
MKS89_08375	COG0494	nUDIX hydrolase
MKS89_08380	COG1760	l-serine dehydratase
MKS89_08385	COG0720	synthase
MKS89_08390	COG1017	nitric oxide dioxygenase activity
MKS89_08390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKS89_08400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_08400	COG2190	(PTS) system
MKS89_08400	COG1263	PTS System
MKS89_08415	COG0646	methionine synthase
MKS89_08415	COG1410	methionine synthase
MKS89_08430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_08435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_08440	COG1120	ATPase activity
MKS89_08445	COG0583	DNA-binding transcription factor activity
MKS89_08450	COG4774	siderophore transport
MKS89_08455	COG0840	transmembrane signaling receptor activity
MKS89_08510	COG1522	sequence-specific DNA binding
MKS89_08525	COG1914	H( )-stimulated, divalent metal cation uptake system
MKS89_08530	COG1321	iron dependent repressor
MKS89_08565	COG3706	GGDEF domain
MKS89_08615	COG3209	COG3209 Rhs family protein
MKS89_08640	COG3209	COG3209 Rhs family protein
MKS89_08655	COG3209	COG3209 Rhs family protein
MKS89_08665	COG3501	Rhs element vgr protein
MKS89_08675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKS89_08685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MKS89_08690	COG0247	lactate metabolic process
MKS89_08690	COG2181	nitrate reductase activity
MKS89_08695	COG1902	pentaerythritol trinitrate reductase activity
MKS89_08695	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKS89_08715	COG1760	l-serine dehydratase
MKS89_08745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MKS89_08750	COG0017	Asparaginyl-tRNA synthetase
MKS89_08755	COG1448	Aminotransferase
MKS89_08770	COG0402	S-adenosylhomocysteine deaminase activity
MKS89_08780	COG0840	transmembrane signaling receptor activity
MKS89_08790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MKS89_08790	COG3008	intermembrane lipid transfer
MKS89_08795	COG2995	paraquat-inducible protein a
MKS89_08805	COG0837	glucose binding
MKS89_08840	COG3842	ATPase activity
MKS89_08850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MKS89_08895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MKS89_08920	COG3833	ABC-type maltose transport systems, permease component
MKS89_08925	COG1175	transmembrane transport
MKS89_08935	COG3842	ATPase activity
MKS89_08940	COG1640	4-alpha-glucanotransferase
MKS89_08945	COG0058	SHG alpha-glucan phosphorylase activity
MKS89_08950	COG2909	trisaccharide binding
MKS89_08980	COG2199	diguanylate cyclase activity
MKS89_08990	COG0835	chemotaxis
MKS89_08990	COG0784	Response regulator, receiver
MKS89_09015	COG0583	DNA-binding transcription factor activity
MKS89_09020	COG0477	Major facilitator Superfamily
MKS89_09035	COG1538	Outer membrane efflux protein
MKS89_09050	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
MKS89_09055	COG4139	cobalamin transport
MKS89_09060	COG2988	succinylglutamate desuccinylase activity
MKS89_09065	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MKS89_09070	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MKS89_09210	COG2925	Exonuclease
MKS89_09215	COG1380	Effector of murein hydrolase LrgA
MKS89_09220	COG1346	cytolysis
MKS89_09235	COG0500	methyltransferase
MKS89_09240	COG0776	regulation of translation
MKS89_09245	COG0072	phenylalanine-tRNA ligase activity
MKS89_09245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKS89_09250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MKS89_09280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKS89_09285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKS89_09310	COG1435	thymidine kinase activity
MKS89_09315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MKS89_09320	COG1801	Protein of unknown function DUF72
MKS89_09325	COG4106	trans-aconitate 2-methyltransferase activity
MKS89_09330	COG0500	methyltransferase
MKS89_09335	COG4067	protein conserved in archaea
MKS89_09335	COG0189	ligase activity
MKS89_09345	COG0189	ligase activity
MKS89_09350	COG0463	Glycosyl transferase, family 2
MKS89_09370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MKS89_09375	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
MKS89_09380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MKS89_09385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MKS89_09390	COG1609	Transcriptional regulator
MKS89_09395	COG3070	regulator of competence-specific genes
MKS89_09400	COG0297	glycogen (starch) synthase activity
MKS89_09405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MKS89_09410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKS89_09435	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MKS89_09440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MKS89_09445	COG0542	response to heat
MKS89_09450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MKS89_09455	COG1278	Cold shock
MKS89_09465	COG1187	pseudouridine synthase activity
MKS89_09470	COG0140	phosphoribosyl-ATP diphosphatase activity
MKS89_09470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MKS89_09480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MKS89_09485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MKS89_09490	COG0131	Imidazoleglycerol-phosphate dehydratase
MKS89_09490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MKS89_09495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MKS89_09500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MKS89_09505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MKS89_09510	COG1757	Na H antiporter
MKS89_09515	COG2916	Histone family protein nucleoid-structuring protein H-NS
MKS89_09520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_09525	COG0482	sulfurtransferase activity
MKS89_09535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MKS89_09540	COG0501	Belongs to the peptidase M48B family
MKS89_09550	COG0754	glutathionylspermidine amidase activity
MKS89_09560	COG1842	Phage shock protein A
MKS89_09565	COG0137	argininosuccinate synthase activity
MKS89_09575	COG3766	membrane
MKS89_09585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MKS89_09590	COG2226	methyltransferase
MKS89_09595	COG0156	8-amino-7-oxononanoate synthase activity
MKS89_09600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MKS89_09655	COG0488	(ABC) transporter
MKS89_09675	COG2205	protein histidine kinase activity
MKS89_09690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MKS89_09700	COG0653	protein targeting
MKS89_09725	COG4120	Belongs to the binding-protein-dependent transport system permease family
MKS89_09735	COG3092	negative regulation of chromosome organization
MKS89_09740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MKS89_09745	COG0280	phosphate acetyltransferase
MKS89_09745	COG0857	belongs to the CobB CobQ family
MKS89_09750	COG0435	Glutathione S-transferase
MKS89_09755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_09760	COG1621	beta-fructofuranosidase activity
MKS89_09770	COG1263	PTS System
MKS89_09770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_09780	COG0745	RESPONSE REGULATOR receiver
MKS89_09790	COG4139	cobalamin transport
MKS89_09800	COG2204	response regulator
MKS89_09805	COG4191	Histidine kinase
MKS89_09805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_09810	COG3852	Histidine kinase
MKS89_09820	COG3437	response regulator, receiver
MKS89_09835	COG0702	epimerase
MKS89_09840	COG1733	regulation of RNA biosynthetic process
MKS89_09850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKS89_09855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKS89_09860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MKS89_09865	COG4948	Mandelate Racemase Muconate Lactonizing
MKS89_09875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MKS89_09880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MKS89_09885	COG1984	allophanate hydrolase subunit 2
MKS89_09890	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MKS89_09895	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MKS89_09900	COG2084	Dehydrogenase
MKS89_09905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MKS89_09940	COG1280	lysine exporter protein (LysE YggA)
MKS89_09945	COG1280	lysine exporter protein (LysE YggA)
MKS89_10005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MKS89_10015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKS89_10035	COG1053	succinate dehydrogenase
MKS89_10040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MKS89_10045	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MKS89_10050	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MKS89_10055	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MKS89_10060	COG3290	protein histidine kinase activity
MKS89_10065	COG4565	transcriptional regulatory protein
MKS89_10075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MKS89_10080	COG1349	DNA-binding transcription factor activity
MKS89_10090	COG2271	Major facilitator Superfamily
MKS89_10105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKS89_10110	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKS89_10115	COG0789	Transcriptional regulator
MKS89_10125	COG0616	signal peptide processing
MKS89_10130	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_10135	COG0835	chemotaxis
MKS89_10135	COG0784	Response regulator, receiver
MKS89_10140	COG1940	carbohydrate kinase activity
MKS89_10145	COG0469	pyruvate kinase activity
MKS89_10150	COG4667	esterase of the alpha-beta hydrolase superfamily
MKS89_10160	COG0733	neurotransmitter:sodium symporter activity
MKS89_10175	COG1263	PTS System
MKS89_10175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_10180	COG0084	hydrolase, TatD family'
MKS89_10185	COG0470	DNA polymerase III
MKS89_10190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MKS89_10195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MKS89_10225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKS89_10235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MKS89_10240	COG1399	metal-binding, possibly nucleic acid-binding protein
MKS89_10245	COG0424	maF-like protein
MKS89_10250	COG0564	pseudouridine synthase activity
MKS89_10255	COG1530	ribonuclease E activity
MKS89_10260	COG0659	secondary active sulfate transmembrane transporter activity
MKS89_10265	COG1012	belongs to the aldehyde dehydrogenase family
MKS89_10265	COG1454	alcohol dehydrogenase
MKS89_10270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKS89_10275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKS89_10280	COG3248	Nucleoside-binding outer membrane protein
MKS89_10285	COG3081	Nucleoid-associated protein
MKS89_10290	COG3082	Protein of unknown function (DUF1414)
MKS89_10295	COG3083	sulfuric ester hydrolase activity
MKS89_10315	COG0582	viral genome integration into host DNA
MKS89_10360	COG1309	transcriptional regulator
MKS89_10405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_10410	COG4597	amino acid ABC transporter
MKS89_10415	COG0765	amino acid transport
MKS89_10420	COG1126	abc transporter atp-binding protein
MKS89_10430	COG3457	Alanine racemase
MKS89_10440	COG0252	asparaginase activity
MKS89_10460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKS89_10465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_10485	COG2272	Belongs to the type-B carboxylesterase lipase family
MKS89_10505	COG1136	(ABC) transporter
MKS89_10505	COG0577	efflux transmembrane transporter activity
MKS89_10510	COG0577	efflux transmembrane transporter activity
MKS89_10510	COG1136	(ABC) transporter
MKS89_10530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKS89_10535	COG0842	Transport permease protein
MKS89_10540	COG1131	(ABC) transporter
MKS89_10560	COG0601	transmembrane transport
MKS89_10565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKS89_10570	COG0444	Belongs to the ABC transporter superfamily
MKS89_10580	COG2207	Transcriptional regulator
MKS89_10580	COG1917	Cupin 2, conserved barrel domain protein
MKS89_10590	COG2130	NADP-dependent
MKS89_10600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKS89_10605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MKS89_10635	COG0835	chemotaxis
MKS89_10645	COG1192	Involved in chromosome partitioning
MKS89_10650	COG2201	protein-glutamate methylesterase activity
MKS89_10655	COG0784	Response regulator, receiver
MKS89_10655	COG2198	Histidine kinase
MKS89_10655	COG0643	Histidine kinase
MKS89_10660	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MKS89_10690	COG2062	phosphohistidine phosphatase, SixA
MKS89_10700	COG3102	Protein conserved in bacteria
MKS89_10730	COG1918	ferrous iron import across plasma membrane
MKS89_10735	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MKS89_10740	COG1121	(ABC) transporter
MKS89_10745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKS89_10760	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKS89_10765	COG0567	Dehydrogenase, E1 component
MKS89_10775	COG1053	succinate dehydrogenase
MKS89_10780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MKS89_10785	COG2009	succinate dehydrogenase
MKS89_10795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MKS89_10815	COG0033	Phosphoglucomutase
MKS89_10820	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MKS89_10825	COG0596	Alpha beta hydrolase
MKS89_10830	COG0716	FMN binding
MKS89_10835	COG0735	belongs to the Fur family
MKS89_10840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKS89_10845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKS89_10850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MKS89_10855	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MKS89_10855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MKS89_10870	COG3101	peptidyl-lysine hydroxylation
MKS89_10875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MKS89_10880	COG2890	protein-(glutamine-N5) methyltransferase activity
MKS89_10885	COG2840	Smr protein MutS2
MKS89_10895	COG1684	flagellar biosynthetic protein fliR
MKS89_10900	COG1987	bacterial-type flagellum assembly
MKS89_10925	COG1580	Controls the rotational direction of flagella during chemotaxis
MKS89_10950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MKS89_10960	COG1677	Flagellar hook-basal body complex protein FliE
MKS89_10980	COG1516	flagellar protein fliS
MKS89_10990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MKS89_10995	COG1334	flagellar protein FlaG
MKS89_11005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKS89_11015	COG2837	iron assimilation
MKS89_11025	COG1393	Belongs to the ArsC family
MKS89_11035	COG1876	peptidase activity
MKS89_11045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MKS89_11050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKS89_11055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKS89_11060	COG0840	transmembrane signaling receptor activity
MKS89_11070	COG4783	chaperone-mediated protein folding
MKS89_11075	COG1393	Belongs to the ArsC family
MKS89_11095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MKS89_11100	COG0737	Belongs to the 5'-nucleotidase family
MKS89_11105	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MKS89_11110	COG2912	Transglutaminase-like superfamily
MKS89_11115	COG3094	Invasion gene expression up-regulator, SirB
MKS89_11120	COG2890	protein-(glutamine-N5) methyltransferase activity
MKS89_11125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MKS89_11130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MKS89_11135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MKS89_11145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MKS89_11150	COG0193	aminoacyl-tRNA hydrolase activity
MKS89_11155	COG0012	GTP binding
MKS89_11235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKS89_11245	COG3951	Flagellar rod assembly protein muramidase FlgJ
MKS89_11245	COG1705	Flagellar rod assembly protein muramidase FlgJ
MKS89_11250	COG1706	bacterial-type flagellum-dependent cell motility
MKS89_11255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MKS89_11265	COG4787	bacterial-type flagellum-dependent cell motility
MKS89_11285	COG1815	bacterial-type flagellum-dependent cell motility
MKS89_11290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MKS89_11295	COG0784	Response regulator, receiver
MKS89_11295	COG0835	chemotaxis
MKS89_11340	COG3047	cAMP biosynthetic process
MKS89_11355	COG1846	Transcriptional regulator
MKS89_11370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKS89_11375	COG2217	Heavy metal translocating P-type atpase
MKS89_11375	COG2608	mercury ion transmembrane transporter activity
MKS89_11380	COG3735	TraB family
MKS89_11390	COG2840	Smr protein MutS2
MKS89_11395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MKS89_11400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MKS89_11405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MKS89_11410	COG1051	belongs to the nudix hydrolase family
MKS89_11415	COG0121	glutamine amidotransferase
MKS89_11420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MKS89_11440	COG0328	RNA-DNA hybrid ribonuclease activity
MKS89_11445	COG2226	methyltransferase
MKS89_11450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKS89_11455	COG0741	lytic transglycosylase activity
