locus-tag	class	description
NP431_00010	COG0592	DNA-directed DNA polymerase activity
NP431_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP431_00020	COG0187	DNA topoisomerase II activity
NP431_00025	COG0071	Belongs to the small heat shock protein (HSP20) family
NP431_00030	COG3977	Valine--pyruvate aminotransferase
NP431_00035	COG0366	Alpha amylase catalytic
NP431_00040	COG0751	glycine-tRNA ligase activity
NP431_00050	COG2119	membrane
NP431_00060	COG0425	Belongs to the sulfur carrier protein TusA family
NP431_00075	COG0604	alcohol dehydrogenase
NP431_00080	COG0183	Belongs to the thiolase family
NP431_00085	COG1024	Enoyl-CoA hydratase
NP431_00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP431_00090	COG1739	Uncharacterized protein family UPF0029
NP431_00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP431_00135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_00135	COG1263	PTS System
NP431_00140	COG2205	protein histidine kinase activity
NP431_00150	COG0583	DNA-binding transcription factor activity
NP431_00155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP431_00160	COG2960	long-chain fatty acid transporting porin activity
NP431_00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP431_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_00175	COG1309	transcriptional regulator
NP431_00225	COG4166	transmembrane transport
NP431_00230	COG0601	transmembrane transport
NP431_00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP431_00245	COG1609	Transcriptional regulator
NP431_00250	COG0129	dihydroxy-acid dehydratase activity
NP431_00255	COG3265	gluconokinase activity
NP431_00260	COG2610	gluconate transmembrane transporter activity
NP431_00265	COG0800	Aldolase
NP431_00270	COG3721	Heme iron utilization protein
NP431_00275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP431_00280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NP431_00290	COG1522	sequence-specific DNA binding
NP431_00295	COG0742	ribosomal rna small subunit methyltransferase
NP431_00310	COG0589	response to stress
NP431_00315	COG1528	Iron-storage protein
NP431_00325	COG2081	HI0933 family
NP431_00355	COG4964	Belongs to the GSP D family
NP431_00405	COG0748	coenzyme F420 binding
NP431_00415	COG4988	ABC transporter
NP431_00420	COG1132	(ABC) transporter
NP431_00440	COG1322	Protein conserved in bacteria
NP431_00445	COG2226	methyltransferase
NP431_00450	COG3165	ubiquinone biosynthetic process from chorismate
NP431_00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NP431_00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP431_00470	COG0805	protein transport
NP431_00475	COG3263	regulation of cellular component size
NP431_00480	COG0084	hydrolase, TatD family'
NP431_00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP431_00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP431_00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NP431_00535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NP431_00545	COG2204	response regulator
NP431_00550	COG3852	Histidine kinase
NP431_00560	COG0174	glutamine synthetase
NP431_00565	COG1217	gtp-binding protein TYPA
NP431_00580	COG1295	ribonuclease BN
NP431_00585	COG1490	D-aminoacyl-tRNA deacylase activity
NP431_00590	COG0456	acetyltransferase
NP431_00600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NP431_00605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NP431_00610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NP431_00615	COG3031	protein transport across the cell outer membrane
NP431_00625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP431_00630	COG1459	type II secretion system
NP431_00635	COG2165	general secretion pathway protein
NP431_00640	COG2165	general secretion pathway protein
NP431_00645	COG2165	general secretion pathway protein
NP431_00650	COG4795	General secretion pathway protein
NP431_00655	COG3156	type II secretion system protein K
NP431_00660	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NP431_00665	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NP431_00675	COG1218	3'(2'),5'-bisphosphate nucleotidase
NP431_00680	COG0494	nUDIX hydrolase
NP431_00690	COG1040	competence protein
NP431_00695	COG0596	Alpha beta hydrolase
NP431_00705	COG2183	response to ionizing radiation
NP431_00715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP431_00735	COG2233	PERMEase
NP431_00740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NP431_00745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP431_00750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP431_00755	COG1758	RNA polymerase activity
NP431_00760	COG0194	GDP metabolic process
NP431_00775	COG0848	biopolymer transport protein
NP431_00780	COG0811	peptide transport
NP431_00800	COG4174	ABC transporter (Permease)
NP431_00805	COG4239	(ABC) transporter, permease
NP431_00810	COG0747	negative chemotaxis
NP431_00815	COG0444	Belongs to the ABC transporter superfamily
NP431_00820	COG4608	Belongs to the ABC transporter superfamily
NP431_00845	COG1561	YicC-like family, N-terminal region
NP431_00850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP431_00855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NP431_00860	COG1560	Kdo2-lipid A biosynthetic process
NP431_00865	COG1309	transcriptional regulator
NP431_00870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP431_00875	COG2003	Belongs to the UPF0758 family
NP431_00895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP431_00900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP431_00905	COG0438	transferase activity, transferring glycosyl groups
NP431_00910	COG0859	PFAM glycosyl transferase family 9
NP431_00920	COG0438	transferase activity, transferring glycosyl groups
NP431_00925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP431_00930	COG3642	lipopolysaccharide core region biosynthetic process
NP431_00935	COG0562	UDP-galactopyranose mutase
NP431_00950	COG1519	Transferase
NP431_00955	COG0859	PFAM glycosyl transferase family 9
NP431_00960	COG1560	Kdo2-lipid A biosynthetic process
NP431_00970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP431_00990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP431_00995	COG2895	sulfate adenylyltransferase (ATP) activity
NP431_01005	COG0529	Catalyzes the synthesis of activated sulfate
NP431_01010	COG0175	sulfate reduction
NP431_01015	COG0471	metal ion transport
NP431_01015	COG3273	potassium ion transport
NP431_01090	COG1091	dTDP-4-dehydrorhamnose reductase activity
NP431_01120	COG1682	transport, permease protein
NP431_01150	COG0489	protein tyrosine kinase activity
NP431_01150	COG3206	protein involved in exopolysaccharide biosynthesis
NP431_01155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NP431_01185	COG0438	transferase activity, transferring glycosyl groups
NP431_01195	COG0438	transferase activity, transferring glycosyl groups
NP431_01195	COG0297	glycogen (starch) synthase activity
NP431_01205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP431_01215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP431_01225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NP431_01235	COG0149	triose-phosphate isomerase activity
NP431_01250	COG3152	Membrane
NP431_01265	COG1494	fructose-1,6-bisphosphatase
NP431_01275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NP431_01280	COG1575	Belongs to the MenA family. Type 1 subfamily
NP431_01285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NP431_01300	COG1609	Transcriptional regulator
NP431_01305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP431_01310	COG0254	rRNA binding
NP431_01320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP431_01325	COG0088	Forms part of the polypeptide exit tunnel
NP431_01335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NP431_01340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NP431_01345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NP431_01350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP431_01360	COG0255	Belongs to the universal ribosomal protein uL29 family
NP431_01365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP431_01375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NP431_01380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP431_01395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP431_01410	COG1841	ribosomal large subunit assembly
NP431_01415	COG0200	Binds to the 23S rRNA
NP431_01420	COG0201	protein transport
NP431_01425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP431_01430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP431_01435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP431_01445	COG0202	RNA polymerase activity
NP431_01450	COG0203	ribosomal protein L17
NP431_01460	COG0545	Peptidyl-prolyl cis-trans isomerase
NP431_01470	COG2153	protein acetylation
NP431_01475	COG0513	Belongs to the DEAD box helicase family
NP431_01485	COG0737	Belongs to the 5'-nucleotidase family
NP431_01490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP431_01490	COG1648	precorrin-2 dehydrogenase activity
NP431_01495	COG0175	sulfate reduction
NP431_01500	COG2895	sulfate adenylyltransferase (ATP) activity
NP431_01505	COG0471	metal ion transport
NP431_01505	COG3273	potassium ion transport
NP431_01510	COG0529	Catalyzes the synthesis of activated sulfate
NP431_01530	COG1136	(ABC) transporter
NP431_01545	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NP431_01555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP431_01565	COG2911	Protein conserved in bacteria
NP431_01570	COG2105	PFAM AIG2 family protein
NP431_01575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NP431_01580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NP431_01585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP431_01590	COG0163	prenyltransferase activity
NP431_01600	COG1178	ABC-type Fe3 transport system permease component
NP431_01605	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NP431_01630	COG0039	L-malate dehydrogenase activity
NP431_01640	COG0142	geranyltranstransferase activity
NP431_01645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP431_01655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP431_01660	COG2966	Psort location CytoplasmicMembrane, score
NP431_01670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP431_01680	COG2967	ApaG domain
NP431_01685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP431_01690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NP431_01695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP431_01700	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NP431_01705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NP431_01715	COG0066	3-isopropylmalate dehydratase activity
NP431_01725	COG0473	3-isopropylmalate dehydrogenase activity
NP431_01730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP431_01740	COG0671	phosphoesterase, PA-phosphatase related
NP431_01750	COG0583	DNA-binding transcription factor activity
NP431_01755	COG1022	Amp-dependent synthetase and ligase
NP431_01760	COG0028	Belongs to the TPP enzyme family
NP431_01765	COG0440	acetolactate synthase activity
NP431_01770	COG0469	pyruvate kinase activity
NP431_01775	COG1349	DNA-binding transcription factor activity
NP431_01780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP431_01790	COG1263	PTS System
NP431_01790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_01795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NP431_01800	COG3722	fumarate hydratase activity
NP431_01805	COG0246	Mannitol dehydrogenase
NP431_01810	COG2213	PTS system mannitol-specific
NP431_01810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP431_01850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP431_01865	COG0358	DNA primase activity
NP431_01870	COG1610	YqeY-like protein
NP431_01875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NP431_01880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP431_01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NP431_01890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NP431_01895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP431_01900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP431_01905	COG1968	undecaprenyl-diphosphatase activity
NP431_01910	COG0617	tRNA 3'-terminal CCA addition
NP431_01915	COG3267	Type II secretory pathway component ExeA
NP431_01915	COG3409	Peptidoglycan-binding domain 1 protein
NP431_01925	COG4991	sh3 domain protein
NP431_01930	COG0306	phosphate transporter
NP431_01935	COG1392	Phosphate transport regulator
NP431_01940	COG3025	triphosphatase activity
NP431_01955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NP431_01965	COG1538	Outer membrane efflux protein
NP431_01970	COG0494	nUDIX hydrolase
NP431_01975	COG3151	Protein conserved in bacteria
NP431_01985	COG3150	esterase
NP431_01995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP431_02000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP431_02010	COG3105	Protein conserved in bacteria
NP431_02015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NP431_02020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NP431_02025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NP431_02030	COG0723	plastoquinol--plastocyanin reductase activity
NP431_02035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP431_02040	COG2857	Cytochrome c1
NP431_02045	COG0625	glutathione transferase activity
NP431_02050	COG2969	positive regulation of protein catabolic process
NP431_02055	COG2823	Periplasmic or secreted lipoprotein
NP431_02060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NP431_02075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NP431_02085	COG0275	rRNA processing
NP431_02090	COG3116	cell division
NP431_02095	COG0768	penicillin binding
NP431_02100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP431_02105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP431_02110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP431_02115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP431_02120	COG0772	Belongs to the SEDS family
NP431_02125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP431_02130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP431_02135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP431_02140	COG0849	cell division
NP431_02145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP431_02150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NP431_02160	COG0653	protein targeting
NP431_02165	COG0494	nUDIX hydrolase
NP431_02175	COG0505	Belongs to the CarA family
NP431_02180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP431_02185	COG0730	response to heat
NP431_02190	COG0583	DNA-binding transcription factor activity
NP431_02195	COG2860	membrane
NP431_02200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP431_02210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP431_02220	COG0493	'glutamate synthase
NP431_02225	COG0067	glutamate synthase
NP431_02225	COG0070	glutamate synthase
NP431_02225	COG0069	glutamate synthase activity
NP431_02235	COG0070	glutamate synthase
NP431_02235	COG0069	glutamate synthase activity
NP431_02235	COG0067	glutamate synthase
NP431_02240	COG1242	4 iron, 4 sulfur cluster binding
NP431_02245	COG0784	Response regulator, receiver
NP431_02245	COG2198	Histidine kinase
NP431_02245	COG5002	protein histidine kinase activity
NP431_02255	COG0745	RESPONSE REGULATOR receiver
NP431_02265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NP431_02280	COG0083	homoserine kinase activity
NP431_02285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP431_02290	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
NP431_02295	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NP431_02300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP431_02315	COG1115	amino acid carrier protein
NP431_02320	COG3022	response to hydroperoxide
NP431_02325	COG0513	Belongs to the DEAD box helicase family
NP431_02330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NP431_02345	COG4974	Belongs to the 'phage' integrase family
NP431_02350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP431_02355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP431_02365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NP431_02370	COG3829	transcription factor binding
NP431_02370	COG3290	protein histidine kinase activity
NP431_02380	COG0667	Aldo Keto reductase
NP431_02390	COG3066	DNA modification
NP431_02405	COG0730	response to heat
NP431_02410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP431_02415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NP431_02425	COG1283	sodium-dependent phosphate transmembrane transporter activity
NP431_02430	COG0583	DNA-binding transcription factor activity
NP431_02435	COG0640	Transcriptional regulator
NP431_02440	COG0268	Binds directly to 16S ribosomal RNA
NP431_02445	COG0728	peptidoglycan biosynthetic process
NP431_02450	COG0196	riboflavin kinase activity
NP431_02455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP431_02460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP431_02465	COG1047	Peptidyl-prolyl cis-trans
NP431_02470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP431_02475	COG3279	Response regulator of the LytR AlgR family
NP431_02480	COG3275	phosphorelay sensor kinase activity
NP431_02485	COG1966	Carbon starvation protein
NP431_02505	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NP431_02510	COG1472	Belongs to the glycosyl hydrolase 3 family
NP431_02515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NP431_02520	COG0287	Prephenate dehydrogenase
NP431_02520	COG1605	Chorismate mutase
NP431_02525	COG0739	heme binding
NP431_02530	COG0488	(ABC) transporter
NP431_02540	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
NP431_02545	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
NP431_02550	COG0077	Prephenate dehydratase
NP431_02550	COG1605	Chorismate mutase
NP431_02555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP431_02560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NP431_02565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP431_02570	COG0564	pseudouridine synthase activity
NP431_02580	COG0542	response to heat
NP431_02595	COG1116	anion transmembrane transporter activity
NP431_02650	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
NP431_02660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NP431_02665	COG0826	peptidase U32
NP431_02670	COG2974	May be involved in recombination
NP431_02675	COG0745	RESPONSE REGULATOR receiver
NP431_02680	COG5002	protein histidine kinase activity
NP431_02690	COG0248	Ppx GppA phosphatase
NP431_02695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NP431_02705	COG0581	inorganic phosphate transmembrane transporter activity
NP431_02710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP431_02715	COG0704	Plays a role in the regulation of phosphate uptake
NP431_02725	COG3142	Participates in the control of copper homeostasis
NP431_02730	COG0450	alkyl hydroperoxide reductase
NP431_02735	COG0583	DNA-binding transcription factor activity
NP431_02740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NP431_02750	COG0517	IMP dehydrogenase activity
NP431_02760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NP431_02765	COG0343	queuine tRNA-ribosyltransferase activity
NP431_02770	COG1862	Preprotein translocase
NP431_02775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP431_02780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP431_02785	COG0483	inositol monophosphate 1-phosphatase activity
NP431_02790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NP431_02800	COG1104	cysteine desulfurase activity
NP431_02805	COG0822	iron-sulfur transferase activity
NP431_02820	COG0443	Heat shock 70 kDa protein
NP431_02825	COG0633	Ferredoxin
NP431_02830	COG2975	iron-sulfur cluster assembly
NP431_02835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP431_02840	COG0105	UTP biosynthetic process
NP431_02855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP431_02860	COG0124	histidyl-tRNA synthetase
NP431_02865	COG2976	Protein conserved in bacteria
NP431_02870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP431_02875	COG1160	GTP binding
NP431_02895	COG0517	IMP dehydrogenase activity
NP431_02895	COG0516	GMP reductase activity
NP431_02900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP431_02900	COG0519	Catalyzes the synthesis of GMP from XMP
NP431_02915	COG1584	GPR1 FUN34 yaaH family protein
NP431_02930	COG1473	amidohydrolase
NP431_02940	COG1115	amino acid carrier protein
NP431_02945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_02955	COG2873	o-acetylhomoserine
NP431_02960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP431_02980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP431_02980	COG3153	acetyltransferase
NP431_02985	COG0583	DNA-binding transcription factor activity
NP431_02990	COG0235	Class ii aldolase
NP431_02995	COG4806	L-rhamnose isomerase
NP431_03000	COG1070	Carbohydrate kinase
NP431_03005	COG3254	rhamnose metabolic process
NP431_03040	COG2197	response regulator
NP431_03050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP431_03055	COG2867	negative regulation of translational initiation
NP431_03060	COG2914	Belongs to the UPF0125 (RnfH) family
NP431_03065	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP431_03070	COG0497	DNA recombination
NP431_03075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP431_03080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP431_03085	COG1301	dicarboxylic acid transport
NP431_03095	COG0484	heat shock protein binding
NP431_03125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NP431_03140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NP431_03145	COG0047	phosphoribosylformylglycinamidine synthase activity
NP431_03145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP431_03180	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP431_03185	COG2252	PERMEase
NP431_03190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NP431_03195	COG1073	alpha beta
NP431_03205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP431_03210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP431_03215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP431_03220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP431_03220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP431_03235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NP431_03245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NP431_03250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP431_03260	COG0142	geranyltranstransferase activity
NP431_03270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP431_03275	COG2885	chlorophyll binding
NP431_03280	COG0301	tRNA thio-modification
NP431_03280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP431_03285	COG0583	DNA-binding transcription factor activity
NP431_03295	COG2363	Small membrane protein
NP431_03300	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NP431_03305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP431_03310	COG1611	Belongs to the LOG family
NP431_03325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP431_03325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP431_03335	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NP431_03340	COG1464	Belongs to the NlpA lipoprotein family
NP431_03345	COG2011	ABC-type metal ion transport system permease component
NP431_03350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NP431_03355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NP431_03365	COG1263	PTS System
NP431_03365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_03370	COG0366	Alpha amylase catalytic
NP431_03380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP431_03385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP431_03390	COG0321	lipoyl(octanoyl) transferase activity
NP431_03400	COG1686	Belongs to the peptidase S11 family
NP431_03405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP431_03410	COG0772	Belongs to the SEDS family
NP431_03415	COG0768	penicillin binding
NP431_03425	COG0799	negative regulation of ribosome biogenesis
NP431_03430	COG1466	dna polymerase III delta subunit
NP431_03435	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NP431_03440	COG0495	leucyl-tRNA aminoacylation
NP431_03445	COG2888	peptidyl-tyrosine sulfation
NP431_03450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NP431_03455	COG4535	Mg2 and Co2 transporter CorC
NP431_03465	COG1702	phosphate starvation-inducible protein PhoH
NP431_03470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP431_03475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP431_03585	COG0012	GTP binding
NP431_03595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP431_03600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP431_03605	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NP431_03610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP431_03620	COG2890	protein-(glutamine-N5) methyltransferase activity
NP431_03625	COG3094	Invasion gene expression up-regulator, SirB
NP431_03630	COG2912	Transglutaminase-like superfamily
NP431_03635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NP431_03640	COG0737	Belongs to the 5'-nucleotidase family
NP431_03645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP431_03650	COG1187	pseudouridine synthase activity
NP431_03655	COG2840	Smr protein MutS2
NP431_03685	COG2217	Heavy metal translocating P-type atpase
NP431_03685	COG2608	mercury ion transmembrane transporter activity
NP431_03740	COG0784	Response regulator, receiver
NP431_03740	COG0835	chemotaxis
NP431_03745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NP431_03750	COG1815	bacterial-type flagellum-dependent cell motility
NP431_03755	COG1558	bacterial-type flagellum-dependent cell motility
NP431_03765	COG1749	Flagellar hook protein flgE
NP431_03770	COG4787	bacterial-type flagellum-dependent cell motility
NP431_03780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NP431_03785	COG1706	bacterial-type flagellum-dependent cell motility
NP431_03790	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP431_03790	COG3951	Flagellar rod assembly protein muramidase FlgJ
NP431_03800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP431_03805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP431_03810	COG2190	(PTS) system
NP431_03815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP431_03820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP431_03825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP431_03830	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NP431_03835	COG3115	cell septum assembly
NP431_03840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NP431_03865	COG0330	HflC and HflK could
NP431_03870	COG3118	belongs to the thioredoxin family
NP431_03875	COG0300	oxidoreductase activity
NP431_03880	COG1090	epimerase
NP431_03910	COG0622	Phosphoesterase
NP431_03930	COG3710	Transcriptional regulator
NP431_03935	COG0326	Molecular chaperone. Has ATPase activity
NP431_03945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP431_03950	COG3104	oligopeptide transport
NP431_03955	COG0250	Participates in transcription elongation, termination and antitermination
NP431_03960	COG0367	asparagine synthase
NP431_03965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP431_03965	COG4651	solute:proton antiporter activity
NP431_03970	COG1846	Transcriptional regulator
NP431_03970	COG1940	carbohydrate kinase activity
NP431_03975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP431_03980	COG2190	(PTS) system
NP431_03980	COG1263	PTS System
NP431_03980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_03985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP431_03990	COG0735	belongs to the Fur family
NP431_04010	COG0596	Alpha beta hydrolase
NP431_04015	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NP431_04020	COG0033	Phosphoglucomutase
NP431_04030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NP431_04045	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NP431_04050	COG1053	succinate dehydrogenase
NP431_04060	COG0567	Dehydrogenase, E1 component
NP431_04065	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP431_04070	COG0045	succinate-CoA ligase (ADP-forming) activity
NP431_04080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP431_04085	COG1121	(ABC) transporter
NP431_04090	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NP431_04095	COG4977	sequence-specific DNA binding
NP431_04100	COG1918	ferrous iron import across plasma membrane
NP431_04120	COG0018	arginyl-trna synthetase
NP431_04125	COG3102	Protein conserved in bacteria
NP431_04140	COG0788	formyltetrahydrofolate deformylase activity
NP431_04145	COG1199	ATP-dependent helicase activity
NP431_04150	COG1214	PFAM Peptidase M22, glycoprotease
NP431_04165	COG2267	carboxylic ester hydrolase activity
NP431_04170	COG0318	PFAM AMP-dependent synthetase and ligase
NP431_04175	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NP431_04180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NP431_04185	COG2894	cell division
NP431_04200	COG2951	lytic endotransglycosylase activity
NP431_04205	COG0583	DNA-binding transcription factor activity
NP431_04210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP431_04215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP431_04225	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_04235	COG1169	isochorismate synthase
NP431_04240	COG1021	2,3-dihydroxybenzoate-AMP ligase
NP431_04245	COG3433	isochorismatase activity
NP431_04245	COG1535	isochorismatase
NP431_04250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP431_04250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP431_04265	COG4771	TonB-dependent receptor
NP431_04270	COG1253	flavin adenine dinucleotide binding
NP431_04275	COG0513	Belongs to the DEAD box helicase family
NP431_04280	COG0569	domain protein
NP431_04285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP431_04295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NP431_04315	COG1175	transmembrane transport
NP431_04325	COG3842	ATPase activity
NP431_04330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP431_04335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP431_04340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP431_04350	COG2204	response regulator
NP431_04370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NP431_04375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NP431_04380	COG0776	regulation of translation
NP431_04385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP431_04390	COG1555	photosystem II stabilization
NP431_04405	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NP431_04410	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NP431_04415	COG0436	Aminotransferase
NP431_04420	COG1169	isochorismate synthase
NP431_04425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP431_04430	COG0596	Alpha beta hydrolase
NP431_04435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NP431_04455	COG2855	membrane
NP431_04460	COG0477	Major facilitator Superfamily
NP431_04500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_04505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP431_04520	COG1522	sequence-specific DNA binding
NP431_04525	COG1946	Acyl-CoA thioesterase
NP431_04530	COG3126	Type III secretion system lipoprotein chaperone (YscW)
NP431_04610	COG5290	Psort location Cytoplasmic, score
NP431_04645	COG0583	DNA-binding transcription factor activity
NP431_04655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_04660	COG0174	glutamine synthetase
NP431_04665	COG0174	glutamine synthetase
NP431_04675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NP431_04680	COG3842	ATPase activity
NP431_04685	COG1176	ABC-type spermidine putrescine transport system, permease component I
NP431_04690	COG1177	transmembrane transport
NP431_04700	COG1012	belongs to the aldehyde dehydrogenase family
NP431_04705	COG0519	Catalyzes the synthesis of GMP from XMP
NP431_04710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP431_04715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NP431_04720	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NP431_04725	COG0516	GMP reductase activity
NP431_04725	COG0517	IMP dehydrogenase activity
NP431_04750	COG0537	adenosine 5'-monophosphoramidase activity
NP431_04775	COG3150	esterase
NP431_04780	COG1252	NADH dehydrogenase
NP431_04795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NP431_04805	COG4591	ABC-type transport system involved in lipoprotein release permease component
NP431_04810	COG1136	(ABC) transporter
NP431_04815	COG4591	ABC-type transport system involved in lipoprotein release permease component
NP431_04825	COG0658	competence protein
NP431_04825	COG2333	competence protein COMEC
NP431_04830	COG1132	(ABC) transporter
NP431_04845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NP431_04850	COG2719	SpoVR family
NP431_04855	COG2718	Belongs to the UPF0229 family
NP431_04860	COG2766	serine protein kinase
NP431_04875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NP431_04885	COG1882	Formate acetyltransferase
NP431_04920	COG0708	Exodeoxyribonuclease III
NP431_04925	COG0583	DNA-binding transcription factor activity
NP431_04935	COG1346	cytolysis
NP431_04945	COG3923	Primosomal replication protein n
NP431_04950	COG0730	response to heat
NP431_04955	COG1199	ATP-dependent helicase activity
NP431_04965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NP431_04970	COG1187	pseudouridine synthase activity
NP431_04980	COG1278	Cold shock
NP431_04985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NP431_04990	COG0542	response to heat
NP431_04995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NP431_05000	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NP431_05005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NP431_05015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NP431_05025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP431_05030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP431_05035	COG0297	glycogen (starch) synthase activity
NP431_05055	COG3070	regulator of competence-specific genes
NP431_05060	COG1609	Transcriptional regulator
NP431_05065	COG3381	protein complex oligomerization
NP431_05070	COG0745	RESPONSE REGULATOR receiver
NP431_05075	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NP431_05080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP431_05085	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
NP431_05090	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NP431_05095	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NP431_05130	COG4067	protein conserved in archaea
NP431_05130	COG0189	ligase activity
NP431_05135	COG0500	methyltransferase
NP431_05140	COG4106	trans-aconitate 2-methyltransferase activity
NP431_05145	COG1801	Protein of unknown function DUF72
NP431_05155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NP431_05160	COG0632	four-way junction helicase activity
NP431_05165	COG2255	four-way junction helicase activity
NP431_05170	COG1271	oxidase subunit
NP431_05175	COG1294	oxidase, subunit
NP431_05180	COG4890	Cyd operon protein YbgT
NP431_05190	COG0824	Thioesterase
NP431_05195	COG0811	peptide transport
NP431_05210	COG0823	Involved in the tonB-independent uptake of proteins
NP431_05215	COG2885	chlorophyll binding
NP431_05220	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NP431_05225	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP431_05235	COG3766	membrane
NP431_05245	COG0754	glutathionylspermidine amidase activity
NP431_05260	COG1858	cytochrome C peroxidase
NP431_05280	COG2205	protein histidine kinase activity
NP431_05280	COG0784	Response regulator, receiver
NP431_05325	COG3052	prosthetic group binding
NP431_05340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP431_05345	COG1396	sequence-specific DNA binding
NP431_05350	COG3135	benzoate transporter
NP431_05355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_05360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP431_05395	COG0686	Belongs to the AlaDH PNT family
NP431_05405	COG1674	ftsk spoiiie
NP431_05410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NP431_05415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NP431_05425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP431_05430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NP431_05435	COG0156	8-amino-7-oxononanoate synthase activity
NP431_05445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NP431_05455	COG0501	Belongs to the peptidase M48B family
NP431_05465	COG4221	oxidoreductase activity
NP431_05480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NP431_05500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP431_05510	COG0482	sulfurtransferase activity
NP431_05520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP431_05530	COG1757	Na H antiporter
NP431_05545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NP431_05550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP431_05555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NP431_05560	COG0131	Imidazoleglycerol-phosphate dehydratase
NP431_05560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NP431_05565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP431_05570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NP431_05575	COG0107	imidazoleglycerol-phosphate synthase activity
NP431_05580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NP431_05580	COG0140	phosphoribosyl-ATP diphosphatase activity
NP431_05585	COG3012	SEC-C Motif Domain Protein
NP431_05590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP431_05595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP431_05600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP431_05605	COG0215	cysteine-tRNA ligase activity
NP431_05610	COG1435	thymidine kinase activity
NP431_05615	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NP431_05630	COG2116	formate transmembrane transporter activity
NP431_05640	COG0390	transport system, permease component
NP431_05645	COG4459	periplasmic nitrate reductase
NP431_05650	COG3005	denitrification pathway
NP431_05655	COG0243	molybdopterin cofactor binding
NP431_05670	COG1227	inorganic diphosphatase activity
NP431_05680	COG4172	Belongs to the ABC transporter superfamily
NP431_05705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP431_05710	COG1842	Phage shock protein A
NP431_05720	COG1983	PspC domain protein
NP431_05740	COG2818	Glycosylase
NP431_05745	COG0626	cystathionine gamma-synthase activity
NP431_05755	COG0733	neurotransmitter:sodium symporter activity
NP431_05760	COG0564	pseudouridine synthase activity
NP431_05770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP431_05775	COG1151	hydroxylamine reductase activity
NP431_05780	COG3604	Transcriptional regulator
NP431_05790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP431_05795	COG4136	ATPase activity
NP431_05800	COG4135	transport system, permease component
NP431_05805	COG4134	Bacterial extracellular solute-binding protein
NP431_05815	COG3313	Fe-S protein
NP431_05830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NP431_05835	COG0642	Histidine kinase
NP431_05850	COG1061	Type III restriction enzyme res subunit
NP431_05855	COG1187	pseudouridine synthase activity
NP431_05860	COG2814	Major facilitator Superfamily
NP431_05890	COG3005	denitrification pathway
NP431_05895	COG0702	epimerase
NP431_05900	COG0534	Mate efflux family protein
NP431_05905	COG1136	(ABC) transporter
NP431_05920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NP431_05930	COG1960	acyl-CoA dehydrogenase activity
NP431_05935	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP431_05940	COG3273	potassium ion transport
NP431_05940	COG2985	domain, Protein
NP431_05945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP431_05950	COG1454	alcohol dehydrogenase
NP431_05950	COG1012	belongs to the aldehyde dehydrogenase family
NP431_05955	COG1737	Transcriptional regulator
NP431_05960	COG0076	glutamate decarboxylase activity
NP431_05970	COG2431	L-lysine efflux transmembrane transporter activity
NP431_05980	COG3070	regulator of competence-specific genes
NP431_05995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_05995	COG4191	Histidine kinase
NP431_06005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NP431_06015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP431_06020	COG4988	ABC transporter
NP431_06025	COG0492	ferredoxin-NADP+ reductase activity
NP431_06045	COG0471	metal ion transport
NP431_06050	COG2949	membrane
NP431_06055	COG0281	malic enzyme
NP431_06060	COG1643	Atp-dependent helicase
NP431_06075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP431_06110	COG0247	lactate metabolic process
NP431_06110	COG0277	FAD linked oxidase domain protein
NP431_06115	COG2020	methyltransferase activity
NP431_06120	COG0583	DNA-binding transcription factor activity
NP431_06125	COG3384	dioxygenase
NP431_06130	COG0435	Glutathione S-transferase
NP431_06140	COG0010	Belongs to the arginase family
NP431_06145	COG1228	amidohydrolase
NP431_06165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP431_06175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP431_06190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NP431_06195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP431_06195	COG0072	phenylalanine-tRNA ligase activity
NP431_06200	COG1621	beta-fructofuranosidase activity
NP431_06205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP431_06220	COG0776	regulation of translation
NP431_06230	COG0500	methyltransferase
NP431_06235	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NP431_06240	COG0295	cytidine deaminase activity
NP431_06245	COG1346	cytolysis
NP431_06250	COG1380	Effector of murein hydrolase LrgA
NP431_06255	COG2925	Exonuclease
NP431_06340	COG1484	DNA-dependent DNA replication
NP431_06500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP431_06515	COG1823	symporter activity
NP431_06520	COG0702	epimerase
NP431_06525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP431_06535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NP431_06555	COG2988	succinylglutamate desuccinylase activity
NP431_06560	COG4139	cobalamin transport
NP431_06585	COG0583	DNA-binding transcription factor activity
NP431_06595	COG1451	nucleotide metabolic process
NP431_06660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NP431_06665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP431_06680	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP431_06690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NP431_06700	COG0625	glutathione transferase activity
NP431_06750	COG2814	Major facilitator Superfamily
NP431_06810	COG1129	ABC transporter
NP431_06815	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP431_06820	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP431_06840	COG1609	Transcriptional regulator
NP431_06845	COG1263	PTS System
NP431_06845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_06845	COG2190	(PTS) system
NP431_06850	COG2723	6-phospho-beta-galactosidase activity
NP431_06855	COG4580	involved in the transport of maltose and maltodextrins
NP431_06860	COG4145	pantothenate transmembrane transporter activity
NP431_06865	COG3924	membrane
NP431_06885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP431_06895	COG1349	DNA-binding transcription factor activity
NP431_06900	COG0561	phosphatase activity
NP431_06915	COG0579	oxidoreductase
NP431_06945	COG4638	Rieske (2fe-2S)
NP431_06950	COG0583	DNA-binding transcription factor activity
NP431_06955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP431_07070	COG1953	Uracil, thiamine, allantoin
NP431_07085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP431_07100	COG2059	Chromate
NP431_07105	COG2059	Chromate
NP431_07135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP431_07145	COG1414	Transcriptional regulator
NP431_07155	COG0400	carboxylic ester hydrolase activity
NP431_07165	COG0784	Response regulator, receiver
NP431_07165	COG5002	protein histidine kinase activity
NP431_07165	COG2198	Histidine kinase
NP431_07175	COG0559	Belongs to the binding-protein-dependent transport system permease family
NP431_07195	COG0829	nickel cation binding
NP431_07200	COG0831	urea catabolic process
NP431_07205	COG0832	Belongs to the urease beta subunit family
NP431_07210	COG0804	urea catabolic process
NP431_07220	COG0830	nickel cation binding
NP431_07225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NP431_07235	COG0471	metal ion transport
NP431_07240	COG4191	Histidine kinase
NP431_07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_07260	COG0814	amino acid
NP431_07280	COG1132	(ABC) transporter
NP431_07285	COG1132	(ABC) transporter
NP431_07300	COG0443	Heat shock 70 kDa protein
NP431_07305	COG0443	Heat shock 70 kDa protein
NP431_07340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP431_07345	COG1643	Atp-dependent helicase
NP431_07360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP431_07370	COG1793	dna ligase
NP431_07380	COG0534	Mate efflux family protein
NP431_07385	COG0307	riboflavin synthase, alpha
NP431_07395	COG3001	Fructosamine kinase
NP431_07405	COG3706	GGDEF domain
NP431_07415	COG0791	NLP P60 protein
NP431_07420	COG0840	transmembrane signaling receptor activity
NP431_07435	COG3148	PFAM DTW domain containing protein
NP431_07440	COG1940	carbohydrate kinase activity
NP431_07455	COG0303	'Molybdopterin
NP431_07465	COG3842	ATPase activity
NP431_07480	COG2204	response regulator
NP431_07485	COG4191	Histidine kinase
NP431_07490	COG0488	(ABC) transporter
NP431_07495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP431_07525	COG3383	formate dehydrogenase (NAD+) activity
NP431_07525	COG0243	molybdopterin cofactor binding
NP431_07530	COG0437	4 iron, 4 sulfur cluster binding
NP431_07545	COG0110	maltose O-acetyltransferase activity
NP431_07550	COG2207	Transcriptional regulator
NP431_07555	COG0534	Mate efflux family protein
NP431_07560	COG0004	ammonium transporteR
NP431_07570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NP431_07575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NP431_07585	COG1177	transmembrane transport
NP431_07595	COG3842	ATPase activity
NP431_07610	COG0037	tRNA processing
NP431_07615	COG0589	response to stress
NP431_07620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP431_07635	COG2217	Heavy metal translocating P-type atpase
NP431_07645	COG2010	Cytochrome c
NP431_07660	COG3278	Belongs to the heme-copper respiratory oxidase family
NP431_07675	COG2205	protein histidine kinase activity
NP431_07675	COG0784	Response regulator, receiver
NP431_07730	COG3120	sequence-specific DNA binding
NP431_07735	COG1067	ATP-dependent peptidase activity
NP431_07740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP431_07755	COG0488	(ABC) transporter
NP431_07765	COG0116	Belongs to the methyltransferase superfamily
NP431_07765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP431_07775	COG0167	dihydroorotate dehydrogenase activity
NP431_07780	COG2902	Dehydrogenase
NP431_07790	COG0308	aminopeptidase N
NP431_07805	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NP431_07810	COG1956	GAF domain-containing protein
NP431_07815	COG1132	(ABC) transporter
NP431_07820	COG2995	paraquat-inducible protein a
NP431_07825	COG3008	intermembrane lipid transfer
NP431_07830	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NP431_07830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP431_07850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NP431_07855	COG1666	GTP binding
NP431_07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_07875	COG4597	amino acid ABC transporter
NP431_07880	COG0765	amino acid transport
NP431_07885	COG1126	abc transporter atp-binding protein
NP431_07890	COG0670	Belongs to the BI1 family
NP431_07900	COG2920	part of a sulfur-relay system
NP431_07905	COG1254	Belongs to the acylphosphatase family
NP431_07910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP431_07925	COG2885	chlorophyll binding
NP431_07935	COG3706	GGDEF domain
NP431_07945	COG0602	queuosine metabolic process
NP431_07950	COG0561	phosphatase activity
NP431_07960	COG0110	maltose O-acetyltransferase activity
NP431_07980	COG5001	Diguanylate cyclase
NP431_08000	COG1051	belongs to the nudix hydrolase family
NP431_08015	COG2828	Protein conserved in bacteria
NP431_08025	COG0372	Belongs to the citrate synthase family
NP431_08030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NP431_08060	COG0730	response to heat
NP431_08065	COG2358	TRAP transporter, solute receptor (TAXI family
NP431_08070	COG1012	belongs to the aldehyde dehydrogenase family
NP431_08075	COG3284	Transcriptional regulator
NP431_08090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP431_08095	COG0363	glucosamine-6-phosphate deaminase activity
NP431_08100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP431_08110	COG4774	siderophore transport
NP431_08115	COG4565	transcriptional regulatory protein
NP431_08120	COG3290	protein histidine kinase activity
NP431_08135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_08150	COG0527	aspartate kinase activity
NP431_08160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP431_08165	COG0456	acetyltransferase
NP431_08175	COG4176	ABC-type proline glycine betaine transport system permease component
NP431_08180	COG2113	Glycine betaine
NP431_08200	COG4221	oxidoreductase activity
NP431_08210	COG0745	RESPONSE REGULATOR receiver
NP431_08215	COG0642	Histidine kinase
NP431_08220	COG1368	sulfuric ester hydrolase activity
NP431_08240	COG1404	Belongs to the peptidase S8 family
NP431_08255	COG1115	amino acid carrier protein
NP431_08270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP431_08275	COG1280	lysine exporter protein (LysE YggA)
NP431_08280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NP431_08285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP431_08305	COG1560	Kdo2-lipid A biosynthetic process
NP431_08315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NP431_08320	COG3063	Type IV pilus biogenesis stability protein PilW
NP431_08350	COG2315	Protein conserved in bacteria
NP431_08355	COG1846	Transcriptional regulator
NP431_08365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP431_08370	COG1012	belongs to the aldehyde dehydrogenase family
NP431_08375	COG2957	Belongs to the agmatine deiminase family
NP431_08385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_08390	COG1012	belongs to the aldehyde dehydrogenase family
NP431_08395	COG1396	sequence-specific DNA binding
NP431_08395	COG1917	Cupin 2, conserved barrel domain protein
NP431_08405	COG0174	glutamine synthetase
NP431_08410	COG1757	Na H antiporter
NP431_08435	COG1126	abc transporter atp-binding protein
NP431_08440	COG0765	amino acid transport
NP431_08445	COG4597	amino acid ABC transporter
NP431_08450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_08465	COG2824	Alkylphosphonate utilization operon protein PhnA
NP431_08470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP431_08500	COG0346	lactoylglutathione lyase activity
NP431_08535	COG4977	sequence-specific DNA binding
NP431_08555	COG0724	RNA recognition motif
NP431_08575	COG0745	RESPONSE REGULATOR receiver
NP431_08580	COG5002	protein histidine kinase activity
NP431_08580	COG5000	phosphorelay sensor kinase activity
NP431_08610	COG1454	alcohol dehydrogenase
NP431_08615	COG2610	gluconate transmembrane transporter activity
NP431_08625	COG3718	enzyme involved in inositol metabolism
NP431_08630	COG0673	inositol 2-dehydrogenase activity
NP431_08635	COG0477	Major facilitator Superfamily
NP431_08635	COG2814	Major facilitator Superfamily
NP431_08640	COG1082	Xylose isomerase domain protein TIM barrel
NP431_08650	COG1082	Xylose isomerase domain protein TIM barrel
NP431_08660	COG1012	belongs to the aldehyde dehydrogenase family
NP431_08660	COG1454	alcohol dehydrogenase
NP431_08665	COG3962	Belongs to the TPP enzyme family
NP431_08670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP431_08685	COG2999	glutathione oxidoreductase activity
NP431_08705	COG2885	chlorophyll binding
NP431_08705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NP431_08770	COG0489	protein tyrosine kinase activity
NP431_08770	COG3206	protein involved in exopolysaccharide biosynthesis
NP431_08775	COG0297	glycogen (starch) synthase activity
NP431_08785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP431_08800	COG5492	domain, Protein
NP431_08840	COG2732	(Barnase) inhibitor
NP431_08850	COG2226	methyltransferase
NP431_08955	COG4220	transposase activity
NP431_09000	COG1403	HNH endonuclease
NP431_09075	COG5532	Uncharacterized conserved protein (DUF2303)
NP431_09105	COG0582	viral genome integration into host DNA
NP431_09130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP431_09140	COG3768	UPF0283 membrane protein
NP431_09145	COG3106	COG3106 Predicted ATPase
NP431_09170	COG0814	amino acid
NP431_09175	COG1760	l-serine dehydratase
NP431_09180	COG0720	synthase
NP431_09185	COG0017	Asparaginyl-tRNA synthetase
NP431_09195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP431_09205	COG1448	Aminotransferase
NP431_09220	COG2176	DNA-directed DNA polymerase activity
NP431_09230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP431_09235	COG1846	Transcriptional regulator
NP431_09260	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NP431_09275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP431_09280	COG3108	Peptidase M15
NP431_09285	COG2989	Protein conserved in bacteria
NP431_09310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP431_09325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP431_09330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP431_09345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP431_09375	COG0019	diaminopimelate decarboxylase activity
NP431_09415	COG0322	excinuclease ABC activity
NP431_09420	COG2197	response regulator
NP431_09425	COG0417	DNA replication proofreading
NP431_09435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP431_09440	COG3099	Belongs to the UPF0263 family
NP431_09445	COG1187	pseudouridine synthase activity
NP431_09455	COG0009	L-threonylcarbamoyladenylate synthase
NP431_09460	COG0613	PHP domain protein
NP431_09470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP431_09475	COG0512	Glutamine amidotransferase of anthranilate synthase
NP431_09480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP431_09485	COG0135	phosphoribosylanthranilate isomerase activity
NP431_09485	COG0134	indole-3-glycerol-phosphate synthase activity
NP431_09490	COG0133	tryptophan synthase activity
NP431_09495	COG0159	tryptophan synthase activity
NP431_09500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP431_09505	COG0318	PFAM AMP-dependent synthetase and ligase
NP431_09510	COG1301	dicarboxylic acid transport
NP431_09535	COG2350	Protein conserved in bacteria
NP431_09545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP431_09550	COG0583	DNA-binding transcription factor activity
NP431_09565	COG5001	Diguanylate cyclase
NP431_09570	COG1032	radical SAM domain protein
NP431_09575	COG0745	RESPONSE REGULATOR receiver
NP431_09580	COG5002	protein histidine kinase activity
NP431_09580	COG3850	Histidine kinase
NP431_09615	COG3118	belongs to the thioredoxin family
NP431_09620	COG4232	protein-disulfide reductase activity
NP431_09625	COG0189	ligase activity
NP431_09630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP431_09640	COG2308	Evidence 4 Homologs of previously reported genes of
NP431_09655	COG2307	Protein conserved in bacteria
NP431_09655	COG2308	Evidence 4 Homologs of previously reported genes of
NP431_09690	COG2863	cytochrome
NP431_09695	COG3258	Cytochrome c
NP431_09700	COG2995	paraquat-inducible protein a
NP431_09705	COG3008	intermembrane lipid transfer
NP431_09705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NP431_09710	COG3009	Protein conserved in bacteria
NP431_09715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP431_09725	COG0463	Glycosyl transferase, family 2
NP431_09740	COG4166	transmembrane transport
NP431_09750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NP431_09755	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
NP431_09765	COG0539	negative regulation of cytoplasmic translation
NP431_09770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NP431_09775	COG0616	signal peptide processing
NP431_09780	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_09795	COG0587	DNA-directed DNA polymerase activity
NP431_09800	COG1940	carbohydrate kinase activity
NP431_09805	COG0469	pyruvate kinase activity
NP431_09810	COG4667	esterase of the alpha-beta hydrolase superfamily
NP431_09825	COG0733	neurotransmitter:sodium symporter activity
NP431_09840	COG1263	PTS System
NP431_09840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_09850	COG1263	PTS System
NP431_09850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_09850	COG2190	(PTS) system
NP431_09855	COG0084	hydrolase, TatD family'
NP431_09860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NP431_09865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP431_09870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP431_09900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP431_09905	COG0416	fatty acid biosynthetic process
NP431_09915	COG1399	metal-binding, possibly nucleic acid-binding protein
NP431_09920	COG0424	maF-like protein
NP431_09925	COG0564	pseudouridine synthase activity
NP431_09930	COG1530	ribonuclease E activity
NP431_09935	COG0659	secondary active sulfate transmembrane transporter activity
NP431_09940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP431_09945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NP431_09955	COG0572	uridine kinase
NP431_09960	COG0489	protein tyrosine kinase activity
NP431_09965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP431_09965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP431_09975	COG2186	Transcriptional regulator
NP431_09980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NP431_09985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NP431_09990	COG0653	protein targeting
NP431_09995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP431_10000	COG2199	diguanylate cyclase activity
NP431_10005	COG0366	Alpha amylase catalytic
NP431_10010	COG1122	ATPase activity
NP431_10015	COG4120	Belongs to the binding-protein-dependent transport system permease family
NP431_10025	COG3092	negative regulation of chromosome organization
NP431_10030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP431_10035	COG0280	phosphate acetyltransferase
NP431_10035	COG0857	belongs to the CobB CobQ family
NP431_10040	COG3174	membrane
NP431_10045	COG0435	Glutathione S-transferase
NP431_10055	COG0444	Belongs to the ABC transporter superfamily
NP431_10060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP431_10065	COG0601	transmembrane transport
NP431_10075	COG0314	molybdopterin synthase activity
NP431_10080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP431_10085	COG0315	cyclic pyranopterin monophosphate synthase activity
NP431_10090	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP431_10095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP431_10100	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP431_10105	COG2198	Histidine kinase
NP431_10110	COG2204	response regulator
NP431_10115	COG0556	nucleotide-excision repair
NP431_10125	COG4657	Part of a membrane complex involved in electron transport
NP431_10130	COG2878	Part of a membrane complex involved in electron transport
NP431_10135	COG4656	Part of a membrane complex involved in electron transport
NP431_10140	COG4658	electron transport chain
NP431_10145	COG4659	FMN binding
NP431_10150	COG4660	Part of a membrane complex involved in electron transport
NP431_10155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NP431_10160	COG0346	lactoylglutathione lyase activity
NP431_10170	COG2885	chlorophyll binding
NP431_10175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NP431_10180	COG2056	Na+-H+ antiporter family
NP431_10190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NP431_10205	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_10210	COG1012	belongs to the aldehyde dehydrogenase family
NP431_10210	COG1454	alcohol dehydrogenase
NP431_10215	COG2095	MarC family integral membrane protein
NP431_10220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP431_10225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP431_10230	COG1757	Na H antiporter
NP431_10245	COG3081	Nucleoid-associated protein
NP431_10250	COG3082	Protein of unknown function (DUF1414)
NP431_10265	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP431_10275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP431_10280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP431_10285	COG1120	ATPase activity
NP431_10290	COG1522	sequence-specific DNA binding
NP431_10295	COG0626	cystathionine gamma-synthase activity
NP431_10300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_10305	COG0765	amino acid transport
NP431_10315	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP431_10325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP431_10330	COG0778	Nitroreductase
NP431_10335	COG0446	pyridine nucleotide-disulphide oxidoreductase
NP431_10335	COG1902	pentaerythritol trinitrate reductase activity
NP431_10340	COG0616	signal peptide processing
NP431_10345	COG0252	asparaginase activity
NP431_10350	COG3139	Protein of unknown function (DUF1315)
NP431_10360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP431_10365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP431_10375	COG2226	methyltransferase
NP431_10390	COG1785	Belongs to the alkaline phosphatase family
NP431_10395	COG0668	transmembrane transport
NP431_10405	COG2261	transglycosylase associated protein
NP431_10415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP431_10420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP431_10435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP431_10440	COG2832	Protein of unknown function (DUF454)
NP431_10450	COG0745	RESPONSE REGULATOR receiver
NP431_10455	COG0583	DNA-binding transcription factor activity
NP431_10460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NP431_10465	COG1286	toxin biosynthetic process
NP431_10470	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NP431_10475	COG0285	dihydrofolate synthase activity
NP431_10480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP431_10485	COG0101	tRNA pseudouridine synthase activity
NP431_10495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP431_10500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP431_10505	COG0747	negative chemotaxis
NP431_10515	COG1349	DNA-binding transcription factor activity
NP431_10530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP431_10540	COG0431	NADPH-dependent FMN reductase
NP431_10550	COG3101	peptidyl-lysine hydroxylation
NP431_10555	COG2860	membrane
NP431_10560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP431_10565	COG2890	protein-(glutamine-N5) methyltransferase activity
NP431_10570	COG2840	Smr protein MutS2
NP431_10575	COG2062	phosphohistidine phosphatase, SixA
NP431_10590	COG1024	Enoyl-CoA hydratase
NP431_10590	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP431_10595	COG0183	Belongs to the thiolase family
NP431_10615	COG2067	long-chain fatty acid transport protein
NP431_10635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP431_10640	COG1138	Cytochrome C-type biogenesis protein
NP431_10645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NP431_10650	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP431_10655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP431_10660	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP431_10665	COG4133	protoheme IX ABC transporter activity
NP431_10675	COG0835	chemotaxis
NP431_10685	COG1192	Involved in chromosome partitioning
NP431_10690	COG2201	protein-glutamate methylesterase activity
NP431_10695	COG2198	Histidine kinase
NP431_10695	COG0784	Response regulator, receiver
NP431_10695	COG0643	Histidine kinase
NP431_10700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NP431_10740	COG1987	bacterial-type flagellum assembly
NP431_10790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP431_10800	COG1677	Flagellar hook-basal body complex protein FliE
NP431_10820	COG1516	flagellar protein fliS
NP431_10830	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP431_10835	COG1334	flagellar protein FlaG
NP431_10840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP431_10845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP431_10850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP431_10855	COG2837	iron assimilation
NP431_10880	COG1393	Belongs to the ArsC family
NP431_10885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP431_10900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NP431_10905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP431_10910	COG2716	regulation of RNA biosynthetic process
NP431_10915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP431_10930	COG4783	chaperone-mediated protein folding
NP431_10935	COG1393	Belongs to the ArsC family
NP431_10955	COG2233	PERMEase
NP431_10960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP431_10965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP431_10970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NP431_10975	COG0121	glutamine amidotransferase
NP431_10980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NP431_10985	COG1960	acyl-CoA dehydrogenase activity
NP431_11005	COG0328	RNA-DNA hybrid ribonuclease activity
NP431_11010	COG2226	methyltransferase
NP431_11015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP431_11020	COG0741	lytic transglycosylase activity
NP431_11020	COG1388	LysM domain
NP431_11030	COG3021	interspecies interaction between organisms
NP431_11035	COG0347	Belongs to the P(II) protein family
NP431_11045	COG0037	tRNA processing
NP431_11050	COG0825	malonyl-CoA metabolic process
NP431_11055	COG0587	DNA-directed DNA polymerase activity
NP431_11065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP431_11070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP431_11080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NP431_11085	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
NP431_11095	COG0750	zinc metalloprotease
NP431_11100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NP431_11105	COG0575	Belongs to the CDS family
NP431_11110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP431_11115	COG0233	cytoplasmic translational termination
NP431_11120	COG0528	UMP kinase activity
NP431_11125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NP431_11130	COG0052	Belongs to the universal ribosomal protein uS2 family
NP431_11135	COG0024	Methionine aminopeptidase
NP431_11140	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NP431_11150	COG0564	pseudouridine synthase activity
NP431_11180	COG1671	Belongs to the UPF0178 family
NP431_11185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NP431_11195	COG0254	rRNA binding
NP431_11200	COG1720	tRNA m6t6A37 methyltransferase activity
NP431_11220	COG0733	neurotransmitter:sodium symporter activity
NP431_11230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP431_11235	COG0514	ATP-dependent DNA helicase (RecQ)
NP431_11240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP431_11250	COG2991	Protein conserved in bacteria
NP431_11255	COG1477	protein flavinylation
NP431_11260	COG2871	sodium ion transport
NP431_11265	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP431_11270	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP431_11275	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP431_11280	COG1805	sodium ion transport
NP431_11285	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NP431_11290	COG0271	Belongs to the BolA IbaG family
NP431_11295	COG2813	Specifically methylates the guanine in position
NP431_11320	COG1595	DNA-templated transcription, initiation
NP431_11340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP431_11345	COG0693	protein deglycase activity
NP431_11350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP431_11360	COG2166	iron-sulfur cluster assembly
NP431_11365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NP431_11370	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NP431_11380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP431_11380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NP431_11385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP431_11390	COG1074	ATP-dependent DNA helicase activity
NP431_11395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NP431_11415	COG3141	response to X-ray
NP431_11425	COG2171	N-acyltransferase activity
NP431_11430	COG0584	glycerophosphoryl diester phosphodiesterase
NP431_11435	COG2271	Major facilitator Superfamily
NP431_11440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP431_11445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP431_11450	COG1349	DNA-binding transcription factor activity
NP431_11455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP431_11480	COG1609	Transcriptional regulator
NP431_11485	COG1609	Transcriptional regulator
NP431_11490	COG0583	DNA-binding transcription factor activity
NP431_11520	COG0463	Glycosyl transferase, family 2
NP431_11570	COG4964	Belongs to the GSP D family
NP431_11595	COG2169	Transcriptional regulator
NP431_11600	COG1022	Amp-dependent synthetase and ligase
NP431_11610	COG0583	DNA-binding transcription factor activity
NP431_11615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP431_11620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP431_11630	COG0560	Phosphoserine phosphatase
NP431_11640	COG0813	purine-nucleoside phosphorylase activity
NP431_11645	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NP431_11650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NP431_11655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NP431_11660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP431_11665	COG0084	hydrolase, TatD family'
NP431_11675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NP431_11690	COG3153	acetyltransferase
NP431_11695	COG3154	lipid carrier protein
NP431_11705	COG0826	peptidase U32
NP431_11710	COG0826	peptidase U32
NP431_11715	COG0534	Mate efflux family protein
NP431_11725	COG1185	polyribonucleotide nucleotidyltransferase activity
NP431_11730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NP431_11735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP431_11740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP431_11745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NP431_11750	COG0195	Participates in both transcription termination and antitermination
NP431_11755	COG0779	Required for maturation of 30S ribosomal subunits
NP431_11770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP431_11780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP431_11785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP431_11790	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NP431_11795	COG1534	Rna-binding protein
NP431_11800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP431_11805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NP431_11810	COG2027	D-alanyl-D-alanine carboxypeptidase
NP431_11820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP431_11825	COG0739	heme binding
NP431_11835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_11840	COG0316	Belongs to the HesB IscA family
NP431_11845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP431_11850	COG0628	permease
NP431_11855	COG2813	Specifically methylates the guanine in position
NP431_11865	COG2205	protein histidine kinase activity
NP431_11865	COG0784	Response regulator, receiver
NP431_11870	COG0747	negative chemotaxis
NP431_11880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP431_11885	COG0444	Belongs to the ABC transporter superfamily
NP431_11890	COG4608	Belongs to the ABC transporter superfamily
NP431_11900	COG2971	BadF BadG BcrA BcrD
NP431_11915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP431_11920	COG3842	ATPase activity
NP431_11930	COG1840	ABC-type Fe3 transport system, periplasmic component
NP431_11935	COG0004	ammonium transporteR
NP431_11945	COG3112	Uncharacterised protein family (UPF0231)
NP431_11950	COG3835	regulator
NP431_11955	COG2610	gluconate transmembrane transporter activity
NP431_11960	COG1929	Belongs to the glycerate kinase type-1 family
NP431_11965	COG1049	propionate catabolic process, 2-methylcitrate cycle
NP431_11970	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP431_11975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP431_11980	COG1643	Atp-dependent helicase
NP431_11985	COG1489	DNA binding
NP431_11995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP431_12005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP431_12010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NP431_12015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NP431_12020	COG0842	Transport permease protein
NP431_12025	COG1131	(ABC) transporter
NP431_12030	COG0659	secondary active sulfate transmembrane transporter activity
NP431_12035	COG0288	reversible hydration of carbon dioxide
NP431_12050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP431_12055	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP431_12060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NP431_12065	COG2186	Transcriptional regulator
NP431_12075	COG0157	Belongs to the NadC ModD family
NP431_12085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP431_12090	COG1459	type II secretion system
NP431_12100	COG0237	dephospho-CoA kinase activity
NP431_12105	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NP431_12110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NP431_12125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NP431_12130	COG0228	four-way junction DNA binding
NP431_12135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NP431_12140	COG4137	Cytochrome C assembly protein
NP431_12145	COG4536	flavin adenine dinucleotide binding
NP431_12150	COG1854	S-ribosylhomocysteine lyase activity
NP431_12160	COG2918	glutathione biosynthetic process
NP431_12165	COG0612	Peptidase, M16
NP431_12170	COG1238	metal cluster binding
NP431_12180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NP431_12185	COG0511	ligase activity, forming carbon-carbon bonds
NP431_12185	COG5016	pyruvate
NP431_12190	COG3630	sodium ion export across plasma membrane
NP431_12250	COG0527	aspartate kinase activity
NP431_12255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP431_12270	COG1546	Belongs to the CinA family
NP431_12275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NP431_12290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NP431_12295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NP431_12310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NP431_12315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NP431_12320	COG0148	phosphopyruvate hydratase activity
NP431_12325	COG0504	CTP synthase activity
NP431_12330	COG3956	TIGRFAM MazG family protein
NP431_12335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP431_12340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP431_12350	COG0736	holo-[acyl-carrier-protein] synthase activity
NP431_12355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NP431_12360	COG1381	Involved in DNA repair and RecF pathway recombination
NP431_12365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP431_12380	COG0481	GTPase activity
NP431_12385	COG3086	response to oxidative stress
NP431_12400	COG1595	DNA-templated transcription, initiation
NP431_12405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP431_12415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NP431_12420	COG0354	folic acid binding
NP431_12435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP431_12440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP431_12445	COG3079	Belongs to the UPF0149 family
NP431_12450	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NP431_12460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP431_12465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NP431_12470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP431_12480	COG0583	DNA-binding transcription factor activity
NP431_12485	COG1279	arginine transmembrane transporter activity
NP431_12490	COG0668	transmembrane transport
NP431_12495	COG0191	fructose-bisphosphate aldolase activity
NP431_12500	COG0126	phosphoglycerate kinase activity
NP431_12505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP431_12510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP431_12515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP431_12530	COG2356	endonuclease I
NP431_12535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NP431_12540	COG0189	ligase activity
NP431_12545	COG1678	Uncharacterized ACR, COG1678
NP431_12550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP431_12565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP431_12570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP431_12575	COG0762	integral membrane protein
NP431_12590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP431_12595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP431_12600	COG2066	Belongs to the glutaminase family
NP431_12620	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NP431_12625	COG0741	lytic transglycosylase activity
NP431_12735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NP431_12740	COG0300	oxidoreductase activity
NP431_12755	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_12770	COG0795	lipopolysaccharide-transporting ATPase activity
NP431_12775	COG0795	lipopolysaccharide-transporting ATPase activity
NP431_12780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP431_12785	COG2927	DNA polymerase III (CHI subunit)
NP431_12790	COG0525	valine-tRNA ligase activity
NP431_12815	COG2235	arginine
NP431_12825	COG0540	Belongs to the ATCase OTCase family
NP431_12830	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NP431_12835	COG0251	oxidation-reduction process
NP431_12840	COG0204	Acyl-transferase
NP431_12845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP431_12850	COG5007	Belongs to the BolA IbaG family
NP431_12860	COG2854	intermembrane phospholipid transfer
NP431_12865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NP431_12870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NP431_12875	COG1127	ABC transporter
NP431_12885	COG0517	IMP dehydrogenase activity
NP431_12885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP431_12895	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NP431_12900	COG1137	ATPase activity
NP431_12910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP431_12915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP431_12920	COG1660	Displays ATPase and GTPase activities
NP431_12925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP431_12930	COG2239	Acts as a magnesium transporter
NP431_12935	COG0312	modulator of DNA gyrase
NP431_12940	COG3028	Belongs to the UPF0307 family
NP431_12945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP431_12950	COG0564	pseudouridine synthase activity
NP431_12960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP431_12965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP431_12970	COG0312	modulator of DNA gyrase
NP431_12975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP431_12980	COG3164	Protein of unknown function
NP431_12990	COG0424	maF-like protein
NP431_12995	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NP431_13000	COG1792	Involved in formation and maintenance of cell shape
NP431_13005	COG1077	Cell shape determining protein MreB Mrl
NP431_13040	COG2165	general secretion pathway protein
NP431_13050	COG1459	type II secretion system
NP431_13055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP431_13065	COG3267	Type II secretory pathway component ExeA
NP431_13065	COG3409	Peptidoglycan-binding domain 1 protein
NP431_13090	COG2200	EAL domain
NP431_13090	COG2199	diguanylate cyclase activity
NP431_13095	COG0629	single-stranded DNA binding
NP431_13110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP431_13120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP431_13125	COG0527	aspartate kinase activity
NP431_13130	COG0646	methionine synthase
NP431_13130	COG1410	methionine synthase
NP431_13190	COG0175	sulfate reduction
NP431_13195	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP431_13200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP431_13220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP431_13225	COG0735	belongs to the Fur family
NP431_13235	COG0166	Belongs to the GPI family
NP431_13240	COG0432	Pfam Uncharacterised protein family UPF0047
NP431_13245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP431_13270	COG2965	DNA replication, synthesis of RNA primer
NP431_13275	COG0360	Binds together with S18 to 16S ribosomal RNA
NP431_13280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP431_13285	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP431_13295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NP431_13300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NP431_13330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NP431_13340	COG0678	peroxiredoxin activity
NP431_13340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP431_13345	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP431_13345	COG0165	Argininosuccinate lyase
NP431_13350	COG0137	argininosuccinate synthase activity
NP431_13355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NP431_13360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP431_13370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NP431_13380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NP431_13385	COG0527	aspartate kinase activity
NP431_13385	COG0460	homoserine dehydrogenase
NP431_13390	COG0626	cystathionine gamma-synthase activity
NP431_13400	COG0281	malic enzyme
NP431_13420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP431_13440	COG2923	Belongs to the DsrF TusC family
NP431_13445	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NP431_13450	COG2964	Protein conserved in bacteria
NP431_13455	COG0545	Peptidyl-prolyl cis-trans isomerase
NP431_13465	COG2900	Belongs to the SlyX family
NP431_13475	COG1047	Peptidyl-prolyl cis-trans
NP431_13490	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP431_13495	COG0488	(ABC) transporter
NP431_13505	COG0429	hydrolase of the alpha beta-hydrolase fold
NP431_13510	COG3089	Belongs to the UPF0270 family
NP431_13515	COG3954	Phosphoribulokinase
NP431_13520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP431_13530	COG1012	belongs to the aldehyde dehydrogenase family
NP431_13540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP431_13545	COG0512	Glutamine amidotransferase of anthranilate synthase
NP431_13550	COG0180	Tryptophanyl-tRNA synthetase
NP431_13555	COG0546	phosphoglycolate phosphatase activity
NP431_13560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP431_13565	COG0557	exoribonuclease II activity
NP431_13570	COG1959	2 iron, 2 sulfur cluster binding
NP431_13575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP431_13575	COG1017	nitric oxide dioxygenase activity
NP431_13580	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NP431_13585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NP431_13590	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NP431_13595	COG0330	HflC and HflK could
NP431_13600	COG0330	HflC and HflK could
NP431_13605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP431_13615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NP431_13620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NP431_13625	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP431_13630	COG0802	atpase or kinase
NP431_13635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NP431_13700	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NP431_13705	COG1162	GTPase activity
NP431_13715	COG0471	metal ion transport
NP431_13725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NP431_13730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP431_13740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NP431_13745	COG1045	serine acetyltransferase
NP431_13750	COG4942	peptidase
NP431_13770	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NP431_13775	COG1053	succinate dehydrogenase
NP431_13780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP431_13800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP431_13805	COG1509	lysine 2,3-aminomutase activity
NP431_13810	COG1285	pathogenesis
NP431_13845	COG0534	Mate efflux family protein
NP431_13850	COG0205	6-phosphofructokinase activity
NP431_13860	COG3678	ATP-independent chaperone mediated protein folding
NP431_13865	COG0745	RESPONSE REGULATOR receiver
NP431_13870	COG2205	protein histidine kinase activity
NP431_13875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP431_13880	COG3030	protein affecting phage T7 exclusion by the F plasmid
NP431_13885	COG1027	Aspartate ammonia-lyase
NP431_13890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NP431_13895	COG4232	protein-disulfide reductase activity
NP431_13905	COG3263	regulation of cellular component size
NP431_13915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP431_13930	COG0784	Response regulator, receiver
NP431_13930	COG2198	Histidine kinase
NP431_13930	COG2205	protein histidine kinase activity
NP431_13935	COG2814	Major facilitator Superfamily
NP431_13950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP431_13955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP431_13960	COG0511	ligase activity, forming carbon-carbon bonds
NP431_13965	COG0439	Biotin carboxylase
NP431_13970	COG2264	protein methyltransferase activity
NP431_13975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP431_13980	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NP431_14060	COG3710	Transcriptional regulator
NP431_14070	COG0138	bifunctional purine biosynthesis protein purh
NP431_14075	COG0151	Belongs to the GarS family
NP431_14090	COG1253	flavin adenine dinucleotide binding
NP431_14095	COG3068	Protein conserved in bacteria
NP431_14105	COG1573	uracil-dna glycosylase
NP431_14110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NP431_14115	COG2816	NAD+ diphosphatase activity
NP431_14120	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NP431_14125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NP431_14130	COG0085	RNA polymerase activity
NP431_14135	COG0222	ribosome binding
NP431_14140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NP431_14155	COG0250	Participates in transcription elongation, termination and antitermination
NP431_14160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP431_14200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP431_14210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP431_14285	COG4206	TonB-dependent receptor
NP431_14305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP431_14310	COG0534	Mate efflux family protein
NP431_14315	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NP431_14320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP431_14325	COG2937	Belongs to the GPAT DAPAT family
NP431_14330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NP431_14335	COG3161	chorismate lyase activity
NP431_14340	COG1580	Controls the rotational direction of flagella during chemotaxis
NP431_14345	COG0705	Rhomboid family
NP431_14360	COG2177	Part of the ABC transporter FtsEX involved in
NP431_14365	COG2884	Cell division ATP-binding protein ftsE
NP431_14370	COG0552	protein localization to endoplasmic reticulum
NP431_14375	COG0742	ribosomal rna small subunit methyltransferase
NP431_14420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP431_14425	COG0640	Transcriptional regulator
NP431_14430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP431_14435	COG1280	lysine exporter protein (LysE YggA)
NP431_14440	COG2267	carboxylic ester hydrolase activity
NP431_14445	COG0561	phosphatase activity
NP431_14460	COG3148	PFAM DTW domain containing protein
NP431_14465	COG1011	Hydrolase
NP431_14470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NP431_14480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP431_14485	COG0019	diaminopimelate decarboxylase activity
NP431_14495	COG1965	Belongs to the frataxin family
NP431_14500	COG3072	Adenylate cyclase
NP431_14505	COG0181	hydroxymethylbilane synthase activity
NP431_14510	COG1587	Uroporphyrinogen-III synthase
NP431_14515	COG2959	enzyme of heme biosynthesis
NP431_14520	COG3071	HemY protein
NP431_14570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NP431_14585	COG3118	belongs to the thioredoxin family
NP431_14590	COG0513	Belongs to the DEAD box helicase family
NP431_14595	COG0248	Ppx GppA phosphatase
NP431_14600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NP431_14610	COG0514	ATP-dependent DNA helicase (RecQ)
NP431_14615	COG2962	Rard protein
NP431_14625	COG1280	lysine exporter protein (LysE YggA)
NP431_14630	COG0405	Gamma-glutamyltransferase
NP431_14635	COG0210	DNA helicase
NP431_14645	COG3220	belongs to the UPF0276 family
NP431_14665	COG2814	Major facilitator Superfamily
NP431_14675	COG0006	proline dipeptidase activity
NP431_14675	COG0006	proline dipeptidase activity
NP431_14685	COG2022	thiamine diphosphate biosynthetic process
NP431_14690	COG2104	thiamine diphosphate biosynthetic process
NP431_14695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP431_14705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NP431_14710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP431_14715	COG2132	Multicopper oxidase
NP431_14765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NP431_14775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP431_14780	COG0408	coproporphyrinogen oxidase activity
NP431_14785	COG0009	L-threonylcarbamoyladenylate synthase
NP431_14790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NP431_14795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NP431_14800	COG0551	DNA topoisomerase type I activity
NP431_14805	COG2922	Belongs to the Smg family
NP431_14810	COG0758	DNA mediated transformation
NP431_14830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP431_14830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP431_14835	COG0569	domain protein
NP431_14840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP431_14850	COG1272	protein, Hemolysin III
NP431_14855	COG4326	sporulation control protein
NP431_14865	COG3084	Protein conserved in bacteria
NP431_14875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP431_14880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP431_14885	COG0204	Acyl-transferase
NP431_14895	COG0606	chelatase, subunit chli
NP431_14905	COG3978	acetolactate synthase activity
NP431_14920	COG0583	DNA-binding transcription factor activity
NP431_14925	COG2814	Major facilitator Superfamily
NP431_14930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_14935	COG0765	amino acid transport
NP431_14945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP431_14950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP431_14955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP431_14960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP431_14965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP431_14980	COG0356	it plays a direct role in the translocation of protons across the membrane
NP431_14985	COG3312	ion transport
NP431_14990	COG1475	DNA binding
NP431_14995	COG1192	Involved in chromosome partitioning
NP431_15005	COG0445	tRNA wobble uridine modification
NP431_15010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP431_15020	COG0706	membrane insertase activity
NP431_15030	COG0594	ribonuclease P activity
NP431_15040	COG1126	abc transporter atp-binding protein
NP431_15055	COG1278	Cold shock
NP431_15060	COG1741	Belongs to the pirin family
NP431_15065	COG4667	esterase of the alpha-beta hydrolase superfamily
NP431_15080	COG3304	Inner membrane component domain
NP431_15085	COG0673	inositol 2-dehydrogenase activity
NP431_15090	COG2194	sulfuric ester hydrolase activity
NP431_15095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP431_15110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP431_15125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP431_15145	COG1418	mRNA catabolic process
NP431_15150	COG2239	Acts as a magnesium transporter
NP431_15155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NP431_15170	COG0531	amino acid
NP431_15175	COG1522	sequence-specific DNA binding
NP431_15200	COG0673	inositol 2-dehydrogenase activity
NP431_15220	COG3132	Protein of unknown function, DUF480
NP431_15235	COG0784	Response regulator, receiver
NP431_15235	COG2205	protein histidine kinase activity
NP431_15285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP431_15290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP431_15295	COG1280	lysine exporter protein (LysE YggA)
NP431_15305	COG0183	Belongs to the thiolase family
NP431_15325	COG3005	denitrification pathway
NP431_15335	COG0243	molybdopterin cofactor binding
NP431_15345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NP431_15350	COG3850	Histidine kinase
NP431_15355	COG2197	response regulator
NP431_15370	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP431_15390	COG0840	transmembrane signaling receptor activity
NP431_15400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP431_15410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NP431_15415	COG0840	transmembrane signaling receptor activity
NP431_15420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP431_15425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP431_15435	COG2358	TRAP transporter, solute receptor (TAXI family
NP431_15445	COG2897	thiosulfate sulfurtransferase activity
NP431_15455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP431_15475	COG0038	chloride channel
NP431_15490	COG4989	oxidoreductase activity
NP431_15495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NP431_15495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NP431_15500	COG0516	GMP reductase activity
NP431_15515	COG1073	alpha beta
NP431_15535	COG1902	pentaerythritol trinitrate reductase activity
NP431_15545	COG1073	alpha beta
NP431_15550	COG1073	alpha beta
NP431_15560	COG2207	Transcriptional regulator
NP431_15565	COG1414	Transcriptional regulator
NP431_15570	COG2267	carboxylic ester hydrolase activity
NP431_15575	COG0183	Belongs to the thiolase family
NP431_15580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP431_15585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP431_15595	COG4948	Mandelate Racemase Muconate Lactonizing
NP431_15605	COG3485	protocatechuate 3,4-dioxygenase
NP431_15630	COG2814	Major facilitator Superfamily
NP431_15635	COG0583	DNA-binding transcription factor activity
NP431_15640	COG1473	amidohydrolase
NP431_15645	COG1288	antiporter activity
NP431_15655	COG2423	ornithine cyclodeaminase activity
NP431_15660	COG1757	Na H antiporter
NP431_15670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NP431_15690	COG0579	oxidoreductase
NP431_15710	COG0583	DNA-binding transcription factor activity
NP431_15720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP431_15725	COG0667	Aldo Keto reductase
NP431_15740	COG0583	DNA-binding transcription factor activity
NP431_15745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP431_15770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP431_15775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP431_15780	COG2159	amidohydrolase
NP431_15785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NP431_15815	COG4771	TonB-dependent receptor
NP431_15820	COG0583	DNA-binding transcription factor activity
NP431_15830	COG2197	response regulator
NP431_15870	COG1132	(ABC) transporter
NP431_15885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_15910	COG2030	dehydratase
NP431_15910	COG1012	belongs to the aldehyde dehydrogenase family
NP431_15915	COG3396	Phenylacetate-CoA oxygenase
NP431_15920	COG3460	Phenylacetate-CoA oxygenase
NP431_15925	COG3396	Phenylacetate-CoA oxygenase
NP431_15930	COG2151	metal-sulfur cluster biosynthetic enzyme
NP431_15935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP431_15940	COG1024	Enoyl-CoA hydratase
NP431_15945	COG1024	Enoyl-CoA hydratase
NP431_15950	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP431_15955	COG2050	protein possibly involved in aromatic compounds catabolism
NP431_15960	COG0183	Belongs to the thiolase family
NP431_15965	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NP431_15970	COG3327	negative regulation of DNA-templated transcription, initiation
NP431_16010	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_16035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP431_16040	COG0402	S-adenosylhomocysteine deaminase activity
NP431_16045	COG0656	L-ascorbic acid biosynthetic process
NP431_16050	COG1349	DNA-binding transcription factor activity
NP431_16055	COG2084	Dehydrogenase
NP431_16060	COG3395	kinase activity
NP431_16065	COG0235	Class ii aldolase
NP431_16070	COG3622	Belongs to the hyi family
NP431_16075	COG2610	gluconate transmembrane transporter activity
NP431_16080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP431_16080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP431_16105	COG1355	regulation of microtubule-based process
NP431_16130	COG2814	Major facilitator Superfamily
NP431_16145	COG2205	protein histidine kinase activity
NP431_16145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_16210	COG3474	cytochrome
NP431_16220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NP431_16220	COG3264	Mechanosensitive ion channel
NP431_16230	COG0583	DNA-binding transcription factor activity
NP431_16255	COG4948	Mandelate Racemase Muconate Lactonizing
NP431_16290	COG4770	biotin carboxylase activity
NP431_16300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP431_16305	COG1960	acyl-CoA dehydrogenase activity
NP431_16315	COG0183	Belongs to the thiolase family
NP431_16325	COG1960	acyl-CoA dehydrogenase activity
NP431_16330	COG1024	Enoyl-CoA hydratase
NP431_16345	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_16350	COG1309	transcriptional regulator
NP431_16355	COG1012	belongs to the aldehyde dehydrogenase family
NP431_16370	COG4176	ABC-type proline glycine betaine transport system permease component
NP431_16375	COG4175	Glycine betaine
NP431_16375	COG0517	IMP dehydrogenase activity
NP431_16380	COG0330	HflC and HflK could
NP431_16390	COG5001	Diguanylate cyclase
NP431_16390	COG3300	MHYT domain
NP431_16415	COG2197	response regulator
NP431_16420	COG0515	serine threonine protein kinase
NP431_16420	COG2815	serine threonine protein kinase
NP431_16425	COG2223	nitrite transmembrane transporter activity
NP431_16435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP431_16440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP431_16440	COG1648	precorrin-2 dehydrogenase activity
NP431_16445	COG0243	molybdopterin cofactor binding
NP431_16495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NP431_16570	COG3265	gluconokinase activity
NP431_16585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NP431_16590	COG1280	lysine exporter protein (LysE YggA)
NP431_16600	COG4628	conserved protein (DUF2132)
NP431_16605	COG1278	Cold shock
NP431_16625	COG0784	Response regulator, receiver
NP431_16625	COG4191	Histidine kinase
NP431_16630	COG4657	Part of a membrane complex involved in electron transport
NP431_16635	COG2878	Part of a membrane complex involved in electron transport
NP431_16640	COG4656	Part of a membrane complex involved in electron transport
NP431_16645	COG4658	electron transport chain
NP431_16685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP431_16690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_16695	COG2814	Major facilitator Superfamily
NP431_16700	COG0583	DNA-binding transcription factor activity
NP431_16705	COG0583	DNA-binding transcription factor activity
NP431_16715	COG3711	transcriptional antiterminator
NP431_16720	COG2190	(PTS) system
NP431_16720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_16720	COG1263	PTS System
NP431_16725	COG2723	6-phospho-beta-galactosidase activity
NP431_16730	COG0579	oxidoreductase
NP431_16735	COG1027	Aspartate ammonia-lyase
NP431_16740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP431_16750	COG0506	proline dehydrogenase activity
NP431_16750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NP431_16750	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NP431_16770	COG2365	Tyrosine phosphatase family
NP431_16780	COG0583	DNA-binding transcription factor activity
NP431_16785	COG1012	belongs to the aldehyde dehydrogenase family
NP431_16810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_16815	COG1757	Na H antiporter
NP431_16830	COG3938	Belongs to the proline racemase family
NP431_16840	COG1757	Na H antiporter
NP431_16845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP431_16850	COG1012	belongs to the aldehyde dehydrogenase family
NP431_16855	COG2814	Major facilitator Superfamily
NP431_16860	COG0697	spore germination
NP431_16865	COG2207	Transcriptional regulator
NP431_16870	COG1522	sequence-specific DNA binding
NP431_16875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP431_16890	COG0697	spore germination
NP431_16905	COG0582	viral genome integration into host DNA
NP431_16945	COG5001	Diguanylate cyclase
NP431_16950	COG1869	D-ribose catabolic process
NP431_16955	COG1129	ABC transporter
NP431_16960	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP431_16965	COG1879	ABC-type sugar transport system periplasmic component
NP431_16970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP431_16975	COG1609	Transcriptional regulator
NP431_16980	COG0789	Transcriptional regulator
NP431_16995	COG1289	transmembrane transporter activity
NP431_17000	COG0210	DNA helicase
NP431_17005	COG1803	Methylglyoxal synthase
NP431_17010	COG1879	ABC-type sugar transport system periplasmic component
NP431_17015	COG0784	Response regulator, receiver
NP431_17015	COG2205	protein histidine kinase activity
NP431_17015	COG2198	Histidine kinase
NP431_17035	COG3119	arylsulfatase activity
NP431_17040	COG0641	radical SAM
NP431_17045	COG0714	Associated with various cellular activities
NP431_17080	COG1597	lipid kinase activity
NP431_17090	COG2223	nitrite transmembrane transporter activity
NP431_17100	COG0501	Belongs to the peptidase M48B family
NP431_17105	COG1704	LemA family
NP431_17110	COG3069	C4-dicarboxylate transmembrane transporter activity
NP431_17120	COG0456	acetyltransferase
NP431_17120	COG1214	PFAM Peptidase M22, glycoprotease
NP431_17130	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP431_17135	COG2205	protein histidine kinase activity
NP431_17135	COG0784	Response regulator, receiver
NP431_17140	COG5001	Diguanylate cyclase
NP431_17140	COG3300	MHYT domain
NP431_17150	COG3706	GGDEF domain
NP431_17160	COG2197	response regulator
NP431_17205	COG0471	metal ion transport
NP431_17215	COG3290	protein histidine kinase activity
NP431_17230	COG0069	glutamate synthase activity
NP431_17235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NP431_17270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NP431_17290	COG4670	ketone body catabolic process
NP431_17295	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_17300	COG1737	Transcriptional regulator
NP431_17310	COG0765	amino acid transport
NP431_17315	COG0765	amino acid transport
NP431_17325	COG4166	transmembrane transport
NP431_17330	COG0601	transmembrane transport
NP431_17335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP431_17340	COG4172	Belongs to the ABC transporter superfamily
NP431_17345	COG2366	antibiotic biosynthetic process
NP431_17360	COG2205	protein histidine kinase activity
NP431_17365	COG0745	RESPONSE REGULATOR receiver
NP431_17375	COG1846	Transcriptional regulator
NP431_17380	COG2130	NADP-dependent
NP431_17385	COG0420	3'-5' exonuclease activity
NP431_17390	COG0419	ATPase involved in DNA repair
NP431_17410	COG1733	regulation of RNA biosynthetic process
NP431_17435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP431_17455	COG0251	oxidation-reduction process
NP431_17465	COG3040	lipid binding
NP431_17480	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NP431_17495	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NP431_17505	COG0583	DNA-binding transcription factor activity
NP431_17510	COG0277	FAD linked oxidase domain protein
NP431_17555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP431_17555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NP431_17575	COG5001	Diguanylate cyclase
NP431_17580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP431_17585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP431_17595	COG2116	formate transmembrane transporter activity
NP431_17615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NP431_17640	COG3118	belongs to the thioredoxin family
NP431_17645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP431_17665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP431_17670	COG0583	DNA-binding transcription factor activity
NP431_17720	COG1328	CTP reductase activity
NP431_17725	COG0602	queuosine metabolic process
NP431_17730	COG0534	Mate efflux family protein
NP431_17735	COG2207	Transcriptional regulator
NP431_17745	COG4067	protein conserved in archaea
NP431_17745	COG0189	ligase activity
NP431_17755	COG1492	cobalamin metabolic process
NP431_17760	COG0725	ABC transporter, periplasmic molybdate-binding protein
NP431_17765	COG4149	molybdate abc transporter
NP431_17770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NP431_17780	COG2203	Gaf domain
NP431_17780	COG3706	GGDEF domain
NP431_17780	COG4251	negative regulation of phosphorylation
NP431_17780	COG5001	Diguanylate cyclase
NP431_17785	COG3706	GGDEF domain
NP431_17800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NP431_17805	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NP431_17815	COG0745	RESPONSE REGULATOR receiver
NP431_17830	COG3140	Belongs to the UPF0181 family
NP431_17855	COG0023	Translation Initiation Factor
NP431_17865	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP431_17875	COG0045	succinate-CoA ligase (ADP-forming) activity
NP431_17875	COG1042	CoA-binding domain protein
NP431_17875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP431_17880	COG0583	DNA-binding transcription factor activity
NP431_17890	COG3447	MASE1 domain protein
NP431_17890	COG5001	Diguanylate cyclase
NP431_17890	COG5002	protein histidine kinase activity
NP431_17895	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP431_17900	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP431_17905	COG1984	allophanate hydrolase subunit 2
NP431_17915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NP431_17920	COG4181	ATPase activity
NP431_17930	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP431_17935	COG3300	MHYT domain
NP431_17935	COG5001	Diguanylate cyclase
NP431_17960	COG1324	tolerance protein
NP431_17980	COG2050	protein possibly involved in aromatic compounds catabolism
NP431_17995	COG2067	long-chain fatty acid transport protein
NP431_18000	COG2267	carboxylic ester hydrolase activity
NP431_18020	COG0737	Belongs to the 5'-nucleotidase family
NP431_18025	COG3593	DNA synthesis involved in DNA repair
NP431_18035	COG0583	DNA-binding transcription factor activity
NP431_18040	COG2116	formate transmembrane transporter activity
NP431_18045	COG2353	YceI-like domain
NP431_18050	COG3038	cytochrome b561
NP431_18065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NP431_18070	COG0513	Belongs to the DEAD box helicase family
NP431_18075	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NP431_18080	COG0840	transmembrane signaling receptor activity
NP431_18090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP431_18105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP431_18110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NP431_18115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP431_18125	COG2207	Transcriptional regulator
NP431_18130	COG1979	alcohol dehydrogenase
NP431_18140	COG1126	abc transporter atp-binding protein
NP431_18145	COG0765	amino acid transport
NP431_18150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_18155	COG0765	amino acid transport
NP431_18170	COG1609	Transcriptional regulator
NP431_18175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP431_18175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP431_18180	COG1105	Belongs to the carbohydrate kinase PfkB family
NP431_18185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP431_18185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP431_18185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NP431_18200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_18210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP431_18220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP431_18225	COG0509	glycine decarboxylation via glycine cleavage system
NP431_18280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP431_18285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_18295	COG0814	amino acid
NP431_18325	COG0443	Heat shock 70 kDa protein
NP431_18365	COG1349	DNA-binding transcription factor activity
NP431_18370	COG0673	inositol 2-dehydrogenase activity
NP431_18375	COG4702	Belongs to the UPF0303 family
NP431_18390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP431_18395	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP431_18395	COG0022	dehydrogenase e1 component
NP431_18410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP431_18410	COG0574	Belongs to the PEP-utilizing enzyme family
NP431_18415	COG0543	2 iron, 2 sulfur cluster binding
NP431_18425	COG3383	formate dehydrogenase (NAD+) activity
NP431_18450	COG3604	Transcriptional regulator
NP431_18460	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP431_18470	COG1609	Transcriptional regulator
NP431_18475	COG4974	Belongs to the 'phage' integrase family
NP431_18495	COG0583	DNA-binding transcription factor activity
NP431_18500	COG0657	acetylesterase activity
NP431_18505	COG0583	DNA-binding transcription factor activity
NP431_18510	COG0583	DNA-binding transcription factor activity
NP431_18530	COG0583	DNA-binding transcription factor activity
NP431_18535	COG3949	Membrane
NP431_18540	COG1404	Belongs to the peptidase S8 family
NP431_18555	COG0583	DNA-binding transcription factor activity
NP431_18565	COG1115	amino acid carrier protein
NP431_18570	COG4160	amino acid transport
NP431_18575	COG4215	(ABC) transporter
NP431_18580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_18585	COG1126	abc transporter atp-binding protein
NP431_18605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NP431_18620	COG2040	homocysteine
NP431_18625	COG0531	amino acid
NP431_18635	COG1902	pentaerythritol trinitrate reductase activity
NP431_18650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP431_18660	COG1012	belongs to the aldehyde dehydrogenase family
NP431_18675	COG0109	protoheme IX farnesyltransferase activity
NP431_18680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP431_18685	COG1845	cytochrome c oxidase, subunit III
NP431_18690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP431_18695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP431_18700	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_18710	COG1024	Enoyl-CoA hydratase
NP431_18715	COG1024	Enoyl-CoA hydratase
NP431_18720	COG1960	acyl-CoA dehydrogenase activity
NP431_18730	COG0183	Belongs to the thiolase family
NP431_18740	COG1960	acyl-CoA dehydrogenase activity
NP431_18745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP431_18760	COG5413	integral membrane protein
NP431_18775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP431_18785	COG0513	Belongs to the DEAD box helicase family
NP431_18790	COG1454	alcohol dehydrogenase
NP431_18795	COG0235	Class ii aldolase
NP431_18800	COG1070	Carbohydrate kinase
NP431_18805	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
NP431_18810	COG1349	DNA-binding transcription factor activity
NP431_18815	COG1320	monovalent cation:proton antiporter activity
NP431_18820	COG2212	antiporter activity
NP431_18825	COG1863	multisubunit Na H antiporter MnhE subunit
NP431_18830	COG0651	ATP synthesis coupled electron transport
NP431_18835	COG1006	Multisubunit Na H antiporter MnhC subunit
NP431_18840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP431_18840	COG2111	Na H antiporter
NP431_18845	COG0589	response to stress
NP431_18850	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
NP431_18875	COG0582	viral genome integration into host DNA
NP431_18880	COG0582	viral genome integration into host DNA
NP431_18925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP431_18930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP431_18950	COG2124	cytochrome p450
NP431_19015	COG1082	Xylose isomerase domain protein TIM barrel
NP431_19025	COG1309	transcriptional regulator
NP431_19030	COG0492	ferredoxin-NADP+ reductase activity
NP431_19035	COG3118	belongs to the thioredoxin family
NP431_19040	COG3118	belongs to the thioredoxin family
NP431_19050	COG2814	Major facilitator Superfamily
NP431_19055	COG0640	Transcriptional regulator
NP431_19060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP431_19065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP431_19075	COG0549	Belongs to the carbamate kinase family
NP431_19080	COG1304	FMN binding
NP431_19085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NP431_19100	COG2807	transmembrane transport
NP431_19105	COG0583	DNA-binding transcription factor activity
NP431_19125	COG5002	protein histidine kinase activity
NP431_19130	COG0590	tRNA wobble adenosine to inosine editing
NP431_19135	COG1953	Uracil, thiamine, allantoin
NP431_19170	COG0628	permease
NP431_19175	COG2963	transposase activity
NP431_19190	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NP431_19205	COG3264	Mechanosensitive ion channel
NP431_19205	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NP431_19220	COG1127	ABC transporter
NP431_19225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NP431_19265	COG0730	response to heat
NP431_19275	COG1414	Transcriptional regulator
NP431_19285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP431_19285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP431_19290	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NP431_19295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP431_19300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_19315	COG2855	membrane
NP431_19335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP431_19345	COG1070	Carbohydrate kinase
NP431_19380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NP431_19395	COG2207	Transcriptional regulator
NP431_19410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP431_19415	COG1064	alcohol dehydrogenase
NP431_19425	COG1760	l-serine dehydratase
NP431_19440	COG0446	pyridine nucleotide-disulphide oxidoreductase
NP431_19440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP431_19455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP431_19460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP431_19470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP431_19490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP431_19495	COG1012	belongs to the aldehyde dehydrogenase family
NP431_19575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP431_19580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP431_19580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP431_19590	COG0356	it plays a direct role in the translocation of protons across the membrane
NP431_19605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP431_19610	COG0656	L-ascorbic acid biosynthetic process
NP431_19620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP431_19630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NP431_19635	COG2181	nitrate reductase activity
NP431_19635	COG0247	lactate metabolic process
NP431_19640	COG1902	pentaerythritol trinitrate reductase activity
NP431_19640	COG0446	pyridine nucleotide-disulphide oxidoreductase
NP431_19665	COG1454	alcohol dehydrogenase
NP431_19670	COG0837	glucose binding
NP431_19685	COG1119	ATPase activity
NP431_19690	COG2200	EAL domain
NP431_19705	COG0513	Belongs to the DEAD box helicase family
NP431_19710	COG0523	cobalamin synthesis protein
NP431_19715	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NP431_19725	COG0133	tryptophan synthase activity
NP431_19730	COG3530	Putative quorum-sensing-regulated virulence factor
NP431_19755	COG3186	Phenylalanine-4-hydroxylase
NP431_19760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP431_19765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP431_19785	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NP431_19790	COG1454	alcohol dehydrogenase
NP431_19795	COG2133	pyrroloquinoline quinone binding
NP431_19805	COG0783	Belongs to the Dps family
NP431_19820	COG1136	(ABC) transporter
NP431_19820	COG0577	efflux transmembrane transporter activity
NP431_19845	COG1278	Cold shock
NP431_19875	COG0545	Peptidyl-prolyl cis-trans isomerase
NP431_19880	COG0109	protoheme IX farnesyltransferase activity
NP431_19885	COG1612	heme a metabolic process
NP431_19910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NP431_19925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP431_19930	COG1280	lysine exporter protein (LysE YggA)
NP431_19950	COG0179	Fumarylacetoacetate (FAA) hydrolase
NP431_19975	COG0583	DNA-binding transcription factor activity
NP431_19980	COG5001	Diguanylate cyclase
NP431_19985	COG0739	heme binding
NP431_20005	COG3314	Sporulation integral membrane protein YlbJ
NP431_20020	COG0814	amino acid
NP431_20040	COG0747	negative chemotaxis
NP431_20055	COG0798	PFAM Bile acid sodium symporter
NP431_20070	COG1131	(ABC) transporter
NP431_20075	COG0842	Transport permease protein
NP431_20085	COG3383	formate dehydrogenase (NAD+) activity
NP431_20105	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP431_20115	COG2871	sodium ion transport
NP431_20135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP431_20140	COG2067	long-chain fatty acid transport protein
NP431_20145	COG0589	response to stress
NP431_20150	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP431_20165	COG1472	Belongs to the glycosyl hydrolase 3 family
NP431_20175	COG0366	Alpha amylase catalytic
NP431_20180	COG1979	alcohol dehydrogenase
NP431_20195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP431_20205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP431_20215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NP431_20240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP431_20250	COG4948	Mandelate Racemase Muconate Lactonizing
NP431_20255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP431_20270	COG1902	pentaerythritol trinitrate reductase activity
NP431_20275	COG0583	DNA-binding transcription factor activity
NP431_20280	COG1063	alcohol dehydrogenase
NP431_20295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP431_20315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP431_20320	COG0835	chemotaxis
NP431_20320	COG0784	Response regulator, receiver
NP431_20325	COG0748	coenzyme F420 binding
NP431_20360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP431_20365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP431_20370	COG3217	Mosc domain protein beta barrel domain protein
NP431_20370	COG0633	Ferredoxin
NP431_20370	COG3217	Mosc domain protein beta barrel domain protein
NP431_20370	COG0633	Ferredoxin
NP431_20380	COG0418	dihydroorotase activity
NP431_20385	COG2354	Protein conserved in bacteria
NP431_20395	COG2176	DNA-directed DNA polymerase activity
NP431_20410	COG1132	(ABC) transporter
NP431_20420	COG1073	alpha beta
NP431_20425	COG1073	alpha beta
NP431_20450	COG2199	diguanylate cyclase activity
NP431_20455	COG0071	Belongs to the small heat shock protein (HSP20) family
NP431_20475	COG1984	allophanate hydrolase subunit 2
NP431_20480	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP431_20485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP431_20515	COG1448	Aminotransferase
NP431_20525	COG1522	sequence-specific DNA binding
NP431_20530	COG0673	inositol 2-dehydrogenase activity
NP431_20545	COG1073	alpha beta
NP431_20545	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NP431_20545	COG3064	Membrane
NP431_20555	COG0741	lytic transglycosylase activity
NP431_20590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP431_20595	COG3437	response regulator, receiver
NP431_20600	COG2205	protein histidine kinase activity
NP431_20600	COG3850	Histidine kinase
NP431_20600	COG3437	response regulator, receiver
NP431_20600	COG4999	Histidine kinase
NP431_20615	COG3833	ABC-type maltose transport systems, permease component
NP431_20620	COG1175	transmembrane transport
NP431_20630	COG3842	ATPase activity
NP431_20635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP431_20650	COG3206	protein involved in exopolysaccharide biosynthesis
NP431_20650	COG0489	protein tyrosine kinase activity
NP431_20660	COG0438	transferase activity, transferring glycosyl groups
NP431_20690	COG3097	Belongs to the UPF0267 family
NP431_20695	COG1309	transcriptional regulator
NP431_20700	COG2130	NADP-dependent
NP431_20710	COG2084	Dehydrogenase
NP431_20715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP431_20720	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
NP431_20730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_20735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP431_20745	COG1012	belongs to the aldehyde dehydrogenase family
NP431_20760	COG0583	DNA-binding transcription factor activity
NP431_20765	COG1132	(ABC) transporter
NP431_20770	COG4774	siderophore transport
NP431_20775	COG1120	ATPase activity
NP431_20780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP431_20795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_20825	COG0714	Associated with various cellular activities
NP431_20845	COG2304	oxidoreductase activity
NP431_20855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP431_20860	COG0581	inorganic phosphate transmembrane transporter activity
NP431_20865	COG0573	inorganic phosphate transmembrane transporter activity
NP431_20875	COG0840	transmembrane signaling receptor activity
NP431_20880	COG0513	Belongs to the DEAD box helicase family
NP431_20890	COG1376	ErfK ybiS ycfS ynhG family protein
NP431_20890	COG1388	LysM domain
NP431_20895	COG0415	Belongs to the DNA photolyase family
NP431_20900	COG0789	Transcriptional regulator
NP431_20905	COG3272	Protein of unknown function (DUF1722)
NP431_20910	COG0813	purine-nucleoside phosphorylase activity
NP431_20925	COG3706	GGDEF domain
NP431_20935	COG1566	PFAM secretion protein HlyD family protein
NP431_20940	COG4720	Psort location CytoplasmicMembrane, score
NP431_20950	COG0348	domain, Protein
NP431_20955	COG0437	4 iron, 4 sulfur cluster binding
NP431_20960	COG1247	-acetyltransferase
NP431_20980	COG1067	ATP-dependent peptidase activity
NP431_20990	COG1505	serine-type exopeptidase activity
NP431_20995	COG0583	DNA-binding transcription factor activity
NP431_21000	COG1620	l-lactate permease
NP431_21005	COG1304	FMN binding
NP431_21015	COG0668	transmembrane transport
NP431_21020	COG3338	carbonate dehydratase activity
NP431_21030	COG1278	Cold shock
NP431_21040	COG1063	alcohol dehydrogenase
NP431_21045	COG0156	8-amino-7-oxononanoate synthase activity
NP431_21050	COG3300	MHYT domain
NP431_21050	COG5001	Diguanylate cyclase
NP431_21075	COG0745	RESPONSE REGULATOR receiver
NP431_21095	COG0346	lactoylglutathione lyase activity
NP431_21110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP431_21145	COG1566	PFAM secretion protein HlyD family protein
NP431_21155	COG0628	permease
NP431_21160	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NP431_21165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP431_21175	COG4628	conserved protein (DUF2132)
NP431_21180	COG1686	Belongs to the peptidase S11 family
NP431_21195	COG1054	Belongs to the UPF0176 family
NP431_21200	COG4667	esterase of the alpha-beta hydrolase superfamily
NP431_21205	COG2095	MarC family integral membrane protein
NP431_21220	COG1301	dicarboxylic acid transport
NP431_21225	COG3339	Conserved Protein
NP431_21235	COG0700	Nucleoside recognition
NP431_21240	COG3366	ferrous iron transmembrane transporter activity
NP431_21245	COG0366	Alpha amylase catalytic
NP431_21250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP431_21255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NP431_21260	COG1640	4-alpha-glucanotransferase
NP431_21265	COG0058	SHG alpha-glucan phosphorylase activity
NP431_21270	COG2909	trisaccharide binding
NP431_21285	COG1999	signal sequence binding
NP431_21290	COG1263	PTS System
NP431_21290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_21295	COG1162	GTPase activity
NP431_21300	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NP431_21305	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NP431_21320	COG0366	Alpha amylase catalytic
NP431_21350	COG1263	PTS System
NP431_21350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_21360	COG2814	Major facilitator Superfamily
NP431_21365	COG4771	TonB-dependent receptor
NP431_21370	COG0583	DNA-binding transcription factor activity
NP431_21375	COG4607	ABC-type enterochelin transport system periplasmic component
NP431_21380	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP431_21385	COG4605	iron ion homeostasis
NP431_21390	COG4604	ABC transporter, ATP-binding protein
NP431_21415	COG0814	amino acid
NP431_21430	COG3171	Protein conserved in bacteria
NP431_21450	COG0583	DNA-binding transcription factor activity
NP431_21480	COG0583	DNA-binding transcription factor activity
NP431_21485	COG0662	Cupin 2, conserved barrel domain protein
NP431_21505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_21510	COG0251	oxidation-reduction process
NP431_21515	COG2423	ornithine cyclodeaminase activity
NP431_21520	COG2207	Transcriptional regulator
NP431_21550	COG1621	beta-fructofuranosidase activity
NP431_21570	COG0612	Peptidase, M16
NP431_21575	COG5492	domain, Protein
NP431_21580	COG5426	von Willebrand factor, type A
NP431_21590	COG1085	galactose-1-phosphate uridylyltransferase
NP431_21595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP431_21600	COG0659	secondary active sulfate transmembrane transporter activity
NP431_21610	COG1940	carbohydrate kinase activity
NP431_21625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP431_21635	COG0747	negative chemotaxis
NP431_21645	COG0641	radical SAM
NP431_21650	COG3119	arylsulfatase activity
NP431_21655	COG3119	arylsulfatase activity
NP431_21660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP431_21665	COG4772	TonB-dependent receptor
NP431_21675	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP431_21680	COG1129	ABC transporter
NP431_21685	COG1879	ABC-type sugar transport system periplasmic component
NP431_21690	COG1069	ribulokinase activity
NP431_21700	COG2160	L-arabinose isomerase activity
NP431_21710	COG2017	converts alpha-aldose to the beta-anomer
NP431_21715	COG3940	Belongs to the glycosyl hydrolase 43 family
NP431_21720	COG2211	Major facilitator Superfamily
NP431_21730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP431_21735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NP431_21740	COG4521	taurine ABC transporter
NP431_21745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP431_21750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP431_21760	COG4221	oxidoreductase activity
NP431_21765	COG1136	(ABC) transporter
NP431_21770	COG0577	efflux transmembrane transporter activity
NP431_21785	COG1764	response to oxidative stress
NP431_21790	COG1846	Transcriptional regulator
NP431_21800	COG3634	alkyl hydroperoxide reductase activity
NP431_21805	COG3119	arylsulfatase activity
NP431_21835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP431_21860	COG0259	pyridoxamine-phosphate oxidase activity
NP431_21915	COG1444	tRNA N-acetyltransferase activity
NP431_21940	COG4608	Belongs to the ABC transporter superfamily
NP431_21945	COG0444	Belongs to the ABC transporter superfamily
NP431_21970	COG1136	(ABC) transporter
NP431_21975	COG4591	ABC-type transport system involved in lipoprotein release permease component
NP431_21990	COG3275	phosphorelay sensor kinase activity
NP431_21995	COG3279	Response regulator of the LytR AlgR family
NP431_22000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP431_22010	COG0786	glutamate:sodium symporter activity
NP431_22020	COG1131	(ABC) transporter
NP431_22035	COG0363	glucosamine-6-phosphate deaminase activity
NP431_22055	COG1741	Belongs to the pirin family
NP431_22060	COG2259	Doxx family
NP431_22070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP431_22075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP431_22080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP431_22115	COG3123	guanosine phosphorylase activity
NP431_22125	COG5001	Diguanylate cyclase
NP431_22130	COG0534	Mate efflux family protein
NP431_22135	COG2815	serine threonine protein kinase
NP431_22135	COG0515	serine threonine protein kinase
NP431_22140	COG0564	pseudouridine synthase activity
NP431_22145	COG0561	phosphatase activity
NP431_22150	COG2199	diguanylate cyclase activity
NP431_22165	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NP431_22180	COG0583	DNA-binding transcription factor activity
NP431_22185	COG1414	Transcriptional regulator
NP431_22190	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_22205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP431_22210	COG0800	Aldolase
NP431_22215	COG2375	cellular response to nickel ion
NP431_22240	COG3047	cAMP biosynthetic process
NP431_22255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NP431_22290	COG3835	regulator
NP431_22300	COG1929	Belongs to the glycerate kinase type-1 family
NP431_22315	COG3005	denitrification pathway
NP431_22320	COG0243	molybdopterin cofactor binding
NP431_22340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP431_22345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP431_22350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP431_22355	COG1116	anion transmembrane transporter activity
NP431_22360	COG0351	phosphomethylpyrimidine kinase
NP431_22365	COG0312	modulator of DNA gyrase
NP431_22370	COG0312	modulator of DNA gyrase
NP431_22375	COG1901	pseudouridine methyltransferase
NP431_22440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP431_22450	COG0584	glycerophosphoryl diester phosphodiesterase
NP431_22455	COG0039	L-malate dehydrogenase activity
NP431_22460	COG0745	RESPONSE REGULATOR receiver
NP431_22465	COG2205	protein histidine kinase activity
NP431_22480	COG0811	peptide transport
NP431_22485	COG0811	peptide transport
NP431_22490	COG0848	biopolymer transport protein
NP431_22510	COG1770	oligopeptidase
NP431_22515	COG2814	Major facilitator Superfamily
NP431_22520	COG0010	Belongs to the arginase family
NP431_22525	COG1166	arginine decarboxylase activity
NP431_22535	COG4067	protein conserved in archaea
NP431_22535	COG0189	ligase activity
NP431_22540	COG0189	ligase activity
NP431_22555	COG3706	GGDEF domain
NP431_22570	COG0579	oxidoreductase
NP431_22585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP431_22615	COG3706	GGDEF domain
NP431_22620	COG3046	protein related to deoxyribodipyrimidine photolyase
NP431_22635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP431_22635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP431_22640	COG1765	OsmC-like protein
NP431_22650	COG3152	Membrane
NP431_22690	COG1011	Hydrolase
NP431_22705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP431_22710	COG1136	(ABC) transporter
NP431_22710	COG0577	efflux transmembrane transporter activity
NP431_22715	COG1538	Outer membrane efflux protein
NP431_22720	COG3240	lipase activity
NP431_22740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP431_22750	COG1840	ABC-type Fe3 transport system, periplasmic component
NP431_22755	COG0456	acetyltransferase
NP431_22755	COG1846	Transcriptional regulator
NP431_22760	COG3842	ATPase activity
NP431_22780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP431_22785	COG2866	Carboxypeptidase
NP431_22800	COG1760	l-serine dehydratase
NP431_22820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP431_22835	COG1304	FMN binding
NP431_22860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP431_22865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NP431_22870	COG0459	protein refolding
NP431_22875	COG1280	lysine exporter protein (LysE YggA)
NP431_22895	COG4303	Ethanolamine ammonia lyase large subunit
NP431_22900	COG4302	ethanolamine ammonia-lyase activity
NP431_22905	COG0531	amino acid
NP431_22920	COG1335	isochorismatase
NP431_22930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NP431_22945	COG0697	spore germination
NP431_22950	COG0583	DNA-binding transcription factor activity
NP431_22955	COG3015	lipoprotein NlpE involved in copper resistance
NP431_22960	COG1342	Belongs to the UPF0251 family
NP431_23015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP431_23040	COG3842	ATPase activity
NP431_23070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP431_23100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NP431_23105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP431_23120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP431_23120	COG0574	Belongs to the PEP-utilizing enzyme family
NP431_23125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NP431_23130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NP431_23135	COG0583	DNA-binding transcription factor activity
NP431_23140	COG0659	secondary active sulfate transmembrane transporter activity
NP431_23145	COG0318	PFAM AMP-dependent synthetase and ligase
NP431_23150	COG4191	Histidine kinase
NP431_23155	COG4566	intracellular signal transduction
NP431_23160	COG2814	Major facilitator Superfamily
NP431_23165	COG0583	DNA-binding transcription factor activity
NP431_23175	COG0697	spore germination
NP431_23190	COG0557	exoribonuclease II activity
NP431_23195	COG1278	Cold shock
NP431_23215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP431_23225	COG2233	PERMEase
NP431_23260	COG1309	transcriptional regulator
NP431_23290	COG2986	histidine ammonia-lyase
NP431_23295	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NP431_23300	COG3122	Protein conserved in bacteria
NP431_23305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP431_23310	COG1012	belongs to the aldehyde dehydrogenase family
NP431_23315	COG1522	sequence-specific DNA binding
NP431_23320	COG3608	succinylglutamate desuccinylase aspartoacylase
NP431_23325	COG0006	proline dipeptidase activity
NP431_23330	COG1609	Transcriptional regulator
NP431_23335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP431_23340	COG2723	6-phospho-beta-galactosidase activity
NP431_23345	COG1263	PTS System
NP431_23345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP431_23345	COG2190	(PTS) system
NP431_23350	COG2723	6-phospho-beta-galactosidase activity
NP431_23360	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_23375	COG0583	DNA-binding transcription factor activity
NP431_23385	COG0513	Belongs to the DEAD box helicase family
NP431_23420	COG1028	Short-chain dehydrogenase reductase Sdr
NP431_23425	COG0625	glutathione transferase activity
NP431_23440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism