locus-tag	class	description
VM_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VM_00010	COG0592	DNA-directed DNA polymerase activity
VM_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VM_00020	COG0187	DNA topoisomerase II activity
VM_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
VM_00040	COG3977	Valine--pyruvate aminotransferase
VM_00045	COG0751	glycine-tRNA ligase activity
VM_00050	COG0752	glycyl-tRNA synthetase alpha subunit
VM_00055	COG2119	membrane
VM_00065	COG0425	Belongs to the sulfur carrier protein TusA family
VM_00080	COG0604	alcohol dehydrogenase
VM_00090	COG0129	dihydroxy-acid dehydratase activity
VM_00095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VM_00110	COG0606	chelatase, subunit chli
VM_00115	COG0204	Acyl-transferase
VM_00120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VM_00125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VM_00135	COG3084	Protein conserved in bacteria
VM_00145	COG4326	sporulation control protein
VM_00150	COG1272	protein, Hemolysin III
VM_00160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VM_00165	COG0569	domain protein
VM_00170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VM_00170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VM_00180	COG0242	peptide deformylase activity
VM_00185	COG1652	LysM domain
VM_00190	COG0758	DNA mediated transformation
VM_00195	COG2922	Belongs to the Smg family
VM_00200	COG0551	DNA topoisomerase type I activity
VM_00205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VM_00210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VM_00215	COG0009	L-threonylcarbamoyladenylate synthase
VM_00225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VM_00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VM_00280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VM_00285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VM_00295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VM_00300	COG2104	thiamine diphosphate biosynthetic process
VM_00305	COG2022	thiamine diphosphate biosynthetic process
VM_00310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VM_00315	COG0006	proline dipeptidase activity
VM_00315	COG0006	proline dipeptidase activity
VM_00325	COG2814	Major facilitator Superfamily
VM_00335	COG1522	sequence-specific DNA binding
VM_00340	COG5001	Diguanylate cyclase
VM_00340	COG5002	protein histidine kinase activity
VM_00345	COG0742	ribosomal rna small subunit methyltransferase
VM_00355	COG0697	spore germination
VM_00360	COG0589	response to stress
VM_00370	COG1528	Iron-storage protein
VM_00380	COG2081	HI0933 family
VM_00385	COG0840	transmembrane signaling receptor activity
VM_00395	COG1322	Protein conserved in bacteria
VM_00400	COG2226	methyltransferase
VM_00410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VM_00415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VM_00420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VM_00425	COG0805	protein transport
VM_00430	COG0534	Mate efflux family protein
VM_00440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VM_00445	COG2937	Belongs to the GPAT DAPAT family
VM_00450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VM_00455	COG3161	chorismate lyase activity
VM_00465	COG1580	Controls the rotational direction of flagella during chemotaxis
VM_00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VM_00485	COG0084	hydrolase, TatD family'
VM_00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VM_00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VM_00510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VM_00525	COG3078	GTPase activator activity
VM_00535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VM_00540	COG3071	HemY protein
VM_00545	COG2959	enzyme of heme biosynthesis
VM_00550	COG1587	Uroporphyrinogen-III synthase
VM_00555	COG0181	hydroxymethylbilane synthase activity
VM_00565	COG3072	Adenylate cyclase
VM_00570	COG1965	Belongs to the frataxin family
VM_00580	COG0019	diaminopimelate decarboxylase activity
VM_00585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VM_00595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VM_00600	COG1011	Hydrolase
VM_00605	COG2199	diguanylate cyclase activity
VM_00605	COG2200	EAL domain
VM_00605	COG3287	FIST C domain
VM_00620	COG0561	phosphatase activity
VM_00625	COG2267	carboxylic ester hydrolase activity
VM_00630	COG1280	lysine exporter protein (LysE YggA)
VM_00635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VM_00640	COG0783	Belongs to the Dps family
VM_00675	COG0742	ribosomal rna small subunit methyltransferase
VM_00680	COG0552	protein localization to endoplasmic reticulum
VM_00685	COG2884	Cell division ATP-binding protein ftsE
VM_00690	COG2177	Part of the ABC transporter FtsEX involved in
VM_00695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VM_00705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VM_00720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VM_00725	COG4206	TonB-dependent receptor
VM_00735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VM_00800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VM_00805	COG3300	MHYT domain
VM_00805	COG5001	Diguanylate cyclase
VM_00815	COG3852	Histidine kinase
VM_00825	COG0174	glutamine synthetase
VM_00850	COG1490	D-aminoacyl-tRNA deacylase activity
VM_00855	COG0456	acetyltransferase
VM_00865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VM_00870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VM_00875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VM_00880	COG3031	protein transport across the cell outer membrane
VM_00890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VM_00895	COG1459	type II secretion system
VM_00900	COG2165	general secretion pathway protein
VM_00905	COG2165	general secretion pathway protein
VM_00910	COG2165	general secretion pathway protein
VM_00915	COG4795	General secretion pathway protein
VM_00920	COG3156	type II secretion system protein K
VM_00925	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VM_00930	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VM_00940	COG1218	3'(2'),5'-bisphosphate nucleotidase
VM_00945	COG0494	nUDIX hydrolase
VM_00950	COG0316	Belongs to the HesB IscA family
VM_00950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VM_00955	COG1040	competence protein
VM_00960	COG0596	Alpha beta hydrolase
VM_00970	COG2183	response to ionizing radiation
VM_01000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VM_01070	COG1061	Type III restriction enzyme res subunit
VM_01080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VM_01115	COG1129	ABC transporter
VM_01120	COG1172	Belongs to the binding-protein-dependent transport system permease family
VM_01125	COG1472	Belongs to the glycosyl hydrolase 3 family
VM_01135	COG0745	RESPONSE REGULATOR receiver
VM_01145	COG2233	PERMEase
VM_01150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VM_01155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VM_01160	COG1758	RNA polymerase activity
VM_01165	COG0194	GDP metabolic process
VM_01170	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VM_01175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VM_01190	COG3423	Transcriptional regulator
VM_01195	COG2801	Transposase and inactivated derivatives
VM_01200	COG2842	Transposition protein
VM_01375	COG4397	Mu-like prophage major head subunit gpT
VM_01385	COG4387	Mu-like prophage protein GP36
VM_01415	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
VM_01435	COG4384	Bacteriophage Mu Gp45 protein
VM_01445	COG3299	homolog of phage Mu protein gp47
VM_01450	COG3778	Protein conserved in bacteria
VM_01465	COG3263	regulation of cellular component size
VM_01475	COG4232	protein-disulfide reductase activity
VM_01480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VM_01485	COG1027	Aspartate ammonia-lyase
VM_01495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VM_01505	COG2205	protein histidine kinase activity
VM_01510	COG0745	RESPONSE REGULATOR receiver
VM_01520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VM_01525	COG0205	6-phosphofructokinase activity
VM_01530	COG1494	fructose-1,6-bisphosphatase
VM_01535	COG3074	FtsZ-dependent cytokinesis
VM_01540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VM_01545	COG0527	aspartate kinase activity
VM_01545	COG0460	homoserine dehydrogenase
VM_01550	COG0626	cystathionine gamma-synthase activity
VM_01555	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VM_01560	COG0281	malic enzyme
VM_01565	COG0254	rRNA binding
VM_01570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VM_01575	COG1609	Transcriptional regulator
VM_01585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VM_01590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VM_01595	COG1575	Belongs to the MenA family. Type 1 subfamily
VM_01600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VM_01610	COG0149	triose-phosphate isomerase activity
VM_01635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VM_01640	COG0459	protein refolding
VM_01650	COG1509	lysine 2,3-aminomutase activity
VM_01655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VM_01660	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VM_01665	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VM_01670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VM_01675	COG1053	succinate dehydrogenase
VM_01680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VM_01685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VM_01690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VM_01695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VM_01700	COG1045	serine acetyltransferase
VM_01710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VM_01715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VM_01720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VM_01725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VM_01730	COG0137	argininosuccinate synthase activity
VM_01735	COG0165	Argininosuccinate lyase
VM_01750	COG0678	peroxiredoxin activity
VM_01750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VM_01760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VM_01790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VM_01795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VM_01805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VM_01810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VM_01815	COG0546	phosphoglycolate phosphatase activity
VM_01820	COG0180	Tryptophanyl-tRNA synthetase
VM_01835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VM_01840	COG0446	pyridine nucleotide-disulphide oxidoreductase
VM_01850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VM_01860	COG1012	belongs to the aldehyde dehydrogenase family
VM_01870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VM_01875	COG3954	Phosphoribulokinase
VM_01885	COG0429	hydrolase of the alpha beta-hydrolase fold
VM_01895	COG0488	(ABC) transporter
VM_01900	COG2249	NAD(P)H dehydrogenase (quinone) activity
VM_01915	COG1047	Peptidyl-prolyl cis-trans
VM_01925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VM_01930	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VM_01935	COG3083	sulfuric ester hydrolase activity
VM_01940	COG0557	exoribonuclease II activity
VM_01945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VM_01950	COG0051	transcription antitermination factor activity, RNA binding
VM_01955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VM_01960	COG0088	Forms part of the polypeptide exit tunnel
VM_01965	COG0089	rRNA binding
VM_01970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VM_01975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VM_01980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VM_01985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VM_01990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VM_01995	COG0255	Belongs to the universal ribosomal protein uL29 family
VM_02005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VM_02010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VM_02015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VM_02020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VM_02025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VM_02030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VM_02035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VM_02040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VM_02045	COG1841	ribosomal large subunit assembly
VM_02050	COG0200	Binds to the 23S rRNA
VM_02055	COG0201	protein transport
VM_02065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VM_02070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VM_02075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VM_02080	COG0202	RNA polymerase activity
VM_02085	COG0203	ribosomal protein L17
VM_02095	COG0545	Peptidyl-prolyl cis-trans isomerase
VM_02100	COG3061	Opacity-associated protein A
VM_02100	COG3266	domain, Protein
VM_02105	COG0697	spore germination
VM_02110	COG2153	protein acetylation
VM_02115	COG0513	Belongs to the DEAD box helicase family
VM_02130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VM_02130	COG1648	precorrin-2 dehydrogenase activity
VM_02135	COG0175	sulfate reduction
VM_02140	COG2895	sulfate adenylyltransferase (ATP) activity
VM_02145	COG0529	Catalyzes the synthesis of activated sulfate
VM_02165	COG1136	(ABC) transporter
VM_02180	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VM_02185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VM_02190	COG0729	surface antigen
VM_02195	COG2911	Protein conserved in bacteria
VM_02200	COG2105	PFAM AIG2 family protein
VM_02210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VM_02215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VM_02225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VM_02230	COG0163	prenyltransferase activity
VM_02240	COG4143	(ABC) transporter
VM_02245	COG1178	ABC-type Fe3 transport system permease component
VM_02250	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VM_02255	COG3028	Belongs to the UPF0307 family
VM_02260	COG0312	modulator of DNA gyrase
VM_02265	COG2239	Acts as a magnesium transporter
VM_02270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_02280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_02285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VM_02295	COG1137	ATPase activity
VM_02300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VM_02315	COG0517	IMP dehydrogenase activity
VM_02315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VM_02330	COG1127	ABC transporter
VM_02335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VM_02340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VM_02345	COG2854	intermembrane phospholipid transfer
VM_02355	COG5007	Belongs to the BolA IbaG family
VM_02360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VM_02365	COG0204	Acyl-transferase
VM_02370	COG0251	oxidation-reduction process
VM_02375	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VM_02380	COG0540	Belongs to the ATCase OTCase family
VM_02385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VM_02390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VM_02400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VM_02405	COG0564	pseudouridine synthase activity
VM_02410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VM_02415	COG4269	membrane
VM_02425	COG0525	valine-tRNA ligase activity
VM_02430	COG2927	DNA polymerase III (CHI subunit)
VM_02435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VM_02440	COG0795	lipopolysaccharide-transporting ATPase activity
VM_02445	COG0795	lipopolysaccharide-transporting ATPase activity
VM_02460	COG3437	response regulator, receiver
VM_02500	COG0066	3-isopropylmalate dehydratase activity
VM_02505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VM_02510	COG0473	3-isopropylmalate dehydrogenase activity
VM_02515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VM_02525	COG0671	phosphoesterase, PA-phosphatase related
VM_02535	COG0583	DNA-binding transcription factor activity
VM_02540	COG1022	Amp-dependent synthetase and ligase
VM_02545	COG0028	Belongs to the TPP enzyme family
VM_02550	COG0440	acetolactate synthase activity
VM_02555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VM_02560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VM_02565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VM_02575	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VM_02580	COG3079	Belongs to the UPF0149 family
VM_02585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VM_02590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VM_02600	COG0354	folic acid binding
VM_02605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VM_02615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VM_02625	COG1595	DNA-templated transcription, initiation
VM_02640	COG3086	response to oxidative stress
VM_02645	COG0481	GTPase activity
VM_02650	COG0681	Belongs to the peptidase S26 family
VM_02655	COG0571	ribonuclease III activity
VM_02660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VM_02665	COG1381	Involved in DNA repair and RecF pathway recombination
VM_02670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VM_02675	COG0736	holo-[acyl-carrier-protein] synthase activity
VM_02695	COG3850	Histidine kinase
VM_02695	COG2205	protein histidine kinase activity
VM_02695	COG3437	response regulator, receiver
VM_02695	COG4999	Histidine kinase
VM_02700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VM_02705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VM_02710	COG3956	TIGRFAM MazG family protein
VM_02720	COG0504	CTP synthase activity
VM_02725	COG0148	phosphopyruvate hydratase activity
VM_02735	COG0814	amino acid
VM_02745	COG0617	tRNA 3'-terminal CCA addition
VM_02750	COG3409	Peptidoglycan-binding domain 1 protein
VM_02750	COG3267	Type II secretory pathway component ExeA
VM_02760	COG4991	sh3 domain protein
VM_02765	COG0306	phosphate transporter
VM_02770	COG1392	Phosphate transport regulator
VM_02775	COG3025	triphosphatase activity
VM_02780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VM_02790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VM_02800	COG1538	Outer membrane efflux protein
VM_02805	COG0494	nUDIX hydrolase
VM_02810	COG3151	Protein conserved in bacteria
VM_02820	COG3150	esterase
VM_02825	COG0187	DNA topoisomerase II activity
VM_02830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VM_02835	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VM_02840	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VM_02845	COG0237	dephospho-CoA kinase activity
VM_02855	COG1459	type II secretion system
VM_02860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VM_02880	COG0716	FMN binding
VM_02885	COG4974	Belongs to the 'phage' integrase family
VM_02890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VM_02895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VM_02900	COG1227	inorganic diphosphatase activity
VM_02905	COG0737	Belongs to the 5'-nucleotidase family
VM_02910	COG2186	Transcriptional regulator
VM_02915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VM_02920	COG0508	dehydrogenase complex catalyzes the overall conversion of
VM_02925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VM_02935	COG0275	rRNA processing
VM_02940	COG3116	cell division
VM_02945	COG0768	penicillin binding
VM_02950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VM_02955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VM_02960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VM_02965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VM_02970	COG0772	Belongs to the SEDS family
VM_02975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VM_02980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VM_02985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VM_02990	COG0849	cell division
VM_02995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VM_03000	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VM_03010	COG0653	protein targeting
VM_03015	COG0494	nUDIX hydrolase
VM_03020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VM_03025	COG0505	Belongs to the CarA family
VM_03030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VM_03035	COG0730	response to heat
VM_03040	COG0583	DNA-binding transcription factor activity
VM_03045	COG2860	membrane
VM_03050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VM_03060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VM_03070	COG0493	'glutamate synthase
VM_03075	COG0067	glutamate synthase
VM_03075	COG0069	glutamate synthase activity
VM_03075	COG0070	glutamate synthase
VM_03085	COG0069	glutamate synthase activity
VM_03085	COG0067	glutamate synthase
VM_03085	COG0070	glutamate synthase
VM_03090	COG1242	4 iron, 4 sulfur cluster binding
VM_03095	COG2203	Gaf domain
VM_03095	COG4251	negative regulation of phosphorylation
VM_03095	COG5001	Diguanylate cyclase
VM_03095	COG3706	GGDEF domain
VM_03100	COG5002	protein histidine kinase activity
VM_03100	COG2198	Histidine kinase
VM_03100	COG0784	Response regulator, receiver
VM_03105	COG0745	RESPONSE REGULATOR receiver
VM_03115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VM_03130	COG0083	homoserine kinase activity
VM_03135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VM_03140	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VM_03145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VM_03150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VM_03160	COG2801	Transposase and inactivated derivatives
VM_03170	COG1115	amino acid carrier protein
VM_03180	COG0084	hydrolase, TatD family'
VM_03185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VM_03195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VM_03200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VM_03205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VM_03210	COG0813	purine-nucleoside phosphorylase activity
VM_03220	COG0560	Phosphoserine phosphatase
VM_03230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VM_03235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VM_03240	COG0583	DNA-binding transcription factor activity
VM_03250	COG1022	Amp-dependent synthetase and ligase
VM_03265	COG3250	beta-galactosidase activity
VM_03270	COG1609	Transcriptional regulator
VM_03275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VM_03290	COG0189	ligase activity
VM_03290	COG0569	domain protein
VM_03305	COG2171	N-acyltransferase activity
VM_03315	COG3141	response to X-ray
VM_03330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VM_03335	COG1074	ATP-dependent DNA helicase activity
VM_03340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VM_03355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VM_03355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VM_03365	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VM_03370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VM_03375	COG2166	iron-sulfur cluster assembly
VM_03380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VM_03385	COG0693	protein deglycase activity
VM_03390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VM_03405	COG1595	DNA-templated transcription, initiation
VM_03415	COG2211	Major facilitator Superfamily
VM_03420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VM_03430	COG2813	Specifically methylates the guanine in position
VM_03435	COG0271	Belongs to the BolA IbaG family
VM_03440	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VM_03445	COG1805	sodium ion transport
VM_03450	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VM_03455	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VM_03460	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VM_03465	COG2871	sodium ion transport
VM_03475	COG1477	protein flavinylation
VM_03485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VM_03500	COG0733	neurotransmitter:sodium symporter activity
VM_03510	COG0189	ligase activity
VM_03515	COG4067	protein conserved in archaea
VM_03515	COG0189	ligase activity
VM_03520	COG2195	Cleaves the N-terminal amino acid of tripeptides
VM_03525	COG2252	PERMEase
VM_03530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VM_03545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VM_03550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VM_03555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VM_03560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VM_03560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VM_03575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VM_03580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VM_03585	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VM_03590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VM_03600	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VM_03605	COG0024	Methionine aminopeptidase
VM_03610	COG0052	Belongs to the universal ribosomal protein uS2 family
VM_03615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VM_03620	COG0528	UMP kinase activity
VM_03625	COG0233	cytoplasmic translational termination
VM_03630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VM_03635	COG0575	Belongs to the CDS family
VM_03640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VM_03645	COG0750	zinc metalloprotease
VM_03655	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VM_03660	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VM_03665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VM_03670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VM_03675	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VM_03680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VM_03685	COG0587	DNA-directed DNA polymerase activity
VM_03690	COG0825	malonyl-CoA metabolic process
VM_03695	COG0037	tRNA processing
VM_03705	COG0347	Belongs to the P(II) protein family
VM_03715	COG1388	LysM domain
VM_03715	COG0741	lytic transglycosylase activity
VM_03720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VM_03725	COG2226	methyltransferase
VM_03730	COG0328	RNA-DNA hybrid ribonuclease activity
VM_03735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VM_03745	COG1960	acyl-CoA dehydrogenase activity
VM_03750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VM_03755	COG0121	glutamine amidotransferase
VM_03760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VM_03765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VM_03770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VM_03775	COG1187	pseudouridine synthase activity
VM_03780	COG2840	Smr protein MutS2
VM_03810	COG2608	mercury ion transmembrane transporter activity
VM_03810	COG2217	Heavy metal translocating P-type atpase
VM_03815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VM_03865	COG0835	chemotaxis
VM_03865	COG0784	Response regulator, receiver
VM_03870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VM_03875	COG1815	bacterial-type flagellum-dependent cell motility
VM_03880	COG1558	bacterial-type flagellum-dependent cell motility
VM_03885	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VM_03890	COG1749	Flagellar hook protein flgE
VM_03895	COG4787	bacterial-type flagellum-dependent cell motility
VM_03900	COG4786	Flagellar basal body rod
VM_03905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VM_03910	COG1706	bacterial-type flagellum-dependent cell motility
VM_03915	COG1705	Flagellar rod assembly protein muramidase FlgJ
VM_03915	COG3951	Flagellar rod assembly protein muramidase FlgJ
VM_03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VM_03935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VM_04020	COG0012	GTP binding
VM_04025	COG0193	aminoacyl-tRNA hydrolase activity
VM_04030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VM_04035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VM_04040	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VM_04045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VM_04050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VM_04055	COG2890	protein-(glutamine-N5) methyltransferase activity
VM_04060	COG3094	Invasion gene expression up-regulator, SirB
VM_04065	COG2912	Transglutaminase-like superfamily
VM_04070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VM_04075	COG0737	Belongs to the 5'-nucleotidase family
VM_04080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VM_04085	COG2233	PERMEase
VM_04105	COG1393	Belongs to the ArsC family
VM_04110	COG4783	chaperone-mediated protein folding
VM_04150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VM_04185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VM_04190	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VM_04200	COG1876	peptidase activity
VM_04205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VM_04210	COG1393	Belongs to the ArsC family
VM_04230	COG2837	iron assimilation
VM_04235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VM_04240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VM_04245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VM_04250	COG1334	flagellar protein FlaG
VM_04255	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VM_04265	COG1516	flagellar protein fliS
VM_04270	COG2204	response regulator
VM_04275	COG4191	Histidine kinase
VM_04280	COG2204	response regulator
VM_04295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VM_04300	COG1317	bacterial-type flagellum organization
VM_04345	COG1987	bacterial-type flagellum assembly
VM_04365	COG2890	protein-(glutamine-N5) methyltransferase activity
VM_04375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VM_04380	COG2860	membrane
VM_04385	COG3101	peptidyl-lysine hydroxylation
VM_04395	COG0431	NADPH-dependent FMN reductase
VM_04400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VM_04400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VM_04405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VM_04410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VM_04415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VM_04425	COG0735	belongs to the Fur family
VM_04435	COG0583	DNA-binding transcription factor activity
VM_04445	COG1346	cytolysis
VM_04460	COG0596	Alpha beta hydrolase
VM_04465	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VM_04470	COG0033	Phosphoglucomutase
VM_04480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VM_04485	COG0372	Belongs to the citrate synthase family
VM_04490	COG2009	succinate dehydrogenase
VM_04495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VM_04500	COG1053	succinate dehydrogenase
VM_04510	COG0567	Dehydrogenase, E1 component
VM_04515	COG0508	dehydrogenase complex catalyzes the overall conversion of
VM_04520	COG0045	succinate-CoA ligase (ADP-forming) activity
VM_04530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VM_04535	COG1121	(ABC) transporter
VM_04540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VM_04545	COG4977	sequence-specific DNA binding
VM_04550	COG1918	ferrous iron import across plasma membrane
VM_04575	COG0018	arginyl-trna synthetase
VM_04585	COG1025	Belongs to the peptidase M16 family
VM_04590	COG2062	phosphohistidine phosphatase, SixA
VM_04605	COG0455	bacterial-type flagellum organization
VM_04620	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VM_04625	COG2198	Histidine kinase
VM_04625	COG0643	Histidine kinase
VM_04630	COG2201	protein-glutamate methylesterase activity
VM_04635	COG1192	Involved in chromosome partitioning
VM_04645	COG0835	chemotaxis
VM_04655	COG4133	protoheme IX ABC transporter activity
VM_04660	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VM_04665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VM_04675	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VM_04680	COG1138	Cytochrome C-type biogenesis protein
VM_04685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VM_04690	COG3088	subunit of a heme lyase
VM_04690	COG4235	cytochrome complex assembly
VM_04700	COG2853	Lipoprotein
VM_04720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VM_04725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VM_04730	COG0123	including yeast histone deacetylase and acetoin utilization protein
VM_04745	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
VM_04765	COG3083	sulfuric ester hydrolase activity
VM_04775	COG3081	Nucleoid-associated protein
VM_04785	COG1757	Na H antiporter
VM_04790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VM_04795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VM_04800	COG2095	MarC family integral membrane protein
VM_04805	COG1454	alcohol dehydrogenase
VM_04805	COG1012	belongs to the aldehyde dehydrogenase family
VM_04815	COG0659	secondary active sulfate transmembrane transporter activity
VM_04820	COG1530	ribonuclease E activity
VM_04830	COG0564	pseudouridine synthase activity
VM_04835	COG0424	maF-like protein
VM_04840	COG1399	metal-binding, possibly nucleic acid-binding protein
VM_04845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VM_04850	COG0416	fatty acid biosynthetic process
VM_04855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VM_04865	COG1028	Short-chain dehydrogenase reductase Sdr
VM_04870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VM_04875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VM_04880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VM_04885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VM_04890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VM_04895	COG0470	DNA polymerase III
VM_04900	COG0084	hydrolase, TatD family'
VM_04905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VM_04905	COG1263	PTS System
VM_04915	COG0733	neurotransmitter:sodium symporter activity
VM_04925	COG4667	esterase of the alpha-beta hydrolase superfamily
VM_04935	COG1940	carbohydrate kinase activity
VM_04940	COG0835	chemotaxis
VM_04940	COG0784	Response regulator, receiver
VM_04970	COG2226	methyltransferase
VM_04985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VM_04990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VM_05000	COG3139	Protein of unknown function (DUF1315)
VM_05005	COG0252	asparaginase activity
VM_05010	COG0616	signal peptide processing
VM_05015	COG0446	pyridine nucleotide-disulphide oxidoreductase
VM_05015	COG1902	pentaerythritol trinitrate reductase activity
VM_05020	COG0788	formyltetrahydrofolate deformylase activity
VM_05030	COG1199	ATP-dependent helicase activity
VM_05035	COG1214	PFAM Peptidase M22, glycoprotease
VM_05050	COG0596	Alpha beta hydrolase
VM_05055	COG0318	PFAM AMP-dependent synthetase and ligase
VM_05060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VM_05070	COG0705	Rhomboid family
VM_05080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VM_05085	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VM_05090	COG0436	Aminotransferase
VM_05095	COG1169	isochorismate synthase
VM_05100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VM_05105	COG0596	Alpha beta hydrolase
VM_05115	COG1441	menaquinone biosynthetic process
VM_05125	COG3135	benzoate transporter
VM_05130	COG1396	sequence-specific DNA binding
VM_05140	COG0477	Major facilitator Superfamily
VM_05160	COG3015	lipoprotein NlpE involved in copper resistance
VM_05165	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VM_05170	COG2894	cell division
VM_05175	COG0850	regulation of cytokinetic process
VM_05180	COG3100	YcgL domain-containing protein
VM_05185	COG2951	lytic endotransglycosylase activity
VM_05195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VM_05200	COG3469	chitinase activity
VM_05200	COG3325	Belongs to the glycosyl hydrolase 18 family
VM_05210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VM_05230	COG0671	phosphoesterase, PA-phosphatase related
VM_05250	COG4589	Belongs to the CDS family
VM_05260	COG5001	Diguanylate cyclase
VM_05260	COG3300	MHYT domain
VM_05275	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VM_05280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VM_05285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VM_05290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VM_05300	COG4191	Histidine kinase
VM_05310	COG0544	peptidyl-prolyl cis-trans isomerase activity
VM_05320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VM_05325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VM_05330	COG0776	regulation of translation
VM_05335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VM_05340	COG1555	photosystem II stabilization
VM_05345	COG1943	Transposase
VM_05350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VM_05355	COG0539	negative regulation of cytoplasmic translation
VM_05360	COG0776	regulation of translation
VM_05365	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VM_05370	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VM_05375	COG0284	orotidine-5'-phosphate decarboxylase activity
VM_05390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VM_05395	COG1215	transferase activity, transferring glycosyl groups
VM_05400	COG0438	transferase activity, transferring glycosyl groups
VM_05435	COG0438	transferase activity, transferring glycosyl groups
VM_05445	COG2204	response regulator
VM_05490	COG0601	transmembrane transport
VM_05495	COG4239	(ABC) transporter, permease
VM_05500	COG4166	transmembrane transport
VM_05505	COG0444	Belongs to the ABC transporter superfamily
VM_05535	COG0583	DNA-binding transcription factor activity
VM_05545	COG0686	Belongs to the AlaDH PNT family
VM_05550	COG1522	sequence-specific DNA binding
VM_05555	COG1674	ftsk spoiiie
VM_05560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VM_05565	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VM_05570	COG2186	Transcriptional regulator
VM_05585	COG0537	adenosine 5'-monophosphoramidase activity
VM_05615	COG1252	NADH dehydrogenase
VM_05630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VM_05640	COG4591	ABC-type transport system involved in lipoprotein release permease component
VM_05645	COG1136	(ABC) transporter
VM_05650	COG4591	ABC-type transport system involved in lipoprotein release permease component
VM_05660	COG0658	competence protein
VM_05660	COG2333	competence protein COMEC
VM_05665	COG1132	(ABC) transporter
VM_05670	COG1663	tetraacyldisaccharide 4'-kinase activity
VM_05680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VM_05695	COG0745	RESPONSE REGULATOR receiver
VM_05705	COG2719	SpoVR family
VM_05710	COG2718	Belongs to the UPF0229 family
VM_05715	COG2766	serine protein kinase
VM_05720	COG3013	Belongs to the UPF0304 family
VM_05730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VM_05735	COG0840	transmembrane signaling receptor activity
VM_05745	COG1882	Formate acetyltransferase
VM_05765	COG4215	(ABC) transporter
VM_05770	COG4160	amino acid transport
VM_05775	COG0708	Exodeoxyribonuclease III
VM_05780	COG0840	transmembrane signaling receptor activity
VM_05790	COG3923	Primosomal replication protein n
VM_05795	COG0730	response to heat
VM_05800	COG1199	ATP-dependent helicase activity
VM_05815	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VM_05820	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VM_05825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VM_05830	COG0215	cysteine-tRNA ligase activity
VM_05835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VM_05840	COG0632	four-way junction helicase activity
VM_05845	COG2255	four-way junction helicase activity
VM_05850	COG1271	oxidase subunit
VM_05855	COG1294	oxidase, subunit
VM_05860	COG4890	Cyd operon protein YbgT
VM_05870	COG0824	Thioesterase
VM_05875	COG0811	peptide transport
VM_05890	COG0823	Involved in the tonB-independent uptake of proteins
VM_05895	COG2885	chlorophyll binding
VM_05905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VM_05915	COG5002	protein histidine kinase activity
VM_05915	COG0784	Response regulator, receiver
VM_05930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_05930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_05930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_05935	COG2207	Transcriptional regulator
VM_05945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_05950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_05955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VM_05965	COG3537	Alpha-1,2-mannosidase
VM_05970	COG3537	Alpha-1,2-mannosidase
VM_05980	COG3537	Alpha-1,2-mannosidase
VM_05985	COG3537	Alpha-1,2-mannosidase
VM_05990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_06010	COG2801	Transposase and inactivated derivatives
VM_06055	COG1475	DNA binding
VM_06060	COG3969	phosphoadenosine phosphosulfate
VM_06065	COG4932	domain protein
VM_06065	COG5492	domain, Protein
VM_06090	COG0583	DNA-binding transcription factor activity
VM_06195	COG3250	beta-galactosidase activity
VM_06210	COG3069	C4-dicarboxylate transmembrane transporter activity
VM_06215	COG2195	Cleaves the N-terminal amino acid of tripeptides
VM_06225	COG2200	EAL domain
VM_06225	COG2771	luxR family
VM_06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VM_06240	COG1309	transcriptional regulator
VM_06245	COG1012	belongs to the aldehyde dehydrogenase family
VM_06265	COG1960	acyl-CoA dehydrogenase activity
VM_06270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VM_06275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VM_06280	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VM_06285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VM_06295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VM_06305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VM_06315	COG0297	glycogen (starch) synthase activity
VM_06340	COG1609	Transcriptional regulator
VM_06345	COG3381	protein complex oligomerization
VM_06350	COG0745	RESPONSE REGULATOR receiver
VM_06360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VM_06365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VM_06370	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VM_06375	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VM_06380	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VM_06395	COG1032	radical SAM domain protein
VM_06400	COG2203	Gaf domain
VM_06400	COG2200	EAL domain
VM_06400	COG2199	diguanylate cyclase activity
VM_06405	COG0612	Peptidase, M16
VM_06420	COG0583	DNA-binding transcription factor activity
VM_06425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VM_06435	COG2350	Protein conserved in bacteria
VM_06440	COG1607	acyl-coa hydrolase
VM_06445	COG2917	probably involved in intracellular septation
VM_06460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VM_06465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VM_06475	COG2116	formate transmembrane transporter activity
VM_06485	COG4459	periplasmic nitrate reductase
VM_06490	COG3005	denitrification pathway
VM_06495	COG0243	molybdopterin cofactor binding
VM_06500	COG2801	Transposase and inactivated derivatives
VM_06510	COG1162	GTPase activity
VM_06520	COG1227	inorganic diphosphatase activity
VM_06535	COG4172	Belongs to the ABC transporter superfamily
VM_06545	COG4171	peptide transport system, permease
VM_06550	COG4168	peptide transport system, permease
VM_06560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VM_06565	COG1842	Phage shock protein A
VM_06580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VM_06585	COG0519	Catalyzes the synthesis of GMP from XMP
VM_06600	COG0733	neurotransmitter:sodium symporter activity
VM_06605	COG0564	pseudouridine synthase activity
VM_06610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VM_06615	COG4136	ATPase activity
VM_06620	COG4135	transport system, permease component
VM_06625	COG4134	Bacterial extracellular solute-binding protein
VM_06635	COG3313	Fe-S protein
VM_06645	COG0842	Transport permease protein
VM_06650	COG1131	(ABC) transporter
VM_06655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VM_06660	COG0814	amino acid
VM_06670	COG2239	Acts as a magnesium transporter
VM_06675	COG2205	protein histidine kinase activity
VM_06675	COG0784	Response regulator, receiver
VM_06690	COG4934	collagen metabolic process
VM_06710	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
VM_06740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VM_06755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VM_06765	COG0745	RESPONSE REGULATOR receiver
VM_06775	COG1061	Type III restriction enzyme res subunit
VM_06780	COG1187	pseudouridine synthase activity
VM_06795	COG0702	epimerase
VM_06800	COG0534	Mate efflux family protein
VM_06805	COG4181	ATPase activity
VM_06820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VM_06825	COG1943	Transposase
VM_06835	COG1748	Saccharopine dehydrogenase
VM_06840	COG0019	diaminopimelate decarboxylase activity
VM_06850	COG1538	Outer membrane efflux protein
VM_06875	COG0583	DNA-binding transcription factor activity
VM_06885	COG1451	nucleotide metabolic process
VM_06900	COG3063	Type IV pilus biogenesis stability protein PilW
VM_06905	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VM_06925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VM_06940	COG3290	protein histidine kinase activity
VM_06945	COG4565	transcriptional regulatory protein
VM_06955	COG0784	Response regulator, receiver
VM_06955	COG0835	chemotaxis
VM_06970	COG0745	RESPONSE REGULATOR receiver
VM_06970	COG3706	GGDEF domain
VM_06990	COG1085	galactose-1-phosphate uridylyltransferase
VM_06995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VM_07000	COG2017	converts alpha-aldose to the beta-anomer
VM_07010	COG3064	Membrane
VM_07015	COG3059	membrane