MKS89_11455	COG1388	LysM domain
MKS89_11475	COG0825	malonyl-CoA metabolic process
MKS89_11480	COG0587	DNA-directed DNA polymerase activity
MKS89_11485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MKS89_11490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKS89_11495	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKS89_11500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MKS89_11505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKS89_11510	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
MKS89_11520	COG0750	zinc metalloprotease
MKS89_11525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MKS89_11530	COG0575	Belongs to the CDS family
MKS89_11535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MKS89_11540	COG0233	cytoplasmic translational termination
MKS89_11545	COG0528	UMP kinase activity
MKS89_11550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MKS89_11555	COG0052	Belongs to the universal ribosomal protein uS2 family
MKS89_11560	COG0024	Methionine aminopeptidase
MKS89_11565	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MKS89_11575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MKS89_11580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MKS89_11585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKS89_11605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKS89_11605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKS89_11610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MKS89_11615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MKS89_11630	COG1073	alpha beta
MKS89_11635	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MKS89_11640	COG2252	PERMEase
MKS89_11645	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKS89_11650	COG4067	protein conserved in archaea
MKS89_11650	COG0189	ligase activity
MKS89_11655	COG0189	ligase activity
MKS89_11660	COG0733	neurotransmitter:sodium symporter activity
MKS89_11665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKS89_11670	COG0697	spore germination
MKS89_11675	COG0583	DNA-binding transcription factor activity
MKS89_11700	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MKS89_11710	COG1805	sodium ion transport
MKS89_11715	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MKS89_11720	COG0271	Belongs to the BolA IbaG family
MKS89_11745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKS89_11755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MKS89_11760	COG2166	iron-sulfur cluster assembly
MKS89_11765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MKS89_11770	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MKS89_11775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MKS89_11775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MKS89_11785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKS89_11790	COG1074	ATP-dependent DNA helicase activity
MKS89_11795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MKS89_11805	COG3141	response to X-ray
MKS89_11810	COG2171	N-acyltransferase activity
MKS89_11815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MKS89_11825	COG1609	Transcriptional regulator
MKS89_11835	COG1022	Amp-dependent synthetase and ligase
MKS89_11845	COG0583	DNA-binding transcription factor activity
MKS89_11850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKS89_11855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MKS89_11865	COG0560	Phosphoserine phosphatase
MKS89_11875	COG0813	purine-nucleoside phosphorylase activity
MKS89_11880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MKS89_11885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKS89_11890	COG0084	hydrolase, TatD family'
MKS89_11900	COG3022	response to hydroperoxide
MKS89_11905	COG1115	amino acid carrier protein
MKS89_11920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MKS89_11930	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
MKS89_11935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MKS89_11940	COG0083	homoserine kinase activity
MKS89_11950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKS89_11960	COG0745	RESPONSE REGULATOR receiver
MKS89_11965	COG0784	Response regulator, receiver
MKS89_11965	COG2198	Histidine kinase
MKS89_11965	COG5002	protein histidine kinase activity
MKS89_11975	COG1242	4 iron, 4 sulfur cluster binding
MKS89_11980	COG0067	glutamate synthase
MKS89_11980	COG0069	glutamate synthase activity
MKS89_11980	COG0070	glutamate synthase
MKS89_11990	COG0067	glutamate synthase
MKS89_11990	COG0069	glutamate synthase activity
MKS89_11990	COG0070	glutamate synthase
MKS89_11995	COG0493	'glutamate synthase
MKS89_12000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MKS89_12010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKS89_12015	COG2860	membrane
MKS89_12020	COG0583	DNA-binding transcription factor activity
MKS89_12025	COG0730	response to heat
MKS89_12030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MKS89_12035	COG0505	Belongs to the CarA family
MKS89_12040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MKS89_12045	COG0494	nUDIX hydrolase
MKS89_12050	COG0653	protein targeting
MKS89_12060	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MKS89_12065	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MKS89_12070	COG0849	cell division
MKS89_12075	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MKS89_12080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MKS89_12090	COG0772	Belongs to the SEDS family
MKS89_12095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MKS89_12105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MKS89_12110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MKS89_12115	COG0768	penicillin binding
MKS89_12120	COG3116	cell division
MKS89_12125	COG0275	rRNA processing
MKS89_12135	COG0534	Mate efflux family protein
MKS89_12145	COG0840	transmembrane signaling receptor activity
MKS89_12150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MKS89_12155	COG3107	peptidoglycan biosynthetic process
MKS89_12165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MKS89_12170	COG2823	Periplasmic or secreted lipoprotein
MKS89_12175	COG2969	positive regulation of protein catabolic process
MKS89_12180	COG0625	glutathione transferase activity
MKS89_12185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MKS89_12190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MKS89_12195	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MKS89_12200	COG3105	Protein conserved in bacteria
MKS89_12205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKS89_12210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKS89_12215	COG0335	large ribosomal subunit rRNA binding
MKS89_12225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MKS89_12235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MKS89_12240	COG4137	Cytochrome C assembly protein
MKS89_12245	COG4536	flavin adenine dinucleotide binding
MKS89_12250	COG1854	S-ribosylhomocysteine lyase activity
MKS89_12255	COG2918	glutathione biosynthetic process
MKS89_12260	COG0612	Peptidase, M16
MKS89_12265	COG1238	metal cluster binding
MKS89_12275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MKS89_12285	COG3630	sodium ion export across plasma membrane
MKS89_12320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MKS89_12325	COG0527	aspartate kinase activity
MKS89_12330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MKS89_12335	COG2137	regulation of response to DNA damage stimulus
MKS89_12340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MKS89_12345	COG1546	Belongs to the CinA family
MKS89_12350	COG1414	Transcriptional regulator
MKS89_12355	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_12360	COG1917	Cupin 2, conserved barrel domain protein
MKS89_12375	COG0800	Aldolase
MKS89_12390	COG3842	ATPase activity
MKS89_12395	COG0395	ABC-type sugar transport system, permease component
MKS89_12400	COG1175	transmembrane transport
MKS89_12405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MKS89_12420	COG0823	Involved in the tonB-independent uptake of proteins
MKS89_12425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MKS89_12430	COG0784	Response regulator, receiver
MKS89_12430	COG3437	response regulator, receiver
MKS89_12435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_12435	COG4191	Histidine kinase
MKS89_12445	COG5297	Belongs to the glycosyl hydrolase family 6
MKS89_12450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKS89_12455	COG1388	LysM domain
MKS89_12455	COG4942	peptidase
