locus-tag	class	description
LA59_00025	COG1982	Orn Lys Arg decarboxylase major
LA59_00030	COG0531	amino acid
LA59_00040	COG3710	Transcriptional regulator
LA59_00045	COG0789	Transcriptional regulator
LA59_00060	COG0151	Belongs to the GarS family
LA59_00075	COG1253	flavin adenine dinucleotide binding
LA59_00080	COG3068	Protein conserved in bacteria
LA59_00090	COG1573	uracil-dna glycosylase
LA59_00110	COG2816	NAD+ diphosphatase activity
LA59_00115	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LA59_00135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LA59_00150	COG0250	Participates in transcription elongation, termination and antitermination
LA59_00155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA59_00195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LA59_00205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA59_00315	COG0534	Mate efflux family protein
LA59_00330	COG2937	Belongs to the GPAT DAPAT family
LA59_00340	COG3161	chorismate lyase activity
LA59_00345	COG1580	Controls the rotational direction of flagella during chemotaxis
LA59_00350	COG0705	Rhomboid family
LA59_00365	COG2177	Part of the ABC transporter FtsEX involved in
LA59_00370	COG2884	Cell division ATP-binding protein ftsE
LA59_00375	COG0552	protein localization to endoplasmic reticulum
LA59_00380	COG0742	ribosomal rna small subunit methyltransferase
LA59_00390	COG2095	MarC family integral membrane protein
LA59_00435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA59_00440	COG0640	Transcriptional regulator
LA59_00445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LA59_00450	COG1280	lysine exporter protein (LysE YggA)
LA59_00455	COG2267	carboxylic ester hydrolase activity
LA59_00480	COG3287	FIST C domain
LA59_00480	COG2200	EAL domain
LA59_00480	COG2199	diguanylate cyclase activity
LA59_00485	COG1011	Hydrolase
LA59_00505	COG0019	diaminopimelate decarboxylase activity
LA59_00520	COG3072	Adenylate cyclase
LA59_00530	COG1587	Uroporphyrinogen-III synthase
LA59_00535	COG2959	enzyme of heme biosynthesis
LA59_00540	COG3071	HemY protein
LA59_00580	COG0633	Ferredoxin
LA59_00585	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LA59_00595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LA59_00600	COG3118	belongs to the thioredoxin family
LA59_00615	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LA59_00625	COG0514	ATP-dependent DNA helicase (RecQ)
LA59_00630	COG2962	Rard protein
LA59_00640	COG1280	lysine exporter protein (LysE YggA)
LA59_00645	COG0405	Gamma-glutamyltransferase
LA59_00650	COG0210	DNA helicase
LA59_00660	COG3220	belongs to the UPF0276 family
LA59_00680	COG2814	Major facilitator Superfamily
LA59_00690	COG0006	proline dipeptidase activity
LA59_00690	COG0006	proline dipeptidase activity
LA59_00705	COG2104	thiamine diphosphate biosynthetic process
LA59_00710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA59_00730	COG2132	Multicopper oxidase
LA59_00770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LA59_00780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LA59_00795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LA59_00800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LA59_00805	COG0551	DNA topoisomerase type I activity
LA59_00815	COG0758	DNA mediated transformation
LA59_00835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA59_00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA59_00840	COG0569	domain protein
LA59_00845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA59_00855	COG1272	protein, Hemolysin III
LA59_00860	COG4326	sporulation control protein
LA59_00865	COG3084	Protein conserved in bacteria
LA59_00875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LA59_00880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA59_00895	COG3706	GGDEF domain
LA59_00900	COG0606	chelatase, subunit chli
LA59_00910	COG3978	acetolactate synthase activity
LA59_00915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LA59_00920	COG0129	dihydroxy-acid dehydratase activity
LA59_00930	COG0583	DNA-binding transcription factor activity
LA59_00935	COG2814	Major facilitator Superfamily
LA59_00945	COG0765	amino acid transport
LA59_00955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LA59_00965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LA59_00990	COG0356	it plays a direct role in the translocation of protons across the membrane
LA59_00995	COG3312	ion transport
LA59_01000	COG1475	DNA binding
LA59_01005	COG1192	Involved in chromosome partitioning
LA59_01015	COG0445	tRNA wobble uridine modification
LA59_01020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA59_01045	COG1126	abc transporter atp-binding protein
LA59_01065	COG0592	DNA-directed DNA polymerase activity
LA59_01075	COG0187	DNA topoisomerase II activity
LA59_01080	COG0071	Belongs to the small heat shock protein (HSP20) family
LA59_01085	COG3977	Valine--pyruvate aminotransferase
LA59_01090	COG0366	Alpha amylase catalytic
LA59_01105	COG2119	membrane
LA59_01115	COG0425	Belongs to the sulfur carrier protein TusA family
LA59_01130	COG0604	alcohol dehydrogenase
LA59_01135	COG0183	Belongs to the thiolase family
LA59_01145	COG1739	Uncharacterized protein family UPF0029
LA59_01150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA59_01200	COG0583	DNA-binding transcription factor activity
LA59_01205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LA59_01210	COG2960	long-chain fatty acid transporting porin activity
LA59_01215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_01220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_01225	COG1309	transcriptional regulator
LA59_01275	COG4172	Belongs to the ABC transporter superfamily
LA59_01280	COG0747	negative chemotaxis
LA59_01290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_01325	COG1609	Transcriptional regulator
LA59_01330	COG0583	DNA-binding transcription factor activity
LA59_01335	COG2076	Multidrug Resistance protein
LA59_01340	COG2076	Multidrug Resistance protein
LA59_01350	COG0129	dihydroxy-acid dehydratase activity
LA59_01355	COG3265	gluconokinase activity
LA59_01360	COG2610	gluconate transmembrane transporter activity
LA59_01365	COG0800	Aldolase
LA59_01370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_01380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LA59_01390	COG1522	sequence-specific DNA binding
LA59_01395	COG5002	protein histidine kinase activity
LA59_01395	COG5001	Diguanylate cyclase
LA59_01410	COG0697	spore germination
LA59_01415	COG0589	response to stress
LA59_01420	COG1528	Iron-storage protein
LA59_01430	COG2081	HI0933 family
LA59_01450	COG1322	Protein conserved in bacteria
LA59_01460	COG3165	ubiquinone biosynthetic process from chorismate
LA59_01480	COG0805	protein transport
LA59_01485	COG0084	hydrolase, TatD family'
LA59_01500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA59_01500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA59_01505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LA59_01530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA59_01535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LA59_01545	COG2204	response regulator
LA59_01550	COG3852	Histidine kinase
LA59_01560	COG0174	glutamine synthetase
LA59_01585	COG1490	D-aminoacyl-tRNA deacylase activity
LA59_01590	COG0456	acetyltransferase
LA59_01610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LA59_01615	COG3031	protein transport across the cell outer membrane
LA59_01625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA59_01630	COG1459	type II secretion system
LA59_01635	COG2165	general secretion pathway protein
LA59_01640	COG2165	general secretion pathway protein
LA59_01645	COG2165	general secretion pathway protein
LA59_01650	COG4795	General secretion pathway protein
LA59_01655	COG3156	type II secretion system protein K
LA59_01660	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LA59_01665	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LA59_01675	COG1218	3'(2'),5'-bisphosphate nucleotidase
LA59_01680	COG0494	nUDIX hydrolase
LA59_01690	COG1040	competence protein
LA59_01705	COG2183	response to ionizing radiation
LA59_01715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA59_01720	COG0745	RESPONSE REGULATOR receiver
LA59_01725	COG2205	protein histidine kinase activity
LA59_01730	COG2233	PERMEase
LA59_01740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA59_01745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA59_01750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA59_01755	COG1758	RNA polymerase activity
LA59_01760	COG0194	GDP metabolic process
LA59_01775	COG0848	biopolymer transport protein
LA59_01780	COG0811	peptide transport
LA59_01800	COG4174	ABC transporter (Permease)
LA59_01805	COG4239	(ABC) transporter, permease
LA59_01810	COG0747	negative chemotaxis
LA59_01845	COG0745	RESPONSE REGULATOR receiver
LA59_01850	COG1561	YicC-like family, N-terminal region
LA59_01855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LA59_01865	COG1560	Kdo2-lipid A biosynthetic process
LA59_01875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA59_01900	COG2194	sulfuric ester hydrolase activity
LA59_01915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LA59_01930	COG0463	Glycosyl transferase, family 2
LA59_01935	COG0859	PFAM glycosyl transferase family 9
LA59_01940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LA59_01945	COG3642	lipopolysaccharide core region biosynthetic process
LA59_01970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA59_01985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA59_01990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LA59_01995	COG2089	acid synthase
LA59_02005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LA59_02020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LA59_02030	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_02045	COG1519	Transferase
LA59_02050	COG0859	PFAM glycosyl transferase family 9
LA59_02055	COG1560	Kdo2-lipid A biosynthetic process
LA59_02065	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_02110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LA59_02125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA59_02135	COG0463	Glycosyl transferase, family 2
LA59_02150	COG0438	transferase activity, transferring glycosyl groups
LA59_02160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LA59_02165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LA59_02170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LA59_02170	COG0517	IMP dehydrogenase activity
LA59_02175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LA59_02195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LA59_02200	COG0149	triose-phosphate isomerase activity
LA59_02225	COG1494	fructose-1,6-bisphosphatase
LA59_02235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA59_02240	COG1575	Belongs to the MenA family. Type 1 subfamily
LA59_02260	COG1609	Transcriptional regulator
LA59_02265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA59_02270	COG0254	rRNA binding
LA59_02285	COG0088	Forms part of the polypeptide exit tunnel
LA59_02305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LA59_02355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LA59_02370	COG1841	ribosomal large subunit assembly
LA59_02375	COG0200	Binds to the 23S rRNA
LA59_02380	COG0201	protein transport
LA59_02390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LA59_02395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LA59_02405	COG0202	RNA polymerase activity
LA59_02410	COG0203	ribosomal protein L17
LA59_02420	COG0545	Peptidyl-prolyl cis-trans isomerase
LA59_02435	COG2153	protein acetylation
LA59_02440	COG0513	Belongs to the DEAD box helicase family
LA59_02450	COG0737	Belongs to the 5'-nucleotidase family
LA59_02455	COG1648	precorrin-2 dehydrogenase activity
LA59_02455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LA59_02470	COG3273	potassium ion transport
LA59_02470	COG0471	metal ion transport
LA59_02475	COG0529	Catalyzes the synthesis of activated sulfate
LA59_02495	COG1136	(ABC) transporter
LA59_02505	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LA59_02515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA59_02520	COG0729	surface antigen
LA59_02525	COG2911	Protein conserved in bacteria
LA59_02530	COG2105	PFAM AIG2 family protein
LA59_02540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LA59_02550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA59_02555	COG0163	prenyltransferase activity
LA59_02560	COG4143	(ABC) transporter
LA59_02565	COG1178	ABC-type Fe3 transport system permease component
LA59_02570	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LA59_02605	COG3385	transposase activity
LA59_02610	COG0142	geranyltranstransferase activity
LA59_02615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LA59_02625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LA59_02630	COG2966	Psort location CytoplasmicMembrane, score
LA59_02635	COG3610	response to peptide
LA59_02655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LA59_02660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LA59_02665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA59_02670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LA59_02675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LA59_02695	COG0473	3-isopropylmalate dehydrogenase activity
LA59_02700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LA59_02710	COG0671	phosphoesterase, PA-phosphatase related
LA59_02720	COG0583	DNA-binding transcription factor activity
LA59_02725	COG1022	Amp-dependent synthetase and ligase
LA59_02730	COG0028	Belongs to the TPP enzyme family
LA59_02735	COG0440	acetolactate synthase activity
LA59_02740	COG3706	GGDEF domain
LA59_02750	COG0469	pyruvate kinase activity
LA59_02755	COG1349	DNA-binding transcription factor activity
LA59_02760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LA59_02780	COG5002	protein histidine kinase activity
LA59_02785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA59_02790	COG3722	fumarate hydratase activity
LA59_02800	COG2213	PTS system mannitol-specific
LA59_02800	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_02830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA59_02835	COG0358	DNA primase activity
LA59_02840	COG1610	YqeY-like protein
LA59_02845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LA59_02850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LA59_02855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA59_02865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LA59_02870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA59_02885	COG3267	Type II secretory pathway component ExeA
LA59_02885	COG3409	Peptidoglycan-binding domain 1 protein
LA59_02895	COG4991	sh3 domain protein
LA59_02900	COG0306	phosphate transporter
LA59_02905	COG1392	Phosphate transport regulator
LA59_02910	COG3025	triphosphatase activity
LA59_02915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA59_02925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LA59_02935	COG1538	Outer membrane efflux protein
LA59_02940	COG0494	nUDIX hydrolase
LA59_02945	COG3151	Protein conserved in bacteria
LA59_02955	COG3150	esterase
LA59_02960	COG0187	DNA topoisomerase II activity
LA59_02965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LA59_02970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA59_02985	COG3105	Protein conserved in bacteria
LA59_02990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LA59_03005	COG0723	plastoquinol--plastocyanin reductase activity
LA59_03010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LA59_03015	COG2857	Cytochrome c1
LA59_03020	COG0625	glutathione transferase activity
LA59_03025	COG2969	positive regulation of protein catabolic process
LA59_03030	COG2823	Periplasmic or secreted lipoprotein
LA59_03035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LA59_03050	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LA59_03060	COG3116	cell division
LA59_03065	COG0768	penicillin binding
LA59_03070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LA59_03075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA59_03090	COG0772	Belongs to the SEDS family
LA59_03105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LA59_03110	COG0849	cell division
LA59_03115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LA59_03130	COG0494	nUDIX hydrolase
LA59_03140	COG0505	Belongs to the CarA family
LA59_03145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LA59_03165	COG0730	response to heat
LA59_03170	COG0583	DNA-binding transcription factor activity
LA59_03175	COG2860	membrane
LA59_03200	COG0493	'glutamate synthase
LA59_03205	COG0069	glutamate synthase activity
LA59_03205	COG0070	glutamate synthase
LA59_03205	COG0067	glutamate synthase
LA59_03215	COG0070	glutamate synthase
LA59_03215	COG0067	glutamate synthase
LA59_03215	COG0069	glutamate synthase activity
LA59_03220	COG1242	4 iron, 4 sulfur cluster binding
LA59_03225	COG5001	Diguanylate cyclase
LA59_03225	COG2203	Gaf domain
LA59_03225	COG4251	negative regulation of phosphorylation
LA59_03225	COG3706	GGDEF domain
LA59_03235	COG0784	Response regulator, receiver
LA59_03235	COG2198	Histidine kinase
LA59_03235	COG5002	protein histidine kinase activity
LA59_03245	COG0745	RESPONSE REGULATOR receiver
LA59_03255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LA59_03270	COG0083	homoserine kinase activity
LA59_03275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LA59_03280	COG0431	NADPH-dependent FMN reductase
LA59_03310	COG1115	amino acid carrier protein
LA59_03315	COG3022	response to hydroperoxide
LA59_03325	COG0513	Belongs to the DEAD box helicase family
LA59_03340	COG0716	FMN binding
LA59_03350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA59_03355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LA59_03360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LA59_03375	COG3385	transposase activity
LA59_03385	COG0667	Aldo Keto reductase
LA59_03405	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
LA59_03410	COG0730	response to heat
LA59_03425	COG1283	sodium-dependent phosphate transmembrane transporter activity
LA59_03430	COG0583	DNA-binding transcription factor activity
LA59_03435	COG0640	Transcriptional regulator
LA59_03440	COG0268	Binds directly to 16S ribosomal RNA
LA59_03445	COG0728	peptidoglycan biosynthetic process
LA59_03450	COG0196	riboflavin kinase activity
LA59_03465	COG1047	Peptidyl-prolyl cis-trans
LA59_03470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LA59_03475	COG3279	Response regulator of the LytR AlgR family
LA59_03480	COG3275	phosphorelay sensor kinase activity
LA59_03485	COG1966	Carbon starvation protein
LA59_03500	COG3385	transposase activity
LA59_03510	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LA59_03515	COG1472	Belongs to the glycosyl hydrolase 3 family
LA59_03520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA59_03525	COG0287	Prephenate dehydrogenase
LA59_03525	COG1605	Chorismate mutase
LA59_03530	COG0739	heme binding
LA59_03540	COG0488	(ABC) transporter
LA59_03555	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LA59_03560	COG0077	Prephenate dehydratase
LA59_03560	COG1605	Chorismate mutase
LA59_03565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LA59_03570	COG0741	lytic transglycosylase activity
LA59_03575	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_03580	COG0564	pseudouridine synthase activity
LA59_03590	COG0542	response to heat
LA59_03645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA59_03660	COG0745	RESPONSE REGULATOR receiver
LA59_03665	COG5002	protein histidine kinase activity
LA59_03675	COG0248	Ppx GppA phosphatase
LA59_03680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LA59_03685	COG0573	inorganic phosphate transmembrane transporter activity
LA59_03690	COG0581	inorganic phosphate transmembrane transporter activity
LA59_03695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA59_03700	COG0704	Plays a role in the regulation of phosphate uptake
LA59_03730	COG0450	alkyl hydroperoxide reductase
LA59_03735	COG0583	DNA-binding transcription factor activity
LA59_03740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LA59_03750	COG0517	IMP dehydrogenase activity
LA59_03775	COG1862	Preprotein translocase
LA59_03780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_03785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_03800	COG0483	inositol monophosphate 1-phosphatase activity
LA59_03805	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LA59_03820	COG0822	iron-sulfur transferase activity
LA59_03825	COG0316	Belongs to the HesB IscA family
LA59_03840	COG0633	Ferredoxin
LA59_03845	COG2975	iron-sulfur cluster assembly
LA59_03880	COG2976	Protein conserved in bacteria
LA59_03885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_03900	COG2199	diguanylate cyclase activity
LA59_03900	COG2203	Gaf domain
LA59_03910	COG0517	IMP dehydrogenase activity
LA59_03910	COG0516	GMP reductase activity
LA59_03920	COG1757	Na H antiporter
LA59_03930	COG1584	GPR1 FUN34 yaaH family protein
LA59_03935	COG1115	amino acid carrier protein
LA59_03945	COG0583	DNA-binding transcription factor activity
LA59_03960	COG2873	o-acetylhomoserine
LA59_03970	COG0316	Belongs to the HesB IscA family
LA59_03975	COG0719	Fe-S assembly protein
LA59_03980	COG0396	ATPase activity
LA59_03985	COG0719	Fe-S assembly protein
LA59_04005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA59_04025	COG1289	transmembrane transporter activity
LA59_04030	COG0583	DNA-binding transcription factor activity
LA59_04060	COG0582	viral genome integration into host DNA
LA59_04070	COG2867	negative regulation of translational initiation
LA59_04075	COG2914	Belongs to the UPF0125 (RnfH) family
LA59_04080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LA59_04085	COG0497	DNA recombination
LA59_04105	COG1301	dicarboxylic acid transport
LA59_04145	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LA59_04150	COG0590	tRNA wobble adenosine to inosine editing
LA59_04160	COG0047	phosphoribosylformylglycinamidine synthase activity
LA59_04160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LA59_04190	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA59_04195	COG2252	PERMEase
LA59_04200	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LA59_04220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LA59_04225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LA59_04230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA59_04230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA59_04255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA59_04260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LA59_04270	COG0142	geranyltranstransferase activity
LA59_04280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA59_04295	COG0583	DNA-binding transcription factor activity
LA59_04305	COG2363	Small membrane protein
LA59_04325	COG1611	Belongs to the LOG family
LA59_04330	COG3706	GGDEF domain
LA59_04350	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LA59_04355	COG0737	Belongs to the 5'-nucleotidase family
LA59_04365	COG1464	Belongs to the NlpA lipoprotein family
LA59_04370	COG2011	ABC-type metal ion transport system permease component
LA59_04375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LA59_04380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA59_04390	COG1263	PTS System
LA59_04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_04395	COG0366	Alpha amylase catalytic
LA59_04410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LA59_04415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LA59_04435	COG1686	Belongs to the peptidase S11 family
LA59_04440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LA59_04445	COG0772	Belongs to the SEDS family
LA59_04450	COG0768	penicillin binding
LA59_04460	COG0799	negative regulation of ribosome biogenesis
LA59_04465	COG1466	dna polymerase III delta subunit
LA59_04470	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LA59_04480	COG2888	peptidyl-tyrosine sulfation
LA59_04485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LA59_04490	COG4535	Mg2 and Co2 transporter CorC
LA59_04500	COG1702	phosphate starvation-inducible protein PhoH
LA59_04510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA59_04630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LA59_04655	COG2890	protein-(glutamine-N5) methyltransferase activity
LA59_04660	COG3094	Invasion gene expression up-regulator, SirB
LA59_04665	COG2912	Transglutaminase-like superfamily
LA59_04670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LA59_04675	COG0737	Belongs to the 5'-nucleotidase family
LA59_04680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LA59_04685	COG1187	pseudouridine synthase activity
LA59_04690	COG2840	Smr protein MutS2
LA59_04735	COG2217	Heavy metal translocating P-type atpase
LA59_04735	COG2608	mercury ion transmembrane transporter activity
LA59_04745	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LA59_04800	COG0835	chemotaxis
LA59_04800	COG0784	Response regulator, receiver
LA59_04805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LA59_04810	COG1815	bacterial-type flagellum-dependent cell motility
LA59_04815	COG1558	bacterial-type flagellum-dependent cell motility
LA59_04820	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LA59_04825	COG1749	Flagellar hook protein flgE
LA59_04830	COG4787	bacterial-type flagellum-dependent cell motility
LA59_04835	COG4786	Flagellar basal body rod
LA59_04840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LA59_04845	COG1706	bacterial-type flagellum-dependent cell motility
LA59_04850	COG3951	Flagellar rod assembly protein muramidase FlgJ
LA59_04850	COG1705	Flagellar rod assembly protein muramidase FlgJ
LA59_04865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_04870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_04875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_04880	COG2190	(PTS) system
LA59_04885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA59_04890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_04895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LA59_04900	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LA59_04930	COG0330	HflC and HflK could
LA59_04935	COG3118	belongs to the thioredoxin family
LA59_04940	COG0300	oxidoreductase activity
LA59_04945	COG1090	epimerase
LA59_04975	COG0622	Phosphoesterase
LA59_04995	COG3710	Transcriptional regulator
LA59_05010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LA59_05015	COG3104	oligopeptide transport
LA59_05025	COG0367	asparagine synthase
LA59_05030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LA59_05030	COG4651	solute:proton antiporter activity
LA59_05035	COG1846	Transcriptional regulator
LA59_05035	COG1940	carbohydrate kinase activity
LA59_05040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LA59_05045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_05045	COG2190	(PTS) system
LA59_05045	COG1263	PTS System
LA59_05060	COG0735	belongs to the Fur family
LA59_05070	COG0716	FMN binding
LA59_05080	COG0596	Alpha beta hydrolase
LA59_05090	COG0033	Phosphoglucomutase
LA59_05105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LA59_05115	COG2009	succinate dehydrogenase
LA59_05120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LA59_05125	COG1053	succinate dehydrogenase
LA59_05135	COG0567	Dehydrogenase, E1 component
LA59_05140	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA59_05155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_05160	COG1121	(ABC) transporter
LA59_05165	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LA59_05170	COG4977	sequence-specific DNA binding
LA59_05175	COG1918	ferrous iron import across plasma membrane
LA59_05205	COG3102	Protein conserved in bacteria
LA59_05210	COG0788	formyltetrahydrofolate deformylase activity
LA59_05215	COG1199	ATP-dependent helicase activity
LA59_05220	COG1214	PFAM Peptidase M22, glycoprotease
LA59_05230	COG3065	identical protein binding
LA59_05235	COG2267	carboxylic ester hydrolase activity
LA59_05240	COG0318	PFAM AMP-dependent synthetase and ligase
LA59_05245	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LA59_05250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LA59_05255	COG2894	cell division
LA59_05270	COG2951	lytic endotransglycosylase activity
LA59_05280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA59_05315	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_05320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA59_05350	COG2986	histidine ammonia-lyase
LA59_05355	COG1216	Glycosyl transferase, family 2
LA59_05375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA59_05380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LA59_05410	COG2226	methyltransferase
LA59_05425	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_05435	COG1169	isochorismate synthase
LA59_05440	COG1021	2,3-dihydroxybenzoate-AMP ligase
LA59_05445	COG1535	isochorismatase
LA59_05445	COG3433	isochorismatase activity
LA59_05450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LA59_05450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LA59_05465	COG4771	TonB-dependent receptor
LA59_05470	COG1253	flavin adenine dinucleotide binding
LA59_05475	COG0513	Belongs to the DEAD box helicase family
LA59_05480	COG0569	domain protein
LA59_05485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LA59_05500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LA59_05505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LA59_05510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LA59_05525	COG4191	Histidine kinase
LA59_05545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LA59_05550	COG0776	regulation of translation
LA59_05555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA59_05660	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LA59_05670	COG0436	Aminotransferase
LA59_05675	COG1169	isochorismate synthase
LA59_05685	COG0596	Alpha beta hydrolase
LA59_05690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LA59_05695	COG1441	menaquinone biosynthetic process
LA59_05705	COG2190	(PTS) system
LA59_05705	COG1263	PTS System
LA59_05705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_05710	COG0583	DNA-binding transcription factor activity
LA59_05720	COG2855	membrane
LA59_05775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_05800	COG1522	sequence-specific DNA binding
LA59_05810	COG1946	Acyl-CoA thioesterase
LA59_05815	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LA59_05830	COG3706	GGDEF domain
LA59_05835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LA59_05840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA59_05845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LA59_05850	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LA59_05855	COG0516	GMP reductase activity
LA59_05855	COG0517	IMP dehydrogenase activity
LA59_05865	COG2217	Heavy metal translocating P-type atpase
LA59_05885	COG0537	adenosine 5'-monophosphoramidase activity
LA59_05915	COG1252	NADH dehydrogenase
LA59_05930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA59_05940	COG4591	ABC-type transport system involved in lipoprotein release permease component
LA59_05945	COG1136	(ABC) transporter
LA59_05950	COG4591	ABC-type transport system involved in lipoprotein release permease component
LA59_05965	COG1132	(ABC) transporter
LA59_05985	COG2719	SpoVR family
LA59_05990	COG2718	Belongs to the UPF0229 family
LA59_05995	COG2766	serine protein kinase
LA59_06010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA59_06020	COG1882	Formate acetyltransferase
LA59_06045	COG4215	(ABC) transporter
LA59_06055	COG0708	Exodeoxyribonuclease III
LA59_06060	COG0840	transmembrane signaling receptor activity
LA59_06075	COG0730	response to heat
LA59_06080	COG1199	ATP-dependent helicase activity
LA59_06090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LA59_06095	COG1187	pseudouridine synthase activity
LA59_06105	COG1278	Cold shock
LA59_06115	COG0542	response to heat
LA59_06120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LA59_06150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA59_06155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LA59_06160	COG0297	glycogen (starch) synthase activity
LA59_06180	COG3070	regulator of competence-specific genes
LA59_06195	COG0745	RESPONSE REGULATOR receiver
LA59_06200	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LA59_06205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA59_06215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LA59_06220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LA59_06235	COG4067	protein conserved in archaea
LA59_06235	COG0189	ligase activity
LA59_06250	COG1801	Protein of unknown function DUF72
LA59_06265	COG0840	transmembrane signaling receptor activity
LA59_06270	COG0632	four-way junction helicase activity
LA59_06280	COG1271	oxidase subunit
LA59_06285	COG1294	oxidase, subunit
LA59_06290	COG4890	Cyd operon protein YbgT
LA59_06300	COG0824	Thioesterase
LA59_06305	COG0811	peptide transport
LA59_06320	COG0823	Involved in the tonB-independent uptake of proteins
LA59_06325	COG2885	chlorophyll binding
LA59_06330	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LA59_06345	COG0673	inositol 2-dehydrogenase activity
LA59_06350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_06350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_06350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA59_06355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_06360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_06370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA59_06375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA59_06380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LA59_06385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_06390	COG2207	Transcriptional regulator
LA59_06395	COG0371	Dehydrogenase
LA59_06400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA59_06420	COG3766	membrane
LA59_06430	COG0754	glutathionylspermidine amidase activity
LA59_06440	COG5002	protein histidine kinase activity
LA59_06440	COG0784	Response regulator, receiver
LA59_06520	COG4669	(LipO)protein
LA59_06565	COG4792	protein secretion
LA59_06570	COG4791	protein targeting
LA59_06575	COG4794	Type iii secretion
LA59_06580	COG4790	Type iii secretion
LA59_06585	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LA59_06650	COG0457	Tetratricopeptide repeat
LA59_06665	COG0789	Transcriptional regulator
LA59_06670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LA59_06675	COG3385	transposase activity
LA59_06690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_06690	COG1263	PTS System
LA59_06695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_06700	COG1621	beta-fructofuranosidase activity
LA59_06705	COG2824	Alkylphosphonate utilization operon protein PhnA
LA59_06745	COG0534	Mate efflux family protein
LA59_06750	COG0444	Belongs to the ABC transporter superfamily
LA59_06755	COG4608	Belongs to the ABC transporter superfamily
LA59_06760	COG0747	negative chemotaxis
LA59_06795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_06800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_06810	COG2186	Transcriptional regulator
LA59_06820	COG1288	antiporter activity
LA59_06845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_06860	COG2176	DNA-directed DNA polymerase activity
LA59_06865	COG0517	IMP dehydrogenase activity
LA59_06870	COG2186	Transcriptional regulator
LA59_06875	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_06880	COG2186	Transcriptional regulator
LA59_06900	COG1917	Cupin 2, conserved barrel domain protein
LA59_06905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_06910	COG0800	Aldolase
LA59_06915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_06925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LA59_06950	COG3568	Endonuclease Exonuclease Phosphatase
LA59_06960	COG4934	collagen metabolic process
LA59_06995	COG0686	Belongs to the AlaDH PNT family
LA59_07005	COG1674	ftsk spoiiie
LA59_07015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA59_07035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LA59_07040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA59_07075	COG0300	oxidoreductase activity
LA59_07090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA59_07100	COG2268	Band 7 protein
LA59_07110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LA59_07120	COG0482	sulfurtransferase activity
LA59_07130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_07140	COG1757	Na H antiporter
LA59_07150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LA59_07155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LA59_07160	COG0131	Imidazoleglycerol-phosphate dehydratase
LA59_07160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LA59_07165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LA59_07170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LA59_07175	COG0107	imidazoleglycerol-phosphate synthase activity
LA59_07180	COG0140	phosphoribosyl-ATP diphosphatase activity
LA59_07180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LA59_07185	COG3012	SEC-C Motif Domain Protein
LA59_07190	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LA59_07195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA59_07200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA59_07205	COG0215	cysteine-tRNA ligase activity
LA59_07210	COG1435	thymidine kinase activity
LA59_07215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LA59_07240	COG2116	formate transmembrane transporter activity
LA59_07245	COG0390	transport system, permease component
LA59_07250	COG4459	periplasmic nitrate reductase
LA59_07255	COG3005	denitrification pathway
LA59_07260	COG0243	molybdopterin cofactor binding
LA59_07275	COG1121	(ABC) transporter
LA59_07280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_07285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_07290	COG1227	inorganic diphosphatase activity
LA59_07300	COG4172	Belongs to the ABC transporter superfamily
LA59_07310	COG4171	peptide transport system, permease
LA59_07315	COG4168	peptide transport system, permease
LA59_07325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LA59_07330	COG1842	Phage shock protein A
LA59_07360	COG2818	Glycosylase
LA59_07365	COG5380	lipid catabolic process
LA59_07370	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LA59_07375	COG0626	cystathionine gamma-synthase activity
LA59_07385	COG0733	neurotransmitter:sodium symporter activity
LA59_07395	COG0564	pseudouridine synthase activity
LA59_07405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA59_07410	COG1151	hydroxylamine reductase activity
LA59_07415	COG3604	Transcriptional regulator
LA59_07420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LA59_07425	COG4136	ATPase activity
LA59_07430	COG4135	transport system, permease component
LA59_07435	COG4134	Bacterial extracellular solute-binding protein
LA59_07440	COG0398	Pfam SNARE associated Golgi protein
LA59_07450	COG0493	'glutamate synthase
LA59_07475	COG0659	secondary active sulfate transmembrane transporter activity
LA59_07485	COG3313	Fe-S protein
LA59_07525	COG2205	protein histidine kinase activity
LA59_07530	COG0745	RESPONSE REGULATOR receiver
LA59_07540	COG1061	Type III restriction enzyme res subunit
LA59_07545	COG1187	pseudouridine synthase activity
LA59_07550	COG2814	Major facilitator Superfamily
LA59_07560	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_07570	COG1609	Transcriptional regulator
LA59_07575	COG0702	epimerase
LA59_07580	COG0534	Mate efflux family protein
LA59_07585	COG4181	ATPase activity
LA59_07615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LA59_07625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA59_07635	COG1737	Transcriptional regulator
LA59_07640	COG0076	glutamate decarboxylase activity
LA59_07650	COG2431	L-lysine efflux transmembrane transporter activity
LA59_07660	COG3070	regulator of competence-specific genes
LA59_07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_07675	COG4191	Histidine kinase
LA59_07685	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LA59_07695	COG3706	GGDEF domain
LA59_07715	COG0583	DNA-binding transcription factor activity
LA59_07720	COG2610	gluconate transmembrane transporter activity
LA59_07730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LA59_07735	COG4988	ABC transporter
LA59_07740	COG0492	ferredoxin-NADP+ reductase activity
LA59_07760	COG3706	GGDEF domain
LA59_07765	COG0471	metal ion transport
LA59_07770	COG2949	membrane
LA59_07780	COG1643	Atp-dependent helicase
LA59_07820	COG0471	metal ion transport
LA59_07825	COG4191	Histidine kinase
LA59_07825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_07835	COG5001	Diguanylate cyclase
LA59_07835	COG3300	MHYT domain
LA59_07845	COG1280	lysine exporter protein (LysE YggA)
LA59_07850	COG1328	CTP reductase activity
LA59_07855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA59_07865	COG0861	Integral membrane protein TerC family
LA59_07875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA59_07885	COG3706	GGDEF domain
LA59_07895	COG1454	alcohol dehydrogenase
LA59_07900	COG0814	amino acid
LA59_07915	COG1120	ATPase activity
LA59_07920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LA59_07925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA59_07930	COG4774	siderophore transport
LA59_07945	COG1132	(ABC) transporter
LA59_07950	COG1132	(ABC) transporter
LA59_07965	COG0583	DNA-binding transcription factor activity
LA59_07990	COG0443	Heat shock 70 kDa protein
LA59_07995	COG0443	Heat shock 70 kDa protein
LA59_08005	COG3706	GGDEF domain
LA59_08035	COG0243	molybdopterin cofactor binding
LA59_08040	COG0437	4 iron, 4 sulfur cluster binding
LA59_08045	COG3302	dmso reductase anchor subunit
LA59_08060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LA59_08065	COG1643	Atp-dependent helicase
LA59_08090	COG3063	Type IV pilus biogenesis stability protein PilW
LA59_08115	COG0531	amino acid
LA59_08125	COG1280	lysine exporter protein (LysE YggA)
LA59_08130	COG0583	DNA-binding transcription factor activity
LA59_08135	COG1560	Kdo2-lipid A biosynthetic process
LA59_08150	COG1846	Transcriptional regulator
LA59_08165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LA59_08270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LA59_08275	COG2197	response regulator
LA59_08310	COG1280	lysine exporter protein (LysE YggA)
LA59_08325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_08335	COG0730	response to heat
LA59_08360	COG0456	acetyltransferase
LA59_08370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LA59_08465	COG3501	Rhs element vgr protein
LA59_08480	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LA59_08485	COG0372	Belongs to the citrate synthase family
LA59_08495	COG2828	Protein conserved in bacteria
LA59_08520	COG0561	phosphatase activity
LA59_08525	COG0602	queuosine metabolic process
LA59_08535	COG2199	diguanylate cyclase activity
LA59_08535	COG2203	Gaf domain
LA59_08570	COG3064	Membrane
LA59_08580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA59_08590	COG0297	glycogen (starch) synthase activity
LA59_08630	COG2204	response regulator
LA59_08660	COG1793	dna ligase
LA59_08670	COG0534	Mate efflux family protein
LA59_08675	COG0307	riboflavin synthase, alpha
LA59_08690	COG2201	protein-glutamate methylesterase activity
LA59_08695	COG3706	GGDEF domain
LA59_08705	COG0791	NLP P60 protein
LA59_08710	COG0840	transmembrane signaling receptor activity
LA59_08755	COG1940	carbohydrate kinase activity
LA59_08765	COG0303	'Molybdopterin
LA59_08775	COG3842	ATPase activity
LA59_08780	COG4662	Binding-protein-dependent transport system inner membrane component
LA59_08790	COG2204	response regulator
LA59_08795	COG4191	Histidine kinase
LA59_08810	COG0488	(ABC) transporter
LA59_08820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LA59_08840	COG3381	protein complex oligomerization
LA59_08850	COG0243	molybdopterin cofactor binding
LA59_08850	COG3383	formate dehydrogenase (NAD+) activity
LA59_08855	COG0437	4 iron, 4 sulfur cluster binding
LA59_08875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LA59_08880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LA59_08885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LA59_08890	COG1177	transmembrane transport
LA59_08895	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA59_08900	COG3842	ATPase activity
LA59_08910	COG2992	FlgJ-related protein
LA59_08925	COG0589	response to stress
LA59_08930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA59_08945	COG2217	Heavy metal translocating P-type atpase
LA59_08955	COG2010	Cytochrome c
LA59_08970	COG3278	Belongs to the heme-copper respiratory oxidase family
LA59_08985	COG2205	protein histidine kinase activity
LA59_08985	COG0784	Response regulator, receiver
LA59_09015	COG1067	ATP-dependent peptidase activity
LA59_09020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LA59_09060	COG2902	Dehydrogenase
LA59_09065	COG0308	aminopeptidase N
LA59_09080	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LA59_09085	COG1956	GAF domain-containing protein
LA59_09090	COG1132	(ABC) transporter
LA59_09095	COG2995	paraquat-inducible protein a
LA59_09100	COG3008	intermembrane lipid transfer
LA59_09125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA59_09140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_09145	COG4597	amino acid ABC transporter
LA59_09150	COG0765	amino acid transport
LA59_09155	COG1126	abc transporter atp-binding protein
LA59_09160	COG0670	Belongs to the BI1 family
LA59_09165	COG2920	part of a sulfur-relay system
LA59_09170	COG1254	Belongs to the acylphosphatase family
LA59_09200	COG5001	Diguanylate cyclase
LA59_09200	COG3300	MHYT domain
LA59_09205	COG2205	protein histidine kinase activity
LA59_09205	COG3437	response regulator, receiver
LA59_09205	COG3850	Histidine kinase
LA59_09205	COG4999	Histidine kinase
LA59_09220	COG0110	maltose O-acetyltransferase activity
LA59_09240	COG1846	Transcriptional regulator
LA59_09250	COG3247	response to pH
LA59_09255	COG0668	transmembrane transport
LA59_09270	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LA59_09330	COG4964	Belongs to the GSP D family
LA59_09350	COG0393	Putative heavy-metal-binding
LA59_09355	COG3152	Membrane
LA59_09365	COG2207	Transcriptional regulator
LA59_09385	COG0589	response to stress
LA59_09390	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LA59_09395	COG0363	glucosamine-6-phosphate deaminase activity
LA59_09400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA59_09405	COG4977	sequence-specific DNA binding
LA59_09410	COG4774	siderophore transport
LA59_09415	COG4565	transcriptional regulatory protein
LA59_09420	COG3290	protein histidine kinase activity
LA59_09435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_09460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_09465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_09470	COG0387	Pfam Sodium calcium exchanger
LA59_09480	COG2239	Acts as a magnesium transporter
LA59_09500	COG0583	DNA-binding transcription factor activity
LA59_09505	COG0668	transmembrane transport
LA59_09525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LA59_09555	COG2186	Transcriptional regulator
LA59_09570	COG0702	epimerase
LA59_09575	COG0583	DNA-binding transcription factor activity
LA59_09580	COG1404	Belongs to the peptidase S8 family
LA59_09585	COG1858	cytochrome C peroxidase
LA59_09595	COG0527	aspartate kinase activity
LA59_09600	COG0662	Cupin 2, conserved barrel domain protein
LA59_09605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LA59_09610	COG0456	acetyltransferase
LA59_09615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_09625	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LA59_09630	COG0534	Mate efflux family protein
LA59_09645	COG1368	sulfuric ester hydrolase activity
LA59_09680	COG1115	amino acid carrier protein
LA59_09685	COG1012	belongs to the aldehyde dehydrogenase family
LA59_09690	COG3284	Transcriptional regulator
LA59_09720	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LA59_09725	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
LA59_09730	COG3051	citrate lyase alpha subunit
LA59_09735	COG2301	Belongs to the HpcH HpaI aldolase family
LA59_09740	COG3052	prosthetic group binding
LA59_09745	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LA59_09755	COG3630	sodium ion export across plasma membrane
LA59_09760	COG5016	pyruvate
LA59_09760	COG0511	ligase activity, forming carbon-carbon bonds
LA59_09765	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LA59_09775	COG4565	transcriptional regulatory protein
LA59_09815	COG1051	belongs to the nudix hydrolase family
LA59_09865	COG0625	glutathione transferase activity
LA59_09875	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LA59_09890	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA59_09900	COG0601	transmembrane transport
LA59_09905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_09910	COG0444	Belongs to the ABC transporter superfamily
LA59_09935	COG3291	Pkd domain containing protein
LA59_09950	COG0745	RESPONSE REGULATOR receiver
LA59_09960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_09965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_09985	COG0813	purine-nucleoside phosphorylase activity
LA59_09990	COG1177	transmembrane transport
LA59_09995	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA59_10030	COG1451	nucleotide metabolic process
LA59_10055	COG0583	DNA-binding transcription factor activity
LA59_10100	COG4139	cobalamin transport
LA59_10115	COG2062	phosphohistidine phosphatase, SixA
LA59_10125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LA59_10135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LA59_10140	COG0702	epimerase
LA59_10155	COG2925	Exonuclease
LA59_10165	COG1346	cytolysis
LA59_10230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA59_10230	COG0072	phenylalanine-tRNA ligase activity
LA59_10285	COG0251	oxidation-reduction process
LA59_10295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LA59_10320	COG2188	Transcriptional regulator
LA59_10330	COG0010	Belongs to the arginase family
LA59_10340	COG2986	histidine ammonia-lyase
LA59_10355	COG0277	FAD linked oxidase domain protein
LA59_10355	COG0247	lactate metabolic process
LA59_10425	COG0519	Catalyzes the synthesis of GMP from XMP
LA59_10660	COG0662	Cupin 2, conserved barrel domain protein
LA59_10935	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LA59_11020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA59_11035	COG3106	COG3106 Predicted ATPase
LA59_11050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA59_11055	COG2205	protein histidine kinase activity
LA59_11055	COG0784	Response regulator, receiver
LA59_11070	COG0814	amino acid
LA59_11075	COG1760	l-serine dehydratase
LA59_11080	COG5001	Diguanylate cyclase
LA59_11080	COG3300	MHYT domain
LA59_11090	COG2197	response regulator
LA59_11095	COG0720	synthase
LA59_11100	COG0840	transmembrane signaling receptor activity
LA59_11105	COG0017	Asparaginyl-tRNA synthetase
LA59_11120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA59_11135	COG3437	response regulator, receiver
LA59_11135	COG2770	Histidine kinase
LA59_11140	COG1448	Aminotransferase
LA59_11160	COG0840	transmembrane signaling receptor activity
LA59_11165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_11170	COG1846	Transcriptional regulator
LA59_11195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LA59_11210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA59_11215	COG3108	Peptidase M15
LA59_11220	COG2989	Protein conserved in bacteria
LA59_11245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LA59_11255	COG4235	cytochrome complex assembly
LA59_11255	COG3088	subunit of a heme lyase
LA59_11265	COG1138	Cytochrome C-type biogenesis protein
LA59_11270	COG3301	Polysulphide reductase, NrfD
LA59_11275	COG0437	4 iron, 4 sulfur cluster binding
LA59_11285	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LA59_11305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA59_11315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA59_11320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA59_11345	COG0019	diaminopimelate decarboxylase activity
LA59_11390	COG0322	excinuclease ABC activity
LA59_11395	COG2197	response regulator
LA59_11400	COG0417	DNA replication proofreading
LA59_11420	COG1187	pseudouridine synthase activity
LA59_11430	COG0009	L-threonylcarbamoyladenylate synthase
LA59_11435	COG0613	PHP domain protein
LA59_11445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA59_11450	COG0512	Glutamine amidotransferase of anthranilate synthase
LA59_11460	COG0134	indole-3-glycerol-phosphate synthase activity
LA59_11460	COG0135	phosphoribosylanthranilate isomerase activity
LA59_11470	COG0159	tryptophan synthase activity
LA59_11475	COG1301	dicarboxylic acid transport
LA59_11500	COG1607	acyl-coa hydrolase
LA59_11505	COG2350	Protein conserved in bacteria
LA59_11535	COG5001	Diguanylate cyclase
LA59_11535	COG1716	ATPase activity
LA59_11540	COG1032	radical SAM domain protein
LA59_11565	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA59_11580	COG2964	Protein conserved in bacteria
LA59_11585	COG0840	transmembrane signaling receptor activity
LA59_11595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LA59_11600	COG0463	Glycosyl transferase, family 2
LA59_11605	COG0745	RESPONSE REGULATOR receiver
LA59_11610	COG5002	protein histidine kinase activity
LA59_11610	COG3850	Histidine kinase
LA59_11645	COG1846	Transcriptional regulator
LA59_11660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LA59_11690	COG0577	efflux transmembrane transporter activity
LA59_11690	COG1136	(ABC) transporter
LA59_11700	COG0577	efflux transmembrane transporter activity
LA59_11725	COG3153	acetyltransferase
LA59_11755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA59_11765	COG3118	belongs to the thioredoxin family
LA59_11770	COG4232	protein-disulfide reductase activity
LA59_11785	COG2995	paraquat-inducible protein a
LA59_11790	COG3008	intermembrane lipid transfer
LA59_11790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA59_11795	COG3009	Protein conserved in bacteria
LA59_11850	COG4166	transmembrane transport
LA59_11860	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LA59_11865	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LA59_11875	COG0539	negative regulation of cytoplasmic translation
LA59_11885	COG0616	signal peptide processing
LA59_11890	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_11910	COG0784	Response regulator, receiver
LA59_11910	COG0835	chemotaxis
LA59_11915	COG1940	carbohydrate kinase activity
LA59_11925	COG4667	esterase of the alpha-beta hydrolase superfamily
LA59_11940	COG0733	neurotransmitter:sodium symporter activity
LA59_11950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_11950	COG1263	PTS System
LA59_11955	COG0084	hydrolase, TatD family'
LA59_11970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA59_12000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LA59_12015	COG1399	metal-binding, possibly nucleic acid-binding protein
LA59_12020	COG0424	maF-like protein
LA59_12025	COG0564	pseudouridine synthase activity
LA59_12040	COG0659	secondary active sulfate transmembrane transporter activity
LA59_12045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LA59_12050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LA59_12080	COG2186	Transcriptional regulator
LA59_12090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LA59_12095	COG0653	protein targeting
LA59_12100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA59_12105	COG3706	GGDEF domain
LA59_12110	COG0366	Alpha amylase catalytic
LA59_12115	COG1122	ATPase activity
LA59_12120	COG4120	Belongs to the binding-protein-dependent transport system permease family
LA59_12145	COG0857	belongs to the CobB CobQ family
LA59_12145	COG0280	phosphate acetyltransferase
LA59_12150	COG3174	membrane
LA59_12155	COG0435	Glutathione S-transferase
LA59_12165	COG0444	Belongs to the ABC transporter superfamily
LA59_12170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_12175	COG0601	transmembrane transport
LA59_12185	COG0314	molybdopterin synthase activity
LA59_12190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LA59_12200	COG0521	Mo-molybdopterin cofactor biosynthetic process
LA59_12205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LA59_12210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LA59_12225	COG0556	nucleotide-excision repair
LA59_12235	COG1882	Formate acetyltransferase
LA59_12240	COG4657	Part of a membrane complex involved in electron transport
LA59_12250	COG4656	Part of a membrane complex involved in electron transport
LA59_12255	COG4658	electron transport chain
LA59_12260	COG4659	FMN binding
LA59_12265	COG4660	Part of a membrane complex involved in electron transport
LA59_12270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA59_12275	COG0346	lactoylglutathione lyase activity
LA59_12285	COG2885	chlorophyll binding
LA59_12295	COG2056	Na+-H+ antiporter family
LA59_12355	COG3504	Conjugal transfer protein
LA59_12385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA59_12395	COG3457	Alanine racemase
LA59_12420	COG1278	Cold shock
LA59_12440	COG3457	Alanine racemase
LA59_12465	COG0330	HflC and HflK could
LA59_12475	COG0861	Integral membrane protein TerC family
LA59_12480	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_12490	COG0633	Ferredoxin
LA59_12490	COG3217	Mosc domain protein beta barrel domain protein
LA59_12500	COG0583	DNA-binding transcription factor activity
LA59_12510	COG2814	Major facilitator Superfamily
LA59_12515	COG0583	DNA-binding transcription factor activity
LA59_12605	COG2003	Belongs to the UPF0758 family
LA59_12660	COG4974	Belongs to the 'phage' integrase family
LA59_12665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA59_12685	COG1012	belongs to the aldehyde dehydrogenase family
LA59_12685	COG1454	alcohol dehydrogenase
LA59_12690	COG2095	MarC family integral membrane protein
LA59_12695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA59_12705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA59_12710	COG1757	Na H antiporter
LA59_12735	COG3083	sulfuric ester hydrolase activity
LA59_12745	COG0123	including yeast histone deacetylase and acetoin utilization protein
LA59_12760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LA59_12765	COG0778	Nitroreductase
LA59_12770	COG1902	pentaerythritol trinitrate reductase activity
LA59_12770	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA59_12775	COG0616	signal peptide processing
LA59_12780	COG0252	asparaginase activity
LA59_12785	COG3139	Protein of unknown function (DUF1315)
LA59_12795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA59_12800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA59_12820	COG2226	methyltransferase
LA59_12840	COG1785	Belongs to the alkaline phosphatase family
LA59_12850	COG0346	lactoylglutathione lyase activity
LA59_12855	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LA59_12860	COG0668	transmembrane transport
LA59_12865	COG2261	transglycosylase associated protein
LA59_12870	COG2983	Belongs to the UPF0260 family
LA59_12880	COG2964	Protein conserved in bacteria
LA59_12890	COG0251	oxidation-reduction process
LA59_12895	COG0814	amino acid
LA59_12900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LA59_12905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LA59_12915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LA59_12925	COG2832	Protein of unknown function (DUF454)
LA59_12935	COG0745	RESPONSE REGULATOR receiver
LA59_12940	COG0583	DNA-binding transcription factor activity
LA59_12945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LA59_12950	COG1286	toxin biosynthetic process
LA59_12955	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LA59_12960	COG0285	dihydrofolate synthase activity
LA59_12980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LA59_12985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA59_12990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LA59_13010	COG3101	peptidyl-lysine hydroxylation
LA59_13015	COG2860	membrane
LA59_13025	COG2890	protein-(glutamine-N5) methyltransferase activity
LA59_13035	COG2062	phosphohistidine phosphatase, SixA
LA59_13050	COG0183	Belongs to the thiolase family
LA59_13075	COG2853	Lipoprotein
LA59_13080	COG4235	cytochrome complex assembly
LA59_13080	COG3088	subunit of a heme lyase
LA59_13090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA59_13095	COG1138	Cytochrome C-type biogenesis protein
LA59_13110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA59_13115	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA59_13120	COG4133	protoheme IX ABC transporter activity
LA59_13130	COG0835	chemotaxis
LA59_13140	COG1192	Involved in chromosome partitioning
LA59_13145	COG2201	protein-glutamate methylesterase activity
LA59_13150	COG0643	Histidine kinase
LA59_13150	COG2198	Histidine kinase
LA59_13155	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LA59_13170	COG0455	bacterial-type flagellum organization
LA59_13190	COG1684	flagellar biosynthetic protein fliR
LA59_13195	COG1987	bacterial-type flagellum assembly
LA59_13250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LA59_13260	COG1677	Flagellar hook-basal body complex protein FliE
LA59_13265	COG2204	response regulator
LA59_13270	COG4191	Histidine kinase
LA59_13280	COG1516	flagellar protein fliS
LA59_13290	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LA59_13295	COG1334	flagellar protein FlaG
LA59_13300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_13305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_13315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_13320	COG2211	Major facilitator Superfamily
LA59_13325	COG1486	melibiose metabolic process
LA59_13330	COG2169	Transcriptional regulator
LA59_13335	COG2837	iron assimilation
LA59_13360	COG1393	Belongs to the ArsC family
LA59_13385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LA59_13390	COG2716	regulation of RNA biosynthetic process
LA59_13395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LA59_13410	COG4783	chaperone-mediated protein folding
LA59_13415	COG1393	Belongs to the ArsC family
LA59_13435	COG2233	PERMEase
LA59_13440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LA59_13445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LA59_13450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LA59_13455	COG0121	glutamine amidotransferase
LA59_13460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LA59_13485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LA59_13495	COG2226	methyltransferase
LA59_13505	COG0741	lytic transglycosylase activity
LA59_13505	COG1388	LysM domain
LA59_13520	COG0347	Belongs to the P(II) protein family
LA59_13540	COG0587	DNA-directed DNA polymerase activity
LA59_13565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LA59_13570	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LA59_13580	COG0750	zinc metalloprotease
LA59_13590	COG0575	Belongs to the CDS family
LA59_13595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LA59_13620	COG0024	Methionine aminopeptidase
LA59_13635	COG0564	pseudouridine synthase activity
LA59_13640	COG3098	single-species biofilm formation
LA59_13680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA59_13705	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LA59_13715	COG1720	tRNA m6t6A37 methyltransferase activity
LA59_13740	COG0733	neurotransmitter:sodium symporter activity
LA59_13755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA59_13760	COG0514	ATP-dependent DNA helicase (RecQ)
LA59_13765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LA59_13770	COG3706	GGDEF domain
LA59_13770	COG0745	RESPONSE REGULATOR receiver
LA59_13780	COG1477	protein flavinylation
LA59_13790	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LA59_13815	COG0271	Belongs to the BolA IbaG family
LA59_13845	COG1595	DNA-templated transcription, initiation
LA59_13860	COG3248	Nucleoside-binding outer membrane protein
LA59_13865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LA59_13870	COG0693	protein deglycase activity
LA59_13875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LA59_13880	COG2166	iron-sulfur cluster assembly
LA59_13885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LA59_13890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LA59_13900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LA59_13900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LA59_13910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LA59_13915	COG1074	ATP-dependent DNA helicase activity
LA59_13920	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LA59_13940	COG3141	response to X-ray
LA59_13955	COG2171	N-acyltransferase activity
LA59_13960	COG0584	glycerophosphoryl diester phosphodiesterase
LA59_13965	COG2271	Major facilitator Superfamily
LA59_13970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LA59_13980	COG1349	DNA-binding transcription factor activity
LA59_13985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LA59_14005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LA59_14015	COG2017	converts alpha-aldose to the beta-anomer
LA59_14030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA59_14035	COG0768	penicillin binding
LA59_14045	COG1609	Transcriptional regulator
LA59_14050	COG3250	beta-galactosidase activity
LA59_14055	COG2731	YhcH YjgK YiaL family protein
LA59_14060	COG0531	amino acid
LA59_14065	COG0583	DNA-binding transcription factor activity
LA59_14125	COG4964	Belongs to the GSP D family
LA59_14150	COG2169	Transcriptional regulator
LA59_14155	COG1022	Amp-dependent synthetase and ligase
LA59_14165	COG0583	DNA-binding transcription factor activity
LA59_14170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LA59_14175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LA59_14185	COG0560	Phosphoserine phosphatase
LA59_14195	COG0813	purine-nucleoside phosphorylase activity
LA59_14205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LA59_14215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA59_14220	COG0084	hydrolase, TatD family'
LA59_14225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LA59_14230	COG3706	GGDEF domain
LA59_14250	COG3153	acetyltransferase
LA59_14275	COG0534	Mate efflux family protein
LA59_14295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LA59_14315	COG0195	Participates in both transcription termination and antitermination
LA59_14335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA59_14345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LA59_14350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LA59_14360	COG1534	Rna-binding protein
LA59_14365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LA59_14370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LA59_14375	COG2027	D-alanyl-D-alanine carboxypeptidase
LA59_14385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LA59_14390	COG0739	heme binding
LA59_14405	COG0316	Belongs to the HesB IscA family
LA59_14415	COG0628	permease
LA59_14430	COG2205	protein histidine kinase activity
LA59_14430	COG2198	Histidine kinase
LA59_14430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_14430	COG0784	Response regulator, receiver
LA59_14435	COG0747	negative chemotaxis
LA59_14445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_14450	COG0444	Belongs to the ABC transporter superfamily
LA59_14455	COG4608	Belongs to the ABC transporter superfamily
LA59_14465	COG2971	BadF BadG BcrA BcrD
LA59_14480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA59_14485	COG3842	ATPase activity
LA59_14495	COG1840	ABC-type Fe3 transport system, periplasmic component
LA59_14500	COG0004	ammonium transporteR
LA59_14515	COG1049	propionate catabolic process, 2-methylcitrate cycle
LA59_14520	COG1752	Esterase of the alpha-beta hydrolase superfamily
LA59_14525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA59_14530	COG1643	Atp-dependent helicase
LA59_14540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LA59_14545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LA59_14555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA59_14570	COG1560	Kdo2-lipid A biosynthetic process
LA59_14575	COG0842	Transport permease protein
LA59_14580	COG1131	(ABC) transporter
LA59_14585	COG0659	secondary active sulfate transmembrane transporter activity
LA59_14590	COG0288	reversible hydration of carbon dioxide
LA59_14605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_14610	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA59_14615	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LA59_14620	COG2186	Transcriptional regulator
LA59_14645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA59_14650	COG1459	type II secretion system
LA59_14660	COG0237	dephospho-CoA kinase activity
LA59_14665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LA59_14670	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LA59_14695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA59_14700	COG4137	Cytochrome C assembly protein
LA59_14705	COG4536	flavin adenine dinucleotide binding
LA59_14725	COG0612	Peptidase, M16
LA59_14730	COG1238	metal cluster binding
LA59_14740	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LA59_14745	COG5016	pyruvate
LA59_14745	COG0511	ligase activity, forming carbon-carbon bonds
LA59_14810	COG0527	aspartate kinase activity
LA59_14825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LA59_14830	COG1546	Belongs to the CinA family
LA59_14840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LA59_14870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LA59_14880	COG0148	phosphopyruvate hydratase activity
LA59_14890	COG3956	TIGRFAM MazG family protein
LA59_14895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA59_14915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LA59_14920	COG1381	Involved in DNA repair and RecF pathway recombination
LA59_14925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LA59_14935	COG0681	Belongs to the peptidase S26 family
LA59_14945	COG3086	response to oxidative stress
LA59_14960	COG1595	DNA-templated transcription, initiation
LA59_14965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LA59_14975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LA59_14995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA59_15000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LA59_15010	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LA59_15015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LA59_15025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LA59_15035	COG0583	DNA-binding transcription factor activity
LA59_15050	COG0668	transmembrane transport
LA59_15055	COG0191	fructose-bisphosphate aldolase activity
LA59_15075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA59_15095	COG2356	endonuclease I
LA59_15100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA59_15105	COG0189	ligase activity
LA59_15110	COG1678	Uncharacterized ACR, COG1678
LA59_15115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LA59_15130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LA59_15135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LA59_15140	COG0762	integral membrane protein
LA59_15155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LA59_15160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA59_15260	COG1012	belongs to the aldehyde dehydrogenase family
LA59_15305	COG3437	response regulator, receiver
LA59_15320	COG1486	melibiose metabolic process
LA59_15325	COG1447	Phosphotransferase system cellobiose-specific component IIA
LA59_15335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LA59_15355	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_15365	COG0795	lipopolysaccharide-transporting ATPase activity
LA59_15370	COG0795	lipopolysaccharide-transporting ATPase activity
LA59_15380	COG2927	DNA polymerase III (CHI subunit)
LA59_15385	COG0525	valine-tRNA ligase activity
LA59_15395	COG0456	acetyltransferase
LA59_15430	COG0251	oxidation-reduction process
LA59_15435	COG0204	Acyl-transferase
LA59_15445	COG5007	Belongs to the BolA IbaG family
LA59_15455	COG2854	intermembrane phospholipid transfer
LA59_15460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA59_15465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA59_15470	COG1127	ABC transporter
LA59_15480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LA59_15480	COG0517	IMP dehydrogenase activity
LA59_15490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LA59_15495	COG1137	ATPase activity
LA59_15505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LA59_15510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_15520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_15525	COG2239	Acts as a magnesium transporter
LA59_15530	COG0312	modulator of DNA gyrase
LA59_15540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA59_15545	COG0564	pseudouridine synthase activity
LA59_15560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LA59_15565	COG0312	modulator of DNA gyrase
LA59_15570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA59_15575	COG3164	Protein of unknown function
LA59_15580	COG1530	ribonuclease E activity
LA59_15585	COG0424	maF-like protein
LA59_15590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LA59_15595	COG1792	Involved in formation and maintenance of cell shape
LA59_15600	COG1077	Cell shape determining protein MreB Mrl
LA59_15645	COG1459	type II secretion system
LA59_15650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LA59_15660	COG3409	Peptidoglycan-binding domain 1 protein
LA59_15660	COG3267	Type II secretory pathway component ExeA
LA59_15685	COG2200	EAL domain
LA59_15685	COG2199	diguanylate cyclase activity
LA59_15690	COG0629	single-stranded DNA binding
LA59_15705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LA59_15715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LA59_15720	COG0527	aspartate kinase activity
LA59_15725	COG0646	methionine synthase
LA59_15725	COG1410	methionine synthase
LA59_15795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LA59_15815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA59_15935	COG0735	belongs to the Fur family
LA59_15950	COG0432	Pfam Uncharacterised protein family UPF0047
LA59_15960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LA59_15965	COG0305	Participates in initiation and elongation during chromosome replication
LA59_15990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LA59_15995	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LA59_16040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LA59_16050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA59_16050	COG0678	peroxiredoxin activity
LA59_16055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA59_16065	COG0165	Argininosuccinate lyase
LA59_16065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LA59_16080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LA59_16090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LA59_16100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LA59_16105	COG0527	aspartate kinase activity
LA59_16105	COG0460	homoserine dehydrogenase
LA59_16110	COG0626	cystathionine gamma-synthase activity
LA59_16120	COG0281	malic enzyme
LA59_16130	COG2906	2 iron, 2 sulfur cluster binding
LA59_16140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LA59_16155	COG2168	tRNA wobble position uridine thiolation
LA59_16160	COG2923	Belongs to the DsrF TusC family
LA59_16165	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LA59_16170	COG2964	Protein conserved in bacteria
LA59_16175	COG0545	Peptidyl-prolyl cis-trans isomerase
LA59_16190	COG1446	asparaginase
LA59_16195	COG1047	Peptidyl-prolyl cis-trans
LA59_16210	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA59_16215	COG0488	(ABC) transporter
LA59_16225	COG0429	hydrolase of the alpha beta-hydrolase fold
LA59_16235	COG3954	Phosphoribulokinase
LA59_16240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA59_16260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LA59_16265	COG0512	Glutamine amidotransferase of anthranilate synthase
LA59_16290	COG0546	phosphoglycolate phosphatase activity
LA59_16295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA59_16300	COG0557	exoribonuclease II activity
LA59_16310	COG1017	nitric oxide dioxygenase activity
LA59_16310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA59_16315	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LA59_16320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LA59_16325	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LA59_16330	COG0330	HflC and HflK could
LA59_16335	COG0330	HflC and HflK could
LA59_16340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA59_16355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LA59_16365	COG0802	atpase or kinase
LA59_16370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LA59_16440	COG1162	GTPase activity
LA59_16450	COG0471	metal ion transport
LA59_16455	COG0840	transmembrane signaling receptor activity
LA59_16465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LA59_16470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA59_16475	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LA59_16485	COG1045	serine acetyltransferase
LA59_16490	COG4942	peptidase
LA59_16515	COG1053	succinate dehydrogenase
LA59_16520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LA59_16550	COG1509	lysine 2,3-aminomutase activity
LA59_16575	COG0534	Mate efflux family protein
LA59_16585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LA59_16590	COG3678	ATP-independent chaperone mediated protein folding
LA59_16595	COG0745	RESPONSE REGULATOR receiver
LA59_16600	COG2205	protein histidine kinase activity
LA59_16605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA59_16610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LA59_16615	COG3030	protein affecting phage T7 exclusion by the F plasmid
LA59_16620	COG1027	Aspartate ammonia-lyase
LA59_16625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LA59_16630	COG4232	protein-disulfide reductase activity
LA59_16640	COG2095	MarC family integral membrane protein
LA59_16650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_16670	COG2198	Histidine kinase
LA59_16670	COG0784	Response regulator, receiver
LA59_16670	COG2205	protein histidine kinase activity
LA59_16675	COG2814	Major facilitator Superfamily
LA59_16690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LA59_16695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LA59_16700	COG0511	ligase activity, forming carbon-carbon bonds
LA59_16705	COG0439	Biotin carboxylase
LA59_16715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA59_16720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LA59_16725	COG3300	MHYT domain
LA59_16725	COG5001	Diguanylate cyclase
LA59_16760	COG0277	FAD linked oxidase domain protein
LA59_16765	COG0583	DNA-binding transcription factor activity
LA59_16775	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LA59_16790	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LA59_16800	COG1288	antiporter activity
LA59_16810	COG2814	Major facilitator Superfamily
LA59_16820	COG3040	lipid binding
LA59_16850	COG3469	chitinase activity
LA59_16860	COG0419	ATPase involved in DNA repair
LA59_16865	COG0420	3'-5' exonuclease activity
LA59_16890	COG3209	COG3209 Rhs family protein
LA59_16905	COG3501	Rhs element vgr protein
LA59_16960	COG0631	protein serine/threonine phosphatase activity
LA59_16995	COG0515	serine threonine protein kinase
LA59_16995	COG2815	serine threonine protein kinase
LA59_17020	COG0346	lactoylglutathione lyase activity
LA59_17025	COG1902	pentaerythritol trinitrate reductase activity
LA59_17035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LA59_17035	COG2755	lipolytic protein G-D-S-L family
LA59_17050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LA59_17050	COG0069	glutamate synthase activity
LA59_17060	COG1234	tRNA 3'-trailer cleavage
LA59_17065	COG2067	long-chain fatty acid transport protein
LA59_17135	COG3706	GGDEF domain
LA59_17135	COG0745	RESPONSE REGULATOR receiver
LA59_17140	COG1024	Enoyl-CoA hydratase
LA59_17145	COG0628	permease
LA59_17170	COG3038	cytochrome b561
LA59_17180	COG0739	heme binding
LA59_17230	COG2146	nitrite reductase [NAD(P)H] activity
LA59_17230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA59_17235	COG1116	anion transmembrane transporter activity
LA59_17240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LA59_17245	COG1116	anion transmembrane transporter activity
LA59_17245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LA59_17250	COG3707	response regulator
LA59_17270	COG0243	molybdopterin cofactor binding
LA59_17275	COG0456	acetyltransferase
LA59_17280	COG5001	Diguanylate cyclase
LA59_17280	COG5002	protein histidine kinase activity
LA59_17285	COG0814	amino acid
LA59_17290	COG3706	GGDEF domain
LA59_17310	COG1785	Belongs to the alkaline phosphatase family
LA59_17325	COG0745	RESPONSE REGULATOR receiver
LA59_17355	COG2847	Copper chaperone PCu(A)C
LA59_17360	COG0443	Heat shock 70 kDa protein
LA59_17425	COG3976	FMN-binding domain protein
LA59_17425	COG0431	NADPH-dependent FMN reductase
LA59_17425	COG1053	succinate dehydrogenase
LA59_17430	COG5002	protein histidine kinase activity
LA59_17435	COG0745	RESPONSE REGULATOR receiver
LA59_17465	COG4160	amino acid transport
LA59_17470	COG4215	(ABC) transporter
LA59_17475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_17480	COG1126	abc transporter atp-binding protein
LA59_17515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_17525	COG1012	belongs to the aldehyde dehydrogenase family
LA59_17535	COG0583	DNA-binding transcription factor activity
LA59_17540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LA59_17545	COG0513	Belongs to the DEAD box helicase family
LA59_17550	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LA59_17565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LA59_17590	COG0653	protein targeting
LA59_17625	COG0641	radical SAM
LA59_17645	COG1119	ATPase activity
LA59_17650	COG2200	EAL domain
LA59_17650	COG2771	luxR family
LA59_17670	COG0513	Belongs to the DEAD box helicase family
LA59_17675	COG5002	protein histidine kinase activity
LA59_17675	COG3447	MASE1 domain protein
LA59_17675	COG5001	Diguanylate cyclase
LA59_17680	COG0523	cobalamin synthesis protein
LA59_17705	COG4206	TonB-dependent receptor
LA59_17715	COG0789	Transcriptional regulator
LA59_17720	COG4604	ABC transporter, ATP-binding protein
LA59_17725	COG4605	iron ion homeostasis
LA59_17730	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA59_17735	COG4607	ABC-type enterochelin transport system periplasmic component
LA59_17745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LA59_17760	COG1609	Transcriptional regulator
LA59_17765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_17770	COG1879	ABC-type sugar transport system periplasmic component
LA59_17775	COG1172	Belongs to the binding-protein-dependent transport system permease family
LA59_17780	COG1129	ABC transporter
LA59_17790	COG5001	Diguanylate cyclase
LA59_17795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LA59_17800	COG1794	racemase activity, acting on amino acids and derivatives
LA59_17825	COG0586	Pfam SNARE associated Golgi protein
LA59_17865	COG0784	Response regulator, receiver
LA59_17865	COG2205	protein histidine kinase activity
LA59_17875	COG0784	Response regulator, receiver
LA59_17875	COG2205	protein histidine kinase activity
LA59_17900	COG0330	HflC and HflK could
LA59_17915	COG4175	Glycine betaine
LA59_17915	COG0517	IMP dehydrogenase activity
LA59_17920	COG4176	ABC-type proline glycine betaine transport system permease component
LA59_17950	COG5001	Diguanylate cyclase
LA59_17950	COG5002	protein histidine kinase activity
LA59_17950	COG3447	MASE1 domain protein
LA59_17970	COG0204	Acyl-transferase
LA59_18000	COG2885	chlorophyll binding
LA59_18040	COG0455	bacterial-type flagellum organization
LA59_18050	COG4964	Belongs to the GSP D family
LA59_18070	COG0583	DNA-binding transcription factor activity
LA59_18075	COG1073	alpha beta
LA59_18090	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LA59_18095	COG0714	Associated with various cellular activities
LA59_18105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LA59_18105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LA59_18120	COG4989	oxidoreductase activity
LA59_18145	COG1914	H( )-stimulated, divalent metal cation uptake system
LA59_18160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA59_18210	COG2897	thiosulfate sulfurtransferase activity
LA59_18235	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA59_18240	COG0840	transmembrane signaling receptor activity
LA59_18245	COG2814	Major facilitator Superfamily
LA59_18250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA59_18265	COG1612	heme a metabolic process
LA59_18285	COG1845	cytochrome c oxidase, subunit III
LA59_18290	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LA59_18300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LA59_18305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LA59_18315	COG1280	lysine exporter protein (LysE YggA)
LA59_18335	COG0179	Fumarylacetoacetate (FAA) hydrolase
LA59_18350	COG0697	spore germination
LA59_18365	COG2814	Major facilitator Superfamily
LA59_18370	COG0583	DNA-binding transcription factor activity
LA59_18375	COG5001	Diguanylate cyclase
LA59_18380	COG0739	heme binding
LA59_18410	COG0814	amino acid
LA59_18430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LA59_18435	COG1072	(Pantothenic acid kinase))
LA59_18445	COG1063	alcohol dehydrogenase
LA59_18450	COG2213	PTS system mannitol-specific
LA59_18455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_18460	COG2188	Transcriptional regulator
LA59_18465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_18465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_18465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_18470	COG0383	alpha-mannosidase activity
LA59_18475	COG1482	cell wall glycoprotein biosynthetic process
LA59_18480	COG0747	negative chemotaxis
LA59_18490	COG1733	regulation of RNA biosynthetic process
LA59_18505	COG0798	PFAM Bile acid sodium symporter
LA59_18520	COG1881	PFAM PEBP family protein
LA59_18530	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA59_18545	COG0583	DNA-binding transcription factor activity
LA59_18600	COG0366	Alpha amylase catalytic
LA59_18615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA59_18620	COG0835	chemotaxis
LA59_18620	COG0784	Response regulator, receiver
LA59_18630	COG0748	coenzyme F420 binding
LA59_18635	COG3721	Heme iron utilization protein
LA59_18645	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LA59_18650	COG0811	peptide transport
LA59_18655	COG0848	biopolymer transport protein
LA59_18665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA59_18670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LA59_18685	COG1131	(ABC) transporter
LA59_18690	COG0842	Transport permease protein
LA59_18695	COG0251	oxidation-reduction process
LA59_18710	COG0800	Aldolase
LA59_18715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_18720	COG4145	pantothenate transmembrane transporter activity
LA59_18730	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LA59_18755	COG3383	formate dehydrogenase (NAD+) activity
LA59_18775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_18795	COG0456	acetyltransferase
LA59_18815	COG0612	Peptidase, M16
LA59_18820	COG4178	(ABC) transporter
LA59_18825	COG4771	TonB-dependent receptor
LA59_18835	COG0811	peptide transport
LA59_18840	COG0811	peptide transport
LA59_18845	COG0848	biopolymer transport protein
LA59_18860	COG0494	nUDIX hydrolase
LA59_18870	COG1858	cytochrome C peroxidase
LA59_18875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA59_18885	COG1505	serine-type exopeptidase activity
LA59_18890	COG0488	(ABC) transporter
LA59_18895	COG1720	tRNA m6t6A37 methyltransferase activity
LA59_18915	COG2814	Major facilitator Superfamily
LA59_18930	COG0583	DNA-binding transcription factor activity
LA59_18935	COG0589	response to stress
LA59_18960	COG1175	transmembrane transport
LA59_18965	COG0395	ABC-type sugar transport system, permease component
LA59_18970	COG3842	ATPase activity
LA59_18990	COG1846	Transcriptional regulator
LA59_19005	COG0523	cobalamin synthesis protein
LA59_19015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LA59_19025	COG4667	esterase of the alpha-beta hydrolase superfamily
LA59_19030	COG1741	Belongs to the pirin family
LA59_19035	COG1278	Cold shock
LA59_19050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LA59_19080	COG2226	methyltransferase
LA59_19090	COG3706	GGDEF domain
LA59_19095	COG1686	Belongs to the peptidase S11 family
LA59_19100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_19105	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA59_19110	COG0583	DNA-binding transcription factor activity
LA59_19115	COG0625	glutathione transferase activity
LA59_19125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LA59_19180	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_19205	COG3746	phosphate-selective porin O and P
LA59_19220	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_19230	COG1301	dicarboxylic acid transport
LA59_19235	COG1252	NADH dehydrogenase
LA59_19245	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LA59_19250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LA59_19285	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_19290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA59_19300	COG0573	inorganic phosphate transmembrane transporter activity
LA59_19310	COG4191	Histidine kinase
LA59_19320	COG0110	maltose O-acetyltransferase activity
LA59_19345	COG2197	response regulator
LA59_19355	COG0840	transmembrane signaling receptor activity
LA59_19360	COG0714	Associated with various cellular activities
LA59_19380	COG2304	oxidoreductase activity
LA59_19395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LA59_19400	COG0581	inorganic phosphate transmembrane transporter activity
LA59_19405	COG0573	inorganic phosphate transmembrane transporter activity
LA59_19410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LA59_19415	COG0840	transmembrane signaling receptor activity
LA59_19425	COG0513	Belongs to the DEAD box helicase family
LA59_19435	COG1376	ErfK ybiS ycfS ynhG family protein
LA59_19435	COG1388	LysM domain
LA59_19440	COG0415	Belongs to the DNA photolyase family
LA59_19450	COG3272	Protein of unknown function (DUF1722)
LA59_19455	COG0813	purine-nucleoside phosphorylase activity
LA59_19470	COG3706	GGDEF domain
LA59_19485	COG1566	PFAM secretion protein HlyD family protein
LA59_19495	COG1122	ATPase activity
LA59_19515	COG0348	domain, Protein
LA59_19520	COG0437	4 iron, 4 sulfur cluster binding
LA59_19525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA59_19555	COG1067	ATP-dependent peptidase activity
LA59_19565	COG4172	Belongs to the ABC transporter superfamily
LA59_19570	COG1505	serine-type exopeptidase activity
LA59_19575	COG0583	DNA-binding transcription factor activity
LA59_19580	COG1620	l-lactate permease
LA59_19585	COG1304	FMN binding
LA59_19595	COG0668	transmembrane transport
LA59_19610	COG4948	Mandelate Racemase Muconate Lactonizing
LA59_19615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LA59_19635	COG1342	Belongs to the UPF0251 family
LA59_19645	COG4176	ABC-type proline glycine betaine transport system permease component
LA59_19650	COG4175	Glycine betaine
LA59_19650	COG3448	diguanylate cyclase activity
LA59_19665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LA59_19670	COG0589	response to stress
LA59_19675	COG0583	DNA-binding transcription factor activity
LA59_19725	COG1335	isochorismatase
LA59_19740	COG0753	catalase activity
LA59_19765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LA59_19770	COG1263	PTS System
LA59_19770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_19775	COG1609	Transcriptional regulator
LA59_19780	COG1349	DNA-binding transcription factor activity
LA59_19785	COG0346	lactoylglutathione lyase activity
LA59_19800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_19800	COG1263	PTS System
LA59_19805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LA59_19810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LA59_19815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA59_19820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LA59_19825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA59_19840	COG0561	phosphatase activity
LA59_19855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_19860	COG3537	Alpha-1,2-mannosidase
LA59_19865	COG3537	Alpha-1,2-mannosidase
LA59_19875	COG3537	Alpha-1,2-mannosidase
LA59_19880	COG3537	Alpha-1,2-mannosidase
LA59_19895	COG1280	lysine exporter protein (LysE YggA)
LA59_19900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA59_19915	COG3226	Transcriptional regulator
LA59_19940	COG0435	Glutathione S-transferase
LA59_19945	COG0431	NADPH-dependent FMN reductase
LA59_19950	COG0583	DNA-binding transcription factor activity
LA59_19955	COG4628	conserved protein (DUF2132)
LA59_19960	COG0488	(ABC) transporter
LA59_19975	COG0346	lactoylglutathione lyase activity
LA59_19980	COG0384	phenazine biosynthesis protein PhzF
LA59_19995	COG3220	belongs to the UPF0276 family
LA59_20010	COG1271	oxidase subunit
LA59_20015	COG1294	oxidase, subunit
LA59_20045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LA59_20050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LA59_20065	COG2205	protein histidine kinase activity
LA59_20070	COG0745	RESPONSE REGULATOR receiver
LA59_20080	COG0454	-acetyltransferase
LA59_20090	COG2814	Major facilitator Superfamily
LA59_20105	COG0583	DNA-binding transcription factor activity
LA59_20110	COG2988	succinylglutamate desuccinylase activity
LA59_20150	COG0628	permease
LA59_20155	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LA59_20180	COG4628	conserved protein (DUF2132)
LA59_20185	COG0583	DNA-binding transcription factor activity
LA59_20210	COG1686	Belongs to the peptidase S11 family
LA59_20240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA59_20245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA59_20260	COG0415	Belongs to the DNA photolyase family
LA59_20265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LA59_20275	COG4667	esterase of the alpha-beta hydrolase superfamily
LA59_20280	COG2095	MarC family integral membrane protein
LA59_20345	COG1301	dicarboxylic acid transport
LA59_20360	COG3339	Conserved Protein
LA59_20365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LA59_20370	COG0700	Nucleoside recognition
LA59_20375	COG3366	ferrous iron transmembrane transporter activity
LA59_20390	COG0366	Alpha amylase catalytic
LA59_20395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LA59_20400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LA59_20405	COG1640	4-alpha-glucanotransferase
LA59_20410	COG0058	SHG alpha-glucan phosphorylase activity
LA59_20430	COG1999	signal sequence binding
LA59_20440	COG1263	PTS System
LA59_20440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_20445	COG1162	GTPase activity
LA59_20450	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LA59_20455	COG0673	inositol 2-dehydrogenase activity
LA59_20480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_20485	COG0673	inositol 2-dehydrogenase activity
LA59_20490	COG3962	Belongs to the TPP enzyme family
LA59_20500	COG0477	Major facilitator Superfamily
LA59_20500	COG2814	Major facilitator Superfamily
LA59_20505	COG0583	DNA-binding transcription factor activity
LA59_20520	COG0183	Belongs to the thiolase family
LA59_20550	COG0531	amino acid
LA59_20555	COG1982	Orn Lys Arg decarboxylase major
LA59_20575	COG1929	Belongs to the glycerate kinase type-1 family
LA59_20580	COG3835	regulator
LA59_20585	COG1228	amidohydrolase
LA59_20645	COG1132	(ABC) transporter
LA59_20650	COG1132	(ABC) transporter
LA59_20655	COG4771	TonB-dependent receptor
LA59_20695	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LA59_20695	COG3408	Glycogen debranching enzyme
LA59_20715	COG2814	Major facilitator Superfamily
LA59_20735	COG3047	cAMP biosynthetic process
LA59_20740	COG1357	PFAM Pentapeptide repeats (8 copies)
LA59_20765	COG2076	Multidrug Resistance protein
LA59_20800	COG0583	DNA-binding transcription factor activity
LA59_20815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LA59_20835	COG3152	Membrane
LA59_20845	COG2199	diguanylate cyclase activity
LA59_20855	COG0561	phosphatase activity
LA59_20865	COG0564	pseudouridine synthase activity
LA59_20870	COG0534	Mate efflux family protein
LA59_20875	COG1609	Transcriptional regulator
LA59_20880	COG3842	ATPase activity
LA59_20885	COG2723	6-phospho-beta-galactosidase activity
LA59_20890	COG0395	ABC-type sugar transport system, permease component
LA59_20905	COG1609	Transcriptional regulator
LA59_20910	COG4580	involved in the transport of maltose and maltodextrins
LA59_20915	COG5001	Diguanylate cyclase
LA59_20980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LA59_21000	COG0191	fructose-bisphosphate aldolase activity
LA59_21010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_21015	COG3716	PTS system mannose fructose sorbose family IID component
LA59_21025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LA59_21030	COG2222	sugar isomerase
LA59_21040	COG1349	DNA-binding transcription factor activity
LA59_21045	COG1349	DNA-binding transcription factor activity
LA59_21055	COG1136	(ABC) transporter
LA59_21090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LA59_21095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LA59_21105	COG2259	Doxx family
LA59_21140	COG3623	hexulose-6-phosphate isomerase
LA59_21145	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
LA59_21150	COG0561	phosphatase activity
LA59_21210	COG0786	glutamate:sodium symporter activity
LA59_21215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA59_21220	COG1131	(ABC) transporter
LA59_21235	COG0786	glutamate:sodium symporter activity
LA59_21260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA59_21270	COG3279	Response regulator of the LytR AlgR family
LA59_21275	COG3275	phosphorelay sensor kinase activity
LA59_21295	COG1136	(ABC) transporter
LA59_21305	COG0583	DNA-binding transcription factor activity
LA59_21310	COG1566	PFAM secretion protein HlyD family protein
LA59_21320	COG0772	Belongs to the SEDS family
LA59_21345	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LA59_21345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LA59_21360	COG0444	Belongs to the ABC transporter superfamily
LA59_21365	COG4608	Belongs to the ABC transporter superfamily
LA59_21390	COG1444	tRNA N-acetyltransferase activity
LA59_21395	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LA59_21400	COG0848	biopolymer transport protein
LA59_21405	COG0811	peptide transport
LA59_21440	COG1595	DNA-templated transcription, initiation
LA59_21470	COG4166	transmembrane transport
LA59_21545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LA59_21595	COG1132	(ABC) transporter
LA59_21610	COG0517	IMP dehydrogenase activity
LA59_21610	COG0516	GMP reductase activity
LA59_21625	COG4580	involved in the transport of maltose and maltodextrins
LA59_21630	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LA59_21640	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LA59_21645	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_21650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_21655	COG0800	Aldolase
LA59_21670	COG3119	arylsulfatase activity
LA59_21675	COG2149	membrane
LA59_21705	COG0800	Aldolase
LA59_21710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_21715	COG1904	glucuronate isomerase
LA59_21720	COG0246	Mannitol dehydrogenase
LA59_21730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LA59_21740	COG2186	Transcriptional regulator
LA59_21745	COG1312	Catalyzes the dehydration of D-mannonate
LA59_21750	COG3655	Transcriptional regulator
LA59_21765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LA59_21770	COG1595	DNA-templated transcription, initiation
LA59_21780	COG0513	Belongs to the DEAD box helicase family
LA59_21785	COG3713	MltA-interacting MipA family protein
LA59_21795	COG2153	protein acetylation
LA59_21800	COG2258	MOSC domain
LA59_21815	COG1522	sequence-specific DNA binding
LA59_21835	COG0346	lactoylglutathione lyase activity
LA59_21880	COG0366	Alpha amylase catalytic
LA59_21885	COG0583	DNA-binding transcription factor activity
LA59_21910	COG3634	alkyl hydroperoxide reductase activity
LA59_21915	COG0450	alkyl hydroperoxide reductase
LA59_21920	COG1846	Transcriptional regulator
LA59_21925	COG1764	response to oxidative stress
LA59_21940	COG0840	transmembrane signaling receptor activity
LA59_21945	COG0612	Peptidase, M16
LA59_21970	COG0739	heme binding
LA59_21995	COG4604	ABC transporter, ATP-binding protein
LA59_22000	COG4605	iron ion homeostasis
LA59_22005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA59_22010	COG4607	ABC-type enterochelin transport system periplasmic component
LA59_22015	COG0583	DNA-binding transcription factor activity
LA59_22020	COG4771	TonB-dependent receptor
LA59_22040	COG2814	Major facilitator Superfamily
LA59_22055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA59_22060	COG2221	Nitrite and sulphite reductase 4Fe-4S
LA59_22080	COG2203	Gaf domain
LA59_22080	COG2199	diguanylate cyclase activity
LA59_22105	COG0366	Alpha amylase catalytic
LA59_22110	COG2356	endonuclease I
LA59_22115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA59_22160	COG0456	acetyltransferase
LA59_22195	COG3005	denitrification pathway
LA59_22200	COG0243	molybdopterin cofactor binding
LA59_22205	COG0671	phosphoesterase, PA-phosphatase related
LA59_22220	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LA59_22225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LA59_22230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LA59_22235	COG1116	anion transmembrane transporter activity
LA59_22240	COG0351	phosphomethylpyrimidine kinase
LA59_22245	COG0312	modulator of DNA gyrase
LA59_22250	COG0312	modulator of DNA gyrase
LA59_22310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA59_22320	COG0584	glycerophosphoryl diester phosphodiesterase
LA59_22330	COG0745	RESPONSE REGULATOR receiver
LA59_22350	COG0811	peptide transport
LA59_22355	COG0811	peptide transport
LA59_22360	COG0848	biopolymer transport protein
LA59_22405	COG0803	Belongs to the bacterial solute-binding protein 9 family
LA59_22410	COG1121	(ABC) transporter
LA59_22415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA59_22430	COG1770	oligopeptidase
LA59_22435	COG2814	Major facilitator Superfamily
LA59_22440	COG0010	Belongs to the arginase family
LA59_22445	COG1166	arginine decarboxylase activity
LA59_22455	COG0189	ligase activity
LA59_22455	COG4067	protein conserved in archaea
LA59_22460	COG0189	ligase activity
LA59_22485	COG0583	DNA-binding transcription factor activity
LA59_22525	COG1114	Component of the transport system for branched-chain amino acids
LA59_22545	COG0579	oxidoreductase
LA59_22560	COG3033	Beta-eliminating lyase
LA59_22575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LA59_22580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LA59_22600	COG3706	GGDEF domain
LA59_22615	COG3706	GGDEF domain
LA59_22620	COG0415	Belongs to the DNA photolyase family
LA59_22625	COG3046	protein related to deoxyribodipyrimidine photolyase
LA59_22635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA59_22635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LA59_22640	COG1765	OsmC-like protein
LA59_22690	COG1011	Hydrolase
LA59_22725	COG3240	lipase activity
LA59_22755	COG1609	Transcriptional regulator
LA59_22775	COG1840	ABC-type Fe3 transport system, periplasmic component
LA59_22780	COG3842	ATPase activity
LA59_22805	COG2990	Protein conserved in bacteria
LA59_22815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA59_22820	COG2866	Carboxypeptidase
LA59_22830	COG0583	DNA-binding transcription factor activity
LA59_22860	COG1760	l-serine dehydratase
LA59_22885	COG1388	LysM domain
LA59_22885	COG0741	lytic transglycosylase activity
LA59_22905	COG1815	bacterial-type flagellum-dependent cell motility
LA59_22910	COG1558	bacterial-type flagellum-dependent cell motility
LA59_22915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LA59_22920	COG1749	Flagellar hook protein flgE
LA59_22925	COG4787	bacterial-type flagellum-dependent cell motility
LA59_22930	COG4786	Flagellar basal body rod
LA59_22935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LA59_22940	COG1706	bacterial-type flagellum-dependent cell motility
LA59_22950	COG1256	bacterial-type flagellum assembly
LA59_22950	COG4786	Flagellar basal body rod
LA59_22955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_22990	COG2226	methyltransferase
LA59_23010	COG0672	)-iron permease
LA59_23035	COG1136	(ABC) transporter
LA59_23095	COG1360	Flagellar Motor Protein
LA59_23100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LA59_23105	COG1191	sigma factor activity
LA59_23110	COG1580	Controls the rotational direction of flagella during chemotaxis
LA59_23125	COG1516	flagellar protein fliS
LA59_23130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LA59_23140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LA59_23165	COG1987	bacterial-type flagellum assembly
LA59_23190	COG2204	response regulator
LA59_23205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LA59_23225	COG2200	EAL domain
LA59_23305	COG0346	lactoylglutathione lyase activity
LA59_23330	COG0745	RESPONSE REGULATOR receiver
LA59_23355	COG0156	8-amino-7-oxononanoate synthase activity
LA59_23360	COG1063	alcohol dehydrogenase
LA59_23395	COG1733	regulation of RNA biosynthetic process
LA59_23405	COG3338	carbonate dehydratase activity
LA59_23440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA59_23450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LA59_23490	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LA59_23500	COG0318	PFAM AMP-dependent synthetase and ligase
LA59_23505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_23535	COG0786	glutamate:sodium symporter activity
LA59_23540	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LA59_23550	COG1538	Outer membrane efflux protein
LA59_23560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_23565	COG0583	DNA-binding transcription factor activity
LA59_23580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LA59_23585	COG2197	response regulator
LA59_23595	COG0574	Belongs to the PEP-utilizing enzyme family
LA59_23595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA59_23605	COG0252	asparaginase activity
LA59_23620	COG0583	DNA-binding transcription factor activity
LA59_23645	COG3122	Protein conserved in bacteria
LA59_23660	COG1902	pentaerythritol trinitrate reductase activity
LA59_23670	COG2814	Major facilitator Superfamily
LA59_23675	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_23700	COG0583	DNA-binding transcription factor activity
LA59_23710	COG0513	Belongs to the DEAD box helicase family
LA59_23730	COG0095	Lipoate-protein ligase
LA59_23750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA59_23755	COG2207	Transcriptional regulator
LA59_23755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LA59_23760	COG0583	DNA-binding transcription factor activity
LA59_23770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA59_23795	COG3385	transposase activity
LA59_23810	COG1566	PFAM secretion protein HlyD family protein
LA59_23815	COG0583	DNA-binding transcription factor activity
LA59_23830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_23830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_23830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_23835	COG2207	Transcriptional regulator
LA59_23845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_23850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_23855	COG0583	DNA-binding transcription factor activity
LA59_23865	COG2084	Dehydrogenase
LA59_23870	COG0753	catalase activity
LA59_23880	COG2130	NADP-dependent
LA59_23885	COG1309	transcriptional regulator
LA59_23920	COG0438	transferase activity, transferring glycosyl groups
LA59_23930	COG3206	protein involved in exopolysaccharide biosynthesis
LA59_23930	COG0489	protein tyrosine kinase activity
LA59_23950	COG3842	ATPase activity
LA59_23960	COG1175	transmembrane transport
LA59_24010	COG0741	lytic transglycosylase activity
LA59_24035	COG2354	Protein conserved in bacteria
LA59_24045	COG0401	homolog of Blt101
LA59_24050	COG0633	Ferredoxin
LA59_24050	COG3217	Mosc domain protein beta barrel domain protein
LA59_24050	COG3217	Mosc domain protein beta barrel domain protein
LA59_24050	COG0633	Ferredoxin
LA59_24060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LA59_24100	COG0583	DNA-binding transcription factor activity
LA59_24120	COG2814	Major facilitator Superfamily
LA59_24125	COG1335	isochorismatase
LA59_24130	COG4977	sequence-specific DNA binding
LA59_24135	COG0673	inositol 2-dehydrogenase activity
LA59_24140	COG2194	sulfuric ester hydrolase activity
LA59_24145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LA59_24155	COG2205	protein histidine kinase activity
LA59_24160	COG0745	RESPONSE REGULATOR receiver
LA59_24165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA59_24170	COG4948	Mandelate Racemase Muconate Lactonizing
LA59_24175	COG1053	succinate dehydrogenase
LA59_24175	COG3976	FMN-binding domain protein
LA59_24190	COG4221	oxidoreductase activity
LA59_24205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA59_24225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LA59_24235	COG2814	Major facilitator Superfamily
LA59_24250	COG1418	mRNA catabolic process
LA59_24265	COG0402	S-adenosylhomocysteine deaminase activity
LA59_24270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LA59_24275	COG2239	Acts as a magnesium transporter
LA59_24280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LA59_24285	COG1566	PFAM secretion protein HlyD family protein
LA59_24310	COG0745	RESPONSE REGULATOR receiver
LA59_24315	COG2205	protein histidine kinase activity
LA59_24325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LA59_24330	COG0531	amino acid
LA59_24335	COG1522	sequence-specific DNA binding
LA59_24345	COG0583	DNA-binding transcription factor activity
LA59_24365	COG2205	protein histidine kinase activity
LA59_24365	COG5002	protein histidine kinase activity
LA59_24365	COG0784	Response regulator, receiver
LA59_24370	COG0673	inositol 2-dehydrogenase activity
LA59_24375	COG0534	Mate efflux family protein
LA59_24380	COG2926	Belongs to the UPF0265 family
LA59_24445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_24450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA59_24460	COG1280	lysine exporter protein (LysE YggA)
LA59_24470	COG0183	Belongs to the thiolase family
LA59_24490	COG3005	denitrification pathway
LA59_24510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA59_24515	COG3850	Histidine kinase
LA59_24520	COG2197	response regulator
LA59_24535	COG2195	Cleaves the N-terminal amino acid of tripeptides
LA59_24555	COG0840	transmembrane signaling receptor activity
LA59_24565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA59_24595	COG0545	Peptidyl-prolyl cis-trans isomerase
LA59_24605	COG2885	chlorophyll binding
LA59_24635	COG3152	Membrane
LA59_24685	COG1714	RDD family
LA59_24720	COG0747	negative chemotaxis
LA59_24725	COG0601	transmembrane transport
LA59_24730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LA59_24735	COG0444	Belongs to the ABC transporter superfamily
LA59_24740	COG4608	Belongs to the ABC transporter superfamily
LA59_24755	COG1278	Cold shock
LA59_24760	COG3036	rescue of stalled ribosome
LA59_24770	COG2199	diguanylate cyclase activity
LA59_24785	COG1136	(ABC) transporter
LA59_24785	COG0577	efflux transmembrane transporter activity
LA59_24790	COG1136	(ABC) transporter
LA59_24790	COG0577	efflux transmembrane transporter activity
LA59_24820	COG1538	Outer membrane efflux protein
LA59_24825	COG0784	Response regulator, receiver
LA59_24825	COG2205	protein histidine kinase activity
LA59_24850	COG0840	transmembrane signaling receptor activity
LA59_24855	COG0783	Belongs to the Dps family
LA59_24865	COG1619	proteins homologs of microcin C7 resistance protein MccF
LA59_24870	COG2133	pyrroloquinoline quinone binding
LA59_24875	COG1454	alcohol dehydrogenase
LA59_24885	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LA59_24905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LA59_24910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LA59_24920	COG3186	Phenylalanine-4-hydroxylase
LA59_24950	COG3530	Putative quorum-sensing-regulated virulence factor
LA59_24985	COG1289	transmembrane transporter activity
LA59_24990	COG0210	DNA helicase
LA59_25000	COG1879	ABC-type sugar transport system periplasmic component
LA59_25005	COG2205	protein histidine kinase activity
LA59_25005	COG2198	Histidine kinase
LA59_25005	COG0784	Response regulator, receiver
LA59_25035	COG3119	arylsulfatase activity
LA59_25040	COG3119	arylsulfatase activity
LA59_25050	COG0714	Associated with various cellular activities
LA59_25110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LA59_25120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LA59_25130	COG0583	DNA-binding transcription factor activity
LA59_25135	COG1597	lipid kinase activity
LA59_25140	COG3111	PFAM Bacterial OB fold (BOF) protein
LA59_25160	COG0641	radical SAM
LA59_25185	COG0501	Belongs to the peptidase M48B family
LA59_25190	COG1704	LemA family
LA59_25195	COG3069	C4-dicarboxylate transmembrane transporter activity
LA59_25225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LA59_25230	COG0739	heme binding
LA59_25255	COG2204	response regulator
LA59_25270	COG3501	Rhs element vgr protein
LA59_25295	COG0515	serine threonine protein kinase
LA59_25330	COG1522	sequence-specific DNA binding
LA59_25390	COG0457	Tetratricopeptide repeat
LA59_25395	COG0477	Major facilitator Superfamily
LA59_25395	COG2814	Major facilitator Superfamily
LA59_25400	COG1940	carbohydrate kinase activity
LA59_25405	COG2017	converts alpha-aldose to the beta-anomer
LA59_25410	COG0019	diaminopimelate decarboxylase activity
LA59_25415	COG4264	IucA IucC family
LA59_25440	COG4772	TonB-dependent receptor
LA59_25445	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LA59_25450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA59_25455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA59_25460	COG1120	ATPase activity
LA59_25465	COG4771	TonB-dependent receptor
LA59_25480	COG2205	protein histidine kinase activity
LA59_25480	COG0784	Response regulator, receiver
LA59_25485	COG3300	MHYT domain
LA59_25485	COG5001	Diguanylate cyclase
LA59_25490	COG2197	response regulator
LA59_25495	COG3706	GGDEF domain
LA59_25505	COG2197	response regulator
LA59_25515	COG0778	Nitroreductase
LA59_25525	COG0784	Response regulator, receiver
LA59_25525	COG0835	chemotaxis
LA59_25540	COG2962	Rard protein
LA59_25565	COG3278	Belongs to the heme-copper respiratory oxidase family
LA59_25590	COG1024	Enoyl-CoA hydratase
LA59_25595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LA59_25600	COG1960	acyl-CoA dehydrogenase activity
LA59_25610	COG0183	Belongs to the thiolase family
LA59_25625	COG1024	Enoyl-CoA hydratase
LA59_25630	COG1024	Enoyl-CoA hydratase
LA59_25640	COG1028	Short-chain dehydrogenase reductase Sdr
LA59_25650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LA59_25655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LA59_25660	COG1845	cytochrome c oxidase, subunit III
LA59_25665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LA59_25675	COG1902	pentaerythritol trinitrate reductase activity
LA59_25675	COG0446	pyridine nucleotide-disulphide oxidoreductase
LA59_25680	COG0671	phosphoesterase, PA-phosphatase related
LA59_25690	COG2076	Multidrug Resistance protein
LA59_25720	COG1132	(ABC) transporter
LA59_25735	COG1733	regulation of RNA biosynthetic process
LA59_25745	COG2176	DNA-directed DNA polymerase activity
LA59_25825	COG0509	glycine decarboxylation via glycine cleavage system
LA59_25830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LA59_25840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LA59_25850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_25855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA59_25885	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LA59_25885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_25885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LA59_25890	COG1105	Belongs to the carbohydrate kinase PfkB family
LA59_25895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_25895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LA59_25900	COG1609	Transcriptional regulator
LA59_25915	COG2199	diguanylate cyclase activity
LA59_25915	COG2200	EAL domain
LA59_25915	COG2203	Gaf domain
LA59_25920	COG0765	amino acid transport
LA59_25925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA59_25930	COG0765	amino acid transport
LA59_25935	COG1126	abc transporter atp-binding protein
LA59_25945	COG1979	alcohol dehydrogenase
LA59_25950	COG2207	Transcriptional regulator
LA59_25960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LA59_25970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LA59_25985	COG3437	response regulator, receiver
LA59_25985	COG0784	Response regulator, receiver
LA59_25990	COG0546	phosphoglycolate phosphatase activity
LA59_26005	COG0513	Belongs to the DEAD box helicase family
LA59_26010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LA59_26025	COG3038	cytochrome b561
LA59_26035	COG2116	formate transmembrane transporter activity
LA59_26045	COG0583	DNA-binding transcription factor activity
LA59_26055	COG3593	DNA synthesis involved in DNA repair
LA59_26060	COG0737	Belongs to the 5'-nucleotidase family
LA59_26085	COG1410	methionine synthase
LA59_26085	COG0646	methionine synthase
LA59_26100	COG2267	carboxylic ester hydrolase activity
LA59_26105	COG2067	long-chain fatty acid transport protein
LA59_26120	COG2050	protein possibly involved in aromatic compounds catabolism
LA59_26155	COG0484	heat shock protein binding
LA59_26165	COG3300	MHYT domain
LA59_26165	COG5001	Diguanylate cyclase
LA59_26170	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LA59_26180	COG4181	ATPase activity
LA59_26185	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LA59_26195	COG1984	allophanate hydrolase subunit 2
LA59_26200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LA59_26210	COG3447	MASE1 domain protein
LA59_26210	COG5001	Diguanylate cyclase
LA59_26210	COG5002	protein histidine kinase activity
LA59_26215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LA59_26225	COG0583	DNA-binding transcription factor activity
LA59_26235	COG0045	succinate-CoA ligase (ADP-forming) activity
LA59_26235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LA59_26235	COG1042	CoA-binding domain protein
LA59_26255	COG0023	Translation Initiation Factor
LA59_26260	COG2801	Transposase and inactivated derivatives
LA59_26335	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LA59_26340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LA59_26355	COG3706	GGDEF domain
LA59_26370	COG5001	Diguanylate cyclase
LA59_26370	COG4251	negative regulation of phosphorylation
LA59_26370	COG3706	GGDEF domain
LA59_26370	COG2203	Gaf domain
LA59_26380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LA59_26385	COG4149	molybdate abc transporter
LA59_26390	COG0725	ABC transporter, periplasmic molybdate-binding protein
LA59_26400	COG3111	PFAM Bacterial OB fold (BOF) protein
LA59_26410	COG4067	protein conserved in archaea
LA59_26410	COG0189	ligase activity
LA59_26425	COG0534	Mate efflux family protein
LA59_26430	COG0602	queuosine metabolic process
LA59_26435	COG1328	CTP reductase activity
LA59_26495	COG2197	response regulator
LA59_26500	COG3851	Histidine kinase
LA59_26505	COG2271	Major facilitator Superfamily
LA59_26510	COG1482	cell wall glycoprotein biosynthetic process
LA59_26520	COG0628	permease
LA59_26530	COG1566	PFAM secretion protein HlyD family protein
LA59_26555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LA59_26560	COG3118	belongs to the thioredoxin family
LA59_26565	COG2814	Major facilitator Superfamily
LA59_26605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LA59_26625	COG2116	formate transmembrane transporter activity
LA59_26630	COG2146	nitrite reductase [NAD(P)H] activity
LA59_26635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LA59_26640	COG5001	Diguanylate cyclase