locus-tag	class	description
D3H41_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3H41_00010	COG0592	DNA-directed DNA polymerase activity
D3H41_00020	COG0187	DNA topoisomerase II activity
D3H41_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
D3H41_00040	COG3977	Valine--pyruvate aminotransferase
D3H41_00045	COG0366	Alpha amylase catalytic
D3H41_00060	COG2119	membrane
D3H41_00070	COG0425	Belongs to the sulfur carrier protein TusA family
D3H41_00085	COG0604	alcohol dehydrogenase
D3H41_00090	COG0183	Belongs to the thiolase family
D3H41_00100	COG1739	Uncharacterized protein family UPF0029
D3H41_00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_00145	COG0583	DNA-binding transcription factor activity
D3H41_00150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3H41_00155	COG2960	long-chain fatty acid transporting porin activity
D3H41_00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_00220	COG4172	Belongs to the ABC transporter superfamily
D3H41_00225	COG4166	transmembrane transport
D3H41_00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_00275	COG1609	Transcriptional regulator
D3H41_00280	COG0583	DNA-binding transcription factor activity
D3H41_00290	COG2076	Multidrug Resistance protein
D3H41_00295	COG0129	dihydroxy-acid dehydratase activity
D3H41_00300	COG3265	gluconokinase activity
D3H41_00305	COG2610	gluconate transmembrane transporter activity
D3H41_00310	COG0800	Aldolase
D3H41_00315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3H41_00320	COG0583	DNA-binding transcription factor activity
D3H41_00325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_00330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3H41_00340	COG1522	sequence-specific DNA binding
D3H41_00345	COG5002	protein histidine kinase activity
D3H41_00345	COG5001	Diguanylate cyclase
D3H41_00350	COG0742	ribosomal rna small subunit methyltransferase
D3H41_00360	COG0697	spore germination
D3H41_00365	COG0589	response to stress
D3H41_00370	COG1528	Iron-storage protein
D3H41_00380	COG2081	HI0933 family
D3H41_00410	COG1597	lipid kinase activity
D3H41_00440	COG0628	permease
D3H41_00455	COG1322	Protein conserved in bacteria
D3H41_00460	COG2226	methyltransferase
D3H41_00465	COG3165	ubiquinone biosynthetic process from chorismate
D3H41_00470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3H41_00485	COG0805	protein transport
D3H41_00495	COG0084	hydrolase, TatD family'
D3H41_00510	COG0456	acetyltransferase
D3H41_00520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H41_00520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H41_00525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3H41_00555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3H41_00560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3H41_00570	COG2204	response regulator
D3H41_00575	COG3852	Histidine kinase
D3H41_00585	COG0174	glutamine synthetase
D3H41_00595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3H41_00605	COG1295	ribonuclease BN
D3H41_00610	COG1490	D-aminoacyl-tRNA deacylase activity
D3H41_00615	COG0456	acetyltransferase
D3H41_00625	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D3H41_00630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D3H41_00635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3H41_00640	COG3031	protein transport across the cell outer membrane
D3H41_00650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3H41_00655	COG1459	type II secretion system
D3H41_00660	COG2165	general secretion pathway protein
D3H41_00665	COG2165	general secretion pathway protein
D3H41_00670	COG2165	general secretion pathway protein
D3H41_00675	COG4795	General secretion pathway protein
D3H41_00680	COG3156	type II secretion system protein K
D3H41_00685	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D3H41_00690	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D3H41_00700	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3H41_00705	COG0494	nUDIX hydrolase
D3H41_00715	COG1040	competence protein
D3H41_00730	COG2183	response to ionizing radiation
D3H41_00740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_00750	COG0745	RESPONSE REGULATOR receiver
D3H41_00755	COG2205	protein histidine kinase activity
D3H41_00760	COG2233	PERMEase
D3H41_00765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3H41_00770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H41_00775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3H41_00780	COG1758	RNA polymerase activity
D3H41_00785	COG0194	GDP metabolic process
D3H41_00805	COG0848	biopolymer transport protein
D3H41_00810	COG0811	peptide transport
D3H41_00835	COG4174	ABC transporter (Permease)
D3H41_00840	COG4239	(ABC) transporter, permease
D3H41_00845	COG0747	negative chemotaxis
D3H41_00850	COG0444	Belongs to the ABC transporter superfamily
D3H41_00855	COG4608	Belongs to the ABC transporter superfamily
D3H41_00865	COG5001	Diguanylate cyclase
D3H41_00900	COG1561	YicC-like family, N-terminal region
D3H41_00910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3H41_00920	COG1560	Kdo2-lipid A biosynthetic process
D3H41_00925	COG1309	transcriptional regulator
D3H41_00930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3H41_00940	COG0840	transmembrane signaling receptor activity
D3H41_00945	COG2003	Belongs to the UPF0758 family
D3H41_00970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3H41_00985	COG0463	Glycosyl transferase, family 2
D3H41_00990	COG0859	PFAM glycosyl transferase family 9
D3H41_00995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D3H41_01000	COG3642	lipopolysaccharide core region biosynthetic process
D3H41_01030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_01040	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_01045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3H41_01060	COG1519	Transferase
D3H41_01065	COG0859	PFAM glycosyl transferase family 9
D3H41_01075	COG1560	Kdo2-lipid A biosynthetic process
D3H41_01085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_01125	COG2089	acid synthase
D3H41_01140	COG2244	polysaccharide biosynthetic process
D3H41_01155	COG1215	transferase activity, transferring glycosyl groups
D3H41_01165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H41_01185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3H41_01190	COG0149	triose-phosphate isomerase activity
D3H41_01220	COG1494	fructose-1,6-bisphosphatase
D3H41_01230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3H41_01235	COG1575	Belongs to the MenA family. Type 1 subfamily
D3H41_01240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3H41_01245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D3H41_01255	COG1609	Transcriptional regulator
D3H41_01260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3H41_01270	COG0254	rRNA binding
D3H41_01280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3H41_01285	COG0088	Forms part of the polypeptide exit tunnel
D3H41_01295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3H41_01300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3H41_01305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3H41_01310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3H41_01320	COG0255	Belongs to the universal ribosomal protein uL29 family
D3H41_01325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3H41_01335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3H41_01340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D3H41_01350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3H41_01355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3H41_01370	COG1841	ribosomal large subunit assembly
D3H41_01380	COG0201	protein transport
D3H41_01390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3H41_01395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3H41_01405	COG0202	RNA polymerase activity
D3H41_01410	COG0203	ribosomal protein L17
D3H41_01420	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H41_01430	COG2153	protein acetylation
D3H41_01435	COG0513	Belongs to the DEAD box helicase family
D3H41_01450	COG1648	precorrin-2 dehydrogenase activity
D3H41_01450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3H41_01455	COG0175	sulfate reduction
D3H41_01460	COG2895	sulfate adenylyltransferase (ATP) activity
D3H41_01465	COG3273	potassium ion transport
D3H41_01465	COG0471	metal ion transport
D3H41_01470	COG0529	Catalyzes the synthesis of activated sulfate
D3H41_01490	COG4181	ATPase activity
D3H41_01505	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D3H41_01515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_01520	COG0729	surface antigen
D3H41_01525	COG2911	Protein conserved in bacteria
D3H41_01530	COG2105	PFAM AIG2 family protein
D3H41_01540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3H41_01545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D3H41_01555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3H41_01560	COG0163	prenyltransferase activity
D3H41_01565	COG4143	(ABC) transporter
D3H41_01570	COG1178	ABC-type Fe3 transport system permease component
D3H41_01575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D3H41_01580	COG0583	DNA-binding transcription factor activity
D3H41_01585	COG1902	pentaerythritol trinitrate reductase activity
D3H41_01630	COG0142	geranyltranstransferase activity
D3H41_01635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3H41_01645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3H41_01650	COG2966	Psort location CytoplasmicMembrane, score
D3H41_01665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3H41_01670	COG2967	ApaG domain
D3H41_01675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3H41_01680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3H41_01685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H41_01690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3H41_01695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3H41_01715	COG0473	3-isopropylmalate dehydrogenase activity
D3H41_01720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3H41_01745	COG0583	DNA-binding transcription factor activity
D3H41_01750	COG1022	Amp-dependent synthetase and ligase
D3H41_01755	COG0028	Belongs to the TPP enzyme family
D3H41_01760	COG0440	acetolactate synthase activity
D3H41_01765	COG3706	GGDEF domain
D3H41_01775	COG0469	pyruvate kinase activity
D3H41_01780	COG1349	DNA-binding transcription factor activity
D3H41_01785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3H41_01795	COG2376	Dihydroxyacetone kinase
D3H41_01800	COG1461	Dihydroxyacetone kinase
D3H41_01815	COG3722	fumarate hydratase activity
D3H41_01825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_01825	COG2213	PTS system mannitol-specific
D3H41_01860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3H41_01865	COG0358	DNA primase activity
D3H41_01870	COG1610	YqeY-like protein
D3H41_01875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3H41_01880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3H41_01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3H41_01890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3H41_01895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3H41_01900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3H41_01905	COG1968	undecaprenyl-diphosphatase activity
D3H41_01915	COG3267	Type II secretory pathway component ExeA
D3H41_01915	COG3409	Peptidoglycan-binding domain 1 protein
D3H41_01925	COG0405	Gamma-glutamyltransferase
D3H41_01930	COG4991	sh3 domain protein
D3H41_01935	COG0306	phosphate transporter
D3H41_01940	COG1392	Phosphate transport regulator
D3H41_01945	COG3025	triphosphatase activity
D3H41_01960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3H41_01965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3H41_01965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3H41_01970	COG1538	Outer membrane efflux protein
D3H41_01975	COG0494	nUDIX hydrolase
D3H41_01980	COG3151	Protein conserved in bacteria
D3H41_01990	COG3150	esterase
D3H41_01995	COG0187	DNA topoisomerase II activity
D3H41_02000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3H41_02005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3H41_02015	COG3105	Protein conserved in bacteria
D3H41_02025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3H41_02040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3H41_02045	COG0723	plastoquinol--plastocyanin reductase activity
D3H41_02050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3H41_02055	COG2857	Cytochrome c1
D3H41_02060	COG0625	glutathione transferase activity
D3H41_02065	COG2969	positive regulation of protein catabolic process
D3H41_02070	COG2823	Periplasmic or secreted lipoprotein
D3H41_02075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3H41_02090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3H41_02110	COG3116	cell division
D3H41_02115	COG0768	penicillin binding
D3H41_02120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3H41_02125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3H41_02130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3H41_02135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3H41_02140	COG0772	Belongs to the SEDS family
D3H41_02155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3H41_02160	COG0849	cell division
D3H41_02165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3H41_02170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D3H41_02180	COG0653	protein targeting
D3H41_02185	COG0494	nUDIX hydrolase
D3H41_02195	COG0505	Belongs to the CarA family
D3H41_02200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3H41_02215	COG0730	response to heat
D3H41_02220	COG0583	DNA-binding transcription factor activity
D3H41_02225	COG2860	membrane
D3H41_02240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3H41_02250	COG0493	'glutamate synthase
D3H41_02255	COG0067	glutamate synthase
D3H41_02255	COG0069	glutamate synthase activity
D3H41_02255	COG0070	glutamate synthase
D3H41_02265	COG0067	glutamate synthase
D3H41_02265	COG0069	glutamate synthase activity
D3H41_02265	COG0070	glutamate synthase
D3H41_02270	COG1242	4 iron, 4 sulfur cluster binding
D3H41_02275	COG4251	negative regulation of phosphorylation
D3H41_02275	COG5001	Diguanylate cyclase
D3H41_02275	COG2203	Gaf domain
D3H41_02275	COG3706	GGDEF domain
D3H41_02280	COG0784	Response regulator, receiver
D3H41_02280	COG2198	Histidine kinase
D3H41_02280	COG5002	protein histidine kinase activity
D3H41_02290	COG0745	RESPONSE REGULATOR receiver
D3H41_02305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3H41_02325	COG0083	homoserine kinase activity
D3H41_02330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3H41_02340	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D3H41_02345	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D3H41_02355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3H41_02370	COG1115	amino acid carrier protein
D3H41_02375	COG3022	response to hydroperoxide
D3H41_02380	COG0513	Belongs to the DEAD box helicase family
D3H41_02385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D3H41_02395	COG0716	FMN binding
D3H41_02405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H41_02410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3H41_02425	COG2204	response regulator
D3H41_02435	COG0667	Aldo Keto reductase
D3H41_02460	COG0730	response to heat
D3H41_02470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D3H41_02480	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3H41_02485	COG0583	DNA-binding transcription factor activity
D3H41_02490	COG0640	Transcriptional regulator
D3H41_02495	COG0268	Binds directly to 16S ribosomal RNA
D3H41_02500	COG0728	peptidoglycan biosynthetic process
D3H41_02505	COG0196	riboflavin kinase activity
D3H41_02520	COG1047	Peptidyl-prolyl cis-trans
D3H41_02525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3H41_02535	COG3279	Response regulator of the LytR AlgR family
D3H41_02540	COG3275	phosphorelay sensor kinase activity
D3H41_02545	COG1966	Carbon starvation protein
D3H41_02565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3H41_02570	COG1472	Belongs to the glycosyl hydrolase 3 family
D3H41_02575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H41_02580	COG0287	Prephenate dehydrogenase
D3H41_02580	COG1605	Chorismate mutase
D3H41_02585	COG0739	heme binding
D3H41_02595	COG0488	(ABC) transporter
D3H41_02605	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
D3H41_02610	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D3H41_02615	COG0077	Prephenate dehydratase
D3H41_02615	COG1605	Chorismate mutase
D3H41_02620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3H41_02625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D3H41_02630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_02635	COG0564	pseudouridine synthase activity
D3H41_02645	COG0542	response to heat
D3H41_02710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3H41_02720	COG2974	May be involved in recombination
D3H41_02730	COG0745	RESPONSE REGULATOR receiver
D3H41_02735	COG5002	protein histidine kinase activity
D3H41_02750	COG0248	Ppx GppA phosphatase
D3H41_02755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3H41_02760	COG0573	inorganic phosphate transmembrane transporter activity
D3H41_02765	COG0581	inorganic phosphate transmembrane transporter activity
D3H41_02770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3H41_02775	COG0704	Plays a role in the regulation of phosphate uptake
D3H41_02785	COG3142	Participates in the control of copper homeostasis
D3H41_02790	COG0450	alkyl hydroperoxide reductase
D3H41_02795	COG0583	DNA-binding transcription factor activity
D3H41_02800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3H41_02810	COG0517	IMP dehydrogenase activity
D3H41_02820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3H41_02830	COG1862	Preprotein translocase
D3H41_02835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_02840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_02855	COG0483	inositol monophosphate 1-phosphatase activity
D3H41_02860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D3H41_02870	COG1104	cysteine desulfurase activity
D3H41_02875	COG0822	iron-sulfur transferase activity
D3H41_02890	COG0443	Heat shock 70 kDa protein
D3H41_02895	COG0633	Ferredoxin
D3H41_02900	COG2975	iron-sulfur cluster assembly
D3H41_02910	COG0105	UTP biosynthetic process
D3H41_02925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3H41_02930	COG0124	histidyl-tRNA synthetase
D3H41_02935	COG2976	Protein conserved in bacteria
D3H41_02940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_02945	COG1160	GTP binding
D3H41_02965	COG0516	GMP reductase activity
D3H41_02965	COG0517	IMP dehydrogenase activity
D3H41_02970	COG0519	Catalyzes the synthesis of GMP from XMP
D3H41_02970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3H41_02975	COG0582	viral genome integration into host DNA
D3H41_03135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_03150	COG1757	Na H antiporter
D3H41_03160	COG1584	GPR1 FUN34 yaaH family protein
D3H41_03165	COG1115	amino acid carrier protein
D3H41_03180	COG2873	o-acetylhomoserine
D3H41_03185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3H41_03205	COG3153	acetyltransferase
D3H41_03205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H41_03210	COG0583	DNA-binding transcription factor activity
D3H41_03235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3H41_03240	COG2867	negative regulation of translational initiation
D3H41_03245	COG2914	Belongs to the UPF0125 (RnfH) family
D3H41_03250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3H41_03260	COG0497	DNA recombination
D3H41_03270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D3H41_03275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3H41_03280	COG1301	dicarboxylic acid transport
D3H41_03290	COG0484	heat shock protein binding
D3H41_03320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D3H41_03325	COG0590	tRNA wobble adenosine to inosine editing
D3H41_03335	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D3H41_03340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3H41_03340	COG0047	phosphoribosylformylglycinamidine synthase activity
D3H41_03355	COG1629	transport
D3H41_03370	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3H41_03375	COG2252	PERMEase
D3H41_03380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3H41_03395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D3H41_03400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3H41_03405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3H41_03410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3H41_03410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3H41_03435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3H41_03440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D3H41_03445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3H41_03450	COG0142	geranyltranstransferase activity
D3H41_03455	COG1722	exodeoxyribonuclease VII activity
D3H41_03460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3H41_03470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_03470	COG0301	tRNA thio-modification
D3H41_03475	COG0583	DNA-binding transcription factor activity
D3H41_03485	COG2363	Small membrane protein
D3H41_03495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3H41_03500	COG1611	Belongs to the LOG family
D3H41_03505	COG3706	GGDEF domain
D3H41_03505	COG0745	RESPONSE REGULATOR receiver
D3H41_03515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3H41_03515	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3H41_03525	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D3H41_03530	COG1464	Belongs to the NlpA lipoprotein family
D3H41_03535	COG2011	ABC-type metal ion transport system permease component
D3H41_03540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3H41_03545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3H41_03555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_03555	COG1263	PTS System
D3H41_03560	COG0366	Alpha amylase catalytic
D3H41_03575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D3H41_03580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3H41_03585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3H41_03590	COG0321	lipoyl(octanoyl) transferase activity
D3H41_03600	COG1686	Belongs to the peptidase S11 family
D3H41_03605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3H41_03610	COG0772	Belongs to the SEDS family
D3H41_03615	COG0768	penicillin binding
D3H41_03620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3H41_03625	COG0799	negative regulation of ribosome biogenesis
D3H41_03630	COG1466	dna polymerase III delta subunit
D3H41_03635	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D3H41_03640	COG0495	leucyl-tRNA aminoacylation
D3H41_03645	COG2888	peptidyl-tyrosine sulfation
D3H41_03650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3H41_03655	COG4535	Mg2 and Co2 transporter CorC
D3H41_03660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3H41_03665	COG1702	phosphate starvation-inducible protein PhoH
D3H41_03670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3H41_03680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3H41_03790	COG0012	GTP binding
D3H41_03795	COG0193	aminoacyl-tRNA hydrolase activity
D3H41_03800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3H41_03805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3H41_03810	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D3H41_03815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3H41_03825	COG2890	protein-(glutamine-N5) methyltransferase activity
D3H41_03830	COG3094	Invasion gene expression up-regulator, SirB
D3H41_03835	COG2912	Transglutaminase-like superfamily
D3H41_03840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D3H41_03845	COG0737	Belongs to the 5'-nucleotidase family
D3H41_03850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3H41_03855	COG1187	pseudouridine synthase activity
D3H41_03860	COG2840	Smr protein MutS2
D3H41_03900	COG2217	Heavy metal translocating P-type atpase
D3H41_03900	COG2608	mercury ion transmembrane transporter activity
D3H41_03915	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D3H41_03970	COG0784	Response regulator, receiver
D3H41_03970	COG0835	chemotaxis
D3H41_03975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3H41_03980	COG1815	bacterial-type flagellum-dependent cell motility
D3H41_03985	COG1558	bacterial-type flagellum-dependent cell motility
D3H41_03990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3H41_03995	COG1749	Flagellar hook protein flgE
D3H41_04000	COG4787	bacterial-type flagellum-dependent cell motility
D3H41_04005	COG4786	Flagellar basal body rod
D3H41_04010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3H41_04015	COG1706	bacterial-type flagellum-dependent cell motility
D3H41_04020	COG3951	Flagellar rod assembly protein muramidase FlgJ
D3H41_04020	COG1705	Flagellar rod assembly protein muramidase FlgJ
D3H41_04030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_04035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_04045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_04050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_04060	COG2190	(PTS) system
D3H41_04065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3H41_04070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_04080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3H41_04085	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D3H41_04090	COG3115	cell septum assembly
D3H41_04095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3H41_04120	COG0330	HflC and HflK could
D3H41_04125	COG3118	belongs to the thioredoxin family
D3H41_04135	COG0300	oxidoreductase activity
D3H41_04140	COG1090	epimerase
D3H41_04170	COG0622	Phosphoesterase
D3H41_04190	COG3710	Transcriptional regulator
D3H41_04195	COG0326	Molecular chaperone. Has ATPase activity
D3H41_04205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3H41_04210	COG3104	oligopeptide transport
D3H41_04215	COG0250	Participates in transcription elongation, termination and antitermination
D3H41_04220	COG0367	asparagine synthase
D3H41_04225	COG4651	solute:proton antiporter activity
D3H41_04225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3H41_04230	COG1940	carbohydrate kinase activity
D3H41_04230	COG1846	Transcriptional regulator
D3H41_04235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3H41_04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_04245	COG2190	(PTS) system
D3H41_04245	COG1263	PTS System
D3H41_04250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3H41_04255	COG0735	belongs to the Fur family
D3H41_04265	COG0716	FMN binding
D3H41_04275	COG0596	Alpha beta hydrolase
D3H41_04280	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D3H41_04285	COG0033	Phosphoglucomutase
D3H41_04295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3H41_04305	COG2009	succinate dehydrogenase
D3H41_04310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D3H41_04315	COG1053	succinate dehydrogenase
D3H41_04320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3H41_04325	COG0567	Dehydrogenase, E1 component
D3H41_04330	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3H41_04335	COG0045	succinate-CoA ligase (ADP-forming) activity
D3H41_04345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3H41_04350	COG1121	(ABC) transporter
D3H41_04355	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D3H41_04360	COG4977	sequence-specific DNA binding
D3H41_04365	COG1918	ferrous iron import across plasma membrane
D3H41_04390	COG0018	arginyl-trna synthetase
D3H41_04400	COG3102	Protein conserved in bacteria
D3H41_04415	COG0788	formyltetrahydrofolate deformylase activity
D3H41_04420	COG1199	ATP-dependent helicase activity
D3H41_04425	COG1214	PFAM Peptidase M22, glycoprotease
D3H41_04435	COG3065	identical protein binding
D3H41_04440	COG2267	carboxylic ester hydrolase activity
D3H41_04445	COG0318	PFAM AMP-dependent synthetase and ligase
D3H41_04450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3H41_04460	COG2894	cell division
D3H41_04465	COG0850	regulation of cytokinetic process
D3H41_04470	COG3100	YcgL domain-containing protein
D3H41_04475	COG2951	lytic endotransglycosylase activity
D3H41_04485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3H41_04490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3H41_04505	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_04510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3H41_04515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3H41_04540	COG2986	histidine ammonia-lyase
D3H41_04545	COG1216	Glycosyl transferase, family 2
D3H41_04550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3H41_04565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3H41_04570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3H41_04605	COG0513	Belongs to the DEAD box helicase family
D3H41_04610	COG0569	domain protein
D3H41_04615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_04630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D3H41_04635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3H41_04640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3H41_04645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3H41_04670	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3H41_04680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D3H41_04685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3H41_04690	COG0776	regulation of translation
D3H41_04695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H41_04700	COG1555	photosystem II stabilization
D3H41_04715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3H41_04720	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3H41_04725	COG0436	Aminotransferase
D3H41_04730	COG1169	isochorismate synthase
D3H41_04735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D3H41_04745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3H41_04750	COG1441	menaquinone biosynthetic process
D3H41_04765	COG2855	membrane
D3H41_04770	COG0477	Major facilitator Superfamily
D3H41_04815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_04820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_04840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3H41_04845	COG1522	sequence-specific DNA binding
D3H41_04855	COG1946	Acyl-CoA thioesterase
D3H41_04860	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D3H41_04875	COG3706	GGDEF domain
D3H41_04885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H41_04890	COG0516	GMP reductase activity
D3H41_04890	COG0517	IMP dehydrogenase activity
D3H41_04915	COG0537	adenosine 5'-monophosphoramidase activity
D3H41_04940	COG3150	esterase
D3H41_04945	COG1252	NADH dehydrogenase
D3H41_04960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3H41_04970	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3H41_04975	COG1136	(ABC) transporter
D3H41_04980	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3H41_04990	COG0658	competence protein
D3H41_04990	COG2333	competence protein COMEC
D3H41_05000	COG1132	(ABC) transporter
D3H41_05020	COG2719	SpoVR family
D3H41_05025	COG2718	Belongs to the UPF0229 family
D3H41_05030	COG2766	serine protein kinase
D3H41_05040	COG3013	Belongs to the UPF0304 family
D3H41_05050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3H41_05060	COG1882	Formate acetyltransferase
D3H41_05090	COG4215	(ABC) transporter
D3H41_05105	COG0708	Exodeoxyribonuclease III
D3H41_05115	COG3923	Primosomal replication protein n
D3H41_05120	COG0730	response to heat
D3H41_05125	COG1199	ATP-dependent helicase activity
D3H41_05130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_05135	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D3H41_05140	COG1187	pseudouridine synthase activity
D3H41_05150	COG1278	Cold shock
D3H41_05155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3H41_05160	COG0542	response to heat
D3H41_05165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3H41_05170	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D3H41_05175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D3H41_05195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3H41_05200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3H41_05205	COG0297	glycogen (starch) synthase activity
D3H41_05225	COG3070	regulator of competence-specific genes
D3H41_05230	COG1609	Transcriptional regulator
D3H41_05235	COG3381	protein complex oligomerization
D3H41_05240	COG0745	RESPONSE REGULATOR receiver
D3H41_05245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D3H41_05250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H41_05255	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D3H41_05260	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D3H41_05265	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3H41_05285	COG0189	ligase activity
D3H41_05285	COG4067	protein conserved in archaea
D3H41_05295	COG0500	methyltransferase
D3H41_05305	COG1801	Protein of unknown function DUF72
D3H41_05315	COG0217	transcriptional regulatory protein
D3H41_05320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D3H41_05325	COG0632	four-way junction helicase activity
D3H41_05330	COG2255	four-way junction helicase activity
D3H41_05335	COG1271	oxidase subunit
D3H41_05340	COG1294	oxidase, subunit
D3H41_05345	COG4890	Cyd operon protein YbgT
D3H41_05355	COG0824	Thioesterase
D3H41_05360	COG0811	peptide transport
D3H41_05375	COG0823	Involved in the tonB-independent uptake of proteins
D3H41_05380	COG2885	chlorophyll binding
D3H41_05385	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D3H41_05390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3H41_05400	COG3766	membrane
D3H41_05410	COG0754	glutathionylspermidine amidase activity
D3H41_05420	COG0784	Response regulator, receiver
D3H41_05420	COG5002	protein histidine kinase activity
D3H41_05450	COG0328	RNA-DNA hybrid ribonuclease activity
D3H41_05465	COG1294	oxidase, subunit
D3H41_05470	COG1271	oxidase subunit
D3H41_05490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_05495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_05520	COG3568	Endonuclease Exonuclease Phosphatase
D3H41_05545	COG0583	DNA-binding transcription factor activity
D3H41_05555	COG0686	Belongs to the AlaDH PNT family
D3H41_05565	COG1674	ftsk spoiiie
D3H41_05575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3H41_05595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3H41_05620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3H41_05640	COG0300	oxidoreductase activity
D3H41_05655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3H41_05665	COG2268	Band 7 protein
D3H41_05675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3H41_05680	COG2915	High frequency lysogenization protein hflD homolog
D3H41_05695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_05705	COG1757	Na H antiporter
D3H41_05720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3H41_05730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3H41_05730	COG0131	Imidazoleglycerol-phosphate dehydratase
D3H41_05735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D3H41_05740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D3H41_05745	COG0107	imidazoleglycerol-phosphate synthase activity
D3H41_05750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3H41_05750	COG0140	phosphoribosyl-ATP diphosphatase activity
D3H41_05755	COG3012	SEC-C Motif Domain Protein
D3H41_05760	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D3H41_05765	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_05770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3H41_05775	COG0215	cysteine-tRNA ligase activity
D3H41_05780	COG1435	thymidine kinase activity
D3H41_05785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D3H41_05810	COG2116	formate transmembrane transporter activity
D3H41_05820	COG0390	transport system, permease component
D3H41_05825	COG4459	periplasmic nitrate reductase
D3H41_05830	COG3005	denitrification pathway
D3H41_05835	COG0243	molybdopterin cofactor binding
D3H41_05850	COG1227	inorganic diphosphatase activity
D3H41_05860	COG4172	Belongs to the ABC transporter superfamily
D3H41_05870	COG4171	peptide transport system, permease
D3H41_05875	COG4168	peptide transport system, permease
D3H41_05885	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3H41_05890	COG1842	Phage shock protein A
D3H41_05900	COG1983	PspC domain protein
D3H41_05920	COG2818	Glycosylase
D3H41_05925	COG5380	lipid catabolic process
D3H41_05930	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D3H41_05935	COG0626	cystathionine gamma-synthase activity
D3H41_05945	COG0733	neurotransmitter:sodium symporter activity
D3H41_05950	COG0564	pseudouridine synthase activity
D3H41_05960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3H41_05965	COG1151	hydroxylamine reductase activity
D3H41_05970	COG3604	Transcriptional regulator
D3H41_05985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3H41_05990	COG4136	ATPase activity
D3H41_05995	COG4135	transport system, permease component
D3H41_06000	COG4134	Bacterial extracellular solute-binding protein
D3H41_06010	COG3313	Fe-S protein
D3H41_06035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3H41_06040	COG2205	protein histidine kinase activity
D3H41_06045	COG0745	RESPONSE REGULATOR receiver
D3H41_06055	COG1061	Type III restriction enzyme res subunit
D3H41_06060	COG1187	pseudouridine synthase activity
D3H41_06070	COG2814	Major facilitator Superfamily
D3H41_06080	COG0702	epimerase
D3H41_06085	COG0534	Mate efflux family protein
D3H41_06105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H41_06115	COG1960	acyl-CoA dehydrogenase activity
D3H41_06120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3H41_06125	COG2985	domain, Protein
D3H41_06125	COG3273	potassium ion transport
D3H41_06130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3H41_06140	COG1737	Transcriptional regulator
D3H41_06145	COG0076	glutamate decarboxylase activity
D3H41_06155	COG2431	L-lysine efflux transmembrane transporter activity
D3H41_06175	COG3070	regulator of competence-specific genes
D3H41_06190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_06190	COG4191	Histidine kinase
D3H41_06200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3H41_06210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D3H41_06215	COG4988	ABC transporter
D3H41_06220	COG0492	ferredoxin-NADP+ reductase activity
D3H41_06240	COG3706	GGDEF domain
D3H41_06240	COG0745	RESPONSE REGULATOR receiver
D3H41_06245	COG0471	metal ion transport
D3H41_06250	COG2949	membrane
D3H41_06255	COG0281	malic enzyme
D3H41_06260	COG1643	Atp-dependent helicase
D3H41_06275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3H41_06310	COG0247	lactate metabolic process
D3H41_06310	COG0277	FAD linked oxidase domain protein
D3H41_06325	COG2986	histidine ammonia-lyase
D3H41_06330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3H41_06335	COG0010	Belongs to the arginase family
D3H41_06340	COG1228	amidohydrolase
D3H41_06360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3H41_06370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3H41_06380	COG0393	Putative heavy-metal-binding
D3H41_06415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3H41_06420	COG0072	phenylalanine-tRNA ligase activity
D3H41_06420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H41_06430	COG0776	regulation of translation
D3H41_06440	COG0500	methyltransferase
D3H41_06445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3H41_06455	COG0295	cytidine deaminase activity
D3H41_06460	COG1346	cytolysis
D3H41_06465	COG1380	Effector of murein hydrolase LrgA
D3H41_06470	COG2925	Exonuclease
D3H41_06480	COG0702	epimerase
D3H41_06485	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D3H41_06490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3H41_06510	COG2988	succinylglutamate desuccinylase activity
D3H41_06515	COG4139	cobalamin transport
D3H41_06520	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D3H41_06540	COG0583	DNA-binding transcription factor activity
D3H41_06550	COG1451	nucleotide metabolic process
D3H41_06555	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D3H41_06585	COG3938	Belongs to the proline racemase family
D3H41_06600	COG2423	ornithine cyclodeaminase activity
D3H41_06605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H41_06610	COG3842	ATPase activity
D3H41_06615	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3H41_06620	COG1177	transmembrane transport
D3H41_06630	COG3291	Pkd domain containing protein
D3H41_06650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_06655	COG0601	transmembrane transport
D3H41_06665	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3H41_06675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D3H41_06685	COG0625	glutathione transferase activity
D3H41_06735	COG3755	Protein conserved in bacteria
D3H41_06760	COG1742	UPF0060 membrane protein
D3H41_06775	COG1757	Na H antiporter
D3H41_06780	COG0174	glutamine synthetase
D3H41_06790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3H41_06795	COG1917	Cupin 2, conserved barrel domain protein
D3H41_06795	COG1396	sequence-specific DNA binding
D3H41_06800	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_06805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_06815	COG2957	Belongs to the agmatine deiminase family
D3H41_06820	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_06825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3H41_06830	COG2200	EAL domain
D3H41_06840	COG1846	Transcriptional regulator
D3H41_06845	COG2315	Protein conserved in bacteria
D3H41_06885	COG3063	Type IV pilus biogenesis stability protein PilW
D3H41_06890	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3H41_06905	COG1560	Kdo2-lipid A biosynthetic process
D3H41_06910	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D3H41_06915	COG1280	lysine exporter protein (LysE YggA)
D3H41_06925	COG1115	amino acid carrier protein
D3H41_06950	COG1368	sulfuric ester hydrolase activity
D3H41_06955	COG2113	Glycine betaine
D3H41_06960	COG4176	ABC-type proline glycine betaine transport system permease component
D3H41_06965	COG4175	Glycine betaine
D3H41_06980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_06990	COG0456	acetyltransferase
D3H41_06995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3H41_07000	COG0662	Cupin 2, conserved barrel domain protein
D3H41_07005	COG0527	aspartate kinase activity
D3H41_07010	COG3119	arylsulfatase activity
D3H41_07025	COG0641	radical SAM
D3H41_07040	COG3119	arylsulfatase activity
D3H41_07065	COG1538	Outer membrane efflux protein
D3H41_07080	COG1349	DNA-binding transcription factor activity
D3H41_07085	COG0673	inositol 2-dehydrogenase activity
D3H41_07090	COG4702	Belongs to the UPF0303 family
D3H41_07095	COG0745	RESPONSE REGULATOR receiver
D3H41_07095	COG3706	GGDEF domain
D3H41_07115	COG0471	metal ion transport
D3H41_07130	COG5001	Diguanylate cyclase
D3H41_07130	COG3300	MHYT domain
D3H41_07145	COG1328	CTP reductase activity
D3H41_07150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3H41_07160	COG0861	Integral membrane protein TerC family
D3H41_07170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D3H41_07180	COG0814	amino acid
D3H41_07195	COG1120	ATPase activity
D3H41_07200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3H41_07210	COG4774	siderophore transport
D3H41_07220	COG1132	(ABC) transporter
D3H41_07225	COG1132	(ABC) transporter
D3H41_07240	COG0583	DNA-binding transcription factor activity
D3H41_07265	COG0443	Heat shock 70 kDa protein
D3H41_07270	COG0443	Heat shock 70 kDa protein
D3H41_07315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3H41_07320	COG1643	Atp-dependent helicase
D3H41_07335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_07345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H41_07350	COG1215	transferase activity, transferring glycosyl groups
D3H41_07355	COG0438	transferase activity, transferring glycosyl groups
D3H41_07385	COG0438	transferase activity, transferring glycosyl groups
D3H41_07390	COG0297	glycogen (starch) synthase activity
D3H41_07395	COG2204	response regulator
D3H41_07425	COG1793	dna ligase
D3H41_07435	COG0534	Mate efflux family protein
D3H41_07440	COG0307	riboflavin synthase, alpha
D3H41_07460	COG3706	GGDEF domain
D3H41_07470	COG0791	NLP P60 protein
D3H41_07505	COG1940	carbohydrate kinase activity
D3H41_07520	COG0746	molybdenum cofactor guanylyltransferase activity
D3H41_07525	COG3842	ATPase activity
D3H41_07540	COG2204	response regulator
D3H41_07545	COG4191	Histidine kinase
D3H41_07555	COG0488	(ABC) transporter
D3H41_07560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3H41_07590	COG0243	molybdopterin cofactor binding
D3H41_07590	COG3383	formate dehydrogenase (NAD+) activity
D3H41_07595	COG0437	4 iron, 4 sulfur cluster binding
D3H41_07710	COG0004	ammonium transporteR
D3H41_07715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3H41_07720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3H41_07725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3H41_07730	COG1177	transmembrane transport
D3H41_07735	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3H41_07740	COG3842	ATPase activity
D3H41_07765	COG0589	response to stress
D3H41_07770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_07785	COG2217	Heavy metal translocating P-type atpase
D3H41_07795	COG2010	Cytochrome c
D3H41_07810	COG3278	Belongs to the heme-copper respiratory oxidase family
D3H41_07825	COG2205	protein histidine kinase activity
D3H41_07825	COG0784	Response regulator, receiver
D3H41_08225	COG3120	sequence-specific DNA binding
D3H41_08230	COG1067	ATP-dependent peptidase activity
D3H41_08235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3H41_08260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D3H41_08260	COG0116	Belongs to the methyltransferase superfamily
D3H41_08270	COG0167	dihydroorotate dehydrogenase activity
D3H41_08280	COG2902	Dehydrogenase
D3H41_08290	COG0308	aminopeptidase N
D3H41_08305	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D3H41_08310	COG1956	GAF domain-containing protein
D3H41_08315	COG1132	(ABC) transporter
D3H41_08320	COG2995	paraquat-inducible protein a
D3H41_08325	COG3008	intermembrane lipid transfer
D3H41_08350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H41_08355	COG1666	GTP binding
D3H41_08370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_08375	COG4597	amino acid ABC transporter
D3H41_08380	COG0765	amino acid transport
D3H41_08385	COG1126	abc transporter atp-binding protein
D3H41_08390	COG0670	Belongs to the BI1 family
D3H41_08405	COG2920	part of a sulfur-relay system
D3H41_08410	COG1254	Belongs to the acylphosphatase family
D3H41_08460	COG2199	diguanylate cyclase activity
D3H41_08460	COG2203	Gaf domain
D3H41_08465	COG1414	Transcriptional regulator
D3H41_08475	COG0656	L-ascorbic acid biosynthetic process
D3H41_08480	COG0583	DNA-binding transcription factor activity
D3H41_08490	COG0583	DNA-binding transcription factor activity
D3H41_08495	COG2814	Major facilitator Superfamily
D3H41_08515	COG1335	isochorismatase
D3H41_08535	COG0646	methionine synthase
D3H41_08535	COG1410	methionine synthase
D3H41_08540	COG1126	abc transporter atp-binding protein
D3H41_08545	COG0765	amino acid transport
D3H41_08550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_08565	COG0583	DNA-binding transcription factor activity
D3H41_08580	COG0583	DNA-binding transcription factor activity
D3H41_08590	COG0583	DNA-binding transcription factor activity
D3H41_08605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3H41_08610	COG0602	queuosine metabolic process
D3H41_08615	COG0561	phosphatase activity
D3H41_08640	COG2828	Protein conserved in bacteria
D3H41_08650	COG0372	Belongs to the citrate synthase family
D3H41_08655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3H41_08690	COG0730	response to heat
D3H41_08710	COG0457	Tetratricopeptide repeat
D3H41_08775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3H41_08780	COG4790	Type iii secretion
D3H41_08785	COG4794	Type iii secretion
D3H41_08790	COG4791	protein targeting
D3H41_08795	COG4792	protein secretion
D3H41_08800	COG2207	Transcriptional regulator
D3H41_08830	COG3177	Filamentation induced by cAMP protein fic
D3H41_08850	COG4669	(LipO)protein
D3H41_08920	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_08925	COG3284	Transcriptional regulator
D3H41_08940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3H41_08945	COG0363	glucosamine-6-phosphate deaminase activity
D3H41_08950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D3H41_08955	COG2207	Transcriptional regulator
D3H41_08965	COG4565	transcriptional regulatory protein
D3H41_08970	COG3290	protein histidine kinase activity
D3H41_08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_09015	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3H41_09025	COG2985	domain, Protein
D3H41_09055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3H41_09060	COG0729	surface antigen
D3H41_09070	COG1280	lysine exporter protein (LysE YggA)
D3H41_09075	COG1280	lysine exporter protein (LysE YggA)
D3H41_09080	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3H41_09100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3H41_09105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_09110	COG0110	maltose O-acetyltransferase activity
D3H41_09175	COG2801	Transposase and inactivated derivatives
D3H41_09190	COG2824	Alkylphosphonate utilization operon protein PhnA
D3H41_09655	COG2226	methyltransferase
D3H41_09805	COG1683	Conserved Protein
D3H41_09810	COG0456	acetyltransferase
D3H41_10110	COG1030	water channel activity
D3H41_10140	COG3772	lysozyme
D3H41_10175	COG1403	HNH endonuclease
D3H41_10195	COG1802	Transcriptional regulator
D3H41_10195	COG4626	Terminase
D3H41_10245	COG5532	Uncharacterized conserved protein (DUF2303)
D3H41_10265	COG0582	viral genome integration into host DNA
D3H41_10285	COG0653	protein targeting
D3H41_10300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_10310	COG3768	UPF0283 membrane protein
D3H41_10315	COG3106	COG3106 Predicted ATPase
D3H41_10335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3H41_10340	COG0784	Response regulator, receiver
D3H41_10340	COG2205	protein histidine kinase activity
D3H41_10350	COG0494	nUDIX hydrolase
D3H41_10355	COG0814	amino acid
D3H41_10360	COG1760	l-serine dehydratase
D3H41_10365	COG2200	EAL domain
D3H41_10375	COG0720	synthase
D3H41_10380	COG0840	transmembrane signaling receptor activity
D3H41_10385	COG0017	Asparaginyl-tRNA synthetase
D3H41_10395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_10410	COG1448	Aminotransferase
D3H41_10430	COG0840	transmembrane signaling receptor activity
D3H41_10435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_10465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3H41_10480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H41_10485	COG3108	Peptidase M15
D3H41_10490	COG2989	Protein conserved in bacteria
D3H41_10515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H41_10525	COG4235	cytochrome complex assembly
D3H41_10525	COG3088	subunit of a heme lyase
D3H41_10535	COG1138	Cytochrome C-type biogenesis protein
D3H41_10540	COG3301	Polysulphide reductase, NrfD
D3H41_10545	COG0437	4 iron, 4 sulfur cluster binding
D3H41_10555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D3H41_10575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H41_10585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3H41_10590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3H41_10615	COG0019	diaminopimelate decarboxylase activity
D3H41_10655	COG0322	excinuclease ABC activity
D3H41_10660	COG2197	response regulator
D3H41_10665	COG0417	DNA replication proofreading
D3H41_10685	COG1187	pseudouridine synthase activity
D3H41_10695	COG0009	L-threonylcarbamoyladenylate synthase
D3H41_10700	COG0613	PHP domain protein
D3H41_10710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3H41_10715	COG0512	Glutamine amidotransferase of anthranilate synthase
D3H41_10725	COG0134	indole-3-glycerol-phosphate synthase activity
D3H41_10725	COG0135	phosphoribosylanthranilate isomerase activity
D3H41_10735	COG0159	tryptophan synthase activity
D3H41_10740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_10745	COG0318	PFAM AMP-dependent synthetase and ligase
D3H41_10755	COG1301	dicarboxylic acid transport
D3H41_10775	COG2917	probably involved in intracellular septation
D3H41_10780	COG1607	acyl-coa hydrolase
D3H41_10785	COG2350	Protein conserved in bacteria
D3H41_10795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D3H41_10800	COG0583	DNA-binding transcription factor activity
D3H41_10815	COG5001	Diguanylate cyclase
D3H41_10820	COG1032	radical SAM domain protein
D3H41_10840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D3H41_10845	COG0463	Glycosyl transferase, family 2
D3H41_10850	COG0745	RESPONSE REGULATOR receiver
D3H41_10855	COG5002	protein histidine kinase activity
D3H41_10855	COG3850	Histidine kinase
D3H41_10890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D3H41_10910	COG0577	efflux transmembrane transporter activity
D3H41_10910	COG1136	(ABC) transporter
D3H41_10915	COG1136	(ABC) transporter
D3H41_10915	COG0577	efflux transmembrane transporter activity
D3H41_10920	COG0577	efflux transmembrane transporter activity
D3H41_10920	COG1136	(ABC) transporter
D3H41_10930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_10950	COG3118	belongs to the thioredoxin family
D3H41_11010	COG4232	protein-disulfide reductase activity
D3H41_11015	COG3118	belongs to the thioredoxin family
D3H41_11060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_11080	COG3118	belongs to the thioredoxin family
D3H41_11085	COG4232	protein-disulfide reductase activity
D3H41_11120	COG2863	cytochrome
D3H41_11125	COG3258	Cytochrome c
D3H41_11130	COG2995	paraquat-inducible protein a
D3H41_11135	COG3008	intermembrane lipid transfer
D3H41_11135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3H41_11155	COG4166	transmembrane transport
D3H41_11165	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D3H41_11170	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D3H41_11180	COG0539	negative regulation of cytoplasmic translation
D3H41_11185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D3H41_11190	COG0616	signal peptide processing
D3H41_11195	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_11210	COG0587	DNA-directed DNA polymerase activity
D3H41_11215	COG0835	chemotaxis
D3H41_11215	COG0784	Response regulator, receiver
D3H41_11220	COG1940	carbohydrate kinase activity
D3H41_11225	COG0469	pyruvate kinase activity
D3H41_11230	COG4667	esterase of the alpha-beta hydrolase superfamily
D3H41_11245	COG0733	neurotransmitter:sodium symporter activity
D3H41_11260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_11260	COG1263	PTS System
D3H41_11265	COG0084	hydrolase, TatD family'
D3H41_11270	COG0470	DNA polymerase III
D3H41_11275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3H41_11280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3H41_11310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_11315	COG0416	fatty acid biosynthetic process
D3H41_11325	COG1399	metal-binding, possibly nucleic acid-binding protein
D3H41_11330	COG0424	maF-like protein
D3H41_11335	COG0564	pseudouridine synthase activity
D3H41_11345	COG1530	ribonuclease E activity
D3H41_11355	COG0659	secondary active sulfate transmembrane transporter activity
D3H41_11360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3H41_11365	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D3H41_11375	COG0572	uridine kinase
D3H41_11385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H41_11385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3H41_11405	COG2186	Transcriptional regulator
D3H41_11410	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3H41_11415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D3H41_11420	COG3012	SEC-C Motif Domain Protein
D3H41_11420	COG3318	Belongs to the UPF0149 family
D3H41_11425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3H41_11430	COG3706	GGDEF domain
D3H41_11435	COG0366	Alpha amylase catalytic
D3H41_11440	COG1122	ATPase activity
D3H41_11445	COG4120	Belongs to the binding-protein-dependent transport system permease family
D3H41_11455	COG3092	negative regulation of chromosome organization
D3H41_11460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3H41_11465	COG0280	phosphate acetyltransferase
D3H41_11465	COG0857	belongs to the CobB CobQ family
D3H41_11475	COG0435	Glutathione S-transferase
D3H41_11485	COG0444	Belongs to the ABC transporter superfamily
D3H41_11490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_11495	COG0601	transmembrane transport
D3H41_11505	COG0314	molybdopterin synthase activity
D3H41_11510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3H41_11515	COG0315	cyclic pyranopterin monophosphate synthase activity
D3H41_11520	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3H41_11525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3H41_11530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D3H41_11535	COG2198	Histidine kinase
D3H41_11540	COG2204	response regulator
D3H41_11545	COG0556	nucleotide-excision repair
D3H41_11555	COG1882	Formate acetyltransferase
D3H41_11560	COG4657	Part of a membrane complex involved in electron transport
D3H41_11565	COG2878	Part of a membrane complex involved in electron transport
D3H41_11570	COG4656	Part of a membrane complex involved in electron transport
D3H41_11575	COG4658	electron transport chain
D3H41_11580	COG4659	FMN binding
D3H41_11585	COG4660	Part of a membrane complex involved in electron transport
D3H41_11590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3H41_11595	COG0346	lactoylglutathione lyase activity
D3H41_11605	COG2885	chlorophyll binding
D3H41_11615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3H41_11620	COG2056	Na+-H+ antiporter family
D3H41_11640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3H41_11660	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_11660	COG1454	alcohol dehydrogenase
D3H41_11665	COG2095	MarC family integral membrane protein
D3H41_11670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_11675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3H41_11680	COG1757	Na H antiporter
D3H41_11695	COG3081	Nucleoid-associated protein
D3H41_11700	COG3082	Protein of unknown function (DUF1414)
D3H41_11705	COG3083	sulfuric ester hydrolase activity
D3H41_11715	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3H41_11730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3H41_11735	COG0778	Nitroreductase
D3H41_11745	COG1902	pentaerythritol trinitrate reductase activity
D3H41_11745	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3H41_11750	COG0616	signal peptide processing
D3H41_11755	COG0252	asparaginase activity
D3H41_11760	COG3139	Protein of unknown function (DUF1315)
D3H41_11770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_11775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3H41_11790	COG2226	methyltransferase
D3H41_11810	COG1785	Belongs to the alkaline phosphatase family
D3H41_11820	COG0346	lactoylglutathione lyase activity
D3H41_11825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D3H41_11830	COG0668	transmembrane transport
D3H41_11835	COG2983	Belongs to the UPF0260 family
D3H41_11840	COG2261	transglycosylase associated protein
D3H41_11850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H41_11855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D3H41_11860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3H41_11870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3H41_11875	COG2832	Protein of unknown function (DUF454)
D3H41_11885	COG0745	RESPONSE REGULATOR receiver
D3H41_11890	COG0583	DNA-binding transcription factor activity
D3H41_11895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3H41_11900	COG1286	toxin biosynthetic process
D3H41_11905	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D3H41_11910	COG0285	dihydrofolate synthase activity
D3H41_11915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3H41_11925	COG0101	tRNA pseudouridine synthase activity
D3H41_11935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3H41_11940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H41_11950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3H41_11955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_11955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D3H41_11960	COG0431	NADPH-dependent FMN reductase
D3H41_11975	COG3101	peptidyl-lysine hydroxylation
D3H41_11985	COG2860	membrane
D3H41_11990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3H41_11995	COG2890	protein-(glutamine-N5) methyltransferase activity
D3H41_12000	COG2840	Smr protein MutS2
D3H41_12005	COG2062	phosphohistidine phosphatase, SixA
D3H41_12020	COG1024	Enoyl-CoA hydratase
D3H41_12020	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3H41_12025	COG0183	Belongs to the thiolase family
D3H41_12050	COG2067	long-chain fatty acid transport protein
D3H41_12060	COG3088	subunit of a heme lyase
D3H41_12060	COG4235	cytochrome complex assembly
D3H41_12070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3H41_12075	COG1138	Cytochrome C-type biogenesis protein
D3H41_12080	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3H41_12085	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3H41_12090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3H41_12095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3H41_12100	COG4133	protoheme IX ABC transporter activity
D3H41_12110	COG0835	chemotaxis
D3H41_12120	COG1192	Involved in chromosome partitioning
D3H41_12125	COG2201	protein-glutamate methylesterase activity
D3H41_12130	COG2198	Histidine kinase
D3H41_12130	COG0643	Histidine kinase
D3H41_12135	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D3H41_12150	COG0455	bacterial-type flagellum organization
D3H41_12170	COG1684	flagellar biosynthetic protein fliR
D3H41_12175	COG1987	bacterial-type flagellum assembly
D3H41_12230	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3H41_12240	COG1677	Flagellar hook-basal body complex protein FliE
D3H41_12245	COG2204	response regulator
D3H41_12250	COG4191	Histidine kinase
D3H41_12255	COG2204	response regulator
D3H41_12260	COG1516	flagellar protein fliS
D3H41_12270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D3H41_12275	COG1334	flagellar protein FlaG
D3H41_12280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_12285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_12295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_12300	COG2837	iron assimilation
D3H41_12325	COG1393	Belongs to the ArsC family
D3H41_12330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H41_12350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3H41_12360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3H41_12375	COG4783	chaperone-mediated protein folding
D3H41_12380	COG1393	Belongs to the ArsC family
D3H41_12400	COG2233	PERMEase
D3H41_12405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3H41_12410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3H41_12415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3H41_12420	COG0121	glutamine amidotransferase
D3H41_12425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3H41_12430	COG1960	acyl-CoA dehydrogenase activity
D3H41_12460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3H41_12465	COG0328	RNA-DNA hybrid ribonuclease activity
D3H41_12470	COG2226	methyltransferase
D3H41_12475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H41_12480	COG0741	lytic transglycosylase activity
D3H41_12480	COG1388	LysM domain
D3H41_12490	COG3021	interspecies interaction between organisms
D3H41_12495	COG0347	Belongs to the P(II) protein family
D3H41_12510	COG0825	malonyl-CoA metabolic process
D3H41_12515	COG0587	DNA-directed DNA polymerase activity
D3H41_12525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_12530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_12540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3H41_12545	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D3H41_12555	COG0750	zinc metalloprotease
D3H41_12560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3H41_12565	COG0575	Belongs to the CDS family
D3H41_12570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3H41_12575	COG0233	cytoplasmic translational termination
D3H41_12580	COG0528	UMP kinase activity
D3H41_12585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3H41_12590	COG0052	Belongs to the universal ribosomal protein uS2 family
D3H41_12595	COG0024	Methionine aminopeptidase
D3H41_12600	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3H41_12610	COG0564	pseudouridine synthase activity
D3H41_12615	COG3098	single-species biofilm formation
D3H41_12650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_12655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H41_12680	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D3H41_12690	COG0254	rRNA binding
D3H41_12695	COG1720	tRNA m6t6A37 methyltransferase activity
D3H41_12700	COG0442	prolyl-tRNA aminoacylation
D3H41_12720	COG0733	neurotransmitter:sodium symporter activity
D3H41_12735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_12740	COG0514	ATP-dependent DNA helicase (RecQ)
D3H41_12745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3H41_12755	COG3706	GGDEF domain
D3H41_12755	COG0745	RESPONSE REGULATOR receiver
D3H41_12765	COG1477	protein flavinylation
D3H41_12770	COG2871	sodium ion transport
D3H41_12775	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_12780	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_12785	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_12790	COG1805	sodium ion transport
D3H41_12795	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D3H41_12800	COG0271	Belongs to the BolA IbaG family
D3H41_12805	COG2813	Specifically methylates the guanine in position
D3H41_12810	COG3056	Lipoprotein
D3H41_12830	COG1595	DNA-templated transcription, initiation
D3H41_12850	COG3248	Nucleoside-binding outer membrane protein
D3H41_12855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3H41_12860	COG0693	protein deglycase activity
D3H41_12865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3H41_12870	COG3706	GGDEF domain
D3H41_12875	COG2166	iron-sulfur cluster assembly
D3H41_12880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D3H41_12885	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3H41_12900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3H41_12900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3H41_12920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3H41_12925	COG1074	ATP-dependent DNA helicase activity
D3H41_12930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D3H41_12950	COG3141	response to X-ray
D3H41_12965	COG2171	N-acyltransferase activity
D3H41_12970	COG0584	glycerophosphoryl diester phosphodiesterase
D3H41_12975	COG2271	Major facilitator Superfamily
D3H41_12985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3H41_12990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3H41_12995	COG1349	DNA-binding transcription factor activity
D3H41_13000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3H41_13005	COG0598	Magnesium transport protein CorA
D3H41_13025	COG1609	Transcriptional regulator
D3H41_13030	COG0583	DNA-binding transcription factor activity
D3H41_13090	COG4964	Belongs to the GSP D family
D3H41_13115	COG2169	Transcriptional regulator
D3H41_13120	COG1022	Amp-dependent synthetase and ligase
D3H41_13130	COG0583	DNA-binding transcription factor activity
D3H41_13135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3H41_13140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D3H41_13150	COG0560	Phosphoserine phosphatase
D3H41_13160	COG0813	purine-nucleoside phosphorylase activity
D3H41_13165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D3H41_13170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D3H41_13175	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3H41_13180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3H41_13185	COG0084	hydrolase, TatD family'
D3H41_13215	COG3153	acetyltransferase
D3H41_13245	COG0534	Mate efflux family protein
D3H41_13260	COG1185	polyribonucleotide nucleotidyltransferase activity
D3H41_13265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3H41_13270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3H41_13275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D3H41_13280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D3H41_13285	COG0195	Participates in both transcription termination and antitermination
D3H41_13290	COG0779	Required for maturation of 30S ribosomal subunits
D3H41_13305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3H41_13315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_13320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3H41_13325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3H41_13330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D3H41_13335	COG1534	Rna-binding protein
D3H41_13340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_13345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_13350	COG2027	D-alanyl-D-alanine carboxypeptidase
D3H41_13360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3H41_13365	COG0739	heme binding
D3H41_13390	COG0628	permease
D3H41_13405	COG0747	negative chemotaxis
D3H41_13415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3H41_13420	COG0444	Belongs to the ABC transporter superfamily
D3H41_13425	COG4608	Belongs to the ABC transporter superfamily
D3H41_13435	COG2971	BadF BadG BcrA BcrD
D3H41_13450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_13455	COG3842	ATPase activity
D3H41_13465	COG1840	ABC-type Fe3 transport system, periplasmic component
D3H41_13470	COG0004	ammonium transporteR
D3H41_13480	COG3112	Uncharacterised protein family (UPF0231)
D3H41_13485	COG1049	propionate catabolic process, 2-methylcitrate cycle
D3H41_13490	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3H41_13495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3H41_13500	COG1643	Atp-dependent helicase
D3H41_13505	COG1489	DNA binding
D3H41_13510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3H41_13515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3H41_13525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3H41_13530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3H41_13535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D3H41_13540	COG1560	Kdo2-lipid A biosynthetic process
D3H41_13550	COG0842	Transport permease protein
D3H41_13555	COG1131	(ABC) transporter
D3H41_13560	COG0659	secondary active sulfate transmembrane transporter activity
D3H41_13565	COG0288	reversible hydration of carbon dioxide
D3H41_13580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_13585	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3H41_13590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D3H41_13595	COG2186	Transcriptional regulator
D3H41_13605	COG0157	Belongs to the NadC ModD family
D3H41_13615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3H41_13620	COG1459	type II secretion system
D3H41_13630	COG0237	dephospho-CoA kinase activity
D3H41_13635	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D3H41_13640	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D3H41_13660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3H41_13665	COG0228	four-way junction DNA binding
D3H41_13670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3H41_13675	COG4137	Cytochrome C assembly protein
D3H41_13680	COG4536	flavin adenine dinucleotide binding
D3H41_13685	COG1854	S-ribosylhomocysteine lyase activity
D3H41_13700	COG0612	Peptidase, M16
D3H41_13705	COG1238	metal cluster binding
D3H41_13715	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D3H41_13720	COG5016	pyruvate
D3H41_13720	COG0511	ligase activity, forming carbon-carbon bonds
D3H41_13785	COG0527	aspartate kinase activity
D3H41_13790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3H41_13795	COG2137	regulation of response to DNA damage stimulus
D3H41_13805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D3H41_13810	COG1546	Belongs to the CinA family
D3H41_13815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3H41_13820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3H41_13830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3H41_13835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D3H41_13845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3H41_13850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D3H41_13855	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3H41_13860	COG0148	phosphopyruvate hydratase activity
D3H41_13865	COG0504	CTP synthase activity
D3H41_13870	COG3956	TIGRFAM MazG family protein
D3H41_13875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3H41_13885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3H41_13900	COG0736	holo-[acyl-carrier-protein] synthase activity
D3H41_13905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3H41_13910	COG1381	Involved in DNA repair and RecF pathway recombination
D3H41_13915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3H41_13925	COG0681	Belongs to the peptidase S26 family
D3H41_13930	COG0481	GTPase activity
D3H41_13935	COG3086	response to oxidative stress
D3H41_13950	COG1595	DNA-templated transcription, initiation
D3H41_13960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3H41_13970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D3H41_13990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3H41_13995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3H41_14000	COG3079	Belongs to the UPF0149 family
D3H41_14010	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D3H41_14020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3H41_14025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D3H41_14030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3H41_14040	COG0583	DNA-binding transcription factor activity
D3H41_14055	COG0668	transmembrane transport
D3H41_14060	COG0191	fructose-bisphosphate aldolase activity
D3H41_14075	COG4771	TonB-dependent receptor
D3H41_14080	COG0583	DNA-binding transcription factor activity
D3H41_14085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3H41_14095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3H41_14110	COG2356	endonuclease I
D3H41_14115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3H41_14120	COG0189	ligase activity
D3H41_14125	COG1678	Uncharacterized ACR, COG1678
D3H41_14130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3H41_14145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3H41_14150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3H41_14155	COG0762	integral membrane protein
D3H41_14160	COG1872	DUF167
D3H41_14170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3H41_14175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3H41_14180	COG2066	Belongs to the glutaminase family
D3H41_14190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3H41_14200	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D3H41_14245	COG0840	transmembrane signaling receptor activity
D3H41_14325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D3H41_14335	COG3394	polysaccharide catabolic process
D3H41_14340	COG1486	melibiose metabolic process
D3H41_14345	COG1447	Phosphotransferase system cellobiose-specific component IIA
D3H41_14350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D3H41_14360	COG0726	polysaccharide deacetylase
D3H41_14370	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_14375	COG4325	translation initiation factor activity
D3H41_14385	COG0795	lipopolysaccharide-transporting ATPase activity
D3H41_14390	COG0795	lipopolysaccharide-transporting ATPase activity
D3H41_14395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3H41_14400	COG2927	DNA polymerase III (CHI subunit)
D3H41_14405	COG0525	valine-tRNA ligase activity
D3H41_14415	COG0456	acetyltransferase
D3H41_14445	COG0540	Belongs to the ATCase OTCase family
D3H41_14450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D3H41_14455	COG0251	oxidation-reduction process
D3H41_14460	COG0204	Acyl-transferase
D3H41_14465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3H41_14470	COG5007	Belongs to the BolA IbaG family
D3H41_14480	COG2854	intermembrane phospholipid transfer
D3H41_14485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3H41_14490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3H41_14495	COG1127	ABC transporter
D3H41_14505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D3H41_14505	COG0517	IMP dehydrogenase activity
D3H41_14515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D3H41_14520	COG1137	ATPase activity
D3H41_14530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3H41_14535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_14540	COG1660	Displays ATPase and GTPase activities
D3H41_14545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_14550	COG2239	Acts as a magnesium transporter
D3H41_14555	COG0312	modulator of DNA gyrase
D3H41_14560	COG3028	Belongs to the UPF0307 family
D3H41_14565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3H41_14570	COG0564	pseudouridine synthase activity
D3H41_14580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3H41_14585	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D3H41_14590	COG0312	modulator of DNA gyrase
D3H41_14595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3H41_14600	COG3164	Protein of unknown function
D3H41_14605	COG1530	ribonuclease E activity
D3H41_14610	COG0424	maF-like protein
D3H41_14615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D3H41_14620	COG1792	Involved in formation and maintenance of cell shape
D3H41_14625	COG1077	Cell shape determining protein MreB Mrl
D3H41_14670	COG1459	type II secretion system
D3H41_14675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3H41_14685	COG3267	Type II secretory pathway component ExeA
D3H41_14685	COG3409	Peptidoglycan-binding domain 1 protein
D3H41_14690	COG1450	Type ii and iii secretion system protein
D3H41_14710	COG2199	diguanylate cyclase activity
D3H41_14710	COG2200	EAL domain
D3H41_14715	COG0629	single-stranded DNA binding
D3H41_14730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3H41_14740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D3H41_14750	COG0527	aspartate kinase activity
D3H41_14755	COG1410	methionine synthase
D3H41_14755	COG0646	methionine synthase
D3H41_14820	COG0175	sulfate reduction
D3H41_14825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_14830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3H41_14850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3H41_14855	COG0735	belongs to the Fur family
D3H41_14865	COG0166	Belongs to the GPI family
D3H41_14870	COG0432	Pfam Uncharacterised protein family UPF0047
D3H41_14875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3H41_14880	COG0305	Participates in initiation and elongation during chromosome replication
D3H41_14900	COG2965	DNA replication, synthesis of RNA primer
D3H41_14905	COG0360	Binds together with S18 to 16S ribosomal RNA
D3H41_14910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3H41_14915	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D3H41_14925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3H41_14930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3H41_14960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3H41_14970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3H41_14970	COG0678	peroxiredoxin activity
D3H41_14975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_14985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3H41_14985	COG0165	Argininosuccinate lyase
D3H41_14990	COG0137	argininosuccinate synthase activity
D3H41_15000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3H41_15010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3H41_15020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D3H41_15025	COG0527	aspartate kinase activity
D3H41_15025	COG0460	homoserine dehydrogenase
D3H41_15030	COG0626	cystathionine gamma-synthase activity
D3H41_15040	COG0281	malic enzyme
D3H41_15050	COG2906	2 iron, 2 sulfur cluster binding
D3H41_15055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3H41_15060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3H41_15080	COG2923	Belongs to the DsrF TusC family
D3H41_15085	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D3H41_15090	COG2964	Protein conserved in bacteria
D3H41_15095	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H41_15110	COG1446	asparaginase
D3H41_15120	COG1047	Peptidyl-prolyl cis-trans
D3H41_15135	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3H41_15140	COG0488	(ABC) transporter
D3H41_15150	COG0429	hydrolase of the alpha beta-hydrolase fold
D3H41_15160	COG3954	Phosphoribulokinase
D3H41_15165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3H41_15185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3H41_15190	COG0512	Glutamine amidotransferase of anthranilate synthase
D3H41_15205	COG0180	Tryptophanyl-tRNA synthetase
D3H41_15210	COG0546	phosphoglycolate phosphatase activity
D3H41_15215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3H41_15220	COG0557	exoribonuclease II activity
D3H41_15225	COG1959	2 iron, 2 sulfur cluster binding
D3H41_15230	COG1017	nitric oxide dioxygenase activity
D3H41_15230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3H41_15235	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D3H41_15245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3H41_15250	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D3H41_15255	COG0330	HflC and HflK could
D3H41_15260	COG0330	HflC and HflK could
D3H41_15265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3H41_15275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3H41_15280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3H41_15290	COG0802	atpase or kinase
D3H41_15300	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3H41_15365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D3H41_15370	COG1162	GTPase activity
D3H41_15375	COG0688	phosphatidylethanolamine metabolic process
D3H41_15380	COG0471	metal ion transport
D3H41_15380	COG3273	potassium ion transport
D3H41_15390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3H41_15395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_15400	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3H41_15405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3H41_15410	COG1045	serine acetyltransferase
D3H41_15415	COG4942	peptidase
D3H41_15435	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D3H41_15440	COG1053	succinate dehydrogenase
D3H41_15445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3H41_15450	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D3H41_15455	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D3H41_15470	COG1509	lysine 2,3-aminomutase activity
D3H41_15475	COG1285	pathogenesis
D3H41_15485	COG0459	protein refolding
D3H41_15490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3H41_15495	COG0534	Mate efflux family protein
D3H41_15500	COG0205	6-phosphofructokinase activity
D3H41_15510	COG3678	ATP-independent chaperone mediated protein folding
D3H41_15515	COG0745	RESPONSE REGULATOR receiver
D3H41_15520	COG2205	protein histidine kinase activity
D3H41_15530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3H41_15540	COG1027	Aspartate ammonia-lyase
D3H41_15545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3H41_15550	COG4232	protein-disulfide reductase activity
D3H41_15560	COG3263	regulation of cellular component size
D3H41_15570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_15590	COG0784	Response regulator, receiver
D3H41_15590	COG2205	protein histidine kinase activity
D3H41_15590	COG2198	Histidine kinase
D3H41_15595	COG2814	Major facilitator Superfamily
D3H41_15610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3H41_15615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3H41_15620	COG0511	ligase activity, forming carbon-carbon bonds
D3H41_15625	COG0439	Biotin carboxylase
D3H41_15635	COG2264	protein methyltransferase activity
D3H41_15640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3H41_15645	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D3H41_15655	COG0488	(ABC) transporter
D3H41_15720	COG1982	Orn Lys Arg decarboxylase major
D3H41_15725	COG0531	amino acid
D3H41_15735	COG3710	Transcriptional regulator
D3H41_15750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3H41_15755	COG0222	ribosome binding
D3H41_15775	COG2816	NAD+ diphosphatase activity
D3H41_15780	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D3H41_15790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3H41_15795	COG0085	RNA polymerase activity
D3H41_15800	COG0222	ribosome binding
D3H41_15805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3H41_15820	COG0250	Participates in transcription elongation, termination and antitermination
D3H41_15825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3H41_15835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3H41_15870	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D3H41_15870	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D3H41_15875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3H41_15885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3H41_15950	COG4206	TonB-dependent receptor
D3H41_15970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3H41_15975	COG0534	Mate efflux family protein
D3H41_15980	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D3H41_15990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3H41_16000	COG2937	Belongs to the GPAT DAPAT family
D3H41_16005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3H41_16010	COG3161	chorismate lyase activity
D3H41_16015	COG1580	Controls the rotational direction of flagella during chemotaxis
D3H41_16020	COG0705	Rhomboid family
D3H41_16025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_16040	COG2177	Part of the ABC transporter FtsEX involved in
D3H41_16045	COG2884	Cell division ATP-binding protein ftsE
D3H41_16050	COG0552	protein localization to endoplasmic reticulum
D3H41_16055	COG0742	ribosomal rna small subunit methyltransferase
D3H41_16065	COG2095	MarC family integral membrane protein
D3H41_16110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3H41_16115	COG0640	Transcriptional regulator
D3H41_16120	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D3H41_16125	COG1280	lysine exporter protein (LysE YggA)
D3H41_16130	COG2267	carboxylic ester hydrolase activity
D3H41_16135	COG0561	phosphatase activity
D3H41_16155	COG3287	FIST C domain
D3H41_16155	COG2199	diguanylate cyclase activity
D3H41_16155	COG2200	EAL domain
D3H41_16160	COG1011	Hydrolase
D3H41_16165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D3H41_16180	COG0019	diaminopimelate decarboxylase activity
D3H41_16190	COG1965	Belongs to the frataxin family
D3H41_16195	COG3072	Adenylate cyclase
D3H41_16200	COG0181	hydroxymethylbilane synthase activity
D3H41_16205	COG1587	Uroporphyrinogen-III synthase
D3H41_16210	COG2959	enzyme of heme biosynthesis
D3H41_16215	COG3071	HemY protein
D3H41_16260	COG0633	Ferredoxin
D3H41_16265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3H41_16275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3H41_16280	COG3118	belongs to the thioredoxin family
D3H41_16285	COG0513	Belongs to the DEAD box helicase family
D3H41_16290	COG0248	Ppx GppA phosphatase
D3H41_16300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D3H41_16315	COG0514	ATP-dependent DNA helicase (RecQ)
D3H41_16320	COG2962	Rard protein
D3H41_16330	COG1280	lysine exporter protein (LysE YggA)
D3H41_16335	COG0405	Gamma-glutamyltransferase
D3H41_16345	COG0210	DNA helicase
D3H41_16355	COG3220	belongs to the UPF0276 family
D3H41_16385	COG0006	proline dipeptidase activity
D3H41_16385	COG0006	proline dipeptidase activity
D3H41_16400	COG2104	thiamine diphosphate biosynthetic process
D3H41_16405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3H41_16425	COG2132	Multicopper oxidase
D3H41_16470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3H41_16485	COG0408	coproporphyrinogen oxidase activity
D3H41_16490	COG0009	L-threonylcarbamoyladenylate synthase
D3H41_16495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3H41_16500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3H41_16505	COG1943	Transposase
D3H41_16510	COG0551	DNA topoisomerase type I activity
D3H41_16520	COG2922	Belongs to the Smg family
D3H41_16525	COG0758	DNA mediated transformation
D3H41_16535	COG0242	peptide deformylase activity
D3H41_16540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3H41_16545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3H41_16545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3H41_16550	COG0569	domain protein
D3H41_16555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_16565	COG1272	protein, Hemolysin III
D3H41_16570	COG4326	sporulation control protein
D3H41_16580	COG3084	Protein conserved in bacteria
D3H41_16590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3H41_16595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H41_16600	COG0204	Acyl-transferase
D3H41_16610	COG0606	chelatase, subunit chli
D3H41_16620	COG3978	acetolactate synthase activity
D3H41_16625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3H41_16630	COG0129	dihydroxy-acid dehydratase activity
D3H41_16640	COG0583	DNA-binding transcription factor activity
D3H41_16645	COG2814	Major facilitator Superfamily
D3H41_16655	COG0765	amino acid transport
D3H41_16665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D3H41_16670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3H41_16675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3H41_16680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3H41_16685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3H41_16690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3H41_16700	COG0356	it plays a direct role in the translocation of protons across the membrane
D3H41_16705	COG3312	ion transport
D3H41_16710	COG1475	DNA binding
D3H41_16715	COG1192	Involved in chromosome partitioning
D3H41_16720	COG0357	Ribosomal RNA small subunit methyltransferase G
D3H41_16725	COG0445	tRNA wobble uridine modification
D3H41_16730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3H41_16745	COG1395	domain, Protein
D3H41_16780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D3H41_16815	COG4974	Belongs to the 'phage' integrase family
D3H41_16825	COG0706	membrane insertase activity
D3H41_16830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3H41_16835	COG0594	ribonuclease P activity
D3H41_16845	COG1126	abc transporter atp-binding protein
D3H41_16870	COG0730	response to heat
D3H41_16880	COG0513	Belongs to the DEAD box helicase family
D3H41_16885	COG4628	conserved protein (DUF2132)
D3H41_16895	COG0133	tryptophan synthase activity
D3H41_16905	COG1278	Cold shock
D3H41_16915	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D3H41_16925	COG0523	cobalamin synthesis protein
D3H41_16930	COG0513	Belongs to the DEAD box helicase family
D3H41_16950	COG2200	EAL domain
D3H41_16955	COG1119	ATPase activity
D3H41_16980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3H41_16995	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D3H41_17000	COG0513	Belongs to the DEAD box helicase family
D3H41_17020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3H41_17030	COG1073	alpha beta
D3H41_17035	COG1073	alpha beta
D3H41_17125	COG0247	lactate metabolic process
D3H41_17125	COG0277	FAD linked oxidase domain protein
D3H41_17140	COG1024	Enoyl-CoA hydratase
D3H41_17145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3H41_17150	COG1960	acyl-CoA dehydrogenase activity
D3H41_17160	COG0183	Belongs to the thiolase family
D3H41_17175	COG1024	Enoyl-CoA hydratase
D3H41_17180	COG1024	Enoyl-CoA hydratase
D3H41_17190	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_17195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3H41_17200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3H41_17205	COG1845	cytochrome c oxidase, subunit III
D3H41_17210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D3H41_17215	COG0109	protoheme IX farnesyltransferase activity
D3H41_17225	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3H41_17225	COG1902	pentaerythritol trinitrate reductase activity
D3H41_17240	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_17250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_17280	COG1126	abc transporter atp-binding protein
D3H41_17285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_17290	COG4215	(ABC) transporter
D3H41_17295	COG4160	amino acid transport
D3H41_17360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_17365	COG2176	DNA-directed DNA polymerase activity
D3H41_17370	COG0517	IMP dehydrogenase activity
D3H41_17375	COG2186	Transcriptional regulator
D3H41_17380	COG2186	Transcriptional regulator
D3H41_17425	COG1917	Cupin 2, conserved barrel domain protein
D3H41_17430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_17435	COG0800	Aldolase
D3H41_17445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3H41_17450	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_17455	COG2847	Copper chaperone PCu(A)C
D3H41_17520	COG3706	GGDEF domain
D3H41_17530	COG0814	amino acid
D3H41_17540	COG0243	molybdopterin cofactor binding
D3H41_17560	COG3707	response regulator
D3H41_17570	COG1116	anion transmembrane transporter activity
D3H41_17570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3H41_17575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3H41_17580	COG1116	anion transmembrane transporter activity
D3H41_17585	COG2146	nitrite reductase [NAD(P)H] activity
D3H41_17585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_17635	COG2815	serine threonine protein kinase
D3H41_17635	COG0515	serine threonine protein kinase
D3H41_17670	COG0631	protein serine/threonine phosphatase activity
D3H41_17725	COG3501	Rhs element vgr protein
D3H41_17740	COG0420	3'-5' exonuclease activity
D3H41_17745	COG0419	ATPase involved in DNA repair
D3H41_17755	COG3040	lipid binding
D3H41_17765	COG1288	antiporter activity
D3H41_17775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D3H41_17790	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D3H41_17805	COG0583	DNA-binding transcription factor activity
D3H41_17810	COG0277	FAD linked oxidase domain protein
D3H41_17825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3H41_17905	COG5001	Diguanylate cyclase
D3H41_17915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3H41_17920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_17925	COG2146	nitrite reductase [NAD(P)H] activity
D3H41_17930	COG2116	formate transmembrane transporter activity
D3H41_17950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3H41_17985	COG2814	Major facilitator Superfamily
D3H41_17990	COG3118	belongs to the thioredoxin family
D3H41_17995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3H41_18020	COG2271	Major facilitator Superfamily
D3H41_18025	COG3851	Histidine kinase
D3H41_18030	COG2197	response regulator
D3H41_18040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3H41_18045	COG0583	DNA-binding transcription factor activity
D3H41_18055	COG0243	molybdopterin cofactor binding
D3H41_18070	COG0384	phenazine biosynthesis protein PhzF
D3H41_18075	COG1794	racemase activity, acting on amino acids and derivatives
D3H41_18110	COG1328	CTP reductase activity
D3H41_18115	COG0602	queuosine metabolic process
D3H41_18120	COG0534	Mate efflux family protein
D3H41_18125	COG2207	Transcriptional regulator
D3H41_18135	COG0189	ligase activity
D3H41_18135	COG4067	protein conserved in archaea
D3H41_18145	COG3111	PFAM Bacterial OB fold (BOF) protein
D3H41_18155	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3H41_18160	COG4149	molybdate abc transporter
D3H41_18165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3H41_18175	COG2203	Gaf domain
D3H41_18175	COG3706	GGDEF domain
D3H41_18175	COG4251	negative regulation of phosphorylation
D3H41_18175	COG5001	Diguanylate cyclase
D3H41_18180	COG0745	RESPONSE REGULATOR receiver
D3H41_18180	COG3706	GGDEF domain
D3H41_18195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3H41_18200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3H41_18225	COG3140	Belongs to the UPF0181 family
D3H41_18240	COG0583	DNA-binding transcription factor activity
D3H41_18280	COG4128	Pfam Zonular occludens toxin
D3H41_18330	COG0023	Translation Initiation Factor
D3H41_18340	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3H41_18350	COG0045	succinate-CoA ligase (ADP-forming) activity
D3H41_18350	COG1042	CoA-binding domain protein
D3H41_18350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_18355	COG0583	DNA-binding transcription factor activity
D3H41_18375	COG3447	MASE1 domain protein
D3H41_18375	COG5002	protein histidine kinase activity
D3H41_18375	COG5001	Diguanylate cyclase
D3H41_18380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3H41_18385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3H41_18390	COG1984	allophanate hydrolase subunit 2
D3H41_18400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D3H41_18405	COG4181	ATPase activity
D3H41_18415	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3H41_18420	COG3300	MHYT domain
D3H41_18420	COG5001	Diguanylate cyclase
D3H41_18430	COG0484	heat shock protein binding
D3H41_18455	COG4533	DNA binding
D3H41_18465	COG2050	protein possibly involved in aromatic compounds catabolism
D3H41_18480	COG2067	long-chain fatty acid transport protein
D3H41_18485	COG2267	carboxylic ester hydrolase activity
D3H41_18510	COG0737	Belongs to the 5'-nucleotidase family
D3H41_18515	COG3593	DNA synthesis involved in DNA repair
D3H41_18525	COG0583	DNA-binding transcription factor activity
D3H41_18530	COG2116	formate transmembrane transporter activity
D3H41_18535	COG2353	YceI-like domain
D3H41_18540	COG3038	cytochrome b561
D3H41_18560	COG0513	Belongs to the DEAD box helicase family
D3H41_18565	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D3H41_18575	COG0840	transmembrane signaling receptor activity
D3H41_18585	COG0546	phosphoglycolate phosphatase activity
D3H41_18600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_18605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D3H41_18610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3H41_18625	COG2207	Transcriptional regulator
D3H41_18630	COG1979	alcohol dehydrogenase
D3H41_18640	COG1126	abc transporter atp-binding protein
D3H41_18645	COG0765	amino acid transport
D3H41_18650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3H41_18655	COG0765	amino acid transport
D3H41_18660	COG2200	EAL domain
D3H41_18660	COG2203	Gaf domain
D3H41_18660	COG2199	diguanylate cyclase activity
D3H41_18675	COG1609	Transcriptional regulator
D3H41_18680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_18680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3H41_18685	COG1105	Belongs to the carbohydrate kinase PfkB family
D3H41_18690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3H41_18690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D3H41_18690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3H41_18720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3H41_18730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3H41_18735	COG0509	glycine decarboxylation via glycine cleavage system
D3H41_18745	COG0346	lactoylglutathione lyase activity
D3H41_18755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3H41_18760	COG0583	DNA-binding transcription factor activity
D3H41_18765	COG0697	spore germination
D3H41_18770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3H41_18825	COG2176	DNA-directed DNA polymerase activity
D3H41_18870	COG0242	peptide deformylase activity
D3H41_18905	COG2239	Acts as a magnesium transporter
D3H41_18925	COG0346	lactoylglutathione lyase activity
D3H41_18930	COG1902	pentaerythritol trinitrate reductase activity
D3H41_18955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D3H41_18960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3H41_18960	COG0069	glutamate synthase activity
D3H41_18990	COG2076	Multidrug Resistance protein
D3H41_19010	COG2962	Rard protein
D3H41_19025	COG0784	Response regulator, receiver
D3H41_19025	COG0835	chemotaxis
D3H41_19035	COG2197	response regulator
D3H41_19045	COG3706	GGDEF domain
D3H41_19050	COG2197	response regulator
D3H41_19055	COG3300	MHYT domain
D3H41_19055	COG5001	Diguanylate cyclase
D3H41_19060	COG0784	Response regulator, receiver
D3H41_19060	COG2205	protein histidine kinase activity
D3H41_19065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D3H41_19085	COG1214	PFAM Peptidase M22, glycoprotease
D3H41_19085	COG0456	acetyltransferase
D3H41_19095	COG3069	C4-dicarboxylate transmembrane transporter activity
D3H41_19120	COG3111	PFAM Bacterial OB fold (BOF) protein
D3H41_19125	COG1597	lipid kinase activity
D3H41_19130	COG0583	DNA-binding transcription factor activity
D3H41_19165	COG0714	Associated with various cellular activities
D3H41_19170	COG0641	radical SAM
D3H41_19175	COG3119	arylsulfatase activity
D3H41_19185	COG3119	arylsulfatase activity
D3H41_19190	COG0745	RESPONSE REGULATOR receiver
D3H41_19205	COG2198	Histidine kinase
D3H41_19205	COG2205	protein histidine kinase activity
D3H41_19205	COG0784	Response regulator, receiver
D3H41_19210	COG1879	ABC-type sugar transport system periplasmic component
D3H41_19215	COG1803	Methylglyoxal synthase
D3H41_19220	COG0210	DNA helicase
D3H41_19225	COG1289	transmembrane transporter activity
D3H41_19260	COG4771	TonB-dependent receptor
D3H41_19260	COG1629	transport
D3H41_19270	COG0789	Transcriptional regulator
D3H41_19275	COG4604	ABC transporter, ATP-binding protein
D3H41_19280	COG4605	iron ion homeostasis
D3H41_19285	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_19290	COG4607	ABC-type enterochelin transport system periplasmic component
D3H41_19300	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D3H41_19315	COG1609	Transcriptional regulator
D3H41_19320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_19325	COG1879	ABC-type sugar transport system periplasmic component
D3H41_19330	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3H41_19335	COG1129	ABC transporter
D3H41_19340	COG1869	D-ribose catabolic process
D3H41_19345	COG5001	Diguanylate cyclase
D3H41_19405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3H41_19415	COG0784	Response regulator, receiver
D3H41_19415	COG2205	protein histidine kinase activity
D3H41_19430	COG0330	HflC and HflK could
D3H41_19445	COG4175	Glycine betaine
D3H41_19445	COG0517	IMP dehydrogenase activity
D3H41_19450	COG4176	ABC-type proline glycine betaine transport system permease component
D3H41_19465	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_19470	COG1309	transcriptional regulator
D3H41_19475	COG0745	RESPONSE REGULATOR receiver
D3H41_19475	COG3706	GGDEF domain
D3H41_19480	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_19495	COG1024	Enoyl-CoA hydratase
D3H41_19500	COG1960	acyl-CoA dehydrogenase activity
D3H41_19510	COG0183	Belongs to the thiolase family
D3H41_19520	COG1960	acyl-CoA dehydrogenase activity
D3H41_19525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3H41_19550	COG3264	Mechanosensitive ion channel
D3H41_19550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3H41_19560	COG0110	maltose O-acetyltransferase activity
D3H41_19565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_19570	COG1271	oxidase subunit
D3H41_19575	COG1294	oxidase, subunit
D3H41_19590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H41_19600	COG3527	Alpha-acetolactate decarboxylase
D3H41_19615	COG0500	methyltransferase
D3H41_19645	COG1022	Amp-dependent synthetase and ligase
D3H41_19675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3H41_19680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_19680	COG1263	PTS System
D3H41_19685	COG1486	melibiose metabolic process
D3H41_19690	COG2188	Transcriptional regulator
D3H41_19695	COG1320	monovalent cation:proton antiporter activity
D3H41_19700	COG2212	antiporter activity
D3H41_19715	COG1006	Multisubunit Na H antiporter MnhC subunit
D3H41_19720	COG2111	Na H antiporter
D3H41_19720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3H41_19730	COG0589	response to stress
D3H41_19735	COG4221	oxidoreductase activity
D3H41_19740	COG0583	DNA-binding transcription factor activity
D3H41_19750	COG2814	Major facilitator Superfamily
D3H41_19805	COG1522	sequence-specific DNA binding
D3H41_19840	COG0515	serine threonine protein kinase
D3H41_19865	COG3501	Rhs element vgr protein
D3H41_19905	COG0739	heme binding
D3H41_19920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_19965	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D3H41_19975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3H41_19975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3H41_19990	COG4989	oxidoreductase activity
D3H41_20005	COG0038	chloride channel
D3H41_20040	COG2897	thiosulfate sulfurtransferase activity
D3H41_20060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3H41_20065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3H41_20070	COG0840	transmembrane signaling receptor activity
D3H41_20075	COG2814	Major facilitator Superfamily
D3H41_20080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3H41_20095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H41_20105	COG0840	transmembrane signaling receptor activity
D3H41_20125	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3H41_20140	COG2197	response regulator
D3H41_20145	COG3850	Histidine kinase
D3H41_20150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3H41_20160	COG0243	molybdopterin cofactor binding
D3H41_20170	COG3005	denitrification pathway
D3H41_20180	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3H41_20190	COG0183	Belongs to the thiolase family
D3H41_20200	COG1280	lysine exporter protein (LysE YggA)
D3H41_20210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_20215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3H41_20270	COG1846	Transcriptional regulator
D3H41_20275	COG0784	Response regulator, receiver
D3H41_20275	COG2205	protein histidine kinase activity
D3H41_20280	COG1879	ABC-type sugar transport system periplasmic component
D3H41_20290	COG2827	Endonuclease containing a URI domain
D3H41_20295	COG3132	Protein of unknown function, DUF480
D3H41_20315	COG5002	protein histidine kinase activity
D3H41_20315	COG0784	Response regulator, receiver
D3H41_20315	COG2205	protein histidine kinase activity
D3H41_20355	COG0531	amino acid
D3H41_20370	COG2205	protein histidine kinase activity
D3H41_20375	COG0745	RESPONSE REGULATOR receiver
D3H41_20400	COG1566	PFAM secretion protein HlyD family protein
D3H41_20405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3H41_20410	COG2239	Acts as a magnesium transporter
D3H41_20415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D3H41_20420	COG0402	S-adenosylhomocysteine deaminase activity
D3H41_20425	COG1418	mRNA catabolic process
D3H41_20440	COG2814	Major facilitator Superfamily
D3H41_20450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H41_20470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3H41_20485	COG0745	RESPONSE REGULATOR receiver
D3H41_20490	COG2205	protein histidine kinase activity
D3H41_20500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D3H41_20505	COG2194	sulfuric ester hydrolase activity
D3H41_20525	COG4667	esterase of the alpha-beta hydrolase superfamily
D3H41_20530	COG1741	Belongs to the pirin family
D3H41_20535	COG1278	Cold shock
D3H41_20550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3H41_20555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3H41_20555	COG0678	peroxiredoxin activity
D3H41_20565	COG1686	Belongs to the peptidase S11 family
D3H41_20575	COG0625	glutathione transferase activity
D3H41_20585	COG1621	beta-fructofuranosidase activity
D3H41_20590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3H41_20595	COG1263	PTS System
D3H41_20595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_20620	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_20635	COG3746	phosphate-selective porin O and P
D3H41_20655	COG0583	DNA-binding transcription factor activity
D3H41_20660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3H41_20660	COG2207	Transcriptional regulator
D3H41_20665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_20690	COG0513	Belongs to the DEAD box helicase family
D3H41_20700	COG0583	DNA-binding transcription factor activity
D3H41_20715	COG1902	pentaerythritol trinitrate reductase activity
D3H41_20720	COG1063	alcohol dehydrogenase
D3H41_20730	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_20740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_20745	COG0006	proline dipeptidase activity
D3H41_20750	COG3608	succinylglutamate desuccinylase aspartoacylase
D3H41_20755	COG1522	sequence-specific DNA binding
D3H41_20760	COG1012	belongs to the aldehyde dehydrogenase family
D3H41_20765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3H41_20770	COG3122	Protein conserved in bacteria
D3H41_20785	COG0583	DNA-binding transcription factor activity
D3H41_20795	COG0252	asparaginase activity
D3H41_20800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D3H41_20815	COG2197	response regulator
D3H41_20820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3H41_20825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3H41_20845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3H41_20875	COG3842	ATPase activity
D3H41_20895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_20925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3H41_20930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3H41_20965	COG0583	DNA-binding transcription factor activity
D3H41_20975	COG4948	Mandelate Racemase Muconate Lactonizing
D3H41_20985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3H41_21010	COG1342	Belongs to the UPF0251 family
D3H41_21020	COG4176	ABC-type proline glycine betaine transport system permease component
D3H41_21025	COG3448	diguanylate cyclase activity
D3H41_21025	COG4175	Glycine betaine
D3H41_21030	COG3015	lipoprotein NlpE involved in copper resistance
D3H41_21035	COG3713	MltA-interacting MipA family protein
D3H41_21050	COG0583	DNA-binding transcription factor activity
D3H41_21075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D3H41_21085	COG1335	isochorismatase
D3H41_21100	COG1349	DNA-binding transcription factor activity
D3H41_21105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_21105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_21110	COG2070	2-Nitropropane dioxygenase
D3H41_21115	COG0531	amino acid
D3H41_21120	COG4302	ethanolamine ammonia-lyase activity
D3H41_21125	COG4303	Ethanolamine ammonia lyase large subunit
D3H41_21135	COG1309	transcriptional regulator
D3H41_21155	COG1280	lysine exporter protein (LysE YggA)
D3H41_21165	COG0459	protein refolding
D3H41_21170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3H41_21180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3H41_21195	COG1304	FMN binding
D3H41_21220	COG1256	bacterial-type flagellum assembly
D3H41_21220	COG4786	Flagellar basal body rod
D3H41_21230	COG1706	bacterial-type flagellum-dependent cell motility
D3H41_21235	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3H41_21240	COG4786	Flagellar basal body rod
D3H41_21245	COG4787	bacterial-type flagellum-dependent cell motility
D3H41_21250	COG1749	Flagellar hook protein flgE
D3H41_21255	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3H41_21260	COG1558	bacterial-type flagellum-dependent cell motility
D3H41_21265	COG1815	bacterial-type flagellum-dependent cell motility
D3H41_21285	COG0741	lytic transglycosylase activity
D3H41_21290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3H41_21310	COG1760	l-serine dehydratase
D3H41_21325	COG0583	DNA-binding transcription factor activity
D3H41_21335	COG2866	Carboxypeptidase
D3H41_21340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_21350	COG2990	Protein conserved in bacteria
D3H41_21375	COG3842	ATPase activity
D3H41_21380	COG1840	ABC-type Fe3 transport system, periplasmic component
D3H41_21400	COG1609	Transcriptional regulator
D3H41_21430	COG3240	lipase activity
D3H41_21435	COG1309	transcriptional regulator
D3H41_21450	COG1136	(ABC) transporter
D3H41_21450	COG0577	efflux transmembrane transporter activity
D3H41_21455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_21460	COG2067	long-chain fatty acid transport protein
D3H41_21470	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D3H41_21485	COG1011	Hydrolase
D3H41_21525	COG0110	maltose O-acetyltransferase activity
D3H41_21530	COG1765	OsmC-like protein
D3H41_21575	COG1765	OsmC-like protein
D3H41_21580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_21580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3H41_21595	COG3046	protein related to deoxyribodipyrimidine photolyase
D3H41_21600	COG0415	Belongs to the DNA photolyase family
D3H41_21605	COG3706	GGDEF domain
D3H41_21620	COG3706	GGDEF domain
D3H41_21635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3H41_21655	COG3033	Beta-eliminating lyase
D3H41_21665	COG1271	oxidase subunit
D3H41_21670	COG1294	oxidase, subunit
D3H41_21695	COG0579	oxidoreductase
D3H41_21720	COG3706	GGDEF domain
D3H41_21750	COG0583	DNA-binding transcription factor activity
D3H41_21775	COG0189	ligase activity
D3H41_21780	COG4067	protein conserved in archaea
D3H41_21780	COG0189	ligase activity
D3H41_21790	COG1166	arginine decarboxylase activity
D3H41_21795	COG0010	Belongs to the arginase family
D3H41_21800	COG2814	Major facilitator Superfamily
D3H41_21805	COG1770	oligopeptidase
D3H41_21820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3H41_21825	COG1121	(ABC) transporter
D3H41_21830	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3H41_21875	COG0848	biopolymer transport protein
D3H41_21880	COG0811	peptide transport
D3H41_21885	COG0811	peptide transport
D3H41_21905	COG0745	RESPONSE REGULATOR receiver
D3H41_21910	COG0584	glycerophosphoryl diester phosphodiesterase
D3H41_21920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3H41_21985	COG0312	modulator of DNA gyrase
D3H41_21990	COG0312	modulator of DNA gyrase
D3H41_21995	COG0351	phosphomethylpyrimidine kinase
D3H41_22000	COG1116	anion transmembrane transporter activity
D3H41_22005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3H41_22010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3H41_22015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D3H41_22035	COG0243	molybdopterin cofactor binding
D3H41_22040	COG3005	denitrification pathway
D3H41_22045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_22050	COG1028	Short-chain dehydrogenase reductase Sdr
D3H41_22065	COG0456	acetyltransferase
D3H41_22085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_22090	COG1929	Belongs to the glycerate kinase type-1 family
D3H41_22095	COG2610	gluconate transmembrane transporter activity
D3H41_22100	COG3835	regulator
D3H41_22160	COG3047	cAMP biosynthetic process
D3H41_22165	COG1357	PFAM Pentapeptide repeats (8 copies)
D3H41_22195	COG2375	cellular response to nickel ion
D3H41_22200	COG0583	DNA-binding transcription factor activity
D3H41_22205	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D3H41_22210	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3H41_22225	COG2199	diguanylate cyclase activity
D3H41_22235	COG0561	phosphatase activity
D3H41_22240	COG0583	DNA-binding transcription factor activity
D3H41_22255	COG0564	pseudouridine synthase activity
D3H41_22260	COG0534	Mate efflux family protein
D3H41_22265	COG5001	Diguanylate cyclase
D3H41_22275	COG3123	guanosine phosphorylase activity
D3H41_22290	COG0596	Alpha beta hydrolase
D3H41_22315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D3H41_22325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H41_22330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3H41_22330	COG2169	Transcriptional regulator
D3H41_22340	COG2259	Doxx family
D3H41_22345	COG1741	Belongs to the pirin family
D3H41_22365	COG0363	glucosamine-6-phosphate deaminase activity
D3H41_22375	COG0786	glutamate:sodium symporter activity
D3H41_22380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3H41_22385	COG1131	(ABC) transporter
D3H41_22395	COG0786	glutamate:sodium symporter activity
D3H41_22420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3H41_22425	COG3279	Response regulator of the LytR AlgR family
D3H41_22430	COG3275	phosphorelay sensor kinase activity
D3H41_22460	COG0772	Belongs to the SEDS family
D3H41_22485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3H41_22485	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D3H41_22495	COG0444	Belongs to the ABC transporter superfamily
D3H41_22500	COG4608	Belongs to the ABC transporter superfamily
D3H41_22525	COG1444	tRNA N-acetyltransferase activity
D3H41_22545	COG3340	Belongs to the peptidase S51 family
D3H41_22550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_22555	COG1263	PTS System
D3H41_22555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_22560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3H41_22570	COG1737	Transcriptional regulator
D3H41_22580	COG4166	transmembrane transport
D3H41_22625	COG0259	pyridoxamine-phosphate oxidase activity
D3H41_22650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_22690	COG1132	(ABC) transporter
D3H41_22700	COG0513	Belongs to the DEAD box helicase family
D3H41_22705	COG2258	MOSC domain
D3H41_22770	COG3634	alkyl hydroperoxide reductase activity
D3H41_22775	COG0450	alkyl hydroperoxide reductase
D3H41_22780	COG1846	Transcriptional regulator
D3H41_22785	COG1764	response to oxidative stress
D3H41_22820	COG1136	(ABC) transporter
D3H41_22835	COG0463	Glycosyl transferase, family 2
D3H41_22875	COG0745	RESPONSE REGULATOR receiver
D3H41_22885	COG1653	transport
D3H41_22890	COG0019	diaminopimelate decarboxylase activity
D3H41_22895	COG4264	IucA IucC family
D3H41_22920	COG4772	TonB-dependent receptor
D3H41_22925	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D3H41_22930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_22935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_22940	COG1120	ATPase activity
D3H41_22945	COG0840	transmembrane signaling receptor activity
D3H41_22950	COG0612	Peptidase, M16
D3H41_22960	COG0739	heme binding
D3H41_22975	COG2814	Major facilitator Superfamily
D3H41_22985	COG1609	Transcriptional regulator
D3H41_22990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3H41_23015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3H41_23020	COG1609	Transcriptional regulator
D3H41_23070	COG1760	l-serine dehydratase
D3H41_23080	COG4580	involved in the transport of maltose and maltodextrins
D3H41_23105	COG2356	endonuclease I
D3H41_23125	COG1982	Orn Lys Arg decarboxylase major
D3H41_23130	COG0531	amino acid
D3H41_23140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3H41_23145	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D3H41_23150	COG1162	GTPase activity
D3H41_23155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3H41_23155	COG1263	PTS System
D3H41_23160	COG1999	signal sequence binding
D3H41_23175	COG2909	trisaccharide binding
D3H41_23180	COG0058	SHG alpha-glucan phosphorylase activity
D3H41_23185	COG1640	4-alpha-glucanotransferase
D3H41_23190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3H41_23195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3H41_23200	COG0366	Alpha amylase catalytic
D3H41_23215	COG3366	ferrous iron transmembrane transporter activity
D3H41_23220	COG0700	Nucleoside recognition
D3H41_23225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3H41_23230	COG3339	Conserved Protein
D3H41_23245	COG1301	dicarboxylic acid transport
D3H41_23255	COG0583	DNA-binding transcription factor activity
D3H41_23290	COG2095	MarC family integral membrane protein
D3H41_23295	COG4667	esterase of the alpha-beta hydrolase superfamily
D3H41_23300	COG3397	chitin binding
D3H41_23305	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3H41_23310	COG0415	Belongs to the DNA photolyase family
D3H41_23330	COG1686	Belongs to the peptidase S11 family
D3H41_23355	COG0583	DNA-binding transcription factor activity
D3H41_23360	COG4628	conserved protein (DUF2132)
D3H41_23380	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D3H41_23385	COG0628	permease
D3H41_23430	COG2814	Major facilitator Superfamily
D3H41_23445	COG0454	-acetyltransferase
D3H41_23455	COG0745	RESPONSE REGULATOR receiver
D3H41_23460	COG2205	protein histidine kinase activity
D3H41_23480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3H41_23485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3H41_23525	COG1360	Flagellar Motor Protein
D3H41_23530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3H41_23535	COG1191	sigma factor activity
D3H41_23540	COG1580	Controls the rotational direction of flagella during chemotaxis
D3H41_23560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D3H41_23575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3H41_23590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3H41_23600	COG1987	bacterial-type flagellum assembly
D3H41_23625	COG2204	response regulator
D3H41_23640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3H41_23700	COG0346	lactoylglutathione lyase activity
D3H41_23725	COG0745	RESPONSE REGULATOR receiver
D3H41_23750	COG5001	Diguanylate cyclase
D3H41_23750	COG3300	MHYT domain
D3H41_23755	COG0156	8-amino-7-oxononanoate synthase activity
D3H41_23760	COG1063	alcohol dehydrogenase
D3H41_23795	COG0668	transmembrane transport
D3H41_23805	COG1304	FMN binding
D3H41_23810	COG1620	l-lactate permease
D3H41_23815	COG0583	DNA-binding transcription factor activity
D3H41_23820	COG1505	serine-type exopeptidase activity
D3H41_23825	COG4172	Belongs to the ABC transporter superfamily
D3H41_23835	COG1067	ATP-dependent peptidase activity
D3H41_23845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3H41_23865	COG1247	-acetyltransferase
D3H41_23870	COG0437	4 iron, 4 sulfur cluster binding
D3H41_23875	COG0348	domain, Protein
D3H41_23895	COG1122	ATPase activity
D3H41_23900	COG4720	Psort location CytoplasmicMembrane, score
D3H41_23905	COG1566	PFAM secretion protein HlyD family protein
D3H41_23930	COG0813	purine-nucleoside phosphorylase activity
D3H41_23935	COG3272	Protein of unknown function (DUF1722)
D3H41_23940	COG0789	Transcriptional regulator
D3H41_23945	COG0415	Belongs to the DNA photolyase family
D3H41_23950	COG1376	ErfK ybiS ycfS ynhG family protein
D3H41_23950	COG1388	LysM domain
D3H41_23960	COG0513	Belongs to the DEAD box helicase family
D3H41_23965	COG1770	oligopeptidase
D3H41_23970	COG4771	TonB-dependent receptor
D3H41_23995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3H41_24000	COG0573	inorganic phosphate transmembrane transporter activity
D3H41_24005	COG0581	inorganic phosphate transmembrane transporter activity
D3H41_24010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3H41_24030	COG2304	oxidoreductase activity
D3H41_24050	COG0714	Associated with various cellular activities
D3H41_24065	COG2197	response regulator
D3H41_24100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D3H41_24105	COG1120	ATPase activity
D3H41_24110	COG4774	siderophore transport
D3H41_24115	COG1132	(ABC) transporter
D3H41_24130	COG0569	domain protein
D3H41_24135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3H41_24140	COG0583	DNA-binding transcription factor activity
D3H41_24160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3H41_24165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3H41_24175	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D3H41_24180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3H41_24210	COG2084	Dehydrogenase
D3H41_24215	COG0753	catalase activity
D3H41_24225	COG2130	NADP-dependent
D3H41_24230	COG1309	transcriptional regulator
D3H41_24275	COG3206	protein involved in exopolysaccharide biosynthesis
D3H41_24275	COG0489	protein tyrosine kinase activity
D3H41_24290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3H41_24295	COG3842	ATPase activity
D3H41_24305	COG1175	transmembrane transport
D3H41_24310	COG3833	ABC-type maltose transport systems, permease component
D3H41_24340	COG2354	Protein conserved in bacteria
D3H41_24345	COG0418	dihydroorotase activity
D3H41_24355	COG0401	homolog of Blt101
D3H41_24360	COG0633	Ferredoxin
D3H41_24360	COG3217	Mosc domain protein beta barrel domain protein
D3H41_24360	COG0633	Ferredoxin
D3H41_24360	COG3217	Mosc domain protein beta barrel domain protein
D3H41_24370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3H41_24410	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D3H41_24415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3H41_24425	COG0848	biopolymer transport protein
D3H41_24430	COG0811	peptide transport
D3H41_24435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D3H41_24445	COG3721	Heme iron utilization protein
D3H41_24450	COG0748	coenzyme F420 binding
D3H41_24460	COG0835	chemotaxis
D3H41_24460	COG0784	Response regulator, receiver
D3H41_24465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3H41_24470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3H41_24500	COG0534	Mate efflux family protein
D3H41_24505	COG0444	Belongs to the ABC transporter superfamily
D3H41_24510	COG4608	Belongs to the ABC transporter superfamily
D3H41_24515	COG0747	negative chemotaxis
D3H41_24525	COG1349	DNA-binding transcription factor activity
D3H41_24530	COG2084	Dehydrogenase
D3H41_24535	COG3395	kinase activity
D3H41_24540	COG0235	Class ii aldolase
D3H41_24545	COG3622	Belongs to the hyi family
D3H41_24550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3H41_24555	COG2610	gluconate transmembrane transporter activity
D3H41_24575	COG0583	DNA-binding transcription factor activity
D3H41_24580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3H41_24590	COG4934	collagen metabolic process
D3H41_24600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3H41_24605	COG0789	Transcriptional regulator
D3H41_24610	COG0366	Alpha amylase catalytic
D3H41_24630	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3H41_24635	COG0589	response to stress
D3H41_24640	COG0488	(ABC) transporter
D3H41_24645	COG1505	serine-type exopeptidase activity
D3H41_24655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3H41_24675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3H41_24700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3H41_24720	COG3383	formate dehydrogenase (NAD+) activity
D3H41_24730	COG0842	Transport permease protein
D3H41_24735	COG1131	(ABC) transporter
D3H41_24750	COG1881	PFAM PEBP family protein
D3H41_24760	COG0798	PFAM Bile acid sodium symporter
D3H41_24775	COG1733	regulation of RNA biosynthetic process
D3H41_24800	COG4989	oxidoreductase activity
D3H41_24825	COG0814	amino acid
D3H41_24865	COG0739	heme binding
D3H41_24870	COG5001	Diguanylate cyclase
D3H41_24875	COG0583	DNA-binding transcription factor activity
D3H41_24880	COG2814	Major facilitator Superfamily
D3H41_24900	COG0697	spore germination
D3H41_24915	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3H41_24935	COG1280	lysine exporter protein (LysE YggA)
D3H41_24945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3H41_24950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3H41_24960	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D3H41_24965	COG1845	cytochrome c oxidase, subunit III
D3H41_24985	COG1612	heme a metabolic process
D3H41_24990	COG0109	protoheme IX farnesyltransferase activity
D3H41_24995	COG0545	Peptidyl-prolyl cis-trans isomerase
D3H41_25025	COG1278	Cold shock
D3H41_25030	COG3036	rescue of stalled ribosome
D3H41_25035	COG2199	diguanylate cyclase activity
D3H41_25060	COG1538	Outer membrane efflux protein
D3H41_25065	COG2205	protein histidine kinase activity
D3H41_25065	COG0784	Response regulator, receiver
D3H41_25090	COG0840	transmembrane signaling receptor activity
D3H41_25095	COG0783	Belongs to the Dps family
D3H41_25105	COG2133	pyrroloquinoline quinone binding
D3H41_25110	COG1454	alcohol dehydrogenase
D3H41_25115	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D3H41_25135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3H41_25140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3H41_25145	COG3186	Phenylalanine-4-hydroxylase
D3H41_25170	COG3530	Putative quorum-sensing-regulated virulence factor
D3H41_25185	COG2186	Transcriptional regulator
D3H41_25200	COG1279	arginine transmembrane transporter activity