MKS89_12460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MKS89_12465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MKS89_12470	COG0585	pseudouridine synthase activity
MKS89_12480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MKS89_12485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MKS89_12490	COG1968	undecaprenyl-diphosphatase activity
MKS89_12495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKS89_12500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MKS89_12505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MKS89_12510	COG0596	Alpha beta hydrolase
MKS89_12515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MKS89_12520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MKS89_12525	COG1610	YqeY-like protein
MKS89_12530	COG0358	DNA primase activity
MKS89_12600	COG0450	alkyl hydroperoxide reductase
MKS89_12625	COG1368	sulfuric ester hydrolase activity
MKS89_12640	COG0604	alcohol dehydrogenase
MKS89_12690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKS89_12815	COG2204	response regulator
MKS89_12825	COG0840	transmembrane signaling receptor activity
MKS89_12830	COG3119	arylsulfatase activity
MKS89_12840	COG0641	radical SAM
MKS89_12845	COG3119	arylsulfatase activity
MKS89_12855	COG3119	arylsulfatase activity
MKS89_12860	COG0641	radical SAM
MKS89_12865	COG2149	membrane
MKS89_12885	COG1263	PTS System
MKS89_12885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_12885	COG2190	(PTS) system
MKS89_12890	COG0840	transmembrane signaling receptor activity
MKS89_12900	COG1278	Cold shock
MKS89_12920	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MKS89_12990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MKS89_12995	COG1349	DNA-binding transcription factor activity
MKS89_13000	COG0469	pyruvate kinase activity
MKS89_13010	COG0668	transmembrane transport
MKS89_13020	COG0126	phosphoglycerate kinase activity
MKS89_13025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MKS89_13030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKS89_13035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MKS89_13040	COG3091	SprT-like family
MKS89_13045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MKS89_13050	COG0189	ligase activity
MKS89_13055	COG1678	Uncharacterized ACR, COG1678
MKS89_13060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MKS89_13070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MKS89_13075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MKS89_13080	COG0762	integral membrane protein
MKS89_13085	COG1872	DUF167
MKS89_13095	COG3437	response regulator, receiver
MKS89_13100	COG0784	Response regulator, receiver
MKS89_13100	COG2205	protein histidine kinase activity
MKS89_13100	COG5002	protein histidine kinase activity
MKS89_13120	COG1366	Belongs to the anti-sigma-factor antagonist family
MKS89_13130	COG3040	lipid binding
MKS89_13165	COG3209	COG3209 Rhs family protein
MKS89_13205	COG3209	COG3209 Rhs family protein
MKS89_13240	COG3501	Rhs element vgr protein
MKS89_13245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MKS89_13250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MKS89_13255	COG2066	Belongs to the glutaminase family
MKS89_13260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MKS89_13270	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MKS89_13325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MKS89_13330	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MKS89_13335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKS89_13340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MKS89_13345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MKS89_13350	COG2967	ApaG domain
MKS89_13365	COG3610	response to peptide
MKS89_13370	COG2966	Psort location CytoplasmicMembrane, score
MKS89_13375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MKS89_13385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MKS89_13390	COG0142	geranyltranstransferase activity
MKS89_13395	COG0039	L-malate dehydrogenase activity
MKS89_13400	COG1438	arginine binding
MKS89_13405	COG2358	TRAP transporter, solute receptor (TAXI family
MKS89_13415	COG0589	response to stress
MKS89_13430	COG2186	Transcriptional regulator
MKS89_13440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKS89_13455	COG0246	Mannitol dehydrogenase
MKS89_13465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_13470	COG0800	Aldolase
MKS89_13495	COG0633	Ferredoxin
MKS89_13505	COG0697	spore germination
MKS89_13520	COG2971	BadF BadG BcrA BcrD
MKS89_13535	COG0395	ABC-type sugar transport system, permease component
MKS89_13540	COG1175	transmembrane transport
MKS89_13565	COG0312	modulator of DNA gyrase
MKS89_13570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKS89_13575	COG3164	Protein of unknown function
MKS89_13585	COG0424	maF-like protein
MKS89_13590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MKS89_13595	COG1792	Involved in formation and maintenance of cell shape
MKS89_13600	COG1077	Cell shape determining protein MreB Mrl
MKS89_13605	COG2199	diguanylate cyclase activity
MKS89_13605	COG2200	EAL domain
MKS89_13610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MKS89_13625	COG0309	Hydrogenase expression formation protein (HypE)
MKS89_13635	COG0298	carbon dioxide binding
MKS89_13640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MKS89_13660	COG3383	formate dehydrogenase (NAD+) activity
MKS89_13665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKS89_13670	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MKS89_13680	COG3260	NADH ubiquinone oxidoreductase 20
MKS89_13685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MKS89_13690	COG3261	NADH dehydrogenase
MKS89_13690	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
MKS89_13695	COG0651	ATP synthesis coupled electron transport
MKS89_13700	COG4237	Hydrogenase 4 membrane
MKS89_13705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKS89_13710	COG0650	Formate hydrogenlyase subunit 4
MKS89_13715	COG0651	ATP synthesis coupled electron transport
MKS89_13720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKS89_13725	COG0527	aspartate kinase activity
MKS89_13730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MKS89_13740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MKS89_13755	COG0629	single-stranded DNA binding
MKS89_13810	COG0175	sulfate reduction
MKS89_13815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKS89_13820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKS89_13880	COG0735	belongs to the Fur family
MKS89_13910	COG0359	binds to the 23S rRNA
MKS89_13915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MKS89_13920	COG2965	DNA replication, synthesis of RNA primer
MKS89_13925	COG0360	Binds together with S18 to 16S ribosomal RNA
MKS89_13940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MKS89_13945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKS89_13950	COG0049	tRNA binding
MKS89_13970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MKS89_13975	COG2964	Protein conserved in bacteria
MKS89_13980	COG0545	Peptidyl-prolyl cis-trans isomerase
MKS89_13990	COG2900	Belongs to the SlyX family
MKS89_13995	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MKS89_14000	COG0330	HflC and HflK could
MKS89_14005	COG0330	HflC and HflK could
MKS89_14010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MKS89_14015	COG1923	regulation of RNA biosynthetic process
MKS89_14020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MKS89_14025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MKS89_14030	COG0860	N-Acetylmuramoyl-L-alanine amidase
MKS89_14035	COG0802	atpase or kinase
MKS89_14040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MKS89_14070	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MKS89_14075	COG1162	GTPase activity
MKS89_14080	COG0688	phosphatidylethanolamine metabolic process
MKS89_14085	COG0471	metal ion transport
MKS89_14095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MKS89_14100	COG4942	peptidase
MKS89_14110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MKS89_14115	COG2816	NAD+ diphosphatase activity
MKS89_14120	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MKS89_14125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MKS89_14130	COG0085	RNA polymerase activity
MKS89_14135	COG0222	ribosome binding
MKS89_14140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MKS89_14145	COG0081	regulation of translation
MKS89_14150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MKS89_14155	COG0250	Participates in transcription elongation, termination and antitermination
MKS89_14160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKS89_14165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MKS89_14190	COG1072	(Pantothenic acid kinase))
MKS89_14200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MKS89_14210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKS89_14225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MKS89_14240	COG3118	belongs to the thioredoxin family
MKS89_14245	COG0513	Belongs to the DEAD box helicase family
MKS89_14250	COG0248	Ppx GppA phosphatase
MKS89_14255	COG0784	Response regulator, receiver
MKS89_14255	COG2205	protein histidine kinase activity
MKS89_14255	COG2198	Histidine kinase
MKS89_14260	COG2188	Transcriptional regulator
MKS89_14275	COG2814	Major facilitator Superfamily
MKS89_14290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKS89_14295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MKS89_14300	COG0511	ligase activity, forming carbon-carbon bonds
MKS89_14305	COG0439	Biotin carboxylase
MKS89_14310	COG2264	protein methyltransferase activity
MKS89_14320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MKS89_14350	COG0583	DNA-binding transcription factor activity
MKS89_14355	COG1733	regulation of RNA biosynthetic process
MKS89_14365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MKS89_14375	COG0840	transmembrane signaling receptor activity
MKS89_14385	COG0138	bifunctional purine biosynthesis protein purh
MKS89_14390	COG0151	Belongs to the GarS family
MKS89_14400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKS89_14405	COG2183	response to ionizing radiation
MKS89_14415	COG0596	Alpha beta hydrolase
MKS89_14420	COG1040	competence protein
MKS89_14425	COG0316	Belongs to the HesB IscA family
MKS89_14425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MKS89_14430	COG0494	nUDIX hydrolase
MKS89_14435	COG1218	3'(2'),5'-bisphosphate nucleotidase
MKS89_14445	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MKS89_14450	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MKS89_14455	COG3156	type II secretion system protein K
MKS89_14460	COG4795	General secretion pathway protein
MKS89_14465	COG2165	general secretion pathway protein
MKS89_14470	COG2165	general secretion pathway protein
MKS89_14475	COG2165	general secretion pathway protein
MKS89_14480	COG1459	type II secretion system
MKS89_14485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKS89_14495	COG3031	protein transport across the cell outer membrane
MKS89_14500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MKS89_14505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MKS89_14510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MKS89_14520	COG0456	acetyltransferase
MKS89_14525	COG1490	D-aminoacyl-tRNA deacylase activity
MKS89_14530	COG1295	ribonuclease BN
MKS89_14535	COG1217	gtp-binding protein TYPA
MKS89_14540	COG0174	glutamine synthetase
MKS89_14545	COG3852	Histidine kinase
MKS89_14550	COG2204	response regulator
MKS89_14615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MKS89_14620	COG4206	TonB-dependent receptor
MKS89_14625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MKS89_14630	COG2368	4-hydroxyphenylacetate
MKS89_14640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKS89_14645	COG0167	dihydroorotate dehydrogenase activity
MKS89_14650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MKS89_14665	COG2816	NAD+ diphosphatase activity
MKS89_14670	COG0523	cobalamin synthesis protein
MKS89_14685	COG0523	cobalamin synthesis protein
MKS89_14690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKS89_14695	COG1121	(ABC) transporter
MKS89_14710	COG1132	(ABC) transporter
MKS89_14715	COG1309	transcriptional regulator
MKS89_14725	COG3501	Rhs element vgr protein
MKS89_14805	COG2084	Dehydrogenase
MKS89_14810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_14815	COG1349	DNA-binding transcription factor activity
MKS89_14840	COG1501	Belongs to the glycosyl hydrolase 31 family
MKS89_14845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKS89_14850	COG0583	DNA-binding transcription factor activity
MKS89_14865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKS89_14870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MKS89_14875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKS89_14880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MKS89_14885	COG2937	Belongs to the GPAT DAPAT family
MKS89_14890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MKS89_14895	COG3161	chorismate lyase activity
MKS89_14920	COG2177	Part of the ABC transporter FtsEX involved in
MKS89_14925	COG2884	Cell division ATP-binding protein ftsE
MKS89_14930	COG0552	protein localization to endoplasmic reticulum
MKS89_14935	COG0742	ribosomal rna small subunit methyltransferase
MKS89_14940	COG2095	MarC family integral membrane protein
MKS89_14960	COG0783	Belongs to the Dps family
MKS89_14965	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MKS89_14970	COG1280	lysine exporter protein (LysE YggA)
MKS89_14975	COG2267	carboxylic ester hydrolase activity
MKS89_14980	COG0561	phosphatase activity
MKS89_14985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKS89_14995	COG2977	Belongs to the P-Pant transferase superfamily
MKS89_15010	COG3148	PFAM DTW domain containing protein
MKS89_15015	COG1011	Hydrolase
MKS89_15020	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MKS89_15030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MKS89_15035	COG0019	diaminopimelate decarboxylase activity
MKS89_15065	COG2959	enzyme of heme biosynthesis
MKS89_15070	COG3071	HemY protein
MKS89_15085	COG3078	GTPase activator activity
MKS89_15105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKS89_15105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKS89_15115	COG0084	hydrolase, TatD family'
MKS89_15120	COG0805	protein transport
MKS89_15125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKS89_15135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MKS89_15140	COG3165	ubiquinone biosynthetic process from chorismate
MKS89_15145	COG2226	methyltransferase
MKS89_15150	COG1322	Protein conserved in bacteria
MKS89_15175	COG2160	L-arabinose isomerase activity
MKS89_15185	COG1069	ribulokinase activity
MKS89_15190	COG1879	ABC-type sugar transport system periplasmic component
MKS89_15195	COG1129	ABC transporter
MKS89_15200	COG1172	Belongs to the binding-protein-dependent transport system permease family
MKS89_15220	COG2329	Antibiotic biosynthesis monooxygenase
MKS89_15230	COG0583	DNA-binding transcription factor activity
MKS89_15245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKS89_15250	COG0028	Belongs to the TPP enzyme family
MKS89_15255	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MKS89_15255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MKS89_15290	COG2378	regulation of single-species biofilm formation
MKS89_15295	COG0702	epimerase
MKS89_15305	COG2188	Transcriptional regulator
MKS89_15310	COG1070	Carbohydrate kinase
MKS89_15315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKS89_15335	COG2081	HI0933 family
MKS89_15345	COG1528	Iron-storage protein
MKS89_15365	COG0742	ribosomal rna small subunit methyltransferase
MKS89_15370	COG1522	sequence-specific DNA binding
MKS89_15380	COG0006	proline dipeptidase activity
MKS89_15390	COG1012	belongs to the aldehyde dehydrogenase family
MKS89_15410	COG4175	Glycine betaine
MKS89_15415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MKS89_15420	COG2022	thiamine diphosphate biosynthetic process
MKS89_15425	COG2104	thiamine diphosphate biosynthetic process
MKS89_15430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKS89_15445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MKS89_15450	COG3940	Belongs to the glycosyl hydrolase 43 family
MKS89_15455	COG2211	Major facilitator Superfamily
MKS89_15500	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MKS89_15505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKS89_15510	COG1739	Uncharacterized protein family UPF0029
MKS89_15530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MKS89_15535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MKS89_15540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MKS89_15550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MKS89_15555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MKS89_15565	COG0356	it plays a direct role in the translocation of protons across the membrane
MKS89_15575	COG1475	DNA binding
MKS89_15580	COG1192	Involved in chromosome partitioning
MKS89_15590	COG0445	tRNA wobble uridine modification
MKS89_15595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKS89_15605	COG0732	type I restriction modification DNA specificity domain
MKS89_15640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MKS89_15645	COG0706	membrane insertase activity
MKS89_15655	COG0594	ribonuclease P activity
MKS89_15665	COG1126	abc transporter atp-binding protein
MKS89_15710	COG2259	Doxx family
MKS89_15720	COG3085	chromosome segregation
MKS89_15725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_15725	COG2213	PTS system mannitol-specific
MKS89_15735	COG3722	fumarate hydratase activity
MKS89_15770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MKS89_15805	COG1444	tRNA N-acetyltransferase activity
MKS89_15835	COG0217	transcriptional regulatory protein
MKS89_15840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MKS89_15845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKS89_15850	COG1845	cytochrome c oxidase, subunit III
MKS89_15855	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MKS89_15860	COG0109	protoheme IX farnesyltransferase activity
MKS89_15865	COG0058	SHG alpha-glucan phosphorylase activity
MKS89_15870	COG1640	4-alpha-glucanotransferase
MKS89_15875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MKS89_15880	COG0277	FAD linked oxidase domain protein
MKS89_15910	COG0163	prenyltransferase activity
MKS89_15915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MKS89_15925	COG5520	Belongs to the glycosyl hydrolase 30 family
MKS89_15935	COG0110	maltose O-acetyltransferase activity
MKS89_15960	COG1067	ATP-dependent peptidase activity
MKS89_15965	COG0534	Mate efflux family protein
MKS89_15970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKS89_15975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKS89_15985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MKS89_15990	COG1940	carbohydrate kinase activity
MKS89_15995	COG5001	Diguanylate cyclase
MKS89_15995	COG3300	MHYT domain
MKS89_16010	COG2818	Glycosylase
MKS89_16015	COG1984	allophanate hydrolase subunit 2
MKS89_16025	COG0511	ligase activity, forming carbon-carbon bonds
MKS89_16045	COG2239	Acts as a magnesium transporter
MKS89_16050	COG2113	Glycine betaine
MKS89_16055	COG4176	ABC-type proline glycine betaine transport system permease component
MKS89_16060	COG4175	Glycine betaine
MKS89_16075	COG3338	carbonate dehydratase activity
MKS89_16080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MKS89_16090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MKS89_16095	COG3437	response regulator, receiver
MKS89_16095	COG0784	Response regulator, receiver
MKS89_16100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_16100	COG4191	Histidine kinase
MKS89_16105	COG4191	Histidine kinase
MKS89_16105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_16125	COG0583	DNA-binding transcription factor activity
MKS89_16140	COG1785	Belongs to the alkaline phosphatase family
MKS89_16150	COG2264	protein methyltransferase activity
MKS89_16160	COG1022	Amp-dependent synthetase and ligase
MKS89_16180	COG0642	Histidine kinase
MKS89_16195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKS89_16200	COG0456	acetyltransferase
MKS89_16205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKS89_16210	COG0662	Cupin 2, conserved barrel domain protein
MKS89_16215	COG0527	aspartate kinase activity
MKS89_16220	COG0252	asparaginase activity
MKS89_16230	COG0840	transmembrane signaling receptor activity
MKS89_16235	COG1741	Belongs to the pirin family
MKS89_16245	COG0668	transmembrane transport
MKS89_16255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MKS89_16285	COG0784	Response regulator, receiver
MKS89_16285	COG0835	chemotaxis
MKS89_16295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKS89_16300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKS89_16310	COG0583	DNA-binding transcription factor activity
MKS89_16315	COG1486	melibiose metabolic process
MKS89_16320	COG3530	Putative quorum-sensing-regulated virulence factor
MKS89_16325	COG4104	PAAR repeat-containing protein
MKS89_16345	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
MKS89_16355	COG1846	Transcriptional regulator
MKS89_16360	COG1764	response to oxidative stress
MKS89_16365	COG3118	belongs to the thioredoxin family
MKS89_16395	COG4215	(ABC) transporter
MKS89_16400	COG4160	amino acid transport
MKS89_16405	COG4598	ABC transporter
MKS89_16415	COG1280	lysine exporter protein (LysE YggA)
MKS89_16420	COG1522	sequence-specific DNA binding
MKS89_16425	COG2211	Major facilitator Superfamily
MKS89_16430	COG3250	beta-galactosidase activity
MKS89_16465	COG0714	Associated with various cellular activities
MKS89_16480	COG1448	Aminotransferase
MKS89_16490	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKS89_16500	COG3604	Transcriptional regulator
MKS89_16505	COG1278	Cold shock
MKS89_16510	COG3036	rescue of stalled ribosome
MKS89_16520	COG4999	Histidine kinase
MKS89_16520	COG3850	Histidine kinase
MKS89_16520	COG3437	response regulator, receiver
MKS89_16520	COG2205	protein histidine kinase activity
MKS89_16530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MKS89_16530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MKS89_16540	COG0516	GMP reductase activity
MKS89_16545	COG0531	amino acid
MKS89_16555	COG4303	Ethanolamine ammonia lyase large subunit
MKS89_16580	COG2199	diguanylate cyclase activity
MKS89_16580	COG2203	Gaf domain
MKS89_16620	COG2723	6-phospho-beta-galactosidase activity
MKS89_16625	COG1263	PTS System
MKS89_16625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_16630	COG3265	gluconokinase activity
MKS89_16635	COG1609	Transcriptional regulator
MKS89_16640	COG0583	DNA-binding transcription factor activity
MKS89_16645	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_16650	COG0840	transmembrane signaling receptor activity
MKS89_16655	COG4399	Belongs to the UPF0754 family
MKS89_16660	COG1132	(ABC) transporter
MKS89_16680	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MKS89_16690	COG3706	GGDEF domain
MKS89_16700	COG3272	Protein of unknown function (DUF1722)
MKS89_16705	COG0789	Transcriptional regulator
MKS89_16710	COG0415	Belongs to the DNA photolyase family
MKS89_16715	COG1388	LysM domain
MKS89_16715	COG1376	ErfK ybiS ycfS ynhG family protein
MKS89_16725	COG0513	Belongs to the DEAD box helicase family
MKS89_16730	COG0840	transmembrane signaling receptor activity
MKS89_16740	COG0573	inorganic phosphate transmembrane transporter activity
MKS89_16745	COG0581	inorganic phosphate transmembrane transporter activity
MKS89_16750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MKS89_16755	COG3314	Sporulation integral membrane protein YlbJ
MKS89_16765	COG0739	heme binding
MKS89_16770	COG5001	Diguanylate cyclase
MKS89_16780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKS89_16785	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
MKS89_16790	COG2814	Major facilitator Superfamily
MKS89_16795	COG0583	DNA-binding transcription factor activity
MKS89_16800	COG0667	Aldo Keto reductase
MKS89_16805	COG0583	DNA-binding transcription factor activity
MKS89_16810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKS89_16830	COG0179	Fumarylacetoacetate (FAA) hydrolase
MKS89_16835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MKS89_16845	COG2190	(PTS) system
MKS89_16845	COG1263	PTS System
MKS89_16845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_16850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKS89_16850	COG2190	(PTS) system
MKS89_16850	COG1263	PTS System
MKS89_16860	COG2723	6-phospho-beta-galactosidase activity
MKS89_16875	COG2095	MarC family integral membrane protein
MKS89_16900	COG0534	Mate efflux family protein
MKS89_16910	COG1151	hydroxylamine reductase activity
MKS89_16930	COG5002	protein histidine kinase activity
MKS89_16930	COG2205	protein histidine kinase activity
MKS89_16930	COG0784	Response regulator, receiver
MKS89_16940	COG1765	OsmC-like protein
MKS89_16950	COG2354	Protein conserved in bacteria
MKS89_16955	COG2226	methyltransferase
MKS89_16970	COG2204	response regulator
MKS89_17080	COG0418	dihydroorotase activity
MKS89_17120	COG0646	methionine synthase
MKS89_17120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MKS89_17160	COG0778	Nitroreductase
MKS89_17165	COG0583	DNA-binding transcription factor activity
MKS89_17200	COG0497	DNA recombination
MKS89_17215	COG0189	ligase activity
MKS89_17215	COG0569	domain protein
MKS89_17230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MKS89_17235	COG0363	glucosamine-6-phosphate deaminase activity
MKS89_17240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MKS89_17245	COG0784	Response regulator, receiver
MKS89_17245	COG3437	response regulator, receiver
MKS89_17250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MKS89_17260	COG2991	Protein conserved in bacteria
MKS89_17265	COG0673	inositol 2-dehydrogenase activity
MKS89_17280	COG1064	alcohol dehydrogenase
MKS89_17285	COG4305	rare lipoprotein A
MKS89_17300	COG1012	belongs to the aldehyde dehydrogenase family
MKS89_17305	COG3724	N-succinylarginine dihydrolase activity
MKS89_17310	COG2988	succinylglutamate desuccinylase activity
MKS89_17320	COG4191	Histidine kinase
MKS89_17355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKS89_17365	COG0156	8-amino-7-oxononanoate synthase activity
MKS89_17370	COG0784	Response regulator, receiver
MKS89_17370	COG2205	protein histidine kinase activity
MKS89_17375	COG3501	Rhs element vgr protein
MKS89_17375	COG3409	Peptidoglycan-binding domain 1 protein
MKS89_17405	COG1953	Uracil, thiamine, allantoin
MKS89_17410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKS89_17415	COG0765	amino acid transport
MKS89_17420	COG0765	amino acid transport
MKS89_17425	COG1126	abc transporter atp-binding protein
MKS89_17430	COG1737	Transcriptional regulator
MKS89_17450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MKS89_17480	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
MKS89_17485	COG2944	sequence-specific DNA binding
MKS89_17500	COG0531	amino acid
MKS89_17505	COG2957	Belongs to the agmatine deiminase family
MKS89_17510	COG3250	beta-galactosidase activity
MKS89_17520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKS89_17525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKS89_17530	COG1447	Phosphotransferase system cellobiose-specific component IIA
MKS89_17535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_17535	COG3711	transcriptional antiterminator
MKS89_17540	COG1979	alcohol dehydrogenase
MKS89_17550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKS89_17560	COG2855	membrane
MKS89_17580	COG2873	o-acetylhomoserine
MKS89_17585	COG1357	PFAM Pentapeptide repeats (8 copies)
MKS89_17595	COG0840	transmembrane signaling receptor activity
MKS89_17610	COG2115	Belongs to the xylose isomerase family
MKS89_17615	COG0477	Major facilitator Superfamily
MKS89_17615	COG2814	Major facilitator Superfamily
MKS89_17620	COG2207	Transcriptional regulator
MKS89_17620	COG1609	Transcriptional regulator
MKS89_17625	COG1070	Carbohydrate kinase
MKS89_17630	COG3104	oligopeptide transport
MKS89_17635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MKS89_17655	COG4251	negative regulation of phosphorylation
MKS89_17665	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKS89_17665	COG1902	pentaerythritol trinitrate reductase activity
MKS89_17680	COG1929	Belongs to the glycerate kinase type-1 family
MKS89_17690	COG3693	PFAM glycoside hydrolase, family 10
MKS89_17695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_17695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_17695	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MKS89_17700	COG1105	Belongs to the carbohydrate kinase PfkB family
MKS89_17710	COG1609	Transcriptional regulator
MKS89_17730	COG0642	Histidine kinase
MKS89_17740	COG2828	Protein conserved in bacteria
MKS89_17790	COG1203	CRISPR-associated helicase, Cas3
MKS89_17820	COG1518	maintenance of DNA repeat elements
MKS89_17825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MKS89_17840	COG3409	Peptidoglycan-binding domain 1 protein
MKS89_17840	COG3757	hydrolase, family 25
MKS89_17850	COG1869	D-ribose catabolic process
MKS89_17855	COG1129	ABC transporter
MKS89_17860	COG1172	Belongs to the binding-protein-dependent transport system permease family
MKS89_17865	COG1879	ABC-type sugar transport system periplasmic component
MKS89_17870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_17875	COG1609	Transcriptional regulator
MKS89_17880	COG2985	domain, Protein
MKS89_17885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKS89_17890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKS89_17895	COG1121	(ABC) transporter
MKS89_17910	COG1522	sequence-specific DNA binding
MKS89_17915	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MKS89_17920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MKS89_18065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MKS89_18070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MKS89_18075	COG2814	Major facilitator Superfamily
MKS89_18085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKS89_18090	COG0545	Peptidyl-prolyl cis-trans isomerase
MKS89_18100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKS89_18115	COG2897	thiosulfate sulfurtransferase activity
MKS89_18120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKS89_18130	COG0302	gtp cyclohydrolase
MKS89_18140	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MKS89_18150	COG1011	Hydrolase
MKS89_18165	COG1051	belongs to the nudix hydrolase family
MKS89_18170	COG4166	transmembrane transport
MKS89_18175	COG4174	ABC transporter (Permease)
MKS89_18180	COG4239	(ABC) transporter, permease
MKS89_18185	COG4172	Belongs to the ABC transporter superfamily
MKS89_18200	COG3038	cytochrome b561
MKS89_18205	COG2353	YceI-like domain
MKS89_18215	COG0583	DNA-binding transcription factor activity
MKS89_18220	COG3593	DNA synthesis involved in DNA repair
MKS89_18225	COG0737	Belongs to the 5'-nucleotidase family
MKS89_18235	COG2824	Alkylphosphonate utilization operon protein PhnA
MKS89_18240	COG2050	protein possibly involved in aromatic compounds catabolism
MKS89_18245	COG4533	DNA binding
MKS89_18250	COG0583	DNA-binding transcription factor activity
MKS89_18255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKS89_18255	COG0045	succinate-CoA ligase (ADP-forming) activity
MKS89_18255	COG1042	CoA-binding domain protein
MKS89_18280	COG0023	Translation Initiation Factor
MKS89_18310	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MKS89_18315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MKS89_18330	COG3706	GGDEF domain
MKS89_18355	COG1960	acyl-CoA dehydrogenase activity
MKS89_18370	COG3964	amidohydrolase
MKS89_18375	COG0471	metal ion transport
MKS89_18380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKS89_18385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKS89_18405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MKS89_18405	COG1918	ferrous iron import across plasma membrane
MKS89_18425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MKS89_18460	COG3845	ABC transporter
MKS89_18465	COG4603	Belongs to the binding-protein-dependent transport system permease family
MKS89_18470	COG1079	Belongs to the binding-protein-dependent transport system permease family
MKS89_18500	COG2351	hydroxyisourate hydrolase activity
MKS89_18505	COG0402	S-adenosylhomocysteine deaminase activity
MKS89_18515	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKS89_18540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKS89_18550	COG1538	Outer membrane efflux protein
MKS89_18565	COG0602	queuosine metabolic process
MKS89_18570	COG1328	CTP reductase activity
MKS89_18585	COG0640	Transcriptional regulator
MKS89_18600	COG2188	Transcriptional regulator
MKS89_18605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKS89_18610	COG1397	ADP-ribosylglycohydrolase
MKS89_18615	COG2211	Major facilitator Superfamily
MKS89_18620	COG1063	alcohol dehydrogenase
MKS89_18630	COG3634	alkyl hydroperoxide reductase activity
MKS89_18645	COG0243	molybdopterin cofactor binding
MKS89_18660	COG0513	Belongs to the DEAD box helicase family
MKS89_18665	COG0513	Belongs to the DEAD box helicase family
MKS89_18670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKS89_18670	COG3153	acetyltransferase
MKS89_18675	COG3507	Belongs to the glycosyl hydrolase 43 family
MKS89_18685	COG2200	EAL domain
MKS89_18700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MKS89_18705	COG0488	(ABC) transporter
MKS89_18725	COG2801	Transposase and inactivated derivatives
MKS89_18730	COG2842	Transposition protein
MKS89_18840	COG0640	Transcriptional regulator
MKS89_18855	COG4373	Mu-like prophage FluMu protein gp28
MKS89_18860	COG4383	Mu-like prophage protein gp29
MKS89_18875	COG4397	Mu-like prophage major head subunit gpT
MKS89_18915	COG4386	tail sheath protein
MKS89_18925	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
MKS89_18960	COG3778	Protein conserved in bacteria
MKS89_18990	COG2723	6-phospho-beta-galactosidase activity
