locus-tag	class	description
I3X05_00010	COG0592	DNA-directed DNA polymerase activity
I3X05_00020	COG0187	DNA topoisomerase II activity
I3X05_00025	COG0071	Belongs to the small heat shock protein (HSP20) family
I3X05_00030	COG3977	Valine--pyruvate aminotransferase
I3X05_00035	COG0751	glycine-tRNA ligase activity
I3X05_00040	COG0752	glycyl-tRNA synthetase alpha subunit
I3X05_00045	COG2119	membrane
I3X05_00085	COG0604	alcohol dehydrogenase
I3X05_00090	COG0183	Belongs to the thiolase family
I3X05_00100	COG1739	Uncharacterized protein family UPF0029
I3X05_00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3X05_00110	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I3X05_00170	COG0583	DNA-binding transcription factor activity
I3X05_00175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3X05_00180	COG2960	long-chain fatty acid transporting porin activity
I3X05_00185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3X05_00190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3X05_00195	COG1309	transcriptional regulator
I3X05_00235	COG4172	Belongs to the ABC transporter superfamily
I3X05_00240	COG4166	transmembrane transport
I3X05_00245	COG0601	transmembrane transport
I3X05_00250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3X05_00285	COG0515	serine threonine protein kinase
I3X05_00285	COG2815	serine threonine protein kinase
I3X05_00300	COG1609	Transcriptional regulator
I3X05_00305	COG0129	dihydroxy-acid dehydratase activity
I3X05_00310	COG3265	gluconokinase activity
I3X05_00315	COG2610	gluconate transmembrane transporter activity
I3X05_00320	COG0800	Aldolase
I3X05_00325	COG2814	Major facilitator Superfamily
I3X05_00340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3X05_00345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I3X05_00355	COG1522	sequence-specific DNA binding
I3X05_00360	COG5001	Diguanylate cyclase
I3X05_00360	COG5002	protein histidine kinase activity
I3X05_00380	COG0589	response to stress
I3X05_00385	COG1528	Iron-storage protein
I3X05_00395	COG2081	HI0933 family
I3X05_00410	COG5433	transposase activity
I3X05_00450	COG1322	Protein conserved in bacteria
I3X05_00455	COG2226	methyltransferase
I3X05_00465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3X05_00475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3X05_00480	COG0805	protein transport
I3X05_00485	COG0084	hydrolase, TatD family'
I3X05_00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3X05_00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3X05_00525	COG3078	GTPase activator activity
I3X05_00540	COG2203	Gaf domain
I3X05_00540	COG5001	Diguanylate cyclase
I3X05_00540	COG4251	negative regulation of phosphorylation
I3X05_00540	COG3706	GGDEF domain
I3X05_00545	COG2204	response regulator
I3X05_00550	COG3852	Histidine kinase
I3X05_00560	COG0174	glutamine synthetase
I3X05_00565	COG1217	gtp-binding protein TYPA
I3X05_00570	COG1295	ribonuclease BN
I3X05_00575	COG1490	D-aminoacyl-tRNA deacylase activity
I3X05_00580	COG0456	acetyltransferase
I3X05_00595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I3X05_00600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I3X05_00605	COG3031	protein transport across the cell outer membrane
I3X05_00615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3X05_00620	COG1459	type II secretion system
I3X05_00625	COG2165	general secretion pathway protein
I3X05_00630	COG2165	general secretion pathway protein
I3X05_00635	COG2165	general secretion pathway protein
I3X05_00640	COG4795	General secretion pathway protein
I3X05_00645	COG3156	type II secretion system protein K
I3X05_00650	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I3X05_00655	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I3X05_00665	COG1218	3'(2'),5'-bisphosphate nucleotidase
I3X05_00670	COG0494	nUDIX hydrolase
I3X05_00675	COG0316	Belongs to the HesB IscA family
I3X05_00675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I3X05_00680	COG1040	competence protein
I3X05_00695	COG2183	response to ionizing radiation
I3X05_00715	COG1129	ABC transporter
I3X05_00720	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3X05_00725	COG1472	Belongs to the glycosyl hydrolase 3 family
I3X05_00745	COG2233	PERMEase
I3X05_00750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3X05_00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3X05_00760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3X05_00765	COG1758	RNA polymerase activity
I3X05_00770	COG0194	GDP metabolic process
I3X05_00785	COG0848	biopolymer transport protein
I3X05_00790	COG0811	peptide transport
I3X05_00795	COG0811	peptide transport
I3X05_00810	COG4174	ABC transporter (Permease)
I3X05_00815	COG4239	(ABC) transporter, permease
I3X05_00820	COG0747	negative chemotaxis
I3X05_00825	COG0444	Belongs to the ABC transporter superfamily
I3X05_00830	COG4608	Belongs to the ABC transporter superfamily
I3X05_00860	COG1561	YicC-like family, N-terminal region
I3X05_00865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3X05_00875	COG1560	Kdo2-lipid A biosynthetic process
I3X05_00880	COG1309	transcriptional regulator
I3X05_00885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I3X05_00890	COG0840	transmembrane signaling receptor activity
I3X05_00895	COG2003	Belongs to the UPF0758 family
I3X05_00900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3X05_00905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3X05_00915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3X05_00925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3X05_00930	COG0438	transferase activity, transferring glycosyl groups
I3X05_00935	COG0463	Glycosyl transferase, family 2
I3X05_00940	COG0859	PFAM glycosyl transferase family 9
I3X05_00945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3X05_00950	COG3642	lipopolysaccharide core region biosynthetic process
I3X05_01030	COG0277	FAD linked oxidase domain protein
I3X05_01035	COG4221	oxidoreductase activity
I3X05_01045	COG1519	Transferase
I3X05_01050	COG0859	PFAM glycosyl transferase family 9
I3X05_01060	COG1560	Kdo2-lipid A biosynthetic process
I3X05_01080	COG1404	Belongs to the peptidase S8 family
I3X05_01105	COG1596	polysaccharide export
I3X05_01120	COG3206	protein involved in exopolysaccharide biosynthesis
I3X05_01120	COG0489	protein tyrosine kinase activity
I3X05_01125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3X05_01130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I3X05_01140	COG0110	maltose O-acetyltransferase activity
I3X05_01160	COG1086	Polysaccharide biosynthesis protein
I3X05_01185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3X05_01190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3X05_01200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I3X05_01230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3X05_01235	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
I3X05_01245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3X05_01250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3X05_01255	COG0149	triose-phosphate isomerase activity
I3X05_01275	COG1494	fructose-1,6-bisphosphatase
I3X05_01280	COG3074	FtsZ-dependent cytokinesis
I3X05_01290	COG1575	Belongs to the MenA family. Type 1 subfamily
I3X05_01295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I3X05_01300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I3X05_01310	COG1609	Transcriptional regulator
I3X05_01315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3X05_01325	COG0281	malic enzyme
I3X05_01330	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I3X05_01335	COG0626	cystathionine gamma-synthase activity
I3X05_01340	COG0527	aspartate kinase activity
I3X05_01340	COG0460	homoserine dehydrogenase
I3X05_01345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3X05_01355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3X05_01360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3X05_01365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3X05_01375	COG0137	argininosuccinate synthase activity
I3X05_01380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3X05_01380	COG0165	Argininosuccinate lyase
I3X05_01395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I3X05_01425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3X05_01430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3X05_01440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I3X05_01445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3X05_01450	COG0360	Binds together with S18 to 16S ribosomal RNA
I3X05_01465	COG0359	binds to the 23S rRNA
I3X05_01480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3X05_01495	COG0166	Belongs to the GPI family
I3X05_01505	COG0735	belongs to the Fur family
I3X05_01540	COG0175	sulfate reduction
I3X05_01615	COG3344	reverse transcriptase
I3X05_01645	COG1438	arginine binding
I3X05_01650	COG0039	L-malate dehydrogenase activity
I3X05_01660	COG0142	geranyltranstransferase activity
I3X05_01665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3X05_01670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3X05_01675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3X05_01680	COG2966	Psort location CytoplasmicMembrane, score
I3X05_01685	COG3610	response to peptide
I3X05_01700	COG2967	ApaG domain
I3X05_01705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3X05_01710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I3X05_01735	COG0066	3-isopropylmalate dehydratase activity
I3X05_01745	COG0473	3-isopropylmalate dehydrogenase activity
I3X05_01750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3X05_01755	COG1309	transcriptional regulator
I3X05_01775	COG1022	Amp-dependent synthetase and ligase
I3X05_01780	COG0028	Belongs to the TPP enzyme family
I3X05_01785	COG0440	acetolactate synthase activity
I3X05_01790	COG3706	GGDEF domain
I3X05_01795	COG1802	Transcriptional regulator
I3X05_01805	COG1349	DNA-binding transcription factor activity
I3X05_01815	COG3722	fumarate hydratase activity
I3X05_01825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3X05_01825	COG2213	PTS system mannitol-specific
I3X05_01830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I3X05_01875	COG0358	DNA primase activity
I3X05_01880	COG1610	YqeY-like protein
I3X05_01885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I3X05_01890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3X05_01905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3X05_01910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I3X05_01915	COG1968	undecaprenyl-diphosphatase activity
I3X05_01920	COG0617	tRNA 3'-terminal CCA addition
I3X05_01925	COG3267	Type II secretory pathway component ExeA
I3X05_01925	COG3409	Peptidoglycan-binding domain 1 protein
I3X05_01930	COG4991	sh3 domain protein
I3X05_01935	COG0306	phosphate transporter
I3X05_01940	COG1392	Phosphate transport regulator
I3X05_01945	COG3025	triphosphatase activity
I3X05_01950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3X05_01960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3X05_01970	COG1538	Outer membrane efflux protein
I3X05_01975	COG0494	nUDIX hydrolase
I3X05_01980	COG3151	Protein conserved in bacteria
I3X05_01990	COG3150	esterase
I3X05_02005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3X05_02010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3X05_02015	COG3105	Protein conserved in bacteria
I3X05_02020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I3X05_02025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3X05_02030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3X05_02035	COG0723	plastoquinol--plastocyanin reductase activity
I3X05_02040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3X05_02045	COG2857	Cytochrome c1
I3X05_02050	COG0625	glutathione transferase activity
I3X05_02055	COG2969	positive regulation of protein catabolic process
I3X05_02065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3X05_02070	COG0792	nuclease activity
I3X05_02075	COG3107	peptidoglycan biosynthetic process
I3X05_02080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I3X05_02090	COG0275	rRNA processing
I3X05_02095	COG3116	cell division
I3X05_02100	COG0768	penicillin binding
I3X05_02110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3X05_02115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3X05_02125	COG0772	Belongs to the SEDS family
I3X05_02140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3X05_02145	COG0849	cell division
I3X05_02150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3X05_02155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I3X05_02160	COG0653	protein targeting
I3X05_02165	COG0494	nUDIX hydrolase
I3X05_02175	COG0505	Belongs to the CarA family
I3X05_02180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3X05_02185	COG0730	response to heat
I3X05_02190	COG0583	DNA-binding transcription factor activity
I3X05_02195	COG2860	membrane
I3X05_02200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3X05_02205	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3X05_02210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3X05_02220	COG0493	'glutamate synthase
I3X05_02225	COG0070	glutamate synthase
I3X05_02225	COG0067	glutamate synthase
I3X05_02225	COG0069	glutamate synthase activity
I3X05_02235	COG0069	glutamate synthase activity
I3X05_02235	COG0070	glutamate synthase
I3X05_02235	COG0067	glutamate synthase
I3X05_02240	COG1242	4 iron, 4 sulfur cluster binding
I3X05_02245	COG3706	GGDEF domain
I3X05_02245	COG5001	Diguanylate cyclase
I3X05_02245	COG2203	Gaf domain
I3X05_02245	COG4251	negative regulation of phosphorylation
I3X05_02250	COG2198	Histidine kinase
I3X05_02250	COG0784	Response regulator, receiver
I3X05_02250	COG5002	protein histidine kinase activity
I3X05_02260	COG0745	RESPONSE REGULATOR receiver
I3X05_02270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I3X05_02285	COG0083	homoserine kinase activity
I3X05_02290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3X05_02295	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I3X05_02305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3X05_02320	COG1115	amino acid carrier protein
I3X05_02325	COG3022	response to hydroperoxide
I3X05_02330	COG0513	Belongs to the DEAD box helicase family
I3X05_02335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3X05_02350	COG4974	Belongs to the 'phage' integrase family
I3X05_02355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3X05_02360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I3X05_02370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3X05_02375	COG2204	response regulator
I3X05_02385	COG0667	Aldo Keto reductase
I3X05_02395	COG3066	DNA modification
I3X05_02400	COG0494	nUDIX hydrolase
I3X05_02410	COG0730	response to heat
I3X05_02425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I3X05_02450	COG3550	peptidyl-serine autophosphorylation
I3X05_02480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3X05_02485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3X05_02495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3X05_02515	COG4974	Belongs to the 'phage' integrase family
I3X05_02530	COG1283	sodium-dependent phosphate transmembrane transporter activity
I3X05_02535	COG0583	DNA-binding transcription factor activity
I3X05_02540	COG0640	Transcriptional regulator
I3X05_02545	COG0268	Binds directly to 16S ribosomal RNA
I3X05_02550	COG0728	peptidoglycan biosynthetic process
I3X05_02555	COG0196	riboflavin kinase activity
I3X05_02560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3X05_02565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3X05_02570	COG1047	Peptidyl-prolyl cis-trans
I3X05_02575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3X05_02585	COG3275	phosphorelay sensor kinase activity
I3X05_02590	COG1966	Carbon starvation protein
I3X05_02600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I3X05_02605	COG1472	Belongs to the glycosyl hydrolase 3 family
I3X05_02615	COG0287	Prephenate dehydrogenase
I3X05_02615	COG1605	Chorismate mutase
I3X05_02620	COG0739	heme binding
I3X05_02630	COG0488	(ABC) transporter
I3X05_02640	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I3X05_02645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I3X05_02650	COG0077	Prephenate dehydratase
I3X05_02650	COG1605	Chorismate mutase
I3X05_02655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3X05_02660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3X05_02730	COG3335	DDE superfamily endonuclease
I3X05_02735	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I3X05_02740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3X05_02745	COG0826	peptidase U32
I3X05_02755	COG0745	RESPONSE REGULATOR receiver
I3X05_02760	COG5002	protein histidine kinase activity
I3X05_02770	COG0248	Ppx GppA phosphatase
I3X05_02785	COG0581	inorganic phosphate transmembrane transporter activity
I3X05_02790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3X05_02795	COG0704	Plays a role in the regulation of phosphate uptake
I3X05_02810	COG0450	alkyl hydroperoxide reductase
I3X05_02815	COG0583	DNA-binding transcription factor activity
I3X05_02820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3X05_02830	COG0517	IMP dehydrogenase activity
I3X05_02840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3X05_02845	COG0343	queuine tRNA-ribosyltransferase activity
I3X05_02850	COG1862	Preprotein translocase
I3X05_02855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3X05_02860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3X05_02865	COG0483	inositol monophosphate 1-phosphatase activity
I3X05_02870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I3X05_02875	COG1959	2 iron, 2 sulfur cluster binding
I3X05_02880	COG1104	cysteine desulfurase activity
I3X05_02885	COG0822	iron-sulfur transferase activity
I3X05_02890	COG0316	Belongs to the HesB IscA family
I3X05_02895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I3X05_02900	COG0443	Heat shock 70 kDa protein
I3X05_02905	COG0633	Ferredoxin
I3X05_02910	COG2975	iron-sulfur cluster assembly
I3X05_02915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3X05_02920	COG0105	UTP biosynthetic process
I3X05_02930	COG1426	Protein conserved in bacteria
I3X05_02935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3X05_02940	COG0124	histidyl-tRNA synthetase
I3X05_02945	COG2976	Protein conserved in bacteria
I3X05_02950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3X05_02955	COG1160	GTP binding
I3X05_02960	COG2199	diguanylate cyclase activity
I3X05_02960	COG2203	Gaf domain
I3X05_02975	COG0516	GMP reductase activity
I3X05_02975	COG0517	IMP dehydrogenase activity
I3X05_02980	COG0519	Catalyzes the synthesis of GMP from XMP
I3X05_02980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3X05_02995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3X05_03000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3X05_03040	COG1584	GPR1 FUN34 yaaH family protein
I3X05_03045	COG1115	amino acid carrier protein
I3X05_03055	COG0583	DNA-binding transcription factor activity
I3X05_03070	COG0009	L-threonylcarbamoyladenylate synthase
I3X05_03085	COG0697	spore germination
I3X05_03120	COG2433	Pfam Transposase IS66
I3X05_03170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3X05_03175	COG2867	negative regulation of translational initiation
I3X05_03180	COG2914	Belongs to the UPF0125 (RnfH) family
I3X05_03185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3X05_03190	COG0497	DNA recombination
I3X05_03200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3X05_03220	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I3X05_03230	COG0443	Heat shock 70 kDa protein
I3X05_03235	COG0484	heat shock protein binding
I3X05_03265	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3X05_03275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3X05_03280	COG0583	DNA-binding transcription factor activity
I3X05_03285	COG0590	tRNA wobble adenosine to inosine editing
I3X05_03295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I3X05_03320	COG2195	Cleaves the N-terminal amino acid of tripeptides
I3X05_03325	COG2252	PERMEase
I3X05_03330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I3X05_03335	COG1073	alpha beta
I3X05_03345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3X05_03350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3X05_03355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3X05_03360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3X05_03360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3X05_03375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3X05_03380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3X05_03390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I3X05_03395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3X05_03400	COG0142	geranyltranstransferase activity
I3X05_03405	COG1722	exodeoxyribonuclease VII activity
I3X05_03415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I3X05_03420	COG1360	Flagellar Motor Protein
I3X05_03425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3X05_03425	COG0301	tRNA thio-modification
I3X05_03430	COG0583	DNA-binding transcription factor activity
I3X05_03440	COG2363	Small membrane protein
I3X05_03455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3X05_03460	COG1611	Belongs to the LOG family
I3X05_03475	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I3X05_03475	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I3X05_03485	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I3X05_03490	COG1464	Belongs to the NlpA lipoprotein family
I3X05_03495	COG2011	ABC-type metal ion transport system permease component
I3X05_03505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3X05_03510	COG1609	Transcriptional regulator
I3X05_03515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3X05_03515	COG1263	PTS System
I3X05_03520	COG0366	Alpha amylase catalytic
I3X05_03540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3X05_03550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3X05_03555	COG0321	lipoyl(octanoyl) transferase activity
I3X05_03560	COG2921	Belongs to the UPF0250 family
I3X05_03565	COG1686	Belongs to the peptidase S11 family
I3X05_03570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3X05_03575	COG0772	Belongs to the SEDS family
I3X05_03580	COG0768	penicillin binding
I3X05_03585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I3X05_03590	COG0799	negative regulation of ribosome biogenesis
I3X05_03595	COG1466	dna polymerase III delta subunit
I3X05_03600	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I3X05_03610	COG2888	peptidyl-tyrosine sulfation
I3X05_03620	COG4535	Mg2 and Co2 transporter CorC
I3X05_03625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3X05_03630	COG1702	phosphate starvation-inducible protein PhoH
I3X05_03635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3X05_03640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3X05_03730	COG0012	GTP binding
I3X05_03735	COG0193	aminoacyl-tRNA hydrolase activity
I3X05_03740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3X05_03750	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I3X05_03760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3X05_03765	COG2890	protein-(glutamine-N5) methyltransferase activity
I3X05_03775	COG2912	Transglutaminase-like superfamily
I3X05_03780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I3X05_03790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3X05_03800	COG2840	Smr protein MutS2
I3X05_03830	COG2608	mercury ion transmembrane transporter activity
I3X05_03830	COG2217	Heavy metal translocating P-type atpase
I3X05_03900	COG0784	Response regulator, receiver
I3X05_03900	COG0835	chemotaxis
I3X05_03905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I3X05_03910	COG3344	reverse transcriptase
I3X05_03915	COG1815	bacterial-type flagellum-dependent cell motility
I3X05_03935	COG4787	bacterial-type flagellum-dependent cell motility
I3X05_03950	COG1706	bacterial-type flagellum-dependent cell motility
I3X05_03955	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3X05_03955	COG3951	Flagellar rod assembly protein muramidase FlgJ
I3X05_03965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3X05_03970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3X05_03975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3X05_03980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3X05_03985	COG2190	(PTS) system
I3X05_03995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3X05_04000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3X05_04005	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I3X05_04015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3X05_04035	COG0330	HflC and HflK could
I3X05_04040	COG3118	belongs to the thioredoxin family
I3X05_04045	COG0300	oxidoreductase activity
I3X05_04050	COG1090	epimerase
I3X05_04075	COG0622	Phosphoesterase
I3X05_04095	COG3710	Transcriptional regulator
I3X05_04100	COG0326	Molecular chaperone. Has ATPase activity
I3X05_04110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3X05_04115	COG3104	oligopeptide transport
I3X05_04125	COG0367	asparagine synthase
I3X05_04135	COG1940	carbohydrate kinase activity
I3X05_04135	COG1846	Transcriptional regulator
I3X05_04140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3X05_04145	COG2190	(PTS) system
I3X05_04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3X05_04145	COG1263	PTS System
I3X05_04150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3X05_04165	COG0583	DNA-binding transcription factor activity
I3X05_04170	COG1380	Effector of murein hydrolase LrgA
I3X05_04175	COG1346	cytolysis
I3X05_04180	COG0716	FMN binding
I3X05_04190	COG0596	Alpha beta hydrolase
I3X05_04195	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I3X05_04200	COG0033	Phosphoglucomutase
I3X05_04210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3X05_04225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I3X05_04230	COG1053	succinate dehydrogenase
I3X05_04240	COG0567	Dehydrogenase, E1 component
I3X05_04245	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3X05_04260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3X05_04265	COG1121	(ABC) transporter
I3X05_04270	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I3X05_04280	COG1918	ferrous iron import across plasma membrane
I3X05_04285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I3X05_04305	COG3102	Protein conserved in bacteria
I3X05_04310	COG0788	formyltetrahydrofolate deformylase activity
I3X05_04320	COG1199	ATP-dependent helicase activity
I3X05_04325	COG1214	PFAM Peptidase M22, glycoprotease
I3X05_04340	COG2267	carboxylic ester hydrolase activity
I3X05_04345	COG0318	PFAM AMP-dependent synthetase and ligase
I3X05_04350	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I3X05_04355	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I3X05_04360	COG2894	cell division
I3X05_04365	COG0850	regulation of cytokinetic process
I3X05_04370	COG3100	YcgL domain-containing protein
I3X05_04375	COG2951	lytic endotransglycosylase activity
I3X05_04380	COG0583	DNA-binding transcription factor activity
I3X05_04385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3X05_04400	COG1028	Short-chain dehydrogenase reductase Sdr
I3X05_04435	COG2986	histidine ammonia-lyase
I3X05_04440	COG1216	Glycosyl transferase, family 2
I3X05_04460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3X05_04465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3X05_04520	COG1175	transmembrane transport
I3X05_04525	COG0395	ABC-type sugar transport system, permease component
I3X05_04530	COG3842	ATPase activity
I3X05_04540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3X05_04545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3X05_04550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I3X05_04560	COG4191	Histidine kinase
I3X05_04575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3X05_04580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3X05_04585	COG0776	regulation of translation
I3X05_04590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3X05_04610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3X05_04615	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I3X05_04620	COG0436	Aminotransferase
I3X05_04625	COG1169	isochorismate synthase
I3X05_04630	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I3X05_04635	COG0596	Alpha beta hydrolase
I3X05_04640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3X05_04665	COG0477	Major facilitator Superfamily
I3X05_04705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3X05_04720	COG1522	sequence-specific DNA binding
I3X05_04730	COG1946	Acyl-CoA thioesterase
I3X05_04750	COG2203	Gaf domain
I3X05_04750	COG2199	diguanylate cyclase activity
I3X05_04795	COG4935	Belongs to the peptidase S8 family
I3X05_04795	COG1404	Belongs to the peptidase S8 family
I3X05_04820	COG0617	tRNA 3'-terminal CCA addition
I3X05_04820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I3X05_04820	COG0517	IMP dehydrogenase activity
I3X05_04830	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I3X05_04845	COG0537	adenosine 5'-monophosphoramidase activity
I3X05_04875	COG1252	NADH dehydrogenase
I3X05_04880	COG1054	Belongs to the UPF0176 family
I3X05_04895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I3X05_04905	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3X05_04910	COG1136	(ABC) transporter
I3X05_04915	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3X05_04925	COG0658	competence protein
I3X05_04925	COG2333	competence protein COMEC
I3X05_04930	COG1132	(ABC) transporter
I3X05_04935	COG1663	tetraacyldisaccharide 4'-kinase activity
I3X05_04940	COG2835	tetraacyldisaccharide 4'-kinase activity
I3X05_04945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I3X05_04950	COG2199	diguanylate cyclase activity
I3X05_04955	COG2719	SpoVR family
I3X05_04960	COG2718	Belongs to the UPF0229 family
I3X05_04965	COG2766	serine protein kinase
I3X05_04970	COG3013	Belongs to the UPF0304 family
I3X05_04980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3X05_04985	COG0840	transmembrane signaling receptor activity
I3X05_04995	COG1882	Formate acetyltransferase
I3X05_05020	COG4215	(ABC) transporter
I3X05_05025	COG4160	amino acid transport
I3X05_05030	COG0708	Exodeoxyribonuclease III
I3X05_05035	COG0840	transmembrane signaling receptor activity
I3X05_05045	COG3923	Primosomal replication protein n
I3X05_05055	COG1199	ATP-dependent helicase activity
I3X05_05060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3X05_05065	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I3X05_05080	COG1278	Cold shock
I3X05_05090	COG0542	response to heat
I3X05_05095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3X05_05100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I3X05_05115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3X05_05125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3X05_05130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3X05_05135	COG0297	glycogen (starch) synthase activity
I3X05_05155	COG3070	regulator of competence-specific genes
I3X05_05160	COG1609	Transcriptional regulator
I3X05_05165	COG3381	protein complex oligomerization
I3X05_05170	COG0745	RESPONSE REGULATOR receiver
I3X05_05175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3X05_05180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3X05_05190	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I3X05_05195	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I3X05_05215	COG0189	ligase activity
I3X05_05215	COG4067	protein conserved in archaea
I3X05_05220	COG0500	methyltransferase
I3X05_05230	COG1801	Protein of unknown function DUF72
I3X05_05245	COG0840	transmembrane signaling receptor activity
I3X05_05250	COG0632	four-way junction helicase activity
I3X05_05255	COG2255	four-way junction helicase activity
I3X05_05260	COG1271	oxidase subunit
I3X05_05265	COG1294	oxidase, subunit
I3X05_05270	COG4890	Cyd operon protein YbgT
I3X05_05280	COG0824	Thioesterase
I3X05_05285	COG0811	peptide transport
I3X05_05300	COG0823	Involved in the tonB-independent uptake of proteins
I3X05_05305	COG2885	chlorophyll binding
I3X05_05310	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I3X05_05315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3X05_05320	COG0137	argininosuccinate synthase activity
I3X05_05325	COG3766	membrane
I3X05_05335	COG0754	glutathionylspermidine amidase activity
I3X05_05350	COG1858	cytochrome C peroxidase
I3X05_05370	COG0784	Response regulator, receiver
I3X05_05370	COG5002	protein histidine kinase activity
I3X05_05385	COG0582	viral genome integration into host DNA
I3X05_05420	COG0210	DNA helicase
I3X05_05445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3X05_05450	COG4804	nuclease activity
I3X05_05455	COG0732	type I restriction modification DNA specificity domain
I3X05_05460	COG2433	Pfam Transposase IS66
I3X05_05485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I3X05_05520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I3X05_05530	COG0840	transmembrane signaling receptor activity
I3X05_05535	COG4628	conserved protein (DUF2132)
I3X05_05595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3X05_05610	COG1858	cytochrome C peroxidase
I3X05_05625	COG0415	Belongs to the DNA photolyase family
I3X05_05635	COG2203	Gaf domain
I3X05_05635	COG2199	diguanylate cyclase activity
I3X05_05685	COG0583	DNA-binding transcription factor activity
I3X05_05700	COG2350	Protein conserved in bacteria
I3X05_05720	COG1301	dicarboxylic acid transport
I3X05_05725	COG0159	tryptophan synthase activity
I3X05_05730	COG0133	tryptophan synthase activity
I3X05_05735	COG0135	phosphoribosylanthranilate isomerase activity
I3X05_05735	COG0134	indole-3-glycerol-phosphate synthase activity
I3X05_05745	COG0512	Glutamine amidotransferase of anthranilate synthase
I3X05_05750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3X05_05760	COG0613	PHP domain protein
I3X05_05765	COG0009	L-threonylcarbamoyladenylate synthase
I3X05_05780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3X05_05790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3X05_05795	COG0417	DNA replication proofreading
I3X05_05800	COG2197	response regulator
I3X05_05805	COG0322	excinuclease ABC activity
I3X05_05875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3X05_05880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3X05_05900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3X05_05925	COG2989	Protein conserved in bacteria
I3X05_05930	COG3108	Peptidase M15
I3X05_05935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3X05_05950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I3X05_05975	COG1846	Transcriptional regulator
I3X05_05980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3X05_05985	COG0840	transmembrane signaling receptor activity
I3X05_06005	COG1448	Aminotransferase
I3X05_06010	COG2770	Histidine kinase
I3X05_06010	COG3437	response regulator, receiver
I3X05_06015	COG0840	transmembrane signaling receptor activity
I3X05_06025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3X05_06035	COG0017	Asparaginyl-tRNA synthetase
I3X05_06045	COG0720	synthase
I3X05_06055	COG1136	(ABC) transporter
I3X05_06055	COG0577	efflux transmembrane transporter activity
I3X05_06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3X05_06065	COG1760	l-serine dehydratase
I3X05_06070	COG0814	amino acid
I3X05_06075	COG0494	nUDIX hydrolase
I3X05_06095	COG3106	COG3106 Predicted ATPase
I3X05_06100	COG3768	UPF0283 membrane protein
I3X05_06110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3X05_06125	COG0471	metal ion transport
I3X05_06130	COG4191	Histidine kinase
I3X05_06130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3X05_06135	COG2204	response regulator
I3X05_06140	COG3706	GGDEF domain
I3X05_06145	COG3300	MHYT domain
I3X05_06145	COG5001	Diguanylate cyclase
I3X05_06160	COG5001	Diguanylate cyclase
I3X05_06160	COG3300	MHYT domain
I3X05_06165	COG1328	CTP reductase activity
I3X05_06170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3X05_06195	COG0814	amino acid
I3X05_06205	COG0783	Belongs to the Dps family
I3X05_06220	COG1132	(ABC) transporter
I3X05_06225	COG1132	(ABC) transporter
I3X05_06245	COG3568	Endonuclease Exonuclease Phosphatase
I3X05_06270	COG1280	lysine exporter protein (LysE YggA)
I3X05_06275	COG0443	Heat shock 70 kDa protein
I3X05_06280	COG0443	Heat shock 70 kDa protein
I3X05_06340	COG4964	Belongs to the GSP D family
I3X05_06350	COG2894	cell division
I3X05_06390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3X05_06395	COG1643	Atp-dependent helicase
I3X05_06420	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I3X05_06430	COG2814	Major facilitator Superfamily
I3X05_06435	COG0010	Belongs to the arginase family
I3X05_06440	COG1166	arginine decarboxylase activity
I3X05_06495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3X05_06500	COG0072	phenylalanine-tRNA ligase activity
I3X05_06500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3X05_06505	COG2200	EAL domain
I3X05_06525	COG0776	regulation of translation
I3X05_06530	COG3344	reverse transcriptase
I3X05_06540	COG0500	methyltransferase
I3X05_06545	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I3X05_06550	COG0295	cytidine deaminase activity
I3X05_06555	COG1346	cytolysis
I3X05_06560	COG1380	Effector of murein hydrolase LrgA
I3X05_06565	COG2925	Exonuclease
I3X05_06570	COG0582	viral genome integration into host DNA
I3X05_06590	COG3081	Nucleoid-associated protein
I3X05_06650	COG1484	DNA-dependent DNA replication
I3X05_06830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3X05_06850	COG2988	succinylglutamate desuccinylase activity
I3X05_06860	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I3X05_06890	COG1451	nucleotide metabolic process
I3X05_06905	COG3063	Type IV pilus biogenesis stability protein PilW
I3X05_06915	COG0243	molybdopterin cofactor binding
I3X05_06925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3X05_06930	COG3707	response regulator
I3X05_06935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3X05_06935	COG1116	anion transmembrane transporter activity
I3X05_06940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3X05_06945	COG1116	anion transmembrane transporter activity
I3X05_06950	COG2146	nitrite reductase [NAD(P)H] activity
I3X05_06950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3X05_06955	COG2146	nitrite reductase [NAD(P)H] activity
I3X05_06970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3X05_06980	COG0625	glutathione transferase activity
I3X05_07010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3X05_07030	COG1278	Cold shock
I3X05_07045	COG0730	response to heat
I3X05_07070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3X05_07075	COG0372	Belongs to the citrate synthase family
I3X05_07080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3X05_07085	COG2828	Protein conserved in bacteria
I3X05_07105	COG0561	phosphatase activity
I3X05_07110	COG0602	queuosine metabolic process
I3X05_07115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I3X05_07120	COG3706	GGDEF domain
I3X05_07295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I3X05_07305	COG1254	Belongs to the acylphosphatase family
I3X05_07310	COG2920	part of a sulfur-relay system
I3X05_07315	COG0670	Belongs to the BI1 family
I3X05_07320	COG1126	abc transporter atp-binding protein
I3X05_07325	COG0765	amino acid transport
I3X05_07330	COG4597	amino acid ABC transporter
I3X05_07335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3X05_07350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3X05_07375	COG2996	Protein conserved in bacteria
I3X05_07380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I3X05_07380	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I3X05_07385	COG3008	intermembrane lipid transfer
I3X05_07390	COG2995	paraquat-inducible protein a
I3X05_07395	COG1132	(ABC) transporter
I3X05_07400	COG1956	GAF domain-containing protein
I3X05_07405	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I3X05_07420	COG0308	aminopeptidase N
I3X05_07435	COG0167	dihydroorotate dehydrogenase activity
I3X05_07445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I3X05_07445	COG0116	Belongs to the methyltransferase superfamily
I3X05_07455	COG0488	(ABC) transporter
I3X05_07470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I3X05_07475	COG1067	ATP-dependent peptidase activity
I3X05_07480	COG3120	sequence-specific DNA binding
I3X05_07580	COG0784	Response regulator, receiver
I3X05_07580	COG2205	protein histidine kinase activity
I3X05_07595	COG3278	Belongs to the heme-copper respiratory oxidase family
I3X05_07610	COG2010	Cytochrome c
I3X05_07620	COG2217	Heavy metal translocating P-type atpase
I3X05_07635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3X05_07640	COG0589	response to stress
I3X05_07655	COG2992	FlgJ-related protein
I3X05_07665	COG3842	ATPase activity
I3X05_07675	COG1177	transmembrane transport
I3X05_07680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3X05_07685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3X05_07695	COG0004	ammonium transporteR
I3X05_07700	COG0488	(ABC) transporter
I3X05_07705	COG0746	molybdenum cofactor guanylyltransferase activity
I3X05_07710	COG1763	Mo-molybdopterin cofactor biosynthetic process
I3X05_07720	COG1940	carbohydrate kinase activity
I3X05_07725	COG3148	PFAM DTW domain containing protein
I3X05_07735	COG0840	transmembrane signaling receptor activity
I3X05_07740	COG0791	NLP P60 protein
I3X05_07750	COG3706	GGDEF domain
I3X05_07770	COG0307	riboflavin synthase, alpha
I3X05_07775	COG0534	Mate efflux family protein
I3X05_07805	COG0584	glycerophosphoryl diester phosphodiesterase
I3X05_07810	COG1609	Transcriptional regulator
I3X05_07815	COG2723	6-phospho-beta-galactosidase activity
I3X05_07825	COG5433	transposase activity
I3X05_07835	COG3335	DDE superfamily endonuclease
I3X05_07840	COG2433	Pfam Transposase IS66
I3X05_07865	COG5433	transposase activity
I3X05_07930	COG3093	addiction module antidote protein HigA
I3X05_07935	COG3549	Plasmid maintenance system killer
I3X05_08030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I3X05_08070	COG5433	transposase activity
I3X05_08095	COG3344	reverse transcriptase
I3X05_08105	COG5433	transposase activity
I3X05_08130	COG2433	Pfam Transposase IS66
I3X05_08140	COG3344	reverse transcriptase
I3X05_08180	COG2169	Transcriptional regulator
I3X05_08195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3X05_08200	COG1518	maintenance of DNA repeat elements
I3X05_08245	COG2026	Addiction module toxin, RelE StbE family
I3X05_08255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3X05_08330	COG5433	transposase activity
I3X05_08345	COG0454	-acetyltransferase
I3X05_08350	COG0454	-acetyltransferase
I3X05_08355	COG4115	mRNA cleavage
I3X05_08360	COG2161	toxin-antitoxin pair type II binding
I3X05_08375	COG5433	transposase activity
I3X05_08385	COG5433	transposase activity
I3X05_08390	COG5433	transposase activity
I3X05_08400	COG0456	acetyltransferase
I3X05_08545	COG5433	transposase activity
I3X05_08650	COG2433	Pfam Transposase IS66
I3X05_08800	COG0582	viral genome integration into host DNA
I3X05_08860	COG4628	conserved protein (DUF2132)
I3X05_08870	COG1028	Short-chain dehydrogenase reductase Sdr
I3X05_09015	COG0456	acetyltransferase
I3X05_09050	COG2433	Pfam Transposase IS66
I3X05_09215	COG5433	transposase activity
I3X05_09245	COG4115	mRNA cleavage
I3X05_09250	COG2161	toxin-antitoxin pair type II binding
I3X05_09395	COG0454	-acetyltransferase
I3X05_09510	COG3040	lipid binding
I3X05_09650	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I3X05_09660	COG5433	transposase activity
I3X05_09675	COG0346	lactoylglutathione lyase activity
I3X05_09755	COG2026	Addiction module toxin, RelE StbE family
I3X05_09770	COG5433	transposase activity
I3X05_09775	COG5433	transposase activity
I3X05_09885	COG5433	transposase activity
I3X05_09955	COG2944	sequence-specific DNA binding
I3X05_09960	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I3X05_10035	COG2026	Addiction module toxin, RelE StbE family
I3X05_10065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3X05_10080	COG0454	-acetyltransferase
I3X05_10130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3X05_10135	COG0363	glucosamine-6-phosphate deaminase activity
I3X05_10140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I3X05_10145	COG4565	transcriptional regulatory protein
I3X05_10150	COG3290	protein histidine kinase activity
I3X05_10165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3X05_10190	COG1115	amino acid carrier protein
I3X05_10200	COG1280	lysine exporter protein (LysE YggA)
I3X05_10205	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I3X05_10210	COG0384	phenazine biosynthesis protein PhzF
I3X05_10495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3X05_10520	COG0582	viral genome integration into host DNA
I3X05_10565	COG0010	Belongs to the arginase family
I3X05_10570	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3X05_10575	COG2986	histidine ammonia-lyase
I3X05_10590	COG0247	lactate metabolic process
I3X05_10590	COG0277	FAD linked oxidase domain protein
I3X05_10605	COG2885	chlorophyll binding
I3X05_10625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3X05_10640	COG1643	Atp-dependent helicase
I3X05_10645	COG0281	malic enzyme
I3X05_10650	COG2949	membrane
I3X05_10655	COG0471	metal ion transport
I3X05_10670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3X05_10680	COG0492	ferredoxin-NADP+ reductase activity
I3X05_10685	COG4988	ABC transporter
I3X05_10690	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3X05_10695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3X05_10705	COG5002	protein histidine kinase activity
I3X05_10705	COG5002	protein histidine kinase activity
I3X05_10720	COG3070	regulator of competence-specific genes
I3X05_10730	COG2431	L-lysine efflux transmembrane transporter activity
I3X05_10740	COG0076	glutamate decarboxylase activity
I3X05_10745	COG1737	Transcriptional regulator
I3X05_10750	COG1012	belongs to the aldehyde dehydrogenase family
I3X05_10750	COG1454	alcohol dehydrogenase
I3X05_10755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3X05_10760	COG3273	potassium ion transport
I3X05_10760	COG2985	domain, Protein
I3X05_10780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3X05_10800	COG0534	Mate efflux family protein
I3X05_10805	COG0702	epimerase
I3X05_10815	COG2814	Major facilitator Superfamily
I3X05_10825	COG1061	Type III restriction enzyme res subunit
I3X05_10840	COG5002	protein histidine kinase activity
I3X05_10845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3X05_10850	COG0737	Belongs to the 5'-nucleotidase family
I3X05_10860	COG3313	Fe-S protein
I3X05_10870	COG4134	Bacterial extracellular solute-binding protein
I3X05_10875	COG4135	transport system, permease component
I3X05_10880	COG4136	ATPase activity
I3X05_10885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3X05_10900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I3X05_10900	COG0116	Belongs to the methyltransferase superfamily
I3X05_10905	COG0564	pseudouridine synthase activity
I3X05_10910	COG0733	neurotransmitter:sodium symporter activity
I3X05_10920	COG0626	cystathionine gamma-synthase activity
I3X05_10925	COG2818	Glycosylase
I3X05_10940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3X05_10945	COG1983	PspC domain protein
I3X05_10955	COG1842	Phage shock protein A
I3X05_10960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I3X05_10985	COG4172	Belongs to the ABC transporter superfamily
I3X05_11000	COG1227	inorganic diphosphatase activity
I3X05_11015	COG3005	denitrification pathway
I3X05_11020	COG4459	periplasmic nitrate reductase
I3X05_11025	COG2116	formate transmembrane transporter activity
I3X05_11045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3X05_11050	COG1435	thymidine kinase activity
I3X05_11055	COG0215	cysteine-tRNA ligase activity
I3X05_11060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3X05_11065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3X05_11070	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I3X05_11075	COG3012	SEC-C Motif Domain Protein
I3X05_11080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3X05_11080	COG0140	phosphoribosyl-ATP diphosphatase activity
I3X05_11090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3X05_11095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3X05_11100	COG0131	Imidazoleglycerol-phosphate dehydratase
I3X05_11100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3X05_11105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3X05_11110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3X05_11115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3X05_11120	COG1757	Na H antiporter
I3X05_11130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3X05_11140	COG0482	sulfurtransferase activity
I3X05_11145	COG2915	High frequency lysogenization protein hflD homolog
I3X05_11150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3X05_11160	COG2268	Band 7 protein
I3X05_11170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3X05_11185	COG0300	oxidoreductase activity
I3X05_11195	COG0501	Belongs to the peptidase M48B family
I3X05_11205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3X05_11210	COG2226	methyltransferase
I3X05_11215	COG0156	8-amino-7-oxononanoate synthase activity
I3X05_11220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3X05_11235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3X05_11240	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I3X05_11250	COG1522	sequence-specific DNA binding
I3X05_11255	COG0686	Belongs to the AlaDH PNT family
I3X05_11265	COG0583	DNA-binding transcription factor activity
I3X05_11290	COG4608	Belongs to the ABC transporter superfamily
I3X05_11295	COG0444	Belongs to the ABC transporter superfamily
I3X05_11300	COG4166	transmembrane transport
I3X05_11305	COG4239	(ABC) transporter, permease
I3X05_11310	COG0601	transmembrane transport
I3X05_11320	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I3X05_11325	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I3X05_11335	COG0539	negative regulation of cytoplasmic translation
I3X05_11345	COG0616	signal peptide processing
I3X05_11350	COG1028	Short-chain dehydrogenase reductase Sdr
I3X05_11365	COG0587	DNA-directed DNA polymerase activity
I3X05_11370	COG0784	Response regulator, receiver
I3X05_11370	COG0835	chemotaxis
I3X05_11375	COG1940	carbohydrate kinase activity
I3X05_11380	COG0469	pyruvate kinase activity
I3X05_11385	COG4667	esterase of the alpha-beta hydrolase superfamily
I3X05_11400	COG0733	neurotransmitter:sodium symporter activity
I3X05_11410	COG2433	Pfam Transposase IS66
I3X05_11435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3X05_11435	COG1263	PTS System
I3X05_11440	COG0084	hydrolase, TatD family'
I3X05_11450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3X05_11455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3X05_11470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3X05_11485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3X05_11490	COG0416	fatty acid biosynthetic process
I3X05_11495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3X05_11500	COG1399	metal-binding, possibly nucleic acid-binding protein
I3X05_11505	COG0424	maF-like protein
I3X05_11515	COG1530	ribonuclease E activity
I3X05_11520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3X05_11525	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I3X05_11535	COG0572	uridine kinase
I3X05_11540	COG0489	protein tyrosine kinase activity
I3X05_11545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3X05_11545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3X05_11555	COG2186	Transcriptional regulator
I3X05_11560	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3X05_11570	COG0653	protein targeting
I3X05_11580	COG0366	Alpha amylase catalytic
I3X05_11590	COG4120	Belongs to the binding-protein-dependent transport system permease family
I3X05_11600	COG3092	negative regulation of chromosome organization
I3X05_11605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3X05_11610	COG0280	phosphate acetyltransferase
I3X05_11610	COG0857	belongs to the CobB CobQ family
I3X05_11620	COG0435	Glutathione S-transferase
I3X05_11630	COG0444	Belongs to the ABC transporter superfamily
I3X05_11635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3X05_11640	COG0601	transmembrane transport
I3X05_11650	COG0314	molybdopterin synthase activity
I3X05_11655	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I3X05_11660	COG0315	cyclic pyranopterin monophosphate synthase activity
I3X05_11665	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3X05_11670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3X05_11675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3X05_11680	COG2198	Histidine kinase
I3X05_11685	COG2204	response regulator
I3X05_11690	COG0556	nucleotide-excision repair
I3X05_11700	COG2814	Major facilitator Superfamily
I3X05_11705	COG1566	PFAM secretion protein HlyD family protein
I3X05_11715	COG4657	Part of a membrane complex involved in electron transport
I3X05_11720	COG2878	Part of a membrane complex involved in electron transport
I3X05_11725	COG4656	Part of a membrane complex involved in electron transport
I3X05_11730	COG4658	electron transport chain
I3X05_11735	COG4659	FMN binding
I3X05_11740	COG4660	Part of a membrane complex involved in electron transport
I3X05_11745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I3X05_11750	COG0346	lactoylglutathione lyase activity
I3X05_11760	COG2885	chlorophyll binding
I3X05_11765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3X05_11770	COG2056	Na+-H+ antiporter family
I3X05_11780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I3X05_11795	COG1028	Short-chain dehydrogenase reductase Sdr
I3X05_11800	COG1012	belongs to the aldehyde dehydrogenase family
I3X05_11800	COG1454	alcohol dehydrogenase
I3X05_11805	COG2095	MarC family integral membrane protein
I3X05_11825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3X05_11830	COG1757	Na H antiporter
I3X05_11840	COG3081	Nucleoid-associated protein
I3X05_11850	COG3083	sulfuric ester hydrolase activity
I3X05_11855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3X05_11875	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3X05_11880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3X05_11885	COG0778	Nitroreductase
I3X05_11890	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3X05_11890	COG1902	pentaerythritol trinitrate reductase activity
I3X05_11895	COG0616	signal peptide processing
I3X05_11900	COG0252	asparaginase activity
I3X05_11905	COG3139	Protein of unknown function (DUF1315)
I3X05_11920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3X05_11925	COG0676	glucose-6-phosphate 1-epimerase activity
I3X05_11940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3X05_11955	COG2873	o-acetylhomoserine
I3X05_11965	COG2239	Acts as a magnesium transporter
I3X05_11995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3X05_12000	COG2226	methyltransferase
I3X05_12015	COG1785	Belongs to the alkaline phosphatase family
I3X05_12020	COG2983	Belongs to the UPF0260 family
I3X05_12030	COG0745	RESPONSE REGULATOR receiver
I3X05_12035	COG2205	protein histidine kinase activity
I3X05_12080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3X05_12085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3X05_12095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3X05_12100	COG2832	Protein of unknown function (DUF454)
I3X05_12105	COG0745	RESPONSE REGULATOR receiver
I3X05_12110	COG0583	DNA-binding transcription factor activity
I3X05_12115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I3X05_12120	COG1286	toxin biosynthetic process
I3X05_12125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I3X05_12130	COG0285	dihydrofolate synthase activity
I3X05_12135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I3X05_12140	COG0101	tRNA pseudouridine synthase activity
I3X05_12150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3X05_12160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3X05_12180	COG3101	peptidyl-lysine hydroxylation
I3X05_12185	COG2860	membrane
I3X05_12190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3X05_12195	COG2890	protein-(glutamine-N5) methyltransferase activity
I3X05_12200	COG2840	Smr protein MutS2
I3X05_12205	COG2062	phosphohistidine phosphatase, SixA
I3X05_12210	COG1025	Belongs to the peptidase M16 family
I3X05_12215	COG1024	Enoyl-CoA hydratase
I3X05_12215	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3X05_12220	COG0183	Belongs to the thiolase family
I3X05_12225	COG1595	DNA-templated transcription, initiation
I3X05_12245	COG2853	Lipoprotein
I3X05_12260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3X05_12265	COG1138	Cytochrome C-type biogenesis protein
I3X05_12270	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I3X05_12275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3X05_12280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3X05_12285	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3X05_12290	COG4133	protoheme IX ABC transporter activity
I3X05_12300	COG0835	chemotaxis
I3X05_12310	COG1192	Involved in chromosome partitioning
I3X05_12315	COG2201	protein-glutamate methylesterase activity
I3X05_12320	COG2198	Histidine kinase
I3X05_12320	COG0784	Response regulator, receiver
I3X05_12320	COG0643	Histidine kinase
I3X05_12325	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I3X05_12360	COG1684	flagellar biosynthetic protein fliR
I3X05_12365	COG1987	bacterial-type flagellum assembly
I3X05_12415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3X05_12425	COG1677	Flagellar hook-basal body complex protein FliE
I3X05_12445	COG1516	flagellar protein fliS
I3X05_12455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I3X05_12460	COG1334	flagellar protein FlaG
I3X05_12465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3X05_12470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3X05_12475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3X05_12480	COG2837	iron assimilation
I3X05_12510	COG1393	Belongs to the ArsC family
I3X05_12515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3X05_12535	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I3X05_12540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3X05_12545	COG2716	regulation of RNA biosynthetic process
I3X05_12550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I3X05_12565	COG4783	chaperone-mediated protein folding
I3X05_12570	COG1393	Belongs to the ArsC family
I3X05_12590	COG2233	PERMEase
I3X05_12595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3X05_12600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3X05_12605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I3X05_12610	COG0121	glutamine amidotransferase
I3X05_12620	COG1960	acyl-CoA dehydrogenase activity
I3X05_12635	COG0328	RNA-DNA hybrid ribonuclease activity
I3X05_12640	COG2226	methyltransferase
I3X05_12645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3X05_12650	COG1388	LysM domain
I3X05_12650	COG0741	lytic transglycosylase activity
I3X05_12660	COG3021	interspecies interaction between organisms
I3X05_12665	COG0347	Belongs to the P(II) protein family
I3X05_12680	COG0825	malonyl-CoA metabolic process
I3X05_12685	COG0587	DNA-directed DNA polymerase activity
I3X05_12695	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3X05_12700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3X05_12705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I3X05_12710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3X05_12715	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I3X05_12725	COG0750	zinc metalloprotease
I3X05_12735	COG0575	Belongs to the CDS family
I3X05_12740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3X05_12745	COG0233	cytoplasmic translational termination
I3X05_12755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3X05_12760	COG0052	Belongs to the universal ribosomal protein uS2 family
I3X05_12765	COG0024	Methionine aminopeptidase
I3X05_12770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3X05_12785	COG3098	single-species biofilm formation
I3X05_12815	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3X05_12820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3X05_12825	COG0254	rRNA binding
I3X05_12830	COG1720	tRNA m6t6A37 methyltransferase activity
I3X05_12860	COG3469	chitinase activity
I3X05_12875	COG5433	transposase activity
I3X05_12885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I3X05_12890	COG5433	transposase activity
I3X05_12950	COG0753	catalase activity
I3X05_12970	COG0583	DNA-binding transcription factor activity
I3X05_13065	COG2885	chlorophyll binding
I3X05_13135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3X05_13140	COG0235	Class ii aldolase
I3X05_13145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3X05_13200	COG0733	neurotransmitter:sodium symporter activity
I3X05_13210	COG0514	ATP-dependent DNA helicase (RecQ)
I3X05_13215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3X05_13230	COG1477	protein flavinylation
I3X05_13235	COG2871	sodium ion transport
I3X05_13240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I3X05_13255	COG1805	sodium ion transport
I3X05_13260	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I3X05_13265	COG0271	Belongs to the BolA IbaG family
I3X05_13270	COG2813	Specifically methylates the guanine in position
I3X05_13280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3X05_13295	COG1595	DNA-templated transcription, initiation
I3X05_13310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3X05_13320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3X05_13325	COG2166	iron-sulfur cluster assembly
I3X05_13330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I3X05_13335	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I3X05_13355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3X05_13360	COG1074	ATP-dependent DNA helicase activity
I3X05_13365	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I3X05_13370	COG3083	sulfuric ester hydrolase activity
I3X05_13385	COG3141	response to X-ray
I3X05_13390	COG2171	N-acyltransferase activity
I3X05_13395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3X05_13400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3X05_13405	COG1349	DNA-binding transcription factor activity
I3X05_13410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3X05_13420	COG0456	acetyltransferase
I3X05_13445	COG0840	transmembrane signaling receptor activity
I3X05_13450	COG0583	DNA-binding transcription factor activity
I3X05_13455	COG2059	Chromate
I3X05_13470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3X05_13475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3X05_13485	COG0560	Phosphoserine phosphatase
I3X05_13495	COG0813	purine-nucleoside phosphorylase activity
I3X05_13500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I3X05_13505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I3X05_13510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I3X05_13515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3X05_13520	COG0084	hydrolase, TatD family'
I3X05_13550	COG3153	acetyltransferase
I3X05_13555	COG3154	lipid carrier protein
I3X05_13565	COG0826	peptidase U32
I3X05_13570	COG0826	peptidase U32
I3X05_13575	COG0534	Mate efflux family protein
I3X05_13590	COG1185	polyribonucleotide nucleotidyltransferase activity
I3X05_13595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3X05_13600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3X05_13605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3X05_13610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3X05_13615	COG0195	Participates in both transcription termination and antitermination
I3X05_13620	COG0779	Required for maturation of 30S ribosomal subunits
I3X05_13635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3X05_13640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3X05_13645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3X05_13650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3X05_13655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I3X05_13660	COG1534	Rna-binding protein
I3X05_13665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3X05_13675	COG2027	D-alanyl-D-alanine carboxypeptidase
I3X05_13680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3X05_13685	COG0739	heme binding
I3X05_13705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3X05_13710	COG0628	permease
I3X05_13720	COG0784	Response regulator, receiver
I3X05_13720	COG2205	protein histidine kinase activity
I3X05_13725	COG0747	negative chemotaxis
I3X05_13735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3X05_13740	COG0444	Belongs to the ABC transporter superfamily
I3X05_13745	COG4608	Belongs to the ABC transporter superfamily
I3X05_13755	COG2971	BadF BadG BcrA BcrD
I3X05_13770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3X05_13775	COG3842	ATPase activity
I3X05_13785	COG1840	ABC-type Fe3 transport system, periplasmic component
I3X05_13790	COG0004	ammonium transporteR
I3X05_13795	COG0347	Belongs to the P(II) protein family
I3X05_13800	COG4771	TonB-dependent receptor
I3X05_13820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3X05_13825	COG1121	(ABC) transporter
I3X05_13860	COG3112	Uncharacterised protein family (UPF0231)
I3X05_13865	COG1929	Belongs to the glycerate kinase type-1 family
I3X05_13870	COG1049	propionate catabolic process, 2-methylcitrate cycle
I3X05_13875	COG1752	Esterase of the alpha-beta hydrolase superfamily
I3X05_13880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3X05_13885	COG1643	Atp-dependent helicase
I3X05_13895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3X05_13900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3X05_13910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I3X05_13915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3X05_13925	COG0842	Transport permease protein
I3X05_13930	COG1131	(ABC) transporter
I3X05_13935	COG0659	secondary active sulfate transmembrane transporter activity
I3X05_13940	COG0288	reversible hydration of carbon dioxide
I3X05_13955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3X05_13960	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3X05_13965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3X05_13990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3X05_13995	COG1459	type II secretion system
I3X05_14005	COG0237	dephospho-CoA kinase activity
I3X05_14015	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I3X05_14020	COG0335	large ribosomal subunit rRNA binding
I3X05_14025	COG0336	Belongs to the RNA methyltransferase TrmD family
I3X05_14030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3X05_14035	COG0228	four-way junction DNA binding
I3X05_14040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I3X05_14045	COG4137	Cytochrome C assembly protein
I3X05_14050	COG4536	flavin adenine dinucleotide binding
I3X05_14055	COG1854	S-ribosylhomocysteine lyase activity
I3X05_14070	COG0612	Peptidase, M16
I3X05_14075	COG1238	metal cluster binding
I3X05_14085	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I3X05_14090	COG5016	pyruvate
I3X05_14090	COG0511	ligase activity, forming carbon-carbon bonds
I3X05_14095	COG3630	sodium ion export across plasma membrane
I3X05_14145	COG0527	aspartate kinase activity
I3X05_14150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3X05_14160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I3X05_14165	COG1546	Belongs to the CinA family
I3X05_14170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I3X05_14175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3X05_14185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3X05_14205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3X05_14210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I3X05_14215	COG0148	phosphopyruvate hydratase activity
I3X05_14220	COG0504	CTP synthase activity
I3X05_14225	COG3956	TIGRFAM MazG family protein
I3X05_14230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3X05_14250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I3X05_14260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3X05_14270	COG0681	Belongs to the peptidase S26 family
I3X05_14275	COG0481	GTPase activity
I3X05_14280	COG3086	response to oxidative stress
I3X05_14295	COG1595	DNA-templated transcription, initiation
I3X05_14300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3X05_14315	COG0354	folic acid binding
I3X05_14330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3X05_14335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3X05_14340	COG3079	Belongs to the UPF0149 family
I3X05_14345	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I3X05_14355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3X05_14365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3X05_14385	COG0668	transmembrane transport
I3X05_14390	COG0191	fructose-bisphosphate aldolase activity
I3X05_14395	COG0126	phosphoglycerate kinase activity
I3X05_14400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3X05_14405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3X05_14410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3X05_14420	COG2356	endonuclease I
I3X05_14430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3X05_14440	COG1678	Uncharacterized ACR, COG1678
I3X05_14445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3X05_14460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I3X05_14465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3X05_14470	COG0762	integral membrane protein
I3X05_14485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3X05_14490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3X05_14500	COG2066	Belongs to the glutaminase family
I3X05_14505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3X05_14515	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I3X05_14520	COG0741	lytic transglycosylase activity
I3X05_14575	COG1012	belongs to the aldehyde dehydrogenase family
I3X05_14620	COG1278	Cold shock
I3X05_14625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3X05_14715	COG2916	Histone family protein nucleoid-structuring protein H-NS
I3X05_14790	COG0795	lipopolysaccharide-transporting ATPase activity
I3X05_14795	COG0795	lipopolysaccharide-transporting ATPase activity
I3X05_14800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3X05_14805	COG2927	DNA polymerase III (CHI subunit)
I3X05_14810	COG0525	valine-tRNA ligase activity
I3X05_14820	COG0456	acetyltransferase
I3X05_14850	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I3X05_14855	COG0251	oxidation-reduction process
I3X05_14860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3X05_14870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3X05_14875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3X05_14880	COG0312	modulator of DNA gyrase
I3X05_14885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3X05_14890	COG3164	Protein of unknown function
I3X05_14900	COG0424	maF-like protein
I3X05_14905	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I3X05_14910	COG1792	Involved in formation and maintenance of cell shape
I3X05_14915	COG1077	Cell shape determining protein MreB Mrl
I3X05_14945	COG2165	general secretion pathway protein
I3X05_14960	COG1459	type II secretion system
I3X05_14965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3X05_14975	COG3409	Peptidoglycan-binding domain 1 protein
I3X05_14975	COG3267	Type II secretory pathway component ExeA
I3X05_15000	COG2200	EAL domain
I3X05_15000	COG2199	diguanylate cyclase activity
I3X05_15005	COG0629	single-stranded DNA binding
I3X05_15025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3X05_15035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I3X05_15040	COG0527	aspartate kinase activity
I3X05_15045	COG0646	methionine synthase
I3X05_15045	COG1410	methionine synthase
I3X05_15055	COG0204	Acyl-transferase
I3X05_15060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3X05_15065	COG5007	Belongs to the BolA IbaG family
I3X05_15075	COG2854	intermembrane phospholipid transfer
I3X05_15080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3X05_15085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3X05_15090	COG1127	ABC transporter
I3X05_15100	COG0517	IMP dehydrogenase activity
I3X05_15100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I3X05_15105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I3X05_15120	COG1137	ATPase activity
I3X05_15130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3X05_15135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3X05_15140	COG1660	Displays ATPase and GTPase activities
I3X05_15145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3X05_15150	COG2239	Acts as a magnesium transporter
I3X05_15155	COG0312	modulator of DNA gyrase
I3X05_15160	COG3028	Belongs to the UPF0307 family
I3X05_15165	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I3X05_15170	COG1178	ABC-type Fe3 transport system permease component
I3X05_15175	COG4143	(ABC) transporter
I3X05_15180	COG0163	prenyltransferase activity
I3X05_15185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3X05_15190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I3X05_15195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3X05_15200	COG2105	PFAM AIG2 family protein
I3X05_15205	COG2911	Protein conserved in bacteria
I3X05_15210	COG0729	surface antigen
I3X05_15225	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I3X05_15240	COG1136	(ABC) transporter
I3X05_15240	COG0577	efflux transmembrane transporter activity
I3X05_15260	COG0529	Catalyzes the synthesis of activated sulfate
I3X05_15265	COG3273	potassium ion transport
I3X05_15265	COG0471	metal ion transport
I3X05_15270	COG2895	sulfate adenylyltransferase (ATP) activity
I3X05_15280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3X05_15280	COG1648	precorrin-2 dehydrogenase activity
I3X05_15285	COG0737	Belongs to the 5'-nucleotidase family
I3X05_15295	COG2153	protein acetylation
I3X05_15300	COG0697	spore germination
I3X05_15310	COG0545	Peptidyl-prolyl cis-trans isomerase
I3X05_15315	COG0203	ribosomal protein L17
I3X05_15320	COG0202	RNA polymerase activity
I3X05_15330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3X05_15335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3X05_15340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3X05_15345	COG0201	protein transport
I3X05_15350	COG0200	Binds to the 23S rRNA
I3X05_15355	COG1841	ribosomal large subunit assembly
I3X05_15360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3X05_15365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3X05_15370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3X05_15375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3X05_15380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3X05_15385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3X05_15390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3X05_15395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3X05_15400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3X05_15410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3X05_15415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3X05_15425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3X05_15430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3X05_15440	COG0088	Forms part of the polypeptide exit tunnel
I3X05_15445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3X05_15460	COG2906	2 iron, 2 sulfur cluster binding
I3X05_15470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3X05_15475	COG0049	tRNA binding
I3X05_15480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3X05_15490	COG2923	Belongs to the DsrF TusC family
I3X05_15495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I3X05_15500	COG2964	Protein conserved in bacteria
I3X05_15505	COG0545	Peptidyl-prolyl cis-trans isomerase
I3X05_15515	COG2900	Belongs to the SlyX family
I3X05_15525	COG1047	Peptidyl-prolyl cis-trans
I3X05_15540	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3X05_15545	COG0488	(ABC) transporter
I3X05_15555	COG0429	hydrolase of the alpha beta-hydrolase fold
I3X05_15560	COG3089	Belongs to the UPF0270 family
I3X05_15565	COG3954	Phosphoribulokinase
I3X05_15570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3X05_15575	COG3344	reverse transcriptase
I3X05_15585	COG1012	belongs to the aldehyde dehydrogenase family
I3X05_15595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3X05_15605	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3X05_15610	COG2356	endonuclease I
I3X05_15630	COG3344	reverse transcriptase
I3X05_15635	COG0180	Tryptophanyl-tRNA synthetase
I3X05_15645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3X05_15650	COG0557	exoribonuclease II activity
I3X05_15655	COG1959	2 iron, 2 sulfur cluster binding
I3X05_15660	COG1017	nitric oxide dioxygenase activity
I3X05_15660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3X05_15665	COG3344	reverse transcriptase
I3X05_15670	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3X05_15675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3X05_15680	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I3X05_15685	COG0330	HflC and HflK could
I3X05_15690	COG0330	HflC and HflK could
I3X05_15695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3X05_15710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I3X05_15715	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3X05_15720	COG0802	atpase or kinase
I3X05_15725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I3X05_15775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3X05_15780	COG1162	GTPase activity
I3X05_15785	COG0688	phosphatidylethanolamine metabolic process
I3X05_15790	COG0471	metal ion transport
I3X05_15805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3X05_15810	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I3X05_15815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3X05_15820	COG1045	serine acetyltransferase
I3X05_15825	COG4942	peptidase
I3X05_15845	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I3X05_15850	COG1053	succinate dehydrogenase
I3X05_15855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3X05_15860	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I3X05_15870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3X05_15875	COG1509	lysine 2,3-aminomutase activity
I3X05_15890	COG0459	protein refolding
I3X05_15895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3X05_15900	COG0534	Mate efflux family protein
I3X05_15905	COG0205	6-phosphofructokinase activity
I3X05_15915	COG3678	ATP-independent chaperone mediated protein folding
I3X05_15920	COG0745	RESPONSE REGULATOR receiver
I3X05_15925	COG2205	protein histidine kinase activity
I3X05_15930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3X05_15940	COG1027	Aspartate ammonia-lyase
I3X05_15945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3X05_15950	COG4232	protein-disulfide reductase activity
I3X05_15960	COG3263	regulation of cellular component size
I3X05_15970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3X05_15975	COG2205	protein histidine kinase activity
I3X05_15975	COG2198	Histidine kinase
I3X05_15975	COG0784	Response regulator, receiver
I3X05_15980	COG2814	Major facilitator Superfamily
I3X05_15995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3X05_16000	COG1902	pentaerythritol trinitrate reductase activity
I3X05_16010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3X05_16015	COG0511	ligase activity, forming carbon-carbon bonds
I3X05_16020	COG0439	Biotin carboxylase
I3X05_16035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I3X05_16065	COG0840	transmembrane signaling receptor activity
I3X05_16070	COG0789	Transcriptional regulator
I3X05_16080	COG0138	bifunctional purine biosynthesis protein purh
I3X05_16100	COG1253	flavin adenine dinucleotide binding
I3X05_16105	COG3068	Protein conserved in bacteria
I3X05_16110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3X05_16115	COG1573	uracil-dna glycosylase
I3X05_16120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3X05_16135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3X05_16140	COG0085	RNA polymerase activity
I3X05_16145	COG0222	ribosome binding
I3X05_16150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3X05_16155	COG0081	regulation of translation
I3X05_16170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3X05_16210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3X05_16220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3X05_16230	COG3335	DDE superfamily endonuclease
I3X05_16245	COG3335	DDE superfamily endonuclease
I3X05_16325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3X05_16335	COG4206	TonB-dependent receptor
I3X05_16340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3X05_16370	COG1518	maintenance of DNA repeat elements
I3X05_16380	COG1464	Belongs to the NlpA lipoprotein family
I3X05_16395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3X05_16405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3X05_16410	COG2937	Belongs to the GPAT DAPAT family
I3X05_16415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3X05_16425	COG1580	Controls the rotational direction of flagella during chemotaxis
I3X05_16435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3X05_16445	COG2177	Part of the ABC transporter FtsEX involved in
I3X05_16450	COG2884	Cell division ATP-binding protein ftsE
I3X05_16455	COG0552	protein localization to endoplasmic reticulum
I3X05_16460	COG0742	ribosomal rna small subunit methyltransferase
I3X05_16470	COG2095	MarC family integral membrane protein
I3X05_16490	COG3274	enterobacterial common antigen metabolic process
I3X05_16495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I3X05_16500	COG1280	lysine exporter protein (LysE YggA)
I3X05_16505	COG2267	carboxylic ester hydrolase activity
I3X05_16510	COG0561	phosphatase activity
I3X05_16525	COG3148	PFAM DTW domain containing protein
I3X05_16530	COG3287	FIST C domain
I3X05_16530	COG2200	EAL domain
I3X05_16530	COG2199	diguanylate cyclase activity
I3X05_16535	COG1011	Hydrolase
I3X05_16540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I3X05_16550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3X05_16555	COG0019	diaminopimelate decarboxylase activity
I3X05_16565	COG1965	Belongs to the frataxin family
I3X05_16570	COG3072	Adenylate cyclase
I3X05_16575	COG0181	hydroxymethylbilane synthase activity
I3X05_16585	COG2959	enzyme of heme biosynthesis
I3X05_16590	COG3071	HemY protein
I3X05_16630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3X05_16645	COG3118	belongs to the thioredoxin family
I3X05_16655	COG0248	Ppx GppA phosphatase
I3X05_16660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I3X05_16670	COG0514	ATP-dependent DNA helicase (RecQ)
I3X05_16675	COG2962	Rard protein
I3X05_16685	COG1280	lysine exporter protein (LysE YggA)
I3X05_16690	COG0210	DNA helicase
I3X05_16700	COG3220	belongs to the UPF0276 family
I3X05_16730	COG0006	proline dipeptidase activity
I3X05_16730	COG0006	proline dipeptidase activity
I3X05_16740	COG2022	thiamine diphosphate biosynthetic process
I3X05_16750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3X05_16760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3X05_16765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3X05_16810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3X05_16820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3X05_16825	COG0408	coproporphyrinogen oxidase activity
I3X05_16830	COG0009	L-threonylcarbamoyladenylate synthase
I3X05_16835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3X05_16840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3X05_16845	COG0551	DNA topoisomerase type I activity
I3X05_16850	COG2922	Belongs to the Smg family
I3X05_16855	COG0758	DNA mediated transformation
I3X05_16865	COG0242	peptide deformylase activity
I3X05_16870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3X05_16875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3X05_16875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I3X05_16880	COG0569	domain protein
I3X05_16885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3X05_16895	COG1272	protein, Hemolysin III
I3X05_16900	COG4326	sporulation control protein
I3X05_16905	COG3084	Protein conserved in bacteria
I3X05_16915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3X05_16920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3X05_16925	COG0204	Acyl-transferase
I3X05_16980	COG3978	acetolactate synthase activity
I3X05_16985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3X05_17000	COG0583	DNA-binding transcription factor activity
I3X05_17005	COG2814	Major facilitator Superfamily
I3X05_17015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3X05_17020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3X05_17025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3X05_17030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3X05_17035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3X05_17040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3X05_17050	COG0356	it plays a direct role in the translocation of protons across the membrane
I3X05_17055	COG3312	ion transport
I3X05_17060	COG1475	DNA binding
I3X05_17065	COG1192	Involved in chromosome partitioning
I3X05_17070	COG0357	Ribosomal RNA small subunit methyltransferase G
I3X05_17075	COG0445	tRNA wobble uridine modification
I3X05_17080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3X05_17090	COG0706	membrane insertase activity
I3X05_17100	COG0594	ribonuclease P activity
I3X05_17105	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3X05_17110	COG1126	abc transporter atp-binding protein
I3X05_17170	COG0811	peptide transport
I3X05_17175	COG0811	peptide transport
I3X05_17180	COG0848	biopolymer transport protein
I3X05_17195	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3X05_17200	COG0840	transmembrane signaling receptor activity
I3X05_17215	COG0534	Mate efflux family protein
I3X05_17230	COG3118	belongs to the thioredoxin family
I3X05_17235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3X05_17280	COG5433	transposase activity
I3X05_17290	COG1328	CTP reductase activity
I3X05_17295	COG0602	queuosine metabolic process
I3X05_17305	COG4067	protein conserved in archaea
I3X05_17305	COG0189	ligase activity
I3X05_17325	COG0725	ABC transporter, periplasmic molybdate-binding protein
I3X05_17330	COG4149	molybdate abc transporter
I3X05_17335	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I3X05_17365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I3X05_17370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I3X05_17380	COG0745	RESPONSE REGULATOR receiver
I3X05_17395	COG3140	Belongs to the UPF0181 family
I3X05_17420	COG5433	transposase activity
I3X05_17515	COG0023	Translation Initiation Factor
I3X05_17540	COG1042	CoA-binding domain protein
I3X05_17540	COG0045	succinate-CoA ligase (ADP-forming) activity
I3X05_17540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3X05_17545	COG0583	DNA-binding transcription factor activity
I3X05_17550	COG4771	TonB-dependent receptor
I3X05_17550	COG1629	transport
I3X05_17565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3X05_17575	COG1984	allophanate hydrolase subunit 2
I3X05_17585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I3X05_17590	COG4181	ATPase activity
I3X05_17600	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3X05_17605	COG5001	Diguanylate cyclase
I3X05_17605	COG1716	ATPase activity
I3X05_17615	COG0484	heat shock protein binding
I3X05_17630	COG1324	tolerance protein
I3X05_17640	COG0366	Alpha amylase catalytic
I3X05_17645	COG4533	DNA binding
I3X05_17655	COG2050	protein possibly involved in aromatic compounds catabolism
I3X05_17665	COG0750	zinc metalloprotease
I3X05_17670	COG2067	long-chain fatty acid transport protein
I3X05_17675	COG2267	carboxylic ester hydrolase activity
I3X05_17695	COG0861	Integral membrane protein TerC family
I3X05_17700	COG0737	Belongs to the 5'-nucleotidase family
I3X05_17705	COG3593	DNA synthesis involved in DNA repair
I3X05_17715	COG0583	DNA-binding transcription factor activity
I3X05_17720	COG2116	formate transmembrane transporter activity
I3X05_17725	COG2353	YceI-like domain
I3X05_17730	COG3038	cytochrome b561
I3X05_17745	COG0513	Belongs to the DEAD box helicase family
I3X05_17750	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I3X05_17755	COG0840	transmembrane signaling receptor activity
I3X05_17760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3X05_17775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3X05_17780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I3X05_17785	COG0488	(ABC) transporter
I3X05_17800	COG2207	Transcriptional regulator
I3X05_17805	COG1979	alcohol dehydrogenase
I3X05_17815	COG4191	Histidine kinase
I3X05_17825	COG2271	Major facilitator Superfamily
I3X05_17830	COG0469	pyruvate kinase activity
I3X05_17835	COG0454	-acetyltransferase
I3X05_17840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3X05_17845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3X05_17855	COG5002	protein histidine kinase activity
I3X05_17900	COG1609	Transcriptional regulator
I3X05_17905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3X05_17905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3X05_17910	COG1105	Belongs to the carbohydrate kinase PfkB family
I3X05_17915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3X05_17915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3X05_17915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I3X05_17930	COG2223	nitrite transmembrane transporter activity
I3X05_17980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3X05_17990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3X05_17995	COG0509	glycine decarboxylation via glycine cleavage system
I3X05_18000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3X05_18000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3X05_18015	COG0840	transmembrane signaling receptor activity
I3X05_18025	COG2017	converts alpha-aldose to the beta-anomer
I3X05_18035	COG1085	galactose-1-phosphate uridylyltransferase
I3X05_18040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3X05_18045	COG2211	Major facilitator Superfamily
I3X05_18055	COG3250	beta-galactosidase activity
I3X05_18065	COG1129	ABC transporter
I3X05_18075	COG0419	ATPase involved in DNA repair
I3X05_18120	COG0835	chemotaxis
I3X05_18120	COG0784	Response regulator, receiver
I3X05_18125	COG1609	Transcriptional regulator
I3X05_18130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3X05_18135	COG1879	ABC-type sugar transport system periplasmic component
I3X05_18140	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3X05_18145	COG1129	ABC transporter
I3X05_18150	COG1869	D-ribose catabolic process
I3X05_18165	COG2315	Protein conserved in bacteria
I3X05_18185	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I3X05_18195	COG1126	abc transporter atp-binding protein
I3X05_18205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3X05_18210	COG4597	amino acid ABC transporter
I3X05_18220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3X05_18230	COG0456	acetyltransferase
I3X05_18230	COG1214	PFAM Peptidase M22, glycoprotease
I3X05_18235	COG0840	transmembrane signaling receptor activity
I3X05_18255	COG2271	Major facilitator Superfamily
I3X05_18260	COG0584	glycerophosphoryl diester phosphodiesterase
I3X05_18265	COG0312	modulator of DNA gyrase
I3X05_18270	COG0312	modulator of DNA gyrase
I3X05_18275	COG5002	protein histidine kinase activity
I3X05_18275	COG5001	Diguanylate cyclase
I3X05_18280	COG0814	amino acid
I3X05_18325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3X05_18410	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3X05_18415	COG3186	Phenylalanine-4-hydroxylase
I3X05_18420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3X05_18425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3X05_18450	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I3X05_18455	COG1454	alcohol dehydrogenase
I3X05_18460	COG2133	pyrroloquinoline quinone binding
I3X05_18480	COG0247	lactate metabolic process
I3X05_18485	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I3X05_18490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3X05_18510	COG1716	ATPase activity
I3X05_18510	COG5001	Diguanylate cyclase
I3X05_18515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I3X05_18525	COG4175	Glycine betaine
I3X05_18545	COG1012	belongs to the aldehyde dehydrogenase family
I3X05_18550	COG1309	transcriptional regulator
I3X05_18560	COG4176	ABC-type proline glycine betaine transport system permease component
I3X05_18565	COG2113	Glycine betaine
I3X05_18570	COG5433	transposase activity
I3X05_18585	COG1278	Cold shock
I3X05_18590	COG0557	exoribonuclease II activity
I3X05_18635	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3X05_18640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3X05_18645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3X05_18655	COG0356	it plays a direct role in the translocation of protons across the membrane
I3X05_18675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3X05_18680	COG3135	benzoate transporter
I3X05_18685	COG1396	sequence-specific DNA binding
I3X05_18700	COG5433	transposase activity
I3X05_18705	COG5433	transposase activity
I3X05_18750	COG0745	RESPONSE REGULATOR receiver
I3X05_18755	COG2205	protein histidine kinase activity
I3X05_18765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3X05_18780	COG3328	transposase activity
I3X05_18835	COG1196	nuclear chromosome segregation
I3X05_18875	COG2188	Transcriptional regulator
I3X05_18880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3X05_18880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3X05_18880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3X05_18885	COG0383	alpha-mannosidase activity
I3X05_18890	COG1929	Belongs to the glycerate kinase type-1 family
I3X05_18930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3X05_18940	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I3X05_18955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I3X05_18960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3X05_18970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3X05_18980	COG1280	lysine exporter protein (LysE YggA)
I3X05_19005	COG1846	Transcriptional regulator
I3X05_19010	COG1764	response to oxidative stress
I3X05_19020	COG0697	spore germination
I3X05_19035	COG2814	Major facilitator Superfamily
I3X05_19040	COG0583	DNA-binding transcription factor activity
I3X05_19045	COG5001	Diguanylate cyclase
I3X05_19050	COG0739	heme binding
I3X05_19065	COG3314	Sporulation integral membrane protein YlbJ
I3X05_19080	COG0366	Alpha amylase catalytic
I3X05_19085	COG0625	glutathione transferase activity
I3X05_19090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3X05_19095	COG0835	chemotaxis
I3X05_19095	COG0784	Response regulator, receiver
I3X05_19105	COG0748	coenzyme F420 binding
I3X05_19110	COG3721	Heme iron utilization protein
I3X05_19120	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I3X05_19125	COG0811	peptide transport
I3X05_19130	COG0848	biopolymer transport protein
I3X05_19135	COG4558	Periplasmic binding protein
I3X05_19140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3X05_19145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3X05_19180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3X05_19185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3X05_19190	COG3217	Mosc domain protein beta barrel domain protein
I3X05_19190	COG0633	Ferredoxin
I3X05_19190	COG0633	Ferredoxin
I3X05_19190	COG3217	Mosc domain protein beta barrel domain protein
I3X05_19195	COG0418	dihydroorotase activity
I3X05_19200	COG3706	GGDEF domain
I3X05_19205	COG2354	Protein conserved in bacteria
I3X05_19235	COG3833	ABC-type maltose transport systems, permease component
I3X05_19240	COG1175	transmembrane transport
I3X05_19250	COG3842	ATPase activity
I3X05_19265	COG0714	Associated with various cellular activities
I3X05_19285	COG2304	oxidoreductase activity
I3X05_19295	COG3706	GGDEF domain
I3X05_19300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3X05_19305	COG0581	inorganic phosphate transmembrane transporter activity
I3X05_19310	COG0573	inorganic phosphate transmembrane transporter activity
I3X05_19345	COG1770	oligopeptidase
I3X05_19350	COG0513	Belongs to the DEAD box helicase family
I3X05_19360	COG1388	LysM domain
I3X05_19360	COG1376	ErfK ybiS ycfS ynhG family protein
I3X05_19365	COG0415	Belongs to the DNA photolyase family
I3X05_19370	COG0789	Transcriptional regulator
I3X05_19375	COG3272	Protein of unknown function (DUF1722)
I3X05_19380	COG0813	purine-nucleoside phosphorylase activity
I3X05_19400	COG4720	Psort location CytoplasmicMembrane, score
I3X05_19415	COG0243	molybdopterin cofactor binding
I3X05_19420	COG0583	DNA-binding transcription factor activity
I3X05_19425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3X05_19440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3X05_19460	COG1067	ATP-dependent peptidase activity
I3X05_19470	COG4172	Belongs to the ABC transporter superfamily
I3X05_19475	COG1505	serine-type exopeptidase activity
I3X05_19480	COG0583	DNA-binding transcription factor activity
I3X05_19485	COG1620	l-lactate permease
I3X05_19490	COG1304	FMN binding
I3X05_19505	COG2814	Major facilitator Superfamily
I3X05_19540	COG3015	lipoprotein NlpE involved in copper resistance
I3X05_19545	COG1126	abc transporter atp-binding protein
I3X05_19550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3X05_19555	COG4215	(ABC) transporter
I3X05_19560	COG4160	amino acid transport
I3X05_19580	COG0840	transmembrane signaling receptor activity
I3X05_19585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3X05_19605	COG0189	ligase activity
I3X05_19610	COG0189	ligase activity
I3X05_19610	COG4067	protein conserved in archaea
I3X05_19640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3X05_19650	COG5002	protein histidine kinase activity
I3X05_19655	COG0745	RESPONSE REGULATOR receiver
I3X05_19670	COG0840	transmembrane signaling receptor activity
I3X05_19695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3X05_19695	COG1017	nitric oxide dioxygenase activity
I3X05_19700	COG0242	peptide deformylase activity
I3X05_19705	COG1253	flavin adenine dinucleotide binding
I3X05_19710	COG1686	Belongs to the peptidase S11 family
I3X05_19720	COG1629	transport
I3X05_19735	COG1760	l-serine dehydratase
I3X05_19740	COG3104	oligopeptide transport
I3X05_19755	COG2207	Transcriptional regulator
I3X05_19755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3X05_19760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3X05_19770	COG1011	Hydrolase
I3X05_19795	COG1765	OsmC-like protein
I3X05_19800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3X05_19800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3X05_19805	COG3706	GGDEF domain
I3X05_19840	COG2188	Transcriptional regulator
I3X05_19850	COG2201	protein-glutamate methylesterase activity
I3X05_19860	COG3852	Histidine kinase
I3X05_19865	COG2202	Pas domain
I3X05_19865	COG2199	diguanylate cyclase activity
I3X05_19865	COG2200	EAL domain
I3X05_19875	COG4191	Histidine kinase
I3X05_19885	COG5001	Diguanylate cyclase
I3X05_19885	COG3300	MHYT domain
I3X05_19915	COG3842	ATPase activity
I3X05_19925	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I3X05_19930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I3X05_19935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3X05_19940	COG2375	cellular response to nickel ion
I3X05_19950	COG0668	transmembrane transport
I3X05_19975	COG1881	PFAM PEBP family protein
I3X05_19990	COG3046	protein related to deoxyribodipyrimidine photolyase
I3X05_20005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3X05_20020	COG1342	Belongs to the UPF0251 family
I3X05_20045	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I3X05_20060	COG0583	DNA-binding transcription factor activity
I3X05_20100	COG1283	sodium-dependent phosphate transmembrane transporter activity
I3X05_20105	COG0625	glutathione transferase activity
I3X05_20115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3X05_20125	COG3047	cAMP biosynthetic process
I3X05_20130	COG0579	oxidoreductase
I3X05_20155	COG0583	DNA-binding transcription factor activity
I3X05_20160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I3X05_20165	COG1271	oxidase subunit
I3X05_20170	COG1294	oxidase, subunit
I3X05_20175	COG0625	glutathione transferase activity
I3X05_20180	COG0583	DNA-binding transcription factor activity
I3X05_20200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3X05_20200	COG1263	PTS System
I3X05_20210	COG1621	beta-fructofuranosidase activity
I3X05_20215	COG2203	Gaf domain
I3X05_20215	COG5001	Diguanylate cyclase
I3X05_20215	COG3706	GGDEF domain
I3X05_20215	COG4251	negative regulation of phosphorylation
I3X05_20220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3X05_20260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3X05_20265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3X05_20270	COG1640	4-alpha-glucanotransferase
I3X05_20275	COG0058	SHG alpha-glucan phosphorylase activity
I3X05_20280	COG2909	trisaccharide binding
I3X05_20300	COG3842	ATPase activity
I3X05_20310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3X05_20320	COG2182	Extracellular solute-binding protein
I3X05_20325	COG1175	transmembrane transport
I3X05_20330	COG3833	ABC-type maltose transport systems, permease component
I3X05_20360	COG4771	TonB-dependent receptor
I3X05_20365	COG2382	esterase
I3X05_20375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I3X05_20380	COG1162	GTPase activity
I3X05_20390	COG1999	signal sequence binding
I3X05_20415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3X05_20440	COG0259	pyridoxamine-phosphate oxidase activity
I3X05_20450	COG2204	response regulator
I3X05_20475	COG0215	cysteine-tRNA ligase activity
I3X05_20485	COG1444	tRNA N-acetyltransferase activity
I3X05_20505	COG3227	Zinc metalloprotease (Elastase)
I3X05_20535	COG0217	transcriptional regulatory protein
I3X05_20545	COG1136	(ABC) transporter
I3X05_20565	COG3275	phosphorelay sensor kinase activity
I3X05_20570	COG3279	Response regulator of the LytR AlgR family
I3X05_20580	COG0786	glutamate:sodium symporter activity
I3X05_20585	COG0786	glutamate:sodium symporter activity
I3X05_20595	COG0363	glucosamine-6-phosphate deaminase activity
I3X05_20610	COG0189	ligase activity
I3X05_20630	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I3X05_20640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3X05_20675	COG3123	guanosine phosphorylase activity
I3X05_20700	COG3220	belongs to the UPF0276 family
I3X05_20715	COG1741	Belongs to the pirin family
I3X05_20725	COG5001	Diguanylate cyclase
I3X05_20775	COG1132	(ABC) transporter
I3X05_20785	COG0513	Belongs to the DEAD box helicase family
I3X05_20800	COG1278	Cold shock
I3X05_20805	COG0840	transmembrane signaling receptor activity
I3X05_20855	COG0513	Belongs to the DEAD box helicase family
I3X05_20885	COG1022	Amp-dependent synthetase and ligase
I3X05_20910	COG0642	Histidine kinase
I3X05_20915	COG0564	pseudouridine synthase activity
I3X05_20925	COG3220	belongs to the UPF0276 family
I3X05_20955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3X05_20970	COG1741	Belongs to the pirin family
I3X05_20975	COG2259	Doxx family
I3X05_20980	COG0366	Alpha amylase catalytic
I3X05_20985	COG1349	DNA-binding transcription factor activity
I3X05_20990	COG0673	inositol 2-dehydrogenase activity
I3X05_20995	COG4702	Belongs to the UPF0303 family
I3X05_21000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3X05_21030	COG3284	Transcriptional regulator
I3X05_21035	COG1012	belongs to the aldehyde dehydrogenase family
I3X05_21055	COG0513	Belongs to the DEAD box helicase family
I3X05_21075	COG0842	Transport permease protein
I3X05_21080	COG1131	(ABC) transporter
I3X05_21095	COG1737	Transcriptional regulator
I3X05_21105	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3X05_21130	COG0251	oxidation-reduction process
I3X05_21135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3X05_21140	COG2084	Dehydrogenase
I3X05_21150	COG2201	protein-glutamate methylesterase activity
I3X05_21155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I3X05_21170	COG0840	transmembrane signaling receptor activity
I3X05_21175	COG0835	chemotaxis
I3X05_21180	COG2198	Histidine kinase
I3X05_21180	COG0643	Histidine kinase
I3X05_21190	COG0745	RESPONSE REGULATOR receiver
I3X05_21210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3X05_21220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3X05_21235	COG0039	L-malate dehydrogenase activity
I3X05_21245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3X05_21260	COG0393	Putative heavy-metal-binding
I3X05_21265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I3X05_21275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3X05_21295	COG2211	Major facilitator Superfamily
I3X05_21310	COG3240	lipase activity
I3X05_21315	COG0156	8-amino-7-oxononanoate synthase activity
I3X05_21360	COG5433	transposase activity
I3X05_21375	COG1278	Cold shock
I3X05_21395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3X05_21405	COG0753	catalase activity
I3X05_21420	COG0789	Transcriptional regulator
I3X05_21435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3X05_21440	COG0459	protein refolding
I3X05_21455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3X05_21460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3X05_21460	COG1263	PTS System
I3X05_21490	COG0783	Belongs to the Dps family
I3X05_21515	COG0640	Transcriptional regulator
I3X05_21520	COG0798	PFAM Bile acid sodium symporter
I3X05_21530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3X05_21540	COG0573	inorganic phosphate transmembrane transporter activity
I3X05_21555	COG0640	Transcriptional regulator
I3X05_21560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3X05_21600	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I3X05_21620	COG4977	sequence-specific DNA binding
I3X05_21620	COG1917	Cupin 2, conserved barrel domain protein
I3X05_21625	COG1335	isochorismatase
I3X05_21640	COG1301	dicarboxylic acid transport
I3X05_21670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3X05_21685	COG2356	endonuclease I
I3X05_21695	COG1368	sulfuric ester hydrolase activity
I3X05_21700	COG2194	sulfuric ester hydrolase activity
I3X05_21705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3X05_21710	COG2205	protein histidine kinase activity
I3X05_21715	COG0745	RESPONSE REGULATOR receiver
I3X05_21720	COG2910	NAD(P)H-binding
I3X05_21735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3X05_21745	COG4533	DNA binding
I3X05_21755	COG0561	phosphatase activity
I3X05_21770	COG0671	phosphoesterase, PA-phosphatase related
I3X05_21775	COG0351	phosphomethylpyrimidine kinase
I3X05_21845	COG3335	DDE superfamily endonuclease
I3X05_21865	COG2433	Pfam Transposase IS66
I3X05_21890	COG0668	transmembrane transport
I3X05_21905	COG2239	Acts as a magnesium transporter
I3X05_21910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3X05_21915	COG0121	glutamine amidotransferase
I3X05_21920	COG0531	amino acid
I3X05_21945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3X05_21950	COG0583	DNA-binding transcription factor activity
I3X05_21970	COG0534	Mate efflux family protein
I3X05_21975	COG2926	Belongs to the UPF0265 family
I3X05_21990	COG2827	Endonuclease containing a URI domain
I3X05_22020	COG1522	sequence-specific DNA binding
I3X05_22035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3X05_22040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3X05_22050	COG0183	Belongs to the thiolase family
I3X05_22080	COG0243	molybdopterin cofactor binding
I3X05_22090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3X05_22095	COG3850	Histidine kinase
I3X05_22100	COG2197	response regulator
I3X05_22110	COG2201	protein-glutamate methylesterase activity
I3X05_22130	COG0516	GMP reductase activity
I3X05_22140	COG1621	beta-fructofuranosidase activity
I3X05_22145	COG0583	DNA-binding transcription factor activity
I3X05_22165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3X05_22170	COG0697	spore germination
I3X05_22175	COG0784	Response regulator, receiver
I3X05_22175	COG3437	response regulator, receiver
I3X05_22185	COG3706	GGDEF domain
I3X05_22190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3X05_22195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3X05_22200	COG1845	cytochrome c oxidase, subunit III
I3X05_22205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I3X05_22220	COG0456	acetyltransferase
I3X05_22225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3X05_22230	COG0662	Cupin 2, conserved barrel domain protein
I3X05_22235	COG0527	aspartate kinase activity
I3X05_22245	COG3634	alkyl hydroperoxide reductase activity
I3X05_22250	COG0450	alkyl hydroperoxide reductase
I3X05_22265	COG1024	Enoyl-CoA hydratase
I3X05_22270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3X05_22275	COG1960	acyl-CoA dehydrogenase activity
I3X05_22285	COG0183	Belongs to the thiolase family
I3X05_22295	COG1960	acyl-CoA dehydrogenase activity
I3X05_22300	COG1024	Enoyl-CoA hydratase
I3X05_22305	COG1024	Enoyl-CoA hydratase
I3X05_22315	COG1028	Short-chain dehydrogenase reductase Sdr
I3X05_22335	COG0583	DNA-binding transcription factor activity
I3X05_22340	COG0477	Major facilitator Superfamily
I3X05_22345	COG0415	Belongs to the DNA photolyase family
I3X05_22350	COG2076	Multidrug Resistance protein
I3X05_22355	COG0519	Catalyzes the synthesis of GMP from XMP
I3X05_22355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3X05_22390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3X05_22400	COG3437	response regulator, receiver
I3X05_22400	COG0784	Response regulator, receiver
I3X05_22405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3X05_22405	COG4191	Histidine kinase
I3X05_22420	COG0443	Heat shock 70 kDa protein
I3X05_22445	COG3530	Putative quorum-sensing-regulated virulence factor
I3X05_22450	COG3226	Transcriptional regulator
I3X05_22490	COG2384	SAM-dependent methyltransferase
I3X05_22495	COG0523	cobalamin synthesis protein
I3X05_22500	COG0513	Belongs to the DEAD box helicase family
I3X05_22515	COG3706	GGDEF domain
I3X05_22525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I3X05_22540	COG0840	transmembrane signaling receptor activity
I3X05_22560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3X05_22565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3X05_22580	COG5001	Diguanylate cyclase
I3X05_22585	COG2897	thiosulfate sulfurtransferase activity
I3X05_22590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3X05_22595	COG0303	'Molybdopterin
I3X05_22600	COG0302	gtp cyclohydrolase
I3X05_22610	COG0038	chloride channel
I3X05_22630	COG4989	oxidoreductase activity
I3X05_22640	COG2195	Cleaves the N-terminal amino acid of tripeptides
I3X05_22650	COG0840	transmembrane signaling receptor activity
I3X05_22660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3X05_22665	COG0545	Peptidyl-prolyl cis-trans isomerase
I3X05_22695	COG1278	Cold shock
I3X05_22700	COG3036	rescue of stalled ribosome
I3X05_22710	COG0840	transmembrane signaling receptor activity
I3X05_22715	COG3706	GGDEF domain
I3X05_22725	COG0583	DNA-binding transcription factor activity
I3X05_22740	COG4166	transmembrane transport
I3X05_22750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3X05_22755	COG0444	Belongs to the ABC transporter superfamily
I3X05_22760	COG4608	Belongs to the ABC transporter superfamily
I3X05_22770	COG1609	Transcriptional regulator
I3X05_22775	COG4580	involved in the transport of maltose and maltodextrins
I3X05_22810	COG4580	involved in the transport of maltose and maltodextrins
I3X05_22820	COG1472	Belongs to the glycosyl hydrolase 3 family
I3X05_22825	COG0534	Mate efflux family protein
I3X05_22840	COG1231	oxidoreductase activity
I3X05_22855	COG0583	DNA-binding transcription factor activity
I3X05_22860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3X05_22870	COG0531	amino acid
I3X05_22880	COG4303	Ethanolamine ammonia lyase large subunit
I3X05_22890	COG1609	Transcriptional regulator
I3X05_22900	COG1175	transmembrane transport
I3X05_22905	COG0395	ABC-type sugar transport system, permease component
I3X05_22910	COG2723	6-phospho-beta-galactosidase activity
I3X05_22915	COG3842	ATPase activity
I3X05_22920	COG3459	Glycosyltransferase 36 associated
I3X05_22925	COG2017	converts alpha-aldose to the beta-anomer
I3X05_22935	COG1609	Transcriptional regulator
I3X05_22940	COG5297	Belongs to the glycosyl hydrolase family 6
I3X05_22940	COG2273	Hydrolase Family 16
I3X05_22970	COG4139	cobalamin transport
I3X05_22975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3X05_22990	COG2130	NADP-dependent
I3X05_22995	COG1309	transcriptional regulator
I3X05_23000	COG0513	Belongs to the DEAD box helicase family
I3X05_23005	COG0589	response to stress
I3X05_23010	COG0659	secondary active sulfate transmembrane transporter activity
I3X05_23015	COG4607	ABC-type enterochelin transport system periplasmic component
I3X05_23020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3X05_23025	COG4605	iron ion homeostasis
I3X05_23030	COG4604	ABC transporter, ATP-binding protein
I3X05_23035	COG0789	Transcriptional regulator
I3X05_23040	COG2207	Transcriptional regulator
I3X05_23040	COG3708	Transcriptional regulator
I3X05_23070	COG1289	transmembrane transporter activity
I3X05_23075	COG0210	DNA helicase
I3X05_23080	COG1803	Methylglyoxal synthase
I3X05_23085	COG1803	Methylglyoxal synthase
I3X05_23090	COG1879	ABC-type sugar transport system periplasmic component
I3X05_23095	COG0784	Response regulator, receiver
I3X05_23095	COG2198	Histidine kinase
I3X05_23095	COG2205	protein histidine kinase activity
I3X05_23115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3X05_23135	COG3069	C4-dicarboxylate transmembrane transporter activity
I3X05_23160	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I3X05_23170	COG3097	Belongs to the UPF0267 family
I3X05_23175	COG4934	collagen metabolic process
I3X05_23185	COG5642	Protein of unknown function (DUF2384)
I3X05_23200	COG4166	transmembrane transport
I3X05_23210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3X05_23215	COG4172	Belongs to the ABC transporter superfamily
I3X05_23305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3X05_23310	COG3715	PTS system
I3X05_23315	COG3716	PTS system mannose fructose sorbose family IID component
I3X05_23350	COG3119	arylsulfatase activity
I3X05_23365	COG0800	Aldolase
I3X05_23370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3X05_23385	COG3119	arylsulfatase activity
I3X05_23390	COG0641	radical SAM
I3X05_23410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I3X05_23415	COG1028	Short-chain dehydrogenase reductase Sdr
I3X05_23435	COG3716	PTS system mannose fructose sorbose family IID component
I3X05_23440	COG3715	PTS system
I3X05_23445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3X05_23450	COG2222	sugar isomerase
I3X05_23460	COG3119	arylsulfatase activity
I3X05_23500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3X05_23530	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I3X05_23535	COG1192	Involved in chromosome partitioning
I3X05_23545	COG3344	reverse transcriptase
I3X05_23560	COG1132	(ABC) transporter
I3X05_23575	COG5433	transposase activity
I3X05_23595	COG2433	Pfam Transposase IS66
I3X05_23655	COG1349	DNA-binding transcription factor activity
I3X05_23670	COG2433	Pfam Transposase IS66
I3X05_23840	COG2433	Pfam Transposase IS66
I3X05_23865	COG1280	lysine exporter protein (LysE YggA)
I3X05_23875	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I3X05_23940	COG0500	methyltransferase