locus-tag	class	description
AL543_00005	COG0641	radical SAM
AL543_00020	COG2814	Major facilitator Superfamily
AL543_00025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL543_00035	COG3335	DDE superfamily endonuclease
AL543_00075	COG3157	Type VI secretion system effector, Hcp
AL543_00085	COG1349	DNA-binding transcription factor activity
AL543_00090	COG2084	Dehydrogenase
AL543_00095	COG3395	kinase activity
AL543_00100	COG0235	Class ii aldolase
AL543_00105	COG3622	Belongs to the hyi family
AL543_00110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL543_00115	COG2610	gluconate transmembrane transporter activity
AL543_00220	COG0270	DNA (cytosine-5-)-methyltransferase activity
AL543_00265	COG4626	Terminase
AL543_00265	COG1802	Transcriptional regulator
AL543_00310	COG1063	alcohol dehydrogenase
AL543_00320	COG2873	o-acetylhomoserine
AL543_00330	COG0346	lactoylglutathione lyase activity
AL543_00345	COG2203	Gaf domain
AL543_00345	COG3706	GGDEF domain
AL543_00345	COG5001	Diguanylate cyclase
AL543_00345	COG4251	negative regulation of phosphorylation
AL543_00360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL543_00365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL543_00370	COG0363	glucosamine-6-phosphate deaminase activity
AL543_00375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL543_00395	COG1929	Belongs to the glycerate kinase type-1 family
AL543_00400	COG2610	gluconate transmembrane transporter activity
AL543_00405	COG3835	regulator
AL543_00410	COG1858	cytochrome C peroxidase
AL543_00420	COG0748	coenzyme F420 binding
AL543_00425	COG3721	Heme iron utilization protein
AL543_00435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL543_00440	COG0811	peptide transport
AL543_00445	COG0848	biopolymer transport protein
AL543_00450	COG4558	Periplasmic binding protein
AL543_00455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL543_00460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL543_00505	COG3217	Mosc domain protein beta barrel domain protein
AL543_00505	COG0633	Ferredoxin
AL543_00505	COG0633	Ferredoxin
AL543_00505	COG3217	Mosc domain protein beta barrel domain protein
AL543_00510	COG0418	dihydroorotase activity
AL543_00520	COG3335	DDE superfamily endonuclease
AL543_00530	COG3152	Membrane
AL543_00540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL543_00545	COG2354	Protein conserved in bacteria
AL543_00550	COG0488	(ABC) transporter
AL543_00560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL543_00565	COG1278	Cold shock
AL543_00595	COG1349	DNA-binding transcription factor activity
AL543_00605	COG0737	Belongs to the 5'-nucleotidase family
AL543_00620	COG3833	ABC-type maltose transport systems, permease component
AL543_00625	COG1175	transmembrane transport
AL543_00635	COG3842	ATPase activity
AL543_00640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_00655	COG0393	Putative heavy-metal-binding
AL543_00660	COG2197	response regulator
AL543_00680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL543_00685	COG0784	Response regulator, receiver
AL543_00685	COG0835	chemotaxis
AL543_00690	COG1846	Transcriptional regulator
AL543_00695	COG3706	GGDEF domain
AL543_00730	COG0583	DNA-binding transcription factor activity
AL543_00735	COG5001	Diguanylate cyclase
AL543_00745	COG1741	Belongs to the pirin family
AL543_00750	COG3123	guanosine phosphorylase activity
AL543_00760	COG2211	Major facilitator Superfamily
AL543_00775	COG1067	ATP-dependent peptidase activity
AL543_00785	COG4172	Belongs to the ABC transporter superfamily
AL543_00790	COG0583	DNA-binding transcription factor activity
AL543_00795	COG1620	l-lactate permease
AL543_00800	COG1304	FMN binding
AL543_00810	COG3385	transposase activity
AL543_00815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL543_00830	COG2172	sigma factor antagonist activity
AL543_00845	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL543_00850	COG0840	transmembrane signaling receptor activity
AL543_00855	COG0534	Mate efflux family protein
AL543_00860	COG1943	Transposase
AL543_00865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL543_00870	COG1126	abc transporter atp-binding protein
AL543_00880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_00885	COG4215	(ABC) transporter
AL543_00890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL543_00900	COG0739	heme binding
AL543_00905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_00905	COG2213	PTS system mannitol-specific
AL543_00910	COG0246	Mannitol dehydrogenase
AL543_00915	COG3722	fumarate hydratase activity
AL543_00920	COG0673	inositol 2-dehydrogenase activity
AL543_00950	COG0697	spore germination
AL543_00965	COG0583	DNA-binding transcription factor activity
AL543_00970	COG0655	NAD(P)H dehydrogenase (quinone) activity
AL543_00985	COG0697	spore germination
AL543_00990	COG2910	NAD(P)H-binding
AL543_01005	COG3335	DDE superfamily endonuclease
AL543_01010	COG4221	oxidoreductase activity
AL543_01025	COG1901	pseudouridine methyltransferase
AL543_01035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL543_01040	COG0531	amino acid
AL543_01045	COG1982	Orn Lys Arg decarboxylase major
AL543_01055	COG2197	response regulator
AL543_01095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL543_01120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL543_01130	COG0259	pyridoxamine-phosphate oxidase activity
AL543_01160	COG3537	Alpha-1,2-mannosidase
AL543_01170	COG3706	GGDEF domain
AL543_01170	COG0745	RESPONSE REGULATOR receiver
AL543_01190	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AL543_01195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL543_01200	COG0840	transmembrane signaling receptor activity
AL543_01205	COG0835	chemotaxis
AL543_01210	COG0835	chemotaxis
AL543_01215	COG0643	Histidine kinase
AL543_01215	COG2198	Histidine kinase
AL543_01230	COG0747	negative chemotaxis
AL543_01235	COG0601	transmembrane transport
AL543_01240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_01250	COG2194	sulfuric ester hydrolase activity
AL543_01255	COG1943	Transposase
AL543_01260	COG0642	Histidine kinase
AL543_01265	COG0745	RESPONSE REGULATOR receiver
AL543_01275	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_01295	COG1444	tRNA N-acetyltransferase activity
AL543_01300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL543_01340	COG0217	transcriptional regulatory protein
AL543_01345	COG2084	Dehydrogenase
AL543_01360	COG2909	trisaccharide binding
AL543_01365	COG0058	SHG alpha-glucan phosphorylase activity
AL543_01370	COG1640	4-alpha-glucanotransferase
AL543_01375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL543_01385	COG3501	Rhs element vgr protein
AL543_01420	COG0471	metal ion transport
AL543_01425	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL543_01455	COG0671	phosphoesterase, PA-phosphatase related
AL543_01465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL543_01470	COG2847	Copper chaperone PCu(A)C
AL543_01475	COG1999	signal sequence binding
AL543_01490	COG0786	glutamate:sodium symporter activity
AL543_01505	COG3655	Transcriptional regulator
AL543_01520	COG1566	PFAM secretion protein HlyD family protein
AL543_01530	COG3706	GGDEF domain
AL543_01545	COG0813	purine-nucleoside phosphorylase activity
AL543_01555	COG3272	Protein of unknown function (DUF1722)
AL543_01560	COG0789	Transcriptional regulator
AL543_01565	COG0415	Belongs to the DNA photolyase family
AL543_01570	COG1376	ErfK ybiS ycfS ynhG family protein
AL543_01570	COG1388	LysM domain
AL543_01580	COG0513	Belongs to the DEAD box helicase family
AL543_01590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL543_01595	COG0573	inorganic phosphate transmembrane transporter activity
AL543_01600	COG0581	inorganic phosphate transmembrane transporter activity
AL543_01605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL543_01625	COG0659	secondary active sulfate transmembrane transporter activity
AL543_01635	COG0739	heme binding
AL543_01645	COG0583	DNA-binding transcription factor activity
AL543_01650	COG2814	Major facilitator Superfamily
AL543_01660	COG3335	DDE superfamily endonuclease
AL543_01675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL543_01690	COG0678	peroxiredoxin activity
AL543_01690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_01695	COG0697	spore germination
AL543_01700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL543_01705	COG1764	response to oxidative stress
AL543_01710	COG1846	Transcriptional regulator
AL543_01730	COG2207	Transcriptional regulator
AL543_01735	COG1280	lysine exporter protein (LysE YggA)
AL543_01745	COG1132	(ABC) transporter
AL543_01755	COG1902	pentaerythritol trinitrate reductase activity
AL543_01765	COG0583	DNA-binding transcription factor activity
AL543_01775	COG0800	Aldolase
AL543_01780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_01785	COG1904	glucuronate isomerase
AL543_01790	COG0246	Mannitol dehydrogenase
AL543_01800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL543_01810	COG2186	Transcriptional regulator
AL543_01820	COG0513	Belongs to the DEAD box helicase family
AL543_01840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_01855	COG0840	transmembrane signaling receptor activity
AL543_01865	COG1943	Transposase
AL543_01870	COG0840	transmembrane signaling receptor activity
AL543_01880	COG1914	H( )-stimulated, divalent metal cation uptake system
AL543_01890	COG4580	involved in the transport of maltose and maltodextrins
AL543_01905	COG0363	glucosamine-6-phosphate deaminase activity
AL543_01930	COG2259	Doxx family
AL543_01935	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL543_01940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL543_01950	COG0471	metal ion transport
AL543_01960	COG4565	transcriptional regulatory protein
AL543_01965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL543_01970	COG3366	ferrous iron transmembrane transporter activity
AL543_01975	COG0700	Nucleoside recognition
AL543_01980	COG1301	dicarboxylic acid transport
AL543_01995	COG1342	Belongs to the UPF0251 family
AL543_02025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL543_02030	COG0673	inositol 2-dehydrogenase activity
AL543_02040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL543_02045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL543_02055	COG1943	Transposase
AL543_02060	COG0564	pseudouridine synthase activity
AL543_02150	COG3501	Rhs element vgr protein
AL543_02160	COG3335	DDE superfamily endonuclease
AL543_02180	COG1869	D-ribose catabolic process
AL543_02185	COG1129	ABC transporter
AL543_02190	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL543_02195	COG1879	ABC-type sugar transport system periplasmic component
AL543_02200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_02205	COG1609	Transcriptional regulator
AL543_02215	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL543_02225	COG0584	glycerophosphoryl diester phosphodiesterase
AL543_02230	COG2271	Major facilitator Superfamily
AL543_02270	COG0579	oxidoreductase
AL543_02280	COG0242	peptide deformylase activity
AL543_02295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_02300	COG1609	Transcriptional regulator
AL543_02305	COG1017	nitric oxide dioxygenase activity
AL543_02305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL543_02315	COG0814	amino acid
AL543_02320	COG3033	Beta-eliminating lyase
AL543_02330	COG3530	Putative quorum-sensing-regulated virulence factor
AL543_02340	COG5001	Diguanylate cyclase
AL543_02340	COG5002	protein histidine kinase activity
AL543_02345	COG1278	Cold shock
AL543_02380	COG2304	oxidoreductase activity
AL543_02400	COG0714	Associated with various cellular activities
AL543_02420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL543_02425	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_02435	COG3604	Transcriptional regulator
AL543_02440	COG1017	nitric oxide dioxygenase activity
AL543_02440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL543_02445	COG1278	Cold shock
AL543_02450	COG3036	rescue of stalled ribosome
AL543_02475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL543_02475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL543_02480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL543_02490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL543_02505	COG0516	GMP reductase activity
AL543_02510	COG4974	Belongs to the 'phage' integrase family
AL543_02605	COG4695	Portal protein
AL543_02740	COG0513	Belongs to the DEAD box helicase family
AL543_02745	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL543_02750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL543_02755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL543_02760	COG0840	transmembrane signaling receptor activity
AL543_02765	COG3437	response regulator, receiver
AL543_02765	COG0784	Response regulator, receiver
AL543_02770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_02770	COG4191	Histidine kinase
AL543_02780	COG1757	Na H antiporter
AL543_02785	COG2814	Major facilitator Superfamily
AL543_02795	COG3706	GGDEF domain
AL543_02800	COG3240	lipase activity
AL543_02810	COG0840	transmembrane signaling receptor activity
AL543_02815	COG4412	M6 family metalloprotease domain protein
AL543_02815	COG3291	Pkd domain containing protein
AL543_02835	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL543_02840	COG4605	iron ion homeostasis
AL543_02845	COG4604	ABC transporter, ATP-binding protein
AL543_02865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL543_02880	COG1263	PTS System
AL543_02880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_02890	COG2149	membrane
AL543_02905	COG3623	hexulose-6-phosphate isomerase
AL543_02910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL543_02915	COG0561	phosphatase activity
AL543_02945	COG3335	DDE superfamily endonuclease
AL543_02955	COG3335	DDE superfamily endonuclease
AL543_02960	COG4154	Belongs to the RbsD FucU family
AL543_02965	COG0235	Class ii aldolase
AL543_02980	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL543_02995	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_03025	COG3397	chitin binding
AL543_03030	COG3046	protein related to deoxyribodipyrimidine photolyase
AL543_03040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL543_03050	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL543_03055	COG0513	Belongs to the DEAD box helicase family
AL543_03065	COG1368	sulfuric ester hydrolase activity
AL543_03070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_03105	COG0484	heat shock protein binding
AL543_03115	COG1716	ATPase activity
AL543_03115	COG5001	Diguanylate cyclase
AL543_03120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL543_03130	COG4181	ATPase activity
AL543_03135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL543_03150	COG1984	allophanate hydrolase subunit 2
AL543_03155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL543_03160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL543_03165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL543_03175	COG0814	amino acid
AL543_03185	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL543_03190	COG0513	Belongs to the DEAD box helicase family
AL543_03205	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL543_03210	COG0494	nUDIX hydrolase
AL543_03220	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL543_03230	COG1126	abc transporter atp-binding protein
AL543_03235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_03240	COG4215	(ABC) transporter
AL543_03245	COG4160	amino acid transport
AL543_03250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL543_03255	COG0583	DNA-binding transcription factor activity
AL543_03260	COG3335	DDE superfamily endonuclease
AL543_03275	COG0243	molybdopterin cofactor binding
AL543_03300	COG0477	Major facilitator Superfamily
AL543_03305	COG3118	belongs to the thioredoxin family
AL543_03310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL543_03320	COG1215	transferase activity, transferring glycosyl groups
AL543_03330	COG0247	lactate metabolic process
AL543_03335	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AL543_03340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL543_03350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL543_03355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL543_03380	COG3335	DDE superfamily endonuclease
AL543_03385	COG2827	Endonuclease containing a URI domain
AL543_03395	COG1879	ABC-type sugar transport system periplasmic component
AL543_03400	COG0784	Response regulator, receiver
AL543_03400	COG5002	protein histidine kinase activity
AL543_03420	COG1492	cobalamin metabolic process
AL543_03425	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL543_03430	COG4149	molybdate abc transporter
AL543_03435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL543_03455	COG1289	transmembrane transporter activity
AL543_03460	COG0210	DNA helicase
AL543_03485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL543_03490	COG3335	DDE superfamily endonuclease
AL543_03500	COG1335	isochorismatase
AL543_03505	COG1803	Methylglyoxal synthase
AL543_03510	COG1879	ABC-type sugar transport system periplasmic component
AL543_03515	COG0784	Response regulator, receiver
AL543_03515	COG2198	Histidine kinase
AL543_03515	COG2205	protein histidine kinase activity
AL543_03520	COG0469	pyruvate kinase activity
AL543_03525	COG2271	Major facilitator Superfamily
AL543_03535	COG1840	ABC-type Fe3 transport system, periplasmic component
AL543_03540	COG4191	Histidine kinase
AL543_03565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL543_03570	COG3706	GGDEF domain
AL543_03585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_03590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_03600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL543_03605	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL543_03625	COG0183	Belongs to the thiolase family
AL543_03635	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL543_03645	COG0583	DNA-binding transcription factor activity
AL543_03665	COG4964	Belongs to the GSP D family
AL543_03720	COG3842	ATPase activity
AL543_03730	COG1840	ABC-type Fe3 transport system, periplasmic component
AL543_03735	COG2271	Major facilitator Superfamily
AL543_03740	COG3851	Histidine kinase
AL543_03745	COG2197	response regulator
AL543_03750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL543_03760	COG3005	denitrification pathway
AL543_03770	COG0243	molybdopterin cofactor binding
AL543_03780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL543_03780	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL543_03785	COG3850	Histidine kinase
AL543_03790	COG2197	response regulator
AL543_03795	COG1760	l-serine dehydratase
AL543_03800	COG3069	C4-dicarboxylate transmembrane transporter activity
AL543_03805	COG0840	transmembrane signaling receptor activity
AL543_03810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL543_03815	COG0545	Peptidyl-prolyl cis-trans isomerase
AL543_03825	COG0840	transmembrane signaling receptor activity
AL543_03830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL543_03885	COG1566	PFAM secretion protein HlyD family protein
AL543_03905	COG0640	Transcriptional regulator
AL543_03930	COG1943	Transposase
AL543_03945	COG0583	DNA-binding transcription factor activity
AL543_03980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL543_04010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL543_04015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL543_04025	COG2390	Transcriptional regulator
AL543_04035	COG2897	thiosulfate sulfurtransferase activity
AL543_04045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL543_04055	COG0302	gtp cyclohydrolase
AL543_04060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_04060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_04065	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL543_04070	COG1970	mechanosensitive ion channel activity
AL543_04075	COG1454	alcohol dehydrogenase
AL543_04080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL543_04095	COG1011	Hydrolase
AL543_04100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL543_04105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL543_04115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL543_04120	COG1840	ABC-type Fe3 transport system, periplasmic component
AL543_04125	COG3842	ATPase activity
AL543_04170	COG4166	transmembrane transport
AL543_04175	COG4174	ABC transporter (Permease)
AL543_04180	COG4239	(ABC) transporter, permease
AL543_04185	COG4172	Belongs to the ABC transporter superfamily
AL543_04195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL543_04210	COG0625	glutathione transferase activity
AL543_04230	COG2050	protein possibly involved in aromatic compounds catabolism
AL543_04250	COG0583	DNA-binding transcription factor activity
AL543_04255	COG1042	CoA-binding domain protein
AL543_04255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_04255	COG0045	succinate-CoA ligase (ADP-forming) activity
AL543_04265	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL543_04275	COG0023	Translation Initiation Factor
AL543_04285	COG1132	(ABC) transporter
AL543_04290	COG1132	(ABC) transporter
AL543_04295	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL543_04305	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AL543_04320	COG3433	isochorismatase activity
AL543_04320	COG2226	methyltransferase
AL543_04320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL543_04325	COG2814	Major facilitator Superfamily
AL543_04330	COG4771	TonB-dependent receptor
AL543_04420	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL543_04425	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL543_04440	COG0745	RESPONSE REGULATOR receiver
AL543_04440	COG3706	GGDEF domain
AL543_04460	COG3706	GGDEF domain
AL543_04495	COG2824	Alkylphosphonate utilization operon protein PhnA
AL543_04510	COG0737	Belongs to the 5'-nucleotidase family
AL543_04515	COG3593	DNA synthesis involved in DNA repair
AL543_04525	COG0583	DNA-binding transcription factor activity
AL543_04530	COG2116	formate transmembrane transporter activity
AL543_04540	COG3038	cytochrome b561
AL543_04550	COG5001	Diguanylate cyclase
AL543_04550	COG3300	MHYT domain
AL543_04575	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AL543_04580	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AL543_04585	COG1737	Transcriptional regulator
AL543_04590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL543_04595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL543_04600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL543_04605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL543_04615	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AL543_04620	COG1940	carbohydrate kinase activity
AL543_04625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL543_04630	COG3335	DDE superfamily endonuclease
AL543_04640	COG3335	DDE superfamily endonuclease
AL543_04655	COG0523	cobalamin synthesis protein
AL543_04660	COG0038	chloride channel
AL543_04675	COG0156	8-amino-7-oxononanoate synthase activity
AL543_04680	COG0784	Response regulator, receiver
AL543_04680	COG2205	protein histidine kinase activity
AL543_04685	COG0419	ATPase involved in DNA repair
AL543_04690	COG0420	3'-5' exonuclease activity
AL543_04695	COG1609	Transcriptional regulator
AL543_04700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_04700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_04705	COG1105	Belongs to the carbohydrate kinase PfkB family
AL543_04710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_04710	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL543_04710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_04715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL543_04720	COG4067	protein conserved in archaea
AL543_04720	COG0189	ligase activity
AL543_04730	COG0602	queuosine metabolic process
AL543_04735	COG1328	CTP reductase activity
AL543_04745	COG1917	Cupin 2, conserved barrel domain protein
AL543_04745	COG4977	sequence-specific DNA binding
AL543_04755	COG3335	DDE superfamily endonuclease
AL543_04815	COG0346	lactoylglutathione lyase activity
AL543_04825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_04845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_04870	COG3335	DDE superfamily endonuclease
AL543_05155	COG3335	DDE superfamily endonuclease
AL543_05200	COG4628	conserved protein (DUF2132)
AL543_05220	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_05270	COG0110	maltose O-acetyltransferase activity
AL543_05280	COG3093	addiction module antidote protein HigA
AL543_05285	COG3549	Plasmid maintenance system killer
AL543_05290	COG0346	lactoylglutathione lyase activity
AL543_05360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_05380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_05490	COG4115	mRNA cleavage
AL543_05495	COG2161	toxin-antitoxin pair type II binding
AL543_05545	COG0653	protein targeting
AL543_05550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_05550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_05565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_05575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_05620	COG0653	protein targeting
AL543_05630	COG1943	Transposase
AL543_05635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL543_05640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL543_05650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL543_05655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL543_05665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL543_05670	COG0509	glycine decarboxylation via glycine cleavage system
AL543_05675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL543_05675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL543_05680	COG2755	lipolytic protein G-D-S-L family
AL543_05685	COG3338	carbonate dehydratase activity
AL543_05700	COG1686	Belongs to the peptidase S11 family
AL543_05705	COG1414	Transcriptional regulator
AL543_05720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_05725	COG0601	transmembrane transport
AL543_05740	COG0641	radical SAM
AL543_05745	COG3119	arylsulfatase activity
AL543_05750	COG3119	arylsulfatase activity
AL543_05775	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_05780	COG1085	galactose-1-phosphate uridylyltransferase
AL543_05785	COG0800	Aldolase
AL543_05790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_05810	COG1166	arginine decarboxylase activity
AL543_05835	COG2239	Acts as a magnesium transporter
AL543_05840	COG0527	aspartate kinase activity
AL543_05845	COG0662	Cupin 2, conserved barrel domain protein
AL543_05850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL543_05855	COG0456	acetyltransferase
AL543_05870	COG0534	Mate efflux family protein
AL543_05880	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL543_05885	COG3186	Phenylalanine-4-hydroxylase
AL543_05890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL543_05905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL543_05915	COG2171	N-acyltransferase activity
AL543_05920	COG1253	flavin adenine dinucleotide binding
AL543_05925	COG1765	OsmC-like protein
AL543_05935	COG5001	Diguanylate cyclase
AL543_05955	COG0531	amino acid
AL543_05960	COG3706	GGDEF domain
AL543_05970	COG3279	Response regulator of the LytR AlgR family
AL543_05975	COG3275	phosphorelay sensor kinase activity
AL543_05990	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL543_05995	COG1136	(ABC) transporter
AL543_06005	COG4989	oxidoreductase activity
AL543_06010	COG0366	Alpha amylase catalytic
AL543_06015	COG3335	DDE superfamily endonuclease
AL543_06040	COG3227	Zinc metalloprotease (Elastase)
AL543_06050	COG3047	cAMP biosynthetic process
AL543_06060	COG1686	Belongs to the peptidase S11 family
AL543_06065	COG0587	DNA-directed DNA polymerase activity
AL543_06070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL543_06075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_06080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_06085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL543_06090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_06095	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL543_06105	COG0750	zinc metalloprotease
AL543_06110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL543_06115	COG0575	Belongs to the CDS family
AL543_06120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL543_06125	COG0233	cytoplasmic translational termination
AL543_06130	COG0528	UMP kinase activity
AL543_06135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL543_06140	COG0052	Belongs to the universal ribosomal protein uS2 family
AL543_06145	COG0024	Methionine aminopeptidase
AL543_06150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL543_06160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL543_06165	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL543_06170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL543_06175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL543_06190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_06190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL543_06195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL543_06200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL543_06205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL543_06220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL543_06225	COG2252	PERMEase
AL543_06230	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_06235	COG4067	protein conserved in archaea
AL543_06235	COG0189	ligase activity
AL543_06240	COG0189	ligase activity
AL543_06250	COG0733	neurotransmitter:sodium symporter activity
AL543_06255	COG3706	GGDEF domain
AL543_06255	COG4251	negative regulation of phosphorylation
AL543_06255	COG5001	Diguanylate cyclase
AL543_06255	COG2203	Gaf domain
AL543_06265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL543_06275	COG1477	protein flavinylation
AL543_06285	COG2871	sodium ion transport
AL543_06290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_06295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_06300	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_06305	COG1805	sodium ion transport
AL543_06310	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL543_06315	COG0271	Belongs to the BolA IbaG family
AL543_06320	COG2813	Specifically methylates the guanine in position
AL543_06330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL543_06335	COG2211	Major facilitator Superfamily
AL543_06345	COG1595	DNA-templated transcription, initiation
AL543_06360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL543_06365	COG0693	protein deglycase activity
AL543_06370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL543_06375	COG2166	iron-sulfur cluster assembly
AL543_06380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL543_06385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL543_06395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL543_06395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL543_06410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL543_06415	COG1074	ATP-dependent DNA helicase activity
AL543_06420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL543_06435	COG3141	response to X-ray
AL543_06440	COG2171	N-acyltransferase activity
AL543_06445	COG1943	Transposase
AL543_06460	COG0569	domain protein
AL543_06460	COG0189	ligase activity
AL543_06475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_06480	COG1609	Transcriptional regulator
AL543_06485	COG3385	transposase activity
AL543_06490	COG3250	beta-galactosidase activity
AL543_06505	COG1022	Amp-dependent synthetase and ligase
AL543_06515	COG0583	DNA-binding transcription factor activity
AL543_06520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL543_06525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL543_06545	COG0560	Phosphoserine phosphatase
AL543_06555	COG0813	purine-nucleoside phosphorylase activity
AL543_06560	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL543_06565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL543_06570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL543_06580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL543_06585	COG0084	hydrolase, TatD family'
AL543_06595	COG1115	amino acid carrier protein
AL543_06610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL543_06615	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL543_06620	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL543_06625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL543_06630	COG0083	homoserine kinase activity
AL543_06645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL543_06655	COG0745	RESPONSE REGULATOR receiver
AL543_06660	COG5002	protein histidine kinase activity
AL543_06660	COG2198	Histidine kinase
AL543_06660	COG0784	Response regulator, receiver
AL543_06665	COG2203	Gaf domain
AL543_06665	COG3706	GGDEF domain
AL543_06665	COG4251	negative regulation of phosphorylation
AL543_06665	COG5001	Diguanylate cyclase
AL543_06670	COG1242	4 iron, 4 sulfur cluster binding
AL543_06675	COG0070	glutamate synthase
AL543_06675	COG0067	glutamate synthase
AL543_06675	COG0069	glutamate synthase activity
AL543_06685	COG0069	glutamate synthase activity
AL543_06685	COG0070	glutamate synthase
AL543_06685	COG0067	glutamate synthase
AL543_06690	COG0493	'glutamate synthase
AL543_06700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL543_06710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL543_06715	COG2860	membrane
AL543_06720	COG0583	DNA-binding transcription factor activity
AL543_06725	COG0730	response to heat
AL543_06730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL543_06735	COG0505	Belongs to the CarA family
AL543_06740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL543_06750	COG0494	nUDIX hydrolase
AL543_06755	COG0653	protein targeting
AL543_06775	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL543_06780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL543_06785	COG0849	cell division
AL543_06790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL543_06795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL543_06800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL543_06805	COG0772	Belongs to the SEDS family
AL543_06810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL543_06815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL543_06820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL543_06825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL543_06830	COG0768	penicillin binding
AL543_06835	COG3116	cell division
AL543_06840	COG0275	rRNA processing
AL543_06850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_06855	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL543_06860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL543_06865	COG2186	Transcriptional regulator
AL543_06870	COG0737	Belongs to the 5'-nucleotidase family
AL543_06875	COG1227	inorganic diphosphatase activity
AL543_06880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL543_06885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL543_06890	COG4974	Belongs to the 'phage' integrase family
AL543_06895	COG0716	FMN binding
AL543_06915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL543_06920	COG1459	type II secretion system
AL543_06930	COG0237	dephospho-CoA kinase activity
AL543_06935	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL543_06940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL543_06945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL543_06950	COG0187	DNA topoisomerase II activity
AL543_06955	COG3150	esterase
AL543_06965	COG3151	Protein conserved in bacteria
AL543_06970	COG0494	nUDIX hydrolase
AL543_06975	COG1538	Outer membrane efflux protein
AL543_06985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL543_06995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL543_07000	COG3025	triphosphatase activity
AL543_07005	COG1392	Phosphate transport regulator
AL543_07010	COG0306	phosphate transporter
AL543_07015	COG4991	sh3 domain protein
AL543_07025	COG3409	Peptidoglycan-binding domain 1 protein
AL543_07025	COG3267	Type II secretory pathway component ExeA
AL543_07030	COG0617	tRNA 3'-terminal CCA addition
AL543_07040	COG0814	amino acid
AL543_07045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL543_07050	COG0148	phosphopyruvate hydratase activity
AL543_07055	COG0504	CTP synthase activity
AL543_07065	COG3956	TIGRFAM MazG family protein
AL543_07070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL543_07075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL543_07080	COG3437	response regulator, receiver
AL543_07080	COG2205	protein histidine kinase activity
AL543_07080	COG3850	Histidine kinase
AL543_07080	COG4999	Histidine kinase
AL543_07085	COG5001	Diguanylate cyclase
AL543_07100	COG0736	holo-[acyl-carrier-protein] synthase activity
AL543_07105	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL543_07110	COG1381	Involved in DNA repair and RecF pathway recombination
AL543_07115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL543_07120	COG0571	ribonuclease III activity
AL543_07125	COG0681	Belongs to the peptidase S26 family
AL543_07130	COG0481	GTPase activity
AL543_07135	COG3086	response to oxidative stress
AL543_07150	COG1595	DNA-templated transcription, initiation
AL543_07160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL543_07170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL543_07175	COG0354	folic acid binding
AL543_07185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL543_07190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL543_07195	COG3079	Belongs to the UPF0149 family
AL543_07200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL543_07210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL543_07215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL543_07220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL543_07225	COG0440	acetolactate synthase activity
AL543_07230	COG0028	Belongs to the TPP enzyme family
AL543_07235	COG1022	Amp-dependent synthetase and ligase
AL543_07240	COG0583	DNA-binding transcription factor activity
AL543_07250	COG0671	phosphoesterase, PA-phosphatase related
AL543_07260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL543_07265	COG0473	3-isopropylmalate dehydrogenase activity
AL543_07270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL543_07275	COG0066	3-isopropylmalate dehydratase activity
AL543_07335	COG3437	response regulator, receiver
AL543_07350	COG0795	lipopolysaccharide-transporting ATPase activity
AL543_07355	COG0795	lipopolysaccharide-transporting ATPase activity
AL543_07360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL543_07365	COG2927	DNA polymerase III (CHI subunit)
AL543_07370	COG0525	valine-tRNA ligase activity
AL543_07390	COG4269	membrane
AL543_07395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL543_07400	COG0564	pseudouridine synthase activity
AL543_07405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL543_07415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL543_07420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL543_07425	COG0540	Belongs to the ATCase OTCase family
AL543_07430	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL543_07435	COG0251	oxidation-reduction process
AL543_07440	COG0204	Acyl-transferase
AL543_07445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL543_07450	COG5007	Belongs to the BolA IbaG family
AL543_07460	COG2854	intermembrane phospholipid transfer
AL543_07465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL543_07470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL543_07475	COG1127	ABC transporter
AL543_07490	COG0517	IMP dehydrogenase activity
AL543_07490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL543_07505	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL543_07510	COG1137	ATPase activity
AL543_07520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL543_07525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_07535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_07540	COG2239	Acts as a magnesium transporter
AL543_07545	COG0312	modulator of DNA gyrase
AL543_07550	COG3028	Belongs to the UPF0307 family
AL543_07555	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL543_07560	COG1178	ABC-type Fe3 transport system permease component
AL543_07565	COG4143	(ABC) transporter
AL543_07570	COG0163	prenyltransferase activity
AL543_07575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL543_07585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL543_07590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL543_07600	COG2105	PFAM AIG2 family protein
AL543_07605	COG2911	Protein conserved in bacteria
AL543_07610	COG0729	surface antigen
AL543_07615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_07620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL543_07635	COG1136	(ABC) transporter
AL543_07655	COG0529	Catalyzes the synthesis of activated sulfate
AL543_07660	COG2895	sulfate adenylyltransferase (ATP) activity
AL543_07665	COG0175	sulfate reduction
AL543_07670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL543_07670	COG1648	precorrin-2 dehydrogenase activity
AL543_07675	COG0737	Belongs to the 5'-nucleotidase family
AL543_07685	COG0513	Belongs to the DEAD box helicase family
AL543_07690	COG2153	protein acetylation
AL543_07695	COG0697	spore germination
AL543_07700	COG3061	Opacity-associated protein A
AL543_07705	COG0545	Peptidyl-prolyl cis-trans isomerase
AL543_07715	COG0203	ribosomal protein L17
AL543_07720	COG0202	RNA polymerase activity
AL543_07725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL543_07730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL543_07735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL543_07745	COG0201	protein transport
AL543_07750	COG0200	Binds to the 23S rRNA
AL543_07755	COG1841	ribosomal large subunit assembly
AL543_07760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL543_07765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL543_07770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL543_07775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL543_07780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL543_07785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL543_07790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL543_07795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL543_07805	COG0255	Belongs to the universal ribosomal protein uL29 family
AL543_07810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL543_07815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL543_07820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL543_07825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL543_07830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL543_07835	COG0089	rRNA binding
AL543_07840	COG0088	Forms part of the polypeptide exit tunnel
AL543_07845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL543_07850	COG0051	transcription antitermination factor activity, RNA binding
AL543_07855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL543_07860	COG0557	exoribonuclease II activity
AL543_07865	COG3083	sulfuric ester hydrolase activity
AL543_07870	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL543_07875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL543_07885	COG1047	Peptidyl-prolyl cis-trans
AL543_07900	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL543_07905	COG0488	(ABC) transporter
AL543_07915	COG0429	hydrolase of the alpha beta-hydrolase fold
AL543_07925	COG3954	Phosphoribulokinase
AL543_07930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL543_07940	COG1012	belongs to the aldehyde dehydrogenase family
AL543_07950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL543_07960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL543_07975	COG0180	Tryptophanyl-tRNA synthetase
AL543_07980	COG0546	phosphoglycolate phosphatase activity
AL543_07985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL543_07990	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL543_08000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL543_08005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL543_08035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL543_08045	COG0678	peroxiredoxin activity
AL543_08045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_08050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_08060	COG0165	Argininosuccinate lyase
AL543_08065	COG0137	argininosuccinate synthase activity
AL543_08070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL543_08075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL543_08080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL543_08085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL543_08095	COG1045	serine acetyltransferase
AL543_08100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL543_08105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL543_08110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL543_08115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL543_08120	COG1053	succinate dehydrogenase
AL543_08125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL543_08130	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL543_08135	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL543_08140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL543_08145	COG1509	lysine 2,3-aminomutase activity
AL543_08165	COG0459	protein refolding
AL543_08170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL543_08195	COG0149	triose-phosphate isomerase activity
AL543_08205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL543_08210	COG1575	Belongs to the MenA family. Type 1 subfamily
AL543_08215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL543_08220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL543_08230	COG1609	Transcriptional regulator
AL543_08235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL543_08240	COG0254	rRNA binding
AL543_08245	COG0281	malic enzyme
AL543_08250	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL543_08255	COG0626	cystathionine gamma-synthase activity
AL543_08260	COG0527	aspartate kinase activity
AL543_08260	COG0460	homoserine dehydrogenase
AL543_08265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL543_08270	COG3074	FtsZ-dependent cytokinesis
AL543_08275	COG1494	fructose-1,6-bisphosphatase
AL543_08280	COG0205	6-phosphofructokinase activity
AL543_08285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL543_08295	COG0745	RESPONSE REGULATOR receiver
AL543_08300	COG2205	protein histidine kinase activity
AL543_08310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL543_08320	COG1027	Aspartate ammonia-lyase
AL543_08325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL543_08330	COG4232	protein-disulfide reductase activity
AL543_08340	COG3263	regulation of cellular component size
AL543_08350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL543_08355	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL543_08360	COG0194	GDP metabolic process
AL543_08365	COG1758	RNA polymerase activity
AL543_08370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL543_08375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL543_08380	COG2233	PERMEase
AL543_08390	COG0745	RESPONSE REGULATOR receiver
AL543_08395	COG1472	Belongs to the glycosyl hydrolase 3 family
AL543_08400	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL543_08405	COG1129	ABC transporter
AL543_08420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL543_08425	COG2183	response to ionizing radiation
AL543_08435	COG0596	Alpha beta hydrolase
AL543_08445	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL543_08445	COG0316	Belongs to the HesB IscA family
AL543_08450	COG0494	nUDIX hydrolase
AL543_08455	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL543_08465	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL543_08470	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL543_08475	COG3156	type II secretion system protein K
AL543_08480	COG4795	General secretion pathway protein
AL543_08485	COG2165	general secretion pathway protein
AL543_08490	COG2165	general secretion pathway protein
AL543_08495	COG2165	general secretion pathway protein
AL543_08500	COG1459	type II secretion system
AL543_08505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL543_08515	COG3031	protein transport across the cell outer membrane
AL543_08520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL543_08525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL543_08530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL543_08540	COG0456	acetyltransferase
AL543_08545	COG1490	D-aminoacyl-tRNA deacylase activity
AL543_08570	COG0174	glutamine synthetase
AL543_08580	COG3852	Histidine kinase
AL543_08590	COG5001	Diguanylate cyclase
AL543_08590	COG3300	MHYT domain
AL543_08595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL543_08605	COG3335	DDE superfamily endonuclease
AL543_08615	COG3335	DDE superfamily endonuclease
AL543_08680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL543_08685	COG1404	Belongs to the peptidase S8 family
AL543_08690	COG4206	TonB-dependent receptor
AL543_08695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL543_08730	COG2003	Belongs to the UPF0758 family
AL543_08785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_08790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL543_08795	COG2177	Part of the ABC transporter FtsEX involved in
AL543_08800	COG2884	Cell division ATP-binding protein ftsE
AL543_08805	COG0552	protein localization to endoplasmic reticulum
AL543_08810	COG0742	ribosomal rna small subunit methyltransferase
AL543_08845	COG0783	Belongs to the Dps family
AL543_08850	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL543_08855	COG1280	lysine exporter protein (LysE YggA)
AL543_08860	COG2267	carboxylic ester hydrolase activity
AL543_08865	COG0561	phosphatase activity
AL543_08880	COG2199	diguanylate cyclase activity
AL543_08880	COG3287	FIST C domain
AL543_08880	COG2200	EAL domain
AL543_08885	COG1011	Hydrolase
AL543_08890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL543_08900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL543_08905	COG0019	diaminopimelate decarboxylase activity
AL543_08915	COG1965	Belongs to the frataxin family
AL543_08920	COG3072	Adenylate cyclase
AL543_08930	COG0181	hydroxymethylbilane synthase activity
AL543_08935	COG1587	Uroporphyrinogen-III synthase
AL543_08940	COG2959	enzyme of heme biosynthesis
AL543_08945	COG3071	HemY protein
AL543_08950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL543_08960	COG3078	GTPase activator activity
AL543_08975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL543_08985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL543_08985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL543_08990	COG0456	acetyltransferase
AL543_09000	COG0084	hydrolase, TatD family'
AL543_09010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL543_09020	COG1580	Controls the rotational direction of flagella during chemotaxis
AL543_09030	COG3161	chorismate lyase activity
AL543_09035	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL543_09040	COG2937	Belongs to the GPAT DAPAT family
AL543_09045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL543_09055	COG0534	Mate efflux family protein
AL543_09060	COG0805	protein transport
AL543_09065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL543_09070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL543_09075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL543_09085	COG2226	methyltransferase
AL543_09090	COG1322	Protein conserved in bacteria
AL543_09100	COG0840	transmembrane signaling receptor activity
AL543_09160	COG3335	DDE superfamily endonuclease
AL543_09175	COG2081	HI0933 family
AL543_09185	COG1528	Iron-storage protein
AL543_09195	COG0589	response to stress
AL543_09200	COG0697	spore germination
AL543_09210	COG0742	ribosomal rna small subunit methyltransferase
AL543_09215	COG5001	Diguanylate cyclase
AL543_09215	COG5002	protein histidine kinase activity
AL543_09220	COG1522	sequence-specific DNA binding
AL543_09230	COG2814	Major facilitator Superfamily
AL543_09240	COG0006	proline dipeptidase activity
AL543_09240	COG0006	proline dipeptidase activity
AL543_09245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL543_09250	COG2022	thiamine diphosphate biosynthetic process
AL543_09255	COG2104	thiamine diphosphate biosynthetic process
AL543_09260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL543_09270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL543_09275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL543_09290	COG0582	viral genome integration into host DNA
AL543_09305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL543_09310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_09310	COG1263	PTS System
AL543_09320	COG3335	DDE superfamily endonuclease
AL543_09415	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AL543_09420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL543_09425	COG1739	Uncharacterized protein family UPF0029
AL543_09430	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL543_09430	COG1024	Enoyl-CoA hydratase
AL543_09435	COG0183	Belongs to the thiolase family
AL543_09440	COG0583	DNA-binding transcription factor activity
AL543_09445	COG2814	Major facilitator Superfamily
AL543_09455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL543_09460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL543_09465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL543_09470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL543_09475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL543_09480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL543_09490	COG0356	it plays a direct role in the translocation of protons across the membrane
AL543_09495	COG3312	ion transport
AL543_09500	COG1475	DNA binding
AL543_09505	COG1192	Involved in chromosome partitioning
AL543_09510	COG0357	Ribosomal RNA small subunit methyltransferase G
AL543_09515	COG0445	tRNA wobble uridine modification
AL543_09520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL543_09535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL543_09540	COG0706	membrane insertase activity
AL543_09545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL543_09550	COG0594	ribonuclease P activity
AL543_09555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL543_09560	COG1126	abc transporter atp-binding protein
AL543_09575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL543_09580	COG0592	DNA-directed DNA polymerase activity
AL543_09585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL543_09590	COG0187	DNA topoisomerase II activity
AL543_09605	COG0071	Belongs to the small heat shock protein (HSP20) family
AL543_09610	COG3977	Valine--pyruvate aminotransferase
AL543_09615	COG0751	glycine-tRNA ligase activity
AL543_09620	COG0752	glycyl-tRNA synthetase alpha subunit
AL543_09625	COG2119	membrane
AL543_09635	COG0425	Belongs to the sulfur carrier protein TusA family
AL543_09650	COG0604	alcohol dehydrogenase
AL543_09660	COG0129	dihydroxy-acid dehydratase activity
AL543_09665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL543_09680	COG0606	chelatase, subunit chli
AL543_09685	COG0204	Acyl-transferase
AL543_09690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL543_09695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL543_09705	COG3084	Protein conserved in bacteria
AL543_09715	COG4326	sporulation control protein
AL543_09720	COG1272	protein, Hemolysin III
AL543_09730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL543_09735	COG0569	domain protein
AL543_09740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL543_09740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL543_09750	COG0242	peptide deformylase activity
AL543_09755	COG1652	LysM domain
AL543_09760	COG0758	DNA mediated transformation
AL543_09765	COG2922	Belongs to the Smg family
AL543_09770	COG0551	DNA topoisomerase type I activity
AL543_09775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL543_09780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL543_09785	COG0009	L-threonylcarbamoyladenylate synthase
AL543_09795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL543_09805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL543_09850	COG0583	DNA-binding transcription factor activity
AL543_09855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL543_09860	COG2960	long-chain fatty acid transporting porin activity
AL543_09865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_09870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_09875	COG1309	transcriptional regulator
AL543_09925	COG0747	negative chemotaxis
AL543_09935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_10035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL543_10040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL543_10050	COG0210	DNA helicase
AL543_10060	COG1280	lysine exporter protein (LysE YggA)
AL543_10075	COG2962	Rard protein
AL543_10080	COG0514	ATP-dependent DNA helicase (RecQ)
AL543_10095	COG4774	siderophore transport
AL543_10100	COG1120	ATPase activity
AL543_10125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL543_10130	COG1263	PTS System
AL543_10130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_10140	COG1561	YicC-like family, N-terminal region
AL543_10145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL543_10150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL543_10155	COG3385	transposase activity
AL543_10160	COG1560	Kdo2-lipid A biosynthetic process
AL543_10165	COG1560	Kdo2-lipid A biosynthetic process
AL543_10170	COG1309	transcriptional regulator
AL543_10175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL543_10190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL543_10195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL543_10205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL543_10210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL543_10215	COG0859	PFAM glycosyl transferase family 9
AL543_10225	COG0463	Glycosyl transferase, family 2
AL543_10230	COG0859	PFAM glycosyl transferase family 9
AL543_10235	COG3642	lipopolysaccharide core region biosynthetic process
AL543_10260	COG1519	Transferase
AL543_10300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL543_10305	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AL543_10320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL543_10325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL543_10335	COG1216	Glycosyl transferase, family 2
AL543_10355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL543_10365	COG0668	transmembrane transport
AL543_10370	COG1573	uracil-dna glycosylase
AL543_10380	COG3068	Protein conserved in bacteria
AL543_10385	COG1253	flavin adenine dinucleotide binding
AL543_10390	COG0776	regulation of translation
AL543_10400	COG0151	Belongs to the GarS family
AL543_10405	COG0138	bifunctional purine biosynthesis protein purh
AL543_10410	COG0789	Transcriptional regulator
AL543_10415	COG3710	Transcriptional regulator
AL543_10420	COG0531	amino acid
AL543_10425	COG1982	Orn Lys Arg decarboxylase major
AL543_10430	COG0840	transmembrane signaling receptor activity
AL543_10445	COG0800	Aldolase
AL543_10450	COG2610	gluconate transmembrane transporter activity
AL543_10455	COG3265	gluconokinase activity
AL543_10460	COG0129	dihydroxy-acid dehydratase activity
AL543_10465	COG1609	Transcriptional regulator
AL543_10470	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL543_10475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL543_10480	COG2264	protein methyltransferase activity
AL543_10485	COG0439	Biotin carboxylase
AL543_10490	COG0511	ligase activity, forming carbon-carbon bonds
AL543_10495	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL543_10500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL543_10520	COG2814	Major facilitator Superfamily
AL543_10540	COG0248	Ppx GppA phosphatase
AL543_10545	COG0513	Belongs to the DEAD box helicase family
AL543_10550	COG3118	belongs to the thioredoxin family
AL543_10555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL543_10565	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL543_10620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL543_10635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL543_10645	COG1072	(Pantothenic acid kinase))
AL543_10670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL543_10675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL543_10680	COG0250	Participates in transcription elongation, termination and antitermination
AL543_10685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL543_10690	COG0081	regulation of translation
AL543_10695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL543_10700	COG0222	ribosome binding
AL543_10705	COG0085	RNA polymerase activity
AL543_10710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL543_10715	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL543_10720	COG2816	NAD+ diphosphatase activity
AL543_10725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL543_10740	COG4942	peptidase
AL543_10745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL543_10755	COG0471	metal ion transport
AL543_10760	COG0688	phosphatidylethanolamine metabolic process
AL543_10765	COG1162	GTPase activity
AL543_10770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL543_10815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL543_10820	COG0802	atpase or kinase
AL543_10825	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL543_10830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL543_10835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL543_10840	COG1923	regulation of RNA biosynthetic process
AL543_10845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL543_10850	COG0330	HflC and HflK could
AL543_10855	COG0330	HflC and HflK could
AL543_10860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL543_10865	COG2900	Belongs to the SlyX family
AL543_10875	COG0545	Peptidyl-prolyl cis-trans isomerase
AL543_10880	COG2964	Protein conserved in bacteria
AL543_10885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL543_10890	COG2923	Belongs to the DsrF TusC family
AL543_10900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL543_10905	COG0049	tRNA binding
AL543_10910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL543_10915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL543_10920	COG2906	2 iron, 2 sulfur cluster binding
AL543_10930	COG0360	Binds together with S18 to 16S ribosomal RNA
AL543_10935	COG2965	DNA replication, synthesis of RNA primer
AL543_10940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL543_10945	COG0359	binds to the 23S rRNA
AL543_10955	COG0305	Participates in initiation and elongation during chromosome replication
AL543_10960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL543_10965	COG0432	Pfam Uncharacterised protein family UPF0047
AL543_10970	COG0166	Belongs to the GPI family
AL543_10980	COG0735	belongs to the Fur family
AL543_10985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL543_11010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL543_11015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL543_11020	COG0175	sulfate reduction
AL543_11095	COG1410	methionine synthase
AL543_11095	COG0646	methionine synthase
AL543_11100	COG0527	aspartate kinase activity
AL543_11105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL543_11115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL543_11135	COG2200	EAL domain
AL543_11135	COG2199	diguanylate cyclase activity
AL543_11160	COG3409	Peptidoglycan-binding domain 1 protein
AL543_11160	COG3267	Type II secretory pathway component ExeA
AL543_11170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL543_11175	COG1459	type II secretion system
AL543_11220	COG1077	Cell shape determining protein MreB Mrl
AL543_11225	COG1792	Involved in formation and maintenance of cell shape
AL543_11230	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL543_11235	COG0424	maF-like protein
AL543_11240	COG1530	ribonuclease E activity
AL543_11245	COG3164	Protein of unknown function
AL543_11250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL543_11255	COG0312	modulator of DNA gyrase
AL543_11260	COG1151	hydroxylamine reductase activity
AL543_11265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL543_11270	COG2235	arginine
AL543_11280	COG1737	Transcriptional regulator
AL543_11280	COG0837	glucose binding
AL543_11290	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AL543_11295	COG3335	DDE superfamily endonuclease
AL543_11310	COG4145	pantothenate transmembrane transporter activity
AL543_11320	COG2706	6-phosphogluconolactonase activity
AL543_11335	COG0589	response to stress
AL543_11350	COG1438	arginine binding
AL543_11355	COG0039	L-malate dehydrogenase activity
AL543_11360	COG0531	amino acid
AL543_11365	COG0142	geranyltranstransferase activity
AL543_11370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL543_11375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL543_11380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL543_11385	COG2966	Psort location CytoplasmicMembrane, score
AL543_11390	COG3610	response to peptide
AL543_11400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL543_11405	COG2967	ApaG domain
AL543_11410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL543_11415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL543_11420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL543_11425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL543_11430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL543_11460	COG0840	transmembrane signaling receptor activity
AL543_11485	COG0741	lytic transglycosylase activity
AL543_11490	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL543_11495	COG1194	a g-specific adenine glycosylase
AL543_11500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL543_11505	COG2066	Belongs to the glutaminase family
AL543_11515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL543_11520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL543_11535	COG0762	integral membrane protein
AL543_11540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL543_11545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL543_11565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL543_11570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL543_11575	COG1678	Uncharacterized ACR, COG1678
AL543_11580	COG0189	ligase activity
AL543_11585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL543_11590	COG2356	endonuclease I
AL543_11595	COG3091	SprT-like family
AL543_11600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL543_11610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL543_11615	COG0583	DNA-binding transcription factor activity
AL543_11620	COG4771	TonB-dependent receptor
AL543_11625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL543_11630	COG0126	phosphoglycerate kinase activity
AL543_11635	COG0191	fructose-bisphosphate aldolase activity
AL543_11640	COG0668	transmembrane transport
AL543_11645	COG1943	Transposase
AL543_11650	COG1279	arginine transmembrane transporter activity
AL543_11655	COG0583	DNA-binding transcription factor activity
AL543_11665	COG0469	pyruvate kinase activity
AL543_11670	COG1349	DNA-binding transcription factor activity
AL543_11675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL543_11680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL543_11695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL543_11700	COG0358	DNA primase activity
AL543_11705	COG1610	YqeY-like protein
AL543_11710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL543_11715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL543_11720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL543_11725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL543_11735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL543_11740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL543_11745	COG1968	undecaprenyl-diphosphatase activity
AL543_11750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL543_11755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL543_11760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL543_11765	COG0585	pseudouridine synthase activity
AL543_11770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL543_11775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL543_11780	COG1388	LysM domain
AL543_11780	COG4942	peptidase
AL543_11785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL543_11790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL543_11810	COG4208	sulfate ABC transporter
AL543_11815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AL543_11820	COG1546	Belongs to the CinA family
AL543_11825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL543_11830	COG2137	regulation of response to DNA damage stimulus
AL543_11835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL543_11840	COG0527	aspartate kinase activity
AL543_11845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AL543_11890	COG3630	sodium ion export across plasma membrane
AL543_11895	COG0511	ligase activity, forming carbon-carbon bonds
AL543_11895	COG5016	pyruvate
AL543_11900	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL543_11910	COG1238	metal cluster binding
AL543_11915	COG0612	Peptidase, M16
AL543_11920	COG2918	glutathione biosynthetic process
AL543_11925	COG1854	S-ribosylhomocysteine lyase activity
AL543_11930	COG4536	flavin adenine dinucleotide binding
AL543_11935	COG4137	Cytochrome C assembly protein
AL543_11940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL543_11945	COG0228	four-way junction DNA binding
AL543_11950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL543_11955	COG0336	Belongs to the RNA methyltransferase TrmD family
AL543_11960	COG0335	large ribosomal subunit rRNA binding
AL543_11965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL543_11970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL543_11980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL543_11990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL543_11995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL543_12000	COG0723	plastoquinol--plastocyanin reductase activity
AL543_12005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL543_12010	COG2857	Cytochrome c1
AL543_12015	COG0625	glutathione transferase activity
AL543_12020	COG2969	positive regulation of protein catabolic process
AL543_12025	COG2823	Periplasmic or secreted lipoprotein
AL543_12030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL543_12035	COG0792	nuclease activity
AL543_12040	COG3107	peptidoglycan biosynthetic process
AL543_12045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL543_12060	COG0288	reversible hydration of carbon dioxide
AL543_12065	COG0659	secondary active sulfate transmembrane transporter activity
AL543_12070	COG1131	(ABC) transporter
AL543_12075	COG0842	Transport permease protein
AL543_12080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL543_12085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL543_12090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL543_12100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL543_12105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL543_12110	COG1489	DNA binding
AL543_12115	COG1643	Atp-dependent helicase
AL543_12120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL543_12125	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL543_12135	COG3112	Uncharacterised protein family (UPF0231)
AL543_12140	COG0347	Belongs to the P(II) protein family
AL543_12145	COG0004	ammonium transporteR
AL543_12150	COG1840	ABC-type Fe3 transport system, periplasmic component
AL543_12160	COG3842	ATPase activity
AL543_12165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL543_12180	COG2971	BadF BadG BcrA BcrD
AL543_12190	COG4608	Belongs to the ABC transporter superfamily
AL543_12195	COG0444	Belongs to the ABC transporter superfamily
AL543_12200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_12210	COG0747	negative chemotaxis
AL543_12220	COG2813	Specifically methylates the guanine in position
AL543_12225	COG0628	permease
AL543_12235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL543_12245	COG0316	Belongs to the HesB IscA family
AL543_12260	COG0739	heme binding
AL543_12265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL543_12270	COG2027	D-alanyl-D-alanine carboxypeptidase
AL543_12275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL543_12280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL543_12285	COG1534	Rna-binding protein
AL543_12290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL543_12295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL543_12300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL543_12305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL543_12315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL543_12330	COG0779	Required for maturation of 30S ribosomal subunits
AL543_12335	COG0195	Participates in both transcription termination and antitermination
AL543_12340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL543_12345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL543_12350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL543_12355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL543_12360	COG1185	polyribonucleotide nucleotidyltransferase activity
AL543_12365	COG4785	May be involved in cell division
AL543_12370	COG1846	Transcriptional regulator
AL543_12400	COG3153	acetyltransferase
AL543_12420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL543_12425	COG0513	Belongs to the DEAD box helicase family
AL543_12430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL543_12445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL543_12450	COG2204	response regulator
AL543_12465	COG0667	Aldo Keto reductase
AL543_12475	COG3066	DNA modification
AL543_12480	COG0494	nUDIX hydrolase
AL543_12485	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AL543_12490	COG0730	response to heat
AL543_12495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL543_12500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL543_12505	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL543_12510	COG3335	DDE superfamily endonuclease
AL543_12515	COG0583	DNA-binding transcription factor activity
AL543_12520	COG0640	Transcriptional regulator
AL543_12525	COG0268	Binds directly to 16S ribosomal RNA
AL543_12530	COG0728	peptidoglycan biosynthetic process
AL543_12535	COG0196	riboflavin kinase activity
AL543_12540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL543_12545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL543_12550	COG1047	Peptidyl-prolyl cis-trans
AL543_12555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL543_12560	COG1966	Carbon starvation protein
AL543_12575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL543_12580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL543_12585	COG1472	Belongs to the glycosyl hydrolase 3 family
AL543_12590	COG3279	Response regulator of the LytR AlgR family
AL543_12595	COG3275	phosphorelay sensor kinase activity
AL543_12600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL543_12605	COG1605	Chorismate mutase
AL543_12605	COG0287	Prephenate dehydrogenase
AL543_12615	COG0488	(ABC) transporter
AL543_12625	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL543_12630	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL543_12635	COG5001	Diguanylate cyclase
AL543_12640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL543_12645	COG1605	Chorismate mutase
AL543_12645	COG0077	Prephenate dehydratase
AL543_12650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL543_12655	COG1943	Transposase
AL543_12660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL543_12665	COG0564	pseudouridine synthase activity
AL543_12675	COG0542	response to heat
AL543_12765	COG4771	TonB-dependent receptor
AL543_12770	COG4821	SIS domain
AL543_12785	COG0745	RESPONSE REGULATOR receiver
AL543_12815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL543_12825	COG2974	May be involved in recombination
AL543_12830	COG0745	RESPONSE REGULATOR receiver
AL543_12835	COG5002	protein histidine kinase activity
AL543_12845	COG0248	Ppx GppA phosphatase
AL543_12850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL543_12860	COG0581	inorganic phosphate transmembrane transporter activity
AL543_12865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL543_12880	COG3142	Participates in the control of copper homeostasis
AL543_12885	COG0450	alkyl hydroperoxide reductase
AL543_12890	COG0583	DNA-binding transcription factor activity
AL543_12895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL543_12905	COG0517	IMP dehydrogenase activity
AL543_12910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL543_12920	COG0343	queuine tRNA-ribosyltransferase activity
AL543_12925	COG1862	Preprotein translocase
AL543_12930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_12935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL543_12940	COG0483	inositol monophosphate 1-phosphatase activity
AL543_12950	COG1959	2 iron, 2 sulfur cluster binding
AL543_12960	COG0822	iron-sulfur transferase activity
AL543_12970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL543_12980	COG0633	Ferredoxin
AL543_12985	COG2975	iron-sulfur cluster assembly
AL543_12990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL543_12995	COG0105	UTP biosynthetic process
AL543_13000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL543_13005	COG1426	Protein conserved in bacteria
AL543_13010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL543_13015	COG0124	histidyl-tRNA synthetase
AL543_13020	COG2976	Protein conserved in bacteria
AL543_13025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL543_13030	COG1160	GTP binding
AL543_13045	COG1570	exodeoxyribonuclease VII activity
AL543_13050	COG0516	GMP reductase activity
AL543_13050	COG0517	IMP dehydrogenase activity
AL543_13055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL543_13055	COG0519	Catalyzes the synthesis of GMP from XMP
AL543_13060	COG0582	viral genome integration into host DNA
AL543_13070	COG0210	DNA helicase
AL543_13135	COG3335	DDE superfamily endonuclease
AL543_13175	COG1584	GPR1 FUN34 yaaH family protein
AL543_13180	COG1943	Transposase
AL543_13185	COG0583	DNA-binding transcription factor activity
AL543_13195	COG1115	amino acid carrier protein
AL543_13200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL543_13205	COG0583	DNA-binding transcription factor activity
AL543_13220	COG2200	EAL domain
AL543_13230	COG4565	transcriptional regulatory protein
AL543_13240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL543_13245	COG5016	pyruvate
AL543_13245	COG0511	ligase activity, forming carbon-carbon bonds
AL543_13250	COG3630	sodium ion export across plasma membrane
AL543_13260	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AL543_13265	COG3052	prosthetic group binding
AL543_13270	COG2301	Belongs to the HpcH HpaI aldolase family
AL543_13275	COG3051	citrate lyase alpha subunit
AL543_13280	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
AL543_13285	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AL543_13295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL543_13300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL543_13305	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AL543_13320	COG3335	DDE superfamily endonuclease
AL543_13335	COG3335	DDE superfamily endonuclease
AL543_13345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL543_13375	COG0582	viral genome integration into host DNA
AL543_13385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL543_13390	COG2867	negative regulation of translational initiation
AL543_13395	COG2914	Belongs to the UPF0125 (RnfH) family
AL543_13400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL543_13405	COG0497	DNA recombination
AL543_13410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL543_13415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL543_13420	COG0443	Heat shock 70 kDa protein
AL543_13425	COG0484	heat shock protein binding
AL543_13460	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL543_13465	COG0590	tRNA wobble adenosine to inosine editing
AL543_13475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL543_13485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL543_13485	COG0047	phosphoribosylformylglycinamidine synthase activity
AL543_13505	COG0442	prolyl-tRNA aminoacylation
AL543_13510	COG1720	tRNA m6t6A37 methyltransferase activity
AL543_13515	COG0254	rRNA binding
AL543_13520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL543_13525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL543_13530	COG1671	Belongs to the UPF0178 family
AL543_13560	COG0564	pseudouridine synthase activity
AL543_13565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL543_13570	COG0142	geranyltranstransferase activity
AL543_13575	COG1722	exodeoxyribonuclease VII activity
AL543_13580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL543_13590	COG0301	tRNA thio-modification
AL543_13590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL543_13600	COG0583	DNA-binding transcription factor activity
AL543_13605	COG2363	Small membrane protein
AL543_13610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL543_13615	COG1611	Belongs to the LOG family
AL543_13620	COG3706	GGDEF domain
AL543_13630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL543_13630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL543_13640	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL543_13645	COG1464	Belongs to the NlpA lipoprotein family
AL543_13650	COG2011	ABC-type metal ion transport system permease component
AL543_13655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL543_13660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL543_13665	COG1609	Transcriptional regulator
AL543_13670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_13670	COG1263	PTS System
AL543_13675	COG0366	Alpha amylase catalytic
AL543_13680	COG0745	RESPONSE REGULATOR receiver
AL543_13685	COG2205	protein histidine kinase activity
AL543_13720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_13730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL543_13735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL543_13740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL543_13765	COG1045	serine acetyltransferase
AL543_13785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL543_13815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL543_13825	COG1596	polysaccharide export
AL543_13850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL543_13860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL543_13865	COG0321	lipoyl(octanoyl) transferase activity
AL543_13870	COG2921	Belongs to the UPF0250 family
AL543_13875	COG1686	Belongs to the peptidase S11 family
AL543_13880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL543_13885	COG0772	Belongs to the SEDS family
AL543_13890	COG0768	penicillin binding
AL543_13895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL543_13900	COG0799	negative regulation of ribosome biogenesis
AL543_13905	COG1466	dna polymerase III delta subunit
AL543_13910	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL543_13915	COG0495	leucyl-tRNA aminoacylation
AL543_13920	COG2888	peptidyl-tyrosine sulfation
AL543_13925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL543_13930	COG4535	Mg2 and Co2 transporter CorC
AL543_13935	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL543_13940	COG1702	phosphate starvation-inducible protein PhoH
AL543_13945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL543_13950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL543_13955	COG2190	(PTS) system
AL543_13965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_13975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL543_13980	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL543_13985	COG3115	cell septum assembly
AL543_13990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL543_14005	COG0789	Transcriptional regulator
AL543_14010	COG3385	transposase activity
AL543_14015	COG1585	Membrane protein implicated in regulation of membrane protease activity
AL543_14020	COG0330	HflC and HflK could
AL543_14025	COG3118	belongs to the thioredoxin family
AL543_14030	COG0300	oxidoreductase activity
AL543_14035	COG1090	epimerase
AL543_14040	COG0622	Phosphoesterase
AL543_14055	COG3710	Transcriptional regulator
AL543_14060	COG0326	Molecular chaperone. Has ATPase activity
AL543_14065	COG0563	adenylate kinase activity
AL543_14070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL543_14080	COG0250	Participates in transcription elongation, termination and antitermination
AL543_14085	COG0367	asparagine synthase
AL543_14090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL543_14090	COG4651	solute:proton antiporter activity
AL543_14095	COG1940	carbohydrate kinase activity
AL543_14095	COG1846	Transcriptional regulator
AL543_14100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL543_14105	COG2190	(PTS) system
AL543_14105	COG1263	PTS System
AL543_14105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_14110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL543_14120	COG0101	tRNA pseudouridine synthase activity
AL543_14130	COG0285	dihydrofolate synthase activity
AL543_14135	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL543_14140	COG1286	toxin biosynthetic process
AL543_14145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL543_14150	COG2056	Na+-H+ antiporter family
AL543_14155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL543_14170	COG0346	lactoylglutathione lyase activity
AL543_14175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL543_14180	COG4660	Part of a membrane complex involved in electron transport
AL543_14185	COG4659	FMN binding
AL543_14190	COG4658	electron transport chain
AL543_14195	COG4656	Part of a membrane complex involved in electron transport
AL543_14200	COG2878	Part of a membrane complex involved in electron transport
AL543_14205	COG4657	Part of a membrane complex involved in electron transport
AL543_14210	COG1943	Transposase
AL543_14220	COG0556	nucleotide-excision repair
AL543_14225	COG2204	response regulator
AL543_14230	COG2198	Histidine kinase
AL543_14235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL543_14240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL543_14245	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL543_14250	COG0315	cyclic pyranopterin monophosphate synthase activity
AL543_14255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL543_14260	COG0314	molybdopterin synthase activity
AL543_14275	COG0516	GMP reductase activity
AL543_14275	COG0517	IMP dehydrogenase activity
AL543_14285	COG3335	DDE superfamily endonuclease
AL543_14290	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL543_14300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_14300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_14310	COG0572	uridine kinase
AL543_14315	COG2982	Protein involved in outer membrane biogenesis
AL543_14320	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL543_14325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL543_14330	COG2067	long-chain fatty acid transport protein
AL543_14335	COG2067	long-chain fatty acid transport protein
AL543_14350	COG0183	Belongs to the thiolase family
AL543_14355	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL543_14355	COG1024	Enoyl-CoA hydratase
AL543_14360	COG0778	Nitroreductase
AL543_14365	COG0583	DNA-binding transcription factor activity
AL543_14370	COG0745	RESPONSE REGULATOR receiver
AL543_14380	COG2832	Protein of unknown function (DUF454)
AL543_14385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL543_14395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL543_14400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL543_14415	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_14420	COG0616	signal peptide processing
AL543_14430	COG1522	sequence-specific DNA binding
AL543_14435	COG1946	Acyl-CoA thioesterase
AL543_14455	COG5001	Diguanylate cyclase
AL543_14455	COG3300	MHYT domain
AL543_14510	COG4264	IucA IucC family
AL543_14520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL543_14525	COG1120	ATPase activity
AL543_14555	COG0662	Cupin 2, conserved barrel domain protein
AL543_14560	COG1960	acyl-CoA dehydrogenase activity
AL543_14565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL543_14570	COG2076	Multidrug Resistance protein
AL543_14575	COG2076	Multidrug Resistance protein
AL543_14580	COG0590	tRNA wobble adenosine to inosine editing
AL543_14590	COG0640	Transcriptional regulator
AL543_14595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL543_14610	COG1349	DNA-binding transcription factor activity
AL543_14615	COG1349	DNA-binding transcription factor activity
AL543_14625	COG2222	sugar isomerase
AL543_14630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_14635	COG3715	PTS system
AL543_14640	COG3716	PTS system mannose fructose sorbose family IID component
AL543_14645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_14665	COG3335	DDE superfamily endonuclease
AL543_14690	COG1881	PFAM PEBP family protein
AL543_14710	COG0009	L-threonylcarbamoyladenylate synthase
AL543_14725	COG2201	protein-glutamate methylesterase activity
AL543_14735	COG5002	protein histidine kinase activity
AL543_14740	COG4191	Histidine kinase
AL543_14745	COG3300	MHYT domain
AL543_14745	COG5001	Diguanylate cyclase
AL543_14750	COG2204	response regulator
AL543_14770	COG0601	transmembrane transport
AL543_14775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL543_14785	COG4608	Belongs to the ABC transporter superfamily
AL543_14790	COG0435	Glutathione S-transferase
AL543_14795	COG0280	phosphate acetyltransferase
AL543_14795	COG0857	belongs to the CobB CobQ family
AL543_14800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL543_14805	COG3092	negative regulation of chromosome organization
AL543_14810	COG4628	conserved protein (DUF2132)
AL543_14820	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL543_14830	COG3706	GGDEF domain
AL543_14835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL543_14845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL543_14850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL543_14855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL543_14860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL543_14865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL543_14870	COG0156	8-amino-7-oxononanoate synthase activity
AL543_14875	COG2226	methyltransferase
AL543_14880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL543_14890	COG0501	Belongs to the peptidase M48B family
AL543_14900	COG0300	oxidoreductase activity
AL543_14915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL543_14925	COG2268	Band 7 protein
AL543_14935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL543_14940	COG2915	High frequency lysogenization protein hflD homolog
AL543_14945	COG0482	sulfurtransferase activity
AL543_14950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL543_14955	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL543_14960	COG1757	Na H antiporter
AL543_14965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL543_14970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL543_14975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL543_14980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL543_14980	COG0131	Imidazoleglycerol-phosphate dehydratase
AL543_14985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL543_14990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL543_14995	COG0107	imidazoleglycerol-phosphate synthase activity
AL543_15000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL543_15000	COG0140	phosphoribosyl-ATP diphosphatase activity
AL543_15005	COG1187	pseudouridine synthase activity
AL543_15015	COG1278	Cold shock
AL543_15020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL543_15025	COG0542	response to heat
AL543_15035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL543_15045	COG1979	alcohol dehydrogenase
AL543_15050	COG1737	Transcriptional regulator
AL543_15055	COG0076	glutamate decarboxylase activity
AL543_15065	COG2431	L-lysine efflux transmembrane transporter activity
AL543_15075	COG3070	regulator of competence-specific genes
AL543_15095	COG3852	Histidine kinase
AL543_15105	COG3385	transposase activity
AL543_15110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL543_15125	COG0189	ligase activity
AL543_15125	COG4067	protein conserved in archaea
AL543_15130	COG0500	methyltransferase
AL543_15135	COG4106	trans-aconitate 2-methyltransferase activity
AL543_15140	COG1801	Protein of unknown function DUF72
AL543_15145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL543_15150	COG1435	thymidine kinase activity
AL543_15160	COG0159	tryptophan synthase activity
AL543_15165	COG0133	tryptophan synthase activity
AL543_15170	COG0134	indole-3-glycerol-phosphate synthase activity
AL543_15170	COG0135	phosphoribosylanthranilate isomerase activity
AL543_15175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL543_15180	COG0512	Glutamine amidotransferase of anthranilate synthase
AL543_15185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL543_15195	COG0613	PHP domain protein
AL543_15200	COG0009	L-threonylcarbamoyladenylate synthase
AL543_15205	COG1187	pseudouridine synthase activity
AL543_15210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL543_15215	COG4988	ABC transporter
AL543_15220	COG0492	ferredoxin-NADP+ reductase activity
AL543_15230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL543_15235	COG3706	GGDEF domain
AL543_15240	COG2949	membrane
AL543_15250	COG0281	malic enzyme
AL543_15260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL543_15280	COG2885	chlorophyll binding
AL543_15295	COG0247	lactate metabolic process
AL543_15295	COG0277	FAD linked oxidase domain protein
AL543_15315	COG2986	histidine ammonia-lyase
AL543_15320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL543_15325	COG0010	Belongs to the arginase family
AL543_15330	COG1228	amidohydrolase
AL543_15350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL543_15360	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL543_15365	COG0417	DNA replication proofreading
AL543_15370	COG2197	response regulator
AL543_15375	COG0322	excinuclease ABC activity
AL543_15405	COG1943	Transposase
AL543_15410	COG3335	DDE superfamily endonuclease
AL543_15420	COG0456	acetyltransferase
AL543_15425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL543_15430	COG0072	phenylalanine-tRNA ligase activity
AL543_15430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL543_15435	COG0776	regulation of translation
AL543_15455	COG0500	methyltransferase
AL543_15470	COG0295	cytidine deaminase activity
AL543_15475	COG1346	cytolysis
AL543_15485	COG2925	Exonuclease
AL543_15495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_15500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL543_15505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL543_15520	COG2988	succinylglutamate desuccinylase activity
AL543_15525	COG4139	cobalamin transport
AL543_15530	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL543_15545	COG0840	transmembrane signaling receptor activity
AL543_15580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL543_15585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL543_15610	COG0437	4 iron, 4 sulfur cluster binding
AL543_15615	COG3301	Polysulphide reductase, NrfD
AL543_15620	COG1138	Cytochrome C-type biogenesis protein
AL543_15630	COG3088	subunit of a heme lyase
AL543_15630	COG4235	cytochrome complex assembly
AL543_15640	COG1278	Cold shock
AL543_15670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL543_15700	COG3108	Peptidase M15
AL543_15705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL543_15720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL543_15745	COG1846	Transcriptional regulator
AL543_15750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL543_15755	COG0726	polysaccharide deacetylase
AL543_15760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL543_15770	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL543_15775	COG1486	melibiose metabolic process
AL543_15780	COG3394	polysaccharide catabolic process
AL543_15790	COG2943	transferase activity, transferring hexosyl groups
AL543_15795	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AL543_15815	COG1448	Aminotransferase
AL543_15820	COG3437	response regulator, receiver
AL543_15820	COG2770	Histidine kinase
AL543_15825	COG0110	maltose O-acetyltransferase activity
AL543_15830	COG0351	phosphomethylpyrimidine kinase
AL543_15835	COG0017	Asparaginyl-tRNA synthetase
AL543_15840	COG0840	transmembrane signaling receptor activity
AL543_15845	COG0720	synthase
AL543_15850	COG1760	l-serine dehydratase
AL543_15855	COG0814	amino acid
AL543_15860	COG0494	nUDIX hydrolase
AL543_15880	COG3106	COG3106 Predicted ATPase
AL543_15885	COG3768	UPF0283 membrane protein
AL543_15890	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AL543_15895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL543_15915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL543_15920	COG0840	transmembrane signaling receptor activity
AL543_15925	COG0471	metal ion transport
AL543_15930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_15930	COG4191	Histidine kinase
AL543_15945	COG3713	MltA-interacting MipA family protein
AL543_15950	COG5002	protein histidine kinase activity
AL543_15955	COG0745	RESPONSE REGULATOR receiver
AL543_15975	COG3335	DDE superfamily endonuclease
AL543_15990	COG1129	ABC transporter
AL543_16035	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL543_16040	COG0372	Belongs to the citrate synthase family
AL543_16070	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_16080	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL543_16090	COG0625	glutathione transferase activity
AL543_16095	COG3437	response regulator, receiver
AL543_16110	COG3335	DDE superfamily endonuclease
AL543_16115	COG3706	GGDEF domain
AL543_16120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL543_16130	COG1254	Belongs to the acylphosphatase family
AL543_16135	COG2920	part of a sulfur-relay system
AL543_16140	COG0670	Belongs to the BI1 family
AL543_16145	COG1126	abc transporter atp-binding protein
AL543_16150	COG0765	amino acid transport
AL543_16155	COG4597	amino acid ABC transporter
AL543_16160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL543_16170	COG0561	phosphatase activity
AL543_16175	COG0602	queuosine metabolic process
AL543_16180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL543_16210	COG3706	GGDEF domain
AL543_16215	COG0443	Heat shock 70 kDa protein
AL543_16220	COG0443	Heat shock 70 kDa protein
AL543_16230	COG3300	MHYT domain
AL543_16230	COG5001	Diguanylate cyclase
AL543_16260	COG1643	Atp-dependent helicase
AL543_16270	COG0754	glutathionylspermidine amidase activity
AL543_16285	COG3335	DDE superfamily endonuclease
AL543_16305	COG0402	S-adenosylhomocysteine deaminase activity
AL543_16310	COG0443	Heat shock 70 kDa protein
AL543_16315	COG0583	DNA-binding transcription factor activity
AL543_16320	COG0477	Major facilitator Superfamily
AL543_16325	COG2076	Multidrug Resistance protein
AL543_16340	COG0513	Belongs to the DEAD box helicase family
AL543_16360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL543_16400	COG1846	Transcriptional regulator
AL543_16420	COG3971	2-oxopent-4-enoate hydratase activity
AL543_16440	COG1012	belongs to the aldehyde dehydrogenase family
AL543_16455	COG3384	dioxygenase
AL543_16460	COG1012	belongs to the aldehyde dehydrogenase family
AL543_16470	COG1960	acyl-CoA dehydrogenase activity
AL543_16475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL543_16485	COG3501	Rhs element vgr protein
AL543_16505	COG1280	lysine exporter protein (LysE YggA)
AL543_16510	COG1115	amino acid carrier protein
AL543_16525	COG2199	diguanylate cyclase activity
AL543_16530	COG2205	protein histidine kinase activity
AL543_16530	COG2202	Pas domain
AL543_16545	COG1012	belongs to the aldehyde dehydrogenase family
AL543_16550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL543_16555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL543_16560	COG1177	transmembrane transport
AL543_16565	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL543_16570	COG3842	ATPase activity
AL543_16575	COG3335	DDE superfamily endonuclease
AL543_16595	COG0037	tRNA processing
AL543_16600	COG0589	response to stress
AL543_16605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL543_16620	COG2217	Heavy metal translocating P-type atpase
AL543_16630	COG2010	Cytochrome c
AL543_16645	COG3278	Belongs to the heme-copper respiratory oxidase family
AL543_16660	COG0784	Response regulator, receiver
AL543_16660	COG5002	protein histidine kinase activity
AL543_16685	COG3120	sequence-specific DNA binding
AL543_16690	COG1067	ATP-dependent peptidase activity
AL543_16695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL543_16720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL543_16720	COG0116	Belongs to the methyltransferase superfamily
AL543_16730	COG0167	dihydroorotate dehydrogenase activity
AL543_16745	COG0308	aminopeptidase N
AL543_16760	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL543_16765	COG1956	GAF domain-containing protein
AL543_16775	COG2995	paraquat-inducible protein a
AL543_16780	COG3008	intermembrane lipid transfer
AL543_16785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL543_16785	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AL543_16790	COG2996	Protein conserved in bacteria
AL543_16805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL543_16815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL543_16820	COG0004	ammonium transporteR
AL543_16840	COG0437	4 iron, 4 sulfur cluster binding
AL543_16845	COG0243	molybdopterin cofactor binding
AL543_16845	COG3383	formate dehydrogenase (NAD+) activity
AL543_16875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL543_16885	COG0488	(ABC) transporter
AL543_16890	COG3852	Histidine kinase
AL543_16905	COG4662	Binding-protein-dependent transport system inner membrane component
AL543_16910	COG3842	ATPase activity
AL543_16915	COG0746	molybdenum cofactor guanylyltransferase activity
AL543_16920	COG0303	'Molybdopterin
AL543_16930	COG1940	carbohydrate kinase activity
AL543_16945	COG0840	transmembrane signaling receptor activity
AL543_16950	COG0791	NLP P60 protein
AL543_16970	COG0534	Mate efflux family protein
AL543_16980	COG1793	dna ligase
AL543_16995	COG0848	biopolymer transport protein
AL543_17000	COG0811	peptide transport
AL543_17005	COG0811	peptide transport
AL543_17020	COG1653	transport
AL543_17025	COG1175	transmembrane transport
AL543_17030	COG0395	ABC-type sugar transport system, permease component
AL543_17035	COG3842	ATPase activity
AL543_17045	COG0584	glycerophosphoryl diester phosphodiesterase
AL543_17050	COG2731	YhcH YjgK YiaL family protein
AL543_17060	COG1609	Transcriptional regulator
AL543_17065	COG2723	6-phospho-beta-galactosidase activity
AL543_17070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL543_17095	COG0577	efflux transmembrane transporter activity
AL543_17100	COG0577	efflux transmembrane transporter activity
AL543_17100	COG1136	(ABC) transporter
AL543_17105	COG0577	efflux transmembrane transporter activity
AL543_17105	COG1136	(ABC) transporter
AL543_17115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL543_17120	COG1780	Probably involved in ribonucleotide reductase function
AL543_17135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL543_17140	COG0719	Fe-S assembly protein
AL543_17145	COG0396	ATPase activity
AL543_17150	COG0719	Fe-S assembly protein
AL543_17155	COG0316	Belongs to the HesB IscA family
AL543_17200	COG0753	catalase activity
AL543_17210	COG3064	Membrane
AL543_17220	COG2017	converts alpha-aldose to the beta-anomer
AL543_17225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL543_17230	COG1085	galactose-1-phosphate uridylyltransferase
AL543_17250	COG3706	GGDEF domain
AL543_17250	COG0745	RESPONSE REGULATOR receiver
AL543_17265	COG0835	chemotaxis
AL543_17265	COG0784	Response regulator, receiver
AL543_17275	COG4565	transcriptional regulatory protein
AL543_17280	COG3290	protein histidine kinase activity
AL543_17295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_17315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL543_17320	COG3063	Type IV pilus biogenesis stability protein PilW
AL543_17335	COG1451	nucleotide metabolic process
AL543_17345	COG0583	DNA-binding transcription factor activity
AL543_17365	COG1538	Outer membrane efflux protein
AL543_17375	COG0019	diaminopimelate decarboxylase activity
AL543_17380	COG1748	Saccharopine dehydrogenase
AL543_17390	COG3335	DDE superfamily endonuclease
AL543_17395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL543_17410	COG4181	ATPase activity
AL543_17415	COG0534	Mate efflux family protein
AL543_17420	COG0702	epimerase
AL543_17430	COG2814	Major facilitator Superfamily
AL543_17435	COG1187	pseudouridine synthase activity
AL543_17440	COG1061	Type III restriction enzyme res subunit
AL543_17450	COG0745	RESPONSE REGULATOR receiver
AL543_17460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL543_17510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL543_17535	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AL543_17555	COG4934	collagen metabolic process
AL543_17570	COG0784	Response regulator, receiver
AL543_17570	COG2205	protein histidine kinase activity
AL543_17575	COG2239	Acts as a magnesium transporter
AL543_17585	COG0814	amino acid
AL543_17590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_17595	COG1131	(ABC) transporter
AL543_17600	COG0842	Transport permease protein
AL543_17610	COG3313	Fe-S protein
AL543_17620	COG4134	Bacterial extracellular solute-binding protein
AL543_17625	COG4135	transport system, permease component
AL543_17630	COG4136	ATPase activity
AL543_17635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL543_17640	COG0564	pseudouridine synthase activity
AL543_17645	COG0733	neurotransmitter:sodium symporter activity
AL543_17660	COG2818	Glycosylase
AL543_17665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL543_17680	COG1842	Phage shock protein A
AL543_17685	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL543_17695	COG4168	peptide transport system, permease
AL543_17700	COG4171	peptide transport system, permease
AL543_17710	COG4172	Belongs to the ABC transporter superfamily
AL543_17725	COG1227	inorganic diphosphatase activity
AL543_17735	COG1162	GTPase activity
AL543_17745	COG1943	Transposase
AL543_17750	COG1943	Transposase
AL543_17755	COG0243	molybdopterin cofactor binding
AL543_17760	COG3005	denitrification pathway
AL543_17765	COG4459	periplasmic nitrate reductase
AL543_17775	COG2116	formate transmembrane transporter activity
AL543_17785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL543_17790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL543_17805	COG2917	probably involved in intracellular septation
AL543_17810	COG1607	acyl-coa hydrolase
AL543_17815	COG2350	Protein conserved in bacteria
AL543_17825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL543_17830	COG0583	DNA-binding transcription factor activity
AL543_17845	COG0612	Peptidase, M16
AL543_17850	COG2199	diguanylate cyclase activity
AL543_17850	COG2203	Gaf domain
AL543_17850	COG2200	EAL domain
AL543_17855	COG1032	radical SAM domain protein
AL543_17870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL543_17875	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL543_17880	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL543_17885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL543_17890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL543_17895	COG0745	RESPONSE REGULATOR receiver
AL543_17900	COG3381	protein complex oligomerization
AL543_17905	COG1609	Transcriptional regulator
AL543_17910	COG3070	regulator of competence-specific genes
AL543_17930	COG0297	glycogen (starch) synthase activity
AL543_17935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL543_17940	COG1943	Transposase
AL543_17945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL543_17955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL543_17965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL543_17970	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL543_17975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL543_17980	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL543_17985	COG1960	acyl-CoA dehydrogenase activity
AL543_18005	COG1012	belongs to the aldehyde dehydrogenase family
AL543_18010	COG1309	transcriptional regulator
AL543_18015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL543_18025	COG3335	DDE superfamily endonuclease
AL543_18030	COG2200	EAL domain
AL543_18030	COG2771	luxR family
AL543_18040	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL543_18045	COG3069	C4-dicarboxylate transmembrane transporter activity
AL543_18110	COG4964	Belongs to the GSP D family
AL543_18155	COG0641	radical SAM
AL543_18160	COG0583	DNA-binding transcription factor activity
AL543_18195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_18200	COG3537	Alpha-1,2-mannosidase
AL543_18210	COG3537	Alpha-1,2-mannosidase
AL543_18215	COG3537	Alpha-1,2-mannosidase
AL543_18225	COG3537	Alpha-1,2-mannosidase
AL543_18235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL543_18240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_18245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_18255	COG2207	Transcriptional regulator
AL543_18260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_18260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL543_18260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL543_18275	COG5002	protein histidine kinase activity
AL543_18275	COG0784	Response regulator, receiver
AL543_18285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL543_18295	COG2885	chlorophyll binding
AL543_18300	COG0823	Involved in the tonB-independent uptake of proteins
AL543_18315	COG0811	peptide transport
AL543_18320	COG0824	Thioesterase
AL543_18330	COG4890	Cyd operon protein YbgT
AL543_18335	COG1294	oxidase, subunit
AL543_18340	COG1271	oxidase subunit
AL543_18345	COG2255	four-way junction helicase activity
AL543_18350	COG0632	four-way junction helicase activity
AL543_18355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL543_18360	COG0215	cysteine-tRNA ligase activity
AL543_18365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL543_18370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL543_18375	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL543_18400	COG1199	ATP-dependent helicase activity
AL543_18405	COG0730	response to heat
AL543_18410	COG3923	Primosomal replication protein n
AL543_18420	COG0840	transmembrane signaling receptor activity
AL543_18425	COG0708	Exodeoxyribonuclease III
AL543_18430	COG4160	amino acid transport
AL543_18435	COG4215	(ABC) transporter
AL543_18455	COG1882	Formate acetyltransferase
AL543_18465	COG0840	transmembrane signaling receptor activity
AL543_18470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL543_18480	COG3013	Belongs to the UPF0304 family
AL543_18485	COG2766	serine protein kinase
AL543_18490	COG2718	Belongs to the UPF0229 family
AL543_18495	COG2719	SpoVR family
AL543_18505	COG0745	RESPONSE REGULATOR receiver
AL543_18520	COG3385	transposase activity
AL543_18525	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL543_18535	COG1663	tetraacyldisaccharide 4'-kinase activity
AL543_18540	COG1132	(ABC) transporter
AL543_18545	COG2333	competence protein COMEC
AL543_18545	COG0658	competence protein
AL543_18555	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL543_18560	COG1136	(ABC) transporter
AL543_18565	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL543_18575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL543_18590	COG1252	NADH dehydrogenase
AL543_18620	COG0537	adenosine 5'-monophosphoramidase activity
AL543_18635	COG2186	Transcriptional regulator
AL543_18640	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL543_18645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL543_18650	COG1674	ftsk spoiiie
AL543_18655	COG1522	sequence-specific DNA binding
AL543_18660	COG0686	Belongs to the AlaDH PNT family
AL543_18670	COG0583	DNA-binding transcription factor activity
AL543_18685	COG1943	Transposase
AL543_18700	COG4608	Belongs to the ABC transporter superfamily
AL543_18705	COG0444	Belongs to the ABC transporter superfamily
AL543_18710	COG4166	transmembrane transport
AL543_18715	COG4239	(ABC) transporter, permease
AL543_18720	COG4174	ABC transporter (Permease)
AL543_18765	COG2204	response regulator
AL543_18775	COG0438	transferase activity, transferring glycosyl groups
AL543_18810	COG0438	transferase activity, transferring glycosyl groups
AL543_18815	COG1215	transferase activity, transferring glycosyl groups
AL543_18820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL543_18835	COG0284	orotidine-5'-phosphate decarboxylase activity
AL543_18840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL543_18845	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL543_18850	COG0776	regulation of translation
AL543_18855	COG0539	negative regulation of cytoplasmic translation
AL543_18860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL543_18865	COG1555	photosystem II stabilization
AL543_18870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL543_18875	COG0776	regulation of translation
AL543_18880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL543_18885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL543_18895	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL543_18905	COG4191	Histidine kinase
AL543_18915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL543_18920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL543_18925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL543_18930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL543_18945	COG3300	MHYT domain
AL543_18945	COG5001	Diguanylate cyclase
AL543_18955	COG4589	Belongs to the CDS family
AL543_18970	COG0671	phosphoesterase, PA-phosphatase related
AL543_18985	COG3842	ATPase activity
AL543_19015	COG3293	Transposase
AL543_19035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL543_19045	COG3325	Belongs to the glycosyl hydrolase 18 family
AL543_19045	COG3469	chitinase activity
AL543_19050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL543_19060	COG2951	lytic endotransglycosylase activity
AL543_19065	COG3100	YcgL domain-containing protein
AL543_19070	COG0850	regulation of cytokinetic process
AL543_19075	COG2894	cell division
AL543_19080	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL543_19085	COG3015	lipoprotein NlpE involved in copper resistance
AL543_19105	COG0477	Major facilitator Superfamily
AL543_19115	COG1396	sequence-specific DNA binding
AL543_19120	COG3135	benzoate transporter
AL543_19130	COG1441	menaquinone biosynthetic process
AL543_19140	COG0596	Alpha beta hydrolase
AL543_19145	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL543_19150	COG1169	isochorismate synthase
AL543_19155	COG0436	Aminotransferase
AL543_19160	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL543_19165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL543_19175	COG0705	Rhomboid family
AL543_19185	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL543_19190	COG0318	PFAM AMP-dependent synthetase and ligase
AL543_19195	COG0596	Alpha beta hydrolase
AL543_19210	COG1214	PFAM Peptidase M22, glycoprotease
AL543_19215	COG1199	ATP-dependent helicase activity
AL543_19225	COG0788	formyltetrahydrofolate deformylase activity
AL543_19230	COG1902	pentaerythritol trinitrate reductase activity
AL543_19230	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL543_19235	COG0616	signal peptide processing
AL543_19240	COG0252	asparaginase activity
AL543_19245	COG3139	Protein of unknown function (DUF1315)
AL543_19255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL543_19260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL543_19275	COG2226	methyltransferase
AL543_19305	COG0835	chemotaxis
AL543_19305	COG0784	Response regulator, receiver
AL543_19310	COG1940	carbohydrate kinase activity
AL543_19320	COG4667	esterase of the alpha-beta hydrolase superfamily
AL543_19330	COG0733	neurotransmitter:sodium symporter activity
AL543_19340	COG1263	PTS System
AL543_19340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL543_19345	COG0084	hydrolase, TatD family'
AL543_19350	COG0470	DNA polymerase III
AL543_19355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL543_19360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL543_19365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL543_19370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL543_19375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL543_19380	COG1028	Short-chain dehydrogenase reductase Sdr
AL543_19390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL543_19395	COG0416	fatty acid biosynthetic process
AL543_19400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL543_19405	COG1399	metal-binding, possibly nucleic acid-binding protein
AL543_19410	COG0424	maF-like protein
AL543_19415	COG0564	pseudouridine synthase activity
AL543_19425	COG1530	ribonuclease E activity
AL543_19430	COG0659	secondary active sulfate transmembrane transporter activity
AL543_19440	COG3385	transposase activity
AL543_19445	COG1454	alcohol dehydrogenase
AL543_19445	COG1012	belongs to the aldehyde dehydrogenase family
AL543_19450	COG2095	MarC family integral membrane protein
AL543_19455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL543_19460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL543_19465	COG1757	Na H antiporter
AL543_19475	COG3081	Nucleoid-associated protein
AL543_19485	COG3083	sulfuric ester hydrolase activity
AL543_19505	COG3335	DDE superfamily endonuclease
AL543_19515	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AL543_19530	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL543_19535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL543_19540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL543_19560	COG2853	Lipoprotein
AL543_19570	COG4235	cytochrome complex assembly
AL543_19570	COG3088	subunit of a heme lyase
AL543_19575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL543_19580	COG1138	Cytochrome C-type biogenesis protein
AL543_19585	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL543_19595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL543_19600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL543_19605	COG4133	protoheme IX ABC transporter activity
AL543_19615	COG0835	chemotaxis
AL543_19625	COG1192	Involved in chromosome partitioning
AL543_19630	COG2201	protein-glutamate methylesterase activity
AL543_19635	COG2198	Histidine kinase
AL543_19635	COG0643	Histidine kinase
AL543_19640	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL543_19655	COG0455	bacterial-type flagellum organization
AL543_19670	COG2062	phosphohistidine phosphatase, SixA
AL543_19675	COG1025	Belongs to the peptidase M16 family
AL543_19685	COG0018	arginyl-trna synthetase
AL543_19705	COG1918	ferrous iron import across plasma membrane
AL543_19710	COG4977	sequence-specific DNA binding
AL543_19715	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL543_19720	COG1121	(ABC) transporter
AL543_19725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL543_19735	COG0045	succinate-CoA ligase (ADP-forming) activity
AL543_19740	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL543_19745	COG0567	Dehydrogenase, E1 component
AL543_19755	COG1053	succinate dehydrogenase
AL543_19760	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL543_19765	COG2009	succinate dehydrogenase
AL543_19770	COG0372	Belongs to the citrate synthase family
AL543_19775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL543_19785	COG0033	Phosphoglucomutase
AL543_19790	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL543_19795	COG0596	Alpha beta hydrolase
AL543_19810	COG1346	cytolysis
AL543_19820	COG0583	DNA-binding transcription factor activity
AL543_19830	COG0735	belongs to the Fur family
AL543_19835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL543_19840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL543_19845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL543_19850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL543_19850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL543_19855	COG0431	NADPH-dependent FMN reductase
AL543_19865	COG3101	peptidyl-lysine hydroxylation
AL543_19870	COG2860	membrane
AL543_19875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL543_19885	COG2890	protein-(glutamine-N5) methyltransferase activity
AL543_19905	COG1987	bacterial-type flagellum assembly
AL543_19950	COG1317	bacterial-type flagellum organization
AL543_19955	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL543_19970	COG2204	response regulator
AL543_19975	COG4191	Histidine kinase
AL543_19980	COG2204	response regulator
AL543_19985	COG1516	flagellar protein fliS
AL543_19995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL543_20000	COG1334	flagellar protein FlaG
AL543_20005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_20010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_20015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_20020	COG2837	iron assimilation
AL543_20040	COG1393	Belongs to the ArsC family
AL543_20045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL543_20050	COG1876	peptidase activity
AL543_20060	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL543_20065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL543_20075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL543_20095	COG4783	chaperone-mediated protein folding
AL543_20100	COG1393	Belongs to the ArsC family
AL543_20120	COG2233	PERMEase
AL543_20125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL543_20130	COG0737	Belongs to the 5'-nucleotidase family
AL543_20135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL543_20140	COG2912	Transglutaminase-like superfamily
AL543_20145	COG3094	Invasion gene expression up-regulator, SirB
AL543_20150	COG2890	protein-(glutamine-N5) methyltransferase activity
AL543_20155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL543_20160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL543_20165	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL543_20170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL543_20175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL543_20180	COG0193	aminoacyl-tRNA hydrolase activity
AL543_20185	COG0012	GTP binding
AL543_20270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_20280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL543_20295	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL543_20295	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL543_20300	COG1706	bacterial-type flagellum-dependent cell motility
AL543_20305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL543_20310	COG4786	Flagellar basal body rod
AL543_20315	COG4787	bacterial-type flagellum-dependent cell motility
AL543_20320	COG1749	Flagellar hook protein flgE
AL543_20325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL543_20330	COG1558	bacterial-type flagellum-dependent cell motility
AL543_20335	COG1815	bacterial-type flagellum-dependent cell motility
AL543_20350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL543_20355	COG0784	Response regulator, receiver
AL543_20355	COG0835	chemotaxis
AL543_20405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL543_20410	COG2217	Heavy metal translocating P-type atpase
AL543_20410	COG2608	mercury ion transmembrane transporter activity
AL543_20440	COG2840	Smr protein MutS2
AL543_20445	COG1187	pseudouridine synthase activity
AL543_20450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL543_20455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL543_20460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL543_20465	COG0121	glutamine amidotransferase
AL543_20470	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL543_20475	COG1960	acyl-CoA dehydrogenase activity
AL543_20480	COG1294	oxidase, subunit
AL543_20500	COG3220	belongs to the UPF0276 family
AL543_20520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL543_20525	COG0328	RNA-DNA hybrid ribonuclease activity
AL543_20530	COG2226	methyltransferase
AL543_20535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL543_20540	COG1388	LysM domain
AL543_20540	COG0741	lytic transglycosylase activity
AL543_20550	COG0347	Belongs to the P(II) protein family
AL543_20560	COG0037	tRNA processing
AL543_20565	COG0825	malonyl-CoA metabolic process
AL543_20575	COG1063	alcohol dehydrogenase
AL543_20585	COG0582	viral genome integration into host DNA
AL543_20785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_21020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL543_21225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A