MKS89_18995	COG0840	transmembrane signaling receptor activity
MKS89_19000	COG0513	Belongs to the DEAD box helicase family
MKS89_19005	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MKS89_19015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MKS89_19025	COG0523	cobalamin synthesis protein
MKS89_19030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MKS89_19045	COG0183	Belongs to the thiolase family
MKS89_19060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MKS89_19070	COG1803	Methylglyoxal synthase
MKS89_19075	COG0210	DNA helicase
MKS89_19080	COG1289	transmembrane transporter activity
MKS89_19095	COG1492	cobalamin metabolic process
MKS89_19105	COG5002	protein histidine kinase activity
MKS89_19105	COG0784	Response regulator, receiver
MKS89_19120	COG2827	Endonuclease containing a URI domain
MKS89_19125	COG3132	Protein of unknown function, DUF480
MKS89_19135	COG0678	peroxiredoxin activity
MKS89_19140	COG0494	nUDIX hydrolase
MKS89_19170	COG0625	glutathione transferase activity
MKS89_19175	COG1584	GPR1 FUN34 yaaH family protein
MKS89_19180	COG3713	MltA-interacting MipA family protein
MKS89_19185	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MKS89_19205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKS89_19210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKS89_19230	COG2273	Hydrolase Family 16
MKS89_19230	COG5297	Belongs to the glycosyl hydrolase family 6
MKS89_19250	COG2095	MarC family integral membrane protein
MKS89_19260	COG4181	ATPase activity
MKS89_19270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MKS89_19305	COG2273	Hydrolase Family 16
MKS89_19305	COG5297	Belongs to the glycosyl hydrolase family 6
MKS89_19310	COG1609	Transcriptional regulator
MKS89_19320	COG3459	Glycosyltransferase 36 associated
MKS89_19325	COG3842	ATPase activity
MKS89_19330	COG2723	6-phospho-beta-galactosidase activity
MKS89_19350	COG1609	Transcriptional regulator
MKS89_19355	COG0840	transmembrane signaling receptor activity
MKS89_19360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MKS89_19375	COG5001	Diguanylate cyclase
MKS89_19375	COG3300	MHYT domain
MKS89_19385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MKS89_19395	COG0509	glycine decarboxylation via glycine cleavage system
MKS89_19400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKS89_19400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MKS89_19440	COG0419	ATPase involved in DNA repair
MKS89_19460	COG0419	ATPase involved in DNA repair
MKS89_19475	COG0454	-acetyltransferase
MKS89_19520	COG1518	maintenance of DNA repeat elements
MKS89_19520	COG1468	defense response to virus
MKS89_19525	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MKS89_19530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKS89_19535	COG0659	secondary active sulfate transmembrane transporter activity
MKS89_19580	COG2017	converts alpha-aldose to the beta-anomer
MKS89_19600	COG1566	PFAM secretion protein HlyD family protein
MKS89_19605	COG1289	transmembrane transporter activity
MKS89_19625	COG2211	Major facilitator Superfamily
MKS89_19630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MKS89_19640	COG3477	response to acidic pH
MKS89_19645	COG1012	belongs to the aldehyde dehydrogenase family
MKS89_19650	COG3284	Transcriptional regulator
MKS89_19665	COG1349	DNA-binding transcription factor activity
MKS89_19670	COG0584	glycerophosphoryl diester phosphodiesterase
MKS89_19680	COG1175	transmembrane transport
MKS89_19685	COG0395	ABC-type sugar transport system, permease component
MKS89_19690	COG3842	ATPase activity
MKS89_19700	COG0681	Belongs to the peptidase S26 family
MKS89_19750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKS89_19755	COG0242	peptide deformylase activity
MKS89_19760	COG4115	mRNA cleavage
MKS89_19765	COG2161	toxin-antitoxin pair type II binding
MKS89_19790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKS89_19795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKS89_19805	COG0251	oxidation-reduction process
MKS89_19810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MKS89_19830	COG3335	DDE superfamily endonuclease
MKS89_19880	COG1942	4-Oxalocrotonate Tautomerase
MKS89_19915	COG1349	DNA-binding transcription factor activity
MKS89_19920	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_19925	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_19930	COG3731	PTS system glucitol sorbitol-specific IIA component
MKS89_19940	COG3730	PTS system glucitol sorbitol-specific
MKS89_19975	COG0076	glutamate decarboxylase activity
MKS89_19980	COG2207	Transcriptional regulator
MKS89_19990	COG0747	negative chemotaxis
MKS89_19995	COG0601	transmembrane transport
MKS89_20000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKS89_20005	COG0444	Belongs to the ABC transporter superfamily
MKS89_20010	COG4608	Belongs to the ABC transporter superfamily
MKS89_20020	COG1028	Short-chain dehydrogenase reductase Sdr
MKS89_20030	COG1278	Cold shock
MKS89_20045	COG2194	sulfuric ester hydrolase activity
MKS89_20110	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MKS89_20155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MKS89_20195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MKS89_20200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_20205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_20210	COG1120	ATPase activity
MKS89_20230	COG0384	phenazine biosynthesis protein PhzF
MKS89_20255	COG0549	Belongs to the carbamate kinase family
MKS89_20260	COG0531	amino acid
MKS89_20265	COG2957	Belongs to the agmatine deiminase family
MKS89_20275	COG2814	Major facilitator Superfamily
MKS89_20280	COG0583	DNA-binding transcription factor activity
MKS89_20285	COG1309	transcriptional regulator
MKS89_20290	COG0531	amino acid
MKS89_20310	COG0318	PFAM AMP-dependent synthetase and ligase
MKS89_20310	COG0204	Acyl-transferase
MKS89_20330	COG3210	domain, Protein
MKS89_20330	COG3210	domain, Protein
MKS89_20335	COG2831	hemolysin activation secretion protein
MKS89_20350	COG4773	Receptor
MKS89_20355	COG2207	Transcriptional regulator
MKS89_20375	COG0346	lactoylglutathione lyase activity
MKS89_20385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKS89_20410	COG0471	metal ion transport
MKS89_20420	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MKS89_20430	COG0583	DNA-binding transcription factor activity
MKS89_20435	COG1620	l-lactate permease
MKS89_20445	COG1139	Iron-sulfur cluster binding protein
MKS89_20460	COG1605	Chorismate mutase
MKS89_20485	COG1518	maintenance of DNA repeat elements
MKS89_20485	COG1468	defense response to virus
MKS89_20530	COG4948	Mandelate Racemase Muconate Lactonizing
MKS89_20535	COG2186	Transcriptional regulator
MKS89_20540	COG1063	alcohol dehydrogenase
MKS89_20545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKS89_20580	COG3829	transcription factor binding
MKS89_20645	COG0840	transmembrane signaling receptor activity
MKS89_20650	COG1609	Transcriptional regulator
MKS89_20660	COG0247	lactate metabolic process
MKS89_20665	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
MKS89_20670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MKS89_20675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MKS89_20685	COG1120	ATPase activity
MKS89_20690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_20695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKS89_20700	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MKS89_20750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MKS89_20750	COG0456	acetyltransferase
MKS89_20805	COG3693	PFAM glycoside hydrolase, family 10
MKS89_20805	COG3509	depolymerase
MKS89_20815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKS89_20820	COG1794	racemase activity, acting on amino acids and derivatives
MKS89_20835	COG3711	transcriptional antiterminator
MKS89_20840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_20845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKS89_20845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_20845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_20850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_20850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKS89_20850	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MKS89_20855	COG0191	fructose-bisphosphate aldolase activity
MKS89_20860	COG0191	fructose-bisphosphate aldolase activity
MKS89_20865	COG1940	carbohydrate kinase activity
MKS89_20870	COG3384	dioxygenase
MKS89_20875	COG0583	DNA-binding transcription factor activity
MKS89_20890	COG2272	Belongs to the type-B carboxylesterase lipase family