locus-tag	class	description
OFO16_00010	COG0592	DNA-directed DNA polymerase activity
OFO16_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OFO16_00020	COG0187	DNA topoisomerase II activity
OFO16_00025	COG0071	Belongs to the small heat shock protein (HSP20) family
OFO16_00030	COG3977	Valine--pyruvate aminotransferase
OFO16_00035	COG0366	Alpha amylase catalytic
OFO16_00040	COG0751	glycine-tRNA ligase activity
OFO16_00050	COG2119	membrane
OFO16_00060	COG0425	Belongs to the sulfur carrier protein TusA family
OFO16_00075	COG0604	alcohol dehydrogenase
OFO16_00080	COG0183	Belongs to the thiolase family
OFO16_00085	COG1024	Enoyl-CoA hydratase
OFO16_00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
OFO16_00090	COG1739	Uncharacterized protein family UPF0029
OFO16_00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFO16_00135	COG1263	PTS System
OFO16_00135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_00140	COG2205	protein histidine kinase activity
OFO16_00150	COG0583	DNA-binding transcription factor activity
OFO16_00155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OFO16_00160	COG2960	long-chain fatty acid transporting porin activity
OFO16_00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_00175	COG1309	transcriptional regulator
OFO16_00225	COG4166	transmembrane transport
OFO16_00230	COG0601	transmembrane transport
OFO16_00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_00245	COG1609	Transcriptional regulator
OFO16_00250	COG0129	dihydroxy-acid dehydratase activity
OFO16_00255	COG3265	gluconokinase activity
OFO16_00260	COG2610	gluconate transmembrane transporter activity
OFO16_00265	COG0800	Aldolase
OFO16_00285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFO16_00290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OFO16_00300	COG1522	sequence-specific DNA binding
OFO16_00305	COG0742	ribosomal rna small subunit methyltransferase
OFO16_00320	COG0589	response to stress
OFO16_00325	COG1528	Iron-storage protein
OFO16_00335	COG2081	HI0933 family
OFO16_00350	COG1322	Protein conserved in bacteria
OFO16_00355	COG2226	methyltransferase
OFO16_00360	COG3165	ubiquinone biosynthetic process from chorismate
OFO16_00365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OFO16_00375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OFO16_00380	COG0805	protein transport
OFO16_00385	COG3263	regulation of cellular component size
OFO16_00390	COG0084	hydrolase, TatD family'
OFO16_00405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFO16_00405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFO16_00410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OFO16_00440	COG3385	transposase activity
OFO16_00445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OFO16_00450	COG2204	response regulator
OFO16_00455	COG3852	Histidine kinase
OFO16_00470	COG0174	glutamine synthetase
OFO16_00475	COG1217	gtp-binding protein TYPA
OFO16_00490	COG1295	ribonuclease BN
OFO16_00495	COG1490	D-aminoacyl-tRNA deacylase activity
OFO16_00500	COG0456	acetyltransferase
OFO16_00510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OFO16_00515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OFO16_00520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OFO16_00525	COG3031	protein transport across the cell outer membrane
OFO16_00535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFO16_00540	COG1459	type II secretion system
OFO16_00545	COG2165	general secretion pathway protein
OFO16_00550	COG2165	general secretion pathway protein
OFO16_00555	COG2165	general secretion pathway protein
OFO16_00560	COG4795	General secretion pathway protein
OFO16_00565	COG3156	type II secretion system protein K
OFO16_00570	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
OFO16_00575	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
OFO16_00585	COG1218	3'(2'),5'-bisphosphate nucleotidase
OFO16_00590	COG0494	nUDIX hydrolase
OFO16_00600	COG1040	competence protein
OFO16_00605	COG0596	Alpha beta hydrolase
OFO16_00615	COG2183	response to ionizing radiation
OFO16_00625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_00645	COG2233	PERMEase
OFO16_00650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OFO16_00655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFO16_00660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OFO16_00665	COG1758	RNA polymerase activity
OFO16_00670	COG0194	GDP metabolic process
OFO16_00685	COG0848	biopolymer transport protein
OFO16_00690	COG0811	peptide transport
OFO16_00710	COG4174	ABC transporter (Permease)
OFO16_00715	COG4239	(ABC) transporter, permease
OFO16_00720	COG0747	negative chemotaxis
OFO16_00725	COG0444	Belongs to the ABC transporter superfamily
OFO16_00730	COG4608	Belongs to the ABC transporter superfamily
OFO16_00745	COG3033	Beta-eliminating lyase
OFO16_00785	COG1561	YicC-like family, N-terminal region
OFO16_00790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OFO16_00795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OFO16_00800	COG1560	Kdo2-lipid A biosynthetic process
OFO16_00805	COG1309	transcriptional regulator
OFO16_00810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OFO16_00815	COG2003	Belongs to the UPF0758 family
OFO16_00835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OFO16_00840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OFO16_00845	COG0438	transferase activity, transferring glycosyl groups
OFO16_00850	COG0859	PFAM glycosyl transferase family 9
OFO16_00860	COG0438	transferase activity, transferring glycosyl groups
OFO16_00865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OFO16_00870	COG3642	lipopolysaccharide core region biosynthetic process
OFO16_00910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OFO16_00915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OFO16_00930	COG1519	Transferase
OFO16_00935	COG0859	PFAM glycosyl transferase family 9
OFO16_00940	COG1560	Kdo2-lipid A biosynthetic process
OFO16_00950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_00995	COG0175	sulfate reduction
OFO16_01000	COG3273	potassium ion transport
OFO16_01000	COG0471	metal ion transport
OFO16_01005	COG0529	Catalyzes the synthesis of activated sulfate
OFO16_01010	COG2895	sulfate adenylyltransferase (ATP) activity
OFO16_01030	COG0438	transferase activity, transferring glycosyl groups
OFO16_01040	COG1216	Glycosyl transferase, family 2
OFO16_01050	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OFO16_01055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OFO16_01075	COG1482	cell wall glycoprotein biosynthetic process
OFO16_01090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OFO16_01110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OFO16_01120	COG0149	triose-phosphate isomerase activity
OFO16_01135	COG3152	Membrane
OFO16_01150	COG1494	fructose-1,6-bisphosphatase
OFO16_01160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OFO16_01165	COG1575	Belongs to the MenA family. Type 1 subfamily
OFO16_01170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OFO16_01185	COG1609	Transcriptional regulator
OFO16_01190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OFO16_01195	COG0254	rRNA binding
OFO16_01205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OFO16_01210	COG0088	Forms part of the polypeptide exit tunnel
OFO16_01220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OFO16_01225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OFO16_01230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OFO16_01235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OFO16_01245	COG0255	Belongs to the universal ribosomal protein uL29 family
OFO16_01250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OFO16_01260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OFO16_01265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OFO16_01280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OFO16_01295	COG1841	ribosomal large subunit assembly
OFO16_01300	COG0200	Binds to the 23S rRNA
OFO16_01305	COG0201	protein transport
OFO16_01310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OFO16_01315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OFO16_01320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OFO16_01330	COG0202	RNA polymerase activity
OFO16_01335	COG0203	ribosomal protein L17
OFO16_01345	COG0545	Peptidyl-prolyl cis-trans isomerase
OFO16_01355	COG2153	protein acetylation
OFO16_01360	COG0513	Belongs to the DEAD box helicase family
OFO16_01370	COG0737	Belongs to the 5'-nucleotidase family
OFO16_01375	COG1648	precorrin-2 dehydrogenase activity
OFO16_01375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OFO16_01380	COG0175	sulfate reduction
OFO16_01385	COG2895	sulfate adenylyltransferase (ATP) activity
OFO16_01390	COG0471	metal ion transport
OFO16_01390	COG3273	potassium ion transport
OFO16_01395	COG0529	Catalyzes the synthesis of activated sulfate
OFO16_01415	COG1136	(ABC) transporter
OFO16_01430	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
OFO16_01440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_01450	COG2911	Protein conserved in bacteria
OFO16_01455	COG2105	PFAM AIG2 family protein
OFO16_01460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OFO16_01465	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OFO16_01470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OFO16_01475	COG0163	prenyltransferase activity
OFO16_01485	COG1178	ABC-type Fe3 transport system permease component
OFO16_01490	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
OFO16_01515	COG0039	L-malate dehydrogenase activity
OFO16_01525	COG3385	transposase activity
OFO16_01530	COG0142	geranyltranstransferase activity
OFO16_01535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OFO16_01545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OFO16_01550	COG2966	Psort location CytoplasmicMembrane, score
OFO16_01570	COG2967	ApaG domain
OFO16_01575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OFO16_01580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OFO16_01585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFO16_01590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OFO16_01595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OFO16_01605	COG0066	3-isopropylmalate dehydratase activity
OFO16_01615	COG0473	3-isopropylmalate dehydrogenase activity
OFO16_01620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OFO16_01630	COG0671	phosphoesterase, PA-phosphatase related
OFO16_01640	COG0583	DNA-binding transcription factor activity
OFO16_01645	COG1022	Amp-dependent synthetase and ligase
OFO16_01650	COG0028	Belongs to the TPP enzyme family
OFO16_01655	COG0440	acetolactate synthase activity
OFO16_01660	COG3385	transposase activity
OFO16_01665	COG0469	pyruvate kinase activity
OFO16_01670	COG1349	DNA-binding transcription factor activity
OFO16_01675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OFO16_01685	COG2213	PTS system mannitol-specific
OFO16_01685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_01690	COG0246	Mannitol dehydrogenase
OFO16_01695	COG3722	fumarate hydratase activity
OFO16_01755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_01785	COG3293	Transposase
OFO16_01795	COG2378	regulation of single-species biofilm formation
OFO16_01825	COG3550	peptidyl-serine autophosphorylation
OFO16_01840	COG3339	Conserved Protein
OFO16_01920	COG0358	DNA primase activity
OFO16_01925	COG1610	YqeY-like protein
OFO16_01930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OFO16_01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OFO16_01940	COG3293	Transposase
OFO16_01945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OFO16_01950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OFO16_01955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OFO16_01960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OFO16_01965	COG1968	undecaprenyl-diphosphatase activity
OFO16_01970	COG0617	tRNA 3'-terminal CCA addition
OFO16_01975	COG3267	Type II secretory pathway component ExeA
OFO16_01975	COG3409	Peptidoglycan-binding domain 1 protein
OFO16_01985	COG4991	sh3 domain protein
OFO16_01990	COG0306	phosphate transporter
OFO16_01995	COG1392	Phosphate transport regulator
OFO16_02000	COG3025	triphosphatase activity
OFO16_02015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OFO16_02025	COG1538	Outer membrane efflux protein
OFO16_02030	COG0494	nUDIX hydrolase
OFO16_02035	COG3151	Protein conserved in bacteria
OFO16_02045	COG3150	esterase
OFO16_02055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OFO16_02060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OFO16_02070	COG3105	Protein conserved in bacteria
OFO16_02075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OFO16_02080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OFO16_02085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OFO16_02090	COG0723	plastoquinol--plastocyanin reductase activity
OFO16_02095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OFO16_02100	COG2857	Cytochrome c1
OFO16_02105	COG0625	glutathione transferase activity
OFO16_02110	COG2969	positive regulation of protein catabolic process
OFO16_02115	COG2823	Periplasmic or secreted lipoprotein
OFO16_02120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OFO16_02135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OFO16_02145	COG0275	rRNA processing
OFO16_02150	COG3116	cell division
OFO16_02155	COG0768	penicillin binding
OFO16_02160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OFO16_02165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OFO16_02170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OFO16_02175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OFO16_02180	COG0772	Belongs to the SEDS family
OFO16_02185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OFO16_02190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OFO16_02195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OFO16_02200	COG0849	cell division
OFO16_02205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OFO16_02210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OFO16_02220	COG0653	protein targeting
OFO16_02225	COG0494	nUDIX hydrolase
OFO16_02235	COG0505	Belongs to the CarA family
OFO16_02240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OFO16_02245	COG0730	response to heat
OFO16_02250	COG0583	DNA-binding transcription factor activity
OFO16_02255	COG2860	membrane
OFO16_02260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OFO16_02270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OFO16_02280	COG0493	'glutamate synthase
OFO16_02285	COG0067	glutamate synthase
OFO16_02285	COG0070	glutamate synthase
OFO16_02285	COG0069	glutamate synthase activity
OFO16_02295	COG0067	glutamate synthase
OFO16_02295	COG0070	glutamate synthase
OFO16_02295	COG0069	glutamate synthase activity
OFO16_02300	COG1242	4 iron, 4 sulfur cluster binding
OFO16_02305	COG2198	Histidine kinase
OFO16_02305	COG5002	protein histidine kinase activity
OFO16_02305	COG0784	Response regulator, receiver
OFO16_02315	COG0745	RESPONSE REGULATOR receiver
OFO16_02325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OFO16_02340	COG0083	homoserine kinase activity
OFO16_02345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OFO16_02350	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
OFO16_02355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OFO16_02360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OFO16_02375	COG1115	amino acid carrier protein
OFO16_02380	COG3022	response to hydroperoxide
OFO16_02385	COG0513	Belongs to the DEAD box helicase family
OFO16_02390	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OFO16_02405	COG4974	Belongs to the 'phage' integrase family
OFO16_02410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_02415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OFO16_02425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OFO16_02430	COG3829	transcription factor binding
OFO16_02430	COG3290	protein histidine kinase activity
OFO16_02440	COG0667	Aldo Keto reductase
OFO16_02450	COG3066	DNA modification
OFO16_02465	COG0730	response to heat
OFO16_02470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OFO16_02475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OFO16_02485	COG1283	sodium-dependent phosphate transmembrane transporter activity
OFO16_02490	COG0583	DNA-binding transcription factor activity
OFO16_02495	COG0640	Transcriptional regulator
OFO16_02500	COG0268	Binds directly to 16S ribosomal RNA
OFO16_02505	COG0728	peptidoglycan biosynthetic process
OFO16_02510	COG0196	riboflavin kinase activity
OFO16_02515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OFO16_02520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OFO16_02525	COG1047	Peptidyl-prolyl cis-trans
OFO16_02530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OFO16_02535	COG3279	Response regulator of the LytR AlgR family
OFO16_02540	COG3275	phosphorelay sensor kinase activity
OFO16_02545	COG1966	Carbon starvation protein
OFO16_02565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OFO16_02570	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_02575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFO16_02580	COG0287	Prephenate dehydrogenase
OFO16_02580	COG1605	Chorismate mutase
OFO16_02585	COG0739	heme binding
OFO16_02590	COG0488	(ABC) transporter
OFO16_02600	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
OFO16_02605	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
OFO16_02610	COG0077	Prephenate dehydratase
OFO16_02610	COG1605	Chorismate mutase
OFO16_02615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OFO16_02620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OFO16_02625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_02630	COG0564	pseudouridine synthase activity
OFO16_02640	COG0542	response to heat
OFO16_02655	COG1116	anion transmembrane transporter activity
OFO16_02710	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
OFO16_02720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFO16_02725	COG0826	peptidase U32
OFO16_02730	COG2974	May be involved in recombination
OFO16_02735	COG0745	RESPONSE REGULATOR receiver
OFO16_02740	COG5002	protein histidine kinase activity
OFO16_02750	COG0248	Ppx GppA phosphatase
OFO16_02755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OFO16_02765	COG0581	inorganic phosphate transmembrane transporter activity
OFO16_02770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OFO16_02775	COG0704	Plays a role in the regulation of phosphate uptake
OFO16_02785	COG3142	Participates in the control of copper homeostasis
OFO16_02790	COG0450	alkyl hydroperoxide reductase
OFO16_02795	COG0583	DNA-binding transcription factor activity
OFO16_02800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OFO16_02810	COG0517	IMP dehydrogenase activity
OFO16_02820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OFO16_02825	COG0343	queuine tRNA-ribosyltransferase activity
OFO16_02830	COG1862	Preprotein translocase
OFO16_02835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_02840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_02845	COG0483	inositol monophosphate 1-phosphatase activity
OFO16_02850	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
OFO16_02860	COG1104	cysteine desulfurase activity
OFO16_02865	COG0822	iron-sulfur transferase activity
OFO16_02870	COG0316	Belongs to the HesB IscA family
OFO16_02880	COG0443	Heat shock 70 kDa protein
OFO16_02885	COG0633	Ferredoxin
OFO16_02890	COG2975	iron-sulfur cluster assembly
OFO16_02895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OFO16_02900	COG0105	UTP biosynthetic process
OFO16_02915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OFO16_02920	COG0124	histidyl-tRNA synthetase
OFO16_02925	COG2976	Protein conserved in bacteria
OFO16_02930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_02935	COG1160	GTP binding
OFO16_02940	COG3293	Transposase
OFO16_02960	COG0516	GMP reductase activity
OFO16_02960	COG0517	IMP dehydrogenase activity
OFO16_02965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OFO16_02965	COG0519	Catalyzes the synthesis of GMP from XMP
OFO16_02970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OFO16_02975	COG0235	Class ii aldolase
OFO16_02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OFO16_02990	COG0235	Class ii aldolase
OFO16_02995	COG1620	l-lactate permease
OFO16_03000	COG1620	l-lactate permease
OFO16_03020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_03025	COG2169	Transcriptional regulator
OFO16_03025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OFO16_03035	COG3093	addiction module antidote protein HigA
OFO16_03045	COG1757	Na H antiporter
OFO16_03050	COG1584	GPR1 FUN34 yaaH family protein
OFO16_03065	COG1473	amidohydrolase
OFO16_03075	COG1115	amino acid carrier protein
OFO16_03080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_03090	COG2873	o-acetylhomoserine
OFO16_03095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_03115	COG3153	acetyltransferase
OFO16_03115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OFO16_03120	COG0583	DNA-binding transcription factor activity
OFO16_03125	COG0235	Class ii aldolase
OFO16_03130	COG4806	L-rhamnose isomerase
OFO16_03135	COG1070	Carbohydrate kinase
OFO16_03140	COG3254	rhamnose metabolic process
OFO16_03225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OFO16_03230	COG2867	negative regulation of translational initiation
OFO16_03235	COG2914	Belongs to the UPF0125 (RnfH) family
OFO16_03240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFO16_03245	COG0497	DNA recombination
OFO16_03250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OFO16_03255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OFO16_03260	COG1301	dicarboxylic acid transport
OFO16_03270	COG0484	heat shock protein binding
OFO16_03300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OFO16_03315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OFO16_03320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OFO16_03320	COG0047	phosphoribosylformylglycinamidine synthase activity
OFO16_03350	COG3385	transposase activity
OFO16_03355	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFO16_03360	COG2252	PERMEase
OFO16_03365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
OFO16_03370	COG1073	alpha beta
OFO16_03380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OFO16_03385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OFO16_03390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OFO16_03395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OFO16_03395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OFO16_03410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OFO16_03420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OFO16_03425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OFO16_03430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OFO16_03435	COG0142	geranyltranstransferase activity
OFO16_03445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OFO16_03450	COG2885	chlorophyll binding
OFO16_03455	COG0301	tRNA thio-modification
OFO16_03455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFO16_03460	COG0583	DNA-binding transcription factor activity
OFO16_03470	COG2363	Small membrane protein
OFO16_03475	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
OFO16_03480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFO16_03485	COG1611	Belongs to the LOG family
OFO16_03510	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
OFO16_03515	COG1464	Belongs to the NlpA lipoprotein family
OFO16_03520	COG2011	ABC-type metal ion transport system permease component
OFO16_03525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OFO16_03530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OFO16_03540	COG1263	PTS System
OFO16_03540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_03545	COG0366	Alpha amylase catalytic
OFO16_03555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFO16_03560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OFO16_03575	COG1686	Belongs to the peptidase S11 family
OFO16_03580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OFO16_03585	COG0772	Belongs to the SEDS family
OFO16_03590	COG0768	penicillin binding
OFO16_03600	COG0799	negative regulation of ribosome biogenesis
OFO16_03605	COG1466	dna polymerase III delta subunit
OFO16_03610	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
OFO16_03615	COG0495	leucyl-tRNA aminoacylation
OFO16_03620	COG2888	peptidyl-tyrosine sulfation
OFO16_03625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
OFO16_03630	COG4535	Mg2 and Co2 transporter CorC
OFO16_03640	COG1702	phosphate starvation-inducible protein PhoH
OFO16_03645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OFO16_03650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_03760	COG0012	GTP binding
OFO16_03770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OFO16_03775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OFO16_03780	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OFO16_03785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OFO16_03795	COG2890	protein-(glutamine-N5) methyltransferase activity
OFO16_03800	COG3094	Invasion gene expression up-regulator, SirB
OFO16_03805	COG2912	Transglutaminase-like superfamily
OFO16_03810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OFO16_03815	COG0737	Belongs to the 5'-nucleotidase family
OFO16_03820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OFO16_03825	COG3385	transposase activity
OFO16_03830	COG1187	pseudouridine synthase activity
OFO16_03835	COG2840	Smr protein MutS2
OFO16_03865	COG2217	Heavy metal translocating P-type atpase
OFO16_03865	COG2608	mercury ion transmembrane transporter activity
OFO16_03920	COG0835	chemotaxis
OFO16_03920	COG0784	Response regulator, receiver
OFO16_03925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OFO16_03930	COG1815	bacterial-type flagellum-dependent cell motility
OFO16_03945	COG1749	Flagellar hook protein flgE
OFO16_03950	COG4787	bacterial-type flagellum-dependent cell motility
OFO16_03960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
OFO16_03965	COG1706	bacterial-type flagellum-dependent cell motility
OFO16_03970	COG1705	Flagellar rod assembly protein muramidase FlgJ
OFO16_03970	COG3951	Flagellar rod assembly protein muramidase FlgJ
OFO16_03980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_03990	COG2190	(PTS) system
OFO16_03995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OFO16_04000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_04005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OFO16_04010	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
OFO16_04015	COG3115	cell septum assembly
OFO16_04020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OFO16_04050	COG0330	HflC and HflK could
OFO16_04055	COG3118	belongs to the thioredoxin family
OFO16_04060	COG0300	oxidoreductase activity
OFO16_04065	COG1090	epimerase
OFO16_04095	COG0622	Phosphoesterase
OFO16_04115	COG3710	Transcriptional regulator
OFO16_04120	COG0326	Molecular chaperone. Has ATPase activity
OFO16_04130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OFO16_04140	COG3104	oligopeptide transport
OFO16_04150	COG0367	asparagine synthase
OFO16_04155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OFO16_04155	COG4651	solute:proton antiporter activity
OFO16_04160	COG1846	Transcriptional regulator
OFO16_04160	COG1940	carbohydrate kinase activity
OFO16_04165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OFO16_04170	COG1263	PTS System
OFO16_04170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_04170	COG2190	(PTS) system
OFO16_04175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OFO16_04180	COG0735	belongs to the Fur family
OFO16_04190	COG0716	FMN binding
OFO16_04200	COG0596	Alpha beta hydrolase
OFO16_04205	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
OFO16_04210	COG0033	Phosphoglucomutase
OFO16_04220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OFO16_04235	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OFO16_04240	COG1053	succinate dehydrogenase
OFO16_04250	COG0567	Dehydrogenase, E1 component
OFO16_04255	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFO16_04260	COG0045	succinate-CoA ligase (ADP-forming) activity
OFO16_04270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OFO16_04275	COG1121	(ABC) transporter
OFO16_04280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
OFO16_04285	COG4977	sequence-specific DNA binding
OFO16_04290	COG1918	ferrous iron import across plasma membrane
OFO16_04310	COG0018	arginyl-trna synthetase
OFO16_04315	COG3102	Protein conserved in bacteria
OFO16_04330	COG3385	transposase activity
OFO16_04335	COG0788	formyltetrahydrofolate deformylase activity
OFO16_04340	COG1199	ATP-dependent helicase activity
OFO16_04345	COG1214	PFAM Peptidase M22, glycoprotease
OFO16_04360	COG2267	carboxylic ester hydrolase activity
OFO16_04365	COG0318	PFAM AMP-dependent synthetase and ligase
OFO16_04370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
OFO16_04375	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
OFO16_04380	COG2894	cell division
OFO16_04390	COG3100	YcgL domain-containing protein
OFO16_04395	COG2951	lytic endotransglycosylase activity
OFO16_04400	COG0583	DNA-binding transcription factor activity
OFO16_04405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFO16_04410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OFO16_04425	COG0583	DNA-binding transcription factor activity
OFO16_04430	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OFO16_04435	COG1301	dicarboxylic acid transport
OFO16_04440	COG2855	membrane
OFO16_04460	COG0402	S-adenosylhomocysteine deaminase activity
OFO16_04545	COG0732	type I restriction modification DNA specificity domain
OFO16_04615	COG1396	sequence-specific DNA binding
OFO16_04620	COG3550	peptidyl-serine autophosphorylation
OFO16_04630	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_04640	COG1169	isochorismate synthase
OFO16_04645	COG1021	2,3-dihydroxybenzoate-AMP ligase
OFO16_04650	COG1535	isochorismatase
OFO16_04650	COG3433	isochorismatase activity
OFO16_04655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OFO16_04655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OFO16_04670	COG4771	TonB-dependent receptor
OFO16_04675	COG1253	flavin adenine dinucleotide binding
OFO16_04680	COG0513	Belongs to the DEAD box helicase family
OFO16_04685	COG0569	domain protein
OFO16_04690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFO16_04695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OFO16_04715	COG1175	transmembrane transport
OFO16_04725	COG3842	ATPase activity
OFO16_04730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_04735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFO16_04740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFO16_04760	COG3293	Transposase
OFO16_04775	COG0544	peptidyl-prolyl cis-trans isomerase activity
OFO16_04785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OFO16_04790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OFO16_04795	COG0776	regulation of translation
OFO16_04800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFO16_04805	COG1555	photosystem II stabilization
OFO16_04820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
OFO16_04825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OFO16_04830	COG0436	Aminotransferase
OFO16_04835	COG1169	isochorismate synthase
OFO16_04840	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OFO16_04845	COG0596	Alpha beta hydrolase
OFO16_04850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OFO16_04870	COG2855	membrane
OFO16_04875	COG0477	Major facilitator Superfamily
OFO16_04915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_04920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_04935	COG1522	sequence-specific DNA binding
OFO16_04940	COG1946	Acyl-CoA thioesterase
OFO16_04945	COG3126	Type III secretion system lipoprotein chaperone (YscW)
OFO16_04965	COG0583	DNA-binding transcription factor activity
OFO16_04980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OFO16_04985	COG3842	ATPase activity
OFO16_05000	COG0439	Biotin carboxylase
OFO16_05010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_05015	COG0174	glutamine synthetase
OFO16_05020	COG0174	glutamine synthetase
OFO16_05030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFO16_05035	COG3842	ATPase activity
OFO16_05040	COG1176	ABC-type spermidine putrescine transport system, permease component I
OFO16_05045	COG1177	transmembrane transport
OFO16_05055	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_05060	COG0519	Catalyzes the synthesis of GMP from XMP
OFO16_05065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFO16_05070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OFO16_05075	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
OFO16_05080	COG0516	GMP reductase activity
OFO16_05080	COG0517	IMP dehydrogenase activity
OFO16_05085	COG2217	Heavy metal translocating P-type atpase
OFO16_05105	COG0537	adenosine 5'-monophosphoramidase activity
OFO16_05130	COG3150	esterase
OFO16_05135	COG1252	NADH dehydrogenase
OFO16_05150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OFO16_05160	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFO16_05165	COG1136	(ABC) transporter
OFO16_05170	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFO16_05180	COG2333	competence protein COMEC
OFO16_05180	COG0658	competence protein
OFO16_05185	COG1132	(ABC) transporter
OFO16_05200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OFO16_05205	COG2719	SpoVR family
OFO16_05210	COG2718	Belongs to the UPF0229 family
OFO16_05215	COG2766	serine protein kinase
OFO16_05220	COG3013	Belongs to the UPF0304 family
OFO16_05230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OFO16_05240	COG1882	Formate acetyltransferase
OFO16_05275	COG0708	Exodeoxyribonuclease III
OFO16_05285	COG3923	Primosomal replication protein n
OFO16_05290	COG0730	response to heat
OFO16_05295	COG1199	ATP-dependent helicase activity
OFO16_05305	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OFO16_05310	COG1187	pseudouridine synthase activity
OFO16_05320	COG1278	Cold shock
OFO16_05325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OFO16_05330	COG0542	response to heat
OFO16_05335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OFO16_05340	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OFO16_05345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OFO16_05355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OFO16_05365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OFO16_05370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OFO16_05375	COG0297	glycogen (starch) synthase activity
OFO16_05395	COG3070	regulator of competence-specific genes
OFO16_05400	COG1609	Transcriptional regulator
OFO16_05405	COG3381	protein complex oligomerization
OFO16_05410	COG0745	RESPONSE REGULATOR receiver
OFO16_05415	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OFO16_05420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFO16_05425	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
OFO16_05430	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
OFO16_05435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
OFO16_05470	COG4067	protein conserved in archaea
OFO16_05470	COG0189	ligase activity
OFO16_05475	COG0500	methyltransferase
OFO16_05480	COG4106	trans-aconitate 2-methyltransferase activity
OFO16_05485	COG1801	Protein of unknown function DUF72
OFO16_05495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OFO16_05500	COG0632	four-way junction helicase activity
OFO16_05505	COG2255	four-way junction helicase activity
OFO16_05510	COG1271	oxidase subunit
OFO16_05515	COG1294	oxidase, subunit
OFO16_05520	COG4890	Cyd operon protein YbgT
OFO16_05530	COG0824	Thioesterase
OFO16_05535	COG0811	peptide transport
OFO16_05550	COG0823	Involved in the tonB-independent uptake of proteins
OFO16_05555	COG2885	chlorophyll binding
OFO16_05560	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
OFO16_05575	COG3766	membrane
OFO16_05585	COG0754	glutathionylspermidine amidase activity
OFO16_05600	COG1858	cytochrome C peroxidase
OFO16_05620	COG2205	protein histidine kinase activity
OFO16_05620	COG0784	Response regulator, receiver
OFO16_05645	COG2194	sulfuric ester hydrolase activity
OFO16_05675	COG1215	transferase activity, transferring glycosyl groups
OFO16_05680	COG1215	transferase activity, transferring glycosyl groups
OFO16_05685	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
OFO16_05765	COG3052	prosthetic group binding
OFO16_05780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OFO16_05785	COG1396	sequence-specific DNA binding
OFO16_05790	COG3135	benzoate transporter
OFO16_05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_05800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_05835	COG0686	Belongs to the AlaDH PNT family
OFO16_05845	COG1674	ftsk spoiiie
OFO16_05850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OFO16_05855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OFO16_05865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_05875	COG0156	8-amino-7-oxononanoate synthase activity
OFO16_05885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OFO16_05895	COG0501	Belongs to the peptidase M48B family
OFO16_05905	COG4221	oxidoreductase activity
OFO16_05920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OFO16_05940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OFO16_05950	COG0482	sulfurtransferase activity
OFO16_05960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_05970	COG1757	Na H antiporter
OFO16_05985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OFO16_05990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OFO16_05995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OFO16_06000	COG0131	Imidazoleglycerol-phosphate dehydratase
OFO16_06000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OFO16_06005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OFO16_06010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OFO16_06020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OFO16_06020	COG0140	phosphoribosyl-ATP diphosphatase activity
OFO16_06025	COG3012	SEC-C Motif Domain Protein
OFO16_06030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
OFO16_06035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_06040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OFO16_06045	COG0215	cysteine-tRNA ligase activity
OFO16_06050	COG1435	thymidine kinase activity
OFO16_06055	COG3385	transposase activity
OFO16_06060	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OFO16_06075	COG2116	formate transmembrane transporter activity
OFO16_06085	COG0390	transport system, permease component
OFO16_06090	COG4459	periplasmic nitrate reductase
OFO16_06095	COG3005	denitrification pathway
OFO16_06100	COG0243	molybdopterin cofactor binding
OFO16_06115	COG1227	inorganic diphosphatase activity
OFO16_06125	COG4172	Belongs to the ABC transporter superfamily
OFO16_06150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OFO16_06155	COG1842	Phage shock protein A
OFO16_06165	COG1983	PspC domain protein
OFO16_06185	COG2818	Glycosylase
OFO16_06190	COG0626	cystathionine gamma-synthase activity
OFO16_06200	COG0733	neurotransmitter:sodium symporter activity
OFO16_06205	COG0564	pseudouridine synthase activity
OFO16_06210	COG0116	Belongs to the methyltransferase superfamily
OFO16_06210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFO16_06215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_06220	COG1151	hydroxylamine reductase activity
OFO16_06225	COG3604	Transcriptional regulator
OFO16_06235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OFO16_06240	COG4136	ATPase activity
OFO16_06245	COG4135	transport system, permease component
OFO16_06250	COG4134	Bacterial extracellular solute-binding protein
OFO16_06260	COG3313	Fe-S protein
OFO16_06275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OFO16_06280	COG0642	Histidine kinase
OFO16_06295	COG1061	Type III restriction enzyme res subunit
OFO16_06300	COG1187	pseudouridine synthase activity
OFO16_06305	COG2814	Major facilitator Superfamily
OFO16_06335	COG3005	denitrification pathway
OFO16_06340	COG0702	epimerase
OFO16_06345	COG0534	Mate efflux family protein
OFO16_06350	COG1136	(ABC) transporter
OFO16_06365	COG3385	transposase activity
OFO16_06370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFO16_06380	COG1960	acyl-CoA dehydrogenase activity
OFO16_06385	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OFO16_06390	COG2985	domain, Protein
OFO16_06390	COG3273	potassium ion transport
OFO16_06395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OFO16_06400	COG1454	alcohol dehydrogenase
OFO16_06400	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_06405	COG3385	transposase activity
OFO16_06410	COG1737	Transcriptional regulator
OFO16_06415	COG0076	glutamate decarboxylase activity
OFO16_06425	COG2431	L-lysine efflux transmembrane transporter activity
OFO16_06435	COG3070	regulator of competence-specific genes
OFO16_06450	COG4191	Histidine kinase
OFO16_06450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_06460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
OFO16_06470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OFO16_06475	COG4988	ABC transporter
OFO16_06480	COG0492	ferredoxin-NADP+ reductase activity
OFO16_06500	COG0471	metal ion transport
OFO16_06505	COG2949	membrane
OFO16_06510	COG0281	malic enzyme
OFO16_06515	COG1643	Atp-dependent helicase
OFO16_06530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OFO16_06565	COG0247	lactate metabolic process
OFO16_06565	COG0277	FAD linked oxidase domain protein
OFO16_06570	COG2020	methyltransferase activity
OFO16_06575	COG0583	DNA-binding transcription factor activity
OFO16_06580	COG3384	dioxygenase
OFO16_06585	COG0435	Glutathione S-transferase
OFO16_06595	COG0010	Belongs to the arginase family
OFO16_06600	COG1228	amidohydrolase
OFO16_06620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OFO16_06630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OFO16_06645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OFO16_06650	COG0072	phenylalanine-tRNA ligase activity
OFO16_06650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_06655	COG1621	beta-fructofuranosidase activity
OFO16_06660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_06675	COG0776	regulation of translation
OFO16_06685	COG0500	methyltransferase
OFO16_06690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
OFO16_06695	COG0295	cytidine deaminase activity
OFO16_06700	COG1346	cytolysis
OFO16_06705	COG1380	Effector of murein hydrolase LrgA
OFO16_06710	COG2925	Exonuclease
OFO16_06735	COG1823	symporter activity
OFO16_06740	COG0702	epimerase
OFO16_06745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OFO16_06755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
OFO16_06775	COG2988	succinylglutamate desuccinylase activity
OFO16_06780	COG4139	cobalamin transport
OFO16_06805	COG0583	DNA-binding transcription factor activity
OFO16_06815	COG1451	nucleotide metabolic process
OFO16_06820	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
OFO16_06850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OFO16_06855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_06870	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFO16_06880	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
OFO16_06890	COG0625	glutathione transferase activity
OFO16_06915	COG4145	pantothenate transmembrane transporter activity
OFO16_06930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OFO16_06950	COG0579	oxidoreductase
OFO16_07080	COG1953	Uracil, thiamine, allantoin
OFO16_07095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OFO16_07110	COG2059	Chromate
OFO16_07115	COG2059	Chromate
OFO16_07145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OFO16_07155	COG1414	Transcriptional regulator
OFO16_07160	COG0400	carboxylic ester hydrolase activity
OFO16_07170	COG5002	protein histidine kinase activity
OFO16_07170	COG0784	Response regulator, receiver
OFO16_07170	COG2198	Histidine kinase
OFO16_07180	COG0559	Belongs to the binding-protein-dependent transport system permease family
OFO16_07200	COG0829	nickel cation binding
OFO16_07205	COG0831	urea catabolic process
OFO16_07210	COG0832	Belongs to the urease beta subunit family
OFO16_07215	COG0804	urea catabolic process
OFO16_07225	COG0830	nickel cation binding
OFO16_07230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OFO16_07240	COG0471	metal ion transport
OFO16_07245	COG4191	Histidine kinase
OFO16_07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_07265	COG0814	amino acid
OFO16_07285	COG1132	(ABC) transporter
OFO16_07290	COG1132	(ABC) transporter
OFO16_07310	COG0443	Heat shock 70 kDa protein
OFO16_07360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OFO16_07365	COG1643	Atp-dependent helicase
OFO16_07380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_07390	COG1793	dna ligase
OFO16_07400	COG0534	Mate efflux family protein
OFO16_07405	COG0307	riboflavin synthase, alpha
OFO16_07415	COG3001	Fructosamine kinase
OFO16_07420	COG2201	protein-glutamate methylesterase activity
OFO16_07425	COG3706	GGDEF domain
OFO16_07435	COG0791	NLP P60 protein
OFO16_07440	COG0840	transmembrane signaling receptor activity
OFO16_07455	COG3148	PFAM DTW domain containing protein
OFO16_07465	COG3293	Transposase
OFO16_07485	COG0303	'Molybdopterin
OFO16_07495	COG3842	ATPase activity
OFO16_07510	COG2204	response regulator
OFO16_07515	COG4191	Histidine kinase
OFO16_07520	COG0488	(ABC) transporter
OFO16_07525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OFO16_07555	COG0243	molybdopterin cofactor binding
OFO16_07555	COG3383	formate dehydrogenase (NAD+) activity
OFO16_07560	COG0437	4 iron, 4 sulfur cluster binding
OFO16_07575	COG0004	ammonium transporteR
OFO16_07585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OFO16_07590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFO16_07600	COG1177	transmembrane transport
OFO16_07610	COG3842	ATPase activity
OFO16_07625	COG0037	tRNA processing
OFO16_07630	COG0589	response to stress
OFO16_07635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_07650	COG2217	Heavy metal translocating P-type atpase
OFO16_07660	COG2010	Cytochrome c
OFO16_07675	COG3278	Belongs to the heme-copper respiratory oxidase family
OFO16_07690	COG2205	protein histidine kinase activity
OFO16_07690	COG0784	Response regulator, receiver
OFO16_07775	COG3120	sequence-specific DNA binding
OFO16_07780	COG1067	ATP-dependent peptidase activity
OFO16_07785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OFO16_07800	COG0488	(ABC) transporter
OFO16_07810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFO16_07810	COG0116	Belongs to the methyltransferase superfamily
OFO16_07820	COG0167	dihydroorotate dehydrogenase activity
OFO16_07830	COG2902	Dehydrogenase
OFO16_07840	COG0308	aminopeptidase N
OFO16_07855	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
OFO16_07860	COG1956	GAF domain-containing protein
OFO16_07865	COG1132	(ABC) transporter
OFO16_07870	COG2995	paraquat-inducible protein a
OFO16_07875	COG3008	intermembrane lipid transfer
OFO16_07880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OFO16_07880	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
OFO16_07900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFO16_07905	COG1666	GTP binding
OFO16_07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_07925	COG4597	amino acid ABC transporter
OFO16_07930	COG0765	amino acid transport
OFO16_07935	COG1126	abc transporter atp-binding protein
OFO16_07940	COG0670	Belongs to the BI1 family
OFO16_07950	COG2920	part of a sulfur-relay system
OFO16_07955	COG1254	Belongs to the acylphosphatase family
OFO16_07960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFO16_07980	COG2885	chlorophyll binding
OFO16_07990	COG3706	GGDEF domain
OFO16_08000	COG0602	queuosine metabolic process
OFO16_08005	COG0561	phosphatase activity
OFO16_08010	COG0110	maltose O-acetyltransferase activity
OFO16_08030	COG3300	MHYT domain
OFO16_08030	COG5001	Diguanylate cyclase
OFO16_08070	COG2828	Protein conserved in bacteria
OFO16_08080	COG0372	Belongs to the citrate synthase family
OFO16_08085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OFO16_08115	COG0730	response to heat
OFO16_08120	COG2358	TRAP transporter, solute receptor (TAXI family
OFO16_08125	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_08130	COG3284	Transcriptional regulator
OFO16_08145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OFO16_08150	COG0363	glucosamine-6-phosphate deaminase activity
OFO16_08155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OFO16_08160	COG2207	Transcriptional regulator
OFO16_08165	COG4774	siderophore transport
OFO16_08170	COG4565	transcriptional regulatory protein
OFO16_08175	COG3290	protein histidine kinase activity
OFO16_08190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_08205	COG0527	aspartate kinase activity
OFO16_08215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_08220	COG0456	acetyltransferase
OFO16_08230	COG4176	ABC-type proline glycine betaine transport system permease component
OFO16_08235	COG2113	Glycine betaine
OFO16_08255	COG4221	oxidoreductase activity
OFO16_08265	COG0745	RESPONSE REGULATOR receiver
OFO16_08270	COG0642	Histidine kinase
OFO16_08275	COG1368	sulfuric ester hydrolase activity
OFO16_08310	COG1115	amino acid carrier protein
OFO16_08325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OFO16_08330	COG1280	lysine exporter protein (LysE YggA)
OFO16_08335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OFO16_08355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OFO16_08360	COG1289	transmembrane transporter activity
OFO16_08365	COG1566	PFAM secretion protein HlyD family protein
OFO16_08390	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_08395	COG1560	Kdo2-lipid A biosynthetic process
OFO16_08405	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OFO16_08410	COG3063	Type IV pilus biogenesis stability protein PilW
OFO16_08440	COG2315	Protein conserved in bacteria
OFO16_08445	COG1846	Transcriptional regulator
OFO16_08450	COG0697	spore germination
OFO16_08455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_08460	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_08465	COG2957	Belongs to the agmatine deiminase family
OFO16_08475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_08480	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_08485	COG1396	sequence-specific DNA binding
OFO16_08485	COG1917	Cupin 2, conserved barrel domain protein
OFO16_08495	COG0174	glutamine synthetase
OFO16_08500	COG1757	Na H antiporter
OFO16_08525	COG3121	Chaperone
OFO16_08550	COG2824	Alkylphosphonate utilization operon protein PhnA
OFO16_08585	COG0346	lactoylglutathione lyase activity
OFO16_08615	COG1794	racemase activity, acting on amino acids and derivatives
OFO16_08620	COG4977	sequence-specific DNA binding
OFO16_08640	COG0724	RNA recognition motif
OFO16_08650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OFO16_08655	COG1882	Formate acetyltransferase
OFO16_08680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
OFO16_08685	COG4656	Part of a membrane complex involved in electron transport
OFO16_08690	COG3550	peptidyl-serine autophosphorylation
OFO16_08770	COG3706	GGDEF domain
OFO16_08795	COG2188	Transcriptional regulator
OFO16_08800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_08800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_08800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_08805	COG0383	alpha-mannosidase activity
OFO16_08810	COG1929	Belongs to the glycerate kinase type-1 family
OFO16_08820	COG3293	Transposase
OFO16_08825	COG1609	Transcriptional regulator
OFO16_08835	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_08845	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_08850	COG0583	DNA-binding transcription factor activity
OFO16_08855	COG0604	alcohol dehydrogenase
OFO16_08860	COG0583	DNA-binding transcription factor activity
OFO16_08880	COG0583	DNA-binding transcription factor activity
OFO16_08930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFO16_08940	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
OFO16_08950	COG4820	ethanolamine utilization protein (EutJ)
OFO16_08955	COG4869	propanediol catabolic process
OFO16_09000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFO16_09010	COG3768	UPF0283 membrane protein
OFO16_09015	COG3106	COG3106 Predicted ATPase
OFO16_09030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OFO16_09040	COG0814	amino acid
OFO16_09045	COG1760	l-serine dehydratase
OFO16_09055	COG0720	synthase
OFO16_09060	COG0017	Asparaginyl-tRNA synthetase
OFO16_09070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OFO16_09080	COG1448	Aminotransferase
OFO16_09095	COG2176	DNA-directed DNA polymerase activity
OFO16_09105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_09115	COG1846	Transcriptional regulator
OFO16_09140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFO16_09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OFO16_09160	COG3108	Peptidase M15
OFO16_09165	COG2989	Protein conserved in bacteria
OFO16_09190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OFO16_09205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFO16_09210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OFO16_09240	COG0019	diaminopimelate decarboxylase activity
OFO16_09280	COG0322	excinuclease ABC activity
OFO16_09285	COG2197	response regulator
OFO16_09290	COG0417	DNA replication proofreading
OFO16_09300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OFO16_09305	COG3099	Belongs to the UPF0263 family
OFO16_09310	COG1187	pseudouridine synthase activity
OFO16_09320	COG0009	L-threonylcarbamoyladenylate synthase
OFO16_09325	COG0613	PHP domain protein
OFO16_09335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OFO16_09340	COG0512	Glutamine amidotransferase of anthranilate synthase
OFO16_09345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OFO16_09350	COG0134	indole-3-glycerol-phosphate synthase activity
OFO16_09350	COG0135	phosphoribosylanthranilate isomerase activity
OFO16_09355	COG0133	tryptophan synthase activity
OFO16_09360	COG0159	tryptophan synthase activity
OFO16_09365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_09370	COG0318	PFAM AMP-dependent synthetase and ligase
OFO16_09375	COG1301	dicarboxylic acid transport
OFO16_09400	COG2350	Protein conserved in bacteria
OFO16_09410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OFO16_09415	COG0583	DNA-binding transcription factor activity
OFO16_09430	COG5001	Diguanylate cyclase
OFO16_09435	COG1032	radical SAM domain protein
OFO16_09440	COG0745	RESPONSE REGULATOR receiver
OFO16_09445	COG3850	Histidine kinase
OFO16_09445	COG5002	protein histidine kinase activity
OFO16_09480	COG3118	belongs to the thioredoxin family
OFO16_09485	COG4232	protein-disulfide reductase activity
OFO16_09495	COG1902	pentaerythritol trinitrate reductase activity
OFO16_09500	COG3302	dmso reductase anchor subunit
OFO16_09505	COG0437	4 iron, 4 sulfur cluster binding
OFO16_09510	COG0243	molybdopterin cofactor binding
OFO16_09525	COG0189	ligase activity
OFO16_09530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OFO16_09540	COG2308	Evidence 4 Homologs of previously reported genes of
OFO16_09555	COG2308	Evidence 4 Homologs of previously reported genes of
OFO16_09555	COG2307	Protein conserved in bacteria
OFO16_09605	COG3258	Cytochrome c
OFO16_09610	COG2995	paraquat-inducible protein a
OFO16_09615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OFO16_09615	COG3008	intermembrane lipid transfer
OFO16_09620	COG3009	Protein conserved in bacteria
OFO16_09625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OFO16_09635	COG0463	Glycosyl transferase, family 2
OFO16_09660	COG4166	transmembrane transport
OFO16_09670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OFO16_09675	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
OFO16_09685	COG0539	negative regulation of cytoplasmic translation
OFO16_09690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OFO16_09695	COG0616	signal peptide processing
OFO16_09700	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_09715	COG0587	DNA-directed DNA polymerase activity
OFO16_09720	COG1940	carbohydrate kinase activity
OFO16_09725	COG0469	pyruvate kinase activity
OFO16_09730	COG4667	esterase of the alpha-beta hydrolase superfamily
OFO16_09745	COG0733	neurotransmitter:sodium symporter activity
OFO16_09760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_09760	COG1263	PTS System
OFO16_09770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_09770	COG1263	PTS System
OFO16_09770	COG2190	(PTS) system
OFO16_09775	COG0084	hydrolase, TatD family'
OFO16_09780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OFO16_09785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OFO16_09790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OFO16_09820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OFO16_09825	COG0416	fatty acid biosynthetic process
OFO16_09835	COG1399	metal-binding, possibly nucleic acid-binding protein
OFO16_09840	COG0424	maF-like protein
OFO16_09845	COG0564	pseudouridine synthase activity
OFO16_09850	COG1530	ribonuclease E activity
OFO16_09855	COG0659	secondary active sulfate transmembrane transporter activity
OFO16_09860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OFO16_09865	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
OFO16_09875	COG0572	uridine kinase
OFO16_09880	COG0489	protein tyrosine kinase activity
OFO16_09885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_09885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_09895	COG2186	Transcriptional regulator
OFO16_09900	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFO16_09905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OFO16_09910	COG0653	protein targeting
OFO16_09915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFO16_09920	COG2199	diguanylate cyclase activity
OFO16_09925	COG0366	Alpha amylase catalytic
OFO16_09930	COG1122	ATPase activity
OFO16_09935	COG4120	Belongs to the binding-protein-dependent transport system permease family
OFO16_09945	COG3092	negative regulation of chromosome organization
OFO16_09950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFO16_09955	COG0857	belongs to the CobB CobQ family
OFO16_09955	COG0280	phosphate acetyltransferase
OFO16_09965	COG3174	membrane
OFO16_09970	COG0435	Glutathione S-transferase
OFO16_09980	COG0444	Belongs to the ABC transporter superfamily
OFO16_09985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_09990	COG0601	transmembrane transport
OFO16_10000	COG3293	Transposase
OFO16_10005	COG0314	molybdopterin synthase activity
OFO16_10010	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OFO16_10015	COG0315	cyclic pyranopterin monophosphate synthase activity
OFO16_10020	COG0521	Mo-molybdopterin cofactor biosynthetic process
OFO16_10025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OFO16_10030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OFO16_10035	COG2198	Histidine kinase
OFO16_10040	COG2204	response regulator
OFO16_10045	COG0556	nucleotide-excision repair
OFO16_10055	COG4657	Part of a membrane complex involved in electron transport
OFO16_10060	COG2878	Part of a membrane complex involved in electron transport
OFO16_10065	COG4656	Part of a membrane complex involved in electron transport
OFO16_10070	COG4658	electron transport chain
OFO16_10075	COG4659	FMN binding
OFO16_10080	COG4660	Part of a membrane complex involved in electron transport
OFO16_10085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OFO16_10095	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OFO16_10110	COG0346	lactoylglutathione lyase activity
OFO16_10120	COG2885	chlorophyll binding
OFO16_10125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OFO16_10130	COG2056	Na+-H+ antiporter family
OFO16_10135	COG3385	transposase activity
OFO16_10145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OFO16_10160	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_10165	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_10165	COG1454	alcohol dehydrogenase
OFO16_10170	COG2095	MarC family integral membrane protein
OFO16_10175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_10180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OFO16_10185	COG1757	Na H antiporter
OFO16_10205	COG3081	Nucleoid-associated protein
OFO16_10210	COG3082	Protein of unknown function (DUF1414)
OFO16_10240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OFO16_10250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_10255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_10260	COG1120	ATPase activity
OFO16_10265	COG1522	sequence-specific DNA binding
OFO16_10270	COG0626	cystathionine gamma-synthase activity
OFO16_10275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_10280	COG0765	amino acid transport
OFO16_10290	COG0123	including yeast histone deacetylase and acetoin utilization protein
OFO16_10300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OFO16_10305	COG0778	Nitroreductase
OFO16_10310	COG3385	transposase activity
OFO16_10315	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFO16_10315	COG1902	pentaerythritol trinitrate reductase activity
OFO16_10320	COG0616	signal peptide processing
OFO16_10325	COG0252	asparaginase activity
OFO16_10330	COG3139	Protein of unknown function (DUF1315)
OFO16_10340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_10345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_10355	COG2226	methyltransferase
OFO16_10370	COG1785	Belongs to the alkaline phosphatase family
OFO16_10380	COG0668	transmembrane transport
OFO16_10390	COG2261	transglycosylase associated protein
OFO16_10400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OFO16_10405	COG3385	transposase activity
OFO16_10410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OFO16_10425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OFO16_10430	COG2832	Protein of unknown function (DUF454)
OFO16_10440	COG0745	RESPONSE REGULATOR receiver
OFO16_10445	COG0583	DNA-binding transcription factor activity
OFO16_10460	COG5492	domain, Protein
OFO16_10465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OFO16_10470	COG1286	toxin biosynthetic process
OFO16_10475	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
OFO16_10480	COG0285	dihydrofolate synthase activity
OFO16_10485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OFO16_10490	COG0101	tRNA pseudouridine synthase activity
OFO16_10500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OFO16_10505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OFO16_10510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OFO16_10520	COG0431	NADPH-dependent FMN reductase
OFO16_10530	COG3101	peptidyl-lysine hydroxylation
OFO16_10535	COG2860	membrane
OFO16_10540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OFO16_10545	COG2890	protein-(glutamine-N5) methyltransferase activity
OFO16_10550	COG2840	Smr protein MutS2
OFO16_10555	COG2062	phosphohistidine phosphatase, SixA
OFO16_10570	COG1024	Enoyl-CoA hydratase
OFO16_10570	COG1250	3-hydroxyacyl-CoA dehydrogenase
OFO16_10575	COG0183	Belongs to the thiolase family
OFO16_10615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OFO16_10620	COG1138	Cytochrome C-type biogenesis protein
OFO16_10625	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OFO16_10630	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFO16_10635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFO16_10640	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFO16_10645	COG4133	protoheme IX ABC transporter activity
OFO16_10655	COG0835	chemotaxis
OFO16_10665	COG1192	Involved in chromosome partitioning
OFO16_10670	COG2201	protein-glutamate methylesterase activity
OFO16_10675	COG0643	Histidine kinase
OFO16_10675	COG0784	Response regulator, receiver
OFO16_10675	COG2198	Histidine kinase
OFO16_10680	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
OFO16_10720	COG1987	bacterial-type flagellum assembly
OFO16_10770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OFO16_10780	COG1677	Flagellar hook-basal body complex protein FliE
OFO16_10800	COG1516	flagellar protein fliS
OFO16_10810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OFO16_10815	COG1334	flagellar protein FlaG
OFO16_10820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_10825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_10830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFO16_10835	COG2837	iron assimilation
OFO16_10865	COG1393	Belongs to the ArsC family
OFO16_10870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OFO16_10885	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
OFO16_10890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OFO16_10895	COG2716	regulation of RNA biosynthetic process
OFO16_10925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OFO16_10935	COG3547	Transposase (IS116 IS110 IS902 family)
OFO16_10945	COG3385	transposase activity
OFO16_10980	COG1462	curli production assembly transport component CsgG
OFO16_11010	COG3293	Transposase
OFO16_11015	COG3547	Transposase (IS116 IS110 IS902 family)
OFO16_11065	COG4783	chaperone-mediated protein folding
OFO16_11070	COG1393	Belongs to the ArsC family
OFO16_11090	COG2233	PERMEase
OFO16_11095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OFO16_11100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OFO16_11105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OFO16_11110	COG0121	glutamine amidotransferase
OFO16_11115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OFO16_11120	COG1960	acyl-CoA dehydrogenase activity
OFO16_11140	COG0328	RNA-DNA hybrid ribonuclease activity
OFO16_11145	COG2226	methyltransferase
OFO16_11150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OFO16_11155	COG0741	lytic transglycosylase activity
OFO16_11155	COG1388	LysM domain
OFO16_11165	COG3021	interspecies interaction between organisms
OFO16_11170	COG0347	Belongs to the P(II) protein family
OFO16_11180	COG0037	tRNA processing
OFO16_11185	COG0825	malonyl-CoA metabolic process
OFO16_11190	COG0587	DNA-directed DNA polymerase activity
OFO16_11200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_11205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_11215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFO16_11220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
OFO16_11230	COG0750	zinc metalloprotease
OFO16_11235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OFO16_11240	COG0575	Belongs to the CDS family
OFO16_11245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OFO16_11250	COG0233	cytoplasmic translational termination
OFO16_11255	COG0528	UMP kinase activity
OFO16_11260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OFO16_11270	COG0024	Methionine aminopeptidase
OFO16_11275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
OFO16_11285	COG0564	pseudouridine synthase activity
OFO16_11315	COG1671	Belongs to the UPF0178 family
OFO16_11320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OFO16_11330	COG0254	rRNA binding
OFO16_11335	COG1720	tRNA m6t6A37 methyltransferase activity
OFO16_11355	COG0733	neurotransmitter:sodium symporter activity
OFO16_11365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_11370	COG0514	ATP-dependent DNA helicase (RecQ)
OFO16_11375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OFO16_11385	COG2991	Protein conserved in bacteria
OFO16_11390	COG1477	protein flavinylation
OFO16_11395	COG2871	sodium ion transport
OFO16_11400	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_11405	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_11410	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_11415	COG1805	sodium ion transport
OFO16_11420	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFO16_11430	COG0271	Belongs to the BolA IbaG family
OFO16_11435	COG2813	Specifically methylates the guanine in position
OFO16_11460	COG1595	DNA-templated transcription, initiation
OFO16_11475	COG3248	Nucleoside-binding outer membrane protein
OFO16_11480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OFO16_11485	COG0693	protein deglycase activity
OFO16_11490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OFO16_11495	COG3706	GGDEF domain
OFO16_11500	COG2166	iron-sulfur cluster assembly
OFO16_11505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OFO16_11510	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
OFO16_11520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OFO16_11520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OFO16_11525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OFO16_11530	COG1074	ATP-dependent DNA helicase activity
OFO16_11535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OFO16_11565	COG3141	response to X-ray
OFO16_11570	COG2171	N-acyltransferase activity
OFO16_11575	COG0584	glycerophosphoryl diester phosphodiesterase
OFO16_11580	COG2271	Major facilitator Superfamily
OFO16_11585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OFO16_11590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OFO16_11595	COG1349	DNA-binding transcription factor activity
OFO16_11600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OFO16_11620	COG1609	Transcriptional regulator
OFO16_11625	COG1609	Transcriptional regulator
OFO16_11630	COG0583	DNA-binding transcription factor activity
OFO16_11700	COG4964	Belongs to the GSP D family
OFO16_11730	COG2169	Transcriptional regulator
OFO16_11735	COG1022	Amp-dependent synthetase and ligase
OFO16_11750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OFO16_11755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OFO16_11765	COG0560	Phosphoserine phosphatase
OFO16_11775	COG0813	purine-nucleoside phosphorylase activity
OFO16_11780	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OFO16_11785	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OFO16_11790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OFO16_11795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFO16_11800	COG0084	hydrolase, TatD family'
OFO16_11810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OFO16_11825	COG3153	acetyltransferase
OFO16_11830	COG3154	lipid carrier protein
OFO16_11840	COG0826	peptidase U32
OFO16_11845	COG0826	peptidase U32
OFO16_11850	COG0534	Mate efflux family protein
OFO16_11860	COG1185	polyribonucleotide nucleotidyltransferase activity
OFO16_11865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OFO16_11870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OFO16_11875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OFO16_11880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OFO16_11885	COG0195	Participates in both transcription termination and antitermination
OFO16_11890	COG0779	Required for maturation of 30S ribosomal subunits
OFO16_11905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OFO16_11915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OFO16_11920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OFO16_11925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OFO16_11930	COG1534	Rna-binding protein
OFO16_11935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_11940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
OFO16_11945	COG2027	D-alanyl-D-alanine carboxypeptidase
OFO16_11955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OFO16_11960	COG0739	heme binding
OFO16_11975	COG0316	Belongs to the HesB IscA family
OFO16_11980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OFO16_11985	COG0628	permease
OFO16_11990	COG2813	Specifically methylates the guanine in position
OFO16_11995	COG0784	Response regulator, receiver
OFO16_11995	COG2205	protein histidine kinase activity
OFO16_12000	COG0747	negative chemotaxis
OFO16_12010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_12015	COG0444	Belongs to the ABC transporter superfamily
OFO16_12020	COG4608	Belongs to the ABC transporter superfamily
OFO16_12030	COG2971	BadF BadG BcrA BcrD
OFO16_12045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OFO16_12050	COG3842	ATPase activity
OFO16_12060	COG1840	ABC-type Fe3 transport system, periplasmic component
OFO16_12065	COG0004	ammonium transporteR
OFO16_12075	COG3112	Uncharacterised protein family (UPF0231)
OFO16_12080	COG3835	regulator
OFO16_12085	COG2610	gluconate transmembrane transporter activity
OFO16_12090	COG1929	Belongs to the glycerate kinase type-1 family
OFO16_12095	COG1049	propionate catabolic process, 2-methylcitrate cycle
OFO16_12100	COG1752	Esterase of the alpha-beta hydrolase superfamily
OFO16_12105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OFO16_12110	COG1643	Atp-dependent helicase
OFO16_12115	COG1489	DNA binding
OFO16_12125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OFO16_12135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OFO16_12140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OFO16_12145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OFO16_12150	COG0842	Transport permease protein
OFO16_12155	COG1131	(ABC) transporter
OFO16_12160	COG0659	secondary active sulfate transmembrane transporter activity
OFO16_12165	COG0288	reversible hydration of carbon dioxide
OFO16_12170	COG3002	Belongs to the UPF0753 family
OFO16_12175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OFO16_12180	COG0583	DNA-binding transcription factor activity
OFO16_12195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFO16_12200	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFO16_12205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
OFO16_12210	COG2186	Transcriptional regulator
OFO16_12220	COG0157	Belongs to the NadC ModD family
OFO16_12225	COG4969	Belongs to the N-Me-Phe pilin family
OFO16_12230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFO16_12235	COG1459	type II secretion system
OFO16_12245	COG0237	dephospho-CoA kinase activity
OFO16_12250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
OFO16_12255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OFO16_12265	COG0336	Belongs to the RNA methyltransferase TrmD family
OFO16_12270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OFO16_12275	COG0228	four-way junction DNA binding
OFO16_12280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OFO16_12285	COG4137	Cytochrome C assembly protein
OFO16_12290	COG4536	flavin adenine dinucleotide binding
OFO16_12295	COG1854	S-ribosylhomocysteine lyase activity
OFO16_12305	COG2918	glutathione biosynthetic process
OFO16_12310	COG0612	Peptidase, M16
OFO16_12315	COG1238	metal cluster binding
OFO16_12325	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
OFO16_12330	COG5016	pyruvate
OFO16_12330	COG0511	ligase activity, forming carbon-carbon bonds
OFO16_12335	COG3630	sodium ion export across plasma membrane
OFO16_12400	COG0527	aspartate kinase activity
OFO16_12405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OFO16_12420	COG1546	Belongs to the CinA family
OFO16_12425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OFO16_12430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OFO16_12440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OFO16_12445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OFO16_12460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OFO16_12465	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OFO16_12470	COG0148	phosphopyruvate hydratase activity
OFO16_12475	COG0504	CTP synthase activity
OFO16_12480	COG3956	TIGRFAM MazG family protein
OFO16_12485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OFO16_12490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OFO16_12500	COG0736	holo-[acyl-carrier-protein] synthase activity
OFO16_12505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OFO16_12510	COG1381	Involved in DNA repair and RecF pathway recombination
OFO16_12515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OFO16_12530	COG0481	GTPase activity
OFO16_12535	COG3086	response to oxidative stress
OFO16_12550	COG1595	DNA-templated transcription, initiation
OFO16_12555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OFO16_12565	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OFO16_12570	COG0354	folic acid binding
OFO16_12585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_12590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFO16_12595	COG3079	Belongs to the UPF0149 family
OFO16_12600	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OFO16_12610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OFO16_12615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OFO16_12620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OFO16_12630	COG0583	DNA-binding transcription factor activity
OFO16_12635	COG1279	arginine transmembrane transporter activity
OFO16_12640	COG0668	transmembrane transport
OFO16_12645	COG0191	fructose-bisphosphate aldolase activity
OFO16_12650	COG0126	phosphoglycerate kinase activity
OFO16_12655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_12660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OFO16_12665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OFO16_12680	COG2356	endonuclease I
OFO16_12685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OFO16_12690	COG0189	ligase activity
OFO16_12695	COG1678	Uncharacterized ACR, COG1678
OFO16_12700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OFO16_12715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OFO16_12720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OFO16_12725	COG0762	integral membrane protein
OFO16_12740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OFO16_12745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OFO16_12750	COG2066	Belongs to the glutaminase family
OFO16_12770	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
OFO16_12775	COG0741	lytic transglycosylase activity
OFO16_12885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OFO16_12890	COG0300	oxidoreductase activity
OFO16_12930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_12935	COG0640	Transcriptional regulator
OFO16_12945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OFO16_12950	COG0573	inorganic phosphate transmembrane transporter activity
OFO16_12955	COG0581	inorganic phosphate transmembrane transporter activity
OFO16_12965	COG0704	Plays a role in the regulation of phosphate uptake
OFO16_12985	COG0798	PFAM Bile acid sodium symporter
OFO16_12990	COG0640	Transcriptional regulator
OFO16_13030	COG3293	Transposase
OFO16_13155	COG0300	oxidoreductase activity
OFO16_13170	COG0795	lipopolysaccharide-transporting ATPase activity
OFO16_13175	COG0795	lipopolysaccharide-transporting ATPase activity
OFO16_13180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OFO16_13185	COG2927	DNA polymerase III (CHI subunit)
OFO16_13190	COG0525	valine-tRNA ligase activity
OFO16_13215	COG2235	arginine
OFO16_13225	COG0540	Belongs to the ATCase OTCase family
OFO16_13230	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
OFO16_13235	COG0251	oxidation-reduction process
OFO16_13240	COG0204	Acyl-transferase
OFO16_13245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OFO16_13250	COG5007	Belongs to the BolA IbaG family
OFO16_13260	COG2854	intermembrane phospholipid transfer
OFO16_13265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OFO16_13270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OFO16_13275	COG1127	ABC transporter
OFO16_13285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OFO16_13285	COG0517	IMP dehydrogenase activity
OFO16_13295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OFO16_13300	COG1137	ATPase activity
OFO16_13310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OFO16_13315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_13320	COG1660	Displays ATPase and GTPase activities
OFO16_13325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_13330	COG2239	Acts as a magnesium transporter
OFO16_13335	COG0312	modulator of DNA gyrase
OFO16_13340	COG3028	Belongs to the UPF0307 family
OFO16_13345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OFO16_13350	COG0564	pseudouridine synthase activity
OFO16_13360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OFO16_13365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OFO16_13370	COG0312	modulator of DNA gyrase
OFO16_13375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OFO16_13380	COG3164	Protein of unknown function
OFO16_13390	COG0424	maF-like protein
OFO16_13395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OFO16_13400	COG1792	Involved in formation and maintenance of cell shape
OFO16_13405	COG1077	Cell shape determining protein MreB Mrl
OFO16_13440	COG2165	general secretion pathway protein
OFO16_13450	COG1459	type II secretion system
OFO16_13455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFO16_13465	COG3409	Peptidoglycan-binding domain 1 protein
OFO16_13465	COG3267	Type II secretory pathway component ExeA
OFO16_13490	COG2200	EAL domain
OFO16_13490	COG2199	diguanylate cyclase activity
OFO16_13495	COG0629	single-stranded DNA binding
OFO16_13510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OFO16_13520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OFO16_13525	COG0527	aspartate kinase activity
OFO16_13530	COG0646	methionine synthase
OFO16_13530	COG1410	methionine synthase
OFO16_13540	COG3385	transposase activity
OFO16_13565	COG0175	sulfate reduction
OFO16_13570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OFO16_13575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OFO16_13595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFO16_13600	COG0735	belongs to the Fur family
OFO16_13610	COG0166	Belongs to the GPI family
OFO16_13615	COG0432	Pfam Uncharacterised protein family UPF0047
OFO16_13620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OFO16_13645	COG2965	DNA replication, synthesis of RNA primer
OFO16_13650	COG0360	Binds together with S18 to 16S ribosomal RNA
OFO16_13655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OFO16_13660	COG0338	D12 class N6 adenine-specific DNA methyltransferase
OFO16_13670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OFO16_13675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OFO16_13705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OFO16_13715	COG0678	peroxiredoxin activity
OFO16_13715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OFO16_13720	COG0165	Argininosuccinate lyase
OFO16_13720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OFO16_13725	COG0137	argininosuccinate synthase activity
OFO16_13730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OFO16_13735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OFO16_13745	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OFO16_13755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OFO16_13760	COG0460	homoserine dehydrogenase
OFO16_13760	COG0527	aspartate kinase activity
OFO16_13765	COG0626	cystathionine gamma-synthase activity
OFO16_13775	COG0281	malic enzyme
OFO16_13795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OFO16_13815	COG2923	Belongs to the DsrF TusC family
OFO16_13820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OFO16_13825	COG2964	Protein conserved in bacteria
OFO16_13830	COG0545	Peptidyl-prolyl cis-trans isomerase
OFO16_13840	COG2900	Belongs to the SlyX family
OFO16_13850	COG1047	Peptidyl-prolyl cis-trans
OFO16_13865	COG2249	NAD(P)H dehydrogenase (quinone) activity
OFO16_13870	COG0488	(ABC) transporter
OFO16_13880	COG0429	hydrolase of the alpha beta-hydrolase fold
OFO16_13890	COG3954	Phosphoribulokinase
OFO16_13895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFO16_13905	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_13915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OFO16_13920	COG0512	Glutamine amidotransferase of anthranilate synthase
OFO16_13925	COG3385	transposase activity
OFO16_13930	COG0180	Tryptophanyl-tRNA synthetase
OFO16_13935	COG0546	phosphoglycolate phosphatase activity
OFO16_13940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFO16_13945	COG0557	exoribonuclease II activity
OFO16_13950	COG1959	2 iron, 2 sulfur cluster binding
OFO16_13955	COG1017	nitric oxide dioxygenase activity
OFO16_13955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_13960	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
OFO16_13970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OFO16_13975	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
OFO16_13980	COG0330	HflC and HflK could
OFO16_13985	COG0330	HflC and HflK could
OFO16_13990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OFO16_14000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OFO16_14005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OFO16_14010	COG0860	N-Acetylmuramoyl-L-alanine amidase
OFO16_14015	COG0802	atpase or kinase
OFO16_14020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OFO16_14085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OFO16_14090	COG1162	GTPase activity
OFO16_14100	COG0471	metal ion transport
OFO16_14100	COG3273	potassium ion transport
OFO16_14110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OFO16_14115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFO16_14125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OFO16_14130	COG1045	serine acetyltransferase
OFO16_14135	COG4942	peptidase
OFO16_14155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OFO16_14160	COG1053	succinate dehydrogenase
OFO16_14165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OFO16_14180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OFO16_14185	COG1509	lysine 2,3-aminomutase activity
OFO16_14215	COG0534	Mate efflux family protein
OFO16_14220	COG0205	6-phosphofructokinase activity
OFO16_14230	COG3678	ATP-independent chaperone mediated protein folding
OFO16_14235	COG0745	RESPONSE REGULATOR receiver
OFO16_14240	COG2205	protein histidine kinase activity
OFO16_14245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OFO16_14255	COG1027	Aspartate ammonia-lyase
OFO16_14260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OFO16_14265	COG4232	protein-disulfide reductase activity
OFO16_14275	COG3263	regulation of cellular component size
OFO16_14285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_14300	COG0784	Response regulator, receiver
OFO16_14300	COG2198	Histidine kinase
OFO16_14300	COG2205	protein histidine kinase activity
OFO16_14305	COG2814	Major facilitator Superfamily
OFO16_14320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFO16_14325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OFO16_14330	COG0511	ligase activity, forming carbon-carbon bonds
OFO16_14335	COG0439	Biotin carboxylase
OFO16_14340	COG2264	protein methyltransferase activity
OFO16_14345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFO16_14350	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OFO16_14435	COG3710	Transcriptional regulator
OFO16_14445	COG0138	bifunctional purine biosynthesis protein purh
OFO16_14450	COG0151	Belongs to the GarS family
OFO16_14465	COG1253	flavin adenine dinucleotide binding
OFO16_14470	COG3068	Protein conserved in bacteria
OFO16_14480	COG1573	uracil-dna glycosylase
OFO16_14485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OFO16_14490	COG2816	NAD+ diphosphatase activity
OFO16_14495	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
OFO16_14500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OFO16_14505	COG0085	RNA polymerase activity
OFO16_14510	COG0222	ribosome binding
OFO16_14515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OFO16_14530	COG0250	Participates in transcription elongation, termination and antitermination
OFO16_14535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OFO16_14575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OFO16_14585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OFO16_14660	COG4206	TonB-dependent receptor
OFO16_14680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFO16_14685	COG0534	Mate efflux family protein
OFO16_14690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
OFO16_14695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OFO16_14700	COG2937	Belongs to the GPAT DAPAT family
OFO16_14710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OFO16_14715	COG3161	chorismate lyase activity
OFO16_14720	COG1580	Controls the rotational direction of flagella during chemotaxis
OFO16_14725	COG0705	Rhomboid family
OFO16_14740	COG2177	Part of the ABC transporter FtsEX involved in
OFO16_14745	COG2884	Cell division ATP-binding protein ftsE
OFO16_14750	COG0552	protein localization to endoplasmic reticulum
OFO16_14755	COG0742	ribosomal rna small subunit methyltransferase
OFO16_14800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFO16_14805	COG0640	Transcriptional regulator
OFO16_14815	COG1280	lysine exporter protein (LysE YggA)
OFO16_14820	COG2267	carboxylic ester hydrolase activity
OFO16_14825	COG0561	phosphatase activity
OFO16_14840	COG3148	PFAM DTW domain containing protein
OFO16_14845	COG1011	Hydrolase
OFO16_14850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OFO16_14860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OFO16_14865	COG0019	diaminopimelate decarboxylase activity
OFO16_14875	COG1965	Belongs to the frataxin family
OFO16_14880	COG3072	Adenylate cyclase
OFO16_14885	COG0181	hydroxymethylbilane synthase activity
OFO16_14890	COG1587	Uroporphyrinogen-III synthase
OFO16_14895	COG2959	enzyme of heme biosynthesis
OFO16_14900	COG3071	HemY protein
OFO16_14945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OFO16_14960	COG3118	belongs to the thioredoxin family
OFO16_14965	COG0513	Belongs to the DEAD box helicase family
OFO16_14970	COG0248	Ppx GppA phosphatase
OFO16_14975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OFO16_14985	COG0514	ATP-dependent DNA helicase (RecQ)
OFO16_14990	COG2962	Rard protein
OFO16_15000	COG1280	lysine exporter protein (LysE YggA)
OFO16_15005	COG0405	Gamma-glutamyltransferase
OFO16_15010	COG0210	DNA helicase
OFO16_15020	COG3220	belongs to the UPF0276 family
OFO16_15040	COG2814	Major facilitator Superfamily
OFO16_15050	COG0006	proline dipeptidase activity
OFO16_15050	COG0006	proline dipeptidase activity
OFO16_15055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OFO16_15060	COG2022	thiamine diphosphate biosynthetic process
OFO16_15065	COG2104	thiamine diphosphate biosynthetic process
OFO16_15070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OFO16_15080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OFO16_15085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OFO16_15090	COG2132	Multicopper oxidase
OFO16_15140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OFO16_15150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OFO16_15155	COG0408	coproporphyrinogen oxidase activity
OFO16_15160	COG0009	L-threonylcarbamoyladenylate synthase
OFO16_15165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OFO16_15170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OFO16_15175	COG0551	DNA topoisomerase type I activity
OFO16_15180	COG2922	Belongs to the Smg family
OFO16_15185	COG0758	DNA mediated transformation
OFO16_15205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OFO16_15205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OFO16_15210	COG0569	domain protein
OFO16_15215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFO16_15225	COG1272	protein, Hemolysin III
OFO16_15230	COG4326	sporulation control protein
OFO16_15240	COG3084	Protein conserved in bacteria
OFO16_15250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OFO16_15255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_15260	COG0204	Acyl-transferase
OFO16_15285	COG0270	DNA (cytosine-5-)-methyltransferase activity
OFO16_15350	COG3978	acetolactate synthase activity
OFO16_15365	COG0583	DNA-binding transcription factor activity
OFO16_15370	COG2814	Major facilitator Superfamily
OFO16_15375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_15380	COG0765	amino acid transport
OFO16_15395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OFO16_15400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OFO16_15405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OFO16_15410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OFO16_15415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OFO16_15420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OFO16_15430	COG0356	it plays a direct role in the translocation of protons across the membrane
OFO16_15435	COG3312	ion transport
OFO16_15440	COG1475	DNA binding
OFO16_15445	COG1192	Involved in chromosome partitioning
OFO16_15455	COG0445	tRNA wobble uridine modification
OFO16_15460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OFO16_15470	COG0706	membrane insertase activity
OFO16_15480	COG0594	ribonuclease P activity
OFO16_15490	COG1126	abc transporter atp-binding protein
OFO16_15510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OFO16_15510	COG2111	Na H antiporter
OFO16_15515	COG1006	Multisubunit Na H antiporter MnhC subunit
OFO16_15520	COG0651	ATP synthesis coupled electron transport
OFO16_15525	COG1863	multisubunit Na H antiporter MnhE subunit
OFO16_15530	COG2212	antiporter activity
OFO16_15535	COG1320	monovalent cation:proton antiporter activity
OFO16_15550	COG0513	Belongs to the DEAD box helicase family
OFO16_15560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFO16_15670	COG3706	GGDEF domain
OFO16_15690	COG3550	peptidyl-serine autophosphorylation
OFO16_15700	COG1733	regulation of RNA biosynthetic process
OFO16_15710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OFO16_15735	COG0697	spore germination
OFO16_15740	COG5413	integral membrane protein
OFO16_15755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OFO16_15760	COG1960	acyl-CoA dehydrogenase activity
OFO16_15770	COG0183	Belongs to the thiolase family
OFO16_15780	COG1960	acyl-CoA dehydrogenase activity
OFO16_15785	COG1024	Enoyl-CoA hydratase
OFO16_15790	COG1024	Enoyl-CoA hydratase
OFO16_15800	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_15805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OFO16_15810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OFO16_15815	COG1845	cytochrome c oxidase, subunit III
OFO16_15820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OFO16_15825	COG0109	protoheme IX farnesyltransferase activity
OFO16_15830	COG1902	pentaerythritol trinitrate reductase activity
OFO16_15840	COG0531	amino acid
OFO16_15845	COG2040	homocysteine
OFO16_15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_15875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OFO16_15900	COG1126	abc transporter atp-binding protein
OFO16_15905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_15910	COG4215	(ABC) transporter
OFO16_15915	COG4160	amino acid transport
OFO16_15920	COG1115	amino acid carrier protein
OFO16_15955	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
OFO16_15965	COG0583	DNA-binding transcription factor activity
OFO16_15975	COG3344	reverse transcriptase
OFO16_15980	COG3344	reverse transcriptase
OFO16_15990	COG3293	Transposase
OFO16_16010	COG3383	formate dehydrogenase (NAD+) activity
OFO16_16020	COG0543	2 iron, 2 sulfur cluster binding
OFO16_16025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OFO16_16025	COG0574	Belongs to the PEP-utilizing enzyme family
OFO16_16040	COG0022	dehydrogenase e1 component
OFO16_16040	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFO16_16045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFO16_16060	COG4702	Belongs to the UPF0303 family
OFO16_16065	COG0673	inositol 2-dehydrogenase activity
OFO16_16070	COG1349	DNA-binding transcription factor activity
OFO16_16075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OFO16_16080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OFO16_16085	COG1882	Formate acetyltransferase
OFO16_16090	COG1349	DNA-binding transcription factor activity
OFO16_16130	COG0443	Heat shock 70 kDa protein
OFO16_16160	COG0814	amino acid
OFO16_16170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_16175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OFO16_16335	COG0509	glycine decarboxylation via glycine cleavage system
OFO16_16340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFO16_16350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OFO16_16360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_16375	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OFO16_16375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_16375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFO16_16380	COG1105	Belongs to the carbohydrate kinase PfkB family
OFO16_16385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_16385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFO16_16390	COG1609	Transcriptional regulator
OFO16_16405	COG0765	amino acid transport
OFO16_16410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_16415	COG0765	amino acid transport
OFO16_16420	COG1126	abc transporter atp-binding protein
OFO16_16430	COG1979	alcohol dehydrogenase
OFO16_16435	COG2207	Transcriptional regulator
OFO16_16445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OFO16_16450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OFO16_16455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_16470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_16475	COG0840	transmembrane signaling receptor activity
OFO16_16480	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
OFO16_16485	COG0513	Belongs to the DEAD box helicase family
OFO16_16490	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OFO16_16505	COG3038	cytochrome b561
OFO16_16510	COG2353	YceI-like domain
OFO16_16515	COG2116	formate transmembrane transporter activity
OFO16_16520	COG0583	DNA-binding transcription factor activity
OFO16_16530	COG3593	DNA synthesis involved in DNA repair
OFO16_16535	COG0737	Belongs to the 5'-nucleotidase family
OFO16_16540	COG0861	Integral membrane protein TerC family
OFO16_16550	COG3293	Transposase
OFO16_16560	COG2267	carboxylic ester hydrolase activity
OFO16_16565	COG2067	long-chain fatty acid transport protein
OFO16_16580	COG2050	protein possibly involved in aromatic compounds catabolism
OFO16_16600	COG1324	tolerance protein
OFO16_16625	COG3300	MHYT domain
OFO16_16625	COG5001	Diguanylate cyclase
OFO16_16630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OFO16_16640	COG4181	ATPase activity
OFO16_16645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OFO16_16740	COG1984	allophanate hydrolase subunit 2
OFO16_16745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_16750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_16755	COG3447	MASE1 domain protein
OFO16_16755	COG5002	protein histidine kinase activity
OFO16_16755	COG5001	Diguanylate cyclase
OFO16_16765	COG0583	DNA-binding transcription factor activity
OFO16_16770	COG1042	CoA-binding domain protein
OFO16_16770	COG0045	succinate-CoA ligase (ADP-forming) activity
OFO16_16770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFO16_16780	COG3385	transposase activity
OFO16_16785	COG1181	Belongs to the D-alanine--D-alanine ligase family
OFO16_16795	COG0023	Translation Initiation Factor
OFO16_16800	COG2801	Transposase and inactivated derivatives
OFO16_16820	COG3293	Transposase
OFO16_16825	COG3140	Belongs to the UPF0181 family
OFO16_16840	COG0745	RESPONSE REGULATOR receiver
OFO16_16850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
OFO16_16855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OFO16_16870	COG3706	GGDEF domain
OFO16_16875	COG5001	Diguanylate cyclase
OFO16_16875	COG2203	Gaf domain
OFO16_16875	COG3706	GGDEF domain
OFO16_16875	COG4251	negative regulation of phosphorylation
OFO16_16880	COG3335	DDE superfamily endonuclease
OFO16_16890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OFO16_16895	COG4149	molybdate abc transporter
OFO16_16900	COG0725	ABC transporter, periplasmic molybdate-binding protein
OFO16_16905	COG1492	cobalamin metabolic process
OFO16_16915	COG0189	ligase activity
OFO16_16915	COG4067	protein conserved in archaea
OFO16_16925	COG2207	Transcriptional regulator
OFO16_16930	COG0534	Mate efflux family protein
OFO16_16935	COG0602	queuosine metabolic process
OFO16_16940	COG1328	CTP reductase activity
OFO16_16990	COG0583	DNA-binding transcription factor activity
OFO16_16995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OFO16_17015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OFO16_17020	COG3118	belongs to the thioredoxin family
OFO16_17030	COG3385	transposase activity
OFO16_17050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OFO16_17070	COG2116	formate transmembrane transporter activity
OFO16_17080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OFO16_17085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFO16_17090	COG5001	Diguanylate cyclase
OFO16_17115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFO16_17115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_17165	COG0277	FAD linked oxidase domain protein
OFO16_17170	COG0583	DNA-binding transcription factor activity
OFO16_17180	COG2425	protein containing a von Willebrand factor type A (vWA) domain
OFO16_17195	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
OFO16_17210	COG3040	lipid binding
OFO16_17220	COG0702	epimerase
OFO16_17225	COG1733	regulation of RNA biosynthetic process
OFO16_17245	COG0419	ATPase involved in DNA repair
OFO16_17250	COG0420	3'-5' exonuclease activity
OFO16_17255	COG2130	NADP-dependent
OFO16_17260	COG1846	Transcriptional regulator
OFO16_17270	COG0745	RESPONSE REGULATOR receiver
OFO16_17275	COG2205	protein histidine kinase activity
OFO16_17305	COG3335	DDE superfamily endonuclease
OFO16_17310	COG3335	DDE superfamily endonuclease
OFO16_17315	COG4172	Belongs to the ABC transporter superfamily
OFO16_17320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_17325	COG0601	transmembrane transport
OFO16_17330	COG4166	transmembrane transport
OFO16_17345	COG0765	amino acid transport
OFO16_17350	COG0765	amino acid transport
OFO16_17360	COG1737	Transcriptional regulator
OFO16_17365	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_17370	COG4670	ketone body catabolic process
OFO16_17390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFO16_17425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
OFO16_17430	COG0069	glutamate synthase activity
OFO16_17445	COG3290	protein histidine kinase activity
OFO16_17455	COG0471	metal ion transport
OFO16_17460	COG3385	transposase activity
OFO16_17510	COG0589	response to stress
OFO16_17525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OFO16_17530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OFO16_17530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OFO16_17545	COG0356	it plays a direct role in the translocation of protons across the membrane
OFO16_17560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OFO16_17565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OFO16_17575	COG1214	PFAM Peptidase M22, glycoprotease
OFO16_17575	COG0456	acetyltransferase
OFO16_17590	COG3069	C4-dicarboxylate transmembrane transporter activity
OFO16_17595	COG1704	LemA family
OFO16_17600	COG0501	Belongs to the peptidase M48B family
OFO16_17610	COG2223	nitrite transmembrane transporter activity
OFO16_17620	COG1597	lipid kinase activity
OFO16_17650	COG0583	DNA-binding transcription factor activity
OFO16_17665	COG0784	Response regulator, receiver
OFO16_17665	COG2205	protein histidine kinase activity
OFO16_17665	COG2198	Histidine kinase
OFO16_17670	COG1879	ABC-type sugar transport system periplasmic component
OFO16_17675	COG1803	Methylglyoxal synthase
OFO16_17680	COG0210	DNA helicase
OFO16_17685	COG1289	transmembrane transporter activity
OFO16_17700	COG0789	Transcriptional regulator
OFO16_17705	COG1609	Transcriptional regulator
OFO16_17710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_17715	COG1879	ABC-type sugar transport system periplasmic component
OFO16_17720	COG1172	Belongs to the binding-protein-dependent transport system permease family
OFO16_17725	COG1129	ABC transporter
OFO16_17730	COG1869	D-ribose catabolic process
OFO16_17735	COG5001	Diguanylate cyclase
OFO16_17785	COG0583	DNA-binding transcription factor activity
OFO16_17790	COG5002	protein histidine kinase activity
OFO16_17795	COG0745	RESPONSE REGULATOR receiver
OFO16_17810	COG2916	Histone family protein nucleoid-structuring protein H-NS
OFO16_17835	COG2205	protein histidine kinase activity
OFO16_17850	COG0582	viral genome integration into host DNA
OFO16_17890	COG1278	Cold shock
OFO16_17895	COG4628	conserved protein (DUF2132)
OFO16_17905	COG3335	DDE superfamily endonuclease
OFO16_17915	COG1280	lysine exporter protein (LysE YggA)
OFO16_17920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFO16_17935	COG3265	gluconokinase activity
OFO16_18065	COG0243	molybdopterin cofactor binding
OFO16_18070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OFO16_18070	COG1648	precorrin-2 dehydrogenase activity
OFO16_18075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OFO16_18085	COG2223	nitrite transmembrane transporter activity
OFO16_18090	COG0515	serine threonine protein kinase
OFO16_18090	COG2815	serine threonine protein kinase
OFO16_18095	COG2197	response regulator
OFO16_18100	COG2207	Transcriptional regulator
OFO16_18145	COG0330	HflC and HflK could
OFO16_18150	COG0517	IMP dehydrogenase activity
OFO16_18150	COG4175	Glycine betaine
OFO16_18155	COG4176	ABC-type proline glycine betaine transport system permease component
OFO16_18170	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_18175	COG1309	transcriptional regulator
OFO16_18180	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_18195	COG1024	Enoyl-CoA hydratase
OFO16_18200	COG1960	acyl-CoA dehydrogenase activity
OFO16_18210	COG0183	Belongs to the thiolase family
OFO16_18220	COG1960	acyl-CoA dehydrogenase activity
OFO16_18225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OFO16_18230	COG1024	Enoyl-CoA hydratase
OFO16_18235	COG4770	biotin carboxylase activity
OFO16_18270	COG4948	Mandelate Racemase Muconate Lactonizing
OFO16_18295	COG0583	DNA-binding transcription factor activity
OFO16_18305	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
OFO16_18305	COG3264	Mechanosensitive ion channel
OFO16_18315	COG3474	cytochrome
OFO16_18320	COG3293	Transposase
OFO16_18385	COG2205	protein histidine kinase activity
OFO16_18385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_18420	COG2814	Major facilitator Superfamily
OFO16_18430	COG0840	transmembrane signaling receptor activity
OFO16_18440	COG2814	Major facilitator Superfamily
OFO16_18450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OFO16_18465	COG1355	regulation of microtubule-based process
OFO16_18490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OFO16_18490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OFO16_18495	COG2610	gluconate transmembrane transporter activity
OFO16_18500	COG3622	Belongs to the hyi family
OFO16_18505	COG0235	Class ii aldolase
OFO16_18510	COG3395	kinase activity
OFO16_18515	COG2084	Dehydrogenase
OFO16_18520	COG1349	DNA-binding transcription factor activity
OFO16_18525	COG0656	L-ascorbic acid biosynthetic process
OFO16_18530	COG0402	S-adenosylhomocysteine deaminase activity
OFO16_18560	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_18595	COG0667	Aldo Keto reductase
OFO16_18600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OFO16_18610	COG0583	DNA-binding transcription factor activity
OFO16_18630	COG0579	oxidoreductase
OFO16_18645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OFO16_18655	COG4771	TonB-dependent receptor
OFO16_18665	COG0583	DNA-binding transcription factor activity
OFO16_18670	COG2814	Major facilitator Superfamily
OFO16_18675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_18715	COG1757	Na H antiporter
OFO16_18760	COG3706	GGDEF domain
OFO16_18785	COG3850	Histidine kinase
OFO16_18785	COG3437	response regulator, receiver
OFO16_18785	COG2205	protein histidine kinase activity
OFO16_18785	COG4999	Histidine kinase
OFO16_18810	COG0582	viral genome integration into host DNA
OFO16_18815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OFO16_18850	COG3293	Transposase
OFO16_18875	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OFO16_18880	COG2731	YhcH YjgK YiaL family protein
OFO16_18885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OFO16_18895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_18900	COG1414	Transcriptional regulator
OFO16_18905	COG0800	Aldolase
OFO16_18910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_18915	COG1917	Cupin 2, conserved barrel domain protein
OFO16_18955	COG0246	Mannitol dehydrogenase
OFO16_18965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_18970	COG2186	Transcriptional regulator
OFO16_18980	COG3181	Tripartite tricarboxylate transporter family receptor
OFO16_19040	COG2186	Transcriptional regulator
OFO16_19045	COG2186	Transcriptional regulator
OFO16_19050	COG0517	IMP dehydrogenase activity
OFO16_19055	COG2176	DNA-directed DNA polymerase activity
OFO16_19060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_19085	COG0516	GMP reductase activity
OFO16_19090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OFO16_19090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OFO16_19095	COG4989	oxidoreductase activity
OFO16_19110	COG0038	chloride channel
OFO16_19130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OFO16_19140	COG2897	thiosulfate sulfurtransferase activity
OFO16_19150	COG2358	TRAP transporter, solute receptor (TAXI family
OFO16_19160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OFO16_19165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OFO16_19170	COG0840	transmembrane signaling receptor activity
OFO16_19175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFO16_19185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_19195	COG0840	transmembrane signaling receptor activity
OFO16_19215	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFO16_19230	COG2197	response regulator
OFO16_19235	COG3850	Histidine kinase
OFO16_19240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFO16_19240	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFO16_19250	COG0243	molybdopterin cofactor binding
OFO16_19260	COG3005	denitrification pathway
OFO16_19280	COG0183	Belongs to the thiolase family
OFO16_19290	COG1280	lysine exporter protein (LysE YggA)
OFO16_19295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_19300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFO16_19350	COG0784	Response regulator, receiver
OFO16_19350	COG2205	protein histidine kinase activity
OFO16_19355	COG1879	ABC-type sugar transport system periplasmic component
OFO16_19365	COG3132	Protein of unknown function, DUF480
OFO16_19385	COG0673	inositol 2-dehydrogenase activity
OFO16_19410	COG1522	sequence-specific DNA binding
OFO16_19415	COG0531	amino acid
OFO16_19430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OFO16_19435	COG2239	Acts as a magnesium transporter
OFO16_19440	COG1418	mRNA catabolic process
OFO16_19460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OFO16_19465	COG3385	transposase activity
OFO16_19480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFO16_19495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OFO16_19500	COG2194	sulfuric ester hydrolase activity
OFO16_19505	COG0673	inositol 2-dehydrogenase activity
OFO16_19510	COG3304	Inner membrane component domain
OFO16_19525	COG4667	esterase of the alpha-beta hydrolase superfamily
OFO16_19530	COG1741	Belongs to the pirin family
OFO16_19535	COG1278	Cold shock
OFO16_19550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OFO16_19570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OFO16_19590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
OFO16_19650	COG0625	glutathione transferase activity
OFO16_19660	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_19695	COG0513	Belongs to the DEAD box helicase family
OFO16_19705	COG0583	DNA-binding transcription factor activity
OFO16_19720	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_19730	COG2723	6-phospho-beta-galactosidase activity
OFO16_19735	COG1263	PTS System
OFO16_19735	COG2190	(PTS) system
OFO16_19735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_19740	COG2723	6-phospho-beta-galactosidase activity
OFO16_19745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_19750	COG1609	Transcriptional regulator
OFO16_19755	COG0006	proline dipeptidase activity
OFO16_19760	COG3608	succinylglutamate desuccinylase aspartoacylase
OFO16_19765	COG1522	sequence-specific DNA binding
OFO16_19770	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_19775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_19780	COG3122	Protein conserved in bacteria
OFO16_19785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OFO16_19790	COG2986	histidine ammonia-lyase
OFO16_19820	COG1309	transcriptional regulator
OFO16_19855	COG2233	PERMEase
OFO16_19865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFO16_19885	COG1278	Cold shock
OFO16_19890	COG0557	exoribonuclease II activity
OFO16_19905	COG2188	Transcriptional regulator
OFO16_19915	COG0697	spore germination
OFO16_19925	COG0583	DNA-binding transcription factor activity
OFO16_19930	COG2814	Major facilitator Superfamily
OFO16_19935	COG4566	intracellular signal transduction
OFO16_19940	COG4191	Histidine kinase
OFO16_19945	COG0318	PFAM AMP-dependent synthetase and ligase
OFO16_19950	COG0659	secondary active sulfate transmembrane transporter activity
OFO16_19955	COG0583	DNA-binding transcription factor activity
OFO16_19960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OFO16_19965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OFO16_19970	COG0574	Belongs to the PEP-utilizing enzyme family
OFO16_19970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OFO16_19985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OFO16_19990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFO16_20005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_20020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_20050	COG3842	ATPase activity
OFO16_20080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OFO16_20135	COG1342	Belongs to the UPF0251 family
OFO16_20140	COG3015	lipoprotein NlpE involved in copper resistance
OFO16_20145	COG0583	DNA-binding transcription factor activity
OFO16_20150	COG0697	spore germination
OFO16_20165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OFO16_20175	COG1335	isochorismatase
OFO16_20190	COG0531	amino acid
OFO16_20195	COG4302	ethanolamine ammonia-lyase activity
OFO16_20200	COG4303	Ethanolamine ammonia lyase large subunit
OFO16_20210	COG1309	transcriptional regulator
OFO16_20230	COG1280	lysine exporter protein (LysE YggA)
OFO16_20235	COG0459	protein refolding
OFO16_20240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OFO16_20245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFO16_20270	COG1304	FMN binding
OFO16_20285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OFO16_20305	COG1760	l-serine dehydratase
OFO16_20310	COG0583	DNA-binding transcription factor activity
OFO16_20320	COG2866	Carboxypeptidase
OFO16_20325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_20345	COG3842	ATPase activity
OFO16_20355	COG3385	transposase activity
OFO16_20360	COG1840	ABC-type Fe3 transport system, periplasmic component
OFO16_20370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_20390	COG3240	lipase activity
OFO16_20400	COG0577	efflux transmembrane transporter activity
OFO16_20400	COG1136	(ABC) transporter
OFO16_20405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_20420	COG1011	Hydrolase
OFO16_20430	COG3152	Membrane
OFO16_20440	COG1765	OsmC-like protein
OFO16_20445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_20445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFO16_20460	COG3046	protein related to deoxyribodipyrimidine photolyase
OFO16_20465	COG3706	GGDEF domain
OFO16_20505	COG3385	transposase activity
OFO16_20510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFO16_20525	COG0579	oxidoreductase
OFO16_20540	COG3706	GGDEF domain
OFO16_20560	COG0189	ligase activity
OFO16_20565	COG4067	protein conserved in archaea
OFO16_20565	COG0189	ligase activity
OFO16_20575	COG1166	arginine decarboxylase activity
OFO16_20580	COG0010	Belongs to the arginase family
OFO16_20585	COG3293	Transposase
OFO16_20590	COG2814	Major facilitator Superfamily
OFO16_20595	COG1770	oligopeptidase
OFO16_20615	COG0848	biopolymer transport protein
OFO16_20620	COG0811	peptide transport
OFO16_20625	COG0811	peptide transport
OFO16_20640	COG2205	protein histidine kinase activity
OFO16_20645	COG0745	RESPONSE REGULATOR receiver
OFO16_20650	COG0039	L-malate dehydrogenase activity
OFO16_20655	COG0584	glycerophosphoryl diester phosphodiesterase
OFO16_20665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OFO16_20730	COG1901	pseudouridine methyltransferase
OFO16_20735	COG0312	modulator of DNA gyrase
OFO16_20740	COG0312	modulator of DNA gyrase
OFO16_20745	COG0351	phosphomethylpyrimidine kinase
OFO16_20750	COG1116	anion transmembrane transporter activity
OFO16_20755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OFO16_20760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OFO16_20765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OFO16_20785	COG0243	molybdopterin cofactor binding
OFO16_20790	COG3005	denitrification pathway
OFO16_20805	COG1929	Belongs to the glycerate kinase type-1 family
OFO16_20815	COG3835	regulator
OFO16_20855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OFO16_20870	COG3047	cAMP biosynthetic process
OFO16_20895	COG2375	cellular response to nickel ion
OFO16_20900	COG0800	Aldolase
OFO16_20905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFO16_20920	COG1028	Short-chain dehydrogenase reductase Sdr
OFO16_20930	COG0583	DNA-binding transcription factor activity
OFO16_20945	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OFO16_20965	COG0561	phosphatase activity
OFO16_20970	COG0583	DNA-binding transcription factor activity
OFO16_20980	COG0564	pseudouridine synthase activity
OFO16_20985	COG0534	Mate efflux family protein
OFO16_20990	COG5001	Diguanylate cyclase
OFO16_21000	COG3123	guanosine phosphorylase activity
OFO16_21035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OFO16_21040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OFO16_21045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OFO16_21055	COG2259	Doxx family
OFO16_21060	COG1741	Belongs to the pirin family
OFO16_21080	COG0363	glucosamine-6-phosphate deaminase activity
OFO16_21105	COG1131	(ABC) transporter
OFO16_21115	COG0786	glutamate:sodium symporter activity
OFO16_21125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OFO16_21130	COG3279	Response regulator of the LytR AlgR family
OFO16_21135	COG3275	phosphorelay sensor kinase activity
OFO16_21150	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFO16_21155	COG1136	(ABC) transporter
OFO16_21205	COG1444	tRNA N-acetyltransferase activity
OFO16_21260	COG0259	pyridoxamine-phosphate oxidase activity
OFO16_21285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFO16_21305	COG3293	Transposase
OFO16_21320	COG3119	arylsulfatase activity
OFO16_21325	COG3119	arylsulfatase activity
OFO16_21330	COG3634	alkyl hydroperoxide reductase activity
OFO16_21340	COG1846	Transcriptional regulator
OFO16_21345	COG1764	response to oxidative stress
OFO16_21360	COG0577	efflux transmembrane transporter activity
OFO16_21365	COG1136	(ABC) transporter
OFO16_21370	COG4221	oxidoreductase activity
OFO16_21380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OFO16_21385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFO16_21390	COG4521	taurine ABC transporter
OFO16_21395	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OFO16_21400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OFO16_21410	COG2211	Major facilitator Superfamily
OFO16_21415	COG3940	Belongs to the glycosyl hydrolase 43 family
OFO16_21420	COG2017	converts alpha-aldose to the beta-anomer
OFO16_21430	COG3335	DDE superfamily endonuclease
OFO16_21435	COG2160	L-arabinose isomerase activity
OFO16_21445	COG1069	ribulokinase activity
OFO16_21450	COG1879	ABC-type sugar transport system periplasmic component
OFO16_21455	COG1129	ABC transporter
OFO16_21460	COG1172	Belongs to the binding-protein-dependent transport system permease family
OFO16_21470	COG4772	TonB-dependent receptor
OFO16_21475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OFO16_21490	COG0642	Histidine kinase
OFO16_21495	COG1653	transport
OFO16_21500	COG3119	arylsulfatase activity
OFO16_21520	COG2423	ornithine cyclodeaminase activity
OFO16_21530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_21570	COG0583	DNA-binding transcription factor activity
OFO16_21590	COG3171	Protein conserved in bacteria
OFO16_21605	COG0814	amino acid
OFO16_21610	COG3033	Beta-eliminating lyase
OFO16_21640	COG4604	ABC transporter, ATP-binding protein
OFO16_21645	COG4605	iron ion homeostasis
OFO16_21650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFO16_21655	COG4607	ABC-type enterochelin transport system periplasmic component
OFO16_21660	COG0583	DNA-binding transcription factor activity
OFO16_21665	COG4771	TonB-dependent receptor
OFO16_21670	COG2814	Major facilitator Superfamily
OFO16_21680	COG1263	PTS System
OFO16_21680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_21710	COG0366	Alpha amylase catalytic
OFO16_21725	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
OFO16_21730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
OFO16_21735	COG1162	GTPase activity
OFO16_21740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFO16_21740	COG1263	PTS System
OFO16_21745	COG1999	signal sequence binding
OFO16_21760	COG2909	trisaccharide binding
OFO16_21765	COG0058	SHG alpha-glucan phosphorylase activity
OFO16_21770	COG1640	4-alpha-glucanotransferase
OFO16_21775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OFO16_21780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OFO16_21785	COG0366	Alpha amylase catalytic
OFO16_21790	COG3339	Conserved Protein
OFO16_21795	COG1301	dicarboxylic acid transport
OFO16_21810	COG2095	MarC family integral membrane protein
OFO16_21815	COG4667	esterase of the alpha-beta hydrolase superfamily
OFO16_21820	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
OFO16_21825	COG1054	Belongs to the UPF0176 family
OFO16_21840	COG1686	Belongs to the peptidase S11 family
OFO16_21845	COG4628	conserved protein (DUF2132)
OFO16_21855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_21860	COG3385	transposase activity
OFO16_21865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OFO16_21900	COG3293	Transposase
OFO16_21935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OFO16_21980	COG0745	RESPONSE REGULATOR receiver
OFO16_22005	COG3300	MHYT domain
OFO16_22005	COG5001	Diguanylate cyclase
OFO16_22010	COG0156	8-amino-7-oxononanoate synthase activity
OFO16_22015	COG1063	alcohol dehydrogenase
OFO16_22025	COG1278	Cold shock
OFO16_22040	COG0668	transmembrane transport
OFO16_22050	COG1304	FMN binding
OFO16_22055	COG1620	l-lactate permease
OFO16_22060	COG0583	DNA-binding transcription factor activity
OFO16_22065	COG1505	serine-type exopeptidase activity
OFO16_22075	COG1067	ATP-dependent peptidase activity
OFO16_22095	COG1247	-acetyltransferase
OFO16_22100	COG0437	4 iron, 4 sulfur cluster binding
OFO16_22105	COG0348	domain, Protein
OFO16_22115	COG4720	Psort location CytoplasmicMembrane, score
OFO16_22120	COG1566	PFAM secretion protein HlyD family protein
OFO16_22130	COG3706	GGDEF domain
OFO16_22145	COG0813	purine-nucleoside phosphorylase activity
OFO16_22150	COG3272	Protein of unknown function (DUF1722)
OFO16_22155	COG0789	Transcriptional regulator
OFO16_22160	COG0415	Belongs to the DNA photolyase family
OFO16_22165	COG1376	ErfK ybiS ycfS ynhG family protein
OFO16_22165	COG1388	LysM domain
OFO16_22175	COG0513	Belongs to the DEAD box helicase family
OFO16_22190	COG0573	inorganic phosphate transmembrane transporter activity
OFO16_22195	COG0581	inorganic phosphate transmembrane transporter activity
OFO16_22200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OFO16_22210	COG2304	oxidoreductase activity
OFO16_22230	COG0714	Associated with various cellular activities
OFO16_22240	COG3385	transposase activity
OFO16_22285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFO16_22300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OFO16_22305	COG1120	ATPase activity
OFO16_22310	COG4774	siderophore transport
OFO16_22315	COG1132	(ABC) transporter
OFO16_22320	COG0583	DNA-binding transcription factor activity
OFO16_22335	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_22350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_22360	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
OFO16_22365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_22370	COG2084	Dehydrogenase
OFO16_22380	COG2130	NADP-dependent
OFO16_22385	COG1309	transcriptional regulator
OFO16_22390	COG3097	Belongs to the UPF0267 family
OFO16_22420	COG0438	transferase activity, transferring glycosyl groups
OFO16_22445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OFO16_22450	COG3842	ATPase activity
OFO16_22460	COG1175	transmembrane transport
OFO16_22465	COG3833	ABC-type maltose transport systems, permease component
OFO16_22505	COG3344	reverse transcriptase
OFO16_22540	COG3344	reverse transcriptase
OFO16_22550	COG3344	reverse transcriptase
OFO16_22555	COG4999	Histidine kinase
OFO16_22555	COG3850	Histidine kinase
OFO16_22555	COG3437	response regulator, receiver
OFO16_22555	COG2205	protein histidine kinase activity
OFO16_22575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_22610	COG0741	lytic transglycosylase activity
OFO16_22620	COG1522	sequence-specific DNA binding
OFO16_22630	COG1448	Aminotransferase
OFO16_22640	COG3385	transposase activity
OFO16_22665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_22670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OFO16_22675	COG1984	allophanate hydrolase subunit 2
OFO16_22695	COG0071	Belongs to the small heat shock protein (HSP20) family
OFO16_22720	COG1609	Transcriptional regulator
OFO16_22735	COG0395	ABC-type sugar transport system, permease component
OFO16_22740	COG2723	6-phospho-beta-galactosidase activity
OFO16_22745	COG3842	ATPase activity
OFO16_22750	COG1609	Transcriptional regulator
OFO16_22760	COG0747	negative chemotaxis
OFO16_22770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFO16_22775	COG0444	Belongs to the ABC transporter superfamily
OFO16_22780	COG4608	Belongs to the ABC transporter superfamily
OFO16_22790	COG1609	Transcriptional regulator
OFO16_22810	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_22835	COG2176	DNA-directed DNA polymerase activity
OFO16_22845	COG2354	Protein conserved in bacteria
OFO16_22850	COG0418	dihydroorotase activity
OFO16_22860	COG3217	Mosc domain protein beta barrel domain protein
OFO16_22860	COG0633	Ferredoxin
OFO16_22860	COG3217	Mosc domain protein beta barrel domain protein
OFO16_22860	COG0633	Ferredoxin
OFO16_22865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OFO16_22870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OFO16_22905	COG0748	coenzyme F420 binding
OFO16_22910	COG0835	chemotaxis
OFO16_22910	COG0784	Response regulator, receiver
OFO16_22915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFO16_22935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OFO16_22950	COG1063	alcohol dehydrogenase
OFO16_22955	COG0583	DNA-binding transcription factor activity
OFO16_22970	COG1902	pentaerythritol trinitrate reductase activity
OFO16_22985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OFO16_22990	COG4948	Mandelate Racemase Muconate Lactonizing
OFO16_23000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OFO16_23025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFO16_23035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_23045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_23055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OFO16_23065	COG1979	alcohol dehydrogenase
OFO16_23070	COG0366	Alpha amylase catalytic
OFO16_23085	COG1472	Belongs to the glycosyl hydrolase 3 family
OFO16_23100	COG2249	NAD(P)H dehydrogenase (quinone) activity
OFO16_23105	COG0589	response to stress
OFO16_23110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFO16_23130	COG2871	sodium ion transport
OFO16_23140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFO16_23160	COG3383	formate dehydrogenase (NAD+) activity
OFO16_23170	COG0842	Transport permease protein
OFO16_23175	COG1131	(ABC) transporter
OFO16_23190	COG0798	PFAM Bile acid sodium symporter
OFO16_23225	COG0814	amino acid
OFO16_23245	COG3314	Sporulation integral membrane protein YlbJ
OFO16_23265	COG0739	heme binding
OFO16_23270	COG5001	Diguanylate cyclase
OFO16_23275	COG0583	DNA-binding transcription factor activity
OFO16_23300	COG0179	Fumarylacetoacetate (FAA) hydrolase
OFO16_23320	COG1280	lysine exporter protein (LysE YggA)
OFO16_23325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OFO16_23340	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OFO16_23345	COG1845	cytochrome c oxidase, subunit III
OFO16_23370	COG0109	protoheme IX farnesyltransferase activity
OFO16_23375	COG0545	Peptidyl-prolyl cis-trans isomerase
OFO16_23405	COG1278	Cold shock
OFO16_23435	COG0577	efflux transmembrane transporter activity
OFO16_23435	COG1136	(ABC) transporter
OFO16_23450	COG0783	Belongs to the Dps family
OFO16_23460	COG2133	pyrroloquinoline quinone binding
OFO16_23465	COG1454	alcohol dehydrogenase
OFO16_23470	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
OFO16_23490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFO16_23495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFO16_23500	COG3186	Phenylalanine-4-hydroxylase
OFO16_23525	COG3530	Putative quorum-sensing-regulated virulence factor
OFO16_23535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFO16_23560	COG0789	Transcriptional regulator
OFO16_23565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OFO16_23570	COG0133	tryptophan synthase activity
OFO16_23580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
OFO16_23585	COG0523	cobalamin synthesis protein
OFO16_23590	COG0513	Belongs to the DEAD box helicase family
OFO16_23605	COG2200	EAL domain
OFO16_23610	COG1119	ATPase activity
OFO16_23635	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFO16_23635	COG1902	pentaerythritol trinitrate reductase activity
OFO16_23640	COG2181	nitrate reductase activity
OFO16_23640	COG0247	lactate metabolic process
OFO16_23645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OFO16_23655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFO16_23665	COG0656	L-ascorbic acid biosynthetic process
OFO16_23675	COG1012	belongs to the aldehyde dehydrogenase family
OFO16_23680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_23700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFO16_23710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFO16_23715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFO16_23730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OFO16_23730	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFO16_23745	COG1760	l-serine dehydratase
OFO16_23760	COG1064	alcohol dehydrogenase
OFO16_23765	COG1979	alcohol dehydrogenase
OFO16_23770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OFO16_23775	COG1085	galactose-1-phosphate uridylyltransferase
OFO16_23785	COG3385	transposase activity
OFO16_23830	COG1070	Carbohydrate kinase
OFO16_23840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFO16_23860	COG2855	membrane
OFO16_23875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFO16_23880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFO16_23885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFO16_23890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFO16_23890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFO16_23900	COG1414	Transcriptional regulator
OFO16_23905	COG0280	phosphate acetyltransferase
OFO16_23910	COG0730	response to heat
OFO16_23935	COG0644	oxidoreductase
OFO16_23970	COG1953	Uracil, thiamine, allantoin
OFO16_23975	COG0590	tRNA wobble adenosine to inosine editing
OFO16_23990	COG3335	DDE superfamily endonuclease
OFO16_24010	COG0583	DNA-binding transcription factor activity
OFO16_24015	COG2807	transmembrane transport
OFO16_24030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OFO16_24035	COG1304	FMN binding
OFO16_24040	COG0549	Belongs to the carbamate kinase family
OFO16_24090	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
OFO16_24095	COG0589	response to stress