locus-tag	class	description
IF132_00005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IF132_00010	COG2194	sulfuric ester hydrolase activity
IF132_00020	COG2356	endonuclease I
IF132_00035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF132_00065	COG1301	dicarboxylic acid transport
IF132_00090	COG1335	isochorismatase
IF132_00095	COG4977	sequence-specific DNA binding
IF132_00095	COG1917	Cupin 2, conserved barrel domain protein
IF132_00120	COG0456	acetyltransferase
IF132_00145	COG1263	PTS System
IF132_00145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF132_00150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IF132_00155	COG1737	Transcriptional regulator
IF132_00170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IF132_00195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IF132_00210	COG1278	Cold shock
IF132_00230	COG5433	transposase activity
IF132_00245	COG3344	reverse transcriptase
IF132_00285	COG0156	8-amino-7-oxononanoate synthase activity
IF132_00290	COG3240	lipase activity
IF132_00305	COG2211	Major facilitator Superfamily
IF132_00325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IF132_00335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IF132_00340	COG0393	Putative heavy-metal-binding
IF132_00355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IF132_00360	COG0039	L-malate dehydrogenase activity
IF132_00375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF132_00385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IF132_00415	COG2084	Dehydrogenase
IF132_00420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF132_00425	COG0251	oxidation-reduction process
IF132_00450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IF132_00460	COG1737	Transcriptional regulator
IF132_00470	COG1131	(ABC) transporter
IF132_00475	COG0842	Transport permease protein
IF132_00515	COG0513	Belongs to the DEAD box helicase family
IF132_00535	COG1012	belongs to the aldehyde dehydrogenase family
IF132_00540	COG3284	Transcriptional regulator
IF132_00550	COG0625	glutathione transferase activity
IF132_00570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IF132_00575	COG4702	Belongs to the UPF0303 family
IF132_00580	COG0673	inositol 2-dehydrogenase activity
IF132_00585	COG1349	DNA-binding transcription factor activity
IF132_00590	COG0366	Alpha amylase catalytic
IF132_00600	COG2259	Doxx family
IF132_00605	COG1741	Belongs to the pirin family
IF132_00620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF132_00630	COG3437	response regulator, receiver
IF132_00635	COG5002	protein histidine kinase activity
IF132_00635	COG2198	Histidine kinase
IF132_00635	COG0784	Response regulator, receiver
IF132_00655	COG3220	belongs to the UPF0276 family
IF132_00665	COG0564	pseudouridine synthase activity
IF132_00685	COG0642	Histidine kinase
IF132_00715	COG0513	Belongs to the DEAD box helicase family
IF132_00735	COG0784	Response regulator, receiver
IF132_00735	COG2205	protein histidine kinase activity
IF132_00735	COG5002	protein histidine kinase activity
IF132_00770	COG0840	transmembrane signaling receptor activity
IF132_00805	COG1979	alcohol dehydrogenase
IF132_00810	COG1979	alcohol dehydrogenase
IF132_00835	COG0028	Belongs to the TPP enzyme family
IF132_00850	COG2084	Dehydrogenase
IF132_00860	COG0537	adenosine 5'-monophosphoramidase activity
IF132_00865	COG0513	Belongs to the DEAD box helicase family
IF132_00870	COG2188	Transcriptional regulator
IF132_00880	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IF132_00895	COG3457	Alanine racemase
IF132_00900	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IF132_00910	COG1132	(ABC) transporter
IF132_00925	COG1523	belongs to the glycosyl hydrolase 13 family
IF132_00960	COG5001	Diguanylate cyclase
IF132_00970	COG1741	Belongs to the pirin family
IF132_00975	COG5433	transposase activity
IF132_00980	COG1741	Belongs to the pirin family
IF132_00985	COG3123	guanosine phosphorylase activity
IF132_01020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IF132_01025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IF132_01030	COG2169	Transcriptional regulator
IF132_01030	COG1917	Cupin 2, conserved barrel domain protein
IF132_01050	COG0189	ligase activity
IF132_01065	COG0363	glucosamine-6-phosphate deaminase activity
IF132_01075	COG0786	glutamate:sodium symporter activity
IF132_01080	COG0786	glutamate:sodium symporter activity
IF132_01090	COG3279	Response regulator of the LytR AlgR family
IF132_01095	COG3275	phosphorelay sensor kinase activity
IF132_01125	COG0217	transcriptional regulatory protein
IF132_01145	COG3227	Zinc metalloprotease (Elastase)
IF132_01165	COG1444	tRNA N-acetyltransferase activity
IF132_01175	COG0215	cysteine-tRNA ligase activity
IF132_01210	COG0259	pyridoxamine-phosphate oxidase activity
IF132_01235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IF132_01255	COG1999	signal sequence binding
IF132_01265	COG1162	GTPase activity
IF132_01270	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IF132_01300	COG3833	ABC-type maltose transport systems, permease component
IF132_01305	COG1175	transmembrane transport
IF132_01310	COG2182	Extracellular solute-binding protein
IF132_01320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF132_01330	COG3842	ATPase activity
IF132_01345	COG0058	SHG alpha-glucan phosphorylase activity
IF132_01350	COG1640	4-alpha-glucanotransferase
IF132_01355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IF132_01360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IF132_01405	COG2433	Pfam Transposase IS66
IF132_01430	COG1263	PTS System
IF132_01430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF132_01440	COG1621	beta-fructofuranosidase activity
IF132_01445	COG2203	Gaf domain
IF132_01445	COG3706	GGDEF domain
IF132_01445	COG5001	Diguanylate cyclase
IF132_01445	COG4251	negative regulation of phosphorylation
IF132_01450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF132_01455	COG0583	DNA-binding transcription factor activity
IF132_01470	COG3384	dioxygenase
IF132_01480	COG3708	Transcriptional regulator
IF132_01480	COG2207	Transcriptional regulator
IF132_01505	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IF132_01510	COG5433	transposase activity
IF132_01550	COG5433	transposase activity
IF132_01600	COG0625	glutathione transferase activity
IF132_01605	COG1294	oxidase, subunit
IF132_01610	COG1271	oxidase subunit
IF132_01615	COG0583	DNA-binding transcription factor activity
IF132_01620	COG2814	Major facilitator Superfamily
IF132_01625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IF132_01630	COG0583	DNA-binding transcription factor activity
IF132_01640	COG2204	response regulator
IF132_01655	COG0579	oxidoreductase
IF132_01660	COG3047	cAMP biosynthetic process
IF132_01675	COG0625	glutathione transferase activity
IF132_01725	COG0583	DNA-binding transcription factor activity
IF132_01740	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IF132_01765	COG1342	Belongs to the UPF0251 family
IF132_01780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IF132_01785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IF132_01790	COG1653	transport
IF132_01795	COG2205	protein histidine kinase activity
IF132_01820	COG3046	protein related to deoxyribodipyrimidine photolyase
IF132_01830	COG2207	Transcriptional regulator
IF132_01835	COG1881	PFAM PEBP family protein
IF132_01865	COG0488	(ABC) transporter
IF132_01870	COG2375	cellular response to nickel ion
IF132_01875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IF132_01880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IF132_01885	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IF132_01895	COG3842	ATPase activity
IF132_01920	COG2188	Transcriptional regulator
IF132_01945	COG0840	transmembrane signaling receptor activity
IF132_01960	COG3706	GGDEF domain
IF132_01965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF132_01965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF132_01970	COG1765	OsmC-like protein
IF132_01995	COG1011	Hydrolase
IF132_02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF132_02010	COG2207	Transcriptional regulator
IF132_02010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IF132_02015	COG2188	Transcriptional regulator
IF132_02025	COG3104	oligopeptide transport
IF132_02030	COG1760	l-serine dehydratase
IF132_02045	COG1629	transport
IF132_02055	COG1686	Belongs to the peptidase S11 family
IF132_02060	COG1253	flavin adenine dinucleotide binding
IF132_02065	COG1320	monovalent cation:proton antiporter activity
IF132_02070	COG2212	antiporter activity
IF132_02075	COG1863	multisubunit Na H antiporter MnhE subunit
IF132_02085	COG1006	Multisubunit Na H antiporter MnhC subunit
IF132_02090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IF132_02090	COG2111	Na H antiporter
IF132_02100	COG0589	response to stress
IF132_02105	COG0242	peptide deformylase activity
IF132_02115	COG0488	(ABC) transporter
IF132_02125	COG0840	transmembrane signaling receptor activity
IF132_02140	COG0745	RESPONSE REGULATOR receiver
IF132_02155	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF132_02185	COG0189	ligase activity
IF132_02185	COG4067	protein conserved in archaea
IF132_02190	COG0189	ligase activity
IF132_02210	COG1968	undecaprenyl-diphosphatase activity
IF132_02220	COG0668	transmembrane transport
IF132_02235	COG3335	DDE superfamily endonuclease
IF132_02245	COG4160	amino acid transport
IF132_02250	COG4215	(ABC) transporter
IF132_02255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF132_02260	COG1126	abc transporter atp-binding protein
IF132_02265	COG3015	lipoprotein NlpE involved in copper resistance
IF132_02300	COG2814	Major facilitator Superfamily
IF132_02315	COG1304	FMN binding
IF132_02320	COG1620	l-lactate permease
IF132_02325	COG0583	DNA-binding transcription factor activity
IF132_02330	COG1505	serine-type exopeptidase activity
IF132_02335	COG4172	Belongs to the ABC transporter superfamily
IF132_02345	COG1067	ATP-dependent peptidase activity
IF132_02360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IF132_02375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IF132_02380	COG0583	DNA-binding transcription factor activity
IF132_02385	COG0243	molybdopterin cofactor binding
IF132_02395	COG1122	ATPase activity
IF132_02400	COG4720	Psort location CytoplasmicMembrane, score
IF132_02405	COG1566	PFAM secretion protein HlyD family protein
IF132_02430	COG0813	purine-nucleoside phosphorylase activity
IF132_02435	COG3272	Protein of unknown function (DUF1722)
IF132_02445	COG0415	Belongs to the DNA photolyase family
IF132_02450	COG1376	ErfK ybiS ycfS ynhG family protein
IF132_02450	COG1388	LysM domain
IF132_02460	COG0513	Belongs to the DEAD box helicase family
IF132_02465	COG1770	oligopeptidase
IF132_02500	COG0573	inorganic phosphate transmembrane transporter activity
IF132_02505	COG0581	inorganic phosphate transmembrane transporter activity
IF132_02510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IF132_02515	COG3706	GGDEF domain
IF132_02525	COG2304	oxidoreductase activity
IF132_02545	COG0714	Associated with various cellular activities
IF132_02560	COG3842	ATPase activity
IF132_02570	COG1175	transmembrane transport
IF132_02575	COG3833	ABC-type maltose transport systems, permease component
IF132_02605	COG2354	Protein conserved in bacteria
IF132_02615	COG0418	dihydroorotase activity
IF132_02620	COG0633	Ferredoxin
IF132_02620	COG0633	Ferredoxin
IF132_02620	COG3217	Mosc domain protein beta barrel domain protein
IF132_02620	COG3217	Mosc domain protein beta barrel domain protein
IF132_02625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IF132_02630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IF132_02665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IF132_02670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF132_02680	COG0848	biopolymer transport protein
IF132_02685	COG0811	peptide transport
IF132_02690	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IF132_02700	COG3721	Heme iron utilization protein
IF132_02705	COG0748	coenzyme F420 binding
IF132_02715	COG0835	chemotaxis
IF132_02715	COG0784	Response regulator, receiver
IF132_02720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF132_02745	COG0366	Alpha amylase catalytic
IF132_02760	COG3314	Sporulation integral membrane protein YlbJ
IF132_02775	COG0739	heme binding
IF132_02780	COG5001	Diguanylate cyclase
IF132_02785	COG0583	DNA-binding transcription factor activity
IF132_02790	COG2814	Major facilitator Superfamily
IF132_02805	COG0697	spore germination
IF132_02815	COG1764	response to oxidative stress
IF132_02820	COG1846	Transcriptional regulator
IF132_02845	COG1280	lysine exporter protein (LysE YggA)
IF132_02855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF132_02865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IF132_02870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IF132_02885	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IF132_02890	COG0513	Belongs to the DEAD box helicase family
IF132_02895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IF132_02905	COG1028	Short-chain dehydrogenase reductase Sdr
IF132_02920	COG3403	YqcI/YcgG family
IF132_02935	COG1396	sequence-specific DNA binding
IF132_02940	COG3135	benzoate transporter
IF132_02950	COG2113	Glycine betaine
IF132_02955	COG4176	ABC-type proline glycine betaine transport system permease component
IF132_02970	COG1012	belongs to the aldehyde dehydrogenase family
IF132_02990	COG4175	Glycine betaine
IF132_02995	COG1858	cytochrome C peroxidase
IF132_03005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IF132_03010	COG1716	ATPase activity
IF132_03010	COG5001	Diguanylate cyclase
IF132_03030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IF132_03035	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
IF132_03040	COG0247	lactate metabolic process
IF132_03060	COG2133	pyrroloquinoline quinone binding
IF132_03065	COG1454	alcohol dehydrogenase
IF132_03070	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IF132_03095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF132_03100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF132_03105	COG3186	Phenylalanine-4-hydroxylase
IF132_03110	COG2154	pterin-4-alpha-carbinolamine dehydratase
IF132_03125	COG0814	amino acid
IF132_03130	COG2200	EAL domain
IF132_03130	COG2199	diguanylate cyclase activity
IF132_03135	COG0312	modulator of DNA gyrase
IF132_03140	COG0312	modulator of DNA gyrase
IF132_03145	COG0584	glycerophosphoryl diester phosphodiesterase
IF132_03150	COG2271	Major facilitator Superfamily
IF132_03180	COG0456	acetyltransferase
IF132_03190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IF132_03195	COG0515	serine threonine protein kinase
IF132_03195	COG2815	serine threonine protein kinase
IF132_03230	COG0631	protein serine/threonine phosphatase activity
IF132_03345	COG0667	Aldo Keto reductase
IF132_03350	COG2814	Major facilitator Superfamily
IF132_03365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF132_03390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IF132_03400	COG0765	amino acid transport
IF132_03405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF132_03415	COG1126	abc transporter atp-binding protein
IF132_03425	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IF132_03445	COG2315	Protein conserved in bacteria
IF132_03460	COG1869	D-ribose catabolic process
IF132_03465	COG1129	ABC transporter
IF132_03470	COG1172	Belongs to the binding-protein-dependent transport system permease family
IF132_03475	COG1879	ABC-type sugar transport system periplasmic component
IF132_03480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF132_03485	COG1609	Transcriptional regulator
IF132_03490	COG0784	Response regulator, receiver
IF132_03490	COG0835	chemotaxis
IF132_03540	COG4211	Belongs to the binding-protein-dependent transport system permease family
IF132_03565	COG3344	reverse transcriptase
IF132_03585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF132_03585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF132_03590	COG0509	glycine decarboxylation via glycine cleavage system
IF132_03595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IF132_03605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IF132_03620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF132_03635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF132_03635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF132_03635	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IF132_03640	COG1105	Belongs to the carbohydrate kinase PfkB family
IF132_03645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF132_03645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF132_03650	COG1609	Transcriptional regulator
IF132_03670	COG1979	alcohol dehydrogenase
IF132_03675	COG2207	Transcriptional regulator
IF132_03690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IF132_03695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF132_03720	COG0840	transmembrane signaling receptor activity
IF132_03720	COG3290	protein histidine kinase activity
IF132_03730	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IF132_03735	COG2197	response regulator
IF132_03740	COG3850	Histidine kinase
IF132_03745	COG2223	nitrite transmembrane transporter activity
IF132_03750	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IF132_03755	COG1140	nitrate reductase beta subunit
IF132_03760	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IF132_03765	COG2181	nitrate reductase activity
IF132_03785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF132_03790	COG0840	transmembrane signaling receptor activity
IF132_03800	COG0513	Belongs to the DEAD box helicase family
IF132_03815	COG3038	cytochrome b561
IF132_03820	COG2353	YceI-like domain
IF132_03825	COG2116	formate transmembrane transporter activity
IF132_03830	COG0583	DNA-binding transcription factor activity
IF132_03840	COG3593	DNA synthesis involved in DNA repair
IF132_03845	COG0737	Belongs to the 5'-nucleotidase family
IF132_03850	COG0861	Integral membrane protein TerC family
IF132_03870	COG2267	carboxylic ester hydrolase activity
IF132_03875	COG2067	long-chain fatty acid transport protein
IF132_03880	COG0750	zinc metalloprotease
IF132_03890	COG2050	protein possibly involved in aromatic compounds catabolism
IF132_03900	COG4533	DNA binding
IF132_03905	COG0366	Alpha amylase catalytic
IF132_03915	COG1324	tolerance protein
IF132_03930	COG0484	heat shock protein binding
IF132_03945	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IF132_03955	COG4181	ATPase activity
IF132_03960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IF132_03965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF132_03965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IF132_03970	COG1984	allophanate hydrolase subunit 2
IF132_03980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IF132_04005	COG0583	DNA-binding transcription factor activity
IF132_04010	COG1042	CoA-binding domain protein
IF132_04010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IF132_04010	COG0045	succinate-CoA ligase (ADP-forming) activity
IF132_04035	COG0023	Translation Initiation Factor
IF132_04040	COG3140	Belongs to the UPF0181 family
IF132_04065	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IF132_04070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IF132_04090	COG3706	GGDEF domain
IF132_04095	COG2433	Pfam Transposase IS66
IF132_04110	COG0745	RESPONSE REGULATOR receiver
IF132_04120	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IF132_04125	COG4149	molybdate abc transporter
IF132_04130	COG0725	ABC transporter, periplasmic molybdate-binding protein
IF132_04150	COG0189	ligase activity
IF132_04150	COG4067	protein conserved in archaea
IF132_04160	COG0602	queuosine metabolic process
IF132_04165	COG1328	CTP reductase activity
IF132_04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF132_04210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IF132_04215	COG3118	belongs to the thioredoxin family
IF132_04245	COG0840	transmembrane signaling receptor activity
IF132_04250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IF132_04265	COG0848	biopolymer transport protein
IF132_04270	COG0811	peptide transport
IF132_04275	COG0811	peptide transport
IF132_04295	COG0840	transmembrane signaling receptor activity
IF132_04340	COG4172	Belongs to the ABC transporter superfamily
IF132_04345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF132_04355	COG4166	transmembrane transport
IF132_04370	COG5642	Protein of unknown function (DUF2384)
IF132_04430	COG4964	Belongs to the GSP D family
IF132_04450	COG0583	DNA-binding transcription factor activity
IF132_04470	COG3097	Belongs to the UPF0267 family
IF132_04480	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IF132_04505	COG3069	C4-dicarboxylate transmembrane transporter activity
IF132_04540	COG0322	excinuclease ABC activity
IF132_04545	COG0784	Response regulator, receiver
IF132_04545	COG2205	protein histidine kinase activity
IF132_04545	COG2198	Histidine kinase
IF132_04550	COG1879	ABC-type sugar transport system periplasmic component
IF132_04555	COG1803	Methylglyoxal synthase
IF132_04560	COG1803	Methylglyoxal synthase
IF132_04565	COG0210	DNA helicase
IF132_04570	COG1289	transmembrane transporter activity
IF132_04595	COG1629	transport
IF132_04595	COG4771	TonB-dependent receptor
IF132_04600	COG3708	Transcriptional regulator
IF132_04600	COG2207	Transcriptional regulator
IF132_04605	COG0789	Transcriptional regulator
IF132_04610	COG4604	ABC transporter, ATP-binding protein
IF132_04615	COG4605	iron ion homeostasis
IF132_04620	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF132_04625	COG4607	ABC-type enterochelin transport system periplasmic component
IF132_04640	COG0659	secondary active sulfate transmembrane transporter activity
IF132_04645	COG0589	response to stress
IF132_04650	COG0513	Belongs to the DEAD box helicase family
IF132_04655	COG1309	transcriptional regulator
IF132_04660	COG2130	NADP-dependent
IF132_04675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IF132_04680	COG4139	cobalamin transport
IF132_04690	COG0840	transmembrane signaling receptor activity
IF132_04710	COG2273	Hydrolase Family 16
IF132_04710	COG5297	Belongs to the glycosyl hydrolase family 6
IF132_04715	COG1609	Transcriptional regulator
IF132_04725	COG2017	converts alpha-aldose to the beta-anomer
IF132_04730	COG3459	Glycosyltransferase 36 associated
IF132_04735	COG3842	ATPase activity
IF132_04740	COG2723	6-phospho-beta-galactosidase activity
IF132_04745	COG0395	ABC-type sugar transport system, permease component
IF132_04750	COG1175	transmembrane transport
IF132_04760	COG1609	Transcriptional regulator
IF132_04770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IF132_04775	COG0583	DNA-binding transcription factor activity
IF132_04780	COG0534	Mate efflux family protein
IF132_04800	COG0583	DNA-binding transcription factor activity
IF132_04815	COG0840	transmembrane signaling receptor activity
IF132_04835	COG3036	rescue of stalled ribosome
IF132_04840	COG1278	Cold shock
IF132_04870	COG0545	Peptidyl-prolyl cis-trans isomerase
IF132_04875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF132_04895	COG2195	Cleaves the N-terminal amino acid of tripeptides
IF132_04905	COG4989	oxidoreductase activity
IF132_04920	COG0038	chloride channel
IF132_04930	COG0302	gtp cyclohydrolase
IF132_04940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IF132_04945	COG2897	thiosulfate sulfurtransferase activity
IF132_04950	COG5001	Diguanylate cyclase
IF132_04965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IF132_04980	COG0840	transmembrane signaling receptor activity
IF132_04990	COG2205	protein histidine kinase activity
IF132_04990	COG4999	Histidine kinase
IF132_04990	COG3437	response regulator, receiver
IF132_04990	COG3850	Histidine kinase
IF132_04995	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IF132_05005	COG3706	GGDEF domain
IF132_05020	COG0513	Belongs to the DEAD box helicase family
IF132_05025	COG0523	cobalamin synthesis protein
IF132_05030	COG2384	SAM-dependent methyltransferase
IF132_05035	COG1902	pentaerythritol trinitrate reductase activity
IF132_05050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF132_05055	COG3530	Putative quorum-sensing-regulated virulence factor
IF132_05080	COG0443	Heat shock 70 kDa protein
IF132_05095	COG4191	Histidine kinase
IF132_05095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF132_05100	COG0784	Response regulator, receiver
IF132_05100	COG3437	response regulator, receiver
IF132_05110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IF132_05150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IF132_05150	COG0519	Catalyzes the synthesis of GMP from XMP
IF132_05155	COG2076	Multidrug Resistance protein
IF132_05160	COG0415	Belongs to the DNA photolyase family
IF132_05165	COG0477	Major facilitator Superfamily
IF132_05170	COG0583	DNA-binding transcription factor activity
IF132_05190	COG1028	Short-chain dehydrogenase reductase Sdr
IF132_05200	COG1024	Enoyl-CoA hydratase
IF132_05205	COG1024	Enoyl-CoA hydratase
IF132_05210	COG1960	acyl-CoA dehydrogenase activity
IF132_05220	COG0183	Belongs to the thiolase family
IF132_05230	COG1960	acyl-CoA dehydrogenase activity
IF132_05235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IF132_05240	COG1024	Enoyl-CoA hydratase
IF132_05255	COG0450	alkyl hydroperoxide reductase
IF132_05275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF132_05280	COG0640	Transcriptional regulator
IF132_05295	COG0527	aspartate kinase activity
IF132_05300	COG0662	Cupin 2, conserved barrel domain protein
IF132_05305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IF132_05310	COG0456	acetyltransferase
IF132_05325	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IF132_05330	COG1845	cytochrome c oxidase, subunit III
IF132_05335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IF132_05340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IF132_05345	COG3706	GGDEF domain
IF132_05355	COG0697	spore germination
IF132_05360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF132_05365	COG0840	transmembrane signaling receptor activity
IF132_05405	COG0516	GMP reductase activity
IF132_05415	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IF132_05415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IF132_05425	COG2201	protein-glutamate methylesterase activity
IF132_05435	COG2197	response regulator
IF132_05440	COG3850	Histidine kinase
IF132_05445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IF132_05455	COG0243	molybdopterin cofactor binding
IF132_05505	COG0183	Belongs to the thiolase family
IF132_05515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF132_05520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF132_05535	COG1522	sequence-specific DNA binding
IF132_05565	COG2827	Endonuclease containing a URI domain
IF132_05570	COG3132	Protein of unknown function, DUF480
IF132_05580	COG2926	Belongs to the UPF0265 family
IF132_05585	COG0534	Mate efflux family protein
IF132_05605	COG0583	DNA-binding transcription factor activity
IF132_05610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IF132_05635	COG0531	amino acid
IF132_05640	COG0121	glutamine amidotransferase
IF132_05645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF132_05655	COG2207	Transcriptional regulator
IF132_05660	COG2239	Acts as a magnesium transporter
IF132_05675	COG0668	transmembrane transport
IF132_05725	COG0351	phosphomethylpyrimidine kinase
IF132_05730	COG0671	phosphoesterase, PA-phosphatase related
IF132_05745	COG0561	phosphatase activity
IF132_05755	COG4533	DNA binding
IF132_05760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IF132_05765	COG0076	glutamate decarboxylase activity
IF132_05780	COG2910	NAD(P)H-binding
IF132_05785	COG0745	RESPONSE REGULATOR receiver
IF132_05790	COG2205	protein histidine kinase activity
IF132_06275	COG3549	Plasmid maintenance system killer
IF132_06280	COG3093	addiction module antidote protein HigA
IF132_06360	COG5433	transposase activity
IF132_06365	COG0251	oxidation-reduction process
IF132_06510	COG5433	transposase activity
IF132_06970	COG0454	-acetyltransferase
IF132_07020	COG2161	toxin-antitoxin pair type II binding
IF132_07025	COG4115	mRNA cleavage
IF132_07450	COG3041	Addiction module toxin RelE StbE family
IF132_07545	COG0454	-acetyltransferase
IF132_07560	COG5433	transposase activity
IF132_07585	COG5433	transposase activity
IF132_07680	COG2433	Pfam Transposase IS66
IF132_07845	COG5433	transposase activity
IF132_07910	COG5433	transposase activity
IF132_07920	COG2433	Pfam Transposase IS66
IF132_07955	COG5433	transposase activity
IF132_07980	COG2944	sequence-specific DNA binding
IF132_07985	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IF132_08005	COG2433	Pfam Transposase IS66
IF132_08040	COG2723	6-phospho-beta-galactosidase activity
IF132_08045	COG1609	Transcriptional regulator
IF132_08050	COG0584	glycerophosphoryl diester phosphodiesterase
IF132_08070	COG1793	dna ligase
IF132_08080	COG0534	Mate efflux family protein
IF132_08085	COG0307	riboflavin synthase, alpha
IF132_08105	COG3706	GGDEF domain
IF132_08115	COG0791	NLP P60 protein
IF132_08120	COG0840	transmembrane signaling receptor activity
IF132_08130	COG3148	PFAM DTW domain containing protein
IF132_08135	COG1940	carbohydrate kinase activity
IF132_08145	COG1763	Mo-molybdopterin cofactor biosynthetic process
IF132_08150	COG0746	molybdenum cofactor guanylyltransferase activity
IF132_08155	COG0488	(ABC) transporter
IF132_08160	COG0004	ammonium transporteR
IF132_08165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IF132_08170	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IF132_08175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IF132_08180	COG1177	transmembrane transport
IF132_08190	COG3842	ATPase activity
IF132_08200	COG2992	FlgJ-related protein
IF132_08215	COG0589	response to stress
IF132_08220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF132_08235	COG2217	Heavy metal translocating P-type atpase
IF132_08245	COG2010	Cytochrome c
IF132_08260	COG3278	Belongs to the heme-copper respiratory oxidase family
IF132_08275	COG0784	Response regulator, receiver
IF132_08275	COG2205	protein histidine kinase activity
IF132_08295	COG3120	sequence-specific DNA binding
IF132_08300	COG1067	ATP-dependent peptidase activity
IF132_08305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF132_08320	COG0488	(ABC) transporter
IF132_08330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF132_08330	COG0116	Belongs to the methyltransferase superfamily
IF132_08340	COG0167	dihydroorotate dehydrogenase activity
IF132_08355	COG0308	aminopeptidase N
IF132_08370	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IF132_08375	COG1956	GAF domain-containing protein
IF132_08380	COG1132	(ABC) transporter
IF132_08385	COG2995	paraquat-inducible protein a
IF132_08390	COG3008	intermembrane lipid transfer
IF132_08395	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IF132_08395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IF132_08400	COG2996	Protein conserved in bacteria
IF132_08425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IF132_08440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF132_08445	COG4597	amino acid ABC transporter
IF132_08450	COG0765	amino acid transport
IF132_08455	COG1126	abc transporter atp-binding protein
IF132_08460	COG0670	Belongs to the BI1 family
IF132_08465	COG2920	part of a sulfur-relay system
IF132_08470	COG1254	Belongs to the acylphosphatase family
IF132_08480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF132_08505	COG3706	GGDEF domain
IF132_08510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IF132_08515	COG0602	queuosine metabolic process
IF132_08520	COG0561	phosphatase activity
IF132_08540	COG2828	Protein conserved in bacteria
IF132_08545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IF132_08550	COG0372	Belongs to the citrate synthase family
IF132_08555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IF132_08580	COG0730	response to heat
IF132_08595	COG1278	Cold shock
IF132_08615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF132_08645	COG0625	glutathione transferase activity
IF132_08655	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IF132_08665	COG2146	nitrite reductase [NAD(P)H] activity
IF132_08670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF132_08670	COG2146	nitrite reductase [NAD(P)H] activity
IF132_08675	COG1116	anion transmembrane transporter activity
IF132_08680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF132_08685	COG1116	anion transmembrane transporter activity
IF132_08685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IF132_08690	COG3707	response regulator
IF132_08695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IF132_08700	COG1648	precorrin-2 dehydrogenase activity
IF132_08700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IF132_08705	COG0243	molybdopterin cofactor binding
IF132_08715	COG3063	Type IV pilus biogenesis stability protein PilW
IF132_08730	COG1451	nucleotide metabolic process
IF132_08760	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IF132_08770	COG2988	succinylglutamate desuccinylase activity
IF132_08790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IF132_08800	COG0702	epimerase
IF132_08805	COG2925	Exonuclease
IF132_08810	COG1380	Effector of murein hydrolase LrgA
IF132_08815	COG1346	cytolysis
IF132_08820	COG0295	cytidine deaminase activity
IF132_08825	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IF132_08830	COG0500	methyltransferase
IF132_08840	COG0776	regulation of translation
IF132_08860	COG2200	EAL domain
IF132_08870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF132_08870	COG0072	phenylalanine-tRNA ligase activity
IF132_08875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IF132_08925	COG1166	arginine decarboxylase activity
IF132_08930	COG0010	Belongs to the arginase family
IF132_08935	COG2814	Major facilitator Superfamily
IF132_08945	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IF132_08970	COG1643	Atp-dependent helicase
IF132_08975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IF132_09010	COG0443	Heat shock 70 kDa protein
IF132_09015	COG0443	Heat shock 70 kDa protein
IF132_09020	COG1280	lysine exporter protein (LysE YggA)
IF132_09035	COG3568	Endonuclease Exonuclease Phosphatase
IF132_09045	COG3706	GGDEF domain
IF132_09055	COG1132	(ABC) transporter
IF132_09060	COG1132	(ABC) transporter
IF132_09075	COG0783	Belongs to the Dps family
IF132_09085	COG0814	amino acid
IF132_09095	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IF132_09110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IF132_09115	COG1328	CTP reductase activity
IF132_09120	COG3300	MHYT domain
IF132_09120	COG5001	Diguanylate cyclase
IF132_09135	COG5001	Diguanylate cyclase
IF132_09140	COG3706	GGDEF domain
IF132_09145	COG2204	response regulator
IF132_09150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF132_09150	COG4191	Histidine kinase
IF132_09155	COG0471	metal ion transport
IF132_09170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IF132_09180	COG3768	UPF0283 membrane protein
IF132_09185	COG3106	COG3106 Predicted ATPase
IF132_09205	COG0494	nUDIX hydrolase
IF132_09210	COG0814	amino acid
IF132_09215	COG1760	l-serine dehydratase
IF132_09220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF132_09225	COG0577	efflux transmembrane transporter activity
IF132_09225	COG1136	(ABC) transporter
IF132_09235	COG0720	synthase
IF132_09240	COG0840	transmembrane signaling receptor activity
IF132_09245	COG0017	Asparaginyl-tRNA synthetase
IF132_09265	COG2770	Histidine kinase
IF132_09265	COG3437	response regulator, receiver
IF132_09270	COG1448	Aminotransferase
IF132_09295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IF132_09300	COG1846	Transcriptional regulator
IF132_09325	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IF132_09340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IF132_09345	COG3108	Peptidase M15
IF132_09350	COG2989	Protein conserved in bacteria
IF132_09375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IF132_09395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF132_09400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IF132_09470	COG0322	excinuclease ABC activity
IF132_09475	COG2197	response regulator
IF132_09480	COG0417	DNA replication proofreading
IF132_09485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IF132_09495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IF132_09510	COG0009	L-threonylcarbamoyladenylate synthase
IF132_09515	COG0613	PHP domain protein
IF132_09525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IF132_09530	COG0512	Glutamine amidotransferase of anthranilate synthase
IF132_09540	COG0135	phosphoribosylanthranilate isomerase activity
IF132_09540	COG0134	indole-3-glycerol-phosphate synthase activity
IF132_09545	COG0133	tryptophan synthase activity
IF132_09550	COG0159	tryptophan synthase activity
IF132_09575	COG2350	Protein conserved in bacteria
IF132_09590	COG0583	DNA-binding transcription factor activity
IF132_09660	COG2199	diguanylate cyclase activity
IF132_09660	COG2203	Gaf domain
IF132_09665	COG0415	Belongs to the DNA photolyase family
IF132_09695	COG1858	cytochrome C peroxidase
IF132_09705	COG2197	response regulator
IF132_09710	COG3851	Histidine kinase
IF132_09715	COG2271	Major facilitator Superfamily
IF132_09720	COG1482	cell wall glycoprotein biosynthetic process
IF132_09750	COG0732	type I restriction modification DNA specificity domain
IF132_09755	COG0732	type I restriction modification DNA specificity domain
IF132_09770	COG1715	Restriction endonuclease
IF132_09815	COG5002	protein histidine kinase activity
IF132_09815	COG0784	Response regulator, receiver
IF132_09835	COG1858	cytochrome C peroxidase
IF132_09855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IF132_09860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IF132_09865	COG2885	chlorophyll binding
IF132_09870	COG0823	Involved in the tonB-independent uptake of proteins
IF132_09885	COG0811	peptide transport
IF132_09890	COG0824	Thioesterase
IF132_09900	COG4890	Cyd operon protein YbgT
IF132_09905	COG1294	oxidase, subunit
IF132_09910	COG1271	oxidase subunit
IF132_09915	COG2255	four-way junction helicase activity
IF132_09920	COG0632	four-way junction helicase activity
IF132_09925	COG0840	transmembrane signaling receptor activity
IF132_09940	COG1801	Protein of unknown function DUF72
IF132_09950	COG0500	methyltransferase
IF132_09955	COG4067	protein conserved in archaea
IF132_09955	COG0189	ligase activity
IF132_09975	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IF132_09980	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IF132_09990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF132_09995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IF132_10000	COG0745	RESPONSE REGULATOR receiver
IF132_10005	COG3381	protein complex oligomerization
IF132_10010	COG1609	Transcriptional regulator
IF132_10015	COG3070	regulator of competence-specific genes
IF132_10035	COG0297	glycogen (starch) synthase activity
IF132_10040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IF132_10045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IF132_10055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IF132_10070	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IF132_10075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IF132_10080	COG0542	response to heat
IF132_10090	COG1278	Cold shock
IF132_10105	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IF132_10115	COG1199	ATP-dependent helicase activity
IF132_10125	COG3923	Primosomal replication protein n
IF132_10135	COG0840	transmembrane signaling receptor activity
IF132_10140	COG0708	Exodeoxyribonuclease III
IF132_10145	COG4160	amino acid transport
IF132_10175	COG1882	Formate acetyltransferase
IF132_10185	COG0840	transmembrane signaling receptor activity
IF132_10190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IF132_10200	COG3013	Belongs to the UPF0304 family
IF132_10205	COG2766	serine protein kinase
IF132_10210	COG2718	Belongs to the UPF0229 family
IF132_10215	COG2719	SpoVR family
IF132_10220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IF132_10225	COG2835	tetraacyldisaccharide 4'-kinase activity
IF132_10230	COG1663	tetraacyldisaccharide 4'-kinase activity
IF132_10235	COG1132	(ABC) transporter
IF132_10240	COG2333	competence protein COMEC
IF132_10240	COG0658	competence protein
IF132_10250	COG4591	ABC-type transport system involved in lipoprotein release permease component
IF132_10255	COG1136	(ABC) transporter
IF132_10260	COG4591	ABC-type transport system involved in lipoprotein release permease component
IF132_10270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IF132_10285	COG1054	Belongs to the UPF0176 family
IF132_10290	COG1252	NADH dehydrogenase
IF132_10320	COG0537	adenosine 5'-monophosphoramidase activity
IF132_10335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IF132_10345	COG0517	IMP dehydrogenase activity
IF132_10345	COG0617	tRNA 3'-terminal CCA addition
IF132_10345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IF132_10360	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IF132_10365	COG1518	maintenance of DNA repeat elements
IF132_10410	COG4584	PFAM Integrase catalytic
IF132_10415	COG1484	DNA-dependent DNA replication
IF132_10425	COG3344	reverse transcriptase
IF132_10450	COG2433	Pfam Transposase IS66
IF132_10485	COG2433	Pfam Transposase IS66
IF132_10495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IF132_10580	COG1946	Acyl-CoA thioesterase
IF132_10585	COG1522	sequence-specific DNA binding
IF132_10600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF132_10640	COG0477	Major facilitator Superfamily
IF132_10665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IF132_10670	COG0596	Alpha beta hydrolase
IF132_10675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IF132_10680	COG1169	isochorismate synthase
IF132_10685	COG0436	Aminotransferase
IF132_10690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IF132_10695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IF132_10715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF132_10720	COG0776	regulation of translation
IF132_10725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IF132_10730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IF132_10755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IF132_10760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IF132_10770	COG3842	ATPase activity
IF132_10775	COG0395	ABC-type sugar transport system, permease component
IF132_10780	COG1175	transmembrane transport
IF132_10835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF132_10840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF132_10860	COG1216	Glycosyl transferase, family 2
IF132_10865	COG2986	histidine ammonia-lyase
IF132_10900	COG1028	Short-chain dehydrogenase reductase Sdr
IF132_10915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IF132_10920	COG0583	DNA-binding transcription factor activity
IF132_10930	COG3100	YcgL domain-containing protein
IF132_10935	COG0850	regulation of cytokinetic process
IF132_10940	COG2894	cell division
IF132_10945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IF132_10950	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IF132_10955	COG0318	PFAM AMP-dependent synthetase and ligase
IF132_10960	COG2267	carboxylic ester hydrolase activity
IF132_10965	COG3065	identical protein binding
IF132_10975	COG1214	PFAM Peptidase M22, glycoprotease
IF132_10980	COG1199	ATP-dependent helicase activity
IF132_10990	COG0788	formyltetrahydrofolate deformylase activity
IF132_10995	COG3102	Protein conserved in bacteria
IF132_11015	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IF132_11020	COG1918	ferrous iron import across plasma membrane
IF132_11030	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IF132_11035	COG1121	(ABC) transporter
IF132_11040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IF132_11055	COG0508	dehydrogenase complex catalyzes the overall conversion of
IF132_11060	COG0567	Dehydrogenase, E1 component
IF132_11070	COG1053	succinate dehydrogenase
IF132_11075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IF132_11090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IF132_11100	COG0033	Phosphoglucomutase
IF132_11105	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IF132_11110	COG0596	Alpha beta hydrolase
IF132_11120	COG0716	FMN binding
IF132_11125	COG1346	cytolysis
IF132_11130	COG1380	Effector of murein hydrolase LrgA
IF132_11135	COG0583	DNA-binding transcription factor activity
IF132_11150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF132_11155	COG1263	PTS System
IF132_11155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF132_11155	COG2190	(PTS) system
IF132_11160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IF132_11165	COG1846	Transcriptional regulator
IF132_11165	COG1940	carbohydrate kinase activity
IF132_11175	COG0367	asparagine synthase
IF132_11185	COG3104	oligopeptide transport
IF132_11190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IF132_11200	COG0326	Molecular chaperone. Has ATPase activity
IF132_11205	COG3710	Transcriptional regulator
IF132_11225	COG0622	Phosphoesterase
IF132_11250	COG1090	epimerase
IF132_11255	COG0300	oxidoreductase activity
IF132_11260	COG3118	belongs to the thioredoxin family
IF132_11265	COG0330	HflC and HflK could
IF132_11295	COG2433	Pfam Transposase IS66
IF132_11310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IF132_11320	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IF132_11325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IF132_11330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF132_11335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IF132_11340	COG2190	(PTS) system
IF132_11345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF132_11350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF132_11355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF132_11360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF132_11370	COG1705	Flagellar rod assembly protein muramidase FlgJ
IF132_11370	COG3951	Flagellar rod assembly protein muramidase FlgJ
IF132_11375	COG1706	bacterial-type flagellum-dependent cell motility
IF132_11390	COG4787	bacterial-type flagellum-dependent cell motility
IF132_11410	COG1815	bacterial-type flagellum-dependent cell motility
IF132_11415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IF132_11420	COG0835	chemotaxis
IF132_11420	COG0784	Response regulator, receiver
IF132_11470	COG2608	mercury ion transmembrane transporter activity
IF132_11470	COG2217	Heavy metal translocating P-type atpase
IF132_11500	COG2840	Smr protein MutS2
IF132_11505	COG1187	pseudouridine synthase activity
IF132_11510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IF132_11520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IF132_11525	COG2912	Transglutaminase-like superfamily
IF132_11535	COG2890	protein-(glutamine-N5) methyltransferase activity
IF132_11540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IF132_11550	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IF132_11560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IF132_11565	COG0193	aminoacyl-tRNA hydrolase activity
IF132_11660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF132_11665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IF132_11670	COG1702	phosphate starvation-inducible protein PhoH
IF132_11675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IF132_11680	COG4535	Mg2 and Co2 transporter CorC
IF132_11690	COG2888	peptidyl-tyrosine sulfation
IF132_11700	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IF132_11705	COG1466	dna polymerase III delta subunit
IF132_11710	COG0799	negative regulation of ribosome biogenesis
IF132_11715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IF132_11720	COG0768	penicillin binding
IF132_11725	COG0772	Belongs to the SEDS family
IF132_11730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IF132_11735	COG1686	Belongs to the peptidase S11 family
IF132_11740	COG2921	Belongs to the UPF0250 family
IF132_11745	COG0321	lipoyl(octanoyl) transferase activity
IF132_11750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IF132_11760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IF132_11770	COG0366	Alpha amylase catalytic
IF132_11775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF132_11775	COG1263	PTS System
IF132_11780	COG1609	Transcriptional regulator
IF132_11785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IF132_11790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IF132_11795	COG2011	ABC-type metal ion transport system permease component
IF132_11800	COG1464	Belongs to the NlpA lipoprotein family
IF132_11805	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IF132_11815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IF132_11815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IF132_11830	COG1611	Belongs to the LOG family
IF132_11835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF132_11845	COG2363	Small membrane protein
IF132_11855	COG0583	DNA-binding transcription factor activity
IF132_11860	COG0301	tRNA thio-modification
IF132_11860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF132_11870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IF132_11875	COG1722	exodeoxyribonuclease VII activity
IF132_11880	COG0142	geranyltranstransferase activity
IF132_11885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IF132_11890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IF132_11900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IF132_11905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IF132_11920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IF132_11920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IF132_11925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IF132_11930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IF132_11935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IF132_11945	COG1073	alpha beta
IF132_11950	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IF132_11955	COG2252	PERMEase
IF132_11960	COG2195	Cleaves the N-terminal amino acid of tripeptides
IF132_11985	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IF132_11990	COG0590	tRNA wobble adenosine to inosine editing
IF132_11995	COG0583	DNA-binding transcription factor activity
IF132_12000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IF132_12010	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IF132_12040	COG0484	heat shock protein binding
IF132_12045	COG0443	Heat shock 70 kDa protein
IF132_12055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IF132_12065	COG0497	DNA recombination
IF132_12070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF132_12075	COG2914	Belongs to the UPF0125 (RnfH) family
IF132_12080	COG2867	negative regulation of translational initiation
IF132_12085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IF132_12100	COG0697	spore germination
IF132_12115	COG0009	L-threonylcarbamoyladenylate synthase
IF132_12140	COG1115	amino acid carrier protein
IF132_12145	COG1584	GPR1 FUN34 yaaH family protein
IF132_12155	COG0519	Catalyzes the synthesis of GMP from XMP
IF132_12155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IF132_12160	COG0516	GMP reductase activity
IF132_12160	COG0517	IMP dehydrogenase activity
IF132_12175	COG2203	Gaf domain
IF132_12175	COG2199	diguanylate cyclase activity
IF132_12180	COG1160	GTP binding
IF132_12185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF132_12190	COG2976	Protein conserved in bacteria
IF132_12195	COG0124	histidyl-tRNA synthetase
IF132_12200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IF132_12205	COG1426	Protein conserved in bacteria
IF132_12215	COG0105	UTP biosynthetic process
IF132_12220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IF132_12225	COG2975	iron-sulfur cluster assembly
IF132_12230	COG0633	Ferredoxin
IF132_12235	COG0443	Heat shock 70 kDa protein
IF132_12240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IF132_12245	COG0316	Belongs to the HesB IscA family
IF132_12250	COG0822	iron-sulfur transferase activity
IF132_12260	COG1959	2 iron, 2 sulfur cluster binding
IF132_12265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IF132_12270	COG0483	inositol monophosphate 1-phosphatase activity
IF132_12275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF132_12280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF132_12285	COG1862	Preprotein translocase
IF132_12290	COG0343	queuine tRNA-ribosyltransferase activity
IF132_12295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IF132_12305	COG0517	IMP dehydrogenase activity
IF132_12315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IF132_12320	COG0583	DNA-binding transcription factor activity
IF132_12325	COG0450	alkyl hydroperoxide reductase
IF132_12340	COG0704	Plays a role in the regulation of phosphate uptake
IF132_12345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IF132_12350	COG0581	inorganic phosphate transmembrane transporter activity
IF132_12365	COG0248	Ppx GppA phosphatase
IF132_12375	COG5002	protein histidine kinase activity
IF132_12380	COG0745	RESPONSE REGULATOR receiver
IF132_12390	COG0826	peptidase U32
IF132_12395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IF132_12455	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF132_12460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IF132_12465	COG1605	Chorismate mutase
IF132_12465	COG0077	Prephenate dehydratase
IF132_12470	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IF132_12475	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IF132_12485	COG0488	(ABC) transporter
IF132_12495	COG0739	heme binding
IF132_12500	COG1605	Chorismate mutase
IF132_12500	COG0287	Prephenate dehydrogenase
IF132_12510	COG1472	Belongs to the glycosyl hydrolase 3 family
IF132_12515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IF132_12535	COG1966	Carbon starvation protein
IF132_12540	COG3275	phosphorelay sensor kinase activity
IF132_12550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IF132_12555	COG1047	Peptidyl-prolyl cis-trans
IF132_12560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IF132_12565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IF132_12570	COG0196	riboflavin kinase activity
IF132_12575	COG0728	peptidoglycan biosynthetic process
IF132_12580	COG0268	Binds directly to 16S ribosomal RNA
IF132_12585	COG0640	Transcriptional regulator
IF132_12590	COG0583	DNA-binding transcription factor activity
IF132_12595	COG1283	sodium-dependent phosphate transmembrane transporter activity
IF132_12625	COG0494	nUDIX hydrolase
IF132_12630	COG3066	DNA modification
IF132_12640	COG0667	Aldo Keto reductase
IF132_12650	COG2204	response regulator
IF132_12655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IF132_12665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IF132_12670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF132_12675	COG4974	Belongs to the 'phage' integrase family
IF132_12690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IF132_12695	COG0513	Belongs to the DEAD box helicase family
IF132_12700	COG3022	response to hydroperoxide
IF132_12705	COG1115	amino acid carrier protein
IF132_12720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IF132_12735	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IF132_12740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IF132_12745	COG0083	homoserine kinase activity
IF132_12760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IF132_12770	COG0745	RESPONSE REGULATOR receiver
IF132_12780	COG5002	protein histidine kinase activity
IF132_12780	COG2198	Histidine kinase
IF132_12780	COG0784	Response regulator, receiver
IF132_12785	COG5001	Diguanylate cyclase
IF132_12785	COG3706	GGDEF domain
IF132_12785	COG2203	Gaf domain
IF132_12785	COG4251	negative regulation of phosphorylation
IF132_12790	COG1242	4 iron, 4 sulfur cluster binding
IF132_12795	COG0067	glutamate synthase
IF132_12795	COG0070	glutamate synthase
IF132_12795	COG0069	glutamate synthase activity
IF132_12805	COG0069	glutamate synthase activity
IF132_12805	COG0067	glutamate synthase
IF132_12805	COG0070	glutamate synthase
IF132_12810	COG0493	'glutamate synthase
IF132_12820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IF132_12825	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IF132_12830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IF132_12835	COG2860	membrane
IF132_12840	COG0583	DNA-binding transcription factor activity
IF132_12845	COG0730	response to heat
IF132_12850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IF132_12855	COG0505	Belongs to the CarA family
IF132_12865	COG0494	nUDIX hydrolase
IF132_12870	COG0653	protein targeting
IF132_12875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IF132_12880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IF132_12885	COG0849	cell division
IF132_12890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IF132_12905	COG0772	Belongs to the SEDS family
IF132_12915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IF132_12920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IF132_12930	COG0768	penicillin binding
IF132_12935	COG3116	cell division
IF132_12940	COG0275	rRNA processing
IF132_12950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IF132_12955	COG3107	peptidoglycan biosynthetic process
IF132_12960	COG0792	nuclease activity
IF132_12965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IF132_12975	COG2969	positive regulation of protein catabolic process
IF132_12980	COG0625	glutathione transferase activity
IF132_12985	COG2857	Cytochrome c1
IF132_12990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IF132_12995	COG0723	plastoquinol--plastocyanin reductase activity
IF132_13000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IF132_13005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IF132_13010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IF132_13015	COG3105	Protein conserved in bacteria
IF132_13020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IF132_13025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IF132_13040	COG3150	esterase
IF132_13050	COG3151	Protein conserved in bacteria
IF132_13055	COG0494	nUDIX hydrolase
IF132_13060	COG1538	Outer membrane efflux protein
IF132_13070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IF132_13085	COG3025	triphosphatase activity
IF132_13090	COG1392	Phosphate transport regulator
IF132_13095	COG0306	phosphate transporter
IF132_13100	COG4991	sh3 domain protein
IF132_13105	COG3267	Type II secretory pathway component ExeA
IF132_13105	COG3409	Peptidoglycan-binding domain 1 protein
IF132_13110	COG0617	tRNA 3'-terminal CCA addition
IF132_13115	COG1968	undecaprenyl-diphosphatase activity
IF132_13120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IF132_13125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IF132_13140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IF132_13145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IF132_13150	COG1610	YqeY-like protein
IF132_13155	COG0358	DNA primase activity
IF132_13175	COG3550	peptidyl-serine autophosphorylation
IF132_13200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF132_13200	COG2213	PTS system mannitol-specific
IF132_13210	COG3722	fumarate hydratase activity
IF132_13225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IF132_13255	COG2433	Pfam Transposase IS66
IF132_13275	COG3604	Transcriptional regulator
IF132_13285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IF132_13295	COG4208	sulfate ABC transporter
IF132_13305	COG0583	DNA-binding transcription factor activity
IF132_13310	COG2175	clavaminate synthase activity
IF132_13325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF132_13330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IF132_13335	COG0431	NADPH-dependent FMN reductase
IF132_13370	COG1349	DNA-binding transcription factor activity
IF132_13380	COG1802	Transcriptional regulator
IF132_13385	COG3706	GGDEF domain
IF132_13390	COG0440	acetolactate synthase activity
IF132_13395	COG0028	Belongs to the TPP enzyme family
IF132_13400	COG1022	Amp-dependent synthetase and ligase
IF132_13420	COG1309	transcriptional regulator
IF132_13425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IF132_13430	COG0473	3-isopropylmalate dehydrogenase activity
IF132_13440	COG0066	3-isopropylmalate dehydratase activity
IF132_13465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IF132_13470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IF132_13475	COG2967	ApaG domain
IF132_13490	COG3610	response to peptide
IF132_13495	COG2966	Psort location CytoplasmicMembrane, score
IF132_13500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IF132_13505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IF132_13510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IF132_13515	COG0142	geranyltranstransferase activity
IF132_13525	COG0039	L-malate dehydrogenase activity
IF132_13530	COG1438	arginine binding
IF132_13545	COG0589	response to stress
IF132_13550	COG3335	DDE superfamily endonuclease
IF132_13580	COG0175	sulfate reduction
IF132_13615	COG0735	belongs to the Fur family
IF132_13625	COG0166	Belongs to the GPI family
IF132_13640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IF132_13655	COG0359	binds to the 23S rRNA
IF132_13665	COG0360	Binds together with S18 to 16S ribosomal RNA
IF132_13670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IF132_13675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IF132_13685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IF132_13690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IF132_13720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IF132_13735	COG0165	Argininosuccinate lyase
IF132_13735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IF132_13740	COG0137	argininosuccinate synthase activity
IF132_13750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IF132_13755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IF132_13760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IF132_13770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IF132_13775	COG0527	aspartate kinase activity
IF132_13775	COG0460	homoserine dehydrogenase
IF132_13780	COG0626	cystathionine gamma-synthase activity
IF132_13785	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IF132_13790	COG0281	malic enzyme
IF132_13800	COG0254	rRNA binding
IF132_13805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IF132_13810	COG1609	Transcriptional regulator
IF132_13820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IF132_13825	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IF132_13830	COG1575	Belongs to the MenA family. Type 1 subfamily
IF132_13840	COG3074	FtsZ-dependent cytokinesis
IF132_13845	COG1494	fructose-1,6-bisphosphatase
IF132_13870	COG0149	triose-phosphate isomerase activity
IF132_13880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IF132_13890	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
IF132_13895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IF132_13915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IF132_13935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IF132_13945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IF132_13955	COG1215	transferase activity, transferring glycosyl groups
IF132_13960	COG5433	transposase activity
IF132_13975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IF132_13980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IF132_14000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IF132_14010	COG3206	protein involved in exopolysaccharide biosynthesis
IF132_14010	COG0489	protein tyrosine kinase activity
IF132_14025	COG1596	polysaccharide export
IF132_14045	COG0737	Belongs to the 5'-nucleotidase family
IF132_14070	COG1560	Kdo2-lipid A biosynthetic process
IF132_14075	COG0859	PFAM glycosyl transferase family 9
IF132_14080	COG1519	Transferase
IF132_14090	COG2089	acid synthase
IF132_14100	COG1083	cytidylyl-transferase
IF132_14105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IF132_14110	COG1086	Polysaccharide biosynthesis protein
IF132_14130	COG3642	lipopolysaccharide core region biosynthetic process
IF132_14135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IF132_14140	COG0859	PFAM glycosyl transferase family 9
IF132_14145	COG0463	Glycosyl transferase, family 2
IF132_14150	COG0859	PFAM glycosyl transferase family 9
IF132_14155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IF132_14170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IF132_14190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IF132_14195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IF132_14200	COG2003	Belongs to the UPF0758 family
IF132_14205	COG0840	transmembrane signaling receptor activity
IF132_14215	COG1309	transcriptional regulator
IF132_14220	COG1560	Kdo2-lipid A biosynthetic process
IF132_14230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IF132_14235	COG1561	YicC-like family, N-terminal region
IF132_14260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IF132_14270	COG1196	nuclear chromosome segregation
IF132_14365	COG4608	Belongs to the ABC transporter superfamily
IF132_14370	COG0444	Belongs to the ABC transporter superfamily
IF132_14375	COG0747	negative chemotaxis
IF132_14380	COG4239	(ABC) transporter, permease
IF132_14385	COG4174	ABC transporter (Permease)
IF132_14400	COG0811	peptide transport
IF132_14405	COG0811	peptide transport
IF132_14410	COG0848	biopolymer transport protein
IF132_14425	COG0194	GDP metabolic process
IF132_14430	COG1758	RNA polymerase activity
IF132_14435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IF132_14440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IF132_14445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IF132_14450	COG2233	PERMEase
IF132_14520	COG2183	response to ionizing radiation
IF132_14535	COG1040	competence protein
IF132_14540	COG0316	Belongs to the HesB IscA family
IF132_14540	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IF132_14545	COG0494	nUDIX hydrolase
IF132_14550	COG1218	3'(2'),5'-bisphosphate nucleotidase
IF132_14560	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IF132_14565	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IF132_14570	COG3156	type II secretion system protein K
IF132_14575	COG4795	General secretion pathway protein
IF132_14580	COG2165	general secretion pathway protein
IF132_14585	COG2165	general secretion pathway protein
IF132_14590	COG2165	general secretion pathway protein
IF132_14595	COG1459	type II secretion system
IF132_14600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF132_14610	COG3031	protein transport across the cell outer membrane
IF132_14615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IF132_14620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IF132_14635	COG0456	acetyltransferase
IF132_14640	COG1490	D-aminoacyl-tRNA deacylase activity
IF132_14645	COG1295	ribonuclease BN
IF132_14650	COG1217	gtp-binding protein TYPA
IF132_14655	COG0174	glutamine synthetase
IF132_14665	COG3852	Histidine kinase
IF132_14670	COG2204	response regulator
IF132_14675	COG2203	Gaf domain
IF132_14675	COG5001	Diguanylate cyclase
IF132_14675	COG3706	GGDEF domain
IF132_14675	COG4251	negative regulation of phosphorylation
IF132_14690	COG3078	GTPase activator activity
IF132_14715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF132_14715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF132_14730	COG0084	hydrolase, TatD family'
IF132_14735	COG0805	protein transport
IF132_14740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IF132_14750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IF132_14760	COG2226	methyltransferase
IF132_14765	COG1322	Protein conserved in bacteria
IF132_14785	COG2081	HI0933 family
IF132_14795	COG1528	Iron-storage protein
IF132_14800	COG0589	response to stress
IF132_14820	COG5001	Diguanylate cyclase
IF132_14820	COG5002	protein histidine kinase activity
IF132_14825	COG1522	sequence-specific DNA binding
IF132_14835	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IF132_14840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF132_14855	COG2814	Major facilitator Superfamily
IF132_14860	COG0800	Aldolase
IF132_14865	COG2610	gluconate transmembrane transporter activity
IF132_14870	COG3265	gluconokinase activity
IF132_14875	COG0129	dihydroxy-acid dehydratase activity
IF132_14880	COG1609	Transcriptional regulator
IF132_14915	COG2815	serine threonine protein kinase
IF132_14915	COG0515	serine threonine protein kinase
IF132_14950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF132_14955	COG0601	transmembrane transport
IF132_14960	COG4166	transmembrane transport
IF132_14965	COG4172	Belongs to the ABC transporter superfamily
IF132_15005	COG1309	transcriptional regulator
IF132_15010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF132_15015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF132_15020	COG2960	long-chain fatty acid transporting porin activity
IF132_15025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IF132_15030	COG0583	DNA-binding transcription factor activity
IF132_15035	COG3335	DDE superfamily endonuclease
IF132_15075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IF132_15085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IF132_15090	COG0408	coproporphyrinogen oxidase activity
IF132_15095	COG0009	L-threonylcarbamoyladenylate synthase
IF132_15100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IF132_15105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IF132_15110	COG0551	DNA topoisomerase type I activity
IF132_15115	COG2922	Belongs to the Smg family
IF132_15120	COG0758	DNA mediated transformation
IF132_15130	COG0242	peptide deformylase activity
IF132_15135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IF132_15140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IF132_15140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IF132_15145	COG0569	domain protein
IF132_15150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IF132_15160	COG1272	protein, Hemolysin III
IF132_15165	COG4326	sporulation control protein
IF132_15170	COG3084	Protein conserved in bacteria
IF132_15180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IF132_15185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF132_15190	COG0204	Acyl-transferase
IF132_15200	COG0606	chelatase, subunit chli
IF132_15210	COG3978	acetolactate synthase activity
IF132_15215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IF132_15230	COG0583	DNA-binding transcription factor activity
IF132_15235	COG2814	Major facilitator Superfamily
IF132_15245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IF132_15250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IF132_15255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IF132_15260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IF132_15265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IF132_15270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IF132_15280	COG0356	it plays a direct role in the translocation of protons across the membrane
IF132_15285	COG3312	ion transport
IF132_15290	COG1475	DNA binding
IF132_15295	COG1192	Involved in chromosome partitioning
IF132_15300	COG0357	Ribosomal RNA small subunit methyltransferase G
IF132_15305	COG0445	tRNA wobble uridine modification
IF132_15310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IF132_15320	COG0706	membrane insertase activity
IF132_15330	COG0594	ribonuclease P activity
IF132_15335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IF132_15340	COG1126	abc transporter atp-binding protein
IF132_15365	COG0592	DNA-directed DNA polymerase activity
IF132_15375	COG0187	DNA topoisomerase II activity
IF132_15380	COG0071	Belongs to the small heat shock protein (HSP20) family
IF132_15385	COG3977	Valine--pyruvate aminotransferase
IF132_15390	COG0751	glycine-tRNA ligase activity
IF132_15395	COG0752	glycyl-tRNA synthetase alpha subunit
IF132_15400	COG2119	membrane
IF132_15425	COG0655	NAD(P)H dehydrogenase (quinone) activity
IF132_15430	COG0583	DNA-binding transcription factor activity
IF132_15450	COG0604	alcohol dehydrogenase
IF132_15455	COG0183	Belongs to the thiolase family
IF132_15465	COG1739	Uncharacterized protein family UPF0029
IF132_15470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IF132_15475	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IF132_15510	COG3335	DDE superfamily endonuclease
IF132_15520	COG3335	DDE superfamily endonuclease
IF132_15525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IF132_15535	COG0352	thiamine-phosphate diphosphorylase activity
IF132_15540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IF132_15550	COG2022	thiamine diphosphate biosynthetic process
IF132_15555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IF132_15560	COG0006	proline dipeptidase activity
IF132_15560	COG0006	proline dipeptidase activity
IF132_15590	COG3220	belongs to the UPF0276 family
IF132_15600	COG0210	DNA helicase
IF132_15605	COG1280	lysine exporter protein (LysE YggA)
IF132_15615	COG2962	Rard protein
IF132_15620	COG0514	ATP-dependent DNA helicase (RecQ)
IF132_15630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IF132_15635	COG0248	Ppx GppA phosphatase
IF132_15645	COG3118	belongs to the thioredoxin family
IF132_15660	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IF132_15705	COG3335	DDE superfamily endonuclease
IF132_15720	COG3335	DDE superfamily endonuclease
IF132_15735	COG2959	enzyme of heme biosynthesis
IF132_15745	COG0181	hydroxymethylbilane synthase activity
IF132_15750	COG3072	Adenylate cyclase
IF132_15755	COG1965	Belongs to the frataxin family
IF132_15765	COG0019	diaminopimelate decarboxylase activity
IF132_15770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IF132_15780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IF132_15785	COG1011	Hydrolase
IF132_15790	COG2199	diguanylate cyclase activity
IF132_15790	COG2200	EAL domain
IF132_15790	COG3287	FIST C domain
IF132_15795	COG3148	PFAM DTW domain containing protein
IF132_15810	COG0561	phosphatase activity
IF132_15815	COG2267	carboxylic ester hydrolase activity
IF132_15820	COG1280	lysine exporter protein (LysE YggA)
IF132_15825	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IF132_15830	COG3274	enterobacterial common antigen metabolic process
IF132_15850	COG2095	MarC family integral membrane protein
IF132_15860	COG0742	ribosomal rna small subunit methyltransferase
IF132_15865	COG0552	protein localization to endoplasmic reticulum
IF132_15870	COG2884	Cell division ATP-binding protein ftsE
IF132_15875	COG2177	Part of the ABC transporter FtsEX involved in
IF132_15890	COG0705	Rhomboid family
IF132_15895	COG1580	Controls the rotational direction of flagella during chemotaxis
IF132_15905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IF132_15915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IF132_15925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF132_15945	COG1518	maintenance of DNA repeat elements
IF132_15950	COG1203	CRISPR-associated helicase, Cas3
IF132_15975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IF132_15990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IF132_15995	COG0724	RNA recognition motif
IF132_16105	COG3335	DDE superfamily endonuclease
IF132_16115	COG3335	DDE superfamily endonuclease
IF132_16120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF132_16130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IF132_16170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IF132_16185	COG0081	regulation of translation
IF132_16190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IF132_16195	COG0222	ribosome binding
IF132_16200	COG0085	RNA polymerase activity
IF132_16205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IF132_16220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IF132_16225	COG1573	uracil-dna glycosylase
IF132_16235	COG3068	Protein conserved in bacteria
IF132_16240	COG1253	flavin adenine dinucleotide binding
IF132_16260	COG0138	bifunctional purine biosynthesis protein purh
IF132_16270	COG0789	Transcriptional regulator
IF132_16275	COG0840	transmembrane signaling receptor activity
IF132_16300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IF132_16305	COG0732	type I restriction modification DNA specificity domain
IF132_16310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IF132_16315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IF132_16330	COG0439	Biotin carboxylase
IF132_16335	COG0511	ligase activity, forming carbon-carbon bonds
IF132_16340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IF132_16350	COG1902	pentaerythritol trinitrate reductase activity
IF132_16355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF132_16370	COG2814	Major facilitator Superfamily
IF132_16375	COG2198	Histidine kinase
IF132_16375	COG2205	protein histidine kinase activity
IF132_16375	COG0784	Response regulator, receiver
IF132_16400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IF132_16425	COG4232	protein-disulfide reductase activity
IF132_16430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IF132_16435	COG1027	Aspartate ammonia-lyase
IF132_16440	COG3030	protein affecting phage T7 exclusion by the F plasmid
IF132_16445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IF132_16450	COG2205	protein histidine kinase activity
IF132_16455	COG0745	RESPONSE REGULATOR receiver
IF132_16470	COG0205	6-phosphofructokinase activity
IF132_16475	COG0534	Mate efflux family protein
IF132_16480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IF132_16485	COG0459	protein refolding
IF132_16500	COG1509	lysine 2,3-aminomutase activity
IF132_16505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IF132_16520	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IF132_16525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IF132_16530	COG1053	succinate dehydrogenase
IF132_16535	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IF132_16555	COG4942	peptidase
IF132_16560	COG1045	serine acetyltransferase
IF132_16565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IF132_16570	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IF132_16575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF132_16590	COG0471	metal ion transport
IF132_16595	COG0688	phosphatidylethanolamine metabolic process
IF132_16600	COG1162	GTPase activity
IF132_16605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IF132_16685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IF132_16690	COG0802	atpase or kinase
IF132_16695	COG0860	N-Acetylmuramoyl-L-alanine amidase
IF132_16700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IF132_16715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IF132_16720	COG0330	HflC and HflK could
IF132_16725	COG0330	HflC and HflK could
IF132_16730	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IF132_16735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IF132_16740	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IF132_16745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF132_16745	COG1017	nitric oxide dioxygenase activity
IF132_16750	COG1959	2 iron, 2 sulfur cluster binding
IF132_16755	COG0557	exoribonuclease II activity
IF132_16760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IF132_16770	COG0180	Tryptophanyl-tRNA synthetase
IF132_16790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IF132_16800	COG1012	belongs to the aldehyde dehydrogenase family
IF132_16810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF132_16815	COG3954	Phosphoribulokinase
IF132_16820	COG3089	Belongs to the UPF0270 family
IF132_16825	COG0429	hydrolase of the alpha beta-hydrolase fold
IF132_16835	COG0488	(ABC) transporter
IF132_16840	COG2249	NAD(P)H dehydrogenase (quinone) activity
IF132_16855	COG1047	Peptidyl-prolyl cis-trans
IF132_16860	COG1446	asparaginase
IF132_16865	COG2900	Belongs to the SlyX family
IF132_16875	COG0545	Peptidyl-prolyl cis-trans isomerase
IF132_16880	COG2964	Protein conserved in bacteria
IF132_16885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IF132_16890	COG2923	Belongs to the DsrF TusC family
IF132_16900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IF132_16905	COG0049	tRNA binding
IF132_16910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IF132_16920	COG2906	2 iron, 2 sulfur cluster binding
IF132_16935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IF132_16940	COG0088	Forms part of the polypeptide exit tunnel
IF132_16950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IF132_16955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IF132_16960	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IF132_16965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IF132_16970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IF132_16980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IF132_16985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IF132_16990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IF132_16995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IF132_17000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IF132_17005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IF132_17010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IF132_17015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IF132_17020	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IF132_17025	COG1841	ribosomal large subunit assembly
IF132_17030	COG0200	Binds to the 23S rRNA
IF132_17035	COG0201	protein transport
IF132_17040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IF132_17045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IF132_17050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IF132_17060	COG0202	RNA polymerase activity
IF132_17065	COG0203	ribosomal protein L17
IF132_17070	COG0545	Peptidyl-prolyl cis-trans isomerase
IF132_17080	COG0697	spore germination
IF132_17085	COG2153	protein acetylation
IF132_17095	COG0737	Belongs to the 5'-nucleotidase family
IF132_17100	COG1648	precorrin-2 dehydrogenase activity
IF132_17100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IF132_17110	COG2895	sulfate adenylyltransferase (ATP) activity
IF132_17115	COG0471	metal ion transport
IF132_17115	COG3273	potassium ion transport
IF132_17120	COG0529	Catalyzes the synthesis of activated sulfate
IF132_17140	COG1136	(ABC) transporter
IF132_17140	COG0577	efflux transmembrane transporter activity
IF132_17155	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IF132_17170	COG0729	surface antigen
IF132_17175	COG2911	Protein conserved in bacteria
IF132_17180	COG2105	PFAM AIG2 family protein
IF132_17185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IF132_17190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IF132_17195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IF132_17200	COG0163	prenyltransferase activity
IF132_17210	COG1178	ABC-type Fe3 transport system permease component
IF132_17215	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IF132_17220	COG3028	Belongs to the UPF0307 family
IF132_17225	COG0312	modulator of DNA gyrase
IF132_17230	COG2239	Acts as a magnesium transporter
IF132_17235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF132_17240	COG1660	Displays ATPase and GTPase activities
IF132_17245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF132_17250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IF132_17260	COG1137	ATPase activity
IF132_17275	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IF132_17280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IF132_17280	COG0517	IMP dehydrogenase activity
IF132_17290	COG1127	ABC transporter
IF132_17295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IF132_17300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IF132_17305	COG2854	intermembrane phospholipid transfer
IF132_17315	COG5007	Belongs to the BolA IbaG family
IF132_17320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IF132_17325	COG0204	Acyl-transferase
IF132_17335	COG1410	methionine synthase
IF132_17335	COG0646	methionine synthase
IF132_17340	COG0527	aspartate kinase activity
IF132_17345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IF132_17355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IF132_17370	COG5433	transposase activity
IF132_17430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IF132_17455	COG3550	peptidyl-serine autophosphorylation
IF132_17490	COG2200	EAL domain
IF132_17490	COG2199	diguanylate cyclase activity
IF132_17515	COG3409	Peptidoglycan-binding domain 1 protein
IF132_17515	COG3267	Type II secretory pathway component ExeA
IF132_17525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF132_17530	COG1459	type II secretion system
IF132_17545	COG2165	general secretion pathway protein
IF132_17575	COG1077	Cell shape determining protein MreB Mrl
IF132_17580	COG1792	Involved in formation and maintenance of cell shape
IF132_17585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IF132_17590	COG0424	maF-like protein
IF132_17600	COG3164	Protein of unknown function
IF132_17605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IF132_17610	COG0312	modulator of DNA gyrase
IF132_17615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IF132_17630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF132_17635	COG0251	oxidation-reduction process
IF132_17640	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IF132_17670	COG0456	acetyltransferase
IF132_17680	COG4269	membrane
IF132_17690	COG0525	valine-tRNA ligase activity
IF132_17695	COG2927	DNA polymerase III (CHI subunit)
IF132_17700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IF132_17705	COG0795	lipopolysaccharide-transporting ATPase activity
IF132_17710	COG0795	lipopolysaccharide-transporting ATPase activity
IF132_17810	COG0840	transmembrane signaling receptor activity
IF132_17830	COG0741	lytic transglycosylase activity
IF132_17835	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IF132_17840	COG1194	a g-specific adenine glycosylase
IF132_17845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IF132_17850	COG2066	Belongs to the glutaminase family
IF132_17855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IF132_17860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IF132_17875	COG0762	integral membrane protein
IF132_17880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IF132_17885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IF132_17900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IF132_17905	COG1678	Uncharacterized ACR, COG1678
IF132_17915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IF132_17920	COG2356	endonuclease I
IF132_17930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IF132_17935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IF132_17940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF132_17945	COG0126	phosphoglycerate kinase activity
IF132_17950	COG0191	fructose-bisphosphate aldolase activity
IF132_17955	COG0668	transmembrane transport
IF132_17975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF132_17985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IF132_17995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IF132_18000	COG3079	Belongs to the UPF0149 family
IF132_18005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF132_18010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF132_18025	COG0354	folic acid binding
IF132_18040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IF132_18045	COG1595	DNA-templated transcription, initiation
IF132_18055	COG3026	antisigma factor binding
IF132_18060	COG3086	response to oxidative stress
IF132_18065	COG0481	GTPase activity
IF132_18070	COG0681	Belongs to the peptidase S26 family
IF132_18080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IF132_18090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IF132_18110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IF132_18115	COG3956	TIGRFAM MazG family protein
IF132_18120	COG0504	CTP synthase activity
IF132_18125	COG0148	phosphopyruvate hydratase activity
IF132_18130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IF132_18135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IF132_18155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IF132_18170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IF132_18175	COG1546	Belongs to the CinA family
IF132_18180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IF132_18190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IF132_18195	COG0527	aspartate kinase activity
IF132_18245	COG3630	sodium ion export across plasma membrane
IF132_18250	COG5016	pyruvate
IF132_18250	COG0511	ligase activity, forming carbon-carbon bonds
IF132_18255	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IF132_18260	COG1063	alcohol dehydrogenase
IF132_18265	COG1238	metal cluster binding
IF132_18270	COG0612	Peptidase, M16
IF132_18285	COG1854	S-ribosylhomocysteine lyase activity
IF132_18290	COG4536	flavin adenine dinucleotide binding
IF132_18295	COG4137	Cytochrome C assembly protein
IF132_18300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IF132_18305	COG0228	four-way junction DNA binding
IF132_18310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IF132_18315	COG0336	Belongs to the RNA methyltransferase TrmD family
IF132_18320	COG0335	large ribosomal subunit rRNA binding
IF132_18325	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IF132_18335	COG0237	dephospho-CoA kinase activity
IF132_18350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF132_18355	COG4969	Belongs to the N-Me-Phe pilin family
IF132_18375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IF132_18380	COG0508	dehydrogenase complex catalyzes the overall conversion of
IF132_18385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF132_18400	COG0288	reversible hydration of carbon dioxide
IF132_18405	COG0659	secondary active sulfate transmembrane transporter activity
IF132_18410	COG1131	(ABC) transporter
IF132_18415	COG0842	Transport permease protein
IF132_18425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IF132_18430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IF132_18440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF132_18445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IF132_18455	COG1643	Atp-dependent helicase
IF132_18460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IF132_18465	COG1752	Esterase of the alpha-beta hydrolase superfamily
IF132_18470	COG1049	propionate catabolic process, 2-methylcitrate cycle
IF132_18475	COG1929	Belongs to the glycerate kinase type-1 family
IF132_18480	COG3112	Uncharacterised protein family (UPF0231)
IF132_18515	COG1121	(ABC) transporter
IF132_18520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IF132_18530	COG0745	RESPONSE REGULATOR receiver
IF132_18540	COG4771	TonB-dependent receptor
IF132_18545	COG0347	Belongs to the P(II) protein family
IF132_18550	COG0004	ammonium transporteR
IF132_18555	COG1840	ABC-type Fe3 transport system, periplasmic component
IF132_18565	COG3842	ATPase activity
IF132_18570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF132_18585	COG2971	BadF BadG BcrA BcrD
IF132_18595	COG4608	Belongs to the ABC transporter superfamily
IF132_18600	COG0444	Belongs to the ABC transporter superfamily
IF132_18605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF132_18610	COG0601	transmembrane transport
IF132_18615	COG0747	negative chemotaxis
IF132_18620	COG0784	Response regulator, receiver
IF132_18620	COG2205	protein histidine kinase activity
IF132_18625	COG2813	Specifically methylates the guanine in position
IF132_18630	COG0628	permease
IF132_18635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IF132_18655	COG0739	heme binding
IF132_18660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IF132_18665	COG2027	D-alanyl-D-alanine carboxypeptidase
IF132_18670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IF132_18675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF132_18680	COG1534	Rna-binding protein
IF132_18685	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IF132_18690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IF132_18695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IF132_18700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF132_18705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IF132_18720	COG0779	Required for maturation of 30S ribosomal subunits
IF132_18725	COG0195	Participates in both transcription termination and antitermination
IF132_18735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IF132_18740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IF132_18745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IF132_18750	COG1185	polyribonucleotide nucleotidyltransferase activity
IF132_18765	COG0534	Mate efflux family protein
IF132_18770	COG0826	peptidase U32
IF132_18775	COG0826	peptidase U32
IF132_18785	COG3154	lipid carrier protein
IF132_18790	COG3153	acetyltransferase
IF132_18820	COG0084	hydrolase, TatD family'
IF132_18825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IF132_18830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IF132_18835	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IF132_18840	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IF132_18845	COG0813	purine-nucleoside phosphorylase activity
IF132_18855	COG0560	Phosphoserine phosphatase
IF132_18865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IF132_18870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IF132_18875	COG0583	DNA-binding transcription factor activity
IF132_18890	COG2059	Chromate
IF132_18895	COG0583	DNA-binding transcription factor activity
IF132_18920	COG0456	acetyltransferase
IF132_18930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IF132_18935	COG1349	DNA-binding transcription factor activity
IF132_18940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IF132_18945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IF132_18950	COG2171	N-acyltransferase activity
IF132_18955	COG3141	response to X-ray
IF132_18970	COG3083	sulfuric ester hydrolase activity
IF132_18975	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IF132_18980	COG1074	ATP-dependent DNA helicase activity
IF132_18985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IF132_19005	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IF132_19010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IF132_19015	COG2166	iron-sulfur cluster assembly
IF132_19020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IF132_19030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IF132_19045	COG1595	DNA-templated transcription, initiation
IF132_19070	COG2813	Specifically methylates the guanine in position
IF132_19075	COG0271	Belongs to the BolA IbaG family
IF132_19080	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IF132_19085	COG1805	sodium ion transport
IF132_19095	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IF132_19100	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IF132_19105	COG2871	sodium ion transport
IF132_19110	COG1477	protein flavinylation
IF132_19125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IF132_19130	COG0514	ATP-dependent DNA helicase (RecQ)
IF132_19140	COG0733	neurotransmitter:sodium symporter activity
IF132_19165	COG1720	tRNA m6t6A37 methyltransferase activity
IF132_19170	COG0254	rRNA binding
IF132_19175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IF132_19180	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IF132_19210	COG3098	single-species biofilm formation
IF132_19225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IF132_19230	COG0024	Methionine aminopeptidase
IF132_19235	COG0052	Belongs to the universal ribosomal protein uS2 family
IF132_19240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IF132_19250	COG0233	cytoplasmic translational termination
IF132_19255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IF132_19260	COG0575	Belongs to the CDS family
IF132_19270	COG0750	zinc metalloprotease
IF132_19280	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IF132_19285	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF132_19290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF132_19295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF132_19300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF132_19310	COG0587	DNA-directed DNA polymerase activity
IF132_19315	COG0825	malonyl-CoA metabolic process
IF132_19330	COG0347	Belongs to the P(II) protein family
IF132_19335	COG3021	interspecies interaction between organisms
IF132_19345	COG0741	lytic transglycosylase activity
IF132_19345	COG1388	LysM domain
IF132_19350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IF132_19355	COG2226	methyltransferase
IF132_19360	COG0328	RNA-DNA hybrid ribonuclease activity
IF132_19375	COG1960	acyl-CoA dehydrogenase activity
IF132_19385	COG0121	glutamine amidotransferase
IF132_19390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IF132_19395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IF132_19400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IF132_19405	COG2233	PERMEase
IF132_19425	COG1393	Belongs to the ArsC family
IF132_19445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IF132_19450	COG2716	regulation of RNA biosynthetic process
IF132_19455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IF132_19460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IF132_19480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IF132_19515	COG2837	iron assimilation
IF132_19520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF132_19525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF132_19530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF132_19535	COG1334	flagellar protein FlaG
IF132_19540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IF132_19550	COG1516	flagellar protein fliS
IF132_19570	COG1677	Flagellar hook-basal body complex protein FliE
IF132_19580	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IF132_19630	COG1987	bacterial-type flagellum assembly
IF132_19635	COG1684	flagellar biosynthetic protein fliR
IF132_19670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IF132_19675	COG0643	Histidine kinase
IF132_19675	COG0784	Response regulator, receiver
IF132_19675	COG2198	Histidine kinase
IF132_19680	COG2201	protein-glutamate methylesterase activity
IF132_19685	COG1192	Involved in chromosome partitioning
IF132_19695	COG0835	chemotaxis
IF132_19705	COG4133	protoheme IX ABC transporter activity
IF132_19710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IF132_19715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IF132_19720	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IF132_19725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IF132_19730	COG1138	Cytochrome C-type biogenesis protein
IF132_19735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IF132_19750	COG2853	Lipoprotein
IF132_19760	COG2067	long-chain fatty acid transport protein
IF132_19770	COG1595	DNA-templated transcription, initiation
IF132_19775	COG0183	Belongs to the thiolase family
IF132_19780	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF132_19780	COG1024	Enoyl-CoA hydratase
IF132_19785	COG1025	Belongs to the peptidase M16 family
IF132_19790	COG2062	phosphohistidine phosphatase, SixA
IF132_19795	COG2840	Smr protein MutS2
IF132_19800	COG2890	protein-(glutamine-N5) methyltransferase activity
IF132_19805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IF132_19815	COG0583	DNA-binding transcription factor activity
IF132_19825	COG2860	membrane
IF132_19830	COG3101	peptidyl-lysine hydroxylation
IF132_19850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IF132_19860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IF132_19870	COG0101	tRNA pseudouridine synthase activity
IF132_19875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IF132_19880	COG0285	dihydrofolate synthase activity
IF132_19885	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IF132_19890	COG1286	toxin biosynthetic process
IF132_19895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IF132_19900	COG0583	DNA-binding transcription factor activity
IF132_19905	COG0745	RESPONSE REGULATOR receiver
IF132_19910	COG2832	Protein of unknown function (DUF454)
IF132_19915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IF132_19925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IF132_19930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IF132_19945	COG2205	protein histidine kinase activity
IF132_19950	COG0745	RESPONSE REGULATOR receiver
IF132_19960	COG2983	Belongs to the UPF0260 family
IF132_19965	COG1785	Belongs to the alkaline phosphatase family
IF132_19980	COG2226	methyltransferase
IF132_19985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IF132_20010	COG2239	Acts as a magnesium transporter
IF132_20015	COG1285	pathogenesis
IF132_20020	COG2873	o-acetylhomoserine
IF132_20030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IF132_20050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF132_20065	COG3139	Protein of unknown function (DUF1315)
IF132_20070	COG0252	asparaginase activity
IF132_20075	COG0616	signal peptide processing
IF132_20080	COG0446	pyridine nucleotide-disulphide oxidoreductase
IF132_20080	COG1902	pentaerythritol trinitrate reductase activity
IF132_20085	COG0778	Nitroreductase
IF132_20090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IF132_20095	COG0123	including yeast histone deacetylase and acetoin utilization protein
IF132_20105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF132_20110	COG3083	sulfuric ester hydrolase activity
IF132_20120	COG3081	Nucleoid-associated protein
IF132_20130	COG1757	Na H antiporter
IF132_20135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IF132_20145	COG2095	MarC family integral membrane protein
IF132_20150	COG1454	alcohol dehydrogenase
IF132_20150	COG1012	belongs to the aldehyde dehydrogenase family
IF132_20155	COG1028	Short-chain dehydrogenase reductase Sdr
IF132_20170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IF132_20180	COG2056	Na+-H+ antiporter family
IF132_20185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IF132_20190	COG2885	chlorophyll binding
IF132_20200	COG0346	lactoylglutathione lyase activity
IF132_20205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IF132_20210	COG4660	Part of a membrane complex involved in electron transport
IF132_20215	COG4659	FMN binding
IF132_20220	COG4658	electron transport chain
IF132_20225	COG4656	Part of a membrane complex involved in electron transport
IF132_20230	COG2878	Part of a membrane complex involved in electron transport
IF132_20235	COG4657	Part of a membrane complex involved in electron transport
IF132_20245	COG1566	PFAM secretion protein HlyD family protein
IF132_20250	COG2814	Major facilitator Superfamily
IF132_20260	COG0556	nucleotide-excision repair
IF132_20265	COG2204	response regulator
IF132_20270	COG2198	Histidine kinase
IF132_20275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IF132_20280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IF132_20285	COG0521	Mo-molybdopterin cofactor biosynthetic process
IF132_20290	COG0315	cyclic pyranopterin monophosphate synthase activity
IF132_20295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IF132_20300	COG0314	molybdopterin synthase activity
IF132_20310	COG0601	transmembrane transport
IF132_20315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF132_20320	COG0444	Belongs to the ABC transporter superfamily
IF132_20330	COG0435	Glutathione S-transferase
IF132_20335	COG3174	membrane
IF132_20340	COG0857	belongs to the CobB CobQ family
IF132_20340	COG0280	phosphate acetyltransferase
IF132_20345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IF132_20350	COG3092	negative regulation of chromosome organization
IF132_20360	COG4120	Belongs to the binding-protein-dependent transport system permease family
IF132_20370	COG0366	Alpha amylase catalytic
IF132_20380	COG0653	protein targeting
IF132_20390	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF132_20395	COG2186	Transcriptional regulator
IF132_20405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF132_20405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF132_20410	COG0489	protein tyrosine kinase activity
IF132_20415	COG0572	uridine kinase
IF132_20425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IF132_20430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IF132_20435	COG1530	ribonuclease E activity
IF132_20445	COG0424	maF-like protein
IF132_20450	COG1399	metal-binding, possibly nucleic acid-binding protein
IF132_20455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IF132_20460	COG0416	fatty acid biosynthetic process
IF132_20465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IF132_20480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF132_20495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IF132_20500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IF132_20510	COG0084	hydrolase, TatD family'
IF132_20515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF132_20515	COG1263	PTS System
IF132_20525	COG0733	neurotransmitter:sodium symporter activity
IF132_20540	COG4667	esterase of the alpha-beta hydrolase superfamily
IF132_20545	COG0469	pyruvate kinase activity
IF132_20550	COG1940	carbohydrate kinase activity
IF132_20555	COG0784	Response regulator, receiver
IF132_20555	COG0835	chemotaxis
IF132_20560	COG0587	DNA-directed DNA polymerase activity
IF132_20575	COG1028	Short-chain dehydrogenase reductase Sdr
IF132_20580	COG0616	signal peptide processing
IF132_20590	COG0539	negative regulation of cytoplasmic translation
IF132_20600	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IF132_20605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IF132_20615	COG0601	transmembrane transport
IF132_20620	COG4239	(ABC) transporter, permease
IF132_20625	COG4166	transmembrane transport
IF132_20630	COG0444	Belongs to the ABC transporter superfamily
IF132_20635	COG4608	Belongs to the ABC transporter superfamily
IF132_20670	COG0583	DNA-binding transcription factor activity
IF132_20680	COG0686	Belongs to the AlaDH PNT family
IF132_20685	COG1522	sequence-specific DNA binding
IF132_20695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IF132_20700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IF132_20715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IF132_20720	COG0156	8-amino-7-oxononanoate synthase activity
IF132_20725	COG2226	methyltransferase
IF132_20730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IF132_20740	COG0501	Belongs to the peptidase M48B family
IF132_20750	COG1028	Short-chain dehydrogenase reductase Sdr
IF132_20765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IF132_20775	COG2268	Band 7 protein
IF132_20785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IF132_20790	COG2915	High frequency lysogenization protein hflD homolog
IF132_20795	COG0482	sulfurtransferase activity
IF132_20805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF132_20815	COG1757	Na H antiporter
IF132_20820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IF132_20825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IF132_20830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IF132_20835	COG0131	Imidazoleglycerol-phosphate dehydratase
IF132_20835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IF132_20840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IF132_20845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IF132_20855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IF132_20855	COG0140	phosphoribosyl-ATP diphosphatase activity
IF132_20860	COG3012	SEC-C Motif Domain Protein
IF132_20865	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IF132_20870	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF132_20875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IF132_20880	COG0215	cysteine-tRNA ligase activity
IF132_20885	COG1435	thymidine kinase activity
IF132_20890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF132_20910	COG2116	formate transmembrane transporter activity
IF132_20915	COG4459	periplasmic nitrate reductase
IF132_20920	COG3005	denitrification pathway
IF132_20940	COG1227	inorganic diphosphatase activity
IF132_20955	COG4172	Belongs to the ABC transporter superfamily
IF132_20980	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IF132_20985	COG1842	Phage shock protein A
IF132_20995	COG1983	PspC domain protein
IF132_21015	COG3068	Protein conserved in bacteria
IF132_21020	COG0668	transmembrane transport
IF132_21030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF132_21045	COG2818	Glycosylase
IF132_21050	COG0626	cystathionine gamma-synthase activity
IF132_21060	COG0733	neurotransmitter:sodium symporter activity
IF132_21065	COG0564	pseudouridine synthase activity
IF132_21070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF132_21070	COG0116	Belongs to the methyltransferase superfamily
IF132_21075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF132_21080	COG1151	hydroxylamine reductase activity
IF132_21085	COG3604	Transcriptional regulator
IF132_21090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IF132_21095	COG4136	ATPase activity
IF132_21100	COG4135	transport system, permease component
IF132_21105	COG4134	Bacterial extracellular solute-binding protein
IF132_21115	COG3313	Fe-S protein
IF132_21125	COG0737	Belongs to the 5'-nucleotidase family
IF132_21130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IF132_21135	COG5002	protein histidine kinase activity
IF132_21150	COG1061	Type III restriction enzyme res subunit
IF132_21160	COG2814	Major facilitator Superfamily
IF132_21170	COG0702	epimerase
IF132_21175	COG0534	Mate efflux family protein
IF132_21195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF132_21215	COG2985	domain, Protein
IF132_21215	COG3273	potassium ion transport
IF132_21220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IF132_21225	COG1012	belongs to the aldehyde dehydrogenase family
IF132_21225	COG1454	alcohol dehydrogenase
IF132_21230	COG1737	Transcriptional regulator
IF132_21235	COG0076	glutamate decarboxylase activity
IF132_21245	COG2431	L-lysine efflux transmembrane transporter activity
IF132_21255	COG3070	regulator of competence-specific genes
IF132_21270	COG5002	protein histidine kinase activity
IF132_21270	COG5002	protein histidine kinase activity
IF132_21280	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IF132_21285	COG1132	(ABC) transporter
IF132_21290	COG4774	siderophore transport
IF132_21295	COG1120	ATPase activity
IF132_21300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IF132_21310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IF132_21315	COG4988	ABC transporter
IF132_21320	COG0492	ferredoxin-NADP+ reductase activity
IF132_21330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IF132_21345	COG0471	metal ion transport
IF132_21350	COG2949	membrane
IF132_21355	COG0281	malic enzyme
IF132_21360	COG1643	Atp-dependent helicase
IF132_21370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IF132_21390	COG2885	chlorophyll binding
IF132_21425	COG2986	histidine ammonia-lyase
IF132_21430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IF132_21435	COG0010	Belongs to the arginase family
IF132_21485	COG0110	maltose O-acetyltransferase activity
IF132_21490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IF132_21495	COG1280	lysine exporter protein (LysE YggA)
IF132_21500	COG1115	amino acid carrier protein
IF132_21525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF132_21540	COG3290	protein histidine kinase activity
IF132_21545	COG4565	transcriptional regulatory protein
IF132_21550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IF132_21555	COG0363	glucosamine-6-phosphate deaminase activity
IF132_21560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IF132_21575	COG2433	Pfam Transposase IS66
IF132_21595	COG2026	Addiction module toxin, RelE StbE family
IF132_21630	COG4977	sequence-specific DNA binding
IF132_21640	COG2026	Addiction module toxin, RelE StbE family
IF132_21685	COG4628	conserved protein (DUF2132)