locus-tag	class	description
D0812_00015	COG0592	DNA-directed DNA polymerase activity
D0812_00025	COG0187	DNA topoisomerase II activity
D0812_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
D0812_00035	COG3977	Valine--pyruvate aminotransferase
D0812_00055	COG4964	Belongs to the GSP D family
D0812_00110	COG2205	protein histidine kinase activity
D0812_00120	COG0366	Alpha amylase catalytic
D0812_00135	COG2119	membrane
D0812_00145	COG0425	Belongs to the sulfur carrier protein TusA family
D0812_00160	COG0604	alcohol dehydrogenase
D0812_00165	COG0183	Belongs to the thiolase family
D0812_00175	COG1739	Uncharacterized protein family UPF0029
D0812_00180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_00225	COG2132	Multicopper oxidase
D0812_00245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0812_00250	COG2104	thiamine diphosphate biosynthetic process
D0812_00265	COG0006	proline dipeptidase activity
D0812_00265	COG0006	proline dipeptidase activity
D0812_00275	COG2814	Major facilitator Superfamily
D0812_00295	COG3220	belongs to the UPF0276 family
D0812_00305	COG0210	DNA helicase
D0812_00315	COG0405	Gamma-glutamyltransferase
D0812_00320	COG1280	lysine exporter protein (LysE YggA)
D0812_00330	COG2962	Rard protein
D0812_00335	COG0514	ATP-dependent DNA helicase (RecQ)
D0812_00350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0812_00370	COG3118	belongs to the thioredoxin family
D0812_00375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0812_00385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0812_00390	COG0633	Ferredoxin
D0812_00440	COG2959	enzyme of heme biosynthesis
D0812_00445	COG1587	Uroporphyrinogen-III synthase
D0812_00455	COG3072	Adenylate cyclase
D0812_00470	COG0019	diaminopimelate decarboxylase activity
D0812_00490	COG1011	Hydrolase
D0812_00495	COG2200	EAL domain
D0812_00495	COG3287	FIST C domain
D0812_00495	COG2199	diguanylate cyclase activity
D0812_00515	COG0561	phosphatase activity
D0812_00520	COG2267	carboxylic ester hydrolase activity
D0812_00525	COG1280	lysine exporter protein (LysE YggA)
D0812_00530	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0812_00535	COG0640	Transcriptional regulator
D0812_00540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0812_00595	COG2095	MarC family integral membrane protein
D0812_00605	COG0742	ribosomal rna small subunit methyltransferase
D0812_00610	COG0552	protein localization to endoplasmic reticulum
D0812_00610	COG0552	protein localization to endoplasmic reticulum
D0812_00615	COG2884	Cell division ATP-binding protein ftsE
D0812_00620	COG2177	Part of the ABC transporter FtsEX involved in
D0812_00635	COG0705	Rhomboid family
D0812_00640	COG1580	Controls the rotational direction of flagella during chemotaxis
D0812_00645	COG3161	chorismate lyase activity
D0812_00655	COG2937	Belongs to the GPAT DAPAT family
D0812_00675	COG0534	Mate efflux family protein
D0812_00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0812_00790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0812_00835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0812_00840	COG0250	Participates in transcription elongation, termination and antitermination
D0812_00845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0812_00855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0812_00860	COG0222	ribosome binding
D0812_00880	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D0812_00885	COG2816	NAD+ diphosphatase activity
D0812_00895	COG1573	uracil-dna glycosylase
D0812_00905	COG3068	Protein conserved in bacteria
D0812_00910	COG1253	flavin adenine dinucleotide binding
D0812_00925	COG0151	Belongs to the GarS family
D0812_00935	COG0789	Transcriptional regulator
D0812_00940	COG3710	Transcriptional regulator
D0812_00950	COG0531	amino acid
D0812_00955	COG1982	Orn Lys Arg decarboxylase major
D0812_01000	COG5001	Diguanylate cyclase
D0812_01000	COG3300	MHYT domain
D0812_01005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0812_01010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0812_01025	COG0439	Biotin carboxylase
D0812_01030	COG0511	ligase activity, forming carbon-carbon bonds
D0812_01035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0812_01040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0812_01055	COG2814	Major facilitator Superfamily
D0812_01060	COG2198	Histidine kinase
D0812_01060	COG0784	Response regulator, receiver
D0812_01060	COG2205	protein histidine kinase activity
D0812_01080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_01090	COG2095	MarC family integral membrane protein
D0812_01100	COG4232	protein-disulfide reductase activity
D0812_01105	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0812_01110	COG1027	Aspartate ammonia-lyase
D0812_01115	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0812_01120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0812_01130	COG2205	protein histidine kinase activity
D0812_01135	COG0745	RESPONSE REGULATOR receiver
D0812_01140	COG3678	ATP-independent chaperone mediated protein folding
D0812_01145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D0812_01155	COG0534	Mate efflux family protein
D0812_01180	COG1509	lysine 2,3-aminomutase activity
D0812_01185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0812_01210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0812_01215	COG1053	succinate dehydrogenase
D0812_01240	COG4942	peptidase
D0812_01245	COG1045	serine acetyltransferase
D0812_01255	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D0812_01260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0812_01265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D0812_01275	COG0840	transmembrane signaling receptor activity
D0812_01280	COG0471	metal ion transport
D0812_01295	COG1162	GTPase activity
D0812_01300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D0812_01375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0812_01380	COG0802	atpase or kinase
D0812_01385	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0812_01390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0812_01405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0812_01410	COG0330	HflC and HflK could
D0812_01415	COG0330	HflC and HflK could
D0812_01420	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D0812_01425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0812_01435	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0812_01440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0812_01440	COG1017	nitric oxide dioxygenase activity
D0812_01450	COG0557	exoribonuclease II activity
D0812_01455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0812_01460	COG0546	phosphoglycolate phosphatase activity
D0812_01475	COG0512	Glutamine amidotransferase of anthranilate synthase
D0812_01480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0812_01500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_01505	COG3954	Phosphoribulokinase
D0812_01515	COG0429	hydrolase of the alpha beta-hydrolase fold
D0812_01525	COG0488	(ABC) transporter
D0812_01535	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_01550	COG1047	Peptidyl-prolyl cis-trans
D0812_01560	COG1446	asparaginase
D0812_01575	COG0545	Peptidyl-prolyl cis-trans isomerase
D0812_01580	COG2964	Protein conserved in bacteria
D0812_01585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D0812_01590	COG2923	Belongs to the DsrF TusC family
D0812_01595	COG2168	tRNA wobble position uridine thiolation
D0812_01610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0812_01620	COG2906	2 iron, 2 sulfur cluster binding
D0812_01630	COG0281	malic enzyme
D0812_01640	COG0626	cystathionine gamma-synthase activity
D0812_01645	COG0460	homoserine dehydrogenase
D0812_01645	COG0527	aspartate kinase activity
D0812_01650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0812_01660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0812_01670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0812_01685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0812_01685	COG0165	Argininosuccinate lyase
D0812_01700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0812_01705	COG0678	peroxiredoxin activity
D0812_01705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0812_01715	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0812_01760	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0812_01765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0812_01775	COG2965	DNA replication, synthesis of RNA primer
D0812_01795	COG0305	Participates in initiation and elongation during chromosome replication
D0812_01800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0812_01810	COG0432	Pfam Uncharacterised protein family UPF0047
D0812_01825	COG0735	belongs to the Fur family
D0812_01830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0812_01850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0812_01920	COG1410	methionine synthase
D0812_01920	COG0646	methionine synthase
D0812_01925	COG0527	aspartate kinase activity
D0812_01935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0812_01945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0812_01960	COG0629	single-stranded DNA binding
D0812_01965	COG2199	diguanylate cyclase activity
D0812_01965	COG2200	EAL domain
D0812_01990	COG3409	Peptidoglycan-binding domain 1 protein
D0812_01990	COG3267	Type II secretory pathway component ExeA
D0812_02000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_02005	COG1459	type II secretion system
D0812_02055	COG1077	Cell shape determining protein MreB Mrl
D0812_02060	COG1792	Involved in formation and maintenance of cell shape
D0812_02065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0812_02070	COG0424	maF-like protein
D0812_02075	COG1530	ribonuclease E activity
D0812_02080	COG3164	Protein of unknown function
D0812_02085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0812_02090	COG0312	modulator of DNA gyrase
D0812_02095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0812_02110	COG0564	pseudouridine synthase activity
D0812_02115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0812_02120	COG3028	Belongs to the UPF0307 family
D0812_02125	COG0312	modulator of DNA gyrase
D0812_02130	COG2239	Acts as a magnesium transporter
D0812_02135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_02145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_02150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0812_02160	COG1137	ATPase activity
D0812_02165	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D0812_02175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0812_02175	COG0517	IMP dehydrogenase activity
D0812_02185	COG1127	ABC transporter
D0812_02190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0812_02195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0812_02200	COG2854	intermembrane phospholipid transfer
D0812_02210	COG5007	Belongs to the BolA IbaG family
D0812_02220	COG0204	Acyl-transferase
D0812_02225	COG0251	oxidation-reduction process
D0812_02275	COG0525	valine-tRNA ligase activity
D0812_02280	COG2927	DNA polymerase III (CHI subunit)
D0812_02290	COG0795	lipopolysaccharide-transporting ATPase activity
D0812_02295	COG0795	lipopolysaccharide-transporting ATPase activity
D0812_02305	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_02315	COG0726	polysaccharide deacetylase
D0812_02320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0812_02330	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0812_02335	COG1486	melibiose metabolic process
D0812_02350	COG3437	response regulator, receiver
D0812_02400	COG1012	belongs to the aldehyde dehydrogenase family
D0812_02500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0812_02505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0812_02520	COG0762	integral membrane protein
D0812_02525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0812_02530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0812_02545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0812_02550	COG1678	Uncharacterized ACR, COG1678
D0812_02555	COG0189	ligase activity
D0812_02560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0812_02565	COG2356	endonuclease I
D0812_02580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0812_02585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0812_02605	COG0191	fructose-bisphosphate aldolase activity
D0812_02610	COG0668	transmembrane transport
D0812_02625	COG0583	DNA-binding transcription factor activity
D0812_02635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0812_02645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0812_02655	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D0812_02670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0812_02675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0812_02695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0812_02705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0812_02715	COG1595	DNA-templated transcription, initiation
D0812_02725	COG3026	antisigma factor binding
D0812_02730	COG3086	response to oxidative stress
D0812_02740	COG0681	Belongs to the peptidase S26 family
D0812_02750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0812_02755	COG1381	Involved in DNA repair and RecF pathway recombination
D0812_02760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0812_02785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0812_02790	COG3956	TIGRFAM MazG family protein
D0812_02800	COG0148	phosphopyruvate hydratase activity
D0812_02810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0812_02840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0812_02850	COG1546	Belongs to the CinA family
D0812_02855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0812_02870	COG0527	aspartate kinase activity
D0812_02965	COG5016	pyruvate
D0812_02965	COG0511	ligase activity, forming carbon-carbon bonds
D0812_02970	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D0812_02980	COG1238	metal cluster binding
D0812_02985	COG0612	Peptidase, M16
D0812_03005	COG4536	flavin adenine dinucleotide binding
D0812_03010	COG4137	Cytochrome C assembly protein
D0812_03015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0812_03020	COG0228	four-way junction DNA binding
D0812_03035	COG0335	large ribosomal subunit rRNA binding
D0812_03040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D0812_03045	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D0812_03050	COG0237	dephospho-CoA kinase activity
D0812_03060	COG1459	type II secretion system
D0812_03065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_03090	COG2186	Transcriptional regulator
D0812_03095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0812_03100	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0812_03105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0812_03120	COG0288	reversible hydration of carbon dioxide
D0812_03125	COG0659	secondary active sulfate transmembrane transporter activity
D0812_03130	COG1131	(ABC) transporter
D0812_03135	COG0842	Transport permease protein
D0812_03140	COG1560	Kdo2-lipid A biosynthetic process
D0812_03155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0812_03165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0812_03170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0812_03180	COG1643	Atp-dependent helicase
D0812_03185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0812_03190	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0812_03195	COG1049	propionate catabolic process, 2-methylcitrate cycle
D0812_03210	COG0004	ammonium transporteR
D0812_03215	COG1840	ABC-type Fe3 transport system, periplasmic component
D0812_03230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0812_03245	COG2971	BadF BadG BcrA BcrD
D0812_03255	COG4608	Belongs to the ABC transporter superfamily
D0812_03260	COG0444	Belongs to the ABC transporter superfamily
D0812_03265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0812_03275	COG0747	negative chemotaxis
D0812_03295	COG0628	permease
D0812_03320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_03325	COG0739	heme binding
D0812_03330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0812_03340	COG2027	D-alanyl-D-alanine carboxypeptidase
D0812_03345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0812_03350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_03355	COG1534	Rna-binding protein
D0812_03365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0812_03370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0812_03380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0812_03400	COG0195	Participates in both transcription termination and antitermination
D0812_03420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0812_03440	COG0534	Mate efflux family protein
D0812_03465	COG3153	acetyltransferase
D0812_03485	COG3706	GGDEF domain
D0812_03495	COG0084	hydrolase, TatD family'
D0812_03500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0812_03510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D0812_03520	COG0813	purine-nucleoside phosphorylase activity
D0812_03530	COG0560	Phosphoserine phosphatase
D0812_03540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0812_03545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0812_03550	COG0583	DNA-binding transcription factor activity
D0812_03585	COG1022	Amp-dependent synthetase and ligase
D0812_03590	COG0741	lytic transglycosylase activity
D0812_03615	COG4964	Belongs to the GSP D family
D0812_03675	COG0583	DNA-binding transcription factor activity
D0812_03680	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0812_03680	COG3408	Glycogen debranching enzyme
D0812_03690	COG0531	amino acid
D0812_03695	COG2731	YhcH YjgK YiaL family protein
D0812_03700	COG3250	beta-galactosidase activity
D0812_03705	COG1609	Transcriptional regulator
D0812_03710	COG0768	penicillin binding
D0812_03715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_03720	COG1085	galactose-1-phosphate uridylyltransferase
D0812_03730	COG2017	converts alpha-aldose to the beta-anomer
D0812_03740	COG1609	Transcriptional regulator
D0812_03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_03745	COG1263	PTS System
D0812_03755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0812_03775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0812_03780	COG1349	DNA-binding transcription factor activity
D0812_03790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0812_03800	COG2271	Major facilitator Superfamily
D0812_03805	COG0584	glycerophosphoryl diester phosphodiesterase
D0812_03820	COG2171	N-acyltransferase activity
D0812_03835	COG3141	response to X-ray
D0812_03855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0812_03860	COG1074	ATP-dependent DNA helicase activity
D0812_03865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0812_03880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0812_03880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0812_03895	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0812_03900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0812_03905	COG2166	iron-sulfur cluster assembly
D0812_03910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0812_03915	COG0693	protein deglycase activity
D0812_03920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0812_03925	COG3248	Nucleoside-binding outer membrane protein
D0812_03945	COG1595	DNA-templated transcription, initiation
D0812_03975	COG0271	Belongs to the BolA IbaG family
D0812_04000	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0812_04010	COG1477	protein flavinylation
D0812_04020	COG0745	RESPONSE REGULATOR receiver
D0812_04020	COG3706	GGDEF domain
D0812_04025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0812_04030	COG0514	ATP-dependent DNA helicase (RecQ)
D0812_04035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_04050	COG0733	neurotransmitter:sodium symporter activity
D0812_04075	COG1720	tRNA m6t6A37 methyltransferase activity
D0812_04090	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0812_04125	COG3098	single-species biofilm formation
D0812_04130	COG0564	pseudouridine synthase activity
D0812_04145	COG0024	Methionine aminopeptidase
D0812_04170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0812_04175	COG0575	Belongs to the CDS family
D0812_04185	COG0750	zinc metalloprotease
D0812_04195	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D0812_04200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0812_04225	COG0587	DNA-directed DNA polymerase activity
D0812_04245	COG0347	Belongs to the P(II) protein family
D0812_04260	COG1388	LysM domain
D0812_04260	COG0741	lytic transglycosylase activity
D0812_04270	COG2226	methyltransferase
D0812_04280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0812_04300	COG1960	acyl-CoA dehydrogenase activity
D0812_04305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0812_04310	COG0121	glutamine amidotransferase
D0812_04315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0812_04320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0812_04325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0812_04330	COG2233	PERMEase
D0812_04350	COG1393	Belongs to the ArsC family
D0812_04355	COG4783	chaperone-mediated protein folding
D0812_04370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0812_04375	COG2716	regulation of RNA biosynthetic process
D0812_04380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0812_04405	COG1393	Belongs to the ArsC family
D0812_04430	COG2837	iron assimilation
D0812_04435	COG2169	Transcriptional regulator
D0812_04440	COG1486	melibiose metabolic process
D0812_04455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_04465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_04470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_04475	COG1334	flagellar protein FlaG
D0812_04480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0812_04490	COG1516	flagellar protein fliS
D0812_04495	COG2204	response regulator
D0812_04500	COG4191	Histidine kinase
D0812_04505	COG2204	response regulator
D0812_04510	COG1677	Flagellar hook-basal body complex protein FliE
D0812_04520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0812_04575	COG1987	bacterial-type flagellum assembly
D0812_04580	COG1684	flagellar biosynthetic protein fliR
D0812_04600	COG0455	bacterial-type flagellum organization
D0812_04615	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0812_04620	COG0643	Histidine kinase
D0812_04620	COG2198	Histidine kinase
D0812_04625	COG2201	protein-glutamate methylesterase activity
D0812_04630	COG1192	Involved in chromosome partitioning
D0812_04640	COG0835	chemotaxis
D0812_04650	COG4133	protoheme IX ABC transporter activity
D0812_04655	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0812_04660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0812_04675	COG1138	Cytochrome C-type biogenesis protein
D0812_04680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0812_04690	COG3088	subunit of a heme lyase
D0812_04690	COG4235	cytochrome complex assembly
D0812_04695	COG2853	Lipoprotein
D0812_04700	COG2067	long-chain fatty acid transport protein
D0812_04705	COG2067	long-chain fatty acid transport protein
D0812_04720	COG0183	Belongs to the thiolase family
D0812_04735	COG2062	phosphohistidine phosphatase, SixA
D0812_04740	COG2840	Smr protein MutS2
D0812_04745	COG2890	protein-(glutamine-N5) methyltransferase activity
D0812_04755	COG2860	membrane
D0812_04760	COG3101	peptidyl-lysine hydroxylation
D0812_04785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0812_04795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0812_04800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0812_04825	COG0285	dihydrofolate synthase activity
D0812_04830	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D0812_04835	COG1286	toxin biosynthetic process
D0812_04840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0812_04845	COG0583	DNA-binding transcription factor activity
D0812_04850	COG0745	RESPONSE REGULATOR receiver
D0812_04860	COG2832	Protein of unknown function (DUF454)
D0812_04870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0812_04880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0812_04885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0812_04890	COG0814	amino acid
D0812_04895	COG0251	oxidation-reduction process
D0812_04905	COG2964	Protein conserved in bacteria
D0812_04920	COG2983	Belongs to the UPF0260 family
D0812_04925	COG2261	transglycosylase associated protein
D0812_04930	COG2985	domain, Protein
D0812_04935	COG0076	glutamate decarboxylase activity
D0812_04940	COG0668	transmembrane transport
D0812_04950	COG0346	lactoylglutathione lyase activity
D0812_04960	COG1785	Belongs to the alkaline phosphatase family
D0812_04975	COG2226	methyltransferase
D0812_05000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0812_05005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_05015	COG3139	Protein of unknown function (DUF1315)
D0812_05020	COG0252	asparaginase activity
D0812_05025	COG0616	signal peptide processing
D0812_05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0812_05030	COG1902	pentaerythritol trinitrate reductase activity
D0812_05035	COG0778	Nitroreductase
D0812_05040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0812_05055	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0812_05060	COG4269	membrane
D0812_05075	COG3083	sulfuric ester hydrolase activity
D0812_05100	COG1757	Na H antiporter
D0812_05105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0812_05115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_05120	COG2095	MarC family integral membrane protein
D0812_05125	COG1454	alcohol dehydrogenase
D0812_05125	COG1012	belongs to the aldehyde dehydrogenase family
D0812_05145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0812_05150	COG4974	Belongs to the 'phage' integrase family
D0812_05205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0812_05205	COG2885	chlorophyll binding
D0812_05215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0812_05215	COG2885	chlorophyll binding
D0812_05260	COG2003	Belongs to the UPF0758 family
D0812_05330	COG3504	Conjugal transfer protein
D0812_05355	COG3451	type IV secretory pathway VirB4
D0812_05390	COG2056	Na+-H+ antiporter family
D0812_05400	COG2885	chlorophyll binding
D0812_05410	COG0346	lactoylglutathione lyase activity
D0812_05455	COG3501	Rhs element vgr protein
D0812_05470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0812_05470	COG0515	serine threonine protein kinase
D0812_05485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0812_05515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0812_05520	COG4660	Part of a membrane complex involved in electron transport
D0812_05525	COG4659	FMN binding
D0812_05530	COG4658	electron transport chain
D0812_05535	COG4656	Part of a membrane complex involved in electron transport
D0812_05545	COG4657	Part of a membrane complex involved in electron transport
D0812_05550	COG1882	Formate acetyltransferase
D0812_05565	COG0556	nucleotide-excision repair
D0812_05580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0812_05585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0812_05590	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0812_05600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0812_05605	COG0314	molybdopterin synthase activity
D0812_05615	COG0601	transmembrane transport
D0812_05620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0812_05625	COG0444	Belongs to the ABC transporter superfamily
D0812_05635	COG0435	Glutathione S-transferase
D0812_05640	COG3174	membrane
D0812_05650	COG0280	phosphate acetyltransferase
D0812_05650	COG0857	belongs to the CobB CobQ family
D0812_05675	COG4120	Belongs to the binding-protein-dependent transport system permease family
D0812_05680	COG1122	ATPase activity
D0812_05685	COG0366	Alpha amylase catalytic
D0812_05695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0812_05700	COG3012	SEC-C Motif Domain Protein
D0812_05700	COG3318	Belongs to the UPF0149 family
D0812_05705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0812_05715	COG2186	Transcriptional regulator
D0812_05760	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D0812_05765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0812_05770	COG0659	secondary active sulfate transmembrane transporter activity
D0812_05780	COG1530	ribonuclease E activity
D0812_05785	COG0564	pseudouridine synthase activity
D0812_05790	COG0424	maF-like protein
D0812_05795	COG1399	metal-binding, possibly nucleic acid-binding protein
D0812_05810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0812_05840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0812_05855	COG0084	hydrolase, TatD family'
D0812_05860	COG1263	PTS System
D0812_05860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_05875	COG0733	neurotransmitter:sodium symporter activity
D0812_05890	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_05900	COG1940	carbohydrate kinase activity
D0812_05905	COG0784	Response regulator, receiver
D0812_05905	COG0835	chemotaxis
D0812_05925	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_05930	COG0616	signal peptide processing
D0812_05940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0812_05945	COG0539	negative regulation of cytoplasmic translation
D0812_05955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D0812_05960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0812_05970	COG4166	transmembrane transport
D0812_06030	COG3119	arylsulfatase activity
D0812_06035	COG1309	transcriptional regulator
D0812_06040	COG3009	Protein conserved in bacteria
D0812_06045	COG3008	intermembrane lipid transfer
D0812_06045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0812_06050	COG2995	paraquat-inducible protein a
D0812_06055	COG1609	Transcriptional regulator
D0812_06060	COG3258	Cytochrome c
D0812_06065	COG2863	cytochrome
D0812_06095	COG3250	beta-galactosidase activity
D0812_06105	COG4580	involved in the transport of maltose and maltodextrins
D0812_06115	COG2211	Major facilitator Superfamily
D0812_06120	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_06135	COG4232	protein-disulfide reductase activity
D0812_06140	COG3118	belongs to the thioredoxin family
D0812_06150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0812_06160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_06170	COG3153	acetyltransferase
D0812_06210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_06220	COG0577	efflux transmembrane transporter activity
D0812_06220	COG1136	(ABC) transporter
D0812_06225	COG0577	efflux transmembrane transporter activity
D0812_06225	COG1136	(ABC) transporter
D0812_06230	COG0577	efflux transmembrane transporter activity
D0812_06230	COG1136	(ABC) transporter
D0812_06240	COG2176	DNA-directed DNA polymerase activity
D0812_06255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0812_06310	COG5002	protein histidine kinase activity
D0812_06310	COG3850	Histidine kinase
D0812_06315	COG0745	RESPONSE REGULATOR receiver
D0812_06320	COG0463	Glycosyl transferase, family 2
D0812_06325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0812_06335	COG0840	transmembrane signaling receptor activity
D0812_06340	COG2964	Protein conserved in bacteria
D0812_06355	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0812_06375	COG1032	radical SAM domain protein
D0812_06380	COG5001	Diguanylate cyclase
D0812_06380	COG3706	GGDEF domain
D0812_06380	COG2203	Gaf domain
D0812_06380	COG4251	negative regulation of phosphorylation
D0812_06395	COG0583	DNA-binding transcription factor activity
D0812_06410	COG2350	Protein conserved in bacteria
D0812_06415	COG1607	acyl-coa hydrolase
D0812_06440	COG1301	dicarboxylic acid transport
D0812_06445	COG0159	tryptophan synthase activity
D0812_06455	COG0135	phosphoribosylanthranilate isomerase activity
D0812_06455	COG0134	indole-3-glycerol-phosphate synthase activity
D0812_06465	COG0512	Glutamine amidotransferase of anthranilate synthase
D0812_06470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0812_06480	COG0613	PHP domain protein
D0812_06485	COG0009	L-threonylcarbamoyladenylate synthase
D0812_06495	COG1187	pseudouridine synthase activity
D0812_06515	COG0417	DNA replication proofreading
D0812_06520	COG2197	response regulator
D0812_06525	COG0322	excinuclease ABC activity
D0812_06565	COG0019	diaminopimelate decarboxylase activity
D0812_06590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_06595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_06605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0812_06625	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D0812_06635	COG0437	4 iron, 4 sulfur cluster binding
D0812_06640	COG3301	Polysulphide reductase, NrfD
D0812_06645	COG1138	Cytochrome C-type biogenesis protein
D0812_06655	COG4235	cytochrome complex assembly
D0812_06655	COG3088	subunit of a heme lyase
D0812_06665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0812_06690	COG2989	Protein conserved in bacteria
D0812_06695	COG3108	Peptidase M15
D0812_06700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0812_06715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0812_06740	COG1846	Transcriptional regulator
D0812_06745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_06750	COG0840	transmembrane signaling receptor activity
D0812_06770	COG1448	Aminotransferase
D0812_06775	COG3437	response regulator, receiver
D0812_06775	COG2770	Histidine kinase
D0812_06780	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_06790	COG1609	Transcriptional regulator
D0812_06805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_06820	COG0017	Asparaginyl-tRNA synthetase
D0812_06830	COG0720	synthase
D0812_06835	COG2197	response regulator
D0812_06845	COG3300	MHYT domain
D0812_06845	COG5001	Diguanylate cyclase
D0812_06850	COG1760	l-serine dehydratase
D0812_06855	COG0814	amino acid
D0812_06870	COG0784	Response regulator, receiver
D0812_06870	COG2205	protein histidine kinase activity
D0812_06875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0812_06890	COG3106	COG3106 Predicted ATPase
D0812_06905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_07115	COG2801	Transposase and inactivated derivatives
D0812_07325	COG1403	HNH endonuclease
D0812_07425	COG2801	Transposase and inactivated derivatives
D0812_07500	COG1733	regulation of RNA biosynthetic process
D0812_07510	COG3340	Belongs to the peptidase S51 family
D0812_07530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_07555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0812_07560	COG1609	Transcriptional regulator
D0812_07600	COG0456	acetyltransferase
D0812_07605	COG0471	metal ion transport
D0812_07610	COG4191	Histidine kinase
D0812_07610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_07620	COG3300	MHYT domain
D0812_07620	COG5001	Diguanylate cyclase
D0812_07630	COG1280	lysine exporter protein (LysE YggA)
D0812_07635	COG1328	CTP reductase activity
D0812_07640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0812_07650	COG0861	Integral membrane protein TerC family
D0812_07660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_07670	COG3706	GGDEF domain
D0812_07685	COG0814	amino acid
D0812_07705	COG1132	(ABC) transporter
D0812_07710	COG1132	(ABC) transporter
D0812_07725	COG0583	DNA-binding transcription factor activity
D0812_07750	COG0443	Heat shock 70 kDa protein
D0812_07755	COG0443	Heat shock 70 kDa protein
D0812_07765	COG3706	GGDEF domain
D0812_07790	COG3227	Zinc metalloprotease (Elastase)
D0812_07800	COG0243	molybdopterin cofactor binding
D0812_07805	COG0437	4 iron, 4 sulfur cluster binding
D0812_07810	COG3302	dmso reductase anchor subunit
D0812_07825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0812_07830	COG1643	Atp-dependent helicase
D0812_07855	COG3063	Type IV pilus biogenesis stability protein PilW
D0812_07890	COG0531	amino acid
D0812_07895	COG1280	lysine exporter protein (LysE YggA)
D0812_07900	COG0583	DNA-binding transcription factor activity
D0812_07905	COG0702	epimerase
D0812_07910	COG0583	DNA-binding transcription factor activity
D0812_07915	COG1560	Kdo2-lipid A biosynthetic process
D0812_07930	COG1846	Transcriptional regulator
D0812_07945	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D0812_07950	COG1280	lysine exporter protein (LysE YggA)
D0812_07980	COG1115	amino acid carrier protein
D0812_08035	COG0583	DNA-binding transcription factor activity
D0812_08040	COG1368	sulfuric ester hydrolase activity
D0812_08045	COG0215	cysteine-tRNA ligase activity
D0812_08050	COG0534	Mate efflux family protein
D0812_08055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D0812_08065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_08070	COG0456	acetyltransferase
D0812_08075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0812_08080	COG0662	Cupin 2, conserved barrel domain protein
D0812_08085	COG0527	aspartate kinase activity
D0812_08100	COG0583	DNA-binding transcription factor activity
D0812_08105	COG1858	cytochrome C peroxidase
D0812_08110	COG1404	Belongs to the peptidase S8 family
D0812_08115	COG0583	DNA-binding transcription factor activity
D0812_08135	COG2169	Transcriptional regulator
D0812_08140	COG0697	spore germination
D0812_08145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0812_08150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D0812_08160	COG0583	DNA-binding transcription factor activity
D0812_08165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_08185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_08200	COG3423	Transcriptional regulator
D0812_08210	COG2842	Transposition protein
D0812_08265	COG3012	SEC-C Motif Domain Protein
D0812_08480	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_08515	COG2986	histidine ammonia-lyase
D0812_08520	COG1216	Glycosyl transferase, family 2
D0812_08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0812_08545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0812_08590	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_08600	COG1169	isochorismate synthase
D0812_08605	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0812_08610	COG1535	isochorismatase
D0812_08610	COG3433	isochorismatase activity
D0812_08615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0812_08615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0812_08630	COG4771	TonB-dependent receptor
D0812_08635	COG1253	flavin adenine dinucleotide binding
D0812_08640	COG0513	Belongs to the DEAD box helicase family
D0812_08645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_08650	COG0569	domain protein
D0812_08655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_08675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0812_08680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0812_08685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0812_08720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0812_08725	COG0776	regulation of translation
D0812_08730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0812_08735	COG1555	photosystem II stabilization
D0812_08755	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D0812_08760	COG0436	Aminotransferase
D0812_08765	COG1169	isochorismate synthase
D0812_08775	COG0596	Alpha beta hydrolase
D0812_08780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D0812_08785	COG1441	menaquinone biosynthetic process
D0812_08795	COG1263	PTS System
D0812_08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_08795	COG2190	(PTS) system
D0812_08800	COG0583	DNA-binding transcription factor activity
D0812_08810	COG2855	membrane
D0812_08865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_08885	COG1522	sequence-specific DNA binding
D0812_08895	COG1946	Acyl-CoA thioesterase
D0812_08900	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D0812_08915	COG2199	diguanylate cyclase activity
D0812_08945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D0812_08965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0812_08970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0812_08975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0812_08980	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D0812_08985	COG0516	GMP reductase activity
D0812_08985	COG0517	IMP dehydrogenase activity
D0812_09010	COG0840	transmembrane signaling receptor activity
D0812_09015	COG0537	adenosine 5'-monophosphoramidase activity
D0812_09045	COG1252	NADH dehydrogenase
D0812_09060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0812_09070	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0812_09075	COG1136	(ABC) transporter
D0812_09080	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0812_09095	COG1132	(ABC) transporter
D0812_09115	COG2719	SpoVR family
D0812_09120	COG2718	Belongs to the UPF0229 family
D0812_09125	COG2766	serine protein kinase
D0812_09145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0812_09155	COG1882	Formate acetyltransferase
D0812_09180	COG4215	(ABC) transporter
D0812_09195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_09205	COG0708	Exodeoxyribonuclease III
D0812_09210	COG0840	transmembrane signaling receptor activity
D0812_09220	COG3923	Primosomal replication protein n
D0812_09225	COG0730	response to heat
D0812_09230	COG1199	ATP-dependent helicase activity
D0812_09240	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0812_09245	COG1187	pseudouridine synthase activity
D0812_09255	COG1278	Cold shock
D0812_09265	COG0542	response to heat
D0812_09270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0812_09300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0812_09305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0812_09310	COG0297	glycogen (starch) synthase activity
D0812_09330	COG3070	regulator of competence-specific genes
D0812_09345	COG0745	RESPONSE REGULATOR receiver
D0812_09350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0812_09355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0812_09365	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D0812_09370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0812_09385	COG0318	PFAM AMP-dependent synthetase and ligase
D0812_09410	COG4067	protein conserved in archaea
D0812_09410	COG0189	ligase activity
D0812_09430	COG1801	Protein of unknown function DUF72
D0812_09445	COG0840	transmembrane signaling receptor activity
D0812_09450	COG0632	four-way junction helicase activity
D0812_09460	COG1271	oxidase subunit
D0812_09465	COG1294	oxidase, subunit
D0812_09470	COG4890	Cyd operon protein YbgT
D0812_09480	COG0824	Thioesterase
D0812_09485	COG0811	peptide transport
D0812_09500	COG0823	Involved in the tonB-independent uptake of proteins
D0812_09505	COG2885	chlorophyll binding
D0812_09510	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D0812_09525	COG3766	membrane
D0812_09535	COG0754	glutathionylspermidine amidase activity
D0812_09545	COG5002	protein histidine kinase activity
D0812_09545	COG0784	Response regulator, receiver
D0812_09575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D0812_09620	COG0602	queuosine metabolic process
D0812_09625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D0812_09630	COG0302	gtp cyclohydrolase
D0812_09635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0812_09640	COG0514	ATP-dependent DNA helicase (RecQ)
D0812_09700	COG3119	arylsulfatase activity
D0812_09715	COG1263	PTS System
D0812_09715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_09720	COG2723	6-phospho-beta-galactosidase activity
D0812_09725	COG2824	Alkylphosphonate utilization operon protein PhnA
D0812_09730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_09755	COG0534	Mate efflux family protein
D0812_09760	COG0444	Belongs to the ABC transporter superfamily
D0812_09765	COG4608	Belongs to the ABC transporter superfamily
D0812_09770	COG0747	negative chemotaxis
D0812_09800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_09805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_09815	COG2186	Transcriptional regulator
D0812_09830	COG1288	antiporter activity
D0812_09850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_09855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_09860	COG1120	ATPase activity
D0812_09880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_09895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D0812_09905	COG2176	DNA-directed DNA polymerase activity
D0812_09910	COG0517	IMP dehydrogenase activity
D0812_09915	COG2186	Transcriptional regulator
D0812_09920	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_09925	COG2186	Transcriptional regulator
D0812_09950	COG1904	glucuronate isomerase
D0812_09955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0812_09970	COG1917	Cupin 2, conserved barrel domain protein
D0812_09975	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_09995	COG0701	Predicted permease
D0812_10020	COG3568	Endonuclease Exonuclease Phosphatase
D0812_10030	COG4934	collagen metabolic process
D0812_10045	COG3181	Tripartite tricarboxylate transporter family receptor
D0812_10055	COG0402	S-adenosylhomocysteine deaminase activity
D0812_10085	COG1917	Cupin 2, conserved barrel domain protein
D0812_10090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_10095	COG0800	Aldolase
D0812_10120	COG0583	DNA-binding transcription factor activity
D0812_10130	COG0686	Belongs to the AlaDH PNT family
D0812_10140	COG1674	ftsk spoiiie
D0812_10150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0812_10165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0812_10170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0812_10210	COG0300	oxidoreductase activity
D0812_10225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0812_10235	COG2268	Band 7 protein
D0812_10245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0812_10265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_10275	COG1757	Na H antiporter
D0812_10285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0812_10295	COG0131	Imidazoleglycerol-phosphate dehydratase
D0812_10295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0812_10300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0812_10305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0812_10310	COG0107	imidazoleglycerol-phosphate synthase activity
D0812_10315	COG0140	phosphoribosyl-ATP diphosphatase activity
D0812_10315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0812_10320	COG3012	SEC-C Motif Domain Protein
D0812_10325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0812_10330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0812_10335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0812_10340	COG0215	cysteine-tRNA ligase activity
D0812_10345	COG1435	thymidine kinase activity
D0812_10350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0812_10375	COG2116	formate transmembrane transporter activity
D0812_10380	COG0390	transport system, permease component
D0812_10385	COG4459	periplasmic nitrate reductase
D0812_10390	COG3005	denitrification pathway
D0812_10395	COG0243	molybdopterin cofactor binding
D0812_10410	COG1227	inorganic diphosphatase activity
D0812_10420	COG4172	Belongs to the ABC transporter superfamily
D0812_10430	COG4171	peptide transport system, permease
D0812_10435	COG4168	peptide transport system, permease
D0812_10445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0812_10450	COG1842	Phage shock protein A
D0812_10460	COG1983	PspC domain protein
D0812_10480	COG2818	Glycosylase
D0812_10485	COG5380	lipid catabolic process
D0812_10490	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D0812_10495	COG0626	cystathionine gamma-synthase activity
D0812_10505	COG0733	neurotransmitter:sodium symporter activity
D0812_10515	COG0564	pseudouridine synthase activity
D0812_10530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0812_10535	COG1151	hydroxylamine reductase activity
D0812_10540	COG3604	Transcriptional regulator
D0812_10545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0812_10550	COG4136	ATPase activity
D0812_10555	COG4135	transport system, permease component
D0812_10560	COG4134	Bacterial extracellular solute-binding protein
D0812_10565	COG0398	Pfam SNARE associated Golgi protein
D0812_10575	COG0493	'glutamate synthase
D0812_10600	COG0659	secondary active sulfate transmembrane transporter activity
D0812_10610	COG3313	Fe-S protein
D0812_10660	COG2205	protein histidine kinase activity
D0812_10665	COG0745	RESPONSE REGULATOR receiver
D0812_10675	COG2199	diguanylate cyclase activity
D0812_10680	COG1061	Type III restriction enzyme res subunit
D0812_10685	COG1187	pseudouridine synthase activity
D0812_10690	COG2814	Major facilitator Superfamily
D0812_10700	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_10705	COG0702	epimerase
D0812_10710	COG0534	Mate efflux family protein
D0812_10715	COG4181	ATPase activity
D0812_10745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0812_10755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0812_10765	COG1737	Transcriptional regulator
D0812_10770	COG0076	glutamate decarboxylase activity
D0812_10780	COG2431	L-lysine efflux transmembrane transporter activity
D0812_10795	COG3070	regulator of competence-specific genes
D0812_10810	COG4191	Histidine kinase
D0812_10810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_10820	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0812_10860	COG2200	EAL domain
D0812_10865	COG0583	DNA-binding transcription factor activity
D0812_10875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0812_10880	COG4988	ABC transporter
D0812_10885	COG0492	ferredoxin-NADP+ reductase activity
D0812_10905	COG3706	GGDEF domain
D0812_10910	COG0471	metal ion transport
D0812_10915	COG2949	membrane
D0812_10925	COG1643	Atp-dependent helicase
D0812_10930	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D0812_10990	COG0247	lactate metabolic process
D0812_10990	COG0277	FAD linked oxidase domain protein
D0812_11005	COG2986	histidine ammonia-lyase
D0812_11015	COG0010	Belongs to the arginase family
D0812_11025	COG2188	Transcriptional regulator
D0812_11050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0812_11070	COG0251	oxidation-reduction process
D0812_11110	COG2199	diguanylate cyclase activity
D0812_11120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0812_11120	COG0072	phenylalanine-tRNA ligase activity
D0812_11130	COG1621	beta-fructofuranosidase activity
D0812_11135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_11180	COG1346	cytolysis
D0812_11190	COG2925	Exonuclease
D0812_11205	COG0702	epimerase
D0812_11210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0812_11220	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D0812_11245	COG4139	cobalamin transport
D0812_11275	COG0583	DNA-binding transcription factor activity
D0812_11305	COG1451	nucleotide metabolic process
D0812_11315	COG0745	RESPONSE REGULATOR receiver
D0812_11315	COG3706	GGDEF domain
D0812_11325	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0812_11340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0812_11350	COG0625	glutathione transferase activity
D0812_11360	COG0657	acetylesterase activity
D0812_11390	COG4565	transcriptional regulatory protein
D0812_11400	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D0812_11405	COG0511	ligase activity, forming carbon-carbon bonds
D0812_11405	COG5016	pyruvate
D0812_11410	COG3630	sodium ion export across plasma membrane
D0812_11420	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D0812_11425	COG3052	prosthetic group binding
D0812_11430	COG2301	Belongs to the HpcH HpaI aldolase family
D0812_11435	COG3051	citrate lyase alpha subunit
D0812_11440	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D0812_11445	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D0812_11460	COG2197	response regulator
D0812_11475	COG1349	DNA-binding transcription factor activity
D0812_11480	COG0738	Major facilitator superfamily
D0812_11485	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
D0812_11490	COG1070	Carbohydrate kinase
D0812_11495	COG4154	Belongs to the RbsD FucU family
D0812_11500	COG0235	Class ii aldolase
D0812_11505	COG1454	alcohol dehydrogenase
D0812_11520	COG0589	response to stress
D0812_11525	COG0519	Catalyzes the synthesis of GMP from XMP
D0812_11590	COG0745	RESPONSE REGULATOR receiver
D0812_11605	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D0812_11620	COG0668	transmembrane transport
D0812_11625	COG3247	response to pH
D0812_11630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0812_11645	COG1846	Transcriptional regulator
D0812_11690	COG0110	maltose O-acetyltransferase activity
D0812_11710	COG3437	response regulator, receiver
D0812_11710	COG3850	Histidine kinase
D0812_11710	COG4999	Histidine kinase
D0812_11710	COG2205	protein histidine kinase activity
D0812_11715	COG3300	MHYT domain
D0812_11715	COG5001	Diguanylate cyclase
D0812_11740	COG3064	Membrane
D0812_11750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0812_11755	COG1215	transferase activity, transferring glycosyl groups
D0812_11760	COG0297	glycogen (starch) synthase activity
D0812_11800	COG0438	transferase activity, transferring glycosyl groups
D0812_11810	COG2204	response regulator
D0812_11830	COG2885	chlorophyll binding
D0812_11840	COG1793	dna ligase
D0812_11850	COG0534	Mate efflux family protein
D0812_11855	COG0307	riboflavin synthase, alpha
D0812_11870	COG2201	protein-glutamate methylesterase activity
D0812_11875	COG3706	GGDEF domain
D0812_11885	COG0791	NLP P60 protein
D0812_11890	COG0840	transmembrane signaling receptor activity
D0812_11945	COG1940	carbohydrate kinase activity
D0812_11960	COG0303	'Molybdopterin
D0812_11970	COG3842	ATPase activity
D0812_11975	COG4662	Binding-protein-dependent transport system inner membrane component
D0812_11985	COG2204	response regulator
D0812_11990	COG4191	Histidine kinase
D0812_12010	COG0488	(ABC) transporter
D0812_12015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0812_12035	COG3381	protein complex oligomerization
D0812_12045	COG0243	molybdopterin cofactor binding
D0812_12045	COG3383	formate dehydrogenase (NAD+) activity
D0812_12050	COG0437	4 iron, 4 sulfur cluster binding
D0812_12065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0812_12070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0812_12075	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0812_12080	COG1177	transmembrane transport
D0812_12085	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0812_12090	COG3842	ATPase activity
D0812_12115	COG0589	response to stress
D0812_12120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0812_12135	COG2217	Heavy metal translocating P-type atpase
D0812_12145	COG2010	Cytochrome c
D0812_12160	COG3278	Belongs to the heme-copper respiratory oxidase family
D0812_12175	COG0784	Response regulator, receiver
D0812_12175	COG2205	protein histidine kinase activity
D0812_12205	COG1067	ATP-dependent peptidase activity
D0812_12250	COG2902	Dehydrogenase
D0812_12260	COG0308	aminopeptidase N
D0812_12270	COG0793	Belongs to the peptidase S41A family
D0812_12275	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D0812_12280	COG1956	GAF domain-containing protein
D0812_12285	COG1132	(ABC) transporter
D0812_12290	COG2995	paraquat-inducible protein a
D0812_12295	COG3008	intermembrane lipid transfer
D0812_12320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0812_12340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_12345	COG4597	amino acid ABC transporter
D0812_12350	COG0765	amino acid transport
D0812_12355	COG1126	abc transporter atp-binding protein
D0812_12360	COG0670	Belongs to the BI1 family
D0812_12370	COG2920	part of a sulfur-relay system
D0812_12375	COG1254	Belongs to the acylphosphatase family
D0812_12425	COG3706	GGDEF domain
D0812_12435	COG0602	queuosine metabolic process
D0812_12440	COG0561	phosphatase activity
D0812_12465	COG2828	Protein conserved in bacteria
D0812_12475	COG0372	Belongs to the citrate synthase family
D0812_12480	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0812_12495	COG3501	Rhs element vgr protein
D0812_12590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_12595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0812_12630	COG0730	response to heat
D0812_12635	COG0840	transmembrane signaling receptor activity
D0812_12645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_12655	COG1902	pentaerythritol trinitrate reductase activity
D0812_12660	COG1012	belongs to the aldehyde dehydrogenase family
D0812_12665	COG3284	Transcriptional regulator
D0812_12695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0812_12700	COG0363	glucosamine-6-phosphate deaminase activity
D0812_12705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0812_12710	COG4565	transcriptional regulatory protein
D0812_12715	COG3290	protein histidine kinase activity
D0812_12720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_12840	COG3012	SEC-C Motif Domain Protein
D0812_12895	COG2842	Transposition protein
D0812_12905	COG3423	Transcriptional regulator
D0812_12925	COG2951	lytic endotransglycosylase activity
D0812_12940	COG2894	cell division
D0812_12945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D0812_12950	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0812_12955	COG0318	PFAM AMP-dependent synthetase and ligase
D0812_12960	COG2267	carboxylic ester hydrolase activity
D0812_12965	COG3065	identical protein binding
D0812_12975	COG1214	PFAM Peptidase M22, glycoprotease
D0812_12980	COG1199	ATP-dependent helicase activity
D0812_12985	COG0788	formyltetrahydrofolate deformylase activity
D0812_12990	COG3102	Protein conserved in bacteria
D0812_13020	COG1918	ferrous iron import across plasma membrane
D0812_13025	COG4977	sequence-specific DNA binding
D0812_13030	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D0812_13035	COG1121	(ABC) transporter
D0812_13040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0812_13055	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0812_13060	COG0567	Dehydrogenase, E1 component
D0812_13070	COG1053	succinate dehydrogenase
D0812_13075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0812_13080	COG2009	succinate dehydrogenase
D0812_13090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0812_13100	COG0033	Phosphoglucomutase
D0812_13110	COG0596	Alpha beta hydrolase
D0812_13120	COG0716	FMN binding
D0812_13130	COG0735	belongs to the Fur family
D0812_13145	COG1263	PTS System
D0812_13145	COG2190	(PTS) system
D0812_13145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_13155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0812_13160	COG1940	carbohydrate kinase activity
D0812_13160	COG1846	Transcriptional regulator
D0812_13165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0812_13165	COG4651	solute:proton antiporter activity
D0812_13170	COG0367	asparagine synthase
D0812_13175	COG0250	Participates in transcription elongation, termination and antitermination
D0812_13180	COG3104	oligopeptide transport
D0812_13185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0812_13200	COG3710	Transcriptional regulator
D0812_13220	COG0622	Phosphoesterase
D0812_13250	COG1090	epimerase
D0812_13255	COG0300	oxidoreductase activity
D0812_13265	COG3118	belongs to the thioredoxin family
D0812_13275	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D0812_13280	COG1215	transferase activity, transferring glycosyl groups
D0812_13285	COG1215	transferase activity, transferring glycosyl groups
D0812_13305	COG2194	sulfuric ester hydrolase activity
D0812_13310	COG0330	HflC and HflK could
D0812_13350	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D0812_13355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0812_13365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_13370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0812_13375	COG2190	(PTS) system
D0812_13380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_13385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_13390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_13405	COG3951	Flagellar rod assembly protein muramidase FlgJ
D0812_13405	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0812_13410	COG1706	bacterial-type flagellum-dependent cell motility
D0812_13415	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0812_13420	COG4786	Flagellar basal body rod
D0812_13425	COG4787	bacterial-type flagellum-dependent cell motility
D0812_13430	COG1749	Flagellar hook protein flgE
D0812_13435	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0812_13440	COG1558	bacterial-type flagellum-dependent cell motility
D0812_13445	COG1815	bacterial-type flagellum-dependent cell motility
D0812_13450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0812_13455	COG0835	chemotaxis
D0812_13455	COG0784	Response regulator, receiver
D0812_13510	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0812_13525	COG2608	mercury ion transmembrane transporter activity
D0812_13525	COG2217	Heavy metal translocating P-type atpase
D0812_13560	COG2840	Smr protein MutS2
D0812_13565	COG1187	pseudouridine synthase activity
D0812_13570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0812_13575	COG0737	Belongs to the 5'-nucleotidase family
D0812_13585	COG2912	Transglutaminase-like superfamily
D0812_13590	COG3094	Invasion gene expression up-regulator, SirB
D0812_13595	COG2890	protein-(glutamine-N5) methyltransferase activity
D0812_13620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0812_13740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0812_13755	COG1702	phosphate starvation-inducible protein PhoH
D0812_13765	COG4535	Mg2 and Co2 transporter CorC
D0812_13770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0812_13775	COG2888	peptidyl-tyrosine sulfation
D0812_13780	COG0495	leucyl-tRNA aminoacylation
D0812_13785	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D0812_13790	COG1466	dna polymerase III delta subunit
D0812_13795	COG0799	negative regulation of ribosome biogenesis
D0812_13805	COG0768	penicillin binding
D0812_13810	COG0772	Belongs to the SEDS family
D0812_13815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0812_13820	COG1686	Belongs to the peptidase S11 family
D0812_13840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0812_13845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0812_13860	COG0366	Alpha amylase catalytic
D0812_13865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_13865	COG1263	PTS System
D0812_13875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0812_13880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0812_13885	COG2011	ABC-type metal ion transport system permease component
D0812_13890	COG1464	Belongs to the NlpA lipoprotein family
D0812_13900	COG0737	Belongs to the 5'-nucleotidase family
D0812_13905	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D0812_13925	COG0745	RESPONSE REGULATOR receiver
D0812_13925	COG3706	GGDEF domain
D0812_13930	COG1611	Belongs to the LOG family
D0812_13945	COG2363	Small membrane protein
D0812_13955	COG0583	DNA-binding transcription factor activity
D0812_13970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0812_13980	COG0142	geranyltranstransferase activity
D0812_13990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0812_13995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D0812_14020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0812_14020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0812_14025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0812_14030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0812_14055	COG2252	PERMEase
D0812_14060	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0812_14095	COG0047	phosphoribosylformylglycinamidine synthase activity
D0812_14095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0812_14110	COG0590	tRNA wobble adenosine to inosine editing
D0812_14120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0812_14165	COG1301	dicarboxylic acid transport
D0812_14185	COG0497	DNA recombination
D0812_14190	COG0456	acetyltransferase
D0812_14195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_14205	COG2914	Belongs to the UPF0125 (RnfH) family
D0812_14210	COG2867	negative regulation of translational initiation
D0812_14225	COG0583	DNA-binding transcription factor activity
D0812_14230	COG1289	transmembrane transporter activity
D0812_14250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0812_14255	COG2873	o-acetylhomoserine
D0812_14260	COG0668	transmembrane transport
D0812_14275	COG0583	DNA-binding transcription factor activity
D0812_14285	COG1115	amino acid carrier protein
D0812_14290	COG1584	GPR1 FUN34 yaaH family protein
D0812_14300	COG1757	Na H antiporter
D0812_14310	COG0516	GMP reductase activity
D0812_14310	COG0517	IMP dehydrogenase activity
D0812_14325	COG2199	diguanylate cyclase activity
D0812_14325	COG2203	Gaf domain
D0812_14340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_14345	COG2976	Protein conserved in bacteria
D0812_14380	COG2975	iron-sulfur cluster assembly
D0812_14385	COG0633	Ferredoxin
D0812_14400	COG0316	Belongs to the HesB IscA family
D0812_14405	COG0822	iron-sulfur transferase activity
D0812_14420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D0812_14430	COG0483	inositol monophosphate 1-phosphatase activity
D0812_14435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_14440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_14445	COG1862	Preprotein translocase
D0812_14470	COG0517	IMP dehydrogenase activity
D0812_14480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0812_14485	COG0583	DNA-binding transcription factor activity
D0812_14490	COG0450	alkyl hydroperoxide reductase
D0812_14520	COG0704	Plays a role in the regulation of phosphate uptake
D0812_14525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0812_14530	COG0581	inorganic phosphate transmembrane transporter activity
D0812_14535	COG0573	inorganic phosphate transmembrane transporter activity
D0812_14540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0812_14545	COG0248	Ppx GppA phosphatase
D0812_14555	COG5002	protein histidine kinase activity
D0812_14560	COG0745	RESPONSE REGULATOR receiver
D0812_14575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0812_14635	COG0542	response to heat
D0812_14645	COG0564	pseudouridine synthase activity
D0812_14650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_14655	COG0741	lytic transglycosylase activity
D0812_14660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0812_14665	COG0077	Prephenate dehydratase
D0812_14665	COG1605	Chorismate mutase
D0812_14670	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D0812_14685	COG0488	(ABC) transporter
D0812_14695	COG0739	heme binding
D0812_14700	COG0287	Prephenate dehydrogenase
D0812_14700	COG1605	Chorismate mutase
D0812_14705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0812_14710	COG1472	Belongs to the glycosyl hydrolase 3 family
D0812_14715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D0812_14735	COG1966	Carbon starvation protein
D0812_14740	COG3275	phosphorelay sensor kinase activity
D0812_14745	COG3279	Response regulator of the LytR AlgR family
D0812_14750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0812_14755	COG1047	Peptidyl-prolyl cis-trans
D0812_14770	COG0196	riboflavin kinase activity
D0812_14775	COG0728	peptidoglycan biosynthetic process
D0812_14780	COG0268	Binds directly to 16S ribosomal RNA
D0812_14785	COG0640	Transcriptional regulator
D0812_14790	COG0583	DNA-binding transcription factor activity
D0812_14795	COG1283	sodium-dependent phosphate transmembrane transporter activity
D0812_14815	COG0730	response to heat
D0812_14840	COG0667	Aldo Keto reductase
D0812_14865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0812_14870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0812_14880	COG0716	FMN binding
D0812_14895	COG0513	Belongs to the DEAD box helicase family
D0812_14905	COG3022	response to hydroperoxide
D0812_14910	COG1115	amino acid carrier protein
D0812_14950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0812_14955	COG0083	homoserine kinase activity
D0812_14970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0812_14985	COG0745	RESPONSE REGULATOR receiver
D0812_14995	COG5002	protein histidine kinase activity
D0812_14995	COG0784	Response regulator, receiver
D0812_14995	COG2198	Histidine kinase
D0812_15000	COG5001	Diguanylate cyclase
D0812_15000	COG3706	GGDEF domain
D0812_15000	COG4251	negative regulation of phosphorylation
D0812_15000	COG2203	Gaf domain
D0812_15005	COG1242	4 iron, 4 sulfur cluster binding
D0812_15010	COG0070	glutamate synthase
D0812_15010	COG0067	glutamate synthase
D0812_15010	COG0069	glutamate synthase activity
D0812_15020	COG0069	glutamate synthase activity
D0812_15020	COG0070	glutamate synthase
D0812_15020	COG0067	glutamate synthase
D0812_15025	COG0493	'glutamate synthase
D0812_15050	COG2860	membrane
D0812_15055	COG0583	DNA-binding transcription factor activity
D0812_15060	COG0730	response to heat
D0812_15075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0812_15080	COG0505	Belongs to the CarA family
D0812_15090	COG0494	nUDIX hydrolase
D0812_15110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0812_15115	COG0849	cell division
D0812_15120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0812_15135	COG0772	Belongs to the SEDS family
D0812_15150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0812_15155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0812_15160	COG0768	penicillin binding
D0812_15165	COG3116	cell division
D0812_15185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0812_15200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0812_15205	COG2823	Periplasmic or secreted lipoprotein
D0812_15210	COG2969	positive regulation of protein catabolic process
D0812_15215	COG0625	glutathione transferase activity
D0812_15220	COG2857	Cytochrome c1
D0812_15225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0812_15230	COG0723	plastoquinol--plastocyanin reductase activity
D0812_15250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0812_15260	COG3105	Protein conserved in bacteria
D0812_15265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0812_15270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0812_15275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0812_15280	COG0187	DNA topoisomerase II activity
D0812_15285	COG3150	esterase
D0812_15295	COG3151	Protein conserved in bacteria
D0812_15300	COG0494	nUDIX hydrolase
D0812_15305	COG1538	Outer membrane efflux protein
D0812_15315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0812_15325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0812_15330	COG3025	triphosphatase activity
D0812_15335	COG1392	Phosphate transport regulator
D0812_15340	COG0306	phosphate transporter
D0812_15345	COG4991	sh3 domain protein
D0812_15350	COG0405	Gamma-glutamyltransferase
D0812_15365	COG3409	Peptidoglycan-binding domain 1 protein
D0812_15365	COG3267	Type II secretory pathway component ExeA
D0812_15380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0812_15385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0812_15395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0812_15400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0812_15405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0812_15410	COG1610	YqeY-like protein
D0812_15415	COG0358	DNA primase activity
D0812_15420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0812_15450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_15450	COG2213	PTS system mannitol-specific
D0812_15460	COG3722	fumarate hydratase activity
D0812_15465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_15470	COG5002	protein histidine kinase activity
D0812_15490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0812_15495	COG1349	DNA-binding transcription factor activity
D0812_15505	COG0469	pyruvate kinase activity
D0812_15515	COG3706	GGDEF domain
D0812_15525	COG0028	Belongs to the TPP enzyme family
D0812_15530	COG1022	Amp-dependent synthetase and ligase
D0812_15535	COG0583	DNA-binding transcription factor activity
D0812_15565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0812_15570	COG0473	3-isopropylmalate dehydrogenase activity
D0812_15590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0812_15595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0812_15600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0812_15605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0812_15630	COG3610	response to peptide
D0812_15635	COG2966	Psort location CytoplasmicMembrane, score
D0812_15650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0812_15655	COG0142	geranyltranstransferase activity
D0812_15695	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D0812_15700	COG1178	ABC-type Fe3 transport system permease component
D0812_15705	COG4143	(ABC) transporter
D0812_15710	COG0163	prenyltransferase activity
D0812_15715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0812_15725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0812_15740	COG2105	PFAM AIG2 family protein
D0812_15750	COG0729	surface antigen
D0812_15755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_15785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0812_15815	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0812_15830	COG1136	(ABC) transporter
D0812_15850	COG0529	Catalyzes the synthesis of activated sulfate
D0812_15855	COG0471	metal ion transport
D0812_15855	COG3273	potassium ion transport
D0812_15870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0812_15870	COG1648	precorrin-2 dehydrogenase activity
D0812_15875	COG0737	Belongs to the 5'-nucleotidase family
D0812_15890	COG0513	Belongs to the DEAD box helicase family
D0812_15895	COG2153	protein acetylation
D0812_15910	COG0545	Peptidyl-prolyl cis-trans isomerase
D0812_15920	COG0203	ribosomal protein L17
D0812_15925	COG0202	RNA polymerase activity
D0812_15935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0812_15940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0812_15950	COG0201	protein transport
D0812_15960	COG1841	ribosomal large subunit assembly
D0812_15990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0812_16025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0812_16045	COG0088	Forms part of the polypeptide exit tunnel
D0812_16060	COG0254	rRNA binding
D0812_16070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0812_16075	COG1609	Transcriptional regulator
D0812_16095	COG1575	Belongs to the MenA family. Type 1 subfamily
D0812_16100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0812_16110	COG1494	fructose-1,6-bisphosphatase
D0812_16140	COG0149	triose-phosphate isomerase activity
D0812_16155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0812_16160	COG0517	IMP dehydrogenase activity
D0812_16160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0812_16165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D0812_16170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D0812_16175	COG1215	transferase activity, transferring glycosyl groups
D0812_16210	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_16285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0812_16295	COG1560	Kdo2-lipid A biosynthetic process
D0812_16310	COG1519	Transferase
D0812_16325	COG0367	asparagine synthase
D0812_16350	COG1083	cytidylyl-transferase
D0812_16355	COG3642	lipopolysaccharide core region biosynthetic process
D0812_16360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0812_16365	COG0859	PFAM glycosyl transferase family 9
D0812_16370	COG0463	Glycosyl transferase, family 2
D0812_16385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0812_16425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0812_16435	COG1560	Kdo2-lipid A biosynthetic process
D0812_16445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0812_16450	COG1561	YicC-like family, N-terminal region
D0812_16455	COG0745	RESPONSE REGULATOR receiver
D0812_16480	COG4608	Belongs to the ABC transporter superfamily
D0812_16485	COG0444	Belongs to the ABC transporter superfamily
D0812_16490	COG0747	negative chemotaxis
D0812_16495	COG4239	(ABC) transporter, permease
D0812_16500	COG4174	ABC transporter (Permease)
D0812_16525	COG0811	peptide transport
D0812_16530	COG0848	biopolymer transport protein
D0812_16545	COG0194	GDP metabolic process
D0812_16550	COG1758	RNA polymerase activity
D0812_16555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0812_16560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0812_16565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0812_16575	COG2233	PERMEase
D0812_16580	COG2205	protein histidine kinase activity
D0812_16585	COG0745	RESPONSE REGULATOR receiver
D0812_16590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_16600	COG2183	response to ionizing radiation
D0812_16625	COG0494	nUDIX hydrolase
D0812_16630	COG1218	3'(2'),5'-bisphosphate nucleotidase
D0812_16640	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0812_16645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0812_16650	COG3156	type II secretion system protein K
D0812_16655	COG4795	General secretion pathway protein
D0812_16660	COG2165	general secretion pathway protein
D0812_16665	COG2165	general secretion pathway protein
D0812_16670	COG2165	general secretion pathway protein
D0812_16675	COG1459	type II secretion system
D0812_16680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_16690	COG3031	protein transport across the cell outer membrane
D0812_16695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0812_16715	COG0456	acetyltransferase
D0812_16720	COG1490	D-aminoacyl-tRNA deacylase activity
D0812_16750	COG0174	glutamine synthetase
D0812_16760	COG3852	Histidine kinase
D0812_16765	COG2204	response regulator
D0812_16775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0812_16780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0812_16810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0812_16820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0812_16820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0812_16840	COG0084	hydrolase, TatD family'
D0812_16845	COG0805	protein transport
D0812_16865	COG3165	ubiquinone biosynthetic process from chorismate
D0812_16875	COG1322	Protein conserved in bacteria
D0812_16910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D0812_16985	COG2081	HI0933 family
D0812_17020	COG1528	Iron-storage protein
D0812_17025	COG0589	response to stress
D0812_17030	COG0697	spore germination
D0812_17045	COG5002	protein histidine kinase activity
D0812_17045	COG5001	Diguanylate cyclase
D0812_17050	COG1522	sequence-specific DNA binding
D0812_17065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0812_17075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0812_17120	COG3501	Rhs element vgr protein
D0812_17150	COG0800	Aldolase
D0812_17155	COG2610	gluconate transmembrane transporter activity
D0812_17160	COG3265	gluconokinase activity
D0812_17165	COG0129	dihydroxy-acid dehydratase activity
D0812_17175	COG2076	Multidrug Resistance protein
D0812_17180	COG0583	DNA-binding transcription factor activity
D0812_17185	COG1609	Transcriptional regulator
D0812_17220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0812_17235	COG4172	Belongs to the ABC transporter superfamily
D0812_17285	COG1309	transcriptional regulator
D0812_17290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_17295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_17305	COG2960	long-chain fatty acid transporting porin activity
D0812_17310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0812_17315	COG0583	DNA-binding transcription factor activity
D0812_17360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0812_17385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0812_17390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0812_17395	COG0551	DNA topoisomerase type I activity
D0812_17405	COG0758	DNA mediated transformation
D0812_17415	COG0242	peptide deformylase activity
D0812_17425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0812_17425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0812_17430	COG0569	domain protein
D0812_17435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_17445	COG1272	protein, Hemolysin III
D0812_17450	COG4326	sporulation control protein
D0812_17460	COG3084	Protein conserved in bacteria
D0812_17470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0812_17475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0812_17480	COG0204	Acyl-transferase
D0812_17490	COG0606	chelatase, subunit chli
D0812_17500	COG3978	acetolactate synthase activity
D0812_17505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0812_17510	COG0129	dihydroxy-acid dehydratase activity
D0812_17520	COG3706	GGDEF domain
D0812_17525	COG0583	DNA-binding transcription factor activity
D0812_17530	COG2814	Major facilitator Superfamily
D0812_17535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_17540	COG0765	amino acid transport
D0812_17550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0812_17560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0812_17590	COG3312	ion transport
D0812_17595	COG1475	DNA binding
D0812_17600	COG1192	Involved in chromosome partitioning
D0812_17615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0812_17630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0812_17645	COG1126	abc transporter atp-binding protein
D0812_17660	COG3835	regulator
D0812_17665	COG1929	Belongs to the glycerate kinase type-1 family
D0812_17670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_17715	COG0456	acetyltransferase
D0812_17735	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_17745	COG3005	denitrification pathway
D0812_17750	COG0243	molybdopterin cofactor binding
D0812_17755	COG5002	protein histidine kinase activity
D0812_17765	COG0671	phosphoesterase, PA-phosphatase related
D0812_17790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D0812_17795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0812_17800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0812_17805	COG1116	anion transmembrane transporter activity
D0812_17810	COG0351	phosphomethylpyrimidine kinase
D0812_17815	COG0312	modulator of DNA gyrase
D0812_17820	COG0312	modulator of DNA gyrase
D0812_17885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0812_17895	COG0584	glycerophosphoryl diester phosphodiesterase
D0812_17905	COG0745	RESPONSE REGULATOR receiver
D0812_17925	COG0811	peptide transport
D0812_17930	COG0811	peptide transport
D0812_17935	COG0848	biopolymer transport protein
D0812_17980	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0812_17985	COG1121	(ABC) transporter
D0812_17990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0812_18005	COG1770	oligopeptidase
D0812_18010	COG2814	Major facilitator Superfamily
D0812_18015	COG0010	Belongs to the arginase family
D0812_18020	COG1166	arginine decarboxylase activity
D0812_18030	COG4067	protein conserved in archaea
D0812_18030	COG0189	ligase activity
D0812_18035	COG0189	ligase activity
D0812_18060	COG0583	DNA-binding transcription factor activity
D0812_18100	COG3706	GGDEF domain
D0812_18125	COG0579	oxidoreductase
D0812_18145	COG3033	Beta-eliminating lyase
D0812_18165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0812_18170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0812_18190	COG3706	GGDEF domain
D0812_18205	COG3706	GGDEF domain
D0812_18210	COG0415	Belongs to the DNA photolyase family
D0812_18215	COG3046	protein related to deoxyribodipyrimidine photolyase
D0812_18230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_18230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_18235	COG1765	OsmC-like protein
D0812_18240	COG2171	N-acyltransferase activity
D0812_18275	COG1011	Hydrolase
D0812_18310	COG3240	lipase activity
D0812_18340	COG1609	Transcriptional regulator
D0812_18360	COG1840	ABC-type Fe3 transport system, periplasmic component
D0812_18370	COG3842	ATPase activity
D0812_18395	COG2990	Protein conserved in bacteria
D0812_18405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0812_18410	COG2866	Carboxypeptidase
D0812_18420	COG0583	DNA-binding transcription factor activity
D0812_18450	COG1760	l-serine dehydratase
D0812_18475	COG0741	lytic transglycosylase activity
D0812_18475	COG1388	LysM domain
D0812_18495	COG1815	bacterial-type flagellum-dependent cell motility
D0812_18500	COG1558	bacterial-type flagellum-dependent cell motility
D0812_18505	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0812_18510	COG1749	Flagellar hook protein flgE
D0812_18515	COG4787	bacterial-type flagellum-dependent cell motility
D0812_18520	COG4786	Flagellar basal body rod
D0812_18525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0812_18530	COG1706	bacterial-type flagellum-dependent cell motility
D0812_18540	COG1256	bacterial-type flagellum assembly
D0812_18540	COG4786	Flagellar basal body rod
D0812_18545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_18570	COG0583	DNA-binding transcription factor activity
D0812_18590	COG1253	flavin adenine dinucleotide binding
D0812_18595	COG3710	Transcriptional regulator
D0812_18610	COG2226	methyltransferase
D0812_18665	COG1360	Flagellar Motor Protein
D0812_18670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0812_18675	COG1191	sigma factor activity
D0812_18680	COG1580	Controls the rotational direction of flagella during chemotaxis
D0812_18695	COG1516	flagellar protein fliS
D0812_18700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0812_18710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0812_18725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0812_18735	COG1987	bacterial-type flagellum assembly
D0812_18760	COG2204	response regulator
D0812_18775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0812_18795	COG5002	protein histidine kinase activity
D0812_18795	COG5001	Diguanylate cyclase
D0812_18810	COG0697	spore germination
D0812_18855	COG0346	lactoylglutathione lyase activity
D0812_18880	COG0745	RESPONSE REGULATOR receiver
D0812_18905	COG0156	8-amino-7-oxononanoate synthase activity
D0812_18910	COG1063	alcohol dehydrogenase
D0812_18970	COG0668	transmembrane transport
D0812_18985	COG1304	FMN binding
D0812_18990	COG1620	l-lactate permease
D0812_18995	COG0583	DNA-binding transcription factor activity
D0812_19000	COG1505	serine-type exopeptidase activity
D0812_19005	COG4172	Belongs to the ABC transporter superfamily
D0812_19015	COG1067	ATP-dependent peptidase activity
D0812_19025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0812_19045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_19050	COG0437	4 iron, 4 sulfur cluster binding
D0812_19055	COG0348	domain, Protein
D0812_19070	COG0640	Transcriptional regulator
D0812_19080	COG2731	YhcH YjgK YiaL family protein
D0812_19095	COG1122	ATPase activity
D0812_19105	COG1566	PFAM secretion protein HlyD family protein
D0812_19120	COG3706	GGDEF domain
D0812_19135	COG0813	purine-nucleoside phosphorylase activity
D0812_19145	COG3272	Protein of unknown function (DUF1722)
D0812_19150	COG0789	Transcriptional regulator
D0812_19155	COG0415	Belongs to the DNA photolyase family
D0812_19160	COG1376	ErfK ybiS ycfS ynhG family protein
D0812_19160	COG1388	LysM domain
D0812_19170	COG0513	Belongs to the DEAD box helicase family
D0812_19230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D0812_19240	COG4974	Belongs to the 'phage' integrase family
D0812_19260	COG1770	oligopeptidase
D0812_19265	COG4771	TonB-dependent receptor
D0812_19290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0812_19295	COG0573	inorganic phosphate transmembrane transporter activity
D0812_19300	COG0581	inorganic phosphate transmembrane transporter activity
D0812_19305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0812_19320	COG2304	oxidoreductase activity
D0812_19340	COG0714	Associated with various cellular activities
D0812_19360	COG0840	transmembrane signaling receptor activity
D0812_19395	COG0110	maltose O-acetyltransferase activity
D0812_19400	COG2204	response regulator
D0812_19405	COG4191	Histidine kinase
D0812_19415	COG0573	inorganic phosphate transmembrane transporter activity
D0812_19425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0812_19430	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_19445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0812_19445	COG2885	chlorophyll binding
D0812_19480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0812_19485	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D0812_19495	COG1252	NADH dehydrogenase
D0812_19500	COG1301	dicarboxylic acid transport
D0812_19510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_19545	COG1566	PFAM secretion protein HlyD family protein
D0812_19550	COG0583	DNA-binding transcription factor activity
D0812_19565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_19565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_19565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_19570	COG2207	Transcriptional regulator
D0812_19580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_19585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_19590	COG0583	DNA-binding transcription factor activity
D0812_19600	COG2084	Dehydrogenase
D0812_19605	COG0753	catalase activity
D0812_19615	COG2130	NADP-dependent
D0812_19620	COG1309	transcriptional regulator
D0812_19660	COG0438	transferase activity, transferring glycosyl groups
D0812_19685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0812_19690	COG3842	ATPase activity
D0812_19705	COG1175	transmembrane transport
D0812_19710	COG3833	ABC-type maltose transport systems, permease component
D0812_19740	COG2354	Protein conserved in bacteria
D0812_19750	COG0401	homolog of Blt101
D0812_19755	COG3217	Mosc domain protein beta barrel domain protein
D0812_19755	COG0633	Ferredoxin
D0812_19755	COG3217	Mosc domain protein beta barrel domain protein
D0812_19755	COG0633	Ferredoxin
D0812_19765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0812_19805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D0812_19810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_19820	COG0848	biopolymer transport protein
D0812_19825	COG0811	peptide transport
D0812_19830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D0812_19840	COG3721	Heme iron utilization protein
D0812_19845	COG0748	coenzyme F420 binding
D0812_19860	COG0784	Response regulator, receiver
D0812_19860	COG0835	chemotaxis
D0812_19865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0812_19870	COG0366	Alpha amylase catalytic
D0812_19930	COG0583	DNA-binding transcription factor activity
D0812_19950	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_19955	COG0583	DNA-binding transcription factor activity
D0812_19975	COG2814	Major facilitator Superfamily
D0812_19990	COG1335	isochorismatase
D0812_20005	COG2194	sulfuric ester hydrolase activity
D0812_20010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0812_20020	COG2205	protein histidine kinase activity
D0812_20025	COG0745	RESPONSE REGULATOR receiver
D0812_20030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_20035	COG4948	Mandelate Racemase Muconate Lactonizing
D0812_20040	COG3976	FMN-binding domain protein
D0812_20040	COG1053	succinate dehydrogenase
D0812_20050	COG4221	oxidoreductase activity
D0812_20065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0812_20085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0812_20095	COG2814	Major facilitator Superfamily
D0812_20110	COG1418	mRNA catabolic process
D0812_20125	COG0402	S-adenosylhomocysteine deaminase activity
D0812_20130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0812_20135	COG2239	Acts as a magnesium transporter
D0812_20140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0812_20145	COG1566	PFAM secretion protein HlyD family protein
D0812_20170	COG0745	RESPONSE REGULATOR receiver
D0812_20175	COG2205	protein histidine kinase activity
D0812_20195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_20205	COG0531	amino acid
D0812_20210	COG1522	sequence-specific DNA binding
D0812_20245	COG0673	inositol 2-dehydrogenase activity
D0812_20325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_20330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0812_20340	COG1280	lysine exporter protein (LysE YggA)
D0812_20350	COG0183	Belongs to the thiolase family
D0812_20370	COG3005	denitrification pathway
D0812_20390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0812_20395	COG3850	Histidine kinase
D0812_20400	COG2197	response regulator
D0812_20415	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0812_20435	COG0840	transmembrane signaling receptor activity
D0812_20445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_20475	COG0545	Peptidyl-prolyl cis-trans isomerase
D0812_20505	COG1278	Cold shock
D0812_20510	COG3036	rescue of stalled ribosome
D0812_20520	COG3706	GGDEF domain
D0812_20540	COG1136	(ABC) transporter
D0812_20540	COG0577	efflux transmembrane transporter activity
D0812_20570	COG1538	Outer membrane efflux protein
D0812_20575	COG0784	Response regulator, receiver
D0812_20575	COG2205	protein histidine kinase activity
D0812_20605	COG0783	Belongs to the Dps family
D0812_20615	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0812_20620	COG2133	pyrroloquinoline quinone binding
D0812_20625	COG1454	alcohol dehydrogenase
D0812_20630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D0812_20650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0812_20655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0812_20665	COG3186	Phenylalanine-4-hydroxylase
D0812_20700	COG3530	Putative quorum-sensing-regulated virulence factor
D0812_20730	COG0523	cobalamin synthesis protein
D0812_20740	COG0513	Belongs to the DEAD box helicase family
D0812_20760	COG2200	EAL domain
D0812_20765	COG1119	ATPase activity
D0812_20825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0812_20840	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D0812_20845	COG0513	Belongs to the DEAD box helicase family
D0812_20855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0812_20870	COG3278	Belongs to the heme-copper respiratory oxidase family
D0812_20895	COG1024	Enoyl-CoA hydratase
D0812_20900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0812_20905	COG1960	acyl-CoA dehydrogenase activity
D0812_20915	COG0183	Belongs to the thiolase family
D0812_20930	COG1024	Enoyl-CoA hydratase
D0812_20935	COG1024	Enoyl-CoA hydratase
D0812_20945	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_20955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0812_20960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0812_20965	COG1845	cytochrome c oxidase, subunit III
D0812_20970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0812_20980	COG1902	pentaerythritol trinitrate reductase activity
D0812_20980	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0812_20995	COG1012	belongs to the aldehyde dehydrogenase family
D0812_21005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_21070	COG1126	abc transporter atp-binding protein
D0812_21075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_21080	COG4215	(ABC) transporter
D0812_21085	COG4160	amino acid transport
D0812_21090	COG0840	transmembrane signaling receptor activity
D0812_21110	COG3119	arylsulfatase activity
D0812_21115	COG1053	succinate dehydrogenase
D0812_21115	COG0431	NADPH-dependent FMN reductase
D0812_21115	COG3976	FMN-binding domain protein
D0812_21165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0812_21180	COG0443	Heat shock 70 kDa protein
D0812_21185	COG2847	Copper chaperone PCu(A)C
D0812_21215	COG0745	RESPONSE REGULATOR receiver
D0812_21230	COG1785	Belongs to the alkaline phosphatase family
D0812_21255	COG3706	GGDEF domain
D0812_21265	COG0814	amino acid
D0812_21270	COG5002	protein histidine kinase activity
D0812_21270	COG5001	Diguanylate cyclase
D0812_21280	COG0243	molybdopterin cofactor binding
D0812_21310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0812_21310	COG1116	anion transmembrane transporter activity
D0812_21315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0812_21320	COG1116	anion transmembrane transporter activity
D0812_21325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0812_21325	COG2146	nitrite reductase [NAD(P)H] activity
D0812_21375	COG0745	RESPONSE REGULATOR receiver
D0812_21380	COG2205	protein histidine kinase activity
D0812_21380	COG2770	Histidine kinase
D0812_21385	COG4968	Prepilin-type N-terminal cleavage methylation domain
D0812_21405	COG1902	pentaerythritol trinitrate reductase activity
D0812_21415	COG1475	DNA binding
D0812_21435	COG0814	amino acid
D0812_21450	COG1414	Transcriptional regulator
D0812_21460	COG0589	response to stress
D0812_21470	COG2111	Na H antiporter
D0812_21470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0812_21475	COG1006	Multisubunit Na H antiporter MnhC subunit
D0812_21490	COG2212	antiporter activity
D0812_21495	COG1320	monovalent cation:proton antiporter activity
D0812_21500	COG1294	oxidase, subunit
D0812_21505	COG1271	oxidase subunit
D0812_21515	COG0583	DNA-binding transcription factor activity
D0812_21525	COG0739	heme binding
D0812_21560	COG0628	permease
D0812_21600	COG1024	Enoyl-CoA hydratase
D0812_21620	COG0662	Cupin 2, conserved barrel domain protein
D0812_21620	COG2207	Transcriptional regulator
D0812_21690	COG1132	(ABC) transporter
D0812_21715	COG0583	DNA-binding transcription factor activity
D0812_21720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0812_21735	COG2814	Major facilitator Superfamily
D0812_21745	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_21760	COG1196	nuclear chromosome segregation
D0812_21775	COG0509	glycine decarboxylation via glycine cleavage system
D0812_21780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0812_21795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0812_21805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_21810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_21840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0812_21840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_21840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_21845	COG1105	Belongs to the carbohydrate kinase PfkB family
D0812_21850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_21850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_21855	COG1609	Transcriptional regulator
D0812_21870	COG2199	diguanylate cyclase activity
D0812_21870	COG2203	Gaf domain
D0812_21870	COG2200	EAL domain
D0812_21875	COG0765	amino acid transport
D0812_21880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0812_21940	COG5532	Uncharacterized conserved protein (DUF2303)
D0812_21965	COG1484	DNA-dependent DNA replication
D0812_22230	COG0765	amino acid transport
D0812_22235	COG1126	abc transporter atp-binding protein
D0812_22245	COG1979	alcohol dehydrogenase
D0812_22250	COG2207	Transcriptional regulator
D0812_22260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0812_22270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_22285	COG3437	response regulator, receiver
D0812_22285	COG0784	Response regulator, receiver
D0812_22290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_22300	COG0840	transmembrane signaling receptor activity
D0812_22310	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D0812_22315	COG0513	Belongs to the DEAD box helicase family
D0812_22320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0812_22335	COG3038	cytochrome b561
D0812_22345	COG2116	formate transmembrane transporter activity
D0812_22355	COG0583	DNA-binding transcription factor activity
D0812_22365	COG3593	DNA synthesis involved in DNA repair
D0812_22370	COG0737	Belongs to the 5'-nucleotidase family
D0812_22390	COG1410	methionine synthase
D0812_22390	COG0646	methionine synthase
D0812_22405	COG2267	carboxylic ester hydrolase activity
D0812_22425	COG2050	protein possibly involved in aromatic compounds catabolism
D0812_22460	COG0484	heat shock protein binding
D0812_22470	COG3300	MHYT domain
D0812_22470	COG5001	Diguanylate cyclase
D0812_22475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0812_22485	COG4181	ATPase activity
D0812_22490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0812_22500	COG1984	allophanate hydrolase subunit 2
D0812_22505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0812_22515	COG5002	protein histidine kinase activity
D0812_22515	COG3447	MASE1 domain protein
D0812_22515	COG5001	Diguanylate cyclase
D0812_22520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_22535	COG0583	DNA-binding transcription factor activity
D0812_22540	COG0045	succinate-CoA ligase (ADP-forming) activity
D0812_22540	COG1042	CoA-binding domain protein
D0812_22540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_22560	COG0023	Translation Initiation Factor
D0812_22580	COG3140	Belongs to the UPF0181 family
D0812_22605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D0812_22610	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0812_22635	COG3706	GGDEF domain
D0812_22635	COG0745	RESPONSE REGULATOR receiver
D0812_22650	COG5001	Diguanylate cyclase
D0812_22650	COG4251	negative regulation of phosphorylation
D0812_22650	COG3706	GGDEF domain
D0812_22650	COG2203	Gaf domain
D0812_22660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0812_22665	COG4149	molybdate abc transporter
D0812_22670	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0812_22680	COG3111	PFAM Bacterial OB fold (BOF) protein
D0812_22705	COG0534	Mate efflux family protein
D0812_22710	COG0602	queuosine metabolic process
D0812_22715	COG1328	CTP reductase activity
D0812_22800	COG2197	response regulator
D0812_22805	COG3851	Histidine kinase
D0812_22810	COG2271	Major facilitator Superfamily
D0812_22815	COG1482	cell wall glycoprotein biosynthetic process
D0812_22825	COG0628	permease
D0812_22835	COG1566	PFAM secretion protein HlyD family protein
D0812_22865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0812_22870	COG3118	belongs to the thioredoxin family
D0812_22875	COG2814	Major facilitator Superfamily
D0812_22885	COG0534	Mate efflux family protein
D0812_22905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0812_22925	COG2116	formate transmembrane transporter activity
D0812_22930	COG2146	nitrite reductase [NAD(P)H] activity
D0812_22935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0812_22945	COG2199	diguanylate cyclase activity
D0812_23020	COG0277	FAD linked oxidase domain protein
D0812_23025	COG0583	DNA-binding transcription factor activity
D0812_23030	COG1472	Belongs to the glycosyl hydrolase 3 family
D0812_23045	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D0812_23060	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0812_23070	COG1288	antiporter activity
D0812_23080	COG2814	Major facilitator Superfamily
D0812_23090	COG3040	lipid binding
D0812_23130	COG3469	chitinase activity
D0812_23140	COG0419	ATPase involved in DNA repair
D0812_23145	COG0420	3'-5' exonuclease activity
D0812_23170	COG3501	Rhs element vgr protein
D0812_23225	COG0631	protein serine/threonine phosphatase activity
D0812_23260	COG2815	serine threonine protein kinase
D0812_23260	COG0515	serine threonine protein kinase
D0812_23300	COG0346	lactoylglutathione lyase activity
D0812_23305	COG1902	pentaerythritol trinitrate reductase activity
D0812_23315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0812_23315	COG2755	lipolytic protein G-D-S-L family
D0812_23330	COG0069	glutamate synthase activity
D0812_23330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0812_23340	COG1234	tRNA 3'-trailer cleavage
D0812_23345	COG2067	long-chain fatty acid transport protein
D0812_23380	COG2076	Multidrug Resistance protein
D0812_23395	COG0671	phosphoesterase, PA-phosphatase related
D0812_23410	COG2962	Rard protein
D0812_23425	COG0835	chemotaxis
D0812_23425	COG0784	Response regulator, receiver
D0812_23430	COG0778	Nitroreductase
D0812_23440	COG2197	response regulator
D0812_23450	COG3706	GGDEF domain
D0812_23455	COG2197	response regulator
D0812_23460	COG5001	Diguanylate cyclase
D0812_23460	COG3300	MHYT domain
D0812_23465	COG2205	protein histidine kinase activity
D0812_23465	COG0784	Response regulator, receiver
D0812_23480	COG4771	TonB-dependent receptor
D0812_23535	COG1522	sequence-specific DNA binding
D0812_23570	COG0515	serine threonine protein kinase
D0812_23595	COG3501	Rhs element vgr protein
D0812_23610	COG2204	response regulator
D0812_23615	COG2885	chlorophyll binding
D0812_23635	COG0739	heme binding
D0812_23640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0812_23670	COG3069	C4-dicarboxylate transmembrane transporter activity
D0812_23675	COG1704	LemA family
D0812_23680	COG0501	Belongs to the peptidase M48B family
D0812_23710	COG0641	radical SAM
D0812_23730	COG3111	PFAM Bacterial OB fold (BOF) protein
D0812_23735	COG1597	lipid kinase activity
D0812_23750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0812_23760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0812_23820	COG0714	Associated with various cellular activities
D0812_23830	COG3119	arylsulfatase activity
D0812_23835	COG0583	DNA-binding transcription factor activity
D0812_23845	COG3119	arylsulfatase activity
D0812_23850	COG3119	arylsulfatase activity
D0812_23855	COG3119	arylsulfatase activity
D0812_23885	COG2205	protein histidine kinase activity
D0812_23885	COG2198	Histidine kinase
D0812_23885	COG0784	Response regulator, receiver
D0812_23890	COG1879	ABC-type sugar transport system periplasmic component
D0812_23900	COG0210	DNA helicase
D0812_23905	COG1289	transmembrane transporter activity
D0812_23940	COG4206	TonB-dependent receptor
D0812_23950	COG0789	Transcriptional regulator
D0812_23955	COG4604	ABC transporter, ATP-binding protein
D0812_23960	COG4605	iron ion homeostasis
D0812_23965	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_23970	COG4607	ABC-type enterochelin transport system periplasmic component
D0812_23985	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D0812_24000	COG1609	Transcriptional regulator
D0812_24005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_24010	COG1879	ABC-type sugar transport system periplasmic component
D0812_24015	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0812_24020	COG1129	ABC transporter
D0812_24030	COG5001	Diguanylate cyclase
D0812_24035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0812_24040	COG1794	racemase activity, acting on amino acids and derivatives
D0812_24045	COG1051	belongs to the nudix hydrolase family
D0812_24070	COG0586	Pfam SNARE associated Golgi protein
D0812_24090	COG0745	RESPONSE REGULATOR receiver
D0812_24135	COG0583	DNA-binding transcription factor activity
D0812_24145	COG0784	Response regulator, receiver
D0812_24145	COG2205	protein histidine kinase activity
D0812_24155	COG2205	protein histidine kinase activity
D0812_24155	COG0784	Response regulator, receiver
D0812_24160	COG2199	diguanylate cyclase activity
D0812_24160	COG2200	EAL domain
D0812_24160	COG2203	Gaf domain
D0812_24190	COG0330	HflC and HflK could
D0812_24255	COG0529	Catalyzes the synthesis of activated sulfate
D0812_24260	COG3273	potassium ion transport
D0812_24260	COG0471	metal ion transport
D0812_24270	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D0812_24285	COG0438	transferase activity, transferring glycosyl groups
D0812_24305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0812_24310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0812_24315	COG2895	sulfate adenylyltransferase (ATP) activity
D0812_24320	COG0175	sulfate reduction
D0812_24330	COG1596	polysaccharide export
D0812_24335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0812_24340	COG4175	Glycine betaine
D0812_24340	COG0517	IMP dehydrogenase activity
D0812_24345	COG4176	ABC-type proline glycine betaine transport system permease component
D0812_24380	COG3706	GGDEF domain
D0812_24425	COG4580	involved in the transport of maltose and maltodextrins
D0812_24430	COG1874	Beta-galactosidase
D0812_24440	COG3833	ABC-type maltose transport systems, permease component
D0812_24445	COG1175	transmembrane transport
D0812_24450	COG2182	Extracellular solute-binding protein
D0812_24475	COG1609	Transcriptional regulator
D0812_24480	COG2017	converts alpha-aldose to the beta-anomer
D0812_24495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0812_24520	COG0640	Transcriptional regulator
D0812_24550	COG0840	transmembrane signaling receptor activity
D0812_24570	COG0732	type I restriction modification DNA specificity domain
D0812_24575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D0812_24620	COG1061	Type III restriction enzyme res subunit
D0812_24645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0812_24645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0812_24660	COG4989	oxidoreductase activity
D0812_24685	COG1914	H( )-stimulated, divalent metal cation uptake system
D0812_24725	COG2897	thiosulfate sulfurtransferase activity
D0812_24755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0812_24760	COG0840	transmembrane signaling receptor activity
D0812_24765	COG2814	Major facilitator Superfamily
D0812_24770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0812_24785	COG1612	heme a metabolic process
D0812_24805	COG1845	cytochrome c oxidase, subunit III
D0812_24810	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D0812_24825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0812_24835	COG1280	lysine exporter protein (LysE YggA)
D0812_24855	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0812_24870	COG0697	spore germination
D0812_24890	COG2814	Major facilitator Superfamily
D0812_24895	COG0583	DNA-binding transcription factor activity
D0812_24910	COG4774	siderophore transport
D0812_24925	COG1120	ATPase activity
D0812_24930	COG5001	Diguanylate cyclase
D0812_24935	COG0739	heme binding
D0812_24975	COG0814	amino acid
D0812_24995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0812_25000	COG1072	(Pantothenic acid kinase))
D0812_25010	COG1063	alcohol dehydrogenase
D0812_25015	COG2213	PTS system mannitol-specific
D0812_25020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_25025	COG2188	Transcriptional regulator
D0812_25030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0812_25030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_25030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_25035	COG0383	alpha-mannosidase activity
D0812_25040	COG1482	cell wall glycoprotein biosynthetic process
D0812_25050	COG4989	oxidoreductase activity
D0812_25070	COG1733	regulation of RNA biosynthetic process
D0812_25085	COG0798	PFAM Bile acid sodium symporter
D0812_25100	COG1881	PFAM PEBP family protein
D0812_25110	COG0251	oxidation-reduction process
D0812_25115	COG2706	6-phosphogluconolactonase activity
D0812_25130	COG0800	Aldolase
D0812_25135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_25140	COG4145	pantothenate transmembrane transporter activity
D0812_25150	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D0812_25175	COG1131	(ABC) transporter
D0812_25180	COG0842	Transport permease protein
D0812_25195	COG3383	formate dehydrogenase (NAD+) activity
D0812_25220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_25265	COG0494	nUDIX hydrolase
D0812_25280	COG1858	cytochrome C peroxidase
D0812_25290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0812_25300	COG2067	long-chain fatty acid transport protein
D0812_25310	COG1505	serine-type exopeptidase activity
D0812_25315	COG0488	(ABC) transporter
D0812_25320	COG1720	tRNA m6t6A37 methyltransferase activity
D0812_25340	COG0589	response to stress
D0812_25365	COG1175	transmembrane transport
D0812_25370	COG0395	ABC-type sugar transport system, permease component
D0812_25375	COG3842	ATPase activity
D0812_25395	COG1846	Transcriptional regulator
D0812_25415	COG0523	cobalamin synthesis protein
D0812_25425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0812_25435	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_25445	COG1741	Belongs to the pirin family
D0812_25450	COG1278	Cold shock
D0812_25465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0812_25470	COG3706	GGDEF domain
D0812_25495	COG2226	methyltransferase
D0812_25505	COG3706	GGDEF domain
D0812_25510	COG1686	Belongs to the peptidase S11 family
D0812_25515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_25520	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_25530	COG0625	glutathione transferase activity
D0812_25540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0812_25550	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_25575	COG3746	phosphate-selective porin O and P
D0812_25590	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_25600	COG0583	DNA-binding transcription factor activity
D0812_25605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0812_25605	COG2207	Transcriptional regulator
D0812_25610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_25640	COG0513	Belongs to the DEAD box helicase family
D0812_25650	COG0583	DNA-binding transcription factor activity
D0812_25675	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_25680	COG2814	Major facilitator Superfamily
D0812_25690	COG1902	pentaerythritol trinitrate reductase activity
D0812_25705	COG3122	Protein conserved in bacteria
D0812_25710	COG0583	DNA-binding transcription factor activity
D0812_25730	COG0583	DNA-binding transcription factor activity
D0812_25750	COG0252	asparaginase activity
D0812_25760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0812_25760	COG0574	Belongs to the PEP-utilizing enzyme family
D0812_25770	COG2197	response regulator
D0812_25775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0812_25825	COG0583	DNA-binding transcription factor activity
D0812_25830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0812_25845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0812_25850	COG0786	glutamate:sodium symporter activity
D0812_25885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0812_25890	COG0318	PFAM AMP-dependent synthetase and ligase
D0812_25910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_25925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0812_25935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0812_25980	COG1621	beta-fructofuranosidase activity
D0812_25985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_25985	COG1263	PTS System
D0812_25990	COG2188	Transcriptional regulator
D0812_26005	COG4948	Mandelate Racemase Muconate Lactonizing
D0812_26015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0812_26050	COG1342	Belongs to the UPF0251 family
D0812_26060	COG4176	ABC-type proline glycine betaine transport system permease component
D0812_26065	COG3448	diguanylate cyclase activity
D0812_26065	COG4175	Glycine betaine
D0812_26080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0812_26085	COG0583	DNA-binding transcription factor activity
D0812_26135	COG1335	isochorismatase
D0812_26150	COG0753	catalase activity
D0812_26170	COG1482	cell wall glycoprotein biosynthetic process
D0812_26175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_26180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_26180	COG1263	PTS System
D0812_26185	COG1609	Transcriptional regulator
D0812_26190	COG1349	DNA-binding transcription factor activity
D0812_26195	COG0346	lactoylglutathione lyase activity
D0812_26200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_26200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0812_26215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0812_26220	COG3537	Alpha-1,2-mannosidase
D0812_26225	COG3537	Alpha-1,2-mannosidase
D0812_26235	COG3537	Alpha-1,2-mannosidase
D0812_26240	COG3537	Alpha-1,2-mannosidase
D0812_26245	COG0737	Belongs to the 5'-nucleotidase family
D0812_26275	COG1280	lysine exporter protein (LysE YggA)
D0812_26280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0812_26295	COG3226	Transcriptional regulator
D0812_26310	COG0583	DNA-binding transcription factor activity
D0812_26325	COG0488	(ABC) transporter
D0812_26340	COG0431	NADPH-dependent FMN reductase
D0812_26345	COG0583	DNA-binding transcription factor activity
D0812_26350	COG4628	conserved protein (DUF2132)
D0812_26355	COG0488	(ABC) transporter
D0812_26370	COG0346	lactoylglutathione lyase activity
D0812_26375	COG0384	phenazine biosynthesis protein PhzF
D0812_26390	COG3220	belongs to the UPF0276 family
D0812_26405	COG1271	oxidase subunit
D0812_26410	COG1294	oxidase, subunit
D0812_26455	COG2207	Transcriptional regulator
D0812_26470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0812_26475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0812_26490	COG2205	protein histidine kinase activity
D0812_26495	COG0745	RESPONSE REGULATOR receiver
D0812_26505	COG0454	-acetyltransferase
D0812_26510	COG0148	phosphopyruvate hydratase activity
D0812_26520	COG2814	Major facilitator Superfamily
D0812_26535	COG2988	succinylglutamate desuccinylase activity
D0812_26575	COG0628	permease
D0812_26580	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0812_26595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0812_26605	COG4628	conserved protein (DUF2132)
D0812_26610	COG0583	DNA-binding transcription factor activity
D0812_26635	COG1686	Belongs to the peptidase S11 family
D0812_26655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_26660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0812_26685	COG0415	Belongs to the DNA photolyase family
D0812_26690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D0812_26700	COG4667	esterase of the alpha-beta hydrolase superfamily
D0812_26705	COG2095	MarC family integral membrane protein
D0812_26740	COG0583	DNA-binding transcription factor activity
D0812_26745	COG2814	Major facilitator Superfamily
D0812_26775	COG1301	dicarboxylic acid transport
D0812_26780	COG3339	Conserved Protein
D0812_26785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0812_26790	COG0700	Nucleoside recognition
D0812_26795	COG3366	ferrous iron transmembrane transporter activity
D0812_26810	COG0366	Alpha amylase catalytic
D0812_26820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0812_26825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0812_26830	COG1640	4-alpha-glucanotransferase
D0812_26835	COG0058	SHG alpha-glucan phosphorylase activity
D0812_26870	COG1162	GTPase activity
D0812_26875	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D0812_26880	COG0673	inositol 2-dehydrogenase activity
D0812_26905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_26910	COG0673	inositol 2-dehydrogenase activity
D0812_26915	COG3962	Belongs to the TPP enzyme family
D0812_26925	COG0477	Major facilitator Superfamily
D0812_26925	COG2814	Major facilitator Superfamily
D0812_26945	COG0183	Belongs to the thiolase family
D0812_26950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D0812_26975	COG0531	amino acid
D0812_26980	COG1982	Orn Lys Arg decarboxylase major
D0812_27000	COG2356	endonuclease I
D0812_27035	COG2199	diguanylate cyclase activity
D0812_27035	COG2203	Gaf domain
D0812_27055	COG2221	Nitrite and sulphite reductase 4Fe-4S
D0812_27060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0812_27075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_27075	COG1263	PTS System
D0812_27080	COG1028	Short-chain dehydrogenase reductase Sdr
D0812_27085	COG1760	l-serine dehydratase
D0812_27110	COG1609	Transcriptional regulator
D0812_27120	COG2814	Major facilitator Superfamily
D0812_27125	COG3214	Protein conserved in bacteria
D0812_27135	COG4771	TonB-dependent receptor
D0812_27140	COG0583	DNA-binding transcription factor activity
D0812_27145	COG4607	ABC-type enterochelin transport system periplasmic component
D0812_27155	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_27160	COG4605	iron ion homeostasis
D0812_27165	COG4604	ABC transporter, ATP-binding protein
D0812_27195	COG0739	heme binding
D0812_27210	COG0800	Aldolase
D0812_27215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_27220	COG2190	(PTS) system
D0812_27220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_27220	COG1263	PTS System
D0812_27230	COG2188	Transcriptional regulator
D0812_27240	COG1621	beta-fructofuranosidase activity
D0812_27255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0812_27260	COG1554	hydrolase, family 65, central catalytic
D0812_27265	COG0395	ABC-type sugar transport system, permease component
D0812_27300	COG3121	Chaperone
D0812_27305	COG3188	usher protein
D0812_27335	COG0612	Peptidase, M16
D0812_27340	COG0840	transmembrane signaling receptor activity
D0812_27385	COG2842	Transposition protein
D0812_27415	COG3081	Nucleoid-associated protein
D0812_27470	COG3409	Peptidoglycan-binding domain 1 protein
D0812_27470	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0812_27615	COG0667	Aldo Keto reductase
D0812_27625	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0812_27630	COG0666	response to abiotic stimulus
D0812_27635	COG0583	DNA-binding transcription factor activity
D0812_27645	COG1136	(ABC) transporter
D0812_27695	COG1764	response to oxidative stress
D0812_27700	COG1846	Transcriptional regulator
D0812_27705	COG0450	alkyl hydroperoxide reductase
D0812_27710	COG3634	alkyl hydroperoxide reductase activity
D0812_27730	COG2188	Transcriptional regulator
D0812_27735	COG2271	Major facilitator Superfamily
D0812_27740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_27745	COG1397	ADP-ribosylglycohydrolase
D0812_27750	COG2211	Major facilitator Superfamily
D0812_27770	COG0346	lactoylglutathione lyase activity
D0812_27775	COG0840	transmembrane signaling receptor activity
D0812_27785	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D0812_27795	COG1522	sequence-specific DNA binding
D0812_27810	COG2258	MOSC domain
D0812_27815	COG1609	Transcriptional regulator
D0812_27820	COG1757	Na H antiporter
D0812_27825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_27830	COG0513	Belongs to the DEAD box helicase family
D0812_27850	COG1595	DNA-templated transcription, initiation
D0812_27860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0812_27865	COG1312	Catalyzes the dehydration of D-mannonate
D0812_27870	COG2186	Transcriptional regulator
D0812_27880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0812_27890	COG0246	Mannitol dehydrogenase
D0812_27895	COG1904	glucuronate isomerase
D0812_27900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0812_27905	COG0800	Aldolase
D0812_27920	COG0549	Belongs to the carbamate kinase family
D0812_27925	COG0531	amino acid
D0812_27930	COG2957	Belongs to the agmatine deiminase family
D0812_27955	COG1132	(ABC) transporter
D0812_27980	COG0406	alpha-ribazole phosphatase activity
D0812_28075	COG4166	transmembrane transport
D0812_28090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0812_28095	COG1263	PTS System
D0812_28095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0812_28100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0812_28125	COG1444	tRNA N-acetyltransferase activity
D0812_28160	COG4608	Belongs to the ABC transporter superfamily
D0812_28165	COG0444	Belongs to the ABC transporter superfamily
D0812_28175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0812_28175	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D0812_28200	COG0772	Belongs to the SEDS family
D0812_28215	COG1566	PFAM secretion protein HlyD family protein
D0812_28220	COG0583	DNA-binding transcription factor activity
D0812_28230	COG1136	(ABC) transporter
D0812_28250	COG3275	phosphorelay sensor kinase activity
D0812_28255	COG3279	Response regulator of the LytR AlgR family
D0812_28265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0812_28290	COG0786	glutamate:sodium symporter activity
D0812_28305	COG1131	(ABC) transporter
D0812_28310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0812_28315	COG0786	glutamate:sodium symporter activity
D0812_28340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0812_28385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0812_28395	COG2207	Transcriptional regulator
D0812_28400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D0812_28410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0812_28430	COG0251	oxidation-reduction process
D0812_28435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0812_28485	COG0561	phosphatase activity
D0812_28490	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D0812_28495	COG3623	hexulose-6-phosphate isomerase
D0812_28535	COG1741	Belongs to the pirin family
D0812_28540	COG2259	Doxx family
D0812_28550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D0812_28555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0812_28565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0812_28700	COG5001	Diguanylate cyclase
D0812_28705	COG4580	involved in the transport of maltose and maltodextrins
D0812_28710	COG1609	Transcriptional regulator
D0812_28725	COG0395	ABC-type sugar transport system, permease component
D0812_28730	COG2723	6-phospho-beta-galactosidase activity
D0812_28735	COG3842	ATPase activity
D0812_28740	COG1609	Transcriptional regulator
D0812_28745	COG0534	Mate efflux family protein
D0812_28750	COG0564	pseudouridine synthase activity
D0812_28765	COG0561	phosphatase activity
D0812_28775	COG2199	diguanylate cyclase activity
D0812_28785	COG3152	Membrane
D0812_28800	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D0812_28805	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D0812_28820	COG0583	DNA-binding transcription factor activity
D0812_28865	COG2076	Multidrug Resistance protein
D0812_28880	COG1357	PFAM Pentapeptide repeats (8 copies)
D0812_28885	COG3047	cAMP biosynthetic process
D0812_28905	COG2814	Major facilitator Superfamily
D0812_28925	COG3408	Glycogen debranching enzyme
D0812_28925	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0812_28955	COG0583	DNA-binding transcription factor activity
D0812_28995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0812_29030	COG1228	amidohydrolase
D0812_29060	COG1192	Involved in chromosome partitioning
D0812_29090	COG5268	conjugation
D0812_29095	COG3451	type IV secretory pathway VirB4
D0812_29105	COG4962	Type ii secretion system protein e
D0812_29125	COG3504	Conjugal transfer protein
D0812_29135	COG2948	multi-organism process
D0812_29160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0812_29235	COG2801	Transposase and inactivated derivatives
D0812_29260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0812_29340	COG0768	penicillin binding
D0812_29375	COG1192	Involved in chromosome partitioning
D0812_29405	COG1396	sequence-specific DNA binding
D0812_29415	COG5268	conjugation
D0812_29420	COG3451	type IV secretory pathway VirB4
D0812_29430	COG4962	Type ii secretion system protein e
D0812_29490	COG0739	heme binding
D0812_29505	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0812_29525	COG4932	domain protein
D0812_29525	COG5492	domain, Protein
D0812_29550	COG4974	Belongs to the 'phage' integrase family
D0812_29560	COG2337	Toxic component of a toxin-antitoxin (TA) module
D0812_29615	COG2885	chlorophyll binding
D0812_29650	COG4932	domain protein
D0812_29650	COG5492	domain, Protein
D0812_29790	COG4962	Type ii secretion system protein e
D0812_29825	COG3504	Conjugal transfer protein
D0812_29840	COG4962	Type ii secretion system protein e
D0812_29850	COG3451	type IV secretory pathway VirB4
D0812_29855	COG5268	conjugation
D0812_29885	COG1192	Involved in chromosome partitioning
D0812_29910	COG0419	ATPase involved in DNA repair