locus-tag class description DR996_00005 ENOG4105EFV Major head subunit DR996_00020 ENOG4108NYK Tape measure protein DR996_00040 ENOG4105F88 accessory colonization factor AcfD DR996_00065 ENOG4105BZU Histidine kinase DR996_00070 ENOG4105BZU Histidine kinase DR996_00090 ENOG4108UW5 maltose o-acetyltransferase DR996_00120 ENOG4105MSB protein, conserved in bacteria DR996_00125 ENOG4108ZT1 Transcriptional regulator DR996_00135 ENOG4105EIP mannose-6-phosphate isomerase DR996_00170 ENOG4105C8I hydrolase, family 38 DR996_00210 ENOG4108YK4 Acid-resistance membrane protein DR996_00215 ENOG4105CUY Mechanosensitive ion channel DR996_00225 ENOG4108MA4 Peptidase M66 DR996_00230 ENOG4107QHE Choloylglycine hydrolase DR996_00245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DR996_00295 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DR996_00300 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DR996_00305 ENOG4105Q9Y Universal stress protein DR996_00320 ENOG4105ETT transcriptional Regulator, LysR family DR996_00335 ENOG4105E68 Sulfatase DR996_00345 ENOG4105FCK Membrane DR996_00350 ENOG4105CC0 LysR family Transcriptional regulator DR996_00355 ENOG4105ENT Efflux transporter rnd family, mfp subunit DR996_00365 ENOG4105HEI LysR family (Transcriptional regulator DR996_00375 ENOG4105D64 Mechanosensitive ion channel DR996_00525 ENOG4108RXX maleylacetoacetate isomerase DR996_00535 ENOG4105F1J Homogentisate 1,2-dioxygenase DR996_00540 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DR996_00555 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DR996_00560 ENOG4107QSI ABC, transporter DR996_00565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DR996_00570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DR996_00575 ENOG4105C3U ABC transporter DR996_00580 ENOG4108JQ7 (ABC) transporter DR996_00600 ENOG4107MM9 BNR Asp-box repeat-containing protein DR996_00625 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type DR996_00630 ENOG4105D38 putrescine abc transporter DR996_00640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DR996_00645 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DR996_00650 ENOG4105CIF Ornithine Cyclodeaminase DR996_00660 ENOG41080HI glycine oxidase DR996_00665 ENOG4105CTU Proline racemase DR996_00690 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) DR996_00695 ENOG4108VKG metal-dependent hydrolase DR996_00705 ENOG4107VGF ig domain protein group 2 domain protein DR996_00720 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DR996_00795 ENOG4106855 Competence protein DR996_00805 ENOG410624X efflux transporter, rnd family, mfp subunit DR996_00820 ENOG4105F04 LysR family Transcriptional regulator DR996_00845 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) DR996_00850 ENOG4108IU2 vtamin B12-transporter permease DR996_00855 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) DR996_00865 ENOG410902C phosphohistidine phosphatase, SixA DR996_00875 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) DR996_00880 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DR996_00885 ENOG4107XWI flavin reductase domain protein, FMN-binding DR996_00890 ENOG4105K4T epimerase DR996_00895 ENOG4108ETY sodium dicarboxylate symporter DR996_00905 ENOG4105CJB Exodeoxyribonuclease I DR996_00910 ENOG4105VAW lrga family DR996_00915 ENOG41067MG lrgb family DR996_00920 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) DR996_00930 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DR996_00935 ENOG4105FQ6 thiopurine methyltransferase DR996_00945 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DR996_00955 ENOG4105WBN Transcriptional regulator (LacI family DR996_00960 ENOG4105D7K pfkb domain protein DR996_00965 ENOG4107R3K hydrolase DR996_00975 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DR996_00980 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DR996_00985 ENOG4105BZU Histidine kinase DR996_01015 ENOG4105K8R UPF0145 protein DR996_01020 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase DR996_01025 ENOG4105KME endoribonuclease L-psp DR996_01045 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DR996_01050 ENOG41082NX 50s ribosomal protein l35 DR996_01055 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DR996_01060 ENOG4105C22 threonyL-tRNA synthetase DR996_01075 ENOG4105CZE histidine utilization repressor DR996_01080 ENOG4105CI2 imidazolone-5-propionate hydrolase DR996_01085 ENOG41088SP formiminoglutamate hydrolase DR996_01090 ENOG4105CGP Urocanate hydratase DR996_01095 ENOG4105C84 Histidine ammonia-lyase DR996_01110 ENOG4105CQB FAD linked oxidase domain protein DR996_01125 ENOG4105CDV Ompa motb domain protein DR996_01150 ENOG4105C8V SAICAR synthetase DR996_01165 ENOG4105HDD phospholipase DR996_01170 ENOG4105CQ7 ATP-dependent helicase DR996_01175 ENOG4107R1I NAD-dependent malic enzyme DR996_01180 ENOG4107GZ4 SanA protein DR996_01185 ENOG4105C8P )-transporter DR996_01190 ENOG4105BZU Histidine kinase DR996_01210 ENOG4105C3M thioredoxin reductase DR996_01215 ENOG4108JJ9 ABC, transporter DR996_01220 ENOG4108JJ8 (ABC) transporter DR996_01225 ENOG4105BZC d-serine deaminase DR996_01230 ENOG4105W8I Transcriptional regulator DR996_01235 ENOG4105BZU Histidine kinase DR996_01265 ENOG4105BZU Histidine kinase DR996_01275 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DR996_01285 ENOG4105BZU Histidine kinase DR996_01315 ENOG4105DWU Membrane DR996_01325 ENOG4105DY8 decarboxylase DR996_01330 ENOG4106KNT transcriptional regulator DR996_01340 ENOG41090BQ Glutaredoxin DR996_01345 ENOG4105D0C transport protein DR996_01350 ENOG4105RKW reductase (By DR996_01355 ENOG4107QPN acyl-Coa dehydrogenase DR996_01360 ENOG41067SE Tetr family transcriptional regulator DR996_01370 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DR996_01385 ENOG4108I0Y (ABC) transporter DR996_01390 ENOG4107QI1 Mate efflux family protein DR996_01395 ENOG4105CGD Nad-dependent epimerase dehydratase DR996_01400 ENOG4108NRW Phospholipase, patatin family DR996_01410 ENOG4105C2C drug resistance transporter, Bcr CflA DR996_01415 ENOG4105I08 Pseudouridine synthase DR996_01420 ENOG4105CFI type iii restriction protein res subunit DR996_01425 ENOG4108KHP Diguanylate cyclase DR996_01435 ENOG4105ETX regulatoR DR996_01440 ENOG4105EB3 Histidine kinase DR996_01460 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DR996_01475 ENOG4105CGH 5'-nucleotidase DR996_01490 ENOG4105XZD Fe-S protein DR996_01500 ENOG4105CHH sulfate transporter DR996_01510 ENOG4108ZXC Two component transcriptional regulator, luxr family DR996_01515 ENOG4106AFQ Histidine kinase DR996_01525 ENOG4105BZ8 glutamate synthase DR996_01535 ENOG4108RSN SNARE associated Golgi DR996_01540 ENOG4105VNH ABC transporter solute-binding protein DR996_01545 ENOG4105CXZ ABC transporter, permease DR996_01550 ENOG4108VGW abc transporter atp-binding protein DR996_01555 ENOG4108T9J Cdp-alcohol phosphatidyltransferase DR996_01560 ENOG4108JUA Transcriptional regulator DR996_01565 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DR996_01570 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DR996_01580 ENOG4108W1A pseudouridine synthase DR996_01590 ENOG4105C8J )-transporter DR996_01600 ENOG4105C28 cystathionine DR996_01605 ENOG4107IFA Lipase (EC 3.1.1.3) DR996_01615 ENOG4108R3E Dna-3-methyladenine glycosylase i DR996_01635 ENOG4105FM1 phage shock protein C DR996_01640 ENOG4105YYT phage shock protein B DR996_01645 ENOG41087YS Phage shock protein A DR996_01650 ENOG4105E51 psp operon transcriptional activator DR996_01655 ENOG4108J59 Extracellular solute-binding protein, family 5 DR996_01660 ENOG4108I5W peptide transport system, permease protein DR996_01665 ENOG4108EU3 peptide transport system, permease DR996_01670 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein DR996_01675 ENOG4108JQ2 peptide transport system atp-binding protein DR996_01685 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DR996_01700 ENOG4108J2R molybdopterin oxidoreductase DR996_01720 ENOG4105TMB Formate nitrite transporter DR996_01745 ENOG4105GFG DUF218 domain DR996_01750 ENOG4107104 thymidine kinase DR996_01755 ENOG4105C8N cysteinyl-tRNA synthetase DR996_01760 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DR996_01765 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) DR996_01770 ENOG4105D58 Diguanylate phosphodiesterase DR996_01775 ENOG4105K5B UPF0225 protein DR996_01785 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DR996_01805 ENOG4105CIH Imidazole acetol-phosphate transaminase DR996_01815 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DR996_01820 ENOG4107S6Z Na H antiporter DR996_01825 ENOG4108YX2 DNA-binding protein DR996_01830 ENOG4107RE1 Inosine-guanosine kinase DR996_01840 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DR996_01845 ENOG41075W9 High frequency lysogenization protein HflD homolog DR996_01850 ENOG4107QTF adenylosuccinate lyase DR996_01860 ENOG4105RHG DR996_01870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DR996_01885 ENOG4107FW0 short-chain dehydrogenase reductase DR996_01895 ENOG4105D0M Protease HtpX homolog DR996_01905 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DR996_01910 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DR996_01915 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DR996_01920 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DR996_01930 ENOG4105KSC Transcriptional regulator, TraR DksA family DR996_01945 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DR996_01950 ENOG4105D1H recombination factor protein RarA DR996_01955 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) DR996_01960 ENOG4105CNU cell division protein FtsK DR996_01965 ENOG4105EW9 transcriptional regulator AsnC family DR996_01970 ENOG4105DCF alanine dehydrogenase DR996_01980 ENOG4107R11 Transcriptional regulator DR996_01990 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase DR996_02000 ENOG4108UHU Aldolase DR996_02005 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DR996_02010 ENOG4105M5J Cupin 2, conserved barrel domain protein DR996_02015 ENOG4105EY3 heparinase II III family protein DR996_02020 ENOG4105EY3 heparinase II III family protein DR996_02040 ENOG4107QUY Guanine deaminase DR996_02045 ENOG4105KXC Collagenase DR996_02105 ENOG4105X0D Fimbrial protein DR996_02125 ENOG4107EJG GntR family transcriptional regulator DR996_02130 ENOG4105CHR reductase DR996_02135 ENOG4107EJG GntR family transcriptional regulator DR996_02140 ENOG41080XP Cbs domain DR996_02145 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DR996_02150 ENOG4105DFI Membrane DR996_02155 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) DR996_02170 ENOG4107RJ1 sodium solute DR996_02195 ENOG4105E0A ABC, transporter DR996_02200 ENOG4105EHG Permease protein DR996_02205 ENOG4108IHU transport system permease protein DR996_02235 ENOG4105JXH GntR family transcriptional regulator DR996_02245 ENOG4105BZS acriflavin resistance protein DR996_02250 ENOG4105C1P efflux transporter, rnd family, mfp subunit DR996_02265 ENOG4105C8Q Methyl-accepting chemotaxis DR996_02280 ENOG4105DEF Extracellular solute-binding protein, family 5 DR996_02285 ENOG4108JQ7 (ABC) transporter DR996_02290 ENOG4105C3U ABC transporter DR996_02295 ENOG4107R73 Mate efflux family protein DR996_02320 ENOG4105IJJ transcriptional regulator, crp fnr family DR996_02325 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DR996_02330 ENOG4105CS2 ec 3.2.1.21 DR996_02335 ENOG4105C5Y PTS System DR996_02350 ENOG4105ENH Sulfatase DR996_02395 ENOG4105C0D helicase DR996_02435 ENOG4108YGG dna repair protein DR996_02450 ENOG41061A0 Mu-like prophage Flumu protein DR996_02485 ENOG41062PQ Mu-like prophage FluMu protein gp41 DR996_02495 ENOG4105TKZ Tail Sheath DR996_02525 ENOG4105EFV Major head subunit DR996_02545 ENOG4108QUU Morphogenesis Protein DR996_02550 ENOG4105QIB mu-like prophage Flumu protein gp29 DR996_02555 ENOG4105CF2 Mu-like prophage FluMu protein GP28 DR996_02585 ENOG4105ZIA Phage protein gp16 DR996_02665 ENOG4105R8V Transcriptional regulator DR996_02685 ENOG4105JXR Protein of unknown function (DUF3296) DR996_02695 ENOG4108P8R DR996_02700 ENOG410679B prophage CP4-57 regulatory protein alpA DR996_02725 ENOG4105DFP Integrase DR996_02735 ENOG4108RNS Exports L-alanine (By similarity) DR996_02740 ENOG4105BZU Histidine kinase DR996_02750 ENOG4106032 Glutathionylspermidine synthase DR996_02760 ENOG4105Z6B inner membrane protein yjfl DR996_02770 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DR996_02775 ENOG4105UFD tol-pal system protein YbgF DR996_02780 ENOG4105KCK Peptidoglycan-associated lipoprotein DR996_02785 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DR996_02795 ENOG4105M8F Biopolymer transport protein exbD tolR DR996_02800 ENOG4105E02 MotA TolQ exbB proton channel DR996_02805 ENOG4107YD3 Thioesterase DR996_02820 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DR996_02825 ENOG4105C4M (Ubiquinol oxidase) subunit I DR996_02830 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DR996_02835 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DR996_02840 ENOG4105C8Q Methyl-accepting chemotaxis DR996_02845 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) DR996_02850 ENOG4105C9M aspartyl-trna synthetase DR996_02855 ENOG41081XQ Conserved Protein DR996_02860 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) DR996_02865 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) DR996_02875 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DR996_02900 ENOG4105CEY Amp-dependent synthetase and ligase DR996_02905 ENOG4107RGH Aldehyde dehydrogenase DR996_02910 ENOG4108ZX5 transcriptional regulator DR996_02915 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) DR996_02920 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) DR996_02925 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) DR996_02930 ENOG4106371 Methyltransferase DR996_02935 ENOG4107S90 membrAne DR996_02940 ENOG4106WF9 DNA-binding transcriptional regulator TorR DR996_02945 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) DR996_02950 ENOG4105ETE Transcriptional regulator (LacI family DR996_02955 ENOG4105HP8 regulator of competence-specific genes DR996_02975 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DR996_02980 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DR996_02985 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DR996_02990 ENOG4105RKX Protein of unknown function (DUF2498) DR996_02995 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DR996_03005 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) DR996_03010 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate DR996_03015 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DR996_03020 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DR996_03025 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DR996_03030 ENOG4105VEQ Cold shock protein DR996_03040 ENOG4108R99 pseudouridine synthase DR996_03055 ENOG4105DVT helicase DR996_03060 ENOG4105EJ9 Membrane DR996_03065 ENOG4108URS primosomal replication protein n'' DR996_03070 ENOG4106428 Protein of unknown function (DUF2496) DR996_03075 ENOG4105C8Q Methyl-accepting chemotaxis DR996_03080 ENOG4105CGK Exodeoxyribonuclease III DR996_03085 ENOG4108JJ6 Type I secretion system ATPase DR996_03105 ENOG4105DSP amino acid AbC transporter DR996_03110 ENOG4105E89 ABC transporter DR996_03115 ENOG4108JEH abc transporter atp-binding protein DR996_03130 ENOG4105C6N Formate acetyltransferase DR996_03140 ENOG4105F1A Pyruvate formate-lyase DR996_03150 ENOG4105XWI UPF0304 protein DR996_03160 ENOG4105CYN Serine protein kinase DR996_03165 ENOG4106AKX UPF0229 protein DR996_03170 ENOG4105ED1 spovr family DR996_03175 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) DR996_03180 ENOG4105W49 UPF0434 protein DR996_03185 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DR996_03190 ENOG4105BZ1 (ABC) transporter DR996_03195 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 DR996_03205 ENOG4105D60 lipoprotein releasing system transmembrane protein DR996_03210 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DR996_03215 ENOG4105D60 lipoprotein releasing system transmembrane protein DR996_03225 ENOG4108JA2 transcriptioN-repair coupling factor DR996_03240 ENOG4105CEP NADH dehydrogenase DR996_03245 ENOG4105D0Y UPF0227 protein DR996_03270 ENOG4105K59 histidine triad (HIT) protein DR996_03275 ENOG4105C8Q Methyl-accepting chemotaxis DR996_03285 ENOG4107SXA Phosphorylase DR996_03290 ENOG4105C59 p-type ATPase DR996_03300 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DR996_03305 ENOG4105DZ0 fad dependent oxidoreductase DR996_03310 ENOG4108Z4U Ferredoxin DR996_03330 ENOG4108KHX Diguanylate cyclase DR996_03345 ENOG4108MNP Glycoprotein polysaccharide metabolism DR996_03350 ENOG4105C29 acyl-CoA thioesterase DR996_03360 ENOG4108XM1 transcriptional regulator AsnC family DR996_03380 ENOG4105BZS acriflavin resistance protein DR996_03435 ENOG4105HMI Membrane DR996_03445 ENOG4105W8I Transcriptional regulator DR996_03450 ENOG4105CI1 PTS System DR996_03455 ENOG4105CEY Amp-dependent synthetase and ligase DR996_03465 ENOG4108IPT Naphthoate synthase DR996_03470 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DR996_03475 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DR996_03480 ENOG4105E4F Isochorismate synthase DR996_03485 ENOG4105CHM Aminotransferase DR996_03490 ENOG4105DK2 UPF0207 protein DR996_03495 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein DR996_03510 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein DR996_03515 ENOG4105EIN peptidylprolyl cis-trans isomerase DR996_03520 ENOG4105K70 DNA-binding protein DR996_03525 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DR996_03530 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DR996_03535 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DR996_03540 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DR996_03545 ENOG4105CQZ Histidine kinase DR996_03550 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_03560 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DR996_03565 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ DR996_03570 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DR996_03575 ENOG4105CNG UPF0061 protein DR996_03595 ENOG4107ZYR domain protein DR996_03600 ENOG4105C94 Transporter DR996_03605 ENOG4105C1J atp-dependent rna helicase DR996_03615 ENOG4105D05 Receptor DR996_03630 ENOG4105CEY Amp-dependent synthetase and ligase DR996_03630 ENOG4105CEY Amp-dependent synthetase and ligase DR996_03635 ENOG4105WQI isochorismatase DR996_03640 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DR996_03645 ENOG4105E4F Isochorismate synthase DR996_03655 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DR996_03665 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DR996_03675 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DR996_03680 ENOG4105D9N nucleoside DR996_03685 ENOG4105EQ2 LysR family Transcriptional regulator DR996_03690 ENOG4105CVE Lytic murein transglycosylase DR996_03695 ENOG4105VNG YcgL domain-containing protein DR996_03700 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DR996_03705 ENOG4107QMS site-determining protein DR996_03710 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) DR996_03715 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) DR996_03720 ENOG4105CEY Amp-dependent synthetase and ligase DR996_03725 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DR996_03730 ENOG4105R8X Outer membrane lipoprotein Slp DR996_03740 ENOG41072GX Peptidase M22 Glycoprotease DR996_03745 ENOG4105DVT helicase DR996_03750 ENOG4105CIY formyltetrahydrofolate deformylase DR996_03755 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap DR996_03765 ENOG4106ZCM YecM protein DR996_03775 ENOG4105C75 arginyL-tRNA synthetase DR996_03795 ENOG4105XFK Ferrous iron transport protein A DR996_03800 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) DR996_03805 ENOG4105NXV High-affinity zinc uptake system protein DR996_03810 ENOG4105FDK ABC transporter DR996_03815 ENOG4105FAV ABC, transporter DR996_03820 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DR996_03825 ENOG4105CMV Succinyl-CoA synthetase subunit beta DR996_03830 ENOG4105C7S Dehydrogenase DR996_03835 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DR996_03840 ENOG4105E33 succinate dehydrogenase DR996_03845 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) DR996_03850 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein DR996_03855 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit DR996_03860 ENOG4105BZN citrate synthase DR996_03865 ENOG4107QNR UPF0135 protein DR996_03880 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 DR996_03885 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) DR996_03890 ENOG4105EV9 Alpha Beta Hydrolase DR996_03900 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) DR996_03910 ENOG41090R7 Ferric uptake DR996_03915 ENOG4108VAU general secretion pathway protein G DR996_03920 ENOG4105CX6 glutaminyL-tRNA synthetase DR996_03925 ENOG4105CI1 PTS System DR996_03935 ENOG4105CE4 GlcNAc 6-P deacetylase DR996_03940 ENOG4105E2R ROK family DR996_03945 ENOG4105CKD glutathione-regulated potassium-efflux system protein DR996_03950 ENOG4105CAQ asparagine synthetase DR996_03955 ENOG4105MDZ Transcriptional activator rfaH DR996_03960 ENOG4105DUX Transporter DR996_03965 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DR996_03970 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DR996_03975 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DR996_03980 ENOG4108DQ1 activator toxR DR996_04000 ENOG4108RE9 Phosphodiesterase DR996_04030 ENOG4105ECP epimerase DR996_04035 ENOG4105E1F short-chain dehydrogenase reductase DR996_04045 ENOG4107QR8 Thioredoxin DR996_04055 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) DR996_04060 ENOG4107EEX Cellulose synthase regulator protein DR996_04065 ENOG4107QZ7 Cellulose synthase catalytic subunit DR996_04085 ENOG4105D1V cellulose synthase operon protein YhjU DR996_04090 ENOG4107QX8 SPFH domain, Band 7 family protein DR996_04120 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DR996_04130 ENOG4105EXN Sulfate transport protein CysZ DR996_04135 ENOG4105C6T cysteine synthase DR996_04145 ENOG4105KZ7 phosphocarrier protein hpr DR996_04150 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DR996_04155 ENOG4105C5Y PTS System DR996_04165 ENOG4105I03 Flagellin DR996_04170 ENOG4105I03 Flagellin DR996_04185 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DR996_04190 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DR996_04195 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DR996_04200 ENOG4105CGA flagellar basal-body rod protein FlgG DR996_04205 ENOG4108KPB Flagellar basal-body rod protein FlgF DR996_04210 ENOG4105BZE flagellar hook protein, FlgE DR996_04215 ENOG4105W00 Flagellar hook capping protein DR996_04220 ENOG4108ZC9 flagellar basal-body rod protein flgc DR996_04225 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DR996_04230 ENOG4105BZU Histidine kinase DR996_04235 ENOG4107R88 Chemotaxis protein (CheV) DR996_04280 ENOG4105UYK outer membrane protein a DR996_04285 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DR996_04295 ENOG41081QG Porin Gram-negative type DR996_04305 ENOG4105C59 p-type ATPase DR996_04320 ENOG4105E2D ec 3.2.1.52 DR996_04340 ENOG4108DG9 Smr protein MutS2 DR996_04345 ENOG4105FE9 pseudouridine synthase DR996_04350 ENOG4108Z66 YbaK ebsC protein DR996_04355 ENOG4105CGH 5'-nucleotidase DR996_04360 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DR996_04365 ENOG41063JG Transcriptional regulator DR996_04370 ENOG4108YY7 Invasion gene expression up-regulator SirB DR996_04375 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DR996_04380 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DR996_04385 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DR996_04395 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DR996_04400 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DR996_04405 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DR996_04410 ENOG4105C3G gtp-binding protein DR996_04530 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DR996_04540 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DR996_04545 ENOG4105C9A Phoh family DR996_04550 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DR996_04555 ENOG4108JU5 Magnesium and cobalt efflux protein DR996_04560 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DR996_04565 ENOG4107PAI alpha helical protein DR996_04570 ENOG4105C8T Leucyl-tRNA synthetase DR996_04575 ENOG4108U2H Rare lipoprotein B DR996_04580 ENOG4105DJF DNA polymerase III, delta' subunit DR996_04585 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) DR996_04590 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DR996_04595 ENOG4105CJN penicillin-binding protein DR996_04600 ENOG4105CNI cell division protein FtsW DR996_04605 ENOG4105K6T rare lipoprotein A DR996_04610 ENOG4105DZ1 carboxypeptidase DR996_04615 ENOG4108Z43 UPF0250 protein DR996_04620 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DR996_04625 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DR996_04630 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DR996_04635 ENOG4108JYZ YitT family DR996_04650 ENOG4105CG3 alpha amylase, catalytic region DR996_04655 ENOG4105C5Y PTS System DR996_04660 ENOG4105D4X repressor DR996_04665 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DR996_04670 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DR996_04675 ENOG4108UMI ABC transporter, permease DR996_04680 ENOG4105D01 (LipO)protein DR996_04690 ENOG4105CGH 5'-nucleotidase DR996_04695 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein DR996_04700 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) DR996_04705 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DR996_04720 ENOG4105EWT decarboxylase family DR996_04725 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease DR996_04730 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) DR996_04735 ENOG4105M08 Membrane DR996_04745 ENOG4105ETT transcriptional Regulator, LysR family DR996_04750 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) DR996_04755 ENOG4106VK6 Flagellar motor protein DR996_04755 ENOG4106VK6 Flagellar motor protein DR996_04760 ENOG4105E14 MotA TolQ exbB proton channel DR996_04765 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DR996_04770 ENOG4105CTB Polyprenyl synthetase DR996_04775 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DR996_04780 ENOG4108ZAI phosphatidylglycerophosphatase a DR996_04785 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DR996_04790 ENOG4107YIM Involved in the transcription termination process (By similarity) DR996_04795 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DR996_04810 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DR996_04815 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DR996_04820 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DR996_04825 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DR996_04830 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) DR996_04835 ENOG4108DJV Fermentation respiration switch protein DR996_04840 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) DR996_04845 ENOG4105C7N Xanthine uracil vitamin C permease DR996_04850 ENOG4105CIN aminoacyl-histidine dipeptidase DR996_04880 ENOG4108ETH Formylglycinamide ribotide synthetase DR996_04885 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) DR996_04895 ENOG4108Z6B deaminase DR996_04900 ENOG4105CFC Transporter DR996_04940 ENOG4105CFG Acts as a chaperone (By similarity) DR996_04955 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DR996_04960 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DR996_04970 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DR996_04975 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase DR996_04980 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DR996_04990 ENOG4105VDB UPF0125 protein DR996_04995 ENOG4108Z1B Cyclase dehydrase DR996_05000 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DR996_05010 ENOG4105ETT transcriptional Regulator, LysR family DR996_05015 ENOG410613R integral membrane protein, YccS YhfK family DR996_05035 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DR996_05040 ENOG4108IQK o-acetylhomoserine DR996_05055 ENOG4107RSM transcriptional regulator DR996_05060 ENOG4105MWK D-amino acid dehydrogenase, small subunit DR996_05065 ENOG4105BZG amino acid carrier protein DR996_05070 ENOG4106HK8 GPR1 FUN34 yaaH family protein DR996_05080 ENOG4107S6Z Na H antiporter DR996_05085 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DR996_05090 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DR996_05095 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DR996_05105 ENOG410620I Diguanylate cyclase DR996_05115 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DR996_05120 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DR996_05125 ENOG4105N21 Membrane DR996_05130 ENOG4105CUT histidyl-tRNA synthetase DR996_05135 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DR996_05145 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DR996_05150 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DR996_05155 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DR996_05160 ENOG4105WVQ Fe-S assembly protein IscX DR996_05165 ENOG4108ZIT Ferredoxin, 2FE-2S DR996_05170 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB DR996_05175 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) DR996_05180 ENOG4108Z4V iron-sulfur cluster assembly DR996_05185 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins DR996_05190 ENOG4105C3J Cysteine desulfurase DR996_05195 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family DR996_05200 ENOG4105CVS RNA methyltransferase TrmH family, group 1 DR996_05205 ENOG4105ECY inositol monophosphatase DR996_05210 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DR996_05215 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DR996_05220 ENOG4105VIE preprotein translocase, subunit YajC DR996_05225 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DR996_05230 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DR996_05245 ENOG4105W87 Cbs domain DR996_05250 ENOG4108I9X Isocitrate lyase DR996_05255 ENOG4107QP3 malate synthase g DR996_05260 ENOG4105C5Q Transcriptional regulator DR996_05265 ENOG4105D3R alkyl hydroperoxide reductase DR996_05270 ENOG4106N3A copper homeostasis protein cutc DR996_05275 ENOG4105CSR polyphosphate kinase 2 DR996_05300 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DR996_05305 ENOG4105E2Z phosphate ABC transporter (Permease DR996_05310 ENOG4105C8U phosphate abc transporter DR996_05315 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DR996_05320 ENOG4105C9X ppx gppa phosphatase DR996_05325 ENOG4105DJH phosphate DR996_05330 ENOG4105BZU Histidine kinase DR996_05335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DR996_05340 ENOG4105DH7 May be involved in recombination (By similarity) DR996_05345 ENOG4105CFP Peptidase U32 DR996_05350 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DR996_05375 ENOG4105CEE C4-dicarboxylate transporter DR996_05380 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DR996_05410 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DR996_05495 ENOG4105CS6 Rhs element vgr protein DR996_05505 ENOG4108WC9 type VI secretion system effector, hcp1 family DR996_05535 ENOG4108JUB Transcriptional regulator DR996_05540 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DR996_05650 ENOG4108YGG dna repair protein DR996_05655 ENOG4108QDQ Ubiquinol-cytochrome C chaperone DR996_05665 ENOG4105DFP Integrase DR996_05705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DR996_05710 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DR996_05715 ENOG4105C34 Pseudouridine synthase DR996_05720 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DR996_05725 ENOG4105E4C Lytic transglycosylase catalytic DR996_05730 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA DR996_05740 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DR996_05745 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) DR996_05750 ENOG4107SC1 transglycosylase DR996_05755 ENOG4105C5H ABC transporter DR996_05765 ENOG4105DR5 peptidase DR996_05770 ENOG4105EHE chorismate mutase- prephenate dehydrogenase DR996_05775 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DR996_05785 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DR996_05790 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DR996_05810 ENOG4108HRK Histidine kinase DR996_05815 ENOG4108NEV two component transcriptional regulator, LytTR family DR996_05820 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DR996_05825 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase DR996_05830 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DR996_05835 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DR996_05840 ENOG4105DTN riboflavin biosynthesis protein ribF DR996_05845 ENOG4105CJR Integral membrane protein (MviN DR996_05850 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DR996_05855 ENOG41080HT Transcriptional regulator, arsr family DR996_05860 ENOG41063Z6 transcriptional regulator, lysR family DR996_05870 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DR996_05875 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DR996_05880 ENOG4105HF0 Membrane DR996_05885 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase DR996_05890 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DR996_05895 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) DR996_05905 ENOG4105CPC Aldo Keto reductase DR996_05915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_05920 ENOG4105CRK lysyL-tRNA synthetase DR996_05930 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DR996_05935 ENOG4105T95 Thiol disulfide interChange protein DR996_05945 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) DR996_05950 ENOG4105CWM branched-chain amino acid transport system II carrier protein DR996_05955 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) DR996_05960 ENOG4105C1J atp-dependent rna helicase DR996_05970 ENOG4105D1Q UPF0246 protein DR996_05975 ENOG4105BZG amino acid carrier protein DR996_05990 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DR996_06000 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DR996_06005 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) DR996_06010 ENOG4108YYH Nadph-dependent fmn reductase DR996_06015 ENOG4105D98 threonine synthase DR996_06020 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DR996_06035 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) DR996_06050 ENOG41065U4 response regulator DR996_06060 ENOG4105BZU Histidine kinase DR996_06070 ENOG4105N5T Radical SAM Protein DR996_06085 ENOG4105CBC glutamate synthase DR996_06090 ENOG4105BZ8 glutamate synthase DR996_06100 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DR996_06110 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DR996_06115 ENOG4105EN6 Membrane DR996_06120 ENOG4105VP0 transcriptional regulator, lysR family DR996_06125 ENOG4105EJ9 Membrane DR996_06145 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DR996_06150 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DR996_06155 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DR996_06160 ENOG4105M6F mutator MutT protein DR996_06165 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DR996_06175 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DR996_06180 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DR996_06185 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DR996_06190 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) DR996_06195 ENOG4105DFU Cell wall formation (By similarity) DR996_06200 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DR996_06210 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DR996_06215 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DR996_06220 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) DR996_06225 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DR996_06230 ENOG4105CJN penicillin-binding protein DR996_06235 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DR996_06240 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DR996_06255 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DR996_06265 ENOG41082RQ UPF0102 protein DR996_06270 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DR996_06275 ENOG4105W4M Transport-associated protein DR996_06280 ENOG4105KB2 stringent starvation protein b DR996_06285 ENOG4107MKT Stringent starvation protein a DR996_06290 ENOG4105EIX cytochrome c1 DR996_06295 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DR996_06300 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DR996_06305 ENOG4108UJD 30S ribosomal protein S9 DR996_06310 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DR996_06320 ENOG4105D6Z AFG1 family ATPase DR996_06330 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III DR996_06335 ENOG4105C0H protease DR996_06340 ENOG4105C0H protease DR996_06345 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DR996_06350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DR996_06355 ENOG4105IPS esterase DR996_06360 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DR996_06365 ENOG4108SX3 cytoplasmic protein DR996_06370 ENOG41087AY ADP-Ribose pyrophosphatase DR996_06375 ENOG4105DFG type I secretion outer membrane protein DR996_06380 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DR996_06385 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DR996_06390 ENOG4105C8Q Methyl-accepting chemotaxis DR996_06400 ENOG4105I7R Adenylate cyclase DR996_06405 ENOG4107IX6 phosphate transport regulator DR996_06410 ENOG4105CJ3 phosphate transporter DR996_06415 ENOG4106MWK domain protein DR996_06420 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DR996_06440 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DR996_06445 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DR996_06450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DR996_06455 ENOG4107ZVW dihydroneopterin aldolase DR996_06460 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DR996_06465 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DR996_06470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DR996_06475 ENOG4105VCC 30S ribosomal protein S21 DR996_06480 ENOG4105KTH gatB Yqey DR996_06485 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DR996_06490 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DR996_06520 ENOG4105CTS PTS system mannitol-specific DR996_06525 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase DR996_06530 ENOG4105E61 Mannitol repressor protein DR996_06535 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DR996_06540 ENOG4105GR3 Histidine kinase DR996_06560 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DR996_06565 ENOG410804X Transcriptional regulator DR996_06575 ENOG4105CA9 Pyruvate kinase DR996_06585 ENOG4105BZU Histidine kinase DR996_06590 ENOG4108ZP8 Acetolactate synthase small subunit DR996_06595 ENOG4105C7K acetolactate synthase DR996_06600 ENOG4108IQE Amp-dependent synthetase and ligase DR996_06605 ENOG41064T2 transcriptional regulator, lysR family DR996_06635 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DR996_06640 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DR996_06645 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DR996_06650 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DR996_06660 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) DR996_06665 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) DR996_06670 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DR996_06675 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DR996_06680 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DR996_06685 ENOG4105NWN ApaG protein DR996_06690 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DR996_06695 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DR996_06705 ENOG4107XM3 UPF0442 protein DR996_06710 ENOG4105DWK Membrane DR996_06715 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DR996_06720 ENOG4105K46 50S ribosomal protein l27 DR996_06725 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DR996_06730 ENOG4105EAH synthase DR996_06740 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DR996_06745 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) DR996_06755 ENOG4105H1G trap transporter solute receptor taxi family DR996_06770 ENOG4107T0D ABC, transporter DR996_06775 ENOG4106SMU thiamine transporter membrane protein DR996_06780 ENOG4105DP9 ABC transporter DR996_06785 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DR996_06790 ENOG4105DFU Cell wall formation (By similarity) DR996_06795 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 DR996_06800 ENOG4105F0N pyrophosphate phospho-hydrolase DR996_06815 ENOG41066HZ AIG2-like family DR996_06820 ENOG4105MA0 exported protein DR996_06825 ENOG4105CFU surface antigen DR996_06830 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DR996_06840 ENOG4108UUE Transcriptional regulator DR996_06855 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DR996_06875 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DR996_06885 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) DR996_06890 ENOG4105C11 sulfate adenylyltransferase), subunit 2 DR996_06895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DR996_06900 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic DR996_06915 ENOG4105C1J atp-dependent rna helicase DR996_06920 ENOG4107YB6 acetyltransferase, (GNAT) family DR996_06935 ENOG4108V1T peptidylprolyl cis-trans isomerase DR996_06945 ENOG4108ZT0 50S ribosomal protein l17 DR996_06950 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DR996_06955 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DR996_06960 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DR996_06965 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DR996_06975 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DR996_06980 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DR996_06985 ENOG4105VPB 50S ribosomal protein L30 DR996_06990 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DR996_07000 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DR996_07010 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DR996_07015 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DR996_07020 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DR996_07025 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DR996_07030 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DR996_07035 ENOG41083MP 50s ribosomal protein l29 DR996_07040 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DR996_07045 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DR996_07050 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DR996_07060 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DR996_07065 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DR996_07070 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DR996_07075 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DR996_07080 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DR996_07085 ENOG4105VFB Binds the 23S rRNA (By similarity) DR996_07095 ENOG4105C25 Primosomal protein n' DR996_07100 ENOG4105ETE Transcriptional regulator (LacI family DR996_07110 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DR996_07115 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DR996_07120 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DR996_07125 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) DR996_07130 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) DR996_07135 ENOG4105CBT Fructose-1,6-bisphosphatase DR996_07160 ENOG4105CP7 Triose-phosphate isomerase DR996_07165 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DR996_07185 ENOG4105EIP mannose-6-phosphate isomerase DR996_07190 ENOG4106ECQ phosphomannomutase DR996_07195 ENOG4107S6X Glycosyl transferase, family 2 DR996_07200 ENOG4105CJT Mannose-1-phosphate guanylyltransferase DR996_07205 ENOG4105FGF GDP-mannose mannosyl hydrolase DR996_07210 ENOG4105C30 Nad-dependent epimerase dehydratase DR996_07215 ENOG4105C0K Gdp-mannose 4,6-dehydratase DR996_07255 ENOG4105ESV Glycosyl transferase, family 4 DR996_07275 ENOG4105EXC Acyl-transferase DR996_07290 ENOG4105JEU Glycosyl transferase, family 2 DR996_07320 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DR996_07325 ENOG4105C1B dTDP-glucose 4-6-dehydratase DR996_07335 ENOG4105DAY polysaccharide export protein DR996_07360 ENOG4105E3R (LipO)protein DR996_07365 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DR996_07370 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase DR996_07375 ENOG4105XA0 heptosyltransferase ii DR996_07380 ENOG4107TYR Glycosyl Transferase DR996_07385 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase DR996_07395 ENOG4105TWJ Domain of unknown function (DUF1919) DR996_07400 ENOG4107QK7 reductase DR996_07405 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DR996_07410 ENOG4105FAW cDP-glucose 4,6-dehydratase DR996_07415 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DR996_07420 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DR996_07435 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) DR996_07440 ENOG4105DKP glycosyl transferase, family 9 DR996_07445 ENOG4106WTF Glycosyl transferase, family 2 DR996_07455 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DR996_07460 ENOG4108JMC lipopolysaccharide core biosynthesis protein DR996_07465 ENOG41080IJ Diacylglycerol kinase DR996_07470 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DR996_07485 ENOG4105KDC 50s ribosomal protein l28 DR996_07490 ENOG4105W5Q DNA repair protein (RadC DR996_07495 ENOG4105C8Q Methyl-accepting chemotaxis DR996_07505 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DR996_07510 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) DR996_07515 ENOG4105D1S lipid A biosynthesis DR996_07520 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DR996_07525 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DR996_07530 ENOG4105DSJ YicC domain protein DR996_07535 ENOG4108M3R transcriptional activator CadC DR996_07545 ENOG4105DWP Membrane DR996_07560 ENOG4108JQ7 (ABC) transporter DR996_07570 ENOG4107QRA Extracellular solute-binding protein, family 5 DR996_07575 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component DR996_07580 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component DR996_07610 ENOG4109015 Biopolymer transport protein exbD tolR DR996_07625 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DR996_07630 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) DR996_07635 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DR996_07640 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase DR996_07645 ENOG4105CB5 ATP-dependent DNA helicase recG DR996_07650 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DR996_07655 ENOG4105C2W permease DR996_07660 ENOG4105E0F Histidine kinase DR996_07670 ENOG4108RRZ Transcription elongation factor GreB DR996_07680 ENOG4105BZM domain protein DR996_07690 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DR996_07695 ENOG4105MJ2 Competence protein DR996_07700 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) DR996_07705 ENOG4107RK2 ADP-ribose diphosphatase NudE DR996_07710 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase DR996_07715 ENOG4105PIC general secretion pathway protein N DR996_07720 ENOG4105U1E general secretion pathway protein M DR996_07725 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) DR996_07730 ENOG4108RTD type II secretion system protein K DR996_07735 ENOG4108WWZ General secretion pathway protein J DR996_07740 ENOG4105X5Z General secretion pathway protein I DR996_07745 ENOG4105VWV general secretion pathway protein h DR996_07750 ENOG4108VAU general secretion pathway protein G DR996_07755 ENOG4105D7Q type ii secretion system DR996_07760 ENOG4107QHF type ii secretion system protein e DR996_07770 ENOG4108XKW General secretion pathway protein C DR996_07775 ENOG4105VEJ Heat shock protein DR996_07780 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DR996_07785 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DR996_07795 ENOG4105SUU thioesterase domain DR996_07800 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DR996_07805 ENOG4107S2Z UPF0761 membrane protein DR996_07820 ENOG4105CI3 gtp-binding protein typa DR996_07830 ENOG4105C5F glutamine synthetase DR996_07840 ENOG4105CUX Signal transduction histidine kinase DR996_07845 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_07850 ENOG4105BZU Histidine kinase DR996_07855 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DR996_07860 ENOG4105D4P Coproporphyrinogen iii oxidase DR996_07865 ENOG4105XCT Protein of unknown function (DUF2489) DR996_07870 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) DR996_07890 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DR996_07900 ENOG4105C2M dna polymerase I DR996_07915 ENOG4105D52 delta-aminolevulinic acid dehydratase DR996_07920 ENOG4105F8V Hydrolase, tatD family DR996_07925 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DR996_07935 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DR996_07940 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DR996_07945 ENOG4105JC1 sterol-binding domain protein DR996_07955 ENOG4105CGY Dna recombination protein DR996_07965 ENOG4105BZU Histidine kinase DR996_08035 ENOG4106K8T Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA DR996_08060 ENOG4105D70 Integrase catalytic subunit DR996_08065 ENOG4105F5W AtP-binding protein DR996_08080 ENOG4105CBX hi0933 family DR996_08110 ENOG4108V6B universal stress protein B DR996_08115 ENOG41090A1 ferritin DR996_08120 ENOG4108M6U Universal stress protein A DR996_08125 ENOG4105EMK carboxylate amino acid amine transporter DR996_08135 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) DR996_08140 ENOG4105BZU Histidine kinase DR996_08145 ENOG4108VVK transcriptional Regulator, AsnC DR996_08150 ENOG4105DGW oligopeptidase A DR996_08160 ENOG4105D6S protein involved in catabolism of external DNA DR996_08170 ENOG4105DC8 reductase DR996_08200 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) DR996_08215 ENOG4105CS6 Rhs element vgr protein DR996_08250 ENOG4108UHU Aldolase DR996_08255 ENOG4105C6Z Gluconate DR996_08260 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family DR996_08265 ENOG4105C01 Dihydroxy-acid dehydratase DR996_08275 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) DR996_08280 ENOG41064T2 transcriptional regulator, lysR family DR996_08285 ENOG4105DIQ Transcriptional regulator DR996_08320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DR996_08325 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DR996_08335 ENOG4108JQ6 ABC transporter DR996_08370 ENOG4105C7H Helicase, RecD TraA family DR996_08375 ENOG4105EKQ RNA-directed DNA polymerase DR996_08385 ENOG4107QUY Guanine deaminase DR996_08535 ENOG4105CVR type I restriction-modification system DR996_08540 ENOG41082EK Restriction modification system DNA (Specificity DR996_08555 ENOG4105DZR Type I site-specific deoxyribonuclease DR996_08585 ENOG4105MPD Cytochrome DR996_08590 ENOG4105C4R Atp-dependent dna helicase DR996_08595 ENOG4107Z3H Transcriptional regulator, TetR family DR996_08600 ENOG410624X efflux transporter, rnd family, mfp subunit DR996_08605 ENOG4105BZS acriflavin resistance protein DR996_08615 ENOG4105W0Z cytoplasmic protein DR996_08630 ENOG4105EMY transcriptional regulator DR996_08675 ENOG4108Z0R Transferase DR996_08680 ENOG4105SG3 Protein of unknown function (DUF1488) DR996_08685 ENOG4105E2X shikimate dehydrogenase DR996_08690 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) DR996_08695 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DR996_08700 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DR996_08705 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DR996_08710 ENOG4108WI1 Dna topoisomerase DR996_08715 ENOG4108RPN Protein smg homolog DR996_08720 ENOG4105C79 DNA protecting protein DprA DR996_08735 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DR996_08740 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DR996_08745 ENOG4105C1A potassium transporter peripheral membrane DR996_08750 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) DR996_08760 ENOG4108UT2 hemolysin iii DR996_08765 ENOG4108N23 SpoOM-related protein DR996_08775 ENOG4105PC1 Conserved Protein DR996_08785 ENOG4105E27 serine threonine protein kinase DR996_08790 ENOG4108Z33 Thiol disulfide Interchange Protein DR996_08795 ENOG4106HNH Acyl-transferase DR996_08860 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DR996_08865 ENOG4105C0P Mg chelatase subunit ChlI DR996_08875 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit DR996_08880 ENOG4105CM2 brancheD-chain amino acid aminotransferase DR996_08885 ENOG4105C01 Dihydroxy-acid dehydratase DR996_08890 ENOG4105C7B Threonine dehydratase DR996_08895 ENOG4106TD9 Diguanylate cyclase DR996_08900 ENOG4105F52 Transcriptional regulator DR996_08905 ENOG4105CZQ inner membrane transport protein YdhC DR996_08915 ENOG4105EAD ABC transporter DR996_08920 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DR996_08925 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DR996_08930 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DR996_08935 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DR996_08940 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DR996_08945 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DR996_08950 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DR996_08960 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) DR996_08965 ENOG410684E atp synthase DR996_08970 ENOG4105FA0 parb-like partition protein DR996_08975 ENOG4107QJE Chromosome Partitioning Protein DR996_08980 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DR996_08985 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DR996_08990 ENOG4105QTB Flavodoxin DR996_08995 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DR996_09000 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DR996_09010 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DR996_09020 ENOG4105CDA abc transporter atp-binding protein DR996_09025 ENOG4105E5Q amino acid AbC transporter DR996_09030 ENOG4105EAB amino acid AbC transporter DR996_09040 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DR996_09045 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DR996_09050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DR996_09055 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DR996_09060 ENOG4108ZNX Heat shock protein DR996_09065 ENOG4105JKW Valine--pyruvate aminotransferase DR996_09070 ENOG4107T9C Alpha amylase catalytic region DR996_09075 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DR996_09080 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DR996_09095 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DR996_09110 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family DR996_09115 ENOG4105CHU acetyl-coa acetyltransferase DR996_09120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DR996_09125 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DR996_09130 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) DR996_09135 ENOG4108RR8 protoporphyrinogen oxidase DR996_09185 ENOG4105E3B Multicopper oxidase DR996_09190 ENOG4105WMR Protein CrcB homolog DR996_09195 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DR996_09205 ENOG4105D06 uba thif-type nad fad binding protein DR996_09210 ENOG4105WHD thiamine biosynthesis protein ThiS DR996_09215 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DR996_09220 ENOG4105D41 biosynthesis protein thiH DR996_09225 ENOG4105DC7 peptidase M24 DR996_09225 ENOG4105DC7 peptidase M24 DR996_09230 ENOG4105G2Y Transcriptional regulator DR996_09235 ENOG4105CNH Multidrug resistance protein MdtL DR996_09255 ENOG4105E18 UPF0276 protein DR996_09265 ENOG4105C4R Atp-dependent dna helicase DR996_09275 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DR996_09280 ENOG4105CCF Lysine exporter protein (Lyse ygga) DR996_09290 ENOG4105FR1 rard protein DR996_09295 ENOG4105C9U ATP-dependent DNA helicase RecQ DR996_09305 ENOG4105EX9 Membrane DR996_09315 ENOG4105C9X ppx gppa phosphatase DR996_09320 ENOG4105C1J atp-dependent rna helicase DR996_09330 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DR996_09340 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DR996_09345 ENOG4108ZIT Ferredoxin, 2FE-2S DR996_09350 ENOG4107QK7 reductase DR996_09395 ENOG4105ECF c-methyltransferase DR996_09400 ENOG41076E6 Uroporphyrinogen-III Synthase DR996_09405 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DR996_09410 ENOG4107T0K Adenylate cyclase DR996_09415 ENOG4105XQ6 frataxin-like protein DR996_09425 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DR996_09430 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DR996_09440 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DR996_09445 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant DR996_09450 ENOG4105BZU Histidine kinase DR996_09455 ENOG4106IUH DTW domain containing protein DR996_09470 ENOG4105DQF Hydrolase DR996_09475 ENOG4108EUD Lysophospholipase DR996_09480 ENOG410829K Lysine exporter protein (Lyse ygga) DR996_09490 ENOG4108NYK Tape measure protein DR996_09505 ENOG4105EFV Major head subunit DR996_09580 ENOG41082YX Transcriptional regulator, arsr family DR996_09585 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DR996_09640 ENOG41076UM multiple antibiotic resistance (MarC)-related protein DR996_09650 ENOG4106H78 methyltransferase DR996_09660 ENOG4105CAK Cell division ATP-binding protein ftsE DR996_09665 ENOG4105CRP Part of the ABC transporter FtsEX involved in DR996_09670 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DR996_09675 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DR996_09680 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) DR996_09685 ENOG4105X6C Flagellar basal body-associated protein FliL DR996_09690 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) DR996_09695 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) DR996_09700 ENOG4105E55 glycerol-3-phosphate acyltransferase DR996_09710 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DR996_09720 ENOG4107R73 Mate efflux family protein DR996_09740 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) DR996_09745 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DR996_09755 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DR996_09825 ENOG4105JIM Phosphatidylserine synthase DR996_09835 ENOG4105D4A Cell wall formation (By similarity) DR996_09840 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase DR996_09845 ENOG4105CS9 pantothenic acid kinase DR996_09865 ENOG4108C33 Resolvase DR996_09885 ENOG4105C7H Helicase, RecD TraA family DR996_09905 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DR996_09915 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DR996_09925 ENOG4105PM1 preprotein translocase subunit SecE DR996_09930 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DR996_09935 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DR996_09940 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DR996_09945 ENOG4108VZM 50s ribosomal protein L10 DR996_09950 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DR996_09955 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DR996_09960 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DR996_09965 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor DR996_09970 ENOG4105E09 nadh pyrophosphatase DR996_09975 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DR996_09980 ENOG4108RG0 uracil-dna glycosylase DR996_09985 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase DR996_09990 ENOG4105R2J Conserved Protein DR996_10010 ENOG4105C12 Phosphoribosylglycinamide synthetase DR996_10015 ENOG4105DC1 bifunctional purine biosynthesis protein purh DR996_10025 ENOG4105W1Y Transcriptional regulator DR996_10030 ENOG4108M3R transcriptional activator CadC DR996_10045 ENOG4105D5Q Arginine ornithine antiporter DR996_10050 ENOG4105CXN decarboxylase DR996_10095 ENOG4105BZU Histidine kinase DR996_10100 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) DR996_10105 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DR996_10110 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DR996_10120 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DR996_10125 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DR996_10130 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DR996_10135 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DR996_10150 ENOG4105D8G Major Facilitator superfamily DR996_10155 ENOG4105BZU Histidine kinase DR996_10160 ENOG4105C9Q fumarate hydratase class II DR996_10175 ENOG4107QN1 sodium solute DR996_10185 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DR996_10195 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DR996_10200 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DR996_10205 ENOG4108IJ0 Aspartate ammonia-lyase DR996_10210 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 DR996_10215 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DR996_10225 ENOG4105E0F Histidine kinase DR996_10230 ENOG4105E3W Two component transcriptional regulator (Winged helix family DR996_10235 ENOG4108SPG Periplasmic Protein DR996_10240 ENOG41076HS cation diffusion facilitator family transporter DR996_10245 ENOG4105CTQ phosphohexokinase DR996_10255 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DR996_10260 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DR996_10275 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DR996_10280 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DR996_10295 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) DR996_10300 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) DR996_10315 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) DR996_10325 ENOG41062JF Transcriptional regulator DR996_10335 ENOG41063SB peptidase DR996_10340 ENOG4105D7W serine acetyltransferase DR996_10345 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DR996_10350 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) DR996_10355 ENOG4107YZP Rhodanese domain protein DR996_10360 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DR996_10375 ENOG4105C8P )-transporter DR996_10380 ENOG4105EKQ RNA-directed DNA polymerase DR996_10390 ENOG4105DJ4 phosphatidylserine decarboxylase DR996_10395 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DR996_10400 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) DR996_10475 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DR996_10480 ENOG4105K8N protein family UPF0079, ATPase DR996_10485 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DR996_10490 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DR996_10495 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DR996_10500 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DR996_10505 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DR996_10510 ENOG4107QJR hflk protein DR996_10515 ENOG4105EPW hflc protein DR996_10525 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DR996_10535 ENOG4108UV7 flagellar protein motX DR996_10540 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DR996_10545 ENOG4105KPV Transcriptional regulator DR996_10550 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DR996_10555 ENOG4105C2N RNA methyltransferase TrmH family group 3 DR996_10560 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DR996_10565 ENOG4105C31 Tryptophanyl-tRNA synthetase DR996_10580 ENOG4105DDQ anthranilate synthase DR996_10585 ENOG4105C8Y Acetylornithine aminotransferase DR996_10595 ENOG4105C26 Dehydrogenase DR996_10610 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) DR996_10615 ENOG4105YP7 UPF0270 protein DR996_10620 ENOG4105DNZ Alpha Beta Hydrolase DR996_10630 ENOG4105C5H ABC transporter DR996_10640 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DR996_10655 ENOG4108YZY peptidylprolyl cis-trans isomerase DR996_10665 ENOG4105D44 asparaginase DR996_10670 ENOG41069P5 Protein slyX homolog DR996_10680 ENOG4108V1T peptidylprolyl cis-trans isomerase DR996_10685 ENOG4105WWK YheO domain protein DR996_10690 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) DR996_10695 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) DR996_10700 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) DR996_10705 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DR996_10710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DR996_10715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DR996_10720 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DR996_10725 ENOG4105W53 bacterioferritin-associated ferredoxin DR996_10730 ENOG4108UQY Iron-storage protein DR996_10735 ENOG4105C6K Malic enzyme DR996_10740 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) DR996_10745 ENOG4105C28 cystathionine DR996_10750 ENOG4105CFH Aspartokinase DR996_10755 ENOG4105SYT Methylenetetrahydrofolate reductase DR996_10765 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) DR996_10770 ENOG4105CWC Acetylornithine deacetylase DR996_10775 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DR996_10780 ENOG4105CAS nag kinase DR996_10785 ENOG4105CDH Citrulline--aspartate ligase DR996_10790 ENOG4105CH7 arginosuccinase DR996_10805 ENOG4107QN2 dihydrolipoyl dehydrogenase DR996_10810 ENOG4105EHV domain protein DR996_10820 ENOG4108JQC penicillin-binding protein 1A DR996_10845 ENOG4105E4G Type IV pilus DR996_10850 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DR996_10855 ENOG4105D49 3-dehydroquinate synthase DR996_10865 ENOG4105DFE Dna adenine methylase DR996_10870 ENOG4105DJV ribulose-phosphate 3-epimerase DR996_10875 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DR996_10880 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) DR996_10885 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DR996_10890 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DR996_10900 ENOG4105CDU Replicative dna helicase DR996_10905 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DR996_10915 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DR996_10920 ENOG4107QP8 phosphohexose isomerase DR996_10930 ENOG4105MYN Zinc uptake regulation protein DR996_10935 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DR996_10955 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DR996_10960 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DR996_10965 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DR996_11030 ENOG4105EEQ Na H antiporter DR996_11035 ENOG4105C3R Methionine synthase DR996_11040 ENOG4105CFH Aspartokinase DR996_11050 ENOG4105C5R Aminotransferase DR996_11060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DR996_11065 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DR996_11070 ENOG41086KC Transcriptional regulator DR996_11075 ENOG4108UUM single-stranded DNA-binding protein DR996_11080 ENOG41062P1 Diguanylate cyclase phosphodiesterase DR996_11115 ENOG4107QHF type ii secretion system protein e DR996_11120 ENOG4105D7Q type ii secretion system DR996_11170 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DR996_11175 ENOG4105VQ7 Rod shape-determining protein MreD DR996_11180 ENOG4108Z03 MAF-like protein DR996_11185 ENOG4105C03 ribonuclease DR996_11190 ENOG4105QD6 exported protein DR996_11200 ENOG4105D1U peptidase U62 modulator of DNA gyrase DR996_11205 ENOG4108IAB Phoh family DR996_11210 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) DR996_11235 ENOG4105N42 UPF0307 protein DR996_11240 ENOG4105CMS peptidase U62, modulator of DNA gyrase DR996_11245 ENOG4105CJW magnesium transporter DR996_11250 ENOG41080Z8 PHOSPHOCARRIER protein DR996_11255 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DR996_11260 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN DR996_11265 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA DR996_11270 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DR996_11275 ENOG4108IUZ ABC transporter DR996_11280 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA DR996_11290 ENOG4105C2X Arabinose 5-phosphate isomerase DR996_11300 ENOG4105DHJ ABC, transporter DR996_11305 ENOG4105CY3 ABC transporter, permease DR996_11310 ENOG4107PE3 Mammalian cell entry related domain protein DR996_11315 ENOG4105E3I toluene tolerance DR996_11325 ENOG4105VFK BolA family DR996_11330 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DR996_11335 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase DR996_11340 ENOG4105KME endoribonuclease L-psp DR996_11345 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) DR996_11350 ENOG4105CXT aspartate transcarbamylase DR996_11360 ENOG4105DBV ornithine carbamoyltransferase DR996_11365 ENOG4105CEU Arginine dihydrolase DR996_11380 ENOG4108MJ3 acetyltransferase DR996_11390 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DR996_11395 ENOG4105MYG DNA polymerase iii, chi subunit DR996_11420 ENOG4107JEE Short-chain dehydrogenase reductase Sdr DR996_11535 ENOG4105VZJ PTS System DR996_11545 ENOG4105VCP PTS System DR996_11560 ENOG4105ETE Transcriptional regulator (LacI family DR996_11700 ENOG4105CSV Glutaminase DR996_11705 ENOG4105CSA Coproporphyrinogen iii oxidase DR996_11710 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DR996_11720 ENOG4105VZ9 UPF0235 protein DR996_11725 ENOG4108VIA integral membrane protein DR996_11730 ENOG4105II7 pyrroline-5-carboxylate reductase DR996_11735 ENOG4105DFA alanine racemase domain protein DR996_11740 ENOG4105CZX twitching motility protein DR996_11745 ENOG4105CZX twitching motility protein DR996_11750 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DR996_11755 ENOG4108UJU UPF0301 protein DR996_11760 ENOG4105D7Z glutathione synthase DR996_11765 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DR996_11770 ENOG4105RWS endonuclease I DR996_11775 ENOG4105GPY SprT protein DR996_11790 ENOG4105CV1 Transketolase (EC 2.2.1.1) DR996_11800 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DR996_11805 ENOG4105BZA Phosphoglycerate kinase DR996_11810 ENOG4105D2N Aldolase DR996_11815 ENOG4105D64 Mechanosensitive ion channel DR996_11830 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DR996_11835 ENOG4105MPN Membrane DR996_11845 ENOG4108JQ1 Dehydrogenase DR996_11850 ENOG4105E66 phosphoriboisomerase A DR996_11855 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DR996_11865 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) DR996_11880 ENOG4105D0A hydroxylase DR996_11885 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DR996_11900 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DR996_11905 ENOG4105Y75 tpr repeat protein DR996_11915 ENOG4108IYU L-aspartate oxidase DR996_11925 ENOG4105EMN RNA polymerase sigma factor DR996_11945 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DR996_11950 ENOG4105C3F Signal peptidase i DR996_11955 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DR996_11960 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DR996_11965 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) DR996_11970 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DR996_11975 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DR996_11980 ENOG4105BZU Histidine kinase DR996_11990 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DR996_11995 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DR996_12000 ENOG4105DXN mazG family DR996_12005 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DR996_12015 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DR996_12020 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DR996_12025 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DR996_12030 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) DR996_12035 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) DR996_12040 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DR996_12050 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DR996_12055 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DR996_12060 ENOG4107TH8 cina domain protein DR996_12065 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DR996_12070 ENOG4105Y3E Modulates RecA activity (By similarity) DR996_12080 ENOG4105CFH Aspartokinase DR996_12085 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DR996_12165 ENOG41086KC Transcriptional regulator DR996_12175 ENOG4107QSA Oxaloacetate decarboxylase DR996_12180 ENOG4105D9Q decarboxylase (Beta subunit) DR996_12190 ENOG4105W39 Membrane DR996_12200 ENOG4105D9M gamma-glutamylcysteine synthetase DR996_12210 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DR996_12215 ENOG4108JU6 CBS domain protein DR996_12220 ENOG4106KVJ cytochrome C assembly protein DR996_12225 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DR996_12230 ENOG4105K5M 30s ribosomal protein S16 DR996_12235 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DR996_12240 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DR996_12245 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DR996_12250 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DR996_12255 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) DR996_12260 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DR996_12265 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) DR996_12270 ENOG4105D7Q type ii secretion system DR996_12275 ENOG4107QHF type ii secretion system protein e DR996_12280 ENOG4105KHS type IV fimbrial pilin protein DR996_12285 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DR996_12295 ENOG41073TP transcriptional regulator DR996_12300 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DR996_12305 ENOG4107QSN dihydrolipoamide acetyltransferase DR996_12310 ENOG4107QN2 dihydrolipoyl dehydrogenase DR996_12320 ENOG410630P Transcriptional regulator DR996_12325 ENOG4108UGV hypoxanthine phosphoribosyltransferase DR996_12330 ENOG41077A9 carbonic anhydrase DR996_12335 ENOG4105CHH sulfate transporter DR996_12340 ENOG4105DA5 (ABC) transporter DR996_12345 ENOG4105E3A (ABC) transporter DR996_12350 ENOG4105D1S lipid A biosynthesis DR996_12355 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DR996_12360 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DR996_12365 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DR996_12370 ENOG4105DJ0 Poly(A) Polymerase DR996_12375 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DR996_12380 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DR996_12385 ENOG4105PW4 Sugar fermentation stimulation protein homolog DR996_12390 ENOG4105CQ7 ATP-dependent helicase DR996_12395 ENOG4105BZ4 penicillin-binding protein DR996_12400 ENOG4105D78 K07001 NTE family protein DR996_12405 ENOG4107QIJ Aconitate hydratase 2 DR996_12415 ENOG4105XTV UPF0231 protein DR996_12420 ENOG4108YZA Nitrogen regulatory protein pii DR996_12440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DR996_12455 ENOG4105E2D ec 3.2.1.52 DR996_12460 ENOG4105RD7 BadF BadG BcrA BcrD DR996_12470 ENOG4108JQ7 (ABC) transporter DR996_12475 ENOG4105C3U ABC transporter DR996_12480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DR996_12490 ENOG4107QRA Extracellular solute-binding protein, family 5 DR996_12505 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) DR996_12510 ENOG4105F4G Membrane DR996_12520 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DR996_12525 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DR996_12535 ENOG4105BZS acriflavin resistance protein DR996_12540 ENOG4105DR5 peptidase DR996_12545 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DR996_12560 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase DR996_12565 ENOG4107QE9 Inherit from COG: Membrane DR996_12570 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DR996_12575 ENOG4105HBR Rna-binding protein DR996_12580 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) DR996_12585 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DR996_12590 ENOG4105EEI dihydropteroate synthase DR996_12595 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DR996_12600 ENOG4105NTZ Preprotein translocase subunit SecG DR996_12615 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DR996_12620 ENOG4105CHV Transcription elongation factor NusA DR996_12625 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DR996_12630 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DR996_12635 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DR996_12640 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DR996_12645 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DR996_12660 ENOG4105C3S Mate efflux family protein DR996_12675 ENOG4105BZU Histidine kinase DR996_12685 ENOG4108YYD acetyltransferase DR996_12705 ENOG4105BZU Histidine kinase DR996_12710 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DR996_12755 ENOG4105EKQ RNA-directed DNA polymerase DR996_12800 ENOG4108R0M Aminoglycoside DR996_12835 ENOG4105KT5 UmuD protein DR996_12860 ENOG4105CVR type I restriction-modification system DR996_12995 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_13000 ENOG4105T95 Thiol disulfide interChange protein DR996_13055 ENOG4108UUM single-stranded DNA-binding protein DR996_13130 ENOG4105W1Y Transcriptional regulator DR996_13195 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DR996_13200 ENOG4105EYA deoxyribonuclease DR996_13205 ENOG4105D9N nucleoside DR996_13210 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DR996_13215 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DR996_13220 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DR996_13225 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DR996_13235 ENOG4105EAC phosphoserine phosphatase DR996_13245 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DR996_13250 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DR996_13255 ENOG4105ETT transcriptional Regulator, LysR family DR996_13290 ENOG4108IQE Amp-dependent synthetase and ligase DR996_13295 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division DR996_13370 ENOG4105CDV Ompa motb domain protein DR996_13380 ENOG41064T2 transcriptional regulator, lysR family DR996_13385 ENOG4107WCA isomerase DR996_13390 ENOG4107W6W Conserved Protein DR996_13395 ENOG4105E5D amino acid DR996_13400 ENOG4105FK9 beta-D-galactosidase beta subunit DR996_13405 ENOG4105CNT hydrolase family 2 DR996_13410 ENOG4105CQ4 Transcriptional regulator DR996_13415 ENOG4105CJN penicillin-binding protein DR996_13420 ENOG4105CMR udp-glucose 4-epimerase DR996_13425 ENOG4105F0Z galactose-1-phosphate uridylyltransferase DR996_13430 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DR996_13435 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DR996_13440 ENOG41060NJ transcriptional regulator DR996_13445 ENOG4105CI1 PTS System DR996_13455 ENOG4108Y51 tRNA-binding protein DR996_13490 ENOG4107QN2 dihydrolipoyl dehydrogenase DR996_13505 ENOG4108JU3 Alkyl hydroperoxide reductase DR996_13510 ENOG4105DFD Na H antiporter DR996_13530 ENOG4105CMT Dihydroxyacetone kinase DR996_13535 ENOG4108UTZ Dihydroxyacetone kinase DR996_13545 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DR996_13550 ENOG41060W2 glyoxylate carboligase DR996_13555 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DR996_13560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DR996_13565 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DR996_13570 ENOG4105E98 transcriptional regulator DeoR family DR996_13575 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DR996_13580 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DR996_13590 ENOG4105CXY transporter DR996_13595 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DR996_13600 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) DR996_13615 ENOG4105X2V dna damage-inducible protein DR996_13620 ENOG4105EVZ LysR family transcriptional regulator DR996_13630 ENOG4105E68 Sulfatase DR996_13635 ENOG4105DSY exodeoxyribonuclease V, gamma DR996_13640 ENOG4107QKA exodeoxyribonuclease V beta DR996_13645 ENOG4107QYX exodeoxyribonuclease v alpha DR996_13660 ENOG4107QZM n-acetylglutamate synthase DR996_13675 ENOG4105CA3 membrane-bound lytic murein transglycosylase DR996_13680 ENOG4105CUZ uba thif-type nad fad binding protein DR996_13685 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) DR996_13690 ENOG4105C9B Cysteine desulfurase DR996_13695 ENOG4107S0N DJ-1 family DR996_13700 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DR996_13725 ENOG4105K6V RNA polymerase DR996_13740 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DR996_13750 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) DR996_13755 ENOG4105M85 Bola protein DR996_13760 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DR996_13765 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DR996_13770 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DR996_13775 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DR996_13780 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DR996_13785 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) DR996_13790 ENOG4105CJ2 (LipO)protein DR996_13805 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DR996_13810 ENOG4105C9U ATP-dependent DNA helicase RecQ DR996_13815 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DR996_13830 ENOG4105C8J )-transporter DR996_13840 ENOG4105W1I UPF0253 protein DR996_13850 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DR996_13855 ENOG4108R96 Methyltransferase, YaeB family DR996_13860 ENOG4105NRA 50s ribosomal protein l31 type b DR996_13870 ENOG4105CFC Transporter DR996_13880 ENOG4108UPT UPF0178 protein DR996_13905 ENOG4105WP7 tRNA pseudouridine synthase C DR996_13910 ENOG4105DR9 pseudouridine synthase DR996_13915 ENOG4108T8E UPF0325 protein DR996_13920 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) DR996_13925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DR996_13930 ENOG4105CE9 30S ribosomal protein S2 DR996_13935 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DR996_13940 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DR996_13945 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DR996_13950 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DR996_13955 ENOG4105KNE Phosphatidate cytidylyltransferase DR996_13960 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DR996_13965 ENOG4105DZP Membrane-associated zinc metalloprotease DR996_13975 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) DR996_13980 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DR996_13985 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DR996_13990 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DR996_13995 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DR996_14000 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DR996_14005 ENOG4105C0B DNA polymerase III (alpha subunit) DR996_14010 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DR996_14015 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DR996_14020 ENOG4105N7H Cytochrome DR996_14025 ENOG4108YZA Nitrogen regulatory protein pii DR996_14030 ENOG4107NA1 Endonuclease Exonuclease phosphatase DR996_14040 ENOG4105E9H Lytic Murein transglycosylase DR996_14045 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DR996_14050 ENOG4105D1A Methyltransferase DR996_14055 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DR996_14060 ENOG4107RZZ dna polymerase iii epsilon subunit DR996_14085 ENOG4107QPN acyl-Coa dehydrogenase DR996_14090 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DR996_14095 ENOG4105E7A Glutamine amidotransferase DR996_14100 ENOG4108V3E phosphoribosylglycinamide formyltransferase DR996_14105 ENOG4105CXB phosphoribosylaminoimidazole synthetase DR996_14110 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DR996_14115 ENOG4105C2W permease DR996_14130 ENOG4105CS1 NAD(P)H quinone oxidoreductase DR996_14135 ENOG4105K89 arsenate reductase DR996_14140 ENOG4105ERG peptidase m48, ste24p DR996_14155 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DR996_14235 ENOG4105M5J Cupin 2, conserved barrel domain protein DR996_14245 ENOG4105CHR reductase DR996_14255 ENOG4105C2X Arabinose 5-phosphate isomerase DR996_14275 ENOG4105D2H Uronic isomerase DR996_14280 ENOG4105EY3 heparinase II III family protein DR996_14290 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DR996_14320 ENOG4105RH4 Glycine cleavage system transcriptional repressor DR996_14330 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DR996_14345 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DR996_14350 ENOG4105KUZ arsenate reductase DR996_14370 ENOG4105QZU Inner membrane protein YfeZ DR996_14375 ENOG4105EZR dyp-type peroxidase family protein DR996_14380 ENOG4108K2B transcriptional regulator DR996_14385 ENOG4105F8D glycoside hydrolase family 4 DR996_14390 ENOG4105CT4 transporter DR996_14400 ENOG4105I03 Flagellin DR996_14410 ENOG4105I03 Flagellin DR996_14415 ENOG4105I03 Flagellin DR996_14420 ENOG41063QE flagellar protein FlaG DR996_14425 ENOG4107BRV flagellar capping protein DR996_14435 ENOG4105MQ3 flagellar protein FliS DR996_14445 ENOG4105BZU Histidine kinase DR996_14455 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DR996_14460 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DR996_14465 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DR996_14475 ENOG4108JIR Flagellum-specific ATP synthase DR996_14500 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DR996_14505 ENOG4105DD5 Flagellar motor switch protein DR996_14510 ENOG4105VTB flagellar biosynthesis protein fliO DR996_14515 ENOG4105CN7 Flagellar biosynthetic protein FliP DR996_14520 ENOG4105VS8 Flagellar biosynthetic protein fliq DR996_14525 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DR996_14530 ENOG4105D00 flagellar biosynthetic protein flhB DR996_14535 ENOG4105D7B Flagellar biosynthesis protein flha DR996_14540 ENOG4105FZW flagellar biosynthesis regulator FlhF DR996_14550 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DR996_14555 ENOG4108VYJ response regulator receiver protein DR996_14560 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) DR996_14570 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DR996_14575 ENOG4107QJE Chromosome Partitioning Protein DR996_14585 ENOG4108V3W Chemotaxis protein, CheW DR996_14595 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) DR996_14600 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) DR996_14605 ENOG41060IM Heme exporter protein DR996_14615 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) DR996_14620 ENOG4105DA4 cytochrome c-type biogenesis protein DR996_14625 ENOG4107QX9 Thiol disulfide interChange protein DR996_14630 ENOG4108M1T Cytochrome c-type biogenesis protein DR996_14635 ENOG4105KWW Biogenesis protein DR996_14640 ENOG410903C (LipO)protein DR996_14645 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation DR996_14650 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation DR996_14670 ENOG4105CHU acetyl-coa acetyltransferase DR996_14675 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DR996_14685 ENOG4107QXK peptidase DR996_14690 ENOG4108BY2 phosphohistidine phosphatase DR996_14695 ENOG4108DG9 Smr protein MutS2 DR996_14700 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) DR996_14705 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DR996_14710 ENOG4105EN6 Membrane DR996_14715 ENOG4108BPE -transporting atpase DR996_14720 ENOG4105MH2 YfcL protein DR996_14735 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) DR996_14740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DR996_14750 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) DR996_14755 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DR996_14765 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DR996_14775 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DR996_14780 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DR996_14785 ENOG4108S3P Sporulation domain protein DR996_14790 ENOG4105E96 Colicin v production protein DR996_14795 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DR996_14800 ENOG4105EJC lysr family transcriptional regulator DR996_14805 ENOG4105I93 response regulator DR996_14815 ENOG4105WD1 Membrane DR996_14820 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DR996_14825 ENOG4107QMP dna polymerase iii subunits gamma and tau DR996_14830 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DR996_14835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DR996_14855 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DR996_14860 ENOG4105C44 Serine transporter DR996_14870 ENOG4105CEM UPF0597 protein DR996_14875 ENOG4105WWK YheO domain protein DR996_14880 ENOG4105KRS Proteinase inhibitor DR996_14890 ENOG4108ZZ3 UPF0260 protein DR996_14895 ENOG4105Y3U Transglycosylase-associated protein DR996_14900 ENOG4105D0C transport protein DR996_14905 ENOG4105CVK Glutamate decarboxylase DR996_14920 ENOG4108UYE Lactoylglutathione lyase DR996_14930 ENOG4105G6Z alkaline phosphatase DR996_14945 ENOG4105DHI Methyltransferase DR996_14950 ENOG4107SDU Methyl-accepting chemotaxis DR996_14965 ENOG4105DSB aldose 1-epimerase DR996_14970 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DR996_14975 ENOG4105E0X reductase DR996_14985 ENOG4105VUT cytoplasmic protein DR996_14990 ENOG4105HDK L-asparaginase DR996_14995 ENOG4105D07 Signal peptide peptidase, SppA DR996_15000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DR996_15005 ENOG41069NU Nitroreductase DR996_15010 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DR996_15020 ENOG4108RU0 short-chain dehydrogenase reductase DR996_15025 ENOG4105DGU Histone deacetylase DR996_15030 ENOG4108M3P Membrane DR996_15045 ENOG4105E68 Sulfatase DR996_15050 ENOG4105YDX UPF0352 protein DR996_15055 ENOG4106V8H Nucleoid-associated protein DR996_15070 ENOG4105DFD Na H antiporter DR996_15075 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DR996_15085 ENOG4105EYW Ion transport protein DR996_15090 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DR996_15095 ENOG4105C0A alcohol dehydrogenase DR996_15110 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DR996_15115 ENOG4105M2J Glutaredoxin DR996_15125 ENOG4105D3Y Na H antiporter DR996_15130 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) DR996_15135 ENOG4105EIY sodium-type flagellar protein motY DR996_15140 ENOG4106WH9 Protein of unknown function (DUF2753) DR996_15145 ENOG4108UYE Lactoylglutathione lyase DR996_15150 ENOG4105CSM endonuclease III DR996_15155 ENOG4105DZB Electron transport complex DR996_15160 ENOG4108UQQ Electron transport complex DR996_15165 ENOG4105D6A Electron transport complex DR996_15175 ENOG4108R3D Electron transport complex DR996_15180 ENOG4105DGN Electron transport complex DR996_15185 ENOG4105C6N Formate acetyltransferase DR996_15195 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DR996_15200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_15210 ENOG4105CHW UPF0052 protein DR996_15215 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DR996_15220 ENOG4108RIR Molybdenum cofactor biosynthesis protein DR996_15225 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DR996_15230 ENOG4105M00 molybdopterin converting factor, subunit 1 DR996_15235 ENOG4108ZAF Molybdopterin DR996_15240 ENOG4107QSI ABC, transporter DR996_15245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DR996_15250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DR996_15255 ENOG4105C3U ABC transporter DR996_15260 ENOG4108JQ7 (ABC) transporter DR996_15265 ENOG4105CHF Glutathione S-transferase DR996_15270 ENOG4107PU6 Membrane DR996_15280 ENOG4108DNC Involved in acetate metabolism (By similarity) DR996_15285 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DR996_15290 ENOG4105PQ6 UPF0208 membrane protein DR996_15305 ENOG4105C7J ABC transporter, permease DR996_15310 ENOG4108JJB ABC transporter DR996_15315 ENOG4107R28 alpha amylase, catalytic region DR996_15320 ENOG4105BZU Histidine kinase DR996_15325 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) DR996_15330 ENOG4106RHG Yeca family DR996_15335 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) DR996_15340 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DR996_15345 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) DR996_15370 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DR996_15375 ENOG4105D1F ATP-binding protein DR996_15380 ENOG4105DBI uridine monophosphokinase DR996_15390 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase DR996_15400 ENOG4105CHH sulfate transporter DR996_15410 ENOG4105C03 ribonuclease DR996_15415 ENOG4105EI2 Pseudouridine synthase DR996_15420 ENOG4108UHJ MAF-like protein DR996_15425 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein DR996_15430 ENOG4105VGS 50s ribosomal protein l32 DR996_15435 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DR996_15440 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DR996_15445 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DR996_15450 ENOG4105CHR reductase DR996_15455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DR996_15460 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DR996_15470 ENOG4105HHA aminodeoxychorismate lyase DR996_15475 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DR996_15480 ENOG4107QRG dna polymerase iii DR996_15485 ENOG4105F8V Hydrolase, tatD family DR996_15490 ENOG4105CI1 PTS System DR996_15505 ENOG4105C8J )-transporter DR996_15520 ENOG4108NRW Phospholipase, patatin family DR996_15525 ENOG4105CA9 Pyruvate kinase DR996_15530 ENOG4105DAG ROK family DR996_15540 ENOG4105C0B DNA polymerase III (alpha subunit) DR996_15555 ENOG4105UBK short-chain dehydrogenase reductase DR996_15560 ENOG4105ERU peptidase DR996_15570 ENOG4105CAT Cytidine monophosphate kinase DR996_15575 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DR996_15580 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DR996_15585 ENOG4105Q4A inner membrane protein yciS DR996_15590 ENOG4105CFV Tetratricopeptide repeat protein DR996_15595 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DR996_15600 ENOG4108J59 Extracellular solute-binding protein, family 5 DR996_15660 ENOG4105ENH Sulfatase DR996_15665 ENOG4108WUH Transcriptional regulator, TetR family DR996_15670 ENOG4108Q2G (LipO)protein DR996_15675 ENOG4105DY2 Paraquat-inducible protein b DR996_15680 ENOG4105F1S paraquat-inducible protein a DR996_15690 ENOG4105NQN cytochrome C DR996_15695 ENOG41090Y2 cytochrome C DR996_15700 ENOG4105DB1 molybdopterin oxidoreductase DR996_15705 ENOG4106WHD Tetrathionate reductase DR996_15710 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein DR996_15715 ENOG4106AFQ Histidine kinase DR996_15720 ENOG4108ZXC Two component transcriptional regulator, luxr family DR996_15735 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) DR996_15750 ENOG4105CT4 transporter DR996_15755 ENOG4105DHT Metal Dependent Phosphohydrolase DR996_15760 ENOG4105JQN Transcriptional regulator DR996_15770 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DR996_15775 ENOG4105N6Y Thioredoxin DR996_15795 ENOG41080VW acetyltransferase DR996_15835 ENOG4105DJY efflux transporter, rnd family, mfp subunit DR996_15845 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DR996_15850 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DR996_15855 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DR996_15860 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DR996_15875 ENOG41090KR LysR family transcriptional Regulator DR996_15900 ENOG4105J12 Multidrug resistance protein mdtN DR996_15905 ENOG4105EQ2 LysR family Transcriptional regulator DR996_15945 ENOG41062D9 Histidine kinase DR996_15950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DR996_15960 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) DR996_15970 ENOG4105C8Q Methyl-accepting chemotaxis DR996_15975 ENOG4105WWK YheO domain protein DR996_15980 ENOG4105KME endoribonuclease L-psp DR996_15985 ENOG4107R6U sodium dicarboxylate symporter DR996_15990 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DR996_16020 ENOG4105CCT upf0313 protein DR996_16040 ENOG4105DZ2 Transcriptional regulator DR996_16045 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DR996_16055 ENOG4105K9H YciI-like protein DR996_16060 ENOG4105NAU thioesterase Superfamily protein DR996_16065 ENOG4107835 probably involved in intracellular septation (By similarity) DR996_16075 ENOG4105BZU Histidine kinase DR996_16085 ENOG4105CK2 sodium dicarboxylate symporter DR996_16090 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DR996_16095 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DR996_16100 ENOG4105DK0 Indole-3-glycerol phosphate synthase DR996_16105 ENOG4108I0Q anthranilate phosphoribosyltransferase DR996_16110 ENOG4105DDQ anthranilate synthase DR996_16115 ENOG4105CRQ synthase (Component I) DR996_16125 ENOG4105DB7 PHP domain protein DR996_16130 ENOG4107RTD sua5 ycio yrdc ywlc family protein DR996_16140 ENOG4105FE9 pseudouridine synthase DR996_16145 ENOG4108W5H UPF0263 protein DR996_16160 ENOG4105CQ2 DNA polymerase DR996_16165 ENOG4105WH1 Two component transcriptional regulator luxr family DR996_16170 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DR996_16210 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) DR996_16235 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DR996_16240 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DR996_16250 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DR996_16255 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DR996_16270 ENOG4105EAU Plays a role in nitrite reduction (By similarity) DR996_16280 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein DR996_16285 ENOG4105DVI reductase, NrfD DR996_16290 ENOG4105DA4 cytochrome c-type biogenesis protein DR996_16295 ENOG4107QX9 Thiol disulfide interChange protein DR996_16300 ENOG4108DMF Cytochrome C biogenesis protein DR996_16310 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DR996_16335 ENOG4105DIT ErfK YbiS YcfS YnhG family protein DR996_16340 ENOG4105EAQ (twin-arginine translocation) pathway signal DR996_16345 ENOG4105C5X domain protein DR996_16360 ENOG4105CH5 extracellular solute-binding protein, family 7 DR996_16370 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DR996_16385 ENOG41067TZ transcriptional regulator, MarR family DR996_16390 ENOG4105C94 Transporter DR996_16395 ENOG4105C8Q Methyl-accepting chemotaxis DR996_16415 ENOG4105CGF Aromatic amino acid aminotransferase DR996_16420 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DR996_16425 ENOG4107RUZ Sss sodium solute transporter superfamily DR996_16435 ENOG4105ETE Transcriptional regulator (LacI family DR996_16450 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DR996_16465 ENOG4105C5S asparaginyl-tRNA synthetase DR996_16470 ENOG4105C8Q Methyl-accepting chemotaxis DR996_16475 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DR996_16480 ENOG4105WH1 Two component transcriptional regulator luxr family DR996_16490 ENOG4105BZU Histidine kinase DR996_16495 ENOG4105EJQ L-serine dehydratase DR996_16500 ENOG4105C44 Serine transporter DR996_16515 ENOG4105BZU Histidine kinase DR996_16520 ENOG4105CRQ synthase (Component I) DR996_16535 ENOG4105CM6 amino acid regulated cytosolic protein DR996_16540 ENOG4106K28 UPF0283 membrane protein DR996_16550 ENOG4105D9U N-acetyltransferase DR996_16720 ENOG4105D9P serine threonine protein kinase DR996_16820 ENOG4108KU3 Integrase DR996_17005 ENOG4108W2Y isochorismatase DR996_17035 ENOG4108MTT Glutamate-rich protein grpB DR996_17115 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DR996_17225 ENOG4105EWC Purine nucleoside phosphorylase DR996_17365 ENOG4105KVH Transcriptional regulator DR996_17375 ENOG4105EC3 peptidase S51, dipeptidase E DR996_17395 ENOG4107RJ1 sodium solute DR996_17410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DR996_17420 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DR996_17425 ENOG4105ETE Transcriptional regulator (LacI family DR996_17430 ENOG4105CNV Aldolase DR996_17440 ENOG4105CHR reductase DR996_17450 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DR996_17465 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DR996_17470 ENOG4105C8P )-transporter DR996_17475 ENOG4105BZU Histidine kinase DR996_17480 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_17485 ENOG4105BZU Histidine kinase DR996_17490 ENOG4105CPI Metal Dependent Phosphohydrolase DR996_17495 ENOG410829K Lysine exporter protein (Lyse ygga) DR996_17500 ENOG4105G0K glycine radical enzyme YjjI family DR996_17505 ENOG41076CZ activating enzyme DR996_17515 ENOG4105EE5 Membrane protein terC DR996_17525 ENOG4105DHT Metal Dependent Phosphohydrolase DR996_17535 ENOG4105BZU Histidine kinase DR996_17550 ENOG4105E0U tyrosine-specific transport protein DR996_17570 ENOG4105BZ1 (ABC) transporter DR996_17575 ENOG4105BZ1 (ABC) transporter DR996_17590 ENOG4105CR8 Transcriptional regulator DR996_17600 ENOG4105CK5 oxidoreductase DR996_17620 ENOG4105CFG Acts as a chaperone (By similarity) DR996_17625 ENOG4105CFG Acts as a chaperone (By similarity) DR996_17635 ENOG4105BZU Histidine kinase DR996_17660 ENOG4105D4Y metalloprotease DR996_17680 ENOG4108IJ9 (ABC) transporter DR996_17685 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 DR996_17705 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DR996_17720 ENOG4107QY8 reductase DR996_17725 ENOG4105QAX Iron-sulfur DR996_17730 ENOG4107KGK dmso reductase anchor subunit DR996_17735 ENOG4108NEM leader-binding protein dmsD DR996_17745 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DR996_17750 ENOG4105CQ7 ATP-dependent helicase DR996_17775 ENOG41090FY type IV pilus biogenesis stability protein PilW DR996_17780 ENOG4105CVG Homoserine O-transsuccinylase DR996_17815 ENOG4105E5D amino acid DR996_17820 ENOG4105N14 lysine exporter protein LysE YggA DR996_17825 ENOG4105CR8 Transcriptional regulator DR996_17830 ENOG4107S9F NmrA family DR996_17835 ENOG4105EJC lysr family transcriptional regulator DR996_17840 ENOG4105D1S lipid A biosynthesis DR996_17845 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DR996_17855 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DR996_17870 ENOG4105CTD carboxy-peptidase DR996_17875 ENOG410829K Lysine exporter protein (Lyse ygga) DR996_17885 ENOG4107QMS site-determining protein DR996_17905 ENOG4105BZG amino acid carrier protein DR996_17925 ENOG41063TF transcriptional regulator (AraC DR996_17960 ENOG4105CR8 Transcriptional regulator DR996_17965 ENOG4105E0M Sulfatase DR996_17970 ENOG4105C8N cysteinyl-tRNA synthetase DR996_17975 ENOG4107QI1 Mate efflux family protein DR996_17980 ENOG41080XQ Signal transduction protein with cbs domains DR996_17990 ENOG4105C94 Transporter DR996_17995 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase DR996_18000 ENOG4108JPW Aminotransferase DR996_18005 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) DR996_18010 ENOG4105CZK Aspartate kinase DR996_18020 ENOG4105CV8 reductase DR996_18025 ENOG4105HEI LysR family (Transcriptional regulator DR996_18030 ENOG4105CA0 peroxidase DR996_18050 ENOG4107RDB Major Facilitator DR996_18055 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin DR996_18060 ENOG4105HEI LysR family (Transcriptional regulator DR996_18065 ENOG4105ECR NmrA family DR996_18080 ENOG4105E7U AraC family transcriptional regulator DR996_18085 ENOG4108RNG Permease of the drug metabolite transporter DR996_18090 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) DR996_18095 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) DR996_18110 ENOG4105CMR udp-glucose 4-epimerase DR996_18115 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DR996_18130 ENOG4107V40 secretion protein, HlyD family DR996_18145 ENOG4105C87 Aminotransferase class I and II DR996_18150 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DR996_18155 ENOG4108V9W transcriptional regulatory protein DR996_18160 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DR996_18165 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) DR996_18170 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DR996_18200 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DR996_18205 ENOG4105C26 Dehydrogenase DR996_18210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DR996_18220 ENOG4105BZS acriflavin resistance protein DR996_18225 ENOG4105H1G trap transporter solute receptor taxi family DR996_18230 ENOG4105C8Q Methyl-accepting chemotaxis DR996_18235 ENOG4105EJ9 Membrane DR996_18260 ENOG4105KD7 acetyltransferase DR996_18270 ENOG4108ESY Metal dependent phosphohydrolase DR996_18275 ENOG4108ESY Metal dependent phosphohydrolase DR996_18315 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DR996_18360 ENOG4105CNA YD repeat protein DR996_18370 ENOG4105CS6 Rhs element vgr protein DR996_18385 ENOG4105CR4 methylisocitrate lyase DR996_18390 ENOG4105BZN citrate synthase DR996_18395 ENOG4108I0Z Aconitate hydratase DR996_18400 ENOG4105C7F AcnD-accessory protein PrpF DR996_18405 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DR996_18415 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap DR996_18425 ENOG410667J hydrolase DR996_18430 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DR996_18435 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DR996_18440 ENOG4105BZU Histidine kinase DR996_18450 ENOG4105CDV Ompa motb domain protein DR996_18480 ENOG4105DR4 Methyltransferase DR996_18485 ENOG4108NVR Methyl-accepting chemotaxis DR996_18490 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 DR996_18495 ENOG4108Z0T Part of a sulfur-relay system (By similarity) DR996_18505 ENOG4108MN8 Membrane DR996_18510 ENOG4105CDA abc transporter atp-binding protein DR996_18515 ENOG4105DRP amino acid AbC transporter DR996_18520 ENOG4105EZ7 amino acid ABC transporter DR996_18525 ENOG4107QXX ABC transporter DR996_18540 ENOG4108VPT UPF0234 protein DR996_18545 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DR996_18565 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DR996_18570 ENOG4105DY2 Paraquat-inducible protein b DR996_18575 ENOG4105H2K paraquat-inducible protein a DR996_18580 ENOG4105BZ1 (ABC) transporter DR996_18585 ENOG4108ZGC gaf domain protein DR996_18590 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) DR996_18595 ENOG4105CN1 protease DR996_18605 ENOG4105CD8 aminopeptidase N DR996_18615 ENOG4105C7I Dehydrogenase DR996_18620 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) DR996_18625 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) DR996_18630 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DR996_18640 ENOG4105C5H ABC transporter DR996_18655 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) DR996_18660 ENOG4105DAN ATP-dependent protease DR996_18665 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) DR996_18690 ENOG4105BZU Histidine kinase DR996_18705 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i DR996_18720 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) DR996_18730 ENOG4105C59 p-type ATPase DR996_18745 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DR996_18750 ENOG4105Q9Y Universal stress protein DR996_18755 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) DR996_18775 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DR996_18785 ENOG4105D38 putrescine abc transporter DR996_18790 ENOG4108HM4 ABC transporter DR996_18795 ENOG4107RUE extracellular solute-binding protein family 1 DR996_18800 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DR996_18815 ENOG4105QAX Iron-sulfur DR996_18820 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DR996_18830 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) DR996_18850 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DR996_18855 ENOG4105C5H ABC transporter DR996_18875 ENOG4105BZU Histidine kinase DR996_18880 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_18890 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component DR996_18895 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DR996_18900 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DR996_18905 ENOG4105CVM Molybdenum cofactor synthesis domain protein DR996_18920 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) DR996_18925 ENOG4106IUH DTW domain containing protein DR996_18980 ENOG4107TT5 NLP P60 protein DR996_18990 ENOG4105BZU Histidine kinase DR996_18995 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DR996_19010 ENOG4108R6K riboflavin synthase, subunit alpha DR996_19015 ENOG4107QI1 Mate efflux family protein DR996_19030 ENOG41082AN stage II sporulation protein DR996_19035 ENOG4107QKZ Ompa motb domain protein DR996_19040 ENOG4107V1M polysaccharide export protein DR996_19055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_19065 ENOG4107TAE Glycosyl transferase (Group 1 DR996_19105 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DR996_19305 ENOG4108IQE Amp-dependent synthetase and ligase DR996_19340 ENOG4105ETT transcriptional Regulator, LysR family DR996_19345 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DR996_19350 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DR996_19360 ENOG4105EAC phosphoserine phosphatase DR996_19370 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DR996_19375 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DR996_19380 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DR996_19385 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DR996_19390 ENOG4105D9N nucleoside DR996_19395 ENOG4105EYA deoxyribonuclease DR996_19400 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DR996_19500 ENOG4108YGG dna repair protein DR996_19525 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DR996_19540 ENOG4108UUM single-stranded DNA-binding protein DR996_19735 ENOG4105CVR type I restriction-modification system DR996_19760 ENOG4105KT5 UmuD protein DR996_19795 ENOG4108R0M Aminoglycoside DR996_19840 ENOG4105EKQ RNA-directed DNA polymerase DR996_19895 ENOG4108YYD acetyltransferase DR996_19905 ENOG4105BZU Histidine kinase DR996_19920 ENOG4105C3S Mate efflux family protein DR996_19935 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DR996_19940 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DR996_19945 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DR996_19950 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DR996_19955 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DR996_19960 ENOG4105CHV Transcription elongation factor NusA DR996_19965 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DR996_19980 ENOG4105NTZ Preprotein translocase subunit SecG DR996_19985 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DR996_19990 ENOG4105EEI dihydropteroate synthase DR996_20000 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) DR996_20005 ENOG4105HBR Rna-binding protein DR996_20010 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DR996_20015 ENOG4107QE9 Inherit from COG: Membrane DR996_20020 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase DR996_20055 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DR996_20060 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DR996_20070 ENOG4105F4G Membrane DR996_20075 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) DR996_20090 ENOG4107QRA Extracellular solute-binding protein, family 5 DR996_20100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DR996_20105 ENOG4105C3U ABC transporter DR996_20110 ENOG4108JQ7 (ABC) transporter DR996_20120 ENOG4105RD7 BadF BadG BcrA BcrD DR996_20125 ENOG4105E2D ec 3.2.1.52 DR996_20140 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DR996_20160 ENOG4108YZA Nitrogen regulatory protein pii DR996_20165 ENOG4105XTV UPF0231 protein DR996_20175 ENOG4107QIJ Aconitate hydratase 2 DR996_20180 ENOG4105D78 K07001 NTE family protein DR996_20185 ENOG4105BZ4 penicillin-binding protein DR996_20190 ENOG4105CQ7 ATP-dependent helicase DR996_20195 ENOG4105PW4 Sugar fermentation stimulation protein homolog DR996_20200 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DR996_20205 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DR996_20210 ENOG4105DJ0 Poly(A) Polymerase DR996_20215 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DR996_20220 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DR996_20225 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DR996_20230 ENOG4105D1S lipid A biosynthesis DR996_20235 ENOG4105E3A (ABC) transporter DR996_20240 ENOG4105DA5 (ABC) transporter DR996_20245 ENOG4105CHH sulfate transporter DR996_20250 ENOG41077A9 carbonic anhydrase DR996_20255 ENOG4108UGV hypoxanthine phosphoribosyltransferase DR996_20260 ENOG410630P Transcriptional regulator DR996_20270 ENOG4107QN2 dihydrolipoyl dehydrogenase DR996_20275 ENOG4107QSN dihydrolipoamide acetyltransferase DR996_20280 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DR996_20285 ENOG41073TP transcriptional regulator DR996_20295 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DR996_20300 ENOG4105KHS type IV fimbrial pilin protein DR996_20305 ENOG4107QHF type ii secretion system protein e DR996_20310 ENOG4105D7Q type ii secretion system DR996_20315 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) DR996_20320 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DR996_20325 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) DR996_20330 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DR996_20335 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DR996_20340 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DR996_20345 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DR996_20350 ENOG4105K5M 30s ribosomal protein S16 DR996_20355 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DR996_20360 ENOG4106KVJ cytochrome C assembly protein DR996_20365 ENOG4108JU6 CBS domain protein DR996_20370 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DR996_20390 ENOG4105W39 Membrane DR996_20415 ENOG41086KC Transcriptional regulator DR996_20495 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DR996_20500 ENOG4105CFH Aspartokinase DR996_20510 ENOG4105Y3E Modulates RecA activity (By similarity) DR996_20515 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DR996_20520 ENOG4107TH8 cina domain protein DR996_20525 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DR996_20530 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DR996_20540 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DR996_20545 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) DR996_20550 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) DR996_20555 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DR996_20560 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DR996_20565 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DR996_20575 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DR996_20580 ENOG4105DXN mazG family DR996_20585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DR996_20590 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DR996_20600 ENOG4105BZU Histidine kinase DR996_20605 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DR996_20610 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DR996_20615 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) DR996_20620 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DR996_20625 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DR996_20630 ENOG4105C3F Signal peptidase i DR996_20635 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DR996_20655 ENOG4105EMN RNA polymerase sigma factor DR996_20665 ENOG4108IYU L-aspartate oxidase DR996_20675 ENOG4105Y75 tpr repeat protein DR996_20680 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DR996_20695 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DR996_20700 ENOG4105D0A hydroxylase DR996_20715 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) DR996_20725 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DR996_20730 ENOG4105E66 phosphoriboisomerase A DR996_20735 ENOG4108JQ1 Dehydrogenase DR996_20745 ENOG4105MPN Membrane DR996_20750 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DR996_20765 ENOG4105D64 Mechanosensitive ion channel DR996_20770 ENOG4105D2N Aldolase DR996_20775 ENOG4105BZA Phosphoglycerate kinase DR996_20780 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DR996_20790 ENOG4105CV1 Transketolase (EC 2.2.1.1) DR996_20805 ENOG4105GPY SprT protein DR996_20810 ENOG4105RWS endonuclease I DR996_20815 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DR996_20820 ENOG4105D7Z glutathione synthase DR996_20825 ENOG4108UJU UPF0301 protein DR996_20830 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DR996_20835 ENOG4105CZX twitching motility protein DR996_20840 ENOG4105CZX twitching motility protein DR996_20845 ENOG4105DFA alanine racemase domain protein DR996_20850 ENOG4105II7 pyrroline-5-carboxylate reductase DR996_20855 ENOG4108VIA integral membrane protein DR996_20860 ENOG4105VZ9 UPF0235 protein DR996_20870 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DR996_20890 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DR996_20895 ENOG4105CEN a g-specific adenine glycosylase DR996_20965 ENOG4105C26 Dehydrogenase DR996_21015 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DR996_21020 ENOG4105ETE Transcriptional regulator (LacI family DR996_21025 ENOG410901P UPF0249 protein DR996_21035 ENOG4105VCP PTS System DR996_21105 ENOG4108KZE transcriptional regulator DR996_21125 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DR996_21150 ENOG4107JEE Short-chain dehydrogenase reductase Sdr DR996_21160 ENOG4108K5H permease YjgP YjgQ family protein DR996_21165 ENOG4108M8S permease YjgP YjgQ family protein DR996_21170 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DR996_21175 ENOG4105MYG DNA polymerase iii, chi subunit DR996_21180 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DR996_21225 ENOG4105CXT aspartate transcarbamylase DR996_21230 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) DR996_21245 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DR996_21250 ENOG4105VFK BolA family DR996_21295 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA DR996_21310 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA DR996_21325 ENOG41080Z8 PHOSPHOCARRIER protein DR996_21340 ENOG4105N42 UPF0307 protein DR996_21345 ENOG4105C5I Dehydrogenase DR996_21350 ENOG4105D3G Pseudouridine synthase DR996_21355 ENOG4105K3M )-transporter DR996_21360 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) DR996_21365 ENOG4108IAB Phoh family DR996_21370 ENOG4105D1U peptidase U62 modulator of DNA gyrase DR996_21380 ENOG4105QD6 exported protein DR996_21385 ENOG4105C03 ribonuclease DR996_21400 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DR996_21420 ENOG4105KAF membrAne DR996_21430 ENOG4108KHX Diguanylate cyclase DR996_21440 ENOG4108HCJ Hydrolase DR996_21455 ENOG4105D3G Pseudouridine synthase DR996_21460 ENOG4105UQX Mate efflux family protein DR996_21465 ENOG4105ETE Transcriptional regulator (LacI family DR996_21470 ENOG4108IJ9 (ABC) transporter DR996_21480 ENOG4105DRS transport system, permease DR996_21495 ENOG41060NJ transcriptional regulator DR996_21500 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) DR996_21505 ENOG4108K0B C-di-gmp phosphodiesterase DR996_21515 ENOG4105NBK UPF0345 protein DR996_21545 ENOG4105DN9 Na H antiporter DR996_21565 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DR996_21570 ENOG4105D03 DNA-3-methyladenine glycosylase II DR996_21580 ENOG4108VGI doxx family DR996_21585 ENOG4105C2I pirin domain protein DR996_21605 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DR996_21625 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase DR996_21635 ENOG4108K4B hydrolase DR996_21685 ENOG4105NXH GreA GreB family elongation factor DR996_21690 ENOG4105KME endoribonuclease L-psp DR996_21715 ENOG4105EHG Permease protein DR996_21725 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) DR996_21730 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions DR996_21740 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) DR996_21745 ENOG4105IY8 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DR996_21750 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) DR996_21755 ENOG4105CQM Urea amidohydrolase subunit alpha DR996_21760 ENOG4105KI2 Urea amidohydrolase subunit beta DR996_21765 ENOG4108YZ9 Urea amidohydrolase subunit gamma DR996_21770 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DR996_21785 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) DR996_21790 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions DR996_21810 ENOG4105D6U Sodium Glutamate Symporter DR996_21815 ENOG4107U9B transcriptional regulator DR996_21820 ENOG4105CZV ABC transporter DR996_21835 ENOG4105D6U Sodium Glutamate Symporter DR996_21855 ENOG4105C8Q Methyl-accepting chemotaxis DR996_21860 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DR996_21870 ENOG4108VAC response regulator DR996_21890 ENOG4105C7H Helicase, RecD TraA family DR996_21895 ENOG4105EKQ RNA-directed DNA polymerase DR996_21910 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) DR996_21925 ENOG4105EQ2 LysR family Transcriptional regulator DR996_21935 ENOG4105FCK Membrane DR996_21940 ENOG4105C5Y PTS System DR996_21945 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DR996_21950 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) DR996_21960 ENOG4108J59 Extracellular solute-binding protein, family 5 DR996_22000 ENOG4105EYF MMPL domain protein DR996_22005 ENOG4105VJY transcriptional regulator DR996_22010 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) DR996_22025 ENOG4105C26 Dehydrogenase DR996_22035 ENOG4105CK7 Sodium proline symporter DR996_22060 ENOG4105CVJ phosphoglycerate mutase DR996_22075 ENOG4105EW9 transcriptional regulator AsnC family DR996_22095 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DR996_22105 ENOG4105BZ1 (ABC) transporter DR996_22130 ENOG4105P66 Membrane DR996_22135 ENOG4108UHU Aldolase DR996_22140 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DR996_22170 ENOG4108UHU Aldolase DR996_22175 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DR996_22185 ENOG4105DEI Mannitol dehydrogenase DR996_22190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DR996_22195 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter DR996_22200 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DR996_22205 ENOG4105C6F GntR Family Transcriptional Regulator DR996_22210 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DR996_22215 ENOG4105C87 Aminotransferase class I and II DR996_22225 ENOG410904A RNA polymerase DR996_22230 ENOG4105EXG Transcriptional regulator DR996_22245 ENOG4105C1J atp-dependent rna helicase DR996_22250 ENOG4105C87 Aminotransferase class I and II DR996_22255 ENOG4105DFD Na H antiporter DR996_22260 ENOG41060NJ transcriptional regulator DR996_22265 ENOG4108RPX mosc domain containing protein DR996_22285 ENOG4108XM1 transcriptional regulator AsnC family DR996_22295 ENOG4105F4I Transcriptional regulator DR996_22305 ENOG4108N3W hemolysin secretion protein DR996_22310 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase DR996_22330 ENOG4105MVE transcriptional regulator DR996_22335 ENOG4105ZXK Dehydrogenase DR996_22340 ENOG4105G63 Type III effector Hrp-dependent DR996_22345 ENOG4105FB2 class II Aldolase DR996_22350 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DR996_22355 ENOG4105C6Z Gluconate DR996_22385 ENOG4108JU3 Alkyl hydroperoxide reductase DR996_22390 ENOG4105D3R alkyl hydroperoxide reductase DR996_22395 ENOG4105K56 Transcriptional regulator DR996_22400 ENOG4108ZHJ Organic hydroperoxide resistance protein DR996_22450 ENOG4105C19 ABC transporter DR996_22460 ENOG410642W LysR family Transcriptional regulator DR996_22470 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DR996_22480 ENOG4105CPC Aldo Keto reductase DR996_22495 ENOG4105CFP Peptidase U32 DR996_22510 ENOG4105C8Q Methyl-accepting chemotaxis DR996_22515 ENOG4107RAN Peptidase, M16 DR996_22550 ENOG4108FZ9 Chaperone DR996_22565 ENOG4105DZR Type I site-specific deoxyribonuclease DR996_22580 ENOG41082EK Restriction modification system DNA (Specificity DR996_22585 ENOG4105CVR type I restriction-modification system DR996_22740 ENOG4107QUY Guanine deaminase DR996_22755 ENOG4107SID ATP-dependent exodnase (exonuclease v) DR996_22760 ENOG4105C7H Helicase, RecD TraA family DR996_22785 ENOG4105D2S major facilitator superfamily DR996_22795 ENOG4105EJQ L-serine dehydratase DR996_22800 ENOG4105C5Y PTS System DR996_22815 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DR996_22825 ENOG4105D5B Sulfite reductase, subunit A DR996_22840 ENOG4105BZU Histidine kinase DR996_22850 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) DR996_22875 ENOG4108K8S endonuclease I DR996_22895 ENOG4105CXN decarboxylase DR996_22900 ENOG4105D5Q Arginine ornithine antiporter DR996_22910 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) DR996_22925 ENOG4107QP7 CoA-transferase subunit A DR996_22930 ENOG4105CHU acetyl-coa acetyltransferase DR996_22950 ENOG4107QNK )-transporter DR996_22960 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DR996_22965 ENOG4105CIB oxidoreductase Domain protein DR996_22970 ENOG4105EDK PfkB domain protein DR996_23000 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) DR996_23005 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DR996_23040 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) DR996_23045 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) DR996_23050 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DR996_23055 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase DR996_23060 ENOG4107T9C Alpha amylase catalytic region DR996_23075 ENOG41074DU domain protein DR996_23080 ENOG4108P2H Inner membrane protein YjiG DR996_23085 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DR996_23095 ENOG4105CK2 sodium dicarboxylate symporter DR996_23125 ENOG4105F27 Major Facilitator DR996_23130 ENOG4105C5Q Transcriptional regulator DR996_23135 ENOG4105N0V mono-oxygenase ydhR DR996_23150 ENOG4105KJF protein tyrosine phosphatase DR996_23155 ENOG4105DAY polysaccharide export protein DR996_23170 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DR996_23175 ENOG4108NRW Phospholipase, patatin family DR996_23190 ENOG4105CVP deoxyribo-dipyrimidine photolyase DR996_23210 ENOG4105C72 UPF0176 protein DR996_23215 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DR996_23240 ENOG4105DZ1 carboxypeptidase DR996_23255 ENOG4108RCM Nitroreductase DR996_23265 ENOG4105EJC lysr family transcriptional regulator DR996_23270 ENOG4105VYA Uncharacterized conserved protein (DUF2132) DR996_23280 ENOG4105DP0 ferredoxin-NADP reductase DR996_23295 ENOG41068P6 UPF0319 protein DR996_23300 ENOG4105IPI Membrane DR996_23340 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) DR996_23345 ENOG4105DDW LysR family Transcriptional regulator DR996_23365 ENOG4105G2Y Transcriptional regulator DR996_23370 ENOG4105CNH Multidrug resistance protein MdtL DR996_23380 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DR996_23385 ENOG4105I4A GCN5-related N-acetyltransferase DR996_23395 ENOG4105E3W Two component transcriptional regulator (Winged helix family DR996_23400 ENOG4105EB3 Histidine kinase DR996_23415 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DR996_23420 ENOG4105F1A Pyruvate formate-lyase DR996_23435 ENOG41075H3 AraC family transcriptional regulator DR996_23440 ENOG4105E7U AraC family transcriptional regulator DR996_23445 ENOG4107U2T alpha beta DR996_23470 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DR996_23475 ENOG4105C4M (Ubiquinol oxidase) subunit I DR996_23490 ENOG4105E18 UPF0276 protein DR996_23510 ENOG4107TIF Phenazine biosynthesis protein, PhzF family DR996_23515 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase DR996_23530 ENOG4105C5H ABC transporter DR996_23535 ENOG4105VYA Uncharacterized conserved protein (DUF2132) DR996_23540 ENOG4105HEI LysR family (Transcriptional regulator DR996_23545 ENOG4105Q8W reductase DR996_23550 ENOG4105CHF Glutathione S-transferase DR996_23555 ENOG4105C5H ABC transporter DR996_23570 ENOG4105HEI LysR family (Transcriptional regulator DR996_23585 ENOG4105W1N transcriptional regulator DR996_23600 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DR996_23605 ENOG4105N14 lysine exporter protein LysE YggA DR996_23635 ENOG4105W1N transcriptional regulator DR996_23650 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DR996_23655 ENOG4105N14 lysine exporter protein LysE YggA DR996_23685 ENOG4105CGH 5'-nucleotidase DR996_23695 ENOG4105CWX Alpha-1,2-mannosidase DR996_23705 ENOG4105CWX Alpha-1,2-mannosidase DR996_23710 ENOG4105CWX Alpha-1,2-mannosidase DR996_23715 ENOG4105DM4 PTS System DR996_23725 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DR996_23730 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DR996_23735 ENOG4105N2W Transcriptional regulator DR996_23740 ENOG4107P2S Transcriptional regulator DR996_23745 ENOG4105CI1 PTS System DR996_23750 ENOG4105C87 Aminotransferase class I and II DR996_23755 ENOG4105EIP mannose-6-phosphate isomerase DR996_23775 ENOG4105CH6 catalase DR996_23785 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DR996_23790 ENOG4108RWI nicotinamidase DR996_23800 ENOG4107RH7 Nicotinate phosphoribosyltransferase DR996_23815 ENOG4105RA2 Membrane DR996_23840 ENOG4105ETT transcriptional Regulator, LysR family DR996_23845 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DR996_23860 ENOG4108IJ7 Glycine betaine DR996_23865 ENOG4108HQS Glycine betaine DR996_23875 ENOG4105VYW UPF0251 protein DR996_23900 ENOG4105BZU Histidine kinase DR996_23910 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DR996_23920 ENOG4107S8C mandelate racemase muconate lactonizing DR996_23935 ENOG4105FDP GntR family transcriptional regulator DR996_23940 ENOG4105C5Y PTS System DR996_23945 ENOG4108HKT sucrose-6-phosphate hydrolase DR996_23960 ENOG4108Z4X TRANSCRIPTIONal DR996_23990 ENOG4107RZC phospholipase d DR996_24000 ENOG4105BZS acriflavin resistance protein DR996_24010 ENOG4105BZS acriflavin resistance protein DR996_24135 ENOG4105CEY Amp-dependent synthetase and ligase DR996_24155 ENOG41086KC Transcriptional regulator DR996_24165 ENOG4105BZU Histidine kinase DR996_24180 ENOG4105D6U Sodium Glutamate Symporter DR996_24185 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) DR996_24190 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DR996_24200 ENOG4107V40 secretion protein, HlyD family DR996_24205 ENOG4105HEI LysR family (Transcriptional regulator DR996_24245 ENOG4105G2Y Transcriptional regulator DR996_24255 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DR996_24260 ENOG4108S01 response regulator DR996_24270 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DR996_24275 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DR996_24280 ENOG4105HDK L-asparaginase DR996_24295 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DR996_24320 ENOG4105DDW LysR family Transcriptional regulator DR996_24325 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme DR996_24340 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DR996_24350 ENOG4105F27 Major Facilitator DR996_24355 ENOG4105CHR reductase DR996_24380 ENOG4105ETT transcriptional Regulator, LysR family DR996_24410 ENOG4105F27 Major Facilitator DR996_24415 ENOG4105CHR reductase DR996_24440 ENOG4105ETT transcriptional Regulator, LysR family DR996_24450 ENOG4105C1J atp-dependent rna helicase DR996_24480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DR996_24485 ENOG410874W AraC family transcriptional regulator DR996_24490 ENOG4105EJC lysr family transcriptional regulator DR996_24500 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DR996_24515 ENOG4108P3C DR996_24540 ENOG4105CHR reductase DR996_24550 ENOG4105NAE bifunctional deaminase-reductase domain protein DR996_24560 ENOG4105CYM Glutathione S-transferase DR996_24565 ENOG4105JQN Transcriptional regulator DR996_24570 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DR996_24575 ENOG4105C94 Transporter DR996_24580 ENOG4105DZ1 carboxypeptidase DR996_24585 ENOG4105BZU Histidine kinase DR996_24595 ENOG4105DMQ Methyltransferase DR996_24625 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DR996_24640 ENOG4105VEQ Cold shock protein DR996_24655 ENOG4105VEQ Cold shock protein DR996_24660 ENOG4105EUB pirin domain protein DR996_24665 ENOG4108NRW Phospholipase, patatin family DR996_24675 ENOG4105CD3 dihydroorotase DR996_24685 ENOG4105CKI cobalamin synthesis protein DR996_24705 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DR996_24725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DR996_24730 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DR996_24750 ENOG4105E98 transcriptional regulator DeoR family DR996_24760 ENOG4108M6U Universal stress protein A DR996_24785 ENOG4105C5H ABC transporter DR996_24810 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation DR996_24820 ENOG4108HK0 -acetyltransferase DR996_24830 ENOG4105CA0 peroxidase DR996_24845 ENOG4105M6F mutator MutT protein DR996_24860 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DR996_24905 ENOG4108IJF Heavy metal efflux pump, CzcA DR996_24925 ENOG4108IEG Formate dehydrogenase Alpha subunit DR996_24940 ENOG4107QWP ABC-2 type transporter DR996_24945 ENOG4105CJ1 ABC, transporter DR996_24955 ENOG4105C8Q Methyl-accepting chemotaxis DR996_24980 ENOG4108IA2 Sodium pantothenate symporter DR996_24985 ENOG4107SS6 2-dehydro-3-deoxygluconokinase DR996_24990 ENOG4108UHU Aldolase DR996_25000 ENOG4105E2D ec 3.2.1.52 DR996_25010 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) DR996_25015 ENOG4105JAB phenazine biosynthesis protein, phzf family DR996_25020 ENOG4108V1U phospholipid-binding protein DR996_25035 ENOG4105D6J arsenicaL-resistance protein DR996_25050 ENOG4105KVH Transcriptional regulator DR996_25065 ENOG4105JQN Transcriptional regulator DR996_25070 ENOG4107RGM aldo keto reductase DR996_25080 ENOG4105EIP mannose-6-phosphate isomerase DR996_25085 ENOG4105C8I hydrolase, family 38 DR996_25090 ENOG4105DM4 PTS System DR996_25095 ENOG4105FDP GntR family transcriptional regulator DR996_25100 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia DR996_25105 ENOG4105CTS PTS system mannitol-specific DR996_25110 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein DR996_25120 ENOG4107Z1W Fructose transport system kinase DR996_25145 ENOG4105E0U tyrosine-specific transport protein DR996_25155 ENOG4105C8Q Methyl-accepting chemotaxis DR996_25160 ENOG4105DWD nucleoside recognition domain protein DR996_25185 ENOG4105DR5 peptidase DR996_25195 ENOG4105E0A ABC, transporter DR996_25205 ENOG4105HFT AraC family transcriptional regulator DR996_25210 ENOG4105E0K tonB-dependent siderophore receptor DR996_25220 ENOG4105S6R Iron-hydroxamate transporter permease subunit DR996_25225 ENOG4105CR8 Transcriptional regulator DR996_25230 ENOG4105E5M Multidrug resistance protein D DR996_25250 ENOG4108SXK Transporter Drug Metabolite Exporter family DR996_25265 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DR996_25285 ENOG4105CCF Lysine exporter protein (Lyse ygga) DR996_25310 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) DR996_25335 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) DR996_25340 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DR996_25345 ENOG4105UYK outer membrane protein a DR996_25350 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DR996_25355 ENOG4105DXI Major Facilitator superfamily DR996_25360 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor DR996_25370 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DR996_25390 ENOG4105BZU Histidine kinase DR996_25395 ENOG4105KHC sulfurtransferase DR996_25415 ENOG4105D06 uba thif-type nad fad binding protein DR996_25420 ENOG4105CVM Molybdenum cofactor synthesis domain protein DR996_25425 ENOG4105EUJ GTP cyclohydrolase i DR996_25435 ENOG4105C5A transporter DR996_25460 ENOG4107RGM aldo keto reductase DR996_25465 ENOG4108UNF response regulator DR996_25475 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DR996_25480 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DR996_25515 ENOG4105BZU Histidine kinase DR996_25525 ENOG4107RGH Aldehyde dehydrogenase DR996_25530 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DR996_25535 ENOG4105C26 Dehydrogenase DR996_25540 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) DR996_25550 ENOG4108HQS Glycine betaine DR996_25555 ENOG4108IJ7 Glycine betaine DR996_25560 ENOG4108RCM Nitroreductase DR996_25570 ENOG4108TVJ Nitroreductase DR996_25580 ENOG4105C1G acyl-Coa dehydrogenase DR996_25585 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) DR996_25600 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DR996_25610 ENOG4107QX8 SPFH domain, Band 7 family protein DR996_25645 ENOG4105BZU Histidine kinase DR996_25670 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DR996_25720 ENOG4106W5V Membrane DR996_25740 ENOG4105M6F mutator MutT protein DR996_25755 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DR996_25760 ENOG4108K0B C-di-gmp phosphodiesterase DR996_25765 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DR996_25770 ENOG4105C2J ABC transporter DR996_25775 ENOG4105CNN ABC, transporter DR996_25780 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DR996_25785 ENOG4108RVA ribokinase DR996_25790 ENOG4105ETE Transcriptional regulator (LacI family DR996_25800 ENOG4106Z1T Nicotinamide Mononucleotide Transporter DR996_25805 ENOG4108I5U Uridine phosphorylase DR996_25825 ENOG4105DHS permease protein DR996_25830 ENOG4105CM4 permease protein DR996_25835 ENOG4108IPW abc transporter atp-binding protein DR996_25840 ENOG4108Z6Z Transcriptional regulator DR996_25850 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DR996_25895 ENOG4106YXT transposase DR996_25900 ENOG4108WTW DNA transposition protein DR996_25955 ENOG41065S5 DR996_26020 ENOG4105EM2 membrane DR996_26025 ENOG41088T4 Helicase IV DR996_26030 ENOG4108Z5K methylglyoxal synthase DR996_26035 ENOG4108SV3 Tmao reductase system periplasmic protein tort DR996_26040 ENOG4105BZU Histidine kinase DR996_26060 ENOG410804D Sensor Signal Transduction Histidine Kinase DR996_26070 ENOG4105ENH Sulfatase DR996_26075 ENOG4105ENH Sulfatase DR996_26080 ENOG4105ENH Sulfatase DR996_26085 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) DR996_26090 ENOG4105DQS Transcriptional regulator DR996_26095 ENOG4105ENH Sulfatase DR996_26100 ENOG4105C4X radical SAM domain protein DR996_26105 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DR996_26140 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) DR996_26145 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DR996_26150 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) DR996_26155 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DR996_26160 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DR996_26165 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DR996_26170 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DR996_26175 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DR996_26180 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DR996_26185 ENOG41064T2 transcriptional regulator, lysR family DR996_26190 ENOG4107TE5 Lipid kinase DR996_26195 ENOG4108YDI single-species biofilm formation on inanimate substrate DR996_26215 ENOG4105C4X radical SAM domain protein DR996_26225 ENOG4105F2V VRR-NUC domain-containing protein DR996_26240 ENOG4105D0M Protease HtpX homolog DR996_26245 ENOG4108V0P LemA family DR996_26250 ENOG4105CEE C4-dicarboxylate transporter DR996_26270 ENOG4108MGY Histidine kinase DR996_26275 ENOG4107KBT 8-Amino-7-oxononanoate synthase DR996_26280 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DR996_26285 ENOG4105DR5 peptidase DR996_26305 ENOG4105C7H Helicase, RecD TraA family DR996_26310 ENOG4105EKQ RNA-directed DNA polymerase DR996_26325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_26330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DR996_26335 ENOG4108WC9 type VI secretion system effector, hcp1 family DR996_26340 ENOG4105CS6 Rhs element vgr protein DR996_26365 ENOG4105D9P serine threonine protein kinase DR996_26400 ENOG4105EW9 transcriptional regulator AsnC family DR996_26475 ENOG4105BZU Histidine kinase DR996_26480 ENOG4105BZU Histidine kinase DR996_26485 ENOG4105BZU Histidine kinase DR996_26490 ENOG4108WQH regulatoR DR996_26495 ENOG4105BZU Histidine kinase DR996_26505 ENOG4108WQH regulatoR DR996_26510 ENOG4108NVR Methyl-accepting chemotaxis DR996_26515 ENOG4108TVJ Nitroreductase DR996_26520 ENOG4107R88 Chemotaxis protein (CheV) DR996_26555 ENOG4106CKV Pap2 superfamily protein DR996_26570 ENOG4105KPY Small multidrug resistance protein DR996_26575 ENOG4108I0N Transporter, RarD family, DMT superfamily protein DR996_26595 ENOG4107RGH Aldehyde dehydrogenase DR996_26605 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation DR996_26610 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DR996_26635 ENOG4105EXC Acyl-transferase DR996_26645 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DR996_26650 ENOG4108UYE Lactoylglutathione lyase DR996_26690 ENOG4105D9P serine threonine protein kinase DR996_26710 ENOG4106VK6 Flagellar motor protein DR996_26725 ENOG4108ZF3 Phosphatase DR996_26770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DR996_26780 ENOG4105CS6 Rhs element vgr protein DR996_26810 ENOG4107RFY SbcCD D subunit DR996_26815 ENOG4105EYH Exonuclease DR996_26825 ENOG4105E03 chitinase DR996_26855 ENOG4105QNF Outer membrane lipoprotein DR996_26865 ENOG4105C2C drug resistance transporter, Bcr CflA DR996_26875 ENOG4105CSX c4-dicarboxylate anaerobic carrier DR996_26885 ENOG4105C5W Aldolase DR996_26895 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) DR996_26900 ENOG4105EV2 VWA domain protein interacting with AAA ATPase DR996_26915 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DR996_26920 ENOG4105CBN LysR family transcriptional regulator DR996_26925 ENOG4105CXG d-lactate dehydrogenase DR996_27000 ENOG4108KHX Diguanylate cyclase DR996_27010 ENOG4107QZF nitrite reductase NADPH large subunit DR996_27015 ENOG4105WZK nitrite reductase NADPH small subunit DR996_27020 ENOG4105TMB Formate nitrite transporter DR996_27025 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DR996_27040 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DR996_27055 ENOG4105VXR cytoplasmic protein DR996_27060 ENOG4107QI1 Mate efflux family protein DR996_27075 ENOG4105K63 Thioredoxin DR996_27080 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DR996_27110 ENOG4105EFX secretion protein, HlyD family DR996_27120 ENOG4105IPI Membrane DR996_27130 ENOG4105EIP mannose-6-phosphate isomerase DR996_27135 ENOG4105CXY transporter DR996_27140 ENOG4105BZU Histidine kinase DR996_27145 ENOG4108KX4 response regulator DR996_27150 ENOG4105CXY transporter DR996_27225 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DR996_27230 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) DR996_27235 ENOG4107QI1 Mate efflux family protein DR996_27240 ENOG4105ECQ AraC Family Transcriptional Regulator DR996_27245 ENOG4105CGF Aromatic amino acid aminotransferase DR996_27260 ENOG4105WXI Bacterial OB fold (BOF) protein DR996_27265 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DR996_27270 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DR996_27275 ENOG4105E0C molybdate abc transporter DR996_27280 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DR996_27300 ENOG4105BZU Histidine kinase DR996_27315 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DR996_27320 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DR996_27355 ENOG4108ZJT translation initiation factor, Sui1 DR996_27365 ENOG4105CPF Cell wall formation (By similarity) DR996_27375 ENOG4105CD5 CoA-binding domain protein DR996_27380 ENOG4105CWB LysR family transcriptional Regulator DR996_27395 ENOG4105CMR udp-glucose 4-epimerase DR996_27400 ENOG4105BZU Histidine kinase DR996_27405 ENOG4105E7W lamb ycsf family protein DR996_27410 ENOG4105P4J Allophanate hydrolase, subunit 1 DR996_27425 ENOG4105CV6 ABC transporter, permease DR996_27430 ENOG4108I0Y (ABC) transporter DR996_27440 ENOG4105RKW reductase (By DR996_27445 ENOG4105BZU Histidine kinase DR996_27455 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DR996_27490 ENOG4105KA0 thioesterase Superfamily protein DR996_27505 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation DR996_27510 ENOG4108M0H Extracellular lipase DR996_27525 ENOG4105C3R Methionine synthase DR996_27540 ENOG4105DU1 integral membrane protein, terc DR996_27545 ENOG4105CGH 5'-nucleotidase DR996_27550 ENOG4105CPB ATP-dependent endonuclease of the OLD family DR996_27555 ENOG4108UQ5 membrane protein YcdZ DR996_27560 ENOG4105DUM transcriptional regulator, lysR family DR996_27570 ENOG4105TMB Formate nitrite transporter DR996_27575 ENOG4108YYC ycei family DR996_27580 ENOG4105DS1 cytochrome b561 DR996_27595 ENOG4108M8H domain protein DR996_27600 ENOG4105C1J atp-dependent rna helicase DR996_27605 ENOG4108ZYK Acyl carrier protein phosphodiesterase DR996_27615 ENOG4108N3W hemolysin secretion protein DR996_27625 ENOG4107YBY Hydrolase DR996_27630 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DR996_27645 ENOG4107RE1 Inosine-guanosine kinase DR996_27650 ENOG4105CKU formyltetrahydrofolate synthetase DR996_27655 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DR996_27665 ENOG4105CF7 AraC family transcriptional regulator DR996_27670 ENOG4108I6A alcohol dehydrogenase DR996_27680 ENOG4105CDA abc transporter atp-binding protein DR996_27685 ENOG4105E5Q amino acid AbC transporter DR996_27690 ENOG4106TNF Periplasmic binding protein DR996_27695 ENOG4105DRP amino acid AbC transporter DR996_27700 ENOG4108NJZ Sensory box GGDEF EAL domain protein DR996_27715 ENOG4107B7Y DNA-binding transcriptional regulator FruR DR996_27720 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein DR996_27725 ENOG4105DE4 1-phosphofructokinase DR996_27730 ENOG4105DM4 PTS System DR996_27775 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DR996_27785 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DR996_27790 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DR996_27795 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DR996_27800 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DR996_27855 ENOG4105CNH Multidrug resistance protein MdtL DR996_27895 ENOG4105BZ1 (ABC) transporter DR996_27970 ENOG4105FTV AraC Family Transcriptional Regulator DR996_27985 ENOG4105C94 Transporter DR996_28005 ENOG4105CKI cobalamin synthesis protein DR996_28040 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DR996_28050 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DR996_28075 ENOG4105IPI Membrane DR996_28110 ENOG4105DR5 peptidase DR996_28120 ENOG4105G2Y Transcriptional regulator DR996_28130 ENOG4105C4M (Ubiquinol oxidase) subunit I DR996_28135 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DR996_28140 ENOG4105KJM monovalent cation h antiporter subunit g DR996_28145 ENOG41080TA Multiple resistance and ph regulation protein f DR996_28150 ENOG4105SC1 monovalent cation H antiporter subunit E DR996_28155 ENOG4108JPZ Monovalent cation H antiporter subunit D DR996_28160 ENOG4108ZE9 Monovalent cation H antiporter subunit C DR996_28165 ENOG4105D65 subunit l DR996_28175 ENOG4105Q9Y Universal stress protein DR996_28185 ENOG4107HP6 Transcriptional regulator DR996_28190 ENOG4108RU0 short-chain dehydrogenase reductase DR996_28200 ENOG4105CIC tryptophan-specific transport protein DR996_28205 ENOG4108NIW Leucine export protein LeuE DR996_28220 ENOG4105GTN ParB Domain Protein Nuclease DR996_28230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DR996_28250 ENOG4106855 Competence protein DR996_28255 ENOG4105F3H Histidine kinase DR996_28260 ENOG4105ETX regulatoR DR996_28280 ENOG4105F3H Histidine kinase DR996_28285 ENOG4105ETX regulatoR DR996_28295 ENOG4105BZU Histidine kinase DR996_28305 ENOG4105F8J Adenylate Guanylate cyclase DR996_28335 ENOG4107QZF nitrite reductase NADPH large subunit DR996_28340 ENOG4105D7T ABC transporter DR996_28345 ENOG4105DG7 nitrate ABC transporter DR996_28375 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DR996_28390 ENOG4105BZU Histidine kinase DR996_28395 ENOG4105C44 Serine transporter DR996_28405 ENOG4105BZU Histidine kinase DR996_28430 ENOG4105G6Z alkaline phosphatase DR996_28445 ENOG4105ETX regulatoR DR996_28475 ENOG4106E5D Protein of unknown function (DUF461) DR996_28480 ENOG4105R8A Heat shock protein DR996_28495 ENOG4107RUY (E1 component), alpha subunit DR996_28500 ENOG4105CPP Dehydrogenase, E1 component DR996_28505 ENOG4107QSN dihydrolipoamide acetyltransferase DR996_28510 ENOG4105C10 Electron transfer flavoprotein DR996_28515 ENOG4105BZJ Electron transfer flavoprotein DR996_28525 ENOG4105EXG Transcriptional regulator DR996_28545 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) DR996_28550 ENOG4105ENH Sulfatase DR996_28560 ENOG41090KR LysR family transcriptional Regulator DR996_28570 ENOG4107RK6 Methyl-accepting chemotaxis DR996_28575 ENOG4105DMR ABC, transporter DR996_28660 ENOG4105C26 Dehydrogenase DR996_28675 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DR996_28680 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DR996_28685 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DR996_28690 ENOG4105CCU oxidase (Subunit III) DR996_28695 ENOG4105BZ9 Cytochrome C oxidase, subunit I DR996_28700 ENOG4105E2S oxidase) subunit II DR996_28710 ENOG4105CHR reductase DR996_28715 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DR996_28720 ENOG4105E39 Enoyl-CoA hydratase DR996_28725 ENOG4105E39 Enoyl-CoA hydratase DR996_28735 ENOG4105C26 Dehydrogenase DR996_28740 ENOG4105CHU acetyl-coa acetyltransferase DR996_28750 ENOG4105C1G acyl-Coa dehydrogenase DR996_28755 ENOG4107QX3 carboxylase DR996_28760 ENOG41060WC Enoyl-CoA hydratase DR996_28765 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DR996_28785 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i DR996_28805 ENOG4105EKQ RNA-directed DNA polymerase DR996_28810 ENOG4105D78 K07001 NTE family protein DR996_28815 ENOG4108YIV DR996_28820 ENOG4108F5E vimentin DR996_28830 ENOG4105EKQ RNA-directed DNA polymerase DR996_28850 ENOG4105CAF HipA N-terminal domain protein DR996_28860 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DR996_28890 ENOG4105DKW ABC transporter DR996_28895 ENOG4105BZU Histidine kinase DR996_28915 ENOG4105C1J atp-dependent rna helicase DR996_28920 ENOG4105BZU Histidine kinase DR996_28925 ENOG4105CKI cobalamin synthesis protein DR996_28935 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DR996_28955 ENOG4105VRT cytoplasmic protein DR996_28985 ENOG41090A4 Pterin carbinolamine dehydratase DR996_28990 ENOG4105MIR Phenylalanine 4-monooxygenase DR996_29000 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DR996_29005 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DR996_29025 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain DR996_29050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DR996_29060 ENOG4108RMU ferritin dps family protein DR996_29065 ENOG4105C8Q Methyl-accepting chemotaxis DR996_29090 ENOG4108MGY Histidine kinase DR996_29095 ENOG4105DFG type I secretion outer membrane protein DR996_29115 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DR996_29125 ENOG4107R39 (ABC) transporter DR996_29130 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DR996_29145 ENOG4105BZU Histidine kinase DR996_29160 ENOG4105VEQ Cold shock protein DR996_29180 ENOG4105CDV Ompa motb domain protein DR996_29190 ENOG4108V1T peptidylprolyl cis-trans isomerase DR996_29195 ENOG4107VXZ Hydrolase DR996_29200 ENOG4108YZN class I peptide chain release factor DR996_29205 ENOG4108N3W hemolysin secretion protein DR996_29220 ENOG4107YWA deoxycytidylate deaminase DR996_29225 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DR996_29240 ENOG4105WH1 Two component transcriptional regulator luxr family DR996_29245 ENOG4105BZU Histidine kinase DR996_29260 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DR996_29310 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class DR996_29320 ENOG4105CHU acetyl-coa acetyltransferase DR996_29340 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DR996_29345 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DR996_29375 ENOG4105EW9 transcriptional regulator AsnC family DR996_29390 ENOG4105BZU Histidine kinase DR996_29395 ENOG4108QGH periplasmic DR996_29400 ENOG41082IR Excinuclease ABC C subunit domain protein DR996_29405 ENOG4108YXG UPF0502 protein DR996_29415 ENOG41090HJ UPF0265 protein DR996_29425 ENOG4105EE0 oxidoreductase DR996_29430 ENOG4105BZU Histidine kinase DR996_29455 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DR996_29465 ENOG4105EW9 transcriptional regulator AsnC family DR996_29470 ENOG4105DVH amino acid DR996_29500 ENOG4105E0F Histidine kinase DR996_29505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DR996_29530 ENOG4105EFX secretion protein, HlyD family DR996_29535 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DR996_29540 ENOG4105CJW magnesium transporter DR996_29545 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin DR996_29550 ENOG4105DZC cytosine deaminase DR996_29565 ENOG4105EST Metal Dependent Phosphohydrolase DR996_29590 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DR996_29610 ENOG4108Z33 Thiol disulfide Interchange Protein DR996_29625 ENOG4105EMU Dehydrogenase DR996_29635 ENOG4107EXC regulatoR DR996_29640 ENOG4105JJR Histidine kinase DR996_29650 ENOG41080IJ Diacylglycerol kinase DR996_29655 ENOG4105DIJ Phosphoethanolamine transferase DR996_29665 ENOG4105EP9 oxidoreductase DR996_29670 ENOG41063TF transcriptional regulator (AraC DR996_29675 ENOG4108W2Y isochorismatase DR996_29700 ENOG41080IJ Diacylglycerol kinase DR996_29705 ENOG4105DIJ Phosphoethanolamine transferase DR996_29715 ENOG4105EP9 oxidoreductase DR996_29720 ENOG41063TF transcriptional regulator (AraC DR996_29725 ENOG4108W2Y isochorismatase DR996_29760 ENOG4105G2Y Transcriptional regulator DR996_29765 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DR996_29780 ENOG4105EJC lysr family transcriptional regulator DR996_29855 ENOG4105G2Y Transcriptional regulator DR996_29860 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DR996_29875 ENOG4105EJC lysr family transcriptional regulator DR996_29905 ENOG4105JQN Transcriptional regulator DR996_29940 ENOG4105KQ5 peptidylprolyl cis-trans isomerase DR996_29960 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related DR996_29965 ENOG41090JE Utilization Protein DR996_29970 ENOG4105D4P Coproporphyrinogen iii oxidase DR996_29975 ENOG4105WQ5 TonB family DR996_29980 ENOG41090AP transport protein DR996_29985 ENOG4106GFD transport protein DR996_29995 ENOG4105EHG Permease protein DR996_30000 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) DR996_30040 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DR996_30045 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DR996_30050 ENOG4105QVC MOSC domain-containing protein DR996_30050 ENOG4105QVC MOSC domain-containing protein DR996_30060 ENOG4105EKE dihydroorotase DR996_30065 ENOG4105CKW Inner membrane protein yedI DR996_30095 ENOG4105EG2 ABC transporter, permease DR996_30100 ENOG4105D56 permease protein DR996_30105 ENOG4107FKK extracellular solute-binding protein family 1 DR996_30115 ENOG4108IJ9 (ABC) transporter DR996_30140 ENOG4105D75 Capsular exopolysaccharide family DR996_30185 ENOG4105V0I UPF0267 protein DR996_30190 ENOG4108WUH Transcriptional regulator, TetR family DR996_30195 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DR996_30205 ENOG4105CH6 catalase DR996_30210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DR996_30230 ENOG4108YRF PTS System DR996_30240 ENOG4106R3P AraC family transcriptional regulator DR996_30245 ENOG4105DM4 PTS System DR996_30250 ENOG4105EIP mannose-6-phosphate isomerase DR996_30260 ENOG4105G2Y Transcriptional regulator DR996_30265 ENOG4105EFX secretion protein, HlyD family DR996_30270 ENOG4105KK7 inner membrane protein YiaW DR996_30300 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DR996_30310 ENOG4105CK2 sodium dicarboxylate symporter DR996_30315 ENOG4105CEP NADH dehydrogenase DR996_30330 ENOG4105CK1 PTS System DR996_30335 ENOG4105BZU Histidine kinase DR996_30345 ENOG4105KCK Peptidoglycan-associated lipoprotein DR996_30385 ENOG4105UYK outer membrane protein a DR996_30400 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DR996_30405 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DR996_30410 ENOG4105E2Z phosphate ABC transporter (Permease DR996_30415 ENOG4105C8U phosphate abc transporter DR996_30420 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) DR996_30430 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_30435 ENOG4108UW5 maltose o-acetyltransferase DR996_30445 ENOG4108JJ6 Type I secretion system ATPase DR996_30465 ENOG41086KC Transcriptional regulator DR996_30470 ENOG41086KC Transcriptional regulator DR996_30480 ENOG41069D7 Methyl-accepting chemotaxis DR996_30500 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DR996_30535 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DR996_30540 ENOG4105E2Z phosphate ABC transporter (Permease DR996_30545 ENOG4105C8U phosphate abc transporter DR996_30555 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DR996_30575 ENOG4107ENK receptor DR996_30580 ENOG4105CUG Oligopeptidase b DR996_30585 ENOG4105C1J atp-dependent rna helicase DR996_30595 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DR996_30600 ENOG4105CVP deoxyribo-dipyrimidine photolyase DR996_30605 ENOG4108XDN Transcriptional regulator DR996_30610 ENOG4107SEY Conserved Protein DR996_30620 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DR996_30635 ENOG4106TD9 Diguanylate cyclase DR996_30645 ENOG4105KK7 inner membrane protein YiaW DR996_30650 ENOG4105EFX secretion protein, HlyD family DR996_30655 ENOG4108V7D UPF0397 protein DR996_30660 ENOG4108JJB ABC transporter DR996_30675 ENOG4105XEP YhcH YjgK YiaL family protein DR996_30680 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DR996_30685 ENOG4105KBH arsR family transcriptional regulator DR996_30700 ENOG4105GXZ Ferredoxin-type protein NapH DR996_30705 ENOG4108BGM Quinol dehydrogenase periplasmic component DR996_30710 ENOG4108MK9 spermidine N(1)-acetyltransferase DR996_30725 ENOG4105YE1 PilZ domain DR996_30730 ENOG4107QE9 Inherit from COG: Membrane DR996_30740 ENOG4105DAN ATP-dependent protease DR996_30750 ENOG4108JQ5 ABC transporter DR996_30760 ENOG4105CC0 LysR family Transcriptional regulator DR996_30765 ENOG4105DAA L-lactate DR996_30770 ENOG4105DMF Dehydrogenase DR996_30785 ENOG4105D64 Mechanosensitive ion channel DR996_30805 ENOG4105CPQ Dehydrogenase DR996_30850 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DR996_30870 ENOG4105EXG Transcriptional regulator DR996_30875 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DR996_30895 ENOG4107SSZ Phosphatase DR996_30930 ENOG4105CW0 outer membrane usher protein DR996_30960 ENOG4105BZU Histidine kinase DR996_30970 ENOG4108JIR Flagellum-specific ATP synthase DR996_30980 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DR996_30985 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DR996_31010 ENOG4105DD5 Flagellar motor switch protein DR996_31015 ENOG4105CN7 Flagellar biosynthetic protein FliP DR996_31020 ENOG4105VS8 Flagellar biosynthetic protein fliq DR996_31025 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DR996_31030 ENOG4105D00 flagellar biosynthetic protein flhB DR996_31045 ENOG4105I03 Flagellin DR996_31055 ENOG410804A Flagellar hook-associated 2 domain-containing protein DR996_31060 ENOG4105MQ3 flagellar protein FliS DR996_31105 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DR996_31120 ENOG4108M3R transcriptional activator CadC DR996_31125 ENOG4105EE5 Membrane protein terC DR996_31145 ENOG4105HEI LysR family (Transcriptional regulator DR996_31150 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DR996_31170 ENOG4105DTJ flagellar hook-associated protein DR996_31175 ENOG4105E1Q flagellar hook-associated protein DR996_31180 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DR996_31185 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DR996_31190 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DR996_31195 ENOG4105CGA flagellar basal-body rod protein FlgG DR996_31200 ENOG4108KPB Flagellar basal-body rod protein FlgF DR996_31205 ENOG4105BZE flagellar hook protein, FlgE DR996_31210 ENOG4105W00 Flagellar hook capping protein DR996_31215 ENOG4108ZC9 flagellar basal-body rod protein flgc DR996_31220 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DR996_31240 ENOG4105E9H Lytic Murein transglycosylase DR996_31265 ENOG4105EJQ L-serine dehydratase DR996_31270 ENOG4105DUX Transporter DR996_31275 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DR996_31295 ENOG4105ETT transcriptional Regulator, LysR family DR996_31310 ENOG4105CJP fad dependent oxidoreductase DR996_31325 ENOG4108MJ5 VirK protein DR996_31365 ENOG4107STF Involved in phosphonate degradation (By similarity) DR996_31370 ENOG4108JPW Aminotransferase DR996_31375 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DR996_31380 ENOG4105ETE Transcriptional regulator (LacI family DR996_31410 ENOG4105KUU lipolytic protein G-D-S-L family DR996_31415 ENOG4105NYY transcriptional regulator, RpiR DR996_31420 ENOG4108HKT sucrose-6-phosphate hydrolase DR996_31430 ENOG4108YZG isomerase DR996_31435 ENOG4105DJV ribulose-phosphate 3-epimerase DR996_31440 ENOG4105EGS Mechanosensitive ion channel DR996_31475 ENOG4105PAD Hydrolase DR996_31480 ENOG4105JQN Transcriptional regulator DR996_31490 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DR996_31505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DR996_31520 ENOG4106TD9 Diguanylate cyclase DR996_31535 ENOG4105BZU Histidine kinase DR996_31555 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DR996_31560 ENOG4105D9N nucleoside DR996_31580 ENOG4105C0F tryptophanase EC 4.1.99.1 DR996_31585 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) DR996_31595 ENOG4105D5U fad dependent oxidoreductase DR996_31615 ENOG4105CWM branched-chain amino acid transport system II carrier protein DR996_31620 ENOG4105BZU Histidine kinase DR996_31625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DR996_31630 ENOG4105CQZ Histidine kinase DR996_31660 ENOG4108WAV Transcriptional regulator DR996_31685 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DR996_31690 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) DR996_31700 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) DR996_31705 ENOG4105CYW agmatinase DR996_31710 ENOG4105E5M Multidrug resistance protein D DR996_31715 ENOG4105CUG Oligopeptidase b DR996_31730 ENOG4105CC5 ABC transporter DR996_31735 ENOG4105DIK (ABC) transporter DR996_31740 ENOG4105DSE periplasmic solute binding protein DR996_31785 ENOG4109015 Biopolymer transport protein exbD tolR DR996_31810 ENOG410804D Sensor Signal Transduction Histidine Kinase DR996_31815 ENOG4105E3W Two component transcriptional regulator (Winged helix family DR996_31825 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DR996_31835 ENOG4105C5I Dehydrogenase DR996_31840 ENOG4108YYI Protein of unknown function (DUF2810) DR996_31895 ENOG4108TEM pseudouridine methyltransferase DR996_31910 ENOG4105DWF phosphomethylpyrimidine kinase DR996_31915 ENOG4108YI8 ABC transporter DR996_31920 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component DR996_31925 ENOG4107Z6I Thiamine biosynthesis protein DR996_31930 ENOG4105ETU transcriptional activator (TenA DR996_31935 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DR996_31940 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DR996_31945 ENOG4108WIQ phosphoesterase PA-phosphatase related protein DR996_31955 ENOG4105GR3 Histidine kinase DR996_31960 ENOG4107QY8 reductase DR996_31965 ENOG4105CUW cytochrome C-TYPE protein DR996_31975 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DR996_31995 ENOG4108W0I acetyltransferase DR996_32040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DR996_32045 ENOG4105BZW Glycerate kinase DR996_32050 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR DR996_32060 ENOG4105CI2 imidazolone-5-propionate hydrolase DR996_32085 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DR996_32095 ENOG4105D9N nucleoside DR996_32105 ENOG4105G2Y Transcriptional regulator DR996_32145 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase DR996_32160 ENOG4107WCA isomerase DR996_32180 ENOG4105C0R drug resistance transporter emrb qaca subfamily DR996_32195 ENOG4105H1G trap transporter solute receptor taxi family DR996_32200 ENOG4105EIF outer membrane protein W DR996_32205 ENOG4107W31 Pentapeptide repeat protein DR996_32220 ENOG410814C multidrug resistance protein DR996_32230 ENOG4108M1A Chitin-binding protein DR996_32235 ENOG4105EW9 transcriptional regulator AsnC family DR996_32250 ENOG4105Q26 Siderophore-interacting protein DR996_32265 ENOG4105CC0 LysR family Transcriptional regulator DR996_32280 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DR996_32300 ENOG4105KAF membrAne DR996_32335 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation DR996_32350 ENOG41066DY Membrane DR996_32355 ENOG41080ET plasmid maintenance system killer protein DR996_32360 ENOG4105VDM plasmid maintenance system antidote protein, xre family DR996_32620 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DR996_32690 ENOG4108YX2 DNA-binding protein DR996_32750 ENOG4105RWF major outer membrane protein OmpA DR996_32800 ENOG4108RS6 transposase DR996_32920 ENOG4105W5Q DNA repair protein (RadC DR996_32990 ENOG4105D13 transposase DR996_33045 ENOG4108YGG dna repair protein DR996_33120 ENOG4108ZHR arsR family transcriptional regulator DR996_33190 ENOG4106PHI plasmid recombination enzyme DR996_33225 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DR996_33330 ENOG4105DK2 UPF0207 protein DR996_33385 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DR996_33420 ENOG4105XPH Ferredoxin DR996_33480 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DR996_33530 ENOG4105C3F Signal peptidase i DR996_33545 ENOG4105T95 Thiol disulfide interChange protein DR996_33630 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DR996_33735 ENOG4107QJE Chromosome Partitioning Protein DR996_33785 ENOG4107W31 Pentapeptide repeat protein DR996_33860 ENOG4105CNA YD repeat protein DR996_34045 ENOG4105R8V Transcriptional regulator DR996_34095 ENOG4108IYH Dna topoisomerase DR996_34185 ENOG4107U4J modification DR996_34215 ENOG4107WZZ SMC domain protein DR996_34240 ENOG4107SKI cobyrinic Acid a,c-diamide synthase