VM_07020	COG0753	catalase activity
VM_07065	COG0316	Belongs to the HesB IscA family
VM_07070	COG0719	Fe-S assembly protein
VM_07075	COG0396	ATPase activity
VM_07080	COG0719	Fe-S assembly protein
VM_07085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VM_07100	COG1780	Probably involved in ribonucleotide reductase function
VM_07105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VM_07115	COG0577	efflux transmembrane transporter activity
VM_07115	COG1136	(ABC) transporter
VM_07120	COG0577	efflux transmembrane transporter activity
VM_07120	COG1136	(ABC) transporter
VM_07125	COG0577	efflux transmembrane transporter activity
VM_07150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VM_07155	COG2723	6-phospho-beta-galactosidase activity
VM_07160	COG1609	Transcriptional regulator
VM_07165	COG0251	oxidation-reduction process
VM_07170	COG2731	YhcH YjgK YiaL family protein
VM_07175	COG0584	glycerophosphoryl diester phosphodiesterase
VM_07185	COG3842	ATPase activity
VM_07190	COG0395	ABC-type sugar transport system, permease component
VM_07195	COG1175	transmembrane transport
VM_07215	COG0811	peptide transport
VM_07220	COG0811	peptide transport
VM_07225	COG0848	biopolymer transport protein
VM_07240	COG1793	dna ligase
VM_07250	COG0534	Mate efflux family protein
VM_07270	COG0791	NLP P60 protein
VM_07275	COG0840	transmembrane signaling receptor activity
VM_07290	COG1940	carbohydrate kinase activity
VM_07305	COG0746	molybdenum cofactor guanylyltransferase activity
VM_07310	COG3842	ATPase activity
VM_07315	COG4662	Binding-protein-dependent transport system inner membrane component
VM_07330	COG3852	Histidine kinase
VM_07335	COG0488	(ABC) transporter
VM_07345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VM_07375	COG0243	molybdopterin cofactor binding
VM_07375	COG3383	formate dehydrogenase (NAD+) activity
VM_07380	COG0437	4 iron, 4 sulfur cluster binding
VM_07395	COG0004	ammonium transporteR
VM_07400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VM_07410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VM_07425	COG2996	Protein conserved in bacteria
VM_07430	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VM_07430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VM_07435	COG3008	intermembrane lipid transfer
VM_07440	COG2995	paraquat-inducible protein a
VM_07445	COG1132	(ABC) transporter
VM_07450	COG1956	GAF domain-containing protein
VM_07455	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VM_07470	COG0308	aminopeptidase N
VM_07485	COG0167	dihydroorotate dehydrogenase activity
VM_07495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VM_07495	COG0116	Belongs to the methyltransferase superfamily
VM_07520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VM_07525	COG1067	ATP-dependent peptidase activity
VM_07530	COG3120	sequence-specific DNA binding
VM_07545	COG0784	Response regulator, receiver
VM_07545	COG5002	protein histidine kinase activity
VM_07560	COG3278	Belongs to the heme-copper respiratory oxidase family
VM_07575	COG2010	Cytochrome c
VM_07585	COG2217	Heavy metal translocating P-type atpase
VM_07600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VM_07605	COG0589	response to stress
VM_07610	COG0037	tRNA processing
VM_07630	COG3842	ATPase activity
VM_07635	COG1176	ABC-type spermidine putrescine transport system, permease component I
VM_07640	COG1177	transmembrane transport
VM_07645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VM_07650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VM_07655	COG1012	belongs to the aldehyde dehydrogenase family
VM_07670	COG2205	protein histidine kinase activity
VM_07670	COG2202	Pas domain
VM_07675	COG2199	diguanylate cyclase activity
VM_07690	COG1115	amino acid carrier protein
VM_07695	COG1280	lysine exporter protein (LysE YggA)
VM_07715	COG3501	Rhs element vgr protein
VM_07725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VM_07730	COG1960	acyl-CoA dehydrogenase activity
VM_07745	COG3384	dioxygenase
VM_07760	COG1012	belongs to the aldehyde dehydrogenase family
VM_07780	COG3971	2-oxopent-4-enoate hydratase activity
VM_07800	COG1846	Transcriptional regulator
VM_07840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VM_07860	COG0513	Belongs to the DEAD box helicase family
VM_07875	COG2076	Multidrug Resistance protein
VM_07880	COG0477	Major facilitator Superfamily
VM_07885	COG0583	DNA-binding transcription factor activity
VM_07890	COG0443	Heat shock 70 kDa protein
VM_07895	COG0402	S-adenosylhomocysteine deaminase activity
VM_07910	COG3766	membrane
VM_07920	COG0754	glutathionylspermidine amidase activity
VM_07930	COG1643	Atp-dependent helicase
VM_07960	COG5001	Diguanylate cyclase
VM_07960	COG3300	MHYT domain
VM_07975	COG0443	Heat shock 70 kDa protein
VM_07980	COG3706	GGDEF domain
VM_08010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VM_08015	COG0602	queuosine metabolic process
VM_08020	COG0561	phosphatase activity
VM_08030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VM_08035	COG4597	amino acid ABC transporter
VM_08040	COG0765	amino acid transport
VM_08045	COG1126	abc transporter atp-binding protein
VM_08050	COG0670	Belongs to the BI1 family
VM_08055	COG2920	part of a sulfur-relay system
VM_08060	COG1254	Belongs to the acylphosphatase family
VM_08070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VM_08075	COG3706	GGDEF domain
VM_08090	COG3437	response regulator, receiver
VM_08095	COG0625	glutathione transferase activity
VM_08105	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VM_08115	COG2195	Cleaves the N-terminal amino acid of tripeptides
VM_08145	COG0372	Belongs to the citrate synthase family
VM_08150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VM_08160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VM_08180	COG0745	RESPONSE REGULATOR receiver
VM_08180	COG3706	GGDEF domain
VM_08190	COG1129	ABC transporter
VM_08220	COG0745	RESPONSE REGULATOR receiver
VM_08225	COG5002	protein histidine kinase activity
VM_08230	COG3713	MltA-interacting MipA family protein
VM_08245	COG4191	Histidine kinase
VM_08245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VM_08250	COG0471	metal ion transport
VM_08255	COG0840	transmembrane signaling receptor activity
VM_08260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VM_08285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VM_08290	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VM_08295	COG3768	UPF0283 membrane protein
VM_08300	COG3106	COG3106 Predicted ATPase
VM_08315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VM_08320	COG0494	nUDIX hydrolase
VM_08325	COG0814	amino acid
VM_08330	COG1760	l-serine dehydratase
VM_08335	COG0720	synthase
VM_08345	COG0017	Asparaginyl-tRNA synthetase
VM_08350	COG0351	phosphomethylpyrimidine kinase
VM_08355	COG0110	maltose O-acetyltransferase activity
VM_08360	COG3437	response regulator, receiver
VM_08360	COG2770	Histidine kinase
VM_08365	COG1448	Aminotransferase
VM_08380	COG0840	transmembrane signaling receptor activity
VM_08385	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VM_08390	COG2943	transferase activity, transferring hexosyl groups
VM_08400	COG3394	polysaccharide catabolic process
VM_08405	COG1486	melibiose metabolic process
VM_08410	COG1447	Phosphotransferase system cellobiose-specific component IIA
VM_08420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VM_08425	COG0726	polysaccharide deacetylase
VM_08430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VM_08435	COG1846	Transcriptional regulator
VM_08460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VM_08475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VM_08480	COG3108	Peptidase M15
VM_08515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VM_08525	COG2814	Major facilitator Superfamily
VM_08540	COG1278	Cold shock
VM_08550	COG4235	cytochrome complex assembly
VM_08550	COG3088	subunit of a heme lyase
VM_08560	COG1138	Cytochrome C-type biogenesis protein
VM_08565	COG3301	Polysulphide reductase, NrfD
VM_08570	COG0437	4 iron, 4 sulfur cluster binding
VM_08575	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VM_08595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VM_08600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VM_08650	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VM_08655	COG4139	cobalamin transport
VM_08660	COG2988	succinylglutamate desuccinylase activity
VM_08675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VM_08680	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VM_08685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VM_08695	COG2925	Exonuclease
VM_08705	COG1346	cytolysis
VM_08710	COG0295	cytidine deaminase activity
VM_08720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VM_08725	COG0500	methyltransferase
VM_08740	COG0776	regulation of translation
VM_08745	COG0072	phenylalanine-tRNA ligase activity
VM_08745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VM_08750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VM_08755	COG0456	acetyltransferase
VM_08790	COG0322	excinuclease ABC activity
VM_08795	COG2197	response regulator
VM_08800	COG0417	DNA replication proofreading
VM_08805	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VM_08815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VM_08835	COG1228	amidohydrolase
VM_08840	COG0010	Belongs to the arginase family
VM_08845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VM_08850	COG2986	histidine ammonia-lyase
VM_08870	COG0247	lactate metabolic process
VM_08870	COG0277	FAD linked oxidase domain protein
VM_08885	COG2885	chlorophyll binding
VM_08905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VM_08915	COG0281	malic enzyme
VM_08925	COG2949	membrane
VM_08930	COG3706	GGDEF domain
VM_08945	COG0492	ferredoxin-NADP+ reductase activity
VM_08950	COG4988	ABC transporter
VM_08955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VM_08960	COG1187	pseudouridine synthase activity
VM_08965	COG0009	L-threonylcarbamoyladenylate synthase
VM_08970	COG0613	PHP domain protein
VM_08980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VM_08985	COG0512	Glutamine amidotransferase of anthranilate synthase
VM_08990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VM_08995	COG0134	indole-3-glycerol-phosphate synthase activity
VM_08995	COG0135	phosphoribosylanthranilate isomerase activity
VM_09000	COG0133	tryptophan synthase activity
VM_09005	COG0159	tryptophan synthase activity
VM_09015	COG1943	Transposase
VM_09020	COG1435	thymidine kinase activity
VM_09025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VM_09030	COG1801	Protein of unknown function DUF72
VM_09035	COG4106	trans-aconitate 2-methyltransferase activity
VM_09040	COG0500	methyltransferase
VM_09045	COG0189	ligase activity
VM_09045	COG4067	protein conserved in archaea
VM_09060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VM_09070	COG3852	Histidine kinase
VM_09090	COG3070	regulator of competence-specific genes
VM_09100	COG2431	L-lysine efflux transmembrane transporter activity
VM_09110	COG0076	glutamate decarboxylase activity
VM_09115	COG1737	Transcriptional regulator
VM_09120	COG1979	alcohol dehydrogenase
VM_09130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VM_09140	COG0542	response to heat
VM_09145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VM_09150	COG1278	Cold shock
VM_09155	COG1943	Transposase
VM_09165	COG1187	pseudouridine synthase activity
VM_09170	COG0140	phosphoribosyl-ATP diphosphatase activity
VM_09170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VM_09175	COG0107	imidazoleglycerol-phosphate synthase activity
VM_09180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VM_09185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VM_09190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VM_09190	COG0131	Imidazoleglycerol-phosphate dehydratase
VM_09195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VM_09200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VM_09205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VM_09210	COG1757	Na H antiporter
VM_09215	COG2916	Histone family protein nucleoid-structuring protein H-NS
VM_09220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VM_09225	COG0482	sulfurtransferase activity
VM_09230	COG2915	High frequency lysogenization protein hflD homolog
VM_09235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VM_09240	COG2268	Band 7 protein
VM_09250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VM_09265	COG0300	oxidoreductase activity
VM_09275	COG0501	Belongs to the peptidase M48B family
VM_09285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VM_09290	COG2226	methyltransferase
VM_09295	COG0156	8-amino-7-oxononanoate synthase activity
VM_09300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VM_09305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VM_09310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VM_09315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VM_09320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VM_09330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VM_09335	COG3706	GGDEF domain
VM_09345	COG4120	Belongs to the binding-protein-dependent transport system permease family
VM_09355	COG4628	conserved protein (DUF2132)
VM_09360	COG3092	negative regulation of chromosome organization
VM_09365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VM_09370	COG0280	phosphate acetyltransferase
VM_09370	COG0857	belongs to the CobB CobQ family
VM_09375	COG0435	Glutathione S-transferase
VM_09380	COG4608	Belongs to the ABC transporter superfamily
VM_09390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VM_09395	COG0601	transmembrane transport
VM_09415	COG2204	response regulator
VM_09420	COG3300	MHYT domain
VM_09420	COG5001	Diguanylate cyclase
VM_09425	COG4191	Histidine kinase
VM_09430	COG5002	protein histidine kinase activity
VM_09440	COG2201	protein-glutamate methylesterase activity
VM_09455	COG0009	L-threonylcarbamoyladenylate synthase
VM_09475	COG1881	PFAM PEBP family protein
VM_09500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_09505	COG3716	PTS system mannose fructose sorbose family IID component
VM_09515	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VM_09520	COG2222	sugar isomerase
VM_09530	COG1349	DNA-binding transcription factor activity
VM_09535	COG1349	DNA-binding transcription factor activity
VM_09550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VM_09555	COG0640	Transcriptional regulator
VM_09560	COG0590	tRNA wobble adenosine to inosine editing
VM_09565	COG2076	Multidrug Resistance protein
VM_09570	COG2076	Multidrug Resistance protein
VM_09575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
VM_09595	COG1120	ATPase activity
VM_09600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VM_09610	COG4264	IucA IucC family
VM_09635	COG2801	Transposase and inactivated derivatives
VM_09665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VM_09670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VM_09755	COG1396	sequence-specific DNA binding
VM_09780	COG3300	MHYT domain
VM_09780	COG5001	Diguanylate cyclase
VM_09800	COG1946	Acyl-CoA thioesterase
VM_09805	COG1522	sequence-specific DNA binding
VM_09815	COG0616	signal peptide processing
VM_09820	COG1028	Short-chain dehydrogenase reductase Sdr
VM_09835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VM_09840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VM_09845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VM_09850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VM_09855	COG2832	Protein of unknown function (DUF454)
VM_09865	COG0745	RESPONSE REGULATOR receiver
VM_09870	COG0583	DNA-binding transcription factor activity
VM_09875	COG0778	Nitroreductase
VM_09880	COG1024	Enoyl-CoA hydratase
VM_09880	COG1250	3-hydroxyacyl-CoA dehydrogenase
VM_09885	COG0183	Belongs to the thiolase family
VM_09900	COG2067	long-chain fatty acid transport protein
VM_09905	COG2067	long-chain fatty acid transport protein
VM_09910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VM_09915	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VM_09920	COG2982	Protein involved in outer membrane biogenesis
VM_09925	COG0572	uridine kinase
VM_09935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VM_09935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VM_09945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VM_09955	COG0516	GMP reductase activity
VM_09955	COG0517	IMP dehydrogenase activity
VM_09960	COG3706	GGDEF domain
VM_09965	COG0314	molybdopterin synthase activity
VM_09970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VM_09975	COG0315	cyclic pyranopterin monophosphate synthase activity
VM_09980	COG0521	Mo-molybdopterin cofactor biosynthetic process
VM_09985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VM_09990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VM_09995	COG2198	Histidine kinase
VM_10000	COG2204	response regulator
VM_10005	COG0556	nucleotide-excision repair
VM_10020	COG3119	arylsulfatase activity
VM_10025	COG0641	radical SAM
VM_10030	COG0714	Associated with various cellular activities
VM_10065	COG4657	Part of a membrane complex involved in electron transport
VM_10070	COG2878	Part of a membrane complex involved in electron transport
VM_10075	COG4656	Part of a membrane complex involved in electron transport
VM_10080	COG4658	electron transport chain
VM_10085	COG4659	FMN binding
VM_10090	COG4660	Part of a membrane complex involved in electron transport
VM_10095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VM_10100	COG0346	lactoylglutathione lyase activity
VM_10120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VM_10125	COG2056	Na+-H+ antiporter family
VM_10130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VM_10135	COG1286	toxin biosynthetic process
VM_10140	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VM_10145	COG0285	dihydrofolate synthase activity
VM_10155	COG0101	tRNA pseudouridine synthase activity
VM_10165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VM_10170	COG1263	PTS System
VM_10170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VM_10170	COG2190	(PTS) system
VM_10175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VM_10180	COG1940	carbohydrate kinase activity
VM_10180	COG1846	Transcriptional regulator
VM_10185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VM_10185	COG4651	solute:proton antiporter activity
VM_10190	COG0367	asparagine synthase
VM_10195	COG0250	Participates in transcription elongation, termination and antitermination
VM_10200	COG3104	oligopeptide transport
VM_10205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VM_10210	COG0563	adenylate kinase activity
VM_10215	COG0326	Molecular chaperone. Has ATPase activity
VM_10220	COG3710	Transcriptional regulator
VM_10235	COG0622	Phosphoesterase
VM_10240	COG1090	epimerase
VM_10245	COG0300	oxidoreductase activity
VM_10250	COG3118	belongs to the thioredoxin family
VM_10255	COG0330	HflC and HflK could
VM_10260	COG1585	Membrane protein implicated in regulation of membrane protease activity
VM_10265	COG0789	Transcriptional regulator
VM_10280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VM_10285	COG3115	cell septum assembly
VM_10290	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VM_10295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VM_10305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_10315	COG2190	(PTS) system
VM_10320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VM_10325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VM_10330	COG1702	phosphate starvation-inducible protein PhoH
VM_10335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VM_10340	COG4535	Mg2 and Co2 transporter CorC
VM_10345	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VM_10350	COG2888	peptidyl-tyrosine sulfation
VM_10355	COG0495	leucyl-tRNA aminoacylation
VM_10360	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VM_10365	COG1466	dna polymerase III delta subunit
VM_10370	COG0799	negative regulation of ribosome biogenesis
VM_10375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VM_10380	COG0768	penicillin binding
VM_10385	COG0772	Belongs to the SEDS family
VM_10390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VM_10395	COG1686	Belongs to the peptidase S11 family
VM_10400	COG2921	Belongs to the UPF0250 family
VM_10405	COG0321	lipoyl(octanoyl) transferase activity
VM_10410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VM_10420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VM_10445	COG1596	polysaccharide export
VM_10455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VM_10485	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VM_10505	COG1045	serine acetyltransferase
VM_10530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VM_10535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VM_10545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VM_10585	COG2205	protein histidine kinase activity
VM_10590	COG0745	RESPONSE REGULATOR receiver
VM_10595	COG0366	Alpha amylase catalytic
VM_10600	COG1263	PTS System
VM_10600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VM_10605	COG1609	Transcriptional regulator
VM_10610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VM_10615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VM_10620	COG2011	ABC-type metal ion transport system permease component
VM_10625	COG1464	Belongs to the NlpA lipoprotein family
VM_10630	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VM_10640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VM_10640	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VM_10650	COG3706	GGDEF domain
VM_10655	COG1611	Belongs to the LOG family
VM_10660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VM_10665	COG2363	Small membrane protein
VM_10670	COG0583	DNA-binding transcription factor activity
VM_10680	COG0301	tRNA thio-modification
VM_10680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VM_10690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VM_10695	COG1722	exodeoxyribonuclease VII activity
VM_10700	COG0142	geranyltranstransferase activity
VM_10705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VM_10710	COG0564	pseudouridine synthase activity
VM_10740	COG1671	Belongs to the UPF0178 family
VM_10745	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VM_10750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VM_10755	COG0254	rRNA binding
VM_10760	COG1720	tRNA m6t6A37 methyltransferase activity
VM_10765	COG0442	prolyl-tRNA aminoacylation
VM_10785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VM_10785	COG0047	phosphoribosylformylglycinamidine synthase activity
VM_10795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VM_10805	COG0590	tRNA wobble adenosine to inosine editing
VM_10810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VM_10845	COG0484	heat shock protein binding
VM_10850	COG0443	Heat shock 70 kDa protein
VM_10855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VM_10860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VM_10865	COG0497	DNA recombination
VM_10870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VM_10875	COG2914	Belongs to the UPF0125 (RnfH) family
VM_10880	COG2867	negative regulation of translational initiation
VM_10885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VM_10895	COG0582	viral genome integration into host DNA
VM_10905	COG3423	Transcriptional regulator
VM_10910	COG2801	Transposase and inactivated derivatives
VM_10915	COG2842	Transposition protein
VM_11035	COG0640	Transcriptional regulator
VM_11045	COG4373	Mu-like prophage FluMu protein gp28
VM_11050	COG4383	Mu-like prophage protein gp29
VM_11080	COG4397	Mu-like prophage major head subunit gpT
VM_11090	COG4387	Mu-like prophage protein GP36
VM_11120	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
VM_11140	COG4384	Bacteriophage Mu Gp45 protein
VM_11150	COG3299	homolog of phage Mu protein gp47
VM_11155	COG3778	Protein conserved in bacteria
VM_11175	COG2801	Transposase and inactivated derivatives
VM_11180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VM_11185	COG0732	type I restriction modification DNA specificity domain
VM_11190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VM_11205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VM_11210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VM_11215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VM_11225	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VM_11230	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VM_11235	COG3051	citrate lyase alpha subunit
VM_11240	COG2301	Belongs to the HpcH HpaI aldolase family
VM_11245	COG3052	prosthetic group binding
VM_11250	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VM_11260	COG3630	sodium ion export across plasma membrane
VM_11265	COG0511	ligase activity, forming carbon-carbon bonds
VM_11265	COG5016	pyruvate
VM_11270	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VM_11280	COG4565	transcriptional regulatory protein
VM_11290	COG2200	EAL domain
VM_11305	COG0583	DNA-binding transcription factor activity
VM_11310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VM_11315	COG1115	amino acid carrier protein
VM_11320	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VM_11325	COG0583	DNA-binding transcription factor activity
VM_11330	COG1584	GPR1 FUN34 yaaH family protein
VM_11340	COG0519	Catalyzes the synthesis of GMP from XMP
VM_11340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VM_11345	COG0516	GMP reductase activity
VM_11345	COG0517	IMP dehydrogenase activity
VM_11350	COG1570	exodeoxyribonuclease VII activity
VM_11365	COG1160	GTP binding
VM_11370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VM_11375	COG2976	Protein conserved in bacteria
VM_11380	COG0124	histidyl-tRNA synthetase
VM_11385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VM_11390	COG1426	Protein conserved in bacteria
VM_11395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VM_11400	COG0105	UTP biosynthetic process
VM_11405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VM_11410	COG2975	iron-sulfur cluster assembly
VM_11415	COG0633	Ferredoxin
VM_11425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VM_11435	COG0822	iron-sulfur transferase activity
VM_11445	COG1959	2 iron, 2 sulfur cluster binding
VM_11455	COG0483	inositol monophosphate 1-phosphatase activity
VM_11460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VM_11465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VM_11470	COG1862	Preprotein translocase
VM_11475	COG0343	queuine tRNA-ribosyltransferase activity
VM_11485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VM_11490	COG0517	IMP dehydrogenase activity
VM_11495	COG0840	transmembrane signaling receptor activity
VM_11505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VM_11510	COG0583	DNA-binding transcription factor activity
VM_11515	COG0450	alkyl hydroperoxide reductase
VM_11520	COG3142	Participates in the control of copper homeostasis
VM_11535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VM_11540	COG0581	inorganic phosphate transmembrane transporter activity
VM_11550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VM_11555	COG0248	Ppx GppA phosphatase
VM_11565	COG5002	protein histidine kinase activity
VM_11570	COG0745	RESPONSE REGULATOR receiver
VM_11575	COG2974	May be involved in recombination
VM_11585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VM_11640	COG0542	response to heat
VM_11650	COG0564	pseudouridine synthase activity
VM_11655	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VM_11660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VM_11665	COG0077	Prephenate dehydratase
VM_11665	COG1605	Chorismate mutase
VM_11670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VM_11675	COG5001	Diguanylate cyclase
VM_11680	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VM_11685	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VM_11695	COG0488	(ABC) transporter
VM_11705	COG1605	Chorismate mutase
VM_11705	COG0287	Prephenate dehydrogenase
VM_11710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VM_11715	COG3275	phosphorelay sensor kinase activity
VM_11720	COG3279	Response regulator of the LytR AlgR family
VM_11725	COG1472	Belongs to the glycosyl hydrolase 3 family
VM_11730	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VM_11735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VM_11750	COG1966	Carbon starvation protein
VM_11755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VM_11760	COG1047	Peptidyl-prolyl cis-trans
VM_11765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VM_11770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VM_11775	COG0196	riboflavin kinase activity
VM_11780	COG0728	peptidoglycan biosynthetic process
VM_11785	COG0268	Binds directly to 16S ribosomal RNA
VM_11790	COG0640	Transcriptional regulator
VM_11800	COG0583	DNA-binding transcription factor activity
VM_11805	COG1283	sodium-dependent phosphate transmembrane transporter activity
VM_11810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VM_11815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VM_11820	COG0730	response to heat
VM_11825	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VM_11830	COG0494	nUDIX hydrolase
VM_11835	COG3066	DNA modification
VM_11840	COG0667	Aldo Keto reductase
VM_11855	COG2204	response regulator
VM_11860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VM_11865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VM_11880	COG0513	Belongs to the DEAD box helicase family
VM_11885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VM_11905	COG3153	acetyltransferase
VM_11935	COG1846	Transcriptional regulator
VM_11945	COG4785	May be involved in cell division
VM_11950	COG1185	polyribonucleotide nucleotidyltransferase activity
VM_11955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VM_11960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VM_11965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VM_11970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VM_11975	COG0195	Participates in both transcription termination and antitermination
VM_11980	COG0779	Required for maturation of 30S ribosomal subunits
VM_11995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VM_12005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VM_12010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VM_12015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VM_12020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VM_12025	COG1534	Rna-binding protein
VM_12030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VM_12035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VM_12040	COG2027	D-alanyl-D-alanine carboxypeptidase
VM_12045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VM_12050	COG0739	heme binding
VM_12065	COG0316	Belongs to the HesB IscA family
VM_12075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VM_12085	COG0628	permease
VM_12090	COG2813	Specifically methylates the guanine in position
VM_12100	COG0747	negative chemotaxis
VM_12110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VM_12115	COG0444	Belongs to the ABC transporter superfamily
VM_12120	COG4608	Belongs to the ABC transporter superfamily
VM_12130	COG2971	BadF BadG BcrA BcrD
VM_12145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VM_12150	COG3842	ATPase activity
VM_12160	COG1840	ABC-type Fe3 transport system, periplasmic component
VM_12165	COG0004	ammonium transporteR
VM_12170	COG0347	Belongs to the P(II) protein family
VM_12175	COG3112	Uncharacterised protein family (UPF0231)
VM_12185	COG1752	Esterase of the alpha-beta hydrolase superfamily
VM_12190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VM_12195	COG1643	Atp-dependent helicase
VM_12200	COG1489	DNA binding
VM_12205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VM_12210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VM_12220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VM_12225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VM_12230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VM_12235	COG0842	Transport permease protein
VM_12240	COG1131	(ABC) transporter
VM_12245	COG0659	secondary active sulfate transmembrane transporter activity
VM_12250	COG0288	reversible hydration of carbon dioxide
VM_12265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VM_12270	COG3107	peptidoglycan biosynthetic process
VM_12275	COG0792	nuclease activity
VM_12280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VM_12285	COG2823	Periplasmic or secreted lipoprotein
VM_12290	COG2969	positive regulation of protein catabolic process
VM_12295	COG0625	glutathione transferase activity
VM_12300	COG2857	Cytochrome c1
VM_12305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VM_12310	COG0723	plastoquinol--plastocyanin reductase activity
VM_12315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VM_12320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VM_12330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VM_12340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VM_12345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VM_12350	COG0335	large ribosomal subunit rRNA binding
VM_12355	COG0336	Belongs to the RNA methyltransferase TrmD family
VM_12360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VM_12365	COG0228	four-way junction DNA binding
VM_12370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VM_12375	COG4137	Cytochrome C assembly protein
VM_12380	COG4536	flavin adenine dinucleotide binding
VM_12385	COG1854	S-ribosylhomocysteine lyase activity
VM_12390	COG2918	glutathione biosynthetic process
VM_12395	COG0612	Peptidase, M16
VM_12400	COG1238	metal cluster binding
VM_12410	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VM_12415	COG5016	pyruvate
VM_12415	COG0511	ligase activity, forming carbon-carbon bonds
VM_12420	COG3630	sodium ion export across plasma membrane
VM_12465	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VM_12470	COG0527	aspartate kinase activity
VM_12475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VM_12480	COG2137	regulation of response to DNA damage stimulus
VM_12485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VM_12490	COG1546	Belongs to the CinA family
VM_12495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VM_12500	COG4208	sulfate ABC transporter
VM_12520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VM_12525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VM_12530	COG4942	peptidase
VM_12530	COG1388	LysM domain
VM_12535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VM_12540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VM_12545	COG0585	pseudouridine synthase activity
VM_12550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VM_12555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VM_12560	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VM_12565	COG1968	undecaprenyl-diphosphatase activity
VM_12570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VM_12575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VM_12585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VM_12590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VM_12595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VM_12600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VM_12605	COG1610	YqeY-like protein
VM_12610	COG0358	DNA primase activity
VM_12615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VM_12625	COG0582	viral genome integration into host DNA
VM_12680	COG3339	Conserved Protein
VM_12695	COG2003	Belongs to the UPF0758 family
VM_12700	COG3547	Transposase (IS116 IS110 IS902 family)
VM_12770	COG1181	Belongs to the D-alanine--D-alanine ligase family
VM_12825	COG3501	Rhs element vgr protein
VM_12840	COG2207	Transcriptional regulator
VM_12915	COG2378	regulation of single-species biofilm formation
VM_12930	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VM_12935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VM_12940	COG1349	DNA-binding transcription factor activity
VM_12945	COG0469	pyruvate kinase activity
VM_12955	COG0583	DNA-binding transcription factor activity
VM_12960	COG1279	arginine transmembrane transporter activity
VM_12965	COG0668	transmembrane transport
VM_12970	COG0191	fructose-bisphosphate aldolase activity
VM_12975	COG0126	phosphoglycerate kinase activity
VM_12980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VM_12985	COG4771	TonB-dependent receptor
VM_12990	COG0583	DNA-binding transcription factor activity
VM_12995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VM_13005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VM_13010	COG3091	SprT-like family
VM_13015	COG2356	endonuclease I
VM_13020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VM_13025	COG0189	ligase activity
VM_13030	COG1678	Uncharacterized ACR, COG1678
VM_13035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VM_13040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VM_13060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VM_13065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VM_13070	COG0762	integral membrane protein
VM_13085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VM_13090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VM_13100	COG2066	Belongs to the glutaminase family
VM_13105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VM_13110	COG1194	a g-specific adenine glycosylase
VM_13115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VM_13120	COG0741	lytic transglycosylase activity
VM_13175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VM_13180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VM_13185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VM_13190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VM_13195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VM_13200	COG2967	ApaG domain
VM_13205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VM_13215	COG3610	response to peptide
VM_13220	COG2966	Psort location CytoplasmicMembrane, score
VM_13225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VM_13230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VM_13235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VM_13240	COG0142	geranyltranstransferase activity
VM_13245	COG0531	amino acid
VM_13250	COG0039	L-malate dehydrogenase activity
VM_13255	COG1438	arginine binding
VM_13270	COG0589	response to stress
VM_13295	COG4145	pantothenate transmembrane transporter activity
VM_13305	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VM_13315	COG1737	Transcriptional regulator
VM_13315	COG0837	glucose binding
VM_13330	COG3550	peptidyl-serine autophosphorylation
VM_13360	COG2801	Transposase and inactivated derivatives
VM_13390	COG2801	Transposase and inactivated derivatives
VM_13405	COG2235	arginine
VM_13410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VM_13420	COG0312	modulator of DNA gyrase
VM_13425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VM_13430	COG3164	Protein of unknown function
VM_13435	COG1530	ribonuclease E activity
VM_13440	COG0424	maF-like protein
VM_13445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VM_13450	COG1792	Involved in formation and maintenance of cell shape
VM_13455	COG1077	Cell shape determining protein MreB Mrl
VM_13500	COG1459	type II secretion system
VM_13505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VM_13515	COG3409	Peptidoglycan-binding domain 1 protein
VM_13515	COG3267	Type II secretory pathway component ExeA
VM_13540	COG2200	EAL domain
VM_13540	COG2199	diguanylate cyclase activity
VM_13560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VM_13570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VM_13575	COG0527	aspartate kinase activity
VM_13580	COG0646	methionine synthase
VM_13580	COG1410	methionine synthase
VM_13655	COG0175	sulfate reduction
VM_13660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VM_13665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VM_13690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VM_13695	COG0735	belongs to the Fur family
VM_13705	COG0166	Belongs to the GPI family
VM_13710	COG0432	Pfam Uncharacterised protein family UPF0047
VM_13715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VM_13720	COG0305	Participates in initiation and elongation during chromosome replication
VM_13730	COG0359	binds to the 23S rRNA
VM_13735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VM_13740	COG2965	DNA replication, synthesis of RNA primer
VM_13745	COG0360	Binds together with S18 to 16S ribosomal RNA
VM_13755	COG2906	2 iron, 2 sulfur cluster binding
VM_13760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VM_13765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VM_13770	COG0049	tRNA binding
VM_13775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VM_13785	COG2923	Belongs to the DsrF TusC family
VM_13790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VM_13795	COG2964	Protein conserved in bacteria
VM_13800	COG0545	Peptidyl-prolyl cis-trans isomerase
VM_13810	COG2900	Belongs to the SlyX family
VM_13815	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VM_13820	COG0330	HflC and HflK could
VM_13825	COG0330	HflC and HflK could
VM_13830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VM_13835	COG1923	regulation of RNA biosynthetic process
VM_13840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VM_13845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VM_13850	COG0860	N-Acetylmuramoyl-L-alanine amidase
VM_13855	COG0802	atpase or kinase
VM_13860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VM_13910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VM_13915	COG1162	GTPase activity
VM_13920	COG0688	phosphatidylethanolamine metabolic process
VM_13925	COG0471	metal ion transport
VM_13935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VM_13940	COG4942	peptidase
VM_13955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VM_13960	COG2816	NAD+ diphosphatase activity
VM_13965	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VM_13970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VM_13975	COG0085	RNA polymerase activity
VM_13980	COG0222	ribosome binding
VM_13985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VM_13990	COG0081	regulation of translation
VM_13995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VM_14000	COG0250	Participates in transcription elongation, termination and antitermination
VM_14005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VM_14010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VM_14035	COG1072	(Pantothenic acid kinase))
VM_14045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VM_14060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VM_14100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VM_14110	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VM_14115	COG3118	belongs to the thioredoxin family
VM_14120	COG0513	Belongs to the DEAD box helicase family
VM_14125	COG0248	Ppx GppA phosphatase
VM_14135	COG2814	Major facilitator Superfamily
VM_14155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VM_14160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VM_14165	COG0511	ligase activity, forming carbon-carbon bonds
VM_14170	COG0439	Biotin carboxylase
VM_14180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VM_14185	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VM_14190	COG1609	Transcriptional regulator
VM_14195	COG0129	dihydroxy-acid dehydratase activity
VM_14200	COG3265	gluconokinase activity
VM_14205	COG2610	gluconate transmembrane transporter activity
VM_14210	COG0800	Aldolase
VM_14225	COG0840	transmembrane signaling receptor activity
VM_14230	COG1982	Orn Lys Arg decarboxylase major
VM_14235	COG0531	amino acid
VM_14240	COG3710	Transcriptional regulator
VM_14245	COG0789	Transcriptional regulator
VM_14250	COG0138	bifunctional purine biosynthesis protein purh
VM_14255	COG0151	Belongs to the GarS family
VM_14265	COG0776	regulation of translation
VM_14270	COG1253	flavin adenine dinucleotide binding
VM_14275	COG3068	Protein conserved in bacteria
VM_14285	COG1573	uracil-dna glycosylase
VM_14290	COG0668	transmembrane transport
VM_14295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VM_14305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VM_14315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VM_14360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VM_14375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VM_14410	COG1519	Transferase
VM_14435	COG3642	lipopolysaccharide core region biosynthetic process
VM_14440	COG0859	PFAM glycosyl transferase family 9
VM_14445	COG0463	Glycosyl transferase, family 2
VM_14450	COG0859	PFAM glycosyl transferase family 9
VM_14455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VM_14460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VM_14470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VM_14475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VM_14490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VM_14495	COG1309	transcriptional regulator
VM_14500	COG1560	Kdo2-lipid A biosynthetic process
VM_14505	COG1560	Kdo2-lipid A biosynthetic process
VM_14510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VM_14515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VM_14520	COG1561	YicC-like family, N-terminal region
VM_14530	COG1263	PTS System
VM_14530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VM_14535	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VM_14555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VM_14560	COG1120	ATPase activity
VM_14565	COG4774	siderophore transport
VM_14580	COG0514	ATP-dependent DNA helicase (RecQ)
VM_14585	COG2962	Rard protein
VM_14590	COG0405	Gamma-glutamyltransferase
VM_14600	COG1280	lysine exporter protein (LysE YggA)
VM_14610	COG0210	DNA helicase
VM_14620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VM_14625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VM_14635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VM_14645	COG0747	negative chemotaxis
VM_14695	COG1309	transcriptional regulator
VM_14700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VM_14705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VM_14710	COG2960	long-chain fatty acid transporting porin activity
VM_14715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VM_14720	COG0583	DNA-binding transcription factor activity
VM_14795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VM_14800	COG1739	Uncharacterized protein family UPF0029
VM_14805	COG1024	Enoyl-CoA hydratase
VM_14805	COG1250	3-hydroxyacyl-CoA dehydrogenase
VM_14810	COG0183	Belongs to the thiolase family
VM_14815	COG0583	DNA-binding transcription factor activity
VM_14820	COG2814	Major facilitator Superfamily
VM_14830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VM_14835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VM_14840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VM_14845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VM_14850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VM_14855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VM_14865	COG0356	it plays a direct role in the translocation of protons across the membrane
VM_14870	COG3312	ion transport
VM_14875	COG1475	DNA binding
VM_14880	COG1192	Involved in chromosome partitioning
VM_14885	COG0357	Ribosomal RNA small subunit methyltransferase G
VM_14890	COG0445	tRNA wobble uridine modification
VM_14895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VM_14945	COG1074	ATP-dependent DNA helicase activity
VM_15040	COG4974	Belongs to the 'phage' integrase family
VM_15045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VM_15050	COG0706	membrane insertase activity
VM_15055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VM_15060	COG0594	ribonuclease P activity
VM_15065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VM_15070	COG1126	abc transporter atp-binding protein
VM_15195	COG0454	-acetyltransferase
VM_15225	COG1028	Short-chain dehydrogenase reductase Sdr
VM_15245	COG1028	Short-chain dehydrogenase reductase Sdr
VM_15355	COG3040	lipid binding
VM_15425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VM_15440	COG0384	phenazine biosynthesis protein PhzF
VM_15525	COG2814	Major facilitator Superfamily
VM_15540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VM_15550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VM_15560	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VM_15590	COG4977	sequence-specific DNA binding
VM_15590	COG1917	Cupin 2, conserved barrel domain protein
VM_15600	COG1328	CTP reductase activity
VM_15605	COG0602	queuosine metabolic process
VM_15615	COG0189	ligase activity
VM_15615	COG4067	protein conserved in archaea
VM_15620	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VM_15625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_15625	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VM_15625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_15630	COG1105	Belongs to the carbohydrate kinase PfkB family
VM_15635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_15635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_15640	COG1609	Transcriptional regulator
VM_15645	COG0420	3'-5' exonuclease activity
VM_15650	COG0419	ATPase involved in DNA repair
VM_15655	COG2205	protein histidine kinase activity
VM_15655	COG0784	Response regulator, receiver
VM_15660	COG0156	8-amino-7-oxononanoate synthase activity
VM_15670	COG0038	chloride channel
VM_15675	COG0523	cobalamin synthesis protein
VM_15685	COG4409	exo-alpha-(2->6)-sialidase activity
VM_15690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VM_15695	COG1940	carbohydrate kinase activity
VM_15700	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VM_15710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VM_15715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VM_15720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VM_15725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VM_15730	COG1737	Transcriptional regulator
VM_15735	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VM_15740	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VM_15765	COG5001	Diguanylate cyclase
VM_15765	COG3300	MHYT domain
VM_15775	COG3038	cytochrome b561
VM_15785	COG2116	formate transmembrane transporter activity
VM_15790	COG0583	DNA-binding transcription factor activity
VM_15800	COG3593	DNA synthesis involved in DNA repair
VM_15805	COG0737	Belongs to the 5'-nucleotidase family
VM_15820	COG2824	Alkylphosphonate utilization operon protein PhnA
VM_15855	COG3706	GGDEF domain
VM_15865	COG1309	transcriptional regulator
VM_15885	COG0745	RESPONSE REGULATOR receiver
VM_15885	COG3706	GGDEF domain
VM_15900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VM_15905	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VM_16060	COG4771	TonB-dependent receptor
VM_16065	COG2814	Major facilitator Superfamily
VM_16070	COG3433	isochorismatase activity
VM_16070	COG2226	methyltransferase
VM_16070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VM_16085	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
VM_16095	COG1021	2,3-dihydroxybenzoate-AMP ligase
VM_16100	COG1132	(ABC) transporter
VM_16105	COG4988	ABC transporter
VM_16115	COG0023	Translation Initiation Factor
VM_16125	COG1181	Belongs to the D-alanine--D-alanine ligase family
VM_16135	COG0045	succinate-CoA ligase (ADP-forming) activity
VM_16135	COG1042	CoA-binding domain protein
VM_16135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VM_16140	COG0583	DNA-binding transcription factor activity
VM_16145	COG4771	TonB-dependent receptor
VM_16160	COG2050	protein possibly involved in aromatic compounds catabolism
VM_16180	COG0625	glutathione transferase activity
VM_16205	COG4172	Belongs to the ABC transporter superfamily
VM_16210	COG4239	(ABC) transporter, permease
VM_16215	COG4174	ABC transporter (Permease)
VM_16220	COG4166	transmembrane transport
VM_16265	COG3842	ATPase activity
VM_16270	COG1840	ABC-type Fe3 transport system, periplasmic component
VM_16275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VM_16285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VM_16290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VM_16295	COG1011	Hydrolase
VM_16310	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VM_16315	COG1454	alcohol dehydrogenase
VM_16320	COG1970	mechanosensitive ion channel activity
VM_16325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VM_16330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VM_16330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VM_16335	COG0302	gtp cyclohydrolase
VM_16345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VM_16355	COG2897	thiosulfate sulfurtransferase activity
VM_16365	COG2390	Transcriptional regulator
VM_16370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VM_16375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VM_16405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VM_16440	COG0583	DNA-binding transcription factor activity
VM_16475	COG0640	Transcriptional regulator
VM_16495	COG1566	PFAM secretion protein HlyD family protein
VM_16550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VM_16565	COG0545	Peptidyl-prolyl cis-trans isomerase
VM_16575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VM_16580	COG0840	transmembrane signaling receptor activity
VM_16585	COG3069	C4-dicarboxylate transmembrane transporter activity
VM_16590	COG1760	l-serine dehydratase
VM_16595	COG2197	response regulator
VM_16600	COG3850	Histidine kinase
VM_16605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VM_16615	COG0243	molybdopterin cofactor binding
VM_16625	COG3005	denitrification pathway
VM_16635	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VM_16640	COG2197	response regulator
VM_16645	COG3851	Histidine kinase
VM_16650	COG2271	Major facilitator Superfamily
VM_16655	COG1840	ABC-type Fe3 transport system, periplasmic component
VM_16665	COG3842	ATPase activity
VM_16720	COG4964	Belongs to the GSP D family
VM_16740	COG0583	DNA-binding transcription factor activity
VM_16750	COG3243	poly(R)-hydroxyalkanoic acid synthase
VM_16760	COG0183	Belongs to the thiolase family
VM_16770	COG1943	Transposase
VM_16785	COG1447	Phosphotransferase system cellobiose-specific component IIA
VM_16790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VM_16800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VM_16805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VM_16820	COG3706	GGDEF domain
VM_16825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VM_16835	COG1979	alcohol dehydrogenase
VM_16850	COG4191	Histidine kinase
VM_16855	COG1840	ABC-type Fe3 transport system, periplasmic component
VM_16865	COG2271	Major facilitator Superfamily
VM_16870	COG0469	pyruvate kinase activity
VM_16875	COG2198	Histidine kinase
VM_16875	COG2205	protein histidine kinase activity
VM_16875	COG0784	Response regulator, receiver
VM_16880	COG1879	ABC-type sugar transport system periplasmic component
VM_16885	COG1803	Methylglyoxal synthase
VM_16900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VM_16920	COG0210	DNA helicase
VM_16925	COG1289	transmembrane transporter activity
VM_16945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VM_16950	COG4149	molybdate abc transporter
VM_16955	COG0725	ABC transporter, periplasmic molybdate-binding protein
VM_16960	COG1492	cobalamin metabolic process
VM_16980	COG5002	protein histidine kinase activity
VM_16980	COG0784	Response regulator, receiver
VM_16985	COG1879	ABC-type sugar transport system periplasmic component
VM_16995	COG2827	Endonuclease containing a URI domain
VM_17000	COG3132	Protein of unknown function, DUF480
VM_17020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VM_17025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VM_17035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VM_17040	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
VM_17045	COG0247	lactate metabolic process
VM_17055	COG1215	transferase activity, transferring glycosyl groups
VM_17065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VM_17070	COG3118	belongs to the thioredoxin family
VM_17105	COG0583	DNA-binding transcription factor activity
VM_17115	COG4160	amino acid transport
VM_17120	COG4215	(ABC) transporter
VM_17125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VM_17130	COG1126	abc transporter atp-binding protein
VM_17140	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VM_17150	COG0494	nUDIX hydrolase
VM_17155	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VM_17170	COG0513	Belongs to the DEAD box helicase family
VM_17175	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VM_17185	COG0814	amino acid
VM_17190	COG0840	transmembrane signaling receptor activity
VM_17195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VM_17200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VM_17205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VM_17210	COG1984	allophanate hydrolase subunit 2
VM_17225	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VM_17230	COG4181	ATPase activity
VM_17240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VM_17245	COG1716	ATPase activity
VM_17245	COG5001	Diguanylate cyclase
VM_17255	COG0484	heat shock protein binding
VM_17290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VM_17295	COG1943	Transposase
VM_17300	COG1368	sulfuric ester hydrolase activity
VM_17310	COG0513	Belongs to the DEAD box helicase family
VM_17315	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VM_17325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VM_17335	COG3046	protein related to deoxyribodipyrimidine photolyase
VM_17340	COG3397	chitin binding
VM_17370	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VM_17385	COG1172	Belongs to the binding-protein-dependent transport system permease family
VM_17390	COG1129	ABC transporter
VM_17395	COG1454	alcohol dehydrogenase
VM_17400	COG0235	Class ii aldolase
VM_17405	COG4154	Belongs to the RbsD FucU family
VM_17410	COG1070	Carbohydrate kinase
VM_17415	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
VM_17420	COG1349	DNA-binding transcription factor activity
VM_17450	COG0561	phosphatase activity
VM_17455	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VM_17460	COG3623	hexulose-6-phosphate isomerase
VM_17475	COG2149	membrane
VM_17485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VM_17485	COG1263	PTS System
VM_17490	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VM_17530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VM_17550	COG4604	ABC transporter, ATP-binding protein
VM_17555	COG4605	iron ion homeostasis
VM_17560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VM_17580	COG4412	M6 family metalloprotease domain protein
VM_17580	COG3291	Pkd domain containing protein
VM_17585	COG0840	transmembrane signaling receptor activity
VM_17595	COG3240	lipase activity
VM_17600	COG3706	GGDEF domain
VM_17610	COG2814	Major facilitator Superfamily
VM_17615	COG1757	Na H antiporter
VM_17625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VM_17625	COG4191	Histidine kinase
VM_17630	COG3437	response regulator, receiver
VM_17630	COG0784	Response regulator, receiver
VM_17635	COG0840	transmembrane signaling receptor activity
VM_17640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VM_17645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VM_17650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VM_17655	COG0513	Belongs to the DEAD box helicase family
VM_17660	COG1943	Transposase
VM_17670	COG4821	SIS domain
VM_17675	COG4821	SIS domain
VM_17685	COG3715	PTS system
VM_17690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VM_17710	COG1501	Belongs to the glycosyl hydrolase 31 family
VM_17715	COG3119	arylsulfatase activity
VM_17730	COG1917	Cupin 2, conserved barrel domain protein
VM_17730	COG2207	Transcriptional regulator
VM_17750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
VM_17755	COG2188	Transcriptional regulator
VM_17760	COG4821	SIS domain
VM_17790	COG1735	metal-dependent hydrolase with the TIM-barrel fold
VM_17800	COG0516	GMP reductase activity
VM_17810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VM_17820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VM_17825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VM_17825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VM_17850	COG3036	rescue of stalled ribosome
VM_17855	COG1278	Cold shock
VM_17860	COG1017	nitric oxide dioxygenase activity
VM_17860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VM_17865	COG3604	Transcriptional regulator
VM_17880	COG2195	Cleaves the N-terminal amino acid of tripeptides
VM_17885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VM_17900	COG0840	transmembrane signaling receptor activity
VM_17905	COG0714	Associated with various cellular activities
VM_17925	COG2304	oxidoreductase activity
VM_17940	COG1278	Cold shock
VM_17945	COG5001	Diguanylate cyclase
VM_17945	COG5002	protein histidine kinase activity
VM_17955	COG3530	Putative quorum-sensing-regulated virulence factor
VM_17965	COG3033	Beta-eliminating lyase
VM_17970	COG0814	amino acid
VM_17975	COG0488	(ABC) transporter
VM_17980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VM_17980	COG1017	nitric oxide dioxygenase activity
VM_17985	COG1609	Transcriptional regulator
VM_17990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_18005	COG0242	peptide deformylase activity
VM_18015	COG0579	oxidoreductase
VM_18040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VM_18065	COG2271	Major facilitator Superfamily
VM_18070	COG0584	glycerophosphoryl diester phosphodiesterase
VM_18080	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VM_18090	COG1609	Transcriptional regulator
VM_18095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VM_18100	COG1879	ABC-type sugar transport system periplasmic component
VM_18105	COG1172	Belongs to the binding-protein-dependent transport system permease family
VM_18110	COG1129	ABC transporter
VM_18115	COG1869	D-ribose catabolic process
VM_18140	COG3501	Rhs element vgr protein
VM_18235	COG0564	pseudouridine synthase activity
VM_18245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VM_18250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VM_18260	COG0673	inositol 2-dehydrogenase activity
VM_18265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VM_18295	COG1342	Belongs to the UPF0251 family
VM_18310	COG1301	dicarboxylic acid transport
VM_18315	COG0700	Nucleoside recognition
VM_18320	COG3366	ferrous iron transmembrane transporter activity
VM_18325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VM_18330	COG4565	transcriptional regulatory protein
VM_18340	COG0471	metal ion transport
VM_18350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VM_18355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VM_18360	COG2259	Doxx family
VM_18385	COG0363	glucosamine-6-phosphate deaminase activity
VM_18400	COG4580	involved in the transport of maltose and maltodextrins
VM_18410	COG1914	H( )-stimulated, divalent metal cation uptake system
VM_18430	COG0840	transmembrane signaling receptor activity
VM_18445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VM_18470	COG1280	lysine exporter protein (LysE YggA)
VM_18485	COG0583	DNA-binding transcription factor activity
VM_18490	COG1486	melibiose metabolic process
VM_18500	COG0513	Belongs to the DEAD box helicase family
VM_18510	COG2186	Transcriptional regulator
VM_18520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VM_18530	COG0246	Mannitol dehydrogenase
VM_18535	COG1904	glucuronate isomerase
VM_18540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VM_18545	COG0800	Aldolase
VM_18555	COG0583	DNA-binding transcription factor activity
VM_18565	COG1902	pentaerythritol trinitrate reductase activity
VM_18570	COG2964	Protein conserved in bacteria
VM_18580	COG0251	oxidation-reduction process
VM_18585	COG0814	amino acid
VM_18595	COG1132	(ABC) transporter
VM_18605	COG1280	lysine exporter protein (LysE YggA)
VM_18610	COG2207	Transcriptional regulator
VM_18630	COG1846	Transcriptional regulator
VM_18635	COG1764	response to oxidative stress
VM_18640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VM_18645	COG0697	spore germination
VM_18650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VM_18650	COG0678	peroxiredoxin activity
VM_18665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VM_18670	COG0583	DNA-binding transcription factor activity
VM_18675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VM_18680	COG0569	domain protein
VM_18685	COG0745	RESPONSE REGULATOR receiver
VM_18690	COG2205	protein histidine kinase activity
VM_18705	COG2814	Major facilitator Superfamily
VM_18710	COG0583	DNA-binding transcription factor activity
VM_18720	COG0739	heme binding
VM_18730	COG0659	secondary active sulfate transmembrane transporter activity
VM_18750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VM_18755	COG0581	inorganic phosphate transmembrane transporter activity
VM_18760	COG0573	inorganic phosphate transmembrane transporter activity
VM_18765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VM_18775	COG0513	Belongs to the DEAD box helicase family
VM_18785	COG1376	ErfK ybiS ycfS ynhG family protein
VM_18785	COG1388	LysM domain
VM_18790	COG0415	Belongs to the DNA photolyase family
VM_18795	COG0789	Transcriptional regulator
VM_18800	COG3272	Protein of unknown function (DUF1722)
VM_18810	COG0813	purine-nucleoside phosphorylase activity
VM_18835	COG1566	PFAM secretion protein HlyD family protein
VM_18850	COG3655	Transcriptional regulator
VM_18865	COG0786	glutamate:sodium symporter activity
VM_18880	COG1999	signal sequence binding
VM_18890	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VM_18900	COG0671	phosphoesterase, PA-phosphatase related
VM_18930	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VM_18935	COG0471	metal ion transport
VM_18970	COG3501	Rhs element vgr protein
VM_18980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VM_18985	COG1640	4-alpha-glucanotransferase
VM_18990	COG0058	SHG alpha-glucan phosphorylase activity
VM_18995	COG2909	trisaccharide binding
VM_19010	COG2084	Dehydrogenase
VM_19015	COG0217	transcriptional regulatory protein
VM_19055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VM_19060	COG1444	tRNA N-acetyltransferase activity
VM_19070	COG1022	Amp-dependent synthetase and ligase
VM_19080	COG1028	Short-chain dehydrogenase reductase Sdr
VM_19090	COG0745	RESPONSE REGULATOR receiver
VM_19095	COG0642	Histidine kinase
VM_19100	COG2194	sulfuric ester hydrolase activity
VM_19110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VM_19115	COG0601	transmembrane transport
VM_19120	COG0747	negative chemotaxis
VM_19130	COG0745	RESPONSE REGULATOR receiver
VM_19135	COG0643	Histidine kinase
VM_19135	COG2198	Histidine kinase
VM_19140	COG0835	chemotaxis
VM_19145	COG0835	chemotaxis
VM_19150	COG0840	transmembrane signaling receptor activity
VM_19155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VM_19160	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VM_19180	COG3706	GGDEF domain
VM_19180	COG0745	RESPONSE REGULATOR receiver
VM_19210	COG0259	pyridoxamine-phosphate oxidase activity
VM_19220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VM_19245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VM_19295	COG2197	response regulator
VM_19300	COG1982	Orn Lys Arg decarboxylase major
VM_19305	COG0531	amino acid
VM_19310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VM_19320	COG1901	pseudouridine methyltransferase
VM_19335	COG4221	oxidoreductase activity
VM_19350	COG2910	NAD(P)H-binding
VM_19370	COG0655	NAD(P)H dehydrogenase (quinone) activity
VM_19375	COG0583	DNA-binding transcription factor activity
VM_19390	COG0697	spore germination
VM_19420	COG0673	inositol 2-dehydrogenase activity
VM_19425	COG3722	fumarate hydratase activity
VM_19430	COG0246	Mannitol dehydrogenase
VM_19435	COG2213	PTS system mannitol-specific
VM_19435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_19440	COG0739	heme binding
VM_19450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VM_19455	COG4597	amino acid ABC transporter
VM_19460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VM_19470	COG1126	abc transporter atp-binding protein
VM_19475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VM_19480	COG0534	Mate efflux family protein
VM_19485	COG0840	transmembrane signaling receptor activity
VM_19490	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VM_19495	COG1366	Belongs to the anti-sigma-factor antagonist family
VM_19505	COG2172	sigma factor antagonist activity
VM_19520	COG3437	response regulator, receiver
VM_19530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VM_19540	COG1304	FMN binding
VM_19545	COG1620	l-lactate permease
VM_19550	COG0583	DNA-binding transcription factor activity
VM_19555	COG4172	Belongs to the ABC transporter superfamily
VM_19565	COG1067	ATP-dependent peptidase activity
VM_19580	COG2211	Major facilitator Superfamily
VM_19590	COG3123	guanosine phosphorylase activity
VM_19595	COG1741	Belongs to the pirin family
VM_19605	COG5001	Diguanylate cyclase
VM_19645	COG3706	GGDEF domain
VM_19650	COG1846	Transcriptional regulator
VM_19655	COG0784	Response regulator, receiver
VM_19655	COG0835	chemotaxis
VM_19660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VM_19675	COG0583	DNA-binding transcription factor activity
VM_19685	COG2197	response regulator
VM_19690	COG0393	Putative heavy-metal-binding
VM_19700	COG1388	LysM domain
VM_19700	COG0741	lytic transglycosylase activity
VM_19720	COG1815	bacterial-type flagellum-dependent cell motility
VM_19725	COG1558	bacterial-type flagellum-dependent cell motility
VM_19730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VM_19735	COG1749	Flagellar hook protein flgE
VM_19740	COG4787	bacterial-type flagellum-dependent cell motility
VM_19745	COG4786	Flagellar basal body rod
VM_19750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VM_19755	COG1706	bacterial-type flagellum-dependent cell motility
VM_19765	COG1256	bacterial-type flagellum assembly
VM_19765	COG4786	Flagellar basal body rod
VM_19785	COG1360	Flagellar Motor Protein
VM_19790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VM_19795	COG1191	sigma factor activity
VM_19800	COG1580	Controls the rotational direction of flagella during chemotaxis
VM_19820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VM_19830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VM_19850	COG1987	bacterial-type flagellum assembly
VM_19875	COG2204	response regulator
VM_19880	COG1677	Flagellar hook-basal body complex protein FliE
VM_19890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VM_19910	COG2801	Transposase and inactivated derivatives
VM_19920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_19920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_19920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_19925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_19925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VM_19925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VM_19935	COG1349	DNA-binding transcription factor activity
VM_19950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VM_19955	COG3842	ATPase activity
VM_19965	COG1175	transmembrane transport
VM_19970	COG3833	ABC-type maltose transport systems, permease component
VM_19985	COG0737	Belongs to the 5'-nucleotidase family
VM_19995	COG1349	DNA-binding transcription factor activity
VM_20025	COG1278	Cold shock
VM_20035	COG0488	(ABC) transporter
VM_20040	COG2354	Protein conserved in bacteria
VM_20045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VM_20055	COG3152	Membrane
VM_20065	COG0418	dihydroorotase activity
VM_20070	COG0633	Ferredoxin
VM_20070	COG3217	Mosc domain protein beta barrel domain protein
VM_20070	COG0633	Ferredoxin
VM_20070	COG3217	Mosc domain protein beta barrel domain protein
VM_20110	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VM_20115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VM_20120	COG4558	Periplasmic binding protein
VM_20125	COG0848	biopolymer transport protein
VM_20130	COG0811	peptide transport
VM_20135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VM_20145	COG3721	Heme iron utilization protein
VM_20150	COG0748	coenzyme F420 binding
VM_20160	COG1858	cytochrome C peroxidase
VM_20165	COG3835	regulator
VM_20170	COG2610	gluconate transmembrane transporter activity
VM_20175	COG1929	Belongs to the glycerate kinase type-1 family
VM_20195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VM_20200	COG0363	glucosamine-6-phosphate deaminase activity
VM_20205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VM_20210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VM_20225	COG2203	Gaf domain
VM_20225	COG3706	GGDEF domain
VM_20225	COG4251	negative regulation of phosphorylation
VM_20225	COG5001	Diguanylate cyclase
VM_20240	COG0346	lactoylglutathione lyase activity
VM_20250	COG2873	o-acetylhomoserine
VM_20255	COG0156	8-amino-7-oxononanoate synthase activity
VM_20260	COG1063	alcohol dehydrogenase
VM_20270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VM_20280	COG2801	Transposase and inactivated derivatives
VM_20290	COG0640	Transcriptional regulator
VM_20300	COG1686	Belongs to the peptidase S11 family
VM_20310	COG3047	cAMP biosynthetic process
VM_20330	COG0366	Alpha amylase catalytic
VM_20350	COG0577	efflux transmembrane transporter activity
VM_20350	COG1136	(ABC) transporter
VM_20365	COG3275	phosphorelay sensor kinase activity
VM_20370	COG3279	Response regulator of the LytR AlgR family
VM_20380	COG3706	GGDEF domain
VM_20385	COG0531	amino acid
VM_20430	COG1765	OsmC-like protein
VM_20435	COG1253	flavin adenine dinucleotide binding
VM_20440	COG2171	N-acyltransferase activity
VM_20450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VM_20465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VM_20470	COG3186	Phenylalanine-4-hydroxylase
VM_20475	COG2154	pterin-4-alpha-carbinolamine dehydratase
VM_20485	COG0534	Mate efflux family protein
VM_20500	COG0456	acetyltransferase
VM_20505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VM_20510	COG0662	Cupin 2, conserved barrel domain protein
VM_20515	COG0527	aspartate kinase activity
VM_20520	COG2239	Acts as a magnesium transporter
VM_20545	COG1166	arginine decarboxylase activity
VM_20570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VM_20575	COG0800	Aldolase
VM_20580	COG1085	galactose-1-phosphate uridylyltransferase
VM_20585	COG1028	Short-chain dehydrogenase reductase Sdr
VM_20600	COG1943	Transposase
VM_20615	COG3119	arylsulfatase activity
VM_20620	COG3119	arylsulfatase activity
VM_20625	COG0641	radical SAM
VM_20640	COG0601	transmembrane transport
VM_20645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VM_20660	COG1414	Transcriptional regulator
VM_20665	COG1686	Belongs to the peptidase S11 family
VM_20680	COG3338	carbonate dehydratase activity
VM_20685	COG2755	lipolytic protein G-D-S-L family
VM_20690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VM_20690	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VM_20695	COG0509	glycine decarboxylation via glycine cleavage system
VM_20700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VM_20710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VM_20715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VM_20725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VM_20730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit