locus-tag	class	description
LWM38_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LWM38_00010	COG0592	DNA-directed DNA polymerase activity
LWM38_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LWM38_00020	COG0187	DNA topoisomerase II activity
LWM38_00030	COG3977	Valine--pyruvate aminotransferase
LWM38_00035	COG0366	Alpha amylase catalytic
LWM38_00040	COG0751	glycine-tRNA ligase activity
LWM38_00045	COG0752	glycyl-tRNA synthetase alpha subunit
LWM38_00050	COG2119	membrane
LWM38_00060	COG0425	Belongs to the sulfur carrier protein TusA family
LWM38_00075	COG0604	alcohol dehydrogenase
LWM38_00080	COG0183	Belongs to the thiolase family
LWM38_00085	COG1024	Enoyl-CoA hydratase
LWM38_00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWM38_00090	COG1739	Uncharacterized protein family UPF0029
LWM38_00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LWM38_00140	COG2132	Multicopper oxidase
LWM38_00150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LWM38_00160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LWM38_00165	COG2104	thiamine diphosphate biosynthetic process
LWM38_00170	COG2022	thiamine diphosphate biosynthetic process
LWM38_00180	COG0006	proline dipeptidase activity
LWM38_00180	COG0006	proline dipeptidase activity
LWM38_00190	COG2814	Major facilitator Superfamily
LWM38_00210	COG3220	belongs to the UPF0276 family
LWM38_00220	COG0210	DNA helicase
LWM38_00230	COG0405	Gamma-glutamyltransferase
LWM38_00235	COG1280	lysine exporter protein (LysE YggA)
LWM38_00245	COG2962	Rard protein
LWM38_00250	COG0514	ATP-dependent DNA helicase (RecQ)
LWM38_00260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LWM38_00265	COG0248	Ppx GppA phosphatase
LWM38_00270	COG0513	Belongs to the DEAD box helicase family
LWM38_00275	COG3118	belongs to the thioredoxin family
LWM38_00290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LWM38_00295	COG2871	sodium ion transport
LWM38_00365	COG2959	enzyme of heme biosynthesis
LWM38_00370	COG1587	Uroporphyrinogen-III synthase
LWM38_00375	COG0181	hydroxymethylbilane synthase activity
LWM38_00385	COG1965	Belongs to the frataxin family
LWM38_00395	COG0019	diaminopimelate decarboxylase activity
LWM38_00400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LWM38_00410	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LWM38_00415	COG1011	Hydrolase
LWM38_00420	COG3287	FIST C domain
LWM38_00420	COG2200	EAL domain
LWM38_00420	COG2199	diguanylate cyclase activity
LWM38_00425	COG3148	PFAM DTW domain containing protein
LWM38_00440	COG0561	phosphatase activity
LWM38_00445	COG2267	carboxylic ester hydrolase activity
LWM38_00450	COG1280	lysine exporter protein (LysE YggA)
LWM38_00455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LWM38_00460	COG0640	Transcriptional regulator
LWM38_00465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LWM38_00500	COG2095	MarC family integral membrane protein
LWM38_00510	COG0742	ribosomal rna small subunit methyltransferase
LWM38_00515	COG0552	protein localization to endoplasmic reticulum
LWM38_00520	COG2884	Cell division ATP-binding protein ftsE
LWM38_00525	COG2177	Part of the ABC transporter FtsEX involved in
LWM38_00535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWM38_00540	COG0705	Rhomboid family
LWM38_00545	COG1580	Controls the rotational direction of flagella during chemotaxis
LWM38_00550	COG3161	chorismate lyase activity
LWM38_00555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LWM38_00560	COG2937	Belongs to the GPAT DAPAT family
LWM38_00565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LWM38_00570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LWM38_00575	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LWM38_00580	COG0534	Mate efflux family protein
LWM38_00585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LWM38_00610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LWM38_00625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LWM38_00720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LWM38_00730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LWM38_00740	COG1072	(Pantothenic acid kinase))
LWM38_00765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LWM38_00770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LWM38_00775	COG0250	Participates in transcription elongation, termination and antitermination
LWM38_00785	COG0081	regulation of translation
LWM38_00790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LWM38_00795	COG0222	ribosome binding
LWM38_00810	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LWM38_00815	COG2816	NAD+ diphosphatase activity
LWM38_00825	COG1573	uracil-dna glycosylase
LWM38_00835	COG3068	Protein conserved in bacteria
LWM38_00840	COG1253	flavin adenine dinucleotide binding
LWM38_00855	COG0151	Belongs to the GarS family
LWM38_00860	COG0138	bifunctional purine biosynthesis protein purh
LWM38_00870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LWM38_00875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LWM38_00880	COG2264	protein methyltransferase activity
LWM38_00885	COG0439	Biotin carboxylase
LWM38_00890	COG0511	ligase activity, forming carbon-carbon bonds
LWM38_00895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LWM38_00900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWM38_00915	COG2814	Major facilitator Superfamily
LWM38_00920	COG0784	Response regulator, receiver
LWM38_00920	COG2205	protein histidine kinase activity
LWM38_00920	COG2198	Histidine kinase
LWM38_00935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWM38_00945	COG3263	regulation of cellular component size
LWM38_00955	COG4232	protein-disulfide reductase activity
LWM38_00960	COG1438	arginine binding
LWM38_00965	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LWM38_00970	COG0540	Belongs to the ATCase OTCase family
LWM38_00975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LWM38_00980	COG0549	Belongs to the carbamate kinase family
LWM38_00990	COG1288	antiporter activity
LWM38_00995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LWM38_01000	COG1027	Aspartate ammonia-lyase
LWM38_01010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LWM38_01015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LWM38_01020	COG2205	protein histidine kinase activity
LWM38_01025	COG0745	RESPONSE REGULATOR receiver
LWM38_01035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LWM38_01045	COG0149	triose-phosphate isomerase activity
LWM38_01055	COG3152	Membrane
LWM38_01060	COG3344	reverse transcriptase
LWM38_01075	COG1494	fructose-1,6-bisphosphatase
LWM38_01080	COG3074	FtsZ-dependent cytokinesis
LWM38_01085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LWM38_01090	COG1575	Belongs to the MenA family. Type 1 subfamily
LWM38_01095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LWM38_01100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LWM38_01110	COG1609	Transcriptional regulator
LWM38_01115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LWM38_01120	COG0254	rRNA binding
LWM38_01125	COG0281	malic enzyme
LWM38_01130	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LWM38_01135	COG0626	cystathionine gamma-synthase activity
LWM38_01140	COG0527	aspartate kinase activity
LWM38_01140	COG0460	homoserine dehydrogenase
LWM38_01145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LWM38_01155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LWM38_01160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWM38_01165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LWM38_01180	COG0165	Argininosuccinate lyase
LWM38_01180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LWM38_01190	COG0251	oxidation-reduction process
LWM38_01195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LWM38_01200	COG0678	peroxiredoxin activity
LWM38_01200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LWM38_01210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LWM38_01245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LWM38_01255	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LWM38_01260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LWM38_01265	COG0546	phosphoglycolate phosphatase activity
LWM38_01270	COG0180	Tryptophanyl-tRNA synthetase
LWM38_01280	COG0512	Glutamine amidotransferase of anthranilate synthase
LWM38_01285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LWM38_01295	COG1012	belongs to the aldehyde dehydrogenase family
LWM38_01305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWM38_01310	COG3954	Phosphoribulokinase
LWM38_01315	COG3089	Belongs to the UPF0270 family
LWM38_01320	COG0429	hydrolase of the alpha beta-hydrolase fold
LWM38_01330	COG0488	(ABC) transporter
LWM38_01335	COG2249	NAD(P)H dehydrogenase (quinone) activity
LWM38_01340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LWM38_01340	COG0475	glutathione-regulated potassium exporter activity
LWM38_01350	COG1047	Peptidyl-prolyl cis-trans
LWM38_01355	COG1446	asparaginase
LWM38_01360	COG2900	Belongs to the SlyX family
LWM38_01370	COG0545	Peptidyl-prolyl cis-trans isomerase
LWM38_01375	COG2964	Protein conserved in bacteria
LWM38_01380	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LWM38_01385	COG2923	Belongs to the DsrF TusC family
LWM38_01405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LWM38_01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LWM38_01420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LWM38_01425	COG0088	Forms part of the polypeptide exit tunnel
LWM38_01430	COG0089	rRNA binding
LWM38_01435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LWM38_01440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LWM38_01450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LWM38_01455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LWM38_01465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LWM38_01470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LWM38_01475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LWM38_01480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LWM38_01485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LWM38_01490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LWM38_01495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LWM38_01505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LWM38_01510	COG1841	ribosomal large subunit assembly
LWM38_01515	COG0200	Binds to the 23S rRNA
LWM38_01520	COG0201	protein transport
LWM38_01525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LWM38_01530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LWM38_01535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LWM38_01540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LWM38_01545	COG0202	RNA polymerase activity
LWM38_01550	COG0203	ribosomal protein L17
LWM38_01560	COG0545	Peptidyl-prolyl cis-trans isomerase
LWM38_01565	COG3266	domain, Protein
LWM38_01565	COG3061	Opacity-associated protein A
LWM38_01575	COG2153	protein acetylation
LWM38_01605	COG0189	ligase activity
LWM38_01605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LWM38_01620	COG0175	sulfate reduction
LWM38_01625	COG2895	sulfate adenylyltransferase (ATP) activity
LWM38_01630	COG0471	metal ion transport
LWM38_01630	COG3273	potassium ion transport
LWM38_01635	COG0529	Catalyzes the synthesis of activated sulfate
LWM38_01670	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LWM38_01680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWM38_01685	COG0729	surface antigen
LWM38_01690	COG2911	Protein conserved in bacteria
LWM38_01695	COG2105	PFAM AIG2 family protein
LWM38_01700	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LWM38_01705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LWM38_01710	COG0163	prenyltransferase activity
LWM38_01715	COG4143	(ABC) transporter
LWM38_01720	COG1178	ABC-type Fe3 transport system permease component
LWM38_01725	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LWM38_01730	COG3028	Belongs to the UPF0307 family
LWM38_01735	COG0312	modulator of DNA gyrase
LWM38_01740	COG2239	Acts as a magnesium transporter
LWM38_01745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_01750	COG1660	Displays ATPase and GTPase activities
LWM38_01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_01760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LWM38_01770	COG1137	ATPase activity
LWM38_01775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LWM38_01785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LWM38_01790	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LWM38_01790	COG0517	IMP dehydrogenase activity
LWM38_01800	COG1127	ABC transporter
LWM38_01805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LWM38_01810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LWM38_01815	COG2854	intermembrane phospholipid transfer
LWM38_01825	COG5007	Belongs to the BolA IbaG family
LWM38_01830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LWM38_01835	COG0204	Acyl-transferase
LWM38_01840	COG0251	oxidation-reduction process
LWM38_01845	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LWM38_01875	COG0456	acetyltransferase
LWM38_01885	COG0525	valine-tRNA ligase activity
LWM38_01890	COG2927	DNA polymerase III (CHI subunit)
LWM38_01895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LWM38_01900	COG0795	lipopolysaccharide-transporting ATPase activity
LWM38_01905	COG0795	lipopolysaccharide-transporting ATPase activity
LWM38_01935	COG3547	Transposase (IS116 IS110 IS902 family)
LWM38_02010	COG5002	protein histidine kinase activity
LWM38_02010	COG0784	Response regulator, receiver
LWM38_02010	COG2205	protein histidine kinase activity
LWM38_02015	COG2203	Gaf domain
LWM38_02015	COG5001	Diguanylate cyclase
LWM38_02015	COG4251	negative regulation of phosphorylation
LWM38_02015	COG3706	GGDEF domain
LWM38_02135	COG0840	transmembrane signaling receptor activity
LWM38_02175	COG0741	lytic transglycosylase activity
LWM38_02180	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LWM38_02195	COG2066	Belongs to the glutaminase family
LWM38_02200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LWM38_02205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LWM38_02220	COG0762	integral membrane protein
LWM38_02225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LWM38_02230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LWM38_02245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LWM38_02250	COG1678	Uncharacterized ACR, COG1678
LWM38_02255	COG0189	ligase activity
LWM38_02260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LWM38_02265	COG2356	endonuclease I
LWM38_02270	COG3091	SprT-like family
LWM38_02280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LWM38_02290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LWM38_02295	COG0583	DNA-binding transcription factor activity
LWM38_02300	COG4771	TonB-dependent receptor
LWM38_02315	COG0191	fructose-bisphosphate aldolase activity
LWM38_02320	COG0668	transmembrane transport
LWM38_02335	COG1279	arginine transmembrane transporter activity
LWM38_02350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LWM38_02355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LWM38_02360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LWM38_02370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LWM38_02375	COG3079	Belongs to the UPF0149 family
LWM38_02380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWM38_02385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWM38_02395	COG0442	prolyl-tRNA aminoacylation
LWM38_02400	COG0354	folic acid binding
LWM38_02405	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LWM38_02410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LWM38_02415	COG1595	DNA-templated transcription, initiation
LWM38_02435	COG0481	GTPase activity
LWM38_02445	COG0571	ribonuclease III activity
LWM38_02450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LWM38_02455	COG1381	Involved in DNA repair and RecF pathway recombination
LWM38_02460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LWM38_02465	COG0736	holo-[acyl-carrier-protein] synthase activity
LWM38_02470	COG2205	protein histidine kinase activity
LWM38_02470	COG3437	response regulator, receiver
LWM38_02470	COG3850	Histidine kinase
LWM38_02470	COG4999	Histidine kinase
LWM38_02475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LWM38_02480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LWM38_02485	COG3956	TIGRFAM MazG family protein
LWM38_02490	COG0504	CTP synthase activity
LWM38_02495	COG0148	phosphopyruvate hydratase activity
LWM38_02500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LWM38_02505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LWM38_02515	COG0585	pseudouridine synthase activity
LWM38_02520	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LWM38_02525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LWM38_02535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LWM38_02540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LWM38_02545	COG1546	Belongs to the CinA family
LWM38_02550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LWM38_02565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LWM38_02620	COG3630	sodium ion export across plasma membrane
LWM38_02625	COG5016	pyruvate
LWM38_02625	COG0511	ligase activity, forming carbon-carbon bonds
LWM38_02630	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LWM38_02640	COG1238	metal cluster binding
LWM38_02645	COG0612	Peptidase, M16
LWM38_02660	COG1854	S-ribosylhomocysteine lyase activity
LWM38_02665	COG4536	flavin adenine dinucleotide binding
LWM38_02670	COG4137	Cytochrome C assembly protein
LWM38_02675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LWM38_02680	COG0228	four-way junction DNA binding
LWM38_02685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LWM38_02690	COG0336	Belongs to the RNA methyltransferase TrmD family
LWM38_02695	COG0335	large ribosomal subunit rRNA binding
LWM38_02705	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LWM38_02710	COG0237	dephospho-CoA kinase activity
LWM38_02720	COG1459	type II secretion system
LWM38_02725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LWM38_02735	COG0157	Belongs to the NadC ModD family
LWM38_02750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LWM38_02755	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWM38_02760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LWM38_02775	COG0288	reversible hydration of carbon dioxide
LWM38_02780	COG0659	secondary active sulfate transmembrane transporter activity
LWM38_02785	COG1131	(ABC) transporter
LWM38_02790	COG0842	Transport permease protein
LWM38_02795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LWM38_02800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LWM38_02805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LWM38_02815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LWM38_02825	COG1489	DNA binding
LWM38_02830	COG1643	Atp-dependent helicase
LWM38_02835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LWM38_02840	COG1752	Esterase of the alpha-beta hydrolase superfamily
LWM38_02845	COG1049	propionate catabolic process, 2-methylcitrate cycle
LWM38_02860	COG0004	ammonium transporteR
LWM38_02865	COG1840	ABC-type Fe3 transport system, periplasmic component
LWM38_02875	COG3842	ATPase activity
LWM38_02880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWM38_02895	COG2971	BadF BadG BcrA BcrD
LWM38_02905	COG4608	Belongs to the ABC transporter superfamily
LWM38_02910	COG0444	Belongs to the ABC transporter superfamily
LWM38_02915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWM38_02925	COG0747	negative chemotaxis
LWM38_02935	COG2813	Specifically methylates the guanine in position
LWM38_02940	COG0628	permease
LWM38_02945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LWM38_02950	COG0316	Belongs to the HesB IscA family
LWM38_02965	COG0739	heme binding
LWM38_02970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LWM38_02975	COG2239	Acts as a magnesium transporter
LWM38_02980	COG2027	D-alanyl-D-alanine carboxypeptidase
LWM38_02990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LWM38_02995	COG1534	Rna-binding protein
LWM38_03000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LWM38_03005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LWM38_03010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LWM38_03015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWM38_03020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LWM38_03035	COG0779	Required for maturation of 30S ribosomal subunits
LWM38_03040	COG0195	Participates in both transcription termination and antitermination
LWM38_03045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LWM38_03050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LWM38_03055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LWM38_03060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LWM38_03065	COG1185	polyribonucleotide nucleotidyltransferase activity
LWM38_03080	COG0534	Mate efflux family protein
LWM38_03085	COG0826	peptidase U32
LWM38_03090	COG0826	peptidase U32
LWM38_03100	COG3154	lipid carrier protein
LWM38_03105	COG3153	acetyltransferase
LWM38_03120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LWM38_03130	COG0084	hydrolase, TatD family'
LWM38_03135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LWM38_03140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LWM38_03145	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LWM38_03155	COG0813	purine-nucleoside phosphorylase activity
LWM38_03165	COG0560	Phosphoserine phosphatase
LWM38_03175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LWM38_03180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LWM38_03185	COG4628	conserved protein (DUF2132)
LWM38_03190	COG0583	DNA-binding transcription factor activity
LWM38_03200	COG1022	Amp-dependent synthetase and ligase
LWM38_03230	COG4964	Belongs to the GSP D family
LWM38_03290	COG2059	Chromate
LWM38_03295	COG0583	DNA-binding transcription factor activity
LWM38_03300	COG1757	Na H antiporter
LWM38_03305	COG1584	GPR1 FUN34 yaaH family protein
LWM38_03310	COG1115	amino acid carrier protein
LWM38_03335	COG4067	protein conserved in archaea
LWM38_03335	COG0189	ligase activity
LWM38_03350	COG2867	negative regulation of translational initiation
LWM38_03355	COG2914	Belongs to the UPF0125 (RnfH) family
LWM38_03360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LWM38_03365	COG0497	DNA recombination
LWM38_03370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LWM38_03375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LWM38_03380	COG1301	dicarboxylic acid transport
LWM38_03385	COG0443	Heat shock 70 kDa protein
LWM38_03390	COG0484	heat shock protein binding
LWM38_03420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LWM38_03435	COG0047	phosphoribosylformylglycinamidine synthase activity
LWM38_03435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LWM38_03440	COG2171	N-acyltransferase activity
LWM38_03445	COG2095	MarC family integral membrane protein
LWM38_03450	COG3141	response to X-ray
LWM38_03455	COG0583	DNA-binding transcription factor activity
LWM38_03465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LWM38_03470	COG1074	ATP-dependent DNA helicase activity
LWM38_03475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LWM38_03485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LWM38_03485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LWM38_03495	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LWM38_03500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LWM38_03505	COG2166	iron-sulfur cluster assembly
LWM38_03510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LWM38_03515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LWM38_03520	COG3248	Nucleoside-binding outer membrane protein
LWM38_03530	COG2211	Major facilitator Superfamily
LWM38_03535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LWM38_03545	COG2813	Specifically methylates the guanine in position
LWM38_03550	COG0271	Belongs to the BolA IbaG family
LWM38_03555	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LWM38_03560	COG1805	sodium ion transport
LWM38_03570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LWM38_03575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LWM38_03585	COG1477	protein flavinylation
LWM38_03590	COG2991	Protein conserved in bacteria
LWM38_03620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LWM38_03640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LWM38_03645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LWM38_03670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LWM38_03675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LWM38_03685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LWM38_03695	COG0733	neurotransmitter:sodium symporter activity
LWM38_03700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LWM38_03705	COG0321	lipoyl(octanoyl) transferase activity
LWM38_03715	COG1686	Belongs to the peptidase S11 family
LWM38_03720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LWM38_03725	COG0772	Belongs to the SEDS family
LWM38_03730	COG0768	penicillin binding
LWM38_03735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LWM38_03740	COG0799	negative regulation of ribosome biogenesis
LWM38_03745	COG1466	dna polymerase III delta subunit
LWM38_03750	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LWM38_03755	COG0495	leucyl-tRNA aminoacylation
LWM38_03760	COG2888	peptidyl-tyrosine sulfation
LWM38_03765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LWM38_03770	COG4535	Mg2 and Co2 transporter CorC
LWM38_03775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LWM38_03780	COG1702	phosphate starvation-inducible protein PhoH
LWM38_03790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LWM38_03795	COG2706	6-phosphogluconolactonase activity
LWM38_03900	COG0193	aminoacyl-tRNA hydrolase activity
LWM38_03905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LWM38_03910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LWM38_03915	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LWM38_03920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LWM38_03925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LWM38_03930	COG2890	protein-(glutamine-N5) methyltransferase activity
LWM38_03935	COG3094	Invasion gene expression up-regulator, SirB
LWM38_03940	COG2912	Transglutaminase-like superfamily
LWM38_03945	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LWM38_03955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LWM38_03960	COG1187	pseudouridine synthase activity
LWM38_03965	COG2840	Smr protein MutS2
LWM38_03995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWM38_04000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LWM38_04010	COG2217	Heavy metal translocating P-type atpase
LWM38_04010	COG2608	mercury ion transmembrane transporter activity
LWM38_04025	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_04060	COG2986	histidine ammonia-lyase
LWM38_04065	COG1216	Glycosyl transferase, family 2
LWM38_04085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LWM38_04090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LWM38_04155	COG0784	Response regulator, receiver
LWM38_04155	COG0835	chemotaxis
LWM38_04160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LWM38_04165	COG1815	bacterial-type flagellum-dependent cell motility
LWM38_04170	COG1558	bacterial-type flagellum-dependent cell motility
LWM38_04185	COG4787	bacterial-type flagellum-dependent cell motility
LWM38_04195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LWM38_04200	COG1706	bacterial-type flagellum-dependent cell motility
LWM38_04205	COG1705	Flagellar rod assembly protein muramidase FlgJ
LWM38_04205	COG3951	Flagellar rod assembly protein muramidase FlgJ
LWM38_04225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LWM38_04230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LWM38_04240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LWM38_04250	COG1516	flagellar protein fliS
LWM38_04270	COG1677	Flagellar hook-basal body complex protein FliE
LWM38_04280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LWM38_04330	COG1987	bacterial-type flagellum assembly
LWM38_04370	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LWM38_04375	COG0643	Histidine kinase
LWM38_04375	COG2198	Histidine kinase
LWM38_04375	COG0784	Response regulator, receiver
LWM38_04380	COG2201	protein-glutamate methylesterase activity
LWM38_04385	COG1192	Involved in chromosome partitioning
LWM38_04395	COG0835	chemotaxis
LWM38_04405	COG4133	protoheme IX ABC transporter activity
LWM38_04410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LWM38_04415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LWM38_04425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LWM38_04430	COG1138	Cytochrome C-type biogenesis protein
LWM38_04435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LWM38_04440	COG3088	subunit of a heme lyase
LWM38_04440	COG4235	cytochrome complex assembly
LWM38_04445	COG4235	cytochrome complex assembly
LWM38_04445	COG3088	subunit of a heme lyase
LWM38_04450	COG2853	Lipoprotein
LWM38_04460	COG2067	long-chain fatty acid transport protein
LWM38_04475	COG0183	Belongs to the thiolase family
LWM38_04480	COG1024	Enoyl-CoA hydratase
LWM38_04480	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWM38_04490	COG2062	phosphohistidine phosphatase, SixA
LWM38_04500	COG2890	protein-(glutamine-N5) methyltransferase activity
LWM38_04505	COG1280	lysine exporter protein (LysE YggA)
LWM38_04510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LWM38_04530	COG1175	transmembrane transport
LWM38_04540	COG3842	ATPase activity
LWM38_04545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LWM38_04550	COG2070	2-Nitropropane dioxygenase
LWM38_04550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LWM38_04565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LWM38_04565	COG3321	synthase
LWM38_04580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LWM38_04585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LWM38_04590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LWM38_04610	COG0544	peptidyl-prolyl cis-trans isomerase activity
LWM38_04615	COG0740	serine-type endopeptidase activity
LWM38_04620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LWM38_04625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LWM38_04630	COG0776	regulation of translation
LWM38_04635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWM38_04640	COG1555	photosystem II stabilization
LWM38_04655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LWM38_04660	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LWM38_04665	COG0436	Aminotransferase
LWM38_04675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LWM38_04680	COG2267	carboxylic ester hydrolase activity
LWM38_04705	COG2855	membrane
LWM38_04755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LWM38_04765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWM38_04770	COG2084	Dehydrogenase
LWM38_04780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LWM38_04785	COG1522	sequence-specific DNA binding
LWM38_04795	COG1946	Acyl-CoA thioesterase
LWM38_04800	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LWM38_04835	COG3730	PTS system glucitol sorbitol-specific
LWM38_04845	COG3731	PTS system glucitol sorbitol-specific IIA component
LWM38_04850	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_04860	COG1349	DNA-binding transcription factor activity
LWM38_04880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWM38_04900	COG3341	Caulimovirus viroplasmin
LWM38_04900	COG0328	RNA-DNA hybrid ribonuclease activity
LWM38_04905	COG0463	Glycosyl transferase, family 2
LWM38_04905	COG1216	Glycosyl transferase, family 2
LWM38_04915	COG0456	acetyltransferase
LWM38_04915	COG1214	PFAM Peptidase M22, glycoprotease
LWM38_04930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LWM38_04955	COG0069	glutamate synthase activity
LWM38_04985	COG1522	sequence-specific DNA binding
LWM38_04990	COG1280	lysine exporter protein (LysE YggA)
LWM38_05010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LWM38_05030	COG3040	lipid binding
LWM38_05035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LWM38_05040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWM38_05045	COG1845	cytochrome c oxidase, subunit III
LWM38_05050	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LWM38_05065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LWM38_05080	COG0517	IMP dehydrogenase activity
LWM38_05080	COG0617	tRNA 3'-terminal CCA addition
LWM38_05080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LWM38_05090	COG2217	Heavy metal translocating P-type atpase
LWM38_05110	COG0537	adenosine 5'-monophosphoramidase activity
LWM38_05135	COG3150	esterase
LWM38_05140	COG1252	NADH dehydrogenase
LWM38_05155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LWM38_05165	COG4591	ABC-type transport system involved in lipoprotein release permease component
LWM38_05170	COG1136	(ABC) transporter
LWM38_05175	COG4591	ABC-type transport system involved in lipoprotein release permease component
LWM38_05185	COG2333	competence protein COMEC
LWM38_05185	COG0658	competence protein
LWM38_05190	COG1132	(ABC) transporter
LWM38_05195	COG1663	tetraacyldisaccharide 4'-kinase activity
LWM38_05200	COG2835	tetraacyldisaccharide 4'-kinase activity
LWM38_05205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LWM38_05210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LWM38_05215	COG0539	negative regulation of cytoplasmic translation
LWM38_05220	COG0776	regulation of translation
LWM38_05225	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LWM38_05230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LWM38_05235	COG0284	orotidine-5'-phosphate decarboxylase activity
LWM38_05250	COG0583	DNA-binding transcription factor activity
LWM38_05260	COG0686	Belongs to the AlaDH PNT family
LWM38_05265	COG1522	sequence-specific DNA binding
LWM38_05275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LWM38_05280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LWM38_05285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LWM38_05290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LWM38_05295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LWM38_05300	COG0156	8-amino-7-oxononanoate synthase activity
LWM38_05310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LWM38_05320	COG0501	Belongs to the peptidase M48B family
LWM38_05325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LWM38_05330	COG2915	High frequency lysogenization protein hflD homolog
LWM38_05335	COG0482	sulfurtransferase activity
LWM38_05345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWM38_05350	COG2916	Histone family protein nucleoid-structuring protein H-NS
LWM38_05355	COG1757	Na H antiporter
LWM38_05370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LWM38_05375	COG0131	Imidazoleglycerol-phosphate dehydratase
LWM38_05375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LWM38_05380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LWM38_05385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LWM38_05390	COG0107	imidazoleglycerol-phosphate synthase activity
LWM38_05395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LWM38_05395	COG0140	phosphoribosyl-ATP diphosphatase activity
LWM38_05400	COG3012	SEC-C Motif Domain Protein
LWM38_05405	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LWM38_05410	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LWM38_05415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LWM38_05420	COG0215	cysteine-tRNA ligase activity
LWM38_05430	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LWM38_05450	COG3344	reverse transcriptase
LWM38_05455	COG0390	transport system, permease component
LWM38_05460	COG4459	periplasmic nitrate reductase
LWM38_05465	COG3005	denitrification pathway
LWM38_05470	COG0243	molybdopterin cofactor binding
LWM38_05480	COG1227	inorganic diphosphatase activity
LWM38_05495	COG4172	Belongs to the ABC transporter superfamily
LWM38_05510	COG4168	peptide transport system, permease
LWM38_05515	COG4166	transmembrane transport
LWM38_05520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LWM38_05525	COG1842	Phage shock protein A
LWM38_05535	COG1983	PspC domain protein
LWM38_05540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LWM38_05555	COG2818	Glycosylase
LWM38_05560	COG0626	cystathionine gamma-synthase activity
LWM38_05570	COG0733	neurotransmitter:sodium symporter activity
LWM38_05575	COG0564	pseudouridine synthase activity
LWM38_05580	COG0116	Belongs to the methyltransferase superfamily
LWM38_05580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LWM38_05585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LWM38_05590	COG4136	ATPase activity
LWM38_05595	COG4135	transport system, permease component
LWM38_05600	COG4134	Bacterial extracellular solute-binding protein
LWM38_05610	COG3313	Fe-S protein
LWM38_05630	COG0513	Belongs to the DEAD box helicase family
LWM38_05640	COG2866	Carboxypeptidase
LWM38_05660	COG4176	ABC-type proline glycine betaine transport system permease component
LWM38_05665	COG2113	Glycine betaine
LWM38_05675	COG3437	response regulator, receiver
LWM38_05755	COG0745	RESPONSE REGULATOR receiver
LWM38_05830	COG4122	O-methyltransferase activity
LWM38_05870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LWM38_05875	COG0642	Histidine kinase
LWM38_05890	COG1061	Type III restriction enzyme res subunit
LWM38_05900	COG2814	Major facilitator Superfamily
LWM38_05910	COG0702	epimerase
LWM38_05915	COG0534	Mate efflux family protein
LWM38_05920	COG1136	(ABC) transporter
LWM38_05940	COG3047	cAMP biosynthetic process
LWM38_05940	COG2885	chlorophyll binding
LWM38_05965	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LWM38_05970	COG2985	domain, Protein
LWM38_05970	COG3273	potassium ion transport
LWM38_05975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LWM38_05980	COG1737	Transcriptional regulator
LWM38_05985	COG0076	glutamate decarboxylase activity
LWM38_05995	COG2431	L-lysine efflux transmembrane transporter activity
LWM38_06005	COG3070	regulator of competence-specific genes
LWM38_06020	COG4191	Histidine kinase
LWM38_06030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LWM38_06050	COG1448	Aminotransferase
LWM38_06055	COG2770	Histidine kinase
LWM38_06055	COG3437	response regulator, receiver
LWM38_06065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWM38_06075	COG0017	Asparaginyl-tRNA synthetase
LWM38_06080	COG0840	transmembrane signaling receptor activity
LWM38_06085	COG0720	synthase
LWM38_06095	COG0583	DNA-binding transcription factor activity
LWM38_06100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LWM38_06105	COG0814	amino acid
LWM38_06110	COG1760	l-serine dehydratase
LWM38_06115	COG0814	amino acid
LWM38_06120	COG0494	nUDIX hydrolase
LWM38_06130	COG0784	Response regulator, receiver
LWM38_06130	COG5002	protein histidine kinase activity
LWM38_06135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LWM38_06150	COG3106	COG3106 Predicted ATPase
LWM38_06165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWM38_06175	COG5001	Diguanylate cyclase
LWM38_06185	COG0443	Heat shock 70 kDa protein
LWM38_06230	COG1643	Atp-dependent helicase
LWM38_06275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LWM38_06280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWM38_06280	COG0072	phenylalanine-tRNA ligase activity
LWM38_06315	COG2207	Transcriptional regulator
LWM38_06320	COG1522	sequence-specific DNA binding
LWM38_06325	COG2873	o-acetylhomoserine
LWM38_06335	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LWM38_06340	COG0583	DNA-binding transcription factor activity
LWM38_06360	COG1342	Belongs to the UPF0251 family
LWM38_06390	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LWM38_06410	COG0776	regulation of translation
LWM38_06455	COG2378	regulation of single-species biofilm formation
LWM38_06475	COG0583	DNA-binding transcription factor activity
LWM38_06495	COG0776	regulation of translation
LWM38_06505	COG0500	methyltransferase
LWM38_06510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LWM38_06515	COG0295	cytidine deaminase activity
LWM38_06520	COG1346	cytolysis
LWM38_06530	COG2925	Exonuclease
LWM38_06555	COG3568	Endonuclease Exonuclease Phosphatase
LWM38_06560	COG3122	Protein conserved in bacteria
LWM38_06565	COG1823	symporter activity
LWM38_06570	COG0702	epimerase
LWM38_06575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LWM38_06580	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LWM38_06585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LWM38_06605	COG2988	succinylglutamate desuccinylase activity
LWM38_06610	COG4139	cobalamin transport
LWM38_06615	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LWM38_06625	COG3321	synthase
LWM38_06625	COG0604	alcohol dehydrogenase
LWM38_06625	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_06645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWM38_06650	COG1271	oxidase subunit
LWM38_06655	COG1294	oxidase, subunit
LWM38_06665	COG1247	-acetyltransferase
LWM38_06685	COG2814	Major facilitator Superfamily
LWM38_06690	COG0583	DNA-binding transcription factor activity
LWM38_06700	COG1451	nucleotide metabolic process
LWM38_06710	COG3063	Type IV pilus biogenesis stability protein PilW
LWM38_06715	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LWM38_06730	COG2195	Cleaves the N-terminal amino acid of tripeptides
LWM38_06760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LWM38_06765	COG0583	DNA-binding transcription factor activity
LWM38_06770	COG0840	transmembrane signaling receptor activity
LWM38_06785	COG0454	-acetyltransferase
LWM38_06795	COG0420	3'-5' exonuclease activity
LWM38_06800	COG0419	ATPase involved in DNA repair
LWM38_06815	COG3046	protein related to deoxyribodipyrimidine photolyase
LWM38_06820	COG0589	response to stress
LWM38_06850	COG0494	nUDIX hydrolase
LWM38_06865	COG1187	pseudouridine synthase activity
LWM38_06890	COG0494	nUDIX hydrolase
LWM38_06915	COG0346	lactoylglutathione lyase activity
LWM38_06955	COG0653	protein targeting
LWM38_06960	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_06985	COG0826	peptidase U32
LWM38_07000	COG1126	abc transporter atp-binding protein
LWM38_07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWM38_07010	COG4215	(ABC) transporter
LWM38_07015	COG4160	amino acid transport
LWM38_07105	COG0582	viral genome integration into host DNA
LWM38_07125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWM38_07130	COG1902	pentaerythritol trinitrate reductase activity
LWM38_07130	COG0446	pyridine nucleotide-disulphide oxidoreductase
LWM38_07135	COG0583	DNA-binding transcription factor activity
LWM38_07150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LWM38_07165	COG0242	peptide deformylase activity
LWM38_07180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LWM38_07185	COG1215	transferase activity, transferring glycosyl groups
LWM38_07220	COG2204	response regulator
LWM38_07240	COG2885	chlorophyll binding
LWM38_07250	COG1793	dna ligase
LWM38_07255	COG0534	Mate efflux family protein
LWM38_07260	COG0307	riboflavin synthase, alpha
LWM38_07280	COG0791	NLP P60 protein
LWM38_07285	COG0840	transmembrane signaling receptor activity
LWM38_07295	COG3148	PFAM DTW domain containing protein
LWM38_07300	COG1940	carbohydrate kinase activity
LWM38_07310	COG0303	'Molybdopterin
LWM38_07315	COG0746	molybdenum cofactor guanylyltransferase activity
LWM38_07320	COG3842	ATPase activity
LWM38_07325	COG4662	Binding-protein-dependent transport system inner membrane component
LWM38_07340	COG4191	Histidine kinase
LWM38_07345	COG0840	transmembrane signaling receptor activity
LWM38_07360	COG0488	(ABC) transporter
LWM38_07365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LWM38_07395	COG0243	molybdopterin cofactor binding
LWM38_07395	COG3383	formate dehydrogenase (NAD+) activity
LWM38_07400	COG0437	4 iron, 4 sulfur cluster binding
LWM38_07415	COG0004	ammonium transporteR
LWM38_07420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LWM38_07425	COG3706	GGDEF domain
LWM38_07430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LWM38_07435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LWM38_07440	COG1177	transmembrane transport
LWM38_07450	COG3842	ATPase activity
LWM38_07470	COG0037	tRNA processing
LWM38_07475	COG0589	response to stress
LWM38_07480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWM38_07495	COG2217	Heavy metal translocating P-type atpase
LWM38_07505	COG2010	Cytochrome c
LWM38_07520	COG3278	Belongs to the heme-copper respiratory oxidase family
LWM38_07565	COG3120	sequence-specific DNA binding
LWM38_07570	COG1067	ATP-dependent peptidase activity
LWM38_07590	COG0488	(ABC) transporter
LWM38_07600	COG0116	Belongs to the methyltransferase superfamily
LWM38_07600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LWM38_07610	COG0167	dihydroorotate dehydrogenase activity
LWM38_07615	COG2902	Dehydrogenase
LWM38_07625	COG0308	aminopeptidase N
LWM38_07640	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LWM38_07645	COG1956	GAF domain-containing protein
LWM38_07650	COG1132	(ABC) transporter
LWM38_07655	COG2995	paraquat-inducible protein a
LWM38_07660	COG3008	intermembrane lipid transfer
LWM38_07665	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LWM38_07665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LWM38_07670	COG2996	Protein conserved in bacteria
LWM38_07685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LWM38_07685	COG0574	Belongs to the PEP-utilizing enzyme family
LWM38_07690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LWM38_07695	COG1666	GTP binding
LWM38_07705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWM38_07710	COG4597	amino acid ABC transporter
LWM38_07715	COG0765	amino acid transport
LWM38_07720	COG1126	abc transporter atp-binding protein
LWM38_07725	COG0670	Belongs to the BI1 family
LWM38_07730	COG2920	part of a sulfur-relay system
LWM38_07735	COG1254	Belongs to the acylphosphatase family
LWM38_07745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LWM38_07760	COG3047	cAMP biosynthetic process
LWM38_07760	COG2885	chlorophyll binding
LWM38_07775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LWM38_07780	COG0602	queuosine metabolic process
LWM38_07785	COG0561	phosphatase activity
LWM38_07805	COG2828	Protein conserved in bacteria
LWM38_07810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LWM38_07815	COG0372	Belongs to the citrate synthase family
LWM38_07820	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LWM38_07855	COG4628	conserved protein (DUF2132)
LWM38_07860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LWM38_07865	COG0363	glucosamine-6-phosphate deaminase activity
LWM38_07870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LWM38_07875	COG4565	transcriptional regulatory protein
LWM38_07880	COG3290	protein histidine kinase activity
LWM38_07895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LWM38_07910	COG1115	amino acid carrier protein
LWM38_07925	COG1115	amino acid carrier protein
LWM38_07945	COG1280	lysine exporter protein (LysE YggA)
LWM38_07950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LWM38_07960	COG1595	DNA-templated transcription, initiation
LWM38_07975	COG0730	response to heat
LWM38_08020	COG3033	Beta-eliminating lyase
LWM38_08045	COG0010	Belongs to the arginase family
LWM38_08050	COG1166	arginine decarboxylase activity
LWM38_08060	COG1309	transcriptional regulator
LWM38_08065	COG0488	(ABC) transporter
LWM38_08080	COG3097	Belongs to the UPF0267 family
LWM38_08085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LWM38_08090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LWM38_08110	COG4326	sporulation control protein
LWM38_08120	COG1228	amidohydrolase
LWM38_08125	COG0010	Belongs to the arginase family
LWM38_08130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LWM38_08135	COG2986	histidine ammonia-lyase
LWM38_08150	COG0247	lactate metabolic process
LWM38_08150	COG0277	FAD linked oxidase domain protein
LWM38_08165	COG2885	chlorophyll binding
LWM38_08190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LWM38_08200	COG1643	Atp-dependent helicase
LWM38_08205	COG0281	malic enzyme
LWM38_08210	COG2949	membrane
LWM38_08215	COG0471	metal ion transport
LWM38_08230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LWM38_08245	COG0492	ferredoxin-NADP+ reductase activity
LWM38_08250	COG4988	ABC transporter
LWM38_08255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LWM38_08265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWM38_08270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWM38_08295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LWM38_08310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWM38_08315	COG3108	Peptidase M15
LWM38_08320	COG2989	Protein conserved in bacteria
LWM38_08345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWM38_08355	COG3088	subunit of a heme lyase
LWM38_08355	COG4235	cytochrome complex assembly
LWM38_08365	COG1138	Cytochrome C-type biogenesis protein
LWM38_08370	COG3301	Polysulphide reductase, NrfD
LWM38_08375	COG0437	4 iron, 4 sulfur cluster binding
LWM38_08380	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LWM38_08385	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LWM38_08390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWM38_08410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWM38_08415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LWM38_08435	COG0243	molybdopterin cofactor binding
LWM38_08440	COG0437	4 iron, 4 sulfur cluster binding
LWM38_08445	COG3302	dmso reductase anchor subunit
LWM38_08465	COG0019	diaminopimelate decarboxylase activity
LWM38_08500	COG3344	reverse transcriptase
LWM38_08510	COG0322	excinuclease ABC activity
LWM38_08515	COG2197	response regulator
LWM38_08520	COG0417	DNA replication proofreading
LWM38_08530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LWM38_08545	COG1187	pseudouridine synthase activity
LWM38_08550	COG0009	L-threonylcarbamoyladenylate synthase
LWM38_08555	COG0613	PHP domain protein
LWM38_08565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LWM38_08570	COG0512	Glutamine amidotransferase of anthranilate synthase
LWM38_08575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LWM38_08580	COG0134	indole-3-glycerol-phosphate synthase activity
LWM38_08580	COG0135	phosphoribosylanthranilate isomerase activity
LWM38_08585	COG0133	tryptophan synthase activity
LWM38_08590	COG0159	tryptophan synthase activity
LWM38_08595	COG0330	HflC and HflK could
LWM38_08605	COG1301	dicarboxylic acid transport
LWM38_08610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWM38_08625	COG2917	probably involved in intracellular septation
LWM38_08630	COG1607	acyl-coa hydrolase
LWM38_08635	COG2350	Protein conserved in bacteria
LWM38_08645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LWM38_08665	COG1032	radical SAM domain protein
LWM38_08670	COG1396	sequence-specific DNA binding
LWM38_08675	COG3135	benzoate transporter
LWM38_08690	COG0463	Glycosyl transferase, family 2
LWM38_08695	COG0745	RESPONSE REGULATOR receiver
LWM38_08715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWM38_08720	COG0583	DNA-binding transcription factor activity
LWM38_08735	COG5002	protein histidine kinase activity
LWM38_08735	COG0784	Response regulator, receiver
LWM38_08750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LWM38_08755	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LWM38_08760	COG2885	chlorophyll binding
LWM38_08765	COG0823	Involved in the tonB-independent uptake of proteins
LWM38_08780	COG0811	peptide transport
LWM38_08785	COG0824	Thioesterase
LWM38_08795	COG4890	Cyd operon protein YbgT
LWM38_08800	COG1294	oxidase, subunit
LWM38_08805	COG1271	oxidase subunit
LWM38_08810	COG2255	four-way junction helicase activity
LWM38_08815	COG0632	four-way junction helicase activity
LWM38_08820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LWM38_08825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LWM38_08830	COG1801	Protein of unknown function DUF72
LWM38_08835	COG4106	trans-aconitate 2-methyltransferase activity
LWM38_08840	COG0500	methyltransferase
LWM38_08845	COG4067	protein conserved in archaea
LWM38_08845	COG0189	ligase activity
LWM38_08860	COG3383	formate dehydrogenase (NAD+) activity
LWM38_08865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LWM38_08870	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LWM38_08875	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LWM38_08880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LWM38_08885	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LWM38_08890	COG0745	RESPONSE REGULATOR receiver
LWM38_08895	COG3381	protein complex oligomerization
LWM38_08900	COG1609	Transcriptional regulator
LWM38_08905	COG3070	regulator of competence-specific genes
LWM38_08925	COG0297	glycogen (starch) synthase activity
LWM38_08930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LWM38_08935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LWM38_08945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LWM38_08955	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LWM38_08960	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LWM38_08965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LWM38_08970	COG0542	response to heat
LWM38_08975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LWM38_08980	COG1278	Cold shock
LWM38_08990	COG1187	pseudouridine synthase activity
LWM38_08995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LWM38_09005	COG1199	ATP-dependent helicase activity
LWM38_09025	COG2850	peptidyl-arginine hydroxylation
LWM38_09030	COG0840	transmembrane signaling receptor activity
LWM38_09035	COG2814	Major facilitator Superfamily
LWM38_09040	COG1770	oligopeptidase
LWM38_09050	COG4160	amino acid transport
LWM38_09075	COG1882	Formate acetyltransferase
LWM38_09085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LWM38_09090	COG3013	Belongs to the UPF0304 family
LWM38_09095	COG2766	serine protein kinase
LWM38_09100	COG2718	Belongs to the UPF0229 family
LWM38_09105	COG2719	SpoVR family
LWM38_09110	COG0616	signal peptide processing
LWM38_09115	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_09135	COG3344	reverse transcriptase
LWM38_09140	COG0835	chemotaxis
LWM38_09140	COG0784	Response regulator, receiver
LWM38_09145	COG1940	carbohydrate kinase activity
LWM38_09150	COG0469	pyruvate kinase activity
LWM38_09155	COG4667	esterase of the alpha-beta hydrolase superfamily
LWM38_09170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWM38_09170	COG1263	PTS System
LWM38_09175	COG0084	hydrolase, TatD family'
LWM38_09185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LWM38_09190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LWM38_09195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LWM38_09220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LWM38_09225	COG0416	fatty acid biosynthetic process
LWM38_09230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LWM38_09235	COG1399	metal-binding, possibly nucleic acid-binding protein
LWM38_09245	COG0564	pseudouridine synthase activity
LWM38_09250	COG1530	ribonuclease E activity
LWM38_09255	COG0659	secondary active sulfate transmembrane transporter activity
LWM38_09260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LWM38_09265	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LWM38_09270	COG2982	Protein involved in outer membrane biogenesis
LWM38_09275	COG0572	uridine kinase
LWM38_09280	COG0489	protein tyrosine kinase activity
LWM38_09285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWM38_09285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWM38_09295	COG2186	Transcriptional regulator
LWM38_09300	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LWM38_09310	COG0653	protein targeting
LWM38_09315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LWM38_09320	COG3706	GGDEF domain
LWM38_09330	COG3092	negative regulation of chromosome organization
LWM38_09335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LWM38_09340	COG0857	belongs to the CobB CobQ family
LWM38_09340	COG0280	phosphate acetyltransferase
LWM38_09345	COG0435	Glutathione S-transferase
LWM38_09355	COG0444	Belongs to the ABC transporter superfamily
LWM38_09360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWM38_09365	COG0601	transmembrane transport
LWM38_09375	COG0314	molybdopterin synthase activity
LWM38_09380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LWM38_09385	COG0315	cyclic pyranopterin monophosphate synthase activity
LWM38_09390	COG0521	Mo-molybdopterin cofactor biosynthetic process
LWM38_09395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LWM38_09400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LWM38_09405	COG2198	Histidine kinase
LWM38_09410	COG2204	response regulator
LWM38_09415	COG0556	nucleotide-excision repair
LWM38_09425	COG4657	Part of a membrane complex involved in electron transport
LWM38_09430	COG2878	Part of a membrane complex involved in electron transport
LWM38_09435	COG4656	Part of a membrane complex involved in electron transport
LWM38_09440	COG4658	electron transport chain
LWM38_09445	COG4659	FMN binding
LWM38_09450	COG4660	Part of a membrane complex involved in electron transport
LWM38_09455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LWM38_09460	COG0346	lactoylglutathione lyase activity
LWM38_09470	COG2885	chlorophyll binding
LWM38_09480	COG2056	Na+-H+ antiporter family
LWM38_09490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LWM38_09510	COG1012	belongs to the aldehyde dehydrogenase family
LWM38_09510	COG1454	alcohol dehydrogenase
LWM38_09515	COG2095	MarC family integral membrane protein
LWM38_09520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LWM38_09525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LWM38_09530	COG1757	Na H antiporter
LWM38_09545	COG3081	Nucleoid-associated protein
LWM38_09550	COG3082	Protein of unknown function (DUF1414)
LWM38_09555	COG3083	sulfuric ester hydrolase activity
LWM38_09565	COG0840	transmembrane signaling receptor activity
LWM38_09570	COG0123	including yeast histone deacetylase and acetoin utilization protein
LWM38_09585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LWM38_09590	COG0778	Nitroreductase
LWM38_09595	COG0446	pyridine nucleotide-disulphide oxidoreductase
LWM38_09595	COG1902	pentaerythritol trinitrate reductase activity
LWM38_09600	COG0616	signal peptide processing
LWM38_09605	COG0252	asparaginase activity
LWM38_09610	COG3139	Protein of unknown function (DUF1315)
LWM38_09620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWM38_09625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LWM38_09640	COG2226	methyltransferase
LWM38_09660	COG1785	Belongs to the alkaline phosphatase family
LWM38_09670	COG4251	negative regulation of phosphorylation
LWM38_09675	COG2197	response regulator
LWM38_09695	COG3706	GGDEF domain
LWM38_09720	COG2983	Belongs to the UPF0260 family
LWM38_09730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LWM38_09735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LWM38_09740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LWM38_09745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LWM38_09750	COG2832	Protein of unknown function (DUF454)
LWM38_09760	COG0745	RESPONSE REGULATOR receiver
LWM38_09765	COG0583	DNA-binding transcription factor activity
LWM38_09770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LWM38_09775	COG1286	toxin biosynthetic process
LWM38_09780	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LWM38_09785	COG0285	dihydrofolate synthase activity
LWM38_09790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LWM38_09795	COG0101	tRNA pseudouridine synthase activity
LWM38_09805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LWM38_09810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LWM38_09815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LWM38_09825	COG0431	NADPH-dependent FMN reductase
LWM38_09835	COG3101	peptidyl-lysine hydroxylation
LWM38_09840	COG2860	membrane
LWM38_09845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LWM38_09860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LWM38_09865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LWM38_09870	COG0583	DNA-binding transcription factor activity
LWM38_09875	COG2951	lytic endotransglycosylase activity
LWM38_09880	COG3100	YcgL domain-containing protein
LWM38_09885	COG0850	regulation of cytokinetic process
LWM38_09890	COG2894	cell division
LWM38_09895	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LWM38_09900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LWM38_09905	COG0318	PFAM AMP-dependent synthetase and ligase
LWM38_09910	COG0596	Alpha beta hydrolase
LWM38_09925	COG1214	PFAM Peptidase M22, glycoprotease
LWM38_09930	COG1199	ATP-dependent helicase activity
LWM38_09935	COG0788	formyltetrahydrofolate deformylase activity
LWM38_09940	COG3102	Protein conserved in bacteria
LWM38_09965	COG1918	ferrous iron import across plasma membrane
LWM38_09975	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LWM38_09980	COG1121	(ABC) transporter
LWM38_09985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LWM38_09995	COG0045	succinate-CoA ligase (ADP-forming) activity
LWM38_10000	COG0508	dehydrogenase complex catalyzes the overall conversion of
LWM38_10005	COG0567	Dehydrogenase, E1 component
LWM38_10010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LWM38_10015	COG1053	succinate dehydrogenase
LWM38_10020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LWM38_10030	COG0372	Belongs to the citrate synthase family
LWM38_10035	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LWM38_10045	COG0033	Phosphoglucomutase
LWM38_10050	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LWM38_10055	COG0596	Alpha beta hydrolase
LWM38_10080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LWM38_10085	COG2190	(PTS) system
LWM38_10085	COG1263	PTS System
LWM38_10085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWM38_10090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LWM38_10095	COG1846	Transcriptional regulator
LWM38_10095	COG1940	carbohydrate kinase activity
LWM38_10100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LWM38_10100	COG4651	solute:proton antiporter activity
LWM38_10105	COG0367	asparagine synthase
LWM38_10110	COG0250	Participates in transcription elongation, termination and antitermination
LWM38_10120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LWM38_10125	COG0563	adenylate kinase activity
LWM38_10130	COG0326	Molecular chaperone. Has ATPase activity
LWM38_10135	COG3710	Transcriptional regulator
LWM38_10155	COG0622	Phosphoesterase
LWM38_10180	COG1090	epimerase
LWM38_10185	COG0300	oxidoreductase activity
LWM38_10190	COG3118	belongs to the thioredoxin family
LWM38_10195	COG0330	HflC and HflK could
LWM38_10200	COG1585	Membrane protein implicated in regulation of membrane protease activity
LWM38_10205	COG0789	Transcriptional regulator
LWM38_10220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LWM38_10225	COG3115	cell septum assembly
LWM38_10230	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LWM38_10240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_10245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LWM38_10250	COG2190	(PTS) system
LWM38_10255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LWM38_10260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LWM38_10265	COG2837	iron assimilation
LWM38_10295	COG0189	ligase activity
LWM38_10305	COG1393	Belongs to the ArsC family
LWM38_10310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LWM38_10325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LWM38_10330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LWM38_10335	COG2716	regulation of RNA biosynthetic process
LWM38_10340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LWM38_10355	COG4783	chaperone-mediated protein folding
LWM38_10360	COG1393	Belongs to the ArsC family
LWM38_10380	COG2233	PERMEase
LWM38_10390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LWM38_10395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LWM38_10400	COG0121	glutamine amidotransferase
LWM38_10405	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LWM38_10410	COG1960	acyl-CoA dehydrogenase activity
LWM38_10420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LWM38_10425	COG0328	RNA-DNA hybrid ribonuclease activity
LWM38_10430	COG2226	methyltransferase
LWM38_10435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LWM38_10440	COG0741	lytic transglycosylase activity
LWM38_10440	COG1388	LysM domain
LWM38_10450	COG3021	interspecies interaction between organisms
LWM38_10455	COG0347	Belongs to the P(II) protein family
LWM38_10465	COG0037	tRNA processing
LWM38_10470	COG0825	malonyl-CoA metabolic process
LWM38_10475	COG0587	DNA-directed DNA polymerase activity
LWM38_10480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LWM38_10490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LWM38_10495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LWM38_10500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LWM38_10505	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LWM38_10515	COG0750	zinc metalloprotease
LWM38_10525	COG0575	Belongs to the CDS family
LWM38_10530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LWM38_10535	COG0233	cytoplasmic translational termination
LWM38_10540	COG0528	UMP kinase activity
LWM38_10545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LWM38_10550	COG0052	Belongs to the universal ribosomal protein uS2 family
LWM38_10555	COG0024	Methionine aminopeptidase
LWM38_10560	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LWM38_10570	COG0564	pseudouridine synthase activity
LWM38_10575	COG3098	single-species biofilm formation
LWM38_10595	COG1671	Belongs to the UPF0178 family
LWM38_10600	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LWM38_10610	COG0254	rRNA binding
LWM38_10615	COG1720	tRNA m6t6A37 methyltransferase activity
LWM38_10620	COG0442	prolyl-tRNA aminoacylation
LWM38_10675	COG0366	Alpha amylase catalytic
LWM38_10680	COG1263	PTS System
LWM38_10680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LWM38_10685	COG1609	Transcriptional regulator
LWM38_10695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LWM38_10700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LWM38_10705	COG2011	ABC-type metal ion transport system permease component
LWM38_10710	COG1464	Belongs to the NlpA lipoprotein family
LWM38_10715	COG4580	involved in the transport of maltose and maltodextrins
LWM38_10720	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LWM38_10730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LWM38_10730	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LWM38_10745	COG1611	Belongs to the LOG family
LWM38_10750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LWM38_10755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LWM38_10770	COG0583	DNA-binding transcription factor activity
LWM38_10775	COG0301	tRNA thio-modification
LWM38_10775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWM38_10785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LWM38_10790	COG1722	exodeoxyribonuclease VII activity
LWM38_10795	COG0142	geranyltranstransferase activity
LWM38_10800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LWM38_10810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LWM38_10815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LWM38_10820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LWM38_10840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LWM38_10840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LWM38_10845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LWM38_10850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LWM38_10855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LWM38_10865	COG1073	alpha beta
LWM38_10870	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LWM38_10875	COG2252	PERMEase
LWM38_10880	COG2195	Cleaves the N-terminal amino acid of tripeptides
LWM38_10910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LWM38_10915	COG1609	Transcriptional regulator
LWM38_10920	COG2017	converts alpha-aldose to the beta-anomer
LWM38_10930	COG1085	galactose-1-phosphate uridylyltransferase
LWM38_10935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LWM38_10940	COG1609	Transcriptional regulator
LWM38_10950	COG0519	Catalyzes the synthesis of GMP from XMP
LWM38_10950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LWM38_10955	COG0516	GMP reductase activity
LWM38_10955	COG0517	IMP dehydrogenase activity
LWM38_10965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LWM38_10980	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LWM38_10985	COG0804	urea catabolic process
LWM38_10990	COG0832	Belongs to the urease beta subunit family
LWM38_10995	COG0831	urea catabolic process
LWM38_11040	COG1160	GTP binding
LWM38_11045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LWM38_11050	COG2976	Protein conserved in bacteria
LWM38_11055	COG0124	histidyl-tRNA synthetase
LWM38_11060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LWM38_11070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LWM38_11075	COG0105	UTP biosynthetic process
LWM38_11080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LWM38_11085	COG2975	iron-sulfur cluster assembly
LWM38_11095	COG0443	Heat shock 70 kDa protein
LWM38_11100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LWM38_11110	COG0822	iron-sulfur transferase activity
LWM38_11115	COG1104	cysteine desulfurase activity
LWM38_11120	COG1959	2 iron, 2 sulfur cluster binding
LWM38_11125	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LWM38_11130	COG0483	inositol monophosphate 1-phosphatase activity
LWM38_11135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWM38_11140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWM38_11145	COG1862	Preprotein translocase
LWM38_11150	COG0343	queuine tRNA-ribosyltransferase activity
LWM38_11155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LWM38_11160	COG0517	IMP dehydrogenase activity
LWM38_11165	COG0840	transmembrane signaling receptor activity
LWM38_11170	COG0583	DNA-binding transcription factor activity
LWM38_11175	COG0450	alkyl hydroperoxide reductase
LWM38_11180	COG3142	Participates in the control of copper homeostasis
LWM38_11185	COG0704	Plays a role in the regulation of phosphate uptake
LWM38_11190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LWM38_11205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LWM38_11210	COG0248	Ppx GppA phosphatase
LWM38_11220	COG5002	protein histidine kinase activity
LWM38_11225	COG0745	RESPONSE REGULATOR receiver
LWM38_11230	COG2974	May be involved in recombination
LWM38_11235	COG0826	peptidase U32
LWM38_11240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LWM38_11245	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LWM38_11285	COG0542	response to heat
LWM38_11295	COG0564	pseudouridine synthase activity
LWM38_11300	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LWM38_11305	COG0741	lytic transglycosylase activity
LWM38_11310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LWM38_11315	COG0077	Prephenate dehydratase
LWM38_11315	COG1605	Chorismate mutase
LWM38_11320	COG5001	Diguanylate cyclase
LWM38_11325	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LWM38_11330	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LWM38_11340	COG0488	(ABC) transporter
LWM38_11350	COG0739	heme binding
LWM38_11355	COG0287	Prephenate dehydrogenase
LWM38_11355	COG1605	Chorismate mutase
LWM38_11360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LWM38_11365	COG1472	Belongs to the glycosyl hydrolase 3 family
LWM38_11370	COG1737	Transcriptional regulator
LWM38_11380	COG2971	BadF BadG BcrA BcrD
LWM38_11385	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LWM38_11390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LWM38_11400	COG1966	Carbon starvation protein
LWM38_11405	COG3275	phosphorelay sensor kinase activity
LWM38_11410	COG3279	Response regulator of the LytR AlgR family
LWM38_11415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LWM38_11420	COG1047	Peptidyl-prolyl cis-trans
LWM38_11430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LWM38_11435	COG0196	riboflavin kinase activity
LWM38_11440	COG0728	peptidoglycan biosynthetic process
LWM38_11445	COG0268	Binds directly to 16S ribosomal RNA
LWM38_11450	COG0640	Transcriptional regulator
LWM38_11455	COG0583	DNA-binding transcription factor activity
LWM38_11460	COG1283	sodium-dependent phosphate transmembrane transporter activity
LWM38_11465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LWM38_11470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LWM38_11475	COG0730	response to heat
LWM38_11485	COG0494	nUDIX hydrolase
LWM38_11520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LWM38_11525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LWM38_11530	COG4974	Belongs to the 'phage' integrase family
LWM38_11535	COG0716	FMN binding
LWM38_11545	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LWM38_11550	COG0513	Belongs to the DEAD box helicase family
LWM38_11555	COG3022	response to hydroperoxide
LWM38_11560	COG1115	amino acid carrier protein
LWM38_11575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LWM38_11580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LWM38_11585	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LWM38_11590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LWM38_11595	COG0083	homoserine kinase activity
LWM38_11610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LWM38_11615	COG0745	RESPONSE REGULATOR receiver
LWM38_11625	COG5002	protein histidine kinase activity
LWM38_11625	COG2198	Histidine kinase
LWM38_11625	COG0784	Response regulator, receiver
LWM38_11630	COG3706	GGDEF domain
LWM38_11630	COG4251	negative regulation of phosphorylation
LWM38_11630	COG5001	Diguanylate cyclase
LWM38_11630	COG2203	Gaf domain
LWM38_11635	COG1242	4 iron, 4 sulfur cluster binding
LWM38_11640	COG0067	glutamate synthase
LWM38_11640	COG0069	glutamate synthase activity
LWM38_11640	COG0070	glutamate synthase
LWM38_11650	COG0067	glutamate synthase
LWM38_11650	COG0069	glutamate synthase activity
LWM38_11650	COG0070	glutamate synthase
LWM38_11655	COG0493	'glutamate synthase
LWM38_11665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LWM38_11675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWM38_11680	COG2860	membrane
LWM38_11685	COG0583	DNA-binding transcription factor activity
LWM38_11690	COG0730	response to heat
LWM38_11695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LWM38_11700	COG0505	Belongs to the CarA family
LWM38_11705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LWM38_11710	COG0494	nUDIX hydrolase
LWM38_11715	COG0653	protein targeting
LWM38_11720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LWM38_11725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LWM38_11730	COG0849	cell division
LWM38_11735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LWM38_11740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LWM38_11745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LWM38_11750	COG0772	Belongs to the SEDS family
LWM38_11755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LWM38_11760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LWM38_11765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LWM38_11770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LWM38_11775	COG0768	penicillin binding
LWM38_11780	COG3116	cell division
LWM38_11785	COG0275	rRNA processing
LWM38_11795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LWM38_11810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LWM38_11820	COG3344	reverse transcriptase
LWM38_11825	COG2969	positive regulation of protein catabolic process
LWM38_11830	COG0625	glutathione transferase activity
LWM38_11835	COG2857	Cytochrome c1
LWM38_11840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LWM38_11845	COG0723	plastoquinol--plastocyanin reductase activity
LWM38_11850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LWM38_11860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LWM38_11865	COG3105	Protein conserved in bacteria
LWM38_11875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LWM38_11890	COG3150	esterase
LWM38_11900	COG3151	Protein conserved in bacteria
LWM38_11905	COG0494	nUDIX hydrolase
LWM38_11910	COG1538	Outer membrane efflux protein
LWM38_11915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LWM38_11915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LWM38_11920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LWM38_11930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LWM38_11935	COG3025	triphosphatase activity
LWM38_11940	COG1392	Phosphate transport regulator
LWM38_11945	COG0306	phosphate transporter
LWM38_11950	COG4991	sh3 domain protein
LWM38_11960	COG3409	Peptidoglycan-binding domain 1 protein
LWM38_11960	COG3267	Type II secretory pathway component ExeA
LWM38_11965	COG0617	tRNA 3'-terminal CCA addition
LWM38_11970	COG1968	undecaprenyl-diphosphatase activity
LWM38_11975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LWM38_11980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LWM38_11985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LWM38_11990	COG0596	Alpha beta hydrolase
LWM38_11995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LWM38_12000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LWM38_12005	COG1610	YqeY-like protein
LWM38_12040	COG0582	viral genome integration into host DNA
LWM38_12085	COG2873	o-acetylhomoserine
LWM38_12090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LWM38_12095	COG1349	DNA-binding transcription factor activity
LWM38_12100	COG0469	pyruvate kinase activity
LWM38_12110	COG0028	Belongs to the TPP enzyme family
LWM38_12115	COG1022	Amp-dependent synthetase and ligase
LWM38_12150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LWM38_12155	COG0473	3-isopropylmalate dehydrogenase activity
LWM38_12160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LWM38_12165	COG0066	3-isopropylmalate dehydratase activity
LWM38_12180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LWM38_12185	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LWM38_12190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWM38_12195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LWM38_12200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LWM38_12205	COG2967	ApaG domain
LWM38_12220	COG3610	response to peptide
LWM38_12225	COG2966	Psort location CytoplasmicMembrane, score
LWM38_12230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LWM38_12235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LWM38_12240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LWM38_12245	COG0142	geranyltranstransferase activity
LWM38_12255	COG0039	L-malate dehydrogenase activity
LWM38_12260	COG1438	arginine binding
LWM38_12275	COG0589	response to stress
LWM38_12280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LWM38_12285	COG0564	pseudouridine synthase activity
LWM38_12295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LWM38_12300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LWM38_12305	COG0312	modulator of DNA gyrase
LWM38_12310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LWM38_12325	COG0424	maF-like protein
LWM38_12330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LWM38_12335	COG1792	Involved in formation and maintenance of cell shape
LWM38_12340	COG1077	Cell shape determining protein MreB Mrl
LWM38_12370	COG2165	general secretion pathway protein
LWM38_12375	COG2165	general secretion pathway protein
LWM38_12385	COG1459	type II secretion system
LWM38_12390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LWM38_12400	COG3267	Type II secretory pathway component ExeA
LWM38_12400	COG3409	Peptidoglycan-binding domain 1 protein
LWM38_12425	COG2200	EAL domain
LWM38_12425	COG2199	diguanylate cyclase activity
LWM38_12430	COG0629	single-stranded DNA binding
LWM38_12435	COG2197	response regulator
LWM38_12445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LWM38_12455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LWM38_12460	COG0527	aspartate kinase activity
LWM38_12465	COG1410	methionine synthase
LWM38_12465	COG0646	methionine synthase
LWM38_12525	COG0175	sulfate reduction
LWM38_12530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWM38_12535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LWM38_12575	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LWM38_12695	COG0735	belongs to the Fur family
LWM38_12705	COG0166	Belongs to the GPI family
LWM38_12710	COG0432	Pfam Uncharacterised protein family UPF0047
LWM38_12715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LWM38_12730	COG0359	binds to the 23S rRNA
LWM38_12740	COG0360	Binds together with S18 to 16S ribosomal RNA
LWM38_12745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWM38_12750	COG0557	exoribonuclease II activity
LWM38_12755	COG0402	S-adenosylhomocysteine deaminase activity
LWM38_12760	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LWM38_12765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LWM38_12770	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LWM38_12775	COG0330	HflC and HflK could
LWM38_12780	COG0330	HflC and HflK could
LWM38_12785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LWM38_12790	COG1923	regulation of RNA biosynthetic process
LWM38_12795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LWM38_12800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LWM38_12805	COG0860	N-Acetylmuramoyl-L-alanine amidase
LWM38_12810	COG0802	atpase or kinase
LWM38_12815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LWM38_12900	COG1162	GTPase activity
LWM38_12910	COG0490	domain, Protein
LWM38_12910	COG0471	metal ion transport
LWM38_12925	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LWM38_12930	COG1053	succinate dehydrogenase
LWM38_12935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LWM38_12940	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LWM38_12950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LWM38_12955	COG1509	lysine 2,3-aminomutase activity
LWM38_12965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LWM38_12975	COG5001	Diguanylate cyclase
LWM38_12975	COG3300	MHYT domain
LWM38_12980	COG2197	response regulator
LWM38_12985	COG4251	negative regulation of phosphorylation
LWM38_12990	COG3706	GGDEF domain
LWM38_12995	COG5002	protein histidine kinase activity
LWM38_12995	COG5001	Diguanylate cyclase
LWM38_12995	COG3447	MASE1 domain protein
LWM38_13025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LWM38_13035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LWM38_13040	COG0534	Mate efflux family protein
LWM38_13045	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LWM38_13050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LWM38_13055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LWM38_13055	COG3153	acetyltransferase
LWM38_13080	COG0438	transferase activity, transferring glycosyl groups
LWM38_13085	COG0297	glycogen (starch) synthase activity
LWM38_13095	COG2244	polysaccharide biosynthetic process
LWM38_13110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LWM38_13140	COG2271	Major facilitator Superfamily
LWM38_13145	COG0584	glycerophosphoryl diester phosphodiesterase
LWM38_13160	COG1596	polysaccharide export
LWM38_13180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LWM38_13195	COG2895	sulfate adenylyltransferase (ATP) activity
LWM38_13205	COG0529	Catalyzes the synthesis of activated sulfate
LWM38_13210	COG0175	sulfate reduction
LWM38_13215	COG3273	potassium ion transport
LWM38_13215	COG0471	metal ion transport
LWM38_13220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LWM38_13245	COG0463	Glycosyl transferase, family 2
LWM38_13280	COG1682	transport, permease protein
LWM38_13295	COG0463	Glycosyl transferase, family 2
LWM38_13320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LWM38_13325	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LWM38_13330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LWM38_13335	COG1045	serine acetyltransferase
LWM38_13340	COG4942	peptidase
LWM38_13360	COG1560	Kdo2-lipid A biosynthetic process
LWM38_13375	COG2089	acid synthase
LWM38_13390	COG1083	cytidylyl-transferase
LWM38_13395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LWM38_13400	COG1086	Polysaccharide biosynthesis protein
LWM38_13405	COG0463	Glycosyl transferase, family 2
LWM38_13420	COG1519	Transferase
LWM38_13425	COG3642	lipopolysaccharide core region biosynthetic process
LWM38_13430	COG0859	PFAM glycosyl transferase family 9
LWM38_13440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LWM38_13450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LWM38_13455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LWM38_13460	COG2003	Belongs to the UPF0758 family
LWM38_13470	COG1309	transcriptional regulator
LWM38_13475	COG1560	Kdo2-lipid A biosynthetic process
LWM38_13480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LWM38_13485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LWM38_13490	COG1561	YicC-like family, N-terminal region
LWM38_13495	COG1278	Cold shock
LWM38_13505	COG2252	PERMEase
LWM38_13510	COG0194	GDP metabolic process
LWM38_13515	COG1758	RNA polymerase activity
LWM38_13520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LWM38_13525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LWM38_13540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LWM38_13555	COG1757	Na H antiporter
LWM38_13565	COG2183	response to ionizing radiation
LWM38_13575	COG0596	Alpha beta hydrolase
LWM38_13580	COG1040	competence protein
LWM38_13585	COG0316	Belongs to the HesB IscA family
LWM38_13585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LWM38_13590	COG0494	nUDIX hydrolase
LWM38_13595	COG1218	3'(2'),5'-bisphosphate nucleotidase
LWM38_13605	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LWM38_13610	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LWM38_13615	COG3156	type II secretion system protein K
LWM38_13620	COG4795	General secretion pathway protein
LWM38_13625	COG2165	general secretion pathway protein
LWM38_13630	COG2165	general secretion pathway protein
LWM38_13635	COG2165	general secretion pathway protein
LWM38_13640	COG1459	type II secretion system
LWM38_13645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LWM38_13655	COG3031	protein transport across the cell outer membrane
LWM38_13660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LWM38_13670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LWM38_13680	COG0456	acetyltransferase
LWM38_13685	COG1490	D-aminoacyl-tRNA deacylase activity
LWM38_13690	COG1295	ribonuclease BN
LWM38_13705	COG1217	gtp-binding protein TYPA
LWM38_13710	COG0174	glutamine synthetase
LWM38_13720	COG3852	Histidine kinase
LWM38_13745	COG3078	GTPase activator activity
LWM38_13770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LWM38_13770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LWM38_13785	COG0084	hydrolase, TatD family'
LWM38_13790	COG0805	protein transport
LWM38_13795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWM38_13800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LWM38_13805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LWM38_13810	COG3165	ubiquinone biosynthetic process from chorismate
LWM38_13815	COG2226	methyltransferase
LWM38_13820	COG1322	Protein conserved in bacteria
LWM38_13830	COG2081	HI0933 family
LWM38_13840	COG1528	Iron-storage protein
LWM38_13845	COG0589	response to stress
LWM38_13860	COG0742	ribosomal rna small subunit methyltransferase
LWM38_13865	COG5001	Diguanylate cyclase
LWM38_13865	COG5002	protein histidine kinase activity
LWM38_13870	COG1522	sequence-specific DNA binding
LWM38_13875	COG0339	signal peptide processing
LWM38_13880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LWM38_13885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LWM38_13895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LWM38_13900	COG0601	transmembrane transport
LWM38_13950	COG1309	transcriptional regulator
LWM38_13955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LWM38_13960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LWM38_13965	COG2960	long-chain fatty acid transporting porin activity
LWM38_13970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LWM38_13975	COG0583	DNA-binding transcription factor activity
LWM38_14020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LWM38_14030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LWM38_14035	COG0408	coproporphyrinogen oxidase activity
LWM38_14040	COG0009	L-threonylcarbamoyladenylate synthase
LWM38_14045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LWM38_14050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LWM38_14055	COG0551	DNA topoisomerase type I activity
LWM38_14060	COG2922	Belongs to the Smg family
LWM38_14065	COG0758	DNA mediated transformation
LWM38_14085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LWM38_14085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LWM38_14090	COG0569	domain protein
LWM38_14095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LWM38_14105	COG1272	protein, Hemolysin III
LWM38_14110	COG4326	sporulation control protein
LWM38_14120	COG3084	Protein conserved in bacteria
LWM38_14130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LWM38_14135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LWM38_14145	COG0606	chelatase, subunit chli
LWM38_14155	COG3978	acetolactate synthase activity
LWM38_14160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LWM38_14165	COG0129	dihydroxy-acid dehydratase activity
LWM38_14175	COG0583	DNA-binding transcription factor activity
LWM38_14180	COG2814	Major facilitator Superfamily
LWM38_14185	COG3706	GGDEF domain
LWM38_14195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LWM38_14200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LWM38_14205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LWM38_14210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LWM38_14215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LWM38_14220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LWM38_14235	COG3312	ion transport
LWM38_14240	COG1475	DNA binding
LWM38_14245	COG1192	Involved in chromosome partitioning
LWM38_14250	COG0357	Ribosomal RNA small subunit methyltransferase G
LWM38_14255	COG0445	tRNA wobble uridine modification
LWM38_14260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LWM38_14270	COG0706	membrane insertase activity
LWM38_14275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LWM38_14280	COG0594	ribonuclease P activity
LWM38_14285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LWM38_14290	COG1126	abc transporter atp-binding protein
LWM38_14305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWM38_14310	COG1621	beta-fructofuranosidase activity
LWM38_14325	COG3655	Transcriptional regulator
LWM38_14330	COG0625	glutathione transferase activity
LWM38_14340	COG3284	Transcriptional regulator
LWM38_14345	COG1012	belongs to the aldehyde dehydrogenase family
LWM38_14360	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LWM38_14365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LWM38_14390	COG4166	transmembrane transport
LWM38_14415	COG0840	transmembrane signaling receptor activity
LWM38_14420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWM38_14425	COG0697	spore germination
LWM38_14435	COG0583	DNA-binding transcription factor activity
LWM38_14450	COG0583	DNA-binding transcription factor activity
LWM38_14460	COG4948	Mandelate Racemase Muconate Lactonizing
LWM38_14470	COG2204	response regulator
LWM38_14485	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LWM38_14490	COG3639	organic phosphonate transmembrane transporter activity
LWM38_14495	COG3639	organic phosphonate transmembrane transporter activity
LWM38_14515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LWM38_14520	COG3047	cAMP biosynthetic process
LWM38_14530	COG1022	Amp-dependent synthetase and ligase
LWM38_14545	COG4221	oxidoreductase activity
LWM38_14550	COG0583	DNA-binding transcription factor activity
LWM38_14560	COG2910	NAD(P)H-binding
LWM38_14565	COG0583	DNA-binding transcription factor activity
LWM38_14575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWM38_14595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LWM38_14600	COG1901	pseudouridine methyltransferase
LWM38_14650	COG2194	sulfuric ester hydrolase activity
LWM38_14660	COG0534	Mate efflux family protein
LWM38_14670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LWM38_14675	COG2999	glutathione oxidoreductase activity
LWM38_14685	COG0673	inositol 2-dehydrogenase activity
LWM38_14700	COG0584	glycerophosphoryl diester phosphodiesterase
LWM38_14705	COG3842	ATPase activity
LWM38_14710	COG0395	ABC-type sugar transport system, permease component
LWM38_14740	COG4067	protein conserved in archaea
LWM38_14740	COG0189	ligase activity
LWM38_14745	COG0189	ligase activity
LWM38_14770	COG1120	ATPase activity
LWM38_14775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWM38_14785	COG4264	IucA IucC family
LWM38_14815	COG0564	pseudouridine synthase activity
LWM38_14825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LWM38_14825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LWM38_14875	COG4964	Belongs to the GSP D family
LWM38_14920	COG1131	(ABC) transporter
LWM38_14925	COG2186	Transcriptional regulator
LWM38_14940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LWM38_14945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_14950	COG3037	sugar-specific permease SgaT UlaA
LWM38_14970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LWM38_14995	COG0513	Belongs to the DEAD box helicase family
LWM38_15010	COG3706	GGDEF domain
LWM38_15015	COG1278	Cold shock
LWM38_15035	COG0531	amino acid
LWM38_15045	COG1280	lysine exporter protein (LysE YggA)
LWM38_15060	COG1151	hydroxylamine reductase activity
LWM38_15065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWM38_15075	COG2205	protein histidine kinase activity
LWM38_15075	COG0784	Response regulator, receiver
LWM38_15075	COG5002	protein histidine kinase activity
LWM38_15080	COG2926	Belongs to the UPF0265 family
LWM38_15090	COG3132	Protein of unknown function, DUF480
LWM38_15095	COG2827	Endonuclease containing a URI domain
LWM38_15125	COG0443	Heat shock 70 kDa protein
LWM38_15135	COG0179	Fumarylacetoacetate (FAA) hydrolase
LWM38_15140	COG1280	lysine exporter protein (LysE YggA)
LWM38_15145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWM38_15155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LWM38_15165	COG1845	cytochrome c oxidase, subunit III
LWM38_15185	COG1612	heme a metabolic process
LWM38_15190	COG0109	protoheme IX farnesyltransferase activity
LWM38_15200	COG3530	Putative quorum-sensing-regulated virulence factor
LWM38_15205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LWM38_15210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LWM38_15220	COG0668	transmembrane transport
LWM38_15225	COG0569	domain protein
LWM38_15230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LWM38_15235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWM38_15235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LWM38_15240	COG1765	OsmC-like protein
LWM38_15245	COG2885	chlorophyll binding
LWM38_15255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LWM38_15265	COG1840	ABC-type Fe3 transport system, periplasmic component
LWM38_15270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWM38_15280	COG3842	ATPase activity
LWM38_15300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LWM38_15310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LWM38_15315	COG3265	gluconokinase activity
LWM38_15320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LWM38_15325	COG1609	Transcriptional regulator
LWM38_15330	COG2375	cellular response to nickel ion
LWM38_15335	COG1760	l-serine dehydratase
LWM38_15360	COG1132	(ABC) transporter
LWM38_15365	COG1132	(ABC) transporter
LWM38_15385	COG0393	Putative heavy-metal-binding
LWM38_15400	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LWM38_15405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LWM38_15430	COG0583	DNA-binding transcription factor activity
LWM38_15440	COG0156	8-amino-7-oxononanoate synthase activity
LWM38_15445	COG1063	alcohol dehydrogenase
LWM38_15455	COG1454	alcohol dehydrogenase
LWM38_15465	COG1011	Hydrolase
LWM38_15490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LWM38_15495	COG1328	CTP reductase activity
LWM38_15500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LWM38_15505	COG0583	DNA-binding transcription factor activity
LWM38_15525	COG1289	transmembrane transporter activity
LWM38_15530	COG0210	DNA helicase
LWM38_15540	COG1803	Methylglyoxal synthase
LWM38_15545	COG1879	ABC-type sugar transport system periplasmic component
LWM38_15550	COG0784	Response regulator, receiver
LWM38_15550	COG2198	Histidine kinase
LWM38_15550	COG5002	protein histidine kinase activity
LWM38_15575	COG0625	glutathione transferase activity
LWM38_15595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LWM38_15605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LWM38_15605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LWM38_15605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LWM38_15610	COG1105	Belongs to the carbohydrate kinase PfkB family
LWM38_15615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_15615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_15620	COG1609	Transcriptional regulator
LWM38_15625	COG2815	serine threonine protein kinase
LWM38_15625	COG0515	serine threonine protein kinase
LWM38_15630	COG2223	nitrite transmembrane transporter activity
LWM38_15640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWM38_15645	COG0243	molybdopterin cofactor binding
LWM38_15750	COG1609	Transcriptional regulator
LWM38_15755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWM38_15760	COG1879	ABC-type sugar transport system periplasmic component
LWM38_15765	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWM38_15770	COG1129	ABC transporter
LWM38_15775	COG1869	D-ribose catabolic process
LWM38_15790	COG4166	transmembrane transport
LWM38_15795	COG4174	ABC transporter (Permease)
LWM38_15800	COG4239	(ABC) transporter, permease
LWM38_15805	COG4172	Belongs to the ABC transporter superfamily
LWM38_15815	COG0583	DNA-binding transcription factor activity
LWM38_15825	COG1012	belongs to the aldehyde dehydrogenase family
LWM38_15835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWM38_15865	COG0384	phenazine biosynthesis protein PhzF
LWM38_15875	COG0454	-acetyltransferase
LWM38_15880	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LWM38_15885	COG0456	acetyltransferase
LWM38_15890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LWM38_15895	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LWM38_15910	COG3119	arylsulfatase activity
LWM38_15915	COG3119	arylsulfatase activity
LWM38_15925	COG0714	Associated with various cellular activities
LWM38_15960	COG1597	lipid kinase activity
LWM38_15970	COG0641	radical SAM
LWM38_15980	COG5002	protein histidine kinase activity
LWM38_15980	COG2205	protein histidine kinase activity
LWM38_15980	COG0784	Response regulator, receiver
LWM38_15995	COG1132	(ABC) transporter
LWM38_16000	COG1538	Outer membrane efflux protein
LWM38_16010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LWM38_16030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LWM38_16075	COG0745	RESPONSE REGULATOR receiver
LWM38_16085	COG1881	PFAM PEBP family protein
LWM38_16125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LWM38_16280	COG0242	peptide deformylase activity
LWM38_16290	COG1278	Cold shock
LWM38_16305	COG0582	viral genome integration into host DNA
LWM38_16340	COG3344	reverse transcriptase
LWM38_16420	COG0500	methyltransferase
LWM38_16435	COG0509	glycine decarboxylation via glycine cleavage system
LWM38_16465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LWM38_16470	COG3706	GGDEF domain
LWM38_16475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LWM38_16480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWM38_16555	COG0814	amino acid
LWM38_16560	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LWM38_16565	COG0513	Belongs to the DEAD box helicase family
LWM38_16570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LWM38_16575	COG1012	belongs to the aldehyde dehydrogenase family
LWM38_16580	COG1522	sequence-specific DNA binding
LWM38_16585	COG3608	succinylglutamate desuccinylase aspartoacylase
LWM38_16590	COG0006	proline dipeptidase activity
LWM38_16625	COG3038	cytochrome b561
LWM38_16630	COG2353	YceI-like domain
LWM38_16635	COG2116	formate transmembrane transporter activity
LWM38_16640	COG0583	DNA-binding transcription factor activity
LWM38_16650	COG3593	DNA synthesis involved in DNA repair
LWM38_16655	COG0737	Belongs to the 5'-nucleotidase family
LWM38_16660	COG0861	Integral membrane protein TerC family
LWM38_16670	COG0513	Belongs to the DEAD box helicase family
LWM38_16680	COG1566	PFAM secretion protein HlyD family protein
LWM38_16690	COG0583	DNA-binding transcription factor activity
LWM38_16700	COG2267	carboxylic ester hydrolase activity
LWM38_16705	COG2067	long-chain fatty acid transport protein
LWM38_16715	COG0501	Belongs to the peptidase M48B family
LWM38_16720	COG2050	protein possibly involved in aromatic compounds catabolism
LWM38_16730	COG4533	DNA binding
LWM38_16755	COG0484	heat shock protein binding
LWM38_16760	COG0768	penicillin binding
LWM38_16770	COG1716	ATPase activity
LWM38_16770	COG5001	Diguanylate cyclase
LWM38_16775	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LWM38_16785	COG4181	ATPase activity
LWM38_16790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LWM38_16800	COG1984	allophanate hydrolase subunit 2
LWM38_16805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LWM38_16820	COG1629	transport
LWM38_16820	COG4771	TonB-dependent receptor
LWM38_16825	COG0583	DNA-binding transcription factor activity
LWM38_16830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWM38_16830	COG1042	CoA-binding domain protein
LWM38_16830	COG0045	succinate-CoA ligase (ADP-forming) activity
LWM38_16835	COG3266	domain, Protein
LWM38_16840	COG1181	Belongs to the D-alanine--D-alanine ligase family
LWM38_16855	COG0023	Translation Initiation Factor
LWM38_16870	COG3140	Belongs to the UPF0181 family
LWM38_16895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LWM38_16900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LWM38_16915	COG3706	GGDEF domain
LWM38_16925	COG4251	negative regulation of phosphorylation
LWM38_16925	COG5001	Diguanylate cyclase
LWM38_16925	COG3706	GGDEF domain
LWM38_16925	COG2203	Gaf domain
LWM38_16935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LWM38_16940	COG4149	molybdate abc transporter
LWM38_16945	COG0725	ABC transporter, periplasmic molybdate-binding protein
LWM38_16965	COG0488	(ABC) transporter
LWM38_16970	COG4067	protein conserved in archaea
LWM38_16970	COG0189	ligase activity
LWM38_16985	COG0534	Mate efflux family protein
LWM38_16990	COG0602	queuosine metabolic process
LWM38_16995	COG1328	CTP reductase activity
LWM38_17025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LWM38_17030	COG3118	belongs to the thioredoxin family
LWM38_17045	COG0477	Major facilitator Superfamily
LWM38_17055	COG0534	Mate efflux family protein
LWM38_17080	COG1321	iron dependent repressor
LWM38_17080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LWM38_17085	COG1121	(ABC) transporter
LWM38_17090	COG0803	Belongs to the bacterial solute-binding protein 9 family
LWM38_17135	COG0848	biopolymer transport protein
LWM38_17140	COG0811	peptide transport
LWM38_17145	COG0811	peptide transport
LWM38_17155	COG4774	siderophore transport
LWM38_17160	COG1301	dicarboxylic acid transport
LWM38_17165	COG2205	protein histidine kinase activity
LWM38_17170	COG0745	RESPONSE REGULATOR receiver
LWM38_17185	COG1648	precorrin-2 dehydrogenase activity
LWM38_17185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LWM38_17190	COG2116	formate transmembrane transporter activity
LWM38_17200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LWM38_17220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LWM38_17280	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LWM38_17290	COG0494	nUDIX hydrolase
LWM38_17295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LWM38_17350	COG3706	GGDEF domain
LWM38_17355	COG3069	C4-dicarboxylate transmembrane transporter activity
LWM38_17360	COG2197	response regulator
LWM38_17365	COG3850	Histidine kinase
LWM38_17380	COG0243	molybdopterin cofactor binding
LWM38_17390	COG3005	denitrification pathway
LWM38_17400	COG3243	poly(R)-hydroxyalkanoic acid synthase
LWM38_17410	COG0183	Belongs to the thiolase family
LWM38_17465	COG0513	Belongs to the DEAD box helicase family
LWM38_17470	COG0523	cobalamin synthesis protein
LWM38_17475	COG0038	chloride channel
LWM38_17485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWM38_17485	COG1017	nitric oxide dioxygenase activity
LWM38_17490	COG3604	Transcriptional regulator
LWM38_17510	COG0545	Peptidyl-prolyl cis-trans isomerase
LWM38_17515	COG1309	transcriptional regulator
LWM38_17520	COG2130	NADP-dependent
LWM38_17530	COG0564	pseudouridine synthase activity
LWM38_17540	COG1686	Belongs to the peptidase S11 family
LWM38_17560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWM38_17570	COG3059	membrane
LWM38_17585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LWM38_17605	COG2207	Transcriptional regulator
LWM38_17610	COG1979	alcohol dehydrogenase
LWM38_17615	COG1126	abc transporter atp-binding protein
LWM38_17620	COG0765	amino acid transport
LWM38_17625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LWM38_17630	COG0765	amino acid transport
LWM38_17655	COG2824	Alkylphosphonate utilization operon protein PhnA
LWM38_17690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LWM38_17695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LWM38_17710	COG0446	pyridine nucleotide-disulphide oxidoreductase
LWM38_17710	COG1902	pentaerythritol trinitrate reductase activity
LWM38_17715	COG1250	3-hydroxyacyl-CoA dehydrogenase
LWM38_17715	COG1024	Enoyl-CoA hydratase
LWM38_17730	COG4774	siderophore transport
LWM38_17740	COG2814	Major facilitator Superfamily
LWM38_17745	COG2133	pyrroloquinoline quinone binding
LWM38_17750	COG1278	Cold shock
LWM38_17755	COG4681	YaeQ
LWM38_17765	COG0302	gtp cyclohydrolase
LWM38_17785	COG2897	thiosulfate sulfurtransferase activity
LWM38_17790	COG5001	Diguanylate cyclase
LWM38_17790	COG2203	Gaf domain
LWM38_17790	COG3706	GGDEF domain
LWM38_17790	COG4251	negative regulation of phosphorylation
LWM38_17845	COG4964	Belongs to the GSP D family
LWM38_17885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LWM38_17890	COG0840	transmembrane signaling receptor activity
LWM38_17915	COG2814	Major facilitator Superfamily
LWM38_17920	COG0583	DNA-binding transcription factor activity
LWM38_17925	COG4604	ABC transporter, ATP-binding protein
LWM38_17930	COG4605	iron ion homeostasis
LWM38_17935	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWM38_17940	COG4607	ABC-type enterochelin transport system periplasmic component
LWM38_17960	COG0583	DNA-binding transcription factor activity
LWM38_17975	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LWM38_17980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LWM38_17985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LWM38_17990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LWM38_17995	COG1116	anion transmembrane transporter activity
LWM38_18000	COG0351	phosphomethylpyrimidine kinase
LWM38_18005	COG0697	spore germination
LWM38_18050	COG0516	GMP reductase activity
LWM38_18070	COG0534	Mate efflux family protein
LWM38_18075	COG0583	DNA-binding transcription factor activity
LWM38_18080	COG0366	Alpha amylase catalytic
LWM38_18095	COG1132	(ABC) transporter
LWM38_18100	COG4774	siderophore transport
LWM38_18105	COG1120	ATPase activity
LWM38_18140	COG0113	porphobilinogen synthase activity
LWM38_18160	COG3344	reverse transcriptase
LWM38_18170	COG0154	amidase activity
LWM38_18180	COG4974	Belongs to the 'phage' integrase family
LWM38_18200	COG1335	isochorismatase
LWM38_18220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWM38_18245	COG0583	DNA-binding transcription factor activity
LWM38_18255	COG0561	phosphatase activity
LWM38_18270	COG2160	L-arabinose isomerase activity
LWM38_18280	COG1069	ribulokinase activity
LWM38_18285	COG1879	ABC-type sugar transport system periplasmic component
LWM38_18290	COG1129	ABC transporter
LWM38_18295	COG1172	Belongs to the binding-protein-dependent transport system permease family
LWM38_18305	COG0800	Aldolase
LWM38_18310	COG1464	Belongs to the NlpA lipoprotein family
LWM38_18315	COG3655	Transcriptional regulator
LWM38_18360	COG2885	chlorophyll binding
LWM38_18360	COG3047	cAMP biosynthetic process
LWM38_18430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LWM38_18435	COG0513	Belongs to the DEAD box helicase family
LWM38_18440	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LWM38_18455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LWM38_18490	COG2195	Cleaves the N-terminal amino acid of tripeptides
LWM38_18500	COG0667	Aldo Keto reductase
LWM38_18505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LWM38_18510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LWM38_18515	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LWM38_18520	COG0513	Belongs to the DEAD box helicase family
LWM38_18530	COG2176	DNA-directed DNA polymerase activity
LWM38_18545	COG0513	Belongs to the DEAD box helicase family
LWM38_18550	COG4989	oxidoreductase activity
LWM38_18570	COG1538	Outer membrane efflux protein
LWM38_18575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LWM38_18590	COG0840	transmembrane signaling receptor activity
LWM38_18600	COG0668	transmembrane transport
LWM38_18610	COG4232	protein-disulfide reductase activity
LWM38_18615	COG3118	belongs to the thioredoxin family
LWM38_18630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LWM38_18635	COG0697	spore germination
LWM38_18650	COG2814	Major facilitator Superfamily
LWM38_18655	COG0583	DNA-binding transcription factor activity
LWM38_18665	COG0739	heme binding
LWM38_18690	COG3314	Sporulation integral membrane protein YlbJ
LWM38_18700	COG0366	Alpha amylase catalytic
LWM38_18705	COG3344	reverse transcriptase
LWM38_18710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LWM38_18715	COG0784	Response regulator, receiver
LWM38_18715	COG0835	chemotaxis
LWM38_18720	COG2096	Adenosyltransferase
LWM38_18725	COG0748	coenzyme F420 binding
LWM38_18730	COG3721	Heme iron utilization protein
LWM38_18735	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LWM38_18740	COG0811	peptide transport
LWM38_18745	COG0848	biopolymer transport protein
LWM38_18755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LWM38_18760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LWM38_18805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LWM38_18810	COG0633	Ferredoxin
LWM38_18810	COG3217	Mosc domain protein beta barrel domain protein
LWM38_18820	COG0418	dihydroorotase activity
LWM38_18830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LWM38_18845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LWM38_18845	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LWM38_18850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LWM38_18855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LWM38_18860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LWM38_18890	COG0730	response to heat
LWM38_18900	COG1414	Transcriptional regulator
LWM38_18905	COG1012	belongs to the aldehyde dehydrogenase family
LWM38_18935	COG4934	collagen metabolic process
LWM38_18950	COG5002	protein histidine kinase activity
LWM38_18950	COG5001	Diguanylate cyclase
LWM38_18950	COG3447	MASE1 domain protein
LWM38_18980	COG3833	ABC-type maltose transport systems, permease component
LWM38_18985	COG1175	transmembrane transport
LWM38_18995	COG3842	ATPase activity
LWM38_19005	COG0840	transmembrane signaling receptor activity
LWM38_19010	COG0714	Associated with various cellular activities
LWM38_19025	COG2304	oxidoreductase activity
LWM38_19030	COG2304	oxidoreductase activity
LWM38_19040	COG3706	GGDEF domain
LWM38_19045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LWM38_19050	COG0581	inorganic phosphate transmembrane transporter activity
LWM38_19055	COG0573	inorganic phosphate transmembrane transporter activity
LWM38_19065	COG0840	transmembrane signaling receptor activity
LWM38_19085	COG4771	TonB-dependent receptor
LWM38_19090	COG1770	oligopeptidase
LWM38_19100	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LWM38_19105	COG3240	lipase activity
LWM38_19110	COG0513	Belongs to the DEAD box helicase family
LWM38_19120	COG1376	ErfK ybiS ycfS ynhG family protein
LWM38_19120	COG1388	LysM domain
LWM38_19125	COG0813	purine-nucleoside phosphorylase activity
LWM38_19140	COG3706	GGDEF domain
LWM38_19160	COG4720	Psort location CytoplasmicMembrane, score
LWM38_19165	COG1122	ATPase activity
LWM38_19180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LWM38_19185	COG1640	4-alpha-glucanotransferase
LWM38_19190	COG0058	SHG alpha-glucan phosphorylase activity
LWM38_19195	COG2909	trisaccharide binding
LWM38_19210	COG1999	signal sequence binding
LWM38_19225	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LWM38_19265	COG3258	Cytochrome c
LWM38_19270	COG0583	DNA-binding transcription factor activity
LWM38_19295	COG1523	belongs to the glycosyl hydrolase 13 family
LWM38_19305	COG0366	Alpha amylase catalytic
LWM38_19350	COG0204	Acyl-transferase
LWM38_19355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LWM38_19360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LWM38_19365	COG4667	esterase of the alpha-beta hydrolase superfamily
LWM38_19370	COG0753	catalase activity
LWM38_19375	COG1929	Belongs to the glycerate kinase type-1 family
LWM38_19380	COG2610	gluconate transmembrane transporter activity
LWM38_19385	COG3622	Belongs to the hyi family
LWM38_19390	COG0235	Class ii aldolase
LWM38_19395	COG3395	kinase activity
LWM38_19400	COG2084	Dehydrogenase
LWM38_19405	COG1349	DNA-binding transcription factor activity
LWM38_19425	COG0561	phosphatase activity
LWM38_19430	COG1309	transcriptional regulator
LWM38_19445	COG0798	PFAM Bile acid sodium symporter
LWM38_19450	COG0583	DNA-binding transcription factor activity
LWM38_19460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LWM38_19465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LWM38_19470	COG1349	DNA-binding transcription factor activity
LWM38_19475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LWM38_19495	COG1794	racemase activity, acting on amino acids and derivatives
LWM38_19510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LWM38_19515	COG0583	DNA-binding transcription factor activity
LWM38_19520	COG2814	Major facilitator Superfamily
LWM38_19525	COG0110	maltose O-acetyltransferase activity
LWM38_19530	COG1609	Transcriptional regulator
LWM38_19535	COG2723	6-phospho-beta-galactosidase activity
LWM38_19565	COG3321	synthase
LWM38_19565	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_19565	COG0604	alcohol dehydrogenase
LWM38_19575	COG2814	Major facilitator Superfamily
LWM38_19590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LWM38_19595	COG0110	maltose O-acetyltransferase activity
LWM38_19600	COG0628	permease
LWM38_19625	COG1803	Methylglyoxal synthase
LWM38_19625	COG1597	lipid kinase activity
LWM38_19650	COG0527	aspartate kinase activity
LWM38_19655	COG0662	Cupin 2, conserved barrel domain protein
LWM38_19660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LWM38_19665	COG0456	acetyltransferase
LWM38_19680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LWM38_19685	COG1072	(Pantothenic acid kinase))
LWM38_19695	COG1063	alcohol dehydrogenase
LWM38_19700	COG2213	PTS system mannitol-specific
LWM38_19705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_19715	COG1846	Transcriptional regulator
LWM38_19720	COG4175	Glycine betaine
LWM38_19720	COG0517	IMP dehydrogenase activity
LWM38_19740	COG1012	belongs to the aldehyde dehydrogenase family
LWM38_19745	COG1309	transcriptional regulator
LWM38_19750	COG0745	RESPONSE REGULATOR receiver
LWM38_19755	COG2205	protein histidine kinase activity
LWM38_19775	COG0579	oxidoreductase
LWM38_19790	COG2204	response regulator
LWM38_19800	COG2017	converts alpha-aldose to the beta-anomer
LWM38_19805	COG3940	Belongs to the glycosyl hydrolase 43 family
LWM38_19810	COG2211	Major facilitator Superfamily
LWM38_19820	COG0800	Aldolase
LWM38_19825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LWM38_19830	COG4145	pantothenate transmembrane transporter activity
LWM38_19840	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LWM38_19870	COG1566	PFAM secretion protein HlyD family protein
LWM38_19875	COG1846	Transcriptional regulator
LWM38_19910	COG1132	(ABC) transporter
LWM38_19915	COG4399	Belongs to the UPF0754 family
LWM38_19925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LWM38_19955	COG0259	pyridoxamine-phosphate oxidase activity
LWM38_19995	COG1444	tRNA N-acetyltransferase activity
LWM38_20020	COG4608	Belongs to the ABC transporter superfamily
LWM38_20025	COG0444	Belongs to the ABC transporter superfamily
LWM38_20035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LWM38_20035	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LWM38_20075	COG3842	ATPase activity
LWM38_20090	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LWM38_20100	COG0625	glutathione transferase activity
LWM38_20105	COG0861	Integral membrane protein TerC family
LWM38_20110	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_20120	COG3217	Mosc domain protein beta barrel domain protein
LWM38_20120	COG0633	Ferredoxin
LWM38_20125	COG3394	polysaccharide catabolic process
LWM38_20130	COG0583	DNA-binding transcription factor activity
LWM38_20140	COG2814	Major facilitator Superfamily
LWM38_20145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LWM38_20150	COG3186	Phenylalanine-4-hydroxylase
LWM38_20165	COG0217	transcriptional regulatory protein
LWM38_20175	COG2084	Dehydrogenase
LWM38_20195	COG4591	ABC-type transport system involved in lipoprotein release permease component
LWM38_20210	COG3275	phosphorelay sensor kinase activity
LWM38_20215	COG3279	Response regulator of the LytR AlgR family
LWM38_20220	COG0612	Peptidase, M16
LWM38_20230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWM38_20235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LWM38_20245	COG1902	pentaerythritol trinitrate reductase activity
LWM38_20250	COG2814	Major facilitator Superfamily
LWM38_20255	COG1028	Short-chain dehydrogenase reductase Sdr
LWM38_20280	COG0724	RNA recognition motif
LWM38_20305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LWM38_20330	COG0415	Belongs to the DNA photolyase family
LWM38_20340	COG3806	Anti-sigma factor
LWM38_20345	COG1595	DNA-templated transcription, initiation
LWM38_20355	COG1942	4-Oxalocrotonate Tautomerase
LWM38_20365	COG0786	glutamate:sodium symporter activity
LWM38_20390	COG2213	PTS system mannitol-specific
LWM38_20390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LWM38_20395	COG0246	Mannitol dehydrogenase
LWM38_20400	COG3722	fumarate hydratase activity
LWM38_20405	COG0363	glucosamine-6-phosphate deaminase activity
LWM38_20425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LWM38_20430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LWM38_20440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LWM38_20445	COG3366	ferrous iron transmembrane transporter activity
LWM38_20450	COG0700	Nucleoside recognition
LWM38_20455	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LWM38_20485	COG0596	Alpha beta hydrolase
LWM38_20500	COG3123	guanosine phosphorylase activity
LWM38_20505	COG1741	Belongs to the pirin family
LWM38_20535	COG1054	Belongs to the UPF0176 family
LWM38_20550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LWM38_20555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LWM38_20555	COG2207	Transcriptional regulator
LWM38_20560	COG0534	Mate efflux family protein
LWM38_20570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LWM38_20575	COG0747	negative chemotaxis
LWM38_20595	COG1304	FMN binding
LWM38_20600	COG1620	l-lactate permease
LWM38_20605	COG0583	DNA-binding transcription factor activity
LWM38_20610	COG1505	serine-type exopeptidase activity
LWM38_20620	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LWM38_20625	COG4172	Belongs to the ABC transporter superfamily
LWM38_20635	COG1067	ATP-dependent peptidase activity
LWM38_20665	COG1846	Transcriptional regulator
LWM38_20670	COG2259	Doxx family
LWM38_20680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LWM38_20685	COG3960	tartronate-semialdehyde synthase activity
LWM38_20690	COG3622	Belongs to the hyi family
LWM38_20695	COG2084	Dehydrogenase
LWM38_20710	COG0402	S-adenosylhomocysteine deaminase activity
LWM38_20735	COG2252	PERMEase
LWM38_20755	COG4266	Belongs to the allantoicase family
LWM38_20760	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LWM38_20775	COG0789	Transcriptional regulator
LWM38_20780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LWM38_20790	COG0402	S-adenosylhomocysteine deaminase activity
LWM38_20800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LWM38_20820	COG1418	mRNA catabolic process
LWM38_20825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LWM38_20830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LWM38_20865	COG1263	PTS System
LWM38_20865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity